title: Rhabdomyomatous well-differentiated liposarcoma arising in giant fibrovascular polyp of the esophagus.
abstract: We report an example of an esophageal giant fibrovascular polyp harboring a well-differentiated liposarcoma with rhabdomyomatous differentiation in a 68 year-old man. Initial imaging studies including fiberoptic endoscopy and 2 computed tomographic examinations, and laparoscopic myotomy failed to demonstrate the polypoid intraluminal nature of the lesion. Thus, alternative diagnoses including a malignant neoplasm and achalasia were entertained. A third computed tomography with contrast showed a pedunculated mass. Surgical resection revealed a 15-cm smooth-surfaced club-shaped mass composed of a well-differentiated liposarcoma demonstrating myoglobin, muscle-specific actin, and myogenin-positive rhabdomyomatous differentiation. To date, no previously reported giant fibrovascular polyp case has described a liposarcoma with rhabdomyomatous change.
authors.affiliation: Department of Pathology, Ohio State University, College of Medicine, Columbus, OH 43210, USA.
authors.forename: Joseph D
authors.initials: JD
authors.lastname: Jakowski
authors.forename: Paul E
authors.initials: PE
authors.lastname: Wakely
mesh_terms: D000199:Actins / Q000378:metabolism; D000368:Aged; D002454:Cell Differentiation; D004938:Esophageal Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008080:Liposarcoma / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D008297:Male; D018008:Myogenin / Q000378:metabolism; D009211:Myoglobin / Q000378:metabolism; D011127:Polyps / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D012207:Rhabdomyoma / Q000473:pathology
chemical_list: D000199:Actins; D018008:Myogenin; D009211:Myoglobin