title: Evolution of amino-terminal pro-B type natriuretic peptide testing in heart failure.
abstract: The use of natriuretic peptide testing has expanded considerably over the recent years. Thanks to clinical trials that have demonstrated significant benefits associated with testing for B-type natriuretic peptide (BNP) and its amino-terminal pro-peptide (NTproBNP), testing for these peptides is now ubiquitous in modern medicine. This review will focus on the use of NTproBNP in clinical medicine, with a discussion of the biologic significance of NT-proBNP, its proven present uses and potential future applications.
authors.affiliation: Cardiology Division, Massachusetts General Hospital, 55 Fruit Street, Yawkey 5984, Boston, Massachusetts 02114, USA. JJanuzzi@partners.org
authors.forename: James L
authors.initials: JL
authors.lastname: Januzzi
authors.forename: Antoni
authors.initials: A
authors.lastname: Bayes-Genis
mesh_terms: D015415:Biomarkers / Q000097:blood; D002317:Cardiovascular Agents / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D006333:Heart Failure / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D011379:Prognosis
chemical_list: D015415:Biomarkers; D002317:Cardiovascular Agents; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain