[Is hepatomegaly a prognosis factor of chronic myeloid leukaemia among African blacks?].
It acts of a retrospective study relating to 74 patients reached of chronic Leukaemia myeloid (LMC) over one 5 year period followed in the clinical service of hematology of the University Hospital of Yopougon (Abidjan, Ivory Coast). The splenomegaly is quasi-constant in chronic phase of the disease often associated hepatomegaly in 20.27% of the cases which constitutes a pejorative factor of the LMC. Indeed, the hyperleukocytosis of more than 300,000 white globules is correlated with the presence of hepatomegaly (p=0.0005) with risks of portal hypertension. 80% of the patients carrying the LMC with a clinical hepatomegaly in chronic phase of the disease have against an incomplete hematologic remission 20% of complete remission (P = 0.002) among patients without hepatomegaly. The strong rate of death (73.33%) recorded occurred among patients carrying a hepatomegaly against 15.25% of death without hepatomegaly (P = 0.0001). The overall rates Total survival is on average 17 months against 20 months 28 days in the event of absence of the hepatomegaly (P = 0.0001).
Nanho
D C
DC
Service d’Hématologie clinique CHU Yopougon 21 BP 632 Abidjan, Côte d’Ivoire. clotairedanho@yahoo.fr
N'Diaye
F S
FS
Tolo
A
A
Kouamenan
G S
GS
Sekongo
Y M
YM
Ayemou
R
R
Meite
D
D
Kouehion
P
P
Kouakou
B
B
Koffi
K G
KG
Sanogo
I
I
Sangare
Amadou
A
D000293:Adolescent; D000328:Adult; D044383:Black People; D002648:Child; D002675:Child, Preschool; D006529:Hepatomegaly / Q000209:etiology*; D006801:Humans; D007223:Infant; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications* / Q000401:mortality*; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D055815:Young Adult