Neurophysiological and functional MRI evidence of reorganization of cortical motor areas in cerebral arteriovenous malformation.
Functional magnetic resonance imaging (fMRI) research has shown that brain arteriovenous malformations (AVMs) lead to reorganization of cortical motor areas. Since it is known that blood oxygenation level-dependent signal in fMRI may be influenced by the hemodynamic perturbation associated with the presence of the AVM, in the present study, a combined exploration with fMRI and transcranial magnetic stimulation was performed in a patient with a right rolandic AVM in order to explore the relationship between neuronal and hemodynamic activity. The combined protocol of investigation adopted in this study was able to provide significant information regarding neuronal activity of the different cortical areas that partake to post-lesional reorganization.
Caramia
Francesca
F
Department of Neurological Sciences, University of Rome La Sapienza, Rome, Italy. francesca.caramia@uniroma1.it
Francia
Ada
A
Mainero
Caterina
C
Tinelli
Emanuele
E
Palmieri
Maria Giuseppina
MG
Colonnese
Claudio
C
Bozzao
Luigi
L
Caramia
Maria Donatella
MD
D000328:Adult; D001921:Brain / Q000502:physiology; D002533:Cerebral Angiography / Q000379:methods; D002540:Cerebral Cortex / Q000473:pathology / Q000503:physiopathology*; D005260:Female; D006439:Hemodynamics; D006801:Humans; D002538:Intracranial Arteriovenous Malformations / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008959:Models, Neurological; D009474:Neurons / Q000378:metabolism / Q000502:physiology; D009482:Neurophysiology; D010292:Paresthesia / Q000503:physiopathology; D050781:Transcranial Magnetic Stimulation