[Immune modulation and antioxidant effects of wheat peptide on immunosuppressed mice].
We studied immune modulation and antioxidant effects of wheat peptides on immunosuppressed mice. Mice were administrated with wheat peptides orally for 10 days and treated with cyclophosphamide at the 8th day. The indexes including serum hemolysin, plaque forming cells, spleen cells proliferation, liver antioxidant enzymes activties, malondialdehyde (MDA), scavenging serum 2,2-Diphenyl-1-picrylhydrazyl and *OH and macrophage phagocytic ability in vitro were measured to assess the immune functions and antioxidation abilities. In vivo study shows that cyclophosphamide significantly decreases serum hemolysin (HC50) and phagocytic function of macrophages. Simultaneously, liver superoxide dismutase, catalase activity and total oxidation capacity were decreased and malondialdehyde was increased. Wheat peptides could recover HC50 and spleen cell proliferation when orally administrated. Furthermore, they could also enhance serum 2,2-Diphenyl-1-picrylhydrazyl and *OH scavenging. In conclusion, wheat peptides can help body resist the stress related disorders in immune and antioxidant system.
Dai
Hui
H
State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
Le
Guowei
G
Sun
Jin
J
Han
Fang
F
Shi
Yonghui
Y
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D016867:Immunocompromised Host / Q000187:drug effects* / Q000276:immunology; D008297:Male; D051379:Mice; D018384:Oxidative Stress / Q000187:drug effects; D010455:Peptides / Q000276:immunology / Q000494:pharmacology*; D011897:Random Allocation; D014908:Triticum / Q000737:chemistry / Q000276:immunology*
D000276:Adjuvants, Immunologic; D000975:Antioxidants; D010455:Peptides