Piceamycin and its N-acetylcysteine adduct is produced by Streptomyces sp. GB 4-2.
Piceamycin, a new macrolactam polyketide antibiotic, was detected by HPLC-diode array screening in extracts of Streptomyces sp. GB 4-2, which was isolated from the mycorrhizosphere of Norway spruce. The structure of piceamycin was determined by mass spectrometry and NMR experiments. It showed inhibitory activity against Gram-positive bacteria, selected human tumor cell lines and protein tyrosine phosphatase 1B.
Schulz
Dirk
D
Mikrobiologisches Institut, Universität Tübingen, Tübingen, Germany.
Nachtigall
Jonny
J
Riedlinger
Julia
J
Schneider
Kathrin
K
Poralla
Karl
K
Imhoff
Johannes F
JF
Beil
Winfried
W
Nicholson
Graeme
G
Fiedler
Hans-Peter
HP
Süssmuth
Roderich D
RD
D000111:Acetylcysteine / Q000737:chemistry / Q000378:metabolism*; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006801:Humans; D047029:Lactams, Macrocyclic / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D038821:Mycorrhizae / Q000378:metabolism; D028222:Picea / Q000382:microbiology; D018517:Plant Roots / Q000382:microbiology; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1 / Q000037:antagonists & inhibitors; D011994:Recombinant Proteins / Q000037:antagonists & inhibitors; D013302:Streptomyces / Q000254:growth & development / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D047029:Lactams, Macrocyclic; D011994:Recombinant Proteins; C544881:piceamycin; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1; D000111:Acetylcysteine