title: A novel HLA-DRB1 allele, DRB1*1219, was identified by sequence-based typing in a Chinese leukaemia family.
abstract: A novel human leukocyte antigen DRB1 allele, DRB1*1219, has been identified in a Chinese leukaemia patient and his family by polymerase chain reaction sequence-based typing, which has one nucleotide change at position 341 (C-->T) in exon 2 from the closest matching allele DRB1*120201, resulting in an amino acid substitution from Ala-->Val at codon 85.
authors.affiliation: HLA Laboratory, Blood Center of Shandong Province, Shandong Province, China.
authors.forename: X-M
authors.initials: XM
authors.lastname: Nie
authors.forename: Y-H
authors.initials: YH
authors.lastname: Fang
authors.forename: Y
authors.initials: Y
authors.lastname: Zhang
authors.forename: W-D
authors.initials: WD
authors.lastname: He
authors.forename: C-F
authors.initials: CF
authors.lastname: Zhu
mesh_terms: D000483:Alleles; D000595:Amino Acid Sequence; D019943:Amino Acid Substitution; D001483:Base Sequence; D002681:China; D006684:HLA-DR Antigens / Q000097:blood / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D007938:Leukemia / Q000097:blood / Q000235:genetics* / Q000473:pathology*; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid; D035781:Siblings
chemical_list: D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains