title: Osteogenic biphasic calcium sulphate dihydrate/iron-modified alpha-tricalcium phosphate bone cement for spinal applications: in vivo study.
abstract: In this study, the biocompatibility and the osteogenic features of a new iron-modified alpha-tricalcium phosphate (IM/alpha-TCP) and calcium sulphate dihydrate (CSD) biphasic cement (IM/alpha-TCP/CSD-BC) have been investigated in terms of the in vivo cement resorption, bone tissue formation and host tissue response on sheep animal model. Histological evaluation performed on undecalcified cement-bone specimens assessed the in vivo behaviour. It has been shown that the new IM/alpha-TCP/CSD-BC has the ability to produce firm bone binding in vivo (i.e. bioactivity). Qualitative histology proved cement biocompatibility, osteoconduction and favourable resorption, mainly through a macrophage-mediated mechanism. The results showed that the new cements have biocompatible and osteogenic features of interest as possible cancellous bone replacement biomaterial for minimally invasive spinal surgery applications.
authors.affiliation: Interdepartment Research Group for the Applied Scientific Collaboration (IRGASC), Division of Biomaterials & Bioengineering, Technical University of Catalonia (UPC), Avda. Diagonal 647, Barcelona, Spain.
authors.forename: M D
authors.initials: MD
authors.lastname: Vlad
authors.forename: E V
authors.initials: EV
authors.lastname: Sindilar
authors.forename: M L
authors.initials: ML
authors.lastname: Mariñoso
authors.forename: I
authors.initials: I
authors.lastname: Poeată
authors.forename: R
authors.initials: R
authors.lastname: Torres
authors.forename: J
authors.initials: J
authors.lastname: López
authors.forename: M
authors.initials: M
authors.lastname: Barracó
authors.forename: E
authors.initials: E
authors.lastname: Fernández
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D001843:Bone Cements; D002130:Calcium Phosphates / Q000008:administration & dosage* / Q000737:chemistry; D002133:Calcium Sulfate / Q000008:administration & dosage*; D005260:Female; D007501:Iron / Q000737:chemistry*; D012756:Sheep; D013131:Spine / Q000601:surgery*
chemical_list: D001672:Biocompatible Materials; D001843:Bone Cements; D002130:Calcium Phosphates; D007501:Iron; C018392:tricalcium phosphate; D002133:Calcium Sulfate