Potential of a unique antibody gene signature to predict conversion to clinically definite multiple sclerosis.
We identified a unique antibody gene mutation pattern (i.e. "signature") in cerebrospinal fluid (CSF) B cells from multiple sclerosis (MS) patients not present in control populations. Prevalence of the signature in CSF B cells of patients at risk to develop MS predicted conversion to MS with 91% accuracy in a small cohort of clinically isolated syndrome patients. If confirmed, signature prevalence would be a novel genetic diagnostic tool candidate for patients with early demyelinating disease of the central nervous system.
Cameron
Elizabeth M
EM
Department of Neurology, University of Texas Southwestern Medical Center, Dallas TX 75154, USA.
Spencer
Sade
S
Lazarini
Jonathan
J
Harp
Christopher T
CT
Ward
E Sally
ES
Burgoon
Mark
M
Owens
Gregory P
GP
Racke
Michael K
MK
Bennett
Jeffrey L
JL
Frohman
Elliot M
EM
Monson
Nancy L
NL
D000595:Amino Acid Sequence / Q000235:genetics; D000906:Antibodies / Q000032:analysis / Q000134:cerebrospinal fluid / Q000235:genetics*; D001323:Autoantibodies / Q000032:analysis / Q000134:cerebrospinal fluid / Q000235:genetics; D001402:B-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D015415:Biomarkers / Q000032:analysis / Q000134:cerebrospinal fluid; D030541:Databases, Genetic; D003943:Diagnostic Techniques, Neurological; D018450:Disease Progression; D005796:Genes / Q000235:genetics*; D005819:Genetic Markers / Q000235:genetics / Q000276:immunology; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis / Q000134:cerebrospinal fluid / Q000235:genetics; D008967:Molecular Biology / Q000379:methods; D009103:Multiple Sclerosis / Q000175:diagnosis / Q000235:genetics* / Q000276:immunology*; D009154:Mutation / Q000235:genetics*; D020543:Proteome; D016415:Sequence Alignment
D000906:Antibodies; D001323:Autoantibodies; D015415:Biomarkers; D005819:Genetic Markers; D007136:Immunoglobulins; D020543:Proteome