[In vivo effect of food on absorption of fluoroquinolones].
Although food-drug interactions have been studied extensively in recent years, in the light of the complex nature of these interactions general guideline for clinical practice can not be given. Drug interactions with food (containing multivalent metal ions or protein) can have an influence on drug absorption with widely variety of mechanism, resulting in changes in both the rate and extent of bioavailability. Food-drug interaction can be important in the clinical practice. Studies of the interaction between food/juice and fluoroquinolones have produced conflicting results. A number of studies give evidence that fluoroquinolones forming slightly soluble complex with metal ions of food show reduced bioavailability. In the same time, concurrent ingestion of food/ juice with fluoroquinolones has been shown not to interfere with their absorption to a clinically significant degree.
Füredi
Petra
P
Semmelweis Egyetem Gyógyszerészeti Intézet, Budapest.
Pápai
Katalin
K
Budai
Marianna
M
Ludányi
Krisztina
K
Antal
István
I
Klebovich
Imre
I
D000818:Animals; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics; D001628:Beverages; D001682:Biological Availability; D024841:Fluoroquinolones / Q000493:pharmacokinetics*; D018565:Food-Drug Interactions / Q000502:physiology*; D006801:Humans; D007408:Intestinal Absorption / Q000502:physiology*; D007700:Kinetics; D008892:Milk
D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones