title: Palladium-catalyzed sequential cyanation/n-addition/N-arylation in one-pot: efficient synthesis of luotonin A and its derivatives.
abstract: With the catalysis of palladium, a number of 2-bromo-N-(2-iodobenzyl)benzamides underwent sequential cyanation/N-addition/N-arylation leading to the efficient construction of isoindolo[1,2-b]quinazolin-10(12H)-ones in a two-stage, one-pot manner. This method also allowed the convenient synthesis of luotonin A and its derivatives.
authors.affiliation: Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, PR China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Ju
authors.forename: Feng
authors.initials: F
authors.lastname: Liu
authors.forename: Chaozhong
authors.initials: C
authors.lastname: Li
mesh_terms: D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry; D011809:Quinones / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D011758:Pyrroles; D011809:Quinones; C480761:luotonin A; D010165:Palladium