Correlation of erythrocyte fatty acid composition and dietary intakes with markers of atherosclerosis in patients with myocardial infarction.
The purpose of this study was to examine the hypothesis that erythrocytes that are low in n-3 fatty acids and high in trans-fatty acids and nutrient intakes are associated with the risk of atherosclerosis. Fifty patients with acute nonfatal myocardial infarction were recruited to measure their dietary intake, erythrocyte fatty acid composition, intima medial thickness (IMT), and the Gensini score, which are markers of atherosclerosis. Trans-oleic acid of erythrocytes was positively (P = .05) correlated with the carotid IMT. After adjusting for age, sex, and energy intake, the IMT was negatively associated with the intake of protein, fat, phosphate, zinc, vitamin B(1), vitamin B(2), vitamin B(6), niacin, linoleic acid, linolenic acid, total fatty acids, total n-3 fatty acids, and total n-6 fatty acids. The Gensini score was also negatively associated with the intake of protein, fat, phosphate, sodium, zinc, vitamin E, vitamin B(1), vitamin B(2), vitamin B(6), niacin, linolenic acid, total fatty acids, and total n-3 fatty acids. In conclusion, lower levels of trans-oleic acid (elaidic acid) in erythrocytes and higher intakes of vitamins, minerals, and n-3 fatty acids were associated with the decreased risk of atherosclerosis. However, these findings need further investigation in randomized controlled clinical trials before public health recommendations for atherosclerosis prevention can be made.
Park
Yongsoon
Y
Department of Food and Nutrition, Hanyang University, Seoul, South Korea. yongsoon@hanyang.ac.kr
Lim
Jeehyun
J
Kwon
Yongju
Y
Lee
Jaeung
J
D000367:Age Factors; D000368:Aged; D050197:Atherosclerosis / Q000175:diagnosis* / Q000517:prevention & control; D015415:Biomarkers; D002339:Carotid Arteries / Q000000981:diagnostic imaging / Q000473:pathology; D002340:Carotid Artery Diseases / Q000473:pathology; D004034:Diet Surveys; D004041:Dietary Fats; D004912:Erythrocytes / Q000737:chemistry*; D005227:Fatty Acids / Q000032:analysis*; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007723:Korea; D008297:Male; D018977:Micronutrients / Q000008:administration & dosage*; D008875:Middle Aged; D009203:Myocardial Infarction / Q000503:physiopathology*; D019301:Oleic Acid / Q000032:analysis; D009829:Oleic Acids; D012737:Sex Factors; D044242:Trans Fatty Acids / Q000008:administration & dosage; D017539:Tunica Intima / Q000473:pathology; D014463:Ultrasonography; D014815:Vitamins / Q000008:administration & dosage
D015415:Biomarkers; D004041:Dietary Fats; D005227:Fatty Acids; D015525:Fatty Acids, Omega-3; D018977:Micronutrients; D009829:Oleic Acids; D044242:Trans Fatty Acids; D014815:Vitamins; D019301:Oleic Acid; C011459:elaidic acid