title: [Research of neuronal structures target localization based on Hilbert-Huang transform for neuronal discharges].
abstract: Electrophysiological target localization is the key technology in microelectrode-guided stereotactic neurosurgery for Parkinson's disease (PD). A neuronal discharge signal analysis method based on Hilbert-Huang transform (HHT) was introduced. By decomposing the clinical microelectrode recording (MER) data of PD into intrinsic mode functions (IMFs), the marginal spectrums of IMFs were achieved, and the characteristic factor correlated with brain structure was explored, then the HHT characteristic factor curve of neuronal discharge signals of microelectrode piqure locus could be achieved. The structures of neuronal and boundaries can be distinguished by the characteristic factor curve, and then damage range and damage point can be identified. This method can assist clinicians in ascertaining operation target effectively and researching into the cases of PD.
authors.affiliation: Department of Biomedical Engineering, College of Automation Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, China.
authors.forename: Han
authors.initials: H
authors.lastname: Xue
authors.forename: Zhiyu
authors.initials: Z
authors.lastname: Qian
authors.forename: Tianming
authors.initials: T
authors.lastname: Yang
mesh_terms: D004594:Electrophysiology; D006801:Humans; D008839:Microelectrodes; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D009493:Neurosurgery / Q000379:methods*; D010300:Parkinson Disease / Q000503:physiopathology / Q000601:surgery*; D012815:Signal Processing, Computer-Assisted; D013238:Stereotaxic Techniques