title: [2.2]Paracyclophane-based monophosphine ligand for palladium-catalyzed cross-coupling reactions of aryl chlorides.
abstract: A new [2.2]paracyclophane-based electron-rich and sterically bulky monophosphine ligand has been synthesized by an efficient and straightforward method. When combined with palladium, this ligand shows excellent performance in the Buchwald-Hartwig amination and Suzuki-Miyaura coupling reactions of various aryl chlorides. In both types of reactions, ortho-substituted, deactivated aryl chlorides are shown to be viable substrates. However, the Suzuki-Miyaura coupling appears to be easier, with palladium loading at 0.1 mol% being feasible.
authors.affiliation: Liverpool Centre for Materials and Catalysis, Department of Chemistry, University of Liverpool, Liverpool, L69 7ZD, UK.
authors.forename: Jiwu
authors.initials: J
authors.lastname: Ruan
authors.forename: Lee
authors.initials: L
authors.lastname: Shearer
authors.forename: Jun
authors.initials: J
authors.lastname: Mo
authors.forename: John
authors.initials: J
authors.lastname: Bacsa
authors.forename: Antonio
authors.initials: A
authors.lastname: Zanotti-Gerosa
authors.forename: Fred
authors.initials: F
authors.lastname: Hancock
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Wu
authors.forename: Jianliang
authors.initials: J
authors.lastname: Xiao