title: Ras/MAPK signaling from endomembranes.
abstract: Signal transduction along the Ras/MAPK pathway has been generally thought to take place at the plasma membrane. It is now evident that the plasma membrane is not the only platform capable of Ras/MAPK signal induction. Fusion of Ras with green fluorescent protein and the development of genetically encoded fluorescent probes for Ras activation have revealed signaling events on a variety of intracellular membranes including endosomes, the Golgi apparatus and the endoplasmic reticulum. Thus, the Ras/MAPK pathway is spatially compartmentalized within cells and this may afford greater complexity of signal output.
authors.affiliation: Department of Cell Biology, NYU School of Medicine, New York, NY 10016, USA.
authors.forename: Nicole
authors.initials: N
authors.lastname: Fehrenbacher
authors.forename: Dafna
authors.initials: D
authors.lastname: Bar-Sagi
authors.forename: Mark
authors.initials: M
authors.lastname: Philips
mesh_terms: D011992:Endosomes / Q000378:metabolism; D005260:Female; D006056:Golgi Apparatus / Q000378:metabolism; D006801:Humans; D007425:Intracellular Membranes / Q000378:metabolism*; D008297:Male; D020929:Mitogen-Activated Protein Kinase Kinases / Q000235:genetics / Q000378:metabolism*; D008954:Models, Biological; D015398:Signal Transduction; D018631:ras Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D020929:Mitogen-Activated Protein Kinase Kinases; D018631:ras Proteins