title: Humanized mice for modeling human infectious disease: challenges, progress, and outlook.
abstract: Over 800 million people worldwide are infected with hepatitis viruses, human immunodeficiency virus (HIV), and malaria, resulting in more than 5 million deaths annually. Here we discuss the potential and challenges of humanized mouse models for developing effective and affordable therapies and vaccines, which are desperately needed to combat these diseases.
authors.affiliation: Department of Cell Biology and Histology, Academic Medical Center of the University of Amsterdam, Amsterdam 1105 AZ, The Netherlands.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Legrand
authors.forename: Alexander
authors.initials: A
authors.lastname: Ploss
authors.forename: Rudi
authors.initials: R
authors.lastname: Balling
authors.forename: Pablo D
authors.initials: PD
authors.lastname: Becker
authors.forename: Chiara
authors.initials: C
authors.lastname: Borsotti
authors.forename: Nicolas
authors.initials: N
authors.lastname: Brezillon
authors.forename: Jennifer
authors.initials: J
authors.lastname: Debarry
authors.forename: Ype
authors.initials: Y
authors.lastname: de Jong
authors.forename: Hongkui
authors.initials: H
authors.lastname: Deng
authors.forename: James P
authors.initials: JP
authors.lastname: Di Santo
authors.forename: Stephanie
authors.initials: S
authors.lastname: Eisenbarth
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Eynon
authors.forename: Richard A
authors.initials: RA
authors.lastname: Flavell
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Guzman
authors.forename: Nicholas D
authors.initials: ND
authors.lastname: Huntington
authors.forename: Dina
authors.initials: D
authors.lastname: Kremsdorf
authors.forename: Michael P
authors.initials: MP
authors.lastname: Manns
authors.forename: Markus G
authors.initials: MG
authors.lastname: Manz
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Mention
authors.forename: Michael
authors.initials: M
authors.lastname: Ott
authors.forename: Chozhavendan
authors.initials: C
authors.lastname: Rathinam
authors.forename: Charles M
authors.initials: CM
authors.lastname: Rice
authors.forename: Anthony
authors.initials: A
authors.lastname: Rongvaux
authors.forename: Sean
authors.initials: S
authors.lastname: Stevens
authors.forename: Hergen
authors.initials: H
authors.lastname: Spits
authors.forename: Hélène
authors.initials: H
authors.lastname: Strick-Marchand
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Takizawa
authors.forename: Anja U
authors.initials: AU
authors.lastname: van Lent
authors.forename: Chengyan
authors.initials: C
authors.lastname: Wang
authors.forename: Kees
authors.initials: K
authors.lastname: Weijer
authors.forename: Tim
authors.initials: T
authors.lastname: Willinger
authors.forename: Patrick
authors.initials: P
authors.lastname: Ziegler
mesh_terms: D000818:Animals; D035843:Biomedical Research / Q000639:trends*; D003141:Communicable Diseases; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice