The influence of intraoperative homologous blood transfusion on prognosis after liver transplantation for hepatocellular carcinoma.
OBJECTIVE
We investigated the influence of intraoperative homologous blood transfusion on prognosis after liver transplantation for hepatocellular carcinoma.


METHODS
Between February 1999 and December 2006, 153 patients with hepatocellular carcinoma underwent living donor liver transplantation at our center. Recurrence-free and overall survival was compared between patients with blood transfusion and those without transfusion in red blood cells, fresh frozen plasma, or platelet concentrate.


RESULTS
Recurrence-free survival was significantly higher in the platelet concentrate transfused group than in the group without platelet concentrate transfusion (P=0.003), although there were no significant differences between the three transfused groups and the non-transfused groups in overall survival. The platelet concentrate transfused group had more patients within the preoperative Milan criteria (P=0.014) and more patients with Child-Pugh C classification (P<0.001).


CONCLUSIONS
Recurrence-free survival after liver transplantation for hepatocellular carcinoma was significantly higher in the platelet concentrate transfused group than the group without platelet concentrate transfusion.
Kaido
Toshimi
T
Department of Hepato-Biliary-Pancreatic and Transplant Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan. kaido@kuhp.kyoto-u.ac.jp
Takada
Yasutsugu
Y
Egawa
Hiroto
H
Uemoto
Shinji
S
D000328:Adult; D000368:Aged; D016063:Blood Loss, Surgical; D001803:Blood Transfusion; D006528:Carcinoma, Hepatocellular / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007430:Intraoperative Care; D008113:Liver Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome; D055815:Young Adult