The relationship between chronic hepatitis B infection and bone mineral, metabolism in peritoneal dialysis patients.
OBJECTIVE
Abnormality of bone mineral metabolism is a common complication in chronic liver disease and/or chronic renal disease patients. We designed this study to evaluate the relationship between chronic hepatitis B infection and bone mineral metabolism in peritoneal dialysis patients.


METHODS
Serum calcium[adj], phosphorus, calcium and phosphorus product (Ca x P), along with intact parathyroid hormone (iPTH) levels were compared in peritoneal dialysis patients with and without chronic hepatitis B infection.


RESULTS
A total of 220 patients (142 female, 78 male) with a mean age of 56.30 +/- 14.28 (range 19 - 86) years old were recruited, 23 showed chronic hepatitis B infection and 197 showed none. No statistically significant difference in serum calcium[adj] levels (9.90 +/- 0.85 mg/dl vs. 10.08 +/- 0.80 mg/dl, p = 0.354), phosphorus levels (5.26 +/- 1.58 mg/dl vs. 5.21 +/- 1.35 mg/dl, p = 0.879) and calcium and phosphorus product (Ca x P) (52.23 +/- 17.54 mg(2)/dl(2) vs. 52.42 +/- 14.16 mg(2)/dl(2), p = 0.960) between groups with and without chronic hepatitis B infection was observed. Serum iPTH levels were significantly lower in chronic hepatitis B patients (median 143 pg/ml, range 3.42 - 889) than in the control group (median 235 pg/ml, range 3 - 2381) (p = 0.035). As analyzed by multi-variable linear regression, chronic hepatitis B was a predictor of lower serum iPTH levels (beta = -0.271; p = 0.030) after adjustments for age, gender, serum calcium and phosphorus levels and diabetes.


CONCLUSIONS
No significant difference in serum calcium[adj]), phosphorus and calcium and phosphorus product (Ca x P) levels appeared between peritoneal dialysis patients with and without chronic hepatitis B infection. Serum iPTH levels proved to be definitely lower in chronic hepatitis B infection patients.
Liu
Y-L
YL
Division of Nephrology and Kidney Institute, Department of Medicine, China Medical University Hospital, China.
Wang
S-M
SM
Lin
H-H
HH
Wang
I-K
IK
Kuo
H-L
HL
Yang
Y-F
YF
Liu
J-H
JH
Chou
C-Y
CY
Yeh
H-C
HC
Ting
I-W
IW
Tsai
C-A
CA
Huang
C-C
CC
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015519:Bone Density; D001842:Bone and Bones / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism; D016009:Chi-Square Distribution; D005260:Female; D019694:Hepatitis B, Chronic / Q000150:complications*; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000378:metabolism; D010530:Peritoneal Dialysis; D010758:Phosphorus / Q000378:metabolism; D018709:Statistics, Nonparametric
D010281:Parathyroid Hormone; D010758:Phosphorus; D002118:Calcium