title: Imaging-guided percutaneous biopsy of pathologic fractures: a retrospective analysis of 129 cases.
abstract: OBJECTIVE
  The purpose of our study was to determine the diagnostic performance of imaging-guided percutaneous needle core biopsy and the factors associated with a nondiagnostic biopsy in patients with a pathologic fracture of the appendicular skeleton.
  
  
  METHODS
  A retrospective audit was performed of 129 consecutive patients presenting with a pathologic fracture. All patients underwent percutaneous needle core biopsy using CT (n = 98), fluoroscopy (n = 15), or ultrasound (n = 16) guidance. In all cases, either MRI or CT was available before biopsy to assess the presence and degree of the extraosseous tumor mass. The resulting sample was classified as diagnostic (group 1) or nondiagnostic (group 2) on histopathologic study. Diagnostic performance was evaluated on the basis of the diagnostic yield and the diagnostic accuracy, and these were related to the site of the lesion and presence or absence of an extraosseous mass.
  
  
  RESULTS
  Ninety-nine masses (77%) were classified as group 1 and 30 (23%) as group 2. The average cross-sectional diameter of lesions in group 1 was 5.7 x 5.9 cm. Of the 30 lesions composing group 2, no soft-tissue component was identified on prebiopsy cross-sectional imaging in 27 lesions (90%), but the remaining three (10%) showed a smaller extraosseous soft-tissue component compared with the lesions in group 1.
  
  
  CONCLUSIONS
  Imaging-guided core biopsy is a reliable method for obtaining a tissue diagnosis in pathologic fracture of the appendicular skeleton with a high rate of accuracy. However, those lesions that are purely intraosseous or have only very small extraosseous components are more likely to be associated with a nondiagnostic biopsy and should be considered for a primary open procedure.
authors.affiliation: Department of Radiology, The Royal National Orthopaedic Hospital NHS Trust, Brockley Hill, Stanmore, Middlesex, United Kingdom HA7 4LP. apdatir@gmail.com
authors.forename: Abhijit
authors.initials: A
authors.lastname: Datir
authors.forename: Pierre
authors.initials: P
authors.lastname: Pechon
authors.forename: Asif
authors.initials: A
authors.lastname: Saifuddin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle / Q000379:methods*; D001859:Bone Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000556:secondary; D002648:Child; D002675:Child, Preschool; D005260:Female; D005471:Fluoroscopy; D050723:Fractures, Bone / Q000209:etiology / Q000473:pathology*; D005598:Fractures, Spontaneous / Q000209:etiology / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019042:Muscle Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000556:secondary; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography / Q000379:methods; D055815:Young Adult