title: Statin use is associated with improved survival in patients with advanced heart failure receiving resynchronization therapy.
abstract: It is unknown whether statin use improves survival in patients with advanced chronic heart failure (HF) receiving cardiac resynchronization therapy (CRT). The authors retrospectively assessed the effect of statin use on survival in patients with advanced chronic HF receiving CRT alone (CRT-P) or CRT with implantable cardioverter-defibrillator therapy (CRT-D) in 1520 patients with advanced chronic HF from the Comparison of Medical Therapy, Pacing, and Defibrillation in Heart Failure (COMPANION) trial database. Six hundred three patients (40%) were taking statins at baseline. All-cause mortality was 18% in the statin group and 22% in the no statin group (hazard ratio [HR] 0.85; confidence interval (CI), 0.67-1.07; P=.15). In a multivariable analysis controlling for significant baseline characteristics and use of CRT-P/CRT-D, statin use was associated with a 23% relative risk reduction in mortality (HR, 0.77; CI, 0.61-0.97; P=.03). Statin use is associated with improved survival in patients with advanced chronic HF receiving CRT. No survival benefit was seen in patients receiving statins and optimal pharmacologic therapy without CRT.
authors.affiliation: Division of Cardiology, Lehigh Valley Health Network, Allentown, PA 18103, USA. andrew.sumner@lvh.com
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Sumner
authors.forename: John P
authors.initials: JP
authors.lastname: Boehmer
authors.forename: Leslie A
authors.initials: LA
authors.lastname: Saxon
authors.forename: Peter
authors.initials: P
authors.lastname: Carson
authors.forename: Arthur M
authors.initials: AM
authors.lastname: Feldman
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Galle
authors.forename: Michael R
authors.initials: MR
authors.lastname: Bristow
mesh_terms: D000368:Aged; D002304:Cardiac Pacing, Artificial; D002908:Chronic Disease; D003131:Combined Modality Therapy; D017147:Defibrillators, Implantable; D005260:Female; D006333:Heart Failure / Q000401:mortality / Q000628:therapy*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D008297:Male; D016016:Proportional Hazards Models; D012044:Regression Analysis; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome; D014481:United States / Q000453:epidemiology
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors