title: Iron absorption and iron status are reduced after Roux-en-Y gastric bypass.
abstract: BACKGROUND
  Iron deficiency and iron deficiency anemia are common in patients who undergo gastric bypass. The magnitude of change in iron absorption is not well known.
  
  
  OBJECTIVE
  The objective was to evaluate the effects of Roux-en-Y gastric bypass (RYGBP) on iron status and iron absorption at different stages after surgery. We hypothesized that iron absorption would be markedly impaired immediately after surgery and would not improve after such a procedure.
  
  
  METHODS
  Anthropometric, body-composition, dietary, hematologic, and iron-absorption measures were determined in 67 severe and morbidly obese women [mean age: 36.9 +/- 9.8 y; weight: 115.1 +/- 15.6 kg, body mass index (BMI: in kg/m(2)); 45.2 +/- 4.7] who underwent RYGBP. The Roux-en-Y loop length was 125-150 cm. Determinations were carried out before and 6, 12, and 18 mo after surgery. Fifty-one individuals completed all 4 evaluations.
  
  
  RESULTS
  The hemoglobin concentration decreased significantly throughout the study (repeated-measures analysis of variance). The percentage of anemic subjects changed from 1.5% at the beginning of the study to 38.8% at 18 mo. The proportion of patients with low serum ferritin increased from 7.5% to 37.3%. The prevalence of iron deficiency anemia was 23.9% at the end of the experimental period. Iron absorption from both a standard diet and from a standard dose of ferrous ascorbate decreased significantly after 6 mo of RYGBP to 32.7% and 40.3% of their initial values, respectively. No further significant modifications were noted.
  
  
  CONCLUSIONS
  Iron absorption is markedly reduced after RYGBP with no further modifications, at least until 18 mo after surgery.
authors.affiliation: Department of Nutrition, University of Chile, Santiago, Chile. mruz@med.uchile.cl
authors.forename: Manuel
authors.initials: M
authors.lastname: Ruz
authors.forename: Fernando
authors.initials: F
authors.lastname: Carrasco
authors.forename: Pamela
authors.initials: P
authors.lastname: Rojas
authors.forename: Juana
authors.initials: J
authors.lastname: Codoceo
authors.forename: Jorge
authors.initials: J
authors.lastname: Inostroza
authors.forename: Annabella
authors.initials: A
authors.lastname: Rebolledo
authors.forename: Karen
authors.initials: K
authors.lastname: Basfi-fer
authors.forename: Attila
authors.initials: A
authors.lastname: Csendes
authors.forename: Karin
authors.initials: K
authors.lastname: Papapietro
authors.forename: Fernando
authors.initials: F
authors.lastname: Pizarro
authors.forename: Manuel
authors.initials: M
authors.lastname: Olivares
authors.forename: Lei
authors.initials: L
authors.lastname: Sian
authors.forename: Jamie L
authors.initials: JL
authors.lastname: Westcott
authors.forename: K Michael
authors.initials: KM
authors.lastname: Hambidge
authors.forename: Nancy F
authors.initials: NF
authors.lastname: Krebs
mesh_terms: D000293:Adolescent; D000328:Adult; D000713:Anastomosis, Roux-en-Y; D018798:Anemia, Iron-Deficiency / Q000453:epidemiology / Q000378:metabolism*; D001205:Ascorbic Acid / Q000378:metabolism; D004032:Diet; D005260:Female; D005293:Ferritins / Q000097:blood; D015390:Gastric Bypass / Q000379:methods; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D007408:Intestinal Absorption; D007501:Iron / Q000378:metabolism*; D019266:Iron, Dietary / Q000378:metabolism*; D009767:Obesity, Morbid / Q000378:metabolism* / Q000601:surgery; D011183:Postoperative Complications / Q000378:metabolism*; D015995:Prevalence; D055815:Young Adult
chemical_list: D006454:Hemoglobins; D019266:Iron, Dietary; D005293:Ferritins; D007501:Iron; D001205:Ascorbic Acid