Avermectin intoxication with coma, myoclonus, and polyneuropathy.
BACKGROUND
Avermectin has been used in the control of parasites and insects. Severe poisoning symptoms in humans include altered mental status, hypotension, and respiratory failure.


METHODS
We describe a case of acute avermectin intoxication at a very high dose (414.2 mg/kg) who presented with coma, myoclonus, and polyneuropathy after oral ingestion.


CONCLUSIONS
The symptoms are supposed to be associated directly with the avermectin poisoning and possibly with the toxicity of solvents or other additives.


CONCLUSIONS
To the best of our knowledge, this is the first case with avermectin poisoning associated with myoclonus and polyneuropathy in the literature.
Sung
Yueh-Feng
YF
Department of Neurology, Tri-Service General Hospital, Taipei, Taiwan, Republic of China. sungyf@ndmctsgh.edu.tw
Huang
Chuang-Ti
CT
Fan
Cheng-Kuo
CK
Lin
Chih-Hung
CH
Lin
Shiou-Ping
SP
D000203:Activities of Daily Living; D000368:Aged; D003128:Coma / Q000139:chemically induced* / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D007306:Insecticides / Q000506:poisoning*; D007559:Ivermectin / Q000031:analogs & derivatives* / Q000506:poisoning; D008297:Male; D009207:Myoclonus / Q000139:chemically induced* / Q000503:physiopathology / Q000628:therapy; D017933:Peripheral Nervous System / Q000187:drug effects / Q000503:physiopathology; D011041:Poisoning / Q000150:complications* / Q000503:physiopathology / Q000628:therapy; D011115:Polyneuropathies / Q000139:chemically induced* / Q000503:physiopathology / Q000628:therapy; D013406:Suicide, Attempted
D007306:Insecticides; D007559:Ivermectin; C019264:avermectin