title: Kimura's disease presenting with a giant suspensory tumor and associated with membranoproliferative glomerulonephritis.
abstract: Kimura's disease is a rare chronic inflammatory disease, which typically occurs in middle-aged Asian men. This benign lymphoproliferative disorder with tissue eosinophilia is clinically characterized by painless subcutaneous swelling or induration, affecting the head and neck region. Here we present a 42-year-old Japanese woman with a giant tumor on the right inguinal region. The tumor was diagnosed as Kimura's disease, because of massive infiltration of lymphoid follicle-forming lymphocytes and eosinophils with elevated serum immunoglobulin E and blood eosinophilia. She also had nephrotic syndrome histopathologically diagnosed as membranoproliferative glomerulonephritis (MPGN). Renal involvement is known as one of the associated conditions with Kimura's disease. The skin and renal diseases were successfully treated with corticosteroids and surgical removal of the mass.
authors.affiliation: Department of Dermatology, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, Fukuoka 807-8555, Japan. r-kabaji@med.uoeh-u.ac.jp
authors.forename: Rieko
authors.initials: R
authors.lastname: Kabashima
authors.forename: Kenji
authors.initials: K
authors.lastname: Kabashima
authors.forename: Shoko
authors.initials: S
authors.lastname: Mukumoto
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Hino
authors.forename: Yumi
authors.initials: Y
authors.lastname: Huruno
authors.forename: Naritoshi
authors.initials: N
authors.lastname: Kabashima
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Tokura
mesh_terms: D000328:Adult; D000796:Angiolymphoid Hyperplasia with Eosinophilia / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D015432:Glomerulonephritis, Membranoproliferative / Q000150:complications* / Q000188:drug therapy / Q000473:pathology*; D005938:Glucocorticoids / Q000627:therapeutic use; D006119:Groin / Q000473:pathology / Q000601:surgery; D006801:Humans; D009369:Neoplasms / Q000209:etiology / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D005938:Glucocorticoids