title: In-vitro and in-vivo evaluation of a new Ti-15Mo-1Bi alloy.
abstract: The newly developed Ti-15Mo-1Bi alloy not only possesses all the desirable mechanical properties inherent to beta-Ti Mo alloys, but may even enjoy better clinical applicability with the addition of bismuth element, which has long been administered as antibacterial and antitumor medicines. A significantly higher viability of 3T3 cells was demonstrated when they were grown on Ti-15Mo-1Bi alloy than on Ti-15Mo and Ti-6Al-4V. Cells incubated in the medium conditioned by Bi powder at 37 degrees C for 96 h exhibited viability similar to that in the blank group and higher than that in the Ni conditioned group. In vivo experiments using 6 mm x 2 mm metal pin implanted into the epicondyle of rabbit femur revealed superior potential of new bone growth and better persistence of the deposited bony tissue with the Ti-15Mo-1Bi alloy in contrast to that with Ti-6Al-4V. The difference is evident at 12th week and become even more prominent after 26 weeks, with the new bone area measuring 249% of that around Ti-6Al-4V alloy. In summary, Ti-15Mo-1Bi alloys show no cytotoxicity in the in-vitro test and demonstrates superior ability to retain bone in the in-vivo implantation experiment as compared with Ti-6Al-4V alloys.
authors.affiliation: Division of Plastic Surgery, Department of Surgery, National Cheng-Kung University Medical College and Hospital, Tainan 704, Taiwan, Republic of China.
authors.forename: Jing-Wei
authors.initials: JW
authors.lastname: Lee
authors.affiliation: Department of Dental Hygiene, China Medical University, Taichung 404, Taiwan, Republic of China.
authors.forename: Dan-Jae
authors.initials: DJ
authors.lastname: Lin
authors.affiliation: Department of Materials Science and Engineering, National Cheng-Kung University, Tainan 701, Taiwan, Republic of China.
authors.forename: Chien-Ping
authors.initials: CP
authors.lastname: Ju
authors.affiliation: Department of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei 100, Taiwan, Republic of China.
authors.forename: Hsiang-Shu
authors.initials: HS
authors.lastname: Yin
authors.affiliation: Department of Materials Science and Engineering, National Cheng-Kung University, Tainan 701, Taiwan, Republic of China.
authors.forename: Cheng-Chung
authors.initials: CC
authors.lastname: Chuang
authors.affiliation: Department of Materials Science and Engineering, National Cheng-Kung University, Tainan 701, Taiwan, Republic of China.
authors.forename: Jiin-Huey Chern
authors.initials: JC
authors.lastname: Lin
mesh_terms: D016475:3T3 Cells; D000497:Alloys / Q000737:chemistry* / Q000633:toxicity; D000818:Animals; D001846:Bone Development; D001842:Bone and Bones / Q000166:cytology; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D005269:Femur; D008297:Male; D008422:Materials Testing; D051379:Mice; D008807:Mice, Inbred BALB C; D019736:Prostheses and Implants; D011817:Rabbits; D014025:Titanium / Q000737:chemistry / Q000633:toxicity
chemical_list: D000497:Alloys; C546711:Ti-15Mo-1Bi alloy; C031462:titanium alloy (TiAl6V4); D014025:Titanium