title: Does the DRB1*1501 allele confer more severe and faster progression in primary progressive multiple sclerosis patients? HLA in primary progressive multiple sclerosis.
abstract: The effect of HLA alleles on the outcome of multiple sclerosis (MS) has been widely investigated; however, results are conflicting and no consistent correlation has been established. This study evaluated the association between the HLA DR2 haplotype in patients with primary progressive MS (PPMS) and the effect of alleles on progression. An association was found between PPMS and the DR2 and DRB1*1501 and DQB1*0602 alleles. Severe morbidity was found in DRB1*1501-positive PPMS patients. This exploratory study raises new hypotheses for future research and emphasizes the need to investigate possible candidate genes other than HLA that may contribute towards heterogeneity in the course of the disease.
authors.affiliation: Federal University of the State of Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: Claudia Cristina Ferreira
authors.initials: CC
authors.lastname: Vasconcelos
authors.forename: Oscar
authors.initials: O
authors.lastname: Fernández
authors.forename: Laura
authors.initials: L
authors.lastname: Leyva
authors.forename: Luiz Claudio Santos
authors.initials: LC
authors.lastname: Thuler
authors.forename: Regina Maria Papais
authors.initials: RM
authors.lastname: Alvarenga
mesh_terms: D000328:Adult; D001741:Black or African American; D000483:Alleles; D018450:Disease Progression; D005260:Female; D006683:HLA-DQ Antigens / Q000235:genetics* / Q000276:immunology; D059866:HLA-DQ beta-Chains; D015802:HLA-DR2 Antigen / Q000235:genetics* / Q000276:immunology; D006239:Haplotypes; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics* / Q000276:immunology; D008875:Middle Aged; D020528:Multiple Sclerosis, Chronic Progressive / Q000208:ethnology / Q000235:genetics* / Q000276:immunology*; D009419:Nerve Tissue Proteins / Q000235:genetics* / Q000276:immunology; D016601:RNA-Binding Proteins / Q000235:genetics* / Q000276:immunology; D012720:Severity of Illness Index; D044465:White People
chemical_list: D006683:HLA-DQ Antigens; D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen; D015802:HLA-DR2 Antigen; D008562:Membrane Glycoproteins; D009419:Nerve Tissue Proteins; C467044:RBM45 protein, human; D016601:RNA-Binding Proteins