title: [Chemoprevention of colorectal cancer].
abstract: Gastrointestinal cancer poses a major clinical challenge in the developed world where the disease is common. Cancer chemoprevention is defined as the use of natural, synthetic or chemical agents to reverse, suppress or prevent carcinogenic progression to invasive cancer. The success of several clinical trials in preventing cancer in high-risk populations suggests that chemoprevention can be rational strategy. Besides, in population-based observational studies, people had lower rates of colorectal cancer if they were taking various agents, including nonsteroidal anti-inflammatory drugs, calcium, folate. Cyclooxygenase-2 inhibitors and NSAIDs reduce the incidence of colonic adenomas. However, these agents are associated with important cardiovascular events and gastrointestinal harms. Contemporary, the balance of benefits to risk does not favor chemoprevention in average-risk individualse.
authors.affiliation: Military Institute of Health Services in Warsaw, Department of Gastroenterology, Central Clinical Hospital of the Ministry of National Defense. stel56@wp.pl
authors.forename: Tomasz
authors.initials: T
authors.lastname: Stelmaszuk
authors.forename: Lukasz
authors.initials: L
authors.lastname: Jałocha
authors.forename: Stanisław
authors.initials: S
authors.lastname: Wojtuń
authors.forename: Jerzy
authors.initials: J
authors.lastname: Gil
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000627:therapeutic use; D002318:Cardiovascular Diseases / Q000139:chemically induced; D002762:Cholecalciferol / Q000627:therapeutic use; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000517:prevention & control*; D052246:Cyclooxygenase 2 Inhibitors / Q000009:adverse effects / Q000627:therapeutic use; D005492:Folic Acid / Q000627:therapeutic use; D005767:Gastrointestinal Diseases / Q000139:chemically induced; D006801:Humans; D018570:Risk Assessment
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D052246:Cyclooxygenase 2 Inhibitors; D002762:Cholecalciferol; D005492:Folic Acid