[Testicular carcinoma and sarcoid-like necrotizing granulomatosis].
A 35-year-old man with a stage I non-seminomatous germ-cell tumor of the right testis was treated with a simple orchidectomy. Sixty-seven months later, the patient who was on clinical follow-up, has presented five bilateral lung nodules on computed-tomography scan. Additional staging showed no other abnormalities. Lung biopsy of two nodules was performed during a videothoracoscopy and the histologic examination revealed a sarcoidosis-like necrotizing granulomatosis. The coexistence of non-caseating granulomas and testis carcinoma showed an increase during the last two decades. The immunopathogenesis of sarcoid formation in malignant tumours is still unknown. During follow-up of patients with testicular carcinomas, the presence of lung nodules requires a histologic examination and sarcoidosis should be considered as differential diagnosis.
Coulibaly
Béma
B
Service d'anatomie pathologique et de neuropathologie, CHU Timone, 13385 Marseille cedex 05, France. bema_coulibaly@yahoo.fr
de Biasi
Cécile
C
Gisserot
Olivier
O
de Jauréguiberry
Jean-Pierre
JP
Patte
Jean-Hugues
JH
D000328:Adult; D003937:Diagnosis, Differential; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000556:secondary; D008297:Male; D009367:Neoplasm Staging; D009919:Orchiectomy; D011183:Postoperative Complications / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D017565:Sarcoidosis, Pulmonary / Q000145:classification / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D013736:Testicular Neoplasms / Q000150:complications* / Q000473:pathology / Q000601:surgery