Arterial stiffness in mild-to-moderate CKD.
Whether arterial stiffness correlates with mild-to-moderate CKD and albuminuria in the community is unclear. We studied the association between arterial stiffness and mild-to-moderate CKD and albuminuria in the Framingham Heart Study. CKD was present in 6.7% (181 of 2682) of participants and microalbuminuria was present in 8.2% (479 of 5818). The measures of arterial stiffness were the carotid femoral pulse wave velocity, forward pressure wave amplitude, central pulse pressure, augmentation pressure, augmentation index, and mean arterial pressure. In cross-sectional analyses, arterial stiffness did not associate with CKD (defined by estimated GFR <60 ml/min/1.73 m(2)) in either age- and gender-adjusted or multivariable-adjusted linear regression models. Carotid femoral pulse wave velocity associated with both urinary albumin-to-creatinine ratio and microalbuminuria (P < 0.0001 after multivariable adjustment). In longitudinal analyses, we used logistic regression models to examine the associations between baseline arterial stiffness measures (exposure variables) and incident CKD or microalbuminuria (n = 1675 for CKD analyses and n = 1252 for microalbuminuria analyses). Baseline arterial measures did not associate with incident CKD or incident microalbuminuria. In summary, arterial stiffness correlates with albuminuria but not with mild-to-moderate CKD.
Upadhyay
Ashish
A
Renal Section, Boston Medical Center and Boston University School of Medicine, Boston, Massachusetts, USA.
Hwang
Shih-Jen
SJ
Mitchell
Gary F
GF
Vasan
Ramachandran S
RS
Vita
Joseph A
JA
Stantchev
Plamen I
PI
Meigs
James B
JB
Larson
Martin G
MG
Levy
Daniel
D
Benjamin
Emelia J
EJ
Fox
Caroline S
CS
D000328:Adult; D000368:Aged; D000419:Albuminuria / Q000453:epidemiology* / Q000503:physiopathology; D001783:Blood Flow Velocity; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000503:physiopathology; D002339:Carotid Arteries / Q000503:physiopathology; D005260:Female; D005263:Femoral Artery / Q000503:physiopathology; D005919:Glomerular Filtration Rate; D006801:Humans; D015994:Incidence; D007668:Kidney / Q000502:physiology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011673:Pulsatile Flow; D051436:Renal Insufficiency, Chronic / Q000453:epidemiology* / Q000503:physiopathology; D012720:Severity of Illness Index