title: Four-dimensional visualization of thoracic blood flow by magnetic resonance imaging in a patient following correction of transposition of the great arteries (d-TGA) and uncorrected aortic coarctation.
abstract: Recent advances in flow-sensitive magnetic resonance imaging (MRI) and data analysis allow for comprehensive noninvasive three-dimensional (3D) visualization of complex blood flow. Electrocardiogram (ECG)-gated three-directional (3dir) flow measurements were employed to assess and visualize time-resolved 3D blood flow in the pulmonary arteries (PA) and thoracic aorta. We present findings in a juvenile patient with surgically corrected transposition of the great arteries (d-TGA) and aortic coarctation. For the first time, the complex flow patterns in the PA following d-TGA were visualized. Morphologically, a slight asymmetry of the PA was found, with considerable impact on vascular hemodynamics, resulting in diastolic retrograde flow in the larger vessel and diastolic filling of the smaller PA. Additionally, increased flow to the supraaortic vessels was found due to aortic coarctation.
authors.affiliation: German Cancer Research Center (DKFZ) Heidelberg, Radiology (E010), Heidelberg, Germany. julia.leyzaporozhan@gmail.com
authors.forename: J
authors.initials: J
authors.lastname: Ley-Zaporozhan
authors.forename: R
authors.initials: R
authors.lastname: Unterhinninghofen
authors.forename: F
authors.initials: F
authors.lastname: Rengier
authors.forename: M
authors.initials: M
authors.lastname: Markl
authors.forename: J
authors.initials: J
authors.lastname: Eichhorn
authors.forename: H
authors.initials: H
authors.lastname: von Tengg-Kobligk
authors.forename: S
authors.initials: S
authors.lastname: Ley
mesh_terms: D000293:Adolescent; D001013:Aorta, Thoracic / Q000503:physiopathology; D001783:Blood Flow Velocity; D004562:Electrocardiography; D006801:Humans; D021621:Imaging, Three-Dimensional; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods*; D008297:Male; D011651:Pulmonary Artery / Q000503:physiopathology; D014188:Transposition of Great Vessels / Q000503:physiopathology* / Q000601:surgery