title: A novel injectable hydrogel in combination with a surgical sealant in a rat knee osteochondral defect model.
abstract: Osteochondral defects are frequent, painful, debilitating and expensive to treat, often resulting in poor results. The goal of the present study was to synthesize and characterize a novel biocompatible and biodegradable hydrogel comprised of poly(ethylene glycol), gelatin, and genipin, and examine the hydrogel as an injectable biomaterial in combination with a cyanoacrylate-based surgical sealant for cartilage repair. An osteochondral knee defect was generated in 24 rats, then the hydrogel, with or without a surgical sealant, was injected into the defect and followed for 14 days. The results demonstrated that the hydrogel is biocompatible and biodegradable, and that the cyanoacrylate-based surgical sealant is a relatively safe option for maintaining the hydrogel in the defect. This is the first study describing a cyanoacrylate-based surgical sealant in combination with a polymer hydrogel for cartilage repair.
authors.affiliation: Division of Plastic Surgery, Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
authors.forename: Natasa D
authors.initials: ND
authors.lastname: Miljkovic
authors.forename: Yen-Chih
authors.initials: YC
authors.lastname: Lin
authors.forename: Mario
authors.initials: M
authors.lastname: Cherubino
authors.forename: Danielle
authors.initials: D
authors.lastname: Minteer
authors.forename: Kacey G
authors.initials: KG
authors.lastname: Marra
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000008:administration & dosage*; D002357:Cartilage Diseases / Q000628:therapy*; D002358:Cartilage, Articular / Q000293:injuries; D004195:Disease Models, Animal; D005260:Female; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000008:administration & dosage*; D007270:Injections, Intra-Articular; D007718:Knee Injuries / Q000628:therapy*; D007719:Knee Joint; D051381:Rats; D014014:Tissue Adhesives / Q000008:administration & dosage*
chemical_list: D001672:Biocompatible Materials; D014014:Tissue Adhesives; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate