title: The fate of monocytes in atherosclerosis.
abstract: Monocytes are the primary inflammatory cell type that infiltrates early atherosclerotic plaques. Their recruitment into plaques drives disease progression. Disease interventions that target monocytes could act at several points: alteration in the phenotype of circulating monocyte subpopulations; reduced recruitment of monocytes into plaques; alterations in the survival of monocyte-derived cells in atherosclerosis; and promotion of migratory egress from plaques to bring about resolution of the plaque inflammatory response. All of these points of intervention will be briefly discussed in this article.
authors.affiliation: Department of Gene and Cell Medicine, and the Immunology Institute, Mount Sinai School of Medicine, New York, NY 10029, USA. gwendalyn.randolph@mssm.edu
authors.forename: G J
authors.initials: GJ
authors.lastname: Randolph
mesh_terms: D050197:Atherosclerosis / Q000473:pathology*; D002634:Chemotaxis, Leukocyte / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000276:immunology; D009000:Monocytes / Q000276:immunology* / Q000473:pathology