title: Design, synthesis, enzyme inhibition, and tumor cell growth inhibition of 2-anilinobenzamide derivatives as SIRT1 inhibitors.
abstract: A series of 2-anilinobenzamide derivatives were designed, synthesized and evaluated for their SIRT1-inhibitory activity. Among these, compounds 3 and 5 inhibited SIRT1 activity in enzyme assays and suppressed the growth of Daudi and HCT116 cells.
authors.affiliation: Nagoya City University, Tanabe-dori, Mizuho-ku, Aichi, Japan. suzuki@phar.nagoya-cu.ac.jp
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Suzuki
authors.forename: Keiko
authors.initials: K
authors.lastname: Imai
authors.forename: Erika
authors.initials: E
authors.lastname: Imai
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Iida
authors.forename: Ryuzo
authors.initials: R
authors.lastname: Ueda
authors.forename: Hiroki
authors.initials: H
authors.lastname: Tsumoto
authors.forename: Hidehiko
authors.initials: H
authors.lastname: Nakagawa
authors.forename: Naoki
authors.initials: N
authors.lastname: Miyata
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001549:Benzamides / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D001713:Biphenyl Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D003198:Computer Simulation; D015195:Drug Design; D006131:Growth Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D045325:HCT116 Cells; D006801:Humans; D017434:Protein Structure, Tertiary; D056564:Sirtuin 1; D037761:Sirtuins / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: C544480:2-(3-phenoxyphenylamino)benzamide; C544481:2-(biphenyl-3-ylamino)benzamide; D000970:Antineoplastic Agents; D001549:Benzamides; D001713:Biphenyl Compounds; D006131:Growth Inhibitors; C037689:benzamide; C447939:SIRT1 protein, human; D056564:Sirtuin 1; D037761:Sirtuins