C29 sterols with a cyclopropane ring at C-25 and 26 from the Vietnamese marine sponge Ianthella sp. and their anticancer properties.
Two new C(29) sterols with a cyclopropane ring at C-25 and C-26, petrosterol-3,6-dione (1) and 5alpha,6alpha-epoxy-petrosterol (2), along with petrosterol (3), were isolated from the Vietnamese marine sponge Ianthella sp. The structures of the new compounds were elucidated by comprehensive spectroscopic analyses. Compounds 1-3 showed cytotoxic activities on A549, HL-60, MCF-7, SK-OV-3, and U937 cancer cell lines with IC(50) in the range of 8.4-22.6 microM, whereas compounds 1-3 exhibited only weak cytotoxic activities on HT-29 cell. After HL-60 cells were treated with the compounds, several apoptosis events like chromatin condensation and the increase of the population of sub-G1 hypodiploid cells were observed. These data supported that the compounds might have potential for leukemia treatment.
Nguyen
Huu Tung
HT
College of Pharmacy, Chungnam National University, Daejeon 305-764, Republic of Korea.
Chau
Van Minh
VM
Tran
Thu Ha
TH
Phan
Van Kiem
VK
Hoang
Thanh Huong
TH
Nguyen
Tien Dat
TD
Nguyen
Xuan Nhiem
XN
Tai
Bui Huu
BH
Hyun
Jae-Hee
JH
Kang
Hee-Kyoung
HK
Kim
Young Ho
YH
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002460:Cell Line; D004354:Drug Screening Assays, Antitumor; D018922:HL-60 Cells; D006801:Humans; D011161:Porifera / Q000737:chemistry*; D013261:Sterols / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D014744:Vietnam
C543942:5alpha,6alpha-epoxy-petrosterol; D000970:Antineoplastic Agents; D013261:Sterols; C543940:petrosterol-3,6-dione; C026361:petrosterol