A microprocessor-controlled tracheal insufflation-assisted total liquid ventilation system.
A prototype time cycled, constant volume, closed circuit perfluorocarbon (PFC) total liquid ventilator system is described. The system utilizes microcontroller-driven display and master control boards, gear motor pumps, and three-way solenoid valves to direct flow. A constant tidal volume and functional residual capacity (FRC) are maintained with feedback control using end-expiratory and end-inspiratory stop-flow pressures. The system can also provide a unique continuous perfusion (bias flow, tracheal insufflation) through one lumen of a double-lumen endotracheal catheter to increase washout of dead space liquid. FRC and arterial blood gases were maintained during ventilation with Rimar 101 PFC over 2-3 h in normal piglets and piglets with simulated pulmonary edema induced by instillation of albumin solution. Addition of tracheal insufflation flow significantly improved the blood gases and enhanced clearance of instilled albumin solution during simulated edema.
Parker
James Courtney
JC
Department of Physiology, University of South Alabama, MSB 3074, Mobile, AL 36688, USA. jparker@usouthal.edu
Sakla
Adel
A
Donovan
Francis M
FM
Beam
David
D
Chekuri
Annu
A
Al-Khatib
Mohammad
M
Hamm
Charles R
CR
Eyal
Fabien G
FG
D000818:Animals; D002245:Carbon Dioxide / Q000097:blood; D004867:Equipment Design; D007327:Insufflation / Q000295:instrumentation* / Q000379:methods; D021061:Liquid Ventilation / Q000295:instrumentation* / Q000379:methods; D008838:Microcomputers; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D011654:Pulmonary Edema / Q000628:therapy; D034421:Sus scrofa
D002245:Carbon Dioxide; D010100:Oxygen