title: A microprocessor-controlled tracheal insufflation-assisted total liquid ventilation system.
abstract: A prototype time cycled, constant volume, closed circuit perfluorocarbon (PFC) total liquid ventilator system is described. The system utilizes microcontroller-driven display and master control boards, gear motor pumps, and three-way solenoid valves to direct flow. A constant tidal volume and functional residual capacity (FRC) are maintained with feedback control using end-expiratory and end-inspiratory stop-flow pressures. The system can also provide a unique continuous perfusion (bias flow, tracheal insufflation) through one lumen of a double-lumen endotracheal catheter to increase washout of dead space liquid. FRC and arterial blood gases were maintained during ventilation with Rimar 101 PFC over 2-3 h in normal piglets and piglets with simulated pulmonary edema induced by instillation of albumin solution. Addition of tracheal insufflation flow significantly improved the blood gases and enhanced clearance of instilled albumin solution during simulated edema.
authors.affiliation: Department of Physiology, University of South Alabama, MSB 3074, Mobile, AL 36688, USA. jparker@usouthal.edu
authors.forename: James Courtney
authors.initials: JC
authors.lastname: Parker
authors.forename: Adel
authors.initials: A
authors.lastname: Sakla
authors.forename: Francis M
authors.initials: FM
authors.lastname: Donovan
authors.forename: David
authors.initials: D
authors.lastname: Beam
authors.forename: Annu
authors.initials: A
authors.lastname: Chekuri
authors.forename: Mohammad
authors.initials: M
authors.lastname: Al-Khatib
authors.forename: Charles R
authors.initials: CR
authors.lastname: Hamm
authors.forename: Fabien G
authors.initials: FG
authors.lastname: Eyal
mesh_terms: D000818:Animals; D002245:Carbon Dioxide / Q000097:blood; D004867:Equipment Design; D007327:Insufflation / Q000295:instrumentation* / Q000379:methods; D021061:Liquid Ventilation / Q000295:instrumentation* / Q000379:methods; D008838:Microcomputers; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D011654:Pulmonary Edema / Q000628:therapy; D034421:Sus scrofa
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen