title: Accessible methods for the dynamic time-scale decomposition of biochemical systems.
abstract: BACKGROUND
  The growing complexity of biochemical models asks for means to rationally dissect the networks into meaningful and rather independent subnetworks. Such foregoing should ensure an understanding of the system without any heuristics employed. Important for the success of such an approach is its accessibility and the clarity of the presentation of the results.
  
  
  RESULTS
  In order to achieve this goal, we developed a method which is a modification of the classical approach of time-scale separation. This modified method as well as the more classical approach have been implemented for time-dependent application within the widely used software COPASI. The implementation includes different possibilities for the representation of the results including 3D-visualization.
  
  
  BACKGROUND
  The methods are included in COPASI which is free for academic use and available at www.copasi.org.
  
  
  BACKGROUND
  irina.surovtsova@bioquant.uni-heidelberg.de
  
  
  BACKGROUND
  Supplementary data are available at Bioinformatics online.
authors.affiliation: Department of Modeling of Biological Processes, University of Heidelberg, Im Neuenheimer Feld 267, 69120 Heidelberg, Germany. irina.surovtsova@bioquant.uni-heidelberg.de
authors.forename: Irina
authors.initials: I
authors.lastname: Surovtsova
authors.forename: Natalia
authors.initials: N
authors.lastname: Simus
authors.forename: Thomas
authors.initials: T
authors.lastname: Lorenz
authors.forename: Artjom
authors.initials: A
authors.lastname: König
authors.forename: Sven
authors.initials: S
authors.lastname: Sahle
authors.forename: Ursula
authors.initials: U
authors.lastname: Kummer
mesh_terms: D000465:Algorithms; D019295:Computational Biology / Q000379:methods*; D007700:Kinetics; D008954:Models, Biological; D012984:Software