Staphylococcal enterocolitis: forgotten but not gone?
OBJECTIVE
Staphylococcus aureus may cause antibiotic-associated diarrhea and enterocolitis, with or without preceding antibiotic use, in immunocompromised adults or infants, or individuals with predisposing conditions, but there is little appreciation of this condition clinically. CLINICAL DISEASE: The main clinical feature that helps to differentiate staphylococcal enterocolitis (SEC) from Clostridium difficile-associated diarrhea is large-volume, cholera-like diarrhea in the former case. A predominance of gram-positive cocci in clusters on gram stain of stool or biopsy specimens and the isolation of S. aureus as the dominant or sole flora support the diagnosis.


METHODS
The pathogenesis of SEC requires the interaction of staphylococcal enterotoxins, which function as superantigens, with interstitial epithelial lymphocytes and intestinal epithelial cells (IECs).


RESULTS
Most SEC represents recent S. aureus acquisition, so that improved infection prevention practices can reduce disease recurrence. Management should include aggressive fluid management and repletion and oral vancomycin.
Lin
Zheng
Z
Division of Gastroenterology, Department of Medicine, St. Luke's-Roosevelt Hospital Center, New York, NY 10025, USA.
Kotler
Donald P
DP
Schlievert
Patrick M
PM
Sordillo
Emilia Mia
EM
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D003937:Diagnosis, Differential; D004760:Enterocolitis / Q000175:diagnosis* / Q000276:immunology / Q000382:microbiology* / Q000628:therapy*; D005440:Fluid Therapy; D006801:Humans; D013203:Staphylococcal Infections / Q000175:diagnosis* / Q000276:immunology / Q000628:therapy*; D014640:Vancomycin / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D014640:Vancomycin