Targeting IGF-1R in the treatment of sarcomas: past, present and future.
The use of multimodality therapy has resulted in markedly improved cure rates for patients with sarcomas in the past 25 years. However, for virtually all patients with metastatic or recurrent disease, survival remains dismal. The important role that members of the insulin-like growth factor (IGF) family play in tumorigenesis has been known for decades. But it has only been in the last five years, that humanized and fully human antibodies targeting insulin-like growth factor receptor 1 (IGF-1R) have been developed. The use of these agents in clinical trials has been accompanied by several dramatic responses in patients with recurrent and refractory sarcomas. In this review, we will focus on preclinical highlights in the past, current clinic trials and discuss some exciting research opportunities to foster advances in the future.
Kim
Su Young
SY
Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. kimsuyou@mail.nih.gov
Wan
Xiaolin
X
Helman
Lee J
LJ
D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000627:therapeutic use; D019008:Drug Resistance, Neoplasm; D005544:Forecasting; D006801:Humans; D051379:Mice; D017526:Receptor, IGF Type 1 / Q000037:antagonists & inhibitors*; D012509:Sarcoma / Q000378:metabolism / Q000628:therapy*; D013002:Somatomedins / Q000378:metabolism
D000911:Antibodies, Monoclonal; D000970:Antineoplastic Agents; D013002:Somatomedins; D017526:Receptor, IGF Type 1