title: [Evaluation of nasal absorption for geniposide solution].
abstract: OBJECTIVE
  To investigate the regulation of geniposide nasal absorption.
  
  
  METHODS
  We used rat in situ nasal recirculation method as experimental model. The effects of perfusion volume, flow rate, perfusion concentration on nasal absorption of geniposide were studied.
  
  
  RESULTS
  Geniposide was stable in rats nasal lavage solution. At the perfusion volume 5 mL and flow rate 2.5 mL x min(-1), the absorption rate of geniposide remains constant in a dose-independent manner.
  
  
  CONCLUSIONS
  The mechanism of geniposide nasal absorption is passive diffusion following first order kinetics and the absorption rate constant is 4.20 x 10(-3).
authors.affiliation: Key Laboratory of Modern Preparation of Traditional Chinese Medicine, Nanchang 330004, China.
authors.forename: Na
authors.initials: N
authors.lastname: Wan
authors.forename: Haiyan
authors.initials: H
authors.lastname: Zhang
authors.forename: Runchun
authors.initials: R
authors.lastname: Xu
authors.forename: Qin
authors.initials: Q
authors.lastname: Zheng
authors.forename: Ming
authors.initials: M
authors.lastname: Yang
mesh_terms: D000042:Absorption; D000281:Administration, Intranasal; D000818:Animals; D004058:Diffusion; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000378:metabolism; D039823:Iridoids / Q000008:administration & dosage* / Q000378:metabolism*; D007700:Kinetics; D016014:Linear Models; D008297:Male; D009297:Nasal Mucosa / Q000378:metabolism*; D010477:Perfusion; D051381:Rats; D012680:Sensitivity and Specificity; D012996:Solutions
chemical_list: D004365:Drugs, Chinese Herbal; D039823:Iridoids; D012996:Solutions; C007835:geniposide