Synthesis and evaluation of photoreactive tetrazole amino acids.
Six photoreactive tetrazole amino acids were efficiently synthesized either by the de novo Kakehi tetrazole synthesis method or by alkylation of a glycine Schiff base with tetrazole-containing alkyl halides, and four of them showed excellent reactivity toward a simple alkene in the photoinduced 1,3-dipolar cycloaddition reaction in acetonitrile/PBS buffer (1:1) mixture.
Wang
Yizhong
Y
Department of Chemistry, State University of New York at Buffalo, Buffalo, New York 14260-3000, USA.
Lin
Qing
Q
D000478:Alkylation; D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques; D015394:Molecular Structure; D055668:Photochemical Processes; D013777:Tetrazoles / Q000138:chemical synthesis* / Q000737:chemistry
D000596:Amino Acids; D013777:Tetrazoles; C045574:1H-tetrazole