Antidiabetic effects of Artemisia sphaerocephala Krasch. gum, a novel food additive in China, on streptozotocin-induced type 2 diabetic rats.
OBJECTIVE
Since ancient times, practicians of traditional Chinese medicine have discovered that Artemisia sphaerocephala Krasch. (Asteraceae) seed powder was useful for the treatment of diabetes. Artemisia sphaerocephala Krasch. gum (ASK gum), which is extracted from seed powder of the plant, is a novel food additive favored by the food industry in China. The objective of this study was to determine the antidiabetic function of ASK gum on type 2 diabetes.


METHODS
Type 2 diabetic rat model was induced with high fat diet and low dose of streptozotocin (STZ). The effects of ASK gum on hyperglycemia, hyperlipemia, insulin resistance, and liver fat accumulation in type 2 diabetic rats were evaluated. The results were compared to those of normal rats and diabetic rats treated with metformin.


RESULTS
The addition of ASK gum to the rats' food supply significantly lowered fasting blood glucose, glycated serum protein, serum cholesterol, and serum triglyceride in type 2 diabetic rats, and significantly elevated liver glucokinase, liver glycogen, and serum high density protein cholesterol in the diabetic rats. ASK gum significantly reduced insulin resistance and liver fat accumulation of type 2 diabetes.


CONCLUSIONS
Artemisia sphaerocephala Krasch. gum can alleviate hyperglycemia, hyperlipemia and insulin resistance of type 2 diabetes.
Xing
Xiao-Hui
XH
Northwest A & F University, College of Food Science and Engineering, No. 28 Xinong Road, Yangling, Shaanxi 712100, China.
Zhang
Zheng-Mao
ZM
Hu
Xin-Zhong
XZ
Wu
Rui-Qin
RQ
Xu
Chao
C
D000818:Animals; D019306:Artemisia / Q000378:metabolism*; D001786:Blood Glucose / Q000032:analysis; D002681:China; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000178:diet therapy* / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004435:Eating; D005215:Fasting; D005260:Female; D005503:Food Additives / Q000008:administration & dosage*; D005941:Glucokinase / Q000378:metabolism; D017127:Glycation End Products, Advanced / Q000097:blood; D007333:Insulin Resistance; D008099:Liver / Q000201:enzymology / Q000378:metabolism; D008112:Liver Glycogen / Q000378:metabolism; D008687:Metformin / Q000627:therapeutic use; D008517:Phytotherapy / Q000379:methods*; D053149:Plant Gums / Q000378:metabolism; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013311:Streptozocin / Q000009:adverse effects*; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D008076:Cholesterol, HDL; D005503:Food Additives; D017127:Glycation End Products, Advanced; D008112:Liver Glycogen; D053149:Plant Gums; D014280:Triglycerides; D013311:Streptozocin; D008687:Metformin; D002784:Cholesterol; D005941:Glucokinase