title: Amiodarone as a first-line therapy for postoperative junctional ectopic tachycardia.
abstract: BACKGROUND
  Postoperative junctional ectopic tachycardia is a potentially life-threatening arrhythmia that is often resistant to conventional antiarrhythmic drugs. Amiodarone was suggested to be an adequate treatment; however, data regarding its efficacy and safety are limited. This study evaluated the efficacy of amiodarone in the first-line treatment of postoperative junctional ectopic tachycardia and assessed factors associated with failure of amiodarone therapy.
  
  
  METHODS
  The study included 40 pediatric cardiosurgical patients with postoperative junctional ectopic tachycardia. Intravenous amiodarone in 2-mg/kg boluses and, if necessary, as continuous infusion (10 to 15 mug/kg/min), were used as the first-line therapy. Restoration of sinus rhythm or slowing of junctional ectopic tachycardia to a rate that allowed atrial or atrioventricular sequential pacing was considered as efficacy of therapy.
  
  
  RESULTS
  Amiodarone was effective in 18 patients (45%). Sinus rhythm was achieved in 7, and heart rate decreased in 11 patients from 180 (range, 173 to 200) to 142 (range, 133-155) beats/min (p < 0.0001) and allowed effective pacing with atrioventricular synchrony. Higher arteriovenous oxygen saturation difference (p = 0.007) and lower body temperature (p = 0.02) were associated with failure of amiodarone therapy.
  
  
  CONCLUSIONS
  Amiodarone as the first-line treatment was effective in almost half of the patients with postoperative junctional ectopic tachycardia. Higher arteriovenous oxygen saturation difference and lower body temperature were associated with failure of amiodarone therapy, and their presence may suggest more aggressive initial approach consisting of amiodarone combined with hypothermia.
authors.affiliation: Intensive Care Unit, Children's Cardiac Center, Bratislava, Slovakia. lkovacikova@yahoo.com
authors.forename: Lubica
authors.initials: L
authors.lastname: Kovacikova
authors.forename: Nina
authors.initials: N
authors.lastname: Hakacova
authors.forename: Dusan
authors.initials: D
authors.lastname: Dobos
authors.forename: Peter
authors.initials: P
authors.lastname: Skrak
authors.forename: Martin
authors.initials: M
authors.lastname: Zahorec
mesh_terms: D000638:Amiodarone / Q000008:administration & dosage / Q000627:therapeutic use*; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D006348:Cardiac Surgical Procedures; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D006330:Heart Defects, Congenital / Q000601:surgery*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007036:Hypothermia, Induced; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011183:Postoperative Complications / Q000188:drug therapy*; D011446:Prospective Studies; D013613:Tachycardia, Ectopic Junctional / Q000188:drug therapy*
chemical_list: D000889:Anti-Arrhythmia Agents; D000638:Amiodarone