Value of Candida serum markers in patients with invasive candidiasis after myeloablative chemotherapy.
Invasive Candida infections are associated with a significant morbidity and mortality. Detection of circulating biomarkers has been shown to precede conventional diagnostic methods, which is important in improving outcome. We investigated the performance of multiple biomarkers using Candida antigen and anti-Candida antibody detection systems of Platelia and Serion and beta-d-glucan detection in serial serum samples from patients, treated for leukemia, with invasive candidiasis. The performance of single assays and combined detection appeared different for patients with 1 or more episodes of neutropenia and is therefore related to the phase of therapy for the underlying leukemia of the patient. These new insights may help to optimize the diagnostic strategies for the diagnosis of invasive candidiasis.
Lunel
Frans M Verduyn
FM
Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands.
Mennink-Kersten
Monique A S H
MA
Ruegebrink
Dorien
D
van der Lee
Henrich A L
HA
Donnelly
J Peter
JP
Blijlevens
Nicole M A
NM
Verweij
Paul E
PE
D000293:Adolescent; D000328:Adult; D000368:Aged; D000908:Antibodies, Fungal / Q000097:blood; D000946:Antigens, Fungal / Q000097:blood; D015415:Biomarkers; D002175:Candida / Q000302:isolation & purification*; D002177:Candidiasis / Q000175:diagnosis*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D019653:Myeloablative Agonists / Q000009:adverse effects / Q000627:therapeutic use*; D055815:Young Adult; D047071:beta-Glucans / Q000097:blood
D000908:Antibodies, Fungal; D000946:Antigens, Fungal; D015415:Biomarkers; D007166:Immunosuppressive Agents; D019653:Myeloablative Agonists; D047071:beta-Glucans