Dual phase MIBI scintigraphy in diagnosis of parathyroid adenoma followed by ultrasound guided percutaneous alcoholic ablation.
Primary Hyperparathyroidism (HPT) is an inappropriate hyper secretion of parathyroid hormone (PTH). Primary HPT is caused by parathyroid adenoma in 80-85% of patients. Clinical manifestations are kidney stones, abdominal groans, painful bones, psychic moans, and fatigue overtones. Ultrasonography is widely used in suspected cases for localization of parathyroid adenoma. There is considerable intra-observer variation and it is difficult for ultrasound alone to differentiate parathyroid lesion form that of thyroid. Dual phase Tc-99m MIBI scinitigraphy for detection of parathyroid adenomas has sensitivity and specificity values ranging from 82% to 100% and from 89% to 100%, respectively. Percutaneous ethanol injection for parathyroid glands can be applied effectively in selected cases when surgery is unadvisable either for technical reasons (e.g., recurrence ofhyperplastic glands in the neck after subtotal surgery or intrathyroideal parathyroid tumors or the poor clinical state of the patient.
Ahmad
Shakil
S
Department of Nuclear Medicine, Institute of Nuclear Medicine, Oncology and Radiotherapy, Mansehra Road Abbottabad, Pakistan. drshakilahmad@yahoo.com
Jielani
Amjad Aziz Khan Asif
AA
Khan
Kamran
K
Fatima
Tatheer
T
Zia
Nadeem
N
ud Duha
Mazhar
M
Samad
Abdul
A
Memon
Khalid
K
D000236:Adenoma / Q000000981:diagnostic imaging* / Q000628:therapy*; D000328:Adult; D017115:Catheter Ablation / Q000379:methods*; D000431:Ethanol / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D010282:Parathyroid Neoplasms / Q000000981:diagnostic imaging* / Q000628:therapy*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D017256:Technetium Tc 99m Sestamibi; D018084:Ultrasonography, Interventional
D019275:Radiopharmaceuticals; D000431:Ethanol; D017256:Technetium Tc 99m Sestamibi