title: Xanthoradones, new potentiators of imipenem activity against methicillin-resistant Staphylococcus aureus, produced by Penicillium radicum FKI-3765-2: I. Taxonomy, fermentation, isolation and biological properties.
abstract: The fungal strain FKI-3765-2, identified as Penicillium radicum, was found to produce potentiators of imipenem activity against methicillin-resistant Staphylococcus aureus (MRSA). Two new compounds, designated xanthoradones A and B, were isolated from the fermentation broth of the producing strain by solvent extraction, octadecyl silyl column chromatography and preparative HPLC. Xanthoradones A and B potentiated imipenem activity against MRSA by decreasing the MIC value of imipenem from 16 microg ml(-1) to 0.060 and 0.030 microg ml(-1), respectively.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Kitasato University, Minato-ku, Tokyo, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Yamazaki
authors.forename: Kenichi
authors.initials: K
authors.lastname: Nonaka
authors.forename: Rokuro
authors.initials: R
authors.lastname: Masuma
authors.forename: Satoshi
authors.initials: S
authors.lastname: Omura
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tomoda
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects; D045744:Cell Line, Tumor; D004396:Coloring Agents; D004357:Drug Synergism; D005285:Fermentation; D006801:Humans; D015378:Imipenem / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D012275:Oryza / Q000382:microbiology; D010407:Penicillium / Q000737:chemistry / Q000145:classification / Q000378:metabolism*; D013778:Tetrazolium Salts; D013844:Thiazoles
chemical_list: D000900:Anti-Bacterial Agents; D004396:Coloring Agents; D013778:Tetrazolium Salts; D013844:Thiazoles; C544254:xanthoradone A; C544255:xanthoradone B; D015378:Imipenem; C022616:thiazolyl blue