title: Multidetector CT in the evaluation of retroperitoneal fat tissue infiltration in ductal adenocarcinoma of the pancreatic head: correlation with histopathological findings.
abstract: BACKGROUND
  Neoplastic infiltration of the retroportal fat tissue is a critical parameter in tumor staging and in surgical planning because it frequently represents a site of persistence and recurrence of disease.
  
  
  METHODS
  We evaluated 64 patients affected by ductal adenocarcinoma of the pancreatic head/uncinate process, submitted to curative surgery. Suspicion of infiltration (micro or macroinfiltration) of the retroportal margin arose at MDCT in cases of obliteration, irregularity, or abnormal density of the fatty layer localized between the medial surface of the pancreatic head/uncinate process and the mesenteric artery.
  
  
  RESULTS
  CT suggested the infiltration of the retroportal tissue in 27 cases (10 microinfiltration, 17 macroinfiltration). At histopathology, the presence of infiltration was confirmed in 21/27 (78%) cases. In all CT cases of microinfiltration, the retroperitoneal resection margin was not infiltrated, while all cases (6) with infiltration of the retroperitoneal margin were macroinfiltrated at CT. The sensitivity of CT was 80%, specificity of 84% with an overall diagnostic accuracy of 82%.
  
  
  CONCLUSIONS
  MDCT is accurate in the assessment of the neoplastic infiltration of the retroportal fat tissue.
authors.affiliation: Division of Diagnostic and Interventional Radiology, University of Pisa, Via Roma, 67, Pisa, PI 56123, Italy. s.mazzeo@med.unipi.it
authors.forename: Salvatore
authors.initials: S
authors.lastname: Mazzeo
authors.forename: Carla
authors.initials: C
authors.lastname: Cappelli
authors.forename: Valentina
authors.initials: V
authors.lastname: Battaglia
authors.forename: Davide
authors.initials: D
authors.lastname: Caramella
authors.forename: Gabriele
authors.initials: G
authors.lastname: Caproni
authors.forename: Benedetta
authors.initials: B
authors.lastname: Pontillo Contillo
authors.forename: Marco
authors.initials: M
authors.lastname: Del Chiaro
authors.forename: Ugo
authors.initials: U
authors.lastname: Boggi
authors.forename: Niccola
authors.initials: N
authors.lastname: Funel
authors.forename: Luca
authors.initials: L
authors.lastname: Pollina
authors.forename: Daniela
authors.initials: D
authors.lastname: Campani
authors.forename: Franco
authors.initials: F
authors.lastname: Mosca
authors.forename: Carlo
authors.initials: C
authors.lastname: Bartolozzi
mesh_terms: D021441:Carcinoma, Pancreatic Ductal / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D050152:Intra-Abdominal Fat / Q000000981:diagnostic imaging* / Q000473:pathology; D009361:Neoplasm Invasiveness; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D014057:Tomography, X-Ray Computed