Levels of biochemical bone marker procollagen type I N-propeptide (PINP) in Thai women aged 40-70 years.
OBJECTIVE
To determine reference ranges for serum Procollagen type I N-propeptide (PINP), one of the bone formation markers, in Thai women aged 40-70 years old.


METHODS
PINP was measured in fasting serum of 300 healthy Thai women who had never been diagnosed as osteoporosis. They were divided into 3 groups by age, 100 per each; the first were menstruating women aged 40-50 years, the second were 51-60 year old menopausal women, and the third were 61-70 year old postmenopausal women.


RESULTS
The mean values of PINP with 95% confident interval in groups 1,2,3 were 42.67 (38.74, 46.59), 61.63 (55.94, 67.31) and 60.66 (55.35, 65.96) ng/ml respectively.


CONCLUSIONS
The present study showed PINP levels in Thai women in diferent age and menstrual status. The mean PINP in the postmenopausal group was higher than the premenopausal group, which confirmed postmenopausal women have more bone turnover rate.
Boonyanurak
Pongrak
P
Department of Obstetrics and Gynecology, Phramongkutklao Hospital, Bangkok, Thailand.
Wilawan
Kittisak
K
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010024:Osteoporosis / Q000175:diagnosis; D010446:Peptide Fragments / Q000097:blood*; D017698:Postmenopause / Q000502:physiology; D017697:Premenopause / Q000502:physiology; D011347:Procollagen / Q000097:blood*; D012016:Reference Values; D013785:Thailand
D015415:Biomarkers; D010446:Peptide Fragments; D011347:Procollagen; C047202:procollagen Type I N-terminal peptide