[Leucocytosis and leucocyte adhesion in brain ischemia development].
Our previos studies revealed the phenomenon of leucocyte adhesion to microvessel walls in gradually developing brain ischemia. The problem of effect of the blood leucocyte number in the brain ischemia upon number of the adhesion acts was considered. This work attempts to solve this problem. Number of leucocytes was measured in the white rat blood after bilateral ligation of the carotid arteries and gradual increment of the brain ischemia. Simultaneously a number of leucocytes that adhered to the brain venule wall internal surface was recorded. Beginning of the ischemia was shown to quickly increase the number of leucocytes in the blood. In 2 hours, the number increased over two-fold. At this moment, the number of adhered leucocytes practically did not increase. In 3 hours, the number of the blood leucocytes started decreasing, whereas the number of the adhered leucocytes started increasing. By the 5th hour after artery ligation, the number of the blood leucocytes decreased to initial value, whereas the number of adhered leucocytes increased over 2.5-fold. The leucocytes adhesion seems to be unrelated to increase of their number in the blood. Reduction of the leucocyte amount in the blood on the 5th hour of the ischemia is associated with increase of the leucocyte adhesion acts in the brain. Reduction of the blood leucocyte number in grave ischemia of the brain might be a sign of increase of the leucocyte adhesion act number which leads to worsening of microcirculation and perishing of the organism.
Ivanov
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D000818:Animals; D001921:Brain / Q000098:blood supply*; D002545:Brain Ischemia / Q000097:blood* / Q000150:complications / Q000473:pathology; D002448:Cell Adhesion; D004195:Disease Models, Animal; D004730:Endothelium, Vascular / Q000473:pathology; D007958:Leukocyte Count; D007962:Leukocytes / Q000166:cytology / Q000473:pathology*; D007964:Leukocytosis / Q000097:blood* / Q000150:complications / Q000473:pathology; D008297:Male; D055806:Microvessels / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar