title: Synthesis and evaluation of 4-acyl-2-thiazolylhydrazone derivatives for anti-Toxoplasma efficacy in vitro.
abstract: A new series of 4-acyl-2-thiazolylhydrazone derivatives was synthesized and screened for its in vitro activity against Toxoplasma gondii. We evaluated parasite growth inhibition and cytotoxicity, inhibition of replication, and inhibition of parasite invasion of host cells. The biological results indicated that some substances had an antiproliferative effect against intracellular T. gondii tachyzoites cultivated in vitro.
authors.affiliation: Dipartimento di Chimica e Tecnologie del Farmaco, Università La Sapienza, P.le A. Moro 5, 00185 Rome, Italy.
authors.forename: Franco
authors.initials: F
authors.lastname: Chimenti
authors.forename: Bruna
authors.initials: B
authors.lastname: Bizzarri
authors.forename: Adriana
authors.initials: A
authors.lastname: Bolasco
authors.forename: Daniela
authors.initials: D
authors.lastname: Secci
authors.forename: Paola
authors.initials: P
authors.lastname: Chimenti
authors.forename: Simone
authors.initials: S
authors.lastname: Carradori
authors.forename: Arianna
authors.initials: A
authors.lastname: Granese
authors.forename: Daniela
authors.initials: D
authors.lastname: Rivanera
authors.forename: Nathan
authors.initials: N
authors.lastname: Frishberg
authors.forename: Claudia
authors.initials: C
authors.lastname: Bordón
authors.forename: Lorraine
authors.initials: L
authors.lastname: Jones-Brando
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D006835:Hydrazones / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014122:Toxoplasma / Q000187:drug effects* / Q000254:growth & development
chemical_list: D000981:Antiprotozoal Agents; D006835:Hydrazones