title: Antitubercular potential of plants: a brief account of some important molecules.
abstract: Mycobacterium tuberculosis is the most lethal pathogen causing tuberculosis in human. After the discovery of antitubercular drugs pyrazinamide, rifampicin, isoniazid, streptomycin, and ethambutol (PRISE), the disease was controlled for a limited period. However, over the course of their usage, the pathogen acquired resistance and evolved into multi-drug resistant, single-drug resistant, and extensive drug resistant forms. A good number of plant secondary metabolites are reported to have antitubercular activity comparable to the existing antitubercular drugs or sometimes even better in potency. A well-defined strategy is required to exploit these phytomolecules as antitubercular drugs. This review gives concise up-to-date information regarding the chemistry and pharmacology of plant-based leads and some insight into their structure-activity relationship.
authors.affiliation: Central Institute of Medicinal and Aromatic Plants, P.O. CIMAP, Kukrail Picnic Spot Road, Lucknow-226 015, India. arvindcimap@rediffmail.com
authors.forename: Arvind S
authors.initials: AS
authors.lastname: Negi
authors.forename: Jonnala K
authors.initials: JK
authors.lastname: Kumar
authors.forename: Suaib
authors.initials: S
authors.lastname: Luqman
authors.forename: Dharmendra
authors.initials: D
authors.lastname: Saikia
authors.forename: Suman P S
authors.initials: SP
authors.lastname: Khanuja
mesh_terms: D000995:Antitubercular Agents / Q000737:chemistry* / Q000145:classification / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D010944:Plants / Q000737:chemistry*; D014376:Tuberculosis / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology
chemical_list: D000995:Antitubercular Agents