title: Long-term survival following a single treatment of kidney tumors with multiwalled carbon nanotubes and near-infrared radiation.
abstract: Multiwalled carbon nanotubes (MWCNTs) exhibit physical properties that render them ideal candidates for application as noninvasive mediators of photothermal cancer ablation. Here, we demonstrate that use of MWCNTs to generate heat in response to near-infrared radiation (NIR) results in thermal destruction of kidney cancer in vitro and in vivo. We document the thermal effects of the therapy through magnetic resonance temperature-mapping and heat shock protein-reactive immunohistochemistry. Our results demonstrate that use of MWCNTs enables ablation of tumors with low laser powers (3 W/cm(2)) and very short treatment times (a single 30-sec treatment) with minimal local toxicity and no evident systemic toxicity. These treatment parameters resulted in complete ablation of tumors and a >3.5-month durable remission in 80% of mice treated with 100 microg of MWCNT. Use of MWCNTs with NIR may be effective in anticancer therapy.
authors.affiliation: Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA.
authors.forename: Andrew
authors.initials: A
authors.lastname: Burke
authors.forename: Xuanfeng
authors.initials: X
authors.lastname: Ding
authors.forename: Ravi
authors.initials: R
authors.lastname: Singh
authors.forename: Robert A
authors.initials: RA
authors.lastname: Kraft
authors.forename: Nicole
authors.initials: N
authors.lastname: Levi-Polyachenko
authors.forename: Marissa Nichole
authors.initials: MN
authors.lastname: Rylander
authors.forename: Chris
authors.initials: C
authors.lastname: Szot
authors.forename: Cara
authors.initials: C
authors.lastname: Buchanan
authors.forename: Jon
authors.initials: J
authors.lastname: Whitney
authors.forename: Jessica
authors.initials: J
authors.lastname: Fisher
authors.forename: Heather C
authors.initials: HC
authors.lastname: Hatcher
authors.forename: Ralph
authors.initials: R
authors.lastname: D'Agostino
authors.forename: Nancy D
authors.initials: ND
authors.lastname: Kock
authors.forename: P M
authors.initials: PM
authors.lastname: Ajayan
authors.forename: David L
authors.initials: DL
authors.lastname: Carroll
authors.forename: Steven
authors.initials: S
authors.lastname: Akman
authors.forename: Frank M
authors.initials: FM
authors.lastname: Torti
authors.forename: Suzy V
authors.initials: SV
authors.lastname: Torti
mesh_terms: D000818:Animals; D017115:Catheter Ablation; D045744:Cell Line, Tumor; D006360:Heat-Shock Proteins / Q000096:biosynthesis; D006979:Hyperthermia, Induced / Q000379:methods*; D007259:Infrared Rays / Q000627:therapeutic use; D007680:Kidney Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D051379:Mice; D050997:Nanomedicine / Q000379:methods*; D037742:Nanotubes, Carbon / Q000737:chemistry*; D010789:Phototherapy / Q000379:methods*; D013696:Temperature
chemical_list: D006360:Heat-Shock Proteins; D037742:Nanotubes, Carbon