[Effect of tripterysium glucosides on diabetic cardiomyopathy in rats].
OBJECTIVE
To observe the effect of heart protection on diabetic cardiomyopathy in rats by tripterysium glucosides.


METHODS
The rat diabetic cardiomyopathy rats model are made by streptozotocin, then divided into tripterysium glucosides group (n=8) and model group (n=8). In addition, the control group is established (n=8). Glucosides group was orally administrated tripterysium glucosides (18 mg x kg(-1)), the control groups was orally administrated same volume NS for 3 months. Blood sugar, heart function and cardiac index were detected after 3 months. Immunohistochemical techniques were used to detect NF-kappaB and ICAM-1 expression. Ultrastructure of cardiac muscle cell were observed by electronmicroscope.


RESULTS
Compared with model group, cardiac index was decreased after tripterysium glucosides administration, and LVSP, LVEDP, + dp/dtmax, -dp/dtmax, were improved, and the expression of nuclear Factor-kappaB (NF-kappaB) and intercellular adhension molecule-1 (ICAM-1) was inhibited. Ultrastructure of cardiac muscle cell such as mitochondrion and cardiac muscle fibers was atttenuated.


CONCLUSIONS
Tripterysium glucosides could protect rat diabetic cardiomyopathy rats heart. These function may be related to inflammatory reaction inhibition and immunosuppression of tripterysium glucosides.
Tang
Mingxiang
M
Peoples Hospital of Hunan, Changsha 400003, China.
Guo
Yin
Y
Zhou
Yulu
Y
Wu
Guoling
G
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D009202:Cardiomyopathies / Q000209:etiology* / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D003921:Diabetes Mellitus, Experimental / Q000150:complications*; D005786:Gene Expression Regulation / Q000187:drug effects; D005960:Glucosides / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D006321:Heart / Q000187:drug effects; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000648:ultrastructure; D016328:NF-kappa B / Q000378:metabolism; D051381:Rats
D001786:Blood Glucose; D005960:Glucosides; D016328:NF-kappa B; D018799:Intercellular Adhesion Molecule-1