title: Systemic Inflammatory Response Syndrome and postoperative complications after orthognathic surgery.
abstract: Symptoms of Systemic Inflammatory Response Syndrome (SIRS) presenting immediately after surgery have lately been regarded as potential warnings of impending postoperative complications and multiple organ failure. Reports discussing the relationship between operative stress and SIRS are found in the field of digestive surgery, but not in that of oral surgery. Sixty-five patients with jaw deformity who had undergone maxillary and mandibular orthognathic surgery (Le Fort I osteotomy and sagittal splitting ramus osteotomy) between September 2003 and October 2006 were involved in this study. A search based on the SIRS diagnostic criteria resulted in assignment of 33 cases to the SIRS group and 32 cases to the non-SIRS group. Postoperative complications occurred in 27.3% of the SIRS group and 0.0% of the non-SIRS group (p<0.01). In four cases, a postoperative fluctuation in IL-6 level evaluated. These results suggest the importance of careful management of postoperative SIRS patients in preventing complications.
authors.affiliation: Division of Oral and Maxillofacial Surgery, Department of Clinical Oral Health Science, Suidobashi Hospital, Tokyo Dental College, Chiyoda-ku, Tokyo, Japan. kkasahara@tdc.ac.jp
authors.forename: Kiyohiro
authors.initials: K
authors.lastname: Kasahara
authors.forename: Yasutomo
authors.initials: Y
authors.lastname: Yajima
authors.forename: Chihaya
authors.initials: C
authors.lastname: Ikeda
authors.forename: Isao
authors.initials: I
authors.lastname: Kamiyama
authors.forename: Takashi
authors.initials: T
authors.lastname: Takaki
authors.forename: Takashi
authors.initials: T
authors.lastname: Kakizawa
authors.forename: Takahiko
authors.initials: T
authors.lastname: Shibahara
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D016063:Blood Loss, Surgical; D001831:Body Temperature / Q000502:physiology; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006560:Herpes Labialis / Q000209:etiology; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D007571:Jaw Diseases / Q000601:surgery*; D007958:Leukocyte Count; D008297:Male; D008310:Malocclusion / Q000601:surgery*; D008334:Mandible / Q000601:surgery; D008437:Maxilla / Q000601:surgery; D008875:Middle Aged; D010027:Osteotomy / Q000009:adverse effects* / Q000379:methods; D019340:Osteotomy, Le Fort / Q000009:adverse effects; D011183:Postoperative Complications; D012119:Respiration; D013530:Surgical Wound Infection / Q000209:etiology; D018746:Systemic Inflammatory Response Syndrome / Q000209:etiology*; D013997:Time Factors; D055815:Young Adult
chemical_list: D015850:Interleukin-6