title: Low-grade myofibroblastic sarcoma of the oral cavity.
abstract: Two cases of low-grade myofibroblastic sarcoma (LGMS) are presented: one of lateral tongue, the other of lower buccal vestibule. LGMS represents a distinct atypical myofibroblastic tumor that occurs in several sites, primarily within the head and neck regions. A painless, enlarging mass is the most common clinical presentation, but a definitive diagnosis requires both histopathological and immunohistochemical analyses. Histologically, LGMS commonly presents as a cellular lesion composed of spindle-shaped tumor cells arranged primarily in fascicles with a diffusely infiltrative pattern. Immunohistochemically, LGMS shows positive staining for at least one myogenic marker, such as desmin, and muscle actin.
authors.affiliation: Unit of Oral Pathology and Medicine, Department of Medicine, Surgery and Dentistry, University of Milan, Milano, Italy. federica.demarosi@unimi.it
authors.forename: Frederica
authors.initials: F
authors.lastname: Demarosi
authors.forename: Alessandro
authors.initials: A
authors.lastname: Bay
authors.forename: Laura
authors.initials: L
authors.lastname: Moneghini
authors.forename: Antonio
authors.initials: A
authors.lastname: Carrassi
mesh_terms: D005260:Female; D006801:Humans; D008297:Male; D008339:Mandibular Neoplasms / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D009379:Neoplasms, Muscle Tissue / Q000473:pathology* / Q000601:surgery; D014062:Tongue Neoplasms / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome