Corn extracts lower tissue arsenic level in rat.
This study was carried out to see whether corn extracts could reduce the accumulation of arsenic in different tissues of rat. Exposure to arsenic (700 microg/rat/day) orally for 15 days led to significant accumulation of arsenic and significant reduction in the concentration of reduced glutathione (GSH) in different tissues. While water, salt, ethanol and alkali extracts of corn were co-administered at a dose of 0.5 mL/rat/day orally by stomach tube during last 8 days, arsenic concentration decreased significantly in all tissues and reduced glutathione (GSH) concentration increased significantly in tissues except heart and skin. Among the extracts, water extract produced maximum reduction of arsenic (69.07% in liver, 64.98% in kidney, 63.47% in lung, 57.55% in heart and 69.30% in skin) and elevation of reduced glutathione level in all tissues (17.03% in liver, 46.73% in lung, 32.67% in heart and 55.38% in skin) except kidney, in which maximum elevation of reduced glutathione was attained by ethanol extract (23.14%). This study suggests that corn extracts might protect rats from accumulation of arsenic in different tissues and oxidative stress, which is reflected by the increasing reduced glutathione concentration in those tissues.
Chowdhury
Noor Jahan Alam
NJ
Division of Arsenic Research, Department of Pharmacology, Faculty of Basic Medical Sciences, Bangabnadhu Sheikh Mujib Medical University, Shahbag, Dhaka, Bangladesh.
Misbahuddin
Mir
M
Rahman
Md Sayedur
MS
D000704:Analysis of Variance; D000818:Animals; D020261:Arsenic Poisoning / Q000188:drug therapy*; D005978:Glutathione / Q000187:drug effects; D006321:Heart / Q000187:drug effects; D007668:Kidney / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D008168:Lung / Q000187:drug effects; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D018514:Plant Structures; D051381:Rats; D020318:Rats, Long-Evans; D012867:Skin / Q000187:drug effects; D003313:Zea mays
D010936:Plant Extracts; D005978:Glutathione