The influence of pendant hydroxyl groups on enzymatic degradation and drug delivery of amphiphilic poly[glycidol-block-(epsilon-caprolactone)] copolymers.
An amphiphilic diblock copolymer PG-b-PCL with well-controlled structure and pendant hydroxyl groups along hydrophilic block was synthesized by sequential anionic ring-opening polymerization. The micellization and drug release of PG-b-PCL copolymers using pyrene as a fluorescence probe were investigated for determining the influences of copolymer composition and lipase concentration on drug loading capacity and controlled release behavior. The biodegradation of PG-b-PCL copolymers was studied with microspheres as research samples. It has been concluded that the polar hydroxyl groups along each repeat unit of hydrophilic PG block in PG-b-PCL copolymer have great influences on drug encapsulation, drug release, and enzymatic degradation of micelles and microspheres.
Mao
Jing
J
The CAS Key Laboratory of Engineering Plastics, Institute of Chemistry, Chinese Academy of Sciences (CAS), Beijing 100190, China.
Gan
Zhihua
Z
D001672:Biocompatible Materials / Q000737:chemistry / Q000378:metabolism; D002208:Caproates / Q000737:chemistry / Q000378:metabolism; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D016503:Drug Delivery Systems; D004852:Epoxy Compounds / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D007783:Lactones / Q000737:chemistry / Q000378:metabolism; D008422:Materials Testing; D008863:Microspheres; D015394:Molecular Structure; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D020005:Propanols / Q000737:chemistry / Q000378:metabolism; D013499:Surface Properties
D001672:Biocompatible Materials; D002208:Caproates; D004337:Drug Carriers; D004852:Epoxy Compounds; D007783:Lactones; D011108:Polymers; D020005:Propanols; C121056:caprolactone; C004312:glycidol