title: Backbone and side-chain assignment of the lipidated and non-lipidated forms of the meningococcal outer membrane protein LP2086.
abstract: LP2086 is a lipidated outer membrane protein from Neisseria meningitidis that elicits bactericidal antibodies and represents a promising vaccine candidate against meningococcal infections. Here we report the backbone and side-chain assignment for two forms of LP2086: non-lipidated in aqueous buffer and the lipidated protein in micellar solution.
authors.affiliation: Wyeth Research, Structural Biology and Computational Chemistry, 200 Cambridge Park Drive, 02140, Cambridge, MA, USA. masci002@umn.edu
authors.forename: A
authors.initials: A
authors.lastname: Mascioni
authors.forename: J
authors.initials: J
authors.lastname: Jacob
authors.forename: F
authors.initials: F
authors.lastname: Moy
authors.forename: D
authors.initials: D
authors.lastname: Dilts
authors.forename: P
authors.initials: P
authors.lastname: Fink
authors.forename: K
authors.initials: K
authors.lastname: Malakian
authors.forename: S
authors.initials: S
authors.lastname: Sigethy
authors.forename: Y
authors.initials: Y
authors.lastname: Wen
authors.forename: E
authors.initials: E
authors.lastname: Novikova
authors.forename: G W
authors.initials: GW
authors.lastname: Zlotnick
authors.forename: D H H
authors.initials: DH
authors.lastname: Tsao
mesh_terms: D000595:Amino Acid Sequence; D000942:Antigens, Bacterial / Q000737:chemistry*; D001426:Bacterial Proteins / Q000737:chemistry*; D002247:Carbon Isotopes / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008563:Membrane Lipids / Q000737:chemistry*; D008823:Micelles; D008969:Molecular Sequence Data; D009587:Nitrogen Isotopes / Q000737:chemistry; D017434:Protein Structure, Tertiary; D021122:Protein Subunits; D011522:Protons
chemical_list: D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D002247:Carbon Isotopes; D008563:Membrane Lipids; D008823:Micelles; D009587:Nitrogen Isotopes; D021122:Protein Subunits; D011522:Protons; C484699:factor H-binding protein, Neisseria meningitidis