title: Serum or bile affects the in vitro azole susceptibilities of Candida spp.
abstract: Drug susceptibility tests were performed with a series of Candida spp. in media supplemented with serum or bile. The azole susceptibilities of several medically important Candida spp., including C. albicans but not C. parapsilosis, were significantly reduced in supplemented media. These findings have important implications for the mechanisms of acquired azole resistance in pathogenic fungi.
authors.affiliation: Department of Chemotherapy and Mycoses, National Institute of Infectious Diseases, Shinjuku-ku, Tokyo, Japan.
authors.forename: Minoru
authors.initials: M
authors.lastname: Nagi
authors.forename: Koichi
authors.initials: K
authors.lastname: Tanabe
authors.forename: Yukie
authors.initials: Y
authors.lastname: Takano
authors.forename: Ken
authors.initials: K
authors.lastname: Kikuchi
authors.forename: Yoshitsugu
authors.initials: Y
authors.lastname: Miyazaki
authors.forename: Masakazu
authors.initials: M
authors.lastname: Niimi
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D001393:Azoles / Q000494:pharmacology*; D001646:Bile / Q000378:metabolism*; D002176:Candida albicans / Q000187:drug effects*; D004336:Drug Antagonism; D006801:Humans; D008826:Microbial Sensitivity Tests
chemical_list: D000935:Antifungal Agents; D001393:Azoles