Antioxidant and antidermatophytic activities of essential oil and extracts of Magnolia liliflora Desr.
This study was carried out to assess the antioxidant and antidermatophytic activities of the essential oil and extracts of Magnolia liliflora Desr. Antioxidant activity was evaluated by using 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. The free radical scavenging activities of the oil and ethyl acetate extract were found to be superior (IC(50) values=10.11 and 16.17 microg/ml, respectively) as compared to butylatedhydreoxyanisole (BHA), (IC(50) value=18.27 microg/ml). Also the ethyl acetate extract revealed the highest phenolic contents (96.13 mg/g of dry wt) as compared to the other extracts. Further, the oil (1000 microg/disc) and extracts (1500 microg/disc) revealed 42.36-63.12% and 19.07-54.14% antidermatophytic effect, respectively along with their respective MIC values ranging from 62.5 to 500 and 250 to 2000 microg/ml against the members of Trichophyton and Microsporum spp. Also the oil had strong detrimental effect on spore germination of tested fungal pathogens as well as concentration and time dependent kinetic inhibition of Microsporum canis KCTC 6348. The results of this study justify a potential role of M. liliflora to serve as a natural antioxidant and antidermatophytic agent.
Bajpai
Vivek K
VK
Department of Biotechnology, Daegu University, Kyoungsan, Kyoungbook 712-714, Republic of Korea.
Yoon
Jung In
JI
Kang
Sun Chul
SC
D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000737:chemistry; D002083:Butylated Hydroxyanisole / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000737:chemistry / Q000494:pharmacology*; D005609:Free Radicals / Q000737:chemistry; D031566:Magnolia / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D008864:Microsporum / Q000187:drug effects; D009822:Oils, Volatile / Q000737:chemistry / Q000494:pharmacology*; D010636:Phenols / Q000032:analysis; D010851:Picrates / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D014249:Trichophyton / Q000187:drug effects
D000935:Antifungal Agents; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D005609:Free Radicals; D009822:Oils, Volatile; D010636:Phenols; D010851:Picrates; D010936:Plant Extracts; D002083:Butylated Hydroxyanisole; C004931:1,1-diphenyl-2-picrylhydrazyl