The fate of monocytes in atherosclerosis.
Monocytes are the primary inflammatory cell type that infiltrates early atherosclerotic plaques. Their recruitment into plaques drives disease progression. Disease interventions that target monocytes could act at several points: alteration in the phenotype of circulating monocyte subpopulations; reduced recruitment of monocytes into plaques; alterations in the survival of monocyte-derived cells in atherosclerosis; and promotion of migratory egress from plaques to bring about resolution of the plaque inflammatory response. All of these points of intervention will be briefly discussed in this article.
Randolph
G J
GJ
Department of Gene and Cell Medicine, and the Immunology Institute, Mount Sinai School of Medicine, New York, NY 10029, USA. gwendalyn.randolph@mssm.edu
D050197:Atherosclerosis / Q000473:pathology*; D002634:Chemotaxis, Leukocyte / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000276:immunology; D009000:Monocytes / Q000276:immunology* / Q000473:pathology