Nitrosative and oxidative stress responses in fungal pathogenicity.
Fungal pathogenicity has arisen in polyphyletic manner during evolution, yielding fungal pathogens with diverse infection strategies and with differing degrees of evolutionary adaptation to their human host. Not surprisingly, these fungal pathogens display differing degrees of resistance to the reactive oxygen and nitrogen species used by human cells to counteract infection. Furthermore, whilst evolutionarily conserved regulators, such as Hog1, are central to such stress responses in many fungal pathogens, species-specific differences in their roles and regulation abound. In contrast, there is a high degree of commonality in the cellular responses to reactive oxygen and nitrogen species evoked in evolutionarily divergent fungal pathogens.
Brown
Alistair J P
AJ
School of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, UK. al.brown@abdn.ac.uk
Haynes
Ken
K
Quinn
Janet
J
D000935:Antifungal Agents / Q000494:pharmacology; D005658:Fungi / Q000472:pathogenicity / Q000502:physiology*; D054884:Host-Pathogen Interactions; D006801:Humans; D008954:Models, Biological; D009603:Nitroso Compounds / Q000494:pharmacology; D016877:Oxidants / Q000494:pharmacology; D018384:Oxidative Stress; D013312:Stress, Physiological
D000935:Antifungal Agents; D009603:Nitroso Compounds; D016877:Oxidants