title: [New immunoglobulin for treatment of anthrax].
abstract: OBJECTIVE
  To experimentally assess activity and safety of anti-anthrax intravenous immunoglobulin manufactured on standard technology.
  
  
  METHODS
  Plasma from selected donors vaccinated with combined anthrax vaccine was tested by enzyme immunoassay. Samples of plasma with increased titer of anti-anthrax antibodies were merged in one manufacturing load and fractionated in ethanol at negative temperature according to standard technology. Formulation of intravenous immunoglobulin was manufactured according to standard technology of acid-enzyme hydrolysis.
  
  
  RESULTS
  Proved medical technology of donors immune plasma fractionation provided 4 - 8-fold concentration of anti-anthrax antibodies. The finished product contained 5% of protein and was apyrogenic, non-toxic, thermostable, electrophoretically homogenous, had pH 6.65 and meet the requirements for manufacturing batches of human intravenous immunoglobulin.
  
  
  CONCLUSIONS
  Protective effects of experimental human anti-anthrax immunoglobulin were comparable with control biological--equine anti-anthrax immunoglobulin for intramuscular use.
authors.forename: D V
authors.initials: DV
authors.lastname: Borovskiĭ
authors.forename: A N
authors.initials: AN
authors.lastname: Shevtsov
authors.forename: I V
authors.initials: IV
authors.lastname: Darmov
authors.forename: M Iu
authors.initials: MIu
authors.lastname: Lub
authors.forename: G A
authors.initials: GA
authors.lastname: Zaĭtseva
authors.forename: A V
authors.initials: AV
authors.lastname: Drobkova
authors.forename: V Iu
authors.initials: VIu
authors.lastname: Dolmatov
mesh_terms: D000818:Animals; D000881:Anthrax / Q000628:therapy*; D000907:Antibodies, Bacterial / Q000097:blood / Q000276:immunology; D000918:Antibody Specificity; D001408:Bacillus anthracis / Q000276:immunology; D005591:Chemical Fractionation; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D011817:Rabbits
chemical_list: D000907:Antibodies, Bacterial; D016756:Immunoglobulins, Intravenous