[Effects of various neuromediators and regulatory peptides on the impulse activity of neurons in the lateral vestibular nucleus].
The myoelectrode technique and microiontophoresis of physiologically active substances were applied to cats immobilized with neuromuscular relaxant to show that the classic neuromediators (acetylcholine, norepinephrine, GABA etc.) and regulatory peptides (enkephalins, TRHs, vasoactive intestinal peptide (VIP), somatostatin (SS) and others) can influence directly most neurons (58 to 100%) in the lateral vestibular nucleus (LVN). Enkephalins, VIP and SS retained largely their inhibitory effect on the neuron impulse activity in the presence of L-glutamate. Also, enkephalins, VIP and SS are able to stimulate or suppress the inhibitory effect of GABA and glycine. Consequently, the substances under study may act as LVN neuromediators and/or neuromodulators.
Iasnetsov
V V
VV
Pravdivtsev
V A
VA
Motin
V G
VG
Karsanova
S K
SK
Ivanov
Iu V
IuV
D000109:Acetylcholine / Q000494:pharmacology*; D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000818:Animals; D002415:Cats; D007478:Iontophoresis; D008297:Male; D008839:Microelectrodes; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D008771:Nordefrin / Q000494:pharmacology*; D014660:Vasoactive Intestinal Peptide / Q000494:pharmacology*; D003689:Vestibular Nucleus, Lateral / Q000187:drug effects / Q000502:physiology*; D018474:Weightlessness Simulation
D014660:Vasoactive Intestinal Peptide; D000109:Acetylcholine; D008771:Nordefrin