title: Synthesis and combinational antibacterial study of 5''-modified neomycin.
abstract: A library of 5''-modified neomycin derivatives were synthesized for an antibacterial structure-activity optimization strategy. Two leads exhibited prominent activity against both methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE). Antibacterial activities were measured when combined with other clinically used antibiotics. Significant synergistic activities were observed, which may lead to the development of novel therapeutic practices in the battle against infectious bacteria.
authors.affiliation: Department of Chemistry and Biochemistry, Utah State University, Logan, UT 84322-0300, USA.
authors.forename: Jianjun
authors.initials: J
authors.lastname: Zhang
authors.forename: Katherine
authors.initials: K
authors.lastname: Keller
authors.forename: Jon Y
authors.initials: JY
authors.lastname: Takemoto
authors.forename: Mekki
authors.initials: M
authors.lastname: Bensaci
authors.forename: Anthony
authors.initials: A
authors.lastname: Litke
authors.forename: Przemyslaw Greg
authors.initials: PG
authors.lastname: Czyryca
authors.forename: Cheng-Wei Tom
authors.initials: CW
authors.lastname: Chang
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D016983:Enterococcus / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D006801:Humans; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D009355:Neomycin / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D020713:Vancomycin Resistance
chemical_list: D000900:Anti-Bacterial Agents; D009355:Neomycin