title: Application of beta-(2-chloroaroyl)thioacetanilide in synthesis(III): an efficient three-component synthesis of thiochromeno[2,3-b]pyridines catalyzed by KF/neutral Al2O3 co-operated with PEG 6000 under microwave irradiation.
abstract: A series of new functionalized thiochromeno[2,3-b]pyridine derivatives have been synthesized via a sequence of Knoevenagel condensation, Michael addition, cyclization, and intramolecular nucleophilic substitution, which is first catalyzed by KF/neutral Al(2)O(3) cooperated with PEG 6000 under microwave irradiation. Experimental results indicated that among the catalysts tested, KF/ neutral Al(2)O(3) with PEG 6000 exhibits the best catalytic activity, which leads to a substantial improvement in the overall yield and purity of the desired final products and significantly shorter reaction time.
authors.affiliation: Key Laboratory of Eco-Chemical Engineering, Ministry of Education, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, PR China.
authors.forename: Lirong
authors.initials: L
authors.lastname: Wen
authors.forename: Chen
authors.initials: C
authors.lastname: Ji
authors.forename: Yafeng
authors.initials: Y
authors.lastname: Li
authors.forename: Ming
authors.initials: M
authors.lastname: Li
mesh_terms: D000083:Acetanilides / Q000737:chemistry*; D000537:Aluminum Oxide / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D005459:Fluorides / Q000737:chemistry*; D008872:Microwaves; D011092:Polyethylene Glycols / Q000737:chemistry*; D017680:Potassium Compounds / Q000737:chemistry*; D011725:Pyridines / Q000138:chemical synthesis*
chemical_list: D000083:Acetanilides; D017680:Potassium Compounds; D011725:Pyridines; C545232:beta-(2-chloroaroyl)thioacetanilide; D011092:Polyethylene Glycols; C033320:potassium fluoride; D000537:Aluminum Oxide; D005459:Fluorides