Antinociceptive activity of the essential oil of Zingiber zerumbet.
In the present study, the rhizome essential oil from Zingiber zerumbet (Zingiberaceae) was evaluated for antinociceptive activity using chemical and thermal models of nociception, namely, the acetic acid-induced abdominal writhing test, the hot-plate test and the formalin-induced paw licking test. It was demonstrated that intraperitoneal administration of the essential oil of Z. zerumbet (EOZZ) at the doses of 30, 100 and 300 mg/kg produced significant dose-dependent inhibition of acetic acid-induced abdominal writhing, comparable to that of obtained with acetylsalicylic acid (100 mg/kg). At the same doses, the EOZZ produced significant dose-dependent increases in the latency time in the hot-plate test with respect to controls, and in the formalin-induced paw licking test, the EOZZ also significantly reduced the painful stimulus in both neurogenic and inflammatory phase of the test. In addition, the antinociceptive effect of the EOZZ in the formalin-induced paw licking test as well as hot-plate test was reversed by the nonselective opioid receptor antagonist, naloxone suggesting that the opioid system was involved in its analgesic mechanism of action. On the basis of these data, we concluded that the EOZZ possessed both central and peripheral antinociceptive activities which justifying its popular folkloric use to relieve some pain conditions.
Sulaiman
Mohd Roslan
MR
Department of Biomedical Science, University Putra Malaysia, Serdang, Malaysia. mrs@medic.upm.edu.my
Tengku Mohamad
Tengku Azam Shah
TA
Shaik Mossadeq
Wan Mastura
WM
Moin
Saidi
S
Yusof
Mazina
M
Mokhtar
Ahmad Fauzi
AF
Zakaria
Zainul Amiruddin
ZA
Israf
Daud Ahmad
DA
Lajis
Nordin
N
D019342:Acetic Acid; D000700:Analgesics / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005557:Formaldehyde; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009270:Naloxone / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000494:pharmacology; D009822:Oils, Volatile / Q000008:administration & dosage / Q000627:therapeutic use*; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy*; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011930:Reaction Time / Q000187:drug effects; D011957:Receptors, Opioid / Q000378:metabolism; D027343:Rhizome; D030521:Zingiberaceae / Q000737:chemistry*
D000700:Analgesics; D009292:Narcotic Antagonists; D009822:Oils, Volatile; D010936:Plant Extracts; D011957:Receptors, Opioid; D005557:Formaldehyde; D009270:Naloxone; D019342:Acetic Acid