Letrozole as a booster therapy in growth hormone deficiency.
A 13 year old boy presented to us with short stature. Evaluation revealed growth hormone (GH) deficiency. He was treated with GH replacement for 10 months and to further boost up the growth potential, an aromatase inhibitor Letrozole was added to GH therapy. After one year of combination therapy, patient had significant improvement in predicted adult height without a negative impact on pubertal progression.
Kumar
K V S Hari
KV
Department of Endocrinology, Medwin Hospitals, Nampally, Hyderabad 500 001, AP, India. hariendo@rediffmail.com
Jayaraman
Muthukrishnan
M
Verma
Abhyuday
A
Modi
Kirtikumar D
KD
D000293:Adolescent; D047072:Aromatase Inhibitors / Q000627:therapeutic use*; D006130:Growth Disorders / Q000188:drug therapy*; D013006:Growth Hormone / Q000172:deficiency*; D006801:Humans; D000077289:Letrozole; D008297:Male; D009570:Nitriles / Q000627:therapeutic use*; D014230:Triazoles / Q000627:therapeutic use*
D047072:Aromatase Inhibitors; D009570:Nitriles; D014230:Triazoles; D000077289:Letrozole; D013006:Growth Hormone