title: Neuropsychological consequences of HIV and substance abuse: a literature review and implications for treatment and future research.
abstract: Neuropsychological dysfunction, ranging from mild cognitive symptoms to dementia has been a consistent part of the clinical picture of HIV/AIDS. However, advances in clinical management, particularly antiretroviral (ARV) treatment, have mitigated the neuropsychological effects of HIV and revised the pattern and nature of cognitive deficits, which are observed in HIV-infected individuals. The attendant improvements in mortality and morbidity have led to a need for programs and interventions that sustain healthy behavior and prevent a resurgence of HIV transmission risk. Psychiatric risk factors, particularly substance use, which often contribute to initial acquisition of HIV, still require attention. These risk factors may also exacerbate neuropsychological dysfunction and compromise adherence to prevention recommendations and treatment. Specifically, a more complete understanding of the effects of substance abuse on the progression of HIV related cognitive decline can inform evaluation and management of HIV seropositives with concurrent substance use disorders. This review provides an overview of the neuropsychology of HIV and substance abuse and the extant research that has examined the effects of both HIV disease and substance use on neuropsychological functioning and implications for treatment and future research.
authors.affiliation: AIDS Research Program, Ponce School of Medicine, Ponce, PR 00732. lnorman@psm.edu
authors.forename: Lisa R
authors.initials: LR
authors.lastname: Norman
authors.forename: Michael
authors.initials: M
authors.lastname: Basso
authors.forename: Anil
authors.initials: A
authors.lastname: Kumar
authors.forename: Robert
authors.initials: R
authors.lastname: Malow
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use; D035843:Biomedical Research; D003072:Cognition Disorders / Q000188:drug therapy / Q000209:etiology / Q000523:psychology*; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy / Q000523:psychology*; D015497:HIV-1; D006801:Humans; D001523:Mental Disorders / Q000150:complications / Q000188:drug therapy; D010349:Patient Compliance / Q000523:psychology; D019966:Substance-Related Disorders / Q000150:complications / Q000188:drug therapy / Q000523:psychology*
chemical_list: D019380:Anti-HIV Agents