title: Polyelectrolyte-coated alginate microspheres as drug delivery carriers for dexamethasone release.
abstract: Alginate microspheres loaded with dexamethasone were prepared by the droplet generator technique. Important parameters affecting drug release, including initial drug content, the type of polyelectrolyte coating, and a combination of different ratios of coated and uncoated microspheres were investigated to achieve in vitro dexamethasone delivery with approximately zero order release kinetics, releasing up to 100% of entrapped drug within 1 month, wherein dexamethasone released at a steady rate of 4.83 microg/day after an initial burst release period. These findings imply that these polyelectrolyte-coated alginate microspheres show promise as release systems to improve biocompatibility and prolong lifetime of implantable glucose sensors.
authors.affiliation: School of Biosciences and Bioengineering, IIT Bombay, Powai, Mumbai, India.
authors.forename: R D
authors.initials: RD
authors.lastname: Jayant
authors.forename: M J
authors.initials: MJ
authors.lastname: McShane
authors.forename: R
authors.initials: R
authors.lastname: Srivastava
mesh_terms: D000464:Alginates / Q000008:administration & dosage* / Q000493:pharmacokinetics; D000818:Animals; D002478:Cells, Cultured; D003907:Dexamethasone / Q000008:administration & dosage* / Q000493:pharmacokinetics; D004337:Drug Carriers / Q000008:administration & dosage* / Q000493:pharmacokinetics; D016503:Drug Delivery Systems / Q000379:methods*; D020723:Glucuronic Acid / Q000008:administration & dosage / Q000493:pharmacokinetics; D006603:Hexuronic Acids / Q000008:administration & dosage / Q000493:pharmacokinetics; D051379:Mice; D008863:Microspheres; D010316:Particle Size; D011108:Polymers / Q000008:administration & dosage* / Q000493:pharmacokinetics
chemical_list: D000464:Alginates; D004337:Drug Carriers; D006603:Hexuronic Acids; D011108:Polymers; C002189:polyelectrolyte 60; D003907:Dexamethasone; D020723:Glucuronic Acid