title: Red blood cell (RBC) membrane proteomics--Part II: Comparative proteomics and RBC patho-physiology.
abstract: Membrane proteomics offers unprecedented possibilities to compare protein expression in health and disease leading potentially to the identification of markers, of targets for therapeutics and to a better understanding of disease mechanisms. From transfusion medicine to infectious diseases, from cardiovascular affections to diabetes, comparative proteomics has made a contribution to the identification of proteins unique to RBCs of patients with specific illnesses shedding light on possible RBC markers for systemic diseases. In this review we will provide a short overview of some of the main achievements obtained by comparative proteomics in the field of RBC-related local and systemic diseases and suggest some additional areas of RBCs research to which comparative proteomics approaches could be fruitfully applied or extended in combination with biochemical techniques.
authors.affiliation: Biomedical Primate Research Centre, Lange Kleiweg 139, 2288 GJ Rijswijk, The Netherlands.
authors.forename: Erica M
authors.initials: EM
authors.lastname: Pasini
authors.forename: Hans U
authors.initials: HU
authors.lastname: Lutz
authors.forename: Matthias
authors.initials: M
authors.lastname: Mann
authors.forename: Alan W
authors.initials: AW
authors.lastname: Thomas
mesh_terms: D000740:Anemia / Q000473:pathology / Q000503:physiopathology; D000818:Animals; D001803:Blood Transfusion / Q000379:methods / Q000706:statistics & numerical data; D004194:Disease; D004910:Erythrocyte Membrane / Q000378:metabolism*; D004912:Erythrocytes / Q000378:metabolism* / Q000473:pathology* / Q000502:physiology; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D040901:Proteomics / Q000379:methods*; D014183:Transplantation, Heterologous / Q000379:methods