title: Selenium and the methionine sulfoxide reductase system.
abstract: Selenium is a chemical element participating in the synthesis of selenocysteine residues that play a pivotal role in the enzymatic activity efficiency of selenoproteines. The methionine sulfoxide reductase (Msr) system that reduces methionine sulfoxide (MetO) to methionine comprises the selenoprotein MsrB (MsrB1) and the non-selenoprotein MsrA, which reduce the R- and the S- forms of MetO, respectively. The effects of a selenium deficient (SD) diet, which was administrated to wild type (WT) and MsrA knockout mice (MsrA(-)/(-)), on the expression and function of Msr-related proteins are examined and discussed. Additionally, new data about the levels of selenium in brain, liver, and kidneys of WT and MsrA(-)/(-) mice are presented and discussed.
authors.affiliation: Department of Pharmacology and Toxicology, School of Pharmacy, University of Kansas, Lawrence, KS 66045, USA. moskovij@ku.edu
authors.forename: Derek B
authors.initials: DB
authors.lastname: Oien
authors.forename: Jackob
authors.initials: J
authors.lastname: Moskovitz
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D004032:Diet; D007668:Kidney / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D051150:Methionine Sulfoxide Reductases; D051379:Mice; D018345:Mice, Knockout; D010088:Oxidoreductases / Q000235:genetics / Q000378:metabolism*; D012643:Selenium / Q000008:administration & dosage / Q000378:metabolism*
chemical_list: D010088:Oxidoreductases; D051150:Methionine Sulfoxide Reductases; C027219:methionine sulfoxide reductase; D012643:Selenium