[The expression and significance of TGF-beta 1 and its receptors in infertile women's fimbriae tubes with adhesions and atresias].
OBJECTIVE
To profile the expression of transforming growth factor-beta1 (TGF-beta1) and its receptors (TGF-beta R1 and TGF-beta R2) in human fimbriae tubes to valuate the role of TGF-beta 1 signal system in adhesions and atresias formation of infertile women's fimbriae tubes.


METHODS
The expressions of TGF-beta 1 and its receptors (TGF-beta R1 and TGF-beta R2) in fimbriae tubes were measured by immunohistochemical SP methods in 30 human fimbriae tube with adhesions and 15 cases without adhesions. The average integrated optical density (IOD) value of positive staining was tested by Image pro-plus 6.0 software. The results were analyzed with independ-samples T test and Pearson correlation.


RESULTS
TGF-beta 1, TGF-beta R1 and TGF-beta R2 chiefly expressed in the epithelial cells, also expressed in the vascular endothelial cells and fibroblasts. Compared with human fimbriae tubes without adhesions or atresias, the expression of these three molecules all increased significantly in adhesion cases (P<0.05). In adhesion group, there was a positive correlation between TGF-beta 1 and TGF-beta R1, TGF-beta 1 and TGF-beta R2 (P<0.05), but no correlation between TGF-beta R1 and TGF-beta R2 (P<0.05), while there was no correlation among these three factors in control group.


CONCLUSIONS
TGF-beta 1 signal system may be an important ring-joint in adhesions formation of human fimbriae tube.
Sun
Ying
Y
Department of Gynecology, West China Second Hospital, Sichuan University, Chengdu 610041, China.
Zhang
Dan
D
Wang
Cheng-fang
CF
Hu
Shi-wan
SW
Lan
Zhen
Z
D000328:Adult; D005184:Fallopian Tube Diseases / Q000150:complications / Q000378:metabolism*; D005187:Fallopian Tubes / Q000378:metabolism; D005260:Female; D020869:Gene Expression Profiling; D006801:Humans; D007247:Infertility, Female / Q000209:etiology / Q000378:metabolism*; D011247:Pregnancy; D018125:Receptors, Transforming Growth Factor beta / Q000378:metabolism*; D000267:Tissue Adhesions / Q000378:metabolism; D053773:Transforming Growth Factor beta1 / Q000378:metabolism*; D055815:Young Adult
D018125:Receptors, Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1