title: Insights into angiogenic imbalances during pregnancy.
abstract: BACKGROUND
  An excess of either angiogenic or antiangiogenic factors may participate in the pathophysiology of life-threatening pregnancy complications.
  
  
  METHODS
  We describe two patients with severe early onset preeclampsia associated with partial mole or sacrococcygeal teratoma who had an excess of circulating concentrations of the antiangiogenic factors soluble vascular endothelial growth factor receptor-1 and soluble endoglin. In contrast, a patient with severe ovarian hyperstimulation syndrome at 5 weeks of gestation had an excess of circulating free vascular endothelial growth factor, a key angiogenic factor.
  
  
  CONCLUSIONS
  Angiogenic imbalances may participate in the pathophysiology of early onset preeclampsia associated with partial mole or sacrococcygeal teratoma as well as in the pathophysiology of severe ovarian hyperstimulation syndrome during pregnancy.
authors.affiliation: From the Department of Obstetrics and Gynecology, William Beaumont Hospital, Royal Oak, Michigan.
authors.forename: Jimmy
authors.initials: J
authors.lastname: Espinoza
authors.forename: John E
authors.initials: JE
authors.lastname: Uckele
authors.forename: Robert A
authors.initials: RA
authors.lastname: Starr
authors.forename: Robert P
authors.initials: RP
authors.lastname: Lorenz
authors.forename: Richard A
authors.initials: RA
authors.lastname: Bronsteen
authors.forename: Stanley M
authors.initials: SM
authors.lastname: Berry
mesh_terms: D000328:Adult; D042501:Angiogenic Proteins / Q000097:blood*; D015703:Antigens, CD / Q000097:blood; D000071063:Endoglin; D005260:Female; D006801:Humans; D006828:Hydatidiform Mole / Q000097:blood*; D016471:Ovarian Hyperstimulation Syndrome / Q000097:blood* / Q000209:etiology / Q000473:pathology; D011225:Pre-Eclampsia / Q000097:blood* / Q000209:etiology / Q000473:pathology; D011247:Pregnancy; D011956:Receptors, Cell Surface / Q000097:blood; D012445:Sacrococcygeal Region; D013724:Teratoma / Q000097:blood*; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000097:blood*
chemical_list: D042501:Angiogenic Proteins; D015703:Antigens, CD; C064206:ENG protein, human; D000071063:Endoglin; D011956:Receptors, Cell Surface; D040281:Vascular Endothelial Growth Factor Receptor-1