Recent advances in the genetics of obsessive-compulsive disorder.
This article reviews recent developments in understanding the genetic etiology of obsessive-compulsive disorder (OCD). Family studies provide further support for the familial aggregation of OCD. Genome-wide linkage studies indicate that specific chromosomal regions are linked to OCD. Moreover, results from recent molecular genetic studies suggest that several candidate genes are associated with OCD. However, specific genes causing OCD have not been conclusively identified, and the molecular pathogenesis of the disorder has not been elucidated. The search for genes is complicated by the clinical and etiologic heterogeneity of OCD, as well as the possibility of gene-gene and gene-environment interactions. Despite this complexity, further refinement of the phenotype and developments in molecular and statistical genetics hold promise for further deepening our genetic understanding of OCD in the future.
Samuels
Jack F
JF
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, 1629 Thames Street, Suite 401, Baltimore, MD 21231, USA. jacks@jhmi.edu
D027322:Amino Acid Transport System X-AG / Q000235:genetics; D000818:Animals; D004777:Environment; D005190:Family / Q000523:psychology; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008016:Life Change Events; D051379:Mice; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics; D018433:Twin Studies as Topic / Q000706:statistics & numerical data
D027322:Amino Acid Transport System X-AG; D050486:Serotonin Plasma Membrane Transport Proteins