Humanized mice for modeling human infectious disease: challenges, progress, and outlook.
Over 800 million people worldwide are infected with hepatitis viruses, human immunodeficiency virus (HIV), and malaria, resulting in more than 5 million deaths annually. Here we discuss the potential and challenges of humanized mouse models for developing effective and affordable therapies and vaccines, which are desperately needed to combat these diseases.
Legrand
Nicolas
N
Department of Cell Biology and Histology, Academic Medical Center of the University of Amsterdam, Amsterdam 1105 AZ, The Netherlands.
Ploss
Alexander
A
Balling
Rudi
R
Becker
Pablo D
PD
Borsotti
Chiara
C
Brezillon
Nicolas
N
Debarry
Jennifer
J
de Jong
Ype
Y
Deng
Hongkui
H
Di Santo
James P
JP
Eisenbarth
Stephanie
S
Eynon
Elizabeth
E
Flavell
Richard A
RA
Guzman
Carlos A
CA
Huntington
Nicholas D
ND
Kremsdorf
Dina
D
Manns
Michael P
MP
Manz
Markus G
MG
Mention
Jean-Jacques
JJ
Ott
Michael
M
Rathinam
Chozhavendan
C
Rice
Charles M
CM
Rongvaux
Anthony
A
Stevens
Sean
S
Spits
Hergen
H
Strick-Marchand
Hélène
H
Takizawa
Hitoshi
H
van Lent
Anja U
AU
Wang
Chengyan
C
Weijer
Kees
K
Willinger
Tim
T
Ziegler
Patrick
P
D000818:Animals; D035843:Biomedical Research / Q000639:trends*; D003141:Communicable Diseases; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice