Computed tomography-based tumor volume in non-Hodgkin lymphoma: clinical correlation and comparison with magnetic resonance imaging.
OBJECTIVE
To evaluate the prognostic significance of tumor volume in computed tomographic (CT) images of non-Hodgkin lymphoma patients. To compare CT volumes with those measured by magnetic resonance imaging (MRI).


METHODS
Twenty-five patients with B cell-type non-Hodgkin lymphoma (16 men, 9 women, age range, 48-77 years) were imaged with CT at 5 time points. The volumes and volume reductions were associated with clinical characteristics and treatment outcome. The CT-derived tumor volumes were correlated with MRI volumes derived earlier for the same patients.


RESULTS
Good agreement was found between 1-dimensional (1D), 2D, and 3D analyses. The CT-derived median tumor volumes were 306 cm, 174 cm, 75 cm, 28 cm, and 15 cm at the 5 time points. These volumes were found to associate, for example, with mortality and tumor malignancy. The CT-based tumor volumes showed good correlation with MRI.


CONCLUSIONS
Tumor volume quantification is a powerful tool that associates with clinical characteristics and treatment outcome.
Rossi
Maija
M
Regional Medical Imaging Centre, Department of Diagnostic Radiology, Tampere University Hospital, Tampere, Finland. maija.rossi@pshp.fi
Pertovaara
Hannu
H
Dastidar
Prasun
P
Järvenpää
Ritva
R
Luukkaala
Tiina
T
Rautakunnas
Sylvia
S
Heinonen
Tomi
T
Eskola
Hannu
H
Soimakallio
Seppo
S
Kellokumpu-Lehtinen
Pirkko-Liisa
PL
D000368:Aged; D003287:Contrast Media; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D021621:Imaging, Three-Dimensional / Q000379:methods; D007472:Iohexol; D016393:Lymphoma, B-Cell / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011856:Radiographic Image Enhancement / Q000379:methods; D015203:Reproducibility of Results; D016019:Survival Analysis; D014057:Tomography, X-Ray Computed / Q000379:methods*; D016896:Treatment Outcome; D047368:Tumor Burden
D003287:Contrast Media; D007472:Iohexol