Novel pleuromutilin derivatives with excellent antibacterial activity against Staphylococcus aureus.
Ten novel pleuromutilin derivatives with thioether moiety and heterocyclic carboxamide or chloroformate group in the side chain were synthesized and confirmed by (1)H NMR, IR and HRMS. The results of the antibacterial activity showed that the title compounds had excellent antibacterial activity against Staphylococcus aureus, among which the MIC of 5f reached 0.03125 microg/mL.
Xu
Peng
P
College of Chemistry, Sichuan University, Chengdu, China.
Zhang
Yuan-Yuan
YY
Sun
Yong-Xue
YX
Liu
Jian-Hua
JH
Yang
Bing
B
Wang
Yu-Zhong
YZ
Wang
Yu-Liang
YL
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D011083:Polycyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D011720:Pyrazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects*; D000097567:Pleuromutilins
D000900:Anti-Bacterial Agents; D004224:Diterpenes; D011083:Polycyclic Compounds; D011720:Pyrazoles; D000097567:Pleuromutilins; C544204:mutilin 14-O-(1-(1-methyl-4-nitro-3-propyl-1H-pyrazolecarboxamide)-2-methylpropane-2-yl)thioacetate