title: Type 2 diabetes and glycemic response to grapes or grape products.
abstract: Type 2 diabetes affects approximately 7% of the population in the United States and is characterized by decreased disposal of glucose in peripheral tissues due to insulin resistance and overproduction of glucose by the liver, defects in pancreatic beta-cell function, and decreased beta-cell mass. Obesity, decreased physical exercise, and consumption of foods with a high glycemic index (GI) and load are major predisposing factors in the development of type 2 diabetes. The GI is used to evaluate the rise in blood glucose levels in response to food. The GI provides an indication of the quality of carbohydrate in a food. The glycemic load (GL) is used to provide information about the quantity of carbohydrates in a food and the insulin demand. Individuals with diabetes are advised to maintain a diet of low-GL foods, because low-GL diets improve diabetes symptoms. Grapes have a mean GI and GL in the low range. Little research has been performed with grapes and/or grape products to determine the glycemic response either alone or with a meal. Grapes and other fruits contain numerous polyphenols, including the stilbene resveratrol, the flavanol quercetin, catechins, and anthocyanins that have shown potential for reducing hyperglycemia, improving beta-cell function, and protecting against beta-cell loss. Therefore, with a low mean GI and GL, grapes or grape products may provide health benefits to type 2 diabetics.
authors.affiliation: USDA, Agricultural Research Service, Western Human Nutrition Research Center, University of California, Davis, CA 95616, USA. susan.zunino@ars.usda.gov
authors.forename: Susanj
authors.initials: S
authors.lastname: Zunino
mesh_terms: D001786:Blood Glucose / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism / Q000628:therapy*; D004040:Dietary Carbohydrates / Q000378:metabolism*; D005419:Flavonoids / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D005638:Fruit / Q000737:chemistry; D038321:Glycemic Index; D006801:Humans; D010636:Phenols / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D008517:Phytotherapy; D028321:Plant Preparations / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use*; D059808:Polyphenols; D014481:United States; D027843:Vitis / Q000737:chemistry
chemical_list: D001786:Blood Glucose; D004040:Dietary Carbohydrates; D005419:Flavonoids; D010636:Phenols; D028321:Plant Preparations; D059808:Polyphenols