title: [CD4-positive diffuse large B-cell lymphoma].
abstract: An 82-year-old man received right upper lobectomy for lung cancer in April 2006. In August, 2006, he was readmitted to our hospital due to left cervical and left inguinal lymph node swelling. A pathologic diagnosis of diffuse large B-cell lymphoma (DLBCL) was made from a biopsy specimen of the left cervical lymph node. The immunophenotype of the lymphoma cells was CD2-, sCD3-, cCD3-, CD4+, CD5+, CD7-, CD8-, CD10-, CD19+, CD20+, CD23+, CD25+, kappa+, lambda-, CD56-, and dual staining confirmed that the cells were positive for both CD4 and CD19. From these findings, he was diagnosed with CD4-positive DLBCL. Five cycles of R-CHOP were performed and complete remission was achieved. To our knowledge, this is the first report of CD4-positive DLBCL.
authors.affiliation: Department of Hematology/Oncology, Yokohama Municipal Citizen's Hospital.
authors.forename: Tomonori
authors.initials: T
authors.lastname: Nakazato
authors.forename: Kazuhito
authors.initials: K
authors.lastname: Suzuki
authors.forename: Ai
authors.initials: A
authors.lastname: Mihara
authors.forename: Yukinari
authors.initials: Y
authors.lastname: Sanada
authors.forename: Tsunayuki
authors.initials: T
authors.lastname: Kakimoto
authors.forename: Sachiko
authors.initials: S
authors.lastname: Yoshida
mesh_terms: D000369:Aged, 80 and over; D000911:Antibodies, Monoclonal / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D015704:CD4 Antigens / Q000032:analysis*; D004317:Doxorubicin / Q000008:administration & dosage; D006801:Humans; D008175:Lung Neoplasms / Q000601:surgery; D008198:Lymph Nodes / Q000473:pathology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis* / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D009333:Neck; D011013:Pneumonectomy; D011239:Prednisolone / Q000008:administration & dosage; D012074:Remission Induction; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D000911:Antibodies, Monoclonal; D015704:CD4 Antigens; D014750:Vincristine; D004317:Doxorubicin; D011239:Prednisolone