title: Tausalarin C: a new bioactive marine sponge-derived nitrogenous bismacrolide.
abstract: A novel nitrogenous bismacrolide, designated tausalarin C (1), was isolated from the Madagascar sponge Fascaplysinopsis sp. The structure of the compound was elucidated by interpretation of MS and 1D and 2D NMR spectra. It is suggested that tausalarin C is assembled from salarin A (2) and pretaumycin A. The relative configuration of the chiral centers of salarin A was determined by X-ray diffraction. Tausalarin C was found to inhibit proliferation of K562 leukemia cells. A possible biogenesis is discussed.
authors.affiliation: School of Chemistry, Tel AViV UniVersity, Ramat AViV 69978, Israel.
authors.forename: Ashgan
authors.initials: A
authors.lastname: Bishara
authors.forename: Amira
authors.initials: A
authors.lastname: Rudi
authors.forename: Israel
authors.initials: I
authors.lastname: Goldberg
authors.forename: Maurice
authors.initials: M
authors.lastname: Aknin
authors.forename: Drorit
authors.initials: D
authors.lastname: Neumann
authors.forename: Nathalie
authors.initials: N
authors.lastname: Ben-Califa
authors.forename: Yoel
authors.initials: Y
authors.lastname: Kashman
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020014:K562 Cells; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D018942:Macrolides; C526618:salarin A; C544441:tausalarin C