title: The anticonvulsant zonisamide reduces ethanol self-administration by risky drinkers.
abstract: OBJECTIVE
  The purpose of this study is to examine the effects of zonisamide on ethanol self-administration and subjective effects in risky drinkers using a human laboratory paradigm.
  
  
  METHODS
  We conducted a double-blind, placebo-controlled study of the effects of zonisamide 100 mg on ethanol self-administration and urge to drink in risky drinkers (N = 10) ( [1] ).
  
  
  RESULTS
  During the second hour of a 2-hour self-administration session ethanol consumption was 50% lower in the zonisamide group as compared to the placebo group. Urge to drink was also significantly lower under the zonisamide condition.
  
  
  CONCLUSIONS
  These results indicate that a single dose of zonisamide reduces urge to drink and the quantity of ethanol self-administered by risky drinkers during their second hour of access to alcohol.
  
  
  CONCLUSIONS
  Zonisamide may help individuals drinking at risky levels reduce their intake of alcohol.
authors.affiliation: Boston University School of Medicine, Massachusetts, USA.
authors.forename: Ofra
authors.initials: O
authors.lastname: Sarid-Segal
authors.forename: Clifford M
authors.initials: CM
authors.lastname: Knapp
authors.forename: William
authors.initials: W
authors.lastname: Burch
authors.forename: Mark A
authors.initials: MA
authors.lastname: Richardson
authors.forename: Sean
authors.initials: S
authors.lastname: Bahtia
authors.forename: Kimberly
authors.initials: K
authors.lastname: DeQuattro
authors.forename: Maryam
authors.initials: M
authors.lastname: Afshar
authors.forename: Courtney
authors.initials: C
authors.lastname: Richambault
authors.forename: Laurie
authors.initials: L
authors.lastname: Sickels
authors.forename: Eric
authors.initials: E
authors.lastname: Devine
authors.forename: Domenic A
authors.initials: DA
authors.lastname: Ciraulo
mesh_terms: D000328:Adult; D000428:Alcohol Drinking / Q000188:drug therapy*; D000927:Anticonvulsants / Q000627:therapeutic use; D018592:Cross-Over Studies; D004311:Double-Blind Method; D000431:Ethanol / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007555:Isoxazoles / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D012646:Self Administration; D011795:Surveys and Questionnaires; D013997:Time Factors; D000078305:Zonisamide
chemical_list: D000927:Anticonvulsants; D007555:Isoxazoles; D000431:Ethanol; D000078305:Zonisamide