title: Diversity in long-term synaptic plasticity at inhibitory synapses of striatal spiny neurons.
abstract: Procedural memories and habits are posited to be stored in the basal ganglia, whose intrinsic circuitries possess important inhibitory connections arising from striatal spiny neurons. However, no information about long-term plasticity at these synapses is available. Therefore, this work describes a novel postsynaptically dependent long-term potentiation (LTP) at synapses among spiny neurons (intrinsic striatal circuitry); a postsynaptically dependent long-term depression (LTD) at synapses between spiny and pallidal neurons (indirect pathway); and a presynaptically dependent LTP at strionigral synapses (direct pathway). Interestingly, long-term synaptic plasticity differs at these synapses. The functional consequences of these long-term plasticity variations during learning of procedural memories are discussed.
authors.affiliation: Departamento de Biofísica, Instituto de Fisiologia Celular-Neurociencias, Universidad Nacional Autonoma de México, México City, Distrito Federal, Mexico 04510.
authors.forename: Pavel E
authors.initials: PE
authors.lastname: Rueda-Orozco
authors.forename: Ernesto
authors.initials: E
authors.lastname: Mendoza
authors.forename: Ricardo
authors.initials: R
authors.lastname: Hernandez
authors.forename: Jose J
authors.initials: JJ
authors.lastname: Aceves
authors.forename: Osvaldo
authors.initials: O
authors.lastname: Ibanez-Sandoval
authors.forename: Elvira
authors.initials: E
authors.lastname: Galarraga
authors.forename: Jose
authors.initials: J
authors.lastname: Bargas
mesh_terms: D000818:Animals; D001479:Basal Ganglia / Q000166:cytology / Q000502:physiology*; D066298:In Vitro Techniques; D017774:Long-Term Potentiation / Q000502:physiology*; D036881:Long-Term Synaptic Depression / Q000502:physiology*; D009433:Neural Inhibition / Q000502:physiology; D009434:Neural Pathways / Q000166:cytology / Q000502:physiology; D009473:Neuronal Plasticity / Q000502:physiology*; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D055366:Synaptic Potentials / Q000502:physiology