title: Adolescent idiopathic scoliosis and the single-nucleotide polymorphism of the growth hormone receptor and IGF-1 genes.
abstract: The etiology of adolescent idiopathic scoliosis is undetermined despite years of research. A number of hypotheses have been postulated to explain its development, including growth abnormalities. The irregular expression of growth hormone and insulin-like growth factor-1 (IGF-1) may disturb hormone metabolism, result in a gross asymmetry, and promote the progress of adolescent idiopathic scoliosis. Initial association studies in complex diseases have demonstrated the power of candidate gene association. Prior to our study, 1 study in this field had a negative result. A replicable study is vital for reliability. To determine the relationship of growth hormone receptor and IGF-1 genes with adolescent idiopathic scoliosis, a population-based association study was performed. Single nucleotide polymorphisms with potential function were selected from candidate genes and a distribution analysis was performed. A conclusion was made confirming the insufficiency of an association between adolescent idiopathic scoliosis and the single-nucleotide polymorphism of the growth hormone receptor and IGF-1 genes in Han Chinese.
authors.affiliation: Chinese Academy of Medical Sciences, Department of Orthopedics, Peking Union Medical College, Beijing, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Yang
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Wu
authors.forename: Taimao
authors.initials: T
authors.lastname: Zhao
authors.forename: Hai
authors.initials: H
authors.lastname: Wang
authors.forename: Dong
authors.initials: D
authors.lastname: Zhao
authors.forename: Jianguo
authors.initials: J
authors.lastname: Zhang
authors.forename: Yipeng
authors.initials: Y
authors.lastname: Wang
authors.forename: Yaozhong
authors.initials: Y
authors.lastname: Ding
authors.forename: Guixing
authors.initials: G
authors.lastname: Qiu
mesh_terms: D000293:Adolescent; D002648:Child; D002681:China / Q000453:epidemiology; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology* / Q000235:genetics*; D006801:Humans; D015994:Incidence; D007334:Insulin-Like Growth Factor I / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011986:Receptors, Somatotropin / Q000235:genetics*; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors; D012600:Scoliosis / Q000453:epidemiology* / Q000235:genetics*; D055815:Young Adult
chemical_list: D011986:Receptors, Somatotropin; D007334:Insulin-Like Growth Factor I