Antimicrobial resistance in gram-negative hospital isolates: results of the Turkish HITIT-2 Surveillance Study of 2007.
Resistance rates to amikacin, ciprofloxacin, ceftazidime, cefepime, imipenem, cefoperazone/sulbactam and piperacillin/tazobactam in Escherichia coli (n= 438), Klebsiella pneumoniae (n= 444), Pseudomonas aeruginosa (n= 210) and Acinetobacter baumanni (n=200) were determined with e-test in a multicenter surveillance study (Hitit-2) in 2007. ESBL production in Escherichia coli and K. pneumoniae was investigated following the CLSI guidelines. Overall 42.0% of E.coli and 41.4% of K. pneumoniae were ESBL producers. In E. coli , resistance to imipenem was not observed, resistance to ciprofloxacin and amikacin was 58.0% and 5.5% respectively. In K. pneumoniae resistance to imipenem, ciprofloxacin and amikacin was 3.1%, 17.8% 12.4% respectively. In P. aeruginosa the lowest rate of resistance was observed with piperacillin/tazobactam (18.1%). A. baumanni isolates were highly resistant to all the antimicrobial agents, the lowest level of resistance was observed against cefoperazone/sulbactam (52.0%) followed by imipenem (55.5%). this study showed that resistance rates to antimicrobials are high in nosocomial isolates and show variations among the centers.
Gur
D
D
Hacettepe University, School of Medicine, Clinical Microbiology Laboartory, Ankara, Turkey.
Hascelik
G
G
Aydin
N
N
Telli
M
M
Gültekin
M
M
Ogülnç
D
D
Arikan
O A
OA
Uysal
S
S
Yaman
A
A
Kibar
F
F
Gülay
Z
Z
Sumerkan
B
B
Esel
D
D
Kayacan
C B
CB
Aktas
Z
Z
Soyletir
G
G
Altinkanat
G
G
Durupinar
B
B
Darka
O
O
Akgün
Y
Y
Yayla
B
B
Gedikoglu
S
S
Sinirtas
M
M
Berktas
M
M
Yaman
G
G
D000890:Anti-Infective Agents / Q000494:pharmacology*; D024901:Drug Resistance, Multiple, Bacterial; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000201:enzymology / Q000302:isolation & purification; D016905:Gram-Negative Bacterial Infections / Q000453:epidemiology / Q000382:microbiology*; D006801:Humans; D007362:Intensive Care Units; D008826:Microbial Sensitivity Tests; D011159:Population Surveillance; D014421:Turkey / Q000453:epidemiology; D001618:beta-Lactamases / Q000378:metabolism
D000890:Anti-Infective Agents; D001618:beta-Lactamases