title: Efficacy of silver diamine fluoride for Arresting Caries Treatment.
abstract: Arresting Caries Treatment (ACT) has been proposed to manage untreated dental caries in children. This prospective randomized clinical trial investigated the caries-arresting effectiveness of a single spot application of: (1) 38% silver diamine fluoride (SDF) with tannic acid as a reducing agent; (2) 38% SDF alone; (3) 12% SDF alone; and (4) no SDF application in primary teeth of 976 Nepalese schoolchildren. The a priori null hypothesis was that the different treatments have no effect in arresting active cavitated caries. Only the single application of 38% SDF with or without tannic acid was effective in arresting caries after 6 months (4.5 and 4.2 mean number of arrested surfaces; p < 0.001), after 1 year (4.1 and 3.4; p < 0.001), and after 2 years (2.2 and 2.1; p < 0.01). Tannic acid conferred no additional benefit. ACT with 38% SDF provides an alternative when restorative treatment for primary teeth is not an option.
authors.affiliation: Department of Global Oral Health, Radboud University Nijmegen Medical Centre, College of Dental Sciences, PO Box 9101, 6500 HB Nijmegen, The Netherlands.
authors.forename: R
authors.initials: R
authors.lastname: Yee
authors.forename: C
authors.initials: C
authors.lastname: Holmgren
authors.forename: J
authors.initials: J
authors.lastname: Mulder
authors.forename: D
authors.initials: D
authors.lastname: Lama
authors.forename: D
authors.initials: D
authors.lastname: Walker
authors.forename: W
authors.initials: W
authors.lastname: van Palenstein Helderman
mesh_terms: D002327:Cariostatic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004245:DMF Index; D003731:Dental Caries / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D005260:Female; D005460:Fluorides, Topical / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D011446:Prospective Studies; D000644:Quaternary Ammonium Compounds / Q000008:administration & dosage / Q000627:therapeutic use*; D018030:Silver Compounds; D013634:Tannins / Q000627:therapeutic use; D014094:Tooth, Deciduous
chemical_list: D002327:Cariostatic Agents; D004338:Drug Combinations; D005460:Fluorides, Topical; D000644:Quaternary Ammonium Compounds; D018030:Silver Compounds; D013634:Tannins; C024633:silver diamine fluoride