In vivo MRI cell tracking: clinical studies.
OBJECTIVE
The purpose of this review is to describe the principles of MRI cell tracking with superparamagnetic iron oxides and the four clinical trials that have been performed.


CONCLUSIONS
Clinical MRI cell tracking is likely to become an important tool at the bedside once (stem) cell therapy becomes mainstream. The most prominent role of this technique probably will be verification of accurate cell delivery with MRI-guided injection, in which interventional radiologists will play a role in the near future. All clinical studies described as of this writing have been performed outside the United States.
Bulte
Jeff W M
JW
Russell H. Morgan Department of Radiology, Division of MR Research, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. jwmbulte@mri.jhu.edu
D000328:Adult; D000368:Aged; D000818:Animals; D019496:Cancer Vaccines; D002465:Cell Movement; D017690:Cell Transplantation / Q000473:pathology*; D003287:Contrast Media; D003713:Dendritic Cells / Q000166:cytology; D005260:Female; D005290:Ferric Compounds; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D008207:Lymphatic Metastasis / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008545:Melanoma / Q000473:pathology / Q000556:secondary / Q000628:therapy; D051379:Mice; D012878:Skin Neoplasms / Q000473:pathology / Q000628:therapy; D013194:Staining and Labeling / Q000379:methods; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000166:cytology; D013552:Swine
D019496:Cancer Vaccines; D003287:Contrast Media; D005290:Ferric Compounds; C000499:ferric oxide