Regulatory T cells in atopic dermatitis.
Atopic dermatitis is one of the most prevalent chronic eczematous inflammatory skin diseases in westernized populations. It is caused by both skin barrier dysfunction and abnormal immunologic response. An imbalance of effector T cells and regulatory T cells is a crucial factor in the initiation of allergic diseases. Recent advances in immunology have revealed the role of regulatory T cells in atopic dermatitis. Treatment of atopic dermatitis consists of restoring and maintaining a sufficient skin barrier and inducing a balanced systemic immune response.
Oiso
Naoki
N
Department of Dermatology, Kinki University Faculty of Medicine, 377-2 Ohno-Higashi, Osaka-Sayama, Osaka 589-8511, Japan. naoiso@med.kindai.ac.jp
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D003876:Dermatitis, Atopic / Q000188:drug therapy* / Q000276:immunology; D006706:Homeostasis; D008213:Lymphocyte Activation; D012867:Skin / Q000187:drug effects / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D058408:Th1-Th2 Balance
D000893:Anti-Inflammatory Agents