Antitumor and antimycobacterial activities of cyclopalladated complexes: X-ray structure of [Pd(C2,N-dmba)(Br)(tu)] (dmba=N,N-dimethylbenzylamine, tu=thiourea).
The reactions between [Pd(C(2),N-dmba)(micro-X)](2) (dmba=N,N-dimethylbenzylamine; X=Cl, Br) and thiourea (tu) in the 1:2 molar ratio at room temperature resulted in the mononuclear compounds [Pd(C(2),N-dmba)(Cl)(tu)] (1) and [Pd(C(2),N-dmba)(Br)(tu)] (2), which were characterized by elemental analyses and infrared (IR), (1)H- and (13)C{(1)H} NMR spectroscopies. The crystal and molecular structures of 2 were determined by single-crystal X-ray diffraction. In vitro cytotoxicity assays of the compounds 1, 2, tu, dmba and cisplatin were carried out using two murine tumor cell lines, namely mammary adenocarcinoma (LM3) and lung adenocarcinoma (LP07). The compounds 1, 2, tu and dmba were also tested against Mycobacterium tuberculosis and their MIC values were determined.
Moro
Antonio C
AC
Departamento de Química Geral e Inorgânica, Instituto de Química, UNESP, CEP, 14801-970 Araraquara, SP, Brazil.
Mauro
Antonio E
AE
Netto
Adelino V G
AV
Ananias
Sandra R
SR
Quilles
Marcela B
MB
Carlos
Iracilda Z
IZ
Pavan
Fernando R
FR
Leite
Clarice Q F
CQ
Hörner
Manfredo
M
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000737:chemistry* / Q000494:pharmacology*; D000904:Antibiotics, Antitubercular / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D007259:Infrared Rays; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D010165:Palladium / Q000737:chemistry* / Q000494:pharmacology*; D013890:Thiourea / Q000737:chemistry / Q000494:pharmacology
D000903:Antibiotics, Antineoplastic; D000904:Antibiotics, Antitubercular; D010165:Palladium; D013890:Thiourea