title: Role of transporter proteins in bile tolerance of Lactobacillus acidophilus.
abstract: Lactobacillus acidophilus NCFM derivatives containing deletion mutations in the transporter genes LBA0552, LBA1429, LBA1446, and LBA1679 exhibited increased sensitivity to bile. These strains showed unique patterns of sensitivity to a variety of inhibitory compounds, as well as differential accumulations of ciprofloxacin and taurocholate.
authors.affiliation: Genomic Sciences Graduate Program, Department of Food, Bioprocessing, & Nutrition Sciences, North Carolina State University, Raleigh, NC 27695, USA.
authors.forename: Erika A
authors.initials: EA
authors.lastname: Pfeiler
authors.forename: Todd R
authors.initials: TR
authors.lastname: Klaenhammer
mesh_terms: D000900:Anti-Bacterial Agents / Q000378:metabolism / Q000494:pharmacology*; D001646:Bile / Q000737:chemistry* / Q000378:metabolism; D002939:Ciprofloxacin / Q000378:metabolism / Q000494:pharmacology; D003902:Detergents / Q000378:metabolism / Q000494:pharmacology*; D017353:Gene Deletion; D005798:Genes, Bacterial; D007779:Lactobacillus acidophilus / Q000187:drug effects* / Q000502:physiology*; D026901:Membrane Transport Proteins / Q000235:genetics / Q000378:metabolism*; D050296:Microbial Viability; D013656:Taurocholic Acid / Q000378:metabolism / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D003902:Detergents; D026901:Membrane Transport Proteins; D013656:Taurocholic Acid; D002939:Ciprofloxacin