Evaluation of the expression of interleukin 1 beta (IL-1beta) and interleukin 1 receptor antagonist (IL-1Ra) in leprosy patients.
Leprosy is an infectious and contagious spectral disease accompanied by a series of immunological events triggered by the host's response to the etiologic agent, Mycobacterium leprae. Evidence suggests that the induction and maintenance of the immune/inflammatory response in leprosy are linked to multiple cell interactions and soluble factors, mainly through the action of cytokines. The ELISA test was used to measure the levels of IL-1beta and IL-1Ra in 37 new leprosy patients followed-up during treatment and 30 healthy controls. Peripheral blood was collected four times during the treatment of leprosy patients (MDT pretreatment, 2nd dose, 6th dose and post-MDT), and only once from the controls. The comparison of molecular levels in pre-MDT patients and controls showed a statistically significant difference for IL-1beta. The results suggest the participation of this cytokine in the genesis of the immune/inflammatory process.
Costa
Rosane Dias
RD
Santa Casa de Misericórdia de Belo Horizonte, MG, Brazil. costa.rosane@uol.com.br
Mendonça
Vanessa Amaral
VA
Lyon
Sandra
S
Penido
Rachel Adriana
RA
Costa
Ana Maria Duarte Dias
AM
Costa
Marina Dias
MD
Nishi
Marina Pires
MP
Teixeira
Mauro Martins
MM
Teixeira
Antônio Lúcio
AL
Antunes
Carlos Maurício de Figueiredo
CM
D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein / Q000097:blood*; D053583:Interleukin-1beta / Q000097:blood*; D007918:Leprosy / Q000097:blood* / Q000188:drug therapy; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D012372:ROC Curve
D053590:Interleukin 1 Receptor Antagonist Protein; D053583:Interleukin-1beta