title: Running the gauntlet: an overview of the modalities of travel employed by the putative morphogen Nodal.
abstract: A fundamental challenge in biology is to explain how progenitor cells in developing tissues acquire distinct fates according to their position. In vertebrates, the positional information that specifies the germ layers and the primary body axes is mediated by Nodal. Nodal meets the criteria of a morphogen since it can diffuse through tissues and signal far away from its source to directly specify multiple cell fates in a dosage-dependent manner. To consider the relationship between trafficking and graded Nodal signaling, this review summarizes recent findings how the spreading of Nodal activity is regulated by factors that promote long range signaling during left-right axis formation, and by structural features that affect Nodal protein stability and endosomal sorting.
authors.affiliation: Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH 1015 Lausanne, Switzerland. Daniel.Constam@epfl.ch
authors.forename: Daniel B
authors.initials: DB
authors.lastname: Constam
mesh_terms: D000818:Animals; D019521:Body Patterning / Q000235:genetics; D004625:Embryo, Nonmammalian / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D055458:Left-Right Determination Factors; D055457:Nodal Protein / Q000235:genetics* / Q000378:metabolism*; D055456:Nodal Signaling Ligands; D021381:Protein Transport; D015398:Signal Transduction / Q000235:genetics
chemical_list: D055458:Left-Right Determination Factors; D055457:Nodal Protein; D055456:Nodal Signaling Ligands