title: Intralymphatic atypical T-cell proliferation in a cutaneous hemangioma.
abstract: We report an unusual case of atypical T-cell proliferation involving the lymphatic vessels within a cutaneous hemangioma from an elderly woman. Despite the blastic morphology, the CD4 restricted phenotype and the very high proliferation index, the clinical presentation (single skin lesion in a healthy woman), the benign clinical course and the absence of T-cell receptor (TCR) clonal rearrangement favored a reactive nature of the process. Since the atypical cells showed an effector/memory-like regulatory T-phenotype (CD45RO+, CD25+ and FOXp3+), expressed the migration-associated molecule CCR7 and were exclusively located within podoplanin+ lymphatic vessels, we speculate that the process might reflect an unusual local immune response, with migration of T-cells to draining lymph nodes.
authors.affiliation: Department of Pathology, University-Spedali Civili of Brescia, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Ardighieri
authors.forename: Silvia
authors.initials: S
authors.lastname: Lonardi
authors.forename: William
authors.initials: W
authors.lastname: Vermi
authors.forename: Daniela
authors.initials: D
authors.lastname: Medicina
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Cerroni
authors.forename: Fabio
authors.initials: F
authors.lastname: Facchetti
mesh_terms: D000368:Aged; D049109:Cell Proliferation; D005260:Female; D051858:Forkhead Transcription Factors / Q000276:immunology; D006391:Hemangioma / Q000276:immunology* / Q000473:pathology; D006801:Humans; D008198:Lymph Nodes / Q000276:immunology* / Q000473:pathology; D008213:Lymphocyte Activation / Q000276:immunology; D011948:Receptors, Antigen, T-Cell / Q000276:immunology; D012878:Skin Neoplasms / Q000276:immunology* / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology* / Q000473:pathology
chemical_list: D051858:Forkhead Transcription Factors; D011948:Receptors, Antigen, T-Cell