title: Epinastine: topical ophthalmic second generation antihistamine without significant systemic side effects.
abstract: BACKGROUND
  Epinastine is a topical ophthalmic antihistamine and a mast cell stabilizer indicated for treatment of symptoms associated with allergic conjunctivitis.
  
  
  OBJECTIVE
  The objective of this review is to provide a comprehensive overview of the pharmacology, clinical efficacy, tolerability and safety of epinastine 0.05% ophthalmic solution.
  
  
  METHODS
  Medline literature review from 1950 to 2008.
  
  
  CONCLUSIONS
  Epinastine 0.05% ophthalmic solution was found to be a safe and effective medication for the relief of symptoms of allergic conjunctivitis. Epinastine demonstrates very low CNS and cardiac toxicity.
authors.affiliation: University of Pittsburgh Medical Center, Eye and Ear Institute, PA 15213, USA.
authors.forename: Shilpi
authors.initials: S
authors.lastname: Pradhan
authors.forename: Kumar
authors.initials: K
authors.lastname: Abhishek
authors.forename: Francis
authors.initials: F
authors.lastname: Mah
mesh_terms: D002986:Clinical Trials as Topic; D003233:Conjunctivitis, Allergic / Q000188:drug therapy*; D003984:Dibenzazepines / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use*; D006633:Histamine Antagonists / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use*
chemical_list: D003984:Dibenzazepines; D006633:Histamine Antagonists; D007093:Imidazoles; C053090:epinastine