title: Practical synthesis of linear alpha-iodo/bromo-alpha,beta-unsaturated aldehydes/ketones from propargylic alcohols via Au/Mo bimetallic catalysis.
abstract: An efficient synthesis of alpha-iodo/bromo-alpha,beta-unsaturated aldehydes/ketones directly from propargylic alcohols is described. This reaction is catalyzed collaboratively by two metal complexes, Ph(3)PAuNTf(2) and MoO(2)(acac)(2), and Ph(3)PO as an additive helps suppress undesired enone/enal formation. Notable features of this method include low catalyst loadings, mild reaction conditions, and mostly good to excellent diastereoselectivity. In comparison with our previously developed method based on propargylic acetate substrates, this chemistry omits the need to prepare acetate derivatives and, moreover, has a much broader substrate scope.
authors.affiliation: Department of Chemistry, University of Nevada, Reno, Nevada 89557, USA.
authors.forename: Longwu
authors.initials: L
authors.lastname: Ye
authors.forename: Liming
authors.initials: L
authors.lastname: Zhang