Alpha,alpha-dicyanoalkenes: versatile vinylogous nucleophiles for organic synthesis.
Alpha,alpha-dicyanoalkenes are electron-deficient alkenes and inherently behave as electrophiles. Over the past five years some significant progress has been achieved by using alpha,alpha-dicyanoalkenes as vinylogous donors in C-C bond forming and other functionalisation reactions, especially for the construction of multifunctional products. In this feature article we will present the successful development of vinylogous reactions of alpha,alpha-dicyanoalkenes by our group and other groups.
Cui
Hai-Lei
HL
Key Laboratory of Drug-Targeting and Drug Delivery System of Education Ministry, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
Chen
Ying-Chun
YC
D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D004583:Electrons; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*; D055601:Organic Chemistry Phenomena; D013237:Stereoisomerism; D014753:Vinyl Compounds / Q000737:chemistry*
D000475:Alkenes; D009570:Nitriles; D014753:Vinyl Compounds