Consolidation of an extinction memory depends on the unconditioned stimulus magnitude previously experienced during training.
Here, we examine the role of the magnitude of the unconditioned stimulus (US) during classical conditioning in consolidation processes after memory retrieval. We varied the US durations during training and we test the impact of these variations on consolidation after memory retrieval with one or two conditioned stimulus-only trials. We found that the consolidation of an extinction memory depends on US duration during training and ruled out the possibility that this effect is attributable to differences in satiation after conditioning. We conclude that consolidation of an extinction memory is triggered only when the duration of the US reaches a critical threshold. This demonstrates that memory consolidation cannot be regarded as an isolated process depending solely on training conditions. Instead, it depends on the animal's previous experience as well.
Stollhoff
Nicola
N
Freie Universität Berlin, Department of Biology/Chemistry/Pharmacy, Institute for Biology, Neurobiology, 14195 Berlin, Germany.
Eisenhardt
Dorothea
D
D000818:Animals; D001245:Association Learning / Q000187:drug effects / Q000502:physiology; D001516:Bees; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology*; D004640:Emetine / Q000008:administration & dosage; D005108:Extinction, Psychological / Q000187:drug effects / Q000502:physiology*; D008568:Memory / Q000187:drug effects / Q000502:physiology*; D009812:Odorants; D011500:Protein Synthesis Inhibitors / Q000008:administration & dosage; D012527:Satiation / Q000502:physiology; D013997:Time Factors
D011500:Protein Synthesis Inhibitors; D004640:Emetine