title: EEG power spectra differentiate positive and negative subgroups in neuroleptic-naive schizophrenia patients.
abstract: Electroencephalogram spectral power was estimated at 30 scalp locations in 28 neuroleptic-naive, recent-onset schizophrenia (NRS) patients and 25 healthy comparison subjects in the resting eyes closed condition. Weighted relative power values in the various bandwidths were initially compared between NRS subjects and comparison subjects and subsequently between the positive symptom subgroup, negative symptom subgroup, and comparison subjects, to look for characteristic spectral power profiles of the homogeneous symptom subgroups. Significant differences were noted especially in alpha2, delta, and theta bands between NRS patients and healthy comparison subjects, while the positive symptom and negative symptom subgroups showed characteristic spectral power profiles in alpha1, alpha2, delta, and theta bands.
authors.affiliation: Department of Psychiatry at NIMH and Neurosciences (NIMHANS), Bangalore, India. jpj@nimhans.kar.nic.in
authors.forename: John P
authors.initials: JP
authors.lastname: John
authors.forename: Madhavi
authors.initials: M
authors.lastname: Rangaswamy
authors.forename: Kandavel
authors.initials: K
authors.lastname: Thennarasu
authors.forename: Sumant
authors.initials: S
authors.lastname: Khanna
authors.forename: Roopesh B
authors.initials: RB
authors.lastname: Nagaraj
authors.forename: Champadi R
authors.initials: CR
authors.lastname: Mukundan
authors.forename: Nithyananda
authors.initials: N
authors.lastname: Pradhan
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use; D004569:Electroencephalography / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D012559:Schizophrenia / Q000188:drug therapy / Q000503:physiopathology*; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents