title: Adult vaccination strategies for the control of pertussis in the United States: an economic evaluation including the dynamic population effects.
abstract: BACKGROUND
  Prior economic evaluations of adult and adolescent vaccination strategies against pertussis have reached disparate conclusions. Using static approaches only, previous studies failed to analytically include the indirect benefits derived from herd immunity as well as the impact of vaccination on the evolution of disease incidence over time.
  
  
  METHODS
  We assessed the impact of different pertussis vaccination strategies using a dynamic compartmental model able to consider pertussis transmission. We then combined the results with economic data to estimate the relative cost-effectiveness of pertussis immunization strategies for adolescents and adults in the US. The analysis compares combinations of programs targeting adolescents, parents of newborns (i.e. cocoon strategy), or adults of various ages.
  
  
  RESULTS
  In the absence of adolescent or adult vaccination, pertussis incidence among adults is predicted to more than double in 20 years. Implementing an adult program in addition to childhood and adolescent vaccination either based on 1) a cocoon strategy and a single booster dose or 2) a decennial routine vaccination would maintain a low level of pertussis incidence in the long run for all age groups (respectively 30 and 20 cases per 100,000 person years). These strategies would also result in significant reductions of pertussis costs (between -77% and -80% including additional vaccination costs). The cocoon strategy complemented by a single booster dose is the most cost-effective one, whereas the decennial adult vaccination is slightly more effective in the long run.
  
  
  CONCLUSIONS
  By providing a high level of disease control, the implementation of an adult vaccination program against pertussis appears to be highly cost-effective and often cost-saving.
authors.affiliation: Sanofi Pasteur, Lyon, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Coudeville
authors.forename: Annelies
authors.initials: A
authors.lastname: Van Rie
authors.forename: Denis
authors.initials: D
authors.lastname: Getsios
authors.forename: J Jaime
authors.initials: JJ
authors.lastname: Caro
authors.forename: Pascal
authors.initials: P
authors.lastname: Crépey
authors.forename: Van Hung
authors.initials: VH
authors.lastname: Nguyen
mesh_terms: D000328:Adult; D003365:Costs and Cost Analysis; D006801:Humans; D017589:Immunization Programs / Q000191:economics / Q000706:statistics & numerical data*; D008962:Models, Theoretical; D011157:Population Dynamics; D014481:United States / Q000453:epidemiology; D014917:Whooping Cough / Q000453:epidemiology / Q000517:prevention & control*