title: Anticardiolipin antibodies in the sera of patients with diagnosed chronic fatigue syndrome.
abstract: Examination of anticardiolipin antibodies (ACAs) in the sera of patients clinically diagnosed with chronic fatigue syndrome (CFS) using an enzyme-linked immunoassay procedure demonstrated the presence of immunoglobulin M isotypes in 95% of CFS serum samples tested. The presence of immunoglobulin G and immunoglobulin A isotypes were also detected in a subset of the samples. Future studies will focus on elucidating whether alterations to mitochondrial inner membranes and/or metabolic functions play a possible role in the expression of ACAs.
authors.affiliation: Department of Pathology, John A. Burns School of Medicine, University of Hawaii at Mânoa, Honolulu, Hawaii 96822, USA.
authors.forename: Yoshitsugi
authors.initials: Y
authors.lastname: Hokama
authors.forename: Cara Empey
authors.initials: CE
authors.lastname: Campora
authors.forename: Cynthia
authors.initials: C
authors.lastname: Hara
authors.forename: Tina
authors.initials: T
authors.lastname: Kuribayashi
authors.forename: Diana
authors.initials: D
authors.lastname: Le Huynh
authors.forename: Kenichi
authors.initials: K
authors.lastname: Yabusaki
mesh_terms: D000328:Adult; D000368:Aged; D017153:Antibodies, Anticardiolipin / Q000097:blood*; D002308:Cardiolipins / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D015673:Fatigue Syndrome, Chronic / Q000276:immunology* / Q000473:pathology; D005260:Female; D006801:Humans; D007132:Immunoglobulin Isotypes / Q000276:immunology*; D007075:Immunoglobulin M / Q000276:immunology; D008297:Male; D008875:Middle Aged; D008930:Mitochondria, Liver / Q000276:immunology
chemical_list: D017153:Antibodies, Anticardiolipin; D002308:Cardiolipins; D007132:Immunoglobulin Isotypes; D007075:Immunoglobulin M