Short-term antibiotics treatment in patients with nasal polyps and enterotoxins producing Staphylococcus aureus strains.
Enterotoxins produced by Staphylococcus aureus (SA) can act as super-antigens and thus influence the course of chronic rhinosinusitis with nasal polyps (NP). The aim of this study was to determine if antibiotic treatment administered after endoscopic sinus surgery (ESS) for NP can positively influence the course of the disease compared to placebo. After ESS, 23 patients who tested positive, in a perioperative culture, for SA strains producing enterotoxins A-E and TSST-1, were randomized into two groups. Group A which in addition to standard treatment received oral anti-staphylococcal antibiotics for 3 weeks. Group B received a placebo. Both groups were compared preoperatively, and at 3 and 6 months after surgery using a symptom-specific score, an endoscopic score and the SNOT-22 quality of life questionnaire. Slightly better results were achieved in patients who received antibiotic therapy. However, the differences were not statistically significant. Regardless of post-operative treatment, approximately 30% of patients had a SA-negative culture 6 months after surgery.
Schalek
Petr
P
Department of ENT FNKV, 3rd Medical Faculty of Charles University, Srobarova 50, 10034 Prague, Czech Republic. schalek@fnkv.cz
Petrás
P
P
Klement
V
V
Hahn
A
A
D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D000888:Antibodies, Anti-Idiotypic / Q000032:analysis; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D004724:Endoscopy; D004768:Enterotoxins / Q000276:immunology / Q000378:metabolism*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000601:surgery*; D013517:Otorhinolaryngologic Surgical Procedures / Q000379:methods; D011182:Postoperative Care / Q000379:methods; D011446:Prospective Studies; D012220:Rhinitis / Q000188:drug therapy* / Q000382:microbiology; D013211:Staphylococcus aureus / Q000302:isolation & purification / Q000378:metabolism*; D013530:Surgical Wound Infection / Q000188:drug therapy* / Q000382:microbiology; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D000888:Antibodies, Anti-Idiotypic; D004768:Enterotoxins; D007073:Immunoglobulin E