Multicomponent reactions for the synthesis of multifunctional agents with activity against cancer cells.
Multicomponent Passerini and Ugi reactions enable the fast and efficient synthesis of redox-active multifunctional selenium and tellurium compounds, of which some show considerable cytotoxicity against specific cancer cells.
Shabaan
Saad
S
Division of Bioorganic Chemistry, School of Pharmacy, Saarland University, D-66123 Saarbruecken, Germany.
Ba
Lalla A
LA
Abbas
Muhammad
M
Burkholz
Torsten
T
Denkert
Annika
A
Gohr
André
A
Wessjohann
Ludger A
LA
Sasse
Florenz
F
Weber
Wolfgang
W
Jacob
Claus
C
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry; D045744:Cell Line, Tumor; D006801:Humans; D020128:Inhibitory Concentration 50; D051379:Mice; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D010084:Oxidation-Reduction; D012643:Selenium / Q000737:chemistry*; D013691:Tellurium / Q000737:chemistry*
D000970:Antineoplastic Agents; D009942:Organometallic Compounds; D012643:Selenium; D013691:Tellurium