Correlation of antioxidants with lipid peroxidation and lipid profile in patients suffering from coronary artery disease.
In addition to many traditional risk factors for coronary artery disease (CAD) development, enhanced oxidative stress and inflammation are serious conditions that may also be classified as novel risk factors. The objective of the present study was to ascertain the correlation of antioxidants (superoxide dismutase, catalase and vitamin E) with lipid peroxidation (malondialdehyde) and lipid profile (triglycerides and low-density lipoprotein cholesterol (LDL(c))) in patients suffering from coronary artery disease. Lipid profile, malondialdehyde, superoxide dismutase, catalase and vitamin E levels were determined inpatients and controls. Increased levels of Malondialdehyde and decreased levels of antioxidants were observed in patients with coronary artery disease (n = 100) when compared with normal healthy controls (n = 50). A positive correlation of antioxidants was observed with triglycerides and LDL(c). A negative correlation of vitamin E with malondialdehyde and a positive correlation of superoxide dismutase and catalase with malondialdehyde were observed. The study thus, establishes that the levels of superoxide dismutase and catalase are increased in the initial stages of coronary artery disease to protect and prevent lipid peroxidation and both have therapeutic targets to act against reactive oxygen species in coronary artery disease but the levels are decreased thereafter with the severity of disease.
Gupta
Shailja
S
Sri Guru Ram Das Institute of Medical Sciences and Research, Department of Biochemistry, Vallah, Amritsar, India. shailja_gupta200828@yahoo.com
Sodhi
Sakshi
S
Mahajan
Vivek
V
D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002374:Catalase / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003324:Coronary Artery Disease / Q000097:blood* / Q000175:diagnosis / Q000201:enzymology; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology*; D008055:Lipids / Q000096:biosynthesis / Q000097:blood*; D008315:Malondialdehyde / Q000097:blood; D012307:Risk Factors; D013482:Superoxide Dismutase / Q000097:blood; D014280:Triglycerides / Q000097:blood; D014810:Vitamin E / Q000097:blood
D000975:Antioxidants; D015415:Biomarkers; D008078:Cholesterol, LDL; D008055:Lipids; D014280:Triglycerides; D014810:Vitamin E; D008315:Malondialdehyde; D002374:Catalase; D013482:Superoxide Dismutase