[Refractory idiopathic thrombocytopenic purpura following influenza vaccination].
A 79-year-old man was admitted to our hospital due to generalized petechiae. Four days before onset, the patient had been administered an influenza vaccine. The platelet count, which was 13.6x10(4)/microl before vaccination, decreased to 0.4x10(4)/microl. Although he received various treatments, such as high-dose immunoglobulin therapy, prednisolone, and splenectomy, they were ineffective. Three weeks after CyA administration, the platelet count began to increase. Eighty days after administration, it reached 3.0-5.0x10(4)/microl. Thrombocytopenia after influenza vaccination is rare, and no refractory case has been previously reported.
Tsuji
Takahiro
T
Kumamoto City Hospital.
Yamasaki
Hiroshi
H
Tsuda
Hiroyuki
H
D000368:Aged; D016572:Cyclosporine / Q000008:administration & dosage; D006801:Humans; D007136:Immunoglobulins / Q000008:administration & dosage; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D007252:Influenza Vaccines / Q000009:adverse effects*; D008297:Male; D011239:Prednisolone / Q000008:administration & dosage; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D013156:Splenectomy; D016896:Treatment Outcome
D007136:Immunoglobulins; D007166:Immunosuppressive Agents; D007252:Influenza Vaccines; D016572:Cyclosporine; D011239:Prednisolone