Trend reversal in the frequency of mycoses in hematological neoplasias: autopsy results from 1976 to 2005.
BACKGROUND
Fungal infections of internal organs are a major complication for patients with hematological neoplasias. For more than 20 years, the frequency of such mycoses has been increasing with the aggressiveness of tumor treatment.


METHODS
Autopsy findings over a 30-year period (1976 to 2005) from a single institution (Institute of Pathology, University of Essen) were retrospectively classified according to basic disease, frequency of mycoses, kind of mycoses, organs involved, hematopoietic transplantation, and cause of death.


RESULTS
340 of 1591 autopsied patients with hematological neoplasias (21.4%) revealed an invasive mycosis. The proportion increased from about 10% before 1980 to some 30% in the 1990s but fell to 21% by 2005. The frequency of mycoses decreased significantly both for transplanted patients (from 47.5% to 30.3%) and for non-transplanted patients (from 29.8% to 16.4%). The rate of deaths due to mycosis also decreased. The relative frequency of candidal mycoses went down, while aspergilloses predominated. The organ most frequently involved was the lung.


CONCLUSIONS
The autopsy results signal a trend reversal in the leading complication of the treatment of hematological neoplasias and lend support to the assumption that antimycotic strategies are having a positive effect.
Donhuijsen
Konrad
K
Institut für Pathologie des Städtischen Klinikums Braunschweig, Celler Strasse 38, Braunschweig, Germany. k.donhuijsen@klinikum-braunschweig.de
Petersen
Peter
P
Schmid
Werner Kurt
WK