title: Perfusion computed tomography for monitoring induction chemotherapy in patients with squamous cell carcinoma of the upper aerodigestive tract: correlation between changes in tumor perfusion and tumor volume.
abstract: OBJECTIVE
  The aim of this study was to assess the potential of perfusion computed tomography (CTp) for monitoring induction chemotherapy in patients with squamous cell carcinoma (SCCA) of the upper aerodigestive tract.
  
  
  METHODS
  Twenty-five patients with advanced SCCA underwent CTp and volumetric CT before and after induction chemotherapy. Perfusion CT parameters were calculated in the tumor, normal tissue, and muscles and correlated with tumor volume.
  
  
  RESULTS
  The blood flow (BF), blood volume (BV), and permeability surface were significantly higher, and the mean transit time was significantly lower in the tumor than in the normal tissue. The tumor BF and BV significantly decreased, and the mean transit time significantly increased after the therapy; decrease in BF and BV correlated with tumor volume reduction after chemotherapy. The baseline tumor BV was significantly lower in nonresponders compared with that in responders.
  
  
  CONCLUSIONS
  In patients with SCCA, CTp showed potential for monitoring induction chemotherapy, reduction in tumor BF and BV correlated with reduction of tumor volume after chemotherapy, and baseline tumor BV may predict response to chemotherapy.
authors.affiliation: Department of Radiology, European Institute of Oncology, Milan, Italy. giuseppe.petralia@ieo.it
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Petralia
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Preda
authors.forename: Gioacchino
authors.initials: G
authors.lastname: Giugliano
authors.forename: Barbara A
authors.initials: BA
authors.lastname: Jereczek-Fossa
authors.forename: Andrea
authors.initials: A
authors.lastname: Rocca
authors.forename: Gabriele
authors.initials: G
authors.lastname: D'Andrea
authors.forename: Nagaraj Setty
authors.initials: NS
authors.lastname: Holalkere
authors.forename: Fausto
authors.initials: F
authors.lastname: Chiesa
authors.forename: Massimo
authors.initials: M
authors.lastname: Bellomi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001810:Blood Volume; D002199:Capillary Permeability; D002294:Carcinoma, Squamous Cell / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000188:drug therapy* / Q000473:pathology; D054893:Cone-Beam Computed Tomography / Q000379:methods*; D003287:Contrast Media; D006258:Head and Neck Neoplasms / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008297:Male; D008875:Middle Aged; D055420:Perfusion Imaging / Q000379:methods*; D011856:Radiographic Image Enhancement / Q000379:methods; D012039:Regional Blood Flow; D015203:Reproducibility of Results; D047368:Tumor Burden
chemical_list: D003287:Contrast Media