Modulating T-cell homeostasis with IL-7: preclinical and clinical studies.
Interleukin-7 (IL-7) is required for the development and survival of T cells and plays a critical role in modulating T-cell homeostasis. This review will address current understanding of IL-7 biology, review recent clinical experiences and discuss potential future clinical applications of IL-7, or IL-7 blockade, in the setting of disease.
Capitini
C M
CM
Immunology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. capitinic@mail.nih.gov
Chisti
A A
AA
Mackall
C L
CL
D001327:Autoimmune Diseases / Q000276:immunology / Q000628:therapy; D015658:HIV Infections / Q000276:immunology / Q000628:therapy; D006706:Homeostasis / Q000276:immunology; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D015851:Interleukin-7 / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology / Q000628:therapy; D016032:Randomized Controlled Trials as Topic; D013601:T-Lymphocytes / Q000276:immunology*
D015851:Interleukin-7