title: Dual phase MIBI scintigraphy in diagnosis of parathyroid adenoma followed by ultrasound guided percutaneous alcoholic ablation.
abstract: Primary Hyperparathyroidism (HPT) is an inappropriate hyper secretion of parathyroid hormone (PTH). Primary HPT is caused by parathyroid adenoma in 80-85% of patients. Clinical manifestations are kidney stones, abdominal groans, painful bones, psychic moans, and fatigue overtones. Ultrasonography is widely used in suspected cases for localization of parathyroid adenoma. There is considerable intra-observer variation and it is difficult for ultrasound alone to differentiate parathyroid lesion form that of thyroid. Dual phase Tc-99m MIBI scinitigraphy for detection of parathyroid adenomas has sensitivity and specificity values ranging from 82% to 100% and from 89% to 100%, respectively. Percutaneous ethanol injection for parathyroid glands can be applied effectively in selected cases when surgery is unadvisable either for technical reasons (e.g., recurrence ofhyperplastic glands in the neck after subtotal surgery or intrathyroideal parathyroid tumors or the poor clinical state of the patient.
authors.affiliation: Department of Nuclear Medicine, Institute of Nuclear Medicine, Oncology and Radiotherapy, Mansehra Road Abbottabad, Pakistan. drshakilahmad@yahoo.com
authors.forename: Shakil
authors.initials: S
authors.lastname: Ahmad
authors.forename: Amjad Aziz Khan Asif
authors.initials: AA
authors.lastname: Jielani
authors.forename: Kamran
authors.initials: K
authors.lastname: Khan
authors.forename: Tatheer
authors.initials: T
authors.lastname: Fatima
authors.forename: Nadeem
authors.initials: N
authors.lastname: Zia
authors.forename: Mazhar
authors.initials: M
authors.lastname: ud Duha
authors.forename: Abdul
authors.initials: A
authors.lastname: Samad
authors.forename: Khalid
authors.initials: K
authors.lastname: Memon
mesh_terms: D000236:Adenoma / Q000000981:diagnostic imaging* / Q000628:therapy*; D000328:Adult; D017115:Catheter Ablation / Q000379:methods*; D000431:Ethanol / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D010282:Parathyroid Neoplasms / Q000000981:diagnostic imaging* / Q000628:therapy*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D017256:Technetium Tc 99m Sestamibi; D018084:Ultrasonography, Interventional
chemical_list: D019275:Radiopharmaceuticals; D000431:Ethanol; D017256:Technetium Tc 99m Sestamibi