Applications of bioinformatics to protein structures: how protein structure and bioinformatics overlap.
In this chapter, we will focus on the role of bioinformatics to analyze a protein after its protein structure has been determined. First, we present how to validate protein structures for quality assurance. Then, we discuss how to analyze protein-protein interfaces and how to predict the biomolecule which is the biological oligomeric state of the protein. Finally, we discuss how to search for homologs based on the 3-D structure which is an essential step for understanding protein function.
Han
Gye Won
GW
Burnham Institute for Medical Research, La Jolla, CA, USA.
Rife
Chris
C
Sawaya
Michael R
MR
D019295:Computational Biology; D030562:Databases, Protein; D054730:Protein Interaction Domains and Motifs; D025941:Protein Interaction Mapping / Q000706:statistics & numerical data; D011506:Proteins / Q000737:chemistry*; D012984:Software; D040681:Structural Homology, Protein
D011506:Proteins