title: Solvent-independent antioxidant activity from thermally generated carbon-centered radical antioxidants.
abstract: A new and unusual class of chain-breaking antioxidants has been discovered, where the actual antioxidant is, paradoxically, a carbon-centered radical. Properties of these molecules are currently being studied. The solvent dependence on antioxidant activity of the HP-136 dimer has been measured, in solvents of varying H-bond accepting ability, by the inhibited oxygen uptake (IOU) method. As anticipated, the HP-136 dimer was found to show much less solvent effect on antioxidant activity than a representative phenolic antioxidant.
authors.affiliation: Department of Chemistry, University of Ottawa, Ottawa, Ontario, K1N 6N5, Canada.
authors.forename: Vasilisa
authors.initials: V
authors.lastname: Filippenko
authors.forename: Mathieu
authors.initials: M
authors.lastname: Frenette
authors.forename: J C
authors.initials: JC
authors.lastname: Scaiano
mesh_terms: D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D007700:Kinetics; D007783:Lactones / Q000737:chemistry; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry* / Q000494:pharmacology; D012997:Solvents / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000975:Antioxidants; C516855:HP-136; D007783:Lactones; D010636:Phenols; D012997:Solvents