Molecularly imprinted polymers--tyrosinase mimics.
Synthetic polymers mimicking the enzyme tyrosinase have been prepared by the molecular imprinting of a complex between Cu (II) and catechol and ethyl ester of urocanic acid in an ethylene glycol dimethacrylate copolymer. Optimised polymer systems demonstrated catalysis, Michaelis-Menten kinetics and competitive inhibition similar to those of mushroom tyrosinase. The polymers benefited from superior chemical and mechanical stability in comparison with natural enzyme.
Piletsky
S A
SA
Institute of Bioscience and Technology, Cranfield University, UK.
Nicholls
I A
IA
Rozhko
M I
MI
Sergeyeva
T A
TA
Piletska
E V
EV
El Skaya
A V
AV
Karube
I
I
D003432:Cross-Linking Reagents / Q000138:chemical synthesis* / Q000737:chemistry; D054802:Molecular Imprinting; D018716:Molecular Mimicry; D015394:Molecular Structure; D014442:Monophenol Monooxygenase / Q000737:chemistry*; D010084:Oxidation-Reduction; D044367:Phase Transition; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry
D003432:Cross-Linking Reagents; D011108:Polymers; D014442:Monophenol Monooxygenase