Is MOF an outcome parameter or a transient, adaptive state in critical illness?
OBJECTIVE
The term 'multiorgan failure' (MOF) carries the negative connotation of major homeostatic breakdown and severe malfunction. However, this traditional paradigm may not be necessarily accurate. This review will investigate the rationale for no longer considering MOF to be simply a 'failed' pathophysiological state.


RESULTS
Multiorgan failure is characterized by a hypometabolic, immunodepressed state with clinical and biochemical evidence of decreased functioning of the body's organ systems. Notwithstanding these findings, evidence for cell death is scarce and organ recovery is frequently the rule in surviving patients without pre-existing organ disease. Decreased mitochondrial activity appears to play a key role in the processes underlying MOF, both as a victim and a player. Reduced ATP production will compromise normal metabolic functioning. To protect itself from dying, the cell may adapt by decreasing its metabolic rate, and this is clinically manifest as organ dysfunction. Mitochondrial modulation may thus represent an important therapeutic target.


CONCLUSIONS
The concept of MOF could be revisited as a transient state of metabolic shutdown analogous to hibernation. Avoiding the detrimental effects of inappropriate and counter-adaptive iatrogenic interventions is an important cornerstone of therapeutic management.
Mongardon
Nicolas
N
Bloomsbury Institute of Intensive Care Medicine, Department of Medicine, University College London, London, UK.
Dyson
Alex
A
Singer
Mervyn
M
D000222:Adaptation, Physiological; D016638:Critical Illness; D006801:Humans; D009102:Multiple Organ Failure / Q000401:mortality / Q000503:physiopathology* / Q000628:therapy; D013312:Stress, Physiological; D016019:Survival Analysis; D009626:Terminology as Topic