Model-based evolutionary analysis: the natural history of phage-shock stress response.
The evolution of proteins is inseparably linked to their function. Because most biological processes involve a number of different proteins, it may become impossible to study the evolutionary properties of proteins in isolation. In the present article, we show how simple mechanistic models of biological processes can complement conventional comparative analyses of biological traits. We use the specific example of the phage-shock stress response, which has been well characterized in Escherichia coli, to elucidate patterns of gene sharing and sequence conservation across bacterial species.
Huvet
Maxime
M
Division of Molecular Biosciences, Imperial College London, Centre for Bioinformatics, South Kensington, London SW7 2AZ, UK.
Toni
Tina
T
Tan
Hui
H
Jovanovic
Goran
G
Engl
Christoph
C
Buck
Martin
M
Stumpf
Michael P H
MP
D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D004926:Escherichia coli / Q000378:metabolism; D029968:Escherichia coli Proteins / Q000235:genetics / Q000378:metabolism; D019143:Evolution, Molecular; D006360:Heat-Shock Proteins / Q000235:genetics / Q000378:metabolism; D008962:Models, Theoretical
D001426:Bacterial Proteins; D029968:Escherichia coli Proteins; D006360:Heat-Shock Proteins; C069816:phage shock protein, Bacteria