Effect of tadalafil on renal resistivity and pulsatility index in partial ureteral obstruction.
BACKGROUND
To investigate the effect of tadalafil on Resistivity Index (RI) and Pulsatility Index (PI) in partial unilateral ureteral obstruction (PUUO).


METHODS
Twelve New Zealand rabbits were assigned into two groups. Baseline renal Doppler ultrasonography (USG) was performed in all rabbits. The rabbits in group 1 received tadalafil for a month (10 mg/72 h) and group 2 was defined as sham. After 1 month, in both groups left PUUO was created. Renal Doppler USG was performed to measure RI and PI parameters of both kidneys on the 4th hour and 1st and 3rd days postoperatively.


RESULTS
Baseline renal Doppler USG revealed that there was no difference between two kidneys in both groups. The differences in mean RI and PI values of the kidneys between the sham and tadalafil groups were not statistically significant. Compared with the preoperative values, postoperative RI and PI values for the left kidneys were significantly increased in the period from 4 h to 3 days postoperatively in the sham group (p < 0.05). However, mean RI and PI values were not increased in the tadalafil group when compared with the sham group and this difference between the two groups was significant (p < 0.05).


CONCLUSIONS
Tadalafil has a lowering affect on RI and PI in experimentally created PUUO.
Ayyildiz
Ali
A
Department of Second Urology Clinic, Ministry of Health Ankara Training and Research Hospital, Ankara, Turkey. urology52@yahoo.com
Kaya
Mahir
M
Karaguzel
Ersagun
E
Bumin
Ali
A
Akgul
Turgay
T
Aklan
Zeki
Z
Germiyanoğlu
Cankon
C
D000818:Animals; D001783:Blood Flow Velocity / Q000187:drug effects; D002243:Carbolines / Q000494:pharmacology*; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology*; D011673:Pulsatile Flow / Q000187:drug effects; D011817:Rabbits; D012079:Renal Circulation / Q000187:drug effects*; D000068581:Tadalafil; D018608:Ultrasonography, Doppler; D014517:Ureteral Obstruction / Q000503:physiopathology*; D014655:Vascular Resistance / Q000187:drug effects
D002243:Carbolines; D010726:Phosphodiesterase Inhibitors; D000068581:Tadalafil