title: Metabolic syndrome defined by IDF and AHA/NHLBI correlates better to carotid intima-media thickness than that defined by NCEP ATP III and WHO.
abstract: OBJECTIVE
  We conducted this study to compare the relationships between subclinical atherosclerosis and metabolic syndrome (MS) defined by four definitions in Chinese subjects.
  
  
  METHODS
  In 2006-2007, we enrolled 140 Chinese subjects without reported diabetes in this study. Anthropometric, biochemical profile, and carotid intima-media thickness (IMT) were measured. MS was defined by International Diabetes Federation (IDF), American Heart Association and the National Heart, Lung, and Blood Institute (AHA/NHLBI), National Cholesterol Education Program Adult Treatment Panal III (NCEP-ATP III), and World Health Organization (WHO) criteria.
  
  
  RESULTS
  Subjects with MS defined by IDF and AHA/NHLBI criteria had significantly higher carotid IMT, controlling for age, gender, smoking, and serum LDL-C (MS by IDF, partial r=0.225, p=0.008; AHA/NHLBI, partial r=0.176, p=0.04). The association between carotid IMT and MS defined by NCEP-ATP III or WHO criteria was not significant. Subjects with more components of MS defined by IDF, AHA/NHLBI, or NCEP-ATP III criteria correlated to higher carotid IMT in adjusted models (p-values for trend, MS by IDF, 0.011; AHA/NHLBI, 0.011; NCEP-ATPIII, 0.01; WHO, 0.113).
  
  
  CONCLUSIONS
  MS definitions by IDF and AHA/NHLBI criteria are the best among four definitions in detecting subclinical atherosclerosis in non-diabetic Chinese subjects; whereas MS defined by WHO criteria is the worst.
authors.affiliation: Division of Endocrinology, Department of Internal Medicine, Cardinal Tien Hospital, Xindian 231, Taiwan.
authors.forename: Wen-Ya
authors.initials: WY
authors.lastname: Ma
authors.forename: Hung-Yuan
authors.initials: HY
authors.lastname: Li
authors.forename: Chi Sheng
authors.initials: CS
authors.lastname: Hung
authors.forename: Mao-Shin
authors.initials: MS
authors.lastname: Lin
authors.forename: Fu-Chun
authors.initials: FC
authors.lastname: Chiu
authors.forename: Cheng-Hsin
authors.initials: CH
authors.lastname: Lin
authors.forename: Shyang-Rong
authors.initials: SR
authors.lastname: Shih
authors.forename: Lee-Ming
authors.initials: LM
authors.lastname: Chuang
authors.forename: Jung-Nan
authors.initials: JN
authors.lastname: Wei
mesh_terms: D000005:Abdomen / Q000033:anatomy & histology; D000328:Adult; D002339:Carotid Arteries / Q000473:pathology; D008076:Cholesterol, HDL / Q000097:blood; D003920:Diabetes Mellitus / Q000175:diagnosis / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D054555:National Heart, Lung, and Blood Institute (U.S.); D009765:Obesity / Q000473:pathology; D012955:Societies, Medical; D014280:Triglycerides / Q000097:blood; D017539:Tunica Intima / Q000473:pathology; D017540:Tunica Media / Q000473:pathology; D014481:United States; D014944:World Health Organization
chemical_list: D008076:Cholesterol, HDL; D014280:Triglycerides