title: Association analysis of serotonin receptor 1B (HTR1B) and brain-derived neurotrophic factor gene polymorphisms in Borderline personality disorder.
abstract: The purpose of this study was to test for association between Borderline personality disorder (BPD) and variants of the HTR1B and the brain-derived neurotrophic factor (BDNF) gene. We genotyped four HTR1B and the functional BDNF G196A marker in 161 Caucasian BPD patients and 156 healthy controls. There were no significant differences between groups in genotype or haplotype distribution of HTR1B markers or in genotype distribution of the BDNF marker. Logistic regression analyses revealed an over-representation of the BDNF 196A allele in HTR1B A-161 allele carrying BPD patients.
authors.affiliation: Department of Psychiatry and Psychotherapy, University of Mainz, Mainz, Germany. tadic@uni-mainz.de
authors.forename: André
authors.initials: A
authors.lastname: Tadić
authors.forename: Amelie
authors.initials: A
authors.lastname: Elsässer
authors.forename: Anja
authors.initials: A
authors.lastname: Victor
authors.forename: Robert
authors.initials: R
authors.lastname: von Cube
authors.forename: Omür
authors.initials: O
authors.lastname: Başkaya
authors.forename: Stefanie
authors.initials: S
authors.lastname: Wagner
authors.forename: Klaus
authors.initials: K
authors.lastname: Lieb
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Höppner
authors.forename: Norbert
authors.initials: N
authors.lastname: Dahmen
mesh_terms: D000328:Adult; D001883:Borderline Personality Disorder / Q000235:genetics*; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D044302:Receptor, Serotonin, 5-HT1B / Q000235:genetics*; D044465:White People
chemical_list: D019208:Brain-Derived Neurotrophic Factor; C470302:HTR1B protein, human; D044302:Receptor, Serotonin, 5-HT1B