title: [Functional 3He-MRI of the lungs].
abstract: Pulmonary diseases have a high health-related and economic significance. (3)He-MRI is an alternative imaging method which can detect ventilatory disturbances with a high sensitivity. The application of different pulse sequences allows static and dynamic assessment of ventilation and bronchial gas flow, non-invasive measurement of intrapulmonary oxygen partial pressure and quantification of pulmonary parenchyma destruction and overinflation. Generally, the method is applicable for obstructive and restrictive ventilatory disturbances but initial approaches also exist for vascular pulmonary diseases. Specific clinical applications remain to be determined but (3)He-MRI is an excellent instrument for the assessment of physiologic and pathophysiologic interrelations in the distribution of ventilation.
authors.affiliation: Klinik und Poliklinik für Diagnostische und Interventionelle Radiologie, Universitätsmedizin der Johannes-Gutenberg-Universität Mainz, Langenbeckstr. 1, 55131 Mainz. kgast@radiologie.klinik.uni-mainz.de
authors.forename: K K
authors.initials: KK
authors.lastname: Gast
authors.forename: U
authors.initials: U
authors.lastname: Wolf
mesh_terms: D003287:Contrast Media; D006371:Helium; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007554:Isotopes; D008168:Lung / Q000473:pathology*; D008171:Lung Diseases / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D012120:Respiration Disorders / Q000175:diagnosis*; D012129:Respiratory Function Tests / Q000379:methods*; D055425:Respiratory-Gated Imaging Techniques / Q000379:methods*
chemical_list: D003287:Contrast Media; D007554:Isotopes; D006371:Helium