title: Relationship between insulin sensitivity index and cognitive function in diet-induced insulin resistant rats.
abstract: Clinical and animal studies have revealed significant cognitive impairment in type II diabetic subjects. However, whether there is a relationship between insulin resistance and cognitive function is poorly understood. In the present study, we used a high fat diet to induce insulin resistance (IR) in rats, insulin sensitivity index (ISI) (= FINS x FPG/22.5) to assess the extent of insulin resistance and the Morris Water Maze Task to judge cognitive function. The relationship between insulin sensitivity index and cognitive function was determined by analysing the correlation between ISI and the time rat spent in targeted quadrant, as well as between ISI and the times the rat swam across the very point where a platform was previously placed, using Pearson's method. Perfect negative correlation between ISI and cognitive function existed when ISI fell within a certain range, which indicates that insulin resistance is associated with cognitive function impairment in some cases where ISI might be an indicator.
authors.affiliation: Department of Pharmacology, China Pharmaceutical University, Nanjing, China.
authors.forename: Sisi
authors.initials: S
authors.lastname: Chen
authors.forename: Hao
authors.initials: H
authors.lastname: Xie
authors.forename: Jing
authors.initials: J
authors.lastname: Wu
authors.forename: Hao
authors.initials: H
authors.lastname: Hong
authors.forename: Jianwen
authors.initials: J
authors.lastname: Jin
authors.forename: Jinbo
authors.initials: J
authors.lastname: Fang
authors.forename: Ji
authors.initials: J
authors.lastname: Huang
authors.forename: Ying Zhou
authors.initials: YZ
authors.lastname: Fu
authors.forename: Hui
authors.initials: H
authors.lastname: Ji
authors.forename: Yong Qi
authors.initials: YQ
authors.lastname: Li
authors.forename: Yan
authors.initials: Y
authors.lastname: Long
authors.forename: Yuan Zheng
authors.initials: YZ
authors.lastname: Xia
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D001786:Blood Glucose / Q000378:metabolism; D003071:Cognition / Q000502:physiology*; D004032:Diet / Q000009:adverse effects*; D018149:Glucose Intolerance; D005951:Glucose Tolerance Test; D007202:Indicators and Reagents; D007333:Insulin Resistance / Q000502:physiology*; D008055:Lipids / Q000097:blood; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D011597:Psychomotor Performance / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D015430:Weight Gain
chemical_list: D001786:Blood Glucose; D007202:Indicators and Reagents; D008055:Lipids