title: Aromatic cyclic peroxides and related keto-compounds from the Plakortis sp. component of a sponge consortium.
abstract: Six unreported aromatic compounds, 1-6, were isolated, along with the known compounds dehydrocurcuphenol and manoalide, from a sample of Plakortis sp., which was the main component of a Pacific sponge consortium. The new molecules were chemically characterized by spectroscopic methods. Compounds 1-4 contain a six-membered cyclic peroxide, whereas 5 and 6 display a terminal methyl ketone. The new metabolites were tested for antifungal and antibacterial properties. Compounds 1 and 4 were weakly active against S. aureus.
authors.affiliation: Istituto di Chimica Biomolecolare, CNR, Via Campi Flegrei 34, I 80078-Pozzuoli (Naples), Italy. emanzo@icmib.na.cnr.it
authors.forename: Emiliano
authors.initials: E
authors.lastname: Manzo
authors.forename: M Letizia
authors.initials: ML
authors.lastname: Ciavatta
authors.forename: Dominique
authors.initials: D
authors.lastname: Melck
authors.forename: Peter
authors.initials: P
authors.lastname: Schupp
authors.forename: Nicole
authors.initials: N
authors.lastname: de Voogd
authors.forename: Margherita
authors.initials: M
authors.lastname: Gavagnin
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology; D003500:Cyclization; D004146:Dioxanes / Q000737:chemistry / Q000302:isolation & purification*; D006801:Humans; D007659:Ketones / Q000737:chemistry / Q000302:isolation & purification*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010545:Peroxides / Q000737:chemistry / Q000302:isolation & purification*; D011161:Porifera / Q000737:chemistry*; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification
chemical_list: D000935:Antifungal Agents; D004146:Dioxanes; D007659:Ketones; D010545:Peroxides; D013729:Terpenes; C045673:manoalide