Interplay between obesity and associated metabolic disorders: new insights into the gut microbiota.
Obesity and associated metabolic disorders are worldwide epidemic. The literature provides new evidence that gut microbiota dysbiosis (at the phyla, genus, or species level) affects host metabolism and energy storage. Here we discuss new findings that may explain how gut microbiota can be involved in the development or in the control of obesity and associated low-grade inflammation. New powerful molecular biology methods and the use of gnotobiotic animal allowed to analyze the molecular link between gut bacteria and the host. Moreover, even if more studies are needed to unravel how changing gut microbiota impacts on the development of obesity and related metabolic alterations, probiotic and prebiotic approach appear as potential interesting treatments to reverse host metabolic alterations linked to gut microbiota dysbiosis.
Cani
Patrice D
PD
Université catholique de Louvain, Louvain Drug Research Institute, Metabolism and Nutrition Research Group, PMNT Unit, Brussels, Belgium. patrice.cani@uclouvain.be
Delzenne
Nathalie M
NM
D000818:Animals; D001644:Bifidobacterium / Q000472:pathogenicity; D016503:Drug Delivery Systems; D041981:Gastrointestinal Tract / Q000382:microbiology* / Q000502:physiology; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000209:etiology; D024821:Metabolic Syndrome / Q000150:complications / Q000209:etiology*; D054892:Metagenome / Q000235:genetics*; D051379:Mice; D018345:Mice, Knockout; D008954:Models, Biological; D009765:Obesity / Q000150:complications / Q000209:etiology* / Q000628:therapy; D056692:Prebiotics; D019936:Probiotics / Q000627:therapeutic use
D056692:Prebiotics