Relationship between insulin sensitivity index and cognitive function in diet-induced insulin resistant rats.
Clinical and animal studies have revealed significant cognitive impairment in type II diabetic subjects. However, whether there is a relationship between insulin resistance and cognitive function is poorly understood. In the present study, we used a high fat diet to induce insulin resistance (IR) in rats, insulin sensitivity index (ISI) (= FINS x FPG/22.5) to assess the extent of insulin resistance and the Morris Water Maze Task to judge cognitive function. The relationship between insulin sensitivity index and cognitive function was determined by analysing the correlation between ISI and the time rat spent in targeted quadrant, as well as between ISI and the times the rat swam across the very point where a platform was previously placed, using Pearson's method. Perfect negative correlation between ISI and cognitive function existed when ISI fell within a certain range, which indicates that insulin resistance is associated with cognitive function impairment in some cases where ISI might be an indicator.
Chen
Sisi
S
Department of Pharmacology, China Pharmaceutical University, Nanjing, China.
Xie
Hao
H
Wu
Jing
J
Hong
Hao
H
Jin
Jianwen
J
Fang
Jinbo
J
Huang
Ji
J
Fu
Ying Zhou
YZ
Ji
Hui
H
Li
Yong Qi
YQ
Long
Yan
Y
Xia
Yuan Zheng
YZ
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D001786:Blood Glucose / Q000378:metabolism; D003071:Cognition / Q000502:physiology*; D004032:Diet / Q000009:adverse effects*; D018149:Glucose Intolerance; D005951:Glucose Tolerance Test; D007202:Indicators and Reagents; D007333:Insulin Resistance / Q000502:physiology*; D008055:Lipids / Q000097:blood; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D011597:Psychomotor Performance / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D015430:Weight Gain
D001786:Blood Glucose; D007202:Indicators and Reagents; D008055:Lipids