title: Backbone resonance assignments for the cytoplasmic regions of G protein-activated inwardly rectifying potassium channel 1 (GIRK1).
abstract: G protein-activated inwardly rectifying potassium channel (GIRK) plays crucial roles in regulating heart rate and neuronal excitability in eukaryotic cells. A variety of ligands, including heterotrimeric G protein betagamma subunits (G betagamma), bind to the cytoplasmic regions of GIRK and modulate its activity. We established the backbone resonance assignments of (2)H/(13)C/(15)N-labeled cytoplasmic regions of mouse GIRK1, which form a tetramer with a molecular weight of 96 K.
authors.affiliation: Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
authors.forename: Mariko
authors.initials: M
authors.lastname: Yokogawa
authors.forename: Takahiro
authors.initials: T
authors.lastname: Muramatsu
authors.forename: Koh
authors.initials: K
authors.lastname: Takeuchi
authors.forename: Masanori
authors.initials: M
authors.lastname: Osawa
authors.forename: Ichio
authors.initials: I
authors.lastname: Shimada
mesh_terms: D000595:Amino Acid Sequence; D002247:Carbon Isotopes / Q000737:chemistry; D003593:Cytoplasm / Q000737:chemistry*; D051676:G Protein-Coupled Inwardly-Rectifying Potassium Channels / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008969:Molecular Sequence Data; D009587:Nitrogen Isotopes / Q000737:chemistry; D017434:Protein Structure, Tertiary; D021122:Protein Subunits; D011522:Protons
chemical_list: D002247:Carbon Isotopes; D051676:G Protein-Coupled Inwardly-Rectifying Potassium Channels; D009587:Nitrogen Isotopes; D021122:Protein Subunits; D011522:Protons