Prophylactic use of isepamicin and levofloxacin for transrectal prostate biopsy: a retrospective single center study.
OBJECTIVE
To evaluate the combination of isepamicin and levofloxacin in the prophylaxis of infectious complications associated with prostate biopsy (PBX).


METHODS
A total of 586 patients who underwent transrectal PBX in a single center were included in this retrospective analysis. They received 400 mg isepamicin once just before PBX plus 300 mg oral levofloxacin each day for three days as a rule. Clinical and laboratory data were evaluated.


RESULTS
A total of three (0.51%) patients presented a febrile complication after PBX. All of them were diagnosed as acute prostatitis. Serum white blood cell count and C-reactive protein in the 131 patients whose laboratory data were available for statistical analyses did not rise significantly after PBX.


CONCLUSIONS
Isepamicin plus fluoroquinolone can be considered a valuable regimen for antibiotic prophylaxis of PBX.
Shigemura
Katsumi
K
Division of Urology, Department of Organs Therapeutics, Faculty of Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan. katsumiatlanta@hotmail.com
Yasufuku
Tomihiko
T
Yamashita
Masuo
M
Arakawa
Soichi
S
Fujisawa
Masato
M
D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D019072:Antibiotic Prophylaxis; D001424:Bacterial Infections / Q000209:etiology / Q000517:prevention & control*; D001706:Biopsy / Q000009:adverse effects; D004359:Drug Therapy, Combination; D005839:Gentamicins / Q000627:therapeutic use; D006801:Humans; D064704:Levofloxacin; D008297:Male; D015242:Ofloxacin / Q000627:therapeutic use*; D011467:Prostate / Q000473:pathology*; D011472:Prostatitis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology; D012007:Rectum; D012189:Retrospective Studies; D012307:Risk Factors; D036761:Ultrasound, High-Intensity Focused, Transrectal
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D064704:Levofloxacin; D015242:Ofloxacin; C016927:isepamicin