title: A click chemistry approach for the synthesis of macrocycles from aryl amide-based precursors directed by hydrogen bonding.
abstract: This paper describes the synthesis of four aryl amide-based macrocycles through the 1 + 1 formation of two 1,2,3-triazole units by click chemistry. Two series of aryl amide-based precursors that bear two azide or acetylene units have been prepared. Intramolecular hydrogen bonding has been utilized to induce them to adopt a U-styled conformation, which remarkably promotes the macrocyclization of two structurally matched precursors.
authors.affiliation: State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, 345 Lingling Lu, Shanghai, 200032, China.
authors.forename: Yuan-Yuan
authors.initials: YY
authors.lastname: Zhu
authors.forename: Gui-Tao
authors.initials: GT
authors.lastname: Wang
authors.forename: Zhan-Ting
authors.initials: ZT
authors.lastname: Li
mesh_terms: D000577:Amides / Q000737:chemistry*; D001386:Azides / Q000737:chemistry*; D003500:Cyclization; D006860:Hydrogen Bonding; D015394:Molecular Structure; D055672:Static Electricity
chemical_list: D000577:Amides; D001386:Azides