Lipase-catalyzed ring-opening polymerization of the O-carboxylic anhydride derived from lactic acid.
Both lipase PS and Novozym 435 promote the ring-opening polymerization of lacOCA, the O-carboxylic anhydride derived from lactic acid. Accordingly, PLA of relatively high molecular weights (M(n) up to 38400 g/mol) and low polydispersities (M(w)/M(n) < 1.4) are obtained in high yields within a few hours at 80 degrees C. Slight preference for l-lacOCA over d-lacOCA is observed, and with Novozym 435, the molecular weight of the obtained PLA can be controlled by varying the lipase loading.
Bonduelle
Colin
C
Université de Toulouse, UPS, Laboratoire Hétérochimie Fondamentale et Appliquée (LHFA), Toulouse, France.
Martin-Vaca
Blanca
B
Bourissou
Didier
D
D000812:Anhydrides / Q000737:chemistry / Q000494:pharmacology; D001672:Biocompatible Materials / Q000737:chemistry / Q000494:pharmacology; D002264:Carboxylic Acids / Q000737:chemistry / Q000494:pharmacology; D002384:Catalysis / Q000187:drug effects; D005656:Fungal Proteins; D007773:Lactates / Q000737:chemistry* / Q000494:pharmacology; D019344:Lactic Acid / Q000737:chemistry / Q000494:pharmacology; D008049:Lipase / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D008970:Molecular Weight; D011108:Polymers / Q000737:chemistry* / Q000494:pharmacology; D011549:Pseudomonas / Q000201:enzymology
D000812:Anhydrides; D001672:Biocompatible Materials; D002264:Carboxylic Acids; D005656:Fungal Proteins; D007773:Lactates; D011108:Polymers; C531379:lactic O-carboxylic anhydride; D019344:Lactic Acid; D008049:Lipase; C431349:lipase B, Candida antarctica