title: Novel mannosyl derivatives of peptidoglycan monomer: Synthesis and biological evaluation of immunomodulatory properties.
abstract: The aim of this work was to prepare mannosyl derivatives of peptidoglycan monomer (PGM, beta-d-GlcNAc-(1-->4)-d-MurNAc-l-Ala-d-isoGln-mesoDAP(epsilonNH(2))-d-Ala-d-Ala) in order to study the effects of mannosylation on adjuvant (immunostimulating) activity. Novel Man-OCH(2)CH(CH(3))CO-PGM isomers were substrates for N-acetylmuramyl-l-alanine amidase, like the parent PGM molecule. Adjuvant activity of Man-OCH(2)CH(CH(3))CO-PGM was tested in the mouse model using ovalbumin as an antigen.
authors.affiliation: Department of Chemistry, University of Zagreb, Croatia.
authors.forename: Rosana
authors.initials: R
authors.lastname: Ribić
authors.forename: Lidija
authors.initials: L
authors.lastname: Habjanec
authors.forename: Marija
authors.initials: M
authors.lastname: Brgles
authors.forename: Srdanka
authors.initials: S
authors.lastname: Tomić
authors.forename: Jelka
authors.initials: J
authors.lastname: Tomasić
mesh_terms: D000276:Adjuvants, Immunologic / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D005260:Female; D008358:Mannose / Q000737:chemistry*; D051379:Mice; D010047:Ovalbumin / Q000276:immunology; D010457:Peptidoglycan / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000276:Adjuvants, Immunologic; D010457:Peptidoglycan; D010047:Ovalbumin; D008358:Mannose