title: A neurocomputational model for cocaine addiction.
abstract: Based on the dopamine hypotheses of cocaine addiction and the assumption of decrement of brain reward system sensitivity after long-term drug exposure, we propose a computational model for cocaine addiction. Utilizing average reward temporal difference reinforcement learning, we incorporate the elevation of basal reward threshold after long-term drug exposure into the model of drug addiction proposed by Redish. Our model is consistent with the animal models of drug seeking under punishment. In the case of nondrug reward, the model explains increased impulsivity after long-term drug exposure. Furthermore, the existence of a blocking effect for cocaine is predicted by our model.
authors.affiliation: Control and Intelligent Processing Center of Excellence, School of Electrical and Computer Engineering, University of Tehran, Tehran, Iran. a.dezfouli@ut.ac.ir
authors.forename: Amir
authors.initials: A
authors.lastname: Dezfouli
authors.forename: Payam
authors.initials: P
authors.lastname: Piray
authors.forename: Mohammad Mahdi
authors.initials: MM
authors.lastname: Keramati
authors.forename: Hamed
authors.initials: H
authors.lastname: Ekhtiari
authors.forename: Caro
authors.initials: C
authors.lastname: Lucas
authors.forename: Azarakhsh
authors.initials: A
authors.lastname: Mokri
mesh_terms: D000465:Algorithms; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000503:physiopathology*; D001923:Brain Chemistry / Q000187:drug effects / Q000502:physiology; D003042:Cocaine / Q000494:pharmacology*; D019970:Cocaine-Related Disorders / Q000503:physiopathology*; D003198:Computer Simulation; D003657:Decision Making / Q000187:drug effects / Q000502:physiology; D004195:Disease Models, Animal; D004298:Dopamine / Q000378:metabolism; D018765:Dopamine Uptake Inhibitors / Q000494:pharmacology; D006801:Humans; D007175:Impulsive Behavior / Q000139:chemically induced / Q000503:physiopathology; D007858:Learning / Q000187:drug effects / Q000502:physiology; D012054:Reinforcement, Psychology; D012201:Reward
chemical_list: D018765:Dopamine Uptake Inhibitors; D003042:Cocaine; D004298:Dopamine