title: [Analysis of prognostic factors in 300 colorectal cancer patients with liver metastases].
abstract: OBJECTIVE
  To analyse the clinical characteristics and potential prognostic factors of colorectal cancer patients with liver metastases.
  
  
  METHODS
  The clinical and pathological data of 300 colorectal cancer patients with liver metastases were retrospectively reviewed and analyzed.
  
  
  RESULTS
  The median survival time of these patients was 19.0 months. The 1-, 2- and 5-year survival rates after liver metastases were 79.0%, 29.0% and 3.0%, respectively. Univariate analysis revealed that performance status (KPS), histological grading, primary tumor, N status, lymphatic and vascular invasion, stage at diagnosis, the number, size and distribution of liver metastases and other accompanied metastases were prognostic factors. Multivariate analysis showed that KPS, lymphatic and vascular invasion, the number and size of liver metastases were independent prognostic factors of colorectal cancer with liver metastases.
  
  
  CONCLUSIONS
  Performance status, lymphatic and vascular invasion, the number and size of liver metastases are independent prognostic factors of colorectal cancer with liver metastases.
authors.affiliation: Department of Medical Oncology, Chinese Academy of Medical Sciences, Beijing 100021, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Fang
authors.forename: Xing-yuan
authors.initials: XY
authors.lastname: Wang
authors.forename: Jin-wan
authors.initials: JW
authors.lastname: Wang
authors.forename: Hong-gang
authors.initials: HG
authors.lastname: Zhang
authors.forename: Feng-yi
authors.initials: FY
authors.lastname: Feng
authors.forename: Yuan-kai
authors.initials: YK
authors.lastname: Shi
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy / Q000473:pathology / Q000556:secondary* / Q000601:surgery; D002288:Adenocarcinoma, Mucinous / Q000188:drug therapy / Q000473:pathology / Q000556:secondary / Q000601:surgery; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003110:Colonic Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy / Q000556:secondary* / Q000601:surgery; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009360:Neoplastic Cells, Circulating; D016016:Proportional Hazards Models; D012004:Rectal Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D012189:Retrospective Studies; D015996:Survival Rate; D047368:Tumor Burden; D055815:Young Adult