Catalyst-Dependent Syntheses of Phosphatidylinositol-5 Phosphate-DiC8 and its Enantiomer.
Peptide-based catalysts have been applied to the enantioselective syntheses of the title compounds, with this being the first report of the synthesis of an ent-PI5P analogue. The key steps in the synthesis involve asymmetric phosphorylation catalysis. Additional maneuvers were developed with a protecting groups scheme that enabled efficient, streamlined syntheses of these important mediators of biochemical events.
Kayser-Bricker
Katherine J
KJ
Department of Chemistry, Yale University, P. O. Box 208107, New Haven, CT 06520.
Jordan
Peter A
PA
Miller
Scott J
SJ