title: Advances in gene delivery through molecular design of cationic lipids.
abstract: This feature article describes the recent developments in the design of cationic lipids and their applications in gene delivery. Various structure-activity investigations explaining the variations in gene transfection efficacies with respect to different molecular structures of the cationic lipids have been discussed. Gene transfer abilities are presented in relation to aggregation properties of different aqueous formulations such as cationic liposomes and surfactant aggregates from various amphiphiles and cationic lipids, as a function of their hydrophobic parts, linkers and head groups.
authors.affiliation: Department of Organic Chemistry, Indian Institute of Science, Bangalore 560 012, India. sb@orgchem.iisc.ernet.in
authors.forename: Santanu
authors.initials: S
authors.lastname: Bhattacharya
authors.forename: Avinash
authors.initials: A
authors.lastname: Bajaj
mesh_terms: D000818:Animals; D002412:Cations; D015195:Drug Design; D018014:Gene Transfer Techniques; D006801:Humans; D008055:Lipids / Q000737:chemistry*; D008954:Models, Biological
chemical_list: D002412:Cations; D008055:Lipids