title: [The main stages in the history of systemic lupus erythematosus].
abstract: Systemic lupus erythematosus can be considered the most characteristic and important among the connective tissue diseases. In this short review the main stages of its history are sketched, from the introduction of the term "lupus", traditionally attributed to Roger Frugardi, in 1230 (but in fact already documented in the 10th century) to the actual knowledge of its clinical and laboratory aspects. Initially considered exclusively of dermatological interest, the first to describe a systemic form with visceral involvement were Moriz Kohn Kaposi and William Osler. Significant contribution was also given by serological diagnosis, and in particular, by the identification of specific markers of disease, such as anti-native DNA and anti-Sm antibodies, allowing early diagnosis and the establishment of an adequate therapy.
authors.affiliation: Cattedra e U.O.C. di Reumatologia, Università di Padova, Padova, Italia.
authors.forename: M
authors.initials: M
authors.lastname: Rampudda
authors.forename: P
authors.initials: P
authors.lastname: Marson
authors.forename: G
authors.initials: G
authors.lastname: Pasero
mesh_terms: D000974:Antibodies, Antinuclear / Q000266:history / Q000276:immunology; D003937:Diagnosis, Differential; D049669:History, 16th Century; D049670:History, 17th Century; D049671:History, 18th Century; D049672:History, 19th Century; D049673:History, 20th Century; D049690:History, Ancient; D049691:History, Medieval; D006801:Humans; D007558:Italy; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis / Q000266:history* / Q000276:immunology; D009626:Terminology as Topic
chemical_list: D000974:Antibodies, Antinuclear