title: Bingchamides A and B, two novel cyclic pentapeptides from the Streptomyces bingchenggensis: fermentation, isolation, structure elucidation and biological properties.
abstract: Two novel cyclic pentapeptides, bingchamides A (1) and B (2), have been isolated from the organic extracts of the mycelium of Streptomyces bingchenggensis. The structures of 1 and 2 were elucidated on the basis of extensive 1D and 2D NMR, as well as HRESI-MS, electrospray ionization-MS, UV and IR spectroscopic data analysis. Bingchamides A (1) and B (2) exhibited in vitro cytotoxicity toward human colon carcinoma cell line HCT-116 with the IC(50) values of 14.1 and 18.0 microg ml(-1), respectively. The bingchamides A (1) and B (2) scaffolds are probably promising structures for the development of new antitumor agents.
authors.affiliation: School of Life Science, Northeast Agricultural University, Harbin, China.
authors.forename: Wen-Sheng
authors.initials: WS
authors.lastname: Xiang
authors.forename: Ji-Dong
authors.initials: JD
authors.lastname: Wang
authors.forename: Xiang-Jing
authors.initials: XJ
authors.lastname: Wang
authors.forename: Ji
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D005285:Fermentation; D006801:Humans; D008969:Molecular Sequence Data; D025282:Mycelium / Q000235:genetics / Q000254:growth & development / Q000378:metabolism; D010456:Peptides, Cyclic / Q000096:biosynthesis / Q000737:chemistry* / Q000494:pharmacology; D013302:Streptomyces / Q000235:genetics / Q000254:growth & development / Q000378:metabolism*
chemical_list: D000970:Antineoplastic Agents; D010456:Peptides, Cyclic; C544879:bingchamide A; C544880:bingchamide B