[Effects of Ginkgo biloba extract (EGB) on acute myocardial ischemia induced by isoproterenol in rats].
OBJECTIVE
To investigate the therapeutic effects of Ginkgo biloba extract (EGb) in rats with acute myocardial injury induced by isoproterenol (ISO).


METHODS
The rats, induced by Isoproterenol (4 mg x kg(-1) x d(-1), 10 d, sc), were divided into groups: sham, model, metoprolol (10 mg x kg(-1) x d(-1), 13 d, ig), EGb (100 mg x kg(-1) x d(-1), 13 d, ig).


RESULTS
The cardiac parameters of the Model group were compromised significantly in both systolic and diastolic function. Improvement in cardiac function by EGb was significant. In model groups, plasma activities of AST, LDH, CK, HBDH, CKMB and ventricular weight index (LV and RV/BW) were elevated significantly. With the treatment with EGb and metoprolol, the enzymes and ventricular weight index were significantly ameliorated.


CONCLUSIONS
G. biloba extract was beneficial to cardiac performance by improving myocardium enzymes and cardiac function in isoproterenol induced myocardial injury in rats.
Ding
Fuyun
F
Nanjing Normal University, Nanjing 210046, China. dingfuyun123@163.com
Wang
Yongqing
Y
Liu
Yun
Y
Yao
Weifeng
W
Yu
Shuqin
S
Xu
Guanglin
G
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D020441:Ginkgo biloba / Q000737:chemistry*; D006439:Hemodynamics / Q000187:drug effects; D007545:Isoproterenol / Q000009:adverse effects*; D008297:Male; D017202:Myocardial Ischemia / Q000139:chemically induced* / Q000188:drug therapy* / Q000201:enzymology / Q000503:physiopathology; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley
D004365:Drugs, Chinese Herbal; D007545:Isoproterenol