title: C-reactive protein predicts long-term mortality independently of low-density lipoprotein cholesterol in patients undergoing percutaneous coronary intervention.
abstract: BACKGROUND
  Few data are available on the association of high-sensitivity C-reactive protein (hs-CRP) and mortality independent of low-density lipoprotein (LDL) cholesterol in patients undergoing percutaneous coronary intervention (PCI).
  
  
  METHODS
  Consecutive patients (N = 8,834) undergoing PCI between October 28, 2002, and December 31, 2006, were followed through June 30, 2007 (average and maximum follow-up of 1.9 and 4.6 years, respectively). High-sensitivity CRP levels were classified into 4 groups: <1.0, 1.0 to 2.9, 3.0 to 9.9, and > or =10 mg/L.
  
  
  RESULTS
  All-cause mortality rates were 14.4, 17.5, 25.7, and 56.4 per 1,000 person-years in patients with hs-CRP levels of <1.0, 1.0 to 2.9, 3.0 to 9.9, and > or =10 mg/L, respectively. Compared with patients with hs-CRP <1.0 mg/L, the hazard ratios of mortality after multivariable adjustment, including LDL cholesterol, associated with hs-CRP levels of 1.0 to 2.9, 3.0 to 9.9, and > or =10 mg/L were 1.27 (95% CI 0.91-1.75), 1.70 (95% CI 1.26-2.29), and 2.99 (95% CI 2.24-3.99), respectively (P trend < .001). After multivariable adjustment, trends of higher all-cause mortality at higher hs-CRP were present for patients with LDL cholesterol <70, 70 to 99, and > or =100 mg/dL (each P < .001). A test for interaction between LDL cholesterol and hs-CRP on all-cause mortality was not significant (P = .30).
  
  
  CONCLUSIONS
  High-sensitivity CRP levels provide significant incremental prognostic information for all-cause mortality in long-term follow-up independent of LDL cholesterol.
authors.affiliation: Cardiac Catheterization Laboratory and Clinical Trials Unit, Cardiovascular Institute, Mount Sinai Heart, New York, NY, USA.
authors.forename: Louai
authors.initials: L
authors.lastname: Razzouk
authors.forename: Paul
authors.initials: P
authors.lastname: Muntner
authors.forename: Sameer
authors.initials: S
authors.lastname: Bansilal
authors.forename: Annapoorna S
authors.initials: AS
authors.lastname: Kini
authors.forename: Ashish
authors.initials: A
authors.lastname: Aneja
authors.forename: Joshua
authors.initials: J
authors.lastname: Mozes
authors.forename: Oana
authors.initials: O
authors.lastname: Ivan
authors.forename: Madhavi
authors.initials: M
authors.lastname: Jakkula
authors.forename: Samin
authors.initials: S
authors.lastname: Sharma
authors.forename: Michael E
authors.initials: ME
authors.lastname: Farkouh
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D002097:C-Reactive Protein / Q000032:analysis*; D008078:Cholesterol, LDL / Q000097:blood*; D003327:Coronary Disease / Q000097:blood / Q000401:mortality / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood* / Q000401:mortality* / Q000628:therapy; D011237:Predictive Value of Tests; D011379:Prognosis; D016016:Proportional Hazards Models
chemical_list: D008078:Cholesterol, LDL; D002097:C-Reactive Protein