Multiple origins of foot-and-mouth disease virus serotype Asia 1 outbreaks, 2003-2007.
We investigated the molecular epidemiology of foot-and-mouth disease virus (FMDV) serotype Asia 1, which caused outbreaks of disease in Asia during 2003-2007. Since 2004, the region affected by outbreaks of this serotype has increased from disease-endemic countries in southern Asia (Afghanistan, India, Iran, Nepal, Pakistan) northward to encompass Kyrgyzstan, Tajikistan, Uzbekistan, several regions of the People's Republic of China, Mongolia, Eastern Russia, and North Korea. Phylogenetic analysis of complete virus capsid protein 1 (VP1) gene sequences demonstrated that the FMDV isolates responsible for these outbreaks belonged to 6 groups within the Asia 1 serotype. Some contemporary strains were genetically closely related to isolates collected historically from the region as far back as 25 years ago. Our analyses also indicated that some viruses have spread large distances between countries in Asia within a short time.
Valarcher
Jean Francois
JF
Institute for Animal Health, Pirbright, UK.
Knowles
Nick J
NJ
Zakharov
Valery
V
Scherbakov
Alexey
A
Zhang
Zhidong
Z
Shang
You Jun
YJ
Liu
Zai Xin
ZX
Liu
Xiang Tao
XT
Sanyal
Aniket
A
Hemadri
Divakar
D
Tosh
Chakradhar
C
Rasool
Thaha J
TJ
Pattnaik
Bramhadev
B
Schumann
Kate R
KR
Beckham
Tammy R
TR
Linchongsubongkoch
Wilai
W
Ferris
Nigel P
NP
Roeder
Peter L
PL
Paton
David J
DJ
D000346:Afghanistan / Q000453:epidemiology; D000818:Animals; D001208:Asia / Q000453:epidemiology; D002681:China / Q000453:epidemiology; D004279:DNA, Viral / Q000235:genetics; D004196:Disease Outbreaks; D005536:Foot-and-Mouth Disease / Q000453:epidemiology*; D029544:Foot-and-Mouth Disease Virus / Q000145:classification / Q000235:genetics*; D005843:Geography; D006801:Humans; D007194:India / Q000453:epidemiology; D009390:Nepal / Q000453:epidemiology; D010154:Pakistan / Q000453:epidemiology; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012703:Serotyping
D004279:DNA, Viral; D012367:RNA, Viral