Relationship among dietary estimates of net endogenous acid production, bone mineral density and biochemical markers of bone turnover in an Iranian general population.
Chronic, low-grade metabolic acidosis due to Western diets may be a risk factor for osteoporosis. The severity can be determined in part by net endogenous acid production (NEAP). In a population-based study, a total of 1028 healthy men and women aged 20-72 years were evaluated for dietary intakes and NEAP estimates with a validated food frequency questionnaire. Dual-energy X-ray absorptiometry (DXA) was used to determine BMD of the lumbar spine (L2-L4), distal third of radius, and proximal femur. Serum CrossLaps, degradation products of the C-terminal telopeptides of type I collagen, and osteocalcin were measured by highly specific ELISA methods. Lower estimates of energy-adjusted rates of NEAP were associated with greater femoral neck BMD (p=0.01) in premenopausal women and with greater BMDs at the distal radius (p=0.001) and lumbar spine (p=0.04) in postmenopausal women. Compared with women in the highest quartile of the estimates of the energy-adjusted rates of NEAP, pre- and postmenopausal women in the lowest quartile had significantly greater means of osteocalcin [9.12 (SD+/-1.62) vs. 5.24 (SD+/-1.41) ng/ml, p=0.02 and 11.74 (SD+/-1.69) vs. 7.79 (SD+/-2.63) ng/ml, p=0.002, respectively]. Analysis by quartiles of the estimates of energy-adjusted rates of NEAP did not reveal a relationship between BMD and bone turnover markers in men. In conclusion, we found that a high energy-adjusted rate of NEAP was associated with a significantly lower BMD in women but not in men and the energy-adjusted rate of NEAP had a negative relationship with bone formation.
Rahbar
Alireza
A
Department of Nutrition, The Persian Gulf Tropical Medicine Research Center, Bushehr University of Medical Sciences, Bushehr, Islamic Republic of Iran. rahbar_alireza@yahoo.com
Larijani
Bagher
B
Nabipour
Iraj
I
Mohamadi
Mohamad Mehdi
MM
Mirzaee
Kamran
K
Amiri
Zahra
Z
D000143:Acids / Q000378:metabolism*; D000328:Adult; D000368:Aged; D044466:Asian People; D015415:Biomarkers / Q000378:metabolism; D015519:Bone Density / Q000502:physiology*; D016723:Bone Remodeling / Q000502:physiology*; D004032:Diet; D005260:Female; D005272:Femur Neck / Q000502:physiology; D006801:Humans; D007492:Iran; D008159:Lumbar Vertebrae / Q000502:physiology; D008297:Male; D008875:Middle Aged; D017698:Postmenopause / Q000502:physiology; D011188:Potassium / Q000378:metabolism; D017697:Premenopause / Q000502:physiology; D011884:Radius / Q000502:physiology; D055815:Young Adult
D000143:Acids; D015415:Biomarkers; D011188:Potassium