title: Effect of domperidone on the QTc interval in premature infants.
abstract: OBJECTIVE
  To evaluate the effect of domperidone use on corrected QT interval in premature infants.
  
  
  METHODS
  A prospective study of premature infants receiving domperidone was included in this study. A baseline electrocardiogram was obtained just before and 3, 7 and 14 days after initiation of domperidone. Corrected QT was considered prolonged if it exceeded the upper limit for age.
  
  
  RESULTS
  A total of 40 premature infants were enrolled in this study. The mean birth weight of 1109+/-332 g, mean gestational age of 28.8+/-2.4 years and mean age at the onset of domperidone were 32.8+/-2 days. No difference in corrected QT interval was observed between just before and 3, 7 and 14 days after the start of the treatment. Two infants had corrected QT interval prolongation without any clinical side effect that resolved spontaneously.
  
  
  CONCLUSIONS
  Our experience suggests that domperidone administered cautiously in modest doses does not result in arrhythmias or conduction defects in premature infants statistically. Additional data are needed to give optimal advice regarding the safety of domperidone treatment in premature infants.
authors.affiliation: Department of Neonatology, Kocaeli University Faculty of Medicine, Kocaeli, Turkey. aylagunlemez@yahoo.com
authors.forename: A
authors.initials: A
authors.lastname: Günlemez
authors.forename: A
authors.initials: A
authors.lastname: Babaoğlu
authors.forename: A E
authors.initials: AE
authors.lastname: Arisoy
authors.forename: G
authors.initials: G
authors.lastname: Türker
authors.forename: A S
authors.initials: AS
authors.lastname: Gökalp
mesh_terms: D004294:Domperidone / Q000494:pharmacology*; D018492:Dopamine Antagonists / Q000494:pharmacology*; D004562:Electrocardiography / Q000187:drug effects*; D005260:Female; D005764:Gastroesophageal Reflux / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D019370:Observation; D011446:Prospective Studies
chemical_list: D018492:Dopamine Antagonists; D004294:Domperidone