Chromium III exposure inhibits brain Na+K+ATPase activity of Clarias batrachus L. involving lipid peroxidation and deficient mitochondrial electron transport chain activity.
The present study elucidated the role of lipid peroxidation and diminished mitochondrial electron transport chain activity in partial dysfunction of brain Na+K+ATPase of Clarias batrachus exposed to chromium III ions. The fish were exposed to 10% and 20% of the derived 96 h LC50 value, 5.69 mg/L and 11.38 mg/L, respectively, and sampled on 20, 40 and 60 days. Exposure to chromium III on fish brain demonstrated an increased lipid peroxidation, production of protein carbonyl and reactive oxygen species and loss of protein thiol groups in synaptosomal fraction with decreased activity of Na+K+ATPase, partial inactivation of mitochondrial electron transport chain activity and energy depletion.
Maiti
A K
AK
Environmental Physiology Laboratory, Department of Physiology, University of Kalyani, Nadia, West Bengal 741235, India.
Paul
G
G
Maity
B
B
Mazumdar
D
D
Saha
N C
NC
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D002397:Catfishes; D002857:Chromium / Q000633:toxicity*; D004579:Electron Transport / Q000187:drug effects; D015227:Lipid Peroxidation; D017382:Reactive Oxygen Species; D000254:Sodium-Potassium-Exchanging ATPase / Q000187:drug effects / Q000378:metabolism; D014873:Water Pollutants / Q000633:toxicity*
D017382:Reactive Oxygen Species; D014873:Water Pollutants; D002857:Chromium; D000254:Sodium-Potassium-Exchanging ATPase