Phenylethanoid glycosides from Lantana fucata with in vitro anti-inflammatory activity.
A phytochemical analysis of Lantana fucata dried leaves led to the isolation of three new phenylethanoid glycosides, fucatosides A-C, along with parvifloroside A and six known methoxyflavones. Their structures were established by NMR and ESIMS experiments. In vitro assays showed that the alcoholic extract and fucatoside C have significant anti-inflammatory effects, inhibiting NO release in the LPS-induced J774.A1 murine macrophage cell line.
Julião
Lisieux de Santana
Lde S
Programa de Biotecnologia Vegetal, Faculdade de Farmacia, Universidade Federal do Rio de Janeiro, CCS, Bl. A, 2 andar, Ilha do Fundao, 21.941-590, Rio de Janeiro, RJ, Brazil.
Piccinelli
Anna Lisa
AL
Marzocco
Stefania
S
Leitão
Suzana Guimarães
SG
Lotti
Cinzia
C
Autore
Giuseppina
G
Rastrelli
Luca
L
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001938:Brazil; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D032410:Lantana / Q000737:chemistry*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects*; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000378:metabolism; D019906:Nuclear Magnetic Resonance, Biomolecular; D010626:Phenylethyl Alcohol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*
C511910:2-(3,4-dihydroxyphenyl)-ethyl-O-alpha-L-rhamnopyranosyl-(1- 2)-4-O-E-caffeoyl-beta-D-glucopyranoside; D000894:Anti-Inflammatory Agents, Non-Steroidal; D006027:Glycosides; D008070:Lipopolysaccharides; C543956:fucatoside A; C543957:fucatoside B; C543958:fucatoside C; D009569:Nitric Oxide; D010626:Phenylethyl Alcohol