Heart failure with preserved ejection fraction in older adults.
Age-associated physiologic changes predispose older adults to develop heart failure, even when left ventricular ejection fraction is normal or near normal. Heart failure with a preserved ejection fraction is particularly common in older hypertensive women, and hypertension plays a key role in its pathophysiology. In contrast with heart failure with a reduced ejection fraction, the treatment of heart failure with a preserved ejection fraction has a limited empiric basis, although some basic principles are useful. Ongoing studies provide hope of improving care of these patients.
Chen
Michael A
MA
Division of Cardiology, Harborview Medical Center, University of Washington, Seattle, WA 98104, USA. michen@u.washington.edu
D000375:Aging / Q000502:physiology*; D003971:Diastole; D006333:Heart Failure / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000503:physiopathology; D011379:Prognosis; D013318:Stroke Volume