Pathogenesis and management of irritable bowel syndrome.
The exact cause of irritable bowel syndrome (IBS) is not known. Multiple factors, like genetic, gut motility, visceral hypersensitivity, psychosocial factors and immune-mediated factors, are thought to contribute to the symptom complex of IBS. Till date an 'IBS gene' has not been defined, and there is a need for further studies. The concept that IBS as a diagnosis of exclusion is not acceptable any more. The treatment of IBS is targeted at the management of constipation, diarrhoea and abdominal pain and includes pharmacotherapy with tegaserod, alosetron and lubiprostone. Cognitive behavioral therapy is very beneficial.
Mathew
Praveen
P
Department of Gastroenterology, Seth GS Medical College and KEM Hospital, Parel, Mumbai, India.
Bhatia
Shobna J
SJ
D000527:Alprostadil / Q000031:analogs & derivatives / Q000627:therapeutic use; D000818:Animals; D000928:Antidepressive Agents / Q000627:therapeutic use; D002243:Carbolines / Q000627:therapeutic use; D004043:Dietary Fiber / Q000627:therapeutic use; D005765:Gastrointestinal Agents / Q000627:therapeutic use; D005769:Gastrointestinal Motility; D006801:Humans; D006930:Hyperalgesia / Q000150:complications; D007211:Indoles / Q000627:therapeutic use; D043183:Irritable Bowel Syndrome / Q000209:etiology* / Q000235:genetics / Q000523:psychology / Q000628:therapy*; D008139:Loperamide / Q000627:therapeutic use; D000068238:Lubiprostone; D010276:Parasympatholytics / Q000627:therapeutic use; D010375:Pedigree; D011613:Psychotherapy; D017366:Serotonin Receptor Agonists / Q000627:therapeutic use; D016896:Treatment Outcome
D000928:Antidepressive Agents; D002243:Carbolines; D004043:Dietary Fiber; D005765:Gastrointestinal Agents; D007211:Indoles; D010276:Parasympatholytics; D017366:Serotonin Receptor Agonists; C090840:alosetron; C105050:tegaserod; D008139:Loperamide; D000068238:Lubiprostone; D000527:Alprostadil