Outbreak of life-threatening coxsackievirus B1 myocarditis in neonates.
In the summer and fall of 2007, we observed a unique cluster of cases of severe coxsackievirus B1 (CVB1) infection among Chicago area neonates. Eight neonates had closely related strains of CVB1 that were typed at the Centers of Disease Control and Prevention; 2 other neonates had CVB infections, 1 of which was further identified as serotype CVB1. All had severe myocarditis; 1 neonate underwent heart transplantation, and 1 died of severe left ventricular dysfunction.
Verma
Natasha A
NA
Divisions of Infectious Diseases, Children's Memorial Hospital, Chicago, Illinois, USA. nverma@chla.usc.edu
Zheng
Xiaotian T
XT
Harris
Michelle U
MU
Cadichon
Sandra B
SB
Melin-Aldana
Hector
H
Khetsuriani
Nino
N
Oberste
M Steven
MS
Shulman
Stanford T
ST
D002641:Chicago / Q000453:epidemiology; D016000:Cluster Analysis; D003384:Coxsackievirus Infections / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology; D004196:Disease Outbreaks; D029822:Enterovirus B, Human / Q000145:classification* / Q000302:isolation & purification / Q000472:pathogenicity; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009205:Myocarditis / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology / Q000821:virology*; D012703:Serotyping