title: Imaging of tumor angiogenesis: functional or targeted?
abstract: OBJECTIVE
  Angiogenesis--the growth of new vessels--is both a normal physiologic response and a critical step in many pathologic processes, particularly cancer. Imaging has long relied on the different enhancement characteristics of cancer compared with normal tissue; the information generated is often primarily morphologic and qualitative. However, more quantitative methods based on functional and targeted imaging have recently emerged.
  
  
  CONCLUSIONS
  In this article, we review both functional and targeted imaging techniques for assessing tumor angiogenesis.
authors.affiliation: Molecular Imaging Program, National Cancer Institute, National Institutes of Health, 10 Center Dr., MSC 1182, Bldg. 10, Rm. 1B40, Bethesda, MD 20892-1088, USA.
authors.forename: Baris
authors.initials: B
authors.lastname: Turkbey
authors.forename: Hisataka
authors.initials: H
authors.lastname: Kobayashi
authors.forename: Mikako
authors.initials: M
authors.lastname: Ogawa
authors.forename: Marcelino
authors.initials: M
authors.lastname: Bernardo
authors.forename: Peter L
authors.initials: PL
authors.lastname: Choyke
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis*; D045744:Cell Line, Tumor; D003952:Diagnostic Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D008207:Lymphatic Metastasis / Q000175:diagnosis; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000098:blood supply*; D009389:Neovascularization, Pathologic / Q000175:diagnosis*; D049268:Positron-Emission Tomography / Q000379:methods; D014057:Tomography, X-Ray Computed / Q000379:methods; D014463:Ultrasonography / Q000379:methods
chemical_list: D014408:Biomarkers, Tumor