title: [Expression of annexin V in decidua tissues of preeclampsia patients].
abstract: OBJECTIVE
  To investigate the expression of annexin V in the decidua tissues of preeclampsia patients and explore its clinical significance.
  
  
  METHODS
  Real-time PCR, Western blotting and immunohistochemistry were employed to detect the mRNA and protein expressions of annexin V in the deciduas from 35 normal pregnant women at full term, 38 early onset severe preeclampsia patients and 33 late onset severe preeclampsia patients.
  
  
  RESULTS
  Annexin V was found on the cell membrane and in the cytoplasm of the decidual cells and stroma. Both the mRNA and protein of annexin V expressions in the decidua tissues were significantly different between normal pregnancy group and early or late onset severe preeclampsia group (P<0.05), being the highest in normal pregnancy group and the lowest in early onset severe preeclampsia group.
  
  
  CONCLUSIONS
  The low expression of annexin V in the deciduas might participate in the hypercoagulability state in preeclampsia patients.
authors.affiliation: Department of Obstetrics and Gynecology, Third Affiliated Hospital of Xiangya Medical College, Central South University, Changsha 410013, China. fengyl523@yahoo.com.cn
authors.forename: Ya-Ling
authors.initials: YL
authors.lastname: Feng
authors.forename: Chang-Ju
authors.initials: CJ
authors.lastname: Zhou
authors.forename: Min
authors.initials: M
authors.lastname: Xue
mesh_terms: D000328:Adult; D017304:Annexin A5 / Q000378:metabolism*; D016022:Case-Control Studies; D003656:Decidua / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D011225:Pre-Eclampsia / Q000378:metabolism* / Q000473:pathology; D011247:Pregnancy; D012333:RNA, Messenger / Q000235:genetics
chemical_list: D017304:Annexin A5; D012333:RNA, Messenger