[Relationship between inflammation and neointimal proliferation after coronary stent implantation in porcine model].
OBJECTIVE
To study the relationship between inflammation and neointimal proliferation after coronary stent implantation in porcine model.


METHODS
Twenty normal minipigs were randomly divided into group A (implanted with 316L bare metal stents), group B (implanted with 605L bare metal stents), group C (implanted with PLGA coating 605L stents), and group D (implanted with rapamycin-loaded PLGA coating 605L stents). Each minipig was implanted with two same stents in left anterior descending artery and right coronary artery. Four weeks later, the animals were sacrificed and histomorphometric measurements on the stent-segment coronary arteries were made to calculate the correlation between inflammation area and neointimal area.


RESULTS
Group D had the smallest neointimal area [(0.64 +/- 0.38) mm2, P < 0. 001] and inflammation area (median 0.00 mm2, P = 0.009) among all the groups, while there were no statistical differences among group A, B, and C in neointimal area [(2.09 +/- 0.90), (2.11 +/- 1.07), and (1.42 +/- 0.35) mm2 respectively] and in inflammation area (0.22 , 0.21, and 0.09 mm2, respectively). Bivariate correlation analysis showed that the inflammation area was positively correlated with the neointimal area (P < 0.001, correlation coefficient = 0.719). When stent type, mean injury score, and EEL area were adjusted, partial correlations analysis showed that the inflammation area was still positively correlated with the neointimal area (P = 0.01, correlation coefficient = 0.498).


CONCLUSIONS
Inflammation promotes the neointimal proliferation after coronary stent implantation. Sirolimus-eluting stent may reduce the inflammatory response.
Luo
Tong
T
Department of Cardiology, Fuwai Hospital, CAMS and PUMC, Beijing 100037, China.
Gao
Run-Lin
RL
Ruan
Ying-Mao
YM
Qiu
Hong
H
Chu
Yan
Y
Xu
Xin-Lin
XL
Yuan
Wei-Min
WM
Tian
Yi
Y
Qian
Xin
X
Chen
Xue-Sheng
XS
Zhou
Yan-Wen
YW
Meng
Liang
L
D000818:Animals; D003331:Coronary Vessels / Q000473:pathology*; D054855:Drug-Eluting Stents / Q000009:adverse effects; D007249:Inflammation / Q000473:pathology*; D058426:Neointima / Q000473:pathology*; D015607:Stents / Q000009:adverse effects*; D013552:Swine; D013556:Swine, Miniature; D017539:Tunica Intima / Q000473:pathology