Label-free electrochemical detection of adenosine based on electron transfer from guanine bases in an adenosine-sensitive aptamer.
The selective recognition of adenosine with an adenosine-sensitive oligonucleotide is studied via the electrochemical oxidation of guanine bases of the aptamer in solution, leading to a label-free voltammetric aptasensor based on the difference in the oxidative electron transfer rate.
Kim
Jinheung
J
Department of Chemistry and Nano Science, Ewha Womans University, Seoul 120-750, Korea. jinheung@ewha.ac.kr
Kim
In Young
IY
Choi
Min Sun
MS
Wu
Qiong
Q
D000241:Adenosine / Q000737:chemistry; D052157:Aptamers, Nucleotide / Q000737:chemistry*; D001483:Base Sequence; D004563:Electrochemistry / Q000379:methods; D006147:Guanine / Q000737:chemistry*; D008968:Molecular Conformation; D008969:Molecular Sequence Data; D009942:Organometallic Compounds / Q000737:chemistry
D052157:Aptamers, Nucleotide; D009942:Organometallic Compounds; C415768:tris(2,2'-bipyridyl)ruthenium(II); D006147:Guanine; D000241:Adenosine