title: Preparation and characterization of nanoparticles based on dextran-drug conjugates.
abstract: The presented concept combines the widely-established use of macromolecular prodrugs with nanoparticulate drug delivery devices. For this purpose, the water-soluble biopolymer dextran was functionalized with poorly water-soluble drugs (ibuprofen, naproxen) via in situ activation of the carboxylic groups with N,N(')-carbonyldiimidazole (CDI). The resulting hydrophobic derivatives self-assemble into nanoparticles with high loading efficiency during nanoprecipitation. The degree of substitution (DS) and the preparation technique strongly influence the size and the size distribution of the resulting nanoparticles. The particle suspensions remained stable over months in a pH value range between 4 and 11. Derivatives with high DS values are more stable against hydrolysis and after the addition of electrolytes than lowly substituted ones. Therefore, a defined tuning of the DS value may allow the adjustment of the pH-dependent hydrolysis rate and, hence, the release of the drugs.
authors.affiliation: Center of Excellence for Polysaccharide Research, Friedrich-Schiller-Universität Jena, Humboldtstrasse 10, D-07743 Jena, Germany.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Hornig
authors.forename: Heike
authors.initials: H
authors.lastname: Bunjes
authors.forename: Thomas
authors.initials: T
authors.lastname: Heinze
mesh_terms: D003911:Dextrans / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D004355:Drug Stability; D007052:Ibuprofen / Q000031:analogs & derivatives* / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry*; D009288:Naproxen / Q000031:analogs & derivatives* / Q000737:chemistry*; D010316:Particle Size
chemical_list: D003911:Dextrans; D004337:Drug Carriers; C545664:dextran ibuprofen ester; C545665:naproxen dextran ester; D009288:Naproxen; D007052:Ibuprofen