Size control of arsenic trioxide nanocrystals grown in nanowells.
This paper describes a new strategy to generate nanocrystalline drugs through the precipitation of drug molecules in attoliter nanowells. We controlled the size of arsenic trioxide (ATO) nanocrystals by simply changing the concentration of ATO solution in the nanowells; particles with sizes ranging from 55 to 175 nm were formed. This approach only requires the drugs to be soluble in a solvent and thus can be broadly applicable to produce other drugs in nanocrystalline form.
You
Eun-Ah
EA
Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3133, USA.
Ahn
Richard W
RW
Lee
Min Hyung
MH
Raja
Meera R
MR
O'Halloran
Thomas V
TV
Odom
Teri W
TW
D000077237:Arsenic Trioxide; D001152:Arsenicals / Q000737:chemistry*; D003460:Crystallization / Q000379:methods; D053758:Nanoparticles; D010087:Oxides / Q000737:chemistry*; D010316:Particle Size; D004364:Pharmaceutical Preparations / Q000737:chemistry*
D001152:Arsenicals; D010087:Oxides; D004364:Pharmaceutical Preparations; D000077237:Arsenic Trioxide