Synthesis and in-vitro anti-hepatitis-B virus activity of 6H-[1]benzothiopyrano[4,3-b] quinolin-10-ols.
A series of 9-methoxy-6H-[1]benzothiopyrano[4,3-b]quinolin-10-ols with a Mannich side chain were synthesized and evaluated for their anti-Hepatitis B virus (HBV) activity in HepG2.2.15 cells. Some compounds showed significant anti-HBV activity with IC(50) values less than 41 microM. Among them, compound 9b was the most effective anti-HBV agent (IC(50) = 1.7 microM, SI = 60.3).
Jia
Wei
W
School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, China.
Zhao
Yanfang
Y
Li
Rongdong
R
Wu
Yanjiao
Y
Li
Zebiao
Z
Gong
Ping
P
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects*; D004279:DNA, Viral / Q000378:metabolism; D004353:Drug Evaluation, Preclinical; D024882:Drug Resistance, Viral; D006515:Hepatitis B virus / Q000187:drug effects* / Q000378:metabolism; D006912:Hydroxyquinolines / Q000494:pharmacology*; D019259:Lamivudine / Q000494:pharmacology; D015394:Molecular Structure; D013329:Structure-Activity Relationship
D000998:Antiviral Agents; D004279:DNA, Viral; D006912:Hydroxyquinolines; D019259:Lamivudine