title: A case of colonization of a prosthetic mitral valve by Acremonium strictum.
abstract: A case of colonization of a prosthetic mitral valve in a 73-year-old Spanish male by the fungus Acremonium strictum W. Gams is described. The valve was replaced due to paravalvular leak and severe insufficiency and the patient died of multiorgan failure. The identity of the fungus was determined by morphological studies and it was confirmed by the analysis of the ITS region sequence analysis. Molecular studies seem to demonstrate that A. strictum is a species complex. The case emphasizes the potential high risk of fungal infection for patients with prosthetic valves.
authors.affiliation: Unitat de Microbiologia, Facultat de Medicina, Universitat Rovira i Virgili, IISPR, Reus, Tarragona, España.
authors.forename: Josep
authors.initials: J
authors.lastname: Guarro
authors.forename: Amalia
authors.initials: A
authors.lastname: Del Palacio
authors.forename: Josep
authors.initials: J
authors.lastname: Gené
authors.forename: Josep
authors.initials: J
authors.lastname: Cano
authors.forename: Carmen Gómez
authors.initials: CG
authors.lastname: González
mesh_terms: D000164:Acremonium / Q000187:drug effects / Q000302:isolation & purification*; D000368:Aged; D000935:Antifungal Agents / Q000494:pharmacology / Q000627:therapeutic use; D016470:Bacteremia / Q000150:complications; D001483:Base Sequence; D003428:Cross Infection / Q000382:microbiology; D026141:Drug Resistance, Multiple, Fungal; D004696:Endocarditis / Q000150:complications / Q000382:microbiology*; D006350:Heart Valve Prosthesis / Q000009:adverse effects* / Q000382:microbiology; D006801:Humans; D008297:Male; D008943:Mitral Valve / Q000382:microbiology*; D008944:Mitral Valve Insufficiency / Q000150:complications / Q000382:microbiology; D008969:Molecular Sequence Data; D009102:Multiple Organ Failure / Q000209:etiology; D018410:Pneumonia, Bacterial / Q000150:complications; D016459:Prosthesis-Related Infections / Q000150:complications / Q000382:microbiology*; D012331:RNA, Fungal / Q000235:genetics; D012335:RNA, Ribosomal / Q000235:genetics; D012086:Reoperation
chemical_list: D000935:Antifungal Agents; D012331:RNA, Fungal; D012335:RNA, Ribosomal