Chronic inflammatory disease, lymphoid tissue neogenesis and extranodal marginal zone B-cell lymphomas.
Chronic autoimmune or pathogen-induced immune reactions resulting in lymphoid neogenesis are associated with development of malignant lymphomas, mostly extranodal marginal zone B-cell lymphomas (MZBCLs). In this review we address (i) chemokines and adhesion molecules involved in lymphoid neogenesis; (ii) the autoimmune diseases and pathogens which are associated with development of B-cell lymphomas; (iii) the molecular mechanisms involved in the initiation and progression of MZBCL; and (iv) 'potential' mouse models for MZBCL.
Bende
Richard J
RJ
Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
van Maldegem
Febe
F
van Noesel
Carel J M
CJ
D000818:Animals; D001327:Autoimmune Diseases / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000378:metabolism; D018925:Chemokines / Q000378:metabolism; D002908:Chronic Disease; D006801:Humans; D008221:Lymphoid Tissue / Q000276:immunology* / Q000378:metabolism; D016393:Lymphoma, B-Cell / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D008954:Models, Biological; D014178:Translocation, Genetic
D015815:Cell Adhesion Molecules; D018925:Chemokines