title: Ipsilateral breast tumor relapse after breast conserving surgery in women with breast cancer.
abstract: Ipsilateral breast tumor relapse (IBTR) is a potentially a significant problem after breast conserving surgery (BCS). With a median follow-up period of 64.7 months, IBTR occurred as a first relapse in 67 (3.0%) of a total of 2243 patients and distant recurrence occurred in 167 (7.4%). A positive surgical margin and the omission of radiotherapy (RT) were independently associated with IBTR. The five-year cumulative IBTR rates were 5.1% in patients with positive margins and 2.0% in the patients with negative margins. The five-year cumulative IBTR rates were 1.8% in patients with RT and 8.1% in patients without RT. IBTR was independently associated with distant-recurrence-free survival rates as well as age, nodal metastasis, lymphovascular invasion and progesterone receptor status. The five-year distant-recurrence-free survival rates were 81.9% in patients with IBTR and 93.2% in patients without IBTR. In order to prevent IBTR, a negative margin and the administration of RT are therefore considered to be important in patients who undergo BCS.
authors.affiliation: Division of Breast Surgery, Saitama Cancer Center, 818 Komuro, Ina, Kita-Adachi, Saitama 362-0806, Japan. ytakashi@cancer-c.pref.saitama.jp
authors.forename: Takashi
authors.initials: T
authors.lastname: Yoshida
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Takei
authors.forename: Masafumi
authors.initials: M
authors.lastname: Kurosumi
authors.forename: Jun
authors.initials: J
authors.lastname: Ninomiya
authors.forename: Yuko
authors.initials: Y
authors.lastname: Ishikawa
authors.forename: Yuji
authors.initials: Y
authors.lastname: Hayashi
authors.forename: Katsunori
authors.initials: K
authors.lastname: Tozuka
authors.forename: Hanako
authors.initials: H
authors.lastname: Oba
authors.forename: Kenichi
authors.initials: K
authors.lastname: Inoue
authors.forename: Toshio
authors.initials: T
authors.lastname: Tabei
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D015412:Mastectomy, Segmental; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology*; D018714:Radiotherapy, Adjuvant; D012307:Risk Factors