Stability of piritramide in patient-controlled analgesia (PCA) solutions.
For patient controlled analgesia, syringes with solutions of 1.5 mg/ml piritramide in 0.9% aqueous sodium chloride are used. The physical and chemical stability for dilutions of the commercially available preparation of piritramide is limited up to 72 hours by the manufacturer. Since application duration for patient-controlled analgesia can exceed that limited time, stability was investigated by HPLC. Our results show that these solutions are chemically stable over a time period of 60 days.
Remane
D
D
Institute of Pharmacy, Faculty of Medicine, Friedrich-Schiller-University, Jena, Germany.
Scriba
G
G
Meissner
W
W
Hartmann
M
M
D016058:Analgesia, Patient-Controlled; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D004355:Drug Stability; D007262:Infusions, Intravenous; D019999:Pharmaceutical Solutions; D010892:Pirinitramide / Q000008:administration & dosage / Q000032:analysis*; D012015:Reference Standards; D015203:Reproducibility of Results
D000701:Analgesics, Opioid; D019999:Pharmaceutical Solutions; D010892:Pirinitramide