[Effects of human urinary tissue kallikreins on vasodilation of basilar artery in rabbits with symptomatic cerebral vasospasm].
OBJECTIVE
To evaluate the effects of urinary kallidinogenase on subarachnoid hemorrhage (SAH) in rabbits.


METHODS
Rabbits symptomatic cerebral vasospasm model was built though Endo method, among the 40 rabbits, 8 died or had severe nervous system syndrome, the other 32 were randomly divided into 4 groups:group A, control group, injection of normal saline to the cisterna magna;group B, subarachnoid hemorrhage;group C, injection of human urinary tissue kallikreins;group D, treated with Nimodipine. The behavior scores, neurological scores and cerebral angiography changes were observed.


RESULTS
Food intake obviously decreased and neurological deficit were seen in group B, while which were attenuated in group C and group D, and group A was normal. Comparing the diameter of basilar artery was (1.9 +/- 0.3) mm before SAH, the diameter of group B 4 d later was (1.5 +/- 0.3) mm, 7 d later (1.4 +/- 0.3) mm, the difference was significant (P < 0.05). Comparing with group C on the day 4th and 7th, the diameters of basilar artery were significantly different (P < 0.001). Comparing with group D on the day 4th, 7th and 14th, there was no obvious improvement.


CONCLUSIONS
Urinary kallidinogenase and Nimodipine can obviously alleviate symptomatic cerebral vasospasm in rabbits remarkably, but the former's effect of attenuating vasospasm is better than that of Nimodipine.
Pei
Sheng-Lin
SL
Department of Anesthesiology, the First Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000, China.
Meng
Yi-Nan
YN
Wang
Jun-Lu
JL
Hu
Zhang-Yong
ZY
Mo
Yun-Chang
YC
Zhou
Le-Ping
LP
Chen
Wei-Jian
WJ
D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D008297:Male; D009553:Nimodipine / Q000627:therapeutic use; D011817:Rabbits; D011897:Random Allocation; D020840:Tissue Kallikreins / Q000627:therapeutic use*; D014665:Vasodilator Agents / Q000627:therapeutic use*; D020301:Vasospasm, Intracranial / Q000188:drug therapy*
D014665:Vasodilator Agents; D009553:Nimodipine; D020840:Tissue Kallikreins