title: [Particle radiotherapy for malignant gliomas].
abstract: Particle radiations using protons or carbons, and boron neutron capture therapy are emerging as a therapeutic modality for malignant gliomas. Some non-randomized prospective studies found favorable results; however, the advantageous method of advantage of conformal radiation using protons or carbon ions and tumor cell-selective radiation using boron neutron capture therapy have not been confirmed. In a recent clinical trial involving 20 newly diagnosed glioblastomas at the Proton Medical Research Center at Tsukuba, the median overall survival time and the 1- and 2-year survival rates were 21.6 months, 71.1% and 45.3%, respectively. In the clinical trial of boron neutron capture therapy of 15 newly diagnosed glioblastomas at Tsukuba, the median overall survival time and the 1- and 2-year survival rates were 25.7 month, 80.0% and 53.3%, respectively. The rationale, history, and clinical results of particle radiotherapy for glioblastoma were also discussed.
authors.affiliation: Graduate School of Comprehensive Human Science, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Koji
authors.initials: K
authors.lastname: Tsuboi
mesh_terms: D016754:Boron Neutron Capture Therapy; D001932:Brain Neoplasms / Q000532:radiotherapy*; D002250:Carbon Radioisotopes / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D005910:Glioma / Q000532:radiotherapy*; D006801:Humans; D017247:Neutron Capture Therapy / Q000295:instrumentation / Q000639:trends; D061766:Proton Therapy; D016896:Treatment Outcome
chemical_list: D002250:Carbon Radioisotopes