Genomic amplicons target vesicle recycling in breast cancer.
Aberrant endocytosis, vesicle targeting, and receptor recycling represent emerging hallmarks of cancer. In this issue of the JCI, Zhang and colleagues demonstrate that RAB-coupling protein (RCP; also known as RAB11FIP1) is a "driver" of the 8p11-12 amplicon in human breast cancer and mouse xenograft models of mammary carcinogenesis (see the related article beginning on page 2171). Their finding that RAB GTPase function enables genomic amplification to confer aggressiveness to mammary tumors adds significantly to the body of evidence supporting pivotal roles for receptor trafficking in the proliferation and metastasis of cancer.
Mills
Gordon B
GB
Department of Systems Biology, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA. gmills@mdanderson.org
Jurisica
Igor
I
Yarden
Yosef
Y
Norman
Jim C
JC
D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics* / Q000502:physiology; D000465:Algorithms; D000818:Animals; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D002465:Cell Movement; D005260:Female; D005784:Gene Amplification; D018734:Genes, erbB-2; D006801:Humans; D039081:Integrin alpha5beta1 / Q000502:physiology; D019012:Integrin beta1 / Q000502:physiology; D008565:Membrane Proteins / Q000235:genetics* / Q000502:physiology; D051379:Mice; D009361:Neoplasm Invasiveness; D009857:Oncogenes; D020691:rab GTP-Binding Proteins / Q000235:genetics
D048868:Adaptor Proteins, Signal Transducing; D039081:Integrin alpha5beta1; D019012:Integrin beta1; D008565:Membrane Proteins; C488966:RAB11FIP1 protein, human; C509763:Rab25 protein, human; D020691:rab GTP-Binding Proteins