Is intrinsic asthma synonymous with infection?
Rackemann described the 'intrinsic asthma' population over 50 years ago as a unique subgroup that was characterized by onset of progressive loss of lung function beginning later in life, possibly after a respiratory infection. It has also been associated with a female predominance, aspirin-sensitive bronchospasm, and nasal polyposis. While the aetiology is not understood, we propose that persistent respiratory infections play a central role in the development of intrinsic asthma.
Dahlberg
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PE
Section of Allergy, Pulmonary and Critical Care, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA.
Busse
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WW
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000627:therapeutic use; D001241:Aspirin / Q000009:adverse effects / Q000627:therapeutic use; D001249:Asthma / Q000209:etiology* / Q000276:immunology / Q000503:physiopathology; D001986:Bronchial Spasm / Q000209:etiology / Q000276:immunology / Q000503:physiopathology; D005260:Female; D006801:Humans; D008168:Lung / Q000276:immunology / Q000503:physiopathology; D008297:Male; D009298:Nasal Polyps / Q000150:complications / Q000276:immunology / Q000503:physiopathology; D012141:Respiratory Tract Infections / Q000150:complications* / Q000276:immunology / Q000503:physiopathology; D012737:Sex Factors
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin