Low plasma potassium in deep hypothermic cardiac arrest indicates that cardiac arrest is secondary to hypothermia: a porcine study.
OBJECTIVE
In accidental hypothermia, normal signs of death are unreliable. It is generally accepted that a lifeless person is beyond the limits of rescue if plasma potassium (P-potassium) is higher than10 mmol/l. However, the rate of increase in potassium or in other markers after cardiac arrest has not been carefully studied in hypothermic individuals. The aim of this animal study was to assess biochemical changes after anoxic circulatory arrest at hypothermia and at normothermia followed by external cooling.


METHODS
Five pigs were treated with heparin and extracorporeal circulation and cooled to 20 degrees C (primary hypothermia group). The animals were weaned from extracorporeal circulation, suffered cardiac arrest, and were cooled externally with ice to mimic victims found in a cold environment. With the use of intermittent external cardiac compressions mixing the blood, arterial P-potassium was followed after cardiac arrest until the level exceeded 10 mmol/l. Another group of five pigs (anoxic cardiac arrest group) were treated with heparin and killed by anoxia at normothermia and were thereafter treated and followed similarly to the primary hypothermia group.


RESULTS
In primary hypothermia P-potassium exceeded 10 mmol/l after median 3.5 h, whereas in anoxic cardiac arrest P-potassium exceeded 10 mmol/l after median 1 h.


CONCLUSIONS
This study shows that if cardiac arrest occurs before hypothermia is established, P-potassium increases quickly in contrast to the situation when hypothermia induces cardiac arrest. Thus, a low P-potassium in a hypothermic individual with cardiac arrest indicates that cardiac arrest occurred recently or was secondary to the hypothermic event.
Kjaergaard
Benedict
B
Center for Cardiovascular Research, Aalborg Hospital, Aalborg, Denmark. benedict@dadlnet.dk
Jakobsen
Louise K
LK
Nielsen
Conny
C
Knudsen
Peter J
PJ
Kristensen
Søren R
SR
Larsson
Anders
A
D018686:Anesthetics, Intravenous; D000818:Animals; D001376:Azaperone; D015415:Biomarkers; D001831:Body Temperature; D050792:Circulatory Arrest, Deep Hypothermia Induced; D006993:Hypnotics and Sedatives; D000860:Hypoxia / Q000150:complications*; D008874:Midazolam; D011188:Potassium / Q000097:blood*; D012307:Risk Factors; D013552:Swine; D013997:Time Factors
D018686:Anesthetics, Intravenous; D015415:Biomarkers; D006993:Hypnotics and Sedatives; D001376:Azaperone; D008874:Midazolam; D011188:Potassium