[Effect of acellular staphylococcal vaccine "Staphylovac" on several indicators of immune system in mice].
OBJECTIVE
To study molecularand cellular mechanisms of action of "Staphylovac" vaccine on effectors of innate immunity in mice.


METHODS
Dynamics of changes of mice spleen mononuclear leukocytes immunophenotype under the influence of the vaccine at determined time intervals was assessed in the study.


RESULTS
In response to antigenic stimulation mice immune system reacted by increasing number of cells expressing molecules of T-cell subpopulations--CD3, CD4, CD8; B-cell subpopulation--CD19 and natural killers--NK. Activation of immune system of mice was noted which expressed as increased levels of molecules for antigenic presentation (MHCI, MHCII), regulatory molecules (CD4/CD25) as well as enhanced cytotoxicity potential and phagocytic activity.


CONCLUSIONS
Staphylococcal vaccine as well as studied antigens of Staphylococcus aureus promote activation of immune system. Cytotoxic potential obtained by NK cells under their influence as well as enhancement of phagocytic activity of macrophages point to activation of innate immune mechanisms.
Kuz'menko
O M
OM
Akhmatova
N K
NK
Gruber
I M
IM
D000818:Animals; D018941:Antigens, CD19 / Q000378:metabolism; D001402:B-Lymphocytes / Q000276:immunology / Q000378:metabolism; D017252:CD3 Complex / Q000378:metabolism; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism; D003601:Cytotoxicity Tests, Immunologic; D007113:Immunity, Innate / Q000276:immunology; D007694:Killer Cells, Natural / Q000276:immunology; D018655:Lymphocyte Count; D017737:Macrophages, Peritoneal / Q000276:immunology*; D051379:Mice; D008808:Mice, Inbred CBA; D010587:Phagocytosis; D013154:Spleen / Q000276:immunology; D013203:Staphylococcal Infections / Q000276:immunology* / Q000517:prevention & control; D013209:Staphylococcal Vaccines / Q000276:immunology*; D013211:Staphylococcus aureus / Q000276:immunology*; D013997:Time Factors
D018941:Antigens, CD19; D017252:CD3 Complex; D013209:Staphylococcal Vaccines