title: Cellulose-based dual graft molecular brushes as potential drug nanocarriers: stimulus-responsive micelles, self-assembled phase transition behavior, and tunable crystalline morphologies.
abstract: Well-defined cellulose-based dual graft molecular brushes, composed of ethyl cellulose-graft-poly(N,N-dimethylaminoethyl methacrylate)-graft-poly(epsilon-caprolactone) (EC-g-PDMAEMA-g-PCL), have been prepared by ring-opening polymerization (ROP) and atom transfer radical polymerization (ATRP). Unlike other brush copolymers, the new molecular brushes show some unique physicochemical properties and multifunction due to their unique topological structures. These biocompatible copolymers self-assembled to micelles in aqueous solution. Upon pH change, the single micelles further assembled into micellar aggregates. As a result, the micelles in aqueous media could act as excellent drug nanocarriers for controlled drug release. The crystallinity and crystal morphology of the copolymers can be controlled to a certain extent by varying the length of the side chains, which may exert strong spacial restriction and, hence, affect the crystal structures.
authors.affiliation: Department of Chemistry, Key Lab of Organic Optoelectronics & Molecular Engineering of Ministry of Education, Tsinghua University, Beijing 100084, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Yan
authors.forename: Jinying
authors.initials: J
authors.lastname: Yuan
authors.forename: Fengbo
authors.initials: F
authors.lastname: Zhang
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Sui
authors.forename: Xuming
authors.initials: X
authors.lastname: Xie
authors.forename: Yingwu
authors.initials: Y
authors.lastname: Yin
authors.forename: Shanfeng
authors.initials: S
authors.lastname: Wang
authors.forename: Yen
authors.initials: Y
authors.lastname: Wei
mesh_terms: D018906:Antineoplastic Agents, Alkylating / Q000737:chemistry*; D001672:Biocompatible Materials / Q000737:chemistry; D002152:Calorimetry, Differential Scanning; D002699:Chlorambucil / Q000737:chemistry*; D003094:Collagen / Q000737:chemistry*; D004337:Drug Carriers; D007834:Lasers; D009682:Magnetic Resonance Spectroscopy; D008567:Membranes, Artificial; D008823:Micelles; D018625:Microscopy, Atomic Force; D036103:Nanotechnology; D044367:Phase Transition; D011108:Polymers / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D018906:Antineoplastic Agents, Alkylating; D001672:Biocompatible Materials; D004337:Drug Carriers; D008567:Membranes, Artificial; D008823:Micelles; D011108:Polymers; D002699:Chlorambucil; D003094:Collagen