Design of selective Cathepsin inhibitors.
A number of molecular recognition features have been exploited in structure-based design of selective Cathepsin inhibitors.
Bethel
Paul A
PA
RIRA, AstraZeneca, Mereside, Alderley Park, Macclesfield SK10 4TG, UK.
Gerhardt
Stefan
S
Jones
Emma V
EV
Kenny
Peter W
PW
Karoutchi
Galith I
GI
Morley
Andrew D
AD
Oldham
Keith
K
Rankine
Neil
N
Augustin
Martin
M
Krapp
Stephan
S
Simader
Hannes
H
Steinbacher
Stefan
S
D002403:Cathepsins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D003198:Computer Simulation; D018360:Crystallography, X-Ray; D015195:Drug Design; D011480:Protease Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D011480:Protease Inhibitors; D002403:Cathepsins