title: [Biochemical markers of bone turnover. New aspect. Biomarkers of cartilage metabolism].
abstract: Osteoarthritis (OA) is characterized by increased cartilage degradation and wearing. The principal disease hallmarks for assessment of OA are radiographic aspects. However, laboratory markers of joint fluid, serum or urine have received growing attention in recent years. Biomarkers should be useful for improvement of diagnosis, assessment of disease progression and evaluation of therapeutic effects in OA. Here we described the outline of biomarkers in cartilage including utility and weakness.
authors.affiliation: Department of Orthopaedic Surgery, Osaka City University Medical School.
authors.forename: Tadashi
authors.initials: T
authors.lastname: Okano
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Koike
mesh_terms: D015415:Biomarkers; D002356:Cartilage / Q000378:metabolism*; D002809:Chondroitin Sulfates; D024042:Collagen Type I; D024043:Collagen Type II; D042241:Early Diagnosis; D006801:Humans; D006820:Hyaluronic Acid; D007632:Keratan Sulfate; D020782:Matrix Metalloproteinases; D010003:Osteoarthritis / Q000175:diagnosis* / Q000378:metabolism; D010455:Peptides; D011509:Proteoglycans
chemical_list: D015415:Biomarkers; D024042:Collagen Type I; D024043:Collagen Type II; D010455:Peptides; D011509:Proteoglycans; C052929:collagen type I trimeric cross-linked peptide; D006820:Hyaluronic Acid; D002809:Chondroitin Sulfates; D007632:Keratan Sulfate; D020782:Matrix Metalloproteinases