Finding Leishmania: a deadly game of hide-and-seek.
Leishmaniasis is a chronic infection in which intracellular parasites avoid destruction by the immune system. Using intravital imaging, Filipe-Santos et al. (2009) demonstrate that some parasitized dendritic cells receive much less attention than others during their choreographed dance with T cells, suggesting that these "wallflowers" could allow for parasite survival.
Scott
Phillip
P
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. pscott@vet.upenn.edu
D000818:Animals; D003713:Dendritic Cells / Q000469:parasitology*; D007891:Leishmania / Q000276:immunology* / Q000472:pathogenicity*; D007896:Leishmaniasis / Q000276:immunology* / Q000469:parasitology*; D008954:Models, Biological; D013194:Staining and Labeling / Q000379:methods; D013601:T-Lymphocytes / Q000276:immunology*