title: Expression of CD4(+)CD25(high)CD127(low/-) regulatory T cells in transitional cell carcinoma patients and its significance.
abstract: To evaluate the expressions of CD4(+)CD25(high)CD127(low/-) regulatory T cells (Tregs) in peripheral blood from patients with transitional cell carcinoma (TCC) in urinary system, we investigated the proportion of Treg population in CD4(+) T from 93 patients with TCC, 38 with benign urinary diseases, and 37 healthy subjects by using flow cytometric analysis and analyzing different clinicopathologic characteristics and the changes before and after operation. We found that the proportion of Treg in peripheral blood from patients with TCC was significantly increased as compared with the other two groups. There was a strong correlation between the proportion of Treg and tumor recurrence, quantity, lymph node metastasis (P<0.01), as well as pathological stage; no correlation was found between the proportion of Treg and clinical TNM stage (P>0.05). The proportion of Treg was also different before and after operation (P<0.05). This suggest that CD4(+)CD25(+)CD127(low/-) regulatory T cells may be responsible for immune suppression in TCC patients. The resection of tumor can decrease the proportion of Treg in peripheral blood.
authors.affiliation: Department of Urology, Friendship Hospital, Capital Medical University, Beijing 100050, China.
authors.forename: Xi
authors.initials: X
authors.lastname: Zhu
authors.forename: Lin-Lin
authors.initials: LL
authors.lastname: Ma
authors.forename: Tian
authors.initials: T
authors.lastname: Ye
mesh_terms: D000368:Aged; D015703:Antigens, CD / Q000276:immunology*; D014408:Biomarkers, Tumor / Q000097:blood*; D015704:CD4 Antigens / Q000276:immunology; D002295:Carcinoma, Transitional Cell / Q000097:blood / Q000276:immunology* / Q000473:pathology; D005260:Female; D005434:Flow Cytometry / Q000379:methods; D006801:Humans; D053645:Interleukin-2 Receptor alpha Subunit / Q000276:immunology; D053699:Interleukin-7 Receptor alpha Subunit / Q000276:immunology; D008297:Male; D008875:Middle Aged; D050378:T-Lymphocytes, Regulatory / Q000276:immunology* / Q000473:pathology; D014571:Urologic Neoplasms / Q000097:blood / Q000276:immunology* / Q000473:pathology
chemical_list: D015703:Antigens, CD; D014408:Biomarkers, Tumor; D015704:CD4 Antigens; C508017:IL2RA protein, human; D053645:Interleukin-2 Receptor alpha Subunit; D053699:Interleukin-7 Receptor alpha Subunit