[Effect of low-flux polysulphone membranes on the serum levels of inflammatory cytokines, C-reactive protein, lipoprotein (a), and beta2 microglobulin in hemodialysis patients].
OBJECTIVE
To explore the effect of low-flux polysulphone membranes on the serum levels of inflammatory cytokines, hyper-sensitivity C reactive protein (hsCRP), lipoprotein (a) [Lp (a)], and beta2 microglobulin (beta 2MG) in hemodialysis patients.


METHODS
The blood samples and dialysate samples were collected at pre-dialysis, 120 minutes later during the session, and post-dialysis in 27 stable hemodialysis patients. Variables determined included serum Lp (a), hsCRP, interleukin (IL)-1 beta, IL-6, and beta 2MG. The endotoxin levels were also detected.


RESULTS
There were no significant changes either in endotoxin level of dialysate or in all variables tested during one session (P > 0.05).


CONCLUSIONS
Low-flux polysulphone membrane has no effects on serum Lp (a), hsCRP, IL-1 beta, IL-6, and beta 2MG during one session in hemodialysis patients.
Tao
Jian-Ling
JL
Department of Nephrology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
Sun
Yang
Y
Li
Xue-Mei
XM
Li
Hang
H
Wang
Yu-Ying
YY
Li
Xue-Wang
XW
D000328:Adult; D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism; D005260:Female; D006801:Humans; D053583:Interleukin-1beta / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D017270:Lipoprotein(a) / Q000097:blood; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D011108:Polymers; D006435:Renal Dialysis; D013450:Sulfones; D001613:beta 2-Microglobulin / Q000097:blood
D053583:Interleukin-1beta; D015850:Interleukin-6; D017270:Lipoprotein(a); D008567:Membranes, Artificial; D011108:Polymers; D013450:Sulfones; D001613:beta 2-Microglobulin; C017662:polysulfone P 1700; D002097:C-Reactive Protein