Association analysis of serotonin receptor 1B (HTR1B) and brain-derived neurotrophic factor gene polymorphisms in Borderline personality disorder.
The purpose of this study was to test for association between Borderline personality disorder (BPD) and variants of the HTR1B and the brain-derived neurotrophic factor (BDNF) gene. We genotyped four HTR1B and the functional BDNF G196A marker in 161 Caucasian BPD patients and 156 healthy controls. There were no significant differences between groups in genotype or haplotype distribution of HTR1B markers or in genotype distribution of the BDNF marker. Logistic regression analyses revealed an over-representation of the BDNF 196A allele in HTR1B A-161 allele carrying BPD patients.
Tadić
André
A
Department of Psychiatry and Psychotherapy, University of Mainz, Mainz, Germany. tadic@uni-mainz.de
Elsässer
Amelie
A
Victor
Anja
A
von Cube
Robert
R
Başkaya
Omür
O
Wagner
Stefanie
S
Lieb
Klaus
K
Höppner
Wolfgang
W
Dahmen
Norbert
N
D000328:Adult; D001883:Borderline Personality Disorder / Q000235:genetics*; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D044302:Receptor, Serotonin, 5-HT1B / Q000235:genetics*; D044465:White People
D019208:Brain-Derived Neurotrophic Factor; C470302:HTR1B protein, human; D044302:Receptor, Serotonin, 5-HT1B