title: Evaluation of the agreement between clinical and laboratorial exams in the diagnosis of leprosy.
abstract: This study examined the correlation between the clinical and laboratory diagnosis of leprosy, using biopsy results from laboratories 'A' and 'B' and the ML Flow test. Clinical and histopathological diagnoses presented 67.6% agreement. The laboratories showed 73.7% agreement in the bacterial index and laboratory 'B' detected 25.4% more positives. The highest agreement was in the LL form and lowest, in the I form. The highest diagnostic discrepancy was for the BB form. Clinical diagnosis agreement was 41.3% for laboratory 'A' and 54% for 'B'. The ML Flow test reclassified 10.7% of the patients. The spectrum of leprosy classification is important for a clearer understanding of the disease and its proper treatment, but is not used in health services, which use the simplified WHO criteria. This could be complemented by ML Flow testing. Such simplification is unacceptable for Leprosy Reference Centers regarding patient attendance, teaching and research, for which the standardization of the Ridley-Jopling classification is recommended.
authors.affiliation: National Reference Center for Sanitary Dermatology and Leprosy, Clinical Hospital, Faculty of Medicine, Federal University of Uberlândia, MG, Brazil.
authors.forename: André Costa
authors.initials: AC
authors.lastname: Teixeira
authors.forename: Danilo Lemos
authors.initials: DL
authors.lastname: Cruvinel
authors.forename: Fábio Rodrigues de
authors.initials: FR
authors.lastname: Roma
authors.forename: Leandro Ferreira
authors.initials: LF
authors.lastname: Luppino
authors.forename: Luís Henrique Pereira
authors.initials: LH
authors.lastname: Resende
authors.forename: Theo de
authors.initials: Td
authors.lastname: Sousa
authors.forename: Samira
authors.initials: S
authors.lastname: Bührer-Sékula
authors.forename: Isabela Maria Bernardes
authors.initials: IM
authors.lastname: Goulart
mesh_terms: D000907:Antibodies, Bacterial / Q000097:blood*; D000942:Antigens, Bacterial; D001706:Biopsy; D006017:Glycolipids; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D007918:Leprosy / Q000145:classification / Q000175:diagnosis* / Q000473:pathology; D009166:Mycobacterium leprae / Q000276:immunology*; D012867:Skin / Q000382:microbiology / Q000473:pathology*
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D006017:Glycolipids; D007075:Immunoglobulin M; C045169:phenolic glycolipid I, Mycobacterium leprae