title: Synthesis of biotinylated OSW-1.
abstract: OSW-1 is a highly potent anticancer natural saponin with an unknown mode of action. To determine its cellular target(s) biotinylated OSW-1 was successfully synthesized in nine steps.
authors.affiliation: Division of Medicinal and Natural Products Chemistry, College of Pharmacy, The University of Iowa, Iowa City, IA 52242, USA.
authors.forename: Ying
authors.initials: Y
authors.lastname: Kang
authors.forename: Changgang
authors.initials: C
authors.lastname: Lou
authors.forename: Kausar Begam Riaz
authors.initials: KB
authors.lastname: Ahmed
authors.forename: Peng
authors.initials: P
authors.lastname: Huang
authors.forename: Zhendong
authors.initials: Z
authors.lastname: Jin
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*; D001710:Biotin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000633:toxicity; D019921:Biotinylation; D045744:Cell Line, Tumor; D002783:Cholestenones / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D006801:Humans; D012503:Saponins / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D002783:Cholestenones; D012503:Saponins; C106408:OSW 1; D001710:Biotin