[Helicobacter pylori infection in the gastric mucosa of patients with HIV/AIDS in different clinical stages].
OBJECTIVE
To analyze Helicobacter pylori infection in the gastric mucosa of patients with HIV/AIDS in different clinical stages.


METHODS
This study involved 170 patients with HIV/AIDS and 34 HIV-negative patients. All the patients underwent upper endoscopy and antral gastric biopsy to determine the status of Helicobacter pylori infection using aniline red staining and rapid urease test. The patients with HIV/AIDS were stratified based on CD4(+)T lymphocyte counts and clinical setting into asymptomatic HIV infection (A1, A2) group, symptomatic HIV infection (B1, B2) group and AIDS (A3, B3, C1-3) group.


RESULTS
The prevalence of Helicobacter pylori infection in HIV/AIDS patients was 16.5% (28/170), and in the 3 groups classified, the infection rates were 23.4% (11/47), 14.0% (8/57), and 13.6% (9/66), respectively; the infection rate was 47.1% (16/34) in the control group. Helicobacter pylori infection rate in the gastric mucosa of the patients with HIV/AIDS in different clinical stages was significantly lower than that of the control group (P<0.05); the infection rates in symptomatic HIV-infected (B1, B2) group and AIDS (A3, B3, C1-3) group were significantly lower than that in asymptomatic HIV-infected (A1, A2) group (P<0.05).


CONCLUSIONS
The low Helicobacter pylori infection rate in HIV/AIDS patients may result from severe immunodeficiency in the gastric mucosa.
Luo
Hong-Bin
HB
Department of Gastroenterology, Guangzhou Eighth People's Hospital, Guangzhou 510060, China. lhb37777@163.com
Hu
Zhong-Wei
ZW
Guo
Jia-Wei
JW
D017088:AIDS-Related Opportunistic Infections / Q000382:microbiology / Q000473:pathology; D000163:Acquired Immunodeficiency Syndrome / Q000382:microbiology* / Q000473:pathology; D000328:Adult; D005260:Female; D005753:Gastric Mucosa / Q000382:microbiology*; D005773:Gastroscopy; D015658:HIV Infections / Q000382:microbiology* / Q000473:pathology; D016481:Helicobacter Infections / Q000453:epidemiology* / Q000473:pathology; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged