Synthesis, antimicrobial and antioxidant activities of substituted pyrazoles, isoxazoles, pyrimidine and thioxopyrimidine derivatives.
A new class of heterocycles, substituted pyrazoles, isoxazoles, pyrimidines, thioxopyrimidines were prepared from Michael adducts, 2-(1,2-diaroylethyl)malononitrile and 2-(1,2-diarylsulfonylethyl)malononitrile by cyclocondensation with appropriate nucleophiles. The lead compounds were screened for the antimicrobial and antioxidant activities.
Padmaja
A
A
Department of Chemistry, Sri Venkateswara University, Tirupati 517 502, Andhra Pradesh, India. adivireddyp@yahoo.co.in
Payani
T
T
Reddy
G Dinneswara
GD
Padmavathi
V
V
D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D005609:Free Radicals / Q000378:metabolism; D005658:Fungi / Q000187:drug effects; D007555:Isoxazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D009569:Nitric Oxide / Q000378:metabolism; D011720:Pyrazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D011743:Pyrimidines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
D000890:Anti-Infective Agents; D000975:Antioxidants; D005609:Free Radicals; D007555:Isoxazoles; D011720:Pyrazoles; D011743:Pyrimidines; D009569:Nitric Oxide