title: The MMP2 gene may be associated with longissimus dorsi muscle area in the pig (Sus scrofa).
abstract: The matrix metalloproteinase-2 gene (MMP2) was found to be associated with hip structure in pigs. Recently three quantitative trait loci (QTLs) for loin muscle area were found on chromosome 6, to which MMP2 was mapped. In the present study, association analyses were conducted in two pig populations for a single-nucleotide polymorphism (SNP) c.-1959C>G present at a putative promoter region of the MMP2 gene. The association results showed that the animals with the C allele have a significantly larger loin muscle area than that of the animals with the G allele (P < 0.05). To confirm the present results, further functional studies and an additional causative SNP discovery in pigs with various genetic backgrounds are necessary.
authors.affiliation: Department of Animal Science and Center for Integrated Animal Genomics, 2262, Kildee Hall, Iowa State University, Ames, IA 50011, USA. sonteru@iastate.edu
authors.forename: S K
authors.initials: SK
authors.lastname: Onteru
authors.forename: B
authors.initials: B
authors.lastname: Fan
authors.forename: M F
authors.initials: MF
authors.lastname: Rothschild
mesh_terms: D000818:Animals; D005787:Gene Frequency / Q000235:genetics; D020778:Matrix Metalloproteinase 2 / Q000235:genetics*; D018482:Muscle, Skeletal / Q000033:anatomy & histology* / Q000201:enzymology; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D040641:Quantitative Trait Loci; D034421:Sus scrofa / Q000033:anatomy & histology* / Q000235:genetics*
chemical_list: D020778:Matrix Metalloproteinase 2