Sulindac inhibits canonical Wnt signaling by blocking the PDZ domain of the protein Dishevelled.
Lee
Ho-Jin
HJ
Department of Structural Biology, Stop 311, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105-3678, USA.
Wang
Nick X
NX
Shi
De-Li
DL
Zheng
Jie J
JJ
D048868:Adaptor Proteins, Signal Transducing / Q000737:chemistry / Q000378:metabolism*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D000072261:Dishevelled Proteins; D006801:Humans; D008958:Models, Molecular; D009687:Nuclear Proteins / Q000378:metabolism; D054731:PDZ Domains; D010750:Phosphoproteins / Q000737:chemistry / Q000378:metabolism*; D011485:Protein Binding; D015398:Signal Transduction / Q000187:drug effects*; D013467:Sulindac / Q000494:pharmacology*; D051153:Wnt Proteins / Q000378:metabolism*; D014981:Xenopus / Q000196:embryology / Q000378:metabolism
D048868:Adaptor Proteins, Signal Transducing; D000970:Antineoplastic Agents; D000072261:Dishevelled Proteins; D009687:Nuclear Proteins; D010750:Phosphoproteins; D051153:Wnt Proteins; C057979:nuclear protein B4, Xenopus laevis; D013467:Sulindac