Association of monocyte chemoattractant protein 1 gene polymorphism with susceptibility to nonfamilial idiopathic dilated cardiomyopathy.
BACKGROUND
The cytotoxic action of leukocytes is known to be a probable cause of the cardiac myocyte damage seen in idiopathic dilated cardiomyopathy (IDC). Monocyte chemoattractant protein 1 (MCP-1) contributes to enhanced leukocyte recruitment and activation resulting in chronic damage of cardiomyocytes. MCP-1 has been reported to be dynamically regulated in IDC and may contribute to the deterioration of left ventricular function. In addition, a polymorphism at -2518 (G/A) in the MCP-1 gene affects the level of MCP-1 expression in response to an inflammatory stimulus.


RESULTS
We genotyped the polymorphism at -2518 G/A in the MCP-1 gene in 73 Japanese patients with nonfamilial IDC and 349 healthy controls. The distribution of the MCP-1 genotypes in the IDC patients differed significantly from the controls (p=0.016). In a dominant G allele model, there was a significant difference in the distribution of genotypes between the two groups (p<0.01). The odds ratio for nonfamilial IDC associated with the GG vs. non-GG genotype was 10.4 (95% CI=1.7-64.5) after adjustment for the confounding factors.


CONCLUSIONS
These findings suggest that the G allele at -2518 in the MCP-1 gene may be a novel genetic marker of susceptibility to nonfamilial IDC.
Ogimoto
Akiyoshi
A
Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime 791-0295, Japan. aogimoto@m.ehime-u.ac.jp
Okayama
Hideki
H
Nagai
Takayuki
T
Ohtsuka
Tomoaki
T
Suzuki
Jun
J
Inoue
Katsuji
K
Nishimura
Kazuhisa
K
Shigematsu
Yuji
Y
Tabara
Yasuharu
Y
Kohara
Katsuhiko
K
Miki
Tetsuro
T
Higaki
Jitsuo
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002311:Cardiomyopathy, Dilated / Q000235:genetics*; D018932:Chemokine CCL2 / Q000235:genetics*; D002648:Child; D005260:Female; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D055815:Young Adult
D018932:Chemokine CCL2; D005819:Genetic Markers