Xanthoradones, new potentiators of imipenem activity against methicillin-resistant Staphylococcus aureus, produced by Penicillium radicum FKI-3765-2 II. Structure elucidation.
The structures of xanthoradones A and B, new potentiators of imipenem activity against methicillin-resistant Staphylococcus aureus produced by Penicillium radicum FKI-3765-2, were elucidated by spectroscopic studies, including various NMR experiments. These compounds have an asymmetric biaryl skeleton, which contains dihydronaphthopyranone and naphthoquinone moieties.
Yamazaki
Hiroyuki
H
Graduate School of Pharmaceutical Sciences, Kitasato University, Minato-ku, Tokyo, Japan.
Omura
Satoshi
S
Tomoda
Hiroshi
H
D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000737:chemistry / Q000494:pharmacology*; D004357:Drug Synergism; D015378:Imipenem / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects*; D008968:Molecular Conformation; D010407:Penicillium / Q000378:metabolism*; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D000900:Anti-Bacterial Agents; C544254:xanthoradone A; C544255:xanthoradone B; D015378:Imipenem