Is increased fat content of hindmilk due to the size or the number of milk fat globules?
BACKGROUND
It is known that the fat content of breast milk is higher in hindmilk than in foremilk. However, it has not been determined if this increased fat content results from an increase in the number of milk fat globules (MFGs), an increase in the size of MFGs, or both. This study aims to determine which factor plays the most important role.


METHODS
Thirteen breastfeeding mothers were enrolled in the study and we obtained 52 samples from 26 breasts before (foremilk) and after (hindmilk) a breastfeeding session. The fat content was evaluated by creamatocrit (CrCt) values. MFG size was measured with the laser light scattering method. We compared CrCt values and MFG size between foremilk and hindmilk.


RESULTS
Although the CrCt values were higher in the hindmilk (8.6 +/- 3.6%) than in the foremilk (3.7 +/- 1.7%), the MFG size did not change (4.2 +/- 1.0 mum and 4.6 +/- 2.1 mum, foremilk and hindmilk, respectively). There was no relationship between the changes in CrCt versus MFG size from foremilk to hindmilk.


CONCLUSIONS
The results indicate that the increase in fat content results mainly from the increased number of MFGs, which may be released into the milk flow as the mammary lobe becomes progressively emptied.
Mizuno
Katsumi
K
Department of Pediatrics, Showa University of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, Japan 142-8666. katsuorobi@med.showa-u.ac.jp.
Nishida
Yoshiko
Y
Taki
Motohiro
M
Murase
Masahiko
M
Mukai
Yoshiharu
Y
Itabashi
Kazuo
K
Debari
Kazuhiro
K
Iiyama
Ai
A