Rejuvenation of the aging T cell compartment.
The elderly face significant risk for susceptibility to infection and cancer because of declining immune function. Various agents used in the setting of bone marrow transplantation and aging studies represent promising approaches to combating T cell defects in the aging population. Preclinical and clinical studies on the T cell reconstitution effects of sex steroid ablation, keratinocyte growth factor, the growth hormone pathway, and the cytokines interleukin-7, interleukin-12, and interleukin-15 indicate that these strategies may be used to alleviate the effects of T cell deficiencies in the elderly.
Holland
Amanda M
AM
Department of Immunology and Microbial Pathogenesis, Weill Cornell Medical College, New York, NY 10021, USA.
van den Brink
Marcel R M
MR
D000375:Aging / Q000502:physiology*; D000818:Animals; D016026:Bone Marrow Transplantation; D016207:Cytokines / Q000502:physiology; D051523:Fibroblast Growth Factor 7 / Q000502:physiology; D012739:Gonadal Steroid Hormones / Q000502:physiology; D013006:Growth Hormone / Q000502:physiology; D048091:Guided Tissue Regeneration; D006801:Humans; D007108:Immune Tolerance; D007334:Insulin-Like Growth Factor I / Q000502:physiology; D051379:Mice; D012060:Rejuvenation; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism / Q000473:pathology*
D016207:Cytokines; C496453:FGF7 protein, human; D012739:Gonadal Steroid Hormones; D051523:Fibroblast Growth Factor 7; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone