title: Hepatitis C virus kinetics during the first phase of pegylated interferon-alpha-2b with ribavirin therapy in patients with living donor liver transplantation.
abstract: OBJECTIVE
  To identify the problems of pegylated interferon (PEG IFN) with ribavirin therapy against hepatitis C virus (HCV) reinfection in living donor liver transplantation (LDLT) patients. HCV kinetics during the PEG IFN with ribavirin therapy were analyzed in LDLT patients, as well as in chronic hepatitis C (CHC) patients.
  
  
  METHODS
  The study included 80 consecutive HCV infected patients undergoing PEG IFN with ribavirin therapy (64 CHC and 16 LDLT patients) who attended the Nagasaki University Hospital for an initial visit between January 2005 and December 2007.
  
  
  RESULTS
  The sustained viral response (VR) rate of the CHC group (80%) was superior to the LDLT group (22%). The viral disappearance rate of the CHC group was also superior to the LDLT group, regardless of the HCV serotype. The HCV core antigen (cAg) titer under treatment in the LDLT group was more than that of the CHC group from day 0 to week 12. The HCV cAg decrease rate of the LDLT group on the first day of treatment was less than that of the CHC group.
  
  
  CONCLUSIONS
  The HCV infection of a transplanted liver is more refractory to treatment than a non-transplanted liver. The low reduction HCV cAg rate on day 1 is one of the problems of the combination therapy.
authors.affiliation: The First Department of Internal Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
authors.forename: Tatsuki
authors.initials: T
authors.lastname: Ichikawa
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Nakao
authors.forename: Hisamitsu
authors.initials: H
authors.lastname: Miyaaki
authors.forename: Susumu
authors.initials: S
authors.lastname: Eguchi
authors.forename: Mitsuhisa
authors.initials: M
authors.lastname: Takatsuki
authors.forename: Masumi
authors.initials: M
authors.lastname: Fujimito
authors.forename: Motohisa
authors.initials: M
authors.lastname: Akiyama
authors.forename: Satoshi
authors.initials: S
authors.lastname: Miuma
authors.forename: Eisuke
authors.initials: E
authors.lastname: Ozawa
authors.forename: Hidetaka
authors.initials: H
authors.lastname: Shibata
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Takeshita
authors.forename: Takashi
authors.initials: T
authors.lastname: Kanematsu
authors.forename: Katsumi
authors.initials: K
authors.lastname: Eguchi