Effects of variations in serum estradiol concentrations on secretory endometrial development and function in experimentally induced cycles in normal women.
Eighteen normal women underwent pituitary down-regulation with leuprolide, followed by a 10-day treatment with 0.2 mg/d transdermal estradiol (E(2)) with subsequent allocation to one of two 10-day estradiol regimens plus 40 mg daily intramuscular P: supraphysiologic (0.2 mg/d transdermal E(2) mg/d vaginal micronized E(2)) or subphysiologic (no exogenous E(2) treatment). Average E(2) and P in the supraphysiologic, physiologic, and subphysiologic groups were 1,175.9 pg/mL and 17.5 ng/mL, 136.9 pg/mL and 21.2 pg/mL, and 23.8 ng/mL and 22.0 ng/mL, respectively, and there were no differences between groups in endometrial histology or expression of biomarkers of receptivity.
Groll
Jeremy M
JM
Division of Reproductive Endocrinology and Infertility, Wright-Patterson AFB, Ohio 45433, USA. Jeremy.Groll@wpafb.af.mil
Usadi
Rebecca S
RS
Lessey
Bruce A
BA
Lininger
Ruth
R
Young
Steven L
SL
Fritz
Marc A
MA
D000293:Adolescent; D000328:Adult; D004717:Endometrium / Q000187:drug effects / Q000378:metabolism*; D004958:Estradiol / Q000097:blood*; D005260:Female; D005300:Fertility Agents, Female / Q000008:administration & dosage*; D006801:Humans; D039661:Integrin beta3 / Q000378:metabolism; D016729:Leuprolide / Q000008:administration & dosage*; D008183:Luteal Phase / Q000187:drug effects*; D053495:Osteopontin / Q000378:metabolism; D055815:Young Adult
D005300:Fertility Agents, Female; D039661:Integrin beta3; D053495:Osteopontin; D004958:Estradiol; D016729:Leuprolide