title: Association of lipid levels during gestation with preeclampsia and gestational diabetes mellitus: a population-based study.
abstract: OBJECTIVE
  The study evaluates lipids profile changes during gestation in pregnancies with and without preeclampsia and/or gestational diabetes.
  
  
  METHODS
  Lipid profiles were assessed between year prior and after pregnancy in 9911 women without cardiovascular comorbidities.
  
  
  RESULTS
  Lipid levels during gestation varied substantially with a nadir following conception and a peak at delivery. Compared to preconception levels total cholesterol levels increased from 164.4 mg/dL to 238.6 mg/dL and triglycerides (TGs) from 92.6 mg/dL to 238.4 mg/dL. The composite endpoint (gestational diabetes mellitus or preeclampsia) occurred in 1209 women (12.2%). Its prevalence increased with levels of TG-from 7.2% in the group with low TGs (<25th percentile adjusted for the gestational month) to 19.8% in the group with high TGs (>75th percentile), but was not associated with high-density lipoprotein levels. In multivariate analysis higher TGs levels, but not low high-density lipoprotein, were associated with the primary endpoint.
  
  
  CONCLUSIONS
  Lipid levels change substantially during gestation. Abnormal levels of TGs are associated with pregnancy complications.
authors.affiliation: Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Be'er-Sheva, Israel.
authors.forename: Arnon
authors.initials: A
authors.lastname: Wiznitzer
authors.forename: Amit
authors.initials: A
authors.lastname: Mayer
authors.forename: Victor
authors.initials: V
authors.lastname: Novack
authors.forename: Eyal
authors.initials: E
authors.lastname: Sheiner
authors.forename: Harel
authors.initials: H
authors.lastname: Gilutz
authors.forename: Atul
authors.initials: A
authors.lastname: Malhotra
authors.forename: Lena
authors.initials: L
authors.lastname: Novack
mesh_terms: D000328:Adult; D002784:Cholesterol / Q000097:blood*; D003430:Cross-Sectional Studies; D016640:Diabetes, Gestational / Q000097:blood* / Q000453:epidemiology*; D005260:Female; D006801:Humans; D011225:Pre-Eclampsia / Q000097:blood* / Q000453:epidemiology*; D011247:Pregnancy; D014280:Triglycerides / Q000097:blood*
chemical_list: D014280:Triglycerides; D002784:Cholesterol