title: Unusual cellular uptake of cytotoxic 4-hydroxymethyl-3-aminoacridine.
abstract: Aminoacridine derivatives display interesting chemical and biological properties in the field of antitumor agents. The synthesis of 4-hydroxymethyl-3-aminoacridine and its iodo labelled analogue allows the study of cell distribution using two innovative, complementary and powerful techniques, real time fluorescence microscopy and dynamic secondary ion mass spectrometry (SIMS). All the data point to lysosomal localization of the active molecule.
authors.affiliation: Faculté de médecine de Lille, IRCL and IMPRT, Inserm U837, Centre Oscar Lambret, Université Lille Nord de France, France.
authors.forename: Paul
authors.initials: P
authors.lastname: Peixoto
authors.forename: Walid
authors.initials: W
authors.lastname: Zeghida
authors.forename: Danièle
authors.initials: D
authors.lastname: Carrez
authors.forename: Ting-Di
authors.initials: TD
authors.lastname: Wu
authors.forename: Nicole
authors.initials: N
authors.lastname: Wattez
authors.forename: Alain
authors.initials: A
authors.lastname: Croisy
authors.forename: Martine
authors.initials: M
authors.lastname: Demeunynck
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Guerquin-Kern
authors.forename: Amélie
authors.initials: A
authors.lastname: Lansiaux
mesh_terms: D000166:Acridines / Q000493:pharmacokinetics* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000493:pharmacokinetics* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002463:Cell Membrane Permeability; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D008247:Lysosomes / Q000378:metabolism*; D008856:Microscopy, Fluorescence; D018629:Spectrometry, Mass, Secondary Ion
chemical_list: C472795:4-hydroxymethyl-3-aminoacridine; D000166:Acridines; D000970:Antineoplastic Agents