title: Synthesis and in-vitro anti-hepatitis-B virus activity of 6H-[1]benzothiopyrano[4,3-b] quinolin-10-ols.
abstract: A series of 9-methoxy-6H-[1]benzothiopyrano[4,3-b]quinolin-10-ols with a Mannich side chain were synthesized and evaluated for their anti-Hepatitis B virus (HBV) activity in HepG2.2.15 cells. Some compounds showed significant anti-HBV activity with IC(50) values less than 41 microM. Among them, compound 9b was the most effective anti-HBV agent (IC(50) = 1.7 microM, SI = 60.3).
authors.affiliation: School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Jia
authors.forename: Yanfang
authors.initials: Y
authors.lastname: Zhao
authors.forename: Rongdong
authors.initials: R
authors.lastname: Li
authors.forename: Yanjiao
authors.initials: Y
authors.lastname: Wu
authors.forename: Zebiao
authors.initials: Z
authors.lastname: Li
authors.forename: Ping
authors.initials: P
authors.lastname: Gong
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects*; D004279:DNA, Viral / Q000378:metabolism; D004353:Drug Evaluation, Preclinical; D024882:Drug Resistance, Viral; D006515:Hepatitis B virus / Q000187:drug effects* / Q000378:metabolism; D006912:Hydroxyquinolines / Q000494:pharmacology*; D019259:Lamivudine / Q000494:pharmacology; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D000998:Antiviral Agents; D004279:DNA, Viral; D006912:Hydroxyquinolines; D019259:Lamivudine