title: Muscle fibers inside a fat tumor: a non-specific imaging finding of benignancy.
abstract: BACKGROUND
  The differential diagnosis between benign and low-grade well-differentiated malignant lipomatous tumors might be very difficult for both the radiologist and the pathologist, although it has practical consequences. Among the criteria, muscular fibers detected inside the lesion are considered radiologically and histologically as a reliable sign of a benign intramuscular lipoma. New genetic criteria are now available. We report two cases of fat tumors containing muscular fibers both radiologically and histologically, but which are definitely malignant, considering genetic criteria.
  
  
  METHODS
  Two cases of soft tissue fat tumors, containing muscular fibers on imaging examinations as well as histologically, had an aggressive behaviour, suggesting malignancy. Genetic criteria were therefore used to confirm the clinical impression.
  
  
  RESULTS
  MDM2 and CDK4 confirmed the malignancy in the two cases.
  
  
  CONCLUSIONS
  Intra lesional muscular fibers detected on imaging or histological examinations should not be considered as a completely reliable sign of a benign intramuscular lipoma. In case of atypical clinical behaviour, genetic criteria should be used to prove the aggressiveness of the tumor.
authors.affiliation: Department of Anatomical Pathology Hospital Dr. R.A Calderón Guardia, Universidad De Costa Rica, P.O. Box 6098-1000, San José, Costa Rica.
authors.forename: M
authors.initials: M
authors.lastname: Donato
authors.forename: D
authors.initials: D
authors.lastname: Vanel
authors.forename: M
authors.initials: M
authors.lastname: Alberghini
authors.forename: M
authors.initials: M
authors.lastname: Mercuri
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008067:Lipoma / Q000175:diagnosis*; D008080:Liposarcoma / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging; D008297:Male; D018485:Muscle Fibers, Skeletal / Q000473:pathology*; D019042:Muscle Neoplasms / Q000175:diagnosis*