[The role of RAD 51 gene polymorphism in patients with colorectal cancer in the Polish subpopulation].
DNA repair processes assure genomic integrity and play the crucial role in protecting against carcinogenic factors. Mutations in DNA repair genes, which code proteins engaged in repair processes, may lead to carcinogenesis and among others also to colorectal cancer development. RAD51 gene encodes a protein of DNA homologues recombination repair.


OBJECTIVE
To evaluate the role of RAD51 gene polymorphism in patients with colorectal cancer in Polish subpopulation Materials and methods. The studied group comprised 100 colorectal cancer patients (aged 57-75) and 236 age, sex-, age- and ethnicity-matched cancer-free controls. Genotypes were determined in DNA from peripheral blood lymphocytes by PCR-RFLP.


RESULTS
An association between colorectal cancer occurrence and the G/C variant of the 135 G/C RAD51 polymorphism was found (OR 2.45; 95% CI 1,45-4,14) (p > 0.05).


CONCLUSIONS
The G/C variant of the 135 G/C RAD51 polymorphism may be associated with the increased risk of colorectal cancer development.
Wiśniewska-Jarosińska
Maria
M
Medical University of Lodz, Department of Gastroenterology and Internal Diseases. gastro@achilles.wam.pl
Sliwińfski
Tomasz
T
Krupa
Renata
R
Stec-Michalska
Krystyna
K
Chojnacki
Jan
J
Błasiak
Janusz
J
D000368:Aged; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011044:Poland / Q000453:epidemiology; D011110:Polymorphism, Genetic; D051135:Rad51 Recombinase / Q000235:genetics*; D018570:Risk Assessment
C495153:RAD51 protein, human; D051135:Rad51 Recombinase