title: [Mechanism of Chinese herbal medicine delaying progression of chronic kidney disease].
abstract: The pathomechanisms of the progression of chronic kidney disease (CKD) include glomerulosclerosis, renal interstitial fibrosis and renal arteriosclerosis. Chinese herbal medicine can delay the progression of CKD by ameliorating the harmful factors of these pathological changes, such as podocyte and slit diaphragm injury, nephrotoxicity of proteinuria, hyperactivity of renin-angiotensin-aldosterone system, cytokines over-expression, tubular epithelial myofibroblast transdifferentiation, hyperlipidemia and hypertension.
authors.affiliation: Nanjing University of Traditional Chinese Medicine, Nanjing 210029, China.
authors.forename: Chenhui
authors.initials: C
authors.lastname: Dou
authors.forename: Yigang
authors.initials: Y
authors.lastname: Wan
authors.forename: Wei
authors.initials: W
authors.lastname: Sun
authors.forename: Huilang
authors.initials: H
authors.lastname: Zhagn
authors.forename: Jing
authors.initials: J
authors.lastname: Chen
authors.forename: Guangxing
authors.initials: G
authors.lastname: Shui
authors.forename: Jian
authors.initials: J
authors.lastname: Yao
mesh_terms: D002908:Chronic Disease; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D007674:Kidney Diseases / Q000188:drug therapy* / Q000378:metabolism; D012084:Renin-Angiotensin System / Q000187:drug effects; D016212:Transforming Growth Factor beta / Q000378:metabolism
chemical_list: D004365:Drugs, Chinese Herbal; D016212:Transforming Growth Factor beta