Cardiolipin-enriched raft-like microdomains are essential activating platforms for apoptotic signals on mitochondria.
Cardiolipin (CL) has recently been shown to provide an anchor and an essential activating platform for caspase-8 on mitochondria. We hypothesize that these platforms may correspond to "raft-like" microdomains, which have demonstrated to be detectable on mitochondrial membrane of cells undergoing apoptosis. The role for CL in "raft-like" microdomains could be to anchor caspase-8 at contact sites between inner and outer membranes, facilitating its self-activation, Bid cleavage and apoptosis execution. The role played by "raft-like" microdomains in the apoptotic program could introduce a new task in the pathogenetic studies on human diseases associated with cardiolipin dismetabolism.
Sorice
Maurizio
M
Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy. maurizio.sorice@uniroma1.it
Manganelli
Valeria
V
Matarrese
Paola
P
Tinari
Antonella
A
Misasi
Roberta
R
Malorni
Walter
W
Garofalo
Tina
T
D017209:Apoptosis / Q000502:physiology*; D002308:Cardiolipins / Q000378:metabolism*; D006801:Humans; D021962:Membrane Microdomains / Q000737:chemistry / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism* / Q000648:ultrastructure; D051336:Mitochondrial Membranes / Q000737:chemistry / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology
D002308:Cardiolipins