title: Severe osteoporosis and high level TSH in a child before the diagnosis of acute lymphoblastic leukemia.
abstract: Osteoporosis in children is rare and mostly secondary to such conditions as prolonged immobilization, malabsorption syndromes, corticosteroid excess, osteogenesis imperfecta, celiac disease, Turner syndrome, and malignancy. Idiopathic juvenile osteoporosis (IJO) is a very rare condition of primary bone demineralization that presents in childhood. IJO, a disease of unknown etiology, manifests typically by pain, bone deformities, and fractures. Diagnosis of IJO was made by excluding other common causes of osteoporosis in this age. Bisphosphonates, calcitriol, fluoride, and calcitonin have been administered therapeutically, but the results were equivocal. Usually the disease remits by itself. Patient that has serious osteoporosis and high thyroid stimulating hormone level was diagnosed as IJO by eliminating secondary reasons. We report this case, whose symptoms were disappeared after parenteral pamidronat treatment, and he was reexamined owing to anemia and trombositopenia, and diagnosed as B-cell acute lymphoblastic leukemia, just to emphasis the importance of close follow-ups of IJO patients.
authors.affiliation: Department of Pediatrics, Medical School of Harran University, Sanliurfa, Turkey. dratasali@gmail.com
authors.forename: Ali
authors.initials: A
authors.lastname: Atas
authors.forename: Alpay
authors.initials: A
authors.lastname: Cakmak
authors.forename: Mustafa
authors.initials: M
authors.lastname: Soran
authors.forename: Murat
authors.initials: M
authors.lastname: Soker
authors.forename: Mustafa
authors.initials: M
authors.lastname: Varma
mesh_terms: D000293:Adolescent; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D050071:Bone Density Conservation Agents / Q000008:administration & dosage; D003937:Diagnosis, Differential; D004164:Diphosphonates / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D010024:Osteoporosis / Q000097:blood* / Q000188:drug therapy; D000077268:Pamidronate; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy; D013972:Thyrotropin / Q000097:blood*
chemical_list: D000970:Antineoplastic Agents; D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D013972:Thyrotropin; D000077268:Pamidronate