Synthesis and combinational antibacterial study of 5''-modified neomycin.
A library of 5''-modified neomycin derivatives were synthesized for an antibacterial structure-activity optimization strategy. Two leads exhibited prominent activity against both methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE). Antibacterial activities were measured when combined with other clinically used antibiotics. Significant synergistic activities were observed, which may lead to the development of novel therapeutic practices in the battle against infectious bacteria.
Zhang
Jianjun
J
Department of Chemistry and Biochemistry, Utah State University, Logan, UT 84322-0300, USA.
Keller
Katherine
K
Takemoto
Jon Y
JY
Bensaci
Mekki
M
Litke
Anthony
A
Czyryca
Przemyslaw Greg
PG
Chang
Cheng-Wei Tom
CW
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D016983:Enterococcus / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D006801:Humans; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D009355:Neomycin / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D020713:Vancomycin Resistance
D000900:Anti-Bacterial Agents; D009355:Neomycin