title: Region of difference 1 in nontuberculous Mycobacterium species adds a phylogenetic and taxonomical character.
abstract: The esat-6 and cfp-10 genes are essential for virulence in Mycobacterium tuberculosis. Among nontuberculous mycobacteria, we found these genes only in M. kansasii, M. szulgai, M. marinum, and M. riyadhense, with unique sequences. This adds a phylogenetic and taxonomical characteristic and may represent a virulence factor for nontuberculous mycobacteria.
authors.affiliation: National Mycobacteria Reference Laboratory, Laboratories for Infectious Diseases and Perinatal Screening, National Institute for Public Health and the Environment, Bilthoven, The Netherlands. jakko.van.ingen@rivm.nl
authors.forename: Jakko
authors.initials: J
authors.lastname: van Ingen
authors.forename: Rina
authors.initials: R
authors.lastname: de Zwaan
authors.forename: Richard
authors.initials: R
authors.lastname: Dekhuijzen
authors.forename: Martin
authors.initials: M
authors.lastname: Boeree
authors.forename: Dick
authors.initials: D
authors.lastname: van Soolingen
mesh_terms: D000942:Antigens, Bacterial / Q000235:genetics* / Q000378:metabolism; D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism; D015373:Bacterial Typing Techniques; D015964:Gene Expression Regulation, Bacterial; D006801:Humans; D008969:Molecular Sequence Data; D009165:Mycobacterium Infections, Nontuberculous / Q000382:microbiology; D019909:Mycobacterium kansasii / Q000145:classification / Q000235:genetics / Q000472:pathogenicity; D019910:Mycobacterium marinum / Q000145:classification / Q000235:genetics / Q000472:pathogenicity; D009170:Nontuberculous Mycobacteria / Q000145:classification / Q000235:genetics / Q000472:pathogenicity; D010802:Phylogeny; D017422:Sequence Analysis, DNA; D014774:Virulence; D037521:Virulence Factors / Q000235:genetics* / Q000378:metabolism
chemical_list: D000942:Antigens, Bacterial; D001426:Bacterial Proteins; C117940:CFP-10 protein, Mycobacterium tuberculosis; C093276:ESAT-6 protein, Mycobacterium tuberculosis; D037521:Virulence Factors