Controllable stereoselective synthesis of trisubstituted alkenes by a catalytic three-component reaction of terminal alkynes, benzylic alcohols, and simple arenes.
The acid-catalyzed three-component reaction of terminal alkynes, benzylic alcohols, and simple arenes provides convenient and atom-economic access to an array of both Z- and E-isomers of trisubstituted alkenes with excellent stereoselectivity by switching reaction temperature and acidic catalysts.
Li
Hai-Hua
HH
Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China.
Jin
Yin-Huan
YH
Wang
Jie-Qi
JQ
Tian
Shi-Kai
SK
D000475:Alkenes / Q000138:chemical synthesis* / Q000737:chemistry; D000480:Alkynes / Q000737:chemistry*; D001592:Benzyl Alcohols / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D013237:Stereoisomerism
D000475:Alkenes; D000480:Alkynes; D001592:Benzyl Alcohols