Ankyrin-based patterning of membrane microdomains: new insights into a novel class of cardiovascular diseases.
The organization of membrane-spanning proteins within discrete microdomains is critical for their physiologic function. This is especially important in the heart, where ion transporter and force-transducing microdomains are responsible for excitation-contraction coupling, anisotropic depolarization, and mechanotransduction. The following review will discuss recent advances in our understanding of the patterning of ion channel and force-transmitting membrane microdomains in cardiomyocytes, focusing on the T-tubule and intercalated disc.
Nilsson
Kent R
KR
Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC 27713, USA. kent.nilsson@duke.edu
Bennett
Vann
V
D000818:Animals; D017487:Ankyrins / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000503:physiopathology*; D006801:Humans; D007473:Ion Channels / Q000378:metabolism; D021962:Membrane Microdomains / Q000378:metabolism*; D032383:Myocytes, Cardiac / Q000378:metabolism
D017487:Ankyrins; D007473:Ion Channels