The potential protective effect of low potassium dextran against lipid peroxidation in a rat lung transplantation model.
The overproduction of reactive oxygen species plays an important role in the cascade of events during lung ischemia-reperfusion leading to graft failure. An evaluation of the peripheral markers of oxidative stress and antioxidant enzyme activities was carried out after reperfusion in a rat lung transplant model. The decrease in lipid peroxidation immediately after transplantation ( P < 0.05) may suggest an adaptative response and/or a protective effect of low potassium dextran against lipid peroxidation through natural scavenging mechanisms.
Torres
R L
RL
Respirology, Porto Alegre General Hospital, 900035-903 Porto Alegre, Brazil.
Martins
L K
LK
Picoral
M
M
Auzani
J
J
Fernandes
T R G
TR
Torres
I L S
IL
Ferreira
M B C
MB
Andrade
C F
CF
Belló-Klein
A
A
Cardoso
P F G
PF
D000818:Animals; D002374:Catalase / Q000378:metabolism; D003911:Dextrans / Q000494:pharmacology; D004912:Erythrocytes / Q000187:drug effects* / Q000201:enzymology; D016166:Free Radical Scavengers / Q000494:pharmacology*; D005947:Glucose / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects*; D016040:Lung Transplantation; D008297:Male; D023421:Models, Animal; D019188:Organ Preservation Solutions / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000097:blood / Q000517:prevention & control*; D013482:Superoxide Dismutase / Q000378:metabolism; D013997:Time Factors
D003911:Dextrans; D016166:Free Radical Scavengers; D019188:Organ Preservation Solutions; C083290:low potassium dextran glucose solution; D002374:Catalase; D013482:Superoxide Dismutase; D005947:Glucose