title: Clevudine myopathy in patients with chronic hepatitis B.
abstract: Clevudine (L-FMAU) is a thymidine l-nucleoside analogue that was recently introduced for the treatment of chronic hepatitis B virus infection. Previous studies showed that clevudine has potent and sustained antiviral activity without causing viral resistance. No severe adverse event occurred during clinical trials. We describe two cases of drug-induced myopathy during long-term treatment of chronic hepatitis B with clevudine.
authors.affiliation: Department of Internal Medicine, Konkuk University School of Medicine, 4-12 Hwayang-dong, Gwangjin-gu, Seoul 143-729, Republic of Korea.
authors.forename: Byung Kook
authors.initials: BK
authors.lastname: Kim
authors.forename: Jeeyoung
authors.initials: J
authors.lastname: Oh
authors.forename: So Young
authors.initials: SY
authors.lastname: Kwon
authors.forename: Won Hyeok
authors.initials: WH
authors.lastname: Choe
authors.forename: Soon Young
authors.initials: SY
authors.lastname: Ko
authors.forename: Kyoung Hoon
authors.initials: KH
authors.lastname: Rhee
authors.forename: Tae Ho
authors.initials: TH
authors.lastname: Seo
authors.forename: So Dug
authors.initials: SD
authors.lastname: Lim
authors.forename: Chang Hong
authors.initials: CH
authors.lastname: Lee
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000009:adverse effects*; D001086:Arabinofuranosyluracil / Q000009:adverse effects / Q000031:analogs & derivatives*; D003402:Creatine Kinase / Q000097:blood; D004279:DNA, Viral / Q000097:blood; D004576:Electromyography; D005260:Female; D006515:Hepatitis B virus / Q000302:isolation & purification; D019694:Hepatitis B, Chronic / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D008875:Middle Aged; D009135:Muscular Diseases / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology
chemical_list: D000998:Antiviral Agents; D004279:DNA, Viral; D001086:Arabinofuranosyluracil; D003402:Creatine Kinase; C034935:clevudine