Residual and recurrent gastrointestinal stromal tumors with KIT mutations: findings at first follow-up CT after imatinib treatment.
OBJECTIVE
The purpose of this study was to correlate findings on the first follow-up CT after treatment with imatinib in patients with residual or recurrent gastrointestinal stromal tumors (GISTs) with the different types of KIT mutation present at initial resection.


CONCLUSIONS
Residual and recurrent GISTs with KIT mutation of exon 11 deletion more frequently showed both tumor shrinkage and cystic change on 2-month follow-up CT images after the start of imatinib treatment than did other mutation types.
Choi
Dongil
D
Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50, Ilwon-Dong, Kangnam-Ku, Seoul 135-710, Korea. dichoi@skku.edu
Yoo
Eun Young
EY
Kim
Kyoung-Mee
KM
Sohn
Tae Sung
TS
Lee
Won Jae
WJ
Lee
Ji Young
JY
Chang
Ilsoo
I
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001549:Benzamides; D005260:Female; D005500:Follow-Up Studies; D046152:Gastrointestinal Stromal Tumors / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000235:genetics*; D006801:Humans; D000068877:Imatinib Mesylate; D008113:Liver Neoplasms / Q000556:secondary; D008175:Lung Neoplasms / Q000556:secondary; D008297:Male; D008875:Middle Aged; D009154:Mutation; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging*; D009366:Neoplasm Seeding; D018365:Neoplasm, Residual / Q000000981:diagnostic imaging*; D010446:Peptide Fragments / Q000627:therapeutic use; D010879:Piperazines / Q000627:therapeutic use; D019009:Proto-Oncogene Proteins c-kit / Q000235:genetics; D011743:Pyrimidines / Q000627:therapeutic use; D020796:Receptor, Platelet-Derived Growth Factor alpha / Q000235:genetics; D012189:Retrospective Studies; D013160:Splenic Neoplasms / Q000556:secondary; D014057:Tomography, X-Ray Computed
D001549:Benzamides; D010446:Peptide Fragments; D010879:Piperazines; D011743:Pyrimidines; C518603:protein kinase inhibitor peptide (5-24); D000068877:Imatinib Mesylate; D019009:Proto-Oncogene Proteins c-kit; D020796:Receptor, Platelet-Derived Growth Factor alpha