[Study on pharmacokinetics model for targeted drug delivery systems].
Multi-compartment linear circulation mathematical model for targeted drug delivery systems was established on the bases of compartment theory and mass conservation theory. The function formulas of drug concentration-time in blood and target organ were established. According to this model, the drug concentration-time curve for the target organ can be plotted with reference to the data on blood. Based on the target organ drug concentration-time curve,the pharmacokinetics parameters of the target organ can also be calculated by the statistical moment. We further detected the practicability of the models by using the experimental data of drug concentration-time curve in blood and target organ of microspheres. The drug concentration-time curve in blood and in target organ predicted by mathematical model was agreed with that observed.
Li
Lingbing
L
Department of Pharmaceutics, Shandong University, Jinan 250012, China. cnlbli@sdu.edu.cn
Wei
Pei
P
Liu
Junyi
J
D000418:Albumins / Q000008:administration & dosage; D016503:Drug Delivery Systems; D006801:Humans; D008863:Microspheres; D008962:Models, Theoretical; D010599:Pharmacokinetics
D000418:Albumins