title: A metal-free general procedure for oxidation of secondary amines to nitrones.
abstract: An efficient and metal-free protocol for direct oxidation of secondary amines to nitrones has been developed, using Oxone in a biphasic basic medium as the sole oxidant. The method is general and tolerant with other functional groups or existing stereogenic centers, providing rapid access to enantiomerically pure compounds in good yields.
authors.affiliation: Universitat Autònoma de Barcelona, Departament de Química, 08193 Bellaterra, Spain.
authors.forename: Carolina
authors.initials: C
authors.lastname: Gella
authors.forename: Eric
authors.initials: E
authors.lastname: Ferrer
authors.forename: Ramon
authors.initials: R
authors.lastname: Alibés
authors.forename: Félíx
authors.initials: F
authors.lastname: Busqué
authors.forename: Pedro
authors.initials: P
authors.lastname: de March
authors.forename: Marta
authors.initials: M
authors.lastname: Figueredo
authors.forename: Josep
authors.initials: J
authors.lastname: Font
mesh_terms: D000588:Amines / Q000737:chemistry*; D009589:Nitrogen Oxides / Q000737:chemistry*; D010084:Oxidation-Reduction; D013237:Stereoisomerism
chemical_list: D000588:Amines; D009589:Nitrogen Oxides; C015388:nitrones