Cervical dysplasia in Nigerian women infected with HIV.
OBJECTIVE
To determine the prevalence of and risk factors for cervical dysplasia in HIV-positive women receiving care at the Jos University Teaching Hospital in Nigeria.


METHODS
A total of 369 HIV-positive women had cervical cytology performed; HIV-1 RNA viral load and CD4 counts were measured.


RESULTS
Of 369 participants, cervical dysplasia was present in 107 (29.0%) women. However, cervical cytology was abnormal in 252 (68.3%). Among those with abnormal cytology, 145 (57.5%) women had ASCUS, 56 (22.2%) had LSIL, and 51 (20.2%) had HSIL. Median CD4 lymphocyte count was lower in women with dysplasia compared with those without (142 vs 170 cells/mm(3); P=0.04), while median HIV RNA viral load was higher in women with dysplasia (101781 vs 77479 copies/mL; P=0.002). Low CD4 count (<200 cells/mm(3)) and evidence of HPV infection were significantly associated with cervical dysplasia.


CONCLUSIONS
A high prevalence of cervical dysplasia was found among HIV-positive Nigerian women, which was associated with increased immune suppression.
Agaba
Patricia A
PA
AIDS Prevention Initiative Nigeria Plus, Jos University Teaching Hospital, Jos, Nigeria. ellagaba@yahoo.com
Thacher
Thomas D
TD
Ekwempu
Chinedu C
CC
Idoko
John A
JA
D000328:Adult; D018791:CD4 Lymphocyte Count; D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008875:Middle Aged; D009549:Nigeria / Q000453:epidemiology; D015995:Prevalence; D012367:RNA, Viral / Q000097:blood*; D012307:Risk Factors; D002578:Uterine Cervical Dysplasia / Q000453:epidemiology / Q000821:virology*; D019562:Viral Load; D055815:Young Adult
D012367:RNA, Viral