title: [Meta-analysis on the correlation of cholecystectomy or cholecystolithiasis to risk of colorectal cancer in Chinese population].
abstract: OBJECTIVE
  It is reported that the incidence of colorectal cancer is higher in patients receiving cholecystectomy (CHE) than in those who did not. However, the correlation of CHE and cholecystolithiasis (CHO) to colorectal cancer is unclear. This study was to investigate the correlation of CHE or CHO to risk of colorectal cancer in Chinese population.
  
  
  METHODS
  A meta-analysis was conducted according to the guidelines set forth by the meta-analysis of observational studies in epidemiology (MOOSE statement). A manual and computer search of literature was performed. Included literatures were evaluated using the Newcastle-Ottawa Scale. Original data were extracted, pooled odd ratio (OR) and 95% confidence intervals (Cl) were calculated using revman 5.0.
  
  
  RESULTS
  In total 26 studies were included. The pooled OR between CHO or CHE, CHE alone, CHO alone and colorectal cancer were 3.00 (95%IC 2.30-3.91), 2.85 (95%IC 2.13-3.81) and 2.68 (95%IC 1.93-3.72), respectively. Sub-group analysis in sex and position of tumors revealed obvious correlation of CHE or CHO to colorectal cancer except for the men's subgroup.
  
  
  CONCLUSIONS
  CHE or CHO may be associated with colorectal cancer in Chinese population.
authors.affiliation: Department of Gastrointestinal Surgery, Xinjiang Medical University, Urumqi, Xinjiang, People's Republic of China.
authors.forename: Yi-Ke
authors.initials: YK
authors.lastname: Xu
authors.forename: Feng-Lan
authors.initials: FL
authors.lastname: Zhang
authors.forename: Tao
authors.initials: T
authors.lastname: Feng
authors.forename: Jin
authors.initials: J
authors.lastname: Li
authors.forename: Yun-Hai
authors.initials: YH
authors.lastname: Wang
mesh_terms: D002681:China; D002763:Cholecystectomy / Q000009:adverse effects*; D041761:Cholecystolithiasis / Q000150:complications / Q000601:surgery*; D015179:Colorectal Neoplasms / Q000209:etiology*; D016001:Confidence Intervals; D016206:Databases, Bibliographic; D005260:Female; D006801:Humans; D008297:Male; D016017:Odds Ratio; D012307:Risk Factors; D012737:Sex Factors