[Myocardial infiltration and formation of multiple granulocytic sarcoma of acute myeloid leukemia after cord blood transplantation].
A 57-year-old woman was diagnosed with acute myeloid leukemia (AML, M5a) with MLL rearrangement in August 2006. Cord blood transplantation (CBT) conditioned with a reduced-intensity regimen was carried out during second complete remission in March 2007. Marrow study on day 28 confirmed complete chimera and disappearance of minimal residual disease by RT-PCR. She complained of left chest pain around day 120. CT scan on day 127 showed left pleural effusion, tumors of the upper mediastinum and spleen, and pericardial effusion. She suddenly died of cardiogenic shock on day 129. Postmortem examination revealed systemic granulocytic sarcomas and infiltration of leukemic cells into the right atrium and epicardium without recurrence of leukemia in blood and marrow.
Hagihara
Maki
M
Department of Hematology, Kanagawa Cancer Center.
Motohashi
Kenji
K
Ohshima
Rika
R
Ito
Satomi
S
Sakuma
Yuji
Y
Kameda
Yoichi
Y
Maruta
Atsuo
A
Ishigatsubo
Yoshiaki
Y
Kanamori
Heiwa
H
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D036101:Cord Blood Stem Cell Transplantation / Q000009:adverse effects*; D017809:Fatal Outcome; D005260:Female; D015321:Gene Rearrangement; D006325:Heart Atria; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics / Q000473:pathology* / Q000628:therapy*; D017254:Leukemic Infiltration / Q000209:etiology*; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology*; D016609:Neoplasms, Second Primary; D010496:Pericardium; D023981:Sarcoma, Myeloid / Q000209:etiology*