Aplastic anemia following varicella vaccine.
Varicella zoster vaccine is a safe vaccine that is rarely associated with life-threatening complications. We describe an immunocompetent child who developed transient severe aplastic anemia concomitant with a typical clinical and laboratory-proven chickenpox syndrome 3 weeks after immunization. A causative association between the vaccine and the hematologic disease is possible, and pediatricians should be aware of this severe although rare adverse event.
Angelini
Paola
P
Division of Haematology and Oncology, Hospital for Sick Children, Toronto, Canada. paola.angelini@sickkids.ca
Kavadas
Fotini
F
Sharma
Navneet
N
Richardson
Susan E
SE
Tipples
Graham
G
Roifman
Chaim
C
Dror
Yigal
Y
Nofech-Mozes
Yehuda
Y
D000741:Anemia, Aplastic / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D019433:Chickenpox Vaccine / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D014645:Herpesvirus 3, Human / Q000235:genetics / Q000276:immunology; D006801:Humans; D016130:Immunophenotyping; D007223:Infant; D016133:Polymerase Chain Reaction; D012698:Serologic Tests
D019433:Chickenpox Vaccine