title: Coronary aneurysm associated with coronary perforation after sirolimus-eluting stents implantation: close follow-up exceeding 2 years by coronary 3-dimensional computed tomography.
abstract: Both coronary perforation and aneurysms associated with sirolimus-eluting stent (SES) implantations are uncommon complications. We describe an unusual case of a coronary aneurysm associated with a coronary perforation after SES implantation. Although their pathogenesis has not yet been completely elucidated, some technical factors including the use of excessive pressure during the stent deployment, and sirolimus-induced vascular inflammatory reactions and poor healing response at the perforation site may be related to the shape of the aneurismal formation. Fortunately and interestingly, the size of the coronary aneurysm gradually decreased, and finally by 26 months a nearly complete resolution of the aneurysm had taken place. Furthermore, close follow-up by coronary 3-dimensional computed tomography (3DCT) could clearly demonstrate the natural course of this aneurysm. To the best of our knowledge, there have been no reports on the natural course of coronary aneurysm associated with a coronary perforation after SES(s) implantation for more than 2 years using coronary 3DCT as in this present case. The phenomenon of the spontaneous resolution of the coronary aneurysm after SES implantation may have clinical therapeutic implications.
authors.affiliation: Department of Cardiovascular Medicine, Kyushu University Hospital, Fukuoka, Japan.
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Eshima
authors.forename: Masao
authors.initials: M
authors.lastname: Takemoto
authors.forename: Shujiro
authors.initials: S
authors.lastname: Inoue
authors.forename: Taiki
authors.initials: T
authors.lastname: Higo
authors.forename: Hideo
authors.initials: H
authors.lastname: Tada
authors.forename: Kenji
authors.initials: K
authors.lastname: Sunagawa
mesh_terms: D000368:Aged; D003323:Coronary Aneurysm / Q000000981:diagnostic imaging* / Q000209:etiology*; D017023:Coronary Angiography; D003331:Coronary Vessels / Q000293:injuries*; D054855:Drug-Eluting Stents / Q000009:adverse effects*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D021621:Imaging, Three-Dimensional; D020123:Sirolimus / Q000008:administration & dosage*; D014057:Tomography, X-Ray Computed
chemical_list: D020123:Sirolimus