A family-based association study of DNA sequence variants in GRM7 with schizophrenia in an Indonesian population.
We previously reported genome-wide significant linkage to chromosome 3p in a sib-pair family sample from Indonesia. A promising candidate gene within the linked region is the metabotropic glutamate receptor subtype 7 (GRM7), involved in glutamatergic neurotransmission. We genotyped 18 single nucleotide polymorphisms in GRM7 in the sample of 124 Indonesian sib-pair families that had provided the significant linkage finding. Transmission disequilibrium analysis revealed nominally significant transmission distortion of rs17031835 in intron 1 of GRM7 (p=0.004, before correction for multiple testing), along with haplotypes containing rs17031835. No other single marker was found to be significantly associated with schizophrenia in our sample. The results from our study provide support for the idea that glutamatergic neurotransmission and specifically the GRM7 gene might be relevant to the development of schizophrenia. Further studies supporting this finding are warranted.
Ganda
Clarissa
C
Western Australian Institute for Medical Research, Centre for Medical Research, University of Western Australia, Perth, WA, Australia. dieter.wildenauer@uwa.edu.au
Schwab
Sibylle G
SG
Amir
Nurmiati
N
Heriani
Heriani
H
Irmansyah
Irman
I
Kusumawardhani
Agung
A
Nasrun
Martina
M
Widyawati
Ika
I
Maier
Wolfgang
W
Wildenauer
Dieter B
DB
D044466:Asian People / Q000235:genetics*; D002893:Chromosomes, Human, Pair 3; D004252:DNA Mutational Analysis; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006239:Haplotypes; D006801:Humans; D007214:Indonesia; D007438:Introns; D015810:Linkage Disequilibrium; D010375:Pedigree; D020641:Polymorphism, Single Nucleotide; D018094:Receptors, Metabotropic Glutamate / Q000235:genetics*; D012559:Schizophrenia / Q000208:ethnology / Q000235:genetics*
D018094:Receptors, Metabotropic Glutamate; C102719:metabotropic glutamate receptor 7