Synthesis of tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate.
Two efficient and scaleable synthetic routes to previously unknown bifunctional tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate are described. This compound and related intermediates described herein are useful for further selective derivation on the azetidine and cyclobutane rings providing a convenient entry point to novel compounds accessing chemical space complementary to piperidine ring systems.
Meyers
Marvin J
MJ
Pfizer Global Research & Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017, USA. marVin.j.meyers@pfizer.com
Muizebelt
Inouk
I
van Wiltenburg
Jim
J
Brown
David L
DL
Thorarensen
Atli
A
D001372:Aza Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D010880:Piperidines / Q000737:chemistry*; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism
D001372:Aza Compounds; D010880:Piperidines; D013141:Spiro Compounds; C544253:tert-butyl 6-oxo-2-azaspiro(3.3)heptane-2-carboxylate; C032727:piperidine