[Apigenin glycosides from Euphorbia humifusa wild].
The investigation on the herbal of Euphorbia humifusa Wild. was carried out in order to find its anti-HBV constituents. The isolation and purification were performed by chromatography such as Sephadex LH-20, MCI GEL CHP 20P, etc. Based on the spectral analysis, five apigenin glycosides were identified as apigenin-7-O-(6"-O-galloyl)-beta-D-glucopyranoside (1), apigenin-7-O-beta-D-apiofuranosyl (1-->2)-beta-D-glucopyranoside (2), apigenin-7-O-beta-D-lutinoside (3), apigenin-7-O-beta-D-glucopyranside (4) and apigenin (5). Among them, compound 1 is a new compound, compound 2 and 3 were isolated from this plant for the first time.
Tian
Ying
Y
Department of Pharmaceutical Chemistry, Institute of Radiation Medicine, Academy of Military Medical Science, Beijing 100850, China.
Liu
Xi-qiao
XQ
Dong
Jun-xing
JX
D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D047310:Apigenin / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D028481:Euphorbia / Q000737:chemistry*; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006027:Glycosides; D056945:Hep G2 Cells; D006514:Hepatitis B Surface Antigens / Q000378:metabolism; D006513:Hepatitis B e Antigens / Q000378:metabolism; D006801:Humans; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry
D000998:Antiviral Agents; D005960:Glucosides; D006027:Glycosides; D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens; C548264:apigenin-7-O-(6''-O-galloyl)-beta-D-glucopyranoside; C548265:apigenin-7-O-beta-D-apiofuranosyl (1-2)-beta-D-glucopyranoside; C548266:apigenin-7-O-beta-D-lutinoside; D047310:Apigenin