title: Plasma levels of C-reactive protein and interleukin-10 predict late coronary in-stent restenosis 6 months after elective stenting.
abstract: BACKGROUND
  In-stent restenosis (ISR) is one of the major limitations of percutaneous coronary intervention (PCI).
  
  
  OBJECTIVE
  To evaluate the relationship between the levels of hs-CRP, IL-6, IL-10 and intimal hyperplasia six months after coronary bare metal stent (BMS) implantation.
  
  
  METHODS
  The study population consisted of 73 consecutive patients who underwent bare metal stent implantation into narrowed coronary segments. A total of 74 stents were implanted. Angiographic study after six months, together with evaluation of serum level of IL-6 (pg/ml), IL-10 (pg/ml), hs-CRP (microg/ml), fasting insulin (microIU/ml) and glucose (mg%) was performed. Insulin sensitivity was calculated using the HOMA-IR formula. The QCA analysis of stented segments was performed at baseline, after intervention and at six-month follow-up.
  
  
  RESULTS
  Restenosis at six months occurred in 10 patients (13.7%). The mean % diameter stenosis at follow-up was 27.8 +/- 19% and late loss was 0.81 +/- 0.6 mm. We found a correlation between late loss and serum hs-CRP, IL-6 and IL-10 concentration. There was no correlation between the lipid profiles, insulin levels and HOMA-IR and re-narrowing of the stented segments. Patients with restenosis were characterised by significantly higher serum concentration of CRP (2.04 +/- 3.4 vs. 10.38 +/- 6.7 microg/ml, p = 0.0036), IL-6 (14.98 +/- 8.3 vs. 5.70 +/- 5.5 pg/ml, p = 00062), and fasting glucose (184.0 +/- 50.5 vs. 107.5 +/- 40.4 mg%, p = 0.0051), as well as lower IL-10 levels (1.25 +/- 0.6 vs. 4.85 +/- 4.9 pg/ml, p = 0.0000). The ROC analysis indicated that CRP (> 2.86 microg/ml), IL-6 (> 6.24 pg/ml) and IL-10 (< 1.7 pg/ml) values predicted the restenosis with reasonable accuracy. A multiple logistic regression model identified CRP and IL-10 levels as independent predictors of restenosis.
  
  
  CONCLUSIONS
  We demonstrated that elevated inflammatory markers 6 months after PCI are associated with late angiographic in-stent restenosis.
authors.affiliation: III Klinika Kardiologii, Slaski Uniwersytet Medyczny, Górnoślaski Ośrodek Kardiologii, ul. Ziołowa 47, 40-635 Katowice, Poland. olek@gronet.pl
authors.forename: Aleksander
authors.initials: A
authors.lastname: Zurakowski
authors.forename: Wojciech
authors.initials: W
authors.lastname: Wojakowski
authors.forename: Tadeusz
authors.initials: T
authors.lastname: Dzielski
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Milewski
authors.forename: Kinga
authors.initials: K
authors.lastname: Gościńska-Bis
authors.forename: Michał
authors.initials: M
authors.lastname: Tendera
authors.forename: Paweł
authors.initials: P
authors.lastname: Buszman
mesh_terms: D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D017023:Coronary Angiography; D003327:Coronary Disease / Q000628:therapy; D023903:Coronary Restenosis / Q000097:blood* / Q000000981:diagnostic imaging*; D017558:Elective Surgical Procedures; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D015607:Stents
chemical_list: D015415:Biomarkers; D016753:Interleukin-10; D002097:C-Reactive Protein