Proanthocyanidin to prevent formation of the reexpansion pulmonary edema.
BACKGROUND
We aimed to investigate the preventive effect of Proanthocyanidine (PC) in the prevention of RPE formation.


METHODS
Subjects were divided into four groups each containing 10 rats. In the Control Group (CG): RPE wasn't performed. Then subjects were followed up for three days and they were sacrificed after the follow up period. Samplings were made from tissues for measurement of biochemical and histopathologic parameters. In the Second Group (PCG): The same protocol as CG was applied, except the administration of PC to the subjects. In the third RPE Group (RPEG): Again the same protocol as CG was applied, but as a difference, RPE was performed. In the Treatment Group (TG): The same protocol as RPEG was applied except the administration of PC to the subjects.


RESULTS
In RPEG group, the most important histopathological finding was severe pulmonary edema with alveolar damage and acute inflammatory cells. These findings were less in the TG group. RPE caused increased MDA levels, and decreased GPx, SOD and CAT activity significantly in lung tissue.


CONCLUSIONS
PC decreased MDA levels. Oxidative stress plays an important role in pathophysiology of RPE and PC treatment was shown to be useful to prevent formation of RPE.
Yucel
Orhan
O
Department of Thoracic Surgery, Gulhane Military Medical Academy, Ankara, Turkey. orhanycl@gmail.com.
Ucar
Ergun
E
Tozkoparan
Ergun
E
Gunal
Armagan
A
Akay
Cemal
C
Sahin
Mehmet Ali
MA
Genc
Onur
O
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D002374:Catalase / Q000032:analysis; D002985:Clinical Protocols; D005979:Glutathione Peroxidase / Q000032:analysis; D008315:Malondialdehyde / Q000032:analysis; D044945:Proanthocyanidins / Q000627:therapeutic use*; D011654:Pulmonary Edema / Q000517:prevention & control*; D051381:Rats; D055502:Secondary Prevention; D018709:Statistics, Nonparametric; D013482:Superoxide Dismutase / Q000032:analysis; D016896:Treatment Outcome
D000975:Antioxidants; D044945:Proanthocyanidins; C013221:proanthocyanidin; D008315:Malondialdehyde; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase