Manipulation of T(H)17 responses in pulmonary immunity and disease through vaccination.
Since the discovery of a novel subset of CD4(+) T helper cells, T(H)17 cells have been implicated in a wide range of human diseases, including autoimmunity, allergic reactions and autoinflammatory diseases. Conversely, it has also been determined that T(H)17 cells are required to mount a protective immune response to a number of pathogens. It has therefore been of great interest to manipulate T(H)17 responses to either prevent disease or promote immunity. Vaccination is a particularly attractive approach for this manipulation. With a focus on the pulmonary mucosal environment, we herein review T(H)17 responses and potential methods for manipulation.
Sonnenberg
Gregory F
GF
Department of Pathobiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
Weiner
David B
DB
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology; D002454:Cell Differentiation; D005786:Gene Expression Regulation; D054884:Host-Pathogen Interactions / Q000276:immunology; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology; D020381:Interleukin-17 / Q000096:biosynthesis / Q000276:immunology*; D008171:Lung Diseases / Q000276:immunology* / Q000517:prevention & control*; D051379:Mice; D011014:Pneumonia / Q000276:immunology; D020545:Respiratory Mucosa / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology* / Q000378:metabolism; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology* / Q000378:metabolism; D014611:Vaccination; D019444:Vaccines, DNA / Q000276:immunology
D020381:Interleukin-17; D019444:Vaccines, DNA