title: Turn-over of meningeal and perivascular macrophages in the brain of MCP-1-, CCR-2- or double knockout mice.
abstract: Perivascular and meningeal macrophages are important for immune surveillance in the healthy and the injured brain. Monocyte chemoattractant protein-1 (MCP-1) regulates macrophage migration and permeability of the blood brain barrier. In the present study, we investigated the influence of MCP-1 or/and chemokine receptor 2 (CCR2)-deficiency on macrophage turnover. The results showed no influence of single MCP-1- or CCR-2-deficiency, but double-deficient mice revealed a virtual absence of blood-borne macrophage recruitment. This finding emphasizes that the MCP-1/CCR2 axis is crucially important for macrophage turnover and compensatory mechanisms remain only partially sufficient to sustain regulatory functions.
authors.affiliation: Department of Neurology, University Hospital Münster, Münster, Germany. schillim@uni-muenster.de
authors.forename: Matthias
authors.initials: M
authors.lastname: Schilling
authors.forename: Jan-Kolja
authors.initials: JK
authors.lastname: Strecker
authors.forename: E Bernd
authors.initials: EB
authors.lastname: Ringelstein
authors.forename: Reinhard
authors.initials: R
authors.lastname: Kiefer
authors.forename: Wolf-Rüdiger
authors.initials: WR
authors.lastname: Schäbitz
mesh_terms: D000818:Animals; D000943:Antigens, Differentiation / Q000378:metabolism; D018932:Chemokine CCL2 / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D049452:Green Fluorescent Proteins / Q000235:genetics; D008264:Macrophages / Q000378:metabolism*; D008578:Meninges / Q000166:cytology*; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D054390:Receptors, CCR2 / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*
chemical_list: D000943:Antigens, Differentiation; C515335:Ccr2 protein, mouse; D018932:Chemokine CCL2; D054390:Receptors, CCR2; C036763:monocyte-macrophage differentiation antigen; D049452:Green Fluorescent Proteins