title: (1)H, (13)C and (15)N backbone assignments for the ligand binding domain of the Pseudomonas aeruginosa virulence regulator LasR.
abstract: LasR regulates toxin production in Pseudomonas aeruginosa and its inhibition can attenuate the virulence of this opportunistic human pathogen. To aid studies of interactions with inhibitors, we report the NMR backbone assignments for the dimeric LasR ligand-binding domain.
authors.affiliation: Istituto di Ricerche di Biologia Molecolare, Pomezia, Roma, Italy. matthew_bottomley@merck.com
authors.forename: Matthew James
authors.initials: MJ
authors.lastname: Bottomley
authors.forename: Ester
authors.initials: E
authors.lastname: Muraglia
authors.forename: Renzo
authors.initials: R
authors.lastname: Bazzo
mesh_terms: D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000737:chemistry*; D002247:Carbon Isotopes / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008970:Molecular Weight; D009587:Nitrogen Isotopes / Q000737:chemistry; D017434:Protein Structure, Tertiary; D011522:Protons; D011550:Pseudomonas aeruginosa / Q000378:metabolism*; D015534:Trans-Activators / Q000737:chemistry*
chemical_list: D001426:Bacterial Proteins; D002247:Carbon Isotopes; C080365:LasR protein, Pseudomonas aeruginosa; D009587:Nitrogen Isotopes; D011522:Protons; D015534:Trans-Activators