title: Never go to sleep on undrained pus: a retrospective review of surgery for intraparenchymal cerebral abscess.
abstract: Cerebral abscess is an emergency requiring urgent drainage via craniotomy or burrhole aspiration. We examine whether initial method of drainage affects outcome and important characteristics in patients with cerebral abscess. This is a retrospective analysis of 62 patients operated on in our unit with a loculated infected cerebral collection in the years 2003-2007 inclusive. Full statistical analysis was performed using data appropriate tests. Burrhole and craniotomy groups were evenly matched with no difference in any demographic factors. Surgical method made no difference to rate of re-operation (p = 0.276), antibiotic duration (p = 0.648), discharge GCS (p = 0.509), length of stay (p = 0.647) or GOS (p = 0.968). There was a trend to worsened outcome with delay to surgery (p = 0.132) with delayed patients requiring longer hospital stays (p < or = 0.005). Patients requiring a longer antibiotic duration had worse outcomes (p < or = 0.005). Surgical method did not have a significant effect on outcome, so burrhole aspiration with its advantages in terms of speed and scale of surgery should be strongly considered. Delay had an adverse affect, so operation should be as expeditious as possible whenever the differential diagnosis includes abscess, diagnosis of which may be aided by advanced magnetic resonance imaging techniques.
authors.affiliation: Department of Neurosurgery, Queen's Medical Centre, Nottingham University Hospitals, Nottingham, United Kingdom. sjsmith@doctors.net.uk
authors.forename: S J
authors.initials: SJ
authors.lastname: Smith
authors.forename: I
authors.initials: I
authors.lastname: Ughratdar
authors.forename: D C
authors.initials: DC
authors.lastname: MacArthur
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D001230:Aspergillus / Q000302:isolation & purification; D001922:Brain Abscess / Q000175:diagnosis / Q000188:drug therapy / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D003399:Craniotomy; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods; D004322:Drainage / Q000379:methods*; D005260:Female; D023261:Glasgow Outcome Scale; D006801:Humans; D008297:Male; D008875:Middle Aged; D012086:Reoperation / Q000706:statistics & numerical data; D012189:Retrospective Studies; D034364:Streptococcus milleri Group / Q000302:isolation & purification; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014207:Trephining; D055815:Young Adult
chemical_list: D000890:Anti-Infective Agents