title: Recent progress in the biology and physiology of sirtuins.
abstract: The sirtuins are a highly conserved family of NAD(+)-dependent enzymes that regulate lifespan in lower organisms. Recently, the mammalian sirtuins have been connected to an ever widening circle of activities that encompass cellular stress resistance, genomic stability, tumorigenesis and energy metabolism. Here we review the recent progress in sirtuin biology, the role these proteins have in various age-related diseases and the tantalizing notion that the activity of this family of enzymes somehow regulates how long we live.
authors.affiliation: Translational Medicine Branch, National Heart Lung and Blood Institute, US National Institutes of Health, Bethesda, Maryland 20892, USA.
authors.forename: Toren
authors.initials: T
authors.lastname: Finkel
authors.forename: Chu-Xia
authors.initials: CX
authors.lastname: Deng
authors.forename: Raul
authors.initials: R
authors.lastname: Mostoslavsky
mesh_terms: D000375:Aging / Q000502:physiology; D000818:Animals; D004260:DNA Repair / Q000502:physiology; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D008136:Longevity / Q000502:physiology; D037761:Sirtuins / Q000378:metabolism / Q000502:physiology*; D013312:Stress, Physiological / Q000502:physiology
chemical_list: D037761:Sirtuins