title: Practical applications of genomics research for treatment of aging skin.
abstract: Skin aging integrates the impact of extrinsic skin insults (e.g., ultraviolet [UV] light, etc.) with chronological, genetically programmed decreases in cellular function. A genomic study of aged skin highlighted the mechanistic importance of skin barrier function, exfoliation, control of reactive oxygen species and maintenance of extracellular matrix to the aging process. A set of topical products designed to address these mechanistic themes was developed and clinically tested. The individual products improved skin barrier function, hydration and skin turnover, as well as the smoothness and depth of periorbital wrinkles. Treatment with a regimen of these products improved the appearance of facial wrinkles after eight weeks. Changes in treated subjects' stratum corneum protein biomarker levels were consistent with the mechanistic pathways identified in the genomic work. Thus, leveraging a genomic understanding of skin aging led to the development of a clinically efficacious, aesthetically pleasing cosmetic regimen that improved the appearance of aged skin.
authors.affiliation: The Procter & Gamble Company, Cincinnati, OH 45241, USA. kaczvinsky.jr@pg.com
authors.forename: Joseph R
authors.initials: JR
authors.lastname: Kaczvinsky
authors.forename: Pearl E
authors.initials: PE
authors.lastname: Grimes
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D015415:Biomarkers / Q000378:metabolism; D003358:Cosmetics / Q000494:pharmacology; D003879:Dermatologic Agents / Q000494:pharmacology*; D005109:Extracellular Matrix / Q000187:drug effects / Q000378:metabolism; D005145:Face; D005260:Female; D023281:Genomics / Q000379:methods*; D006801:Humans; D008875:Middle Aged; D010539:Permeability / Q000187:drug effects; D011506:Proteins / Q000187:drug effects / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D012867:Skin / Q000187:drug effects* / Q000378:metabolism; D015595:Skin Aging / Q000187:drug effects* / Q000235:genetics; D055815:Young Adult
chemical_list: D015415:Biomarkers; D003358:Cosmetics; D003879:Dermatologic Agents; D011506:Proteins; D017382:Reactive Oxygen Species