Role of Wnt inhibitory factor-1 and Wnt/wingless signaling in choroid plexus tumors.
Little is known on pathways involved in the pathogenesis of choroid plexus tumors (CPTs). The finding of overexpression of Wnt inhibitory factor-1 (Wif-1) prompted us to investigate the functional role of Wif-1 as well as nuclear accumulation of beta-catenin in CPT. In Z310 neoplastic choroid plexus epithelial cells, silencing of Wif1 expression increased proliferative activity not associated with increased canonical Wnt signaling. Nuclear beta-catenin accumulation was also lacking in a series of 16 CPT. In conclusion, our data show that Wif-1 inhibits proliferation of neoplastic choroid plexus epithelial cells, but argue against a role of canonical Wnt/wingless signaling in CPT.
Tomm
Manuel
M
Institute of Neuropathology, University Hospital Münster, Münster, Germany.
Koch
Arend
A
Mertsch
Sonja
S
Wrede
Brigitte
B
Jeibmann
Astrid
A
Wolff
Johannes
J
Paulus
Werner
W
Hasselblatt
Martin
M
D048868:Adaptor Proteins, Signal Transducing / Q000502:physiology*; D000818:Animals; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D016545:Choroid Plexus Neoplasms / Q000473:pathology*; D004847:Epithelial Cells / Q000473:pathology; D051381:Rats; D012097:Repressor Proteins / Q000502:physiology*; D015398:Signal Transduction; D051153:Wnt Proteins / Q000502:physiology*
D048868:Adaptor Proteins, Signal Transducing; D012097:Repressor Proteins; C485569:WIF1 protein, human; D051153:Wnt Proteins