sTRAIL levels and TRAIL gene polymorphisms in Chinese patients with fatty liver disease.
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily, and has been identified as a novel mediator of fatty liver disease (FLD). The aim of our study was to further investigate the relationship between TRAIL and FLD. We found that soluble TRAIL (sTRAIL) concentrations in non-alcoholic FLD (NAFLD) patients were significantly higher than those of controls, and that sTRAIL levels positively correlated with triglyceride concentrations in NAFLD patients. Our results also indicated that the AA/TT genotypes of TRAIL at 1525/1595 engendered a lower risk of FLD attack and a less severe form of steatosis for NAFLD patients in Chinese population. This study provides a means to test for susceptibility to FLD and may assist in the diagnosis of FLD. In addition, we found that 1525G/A and 1595C/T sites were in complete linkage disequilibrium in Chinese population. This might indicate a haplotype with high genetic frequency of TRAIL.
Yan
Xiaohua
X
Department of Immunology, Shandong University School of Medicine, 44# Wenhua Xi Road, Jinan, 250012, People's Republic of China.
Xu
Liyun
L
Qi
Jianni
J
Liang
Xiaohong
X
Ma
Chunhong
C
Guo
Chun
C
Zhang
Lining
L
Sun
Wensheng
W
Zhang
Jiyun
J
Wei
Xiaoyi
X
Gao
Lifen
L
D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics; D001483:Base Sequence; D016022:Case-Control Studies; D002681:China; D017931:DNA Primers / Q000235:genetics; D005234:Fatty Liver / Q000235:genetics* / Q000276:immunology*; D005235:Fatty Liver, Alcoholic / Q000235:genetics / Q000276:immunology; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D055261:Immunogenetic Phenomena; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012995:Solubility; D053221:TNF-Related Apoptosis-Inducing Ligand / Q000097:blood* / Q000235:genetics*
D017931:DNA Primers; D053221:TNF-Related Apoptosis-Inducing Ligand; C505653:TNFSF10 protein, human