Electrospray ionization tandem mass spectrometric characteristics of d4T H-phosphonate and distamycin conjugates.
The study of the dissociation of the protonated molecular species [M+H](+) and selected fragment ions allowed proposals for the main fragmentation pathways of the title compounds. The main fragments are formed by expelling a molecule of thymine, thymidine (d4T) or isopropyl. The most striking feature of the tandem mass (MS/MS) spectra is the cleavage of C-CO bonds between N-methylpyrrole and carbonyl groups in the presence of the amidine. Electrospray ionization is proven to be a good method for the structural characterization and identification of these kinds of compounds.
Ding
Jingjing
J
State Laboratory of Chemical Resource Engineering, Department of Pharmaceutical Engineering, Beijing University of Chemical Technology, Beijing, China.
Qian
Ning
N
Li
Chao
C
Qiao
Renzhong
R
Zhao
Yufen
Y
D019380:Anti-HIV Agents / Q000737:chemistry*; D004214:Distamycins / Q000737:chemistry*; D015394:Molecular Structure; D063065:Organophosphonates / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods; D018119:Stavudine / Q000737:chemistry*; D053719:Tandem Mass Spectrometry / Q000379:methods*
D019380:Anti-HIV Agents; D004214:Distamycins; D063065:Organophosphonates; C030000:stallimycin; D018119:Stavudine