title: [Surveillance for occult HBV infection and HBsAg variants in blood donors].
abstract: Occult hepatitis B virus (HBV) infection status of blood donors in a southern city in China was investigated by immunological assays and nucleic acid testing. Overall, 17 (0.19%, 95% CI: 0.11%-0.30%) of the 9023 HBsAg negative samples were found to be positive for the presence of HBV DNA. "A" epitope sequences were obtained from 14 among them. Mutation(s) in aa124-aa147 existed in 6 (42.9%, 6/14) samples and 4 (66.7%, 4/6)were G145R mutation. Ratio of genotype C in occult donors (10/17) was statistically higher than HBs-positive donors (0/15, P<0.01), which implied that HBV genotype C leaded to occult infection more easily.
authors.affiliation: Xiamen Blood Services, Xiamen 361004, China. zxxz@public.xm.fj.cn
authors.forename: Chang-rong
authors.initials: CR
authors.lastname: Chen
authors.forename: Quan
authors.initials: Q
authors.lastname: Yuan
authors.forename: Sheng-xiang
authors.initials: SX
authors.lastname: Ge
authors.forename: Shan-hai
authors.initials: SH
authors.lastname: Ou
authors.forename: Hong-ying
authors.initials: HY
authors.lastname: Ni
authors.forename: Yong-chang
authors.initials: YC
authors.lastname: Zhang
authors.forename: Bin
authors.initials: B
authors.lastname: Pei
authors.forename: An
authors.initials: A
authors.lastname: Li
authors.forename: Qiang
authors.initials: Q
authors.lastname: Yan
authors.forename: Yong-cai
authors.initials: YC
authors.lastname: Lin
authors.forename: Qing-rui
authors.initials: QR
authors.lastname: Chen
authors.forename: Ning-shao
authors.initials: NS
authors.lastname: Xia
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D001782:Blood Donors; D002681:China / Q000453:epidemiology; D004279:DNA, Viral / Q000235:genetics; D005260:Female; D005838:Genotype; D006509:Hepatitis B / Q000453:epidemiology* / Q000276:immunology / Q000821:virology; D006514:Hepatitis B Surface Antigens / Q000235:genetics / Q000276:immunology*; D006515:Hepatitis B virus / Q000145:classification / Q000235:genetics / Q000276:immunology / Q000502:physiology*; D006801:Humans; D007159:Immunologic Tests; D008297:Male; D009154:Mutation; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D055815:Young Adult
chemical_list: D004279:DNA, Viral; D006514:Hepatitis B Surface Antigens