Association of lipid levels during gestation with preeclampsia and gestational diabetes mellitus: a population-based study.
OBJECTIVE
The study evaluates lipids profile changes during gestation in pregnancies with and without preeclampsia and/or gestational diabetes.


METHODS
Lipid profiles were assessed between year prior and after pregnancy in 9911 women without cardiovascular comorbidities.


RESULTS
Lipid levels during gestation varied substantially with a nadir following conception and a peak at delivery. Compared to preconception levels total cholesterol levels increased from 164.4 mg/dL to 238.6 mg/dL and triglycerides (TGs) from 92.6 mg/dL to 238.4 mg/dL. The composite endpoint (gestational diabetes mellitus or preeclampsia) occurred in 1209 women (12.2%). Its prevalence increased with levels of TG-from 7.2% in the group with low TGs (<25th percentile adjusted for the gestational month) to 19.8% in the group with high TGs (>75th percentile), but was not associated with high-density lipoprotein levels. In multivariate analysis higher TGs levels, but not low high-density lipoprotein, were associated with the primary endpoint.


CONCLUSIONS
Lipid levels change substantially during gestation. Abnormal levels of TGs are associated with pregnancy complications.
Wiznitzer
Arnon
A
Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Be'er-Sheva, Israel.
Mayer
Amit
A
Novack
Victor
V
Sheiner
Eyal
E
Gilutz
Harel
H
Malhotra
Atul
A
Novack
Lena
L
D000328:Adult; D002784:Cholesterol / Q000097:blood*; D003430:Cross-Sectional Studies; D016640:Diabetes, Gestational / Q000097:blood* / Q000453:epidemiology*; D005260:Female; D006801:Humans; D011225:Pre-Eclampsia / Q000097:blood* / Q000453:epidemiology*; D011247:Pregnancy; D014280:Triglycerides / Q000097:blood*
D014280:Triglycerides; D002784:Cholesterol