Inflammatory BCG adenitis associated with immune reconstitution following allogeneic haematopoietic stem cell transplant in infancy.
We describe four cases of a localized, granulomatous reaction to BCG including ipsilateral painful, suppurative lymphadenopathy associated with donor immune reconstitution following allogeneic haematopoietic stem cell transplant performed in infancy and preceded by uneventful, routine BCG immunisation. The management of the inflammatory disease in these cases with surgery, antimycobacterial chemotherapy and steroids, is discussed.
Searle
E
E
Department of Blood and Marrow Transplant, Royal Manchester Children's Hospital, Manchester, UK.
Patel
H
H
Vilar
F J
FJ
Gharib
M
M
Turner
A J
AJ
Batra
G
G
Wynn
R F
RF
D001500:BCG Vaccine / Q000627:therapeutic use*; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007249:Inflammation / Q000276:immunology*; D008199:Lymphadenitis / Q000276:immunology* / Q000628:therapy*; D008297:Male; D014184:Transplantation, Homologous
D001500:BCG Vaccine