title: Nerve fibre layer thinning in patients with preclinical retinopathy.
abstract: OBJECTIVE
  To compare retinal nerve fibre layer thickness (RNFLT) obtained by optical coherence tomography (OCT) between patients with preclinical diabetic retinopathy (DR) and healthy subjects.
  
  
  METHODS
  Cross-sectional study.
  
  
  METHODS
  Ninety-nine type I or II diabetic patients with no visible funduscopic retinal alteration and 77 healthy subjects were included in this study.
  
  
  METHODS
  All participants were evaluated for peripapillary RNFLT by Stratus OCT. In diabetic patients, levels of blood sugar and glycosylated hemoglobin were examined.
  
  
  RESULTS
  The mean RNFLT in diabetic patients and healthy subjects was significantly different (104.2 [SD 10.4] and 108.6 [SD 9.2] microm, respectively; p = 0.004). Compared with the healthy group, the RNFLT in the diabetic group was also significantly less in the superior quadrant and at the 5, 11, and 12 o'clock sectors (p = 0.04, 0.002, and 0.001, respectively). The average RNFLT in diabetic patients with preclinical DR showed a low correlation with fasting blood sugar level (p = 0.03).
  
  
  CONCLUSIONS
  The mean and superior quadrant peripapillary RNFLT was slightly less in diabetic patients without abnormal vascular manifestations than in healthy subjects. Furthermore, lower RNFLT values in patients with preclinical DR appears to be weakly associated with high levels of fasting blood sugar.
authors.affiliation: Department of Ophthalmology, Shin-Kong Wu Ho-Su Memorial Hospital, #95 Wen-Chang Road, Taipei, Taiwan. paihuei@yahoo.com.tw
authors.forename: Pai-Huei
authors.initials: PH
authors.lastname: Peng
authors.forename: Huey-Shyan
authors.initials: HS
authors.lastname: Lin
authors.forename: Shan
authors.initials: S
authors.lastname: Lin
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D003430:Cross-Sectional Studies; D003922:Diabetes Mellitus, Type 1 / Q000175:diagnosis; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis; D003930:Diabetic Retinopathy / Q000175:diagnosis*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D009898:Optic Disk / Q000473:pathology*; D009901:Optic Nerve Diseases / Q000175:diagnosis*; D012165:Retinal Ganglion Cells / Q000473:pathology*; D041623:Tomography, Optical Coherence
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human