title: [Pharmacodynamic interaction model and its clinical application].
abstract: In clinical anesthetic practice, anesthetists usually use two or more drugs to achieve anesthetized state. For appropriate administration, anesthetists must understand interactions between drugs. In order to quantitatively describe drug interactions, researchers have established a large variety of pharmacodynamic interaction models. So far, the widely-applied models are Isobolograms and Logistic regression model. Recently, a new pharmacodynamic interaction model that adopts response surface methodology has been used to investigate drug interactions; it has been noted to be of great value in anesthetic practice.
authors.affiliation: Laboratory of Anesthesia and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Min
authors.initials: M
authors.lastname: Tang
authors.forename: Wensheng
authors.initials: W
authors.lastname: Zhang
mesh_terms: D000465:Algorithms; D000777:Anesthetics / Q000493:pharmacokinetics / Q000494:pharmacology*; D003198:Computer Simulation; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004357:Drug Synergism; D006801:Humans; D016015:Logistic Models
chemical_list: D000777:Anesthetics