A review of ERGIC-53: its structure, functions, regulation and relations with diseases.
ERGIC-53 is a type I transmembrane protein. It includes an N-terminal signal sequence, a carbohydrate recognition domain, which is calcium-dependent and pH-sensitive, a stalk region, a transmembrane domain, and a short cytoplasmic domain; ERGIC-53 mainly acts as a receptor of a limited number of glycoprotein and transports them from ER to ERGIC and Golgi, meanwhile it has a secondary glycoprotein quality control function. Recent research has revealed that UPR, heat shock and VIPL may regulate the expression of ERGIC-53. F5F8D, and some ER storage diseases have relationship with ERGIC-53.
Zhang
Yong Ci
YC
State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, PR China.
Zhou
Yuan
Y
Yang
Chun Zheng
CZ
Xiong
D S
DS
D025861:Blood Coagulation Disorders, Inherited / Q000235:genetics; D004721:Endoplasmic Reticulum / Q000378:metabolism; D005165:Factor V / Q000235:genetics; D005169:Factor VIII / Q000235:genetics; D005786:Gene Expression Regulation; D005808:Genes, Recessive; D006023:Glycoproteins / Q000378:metabolism; D006056:Golgi Apparatus / Q000378:metabolism; D037241:Mannose-Binding Lectins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D008565:Membrane Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D011485:Protein Binding; D021382:Protein Sorting Signals; D017434:Protein Structure, Tertiary; D021381:Protein Transport; D033921:Vesicular Transport Proteins / Q000378:metabolism
D006023:Glycoproteins; C084004:LMAN1 protein, human; C475146:MCFD2 protein, human; D037241:Mannose-Binding Lectins; D008565:Membrane Proteins; D021382:Protein Sorting Signals; D033921:Vesicular Transport Proteins; D005165:Factor V; D005169:Factor VIII