Schisanwilsonins A-G and related anti-HBV lignans from the fruits of Schisandra wilsoniana.
Seven new dibenzocyclooctane lignans, schisanwilsonins A-G (1-7), were isolated from the fruits of Schisandra wilsoniana, together with five known lignans (8-12). The structures of these new compounds were elucidated by spectroscopic methods including 2D-NMR techniques. The 12 lignans were tested for anti-hepatitis B virus (HBV) activity in vitro. Schisanwilsonin D (4), schisantherin C (9), deoxyschizandrin (10) and (+)-gomisin K(3) (11) showed anti-HBV activity. 9 exhibited the most potent anti-HBV activity with potency against HBsAg and HBeAg secretion by 59.7% and 34.7%, respectively, at 50 microg/mL.
Ma
Wen-Hui
WH
Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai, PR China.
Lu
Yan
Y
Huang
Hai
H
Zhou
Pei
P
Chen
Dao-Feng
DF
D000998:Antiviral Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D034242:Cyclooctanes / Q000737:chemistry; D005638:Fruit / Q000737:chemistry; D006514:Hepatitis B Surface Antigens / Q000378:metabolism; D006513:Hepatitis B e Antigens / Q000378:metabolism; D006515:Hepatitis B virus / Q000187:drug effects*; D006801:Humans; D017705:Lignans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D032141:Schisandra / Q000737:chemistry*
D000998:Antiviral Agents; D034242:Cyclooctanes; D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens; D017705:Lignans