title: [An autopsy case of hepatocellular carcinoma in which sarcoma-like changes and peritoneal dissemination were observed after RFA/TACE treatment].
abstract: The patient was a 79-year-old male. In December 2002, US findings suggested hepatocellular carcinoma, and he was admitted. Liver biopsy led to a diagnosis of well-differentiated hepatocellular carcinoma. Radio frequency ablation (RFA) was performed. Then, regional relapse was detected, and treatment was repeated. However, follow-up with periodic imaging was continued based on the patient's wishes. RFA was completed in December 2005, and TAI in February 2006. In December 2007, abdominal swelling occurred. CT revealed pleural effusion/ascites and nodular tumor in the adipose tissue of the parietal peritoneum and mesentery around the liver. The patient died due to rapid deterioration. Autopsy revealed a tumor involving the liver surface to the peritoneum, suggesting cancerous peritonitis. Histopathologically, liver cancer showed sarcoma-like changes, directly infiltrating the liver surface to the peritoneum. Hepatocellular carcinoma with sarcoma-like changes and peritoneal dissemination is rare. In the present case, it was possible to compare imaging changes with autopsy findings. We report this patient and review the literature.
authors.affiliation: Dept. of Gastroenterology, Murakami Memorial Hospital, Asahi University.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Obora
authors.forename: Takao
authors.initials: T
authors.lastname: Kojima
authors.forename: Takahiro
authors.initials: T
authors.lastname: Kato
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Matsuda
authors.forename: Hideki
authors.initials: H
authors.lastname: Horie
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Hashimoto
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Fukuta
authors.forename: Yukihiko
authors.initials: Y
authors.lastname: Takano
authors.forename: Junichi
authors.initials: J
authors.lastname: Okuda
authors.forename: Kazunori
authors.initials: K
authors.lastname: Ida
authors.forename: Masanao
authors.initials: M
authors.lastname: Saio
mesh_terms: D000368:Aged; D001344:Autopsy; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D017115:Catheter Ablation; D016461:Chemoembolization, Therapeutic; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D008297:Male; D010537:Peritoneum / Q000473:pathology; D011859:Radiography