An efficient and economic asymmetric synthesis of (+)-nootkatone, tetrahydronootkatone, and derivatives.
A facile route to enantiomerically pure (+)-nootkatone and derivatives has been established through conjunctive stereoselective Grignard/anionic oxy-Cope (AOC) reactions.
Sauer
Anne M
AM
Department of Chemistry, Louisiana State UniVersityAgricultural Center, Baton Rouge, Louisiana 70803, USA.
Crowe
William E
WE
Henderson
Gregg
G
Laine
Roger A
RA
D002384:Catalysis; D015394:Molecular Structure; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; C484718:tetrahydronootkatone; C050302:nootkatone