title: Genetic changes of coxsackievirus A16 and enterovirus 71 isolated from hand, foot, and mouth disease patients in Toyama, Japan between 1981 and 2007.
abstract: We characterized the genetic diversity of the complete VP1 region of coxsackievirus A16 (CA16) and enterovirus 71 (EV71) isolated from patients with hand, foot, and mouth disease in Toyama from 1981 to 2007 to evaluate the relationship between epidemics and genetic changes. The predominant genogroups of CA16 changed from B to C in 1995-1998, and genogroup C further changed from subgenogroup C1 to C2 around 2002, and to C3 in 2005-2007. The subgenogroups of the EV71 isolates were classified into B1, B4, C1, and C3 in 1983-1994, and into C4 in 1997-2006. However, changes of the amino acid sequences of the VP1 regions of CA16 were restored, and those of the EV71 isolates were not observed among the same subgenogroups during this survey period, indicating that the prevalence that occurred at intervals of several years seemed to depend on an accumulating number of immunologically naive children, not viral antigenic changes.
authors.affiliation: Department of Virology, Toyama Institute of Health, Imizu-shi, Toyama, Japan. masae.iwai@pref.toyama.lg.jp
authors.forename: Masae
authors.initials: M
authors.lastname: Iwai
authors.forename: Akio
authors.initials: A
authors.lastname: Masaki
authors.forename: Sumiyo
authors.initials: S
authors.lastname: Hasegawa
authors.forename: Mayumi
authors.initials: M
authors.lastname: Obara
authors.forename: Eiji
authors.initials: E
authors.lastname: Horimoto
authors.forename: Kazuya
authors.initials: K
authors.lastname: Nakamura
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Tanaka
authors.forename: Kyoko
authors.initials: K
authors.lastname: Endo
authors.forename: Keiko
authors.initials: K
authors.lastname: Tanaka
authors.forename: Junko
authors.initials: J
authors.lastname: Ueda
authors.forename: Kimiyasu
authors.initials: K
authors.lastname: Shiraki
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kurata
authors.forename: Takenori
authors.initials: T
authors.lastname: Takizawa
mesh_terms: D016000:Cluster Analysis; D029821:Enterovirus A, Human / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification*; D019143:Evolution, Molecular; D014644:Genetic Variation; D005838:Genotype; D006232:Hand, Foot and Mouth Disease / Q000821:virology*; D006801:Humans; D007564:Japan; D008969:Molecular Sequence Data; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics; D017422:Sequence Analysis, DNA; D015678:Viral Structural Proteins / Q000235:genetics
chemical_list: D012367:RNA, Viral; D015678:Viral Structural Proteins