[Coenzyme A biosynthesis as universal mechanism of conjugation of exogenous and multiple pantothenic acid functions].
Development of Academician R. V. Chagovets' ideas of the regulatory role of vitamins and their derivatives in thiol-containing compound metabolism and antioxidant system formation as well as in studying non-coenzymatic functions of B-vitamins and vitamin-binding proteins had a considerable effect on the almost 40-year studies on pantothenic acid metabolism and biochemical functions by scholars at the vitaminologic school in Grodno. The concept concerning the intracellular structure of the pantothenate coenzyme form, CoA, pool (content and ratio of CoA-SH, acetyl-CoA, short-chain and long-chain acyls-CoA, coenzyme disulfide forms and CoA-S-S-proteins) was substantiated as an important metabolic regulatory factor (including glutathione system redox potential), with changes being a principal mechanism of pantothenate derivative vitamin and pharmacotherapeutic activity implementation. The effect of the latter is mediated through the systems of CoA biosynthesis and phosphopantetheine proteins, changed CoA-S-S-protein levels, which in turn maintain the intracellular level of CoA-SH as well as cytosolic and mitochondrial transport of its vitamin-containing precursors. A universal CoA biosynthetic function was revealed in prevention of lipid peroxidation initiation and oxidative stress development.
Moĭseenok
A G
AG
Gurinovich
V A
VA
Omel'ianchik
S N
SN
Slyshenkov
V S
VS
D000818:Animals; D017209:Apoptosis / Q000502:physiology; D003065:Coenzyme A / Q000096:biosynthesis* / Q000502:physiology; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology; D051336:Mitochondrial Membranes / Q000378:metabolism; D010205:Pantothenic Acid / Q000378:metabolism / Q000502:physiology*; D013438:Sulfhydryl Compounds / Q000378:metabolism*; D014803:Vitamin B Complex / Q000378:metabolism / Q000502:physiology*
D013438:Sulfhydryl Compounds; D014803:Vitamin B Complex; D010205:Pantothenic Acid; D003065:Coenzyme A