title: Total synthesis and bioactivity of resolvin E2.
abstract: Resolvin E2 is a potent anti-inflammatory compound, derived from eicosapentaenoic acid. The efficient total synthesis of resolvin E2 by taking advantage of its intrinsic pseudoenantiomeric substructures is reported. The synthetic resolvin E2 proved to be biologically active in blocking neutrophil infiltration and reducing proinflammatory cytokines in the acute peritonitis model.
authors.affiliation: Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
authors.forename: Seiji
authors.initials: S
authors.lastname: Ogawa
authors.forename: Daisuke
authors.initials: D
authors.lastname: Urabe
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Yokokura
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Arai
authors.forename: Makoto
authors.initials: M
authors.lastname: Arita
authors.forename: Masayuki
authors.initials: M
authors.lastname: Inoue
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D016207:Cytokines / Q000378:metabolism; D004195:Disease Models, Animal; D015118:Eicosapentaenoic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D051379:Mice; D020556:Neutrophil Infiltration / Q000187:drug effects; D010538:Peritonitis / Q000139:chemically induced; D013237:Stereoisomerism; D015054:Zymosan / Q000494:pharmacology
chemical_list: D000893:Anti-Inflammatory Agents; D016207:Cytokines; C517406:resolvin E2; D015054:Zymosan; D015118:Eicosapentaenoic Acid