title: Clinical impact of early clopidogrel discontinuation following acute myocardial infarction hospitalization or stent implantation: analysis in a nationally representative managed-care population.
abstract: OBJECTIVE
  To evaluate the association between discontinuation of clopidogrel therapy and risk of acute myocardial infarction (AMI) hospitalization or cardiac revascularization in a nationally-representative patient population following hospitalization for an AMI or coronary stent insertion.
  
  
  METHODS
  This observational cohort study was performed using data on patients from the PharMetrics Anonymous Patient-Centric Database who were hospitalized for an AMI or coronary stent insertion and subsequently treated with clopidogrel. Cox proportional hazard modeling was used to evaluate the association between clopidogrel discontinuation prior to 1 year post-initial AMI hospitalization and the primary endpoint of repeat AMI hospitalization or coronary intervention defined as percutaneous coronary intervention (PCI) with or without stent, or coronary artery bypass graft (CABG).
  
  
  METHODS
  The main outcome for this study was AMI hospitalization or coronary intervention defined as PCI with or without stent placement or CABG.
  
  
  RESULTS
  A total of 31 835 patients were included in the analyses. Patients were predominantly male and the average patient age was approximately 60 years. After controlling for baseline patient characteristics and follow-up time, discontinuation of clopidogrel was associated with a significantly higher rate of hospitalization for AMI or coronary intervention (HR 1.34, 95% CI 1.22-1.44).
  
  
  CONCLUSIONS
  Within a population of ACS patients drawn from a database of 85 US health plans, clopidogrel discontinuation within 1 year following hospitalization for AMI or stent placement is associated with an increased risk of AMI hospitalization or coronary intervention. The results of this study should be interpreted within the context of observational research, which does not address cause and effect relationships.
authors.affiliation: Analytica International, New York, NY, USA. DWiederkehr@analyticaintl.com
authors.forename: Daniel
authors.initials: D
authors.lastname: Wiederkehr
authors.forename: Augustina
authors.initials: A
authors.lastname: Ogbonnaya
authors.forename: Roman
authors.initials: R
authors.lastname: Casciano
authors.forename: Dinara
authors.initials: D
authors.lastname: Makenbaeva
authors.forename: Essy
authors.initials: E
authors.lastname: Mozaffari
authors.forename: John
authors.initials: J
authors.lastname: Corbelli
mesh_terms: D000368:Aged; D000465:Algorithms; D013504:Cardiovascular Surgical Procedures / Q000706:statistics & numerical data; D000077144:Clopidogrel; D015331:Cohort Studies; D003327:Coronary Disease / Q000209:etiology / Q000401:mortality / Q000601:surgery*; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D008329:Managed Care Programs; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology / Q000209:etiology / Q000401:mortality / Q000628:therapy*; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D011153:Population; D012189:Retrospective Studies; D012307:Risk Factors; D015607:Stents; D013988:Ticlopidine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D013997:Time Factors; D014481:United States; D028761:Withholding Treatment / Q000706:statistics & numerical data
chemical_list: D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D013988:Ticlopidine