title: Chiral Brønsted acid-catalyzed asymmetric Friedel-Crafts alkylation of pyrroles with nitroolefins.
abstract: A highly efficient Friedel-Crafts reaction of pyrroles with nitroolefins by a chiral phosphoric acid was realized. With 5 mol % of catalyst, reactions conducted at rt afforded the 2-substituted or 2,5-disubstituted pyrroles in up to 94% ee for a wide range of substrates.
authors.affiliation: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China.
authors.forename: Yi-Fei
authors.initials: YF
authors.lastname: Sheng
authors.forename: Qing
authors.initials: Q
authors.lastname: Gu
authors.forename: An-Jiang
authors.initials: AJ
authors.lastname: Zhang
authors.forename: Shu-Li
authors.initials: SL
authors.lastname: You