title: Endovascular treatment options in the management of lower limb deep venous thrombosis.
abstract: Lower limb deep vein thrombosis (DVT) is a common cause of significant morbidity and mortality. Systemic anticoagulation therapy is the mainstay of conventional treatment instituted by most physicians for the management of DVT. This has proven efficacy in the prevention of thrombus extension and reduction in the incidence of pulmonary embolism and rethrombosis. Unfortunately, especially in patients with severe and extensive iliofemoral DVT, standard treatment may not be entirely adequate. This is because a considerable proportion of these patients eventually develops postthrombotic syndrome. This is characterized by chronic extremity pain and trophic skin changes, edema, ulceration, and venous claudication. Recent interest in endovascular technologies has led to the development of an assortment of minimally invasive, catheter-based strategies to deal with venous thrombus. These comprise catheter-directed thrombolysis, percutaneous mechanical thrombectomy devices, adjuvant venous angioplasty and stenting, and inferior vena cava filters. This article reviews these technologies and discusses their current role as percutaneous treatment strategies for venous thrombotic conditions.
authors.affiliation: Department of Radiology, John Radcliffe Hospital, Headley Way, Oxford, UK. sarfraznazir@doctors.org.uk
authors.forename: Sarfraz Ahmed
authors.initials: SA
authors.lastname: Nazir
authors.forename: Arul
authors.initials: A
authors.lastname: Ganeshan
authors.forename: Sheraz
authors.initials: S
authors.lastname: Nazir
authors.forename: Raman
authors.initials: R
authors.lastname: Uberoi
mesh_terms: D017130:Angioplasty / Q000379:methods*; D000925:Anticoagulants / Q000008:administration & dosage; D002404:Catheterization / Q000379:methods*; D006801:Humans; D007866:Leg / Q000098:blood supply*; D019060:Minimally Invasive Surgical Procedures; D015607:Stents; D017131:Thrombectomy / Q000379:methods*; D015912:Thrombolytic Therapy / Q000379:methods*; D016306:Vena Cava Filters; D020246:Venous Thrombosis / Q000628:therapy*
chemical_list: D000925:Anticoagulants