title: Avermectin intoxication with coma, myoclonus, and polyneuropathy.
abstract: BACKGROUND
  Avermectin has been used in the control of parasites and insects. Severe poisoning symptoms in humans include altered mental status, hypotension, and respiratory failure.
  
  
  METHODS
  We describe a case of acute avermectin intoxication at a very high dose (414.2 mg/kg) who presented with coma, myoclonus, and polyneuropathy after oral ingestion.
  
  
  CONCLUSIONS
  The symptoms are supposed to be associated directly with the avermectin poisoning and possibly with the toxicity of solvents or other additives.
  
  
  CONCLUSIONS
  To the best of our knowledge, this is the first case with avermectin poisoning associated with myoclonus and polyneuropathy in the literature.
authors.affiliation: Department of Neurology, Tri-Service General Hospital, Taipei, Taiwan, Republic of China. sungyf@ndmctsgh.edu.tw
authors.forename: Yueh-Feng
authors.initials: YF
authors.lastname: Sung
authors.forename: Chuang-Ti
authors.initials: CT
authors.lastname: Huang
authors.forename: Cheng-Kuo
authors.initials: CK
authors.lastname: Fan
authors.forename: Chih-Hung
authors.initials: CH
authors.lastname: Lin
authors.forename: Shiou-Ping
authors.initials: SP
authors.lastname: Lin
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D003128:Coma / Q000139:chemically induced* / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D007306:Insecticides / Q000506:poisoning*; D007559:Ivermectin / Q000031:analogs & derivatives* / Q000506:poisoning; D008297:Male; D009207:Myoclonus / Q000139:chemically induced* / Q000503:physiopathology / Q000628:therapy; D017933:Peripheral Nervous System / Q000187:drug effects / Q000503:physiopathology; D011041:Poisoning / Q000150:complications* / Q000503:physiopathology / Q000628:therapy; D011115:Polyneuropathies / Q000139:chemically induced* / Q000503:physiopathology / Q000628:therapy; D013406:Suicide, Attempted
chemical_list: D007306:Insecticides; D007559:Ivermectin; C019264:avermectin