Inhibitory effect of methyl ethyl ketone upon the enhancement of cerebral blood flow during status epilepticus induced by lithium-pilocarpine.
Significant increases in local cerebral blood flow during lithium-pilocarpine (Li-P) induced seizure have been reported. We recently found that both acetone and methyl ethyl ketone (MEK) showed anticonvulsive effects in status epilepticus induced by Li-P in rats. In this study, we examined whether MEK also suppressed the enhancement of local cerebral blood flow induced by Li-P with a simplified autoradiographic method using [(14)C]-para-iodo-N-isopropyl amphetamine ([(14)C]-IMP). Significant increases in local cerebral blood flow in the thalamus, hypothalamus, hippocampus and cerebellum were observed in Li-P induced status epilepticus rats. Pretreatment with MEK (8 mmol/kg) completely suppressed the enhancement of local cerebral blood flow to or below the control level in all regions.
Sugiyama
Eriko
E
Division of Health Sciences, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.
Matsuki
Yuina
Y
Momosaki
Sotaro
S
Hosoi
Rie
R
Hasebe
Nobuyoshi
N
Abe
Kohji
K
Inoue
Osamu
O
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology* / Q000627:therapeutic use; D001345:Autoradiography; D002074:Butanones / Q000494:pharmacology* / Q000627:therapeutic use; D002250:Carbon Radioisotopes; D002531:Cerebellum / Q000098:blood supply; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D006624:Hippocampus / Q000098:blood supply; D007031:Hypothalamus / Q000098:blood supply; D020367:Iofetamine / Q000378:metabolism; D018021:Lithium Chloride; D008297:Male; D010862:Pilocarpine; D051381:Rats; D017208:Rats, Wistar; D013226:Status Epilepticus / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D013788:Thalamus / Q000098:blood supply
D000927:Anticonvulsants; D002074:Butanones; D002250:Carbon Radioisotopes; D010862:Pilocarpine; C005222:methylethyl ketone; D020367:Iofetamine; D018021:Lithium Chloride