Good syndrome accompanied by pure red cell aplasia.
Thymomas are often associated with various autoimmune disorders. We herein report a middle-aged female patient with thymoma and hypogammaglobulinemia (Good syndrome) who developed symptomatic normocytic anemia. Her computed tomography (CT) scans showed a cervico-mediastinal mass. The findings of a bone marrow biopsy suggested pure red cell aplasia (PRCA), and the serum levels of all immunoglobulins were extremely low. After the resection of the tumor, which was diagnosed to be Masaoka stage II and type AB thymoma, the normocytic anemia dramatically improved, but the hypogammaglobulinemia did not recover.
Taniguchi
Tetsuo
T
Division of Thoracic Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan. ttani@med.nagoya-u.ac.jp
Usami
Noriyasu
N
Kawaguchi
Koji
K
Yokoi
Kohei
K
D000328:Adult; D000361:Agammaglobulinemia / Q000097:blood / Q000175:diagnosis / Q000276:immunology*; D000368:Aged; D001706:Biopsy; D001856:Bone Marrow Examination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010257:Paraneoplastic Syndromes / Q000097:blood / Q000175:diagnosis / Q000276:immunology*; D012010:Red-Cell Aplasia, Pure / Q000097:blood / Q000175:diagnosis / Q000276:immunology*; D013934:Thymectomy; D013945:Thymoma / Q000097:blood / Q000175:diagnosis / Q000276:immunology* / Q000601:surgery; D013953:Thymus Neoplasms / Q000097:blood / Q000175:diagnosis / Q000276:immunology* / Q000601:surgery; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome