Navigating the deubiquitinating proteome with a CompPASS.
Deubiquitinating enzymes (DUBs) act on ubiquitinated substrates to regulate their modification and stability. In this issue, Sowa et al. (2009) present a comprehensive proteomic analysis of DUB interacting proteins in humans and a new quantitative scoring system for hits (CompPASS), providing a resource that links DUBs to biological pathways.
Jackson
Peter K
PK
Department of Cell Regulation, Genentech Inc., South San Francisco, CA 94080, USA. pjackson@gene.com
D010450:Endopeptidases / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D020543:Proteome; D012984:Software; D025801:Ubiquitin / Q000378:metabolism
D020543:Proteome; D025801:Ubiquitin; D010450:Endopeptidases