title: The potential protective effect of low potassium dextran against lipid peroxidation in a rat lung transplantation model.
abstract: The overproduction of reactive oxygen species plays an important role in the cascade of events during lung ischemia-reperfusion leading to graft failure. An evaluation of the peripheral markers of oxidative stress and antioxidant enzyme activities was carried out after reperfusion in a rat lung transplant model. The decrease in lipid peroxidation immediately after transplantation ( P < 0.05) may suggest an adaptative response and/or a protective effect of low potassium dextran against lipid peroxidation through natural scavenging mechanisms.
authors.affiliation: Respirology, Porto Alegre General Hospital, 900035-903 Porto Alegre, Brazil.
authors.forename: R L
authors.initials: RL
authors.lastname: Torres
authors.forename: L K
authors.initials: LK
authors.lastname: Martins
authors.forename: M
authors.initials: M
authors.lastname: Picoral
authors.forename: J
authors.initials: J
authors.lastname: Auzani
authors.forename: T R G
authors.initials: TR
authors.lastname: Fernandes
authors.forename: I L S
authors.initials: IL
authors.lastname: Torres
authors.forename: M B C
authors.initials: MB
authors.lastname: Ferreira
authors.forename: C F
authors.initials: CF
authors.lastname: Andrade
authors.forename: A
authors.initials: A
authors.lastname: Belló-Klein
authors.forename: P F G
authors.initials: PF
authors.lastname: Cardoso
mesh_terms: D000818:Animals; D002374:Catalase / Q000378:metabolism; D003911:Dextrans / Q000494:pharmacology; D004912:Erythrocytes / Q000187:drug effects* / Q000201:enzymology; D016166:Free Radical Scavengers / Q000494:pharmacology*; D005947:Glucose / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects*; D016040:Lung Transplantation; D008297:Male; D023421:Models, Animal; D019188:Organ Preservation Solutions / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000097:blood / Q000517:prevention & control*; D013482:Superoxide Dismutase / Q000378:metabolism; D013997:Time Factors
chemical_list: D003911:Dextrans; D016166:Free Radical Scavengers; D019188:Organ Preservation Solutions; C083290:low potassium dextran glucose solution; D002374:Catalase; D013482:Superoxide Dismutase; D005947:Glucose