Cognitive performance is related to cortical grey matter volumes in early stages of schizophrenia: a population-based study of first-episode psychosis.
BACKGROUND
Neuropsychological deficits have been reported in association with first-episode psychosis (FEP). Reductions in grey matter (GM) volumes have been documented in FEP subjects compared to healthy controls. However, the possible inter-relationship between the findings of those two lines of research has been scarcely investigated.


OBJECTIVE
To investigate the relationship between neuropsychological deficits and GM volume abnormalities in a population-based sample of FEP patients compared to healthy controls from the same geographical area.


METHODS
FEP patients (n=88) and control subjects (n=86) were evaluated by neuropsychological assessment (Controlled Oral Word Association Test, forward and backward digit span tests) and magnetic resonance imaging using voxel-based morphometry.


RESULTS
Single-group analyses showed that prefrontal and temporo-parietal GM volumes correlated significantly (p<0.05, corrected) with cognitive performance in FEP patients. A similar pattern of direct correlations between neocortical GM volumes and cognitive impairment was seen in the schizophrenia subgroup (n=48). In the control group, cognitive performance was directly correlated with GM volume in the right dorsal anterior cingulate cortex and inversely correlated with parahippocampal gyral volumes bilaterally. Interaction analyses with "group status" as a predictor variable showed significantly greater positive correlation within the left inferior prefrontal cortex (BA46) in the FEP group relative to controls, and significantly greater negative correlation within the left parahippocampal gyrus in the control group relative to FEP patients.


CONCLUSIONS
Our results indicate that cognitive deficits are directly related to brain volume abnormalities in frontal and temporo-parietal cortices in FEP subjects, most specifically in inferior portions of the dorsolateral prefrontal cortex.
Minatogawa-Chang
Taís M
TM
Department of Psychiatry, University of São Paulo Medical School, Rua Ovídio Pires Campos, São Paulo, Brazil. tais.minatogawa@gmail.com
Schaufelberger
Maristela S
MS
Ayres
Adriana M
AM
Duran
Fábio L S
FL
Gutt
Elisa K
EK
Murray
Robin M
RM
Rushe
Teresa M
TM
McGuire
Philip K
PK
Menezes
Paulo R
PR
Scazufca
Marcia
M
Busatto
Geraldo F
GF
D000328:Adult; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000473:pathology* / Q000503:physiopathology; D003072:Cognition Disorders / Q000209:etiology* / Q000473:pathology*; D018672:Community Health Planning / Q000379:methods; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009483:Neuropsychological Tests; D025341:Principal Component Analysis; D012559:Schizophrenia / Q000150:complications* / Q000473:pathology*; D013223:Statistics as Topic; D055815:Young Adult