Unusual cellular uptake of cytotoxic 4-hydroxymethyl-3-aminoacridine.
Aminoacridine derivatives display interesting chemical and biological properties in the field of antitumor agents. The synthesis of 4-hydroxymethyl-3-aminoacridine and its iodo labelled analogue allows the study of cell distribution using two innovative, complementary and powerful techniques, real time fluorescence microscopy and dynamic secondary ion mass spectrometry (SIMS). All the data point to lysosomal localization of the active molecule.
Peixoto
Paul
P
Faculté de médecine de Lille, IRCL and IMPRT, Inserm U837, Centre Oscar Lambret, Université Lille Nord de France, France.
Zeghida
Walid
W
Carrez
Danièle
D
Wu
Ting-Di
TD
Wattez
Nicole
N
Croisy
Alain
A
Demeunynck
Martine
M
Guerquin-Kern
Jean-Luc
JL
Lansiaux
Amélie
A
D000166:Acridines / Q000493:pharmacokinetics* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000493:pharmacokinetics* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002463:Cell Membrane Permeability; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D008247:Lysosomes / Q000378:metabolism*; D008856:Microscopy, Fluorescence; D018629:Spectrometry, Mass, Secondary Ion
C472795:4-hydroxymethyl-3-aminoacridine; D000166:Acridines; D000970:Antineoplastic Agents