[Biochemical markers of bone turnover. New aspect. Nitric oxide synthase and bone metabolism].
It remains to be determined the role of the nitric oxide synthase (NOS) system in bone metabolism. We addressed this point in mice with complete disruption of the NOS system (triply n/i/eNOS(-/-) mice) that we have recently developed, and clarified that the triply NOS( - / - ) mice manifested increased bone mineral density and accelerated bone turnover in vivo. These results provide the first direct evidence that the entire NOS system plays an important role in the regulation of bone metabolism.
Sabanai
Ken
K
Department of Orthopaedic Surgery, Tohoku Rosai Hospital/Department of Orthopaedic Surgery, School of Medicine University of Occupational and Enviromental Health.
Tsutsui
Masato
M
Sakai
Akinori
A
Nakamura
Toshitaka
T
Shimokawa
Hiroaki
H
Yanagihara
Nobuyuki
N
D000818:Animals; D015519:Bone Density / Q000502:physiology*; D016723:Bone Remodeling / Q000502:physiology; D001862:Bone Resorption; D001842:Bone and Bones / Q000378:metabolism*; D006706:Homeostasis; D006801:Humans; D051379:Mice; D019001:Nitric Oxide Synthase / Q000502:physiology*; D010012:Osteogenesis; D012084:Renin-Angiotensin System / Q000502:physiology
D019001:Nitric Oxide Synthase