title: Different functional basal ganglia subcircuits associated with anti-akinetic and dyskinesiogenic effects of antiparkinsonian therapies.
abstract: Subthalamic nucleus high frequency stimulation (STN-HFS) efficiently alleviates L-DOPA-sensitive parkinsonian motor symptoms, but has no direct beneficial action on L-DOPA-induced dyskinesias (LID). Here, we provide evidence that anti-akinetic STN-HFS or dyskinesiogenic L-DOPA similarly reversed the dopamine lesion-induced increases in gene expression of cytochrome oxidase subunit I (CoI), a metabolic marker of neuronal activity, in the globus pallidus, STN and substantia nigra pars reticulata (SNr) in rats. In contrast, in entopeduncular nucleus (EP), STN-HFS did not modify the lesion-induced increase in CoI mRNA levels, whereas L-DOPA induced a marked decrease versus control. Combining the two treatments did not reveal significant interaction. Interestingly, CoI gene expression in EP but not in SNr was inversely correlated with striatal preprodynorphin mRNA level, a LID marker. This work suggests the existence of two functional basal ganglia subcircuits: the one, including STN and SNr, involved in antiparkinsonian action, and the other, including EP, preferentially involved in LID.
authors.affiliation: Team Cellular Interactions, Neurodegeneration and Neuroplasticity, Developmental Biology Institute of Marseille-Luminy, UMR 6216 CNRS-Université de Méditerranée, Marseille, France.
authors.forename: Emilie
authors.initials: E
authors.lastname: Lacombe
authors.forename: Vitaly
authors.initials: V
authors.lastname: Khaindrava
authors.forename: Christophe
authors.initials: C
authors.lastname: Melon
authors.forename: Abid
authors.initials: A
authors.lastname: Oueslati
authors.forename: Lydia
authors.initials: L
authors.lastname: Kerkerian-Le Goff
authors.forename: Pascal
authors.initials: P
authors.lastname: Salin
mesh_terms: D000818:Animals; D000978:Antiparkinson Agents / Q000009:adverse effects* / Q000494:pharmacology*; D001479:Basal Ganglia / Q000187:drug effects / Q000473:pathology*; D004195:Disease Models, Animal; D004399:Dynorphins / Q000235:genetics / Q000378:metabolism; D004409:Dyskinesia, Drug-Induced / Q000209:etiology / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D004558:Electric Stimulation / Q000379:methods; D004567:Electrodes, Implanted; D003576:Electron Transport Complex IV / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation / Q000187:drug effects; D007980:Levodopa / Q000009:adverse effects / Q000494:pharmacology*; D008297:Male; D009415:Nerve Net / Q000187:drug effects / Q000473:pathology*; D016627:Oxidopamine / Q000009:adverse effects / Q000494:pharmacology; D020734:Parkinsonian Disorders / Q000139:chemically induced / Q000473:pathology* / Q000628:therapy; D011498:Protein Precursors / Q000235:genetics / Q000378:metabolism; D021122:Protein Subunits / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000978:Antiparkinson Agents; D011498:Protein Precursors; D021122:Protein Subunits; D012333:RNA, Messenger; C036448:pre-prodynorphin; D007980:Levodopa; D004399:Dynorphins; D016627:Oxidopamine; D003576:Electron Transport Complex IV