[The expressions of PPAR-gamma, COX-2 in the lesions of patients with condyloma acuminatum and bowenoid papulosis].
OBJECTIVE
To investigate the expression of PPAR-gamma, COX-2 in the skin lesion of condyloma acuminatum and bowenoid papulosis.


METHODS
The expression levels of PPAR-gamma, COX-2 were measured by immunohistochemistry in 17 cases of condyloma acuminatum, 17 cases of bowenoid papulosis, as well as 17 cases of normal foreskin lesions.


RESULTS
The immunohistochemical study showed that PPAR-gamma and COX-2 weakly expressed in normal foreskin, but overexepressed in the skin lesions of both condyloma acuminatum and bowenoid papulosis (P<0.01). There was straight linear correlation between the expressions of PPAR-gamma and COX-2 not only in condyloma acuminatum (r=0.505, P=0.038) but also in bowenoid papulosis (r=0.562, P=0.019).


CONCLUSIONS
PPAR-gamma and COX-2 may have important roles in proliferative dermatosis associated with human papilloma virus.
Ni
Jun
J
Department of Dermatology, West China Fouth Hospital, Sichuan University, Chengdu 610041, China.
Zhang
Yi-zhi
YZ
Xue
Si-liang
SL
D000328:Adult; D000368:Aged; D001913:Bowen's Disease / Q000378:metabolism* / Q000821:virology; D003218:Condylomata Acuminata / Q000378:metabolism* / Q000821:virology; D051546:Cyclooxygenase 2 / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D047495:PPAR gamma / Q000378:metabolism*; D030361:Papillomavirus Infections / Q000378:metabolism* / Q000473:pathology; D012867:Skin / Q000378:metabolism; D055815:Young Adult
D047495:PPAR gamma; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human