title: Role of airway epithelium in engulfing apoptotic eosinophils.
abstract: BACKGROUND
  This study aims to investigate which recognition pathways are important in engulfing apoptotic eosinophils.
  
  
  METHODS
  Here, two epithelial cell were selected namely (large airway bronchial epithelial cells) LAECs and A549. The inhibition assay was examined by resting and dexamethasone-stimulated epithelial cells. Confocal microscopy confirmed the engulfment of apoptotic eosinophils.
  
  
  RESULTS
  Macrophages and LAECs recognized and phagocytosed apoptotic eosinophils. Dexamethasone and IL-1 increased the capacity of LAECs to engulf apoptotic eosinophils. More interestingly, inhibiting monoclonal antibodies (Mabs) abolished the uptake of apoptotic cells by LAECs.
  
  
  CONCLUSIONS
  On the basis of the above findings, the LAECs is capable of recognizing and engulfing apoptotic eosinophils and that enhanced by interleukin-1 (IL-1â) and dexamethasone.
authors.affiliation: Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, AlKharaj 11942, Saudi Arabia. falenzi@ksu.edu.sa
authors.forename: Faris Q
authors.initials: FQ
authors.lastname: Alenzi
mesh_terms: D017209:Apoptosis / Q000502:physiology*; D001980:Bronchi / Q000166:cytology*; D002478:Cells, Cultured; D003907:Dexamethasone / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004804:Eosinophils / Q000166:cytology / Q000502:physiology*; D004847:Epithelial Cells / Q000502:physiology; D005938:Glucocorticoids / Q000494:pharmacology; D006801:Humans; D020287:In Situ Nick-End Labeling; D007375:Interleukin-1 / Q000494:pharmacology; D011650:Pulmonary Alveoli / Q000166:cytology / Q000502:physiology
chemical_list: D005938:Glucocorticoids; D007375:Interleukin-1; D003907:Dexamethasone