title: The effect of preoperative chemoradiotherapy on lymph node harvest after total mesorectal excision for rectal cancer.
abstract: OBJECTIVE
  This study was designed to evaluate whether preoperative chemoradiotherapy reduces the number of lymph nodes harvested after total mesorectal excision of rectal cancer.
  
  
  METHODS
  From January 1995 to December 2007, 168 consecutive patients with rectal cancer underwent total mesorectal excision in the Department of Surgical Oncology at the University of Crete. The patients were divided into three groups (Group A, no chemoradiotherapy; Group B, short course of chemoradiotherapy; Group C, long course of chemoradiotherapy). The primary end points were the number of lymph nodes examined and the percentage of patients with fewer than 12 lymph nodes removed.
  
  
  RESULTS
  The overall number of lymph nodes retrieved was not significantly reduced by the use of preoperative chemoradiotherapy. The percentage of patients with fewer than 12 lymph nodes examined, however, was significantly higher in Group C. The leakage rate and the duration of hospital stay were not affected. The rate of wound infections was higher in Group C.
  
  
  CONCLUSIONS
  Preoperative chemoradiotherapy did not significantly decrease the overall number of lymph nodes retrieved but did increase the percentage of patients with fewer than 12 lymph nodes examined.
authors.affiliation: Department of Surgical Oncology, University Hospital of Crete, Crete, Greece. taflampas2003@yahoo.gr
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Taflampas
authors.forename: Manousos
authors.initials: M
authors.lastname: Christodoulakis
authors.forename: Sofia
authors.initials: S
authors.lastname: Gourtsoyianni
authors.forename: Katerina
authors.initials: K
authors.lastname: Leventi
authors.forename: John
authors.initials: J
authors.lastname: Melissas
authors.forename: Dimitrios D
authors.initials: DD
authors.lastname: Tsiftsis
mesh_terms: D000230:Adenocarcinoma / Q000556:secondary / Q000628:therapy*; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D003082:Colectomy / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008197:Lymph Node Excision / Q000379:methods; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D009367:Neoplasm Staging / Q000379:methods; D011300:Preoperative Care / Q000379:methods*; D011379:Prognosis; D018714:Radiotherapy, Adjuvant; D012004:Rectal Neoplasms / Q000473:pathology / Q000628:therapy*; D012189:Retrospective Studies; D020858:Tissue and Organ Harvesting / Q000379:methods*
chemical_list: D000970:Antineoplastic Agents