LTD induction suppresses LTP-induced hippocampal adult neurogenesis.
Neurogenesis persists in certain adult brain regions including the dentate gyrus. Recent studies have shown that long-term potentiation (LTP) induction in the afferent pathway enhances adult neurogenesis in the dentate gyrus. Here, we investigated whether long-term depression (LTD) induction also affects adult neurogenesis. We induced LTD in the dentate gyrus in one hemisphere and compared the amount of progenitor proliferation with that in the other hemisphere. Unlike LTP induction, LTD induction per se did not affect progenitor cell proliferation in the dentate gyrus. However, when LTD was induced a day before LTP induction, neuronal progenitor cell proliferation facilitated by LTP induction was markedly blunted. These results show that two forms of synaptic plasticity, LTP and LTD, differentially influence hippocampal adult neurogenesis.
Chun
Sung Kun
SK
Neuroscience Laboratory, Institute for Medical Sciences, Ajou University School of Medicine, Suwon 443-721, Korea.
Sun
Woong
W
Jung
Min Whan
MW
D053687:Adult Stem Cells / Q000502:physiology*; D000818:Animals; D001973:Bromodeoxyuridine; D002452:Cell Count; D049109:Cell Proliferation; D018891:Dentate Gyrus / Q000502:physiology*; D019706:Excitatory Postsynaptic Potentials; D017774:Long-Term Potentiation / Q000502:physiology*; D036881:Long-Term Synaptic Depression / Q000502:physiology*; D008297:Male; D055495:Neurogenesis / Q000502:physiology*; D019580:Perforant Pathway / Q000502:physiology; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D055153:Stem Cell Niche / Q000502:physiology; D013997:Time Factors
D018809:Proliferating Cell Nuclear Antigen; D001973:Bromodeoxyuridine