title: Multicomponent reactions for the synthesis of multifunctional agents with activity against cancer cells.
abstract: Multicomponent Passerini and Ugi reactions enable the fast and efficient synthesis of redox-active multifunctional selenium and tellurium compounds, of which some show considerable cytotoxicity against specific cancer cells.
authors.affiliation: Division of Bioorganic Chemistry, School of Pharmacy, Saarland University, D-66123 Saarbruecken, Germany.
authors.forename: Saad
authors.initials: S
authors.lastname: Shabaan
authors.forename: Lalla A
authors.initials: LA
authors.lastname: Ba
authors.forename: Muhammad
authors.initials: M
authors.lastname: Abbas
authors.forename: Torsten
authors.initials: T
authors.lastname: Burkholz
authors.forename: Annika
authors.initials: A
authors.lastname: Denkert
authors.forename: André
authors.initials: A
authors.lastname: Gohr
authors.forename: Ludger A
authors.initials: LA
authors.lastname: Wessjohann
authors.forename: Florenz
authors.initials: F
authors.lastname: Sasse
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Weber
authors.forename: Claus
authors.initials: C
authors.lastname: Jacob
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry; D045744:Cell Line, Tumor; D006801:Humans; D020128:Inhibitory Concentration 50; D051379:Mice; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D010084:Oxidation-Reduction; D012643:Selenium / Q000737:chemistry*; D013691:Tellurium / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D009942:Organometallic Compounds; D012643:Selenium; D013691:Tellurium