title: Normal pregnancy after tetraploid karyotype on trophectoderm biopsy.
abstract: OBJECTIVE
  To report a case of successful pregnancy after trophectoderm biopsy and fluorescence in situ hybridization (FISH) revealed a tetraploid karyotype.
  
  
  METHODS
  Case report.
  
  
  METHODS
  A university medical center.
  
  
  METHODS
  An infertility patient desiring trophectoderm biopsy on frozen blastocysts to facilitate preimplantation genetic screening.
  
  
  METHODS
  Frozen blastocysts were thawed on the evening before transfer. Trophectoderm biopsy was performed the following morning. FISH results were available the same day, and two embryos with tetraploid results were transferred.
  
  
  METHODS
  Chorionic villus sample (CVS) and newborn exam.
  
  
  RESULTS
  Normal diploid CVS result and a healthy male infant.
  
  
  CONCLUSIONS
  Although multiple cells can be analyzed using trophectoderm biopsy, abnormalities in the trophectoderm may not be present in the inner cell mass.
authors.affiliation: Division of Reproductive Endocrinology and Infertility, Stanford Hospital and Clinics, Palo Alto, California.
authors.forename: Sacha A
authors.initials: SA
authors.lastname: Krieg
authors.affiliation: Division of Reproductive Endocrinology and Infertility, Stanford Hospital and Clinics, Palo Alto, California.
authors.forename: Ruth B
authors.initials: RB
authors.lastname: Lathi
authors.affiliation: Division of Reproductive Endocrinology and Infertility, Stanford Hospital and Clinics, Palo Alto, California.
authors.forename: Barry
authors.initials: B
authors.lastname: Behr
authors.affiliation: Division of Reproductive Endocrinology and Infertility, Stanford Hospital and Clinics, Palo Alto, California. Electronic address: lynnw@stanford.edu.
authors.forename: Lynn M
authors.initials: LM
authors.lastname: Westphal
mesh_terms: D000328:Adult; D001706:Biopsy; D001755:Blastocyst / Q000473:pathology*; D002869:Chromosome Aberrations; D004475:Ectoderm / Q000473:pathology*; D004624:Embryo Transfer; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007231:Infant, Newborn; D007247:Infertility, Female / Q000628:therapy; D008297:Male; D011003:Ploidies; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000235:genetics*; D019836:Preimplantation Diagnosis / Q000379:methods*