title: Genome dynamics: transposition and the single cell.
abstract: Ciliate development requires assembly of functional genes from segments separated by intervening sequences now shown to have properties of transposons. This may be a relic of a time when transposition drove genome evolution, leading to the differentiation of the germline micronucleus and somatic macronucleus.
authors.affiliation: Institute of Cell Biology, University of Edinburgh, King's Buildings, Edinburgh EH9 3JR, UK. david.finnegan@ed.ac.uk
authors.forename: David J
authors.initials: DJ
authors.lastname: Finnegan
mesh_terms: D000818:Animals; D016798:Ciliophora / Q000235:genetics* / Q000254:growth & development*; D004251:DNA Transposable Elements / Q000235:genetics*; D019143:Evolution, Molecular; D005786:Gene Expression Regulation / Q000502:physiology*; D018503:Genome, Protozoan / Q000235:genetics*; D048648:Macronucleus / Q000502:physiology; D012098:Reproduction / Q000502:physiology
chemical_list: D004251:DNA Transposable Elements