Potential anti-cancer activities of Furanodiene, a Sesquiterpene from Curcuma wenyujin.
Furanodiene is a sesquiterpene extracted from the essential oil of the rhizome of Curcuma wenyujin Y.H. Chen et C. Ling (Wen Ezhu). Furanodiene is the primary component in Wen Ezhu's essential oil, accounting for more than 20% by weight. In vitro, MTT assay was used to compare the inhibitory effects of furanodiene and Wen Ezhu's essential oil on 11 human cancer cell lines. Compared to the essential oil, furanodiene showed stronger growth inhibitions on Hela, Hep-2, HL-60, PC3, SGC-7901 and HT-1080 cells with IC(50) between 0.6-4.8 microg/ml. In vivo, furanodiene was also found to exhibit inhibitory effects on the growth of uterine cervical (U14) and sarcoma 180 (Sl80) tumors in mice. Our data suggests that furanodiene, an active component from the essential oil of Wen Ezhu, possesses efficacy against uterine cervical cancer.
Sun
Xiu-Yan
XY
School of Pharmaceutical Science, Yantai University, Yantai 264005, China.
Zheng
Yan-Ping
YP
Lin
Dong-Hai
DH
Zhang
Hui
H
Zhao
Feng
F
Yuan
Chun-Su
CS
D000230:Adenocarcinoma; D000818:Animals; D001943:Breast Neoplasms; D006528:Carcinoma, Hepatocellular; D002455:Cell Division / Q000187:drug effects; D030024:Curcuma; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D005354:Fibrosarcoma / Q000188:drug therapy / Q000473:pathology; D005663:Furans / Q000494:pharmacology*; D018922:HL-60 Cells; D006367:HeLa Cells; D006574:Heterocyclic Compounds, 2-Ring / Q000494:pharmacology*; D006801:Humans; D020014:K562 Cells; D007938:Leukemia; D008113:Liver Neoplasms; D008175:Lung Neoplasms; D051379:Mice; D008815:Mice, Inbred Strains; D009929:Organ Size; D012717:Sesquiterpenes / Q000494:pharmacology*; D013154:Spleen / Q000473:pathology; D013950:Thymus Gland / Q000473:pathology; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy* / Q000473:pathology; D023041:Xenograft Model Antitumor Assays
D004365:Drugs, Chinese Herbal; D005663:Furans; D006574:Heterocyclic Compounds, 2-Ring; D012717:Sesquiterpenes; C442489:furanodiene