An unexpectedly facile cyclization of polyhydric alcohols.
Contrary to previous reports in the literature, the reaction of polyhydric alcohols such as sorbitol or mannitol gives good yields of the tetrahydroxyoxepane derivative in the presence of an acid catalyst, in refluxing toluene, with complete retention of stereochemistry.
Pavlik
Christopher
C
Department of Chemistry, University of Connecticut, 55 N. Eagleville Road, Storrs, Connecticut 06269-3060, USA.
Onorato
Amber
A
Castro
Steve
S
Morton
Martha
M
Peczuh
Mark
M
Smith
Michael B
MB