title: Whole gastrointestinal transit time is associated with clinical severity and nutritional status of HIV-infected children.
abstract: BACKGROUND
  Malnutrition and malabsorption are common consequences in pediatric human immunodeficiency virus (HIV) infection. The gastrointestinal tract is a major site affected by HIV Rapid gastrointestinal transit time may contribute to malabsorption.
  
  
  OBJECTIVE
  To determine whether the whole gastrointestinal transit time (WGTT) correlates with disease stages or degrees of malnutrition in HIV-infected children.
  
  
  METHODS
  Forty HIV-seropositive children, at various stages of disease, and thirty seronegative age-matched controls, aged between 1 mo and 3 yr, were enrolled in the present study. The body weight, length, or height and the WGTT were assessed Then the WGTT of children in different stages of HIV disease and in different degrees of malnutrition were compared with those of the control group.
  
  
  RESULTS
  The mean ages were 15.5 and 14.3 mo in HIV-infected and control groups respectively. A greater degree of malnutrition was found in HIV-infected children with more advances HIV clinical symptoms. Compared to controls, WGTT was most rapid in severely symptomatic acquired immunodeficiency syndrome (AIDS) patients (Category C) (14.32 +/- 3.88 versus 7.22 +/- 3.17 h; p < 0.01) but not in asymptomatic, mildly and moderately symptomatic children. Accelerated WGTT in HIV-infected children was also significantly associated with a higher degree of malnutrition.
  
  
  CONCLUSIONS
  Malnutrition is clearly related to the progression ofHIV disease. Accelerated WGTT is associated with HIV seropositivity, severe clinical symptoms, and higher degrees of malnutrition.
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
authors.forename: Narumon
authors.initials: N
authors.lastname: Densupsoontorn
authors.forename: Patchaya
authors.initials: P
authors.lastname: Issaragraiseel
authors.forename: Nuchnoi
authors.initials: N
authors.lastname: Thamonsiri
authors.forename: Renu
authors.initials: R
authors.lastname: Wongarn
authors.forename: Pipop
authors.initials: P
authors.lastname: Jirapinyo
mesh_terms: D018450:Disease Progression; D005260:Female; D005772:Gastrointestinal Transit / Q000502:physiology*; D018023:HIV Seronegativity / Q000502:physiology; D006679:HIV Seropositivity / Q000150:complications / Q000503:physiopathology*; D006801:Humans; D007223:Infant; D007228:Infant Nutrition Disorders / Q000209:etiology; D009752:Nutritional Status; D011502:Protein-Energy Malnutrition / Q000209:etiology