title: Sleep timing and circadian phase in delayed sleep phase syndrome.
abstract: Delayed sleep phase syndrome (DSPS) is a circadian rhythm sleep disorder in which the timing of the sleep episode occurs later than desired and is associated with difficulty falling asleep, problems awakening on time (e.g., to meet work or school obligations), and daytime sleepiness. The phase relationship between the timing of sleep and endogenous circadian rhythms is critical to the initiation and maintenance of sleep, and significant alteration leads to impairment of sleep quality and duration. The aim of this retrospective study was to determine the phase relationship between sleep-wake times and physiological markers of circadian timing in clinic patients with DSPS. Objective and subjective measures of sleep timing and circadian phase markers (core body temperature and melatonin) were measured in patients with DSPS and compared with age-matched controls. As expected, significant delays in the timing of the major sleep episode and circadian phase of body temperature and melatonin rhythms were seen in the DSPS group when allowed to sleep at their own habitual schedules, but the phase relationship between sleep-wake times and circadian phase was similar between the 2 groups. These results suggest that the symptoms of insomnia and excessive daytime sleepiness in DSPS patients living under entrained real-life conditions cannot be explained by an alteration in the phase relationship between sleep-wake patterns and other physiological circadian rhythms.
authors.affiliation: Harvard Medical School, Brigham and Women's Hospital, Department of Medicine, Boston, MA 02115, USA. amchang@rics.bwh.harvard.edu
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Chang
authors.forename: Kathryn J
authors.initials: KJ
authors.lastname: Reid
authors.forename: Ramadevi
authors.initials: R
authors.lastname: Gourineni
authors.forename: Phyllis C
authors.initials: PC
authors.lastname: Zee
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000032:analysis / Q000097:blood; D001831:Body Temperature; D002940:Circadian Rhythm / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008550:Melatonin / Q000032:analysis / Q000097:blood; D008875:Middle Aged; D012189:Retrospective Studies; D012890:Sleep / Q000502:physiology*; D020178:Sleep Disorders, Circadian Rhythm / Q000378:metabolism / Q000503:physiopathology*; D007319:Sleep Initiation and Maintenance Disorders / Q000378:metabolism / Q000503:physiopathology; D013997:Time Factors; D014851:Wakefulness / Q000502:physiology; D055815:Young Adult
chemical_list: D015415:Biomarkers; D008550:Melatonin