Hemangioblastic characteristics of human adipose tissue-derived adult stem cells in vivo.
Recent studies have demonstrated the existence of a population of adipose tissue-derived adult stem (ADAS) cells that can undergo multilineage differentiation in vitro. However, it remains unclear whether these cells maintain their multilineage potential in vivo. The aim of this study was to investigate whether Flk1(+)CD31(-)CD34(-) ADAS cells have characteristics of hemangioblasts. These human ADAS (hADAS) cells were able to differentiate into endothelial and hematopoietic cells at the single-cell level in vivo. These postnatal Flk1(+)CD31(-)CD34(-) hADAS cells bear characteristics of hemangioblast and may have potential application for the hematopoietic and vascular diseases.
Fang
Baijun
B
Center of Excellence in Tissue Engineering, Henan Institute of Haematology, Henan Tumor Hospital, Zhengzhou University, Zhengzhou, China.
Luo
Suxia
S
Song
Yongping
Y
Li
Ning
N
Cao
Ying
Y
D000273:Adipose Tissue / Q000502:physiology*; D000328:Adult; D053687:Adult Stem Cells / Q000166:cytology / Q000502:physiology*; D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D055018:Hemangioblasts / Q000166:cytology / Q000502:physiology*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008297:Male; D051379:Mice; D016513:Mice, SCID; D018919:Neovascularization, Physiologic