title: Chorangiocarcinoma: a case report and review of the literature.
abstract: Chorangiocarcinoma is the name designated to a chorangioma with trophoblastic proliferation manifesting increased proliferative activity. Only 3 such cases have been published so far. Other studies challenged this entity by demonstrating that proliferation of the trophoblast around chorangioma is a common phenomenon. We present a case of a unique vascular lesion in a term placenta with a malignant trophoblastic component. Microscopic examination of a well-demarcated placental mass revealed a chorangioma with multiple nodules composed of pleomorphic cells displaying focal multinucleation, large areas of necrosis, and high mitotic activity. Immunohistochemical stains of these cells were strongly positive for pancytokeratin and the beta subunit of human chorionic gonadotropin and focally positive for HSD3B1. There was no invasion of the basement membrane, and no free-floating tumor cells in the intervillous space. No evidence of metastasis was found on follow-up of the mother and newborn. It is concluded that the tumor presented herein, displaying a histologically unequivocal malignant trophoblastic component in a benign chorangioma, is a true chorangiocarcinoma, and should be included within the category of gestational neoplasia as a tumor closely related to choriocarcinoma.
authors.affiliation: Perinatal Pathology Unit, Hadassah-Hebrew University Medical Center, Mount Scopus, Jerusalem, Israel. ilanaar@ekmd.huji.ac.il
authors.forename: Ilana
authors.initials: I
authors.lastname: Ariel
authors.forename: Raphael
authors.initials: R
authors.lastname: Boldes
authors.forename: Amir
authors.initials: A
authors.lastname: Weintraub
authors.forename: Constantin
authors.initials: C
authors.lastname: Reinus
authors.forename: Uzi
authors.initials: U
authors.lastname: Beller
authors.forename: Revital
authors.initials: R
authors.lastname: Arbel
mesh_terms: D000328:Adult; D003218:Condylomata Acuminata / Q000150:complications; D005260:Female; D006391:Hemangioma / Q000150:complications / Q000648:ultrastructure*; D006801:Humans; D007150:Immunohistochemistry; D009378:Neoplasms, Multiple Primary / Q000150:complications / Q000648:ultrastructure*; D010502:Perineum / Q000473:pathology; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000473:pathology*; D014328:Trophoblastic Neoplasms / Q000150:complications / Q000648:ultrastructure*; D014594:Uterine Neoplasms / Q000150:complications / Q000648:ultrastructure*; D014845:Vulvar Diseases / Q000150:complications