N-terminal pro-brain natriuretic peptide in cases with metabolic syndrome and its relationship with components of metabolic syndrome and left ventricular mass index.
OBJECTIVE
In this study we investigated N-terminal pro-brain natriuretic peptide (Nt-proBNP) levels in patients with metabolic syndrome (MetS) and its relationship between MetS components.


METHODS
Thirty nine recently diagnosed MetS cases and 59 control cases were included in the present study. Left ventricular mass index (LVMI) was calculated and Nt-proBNP was determined.


RESULTS
Both groups were similar in terms of age and sex. Body mass index were significantly higher in MetS than non-MetS. LVMI measurements were not different between MetS and control groups (p=0.168). Nt-proBNP levels were similar in both groups (p=0.954). There was a significant correlation between Nt-proBNP and LVMI, age, serum LDL- and HDL-cholesterol levels. Nt-proBNP was independently related with age (beta=0.357, p=0.015) and LDL-cholesterol (beta=-0.255, p=0.049) in the multivariate analysis.


CONCLUSIONS
Nt-proBNP levels don't have a significant increase in MetS. But there was a significant relationship between Nt-proBNP levels and age and LDL-cholesterol.
Sezen
Yusuf
Y
Harran University, Faculty of Medicine, Department of Cardiology, Sanliurfa, Turkey. yusufsezen@yahoo.com
Baş
Memduh
M
Demirbag
Recep
R
Yildiz
Ali
A
Celik
Hakim
H
Aksoy
Sahin
S
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D001794:Blood Pressure / Q000502:physiology; D015992:Body Mass Index; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D006352:Heart Ventricles / Q000033:anatomy & histology*; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000473:pathology; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D018487:Ventricular Dysfunction, Left / Q000378:metabolism; D055815:Young Adult
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain