title: Genotyping and antifungal drug susceptibility of the pathogenic yeast Trichosporon asahii isolated from Thai patients.
abstract: Trichosporonosis due to Trichosporon asahii is a life-threatening infection with a very poor prognosis. We analyzed the genotype of intergenic transcribed spacer (IGS) region 1 of the rRNA gene and determined the drug susceptibility of 101 T. asahii isolates obtained from Thai patients to collect basic information on trichosporonosis in Thailand. Of the five genotypes in the IGS region identified in this study, types 1 and 3 were predominant in Thailand. The distribution in Thailand differs from that in other countries, suggesting that there is a geographic substructure among T. asahii clinical isolates. Voriconazole appeared to be the most active drug.
authors.affiliation: Department of Medical Sciences, Mycology Laboratory, National Institute of Health, Nonthaburi, 11000, Thailand.
authors.forename: Nanthawan
authors.initials: N
authors.lastname: Mekha
authors.forename: Takashi
authors.initials: T
authors.lastname: Sugita
authors.forename: Reiko
authors.initials: R
authors.lastname: Ikeda
authors.forename: Akemi
authors.initials: A
authors.lastname: Nishikawa
authors.forename: Rinrapas
authors.initials: R
authors.lastname: Autthateinchai
authors.forename: Natteewan
authors.initials: N
authors.lastname: Poonwan
authors.forename: Pathom
authors.initials: P
authors.lastname: Sawanpanyalert
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology / Q000627:therapeutic use; D004271:DNA, Fungal / Q000032:analysis / Q000235:genetics; D021903:DNA, Ribosomal Spacer / Q000032:analysis / Q000235:genetics; D026141:Drug Resistance, Multiple, Fungal; D014644:Genetic Variation; D016681:Genome, Fungal; D005843:Geography; D006801:Humans; D008826:Microbial Sensitivity Tests; D009181:Mycoses / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology*; D011743:Pyrimidines / Q000494:pharmacology / Q000627:therapeutic use; D017422:Sequence Analysis, DNA; D013785:Thailand / Q000453:epidemiology; D014230:Triazoles / Q000494:pharmacology / Q000627:therapeutic use; D014250:Trichosporon / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D004271:DNA, Fungal; D021903:DNA, Ribosomal Spacer; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole