Fragmented coronoid process in the dog: a heritable disease.
Fragmented coronoid process (FCP) is one of the main diseases associated with elbow dysplasia. FCP is often diagnosed in medium-to-large breed dogs with front leg lameness, for instance in Rottweilers, Labrador Retrievers and Bernese Mountain dogs. Dogs with FCP develop osteoarthrosis of the elbow joint despite conservative or surgical treatment. Although FCP is considered a hereditary condition, the gene or genes causing FCP have yet to be identified. This article provides an overview of different aspects of FCP, including elbow joint development, hypotheses about disease pathogenesis, the genetic background of FCP, and genetic methodology to identify gene or genes responsible for FCP.
Temwichitr
Jedee
J
Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 108, P.O. Box 80154, 3508 TD Utrecht, The Netherlands.
Leegwater
Peter A J
PA
Hazewinkel
Herman A W
HA
D000818:Animals; D004283:Dog Diseases / Q000235:genetics*; D004285:Dogs; D005260:Female; D005552:Forelimb; D008040:Genetic Linkage; D007592:Joint Diseases / Q000235:genetics / Q000662:veterinary*; D007596:Joints / Q000503:physiopathology; D007794:Lameness, Animal / Q000235:genetics; D008297:Male; D010003:Osteoarthritis / Q000235:genetics / Q000662:veterinary*; D010375:Pedigree