title: Dynamic Causal Modeling applied to fMRI data shows high reliability.
abstract: Sensitivity, specificity, and reproducibility are vital to interpret neuroscientific results from functional magnetic resonance imaging (fMRI) experiments. Here we examine the scan-rescan reliability of the percent signal change (PSC) and parameters estimated using Dynamic Causal Modeling (DCM) in scans taken in the same scan session, less than 5 min apart. We find fair to good reliability of PSC in regions that are involved with the task, and fair to excellent reliability with DCM. Also, the DCM analysis uncovers group differences that were not present in the analysis of PSC, which implies that DCM may be more sensitive to the nuances of signal changes in fMRI data.
authors.affiliation: Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin-Madison, USA.
authors.forename: Brianna
authors.initials: B
authors.lastname: Schuyler
authors.forename: John M
authors.initials: JM
authors.lastname: Ollinger
authors.forename: Terrence R
authors.initials: TR
authors.lastname: Oakes
authors.forename: Tom
authors.initials: T
authors.lastname: Johnstone
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Davidson
mesh_terms: D000161:Acoustic Stimulation; D000293:Adolescent; D000328:Adult; D000465:Algorithms; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D008959:Models, Neurological; D015233:Models, Statistical; D010775:Photic Stimulation; D015203:Reproducibility of Results; D055815:Young Adult