title: Palladium-catalyzed aromatic C-H halogenation with hydrogen halides by means of electrochemical oxidation.
abstract: A new strategy for catalytic functionalization of C-H bonds by means of electrochemical oxidation is described. Combination of palladium-catalyzed aromatic C-H bond cleavage and halogenation with electrochemically generated halonium ions enables highly efficient, selective halogenations of aromatic compounds in a green-sustainable manner. The required reagents for this reaction are an arene and an aqueous hydrogen halide as substrates, a palladium salt as a catalyst, and an organic solvent. No further additives such as electrolytes, oxidants, or ligands are necessary to achieve effective catalytic activity. Several remarkable advantages of the use of the electrochemical method are also described.
authors.affiliation: Department of Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, Kanagawa 223-8522, Japan. kakiuchi@chem.keio.ac.jp
authors.forename: Fumitoshi
authors.initials: F
authors.lastname: Kakiuchi
authors.forename: Takuya
authors.initials: T
authors.lastname: Kochi
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Mutsutani
authors.forename: Noboru
authors.initials: N
authors.lastname: Kobayashi
authors.forename: Seiya
authors.initials: S
authors.lastname: Urano
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Sato
authors.forename: Shigeru
authors.initials: S
authors.lastname: Nishiyama
authors.forename: Takamasa
authors.initials: T
authors.lastname: Tanabe