Stressing out over tRNA cleavage.
A conserved response to stress involves endonucleolytic cleavage of cytoplasmic transfer RNAs (tRNAs) by ribonucleases that are normally secreted or sequestered. Ribonuclease activation or release is an intriguing new aspect of cellular stress responses, with a potential impact on translation, apoptosis, cancer, and disease progression.
Thompson
Debrah M
DM
Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, University of Arizona, Tucson, AZ 85721, USA.
Parker
Roy
R
D000818:Animals; D018407:Bacterial Physiological Phenomena; D002468:Cell Physiological Phenomena; D002477:Cells / Q000201:enzymology; D006801:Humans; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000378:metabolism; D012343:RNA, Transfer / Q000378:metabolism*; D012260:Ribonucleases / Q000378:metabolism; D013312:Stress, Physiological; D015003:Yeasts / Q000201:enzymology / Q000502:physiology
D012333:RNA, Messenger; D012343:RNA, Transfer; D012260:Ribonucleases