Solid-phase synthesis and DNA binding studies of dichloroplatinum(ii) conjugates of dicarba analogues of octreotide as new anticancer drugs.
The first dichloroplatinum(ii) conjugates of dicarba analogues of octreotide, which is expected to act as a 'tumour-targeting device', have been efficiently synthesized following a stepwise solid-phase approach; these compounds emulate the mechanism of cisplatin since they form a 1,2-intrastrand cross-link with two consecutive guanines of an oligonucleotide.
Barragán
Flavia
F
Departament de Química Orgànica-IBUB, Universitat de Barcelona, Barcelona, E-08028, Spain.
Moreno
Virtudes
V
Marchán
Vicente
V
D018931:Antineoplastic Agents, Hormonal / Q000737:chemistry*; D001665:Binding Sites; D002713:Chlorine; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D003996:Dicamba / Q000031:analogs & derivatives* / Q000737:chemistry; D006801:Humans; D015282:Octreotide / Q000138:chemical synthesis* / Q000737:chemistry*; D009944:Organoplatinum Compounds / Q000138:chemical synthesis* / Q000737:chemistry
D018931:Antineoplastic Agents, Hormonal; D009944:Organoplatinum Compounds; D002713:Chlorine; D004247:DNA; D015282:Octreotide; D003996:Dicamba