Clinical, radiological, and biochemical features of a bilateral buttock amyloidoma emerging after 27 years of hemodialysis.
Deposition of amyloid in the buttock is a rare complication of dialysis related amyloidosis (DRA), but this localization is even rarer in other types of amyloidoses. We report here the clinical, radiological, and biochemical features of a patient who incurred into this complication after 27 years of hemodialysis. Imaging of the amyloid deposition by magnetic resonance imaging (MRI) documents the amyloid infiltration in the muscles of the buttock region and highlights a peculiar feature of amyloid fibrils deposition in the subcutaneous fat. The amyloid deposition is confirmed by biochemical and microscopic analysis of fibrils extracted from a biopsy specimen. Review of literature and the features of this case lead to speculation that the peculiar involvement of the buttock region including muscles and subcutaneous fat in DRA might derive from the propagation of amyloid initially deposited in the hip joint.
Montagna
Giovanni
G
IRCCS Fondazione Salvatore Maugeri, Pavia, Italy.
Raimondi
Sara
S
Moro
Guido
G
Uggetti
Carla
C
Relini
Annalisa
A
Magrini
Umberto
U
Esposito
Gennaro
G
Giorgetti
Sofia
S
Congi
Luigi
L
Mosconi
Mario
M
Galli
Giovanni
G
Villa
Giuseppe
G
Segagni
Siro
S
Donadei
Simona
S
Obici
Laura
L
Merlini
Giampaolo
G
Stoppini
Monica
M
Bellotti
Vittorio
V
D000368:Aged; D000369:Aged, 80 and over; D000682:Amyloid / Q000737:chemistry / Q000378:metabolism; D000686:Amyloidosis / Q000209:etiology* / Q000378:metabolism / Q000473:pathology*; D001706:Biopsy; D002081:Buttocks / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D018625:Microscopy, Atomic Force; D008875:Middle Aged; D011859:Radiography; D006435:Renal Dialysis / Q000009:adverse effects*
D000682:Amyloid