title: Prenatal airborne polycyclic aromatic hydrocarbon exposure and child IQ at age 5 years.
abstract: OBJECTIVE
  This study evaluated the relationship between prenatal exposure to airborne polycyclic aromatic hydrocarbons (PAHs) and child intelligence.
  
  
  METHODS
  Children of nonsmoking black or Dominican-American women residing in New York City were monitored from in utero to 5 years of age, with determination of prenatal PAH exposure through personal air monitoring for the mothers during pregnancy. At 5 years of age, intelligence was assessed for 249 children by using the Wechsler Preschool and Primary Scale of Intelligence-Revised. Multivariate linear regression models were used to estimate and to test the associations between prenatal PAH exposure and IQ.
  
  
  RESULTS
  After adjustment for maternal intelligence, quality of the home caretaking environment, environmental tobacco smoke exposure, and other potentially confounding factors, high PAH levels (above the median of 2.26 ng/m(3)) were inversely associated with full-scale IQ (P = .007) and verbal IQ (P = .003) scores. Children in the high-exposure group had full-scale and verbal IQ scores that were 4.31 and 4.67 points lower, respectively, than those of less-exposed children (<or=2.26 ng/m(3)). The associations between logarithmically transformed, continuous, PAH levels and these IQ measures also were significant (full-scale IQ: beta = -3.00; P = .009; verbal IQ: beta = -3.53; P = .002).
  
  
  CONCLUSIONS
  These results provide evidence that environmental PAHs at levels encountered in New York City air can affect children's IQ adversely.
authors.affiliation: Department of Environmental Health Sciences, Columbia Center for Children's Environmental Healt, Mailman School of Public Health, Columbia University, New York, New York 10032, USA. fpp1@columbia.edu
authors.forename: Frederica P
authors.initials: FP
authors.lastname: Perera
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Li
authors.forename: Robin
authors.initials: R
authors.lastname: Whyatt
authors.forename: Lori
authors.initials: L
authors.lastname: Hoepner
authors.forename: Shuang
authors.initials: S
authors.lastname: Wang
authors.forename: David
authors.initials: D
authors.lastname: Camann
authors.forename: Virginia
authors.initials: V
authors.lastname: Rauh
mesh_terms: D000393:Air Pollutants / Q000633:toxicity*; D044383:Black People / Q000523:psychology*; D002675:Child, Preschool; D004293:Dominican Republic / Q000208:ethnology; D005260:Female; D005500:Follow-Up Studies; D006630:Hispanic or Latino / Q000523:psychology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007360:Intelligence / Q000187:drug effects*; D009519:New York City; D011084:Polycyclic Aromatic Hydrocarbons / Q000633:toxicity*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000523:psychology*; D014505:Urban Population; D014888:Wechsler Scales; D001741:Black or African American
chemical_list: D000393:Air Pollutants; D011084:Polycyclic Aromatic Hydrocarbons