Drug-to-drug interaction between dapsone and minocycline: an unusual cause of relapse of toxoplasmic encephalitis in an HIV-infected patient.
HIV-infected patients with opportunistic infections receive therapeutic regimens that often contain numerous drugs and are then exposed to potential drug-to-drug interactions. We report here an unusual case of relapse of toxoplasmic encephalitis in an HIV-infected patient, possibly due to a drug-to-drug interaction between dapsone and minocycline.
Gallien
Sébastien
S
Department of Infectious and Tropical Diseases, Paris 7 Diderot University, Paris, France. sebastien_gallien@yahoo.fr
Bigé
Naike
N
Kitzis
Marie-Dominique
MD
Longuet
Pascale
P
Gervais
Anne
A
Leport
Catherine
C
D000328:Adult; D003622:Dapsone / Q000008:administration & dosage* / Q000009:adverse effects; D004347:Drug Interactions; D004660:Encephalitis / Q000188:drug therapy* / Q000469:parasitology / Q000821:virology; D015658:HIV Infections / Q000469:parasitology*; D015497:HIV-1 / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008911:Minocycline / Q000008:administration & dosage* / Q000009:adverse effects; D012008:Recurrence; D014122:Toxoplasma / Q000302:isolation & purification; D016781:Toxoplasmosis, Cerebral / Q000188:drug therapy* / Q000469:parasitology / Q000821:virology
D003622:Dapsone; D008911:Minocycline