[Effect of qianjin huanglian pill on kidney in insulin resistance mice].
OBJECTIVE
To investigate the effect of qianjin huanglian pill on kidney in monosodium L-glutamate (MSG)-treated insulin resistance (IR) mice.


METHODS
The ameliorative effect of qianjin huanglian pill on IR in MSG mice was evaluated in comparison with rosiglitazone (Ros). The fasting serum glucose, fasting serum insulin, insulin sensitivity index, urinary albumin excretion, glomerular diameter and pathological changes of kidney were investigated in the evaluation.


RESULTS
After 2 weeks of qianjin huanglian pill treatment, the urinary albumin excretion (UAE) was reduced in low-dose group (P < 0.05) as compared with the model group. After 4 weeks of qianjin huanglian pill treatment, the fasting serum glucose was reduced in high-dose group (P < 0.001 compared with the model group). ISI of mice was ameliorated in high-dose group (P < 0.05 compared with the model group). The glomerular diameter was decreased, the hyperplasia of glomerulus was ameliorated in high-dose and low-dose groups (P < 0.01 compared with model group).


CONCLUSIONS
In MSG mice, we found qianjin huanglian pill could increase insulin sensitivity, decrease the urinary albumin excretion, ameliorate the pathological changes of kidney due to insulin resistance.
Tian
Aiping
A
Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beqing 100021, China. aipingtian@126.com
Zou
Chenhui
C
Sun
Sujuan
S
Chen
Yueteng
Y
Guo
Saishan
S
Shen
Zhufang
Z
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002626:Chemistry, Pharmaceutical; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D007333:Insulin Resistance; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D007678:Kidney Glomerulus / Q000187:drug effects / Q000473:pathology; D008297:Male; D051379:Mice; D012970:Sodium Glutamate / Q000633:toxicity
D001786:Blood Glucose; D004365:Drugs, Chinese Herbal; C543005:qianjin huanglian; D012970:Sodium Glutamate