title: Antinociceptive properties of caffeic acid derivatives in mice.
abstract: Ten ester derivatives from caffeic acid were synthesized, and their antinociceptive properties are evaluated in mice. The most active compound, dodecyl ester derivative, exhibited potent and dose-related activity against the writhing test, with a calculated ID(50) value of 15.1 (11.9-19.1)micromol/kg and MI of 78.8% being several times more active than reference drugs. It was also effective in other experimental models, such as formalin, capsaicin and glutamate-induced pain tests, but was inactive in the hot-plate test. Although the mechanism of action has still not been elucidated, these results appear to support its therapeutic potential against painful diseases.
authors.affiliation: Programa de Mestrado em Ciências Farmacêuticas e Núcleo de Investigações Químico - Farmacêuticas (NIQFAR)/CCS, Universidade do Vale do Itajaí, 88.302-202 Itajaí, SC, Brazil.
authors.forename: Fátima
authors.initials: F
authors.lastname: de Campos Buzzi
authors.forename: Caroline Liandra
authors.initials: CL
authors.lastname: Franzoi
authors.forename: Graziele
authors.initials: G
authors.lastname: Antonini
authors.forename: Mauricio
authors.initials: M
authors.lastname: Fracasso
authors.forename: Valdir
authors.initials: V
authors.lastname: Cechinel Filho
authors.forename: Rosendo Augusto
authors.initials: RA
authors.lastname: Yunes
authors.forename: Rivaldo
authors.initials: R
authors.lastname: Niero
mesh_terms: D000700:Analgesics / Q000737:chemistry* / Q000627:therapeutic use*; D000818:Animals; D002109:Caffeic Acids / Q000737:chemistry* / Q000627:therapeutic use*; D051379:Mice; D015394:Molecular Structure; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy*; D013329:Structure-Activity Relationship
chemical_list: D000700:Analgesics; D002109:Caffeic Acids; C040048:caffeic acid