title: [Oxaliplatin combined with capecitabine as first-line chemotherapy for patients with advanced gastric cancer].
abstract: OBJECTIVE
  Combination therapy of oxaliplatin and capecitabine has certain effects on advanced gastric cancer (AGC). This study was to investigate the efficacy and safety of oxaliplatin in combination with capecitabine as first-line chemotherapy for AGC patients.
  
  
  METHODS
  Thirty-three chemotherapy-naive patients with AGC were entered into this study. They received 2 h intravenous infusion of oxaliplatin 130 mg/m2 on day 1 and oral administration of capecitabine 2000 mg/m2, given in two daily doses, on days 1-14 (XELOX regimen). The regimen was repeated every 21 days. A maximum of eight cycles were given.
  
  
  RESULTS
  Thirty-three patients completed 159 cycles of chemotherapy with a median number of five cycles. Thirty-one patients were evaluable for efficacy. The response rate was 54.8% [95% confidence interval (CI): 37.3%-72.3%], with one complete response (3.2%), 16 partial responses (51.6%), eight stable diseases (25.8%), and six progressions (19.4%). At a mean follow-up of 10.5 months, the median time to progression and overall survival were 5.9 (95% CI: 4.7-7.1) and 10.4 months (95% CI: 7.9-12.9), respectively. The most common adverse events were myelosuppression, peripheral neuropathy, diarrhea, nausea/vomiting, and hand-foot syndrome.
  
  
  CONCLUSIONS
  XELOX is an effective and well-tolerated first-line chemotherapy regimen for patients with AGC.
authors.affiliation: Department of Internal Medicine, Shandong Tumor Hospital and Institute, Jinan, Shandong, 250117, PR China.
authors.forename: Ning-Ning
authors.initials: NN
authors.lastname: Dong
authors.forename: Ming-Yu
authors.initials: MY
authors.lastname: Wang
authors.forename: Qiong
authors.initials: Q
authors.lastname: Zhang
authors.forename: Zhi-Fang
authors.initials: ZF
authors.lastname: Liu
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology / Q000556:secondary; D002288:Adenocarcinoma, Mucinous / Q000188:drug therapy / Q000473:pathology / Q000556:secondary; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D000069287:Capecitabine; D018279:Carcinoma, Signet Ring Cell / Q000188:drug therapy / Q000473:pathology / Q000556:secondary; D003841:Deoxycytidine / Q000009:adverse effects / Q000031:analogs & derivatives / Q000627:therapeutic use; D003967:Diarrhea / Q000139:chemically induced; D018450:Disease Progression; D005260:Female; D005472:Fluorouracil / Q000009:adverse effects / Q000031:analogs & derivatives / Q000627:therapeutic use; D005500:Follow-Up Studies; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy / Q000556:secondary; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009503:Neutropenia / Q000139:chemically induced; D010071:Oxaloacetates; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced; D012074:Remission Induction; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology; D015996:Survival Rate
chemical_list: D010071:Oxaloacetates; D003841:Deoxycytidine; D000069287:Capecitabine; D005472:Fluorouracil