title: Catalytic amide formation with alpha'-hydroxyenones as acylating reagents.
abstract: Alpha'-hydroxyenones undergo clean, catalytic amidations with amines promoted by the combination of an N-heterocyclic carbene and 1,2,4-triazole.
authors.affiliation: Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, USA.
authors.forename: Pei-Chen
authors.initials: PC
authors.lastname: Chiang
authors.forename: Yoonjoo
authors.initials: Y
authors.lastname: Kim
authors.forename: Jeffrey W
authors.initials: JW
authors.lastname: Bode
mesh_terms: D000215:Acylation; D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D006571:Heterocyclic Compounds / Q000737:chemistry; D007202:Indicators and Reagents / Q000737:chemistry*; D015394:Molecular Structure; D014230:Triazoles / Q000737:chemistry
chemical_list: D000577:Amides; D006571:Heterocyclic Compounds; D007202:Indicators and Reagents; D014230:Triazoles; C045575:1,2,4-triazole