title: A multinational, randomized, placebo-controlled trial to assess the immunogenicity, safety, and tolerability of live attenuated influenza vaccine coadministered with oral poliovirus vaccine in healthy young children.
abstract: Live attenuated influenza vaccine (LAIV) provides a useful tool to rapidly immunize populations in the developing world to prevent influenza outbreaks. In this noninferiority trial conducted in Asia and South America, where oral poliovirus vaccine (OPV) is still used, 2503 children aged 6 to <36 months with three polio immunizations were randomized to receive LAIV+OPV, placebo+OPV, or LAIV only. Immune responses in children receiving concomitant LAIV+OPV were noninferior to those observed in recipients of either vaccine alone. Response rates for different poliovirus types were similar in recipients of LAIV+OPV and placebo+OPV. Response rates to all influenza strains were similar in LAIV+OPV and LAIV-only recipients. Concomitant OPV and LAIV were safely administered to young children.
authors.affiliation: Programme on Infectious Diseases and Vaccine Sciences, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
authors.forename: Robert F
authors.initials: RF
authors.lastname: Breiman
authors.forename: W Abdullah
authors.initials: WA
authors.lastname: Brooks
authors.forename: Doli
authors.initials: D
authors.lastname: Goswami
authors.forename: Rosanna
authors.initials: R
authors.lastname: Lagos
authors.forename: Charissa
authors.initials: C
authors.lastname: Borja-Tabora
authors.forename: Claudio F
authors.initials: CF
authors.lastname: Lanata
authors.forename: Jaime A Cèspedes
authors.initials: JA
authors.lastname: Londoño
authors.forename: Lucy Chai See
authors.initials: LC
authors.lastname: Lum
authors.forename: Ruth
authors.initials: R
authors.lastname: Rappaport
authors.forename: Ahmad
authors.initials: A
authors.lastname: Razmpour
authors.forename: Robert E
authors.initials: RE
authors.lastname: Walker
authors.forename: William C
authors.initials: WC
authors.lastname: Gruber
authors.forename: Bruce D
authors.initials: BD
authors.lastname: Forrest
mesh_terms: D000914:Antibodies, Viral / Q000097:blood; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007115:Immunization Schedule; D007223:Infant; D007252:Influenza Vaccines / Q000008:administration & dosage* / Q000009:adverse effects / Q000276:immunology; D007251:Influenza, Human / Q000517:prevention & control*; D008297:Male; D011051:Poliomyelitis / Q000517:prevention & control*; D011055:Poliovirus Vaccine, Oral / Q000008:administration & dosage* / Q000009:adverse effects / Q000276:immunology; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D007252:Influenza Vaccines; D011055:Poliovirus Vaccine, Oral; D014613:Vaccines, Attenuated