title: Results of exercise stress testing in patients with diffuse pulmonary arteriovenous malformations.
abstract: Patients with diffuse pulmonary arteriovenous malformations (PAVMs) are subject to frequent complications and need to be followed closely. As part of this follow-up, we have employed exercise stress testing (EST) as an aid to assess their status. Twenty patients from a cohort of 35 with diffuse PAVMs have undergone EST using a standard cycle ergometer test. All patients had previously undergone pulmonary angiography, noncontrast chest computed tomography (CT), and repair of large focal PAVMs, prior to EST. Mean room air oxygen saturation at baseline and at maximum exercise (85% of maximum heart rate) were tabulated. Serial studies in six children and young adults were plotted by year and compared using the patient as their own control. Fourteen females and six males ranging in age from 4 to 50 years (mean 22 years) were studied. Baseline mean oxygen saturation was 84% and fell to 73% at maximum exercise. There was no significant difference between those with unilateral and bilateral involvement (P = 0.09). In four of the six patients with serial EST, the baseline and exercise oxygen saturations were quite stable. In the two patients who became symptomatic, with age, growth, and more activity, complete embolization of one or more segments of the lung improved their EST and functionality. Based on our previous work in patients with diffuse PAVMs, EST appears to offer a relatively safe and noninvasive method for assessing these patients. Our limited experience with serial EST suggests a good correlation with decreased functionality in these patients.
authors.affiliation: Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA. murphy_j@kids.wustl.edu
authors.forename: Joshua
authors.initials: J
authors.lastname: Murphy
authors.forename: Paola
authors.initials: P
authors.lastname: Pierucci
authors.forename: Deborah
authors.initials: D
authors.lastname: Chyun
authors.forename: Katharine J
authors.initials: KJ
authors.lastname: Henderson
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Pollak
authors.forename: Robert I
authors.initials: RI
authors.lastname: White
authors.forename: John
authors.initials: J
authors.lastname: Fahey
mesh_terms: D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D000792:Angiography; D001165:Arteriovenous Malformations / Q000000981:diagnostic imaging / Q000503:physiopathology*; D002648:Child; D002675:Child, Preschool; D005080:Exercise Test / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D011651:Pulmonary Artery / Q000002:abnormalities* / Q000000981:diagnostic imaging; D011667:Pulmonary Veins / Q000002:abnormalities* / Q000000981:diagnostic imaging; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed
chemical_list: D010100:Oxygen