title: Novel pleuromutilin derivatives with excellent antibacterial activity against Staphylococcus aureus.
abstract: Ten novel pleuromutilin derivatives with thioether moiety and heterocyclic carboxamide or chloroformate group in the side chain were synthesized and confirmed by (1)H NMR, IR and HRMS. The results of the antibacterial activity showed that the title compounds had excellent antibacterial activity against Staphylococcus aureus, among which the MIC of 5f reached 0.03125 microg/mL.
authors.affiliation: College of Chemistry, Sichuan University, Chengdu, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Xu
authors.forename: Yuan-Yuan
authors.initials: YY
authors.lastname: Zhang
authors.forename: Yong-Xue
authors.initials: YX
authors.lastname: Sun
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Liu
authors.forename: Bing
authors.initials: B
authors.lastname: Yang
authors.forename: Yu-Zhong
authors.initials: YZ
authors.lastname: Wang
authors.forename: Yu-Liang
authors.initials: YL
authors.lastname: Wang
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D011083:Polycyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D011720:Pyrazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects*; D000097567:Pleuromutilins
chemical_list: D000900:Anti-Bacterial Agents; D004224:Diterpenes; D011083:Polycyclic Compounds; D011720:Pyrazoles; D000097567:Pleuromutilins; C544204:mutilin 14-O-(1-(1-methyl-4-nitro-3-propyl-1H-pyrazolecarboxamide)-2-methylpropane-2-yl)thioacetate