[Age-dependent changes of superoxide dismutase, glutathione peroxidase, and catalase activity in the brain of rats during immobilized stress].
This work was aimed at the study of activity of antioxidant enzymes (SOD, glutathione peroxidase and catalase) in mitochondrial and postmitochondrial fraction of brain homogenate of adult (10-12 month.) and old (22-25 month.) Wistar male rats during immobilized stress. Investigations have shown that immobilization of adult rats was accompanied by the appearance of characteristic changes in the activity of SOD and glutathione peroxidase from postmitochondrial fraction. These changes promote the oxidative stress in the brain. Immobilization of old rats was not accompanied by the change in SOD and glutathione peroxidase activity.
Suvorova
I N
IN
Davydov
V V
VV
D000375:Aging / Q000378:metabolism*; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001921:Brain / Q000201:enzymology*; D002374:Catalase / Q000378:metabolism*; D005979:Glutathione Peroxidase / Q000378:metabolism*; D008297:Male; D008928:Mitochondria / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000201:enzymology*; D013482:Superoxide Dismutase / Q000378:metabolism*
D000975:Antioxidants; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase