title: Prevalence and clinical significance of medication discrepancies at pediatric hospital admission.
abstract: OBJECTIVE
  To quantify admission medication discrepancies in a tertiary-care, general pediatric population, to describe their clinical importance and associated factors, and to assess a screening approach to pharmacist involvement.
  
  
  METHODS
  A total of 272 patients were studied prospectively at hospital admission. The study pharmacist performed a medication history and compared it to physicians' admission medication orders. Discrepancies between the 2 were coded as intentional but undocumented or unintentional. Unintentional discrepancies were rated for potential to cause harm by 3 physicians. Additional data collected included patients' reason for admission and presence of chronic conditions, whether physicians used a medication reconciliation form, the characteristics of patients' home medication regimen, and the time required to perform a pharmacist history and reconciliation. Interrater reliability and associations between baseline characteristics and discrepancy rates were explored.
  
  
  RESULTS
  Eighty patients (30%) had at least one undocumented intentional discrepancy (range, 0-7). At least one unintentional discrepancy (range, 0-9) was found in 59 patients (22%). Of the unintentional discrepancies, 23% had moderate and 6% had severe potential to cause discomfort or deterioration. Ratings were similar among the 3 physicians. Characteristics associated with higher risk of clinically important discrepancies were: use of the medication reconciliation form, > or =4 prescription medications, and antiepileptic drug use. Logistic regression revealed that only the variable > or =4 medications was independently associated with clinically important discrepancies.
  
  
  CONCLUSIONS
  Admission medication errors are common in this tertiary-care, general pediatric population, and nearly a third represent potential adverse events. The use of a medication reconciliation form by physicians without pharmacist involvement does not appear to reduce errors. A cutoff of > or =4 prescription medications is highly sensitive for identifying patients at risk of clinically important discrepancies.
authors.affiliation: Division of Pediatric Medicine, Hospital for Sick Children, Toronto, Ontario, M5G 1X8, Canada. trey.coffey@sickkids.ca
authors.forename: Maitreya
authors.initials: M
authors.lastname: Coffey
authors.forename: Lynn
authors.initials: L
authors.lastname: Mack
authors.forename: Kim
authors.initials: K
authors.lastname: Streitenberger
authors.forename: Teresa
authors.initials: T
authors.lastname: Bishara
authors.forename: Laura
authors.initials: L
authors.lastname: De Faveri
authors.forename: Anne
authors.initials: A
authors.lastname: Matlow
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D006776:Hospitals, Pediatric; D006801:Humans; D008487:Medical History Taking; D008508:Medication Errors / Q000009:adverse effects* / Q000706:statistics & numerical data*; D010343:Patient Admission; D015995:Prevalence; D015203:Reproducibility of Results; D012189:Retrospective Studies; D018570:Risk Assessment