title: Internet-based self-management plus education compared with usual care in asthma: a randomized trial.
abstract: BACKGROUND
  The Internet may support patient self-management of chronic conditions, such as asthma.
  
  
  OBJECTIVE
  To evaluate the effectiveness of Internet-based asthma self-management.
  
  
  METHODS
  Randomized, controlled trial.
  
  
  METHODS
  37 general practices and 1 academic outpatient department in the Netherlands.
  
  
  METHODS
  200 adults with asthma who were treated with inhaled corticosteroids for 3 months or more during the previous year and had access to the Internet.
  
  
  METHODS
  Asthma-related quality of life at 12 months (minimal clinically significant difference of 0.5 on the 7-point scale), asthma control, symptom-free days, lung function, and exacerbations.
  
  
  METHODS
  Participants were randomly assigned by using a computer-generated permuted block scheme to Internet-based self-management (n = 101) or usual care (n = 99). The Internet-based self-management program included weekly asthma control monitoring and treatment advice, online and group education, and remote Web communications.
  
  
  RESULTS
  Asthma-related quality of life improved by 0.56 and 0.18 points in the Internet and usual care groups, respectively (adjusted between-group difference, 0.38 [95% CI, 0.20 to 0.56]). An improvement of 0.5 point or more occurred in 54% and 27% of Internet and usual care patients, respectively (adjusted relative risk, 2.00 [CI, 1.38 to 3.04]). Asthma control improved more in the Internet group than in the usual care group (adjusted difference, -0.47 [CI, -0.64 to -0.30]). At 12 months, 63% of Internet patients and 52% of usual care patients reported symptom-free days in the previous 2 weeks (adjusted absolute difference, 10.9% [CI, 0.05% to 21.3%]). Prebronchodilator FEV1 changed with 0.24 L and -0.01 L for Internet and usual care patients, respectively (adjusted difference, 0.25 L [CI, 0.03 to 0.46 L]). Exacerbations did not differ between groups.
  
  
  CONCLUSIONS
  The study was unblinded and lasted only 12 months.
  
  
  CONCLUSIONS
  Internet-based self-management resulted in improvements in asthma control and lung function but did not reduce exacerbations, and improvement in asthma-related quality of life was slightly less than clinically significant.
  
  
  BACKGROUND
  Netherlands Organization for Health Research and Development, ZonMw, and Netherlands Asthma Foundation.
authors.affiliation: Leiden University Medical Center, Leiden, The Netherlands. v.van_der_meer@lumc.nl
authors.forename: Victor
authors.initials: V
authors.lastname: van der Meer
authors.forename: Moira J
authors.initials: MJ
authors.lastname: Bakker
authors.forename: Wilbert B
authors.initials: WB
authors.lastname: van den Hout
authors.forename: Klaus F
authors.initials: KF
authors.lastname: Rabe
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Sterk
authors.forename: Job
authors.initials: J
authors.lastname: Kievit
authors.forename: Willem J J
authors.initials: WJ
authors.lastname: Assendelft
authors.forename: Jacob K
authors.initials: JK
authors.lastname: Sont
mesh_terms: D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000328:Adult; D000465:Algorithms; D018927:Anti-Asthmatic Agents / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D006801:Humans; D020407:Internet; D008168:Lung / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010043:Outcome and Process Assessment, Health Care; D010353:Patient Education as Topic / Q000379:methods*; D011788:Quality of Life; D012648:Self Care / Q000379:methods*; D011795:Surveys and Questionnaires; D055815:Young Adult
chemical_list: D000305:Adrenal Cortex Hormones; D018927:Anti-Asthmatic Agents