title: Aplastic anemia following varicella vaccine.
abstract: Varicella zoster vaccine is a safe vaccine that is rarely associated with life-threatening complications. We describe an immunocompetent child who developed transient severe aplastic anemia concomitant with a typical clinical and laboratory-proven chickenpox syndrome 3 weeks after immunization. A causative association between the vaccine and the hematologic disease is possible, and pediatricians should be aware of this severe although rare adverse event.
authors.affiliation: Division of Haematology and Oncology, Hospital for Sick Children, Toronto, Canada. paola.angelini@sickkids.ca
authors.forename: Paola
authors.initials: P
authors.lastname: Angelini
authors.forename: Fotini
authors.initials: F
authors.lastname: Kavadas
authors.forename: Navneet
authors.initials: N
authors.lastname: Sharma
authors.forename: Susan E
authors.initials: SE
authors.lastname: Richardson
authors.forename: Graham
authors.initials: G
authors.lastname: Tipples
authors.forename: Chaim
authors.initials: C
authors.lastname: Roifman
authors.forename: Yigal
authors.initials: Y
authors.lastname: Dror
authors.forename: Yehuda
authors.initials: Y
authors.lastname: Nofech-Mozes
mesh_terms: D000741:Anemia, Aplastic / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D019433:Chickenpox Vaccine / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D014645:Herpesvirus 3, Human / Q000235:genetics / Q000276:immunology; D006801:Humans; D016130:Immunophenotyping; D007223:Infant; D016133:Polymerase Chain Reaction; D012698:Serologic Tests
chemical_list: D019433:Chickenpox Vaccine