title: [Study on vitro release and transdermal behaviors of Yulian cataplasm].
abstract: OBJECTIVE
  To investigate the regularity of Yulian Cataplasm in vitro release and transdermal behaviors.
  
  
  METHODS
  Improved Franz diffusion devices was used with four index ingredients as evodiamine, rutaecarpine, palmatine and berberine that were determined by HPLC in one mobile phase.
  
  
  RESULTS
  The release rates of evodiamine, rutaecarpine, palmatine and berberine were 0.0239, 0.0156, 0.0725, 0.8191 mg x cm(-2) x h(-1/2), respectivley. The transdermal rates of evodiamine, rutaecarpine, palmatine and berberine were 1.256, 1.0302, 2.8029, 20.919 microg x cm(-2) x h(-1), respectively.
  
  
  CONCLUSIONS
  The releasing process of all index is in accordance with Higuchi equation and the transdermal proccess is in accordance with zero-level equation.
authors.affiliation: Institute of Chinese Materia Medica China Academy of Chinese Medical Science, Beijing 100700, China.
authors.forename: Maobo
authors.initials: M
authors.lastname: Du
authors.forename: Shuzhi
authors.initials: S
authors.lastname: Liu
authors.forename: Manling
authors.initials: M
authors.lastname: Li
authors.forename: Rixian
authors.initials: R
authors.lastname: Jin
authors.forename: Chen
authors.initials: C
authors.lastname: Kang
authors.forename: Junhong
authors.initials: J
authors.lastname: Li
mesh_terms: D000818:Animals; D001599:Berberine / Q000008:administration & dosage / Q000493:pharmacokinetics; D001600:Berberine Alkaloids / Q000008:administration & dosage / Q000493:pharmacokinetics; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000493:pharmacokinetics*; D026121:Indole Alkaloids / Q000008:administration & dosage / Q000493:pharmacokinetics; D051379:Mice; D010936:Plant Extracts / Q000008:administration & dosage / Q000493:pharmacokinetics; D011799:Quinazolines / Q000008:administration & dosage / Q000493:pharmacokinetics; D012867:Skin / Q000378:metabolism*; D012869:Skin Absorption; D052999:Quinazolinones
chemical_list: D001599:Berberine; D001600:Berberine Alkaloids; D004365:Drugs, Chinese Herbal; D026121:Indole Alkaloids; D010936:Plant Extracts; D011799:Quinazolines; C028632:rutecarpine; D052999:Quinazolinones; C049639:evodiamine; C005413:palmatine