NMR assignment of PN2-3, a tubulin interaction subdomain of the CPAP protein.
We report the NMR assignment of the PN2-3 subdomain of the CPAP protein. It has been previously shown that this motif interacts with tubulin, inhibits microtubule nucleation from the centrosome and depolymerizes taxol-stabilized microtubules.
Clément
Marie-Jeanne
MJ
Laboratoire Structure-Activité des Biomolécules Normales et Pathologiques, INSERM/UEVE U829-Université Evry-Val d'Essonne, Bâtiment Maupertuis, 91025, Evry, France.
Savarin
Philippe
P
Coutant
Jérôme
J
Toma
Flavio
F
Curmi
Patrick
P
D000595:Amino Acid Sequence; D001665:Binding Sites; D002247:Carbon Isotopes / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008869:Microtubule-Associated Proteins / Q000737:chemistry*; D008969:Molecular Sequence Data; D008970:Molecular Weight; D009587:Nitrogen Isotopes / Q000737:chemistry; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D011522:Protons; D014404:Tubulin / Q000737:chemistry*
C414735:CENPJ protein, human; D002247:Carbon Isotopes; D008869:Microtubule-Associated Proteins; D009587:Nitrogen Isotopes; D011522:Protons; D014404:Tubulin