title: Spontaneous resolution of macular edema after panretinal photocoagulation in florid proliferative diabetic retinopathy.
abstract: OBJECTIVE
  To report the evolution of diabetic macular edema (DME) after extensive panretinal photocoagulation in patients with Type 1 diabetes exhibiting florid proliferative diabetic retinopathy (FPDR).
  
  
  METHODS
  This retrospective observational case series comprised 17 eyes of 10 consecutive patients (8 women and 2 men). All patients exhibited FPDR combined with severe DME, and all underwent panretinal photocoagulation. The evolution of visual acuity and progression of FPDR were evaluated. The evolution of DME during follow-up was assessed by fluorescein angiography and repeated optical coherence tomography examinations.
  
  
  RESULTS
  At baseline, all eyes had diffuse DME. Mean logMAR visual acuity was 0.402 +/- 0.46. Mean central macular thickness was 468.23 +/- 113.63 microm. After panretinal photocoagulation, DME regressed spontaneously in all eyes after a mean follow-up of 7.1 +/- 2.68 months. Mean central macular thickness decreased to 268.12 +/-54.67 microm (t-test, P < 0.0001). Mean visual acuity improved significantly to 0.184 +/- 0.12 (t-test, P = 0.048). Diabetic macular edema only recurred in two eyes.
  
  
  CONCLUSIONS
  In DME combined with FPDR, extensive panretinal photocoagulation and glycemic control seem effective in reducing DME and improving vision. In FPDR, DME may be caused by excessive production of vascular endothelial growth factor by the unperfused retina.
authors.affiliation: Service d'Ophtalmologie du Nouvel Hopital Civil, Hopitaux Universitaires de Strasbourg, Strasbourg, France. david.gaucher@chru-strasbourg.fr
authors.forename: David
authors.initials: D
authors.lastname: Gaucher
authors.forename: Pina
authors.initials: P
authors.lastname: Fortunato
authors.forename: Amélie
authors.initials: A
authors.lastname: LeCleire-Collet
authors.forename: Tristan
authors.initials: T
authors.lastname: Bourcier
authors.forename: Claude
authors.initials: C
authors.lastname: Speeg-Schatz
authors.forename: Ramin
authors.initials: R
authors.lastname: Tadayoni
authors.forename: Pascale
authors.initials: P
authors.lastname: Massin
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure / Q000502:physiology; D003922:Diabetes Mellitus, Type 1 / Q000150:complications; D003930:Diabetic Retinopathy / Q000601:surgery*; D018450:Disease Progression; D005260:Female; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D017075:Laser Coagulation; D008269:Macular Edema / Q000209:etiology / Q000503:physiopathology*; D008297:Male; D012075:Remission, Spontaneous; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human