title: Effects of a bio-assay guided fraction from Polygonum cuspidatum root on the viability, acid production and glucosyltranferase of mutans streptococci.
abstract: Polygonum cuspidatum root has been traditionally used for the treatment of dental diseases in Korea. The purpose of this study was to evaluate effects of P. cuspidatum root on the development of dental caries, especially its effects against bacterial viability and caries-inducing factors of Streptococcus mutans and Streptococcus sobrinus. Among methanol extract of P. cuspidatum root and its fraction tested, ethyl acetate fraction, composed of polydatin, resveratrol, anthraglycoside B, and emodin, showed inhibitory effects on glycolytic acid production and glucosyltransferase activity of S. mutans and S. sobrinus in addition to antibacterial activities.
authors.affiliation: Department of Preventive Dentistry, School of Dentistry, Institute of Oral Bioscience and BK 21 program, Chonbuk National University, Jeonju 561-756, Republic of Korea.
authors.forename: Suk-Ho
authors.initials: SH
authors.lastname: Ban
authors.forename: Young-Ran
authors.initials: YR
authors.lastname: Kwon
authors.forename: Santosh
authors.initials: S
authors.lastname: Pandit
authors.forename: Young-Soo
authors.initials: YS
authors.lastname: Lee
authors.forename: Ho-Keun
authors.initials: HK
authors.lastname: Yi
authors.forename: Jae-Gyu
authors.initials: JG
authors.lastname: Jeon
mesh_terms: D003731:Dental Caries / Q000517:prevention & control*; D045468:Fallopia japonica / Q000737:chemistry*; D005964:Glucosyltransferases / Q000037:antagonists & inhibitors / Q000378:metabolism; D006018:Glycols / Q000037:antagonists & inhibitors / Q000378:metabolism; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009910:Oral Hygiene; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D018517:Plant Roots / Q000737:chemistry; D013295:Streptococcus mutans / Q000187:drug effects* / Q000201:enzymology; D016986:Streptococcus sobrinus / Q000187:drug effects* / Q000201:enzymology
chemical_list: D006018:Glycols; D010936:Plant Extracts; D005964:Glucosyltransferases