[Assessment of safety of lyophilized substance of antibacterial peptide complex].
OBJECTIVE
To assessment acute and chronic toxicity and local irritative effect of antibacterial peptide complex (ABC) substance extracted from interferon preparations.


METHODS
Preclinical assessment of ABC substance was performed according to "Requirements for preclinical study of overall toxicity of new pharmacological substances".


RESULTS
Series of experiments showed that single or prolonged (during 30 days) administration of ABC substance solution to mice intragastrically or rectally in maximal doses did not lead to death of experimental animals or pathological changes in their organs during pathomorphological and histological studies. Assessment of immune system state showed that administration of solution of studied substance during 1 month in dose 25 times higher than therapeutic leaded to stimulation of phagocytic activity of peripheral blood neutrophils.


CONCLUSIONS
Assessment of acute and chronic toxicity showed that substance of ABC synthesized by virus-induced donor leukocytes during interferon synthesis is well tolerated by experimental animals, does not render toxic effects on their organisms, and possesses immunomodulating activity.
Volkova
L V
LV
Kaz'ianin
A V
AV
Tiureva
T A
TA
Pestereva
S A
SA
D000818:Animals; D000900:Anti-Bacterial Agents / Q000276:immunology / Q000494:pharmacology / Q000633:toxicity*; D023181:Antimicrobial Cationic Peptides / Q000276:immunology / Q000494:pharmacology / Q000633:toxicity*; D005612:Freeze Drying; D007155:Immunologic Factors / Q000494:pharmacology / Q000633:toxicity*; D007372:Interferons / Q000737:chemistry; D051379:Mice; D009504:Neutrophils / Q000276:immunology; D010587:Phagocytosis / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar
D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; D007155:Immunologic Factors; D007372:Interferons