title: Antioxidative effect of royal jelly in cisplatin-induced testes damage.
abstract: OBJECTIVE
  To investigate the antioxidative effect of royal jelly on cisplatin (CP)-induced spermiotoxicity using quantitative, biochemical, and histopathologic approaches.
  
  
  METHODS
  CP was administered to rats at a single dose of 7 mg/kg i.p. Royal jelly was administered by gavage daily for 10 days at doses of 50 and 100 mg/kg. Traits of reproductive organs, such as sperm characteristics, testicular histologic findings, plasma testosterone levels, and testicular tissue oxidative stress status were determined.
  
  
  RESULTS
  Royal jelly ameliorated the CP-induced reductions in weights of testes, epididymides, seminal vesicles, and prostate along with epididymal sperm concentration and motility. An increase in testes malondialdehyde concentrations (P <.05) were detected, while significant decreases in superoxide dismutase, catalase, and glutathione-peroxidase levels were noted in CP-alone group compared with control group. The administration of royal jelly to CP-treated rats decreased the malondialdehyde level and increased superoxide dismutase, catalase, and glutathione-peroxidase activities in the samples.
  
  
  CONCLUSIONS
  The CP-induced changes in histopathologic findings of testis were partially reversed by treatment with royal jelly. The results provide further insight into the mechanisms of CP-induced sperm toxicity and confirm the antioxidant potential of royal jelly.
authors.affiliation: Department of Animal Science, S Cikrikcioglu Vocational College, University of Erciyes, Kayseri, Turkey.
authors.forename: Sibel
authors.initials: S
authors.lastname: Silici
authors.forename: Oguz
authors.initials: O
authors.lastname: Ekmekcioglu
authors.forename: Gokhan
authors.initials: G
authors.lastname: Eraslan
authors.forename: Abdullah
authors.initials: A
authors.lastname: Demirtas
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects*; D005227:Fatty Acids / Q000627:therapeutic use*; D007301:Insect Hormones / Q000627:therapeutic use*; D008297:Male; D018384:Oxidative Stress; D051381:Rats; D017208:Rats, Wistar; D013733:Testicular Diseases / Q000139:chemically induced* / Q000378:metabolism / Q000517:prevention & control*; D013737:Testis / Q000187:drug effects* / Q000473:pathology; D000099219:Royal Jelly
chemical_list: D000975:Antioxidants; D002945:Cisplatin; D005227:Fatty Acids; D007301:Insect Hormones; D000099219:Royal Jelly