title: Traffic jams during vesicle cycling lead to synaptic depression.
abstract: During prolonged stimulation, fusion of thousands of synaptic vesicles poses a challenge for the temporal and spatial coordination of exocytosis and endocytosis. In this issue of Neuron, Hosoi and colleagues reveal that [Ca2+](i)-microdomains trigger compensatory endocytosis. Block of endocytosis enhances short-term depression by delaying vesicle recruitment to docking sites on active zones.
authors.affiliation: The Vollum Institute, Oregon Health and Science University, Portland, OR 97239, USA.
authors.forename: Jun Hee
authors.initials: JH
authors.lastname: Kim
authors.forename: Henrique
authors.initials: H
authors.lastname: von Gersdorff
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D002118:Calcium / Q000378:metabolism; D015220:Calcium Channels / Q000502:physiology*; D004705:Endocytosis / Q000502:physiology*; D005089:Exocytosis / Q000502:physiology*; D009433:Neural Inhibition / Q000502:physiology*; D017729:Presynaptic Terminals / Q000378:metabolism; D009435:Synaptic Transmission / Q000502:physiology; D013572:Synaptic Vesicles / Q000378:metabolism*
chemical_list: D015220:Calcium Channels; D002118:Calcium