title: Aliphatic polyester terpolymers for stent coating and drug elution: effect of polymer composition on drug solubility and release.
abstract: Ring-opening terpolymerization of L-lactide (LA), -caprolactone (CL), and glycolide (GA) was performed in the presence of tin (II) 2-ethylhexanoate at 170 degrees C. Random terpolyesters with weight-average molecular weight up to 130,000 g/mol were obtained. These terpolyesters, especially those with LA:CL:GA composition of 3:1:1, provided good coating integrity following spraying onto bare metal stents. The semi-synthetic macrolide immunosuppressant, everolimus, was incorporated into the terpolyester coating, and its release from the stent was evaluated. Unlike PLLA homopolymers, which are immiscible with the drug and non-optimal for controlled release, these terpolymers gave excellent control in a screening study, by tuning terpolymer molecular weight, relative monomer ratio, and drug-to-polymer ratio. Adjusting the polymer properties to improve drug solubility (or miscibility) in the polymer coating was found beneficial to the release profile.
authors.affiliation: University of Massachusetts, Amherst, MA 01003, USA.
authors.forename: Delphine
authors.initials: D
authors.lastname: Chan-Seng
authors.forename: T
authors.initials: T
authors.lastname: Ranganathan
authors.forename: Xiongfei
authors.initials: X
authors.lastname: Zhang
authors.forename: Yiwen
authors.initials: Y
authors.lastname: Tang
authors.forename: Qing
authors.initials: Q
authors.lastname: Lin
authors.forename: Lothar
authors.initials: L
authors.lastname: Kleiner
authors.forename: Todd
authors.initials: T
authors.lastname: Emrick
mesh_terms: D016503:Drug Delivery Systems / Q000379:methods; D054855:Drug-Eluting Stents; D011091:Polyesters / Q000737:chemistry* / Q000493:pharmacokinetics*; D011108:Polymers / Q000737:chemistry* / Q000493:pharmacokinetics*; D012995:Solubility
chemical_list: D011091:Polyesters; D011108:Polymers