Effects of ranibizumab on exudative disciform scars.
OBJECTIVE
To evaluate the effect of intravitreal ranibizumab in patients with leaking disciform scars.


METHODS
In this retrospective case series, 31 eyes received one or two ranibizumab injections for treatment of choroidal neovascularization. Visual acuity, central retinal thickness, and macular volume were measured prior to injection and at 1-month follow-up.


RESULTS
After one injection (n = 31), mean optical coherence tomography (OCT) central foveal thickness decreased from 317 to 242 microm (P = .00016). Mean OCT macular volume decreased from 7.89 to 6.80 mm3 (P = .00019). After two injections (n = 12), mean OCT central foveal thickness decreased from 310 to 248 microm following the second injection (P = .04). Mean OCT macular volume decreased from 7.80 to 6.43 mm3 at 1-month follow-up after a second injection (P = .006). There was no significant change in visual acuity after injections.


CONCLUSIONS
In the short-term, ranibizumab decreases the leakage associated with choroidal neovascularization in chronic macular degeneration.
Ahmad
Fatima K
FK
Harvard Medical School, Boston, Massachusetts, USA.
Morley
Michael G
MG
Berry
Anna
A
Wiegand
Torsten W
TW
Heier
Jeffrey S
JS
Morley
Eleanor F
EF
Sanguansak
Thuss
T
Topping
Trexler M
TM
Frederick
Albert R
AR
Sang
Delia N
DN
Hughes
Mark S
MS
Cleary
Tina S
TS
D000368:Aged; D000369:Aged, 80 and over; D020533:Angiogenesis Inhibitors / Q000627:therapeutic use*; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D061067:Antibodies, Monoclonal, Humanized; D020256:Choroidal Neovascularization / Q000175:diagnosis / Q000188:drug therapy*; D005122:Exudates and Transudates; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007267:Injections; D008268:Macular Degeneration / Q000175:diagnosis / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D000069579:Ranibizumab; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence; D016896:Treatment Outcome; D042461:Vascular Endothelial Growth Factor A / Q000037:antagonists & inhibitors; D014792:Visual Acuity; D014822:Vitreous Body
D020533:Angiogenesis Inhibitors; D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D042461:Vascular Endothelial Growth Factor A; D000069579:Ranibizumab