Novel mannosyl derivatives of peptidoglycan monomer: Synthesis and biological evaluation of immunomodulatory properties.
The aim of this work was to prepare mannosyl derivatives of peptidoglycan monomer (PGM, beta-d-GlcNAc-(1-->4)-d-MurNAc-l-Ala-d-isoGln-mesoDAP(epsilonNH(2))-d-Ala-d-Ala) in order to study the effects of mannosylation on adjuvant (immunostimulating) activity. Novel Man-OCH(2)CH(CH(3))CO-PGM isomers were substrates for N-acetylmuramyl-l-alanine amidase, like the parent PGM molecule. Adjuvant activity of Man-OCH(2)CH(CH(3))CO-PGM was tested in the mouse model using ovalbumin as an antigen.
Ribić
Rosana
R
Department of Chemistry, University of Zagreb, Croatia.
Habjanec
Lidija
L
Brgles
Marija
M
Tomić
Srdanka
S
Tomasić
Jelka
J
D000276:Adjuvants, Immunologic / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D005260:Female; D008358:Mannose / Q000737:chemistry*; D051379:Mice; D010047:Ovalbumin / Q000276:immunology; D010457:Peptidoglycan / Q000737:chemistry* / Q000494:pharmacology
D000276:Adjuvants, Immunologic; D010457:Peptidoglycan; D010047:Ovalbumin; D008358:Mannose