title: Salivary diagnostics.
abstract: The ability to monitor health status, disease onset and progression, and treatment outcome through non-invasive means is a most desirable goal in the health care promotion and delivery. There are three prerequisites to materialize this goal: specific biomarkers associated with a health or disease state; a non-invasive approach to detect and monitor the biomarkers; and the technologies to discriminate the biomarkers. A national initiative catalyzed by the National Institute of Dental & Craniofacial Research (NIDCR) has created a roadmap to achieve these goals through the use of oral fluids as the diagnostic medium to scrutinize the health and/or disease status of individuals. Progress has shown this is an ideal opportunity to bridge state of the art saliva-based biosensors, optimized to disease discriminatory salivary biomarkers, for diagnostic applications. Oral fluid being the 'mirror of body' is a perfect medium to be explored for health and disease surveillance. The translational applications and opportunities are enormous.
authors.affiliation: UCLA Lung Cancer Research Program, Division of Cardiothoracic Surgery, University of California Los Angeles, Los Angeles, CA 90095, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: Lee
authors.forename: E
authors.initials: E
authors.lastname: Garon
authors.forename: D T
authors.initials: DT
authors.lastname: Wong
mesh_terms: D015415:Biomarkers / Q000032:analysis*; D018450:Disease Progression; D006304:Health Status; D006801:Humans; D007202:Indicators and Reagents; D020543:Proteome / Q000032:analysis; D012463:Saliva / Q000737:chemistry*; D012471:Salivary Proteins and Peptides / Q000032:analysis*; D013674:Technology, Dental; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D007202:Indicators and Reagents; D020543:Proteome; D012471:Salivary Proteins and Peptides