title: Use of triple antibiotic paste as a disinfectant for a traumatized immature tooth with a periapical lesion: a case report.
abstract: Elimination of microbial contamination from the root canal system is a precondition for successful root canal treatment. In this regard, mechanical instrumentation, irrigation, and intracanal medication are all important. This case report assesses the efficacy of a triple antibiotic paste consisting of metronidazole, ciprofloxacin, and minocycline in the disinfection of immature teeth with apical periodontitis. An 8-year-old girl presented at the Department of Pediatric Dentistry for the evaluation of right and left maxillary central incisors with crown fractures and luxation. The right central incisor had a large periapical lesion, which was treated by filling the canal with a ciprofloxacin/metronidazole/minocycline paste. After 4 months, the patient had no symptoms, and a radiograph showed the radiolucency had completely resolved. At the 1-year follow-up, a periapical radiograph showed complete root development and apical closure. These results indicate that triple antibiotic paste is effective in disinfecting immature teeth with periapical lesions.
authors.affiliation: Department of Pediatric Dentistry, Dental Sciences Centre, Gulhane Medical Academy, Ankara, Turkey.
authors.forename: Ozlem Marti
authors.initials: OM
authors.lastname: Akgun
authors.forename: Ceyhan
authors.initials: C
authors.lastname: Altun
authors.forename: Gunseli
authors.initials: G
authors.lastname: Guven
mesh_terms: D000891:Anti-Infective Agents, Local / Q000008:administration & dosage*; D002648:Child; D002939:Ciprofloxacin / Q000008:administration & dosage; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007180:Incisor / Q000293:injuries; D008795:Metronidazole / Q000008:administration & dosage; D008911:Minocycline / Q000008:administration & dosage; D010485:Periapical Periodontitis / Q000188:drug therapy* / Q000209:etiology; D012388:Root Canal Irrigants / Q000008:administration & dosage*; D019228:Tooth Crown / Q000293:injuries; D014082:Tooth Fractures / Q000150:complications* / Q000628:therapy; D014092:Tooth Root / Q000293:injuries*; D016896:Treatment Outcome
chemical_list: D000891:Anti-Infective Agents, Local; D004338:Drug Combinations; D012388:Root Canal Irrigants; D008795:Metronidazole; D002939:Ciprofloxacin; D008911:Minocycline