Mapping of the full length and the truncated interleukin-18 receptor alpha in the mouse brain.
The cytokine IL-18 acts on the CNS both in physiological and pathological conditions. Its action occurs through the heterodimeric receptor IL-18Ralpha\beta. To better understand IL-18 central effects, we investigated in the mouse brain the distribution of two IL-18Ralpha transcripts, a full length and an isoform lacking the intracellular domain hypothesized to be a decoy receptor. Both isoforms were expressed in neurons throughout the brain primarily with overlapping distribution but also with some unique pattern. These data suggest that IL-18 may modulate neuronal functions and that its action may be regulated through expression of a decoy receptor.
Alboni
Silvia
S
Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy. salboni@unimore.it
Cervia
Davide
D
Ross
Brendon
B
Montanari
Claudia
C
Gonzalez
Alejandro Sanchez
AS
Sanchez-Alavez
Manuel
M
Marcondes
Maria Cecilia Garibaldi
MC
De Vries
David
D
Sugama
Shuei
S
Brunello
Nicoletta
N
Blom
Joan
J
Tascedda
Fabio
F
Conti
Bruno
B
D017398:Alternative Splicing; D000818:Animals; D001921:Brain / Q000276:immunology / Q000378:metabolism*; D002531:Cerebellum / Q000378:metabolism; D002540:Cerebral Cortex / Q000378:metabolism; D005091:Exons; D006624:Hippocampus / Q000378:metabolism; D007031:Hypothalamus / Q000378:metabolism; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D020382:Interleukin-18 / Q000276:immunology / Q000378:metabolism*; D053727:Interleukin-18 Receptor alpha Subunit / Q000276:immunology / Q000378:metabolism*; D053728:Interleukin-18 Receptor beta Subunit / Q000378:metabolism; D007438:Introns; D051379:Mice; D008810:Mice, Inbred C57BL; D020033:Protein Isoforms; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014158:Transcription, Genetic
D020382:Interleukin-18; D053727:Interleukin-18 Receptor alpha Subunit; D053728:Interleukin-18 Receptor beta Subunit; D020033:Protein Isoforms