Salivary diagnostics.
The ability to monitor health status, disease onset and progression, and treatment outcome through non-invasive means is a most desirable goal in the health care promotion and delivery. There are three prerequisites to materialize this goal: specific biomarkers associated with a health or disease state; a non-invasive approach to detect and monitor the biomarkers; and the technologies to discriminate the biomarkers. A national initiative catalyzed by the National Institute of Dental & Craniofacial Research (NIDCR) has created a roadmap to achieve these goals through the use of oral fluids as the diagnostic medium to scrutinize the health and/or disease status of individuals. Progress has shown this is an ideal opportunity to bridge state of the art saliva-based biosensors, optimized to disease discriminatory salivary biomarkers, for diagnostic applications. Oral fluid being the 'mirror of body' is a perfect medium to be explored for health and disease surveillance. The translational applications and opportunities are enormous.
Lee
J M
JM
UCLA Lung Cancer Research Program, Division of Cardiothoracic Surgery, University of California Los Angeles, Los Angeles, CA 90095, USA.
Garon
E
E
Wong
D T
DT
D015415:Biomarkers / Q000032:analysis*; D018450:Disease Progression; D006304:Health Status; D006801:Humans; D007202:Indicators and Reagents; D020543:Proteome / Q000032:analysis; D012463:Saliva / Q000737:chemistry*; D012471:Salivary Proteins and Peptides / Q000032:analysis*; D013674:Technology, Dental; D016896:Treatment Outcome
D015415:Biomarkers; D007202:Indicators and Reagents; D020543:Proteome; D012471:Salivary Proteins and Peptides