title: Laryngeal cancer in acquired immunodeficiency syndrome.
abstract: With improved survival, more AIDS patients, especially heavy smokers and alcohol abusers, may be confronted with laryngeal squamous cell carcinoma. Since curative treatment may require aggressive combined therapy, these patients, often suffering from immunosupression and poor general condition, present unique therapeutic challenges. The objective of the study was to describe treatment dilemmas. This case report presents a detailed description of an AIDS patient with carcinoma of the larynx. A patient with T3N0M0 laryngeal carcinoma and AIDS underwent tracheotomy and biopsy, followed by severe neck and pulmonary infection. After convalescence, radiotherapy was administered, with no evidence of a disease during a 3.5-year follow-up. During his remaining life, the patient developed severe psychoaffective disorder, his immune state deteriorated until he demised from sepsis. In conclusion, patients with HIV infection, especially having a history of tobacco or alcohol abuse, should be carefully examined for head and neck carcinoma that is likely to be more aggressive. Following surgery, AIDS patients may have worse wound healing and a greater tendency to contract infections. Radiotherapy and especially chemotherapy may cause life-threatening complications. Although early detection may increase survival, curative treatment should involve many disciplines and extra caution.
authors.affiliation: Department of Otolaryngology-Head & Neck Surgery and Tel Aviv University Sackler School of Medicine, The Edith Wolfson Medical Center, Holon, Israel.
authors.forename: S
authors.initials: S
authors.lastname: Shushan
authors.forename: U
authors.initials: U
authors.lastname: Cinamon
authors.forename: D
authors.initials: D
authors.lastname: Levy
authors.forename: M
authors.initials: M
authors.lastname: Sokolov
authors.forename: Y
authors.initials: Y
authors.lastname: Roth
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000503:physiopathology; D018791:CD4 Lymphocyte Count; D006801:Humans; D007822:Laryngeal Neoplasms / Q000209:etiology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D014945:Wound Healing