title: Regulatory roles of natural antisense transcripts.
abstract: Mammalian genomes encode numerous natural antisense transcripts, but the function of these transcripts is not well understood. Functional validation studies indicate that antisense transcripts are not a uniform group of regulatory RNAs but instead belong to multiple categories with some common features. Recent evidence indicates that antisense transcripts are frequently functional and use diverse transcriptional and post-transcriptional gene regulatory mechanisms to carry out a wide variety of biological roles.
authors.affiliation: Molecular and Integrative Neurosciences Department, The Scripps Research Institute, Jupiter, Florida 33458, USA.
authors.forename: Mohammad Ali
authors.initials: MA
authors.lastname: Faghihi
authors.forename: Claes
authors.initials: C
authors.lastname: Wahlestedt
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D016372:RNA, Antisense / Q000502:physiology*
chemical_list: D016372:RNA, Antisense