Chain reactions: early-life stress alters the metabolic profile of plasma polyunsaturated fatty acids in adulthood.
The rat maternal separation paradigm can be used to examine the biological consequences of early-life stress. Immunomodulatory polyunsaturated fatty acids (PUFAs) have recently attracted attention in the study of stress-related disorders. We established the plasma PUFA profile of maternally separated rodents compared to controls. Our results identify a proinflammatory PUFA profile as a persistent consequence of early-life stress and suggest new avenues of investigation in stress-related disorders.
Clarke
Gerard
G
Department of Psychiatry, University College Cork, Cork, Ireland; Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland. g.clarke@ucc.ie
O'Mahony
Siobhain M
SM
Hennessy
Alan A
AA
Ross
Paul
P
Stanton
Catherine
C
Cryan
John F
JF
Dinan
Timothy G
TG
D000375:Aging; D000818:Animals; D016718:Arachidonic Acid / Q000097:blood; D004195:Disease Models, Animal; D015525:Fatty Acids, Omega-3 / Q000097:blood; D043371:Fatty Acids, Omega-6 / Q000097:blood; D005231:Fatty Acids, Unsaturated / Q000097:blood*; D008297:Male; D008426:Maternal Deprivation; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013315:Stress, Psychological / Q000097:blood*; D013997:Time Factors
D015525:Fatty Acids, Omega-3; D043371:Fatty Acids, Omega-6; D005231:Fatty Acids, Unsaturated; D016718:Arachidonic Acid