title: [Breast cancer: nomograms to predict pathologic response after preoperative chemotherapy].
abstract: If the benefit of adjuvant chemotherapy may be determined at the level of a population, to determine the real chemosensitivity of a tumor at the individual level is impossible. The concept of neoadjuvant chemotherapy in patients with localized breast cancer is interesting because it helps to know the chemosensitivity of a tumor "in vivo". It is possible to use a single criterion to predict the effectiveness of targeted therapies. The chemotherapy is not a targeted therapy, and to determine a biological predictive marker of the response has been impossible so far. The development of mathematical models and use of molecular biology may help to predict chemosensitivity. Initial results are promising. The validation of published works is necessary, but applications are numerous.
authors.affiliation: APHP, Hôpital Tenon, Département de Gynécologie-Obstétrique et Médecine de la Reproduction & UPRES 4053, Université Pierre & Marie Curie (Paris VI), Paris. roman.rouzier@tnn.aphp.fr
authors.forename: Roman
authors.initials: R
authors.lastname: Rouzier
authors.forename: Charles
authors.initials: C
authors.lastname: Coutant
authors.forename: Roberto
authors.initials: R
authors.lastname: Incitti
authors.forename: René
authors.initials: R
authors.lastname: Natowicz
authors.forename: Georges
authors.initials: G
authors.lastname: Chahine
authors.forename: Serge
authors.initials: S
authors.lastname: Uzan
authors.forename: David
authors.initials: D
authors.lastname: Atallah
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy*; D017024:Chemotherapy, Adjuvant; D005260:Female; D006801:Humans
chemical_list: D000970:Antineoplastic Agents