title: Impact of allogeneic 2-RBC apheresis on iron stores of Brazilian blood donors.
abstract: One limiting factor for automated two-red blood cells collections (2-RBC) is its potential iron depletion. We analyzed hematological parameters and iron balance before, two and four months after 2-RBC of 96 non-supplemented male donors. Four months after 2-RBC, ferritin level was significantly lower (P<0.01) than baseline levels and the number of donors who presented ferritin <30 ng/ml increased from 18 to 47. We concluded that four months was not sufficient for iron recuperation in the population studied. In an attempt to avoid iron depletion after 2-RBC, we recommend augmentation in the interval between blood donations and pre-donation ferritin measurement.
authors.affiliation: Fundação Pró-Sangue/Hemocentro de São Paulo, Av. Dr. Enéas de Carvalho Aguiar, Cerqueira Cesar, 05403-000 São Paulo, SP, Brazil. alfredo.mendrone@usp.br
authors.forename: Alfredo
authors.initials: A
authors.lastname: Mendrone
authors.forename: Cyntia Araújo
authors.initials: CA
authors.lastname: Arrais
authors.forename: César
authors.initials: C
authors.lastname: Almeida Neto
authors.forename: Sandra de Fátima Menocci
authors.initials: Sde F
authors.lastname: Gualandro
authors.forename: Pedro Enrique
authors.initials: PE
authors.lastname: Dorlhiac-Llacer
authors.forename: Dalton de Alencar Fischer
authors.initials: Dde A
authors.lastname: Chamone
authors.forename: Ester Cerdeira
authors.initials: EC
authors.lastname: Sabino
mesh_terms: D000293:Adolescent; D000328:Adult; D001781:Blood Component Removal / Q000379:methods*; D001782:Blood Donors; D001938:Brazil; D017707:Erythrocyte Transfusion; D004912:Erythrocytes / Q000502:physiology*; D005293:Ferritins / Q000378:metabolism; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007501:Iron / Q000097:blood*; D008297:Male; D008875:Middle Aged; D014168:Transferrin / Q000378:metabolism; D055815:Young Adult
chemical_list: D006454:Hemoglobins; D014168:Transferrin; D005293:Ferritins; D007501:Iron