title: Oleanane-type triterpenoids from Aceriphyllum rossii and their cytotoxic activity.
abstract: The hexane-soluble fraction of the roots of Aceriphyllum rossii was used to isolate seven new oleanane-type triterpenoids, aceriphyllic acids C-I (1-7), together with seven known triterpenoids. The structures of aceriphyllic acids C-I were determined as 3alpha-hydroxyolean-12-en-23,29-dioic acid (1), 3beta-hydroxyolean-12-en-23,29-dioic acid (2), 3beta,23-dihydroxyolean-12-en-29-oic acid (3), 3alpha-O-acetylolean-12-en-23,27-dioic acid (4), 3alpha-O-caffeoylolean-12-en-27-oic acid (5), 3alpha-O-acetylolean-12-en-23,29-dioic acid (6), and 3alpha-hydroxyolean-12-en-23-al-27-oic acid (7) by spectroscopic analyses. In the evaluation of the in vitro cytotoxicity of these compounds against the MCF-7 and LLC cancer cell lines, compounds 10 and 13 exhibited cytotoxic activity against the LLC cancer cell line with IC(50) values of 7.63 and 6.56 microM, respectively.
authors.affiliation: College of Pharmacy, Catholic University of Daegu, Gyeongsan 712-702, Korea.
authors.forename: Le Thi Kim
authors.initials: le TK
authors.lastname: Van
authors.forename: Tran Manh
authors.initials: TM
authors.lastname: Hung
authors.forename: Phuong Thien
authors.initials: PT
authors.lastname: Thuong
authors.forename: Tran Minh
authors.initials: TM
authors.lastname: Ngoc
authors.forename: Jin Cheol
authors.initials: JC
authors.lastname: Kim
authors.forename: Han-Su
authors.initials: HS
authors.lastname: Jang
authors.forename: Xing Fu
authors.initials: XF
authors.lastname: Cai
authors.forename: Sei Ryang
authors.initials: SR
authors.lastname: Oh
authors.forename: Byung-Sun
authors.initials: BS
authors.lastname: Min
authors.forename: Mi Hee
authors.initials: MH
authors.lastname: Woo
authors.forename: Jae Sue
authors.initials: JS
authors.lastname: Choi
authors.forename: Hyeong Kyu
authors.initials: HK
authors.lastname: Lee
authors.forename: Kihwan
authors.initials: K
authors.lastname: Bea
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007723:Korea; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009828:Oleanolic Acid / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D031995:Saxifragaceae / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D009828:Oleanolic Acid