title: Fatal cytotoxic cutaneous lymphoma presenting as ulcerative psoriasis.
abstract: BACKGROUND
  Psoriasis is a common, nonulcerative skin disorder.
  
  
  METHODS
  We describe 3 men recently referred to our institution for evaluation and treatment of severe, ulcerative psoriasis that ultimately was determined to be aggressive, cytotoxic, cutaneous lymphoma. Each had a history of relatively indolent, nonulcerative patches and plaques (duration, 2-45 years) that changed to ulcerated lesions; these rapidly progressed and eventuated in death.
  
  
  CONCLUSIONS
  The clinical characteristics of the skin lesions and the histopathologic findings form a distinct and rare presentation of cutaneous lymphoma. The initial course is similar to that of mycosis fungoides but eventuates in a highly aggressive disease with fatal outcome.
authors.affiliation: Department of Dermatology, Mayo Clinic, Rochester, MN 55905, USA. Weenig.Roger@mayo.edu
authors.forename: Roger H
authors.initials: RH
authors.lastname: Weenig
authors.forename: Nneka I
authors.initials: NI
authors.lastname: Comfere
authors.forename: Lawrence E
authors.initials: LE
authors.lastname: Gibson
authors.forename: Javier
authors.initials: J
authors.lastname: Alonso-Llamazares
authors.forename: Mark D P
authors.initials: MD
authors.lastname: Davis
authors.forename: Mark R
authors.initials: MR
authors.lastname: Pittelkow
authors.forename: Rokea A
authors.initials: RA
authors.lastname: el-Azhary
mesh_terms: D000368:Aged; D017809:Fatal Outcome; D006801:Humans; D016410:Lymphoma, T-Cell, Cutaneous / Q000150:complications* / Q000175:diagnosis*; D008875:Middle Aged; D011565:Psoriasis / Q000209:etiology*; D012878:Skin Neoplasms / Q000150:complications* / Q000175:diagnosis*; D012883:Skin Ulcer / Q000209:etiology*