title: Negative pressure fixation device to reduce motion artifacts on contrast-enhanced MRI of the breast: a clinical feasibility study.
abstract: OBJECTIVE
  To investigate the effect of a negative pressure fixation device on misregistration artifacts in contrast-enhanced (CE) MR subtraction images.
  
  
  METHODS
  Nine patients, two of which had been previously diagnosed with breast cancer, were examined with T2-weighted (T2-w) turbo spin-echo (TSE) and three-dimensional (3D) spoiled gradient-recalled echo (SPGR) CE dynamic MRI. Baselines images were subtracted from the dynamic images. A device consisting of two stiff plastic domes was placed on the breasts of each patient. Negative pressure of 27 to 37 mmHg within the domes was maintained. The patient was positioned prone in the coil without the device and imaged as a baseline. Subsequently, the patient was placed into the negative pressure domes and reimaged. One of the nine patients was also imaged supine to establish feasibility for this positioning.
  
  
  RESULTS
  With the use of the negative pressure fixation device, a reduction in misregistration artifact has been demonstrated in prone imaging. Patients reported improved comfort with the device and feasibility has been shown for supine imaging.
  
  
  CONCLUSIONS
  The device was shown to be MRI-compatible and successfully applied in this pilot study, opening other avenues of exploration. Supine positioning for breast imaging makes possible better access for biopsy and intervention. Further modifications to the device are in order for this purpose and to eliminate motion due to breathing in the prone position.
authors.affiliation: Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
authors.forename: Asha
authors.initials: A
authors.lastname: Balakrishnan
authors.forename: Daniel F
authors.initials: DF
authors.lastname: Kacher
authors.forename: Eva
authors.initials: E
authors.lastname: Gombos
authors.forename: Darrell N
authors.initials: DN
authors.lastname: Smith
authors.forename: Macarena
authors.initials: M
authors.lastname: Carretero
authors.forename: Bill
authors.initials: B
authors.lastname: Leon
authors.forename: Carlos V
authors.initials: CV
authors.lastname: Freyre
authors.forename: Steven E
authors.initials: SE
authors.lastname: Chavoustie
mesh_terms: D000328:Adult; D016477:Artifacts; D001943:Breast Neoplasms / Q000473:pathology*; D003287:Contrast Media; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D009068:Movement; D011312:Pressure; D013382:Subtraction Technique
chemical_list: D003287:Contrast Media