eNOS G894T polymorphism and abdominal aortic aneurysms.
BACKGROUND
The genetic risk factors that contribute to the risk of developing abdominal aortic aneurysm (AAA) are poorly understood. We assessed the association of endothelial nitric oxide synthase (eNOS) gene polymorphism with AAA.


METHODS
eNOS gene polymorphism of 61 patients with AAA and 62 control participants were analyzed by polymerase chain reaction (PCR)-restriction technique.


RESULTS
eNOS G894 homozygote T/T genotype polymorphism and 894T allele frequency in patients with AAA were significantly higher than those of the control participants (P = .01, P = .03). Among patients with AAA, the eNOS G894 T/T polymorphism and 894T allele frequency were associated with larger AAAs.


CONCLUSIONS
The current study, in a small group of participants, showed a relationship between eNOS G894T polymorphism and AAA.
Atli
Fahri Hayri
FH
Department of Cardiovascular Surgery, Urfa State Hospital, Urfa, Turkey.
Manduz
Sinasi
S
Katrancioglu
Nurkay
N
Ozum
Unal
U
Disli
Olcay Murat
OM
Atahan
Erhan
E
Ozdemir
Ozturk
O
Dogan
Kasim
K
Berkan
Ocal
O
D000368:Aged; D017544:Aortic Aneurysm, Abdominal / Q000235:genetics* / Q000503:physiopathology; D004730:Endothelium, Vascular / Q000503:physiopathology; D005260:Female; D005787:Gene Frequency; D006801:Humans; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000502:physiology; D052250:Nitric Oxide Synthase Type III / Q000235:genetics*; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length
D009569:Nitric Oxide; D052250:Nitric Oxide Synthase Type III