Maternal and fetal variants in the TGF-beta3 gene and risk of pregnancy-induced hypertension in a predominantly Latino population.
OBJECTIVE
We sought to determine whether polymorphisms in the transforming growth factor (TGF)-beta3 gene are associated with risk of pregnancy-induced hypertension (PIH) in case-control mother-baby dyads.


METHODS
Patients (n = 136) and control subjects (n = 169) were recruited from our hospital. We genotyped 4 TGF-beta3 polymorphisms and examined association with PIH using logistic regression, adjusting for parity, maternal age, gestational age at delivery, fetal (or maternal) genotypes for the polymorphism in question, and the 3 other polymorphisms within the TGF-beta3 gene.


RESULTS
Only 1 of the TGF-beta3 polymorphisms (rs11466414) was associated with PIH. Mothers who carried a baby with a minor allele were at decreased risk (odds ratio(multi-locus adj), 0.32; 95% confidence interval, 0.14-0.77). Maternal TGF-beta3 variants had no effect on risk of PIH.


CONCLUSIONS
A fetal TGF-beta3 polymorphism (rs11466414) is associated with PIH in a predominantly Hispanic population.
Wilson
Melissa L
ML
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Desmond
Daniel H
DH
Goodwin
T Murphy
TM
Miller
David A
DA
Ingles
Sue Ann
SA
D015897:Comorbidity; D005260:Female; D005333:Fetus / Q000502:physiology*; D005838:Genotype; D005865:Gestational Age; D006630:Hispanic or Latino / Q000235:genetics*; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000208:ethnology* / Q000235:genetics*; D016015:Logistic Models; D010298:Parity; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011247:Pregnancy; D012189:Retrospective Studies; D053782:Transforming Growth Factor beta3 / Q000235:genetics*
D053782:Transforming Growth Factor beta3