title: Hydrogen sulfide-induced hypometabolism prevents renal ischemia/reperfusion injury.
abstract: Hydrogen sulfide (H(2)S) can induce a hypometabolic, hibernation-like state in mammals when given in subtoxic concentrations. Pharmacologically reducing the demand for oxygen is a promising strategy to minimize unavoidable hypoxia-induced injury such as ischemia/reperfusion injury during renal transplantation. Here we show that H(2)S reduces metabolism in vivo, ex vivo, and in vitro. Furthermore, we demonstrate the beneficial effects of H(2)S-induced hypometabolism in a model of bilateral renal ischemia/reperfusion injury using three different treatment strategies. The results demonstrate striking protective effects on survival, renal function, apoptosis, and inflammation. A hypometabolic state induced by H(2)S might have therapeutic potential to protect kidneys that suffer from hypoxia.
authors.affiliation: Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. e.m.bos@path.umcg.nl
authors.forename: Eelke M
authors.initials: EM
authors.lastname: Bos
authors.forename: Henri G D
authors.initials: HG
authors.lastname: Leuvenink
authors.forename: Pauline M
authors.initials: PM
authors.lastname: Snijder
authors.forename: Niels J
authors.initials: NJ
authors.lastname: Kloosterhuis
authors.forename: Jan-Luuk
authors.initials: JL
authors.lastname: Hillebrands
authors.forename: Jaklien C
authors.initials: JC
authors.lastname: Leemans
authors.forename: Sandrine
authors.initials: S
authors.lastname: Florquin
authors.forename: Harry
authors.initials: H
authors.lastname: van Goor
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology; D000393:Air Pollutants / Q000494:pharmacology; D000818:Animals; D004195:Disease Models, Animal; D004734:Energy Metabolism / Q000187:drug effects; D006605:Hibernation / Q000502:physiology; D006862:Hydrogen Sulfide / Q000494:pharmacology*; D007674:Kidney Diseases / Q000378:metabolism* / Q000517:prevention & control*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D051381:Rats; D011916:Rats, Inbred F344; D015427:Reperfusion Injury / Q000378:metabolism* / Q000517:prevention & control*
chemical_list: D000393:Air Pollutants; D006862:Hydrogen Sulfide