title: Globulixanthone F, a new polyoxygenated xanthone with an isoprenoid group and two antimicrobial biflavonoids from the stem bark of Symphonia globulifera.
abstract: Bioassay-guided fractionation of the stem bark of Symphonia globulifera has yielded three known xanthones, ugaxanthone (1), mbarraxanthone (2) and gentisein (3), two biflavonoid derivatives named GB2 (4) and manniflavanone GB3 (5), and one new polyoxygenated xanthone with an isoprenoid group, named globulixanthone F (6). The structures of these compounds were elucidated by means of spectroscopic methods. The spectral data of 1 and 2 are reported here for the first time, as well as the antimicrobial activity of globulixanthone F against a range of microorganisms. We also report the total synthesis of the xanthone skeleton.
authors.affiliation: Department of Organic Chemistry, Faculty of Science, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon. mpierrendi@yahoo.fr
authors.forename: Pierre
authors.initials: P
authors.lastname: Mkounga
authors.forename: Zacharias T
authors.initials: ZT
authors.lastname: Fomum
authors.forename: Michèle
authors.initials: M
authors.lastname: Meyer
authors.forename: Bernard
authors.initials: B
authors.lastname: Bodo
authors.forename: Augustin E
authors.initials: AE
authors.lastname: Nkengfack
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D028084:Clusiaceae / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D008967:Molecular Biology; D024301:Plant Bark / Q000737:chemistry*; D044004:Xanthones / Q000737:chemistry*
chemical_list: D000890:Anti-Infective Agents; D005419:Flavonoids; D044004:Xanthones; C543281:globulixanthone F