title: [HIV- and HHV-8-negative primary effusion lymphoma-like lymphoma presenting with lymphomatous effusions complicated by cardiac tamponade-a case report].
abstract: We report a rare case of human immunodeficiency virus (HIV)- and human herpes virus-8 (HHV-8)-negative primary effusion lymphoma (PEL)-like lymphoma presenting with lymphomatous effusions complicated by cardiac tamponade. A 68-year-old woman was hospitalized with generalized weakness in June 2006. Echocardiogram revealed the presence of pericardial effusion and she had the signs of cardiac tamponade. Urgent pericardial drainage relieved her symptoms. Chest computed tomography showed bilateral pleural effusions along with pericardial effusion. Cytologic findings of both effusions were suggestive of malignancies, including malignant lymphoma. Immunocytochemical studies with a panel of antibodies, including CD20 and CD79a, could not provide a definite diagnosis. Flow cytometric analysis of pleural effusion revealed that tumor cells were positive for CD10 and CD19, but negative for CD20, CD23, surface immunoglobulin, and T-cell associated antigens. Clonal rearrangement of the immunoglobulin heavy chain gene was detected by Southern blot analysis. Polymerase chain reaction proved to be negative for HHV-8. The serology test for HIV was negative. After a diagnosis of HHV-8-negative PEL-like lymphoma, she was treated with CHOP chemotherapy (cyclophosphamide, doxorubicin, vincristine and prednisolone). However, she died of progressive lymphoma 7 months after the diagnosis. PEL-like lymphomas are of B-cell origin. In some cases of PEL-like lymphoma, tumor cells may be negative for representative markers of B-cell phenotype such as CD20 and CD79a.
authors.affiliation: Dept. of Endocrinology and Metabolism, Internal Medicine, University of The Ryukyus School of Medicine.
authors.forename: Tamiko
authors.initials: T
authors.lastname: Taira
authors.forename: Akitoshi
authors.initials: A
authors.lastname: Nagasaki
authors.forename: Taeko
authors.initials: T
authors.lastname: Okudaira
authors.forename: Takashi
authors.initials: T
authors.lastname: Miyagi
authors.forename: Kayori
authors.initials: K
authors.lastname: Iha
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Takushi
authors.forename: Ichiro
authors.initials: I
authors.lastname: Chinen
authors.forename: Satoshi
authors.initials: S
authors.lastname: Higa
authors.forename: Takashi
authors.initials: T
authors.lastname: Nakayama
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Takasu
mesh_terms: D000368:Aged; D015139:Blotting, Southern; D002305:Cardiac Tamponade / Q000150:complications*; D005260:Female; D006678:HIV / Q000276:immunology; D019288:Herpesvirus 8, Human / Q000276:immunology; D006801:Humans; D054685:Lymphoma, Primary Effusion; D010490:Pericardial Effusion / Q000150:complications*; D016066:Pleural Effusion, Malignant / Q000150:complications; D016133:Polymerase Chain Reaction