Copper(II) complexes of coumarin-derived Schiff bases and their anti-Candida activity.
The condensation of 7-amino-4-methyl-coumarin (1) with a number of substituted salicylaldehydes yielded a series of Schiff bases (2a-2k) in good yields. Subsequent reaction of these ligands with copper(II) acetate yielded Cu(II) complexes (3a-3k) and some were characterised using X-ray crystallography. All of the free ligands and their metal complexes were tested for their anti-Candida activity. A number of the ligands and complexes exhibited anti-Candida activity comparable to that of the commercially available antifungal drugs, ketoconazole and Amphotericin B.
Creaven
Bernadette S
BS
Department of Science, Institute of Technology Tallaght, Dublin, Ireland. bernie.creaven@it-tallaght.ie
Devereux
Michael
M
Karcz
Dariusz
D
Kellett
Andrew
A
McCann
Malachy
M
Noble
Andy
A
Walsh
Maureen
M
D000447:Aldehydes / Q000737:chemistry*; D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects*; D002614:Chelating Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D003300:Copper / Q000737:chemistry*; D003374:Coumarins / Q000737:chemistry*; D018360:Crystallography, X-Ray; D015195:Drug Design; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D012545:Schiff Bases / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013053:Spectrophotometry; D044366:Transition Temperature
D000447:Aldehydes; D000935:Antifungal Agents; D002614:Chelating Agents; D003374:Coumarins; D008024:Ligands; D009942:Organometallic Compounds; D012545:Schiff Bases; D003300:Copper; C028743:7-amino-4-methylcoumarin