Emerging roles of peroxisome proliferator-activated receptor-beta/delta in inflammation.
Peroxisome proliferator-activated receptor (PPAR)-beta/delta is a member of the PPAR nuclear hormone receptor family. The PPARs are a family of 3 ligand-activated transcription factors: PPARalpha (NR1C1), PPARbeta/delta (NR1C2), and PPARgamma (NR1C3). All the PPARs play important roles in the regulation of metabolic pathways, including those of lipid of biosynthesis and glucose metabolism, as well as in a variety of cell differentiation, proliferation, and apoptosis pathways. Recently, there has been a great deal of interest in the involvement of PPARs in the inflammatory processes. In particular, PPARalpha and PPARgamma inhibit the activation of inflammatory gene expression and can negatively interfere with pro-inflammatory transcription factor signalling pathways in vascular and inflammatory cells. In contrast, the roles of PPARbeta/delta regulating inflammation and immunity are only just emerging. This review will focus on these emerging roles of PPARbeta/delta in regulating inflammatory processes.
Bishop-Bailey
David
D
Translational Medicine and Therapeutics, William Harvey Research Institute, Barts and The London, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK. d.bishop-bailey@qmul.ac.uk
Bystrom
Jonas
J
D000818:Animals; D006801:Humans; D007249:Inflammation / Q000235:genetics / Q000378:metabolism; D018836:Inflammation Mediators / Q000378:metabolism / Q000502:physiology*; D008024:Ligands; D047494:PPAR delta / Q000378:metabolism / Q000502:physiology*; D048068:PPAR-beta / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
D018836:Inflammation Mediators; D008024:Ligands; D047494:PPAR delta; D048068:PPAR-beta