An electrophysiological method for quantifying neuropathic pain behaviors in rats: measurement of hindlimb withdrawal EMG magnitude.
In behavior methods to quantify neuropathic pain, visual observations of limb-withdrawal reflexes to stimuli are not always clear-cut, so this method is partly subjective. Our current data suggest that measurement of electrophysiological EMG magnitudes enables more reliable and objective assessment for quantifying nocifensive behaviors related to neuropathic pain.
Kim
Hee Young
HY
Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX 77555-1069, USA.
Gwak
Young Seob
YS
Shim
Insop
I
D000818:Animals; D001522:Behavior, Animal; D004576:Electromyography / Q000379:methods*; D055724:Electrophysiological Phenomena; D005240:Feasibility Studies; D006614:Hindlimb / Q000502:physiology; D035002:Lower Extremity; D008297:Male; D010146:Pain / Q000503:physiopathology / Q000523:psychology*; D010147:Pain Measurement; D010812:Physical Stimulation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012018:Reflex / Q000502:physiology