title: Maternal and fetal variants in the TGF-beta3 gene and risk of pregnancy-induced hypertension in a predominantly Latino population.
abstract: OBJECTIVE
  We sought to determine whether polymorphisms in the transforming growth factor (TGF)-beta3 gene are associated with risk of pregnancy-induced hypertension (PIH) in case-control mother-baby dyads.
  
  
  METHODS
  Patients (n = 136) and control subjects (n = 169) were recruited from our hospital. We genotyped 4 TGF-beta3 polymorphisms and examined association with PIH using logistic regression, adjusting for parity, maternal age, gestational age at delivery, fetal (or maternal) genotypes for the polymorphism in question, and the 3 other polymorphisms within the TGF-beta3 gene.
  
  
  RESULTS
  Only 1 of the TGF-beta3 polymorphisms (rs11466414) was associated with PIH. Mothers who carried a baby with a minor allele were at decreased risk (odds ratio(multi-locus adj), 0.32; 95% confidence interval, 0.14-0.77). Maternal TGF-beta3 variants had no effect on risk of PIH.
  
  
  CONCLUSIONS
  A fetal TGF-beta3 polymorphism (rs11466414) is associated with PIH in a predominantly Hispanic population.
authors.affiliation: Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
authors.forename: Melissa L
authors.initials: ML
authors.lastname: Wilson
authors.forename: Daniel H
authors.initials: DH
authors.lastname: Desmond
authors.forename: T Murphy
authors.initials: TM
authors.lastname: Goodwin
authors.forename: David A
authors.initials: DA
authors.lastname: Miller
authors.forename: Sue Ann
authors.initials: SA
authors.lastname: Ingles
mesh_terms: D015897:Comorbidity; D005260:Female; D005333:Fetus / Q000502:physiology*; D005838:Genotype; D005865:Gestational Age; D006630:Hispanic or Latino / Q000235:genetics*; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000208:ethnology* / Q000235:genetics*; D016015:Logistic Models; D010298:Parity; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011247:Pregnancy; D012189:Retrospective Studies; D053782:Transforming Growth Factor beta3 / Q000235:genetics*
chemical_list: D053782:Transforming Growth Factor beta3