title: Signal recognition particle (SRP) positive myositis in a patient with cryptogenic organizing pneumonia (COP).
abstract: We report of a 46-year-old female patient with cryptogen organizing pneumonia preceding the rare SRP positive necrotising myositis without cardiac involvement and no sign of dysphagia. Myositis showed full regression without oral immune suppression but with extracorporeal treatment, performed as a combined therapy of plasmaexchange and immunoadsorption. After 33-month of treatment, anti-SRP antibodies were not detectable any more.
authors.affiliation: Department of Pneumonology, Medical University of Vienna, Wilhelminenspital, Vienna, Austria. felix.wantke@wienkav.at
authors.forename: Felix
authors.initials: F
authors.lastname: Wantke
authors.forename: Meinhard
authors.initials: M
authors.lastname: Kneussl
authors.forename: Marianne
authors.initials: M
authors.lastname: Hubner
authors.forename: Kurt
authors.initials: K
authors.lastname: Derfler
authors.forename: Thomas
authors.initials: T
authors.lastname: Brücke
authors.forename: Sabine
authors.initials: S
authors.lastname: Schmaldienst
mesh_terms: D000974:Antibodies, Antinuclear / Q000097:blood; D003131:Combined Modality Therapy; D018549:Cryptogenic Organizing Pneumonia / Q000150:complications / Q000473:pathology* / Q000628:therapy; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007163:Immunosorbent Techniques; D008875:Middle Aged; D009220:Myositis / Q000150:complications / Q000473:pathology* / Q000628:therapy; D010951:Plasma Exchange; D013902:Radiography, Thoracic; D012129:Respiratory Function Tests; D012131:Respiratory Insufficiency / Q000150:complications / Q000473:pathology / Q000628:therapy; D018271:Signal Recognition Particle / Q000276:immunology*; D014057:Tomography, X-Ray Computed
chemical_list: D000974:Antibodies, Antinuclear; D005938:Glucocorticoids; D018271:Signal Recognition Particle