title: eNOS G894T polymorphism and abdominal aortic aneurysms.
abstract: BACKGROUND
  The genetic risk factors that contribute to the risk of developing abdominal aortic aneurysm (AAA) are poorly understood. We assessed the association of endothelial nitric oxide synthase (eNOS) gene polymorphism with AAA.
  
  
  METHODS
  eNOS gene polymorphism of 61 patients with AAA and 62 control participants were analyzed by polymerase chain reaction (PCR)-restriction technique.
  
  
  RESULTS
  eNOS G894 homozygote T/T genotype polymorphism and 894T allele frequency in patients with AAA were significantly higher than those of the control participants (P = .01, P = .03). Among patients with AAA, the eNOS G894 T/T polymorphism and 894T allele frequency were associated with larger AAAs.
  
  
  CONCLUSIONS
  The current study, in a small group of participants, showed a relationship between eNOS G894T polymorphism and AAA.
authors.affiliation: Department of Cardiovascular Surgery, Urfa State Hospital, Urfa, Turkey.
authors.forename: Fahri Hayri
authors.initials: FH
authors.lastname: Atli
authors.forename: Sinasi
authors.initials: S
authors.lastname: Manduz
authors.forename: Nurkay
authors.initials: N
authors.lastname: Katrancioglu
authors.forename: Unal
authors.initials: U
authors.lastname: Ozum
authors.forename: Olcay Murat
authors.initials: OM
authors.lastname: Disli
authors.forename: Erhan
authors.initials: E
authors.lastname: Atahan
authors.forename: Ozturk
authors.initials: O
authors.lastname: Ozdemir
authors.forename: Kasim
authors.initials: K
authors.lastname: Dogan
authors.forename: Ocal
authors.initials: O
authors.lastname: Berkan
mesh_terms: D000368:Aged; D017544:Aortic Aneurysm, Abdominal / Q000235:genetics* / Q000503:physiopathology; D004730:Endothelium, Vascular / Q000503:physiopathology; D005260:Female; D005787:Gene Frequency; D006801:Humans; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000502:physiology; D052250:Nitric Oxide Synthase Type III / Q000235:genetics*; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length
chemical_list: D009569:Nitric Oxide; D052250:Nitric Oxide Synthase Type III