An evaluation of perioperative pregabalin for prevention and attenuation of postoperative shoulder pain after laparoscopic cholecystectomy.
Postlaparoscopic shoulder pain (PLSP) frequently follows laparoscopic surgery. In this placebo-controlled study, we evaluated the efficacy of two perioperative doses of pregabalin 300 mg 12 h apart for preventing and attenuating PLSP after laparoscopic cholecystectomy. The frequency and severity of PLSP, need for postoperative rescue analgesia, and side effect profiles were assessed for 48 h postoperatively. In both groups, the overall incidence of PLSP did not differ significantly, and the pain score for PLSP, time to first rescue analgesia, and cumulative ketorolac consumption were similar at each timepoint. However, the 2-h postoperative incidence of oversedation was higher with pregabalin.
Chang
Seong-Hwan
SH
Department of Surgery, Konkuk University School of Medicine, 1 Hwayang-Dong, Gwanggin-Gu, Seoul 143-701, South Korea.
Lee
Hae-Won
HW
Kim
Hae-Kyoung
HK
Kim
Seong-Hyop
SH
Kim
Duk-Kyung
DK
D000328:Adult; D000700:Analgesics / Q000008:administration & dosage* / Q000009:adverse effects; D017081:Cholecystectomy, Laparoscopic; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D006801:Humans; D020910:Ketorolac / Q000008:administration & dosage; D010147:Pain Measurement; D010149:Postoperative Pain / Q000517:prevention & control*; D000069583:Pregabalin; D011446:Prospective Studies; D012720:Severity of Illness Index; D020069:Shoulder Pain / Q000517:prevention & control*; D012890:Sleep / Q000187:drug effects; D013997:Time Factors; D005680:gamma-Aminobutyric Acid / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*
D000700:Analgesics; D000069583:Pregabalin; D005680:gamma-Aminobutyric Acid; D020910:Ketorolac