title: Backbone assignment of osteopontin, a cytokine and cell attachment protein implicated in tumorigenesis.
abstract: OPN is an RGD-containing protein overexpressed in cells transformed by v-myc and v-mil(raf) oncogenes. Here we report the resonance assignment of recombinant quail OPN and provide NMR evidence that quail OPN is an intrinsically unstructured protein in solution.
authors.affiliation: Department of Biomolecular Structural Chemistry, Max F. Perutz Laboratories, University of Vienna, Vienna Biocenter Campus 5, 1030 Vienna, Austria.
authors.forename: Andreas
authors.initials: A
authors.lastname: Schedlbauer
authors.forename: Przemyslaw
authors.initials: P
authors.lastname: Ozdowy
authors.forename: Georg
authors.initials: G
authors.lastname: Kontaxis
authors.forename: Markus
authors.initials: M
authors.lastname: Hartl
authors.forename: Klaus
authors.initials: K
authors.lastname: Bister
authors.forename: Robert
authors.initials: R
authors.lastname: Konrat
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002247:Carbon Isotopes / Q000737:chemistry; D015815:Cell Adhesion Molecules / Q000737:chemistry*; D016207:Cytokines / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008969:Molecular Sequence Data; D008970:Molecular Weight; D009369:Neoplasms / Q000378:metabolism; D009587:Nitrogen Isotopes / Q000737:chemistry; D053495:Osteopontin / Q000737:chemistry*; D011522:Protons; D011784:Quail / Q000378:metabolism*
chemical_list: D002247:Carbon Isotopes; D015815:Cell Adhesion Molecules; D016207:Cytokines; D009587:Nitrogen Isotopes; D011522:Protons; D053495:Osteopontin