IVF/ICSI with or without preimplantation genetic screening for aneuploidy in couples without genetic disorders: a systematic review and meta-analysis.
OBJECTIVE
To assess the efficacy of preimplantation genetic screening to increase ongoing pregnancy rates in couples without known genetic disorders.


METHODS
Systematic review and meta-analysis of randomized controlled trials. Two reviewers independently determined study eligibility and extracted data.


RESULTS
Ten randomized trials (1,512 women) were included. The quality of evidence was moderate. Meta-analyses using a random-effects model suggest that PGS has a lower rate of ongoing pregnancies (risk ratio=0.73, 95% confidence interval 0.62-0.87) and a lower rate of live births (risk ratio=0.76, 95% confidence interval 0.64-0.91) than standard in vitro fertilization/intracytoplasmic sperm injection.


CONCLUSIONS
In women with poor prognosis or in general in vitro fertilization program, in vitro fertilization/intracytoplasmic sperm injection with preimplantation genetic screening for aneuploidy does not increase but instead was associated with lower rates of ongoing pregnancies and live births. The use of preimplantation genetic screening in daily practice does not appear to be justified.
Checa
Miguel A
MA
Department of Obstetrics and Gynecology, Hospital Universitari del Mar, Autonomous University of Barcelona, Passeig Marítim 25-29, Barcelona 08003, Spain. macheca@imas.imim.es
Alonso-Coello
Pablo
P
Solà
Ivan
I
Robles
Ana
A
Carreras
Ramón
R
Balasch
Juan
J
D000022:Abortion, Spontaneous; D000328:Adult; D000782:Aneuploidy; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D030342:Genetic Diseases, Inborn / Q000175:diagnosis* / Q000235:genetics*; D006801:Humans; D008297:Male; D008423:Maternal Age; D011247:Pregnancy; D019836:Preimplantation Diagnosis / Q000379:methods*; D011379:Prognosis; D016032:Randomized Controlled Trials as Topic; D020554:Sperm Injections, Intracytoplasmic / Q000379:methods*; D016896:Treatment Outcome