title: Baseline Ad5 serostatus does not predict Ad5 HIV vaccine-induced expansion of adenovirus-specific CD4+ T cells.
abstract: The mechanisms underlying possible increased HIV-1 acquisition in adenovirus 5 (Ad5)-seropositive subjects vaccinated with Ad5-HIV-1 vectors in the Merck STEP trial remain unclear. We find that Ad5 serostatus does not predict Ad5-specific CD4(+) T cell frequency, and we did not observe durable significant differences in Ad5-specific CD4(+) T cells between Ad5-seropositive and Ad5-seronegative subjects after vaccination. These findings indicate no causative role for Ad5-specific CD4(+) T cells in increasing HIV-1 susceptibility in the STEP trial.
authors.affiliation: Department of Microbiology and Center for AIDS Research, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
authors.forename: Natalie A
authors.initials: NA
authors.lastname: Hutnick
authors.forename: Diane G
authors.initials: DG
authors.lastname: Carnathan
authors.forename: Sheri A
authors.initials: SA
authors.lastname: Dubey
authors.forename: George
authors.initials: G
authors.lastname: Makedonas
authors.forename: Kara S
authors.initials: KS
authors.lastname: Cox
authors.forename: Lisa
authors.initials: L
authors.lastname: Kierstead
authors.forename: Sarah J
authors.initials: SJ
authors.lastname: Ratcliffe
authors.forename: Michael N
authors.initials: MN
authors.lastname: Robertson
authors.forename: Danilo R
authors.initials: DR
authors.lastname: Casimiro
authors.forename: Hildegund C J
authors.initials: HC
authors.lastname: Ertl
authors.forename: Michael R
authors.initials: MR
authors.lastname: Betts
mesh_terms: D016915:AIDS Vaccines / Q000276:immunology*; D000163:Acquired Immunodeficiency Syndrome / Q000097:blood / Q000175:diagnosis / Q000276:immunology / Q000628:therapy*; D000256:Adenoviridae / Q000276:immunology*; D000914:Antibodies, Viral / Q000097:blood*; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D049109:Cell Proliferation; D015497:HIV-1 / Q000276:immunology; D006801:Humans; D011379:Prognosis; D037182:T-Cell Antigen Receptor Specificity / Q000276:immunology*; D014614:Vaccines, Synthetic / Q000276:immunology
chemical_list: D016915:AIDS Vaccines; D000914:Antibodies, Viral; D014614:Vaccines, Synthetic