title: [Study on preparation and release mechanism of effervescent osmotic pump tablet of compound Danshen].
abstract: OBJECTIVE
  To prepare effervescent osmotic pump tablet (EOPTs) according to the rhythm of coronary heart disease based on efficacy material and the mechanism of compound Danshen and to study the mechanism of drug released of that tablets.
  
  
  METHODS
  Since compound Danshen consist of compounds with polyphenolic groups or carboxyl groups, such as phenolic acids, flavonoids, and triterpenoids that they were acidic. EOPTs were prepared from tablet cores which containing NaHCO3 as effervescent, NaCL and manitol as osmotic agents, HPMC as retarding agents coating with CA membrane. And study the mechanism of drug released according to the change of tablet osmotic pressure.
  
  
  RESULTS
  The results of in vitro experiments showed that no difference was observed among the profiles of Danshensu, protocatechuic aldehyde, ginsenoside Rg1, Rb1, notoginsenoside R1 release EOPTs. The drug was completely released from the device with a zero-order release rate over 12 h.
  
  
  CONCLUSIONS
  EOPTs are Successfully obtained EOPT which the drug is released from the device over 12 h and the release mechanism of EOPTs is explained.
authors.affiliation: Hairong Yangtze River Pharmaceutical Group of Sichuan Pharmaceutical Co. Ltd., Dujiangyan 611830, China. anliking@163.com
authors.forename: Li'an
authors.initials: L
authors.lastname: Xue
authors.forename: Yuanbo
authors.initials: Y
authors.lastname: Li
authors.forename: Dandan
authors.initials: D
authors.lastname: Guo
authors.forename: Jianhua
authors.initials: J
authors.lastname: Yin
authors.forename: Yanchun
authors.initials: Y
authors.lastname: Liu
authors.forename: Shixiang
authors.initials: S
authors.lastname: Hou
mesh_terms: D003327:Coronary Disease / Q000503:physiopathology; D004339:Drug Compounding; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage* / Q000378:metabolism*; D007260:Infusion Pumps; D009995:Osmosis; D027561:Salvia miltiorrhiza / Q000378:metabolism*; D013607:Tablets; D013997:Time Factors
chemical_list: D004365:Drugs, Chinese Herbal; D013607:Tablets