title: Design, synthesis and antifungal activity of a series of novel analogs based on diphenyl ketones.
abstract: To find potent fungicides, 35 analogs of diphenyl ketones were synthesized and evaluated for their antifungal activity. These compounds possessed a furyl-carbonyl-phenyl skeleton. Bioassay results showed that the synthesized compounds were effective in promoting the antifungal activity of diphenyl ketones. Compound 3 showed the best activity against the four tested fungi (100%, 100%, 100% and 96.4%) and could be used as potent fungicide for further research.
authors.affiliation: Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.forename: Hui-Min
authors.initials: HM
authors.lastname: Shi
authors.forename: Hong
authors.initials: H
authors.lastname: Jin
authors.forename: Hao-Yu
authors.initials: HY
authors.lastname: Zhao
authors.forename: Guo-Ping
authors.initials: GP
authors.lastname: Zhou
authors.forename: Fang
authors.initials: F
authors.lastname: Wen
authors.forename: Zhi-Yi
authors.initials: ZY
authors.lastname: Yu
authors.forename: Tai-Ping
authors.initials: TP
authors.lastname: Hou
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015195:Drug Design; D005658:Fungi / Q000187:drug effects*; D005663:Furans / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D007659:Ketones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests
chemical_list: C544205:1-(2-furyl)-3-(2-furyl)-2-propen-1-one; D000935:Antifungal Agents; D005663:Furans; D007659:Ketones