Granular cell tumor (Abrikossoff tumor) of the thyroid gland.
Only 4 cases of granular cell tumor of the thyroid have been previously reported in the English literature. We report herein the fifth case of this uncommon neoplasm and the first one affecting a male patient. The tumor was well circumscribed and located to the left thyroid lobe, near the isthmus. Histologically, the tumor was composed of large, rounded, granular eosinophilic cells that were immunohistochemically positive for S-100, calretinin, and PGP9.5 and negative for cytokeratin AE1-3, TTF-1, and thyroglobulin.
Espinosa-de-Los-Monteros-Franco
Vladimir A
VA
Department of Pathology, The American British Cowdray Medical Center, Mexico D.F. 01120, Mexico.
Martínez-Madrigal
Fernando
F
Ortiz-Hidalgo
Carlos
C
D064032:Calbindin 2; D016586:Granular Cell Tumor / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008297:Male; D064030:S100 Calcium Binding Protein G / Q000378:metabolism; D009418:S100 Proteins / Q000378:metabolism; D013964:Thyroid Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D043222:Ubiquitin Thiolesterase / Q000378:metabolism; D055815:Young Adult
C576764:CALB2 protein, human; D064032:Calbindin 2; D064030:S100 Calcium Binding Protein G; D009418:S100 Proteins; C482860:UCHL1 protein, human; D043222:Ubiquitin Thiolesterase