[Effect of Panax notoginseng saponins on vascular intima hyperplasia and PCNA expression in rat aorta after balloon angioplasty].
OBJECTIVE
To explore the effect and the mechanism of panax notoginseng saponins (PNS) on the vascular intima hyperplasia and expression of proliferating cell nuclear antigen (PCNA) after aortic intima injury induced ballcon in rats.


METHODS
Model of aortic intima denudation in rats was established by 2.0 forgarty. The rats were randomly divided into sham group, model group, PNS group and atorvastatin group. Drugs were administered at the second day after the aortic intima injury for 14 days. The injured thoracic aorta segment were taken to detected the vascular morphological changes and expression of PCNA by histomorphology and immunohistochemic methods.


RESULTS
The intimal area (IA), intimal thickness (IT), hyperplasia ratio of intimal area (HRIA), the ratio of intimal/mesolamella area and thickness in the model group were significantly higher than those of the sham operation (P<0.01). The above indexes in PNS and atorvastatin group were markedly lower than those in the model group (P<0.05). Compared with the sham group, the expression of PCNA in the model was enhanced remarkably (P<0.01). Compared with the model group, the expression of PCNA in PNS and atorvastatin group was significantly lowered (P<0.01).


CONCLUSIONS
PNS could inhibit intima hyperplasia by inhibiting proliferation of the vascular smooth muscle cell after vascular intima injury.
Wang
Jianling
J
School of Integrated Traditional Chinese and Western Medicine, Hunan University of Traditional Chinese Medicine, Changsha 410208, China. 825wjl@sina.com
Wu
Lu
L
Zhang
Wei
W
Deng
Changqing
C
D015906:Angioplasty, Balloon, Coronary; D000818:Animals; D001011:Aorta / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D049109:Cell Proliferation / Q000187:drug effects; D005786:Gene Expression Regulation / Q000187:drug effects*; D006965:Hyperplasia / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D008297:Male; D053723:Panax notoginseng / Q000737:chemistry*; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism*; D051381:Rats; D012503:Saponins / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D017539:Tunica Intima / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology
D018809:Proliferating Cell Nuclear Antigen; D012503:Saponins