title: A high-performance nanobio photocatalyst for targeted brain cancer therapy.
abstract: We report pronounced and specific antiglioblastoma cell phototoxicity of 5 nm TiO(2) particles covalently tethered to an antibody via a dihydroxybenzene bivalent linker. The linker application enables absorption of a visible part of the solar spectrum by the nanobio hybrid. The phototoxicity is mediated by reactive oxygen species (ROS) that initiate programmed death of the cancer cell. Synchrotron X-ray fluorescence microscopy (XFM) was applied for direct visualization of the nanobioconjugate distribution through a single brain cancer cell at the submicrometer scale.
authors.affiliation: The Center for Nanoscale Materials, Argonne National Laboratory, Argonne, Illinois 60439, USA. rozhkova@anl.gov
authors.forename: Elena A
authors.initials: EA
authors.lastname: Rozhkova
authors.forename: Ilya
authors.initials: I
authors.lastname: Ulasov
authors.forename: Barry
authors.initials: B
authors.lastname: Lai
authors.forename: Nada M
authors.initials: NM
authors.lastname: Dimitrijevic
authors.forename: Maciej S
authors.initials: MS
authors.lastname: Lesniak
authors.forename: Tijana
authors.initials: T
authors.lastname: Rajh
mesh_terms: D000911:Antibodies, Monoclonal / Q000494:pharmacology* / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000188:drug therapy*; D002384:Catalysis; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D006873:Hydroquinones / Q000737:chemistry / Q000494:pharmacology*; D008422:Materials Testing; D008954:Models, Biological; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology; D010316:Particle Size; D010777:Photochemistry; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000911:Antibodies, Monoclonal; D006873:Hydroquinones; C009495:titanium dioxide; D014025:Titanium