Association of pretransplant soluble glycoprotein 130 (sgp130) plasma levels and posttransplant acute tubular necrosis in renal transplant recipients.
OBJECTIVE
Previously, we reported that high pretransplant sIL-6R plasma levels are associated with posttransplant acute tubular necrosis (ATN). In this study, we examined associations of pretransplant plasma levels of sgp130 with ATN.


METHODS
Pretransplant serum creatinine (Cr), plasma neopterin, and sgp130 levels were studied in 105 first renal transplant recipients who received grafts from deceased donors. Although 57 patients had immediate and sustained graft function, ATN was diagnosed in 30 patients within the first 11.3+/-7.8 posttransplant days and acute rejection in 18 patients during the first 27.1+/-27.6 days.


RESULTS
Pretransplant serum Cr and plasma neopterin were similar in the three patient groups. Pretransplant sgp130 plasma levels, however, were significantly lower in patients with ATN than in patients with immediate graft function (P=0.004) or acute rejection (P=0.009). Multivariable logistic regression analysis for ATN showed an odds ratio of 4.3 of patients with pretransplant sgp130 less than or equal to 250 pg/mL with posttransplant ATN (P=0.006).


CONCLUSIONS
Patients at risk of ATN showed immediately before transplantation low anti-inflammatory sgp130, suggesting a contribution of the IL-6 cytokine family to the development of ATN. It might be useful to measure IL-6 family plasma levels pretransplant to identify patients who are at an increased risk of developing ATN.
Sadeghi
Mahmoud
M
Department of Transplantation Immunology, University of Heidelberg, D-69120 Heidelberg, Germany. Mahmoud.Sadeghi@med.uni-heidelberg.de
Daniel
Volker
V
Lahdou
Imad
I
Döhler
Bernd
B
Naujokat
Cord
C
Renner
Fabrice C
FC
Weimer
Rolf
R
Fonouni
Hamidreza
H
Mehrabi
Arianeb
A
Schmidt
Jan
J
Schenk
Martin
M
Zeier
Martin
M
Opelz
Gerhard
G
D000328:Adult; D000368:Aged; D003404:Creatinine / Q000097:blood; D050822:Cytokine Receptor gp130 / Q000097:blood*; D016207:Cytokines / Q000097:blood / Q000276:immunology; D005260:Female; D006084:Graft Rejection / Q000097:blood / Q000276:immunology; D006085:Graft Survival / Q000276:immunology; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D016030:Kidney Transplantation / Q000276:immunology / Q000502:physiology*; D007683:Kidney Tubular Necrosis, Acute / Q000097:blood* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D019798:Neopterin / Q000097:blood; D016017:Odds Ratio; D011183:Postoperative Complications / Q000097:blood*; D012044:Regression Analysis
D016207:Cytokines; D015850:Interleukin-6; D050822:Cytokine Receptor gp130; D019798:Neopterin; D003404:Creatinine