title: Systematic review and meta-analysis of the prevalence of irritable bowel syndrome in individuals with dyspepsia.
abstract: OBJECTIVE
  Dyspepsia and irritable bowel syndrome (IBS) are common conditions that can coexist in patients. We performed a systematic review and meta-analysis to estimate prevalence of IBS in dyspepsia.
  
  
  METHODS
  Relevant articles published through August 2008 were identified from MEDLINE and EMBASE literature searches (23,457 citations). Eligible studies included adults recruited from the community, the workplace, blood donation or screening clinics, and family physician offices or internal medicine clinics. Selected studies reported prevalence of dyspepsia and IBS within the same population. The prevalence of IBS in subjects with and without dyspepsia was pooled for all studies and compared. Odds ratios (OR) and confidence intervals (CI) were calculated. The degree of overlap between dyspepsia and IBS was determined.
  
  
  RESULTS
  Of 239 papers evaluated, 150 reported prevalence of dyspepsia and 19 (involving 18,173 subjects) reported the proportion of subjects with IBS within the same population. The prevalence of dyspepsia was 27% (95% CI, 23%-31%). The prevalence of IBS in subjects with dyspepsia was 37% (95% CI, 30%-45%) compared with 7% (95% CI, 5%-10%) in those without. The pooled OR for IBS in subjects with dyspepsia was 8 (95% CI, 5.74-11.16). The degree of overlap between the 2 conditions varied from 15% to 42%, depending on diagnostic criteria used for each.
  
  
  CONCLUSIONS
  Individuals with dyspepsia have an 8-fold increase in prevalence of IBS compared with the population. The strength of the association suggests common pathogenic mechanisms. Dyspeptic patients should be assessed routinely for IBS.
authors.affiliation: Gastroenterology Division, McMaster University, Health Sciences Centre, Hamilton, Ontario, Canada. alexf12399@yahoo.com
authors.forename: Alexander C
authors.initials: AC
authors.lastname: Ford
authors.forename: Avantika
authors.initials: A
authors.lastname: Marwaha
authors.forename: Allen
authors.initials: A
authors.lastname: Lim
authors.forename: Paul
authors.initials: P
authors.lastname: Moayyedi
mesh_terms: D015897:Comorbidity; D004415:Dyspepsia / Q000150:complications* / Q000453:epidemiology*; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000150:complications* / Q000453:epidemiology*; D015995:Prevalence