(1)H, (13)C and (15)N backbone assignments for the ligand binding domain of the Pseudomonas aeruginosa virulence regulator LasR.
LasR regulates toxin production in Pseudomonas aeruginosa and its inhibition can attenuate the virulence of this opportunistic human pathogen. To aid studies of interactions with inhibitors, we report the NMR backbone assignments for the dimeric LasR ligand-binding domain.
Bottomley
Matthew James
MJ
Istituto di Ricerche di Biologia Molecolare, Pomezia, Roma, Italy. matthew_bottomley@merck.com
Muraglia
Ester
E
Bazzo
Renzo
R
D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000737:chemistry*; D002247:Carbon Isotopes / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008970:Molecular Weight; D009587:Nitrogen Isotopes / Q000737:chemistry; D017434:Protein Structure, Tertiary; D011522:Protons; D011550:Pseudomonas aeruginosa / Q000378:metabolism*; D015534:Trans-Activators / Q000737:chemistry*
D001426:Bacterial Proteins; D002247:Carbon Isotopes; C080365:LasR protein, Pseudomonas aeruginosa; D009587:Nitrogen Isotopes; D011522:Protons; D015534:Trans-Activators