Stable encoding of task structure coexists with flexible coding of task events in sensorimotor striatum.
The sensorimotor striatum, as part of the brain's habit circuitry, has been suggested to store fixed action values as a result of stimulus-response learning and has been contrasted with a more flexible system that conditionally assigns values to behaviors. The stability of neural activity in the sensorimotor striatum is thought to underlie not only normal habits but also addiction and clinical syndromes characterized by behavioral fixity. By recording in the sensorimotor striatum of mice, we asked whether neuronal activity acquired during procedural learning would be stable even if the sensory stimuli triggering the habitual behavior were altered. Contrary to expectation, both fixed and flexible activity patterns appeared. One, representing the global structure of the acquired behavior, was stable across changes in task cuing. The second, a fine-grain representation of task events, adjusted rapidly. Such dual forms of representation may be critical to allow motor and cognitive flexibility despite habitual performance.
Kubota
Yasuo
Y
Department of Brain and Cognitive Sciences and McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Liu
Jun
J
Hu
Dan
D
DeCoteau
William E
WE
Eden
Uri T
UT
Smith
Anne C
AC
Graybiel
Ann M
AM
D000161:Acoustic Stimulation; D000818:Animals; D001307:Auditory Perception / Q000502:physiology*; D003342:Corpus Striatum / Q000502:physiology*; D003463:Cues; D007858:Learning / Q000502:physiology*; D008297:Male; D018782:Maze Learning; D051379:Mice; D008810:Mice, Inbred C57BL; D008839:Microelectrodes; D009473:Neuronal Plasticity; D009474:Neurons / Q000502:physiology*; D009483:Neuropsychological Tests; D010812:Physical Stimulation; D011597:Psychomotor Performance / Q000502:physiology; D055698:Touch Perception / Q000502:physiology*