Ipsilateral breast tumor relapse after breast conserving surgery in women with breast cancer.
Ipsilateral breast tumor relapse (IBTR) is a potentially a significant problem after breast conserving surgery (BCS). With a median follow-up period of 64.7 months, IBTR occurred as a first relapse in 67 (3.0%) of a total of 2243 patients and distant recurrence occurred in 167 (7.4%). A positive surgical margin and the omission of radiotherapy (RT) were independently associated with IBTR. The five-year cumulative IBTR rates were 5.1% in patients with positive margins and 2.0% in the patients with negative margins. The five-year cumulative IBTR rates were 1.8% in patients with RT and 8.1% in patients without RT. IBTR was independently associated with distant-recurrence-free survival rates as well as age, nodal metastasis, lymphovascular invasion and progesterone receptor status. The five-year distant-recurrence-free survival rates were 81.9% in patients with IBTR and 93.2% in patients without IBTR. In order to prevent IBTR, a negative margin and the administration of RT are therefore considered to be important in patients who undergo BCS.
Yoshida
Takashi
T
Division of Breast Surgery, Saitama Cancer Center, 818 Komuro, Ina, Kita-Adachi, Saitama 362-0806, Japan. ytakashi@cancer-c.pref.saitama.jp
Takei
Hiroyuki
H
Kurosumi
Masafumi
M
Ninomiya
Jun
J
Ishikawa
Yuko
Y
Hayashi
Yuji
Y
Tozuka
Katsunori
K
Oba
Hanako
H
Inoue
Kenichi
K
Tabei
Toshio
T
D000328:Adult; D001943:Breast Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D015412:Mastectomy, Segmental; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology*; D018714:Radiotherapy, Adjuvant; D012307:Risk Factors