title: Carcinoma of the uterine cervix with squamous and sebaceous differentiation.
abstract: Sebaceous neoplasms, including carcinoma, can exceptionally arise in extracutaneous sites. We present the third known case of carcinoma with sebaceous differentiation in the uterine cervix. Histologic and immunohistochemical features suggested a metaplastic process within an otherwise usual squamous cell carcinoma. We speculate that, by analogy with the skin where the epidermis and the 3 types of adnexa have a common embryologic origin from basal cell layer of the superficial ectoderm, it is possible that endocervical reserve cells, in addition to the well-known capacity of squamous differentiation, retain the potential to give rise to appendages including sebaceous glands.
authors.affiliation: Department of Pathology of the University of Trieste, Trieste, Italy. crizzardi@units.it
authors.forename: Clara
authors.initials: C
authors.lastname: Rizzardi
authors.forename: Tiziana
authors.initials: T
authors.lastname: Perin
authors.forename: Manuela
authors.initials: M
authors.lastname: Schneider
authors.forename: Diego
authors.initials: D
authors.lastname: Rossi
authors.forename: Alessandro
authors.initials: A
authors.lastname: Brollo
authors.forename: Mauro
authors.initials: M
authors.lastname: Melato
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Canzonieri
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols; D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000473:pathology* / Q000628:therapy; D002454:Cell Differentiation; D003131:Combined Modality Therapy; D017809:Fatal Outcome; D005260:Female; D020275:Guillain-Barre Syndrome / Q000473:pathology; D006526:Hepatitis C / Q000150:complications; D006801:Humans; D007044:Hysterectomy; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D011878:Radiotherapy; D012627:Sebaceous Glands / Q000473:pathology*; D002583:Uterine Cervical Neoplasms / Q000150:complications / Q000473:pathology* / Q000628:therapy