title: [Cardiovascular assessment of non diabetic patients on hemodialysis].
abstract: BACKGROUND
  Diabetes mellitus is an important risk factor for cardiovascular complications among patients on hemodialysis. However, the incidence of these complications among non diabetic patients on hemodialysis is not well known.
  
  
  OBJECTIVE
  To assess the incidence of cardiovascular complications in non diabetic patients on hemodialysis.
  
  
  METHODS
  Seventy five non diabetic patients aged 55.6 +/- 17 years (48 males), receiving hemodialysis three times a week were evaluated with laboratory tests, echocardiogram anda carotid ultrasound. In 26 patients, interleukin 6, tumor necrosis factor alpha, and intercellular adhesión molecule (ICAM-1) were also measured. Patients were followed during two years.
  
  
  RESULTS
  The mean lapse of dialysis therapy was 6.5 +/-5 years. The main cause of renal failure was hypertension. Sixty two percent had systolic hypertension, 86% had concentric left ventricular hypertrophy, 43% had atrial dilatation and 60% had calcifications in the thoracic aorta. Compared with normal controls, patients had higher levels of interleukin 6, tumor necrosis factor alpha and ICAM-1. Carotid media thickness was also higher and increased in the two years of follow up. No correlations were found between ventricular hypertrophy and dialysis lapse, packed red cell volume, calcium phosphorus product, parathormone levels or median arterial pressure. No cardiovascular events were recorded during the follow up period.
  
  
  CONCLUSIONS
  Non diabetic patients on chronic hemodialysis have a high frequency of ventricular hypertrophy, carotid media thickening, aortic calcifications and an increase in proinflammatory cytokines.
authors.affiliation: Facultad de Medicina, Universidad de los Andes, Santiago, Chile. skunstmann@clc.cl
authors.forename: Sonia
authors.initials: S
authors.lastname: Kunstmann
authors.forename: Antonio
authors.initials: A
authors.lastname: Vukusich
authors.forename: Luis
authors.initials: L
authors.lastname: Michea
authors.forename: Cristian
authors.initials: C
authors.lastname: Varela
authors.forename: Irene
authors.initials: I
authors.lastname: Allende
authors.forename: Sebastián
authors.initials: S
authors.lastname: Bravo
authors.forename: Daniela
authors.initials: D
authors.lastname: Gainza
authors.forename: Daniela
authors.initials: D
authors.lastname: Sepúlveda
authors.forename: Elisa
authors.initials: E
authors.lastname: Marusic
authors.forename: Fernando
authors.initials: F
authors.lastname: Figueroa
mesh_terms: D001794:Blood Pressure / Q000502:physiology; D002318:Cardiovascular Diseases / Q000097:blood / Q000209:etiology*; D016022:Case-Control Studies; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D007375:Interleukin-1 / Q000097:blood; D007676:Kidney Failure, Chronic / Q000097:blood / Q000150:complications* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis / Q000009:adverse effects*; D012307:Risk Factors; D017678:Sex Distribution
chemical_list: D016207:Cytokines; D018836:Inflammation Mediators; D007375:Interleukin-1