title: Calorie restriction enhances T-cell-mediated immune response in adult overweight men and women.
abstract: Calorie restriction (CR) enhances immune response and prolongs life span in animals. However, information on the applicability of these results to humans is limited. T-cell function declines with age. We examined effects of CR on T-cell function in humans. Forty-six overweight, nonobese participants aged 20-42 years were randomly assigned to 30% or 10% CR group for 6 months. Delayed-type hypersensitivity (DTH), T-cell proliferation (TP), and prostaglandin E(2) (PGE(2)) productions were determined before and after CR. DTH and TP to T-cell mitogens were increased in both groups over baseline (p < or = .019). However, number of positive responses to DTH antigens (p = .016) and TP to anti-CD3 reached statistical significance only after 30% CR (p = .001). Lipopolysaccharide-stimulated PGE(2) was reduced in both groups but reached statistical significance after 30% CR (p < or = .029). These results, for the first time, show that 6-month CR in humans improves T-cell function.
authors.affiliation: Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA.
authors.forename: Tanvir
authors.initials: T
authors.lastname: Ahmed
authors.forename: Sai Krupa
authors.initials: SK
authors.lastname: Das
authors.forename: Julie K
authors.initials: JK
authors.lastname: Golden
authors.forename: Edward
authors.initials: E
authors.lastname: Saltzman
authors.forename: Susan B
authors.initials: SB
authors.lastname: Roberts
authors.forename: Simin Nikbin
authors.initials: SN
authors.lastname: Meydani
mesh_terms: D000328:Adult; D015992:Body Mass Index; D031204:Caloric Restriction; D015232:Dinoprostone / Q000096:biosynthesis; D005260:Female; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000453:epidemiology; D008213:Lymphocyte Activation; D008297:Male; D050177:Overweight / Q000276:immunology*; D012727:Sex Characteristics; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D015232:Dinoprostone