title: COMT val108/158 met genotype affects neural but not cognitive processing in healthy individuals.
abstract: The relationship between cognition and a functional polymorphism in the catechol-O-methlytransferase (COMT) gene, val108/158met, is one of debate in the literature. Furthermore, based on the dopaminergic differences associated with the COMT val108/158met genotype, neural differences during cognition may be present, regardless of genotypic differences in cognitive performance. To investigate these issues the current study aimed to 1) examine the effects of COMT genotype using a large sample of healthy individuals (n = 496-1218) and multiple cognitive measures, and using a subset of the sample (n = 22), 2) examine whether COMT genotype effects medial temporal lobe (MTL) and frontal activity during successful relational memory processing, and 3) investigate group differences in functional connectivity associated with successful relational memory processing. Results revealed no significant group difference in cognitive performance between COMT genotypes in any of the 19 cognitive measures. However, in the subset sample, COMT val homozygotes exhibited significantly decreased MTL and increased prefrontal activity during both successful relational encoding and retrieval, and reduced connectivity between these regions compared with met homozygotes. Taken together, the results suggest that although the COMT val108/158met genotype has no effect on cognitive behavioral measures in healthy individuals, it is associated with differences in neural process underlying cognitive output.
authors.affiliation: Center for Cognitive Neuroscience, Duke University, Durham, NC 27708, USA. nad12@psu.edu
authors.forename: Nancy A
authors.initials: NA
authors.lastname: Dennis
authors.forename: Anna C
authors.initials: AC
authors.lastname: Need
authors.forename: Kevin S
authors.initials: KS
authors.lastname: LaBar
authors.forename: Sheena
authors.initials: S
authors.lastname: Waters-Metenier
authors.forename: Elizabeth T
authors.initials: ET
authors.lastname: Cirulli
authors.forename: James
authors.initials: J
authors.lastname: Kragel
authors.forename: David B
authors.initials: DB
authors.lastname: Goldstein
authors.forename: Roberto
authors.initials: R
authors.lastname: Cabeza
mesh_terms: D000293:Adolescent; D000328:Adult; D001931:Brain Mapping; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D005260:Female; D055106:Genome-Wide Association Study / Q000379:methods; D005838:Genotype; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008568:Memory / Q000502:physiology*; D008715:Methionine / Q000235:genetics*; D008875:Middle Aged; D009483:Neuropsychological Tests; D010100:Oxygen / Q000097:blood; D017397:Prefrontal Cortex / Q000098:blood supply / Q000502:physiology*; D013702:Temporal Lobe / Q000098:blood supply / Q000502:physiology*; D014633:Valine / Q000235:genetics*; D055815:Young Adult
chemical_list: D008715:Methionine; D002394:Catechol O-Methyltransferase; D014633:Valine; D010100:Oxygen