title: Resolution-recovery for EPR imaging of free radical molecules in mice.
abstract: A method of post-processing to enhance the image resolution of the distribution of free radical molecules obtained with continuous-wave electron paramagnetic resonance (CW-EPR) imaging is reported. The low spatial resolution of EPR imaging, which has created difficulties in biomedical applications, was overcome by the method of resolution-recovery for EPR imaging. High spatial resolution images for the distribution of free radical molecules with a very short relaxation time were obtained with this method. The method's two-step postprocessing consists of conventional deconvolution and filtered back-projection and a process of iterative deconvolution. The resolution-recovery method was demonstrated with three-dimensional (3D) imaging of stable nitroxyl radicals in mouse head. In phantom experiments with a solution of triarylmethyl (TAM) radicals, the spatial resolution was improved by a factor of 7 with the resolution-recovery method.
authors.affiliation: Department of Electrical Engineering, Yamagata University, Yonezawa, Yamagata, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Ikebata
authors.forename: Hideo
authors.initials: H
authors.lastname: Sato-Akaba
authors.forename: Takashi
authors.initials: T
authors.lastname: Aoyama
authors.forename: Hirotada
authors.initials: H
authors.lastname: Fujii
authors.forename: Kouichi
authors.initials: K
authors.lastname: Itoh
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hirata
mesh_terms: D000465:Algorithms; D000818:Animals; D004578:Electron Spin Resonance Spectroscopy / Q000379:methods*; D005609:Free Radicals / Q000032:analysis*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D014018:Tissue Distribution; D051598:Whole Body Imaging / Q000379:methods*
chemical_list: D005609:Free Radicals