title: Formulation and evaluation of floating, pulsatile, multiparticulates using pH-dependent swellable polymers.
abstract: The objective of this study was to develop a floating, pulsatile, multiparticulate drug delivery system intended for chronopharmacotherapy of arthritis. The floating pulsatile drug delivery has the advantage that a drug can be released in the upper gastrointestinal tract after a definite time period of no drug release, i.e. lag time. Cross-linked beads were prepared using low methoxylated pectin (LM104AS), sodium alginate, and low methoxylated pectin (LM104AS) along with sodium alginate by acid- base reaction during ionotropic gelation. Beads were dried in oven at 50 degrees C for 4 h. Aceclofenac was used as a model drug for encapsulation. Drug loaded multiparticulates were subjected to various characterization and evaluation parameters like entrapment efficiency, surface topography, size analysis and in vitro release study. It was found that calcium pectinate beads show maximum drug entrapment. Hence, pectin containing formulation was further studied for buoyancy, DSC and radio imaging study. Drug release study was performed in acidic environment using pH 1.2 buffer solution for 6 h and then at 7.4 pH for 60 min. The total drug release ranges from 5-10% and 90-94% in acidic and basic media, respectively.
authors.affiliation: Department of Pharmaceutics, R.C. Patel College of Pharmacy, Karvand Naka, Shirpur-425405, Maharashtra, India.
authors.forename: Madhuri
authors.initials: M
authors.lastname: Gaikwad
authors.forename: Veena S
authors.initials: VS
authors.lastname: Belgamwar
authors.forename: Avinash
authors.initials: A
authors.lastname: Tekade
authors.forename: Surendra
authors.initials: S
authors.lastname: Gattani
authors.forename: Sanjay
authors.initials: S
authors.lastname: Surana
mesh_terms: D000464:Alginates / Q000737:chemistry; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000737:chemistry; D001168:Arthritis / Q000188:drug therapy; D002152:Calorimetry, Differential Scanning; D019454:Chronotherapy / Q000379:methods; D003432:Cross-Linking Reagents / Q000737:chemistry; D003692:Delayed-Action Preparations; D004008:Diclofenac / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D010368:Pectins / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D020551:Pulse Therapy, Drug; D013997:Time Factors
chemical_list: D000464:Alginates; D000894:Anti-Inflammatory Agents, Non-Steroidal; D003432:Cross-Linking Reagents; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D006603:Hexuronic Acids; D011108:Polymers; D004008:Diclofenac; D010368:Pectins; D020723:Glucuronic Acid; C056498:aceclofenac