title: Acute and chronic anti-inflammatory properties of the stem bark aqueous and methanol extracts of Sclerocarya birrea (Anacardiaceae).
abstract: Sclerocarya birrea is used in folk medicine for the treatment of inflammatory disorders. The effect of the stem bark aqueous and methanol extracts of S. birrea (150 or 300 mg/kg) was evaluated on carrageenan-, histamine- or serotonin-induced paw oedema in rats. The methanol extract of S. birrea (300 mg/kg) being the most active, exhibited a maximum inhibition of 75.45 and 55.31% on carrageenan- and histamine-induced inflammation, respectively. When administered at 300 mg/kg, the methanol extract of S. birrea also exhibited 80.68% inhibition on the 10th day and 54.43% inhibition on the 21st day in formalin- or complete Freund's adjuvant (CFA)-induced paw oedema in rats. GSH level was significantly increased (75.14%), while MAD level was significantly decreased (31.22%) in the liver of CFA rats treated with S. birrea (300 mg/kg). The results suggest that the anti-inflammatory activity of the aqueous and methanol extracts of S. birrea is due to the inhibition of histamine and prostaglandin pathways and to its antioxidant activity.
authors.affiliation: Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon.
authors.forename: Agathe L
authors.initials: AL
authors.lastname: Fotio
authors.forename: Théophile
authors.initials: T
authors.lastname: Dimo
authors.forename: Télesphore B
authors.initials: TB
authors.lastname: Nguelefack
authors.forename: Paul D D
authors.initials: PD
authors.lastname: Dzeufiet
authors.forename: Esther
authors.initials: E
authors.lastname: Ngo Lemba
authors.forename: Roméo J
authors.initials: RJ
authors.lastname: Temdie
authors.forename: Florence
authors.initials: F
authors.lastname: Ngueguim
authors.forename: Maria L
authors.initials: ML
authors.lastname: Olleros
authors.forename: Dominique
authors.initials: D
authors.lastname: Vesin
authors.forename: Etienne
authors.initials: E
authors.lastname: Dongo
authors.forename: Pierre
authors.initials: P
authors.lastname: Kamtchouing
authors.forename: Irene
authors.initials: I
authors.lastname: Garcia
mesh_terms: D027926:Anacardiaceae / Q000737:chemistry*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D000975:Antioxidants / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000188:drug therapy / Q000503:physiopathology; D005260:Female; D005978:Glutathione / Q000187:drug effects / Q000378:metabolism; D007249:Inflammation / Q000188:drug therapy* / Q000503:physiopathology; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008519:Medicine, Traditional; D024301:Plant Bark; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D018547:Plant Stems; D011453:Prostaglandins / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D010936:Plant Extracts; D011453:Prostaglandins; D008315:Malondialdehyde; D005978:Glutathione