Fatal cytotoxic cutaneous lymphoma presenting as ulcerative psoriasis.
BACKGROUND
Psoriasis is a common, nonulcerative skin disorder.


METHODS
We describe 3 men recently referred to our institution for evaluation and treatment of severe, ulcerative psoriasis that ultimately was determined to be aggressive, cytotoxic, cutaneous lymphoma. Each had a history of relatively indolent, nonulcerative patches and plaques (duration, 2-45 years) that changed to ulcerated lesions; these rapidly progressed and eventuated in death.


CONCLUSIONS
The clinical characteristics of the skin lesions and the histopathologic findings form a distinct and rare presentation of cutaneous lymphoma. The initial course is similar to that of mycosis fungoides but eventuates in a highly aggressive disease with fatal outcome.
Weenig
Roger H
RH
Department of Dermatology, Mayo Clinic, Rochester, MN 55905, USA. Weenig.Roger@mayo.edu
Comfere
Nneka I
NI
Gibson
Lawrence E
LE
Alonso-Llamazares
Javier
J
Davis
Mark D P
MD
Pittelkow
Mark R
MR
el-Azhary
Rokea A
RA
D000368:Aged; D017809:Fatal Outcome; D006801:Humans; D016410:Lymphoma, T-Cell, Cutaneous / Q000150:complications* / Q000175:diagnosis*; D008875:Middle Aged; D011565:Psoriasis / Q000209:etiology*; D012878:Skin Neoplasms / Q000150:complications* / Q000175:diagnosis*; D012883:Skin Ulcer / Q000209:etiology*