title: NMR assignment of the N-terminal region of human La free and in complex with RNA.
abstract: (1)H, (15)N and (13)C chemical shift assignments are presented for the N-terminal region of human La protein, in the apo and 5'-UUUU RNA-bound state. Secondary structure analysis shows conformational changes in the interdomain linker upon complex formation.
authors.affiliation: Randall Division of Cell and Molecular Biophysics, King's College London, New Hunt's House, Guy's Campus, London, SE1 1UL, UK.
authors.forename: Domenico
authors.initials: D
authors.lastname: Sanfelice
authors.forename: Geoff
authors.initials: G
authors.lastname: Kelly
authors.forename: Stephen
authors.initials: S
authors.lastname: Curry
authors.forename: Maria R
authors.initials: MR
authors.lastname: Conte
mesh_terms: D000595:Amino Acid Sequence; D001324:Autoantigens / Q000737:chemistry*; D001665:Binding Sites; D002247:Carbon Isotopes / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008969:Molecular Sequence Data; D008970:Molecular Weight; D009587:Nitrogen Isotopes / Q000737:chemistry; D010446:Peptide Fragments / Q000737:chemistry*; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D011522:Protons; D012313:RNA / Q000737:chemistry*; D016601:RNA-Binding Proteins / Q000737:chemistry*
chemical_list: D001324:Autoantigens; D002247:Carbon Isotopes; C506261:SSB protein, human; D009587:Nitrogen Isotopes; D010446:Peptide Fragments; D011522:Protons; D016601:RNA-Binding Proteins; D012313:RNA