title: RepliVAX WN, a single-cycle flavivirus vaccine to prevent West Nile disease, elicits durable protective immunity in hamsters.
abstract: West Nile virus (WNV) causes significant disease, yet no vaccines exist to prevent WN disease in humans. We have previously reported that RepliVAX WN is a safe and efficacious vaccine in mouse and hamster models of WN disease. Here, we report that vaccination of hamsters with RepliVAX WN induces antibody responses that remain stable for at least 6 months. Furthermore, animals challenged with virulent WNV 6 months after vaccination were protected from disease as well as those challenged 2 months post-vaccination, with no vaccinated animals succumbing to WNV challenge. These results indicate that RepliVAX is capable of inducing durable protective immunity after a single dose.
authors.affiliation: Department of Microbiology and Immunology, University of Texas Medical Branch (UTMB), Galveston, TX 77555, United States.
authors.forename: Douglas G
authors.initials: DG
authors.lastname: Widman
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Ishikawa
authors.forename: Evandro R
authors.initials: ER
authors.lastname: Winkelmann
authors.forename: Ernesto
authors.initials: E
authors.lastname: Infante
authors.forename: Nigel
authors.initials: N
authors.lastname: Bourne
authors.forename: Peter W
authors.initials: PW
authors.lastname: Mason
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D006224:Cricetinae; D005416:Flavivirus / Q000235:genetics*; D005822:Genetic Vectors; D006801:Humans; D008647:Mesocricetus; D051379:Mice; D016019:Survival Analysis; D014765:Viral Vaccines / Q000235:genetics / Q000276:immunology*; D014901:West Nile Fever / Q000517:prevention & control*; D014902:West Nile virus / Q000235:genetics / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D014765:Viral Vaccines