Adolescent idiopathic scoliosis and the single-nucleotide polymorphism of the growth hormone receptor and IGF-1 genes.
The etiology of adolescent idiopathic scoliosis is undetermined despite years of research. A number of hypotheses have been postulated to explain its development, including growth abnormalities. The irregular expression of growth hormone and insulin-like growth factor-1 (IGF-1) may disturb hormone metabolism, result in a gross asymmetry, and promote the progress of adolescent idiopathic scoliosis. Initial association studies in complex diseases have demonstrated the power of candidate gene association. Prior to our study, 1 study in this field had a negative result. A replicable study is vital for reliability. To determine the relationship of growth hormone receptor and IGF-1 genes with adolescent idiopathic scoliosis, a population-based association study was performed. Single nucleotide polymorphisms with potential function were selected from candidate genes and a distribution analysis was performed. A conclusion was made confirming the insufficiency of an association between adolescent idiopathic scoliosis and the single-nucleotide polymorphism of the growth hormone receptor and IGF-1 genes in Han Chinese.
Yang
Yong
Y
Chinese Academy of Medical Sciences, Department of Orthopedics, Peking Union Medical College, Beijing, China.
Wu
Zhihong
Z
Zhao
Taimao
T
Wang
Hai
H
Zhao
Dong
D
Zhang
Jianguo
J
Wang
Yipeng
Y
Ding
Yaozhong
Y
Qiu
Guixing
G
D000293:Adolescent; D002648:Child; D002681:China / Q000453:epidemiology; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology* / Q000235:genetics*; D006801:Humans; D015994:Incidence; D007334:Insulin-Like Growth Factor I / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011986:Receptors, Somatotropin / Q000235:genetics*; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors; D012600:Scoliosis / Q000453:epidemiology* / Q000235:genetics*; D055815:Young Adult
D011986:Receptors, Somatotropin; D007334:Insulin-Like Growth Factor I