Catalytic amide formation with alpha'-hydroxyenones as acylating reagents.
Alpha'-hydroxyenones undergo clean, catalytic amidations with amines promoted by the combination of an N-heterocyclic carbene and 1,2,4-triazole.
Chiang
Pei-Chen
PC
Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, USA.
Kim
Yoonjoo
Y
Bode
Jeffrey W
JW
D000215:Acylation; D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D006571:Heterocyclic Compounds / Q000737:chemistry; D007202:Indicators and Reagents / Q000737:chemistry*; D015394:Molecular Structure; D014230:Triazoles / Q000737:chemistry
D000577:Amides; D006571:Heterocyclic Compounds; D007202:Indicators and Reagents; D014230:Triazoles; C045575:1,2,4-triazole