[Evaluation of nasal absorption for geniposide solution].
OBJECTIVE
To investigate the regulation of geniposide nasal absorption.


METHODS
We used rat in situ nasal recirculation method as experimental model. The effects of perfusion volume, flow rate, perfusion concentration on nasal absorption of geniposide were studied.


RESULTS
Geniposide was stable in rats nasal lavage solution. At the perfusion volume 5 mL and flow rate 2.5 mL x min(-1), the absorption rate of geniposide remains constant in a dose-independent manner.


CONCLUSIONS
The mechanism of geniposide nasal absorption is passive diffusion following first order kinetics and the absorption rate constant is 4.20 x 10(-3).
Wan
Na
N
Key Laboratory of Modern Preparation of Traditional Chinese Medicine, Nanchang 330004, China.
Zhang
Haiyan
H
Xu
Runchun
R
Zheng
Qin
Q
Yang
Ming
M
D000042:Absorption; D000281:Administration, Intranasal; D000818:Animals; D004058:Diffusion; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000378:metabolism; D039823:Iridoids / Q000008:administration & dosage* / Q000378:metabolism*; D007700:Kinetics; D016014:Linear Models; D008297:Male; D009297:Nasal Mucosa / Q000378:metabolism*; D010477:Perfusion; D051381:Rats; D012680:Sensitivity and Specificity; D012996:Solutions
D004365:Drugs, Chinese Herbal; D039823:Iridoids; D012996:Solutions; C007835:geniposide