Influence of 70 nm silica particles in mice with cisplatin or paraquat-induced toxicity.
In the pharmaceutical industry, nano-size materials are designed as drug carriers and diagnosis probes. Interactions between nano-size materials and chemicals need investigating. Here, we investigated whether nano-size materials affect chemical-induced toxicity using silica particles, which have been widely used in cosmetics and drug delivery and have diameters of 70 (SP70), 300 (SP300) and 1000 (SP1000) nm, a popular anti-tumor agent, cisplatin, and a widely used herbicide, paraquat. Mice were treated with either cisplatin (100 micromol/kg, intraperitoneally) or paraquat (50 mg/kg, intraperitoneally), with or without intravenous silica particle administration. All treatments were non-lethal and did not show severe toxicity, except for injection with both cisplatin and SP70, which were lethal. When mice received with paraquat and/or the silica particles, synergistic enhanced toxicity was observed in both paraquat- and SP70-treated mice. These synergic effects were not observed with either Si300 or 1000 treatment. Our findings suggest that further evaluation on the interaction between nano-size materials and chemicals is critical for the pharmaceutical application of nanotechnology.
Nishimori
H
H
Laboratory of Bio-Functional Molecular Chemistry, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565-0871, Japan.
Kondoh
M
M
Isoda
K
K
Tsunoda
S
S
Tsutsumi
Y
Y
Yagi
K
K
D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D001219:Aspartate Aminotransferases / Q000097:blood; D001806:Blood Urea Nitrogen; D002945:Cisplatin / Q000633:toxicity*; D004357:Drug Synergism; D006540:Herbicides / Q000633:toxicity*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D053758:Nanoparticles; D010269:Paraquat / Q000633:toxicity*; D010316:Particle Size; D012822:Silicon Dioxide / Q000494:pharmacology*; D013535:Suspensions
D000970:Antineoplastic Agents; D006540:Herbicides; D013535:Suspensions; D012822:Silicon Dioxide; D001219:Aspartate Aminotransferases; D010269:Paraquat; D002945:Cisplatin