[Prognostic significance of tumor-associated macrophage infiltration in advanced epithelial ovarian carcinoma].
OBJECTIVE
Tumor-associated macrophage (TAM) infiltration promotes the progression of various malignancies. This study was to investigate the influence of TAM infiltration on the survival and prognosis of patients with ovarian cancer.


METHODS
The expression of CD68, a TAM-specific marker, in 67 specimens of ovarian cancer and 22 specimens of benign ovarian lesion was detected by SP immunohistochemistry to investigate the density of TAM. The correlation of TAM density to the prognosis of ovarian cancer was analyzed. Cox multivariate proportional hazard model was used to analyze prognostic factors of ovarian cancer.


RESULTS
Observing under x 400 lens, the mean density of TAM was significantly higher in ovarian cancer than in benign ovarian lesions (57.7 vs. 25.3 per vision field, p<0.01). The 5-year survival rate was significantly higher in low-density TAM group than in high-density TAM group of ovarian cancer patients (73.3% vs. 41.2%, p=0.01). Univariate analysis found that TAM infiltration was more obvious in serous carcinoma, moderately and poorly differentiated carcinoma and in patients aged >or=40 than in the counterparts. Multivariate analysis revealed that histological grade and TAM infiltration status are independent predictors for overall survival.


CONCLUSIONS
TAM infiltration is obvious in advanced ovarian cancer, which indicates poor prognosis.
Wan
Ting
T
State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, P. R. China.
Liu
Ji-Hong
JH
Zheng
Li-Min
LM
Cai
Mu-Yan
MY
Ding
Tong
T
D000230:Adenocarcinoma / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D000328:Adult; D000367:Age Factors; D000368:Aged; D015703:Antigens, CD / Q000378:metabolism*; D015214:Antigens, Differentiation, Myelomonocytic / Q000378:metabolism*; D000077216:Carcinoma, Ovarian Epithelial; D018282:Cystadenocarcinoma, Mucinous / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D018284:Cystadenocarcinoma, Serous / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008264:Macrophages / Q000378:metabolism / Q000473:pathology*; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D009375:Neoplasms, Glandular and Epithelial / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D010048:Ovarian Cysts / Q000378:metabolism / Q000473:pathology; D010051:Ovarian Neoplasms / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D016016:Proportional Hazards Models; D015996:Survival Rate; D000097382:CD68 Molecule
D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; C067980:CD68 antigen, human; D000097382:CD68 Molecule