Minute alveolar soft part sarcoma of the endocervix: the smallest ever published case.
Alveolar soft part sarcoma (ASPS) is a distinctive mesenchymal tumor of uncertain histogenesis, which is exceedingly rare in the uterine cervix. We herein report the smallest (1.6 mm) ever published case of ASPS of the endocervix with the characteristic histomorphology and immunohistochemical findings. One-year follow-up was uneventful. Because of its seemingly much better prognosis, it is important in routine practice to distinguish ASPS from adenocarcinoma of the cervix. This is facilitated by the awareness that ASPS can occur in this location and if there is doubt about the diagnosis on routinely stained sections, the appropriate immunohistochemical study should be performed. Owing to the small number of published ASPSs in the cervix, the optimal treatment strategy has yet to be determined.
Petersson
Fredrik
F
Department of Pathology, National University Health System, Singapore. fredrikpetersson@live.se
Michal
Michal
M
D000230:Adenocarcinoma / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D000328:Adult; D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / Q000378:metabolism*; D002584:Cervix Uteri / Q000378:metabolism* / Q000473:pathology; D019092:Conization; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D017570:MyoD Protein / Q000378:metabolism*; D018234:Sarcoma, Alveolar Soft Part / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D047368:Tumor Burden; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology
D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; D017570:MyoD Protein; C057363:MyoD1 myogenic differentiation protein; C069203:TFE3 protein, human