An fMRI examination of visual integration in schizophrenia.
Behavioral and electrophysiological studies of schizophrenia have consistently demonstrated impairments in the integration of visual features into unified perceptual representations. Specific brain regions involved in this dysfunction, however, remain to be clarified. This study used functional Magnetic Resonance Imaging (fMRI) to examine the relative involvement of visual cortex areas (involved in form perception) and parietal and frontal regions (involved in attention), in the visual integration impairment in schizophrenia. Fourteen patients with schizophrenia and 14 healthy controls were compared on behavioral performance and data acquired via fMRI while completing a contour integration task that had previously been used to identify a visual integration deficit in schizophrenia. The schizophrenia patients demonstrated poorer visual integration than controls. Analyses of peak signal change indicated that while the groups were equivalent in area V1, the schizophrenia group demonstrated reduced signal in areas V2-V4, which are the earliest regions sensitive to global configurations of stimuli. Moreover, whereas the control group demonstrated greater recruitment of prefrontal and parietal areas during perception of integrated forms compared to random stimuli, the schizophrenia group demonstrated greater recruitment of frontal regions during perception of random stimuli. The two groups differed on brain regions involved in form perception even when they were matched on accuracy levels. The visual integration disturbance in schizophrenia involves both deficient basic visual processes (beginning as early as occipital region V2), as well as reduced feedback from visual attention regions that normally serves to amplify relevant visual representations relative to irrelevant information.
Silverstein
Steven M
SM
University of Medicine and Dentistry of New Jersey, USA. silvers1@umdnj.edu
Berten
Sarah
S
Essex
Brian
B
Kovács
Ilona
I
Susmaras
Teresa
T
Little
Deborah M
DM
D000293:Adolescent; D000328:Adult; D001288:Attention / Q000502:physiology; D001931:Brain Mapping / Q000379:methods; D005246:Feedback / Q000502:physiology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010364:Pattern Recognition, Visual / Q000502:physiology; D010468:Perceptual Disorders / Q000209:etiology / Q000503:physiopathology*; D010775:Photic Stimulation; D012559:Schizophrenia / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D014793:Visual Cortex / Q000033:anatomy & histology / Q000503:physiopathology*; D014795:Visual Pathways / Q000503:physiopathology; D014796:Visual Perception / Q000502:physiology*; D055815:Young Adult