Plasmid-mediated quinolone resistance in Salmonella isolated from patients with overseas travelers' diarrhea in Japan.
Twenty-eight of the 302 Salmonella strains isolated from patients with overseas travelers' diarrhea who were examined at Kansai Airport Department Station during the 6-year period between 2001 and 2007 showed decreased susceptibility to both nalidixic acid (NA) and ciprofloxacin (CPFX) (MIC of NA, 16-64 microg/mL; MIC of CPFX, 0.064-2.0 microg/mL). These 28 strains revealed no variations in the quinolone resistance-determining region; however, 25 of the strains showed retention of the qnr gene. The qnr-retaining Salmonella belonged to 6 serotypes, and 21 and 4 of the 25 strains showed qnrS1 and qnrS2, respectively. The most common serovar was S. Corvallis (17 strains).
Taguchi
Masumi
M
Osaka Prefectural Institute of Public Health, Higashinari-ku, Osaka, Japan. mstaguch@iph.pref.osaka.jp
Kawahara
Ryuji
R
Seto
Kazuko
K
Inoue
Kiyoshi
K
Hayashi
Akihiro
A
Yamagata
Nobuaki
N
Kamakura
Kazumasa
K
Kashiwagi
Etsurou
E
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000494:pharmacology; D004269:DNA, Bacterial / Q000235:genetics; D003967:Diarrhea / Q000382:microbiology; D024881:Drug Resistance, Bacterial; D005798:Genes, Bacterial; D006801:Humans; D007564:Japan; D008826:Microbial Sensitivity Tests; D009268:Nalidixic Acid / Q000494:pharmacology; D010957:Plasmids; D015363:Quinolones / Q000494:pharmacology*; D012475:Salmonella / Q000187:drug effects* / Q000302:isolation & purification; D012480:Salmonella Infections / Q000382:microbiology*; D014195:Travel
D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D015363:Quinolones; D009268:Nalidixic Acid; D002939:Ciprofloxacin