title: [Effects of Ginkgo biloba extract (EGB) on acute myocardial ischemia induced by isoproterenol in rats].
abstract: OBJECTIVE
  To investigate the therapeutic effects of Ginkgo biloba extract (EGb) in rats with acute myocardial injury induced by isoproterenol (ISO).
  
  
  METHODS
  The rats, induced by Isoproterenol (4 mg x kg(-1) x d(-1), 10 d, sc), were divided into groups: sham, model, metoprolol (10 mg x kg(-1) x d(-1), 13 d, ig), EGb (100 mg x kg(-1) x d(-1), 13 d, ig).
  
  
  RESULTS
  The cardiac parameters of the Model group were compromised significantly in both systolic and diastolic function. Improvement in cardiac function by EGb was significant. In model groups, plasma activities of AST, LDH, CK, HBDH, CKMB and ventricular weight index (LV and RV/BW) were elevated significantly. With the treatment with EGb and metoprolol, the enzymes and ventricular weight index were significantly ameliorated.
  
  
  CONCLUSIONS
  G. biloba extract was beneficial to cardiac performance by improving myocardium enzymes and cardiac function in isoproterenol induced myocardial injury in rats.
authors.affiliation: Nanjing Normal University, Nanjing 210046, China. dingfuyun123@163.com
authors.forename: Fuyun
authors.initials: F
authors.lastname: Ding
authors.forename: Yongqing
authors.initials: Y
authors.lastname: Wang
authors.forename: Yun
authors.initials: Y
authors.lastname: Liu
authors.forename: Weifeng
authors.initials: W
authors.lastname: Yao
authors.forename: Shuqin
authors.initials: S
authors.lastname: Yu
authors.forename: Guanglin
authors.initials: G
authors.lastname: Xu
mesh_terms: D000818:Animals; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D020441:Ginkgo biloba / Q000737:chemistry*; D006439:Hemodynamics / Q000187:drug effects; D007545:Isoproterenol / Q000009:adverse effects*; D008297:Male; D017202:Myocardial Ischemia / Q000139:chemically induced* / Q000188:drug therapy* / Q000201:enzymology / Q000503:physiopathology; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D004365:Drugs, Chinese Herbal; D007545:Isoproterenol