[Expression and significance of the cyclin E in laryngeal carcinomas].
OBJECTIVE
To investigate the clinicopathological significance of the cyclin E expression in laryngeal squamous cell carcinomas (LSCCs).


METHODS
The expression of cyclin E was detected by immunohistochemistry method in 50 cases of LSCCs, 20 cases of dysplastic squamous epithelium and 10 polyps of vocal cord.


RESULTS
The positive expression of cyclin E was localized in the nuclei of cells. The positive rate of cyclin E protein in LSCCs, dysplastic squamous epithelium and polyps of vocal cord was 10% (1/10), 15% (3/20), 6% (3/50), respectively. There's no significant difference between them. While the expression of cyclin E in laryngeal cancer stromal vascular endothelial cells was significantly related with clinical stage and lymph node metastasis (P<0.01).


CONCLUSIONS
In LSCCs, the expression of cyclin E has non-specificity, probably it has no participate the malignant transform events of laryngeal cancer cells. However, cyclin E is sensitive to vasculogenesis relatively; the positive expression of cyclin E may evaluate the malignant phase of LSCCs indirectly.
Gao
Haiyan
H
Department of Otorhinolaryngology, the First Hospital of Inner Mongolia Medical College, Huhehaote, 010050, China. gaohaiyan456@sina.com
Li
Lingxiang
L
Peng
Shidong
S
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D019927:Cyclin E / Q000378:metabolism*; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis
D019927:Cyclin E