title: Stroke secondary to calcific bicuspid aortic valve: case report and literature review.
abstract: BACKGROUND
  Aortic valve calcification is common in rheumatic endocarditis, elderly patients, and congenital bicuspid aortic valve. It is not a recognized risk factor for stroke. We report a case of non-calcific embolization from calcified bicuspid aortic valve.
  
  
  METHODS
  A 52-year-old male with bicuspid aortic valve presented with aphasia and right arm weakness of less than 3h duration. CT head revealed hypodensity in the left middle cerebral artery (MCA) distribution and laboratory testing showed factor V leiden heterozygosity. The patient improved after intra-arterial tissue plasminogen activator (t-PA), but developed recurrence of right sided hemiparesis and silent myocardial infarction (MI). Cerebral angiography revealed clot in the left MCA. The patient received t-PA followed by transcatheter clot retrieval and was started on anticoagulation.
  
  
  CONCLUSIONS
  Embolization from calcific bicuspid aortic valves can lead to stroke and MI. Conservative management with anticoagulation for treatment of associated poststagnation thrombosis or aortic valve replacement as treatment is debatable. This patient was successfully managed with anticoagulation.
authors.affiliation: Department of Medicine, Detroit Medical Center, Wayne State University School of Medicine, Detroit, MI, USA. nitin9696@yahoo.com
authors.forename: Nitin
authors.initials: N
authors.lastname: Mahajan
authors.forename: Vipin
authors.initials: V
authors.lastname: Khetarpal
authors.forename: Luis
authors.initials: L
authors.lastname: Afonso
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use; D001021:Aortic Valve / Q000002:abnormalities* / Q000473:pathology; D002114:Calcinosis; D006349:Heart Valve Diseases / Q000150:complications; D006801:Humans; D020766:Intracranial Embolism / Q000188:drug therapy / Q000209:etiology; D008297:Male; D008875:Middle Aged; D020521:Stroke / Q000209:etiology*
chemical_list: D000925:Anticoagulants