[The diagnostic value of 24-hour bile reflux monitoring in patients with functional dyspepsia].
The pathogenesis of functional dyspepsia is still not clear. One of the supposed mechanisms are disturbences of motility of upper part of gastrointestinal tract. There only the few informations, concerning the role of retrograde refluxes.


OBJECTIVE
Comparative analysis of grade of duodenogastric reflux intensity in healthy subjects and in patients with functional dyspepsia.


METHODS
The study included 40 subjects with functional dyspepsia (the mean age 33.4 +/- 11.8) and 20 clinically healthy subjects (the mean age 36.9 +/- 10.5). Functional dyspepsia was diagnosed according to the Rome III Criteria. In study group other diseases and H. pylori infection were excluded. 24-hour bilirubin concentration monitoring in gastric juice was performed using spectrophotometer (Bilitec 2000, Medtronic). Seven days before the investigation. the patients were told to obtain from drugs intake. On the day of investigation an equal diet was applied.


RESULTS
In the group of healthy subjects the following results were obtained: the total percentage of absorbance time > 0.14 - 12.4 +/- 7.3%, the reflux index--2.6 +/- 1.6 (R/h). In group of subjects with functional dyspepsia the results were higher, respectively: 59.9 +/- 19.6% (p < 0.001) and 9.8 +/- 5.1 (p < 0.001). The total number of reflux and the number of reflux episode, lasting over 5 minutes were also higher.


CONCLUSIONS
(1) In patients with functional dyspepsia the significant longer periods of bilirubin presence in stomach are observed (comparably with healthy subjects). (2) The intensive duodenogastric reflux could be be a reason of dyspeptic symptoms.
Szadkowski
Krzysztof
K
Medical University of Lodz, Department of Gastroenterology and Internal Diseases. gastro@achilles.wam.pl
Romanowski
Marek
M
Chojnacki
Cezary
C
D000328:Adult; D001655:Bile Reflux; D001663:Bilirubin / Q000032:analysis; D004415:Dyspepsia / Q000175:diagnosis* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D013270:Stomach / Q000737:chemistry; D055815:Young Adult
D001663:Bilirubin