Aromatic cyclic peroxides and related keto-compounds from the Plakortis sp. component of a sponge consortium.
Six unreported aromatic compounds, 1-6, were isolated, along with the known compounds dehydrocurcuphenol and manoalide, from a sample of Plakortis sp., which was the main component of a Pacific sponge consortium. The new molecules were chemically characterized by spectroscopic methods. Compounds 1-4 contain a six-membered cyclic peroxide, whereas 5 and 6 display a terminal methyl ketone. The new metabolites were tested for antifungal and antibacterial properties. Compounds 1 and 4 were weakly active against S. aureus.
Manzo
Emiliano
E
Istituto di Chimica Biomolecolare, CNR, Via Campi Flegrei 34, I 80078-Pozzuoli (Naples), Italy. emanzo@icmib.na.cnr.it
Ciavatta
M Letizia
ML
Melck
Dominique
D
Schupp
Peter
P
de Voogd
Nicole
N
Gavagnin
Margherita
M
D000818:Animals; D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology; D003500:Cyclization; D004146:Dioxanes / Q000737:chemistry / Q000302:isolation & purification*; D006801:Humans; D007659:Ketones / Q000737:chemistry / Q000302:isolation & purification*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010545:Peroxides / Q000737:chemistry / Q000302:isolation & purification*; D011161:Porifera / Q000737:chemistry*; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification
D000935:Antifungal Agents; D004146:Dioxanes; D007659:Ketones; D010545:Peroxides; D013729:Terpenes; C045673:manoalide