title: Genetic variants at 6p21.33 are associated with susceptibility to follicular lymphoma.
abstract: We conducted genome-wide association studies of non-Hodgkin lymphoma using Illumina HumanHap550 BeadChips to identify subtype-specific associations in follicular, diffuse large B-cell and chronic lymphocytic leukemia/small lymphocytic lymphomas. We found that rs6457327 on 6p21.33 was associated with susceptibility to follicular lymphoma (FL; N = 189 cases, 592 controls) with validation in another 456 FL cases and 2,785 controls (combined allelic P = 4.7 x 10(-11)). The region of strongest association overlapped C6orf15 (STG), located near psoriasis susceptibility region 1 (PSORS1).
authors.affiliation: Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, California, USA. chrisfs@berkeley.edu
authors.forename: Christine F
authors.initials: CF
authors.lastname: Skibola
authors.forename: Paige M
authors.initials: PM
authors.lastname: Bracci
authors.forename: Eran
authors.initials: E
authors.lastname: Halperin
authors.forename: Lucia
authors.initials: L
authors.lastname: Conde
authors.forename: David W
authors.initials: DW
authors.lastname: Craig
authors.forename: Luz
authors.initials: L
authors.lastname: Agana
authors.forename: Kelly
authors.initials: K
authors.lastname: Iyadurai
authors.forename: Nikolaus
authors.initials: N
authors.lastname: Becker
authors.forename: Angela
authors.initials: A
authors.lastname: Brooks-Wilson
authors.forename: John D
authors.initials: JD
authors.lastname: Curry
authors.forename: John J
authors.initials: JJ
authors.lastname: Spinelli
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Holly
authors.forename: Jacques
authors.initials: J
authors.lastname: Riby
authors.forename: Luoping
authors.initials: L
authors.lastname: Zhang
authors.forename: Alexandra
authors.initials: A
authors.lastname: Nieters
authors.forename: Martyn T
authors.initials: MT
authors.lastname: Smith
authors.forename: Kevin M
authors.initials: KM
authors.lastname: Brown
mesh_terms: D002896:Chromosomes, Human, Pair 6 / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006801:Humans; D008224:Lymphoma, Follicular / Q000235:genetics*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics