title: Design of selective Cathepsin inhibitors.
abstract: A number of molecular recognition features have been exploited in structure-based design of selective Cathepsin inhibitors.
authors.affiliation: RIRA, AstraZeneca, Mereside, Alderley Park, Macclesfield SK10 4TG, UK.
authors.forename: Paul A
authors.initials: PA
authors.lastname: Bethel
authors.forename: Stefan
authors.initials: S
authors.lastname: Gerhardt
authors.forename: Emma V
authors.initials: EV
authors.lastname: Jones
authors.forename: Peter W
authors.initials: PW
authors.lastname: Kenny
authors.forename: Galith I
authors.initials: GI
authors.lastname: Karoutchi
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Morley
authors.forename: Keith
authors.initials: K
authors.lastname: Oldham
authors.forename: Neil
authors.initials: N
authors.lastname: Rankine
authors.forename: Martin
authors.initials: M
authors.lastname: Augustin
authors.forename: Stephan
authors.initials: S
authors.lastname: Krapp
authors.forename: Hannes
authors.initials: H
authors.lastname: Simader
authors.forename: Stefan
authors.initials: S
authors.lastname: Steinbacher
mesh_terms: D002403:Cathepsins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D003198:Computer Simulation; D018360:Crystallography, X-Ray; D015195:Drug Design; D011480:Protease Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D011480:Protease Inhibitors; D002403:Cathepsins