title: Letrozole as a booster therapy in growth hormone deficiency.
abstract: A 13 year old boy presented to us with short stature. Evaluation revealed growth hormone (GH) deficiency. He was treated with GH replacement for 10 months and to further boost up the growth potential, an aromatase inhibitor Letrozole was added to GH therapy. After one year of combination therapy, patient had significant improvement in predicted adult height without a negative impact on pubertal progression.
authors.affiliation: Department of Endocrinology, Medwin Hospitals, Nampally, Hyderabad 500 001, AP, India. hariendo@rediffmail.com
authors.forename: K V S Hari
authors.initials: KV
authors.lastname: Kumar
authors.forename: Muthukrishnan
authors.initials: M
authors.lastname: Jayaraman
authors.forename: Abhyuday
authors.initials: A
authors.lastname: Verma
authors.forename: Kirtikumar D
authors.initials: KD
authors.lastname: Modi
mesh_terms: D000293:Adolescent; D047072:Aromatase Inhibitors / Q000627:therapeutic use*; D006130:Growth Disorders / Q000188:drug therapy*; D013006:Growth Hormone / Q000172:deficiency*; D006801:Humans; D000077289:Letrozole; D008297:Male; D009570:Nitriles / Q000627:therapeutic use*; D014230:Triazoles / Q000627:therapeutic use*
chemical_list: D047072:Aromatase Inhibitors; D009570:Nitriles; D014230:Triazoles; D000077289:Letrozole; D013006:Growth Hormone