title: Enzyme promotes the hydrogelation from a hydrophobic small molecule.
abstract: We report in this paper that an enzymatic reaction can be used as the sole mechanism for forming supramolecular hydrogels that have good stability in aqueous solutions at room temperature. The gels are two-component hydrogels that are mainly formed by hydrophobic compound 2 and doped with hydrophilic compound 1. They were formed by an enzymatic process that produces hydrophobic 2 in homogeneous modes and assists the formation of three-dimensional networks. We have characterized the morphologies of the gels with scanning electron microscopy and dark-field transmission electron microscopy, collected fluorescence data to monitor the gelation process, and proposed a possible mechanism to explain the formation of the gels.
authors.affiliation: Key Laboratory of Bioactive Materials, Ministry of Education, Tianjin 300071, PR China.
authors.forename: Jie
authors.initials: J
authors.lastname: Gao
authors.forename: Huaimin
authors.initials: H
authors.lastname: Wang
authors.forename: Ling
authors.initials: L
authors.lastname: Wang
authors.forename: Jingyu
authors.initials: J
authors.lastname: Wang
authors.forename: Deling
authors.initials: D
authors.lastname: Kong
authors.forename: Zhimou
authors.initials: Z
authors.lastname: Yang
mesh_terms: D055162:Biocatalysis; D020100:Hydrogels / Q000737:chemistry* / Q000378:metabolism*; D057927:Hydrophobic and Hydrophilic Interactions; D008855:Microscopy, Electron, Scanning; D008856:Microscopy, Fluorescence; D008958:Models, Molecular; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism*
chemical_list: D020100:Hydrogels; D010744:Phosphoric Monoester Hydrolases