Multisite solid catalyst for cascade reactions: the direct synthesis of benzodiazepines from nitro compounds.
Substituted 1,5-benzodiazepines are selectively synthesized in one pot from substituted nitroaromatics and ketones. The reaction is performed in the presence of hydrogen and in the absence of solvent by using a bifunctional solid catalyst with a chemoselective hydrogenation functional group capable of reducing the nitro group to a diamino group and an acid functional group, which catalyzes the cyclocondensation of the amino group with the ketone.
Climent
Maria J
MJ
Instituto de Tecnología Química (UPV-CSIC), Universidad Politécnica de Valencia, Avenida de los Naranjos s/n, 46022 Valencia, Spain.
Corma
Avelino
A
Iborra
Sara
S
Santos
Laura L
LL
D001569:Benzodiazepines / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D015394:Molecular Structure; D009574:Nitro Compounds / Q000737:chemistry*; D010084:Oxidation-Reduction; D013237:Stereoisomerism
D009574:Nitro Compounds; D001569:Benzodiazepines