title: Identification of a crenarchaeal orthologue of Elf1: implications for chromatin and transcription in Archaea.
abstract: The transcription machineries of Archaea and eukaryotes are similar in many aspects, but little is understood about archaeal chromatin and its role in transcription. Here, we describe the identification in hyperthermophilic Crenarchaeota and a Korarchaeon of an orthologue of the eukaryotic transcription elongation factor Elf1, which has been shown to function in chromatin structure maintenance of actively transcribed templates. Our discovery has implications for the relationship of chromatin and transcription in Archaea and the evolution of these processes in eukaryotes.
authors.affiliation: Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK. jan-peter.daniels@path.ox.ac.uk
authors.forename: Jan-Peter
authors.initials: JP
authors.lastname: Daniels
authors.forename: Steven
authors.initials: S
authors.lastname: Kelly
authors.forename: Bill
authors.initials: B
authors.lastname: Wickstead
authors.forename: Keith
authors.initials: K
authors.lastname: Gull
mesh_terms: D001105:Archaea / Q000235:genetics*; D019843:Archaeal Proteins / Q000235:genetics* / Q000378:metabolism*; D002843:Chromatin / Q000235:genetics*; D019615:Crenarchaeota / Q000235:genetics*; D019143:Evolution, Molecular; D019848:Gene Expression Regulation, Archaeal / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics*
chemical_list: D019843:Archaeal Proteins; D002843:Chromatin; D014157:Transcription Factors