title: Efficacy of double arterial phase dynamic magnetic resonance imaging with the sensitivity encoding technique versus dynamic multidetector-row helical computed tomography for detecting hypervascular hepatocellular carcinoma.
abstract: OBJECTIVE
  The aim of this study was to evaluate the efficacy of double arterial phase dynamic magnetic resonance imaging (MRI) with the sensitivity encoding technique (SENSE dynamic MRI) for detection of hypervascular hepatocellular carcinoma (HCC) in comparison with double arterial phase dynamic multidetector-row helical computed tomography (dynamic MDCT).
  
  
  METHODS
  A total of 28 patients with 66 hypervascular HCCs underwent both double arterial SENSE dynamic MRI and dynamic MDCT. The diagnosis of HCC was based on surgical resection (n = 7), biopsy (n = 10), or a combination of CT during arterial portography (CTAP), CT during hepatic arteriography (CTA), and/or the 6-month follow-up CT (n = 49). Based on alternative-free response receiving operating characteristic (ROC) analysis, the diagnostic performance for detecting HCC was compared between double arterial phase SENSE dynamic MRI and double arterial phase dynamic MDCT.
  
  
  RESULTS
  The mean sensitivity, positive predictive value, and mean Az values for hypervascular HCCs were 72%, 80%, and 0.79, respectively, for SENSE dynamic MRI and 66%, 92%, and 0.78, respectively, for dynamic MDCT. The mean sensitivity for double arterial phase SENSE dynamic MRI was higher than that for double arterial phase dynamic MDCT, but the difference was not statistically significant.
  
  
  CONCLUSIONS
  Double arterial phase SENSE dynamic MRI is as valuable as double arterial phase dynamic MDCT for detecting hypervascular HCCs.
authors.affiliation: Department of Radiology, Kinki University School of Medicine, 377-2 Ohno-Higashi, Osakasayama 589-8511, Japan. kumano@radiol.med.kindai.ac.jp
authors.forename: Seishi
authors.initials: S
authors.lastname: Kumano
authors.forename: Masahiko
authors.initials: M
authors.lastname: Uemura
authors.forename: Toyoaki
authors.initials: T
authors.lastname: Haraikawa
authors.forename: Masaaki
authors.initials: M
authors.lastname: Hirata
authors.forename: Keiichi
authors.initials: K
authors.lastname: Kikuchi
authors.forename: Tonsok
authors.initials: T
authors.lastname: Kim
authors.forename: Masahiro
authors.initials: M
authors.lastname: Okada
authors.forename: Teruhito
authors.initials: T
authors.lastname: Mochizuki
authors.forename: Takamichi
authors.initials: T
authors.lastname: Murakami
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging* / Q000473:pathology*; D003287:Contrast Media; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D019786:Gadolinium DTPA; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D021621:Imaging, Three-Dimensional / Q000379:methods; D008099:Liver / Q000000981:diagnostic imaging / Q000473:pathology; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D012372:ROC Curve; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D036542:Tomography, Spiral Computed / Q000379:methods*
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA