Convenient synthesis of Ibuprofen and naproxen aminoacyl, dipeptidoyl and ester derivatives.
DL-Ibuprofen and L-naproxen were coupled with amino acids and other bioactive compounds to provide ibuprofen and naproxen bioconjugates in 61-95% yield as prodrugs or potential drug candidates.
Katritzky
Alan R
AR
Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA. katritzky@chem.ufl.edu
Jishkariani
Davit
D
Narindoshvili
Tamari
T
D000596:Amino Acids / Q000737:chemistry; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000737:chemistry; D004151:Dipeptides / Q000737:chemistry; D004952:Esters; D007052:Ibuprofen / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D009288:Naproxen / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D011355:Prodrugs / Q000138:chemical synthesis* / Q000737:chemistry; D013265:Stigmasterol / Q000737:chemistry
D000596:Amino Acids; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004151:Dipeptides; D004952:Esters; D011355:Prodrugs; D009288:Naproxen; D013265:Stigmasterol; D007052:Ibuprofen