title: Detection of the potential adulterant Teucrium chamaedrys in Scutellaria baicalensis raw material and extract by high-performance thin-layer chromatography.
abstract: Teucrium chamaedrys (Gemander) has been reported as an adulterant of Scutellaria lateriflora (American skullcap) herbal preparations and is also known to be hepatotoxic. A quick and simple high-performance thin-layer chromatographic (HPTLC) method was developed for the detection of T. chamaedrys (Germander) in S. baicalensis (Chinese skullcap) extract, an ingredient of the proprietary blend product, Univestin. The HPTLC profile of T. chamaedrys was distinguished from that of S. baicalensis by its bright green fluorescence bands. This simple method can be completed in an hour for the quality control of Univestin and its raw material, S. baicalensis. The method is sensitive and can detect T. chamaedrys at levels as low as 0.5% (w/w).
authors.affiliation: Unigen Inc., Quality Control/Quality Assurance Department, 2660 Willamette Dr, NE, Lacey, WA 98516, USA.
authors.forename: Thao
authors.initials: T
authors.lastname: Hong
authors.forename: Mijeong Lee
authors.initials: ML
authors.lastname: Jeong
authors.forename: Michael
authors.initials: M
authors.lastname: Zahn
authors.forename: Brooke A
authors.initials: BA
authors.lastname: Fay
authors.forename: Kangwoo
authors.initials: K
authors.lastname: Lee
authors.forename: Huunjung
authors.initials: H
authors.lastname: Hwangbo
authors.forename: Eunhye
authors.initials: E
authors.lastname: Park
authors.forename: Minjung
authors.initials: M
authors.lastname: Kim
authors.forename: Wenwen
authors.initials: W
authors.lastname: Ma
mesh_terms: D002855:Chromatography, Thin Layer / Q000379:methods*; D004340:Drug Contamination; D010936:Plant Extracts / Q000032:analysis*; D031364:Scutellaria baicalensis / Q000737:chemistry*; D012680:Sensitivity and Specificity; D031367:Teucrium / Q000737:chemistry*
chemical_list: D010936:Plant Extracts; C499814:Scutellaria baicalensis extract