[Research progress in estimating parameters of blood substitute function].
The shortage of healthy blood resource and the problem of virus infection have urged the study of blood substitute. The technologies of modified hemoglobin, perfluorocarbons and Hb-vesicles have been developing quickly, and some of which have already been formed into large-scale preparation and production. However, there is no completed evaluation system for the blood substitute at present, and it is still hard to estimate the function of blood substitute completely. This article takes the evaluation of the blood substitute as a key point, discusses the evaluation parameters of blood substitute, and presents the physical and chemical property, the availability and safety as well as the preservation condition of the blood substitute. The data concerned are based on the studies in China and abroad and referred to the latest progress all over the world.
Xie
Jiaxin
J
College of Bioengineering, Chongqing University, Chongqing 400030, China.
Wang
Xiang
X
D000818:Animals; D001802:Blood Substitutes / Q000008:administration & dosage* / Q000592:standards*; D055598:Chemical Phenomena; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism; D005466:Fluorocarbons / Q000008:administration & dosage* / Q000009:adverse effects; D006454:Hemoglobins / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D011786:Quality Control
D001802:Blood Substitutes; D005466:Fluorocarbons; D006454:Hemoglobins