title: (1)H, (13)C and (15)N resonance assignment of 6aJL2(R25G), a highly fibrillogenic lambdaVI light chain variable domain.
abstract: An allotypic variation at position 25 influences the fibrillogenicity of lambdaVI light chains, which are related to humoral immune response and have been associated with AL amyloidosis. The full resonance assignment and a preliminary structural characterization of 6aJL2(R25G) are reported.
authors.affiliation: Departamento de Biotecnología, Universidad Autónoma Metropolitana-Iztapalapa, Mexico City, Mexico.
authors.forename: Luis H
authors.initials: LH
authors.lastname: Gutiérrez-González
authors.forename: Lucia
authors.initials: L
authors.lastname: Muresanu
authors.forename: Luis
authors.initials: L
authors.lastname: del Pozo-Yauner
authors.forename: Rosalba
authors.initials: R
authors.lastname: Sánchez
authors.forename: Leopoldo
authors.initials: L
authors.lastname: Guereca
authors.forename: Baltazar
authors.initials: B
authors.lastname: Becerril
authors.forename: Christian
authors.initials: C
authors.lastname: Lücke
mesh_terms: D000595:Amino Acid Sequence; D000682:Amyloid / Q000737:chemistry*; D002247:Carbon Isotopes / Q000737:chemistry; D007135:Immunoglobulin Variable Region / Q000737:chemistry*; D007146:Immunoglobulin lambda-Chains / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008970:Molecular Weight; D009587:Nitrogen Isotopes / Q000737:chemistry; D017434:Protein Structure, Tertiary; D011522:Protons
chemical_list: D000682:Amyloid; D002247:Carbon Isotopes; D007135:Immunoglobulin Variable Region; D007146:Immunoglobulin lambda-Chains; D009587:Nitrogen Isotopes; D011522:Protons