title: Thiazole analog as stearoyl-CoA desaturase 1 inhibitor.
abstract: SCD1 inhibition may represent a novel treatment for obesity, type-2 diabetes and related metabolic disorders. A prototype thiazole amide analog 13 (MF-152) was identified as an excellent tool in the study of SCD biology in animals.
authors.affiliation: Merck Frosst Centre for Therapeutic Research, 16711 TransCanada Hwy, Kirkland, Quebec, Canada. chunsing_li@merck.com
authors.forename: Chun Sing
authors.initials: CS
authors.lastname: Li
authors.forename: Liette
authors.initials: L
authors.lastname: Belair
authors.forename: Jocelyne
authors.initials: J
authors.lastname: Guay
authors.forename: Renata
authors.initials: R
authors.lastname: Murgasva
authors.forename: Wayne
authors.initials: W
authors.lastname: Sturkenboom
authors.forename: Yeeman K
authors.initials: YK
authors.lastname: Ramtohul
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.forename: Zheng
authors.initials: Z
authors.lastname: Huang
mesh_terms: D000284:Administration, Oral; D000818:Animals; D045744:Cell Line, Tumor; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D007004:Hypoglycemic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D010879:Piperazines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D051381:Rats; D013230:Stearoyl-CoA Desaturase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013844:Thiazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D004791:Enzyme Inhibitors; D007004:Hypoglycemic Agents; C544974:MF 152; D010879:Piperazines; D013844:Thiazoles; D013230:Stearoyl-CoA Desaturase