Cardiac reanimation: targeting cardiomyocyte death by BNIP3 and NIX/BNIP3L.
Programmed cardiac myocyte death contributes to pathological ventricular remodeling and the progression of myocardial infarction or pressure overload hypertrophy to dilated cardiomyopathy. Recent work has identified importance of stress-mediated transcriptional induction of BNIP3 (BCL2 and 19-kDa interacting protein-3) and NIX/BNIP3L in cardiac remodeling. Here, the regulatory mechanisms for these two factors in the heart and their effects on programmed cardiomyocyte death are reviewed, with a focus on information derived from studies using mouse models of cardiac BNIP3 and NIX/BNIP3L overexpression and gene ablation.
Dorn
G W
GW
Department of Medicine, Center for Pharmacogenomics, Washington University School of Medicine, St Louis, MO 63110, USA.
Kirshenbaum
L A
LA
D000818:Animals; D002311:Cardiomyopathy, Dilated / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D016923:Cell Death / Q000187:drug effects / Q000502:physiology; D018450:Disease Progression; D016503:Drug Delivery Systems; D005786:Gene Expression Regulation; D006333:Heart Failure / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D006801:Humans; D008565:Membrane Proteins / Q000037:antagonists & inhibitors* / Q000502:physiology; D051379:Mice; D008822:Mice, Transgenic; D024101:Mitochondrial Proteins / Q000037:antagonists & inhibitors* / Q000502:physiology; D009203:Myocardial Infarction / Q000150:complications / Q000473:pathology / Q000503:physiopathology; D032383:Myocytes, Cardiac / Q000187:drug effects*; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D011518:Proto-Oncogene Proteins / Q000502:physiology; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000502:physiology; D013314:Stress, Mechanical; D014158:Transcription, Genetic; D025521:Tumor Suppressor Proteins / Q000502:physiology; D020257:Ventricular Remodeling / Q000187:drug effects*
C090121:BNIP3 protein, human; C116838:BNIP3L protein, human; C508686:BNip3 protein, mouse; D008565:Membrane Proteins; D024101:Mitochondrial Proteins; C501741:Nix protein, mouse; D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D025521:Tumor Suppressor Proteins