title: [Anti-inflammatory and analgesic potency of carboxyamidotriazole, a tumoristatic agent].
abstract: OBJECTIVE
  To explore the potential anti-inflammatory and analgesic activities of carboxyamidotriazole (CAI).
  
  
  METHODS
  A variety of animal models, including the croton oil-induced ear edema, the cotton-induced granuloma, the rat adjuvant-induced arthritis, were used to evaluate anti-inflammatory effect of CAI. Vascular endothelial growth factor (VEGF)--or histamine-stimulated local vascular permeability in mouse modulated by CAI was also determined. In addition, we assessed the effect of CAI on the levels of proinflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-beta) at the site of inflammation and in sera. Moreover, antinociceptive effect of CAI on inflammatory pain was assessed using acetic acid-induced writhing model and the formalin test.
  
  
  RESULTS
  CAI significantly inhibited acute and chronic phases of inflammation, reduced VEGF or histamine-induced vascular permeability, and showed marked inhibition of proinflammatory cytokines such as TNF-alpha and IL-1 beta. CAI also showed potential therapeutic effect on peripheral inflammatory pain.
  
  
  CONCLUSIONS
  CAI is a promising anti-inflammatory and analgesic agent.
authors.affiliation: Department of Pharmacology, Institute of Basic Medical Sciences, CAMS and PUMC, Beijing 100005, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Guo
authors.forename: Juan
authors.initials: J
authors.lastname: Li
authors.forename: Hua
authors.initials: H
authors.lastname: Ye
authors.forename: Ru
authors.initials: R
authors.lastname: Zheng
authors.forename: Xiao-Jian
authors.initials: XJ
authors.lastname: Hao
authors.forename: Wen-Ying
authors.initials: WY
authors.lastname: Chen
authors.forename: Rui
authors.initials: R
authors.lastname: Jü
authors.forename: Yi-Ren
authors.initials: YR
authors.lastname: Yao
authors.forename: Hui-Fen
authors.initials: HF
authors.lastname: Yang
authors.forename: Xiao-Li
authors.initials: XL
authors.lastname: Yu
authors.forename: Cai-Ying
authors.initials: CY
authors.lastname: Ye
authors.forename: De-Chang
authors.initials: DC
authors.lastname: Zhang
mesh_terms: D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D005260:Female; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D051381:Rats; D017208:Rats, Wistar; D014230:Triazoles / Q000494:pharmacology*
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D014230:Triazoles; C062058:carboxyamido-triazole