title: Localized malignant pleural mesothelioma: report of two cases.
abstract: Localized malignant pleural mesothelioma is very rare tumor disease. There are sporadic reports in the literature showing that this entity has a different biologic behavior compared with diffuse pleural mesothelioma. We report two cases of radically resected localized pleural malignant mesothelioma, with a previous history of asbestos exposure. Both cases showed a microscopic and immunohistochemical findings of malignant mesothelioma, biphasic and sarcomatoid lympho-histiocitoid variant type, respectively, without evidence of diffuse pleural spread. The first is very peculiar case of bilateral localized malignant pleural mesothelioma with complete response to chemotherapy and localized late recurrence, radically resected and treated with adjuvant radiotherapy. The second case revealed as a solitary localized mass, underwent a complete en bloc resection and adjuvant radiotherapy. Both cases demonstrate that the localized malignant mesothelioma should be distinguished from diffuse form and that complete resection is associated with good prognosis.
authors.affiliation: Oncologia Medica, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Tanzi
authors.forename: Marcello
authors.initials: M
authors.lastname: Tiseo
authors.forename: Eveline
authors.initials: E
authors.lastname: Internullo
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Cacciani
authors.forename: Roberto
authors.initials: R
authors.lastname: Capra
authors.forename: Paolo
authors.initials: P
authors.lastname: Carbognani
authors.forename: Michele
authors.initials: M
authors.lastname: Rusca
authors.forename: Guido
authors.initials: G
authors.lastname: Rindi
authors.forename: Andrea
authors.initials: A
authors.lastname: Ardizzoni
mesh_terms: D000368:Aged; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D010997:Pleural Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D054363:Solitary Fibrous Tumor, Pleural / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery