[Variability of breathing pattern during inspiratory elastic load].
In humans, lung ventilation exhibits breath-to-breath variability and dynamics that are nonlinear, complex and chaotic. Our objective was to characterize the breathing pattern variational activity in anesthetized dogs (n: 8) breathing through threshold inspiratory elastic load (7 to 50 cm H2O). Starting from flow signal and tracheal and esophageal pressures, we analyzed inspiratory time (Ti), timing (expiratory time, Te; total time, Ttot; and Ti/Ttot) and central drive (Vt/Ti) and variables related to it (tidal volume, Vt and pulmonary ventilation, Ve). We measured gross variability (variances), low frequency oscillations (spectral analysis), and short term memory (autocorrelation analysis). Loading decreased variance of the mean values of Te, Ttot, Vt and Vt/Ti (p < 0.05); the mean of variances for Ti/Ttot increased (p < 0.005) while it decreased for Vt and Vt/Ti (p < 0.05). In general, percent of data recordings with low frequency oscillations (OB%) decreased (p < 0.02). During heavy load, timing parameters percent of data recordings with autocorrelations (AU%) did not change, but Vt and its related parameters decreased their AU% (p < 0.005). There was a positive correlation (r: 0.955, p < 0.001) between the existence of low frequency oscillations and autocorrelations for Vt and its related parameters, while timing variables did not show such a correlation. In conclusion, threshold elastic load induced a monotonous respiratory pattern. The short term memory decreased during inspiratory stage while increased during expiratory stage. These changes occurred during anesthesia suggesting that certain suprapontine structures may not be obligatory to induce them.
D'Negri
Carlos E
CE
Instituto de Investigaciones Médicas Alfredo Lanari, Facultad de Medicina, Universidad de Buenos Aires, Argentina. cdnegri@lanari.fmed.uba.ar
Pessolano
Fernando A
FA
De Vito
Eduardo L
EL
D000758:Anesthesia; D000818:Animals; D004285:Dogs; D004548:Elasticity / Q000502:physiology; D005583:Fourier Analysis; D007320:Inspiratory Capacity / Q000502:physiology; D008570:Memory, Short-Term / Q000502:physiology; D015656:Respiratory Mechanics / Q000502:physiology*