title: EUS-FNA predicts 5-year survival in pancreatic endocrine tumors.
abstract: BACKGROUND
  Pancreatic endocrine tumors (PETs) differ in clinical behavior and prognosis. Determination of malignant potential through specimens obtained by EUS-FNA can help in the management of these patients.
  
  
  OBJECTIVE
  To determine the value of EUS-FNA for diagnosing PETs and for classifying their underlying malignant potential based on the World Health Organization (WHO) classification.
  
  
  METHODS
  Single-center, retrospective, cohort study.
  
  
  METHODS
  Tertiary referral hospital.
  
  
  METHODS
  This study involved 86 consecutive patients (44 men, mean age 58 +/- 14 years) who had been diagnosed with PETs and submitted to EUS-FNA from January 1999 to August 2008.
  
  
  METHODS
  EUS-FNA of a pancreatic mass and/or a metastasis site. Immunohistochemistry on microbiopsies or on monolayer cytology was routinely used. The lesions were classified as recommended by the WHO.
  
  
  METHODS
  EUS-FNA sensitivity and 5-year survival rate.
  
  
  RESULTS
  Overall, in 90% (77 of 86) of patients in this study, PET was diagnosed with EUS-FNA. The sensitivity did not vary with tumor size, type, location, or the presence of hormonal secretion. Of 86 patients, 30 (35%) were submitted to surgical resection. The kappa correlation index between the WHO classification obtained by EUS-FNA and by surgery was 0.38 (P = .003). Major discrepancies were found in the group of patients diagnosed with endocrine tumor of uncertain behavior by EUS-FNA, because 72% turned out to have well-differentiated endocrine carcinoma. Sixteen patients (27%) died during a mean follow-up period of 34 +/- 27 months. The 5-year survival rates were 100% for endocrine tumors, 68% for well-differentiated endocrine carcinomas, and 30% for poorly differentiated endocrine carcinomas (P = .008, log-rank test).
  
  
  CONCLUSIONS
  Retrospective design, selection bias, and small sample size.
  
  
  CONCLUSIONS
  This largest single-center experience to date demonstrated the accuracy of EUS-FNA in diagnosing and determining the malignant behavior of PETs. EUS-FNA findings predict 5-year survival in patients with PETs.
authors.affiliation: Unité d'Exploration Médico-Chirurgicale Oncologique, Institut Paoli-Calmettes, France. faff@gbl.com.br
authors.forename: Fátima A F
authors.initials: FA
authors.lastname: Figueiredo
authors.forename: Marc
authors.initials: M
authors.lastname: Giovannini
authors.forename: Genevieve
authors.initials: G
authors.lastname: Monges
authors.forename: Erwan
authors.initials: E
authors.lastname: Bories
authors.forename: Christian
authors.initials: C
authors.lastname: Pesenti
authors.forename: Fabrice
authors.initials: F
authors.lastname: Caillol
authors.forename: Jean Robert
authors.initials: JR
authors.lastname: Delpero
mesh_terms: D044963:Biopsy, Fine-Needle / Q000379:methods*; D018273:Carcinoma, Islet Cell / Q000000981:diagnostic imaging* / Q000401:mortality / Q000473:pathology; D003937:Diagnosis, Differential; D019160:Endosonography; D005260:Female; D005500:Follow-Up Studies; D005602:France / Q000453:epidemiology; D006801:Humans; D007515:Islets of Langerhans / Q000000981:diagnostic imaging / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging* / Q000401:mortality / Q000473:pathology; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate / Q000639:trends; D013997:Time Factors