The functional promoter polymorphism of the coagulation factor XII gene is not associated with peripheral arterial disease.
Coagulation factor XII (FXII) plays a key role in both coagulation and fibrinolysis and has been associated with cardiovascular disease in some studies. Plasma FXIIa levels are strongly determined by a common functional polymorphism in the promoter of the FXII gene (F12-4C>T). To investigate the potential association of this polymorphism with peripheral arterial disease (PAD), we performed a case-control study including 668 patients with PAD and 762 controls participants without cardiovascular disease. F12 genotype frequencies were not significantly different between patients with PAD and control participants. After adjustment for classical risk factors, the odds ratio of carriers of a F12 -4T allele for PAD was 1.06 (95% confidence interval 0.86-1.32). F12 genotypes were associated with a modest increase of the mean-activated partial thromboplastin time but not with PAD stage or severity. We conclude that the functional F124C>T polymorphism is not associated with PAD.
Yazdani-Biuki
Babak
B
Division of Rheumatology, Medical University Graz, Austria.
Krippl
Peter
P
Brickmann
Kerstin
K
Fuerst
Florentine
F
Langsenlehner
Uwe
U
Paulweber
Bernhard
B
Pilger
Ernst
E
Wascher
Thomas C
TC
Brezinschek
Hans-Peter
HP
Renner
Wilfried
W
D000368:Aged; D016022:Case-Control Studies; D005174:Factor XII / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010314:Partial Thromboplastin Time; D016491:Peripheral Vascular Diseases / Q000235:genetics*; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic / Q000235:genetics*; D012307:Risk Factors; D012907:Smoking / Q000453:epidemiology
D005174:Factor XII