Alterations of nocturnal activity in rats following subchronic oral administration of the neurotoxin 1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline.
1-Trichloromethyl-1,2,3,4-tetrahydro-beta-carboline (TaClo) is neurotoxic when administered to the brain and alters motor behaviour following intraperitoneal administration. We have assessed the long-term effects of oral TaClo administration on nocturnal motor behaviour in rats. Two groups of rats received TaClo orally at a dose of either 0.2 or 0.4 mg/kg twice daily for 7 weeks. The control group was given saline. No change in locomotor activity was observed 4-9 days after the end of the 7-week administration of TaClo. In addition, the spontaneous motor activity was altered dose-dependently 9 months after oral TaClo administration, with an increase in the low-dose TaClo group and a decrease in the high-dose group. Oral administration of TaClo in rats may be useful in investigating the hypothesis that in Parkinson's disease, an unknown pathogenic factor crossing the intestinal mucosa barrier can induce neurodegenerative processes eventually affecting the entire brain.
Sontag
Thomas A
TA
Department of Experimental Psychology, University of Regensburg, 93040, Regensburg, Germany. thomas-alexander.sontag@psychologie.uni-regensburg.de
Lange
Klaus W
KW
Heim
Christine
C
Kolasiewicz
Waclav
W
Tucha
Oliver
O
Sontag
Karl-Heinz
KH
D000818:Animals; D002243:Carbolines / Q000008:administration & dosage / Q000494:pharmacology*; D003624:Darkness; D004305:Dose-Response Relationship, Drug; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D009498:Neurotoxins / Q000008:administration & dosage / Q000494:pharmacology*; D017440:Photoperiod; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D002243:Carbolines; D009498:Neurotoxins; C067372:1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline