Insights on nuclease mechanism: the role of proximal ammonium group on phosphate esters cleavage.
The role of remotely located ammonium groups in the active site of many phosphate-cleaving enzymes is investigated by using model systems thus providing mechanistic hints to a still unsolved problem.
Bonomi
Renato
R
Dipartimento di Scienze Chimiche and CNR-ITM, Universita di Padova, via Marzolo 1, I-35131 Padova, Italy.
Saielli
Giacomo
G
Tonellato
Umberto
U
Scrimin
Paolo
P
Mancin
Fabrizio
F
D020134:Catalytic Domain; D004720:Endonucleases / Q000737:chemistry / Q000378:metabolism*; D008958:Models, Molecular; D010755:Organophosphates / Q000378:metabolism*; D000644:Quaternary Ammonium Compounds / Q000737:chemistry / Q000378:metabolism*
D010755:Organophosphates; D000644:Quaternary Ammonium Compounds; D004720:Endonucleases