title: Helicobacter pylori seropositivity and its relationship with serum malondialdehyde and lipid profile in preeclampsia.
abstract: OBJECTIVE
  To investigate Helicobacter pylori seropositivity rate in preeclamptic and healthy pregnants. Additionally, we compared serum malondialdehyde (MDA) levels and lipid profile between H. pylori-positive and negative cases.
  
  
  METHODS
  This study included 53 preeclamptic and 30 healthy pregnants. Serum levels of total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL-C) and low-density lipoprotein (LDL-C), MDA, and H. pylori Ig G antibodies were measured.
  
  
  RESULTS
  Preeclampsia group had higher serum MDA levels compared with healthy pregnants (P<0.001). While the rate of H. pylori seropositivity was 43/53 (81%) in the preeclampsia group, this was 18/30 (% 60) in normal pregnants (odds ratio (OR), 2.86; 95% confidence interval (CI), 1.05-7.82; P=0.036). We further divided the preeclampsia group as H. pylori-positive and H. pylori-negative subgroups. In H. pylori-positive group, serum TC (P<0.01) and LDL-C (P<0.01) levels were significantly higher than those of H. pylori-negative group. Mean MDA concentration was higher in H. pylori-positive group than that of H. pylori-negative group (P<0.001).
  
  
  CONCLUSIONS
  H. pylori-positive pregnants may have a high risk for preeclampsia and H. pylori may be one of the causes for high MDA levels in preeclampsia.
authors.affiliation: Department of Biochemistry, Medical School, Ataturk University, 25240 Erzurum, Turkey. aksoyhulya@yahoo.com
authors.forename: Hulya
authors.initials: H
authors.lastname: Aksoy
authors.forename: Asuman
authors.initials: A
authors.lastname: Ozkan
authors.forename: Ferda
authors.initials: F
authors.lastname: Aktas
authors.forename: Bunyamin
authors.initials: B
authors.lastname: Borekci
mesh_terms: D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood*; D001794:Blood Pressure / Q000502:physiology; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D005865:Gestational Age; D016481:Helicobacter Infections / Q000097:blood* / Q000382:microbiology; D016480:Helicobacter pylori / Q000276:immunology*; D006801:Humans; D008055:Lipids / Q000097:blood*; D008315:Malondialdehyde / Q000097:blood*; D018384:Oxidative Stress / Q000502:physiology; D011225:Pre-Eclampsia / Q000097:blood* / Q000382:microbiology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000097:blood* / Q000382:microbiology; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
chemical_list: D000907:Antibodies, Bacterial; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids; D014280:Triglycerides; D008315:Malondialdehyde; D002784:Cholesterol