title: Cerebrospinal fluid and serum NT-proBNP concentrations in children with epilepsy.
abstract: BACKGROUND
  The cardio-neuro-endocrine axis seems to be involved in the cascade of postictal events in children. The aim of this study was to assess the relationship between childhood epilepsy and cerebrospinal fluid (CSF) or serum concentrations of the N-terminal pro B-type natriuretic peptide (NT-proBNP) interictally.
  
  
  METHODS
  A total of seventy-four children agreed to participate in the study. Twenty-two children with epilepsy and mild developmental delay (mean+/-SD [median] age 5.8+/-4.9 [4.3] years), 15 children with newly diagnosed multiple sclerosis (MS) (15.1+/-1.4 [15.3] years) and 37 children with cryptogenic mild developmental delay (8.0+/-4.6 [7.4] years), serving as controls, were eligible.
  
  
  RESULTS
  In children with epilepsy, interictal CSF NT-proBNP concentrations were greater when compared to the MS group and to controls (mean+/-SD [median] 193.0+/-78.1 [176.0]ng/L vs. 147.8+/-60.2 [138.0]ng/L vs. 140.4+/-36.5 [134.0]ng/L; p=0.014 and p=0.009). In contrast, serum NT-proBNP concentrations and the CSF/serum NT-proBNP ratio did not differ between groups.
  
  
  CONCLUSIONS
  Greater CSF NT-proBNP concentrations in children with epilepsy may reflect an unspecific activation of the cardio-neuro-endocrine system involving endocrinological stress-response mechanisms interictally. The relationship between epilepsy and the cardio-neuro-endocrine axis may further the understanding of seizure susceptibility in children as well as influences of epilepsy on central modulation of autonomic cardiovascular control.
authors.affiliation: Department of Pediatrics IV, Division of Neuropediatrics, Medical University Innsbruck, Austria. markus_rauchenzauner@hotmail.com
authors.forename: Markus
authors.initials: M
authors.lastname: Rauchenzauner
authors.forename: Edda
authors.initials: E
authors.lastname: Haberlandt
authors.forename: Carla
authors.initials: C
authors.lastname: Rösslhuber
authors.forename: Gerhard
authors.initials: G
authors.lastname: Luef
authors.forename: Markus
authors.initials: M
authors.lastname: Otto
authors.forename: Angelika
authors.initials: A
authors.lastname: Hammerer-Lercher
authors.forename: Andrea
authors.initials: A
authors.lastname: Griesmacher
authors.forename: Kevin
authors.initials: K
authors.lastname: Rostasy
mesh_terms: D000293:Adolescent; D000704:Analysis of Variance; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D004827:Epilepsy / Q000097:blood* / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D007118:Immunoassay; D008297:Male; D009103:Multiple Sclerosis / Q000097:blood* / Q000134:cerebrospinal fluid*; D020097:Natriuretic Peptide, Brain / Q000097:blood* / Q000134:cerebrospinal fluid*; D018579:Patient Selection; D010446:Peptide Fragments / Q000097:blood* / Q000134:cerebrospinal fluid*; D013129:Spinal Puncture
chemical_list: D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain