title: Pulmonary artery growth following arterial duct stenting in congenital heart disease with duct-dependent pulmonary circulation.
abstract: OBJECTIVE
  The aim of this study was to assess the pulmonary artery (PA) growth following arterial duct (AD) stenting in neonates with congenital heart disease (CHD) with duct-dependent pulmonary circulation.
  
  
  BACKGROUND
  AD stenting is increasingly deemed as a reliable alternative to surgical shunt in CHD with duct-dependent pulmonary circulation. Allowing the stent to conform to the PA anatomy might avoid any unbalance of lung perfusion and promote a uniform growth of the main PAs.
  
  
  METHODS
  Of the 47 neonates and infants submitted to AD stenting as palliation of CHD with duct-dependent pulmonary circulation at our Institution, 15 underwent angiographic evaluation of the PA development before surgical repair due to progressive decrease of the systemic oxygen saturation. The Nakata and McGoon indexes as well as the left-to-right PA diameter ratio were considered as being indicative of global and balanced growth.
  
  
  RESULTS
  Ductal stabilization was achieved with coronary stents dilated to 3.3 + or - 0.4 mm (range 2.5-4). The control angiography was performed 7 + or - 3 months (range 3-13) after the stenting procedure. At that time, the Nakata and McGoon indexes had significantly increased from 132 + or - 67 to 287 + or - 94 mm/m(2) and from 1.6 + or - 0.3 to 2.1 + or - 0.2 mm/m(2), respectively (P < 0.0001 for both comparisons), due to uniform vascular growth (left PA z-score from -0.7 + or - 1.6 to 1.4 + or - 1.2; right PA from -0.8 + or - 1.4 to 1.4 + or - 1.2, P < 0.0001 for both comparisons; final left-to-right PA ratio 0.9 + or - 0.1).
  
  
  CONCLUSIONS
  Percutaneous AD stabilization with highly flexible coronary stents is effective in promoting a significant and balanced growth of the PAs in CHD with duct-dependent pulmonary circulation.
authors.affiliation: Department of Pediatric Cardiology, "Monaldi" Hospital, 2nd University of Naples, Naples, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Santoro
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Palladino
authors.forename: Giovanbattista
authors.initials: G
authors.lastname: Capozzi
authors.forename: Carola
authors.initials: C
authors.lastname: Iacono
authors.forename: Maria Giovanna
authors.initials: MG
authors.lastname: Russo
authors.forename: Raffaele
authors.initials: R
authors.lastname: Calabrò
mesh_terms: D006328:Cardiac Catheterization / Q000295:instrumentation*; D002858:Chromium Alloys; D004374:Ductus Arteriosus, Patent / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy*; D006330:Heart Defects, Congenital / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D010166:Palliative Care; D011474:Prosthesis Design; D011651:Pulmonary Artery / Q000000981:diagnostic imaging / Q000254:growth & development* / Q000503:physiopathology; D011652:Pulmonary Circulation; D011859:Radiography; D015607:Stents; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D002858:Chromium Alloys