title: Model-based evolutionary analysis: the natural history of phage-shock stress response.
abstract: The evolution of proteins is inseparably linked to their function. Because most biological processes involve a number of different proteins, it may become impossible to study the evolutionary properties of proteins in isolation. In the present article, we show how simple mechanistic models of biological processes can complement conventional comparative analyses of biological traits. We use the specific example of the phage-shock stress response, which has been well characterized in Escherichia coli, to elucidate patterns of gene sharing and sequence conservation across bacterial species.
authors.affiliation: Division of Molecular Biosciences, Imperial College London, Centre for Bioinformatics, South Kensington, London SW7 2AZ, UK.
authors.forename: Maxime
authors.initials: M
authors.lastname: Huvet
authors.forename: Tina
authors.initials: T
authors.lastname: Toni
authors.forename: Hui
authors.initials: H
authors.lastname: Tan
authors.forename: Goran
authors.initials: G
authors.lastname: Jovanovic
authors.forename: Christoph
authors.initials: C
authors.lastname: Engl
authors.forename: Martin
authors.initials: M
authors.lastname: Buck
authors.forename: Michael P H
authors.initials: MP
authors.lastname: Stumpf
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D004926:Escherichia coli / Q000378:metabolism; D029968:Escherichia coli Proteins / Q000235:genetics / Q000378:metabolism; D019143:Evolution, Molecular; D006360:Heat-Shock Proteins / Q000235:genetics / Q000378:metabolism; D008962:Models, Theoretical
chemical_list: D001426:Bacterial Proteins; D029968:Escherichia coli Proteins; D006360:Heat-Shock Proteins; C069816:phage shock protein, Bacteria