MRI-guided vacuum-assisted breast biopsy: a phantom and patient evaluation of targeting accuracy.
OBJECTIVE
To determine the spatial localization errors of magnetic resonance imaging (MRI)-guided core biopsy for breast lesions using the handheld vacuum-assisted core biopsy device in phantoms and patients.


METHODS
Biopsies were done using a 10-gauge handheld vacuum-assisted core biopsy system (Vacora, Bard, AZ, USA) on a 1.5T MRI scanner (Philips Achieva, Best, The Netherlands). A standardized biopsy localization protocol was followed by trained operators for multiplanar planning of the biopsy on a separate workstation. Biopsy localization errors were determined as the distance from needle tip to center of the target in three dimensions.


RESULTS
Twenty MRI-guided biopsies of phantoms were performed by three different operators. The biopsy target mean size was 6.8 +/- 0.6 mm. The overall mean three-dimensional (3D) biopsy targeting error was 4.4 +/- 2.9 mm. Thirty-two MRI breast biopsies performed in 22 patients were reviewed. The lesion mean size was 10.5 +/- 9.4 mm. The overall mean 3D localization error was 5.7 +/- 3.0 mm. No significant differences between phantom and patients biopsy errors were found (P > 0.5).


CONCLUSIONS
MRI-guided handheld vacuum-assisted core biopsy device shows good targeting accuracy and should allow localization of lesions to within approximately 5 to 6 mm.
El Khouli
Riham H
RH
Department of Radiology and Imaging Sciences, National Institutes of Health, Bethesda, Maryland 20892, USA.
Macura
Katarzyna J
KJ
Barker
Peter B
PB
Elkady
Laila M
LM
Jacobs
Michael A
MA
Vogel-Claussen
Jens
J
Bluemke
David A
DA
D001706:Biopsy / Q000379:methods*; D001943:Breast Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D053783:Magnetic Resonance Imaging, Interventional / Q000379:methods*; D008875:Middle Aged; D019047:Phantoms, Imaging; D012189:Retrospective Studies; D014618:Vacuum