title: Relief of branch pulmonary artery stenosis reduces pulmonary valve insufficiency in a swine model.
abstract: OBJECTIVE
  We sought to determine the impact of relieving branch pulmonary artery stenosis on pulmonary valve insufficiency and right ventricular function. Long-standing pulmonary insufficiency causes progressive right ventricular dilatation, leading to decreased right ventricular function. Adults with pulmonary insufficiency are at risk of decreased exercise tolerance, arrhythmias, and sudden cardiac death. Branch pulmonary artery stenosis frequently occurs in these patients, and the presence of branch stenosis may exacerbate valve insufficiency.
  
  
  METHODS
  Neonatal piglets (n = 7) underwent surgery to create pulmonary insufficiency and left pulmonary artery stenosis. At 3 months of age, the animals underwent baseline cardiac magnetic resonance imaging followed by stenting of the left pulmonary artery. A repeat magnetic resonance imaging scan was performed 1 week after intervention. Magnetic resonance imaging evaluation included (1) velocity mapping to assess the forward and reverse flow at the main, left and right pulmonary arteries, and aorta; and (2) volumetric assessment of the right ventricle.
  
  
  RESULTS
  Left pulmonary artery flow increased from 14.5% to 36.3% of total net flow after stenting (P < .01). Pulmonary regurgitation decreased from 38.7% to 27.4% (P < .02). Right ventricular ejection fraction improved from a median of 53.5% to 58.2% after stenting (P < .01). Cardiac index improved from a median of 2.7 to 3.5 L/min/m(2) (P = .01).
  
  
  CONCLUSIONS
  Relief of branch pulmonary artery stenosis reduces insufficiency and improves right ventricular systolic function in this animal model. This supports the practice of aggressive intervention in patients with branch pulmonary artery stenosis and pulmonary insufficiency.
authors.affiliation: Division of Pediatric Cardiology, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA. cjpetit@texaschildrenshospital.org
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Petit
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Gillespie
authors.forename: Matthew A
authors.initials: MA
authors.lastname: Harris
authors.forename: Travis L
authors.initials: TL
authors.lastname: Seymour
authors.forename: Timothy Y
authors.initials: TY
authors.lastname: Liu
authors.forename: Azeem
authors.initials: A
authors.lastname: Khan
authors.forename: J William
authors.initials: JW
authors.lastname: Gaynor
authors.forename: Jonathan J
authors.initials: JJ
authors.lastname: Rome
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity; D003251:Constriction, Pathologic; D006439:Hemodynamics; D008279:Magnetic Resonance Imaging; D019028:Magnetic Resonance Imaging, Cine; D009206:Myocardium / Q000473:pathology; D011651:Pulmonary Artery / Q000473:pathology / Q000601:surgery*; D011665:Pulmonary Valve Insufficiency / Q000503:physiopathology* / Q000601:surgery; D034421:Sus scrofa; D016278:Ventricular Function, Right