title: The complement cascade as a therapeutic target in intracerebral hemorrhage.
abstract: Intracerebral hemorrhage (ICH) is the second most common and deadliest form of stroke. Currently, no pharmacologic treatment strategies exist for this devastating disease. Following the initial mechanical injury suffered at hemorrhage onset, secondary brain injury proceeds through both direct cellular injury and inflammatory cascades, which trigger infiltration of granulocytes and monocytes, activation of microglia, and disruption of the blood-brain barrier with resulting cerebral edema. The complement cascade has been shown to play a central role in the pathogenesis of secondary injury following ICH, although the specific mechanisms responsible for the proximal activation of complement remain incompletely understood. Cerebral injury following cleavage of complement component 3 (C3) proceeds through parallel but interrelated pathways of anaphylatoxin-mediated inflammation and direct toxicity secondary to membrane attack complex-driven erythrocyte lysis. Complement activation also likely plays an important physiologic role in recovery following ICH. As such, a detailed understanding of the variation in functional effects of complement activation over time is critical to exploiting this target as an exciting translational strategy for intracerebral hemorrhage.
authors.affiliation: Department of Neurological Surgery, Columbia University, 630 West 168th Street, New York, NY 10032, USA. afd12@columbia.edu
authors.forename: Andrew F
authors.initials: AF
authors.lastname: Ducruet
authors.forename: Brad E
authors.initials: BE
authors.lastname: Zacharia
authors.forename: Zachary L
authors.initials: ZL
authors.lastname: Hickman
authors.forename: Bartosz T
authors.initials: BT
authors.lastname: Grobelny
authors.forename: Mason L
authors.initials: ML
authors.lastname: Yeh
authors.forename: Sergey A
authors.initials: SA
authors.lastname: Sosunov
authors.forename: E Sander
authors.initials: ES
authors.lastname: Connolly
mesh_terms: D000818:Animals; D002543:Cerebral Hemorrhage / Q000503:physiopathology* / Q000628:therapy*; D003167:Complement Activation / Q000187:drug effects; D003176:Complement C3 / Q000378:metabolism*; D018450:Disease Progression; D006801:Humans; D018836:Inflammation Mediators / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D003176:Complement C3; D018836:Inflammation Mediators