title: Nanotechnology controlled drug delivery for treating bone diseases.
abstract: Rapid developments at the intersection of nanotechnology and controlled drug delivery have triggered exceptional growth in treating various bone diseases. As a result, over the past decade, nanotechnology has contributed tremendously to controlling drug delivery for treating various bone diseases, and in many cases, has led to increased bone regeneration. In this review paper, the recent experimental progress towards using nanotechnology to treat bone-specific diseases is reviewed. Novel applications of different types of nanomaterials (from nanoparticles to 3D nanostructured scaffolds) for treating bone diseases are summarized. In addition, fundamental principles for utilizing nanomaterials to create better drug delivery systems, especially for treating bone diseases and regenerating bone, are emphasized.
authors.affiliation: Brown University, Division of Engineering, Providence, RI 02912, USA.
authors.forename: Lei
authors.initials: L
authors.lastname: Yang
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Webster
mesh_terms: D001847:Bone Diseases / Q000188:drug therapy*; D001861:Bone Regeneration; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry; D006801:Humans; D053758:Nanoparticles; D036103:Nanotechnology; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D054457:Tissue Scaffolds
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004364:Pharmaceutical Preparations