A case of melanotic desmoplastic ganglioglioma.
We describe a case of desmoplastic infantile ganglioglioma (DIG) in a 9-month-old boy located in the temporal lobe. Grossly the tumor was brown and superficially located. Histologically the tumor contained pigment in numerous neoplastic cells, shown to be melanosomal melanin by ultrastructural examination. Pigmented neoplasms have been reported at various sites in the central and peripheral nervous system. Previous reports on pigmented neuroepithelial tumors include neoplasms containing melanin, while others have contained neuromelanin and or lipofuscin. This case represents the first description of pigmented neoplastic cells in DIG, enlarging the spectrum of pigmented primary CNS tumors.
Antonelli
Manila
M
Departement of Pathology, University La Sapienza, Rome, Italy. manila_antonelli@yahoo.it
Acerno
Stefania
S
Baldoli
Cristina
C
Terreni
Maria Rosaria
MR
Giangaspero
Felice
F
D001932:Brain Neoplasms / Q000378:metabolism* / Q000473:pathology* / Q000648:ultrastructure; D005500:Follow-Up Studies; D018303:Ganglioglioma / Q000378:metabolism* / Q000473:pathology* / Q000648:ultrastructure; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D008543:Melanins / Q000378:metabolism*; D013702:Temporal Lobe / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure
D008543:Melanins