[Individualized prevention of type 2 diabetes].
The global estimated prevalence of diabetes today is 246 million people. By 2025, the figure is expected to rise to 380 million. In Germany about 7 to 8% of the population is diagnosed with diabetes. However, there are a large proportion of people with unknown diabetes and the total number of subjects with diabetes is estimated at 7 to 8 million, indicating that every tenth individual is affected by the disease. Several recent studies unanimously revealed that it is possible to prevent type 2 diabetes. Particularly lifestyle intervention showed promising results. However, there is large variability in the effect of the intervention, and people with a good response (responders) and with a low response (non-responders) can be identified. Meanwhile, several genetic and phenotypic markers have been identified, which can help predict the success of the lifestyle intervention, allowing for a more effective individualized prevention of type 2 diabetes.
Stefan
N
N
Heisenberg-Stipendium der Deutschen Forschungsgemeinschaft, Universitätsklinik Tübingen, Otfried-Müller-Str. 10, 72076 Tübingen. norbert.stefan@med.uni-tuebingen.de
Fritsche
A
A
Häring
H-U
HU
D000328:Adult; D050218:Body Fat Distribution; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000235:genetics / Q000517:prevention & control; D003131:Combined Modality Therapy; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000235:genetics* / Q000517:prevention & control*; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005858:Germany; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D008019:Life Style; D008297:Male; D010641:Phenotype; D016896:Treatment Outcome
D005819:Genetic Markers; D007004:Hypoglycemic Agents