title: Long-term linezolid treatment in a young child with extensively drug-resistant tuberculosis.
abstract: Treatment of extensively drug-resistant tuberculosis (XDR-TB) is a challenge. We describe a young child with pulmonary XDR-TB who did not respond to an aggressive multidrug-resistant TB treatment regimen, but was cured with linezolid in combination with other reserve antituberculous drugs. No serious adverse events were observed during 19 months of treatment for XDR-TB.
authors.affiliation: Department of Paediatrics and Child Health, Stellenbosch University and Tygerberg Children's Hospital, Cape Town, South Africa. hss@sum.ac.za
authors.forename: H Simon
authors.initials: HS
authors.lastname: Schaaf
authors.forename: Marianne
authors.initials: M
authors.lastname: Willemse
authors.forename: Peter R
authors.initials: PR
authors.lastname: Donald
mesh_terms: D000081:Acetamides / Q000008:administration & dosage* / Q000009:adverse effects; D000995:Antitubercular Agents / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D024901:Drug Resistance, Multiple, Bacterial; D054908:Extensively Drug-Resistant Tuberculosis / Q000188:drug therapy* / Q000382:microbiology; D005260:Female; D006801:Humans; D007223:Infant; D000069349:Linezolid; D023303:Oxazolidinones / Q000008:administration & dosage* / Q000009:adverse effects; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D000081:Acetamides; D000995:Antitubercular Agents; D023303:Oxazolidinones; D000069349:Linezolid