The effect of platelet-rich plasma gel in the early phase of patellar tendon healing.
BACKGROUND
The aim of this study is to assess if an application of platelet-rich plasma (PRP) gel would improve the mechanical properties of rabbit's patellar tendon after resecting its central portion.


METHODS
Forty skeletally mature New Zealand White rabbits were used. Two groups ten rabbits each (PRP and control group) were used to evaluate mechanical properties and histology after 14 days and two groups ten rabbits each (PRP and control groups) were used to evaluate mechanical properties and histology after 28 days.


RESULTS
At 14 days, PRP group showed a 72.2% increase in force at failure, a 39.1% increase in ultimate stress, and a 53.1% increase in stiffness, as compared with controls. These changes were statistically significant (P < 0.05). At 28 days, there was no longer any significant difference between PRP and control groups (P > 0.05).


CONCLUSIONS
In our study, the mechanical properties of the regenerated tendon in the PRP group were significantly improved in relation to the control group. It appears that PRP has a strong effect in the early phase of tendon healing. This effect is probably due to the growth factors that are released from the platelets during activation.
Lyras
Dimitris N
DN
Democritus University of Thrace, Argyrokastrou 31B, Vrilissia, Athens, Greece. dimitrislyras@yahoo.gr
Kazakos
Konstantinos
K
Verettas
Dionysios
D
Botaitis
Sotirios
S
Agrogiannis
George
G
Kokka
Anna
A
Pitiakoudis
Michail
M
Kotzakaris
Athanasios
A
D000818:Animals; D001696:Biomechanical Phenomena; D004195:Disease Models, Animal; D017847:Patellar Ligament / Q000187:drug effects* / Q000293:injuries / Q000502:physiology; D010976:Platelet Count; D053657:Platelet-Rich Plasma; D011817:Rabbits; D018709:Statistics, Nonparametric; D013708:Tendon Injuries / Q000503:physiopathology*; D016212:Transforming Growth Factor beta / Q000097:blood; D042461:Vascular Endothelial Growth Factor A / Q000097:blood
D016212:Transforming Growth Factor beta; D042461:Vascular Endothelial Growth Factor A