title: Catalyst-Dependent Syntheses of Phosphatidylinositol-5 Phosphate-DiC8 and its Enantiomer.
abstract: Peptide-based catalysts have been applied to the enantioselective syntheses of the title compounds, with this being the first report of the synthesis of an ent-PI5P analogue. The key steps in the synthesis involve asymmetric phosphorylation catalysis. Additional maneuvers were developed with a protecting groups scheme that enabled efficient, streamlined syntheses of these important mediators of biochemical events.
authors.affiliation: Department of Chemistry, Yale University, P. O. Box 208107, New Haven, CT 06520.
authors.forename: Katherine J
authors.initials: KJ
authors.lastname: Kayser-Bricker
authors.forename: Peter A
authors.initials: PA
authors.lastname: Jordan
authors.forename: Scott J
authors.initials: SJ
authors.lastname: Miller