The relation between open-field and emergence tests in a hyperactive mouse model.
The relation between open-field and emergence tests was examined in mice with idiopathic hypertension. Spontaneous hypertensive mice (SHM) crossed more segments and reared more often in the open-field than normotensive controls at both age levels. In contrast, grooming episodes decreased only in the older SHM cohort. While young SHM emerged more quickly from a toy object only partially, complete emergence was faster only in the older SHM cohort. In the entire series, open-field segments were inversely correlated with 2- and 4-paw emergence latencies. There was also an inverse correlation between rears and 2-paw emergence but a positive correlation between grooming episodes and both types of emergence. In view of its association with open-field activity, the emergence test may have value in screening potential ADHD therapies.
Lalonde
R
R
Centre Hospitalier de l'Université de Montréal/St-Luc, Unité de Recherche en Sciences Neurologiques, Montréal, Canada H2X 3J4. robert.lalonde@umontreal.ca
Strazielle
C
C
D000367:Age Factors; D000818:Animals; D001289:Attention Deficit Disorder with Hyperactivity / Q000523:psychology*; D004195:Disease Models, Animal; D005106:Exploratory Behavior; D005260:Female; D006120:Grooming; D006973:Hypertension / Q000523:psychology*; D008297:Male; D051379:Mice; D011930:Reaction Time; D012044:Regression Analysis