Hydrogen sulfide-induced hypometabolism prevents renal ischemia/reperfusion injury.
Hydrogen sulfide (H(2)S) can induce a hypometabolic, hibernation-like state in mammals when given in subtoxic concentrations. Pharmacologically reducing the demand for oxygen is a promising strategy to minimize unavoidable hypoxia-induced injury such as ischemia/reperfusion injury during renal transplantation. Here we show that H(2)S reduces metabolism in vivo, ex vivo, and in vitro. Furthermore, we demonstrate the beneficial effects of H(2)S-induced hypometabolism in a model of bilateral renal ischemia/reperfusion injury using three different treatment strategies. The results demonstrate striking protective effects on survival, renal function, apoptosis, and inflammation. A hypometabolic state induced by H(2)S might have therapeutic potential to protect kidneys that suffer from hypoxia.
Bos
Eelke M
EM
Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. e.m.bos@path.umcg.nl
Leuvenink
Henri G D
HG
Snijder
Pauline M
PM
Kloosterhuis
Niels J
NJ
Hillebrands
Jan-Luuk
JL
Leemans
Jaklien C
JC
Florquin
Sandrine
S
van Goor
Harry
H
D000222:Adaptation, Physiological / Q000502:physiology; D000393:Air Pollutants / Q000494:pharmacology; D000818:Animals; D004195:Disease Models, Animal; D004734:Energy Metabolism / Q000187:drug effects; D006605:Hibernation / Q000502:physiology; D006862:Hydrogen Sulfide / Q000494:pharmacology*; D007674:Kidney Diseases / Q000378:metabolism* / Q000517:prevention & control*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D051381:Rats; D011916:Rats, Inbred F344; D015427:Reperfusion Injury / Q000378:metabolism* / Q000517:prevention & control*
D000393:Air Pollutants; D006862:Hydrogen Sulfide