title: [Effect of preliminary medication on oxaliplatin hypersensitivity].
abstract: Oxaliplatin therapy is a standard treatment for advanced colorectal cancer, and oxaliplatin hypersensitivity is one of its side effects that should be particularly considered. In the present study, we observed a decrease in the incidence of oxaliplatin hypersensitivity since the introduction of preliminary medication involving the administration of escalated doses of steroids and the use of antihistamine agents. From the medical economics perspective, although the costs of the preliminary medication were generated, those for the treatment of oxaliplatin hypersensitivity, which were higher than the total cost of the preliminary medication, needed to be generated for all patients. Introduction of preliminary medication decreased the overall cost, since the medication decreased the incidence of hypersensitivity. Therefore, preliminary medication was recognized to be effective from the perspective of medical economics. The preliminary medication we introduced contributed to a safe, cost-effective, and high-quality treatment for advanced colorectal cancer by preventing oxaliplatin hypersensitivity.
authors.affiliation: Dept. of Pharmacy, Hirosaki University Hospital.
authors.forename: Junya
authors.initials: J
authors.lastname: Sato
authors.forename: Kazufumi
authors.initials: K
authors.lastname: Terui
authors.forename: Makoto
authors.initials: M
authors.lastname: Hayakari
mesh_terms: D000553:Ambulatory Care; D000970:Antineoplastic Agents / Q000009:adverse effects*; D015179:Colorectal Neoplasms / Q000188:drug therapy; D003362:Cost-Benefit Analysis; D004342:Drug Hypersensitivity / Q000191:economics / Q000517:prevention & control*; D006633:Histamine Antagonists / Q000008:administration & dosage / Q000191:economics; D006801:Humans; D009944:Organoplatinum Compounds / Q000009:adverse effects*; D000077150:Oxaliplatin; D011292:Premedication / Q000191:economics; D013256:Steroids / Q000008:administration & dosage
chemical_list: D000970:Antineoplastic Agents; D006633:Histamine Antagonists; D009944:Organoplatinum Compounds; D013256:Steroids; D000077150:Oxaliplatin