title: Extensive extranodal metastases of basal-like breast cancer with predominant myoepithelial spindle cell differentiation.
abstract: A differentiation towards myoepithelial cells has been demonstrated in several types of lesions in the breast. These include multifocal myoepitheliomatosis, the rare mixed tumor or pleomorphic adenoma, adenoid cystic carcinoma, adenomyoepithelioma and myoepithelial carcinoma (malignant myoepithelioma). Myoepithelial carcinoma is the only lesion purely composed of myoepithelial cells. All these tumors are benign and/or of low-grade malignancy, with the exception of malignant myoepithelioma. In contrast to the statement of the current World Health Organization (WHO), recent studies have reported that regional and distant metastases may occur in about 50% of pure myoepithelial carcinomas. The presented case of a breast carcinoma with dominant myoepithelial/spindle cell differentiation in a 58-year-old woman is an excellent example to document the highly aggressive biological behavior of this tumor phenotype. Despite an extensive chemotherapy and radiotherapy, the tumor was rapidly progressive, forming a finally exulcerating local tumor relapse and widespread metastases to the myocardium, lungs, liver, kidneys and skin. Similarities in morphology and biological behavior compared to patients with "triple-negative" (hormone receptor and Her2) monophasic sarcomatoid carcinomas and pure spindle cell sarcomas are discussed.
authors.affiliation: Department of Internal Medicine, Kantonsspital Graubünden, 7000 Chur, Switzerland.
authors.forename: Roman
authors.initials: R
authors.lastname: Trepp
authors.forename: Barbara C
authors.initials: BC
authors.lastname: Padberg
authors.forename: Zsuzsanna
authors.initials: Z
authors.lastname: Varga
authors.forename: Richard
authors.initials: R
authors.lastname: Cathomas
authors.forename: Roman
authors.initials: R
authors.lastname: Inauen
authors.forename: Walter H
authors.initials: WH
authors.lastname: Reinhart
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology*; D002277:Carcinoma / Q000378:metabolism / Q000556:secondary*; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000378:metabolism / Q000556:secondary*; D008113:Liver Neoplasms / Q000378:metabolism / Q000556:secondary*; D008175:Lung Neoplasms / Q000378:metabolism / Q000556:secondary*; D008875:Middle Aged; D012878:Skin Neoplasms / Q000378:metabolism / Q000556:secondary*
chemical_list: D014408:Biomarkers, Tumor