Introduction: genes, cognition and neuropsychiatry.
Numerous genes modulate dopamine and consequently prefrontal cortical function. Some of these genes - notably catechol-O-methyltransferase - have been shown to impact a variety of core cognitive processes that are dependent upon the prefrontal cortex. This demonstration that a single functional polymorphism can contribute so dramatically to individual differences heralds a new era for neuropsychiatry. Although enormous detail remains to be discovered about these various genes that regulate neurotransmitters, how they interact and how they affect brain systems, there is much excitement and promise regarding new neuropsychopharmacological possibilities. However, this new research program is magnitudes more complex than any enterprise embarked on hitherto and requires the development, validation and deployment of novel behavioural and neurophysiological phenotypes in order to unravel the pathologies within neural functional systems. This research foundation is essential if these genetic breakthroughs are to be translated to successful clinical agents.
Elvevåg
Brita
B
Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA. elvevaagb@mail.nih.gov
Weinberger
Daniel R
DR
D000818:Animals; D003071:Cognition / Q000502:physiology*; D004298:Dopamine / Q000502:physiology; D006801:Humans; D007206:Individuality; D001523:Mental Disorders / Q000235:genetics* / Q000523:psychology*; D009462:Neurology; D011570:Psychiatry
D004298:Dopamine