The effect of acute tryptophan depletion on emotional distraction and subsequent memory.
Serotonin is a key neurotransmitter involved in emotional regulation and memory. A number of studies using acute tryptophan depletion (ATD) in healthy subjects have shown that a temporary serotonin reduction both induces a negative emotional bias and impairs long-term memory. However, little is known about the specific effects of ATD on emotional memory. Using functional magnetic resonance imaging (fMRI), we investigated the effect of ATD on negative memory and executive function in healthy volunteers. Our emotional oddball task required participants to distinguish infrequently presented targets from distracting negative and neutral pictures. Memory for the distracting pictures was tested 1 h following the fMRI session. ATD selectively enhanced memory for negative distractors relative to neutral distractors and increased activation in response to the negative distractors in the left orbital-inferior frontal, dorsomedial prefrontal and bilateral angular gyri. ATD also induced greater activation in the left inferior frontal gyrus and anterior cingulate across all stimuli. Stronger frontal activation to distractors was positively correlated with memory performance on ATD but not control days, indicating a possible compensatory mechanism for coping with increased task demand under the ATD challenge. These findings highlight the importance of serotonin in negative memory with implications for mood disorders.
Wang
Lihong
L
Brain Imaging and Analysis Center, Duke University Medical Center, 2424 Erwin Road, Suite 501 Durham, NC 27705, USA. wang@biac.duke.edu
Mullette-Gillman
O'Dhaniel A
OA
Gadde
Kishore M
KM
Kuhn
Cynthia M
CM
McCarthy
Gregory
G
Huettel
Scott A
SA
D000328:Adult; D000339:Affect / Q000502:physiology; D000342:Affective Symptoms / Q000209:etiology*; D000704:Analysis of Variance; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000098:blood supply / Q000502:physiology*; D019587:Dietary Supplements / Q000009:adverse effects; D056344:Executive Function / Q000502:physiology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory / Q000502:physiology*; D009483:Neuropsychological Tests; D010100:Oxygen / Q000097:blood; D010147:Pain Measurement; D011569:Psychiatric Status Rating Scales; D011597:Psychomotor Performance / Q000502:physiology; D013223:Statistics as Topic; D013997:Time Factors; D014364:Tryptophan / Q000097:blood / Q000172:deficiency*; D055815:Young Adult
D014364:Tryptophan; D010100:Oxygen