title: Diagnostic test validation: cochlear hydrops analysis masking procedure in Ménière's disease.
abstract: OBJECTIVE
  To determine the diagnostic value of the cochlear hydrops analysis masking procedure (CHAMP) in patients with definite Ménière's disease.
  
  
  METHODS
  Prospective validation study for a diagnostic test, study phase 2.
  
  
  METHODS
  Tertiary referral centers.
  
  
  METHODS
  Subjects with definite Ménière's disease (Group 1), differential diagnosis (Group 2: another audiovestibular diseases or neurologic disorders), and normal hearing (Group 3) were included. Sample sizes were calculated.
  
  
  METHODS
  Study test (CHAMP) was compared with the current clinical criterion standard described by the guidelines of the American Academy of Otolaryngology-Head and Neck Surgery.
  
  
  METHODS
  Sensitivity, specificity, and other indicators of diagnostic validation.
  
  
  RESULTS
  One hundred ten cases completed the follow-up, and their results are presented. Sensitivity at 31.3% and specificity at 100% were found in subjects with definite Ménière's disease, features that are more helpful in confirming the diagnosis than in rejecting it. Group 1 showed significantly shorter latency delays than Groups 2 and 3 (p < 0.001).
  
  
  CONCLUSIONS
  If definite Ménière's disease is suspected, an abnormal result confirms the diagnosis; however, a normal result does not rule out the Ménière's disease diagnosis.
authors.affiliation: Universidad Militar Nueva Granada, Otolaryngology Department, Hospital Universitario Clínica San Rafael, Bogotá, Colombia. otoleor@gmail.com
authors.forename: Leonardo Elías
authors.initials: LE
authors.lastname: Ordóñez-Ordóñez
authors.forename: Eveling
authors.initials: E
authors.lastname: Rojas-Roncancio
authors.forename: Víctor
authors.initials: V
authors.lastname: Hernández-Alarcón
authors.forename: Rafael
authors.initials: R
authors.lastname: Jaramillo-Safón
authors.forename: Jose
authors.initials: J
authors.lastname: Prieto-Rivera
authors.forename: Jose
authors.initials: J
authors.lastname: Guzmán-Durán
authors.forename: Jose
authors.initials: J
authors.lastname: Lora-Falquez
authors.forename: Marcela
authors.initials: M
authors.lastname: Escobar
authors.forename: Esther Sofía
authors.initials: ES
authors.lastname: Angulo-Martínez
mesh_terms: D000328:Adult; D001299:Audiometry; D015834:Cochlear Diseases / Q000175:diagnosis*; D003937:Diagnosis, Differential; D004487:Edema / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008297:Male; D008575:Meniere Disease / Q000175:diagnosis*; D008875:Middle Aged; D011446:Prospective Studies; D012015:Reference Standards; D015203:Reproducibility of Results; D018401:Sample Size