The influence of parathyroid hormone on the adult hematopoietic stem cell niche.
Adult hematopoietic stem cells (HSCs) reside in the bone marrow in stable microenvironments known as the stem cell niche. One key component of the stem cell niche is cells of the osteoblastic lineage. Factors that are known to affect osteoblast activity, such as parathyroid hormone (PTH), have also been shown to affect the HSCs. Treatment of mice with PTH has led to beneficial effects on the HSC pool, which have led to clinical trials of PTH treatment to enhance HSC-based therapies.
Rashidi
Narges
N
Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at University of Southern California, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Adams
Gregor B
GB
D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000502:physiology; D006801:Humans; D023421:Models, Animal; D010006:Osteoblasts / Q000166:cytology / Q000502:physiology; D010281:Parathyroid Hormone / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D055153:Stem Cell Niche / Q000166:cytology* / Q000502:physiology; D033581:Stem Cell Transplantation
D010281:Parathyroid Hormone