The development of peripartum depressive symptoms is associated with gene polymorphisms of MAOA, 5-HTT and COMT.
BACKGROUND
Polymorphisms of monoamine-related genes have been associated with depression following life events. The peripartum is a physiologically and psychologically challenging period, characterized by fluctuations in depressive symptoms, therefore facilitating prospective investigations in this gene x environment (G x E) interaction.


METHODS
Eighty nine pregnant women filled in two Edinburgh Postpartum Depression Scale (EPDS) questionnaires during pregnancy and two in the postpartum period. MAOA, COMT and 5-HTT polymorphisms were analyzed.


RESULTS
We found a significant interaction between the development of depressive symptoms in the course of pregnancy and polymorphisms in 5-HTT (p=0.019); MAOA (p=0.044) and COMT (p=0.026), and MAOA x COMT (p<0.001). Particularly, women carrying the combination of low activity variants of MAOA and COMT showed increased EPDS scores at week 36 of pregnancy and 6 weeks postpartum, but not during early pregnancy or 12 weeks postpartum.


CONCLUSIONS
We found that MAOA in combination with COMT appears to regulate not only the stress response in laboratory experiments, but also seems to influence the stress-evoked onset of mood during normal, mild, stressful events, such as experienced in the peripartum period. These findings support the GxE concept for depression, but they underline the complexity of this concept, as the cumulating effects of these polymorphic genes (i.e. MAOA+COMT) might be needed and the effects of these polymorphic genes becomes apparent in special environmental or physiological conditions (i.e. the peripartum period). We therefore suggest that G x E interactions become especially noticeable from longitudinal study designs in specific physiological or social challenging periods.
Doornbos
Bennard
B
Graduate School of Behavioral and Cognitive Neuroscience, University Center for Psychiatry, University Medical Center Groningen, The Netherlands. b.doornbos@med.umcg.nl
Dijck-Brouwer
D A Janneke
DA
Kema
Ido P
IP
Tanke
Marit A C
MA
van Goor
Saskia A
SA
Muskiet
Frits A J
FA
Korf
Jakob
J
D000328:Adult; D000704:Analysis of Variance; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D019052:Depression, Postpartum / Q000235:genetics*; D018450:Disease Progression; D004281:Docosahexaenoic Acids; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D005838:Genotype; D006801:Humans; D008995:Monoamine Oxidase / Q000235:genetics*; D011110:Polymorphism, Genetic; D011247:Pregnancy; D011569:Psychiatric Status Rating Scales; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D011795:Surveys and Questionnaires
C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; D004281:Docosahexaenoic Acids; D008995:Monoamine Oxidase; D002394:Catechol O-Methyltransferase