title: The evolution of protein functions and networks: a family-centric approach.
abstract: The study of superfamilies of protein domains using a combination of structure, sequence and function data provides insights into deep evolutionary history. In the present paper, analyses of functional diversity within such superfamilies as defined in the CATH-Gene3D resource are described. These analyses focus on structure-function relationships in very large and diverse superfamilies, and on the evolution of domain superfamily members in protein-protein complexes.
authors.affiliation: Department of Structural and Molecular Biology, University College London, London WC1E 6BT, UK.
authors.forename: Benoît H
authors.initials: BH
authors.lastname: Dessailly
authors.forename: Adam J
authors.initials: AJ
authors.lastname: Reid
authors.forename: Corin
authors.initials: C
authors.lastname: Yeats
authors.forename: Jonathan G
authors.initials: JG
authors.lastname: Lees
authors.forename: Alison
authors.initials: A
authors.lastname: Cuff
authors.forename: Christine A
authors.initials: CA
authors.lastname: Orengo
mesh_terms: D000818:Animals; D030562:Databases, Protein; D019143:Evolution, Molecular; D006801:Humans; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry* / Q000145:classification / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: D011506:Proteins