title: Size control of arsenic trioxide nanocrystals grown in nanowells.
abstract: This paper describes a new strategy to generate nanocrystalline drugs through the precipitation of drug molecules in attoliter nanowells. We controlled the size of arsenic trioxide (ATO) nanocrystals by simply changing the concentration of ATO solution in the nanowells; particles with sizes ranging from 55 to 175 nm were formed. This approach only requires the drugs to be soluble in a solvent and thus can be broadly applicable to produce other drugs in nanocrystalline form.
authors.affiliation: Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3133, USA.
authors.forename: Eun-Ah
authors.initials: EA
authors.lastname: You
authors.forename: Richard W
authors.initials: RW
authors.lastname: Ahn
authors.forename: Min Hyung
authors.initials: MH
authors.lastname: Lee
authors.forename: Meera R
authors.initials: MR
authors.lastname: Raja
authors.forename: Thomas V
authors.initials: TV
authors.lastname: O'Halloran
authors.forename: Teri W
authors.initials: TW
authors.lastname: Odom
mesh_terms: D000077237:Arsenic Trioxide; D001152:Arsenicals / Q000737:chemistry*; D003460:Crystallization / Q000379:methods; D053758:Nanoparticles; D010087:Oxides / Q000737:chemistry*; D010316:Particle Size; D004364:Pharmaceutical Preparations / Q000737:chemistry*
chemical_list: D001152:Arsenicals; D010087:Oxides; D004364:Pharmaceutical Preparations; D000077237:Arsenic Trioxide