Caspase substrates and neurodegenerative diseases.
Apoptosis is induced by the cleavage of a subset of cellular proteins by proteases of the caspase family. Numerous (hundreds) caspase substrates have been described but only for a few of them is the function of their cleavage by caspases well understood. In this review, apoptosis and caspases will first be introduced. The main focus will then be directed to the caspase substrates, the actual "workers" doing the job of mediating and regulating the apoptotic process. The caspase substrates whose functions upon cleavage have been carefully investigated and those that are potentially involved in neurodegenerative diseases will be discussed in detail.
Bulat
Natasa
N
Department of Physiology, Lausanne University, 1005 Lausanne, Switzerland.
Widmann
Christian
C
D016564:Amyloid beta-Protein Precursor / Q000378:metabolism; D000818:Animals; D020169:Caspases / Q000378:metabolism*; D006801:Humans; D000071058:Huntingtin Protein; D009419:Nerve Tissue Proteins / Q000378:metabolism; D019636:Neurodegenerative Diseases / Q000378:metabolism*; D009687:Nuclear Proteins / Q000378:metabolism; D053763:Presenilins / Q000378:metabolism; D016875:tau Proteins / Q000378:metabolism
D016564:Amyloid beta-Protein Precursor; C086055:HTT protein, human; D000071058:Huntingtin Protein; D009419:Nerve Tissue Proteins; D009687:Nuclear Proteins; D053763:Presenilins; D016875:tau Proteins; D020169:Caspases