Design, synthesis, enzyme inhibition, and tumor cell growth inhibition of 2-anilinobenzamide derivatives as SIRT1 inhibitors.
A series of 2-anilinobenzamide derivatives were designed, synthesized and evaluated for their SIRT1-inhibitory activity. Among these, compounds 3 and 5 inhibited SIRT1 activity in enzyme assays and suppressed the growth of Daudi and HCT116 cells.
Suzuki
Takayoshi
T
Nagoya City University, Tanabe-dori, Mizuho-ku, Aichi, Japan. suzuki@phar.nagoya-cu.ac.jp
Imai
Keiko
K
Imai
Erika
E
Iida
Shinsuke
S
Ueda
Ryuzo
R
Tsumoto
Hiroki
H
Nakagawa
Hidehiko
H
Miyata
Naoki
N
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001549:Benzamides / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D001713:Biphenyl Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D003198:Computer Simulation; D015195:Drug Design; D006131:Growth Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D045325:HCT116 Cells; D006801:Humans; D017434:Protein Structure, Tertiary; D056564:Sirtuin 1; D037761:Sirtuins / Q000037:antagonists & inhibitors* / Q000378:metabolism
C544480:2-(3-phenoxyphenylamino)benzamide; C544481:2-(biphenyl-3-ylamino)benzamide; D000970:Antineoplastic Agents; D001549:Benzamides; D001713:Biphenyl Compounds; D006131:Growth Inhibitors; C037689:benzamide; C447939:SIRT1 protein, human; D056564:Sirtuin 1; D037761:Sirtuins