title: Role of Wnt inhibitory factor-1 and Wnt/wingless signaling in choroid plexus tumors.
abstract: Little is known on pathways involved in the pathogenesis of choroid plexus tumors (CPTs). The finding of overexpression of Wnt inhibitory factor-1 (Wif-1) prompted us to investigate the functional role of Wif-1 as well as nuclear accumulation of beta-catenin in CPT. In Z310 neoplastic choroid plexus epithelial cells, silencing of Wif1 expression increased proliferative activity not associated with increased canonical Wnt signaling. Nuclear beta-catenin accumulation was also lacking in a series of 16 CPT. In conclusion, our data show that Wif-1 inhibits proliferation of neoplastic choroid plexus epithelial cells, but argue against a role of canonical Wnt/wingless signaling in CPT.
authors.affiliation: Institute of Neuropathology, University Hospital Münster, Münster, Germany.
authors.forename: Manuel
authors.initials: M
authors.lastname: Tomm
authors.forename: Arend
authors.initials: A
authors.lastname: Koch
authors.forename: Sonja
authors.initials: S
authors.lastname: Mertsch
authors.forename: Brigitte
authors.initials: B
authors.lastname: Wrede
authors.forename: Astrid
authors.initials: A
authors.lastname: Jeibmann
authors.forename: Johannes
authors.initials: J
authors.lastname: Wolff
authors.forename: Werner
authors.initials: W
authors.lastname: Paulus
authors.forename: Martin
authors.initials: M
authors.lastname: Hasselblatt
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000502:physiology*; D000818:Animals; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D016545:Choroid Plexus Neoplasms / Q000473:pathology*; D004847:Epithelial Cells / Q000473:pathology; D051381:Rats; D012097:Repressor Proteins / Q000502:physiology*; D015398:Signal Transduction; D051153:Wnt Proteins / Q000502:physiology*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D012097:Repressor Proteins; C485569:WIF1 protein, human; D051153:Wnt Proteins