title: Axonal sensory motor neuropathy in copper-deficient Wilson's disease.
abstract: Copper deficiency may cause myeloneuropathy or progressive limb weakness. By contrast, Wilson's disease (WD) is characterized by progressive copper accumulation with hepatic and neurological impairment and requires life-long treatment with zinc and/or chelator agents. We report a WD patient who developed axonal sensory motor neuropathy in the context of copper deficiency due to his treatment with zinc and chelators. Exhaustive testing for other etiologies was negative. After treatment adjustment, only mild clinical improvement was noted during long-term follow-up. Muscle Nerve 40: 294-296, 2009.
authors.affiliation: Department of Neurology, University Hospital Bordeaux, Haut-Lévêque, Avenue Magellan, 33604 Pessac Cedex, France.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Foubert-Samier
authors.forename: Annabelle
authors.initials: A
authors.lastname: Kazadi
authors.forename: Marie
authors.initials: M
authors.lastname: Rouanet
authors.forename: Anne
authors.initials: A
authors.lastname: Vital
authors.forename: Alain
authors.initials: A
authors.lastname: Lagueny
authors.forename: François
authors.initials: F
authors.lastname: Tison
authors.forename: Wassilios
authors.initials: W
authors.lastname: Meissner
mesh_terms: D000328:Adult; D001369:Axons / Q000502:physiology; D002614:Chelating Agents / Q000009:adverse effects; D003300:Copper / Q000172:deficiency*; D006527:Hepatolenticular Degeneration / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D008297:Male; D009431:Neural Conduction / Q000502:physiology; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology*; D015032:Zinc / Q000009:adverse effects
chemical_list: D002614:Chelating Agents; D003300:Copper; D015032:Zinc