Gallbladder emptying in patients with primary sclerosing cholangitis.
OBJECTIVE
To assess gallbladder emptying and its association with cholecystitis and abdominal pain in patients with primary sclerosing cholangitis (PSC).


METHODS
Twenty patients with PSC and ten healthy subjects were investigated. Gallbladder fasting volume, ejection fraction and residual volume after ingestion of a test meal were compared in patients with PSC and healthy controls using magnetic resonance imaging. Symptoms, thickness and contrast enhancement of the gallbladder wall and the presence of cystic duct strictures were also assessed.


RESULTS
Median fasting gallbladder volume in patients with PSC [67 (19-348) mL] was twice that in healthy controls [32 (16-55) mL] (P < 0.05). The median postprandial gallbladder volume in patients with PSC was significantly larger than that in healthy controls (P < 0.05). There was no difference in ejection fraction, gallbladder emptying volume or mean thickness of the gallbladder wall between PSC patients and controls. Contrast enhancement of the gallbladder wall in PSC patients was higher than that in controls; (69% +/- 32%) and (42% +/- 21%) (P < 0.05). No significant association was found between the gallbladder volumes and occurrence of abdominal pain in patients and controls.


CONCLUSIONS
Patients with PSC have increased fasting gallbladder volume. Gallbladder Mucosal dysfunction secondary to chronic cholecystitis, may be a possible mechanism for increased gallbladder.
Said
Karouk
K
Department of Gastroenterology and Hepatology, Karolinska Institute, Karolinska University Hospital, Huddinge, 14186 Stockholm, Sweden. karouk.said@ki.se
Edsborg
Nick
N
Albiin
Nils
N
Bergquist
Annika
A
D000328:Adult; D015209:Cholangitis, Sclerosing / Q000473:pathology / Q000503:physiopathology; D005260:Female; D005704:Gallbladder / Q000033:anatomy & histology / Q000502:physiology; D016473:Gallbladder Emptying / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011795:Surveys and Questionnaires; D055815:Young Adult