title: Preliminary results from a prospective study using limited margin radiotherapy in pediatric and young adult patients with high-grade nonrhabdomyosarcoma soft-tissue sarcoma.
abstract: OBJECTIVE
  To demonstrate the safety and efficacy of limited margin radiotherapy in the local control of pediatric and young adult patients with high-grade nonrhabdomyosarcoma soft tissue sarcoma (NRSTS).
  
  
  METHODS
  Pediatric patients with high-grade NRSTS requiring radiation were treated on an institutional review board approved prospective institutional study of conformal/intensity-modulated/interstitial brachytherapy using a 2-cm anatomically constrained margin.
  
  
  RESULTS
  A total of 32 patients (median age, 15.3 years; range, 2-22 years) received adjuvant (27 patients) or definitive (5 patients) irradiation. With a median follow-up of 32 months, the 3-year cumulative incidence of local failure was 3.7% for patients undergoing irradiation after surgical resection. Four patients experienced local failure; the mean dose to the volume of recurrence was >or=97% of the prescribed dose.
  
  
  CONCLUSIONS
  Delivery of limited margin radiotherapy using external beam or brachytherapy provides a high rate of local tumor control without marginal failure. Further follow-up is required to determine whether normal tissue effects are minimized using this approach.
authors.affiliation: Department of Radiological Sciences, St Jude Children's Research Hospital, Memphis, TN 38105, USA. matthew.krasin@stjude.org
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Krasin
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Davidoff
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Xiong
authors.forename: Shengjie
authors.initials: S
authors.lastname: Wu
authors.forename: Chia-Ho
authors.initials: CH
authors.lastname: Hua
authors.forename: Fariba
authors.initials: F
authors.lastname: Navid
authors.forename: Carlos
authors.initials: C
authors.lastname: Rodriguez-Galindo
authors.forename: Bhaskar N
authors.initials: BN
authors.lastname: Rao
authors.forename: Kelly A
authors.initials: KA
authors.lastname: Hoth
authors.forename: Michael D
authors.initials: MD
authors.lastname: Neel
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Merchant
authors.forename: Larry E
authors.initials: LE
authors.lastname: Kun
authors.forename: Sheri L
authors.initials: SL
authors.lastname: Spunt
mesh_terms: D000293:Adolescent; D001918:Brachytherapy / Q000009:adverse effects / Q000379:methods*; D002648:Child; D002675:Child, Preschool; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D011446:Prospective Studies; D011879:Radiotherapy Dosage; D018714:Radiotherapy, Adjuvant; D020266:Radiotherapy, Conformal / Q000009:adverse effects / Q000379:methods*; D050397:Radiotherapy, Intensity-Modulated / Q000009:adverse effects / Q000379:methods; D012509:Sarcoma / Q000473:pathology / Q000532:radiotherapy*; D017211:Treatment Failure; D047368:Tumor Burden; D055815:Young Adult