The effect of magnesium sulfate treatment on blood biochemistry and bleeding time in patients with severe preeclampsia.
OBJECTIVE
The objective of this study was to observe the effects of magnesium sulfate on various blood biochemical parameters and coagulation status of patients with preeclampsia.


METHODS
During a period of 4 years, 50 patients with severe or mild preeclampsia progressing to severe preeclampsia were included in the cross-sectional study. Prothrombine (PT), activated limited thromboplastin time (aPTT), magnesium level, biochemistry parameters, systolic, and diastolic blood pressure (BP) were measured. These parameters were remeasured in the second hour of magnesium sulfate treatment.


RESULTS
After magnesium sulfate therapy; creatinine levels are decreased (p < 0.05), bleeding time is increased and serum magnesium levels are increased (p < 0.01), systolic and diastolic BP values decreased significantly (p < 0.01). PT, aPTT, platelet levels, and coagulation time did not change after treatment.


CONCLUSIONS
Magnesium sulfate infusion prolonged bleeding time in patients with severe preeclampsia. This is clinically important because it worsens the present condition and causes possible complications.
Guzin
Kadir
K
SB Istanbul Goztepe Education and Research Hospital, Istanbul, Turkey.
Goynumer
Gokhan
G
Gokdagli
Fulya
F
Turkgeldi
Engin
E
Gunduz
Gunes
G
Kayabasoglu
Furkan
F
D000927:Anticonvulsants / Q000009:adverse effects / Q000627:therapeutic use; D001671:Biochemistry; D001724:Birth Weight / Q000187:drug effects; D001760:Bleeding Time; D001774:Blood Chemical Analysis; D001794:Blood Pressure / Q000187:drug effects; D003430:Cross-Sectional Studies; D005260:Female; D005343:Fibrinolytic Agents / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D007226:Infant Mortality; D007231:Infant, Newborn; D008278:Magnesium Sulfate / Q000009:adverse effects / Q000627:therapeutic use*; D011225:Pre-Eclampsia / Q000097:blood* / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D011247:Pregnancy; D047928:Premature Birth / Q000453:epidemiology; D012720:Severity of Illness Index
D000927:Anticonvulsants; D005343:Fibrinolytic Agents; D008278:Magnesium Sulfate