Induced sputum: a window to lung pathology.
Sputum is recognized as a sampling method for the monitoring and assessment of chronic lung diseases such as asthma, COPD (chronic obstructive pulmonary disease) and cystic fibrosis. Sputum samples the central airways and its protein components (e.g. mucins and cytokines), cellular components (e.g. eosinophils and neutrophils) and microbiological components (e.g. viruses and bacteria) can be used as markers of disease severity, exacerbation, susceptibility or progression. This paper describes the basic constituents of induced sputum and how these influence the quantification and identification of novel biomarkers of chronic lung diseases using techniques such as proteomics.
Nicholas
Ben
B
Division of Infection, Inflammation and Immunity, University of Southampton School of Medicine, Southampton SO16 6YD, UK. bln1@soton.ac.uk
Djukanović
Ratko
R
D015415:Biomarkers / Q000032:analysis; D006801:Humans; D008171:Lung Diseases / Q000378:metabolism*; D009077:Mucins / Q000378:metabolism; D040901:Proteomics / Q000379:methods; D013183:Sputum / Q000737:chemistry / Q000378:metabolism*
D015415:Biomarkers; D009077:Mucins