Passage-delaying microbeads for controlled delivery of loratadine.
A passage-delaying, multiple unit, controlled release system of loratadine was designed to increase residence time in the stomach involving minimum contact with the gastric mucosa. Oil-entrapped floating microbeads prepared using the emulsion gelation method were optimized by a 2(3) factorial design and a polymer ratio of 1.5:0.5 (casein:sodium alginate) by weight, and 15% w/v of oil (mineral oil/castor oil) and 1 M calcium chloride solution were selected as the optimized processing conditions for the desired buoyancy and physical stability. In vitro drug release in acid phthalate buffer, pH 3.12, demonstrated a sustained release for 8 h that best fitted the peppas model with n < 0.45. The ethylcellulose coating of the passage-delaying microbeads optimized by a 2(2) factorial design resulted in a controlled release formulation of loratadine that provided zero-order release for 8 h.
Mishra
Shashi Kiran
SK
Department of Pharmaceutics, Rajiv Academy for Pharmacy, Delhi Mathura Bypass, Mathura- 281001, Uttar Pradesh, India.
Philip
Anil K
AK
Pathak
Kamla
K
D002152:Calorimetry, Differential Scanning; D003692:Delayed-Action Preparations; D006863:Hydrogen-Ion Concentration; D017336:Loratadine / Q000008:administration & dosage* / Q000737:chemistry; D008863:Microspheres; D012995:Solubility
D003692:Delayed-Action Preparations; D017336:Loratadine