title: "Speed" warps time: methamphetamine's interactive roles in drug abuse, habit formation, and the biological clocks of circadian and interval timing.
abstract: The indirect dopamine (DA) agonist methamphetamine (MAP) is evaluated in terms of its impact on the speed of temporal processing across multiple time scales involving both interval and circadian timing. Behavioral and neuropharmacological aspects of drug abuse, habit formation, neurotoxicity, and the potential links between interval and circadian timing are reviewed. The view that emerges is one in which the full spectrum of MAP-induced effects on timing and time perception is both complex and dynamic in as much as it involves DA-glutamate interactions and gene expression within cortico-striatal circuitry spanning oscillation periods ranging from milliseconds to multiple hours. The conclusion is that the psychostimulant properties of MAP are very much embedded within the context of temporal prediction and the anticipation of reward.
authors.affiliation: Department of Psychology and Neuroscience, Duke University, Durham, North Carolina 27708, USA.
authors.forename: Lauren L
authors.initials: LL
authors.lastname: Williamson
authors.forename: Ruey-Kuang
authors.initials: RK
authors.lastname: Cheng
authors.forename: Mikel
authors.initials: M
authors.lastname: Etchegaray
authors.forename: Warren H
authors.initials: WH
authors.lastname: Meck
mesh_terms: D019969:Amphetamine-Related Disorders / Q000175:diagnosis / Q000503:physiopathology / Q000523:psychology*; D000818:Animals; D000697:Central Nervous System Stimulants; D002540:Cerebral Cortex / Q000187:drug effects / Q000503:physiopathology; D002940:Circadian Rhythm / Q000187:drug effects*; D003342:Corpus Striatum / Q000187:drug effects / Q000503:physiopathology; D004193:Discrimination Learning / Q000187:drug effects / Q000502:physiology; D004298:Dopamine / Q000502:physiology; D018491:Dopamine Agonists; D004305:Dose-Response Relationship, Drug; D005059:Euphoria / Q000187:drug effects / Q000502:physiology; D018698:Glutamic Acid / Q000502:physiology; D006801:Humans; D008032:Limbic System / Q000187:drug effects / Q000503:physiopathology; D008568:Memory / Q000187:drug effects / Q000502:physiology; D008694:Methamphetamine; D009415:Nerve Net / Q000187:drug effects / Q000503:physiopathology; D009638:Norepinephrine / Q000502:physiology; D051381:Rats; D012701:Serotonin / Q000502:physiology; D013998:Time Perception / Q000187:drug effects*
chemical_list: D000697:Central Nervous System Stimulants; D018491:Dopamine Agonists; D012701:Serotonin; D018698:Glutamic Acid; D008694:Methamphetamine; D004298:Dopamine; D009638:Norepinephrine