[Pre- and probiotics increase host-cell immunological competence, improve bowel movement, and prevent the onset of colon cancer--an analysis based on movements of intestinal microbiota].
The activation of host immunological competence through improvement of the intestinal environment by pre and probiotics has been reported. NK cell activity, the bactericidal phagocytic activities of neutrophils in peripheral blood, and bowel movements and short chain fatty acids (SCFAs) in intestinal microbiota increase after the administration of pre- and probiotics. SCFAs shift to acidosis of the intestinal environment and advance apoptosis. Furthermore, SCFAs promote intestinal peristaltic movements through SCFA receptors such as GPT 41 and GPR43, located in the intestinal epithelium. It is known that the acceleration of intestinal apoptosis prevents the onset of colon cancer. Improvement of the intestinal environment leads to an increase in host-cell immunological competence, bowel movements, and the prevention of colon cancer.
Ohara
Tadashi
T
Department of Gastroenterology, International University of Health and Welfare Hospital, Nasu-shiobara 329-2763, Japan. tohara@iuhw.ac.jp
Yoshino
Keiichi
K
Kitajima
Masaki
M
D003110:Colonic Neoplasms / Q000517:prevention & control*; D005232:Fatty Acids, Volatile / Q000378:metabolism / Q000502:physiology; D005769:Gastrointestinal Motility; D006801:Humans; D007121:Immunocompetence; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000382:microbiology*; D019936:Probiotics / Q000008:administration & dosage*
D005232:Fatty Acids, Volatile