Synthesis and biological evaluation of mercapto triazolo-benzothiadiazine linked aminobenzothiazoles as potential anticancer agents.
The synthesis of a series of 10-substituted 5,5-dioxo-5,10-dihydro[1,2,4]triazolo[4,3-b][1,2,4]benzothiadiazine coupled with sulfanylacetamido benzothiazole pharmacophores (5a-g) is described. All the synthesized compounds have been evaluated for their anticancer activity. Most of the compounds showed significant growth inhibitory activity against selected human tumor cell lines. Interestinlgy, one of the synthesized compounds 5d, exhibited GI(50) values of 1.4 and 2.1 microM against RPMI-8226 (leukemia) and HOP-62 (lungs) cell lines, respectively.
Kamal
Ahmed
A
Khan
Mohammed Naseer A
MN
Srikanth
Yellamelli V V
YV
Rajesh
Shetti V C R N C
SV
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001581:Benzothiadiazines / Q000737:chemistry*; D052160:Benzothiazoles / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D013438:Sulfhydryl Compounds / Q000737:chemistry*; D013450:Sulfones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D000970:Antineoplastic Agents; D001581:Benzothiadiazines; D052160:Benzothiazoles; C544208:N1-(6-methoxy-1,3-benzothiazol-2-yl)-2-((5,5-dioxo-10-phenyl-5,10-dihydro-5gamma6-benzo(e)(1,2,4)triazolo(4,3-b)(1,2,4)thiadiazin-3-yl)sulfanyl)acetamide; D013438:Sulfhydryl Compounds; D013450:Sulfones; C523775:aminobenzothiazole compound