title: Recognition of DNase I hypersensitive sites in multiple cell lines.
abstract: DNase I hypersensitive sites (DHSs) associate with a wide variety of functional genomic elements. Successful prediction of DHSs in computational models would dramatically accelerate the annotation of the human genome. In this study, a method of Increment of Diversity with Quadratic Discriminant analysis (IDQD) is presented for DHSs prediction in K562, CD4+ T, Hela and GM06990 cell lines. The average accuracies of 10-fold cross-validation test are 98.52%, 96.50%, 99.25% and 97.58%, respectively, and the mean areas under ROC curves (auROC) are all greater than 0.90. The prediction results indicate that the IDQD method is an effective tool for DHSs recognition.
authors.affiliation: Laboratory of Theoretical Biophysics, School of Physical Science and Technology, Inner Mongolia University, Hohhot 010021, China. chenwei_imu@yahoo.com.cn
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.forename: Liaofu
authors.initials: L
authors.lastname: Luo
authors.forename: Lirong
authors.initials: L
authors.lastname: Zhang
authors.forename: Hao
authors.initials: H
authors.lastname: Lin
mesh_terms: D002478:Cells, Cultured; D003850:Deoxyribonuclease I / Q000737:chemistry*; D015894:Genome, Human; D006367:HeLa Cells; D006801:Humans; D008962:Models, Theoretical
chemical_list: D003850:Deoxyribonuclease I