Structural studies on aryl-substituted enaminoketones and their thio analogues. Part II. Experimental and DFT calculated carbon-carbon coupling constants, (n)J(CC)'s (n = 1-3).
Spin-spin carbon-carbon coupling constants across one, two and three bonds, J(CC), have been measured for a series of aryl-substituted Z-s-Z-s-E enaminoketones and their thio analogues. As a result, a large set, altogether 178, of J(CC)s has been obtained. It consists of 82 couplings across one bond, 31 couplings across two bonds and 65 couplings across three bonds. Independently, the DFT calculations at the B3PW91/6-311++G(d,p)//B3PW91/6-311++G(d,p) level yielded a set of theoretical J(CC) values. A comparison of these two sets of data gave an excellent linear correlation with parameters a and b close to ideal; a = 0.9978 which is not far from unity and b = 0.22 Hz which is close to zero. The (1)J(CC) couplings determined for the crucial fragment of the molecules, i.e. -C=C-C=O (or -C=C-C=S), are: (1)J(C=C) approximately 68 Hz (67 Hz) and (1)J(C-C) = 60.5 Hz (60.0 Hz). The corresponding couplings found for the Z-s-Z-s-E isomer of the parent enaminoketone, 4-methylamino-but-3-en-2-one are 64.1 and 59.3 Hz, respectively. The most sensitive towards substitution of the oxygen atom by sulfur are two-bond couplings between the alpha-vinylic and aromatic C(ipso) carbon atoms, which attain 12 Hz in the enaminoketone derivatives and decrease to 5 Hz in their thio analogues.
Bugaj
Marta
M
Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland.
Baran
Piotr A
PA
Kamieńska-Trela
Krystyna
K
Krówczyński
Adam
A
D002244:Carbon / Q000737:chemistry*; D002247:Carbon Isotopes; D003198:Computer Simulation; D007659:Ketones / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods / Q000592:standards*; D008956:Models, Chemical; D015394:Molecular Structure; D012015:Reference Standards; D013237:Stereoisomerism; D013438:Sulfhydryl Compounds / Q000737:chemistry*
D002247:Carbon Isotopes; D007659:Ketones; D013438:Sulfhydryl Compounds; D002244:Carbon