[Use of antioxidants in prevention of the cardiovascular disease: meta-analysis of clinical trials].
OBJECTIVE
to evaluate if used of medication with antioxidants, antiplatelets, statins and modulators of inflammation reduces effectively the risk of presenting a cardiovascular disease (CVD).


METHODS
a search on clinical trials (randomized, double blind and controlled clinical studies) in which the use of antioxidants, antiplatelets, statins and modulators of inflammation were investigated for the primary and secondary prevention of CVD. The selected studies were analyzed by a systematic revision, applying the meta-analysis.


RESULTS
20 studies were included. In the subgroup of vitamin E 3623 events of the non fatal acute myocardial infarction (AMI) appeared, RR = 1 (0.93-1.06) IC 95 %, p = 0.01. In the subgroup of statins 2795 events of non fatal acute myocardial infarction (AMI) appeared, RR = 0.68 (0.63-0.73) IC 95 %, p = 0.02. In the subgroup of antiplatelets 1199 events of non fatal AMI appeared, RR = 0. 91 (0.81-1.02) IC 95 %, p = 0.42. In the subgroup of omega-3 fatty acids 434 events of the non fatal AMI appeared, RR = 0.93 (0.76-1.13) IC 95 %, p = 0.002.


CONCLUSIONS
vitamin E did not show any benefit, in comparison with the antiplatelets, statins, and omega-3 fatty acids.
García-Alvarez
José Luis
JL
Hospital General de Zona 24, Instituto Mexicano del Seguro Social, Distrito Federal, México. jlgarciav@salud.gob.mx
Sánchez-Tovar
Marisol
M
García-Vigil
José Luis
JL
D000975:Antioxidants / Q000627:therapeutic use*; D002318:Cardiovascular Diseases / Q000517:prevention & control*; D006801:Humans; D016032:Randomized Controlled Trials as Topic
D000975:Antioxidants