Lipid profile in oral submucous fibrosis.
BACKGROUND
Changes in lipid profile have long been associated with malignancies as lipids play a key role in maintenance of cell integrity. This study evaluated the alterations in extended lipid profile in untreated patients of oral submucous fibrosis (OSMF) and studied the correlation between lipid levels with tobacco consumption.


METHODS
In this hospital-based study, 65 clinically diagnosed and histopathologically proven patients of OSMF and 42 age and sex matched controls were studied. In these samples serum lipids including: (i) Total cholesterol, (ii) LDL cholesterol (LDLC), (iii) HDL cholesterol (HDLC) (iv) VLDL cholesterol (VLDLC) (v) triglycerides (vi) Apo-A1 (viii) Apo-B and (viii) LPa were analyzed.


RESULTS
A significant decrease in plasma total cholesterol, HDLC and Apo-A1 was observed in patients with OSMF as compared to the controls. Thus an inverse relationship between plasma lipid levels and patients was found in OSMF.


CONCLUSIONS
The lower levels of plasma cholesterol and other lipid constituents in patients might be due to their increased utilization. The findings strongly warrant an in-depth study of alterations in plasma lipid profile in patients with oral precancerous conditions.
Mehrotra
Ravi
R
Department of Pathology, M.L.N. Medical College, Allahabad, India. rm8509@gmail.com
Pandya
Shruti
S
Chaudhary
Ajay Kumar
AK
Singh
Himanshu Pratap
HP
Jaiswal
Ritesh Kumar
RK
Singh
Mangal
M
Gupta
S C
SC
Singh
Mamta
M
D000293:Adolescent; D000328:Adult; D016632:Apolipoprotein A-I / Q000097:blood; D001055:Apolipoproteins B / Q000097:blood; D016022:Case-Control Studies; D002648:Child; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007194:India; D008055:Lipids / Q000097:blood*; D017270:Lipoprotein(a) / Q000097:blood; D008297:Male; D008875:Middle Aged; D009914:Oral Submucous Fibrosis / Q000097:blood* / Q000209:etiology; D011230:Precancerous Conditions / Q000097:blood / Q000209:etiology; D012907:Smoking; D019966:Substance-Related Disorders / Q000097:blood*; D055815:Young Adult
D016632:Apolipoprotein A-I; D001055:Apolipoproteins B; D008055:Lipids; D017270:Lipoprotein(a)