A truncated erythropoietin receptor EPOR-T is associated with hypertension susceptibility.
Erythropoietin (EPO) and its analogs increase blood pressure (BP) in susceptible patients. The ratio of truncated to full EPO receptors (EPORs) in endothelial progenitor cells harvested from anemic patients receiving EPO while undergoing hemodialysis is related to the increased BP observed in these patients. Truncated EPORs exert a hypertensive effect by opposing full EPOR stimulation that augments cyclic guanosine monophosphate (GMP) in vascular endothelium. The contribution of this discovery to clinical practice is debatable.
Carruthers
S G
SG
Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates. carruthg@hotmail.com
D000740:Anemia / Q000188:drug therapy / Q000209:etiology; D006152:Cyclic GMP / Q000378:metabolism; D004198:Disease Susceptibility; D042783:Endothelial Cells / Q000378:metabolism*; D006397:Hematinics / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D006973:Hypertension / Q000139:chemically induced* / Q000378:metabolism*; D015999:Multivariate Analysis; D012333:RNA, Messenger / Q000378:metabolism; D017467:Receptors, Erythropoietin / Q000235:genetics / Q000378:metabolism*; D006435:Renal Dialysis / Q000009:adverse effects; D013234:Stem Cells / Q000378:metabolism*
D006397:Hematinics; D012333:RNA, Messenger; D017467:Receptors, Erythropoietin; D006152:Cyclic GMP