Gingkoselect alleviates chronic corticosterone-induced spatial memory deficits in rats.
The preventive effects of Gingkoselect (100 mg/kg/day, orally, 21 days) on spatial memory deficits induced by a chronic restraint stress (2 h daily, 21 days) or chronic corticosterone treatment (5 mg/kg, subcutaneously, 21 days) were investigated using the Barnes maze. Chronic corticosterone, but not chronic stress, impaired spatial memory, as shown by increased latency to finding escape tunnel in the maze. Gingkoselect normalized cognitive deficits in rats chronically treated with corticosterone, and improved memory above the control levels in the chronically stressed rats.
Walesiuk
Anna
A
Department of Clinical Pharmacology, Medical University of Bialystok, Waszyngtona 15A, 15-274 Bialystok, Poland.
Braszko
Jan J
JJ
D000818:Animals; D002908:Chronic Disease; D003345:Corticosterone; D004353:Drug Evaluation, Preclinical; D020441:Ginkgo biloba; D008297:Male; D008569:Memory Disorders / Q000139:chemically induced / Q000188:drug therapy*; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D013315:Stress, Psychological / Q000150:complications*
D010936:Plant Extracts; D003345:Corticosterone