Receptors for acylethanolamides-GPR55 and GPR119.
Acylethanolamides are lipid substances widely distributed in the body, generated from a membrane phospholipid precursor, N-acylphosphatidylethanolamine (NAPE). The recent identification of arachidonoyl ethanolamide (anandamide or AEA) as an endogenous cannabinoid ligand has focused attention on acylethanolamides, which has further increased with the subsequent identification of related additional acylethanolamides with signaling function, such as oleoylethanolamide (OEA) and palmitoylethanolamide (PEA). Most of the biological functions of anandamide are mediated by the two G protein-coupled cannabinoid receptors identified to date, CB(1) and CB(2), with the transient receptor potential vanilloid-1 receptor being an additional potential target. There has been increasing pharmacological evidence for the existence of additional cannabinoid receptors, with the orphan G protein-coupled receptor GPR55 being the most actively scrutinized, and is one of the subjects of this review. The other receptor reviewed here is GPR119, which can recognize OEA and PEA. These two acylethanolamides, although structurally related to anandamide, do not interact with classical cannabinoid receptors. Instead, they have high affinity for the nuclear receptor PPARalpha, which is believed to mediate many of their biological effects.
Godlewski
Grzegorz
G
Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA. godlewskig@mail.nih.gov
Offertáler
László
L
Wagner
Jens A
JA
Kunos
George
G
D000577:Amides / Q000378:metabolism*; D000818:Animals; D063385:Cannabinoid Receptor Modulators / Q000378:metabolism; D002186:Cannabinoids / Q000378:metabolism; D004727:Endothelium / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism*; D008024:Ligands; D008246:Lysophospholipids / Q000378:metabolism; D009928:Organ Specificity; D043882:Receptors, Cannabinoid; D043562:Receptors, G-Protein-Coupled / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction
D000577:Amides; D063385:Cannabinoid Receptor Modulators; D002186:Cannabinoids; D005227:Fatty Acids; C519854:GPR119 protein, human; C524885:GPR55 protein, human; D008024:Ligands; D008246:Lysophospholipids; D043882:Receptors, Cannabinoid; D043562:Receptors, G-Protein-Coupled