Giant subcortical heterotopia involving the temporo-parieto-occipital region: a challenging cause of drug-resistant epilepsy.
The clinical, radiological, neurophysiological and neuropsychological findings of three patients with giant subcortical heterotopia are reported. All patients experienced psychomotor and behaviour improvement after surgery. Two subjects are seizure-free after complete excision of the heterotopia; the third patient significantly improved following subtotal removal (Engel's class II). Patients affected by giant subcortical heterotopias can have a favourable prognosis after the surgical removal of the malformation, even following long-lasting epilepsy.
Novegno
Federica
F
Department of Pediatric Neurosurgery, Catholic University Medical School, Largo A. Gemelli, 8, 00168 Rome, Italy. federicanovegno@hotmail.it
Battaglia
Domenica
D
Chieffo
Daniela
D
Frassanito
Paolo
P
Leoni
Chiara
C
Tamburrini
Gianpiero
G
Massimi
Luca
L
Tartaglione
Tommaso
T
Di Rocco
Concezio
C
Guzzetta
Francesco
F
D000293:Adolescent; D001931:Brain Mapping; D002675:Child, Preschool; D054221:Classical Lissencephalies and Subcortical Band Heterotopias / Q000503:physiopathology / Q000601:surgery*; D004569:Electroencephalography; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests; D009778:Occipital Lobe / Q000503:physiopathology; D010296:Parietal Lobe / Q000503:physiopathology; D012640:Seizures / Q000503:physiopathology / Q000601:surgery*; D013702:Temporal Lobe / Q000503:physiopathology; D016896:Treatment Outcome