title: Giant subcortical heterotopia involving the temporo-parieto-occipital region: a challenging cause of drug-resistant epilepsy.
abstract: The clinical, radiological, neurophysiological and neuropsychological findings of three patients with giant subcortical heterotopia are reported. All patients experienced psychomotor and behaviour improvement after surgery. Two subjects are seizure-free after complete excision of the heterotopia; the third patient significantly improved following subtotal removal (Engel's class II). Patients affected by giant subcortical heterotopias can have a favourable prognosis after the surgical removal of the malformation, even following long-lasting epilepsy.
authors.affiliation: Department of Pediatric Neurosurgery, Catholic University Medical School, Largo A. Gemelli, 8, 00168 Rome, Italy. federicanovegno@hotmail.it
authors.forename: Federica
authors.initials: F
authors.lastname: Novegno
authors.forename: Domenica
authors.initials: D
authors.lastname: Battaglia
authors.forename: Daniela
authors.initials: D
authors.lastname: Chieffo
authors.forename: Paolo
authors.initials: P
authors.lastname: Frassanito
authors.forename: Chiara
authors.initials: C
authors.lastname: Leoni
authors.forename: Gianpiero
authors.initials: G
authors.lastname: Tamburrini
authors.forename: Luca
authors.initials: L
authors.lastname: Massimi
authors.forename: Tommaso
authors.initials: T
authors.lastname: Tartaglione
authors.forename: Concezio
authors.initials: C
authors.lastname: Di Rocco
authors.forename: Francesco
authors.initials: F
authors.lastname: Guzzetta
mesh_terms: D000293:Adolescent; D001931:Brain Mapping; D002675:Child, Preschool; D054221:Classical Lissencephalies and Subcortical Band Heterotopias / Q000503:physiopathology / Q000601:surgery*; D004569:Electroencephalography; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests; D009778:Occipital Lobe / Q000503:physiopathology; D010296:Parietal Lobe / Q000503:physiopathology; D012640:Seizures / Q000503:physiopathology / Q000601:surgery*; D013702:Temporal Lobe / Q000503:physiopathology; D016896:Treatment Outcome