[Clinical evaluation of the antioxidant activity of astragalus in women with gestational diabetes].
OBJECTIVE
To evaluate the antioxidant activity of astragalus and its therapeutic effect on gestational diabetes.


METHODS
Eighty-four pregnant women with gestational diabetes were divided into insulin and insulin plus astragalus groups after regular dietary control and insulin treatment to maintain stable blood glucose level. The 43 patients in insulin group received insulin injection, whereas the 41 patients in the other group received treatment with both insulin and astragalus. The SOD activity, MDA level, blood lipids and renal function were determined in both groups after the treatments.


RESULTS
The patients with both insulin and astragalus treatments showed significantly increased serum SOD activity and decreased MDA level, renal function and blood lipids in comparison with those with exclusive insulin treatment.


CONCLUSIONS
Astragalus can effectively control blood glucose, reduce the free radicals, and promote the antioxidative activity, and may play a role in the prevention and treatment of gestational diabetes.
Liang
Hai-Ying
HY
Department of Gynecology and Obstetrics, Guangdong Women and Children's Hospital and Heath Institute, Guangzhou 510010, China.
Hou
Feng
F
Ding
Yong-Li
YL
Zhang
Wen-Ni
WN
Huang
Xiao-Hui
XH
Zhang
Bi-Yun
BY
Liu
Ying
Y
D000975:Antioxidants / Q000378:metabolism*; D027883:Astragalus Plant; D016640:Diabetes, Gestational / Q000188:drug therapy* / Q000378:metabolism*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008315:Malondialdehyde / Q000378:metabolism; D010084:Oxidation-Reduction; D008517:Phytotherapy; D011247:Pregnancy; D013482:Superoxide Dismutase / Q000378:metabolism; D016896:Treatment Outcome
D000975:Antioxidants; D004365:Drugs, Chinese Herbal; D008315:Malondialdehyde; D013482:Superoxide Dismutase