Anti-nociceptive and anti-inflammatory activity of sophocarpine.
OBJECTIVE
This study aimed to assess the anti-nociceptive and anti-inflammatory activity of sophocarpine in rodents.


METHODS
The anti-nociceptive effect was evaluated in two experimental animal models and anti-inflammatory effect in three animal models, and sophocarpine was given by tail vein injection for the above study.


RESULTS
Pretreatment with a single dose of sophocarpine (20 and 40 mg/kg) produced dose-dependent anti-nociceptive effects in thermally and chemically induced mouse pain models. Pretreatment with a single dose of sophocarpine also produced significant dose-dependent anti-inflammatory effects on carrageenan-induced rat hind paw edema (15 and 30 mg/kg), xylene-induced mouse ear edema (20 and 40 mg/kg) and acetic acid-induced mouse vascular permeation (20 and 40 mg/kg).


CONCLUSIONS
Sophocarpine possesses peripheral and central analgesic properties as well as anti-inflammatory activity on acute inflammatory processes.
Gao
Yonglin
Y
College of Food Science and Engineering, Ocean University of China, Qingdao Shandong Province 266003, PR China.
Li
Guisheng
G
Li
Chunmei
C
Zhu
Xiaoyin
X
Li
Min
M
Fu
Chaolin
C
Li
Bafang
B
D019342:Acetic Acid; D000470:Alkaloids / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D000700:Analgesics / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D002199:Capillary Permeability / Q000187:drug effects; D002351:Carrageenan; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005260:Female; D007249:Inflammation / Q000188:drug therapy; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy*; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D029909:Sophora / Q000737:chemistry*; D014992:Xylenes; D000093842:Matrines
D019342:Acetic Acid; D000470:Alkaloids; D000700:Analgesics; D000893:Anti-Inflammatory Agents; D002351:Carrageenan; D010936:Plant Extracts; D014992:Xylenes; C035933:sophocarpine; D000093842:Matrines