title: 18F-FDG PET for detecting metastases and synchronous primary malignancies in patients with oral and oropharyngeal cancer.
abstract: OBJECTIVE
  Assessment of the efficiency of 18F-FDG-PET (PET) for the detection of distant metastases and synchronous primary malignancies in patients with oral and oropharyngeal squamous cell cancer (OOSCC).
  
  
  METHODS
  Retrospective evaluation of PET studies of 422 patients with histologically confirmed OOSCC. 99 patients (23.5%) demonstrated a suspect distant finding of whom 84 could be interdisciplinary evaluated and consecutively confirmed or refuted by other diagnostic modalities or biopsy.
  
  
  RESULTS
  In 74 of 80 evaluable cases, PET showed the primary tumour (92.5%). 26/84 suspect distant lesions (31%) showed by means of PET were confirmed to be malignancies (mean SUV 3.96; range 1.4-9.37). Main sites were the lung, the upper aerodigestive tract, and the gastrointestinal system. In the other 58 cases (69%), where the suspect lesions were confirmed as benign, mean SUV was 2.65 (range 0.7-6.5) (difference statistically significant). The SUV above which every suspect finding was proven to be of malignant condition was 6.5 (specificity 100%, sensitivity 38%, accuracy 81%).
  
  
  CONCLUSIONS
  PET may have an important role in initial staging and the detection of distant metastases and synchronous primary malignancies. Setting a SUV threshold for determining malignancies can support interpretation. In borderline cases, however, interdisciplinary evaluation by means of other diagnostic modalities remains crucial.
authors.affiliation: Department of Oral and Cranio-Maxillofacial Plastic Surgery, Goethe University Medical Centre, Frankfurt am Main, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Wallowy
authors.forename: J
authors.initials: J
authors.lastname: Diener
authors.forename: F
authors.initials: F
authors.lastname: Grünwald
authors.forename: A F
authors.initials: AF
authors.lastname: Kovács
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D009362:Neoplasm Metastasis / Q000000981:diagnostic imaging*; D009367:Neoplasm Staging; D009959:Oropharyngeal Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D010157:Palatal Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology; D049268:Positron-Emission Tomography; D012189:Retrospective Studies; D014062:Tongue Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology
chemical_list: D019788:Fluorodeoxyglucose F18