title: Epidemiology of bone tumours in children and young adults.
abstract: Although the epidemiology of malignant bone tumours in children and young adults has been explored, no definitive causation of any specific tumour has yet been identified. We performed a literature review (1970-2008) to find all papers covering possible aetiological factors involved in the development of bone tumours in children and young adults. Several associations have been reported with some consistency: the presence of hernias and Ewing sarcoma; high fluoride exposure and osteosarcoma; and parental farming and residence on a farm, younger age at puberty and family history of cancer for all bone tumours, especially osteosarcoma. Clearly further research is needed to confirm or refute these putative risk factors. It is likely that studies of gene-environment interactions may prove to be the most fruitful of future research.
authors.affiliation: Institute of Health and Society, Newcastle University, Newcastle upon Tyne, England, United Kingdom.
authors.forename: Rachel
authors.initials: R
authors.lastname: Eyre
authors.forename: Richard G
authors.initials: RG
authors.lastname: Feltbower
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Mubwandarikwa
authors.forename: Tim O B
authors.initials: TO
authors.lastname: Eden
authors.forename: Richard J Q
authors.initials: RJ
authors.lastname: McNally
mesh_terms: D001859:Bone Neoplasms / Q000191:economics / Q000453:epidemiology*; D002648:Child; D006801:Humans; D007348:Insurance, Health / Q000639:trends; D017741:Survivors; D055815:Young Adult