title: Bayesian analysis for nonlinear regression model under skewed errors, with application in growth curves.
abstract: We have considered a Bayesian approach for the nonlinear regression model by replacing the normal distribution on the error term by some skewed distributions, which account for both skewness and heavy tails or skewness alone. The type of data considered in this paper concerns repeated measurements taken in time on a set of individuals. Such multiple observations on the same individual generally produce serially correlated outcomes. Thus, additionally, our model does allow for a correlation between observations made from the same individual. We have illustrated the procedure using a data set to study the growth curves of a clinic measurement of a group of pregnant women from an obstetrics clinic in Santiago, Chile. Parameter estimation and prediction were carried out using appropriate posterior simulation schemes based in Markov Chain Monte Carlo methods. Besides the deviance information criterion (DIC) and the conditional predictive ordinate (CPO), we suggest the use of proper scoring rules based on the posterior predictive distribution for comparing models. For our data set, all these criteria chose the skew-t model as the best model for the errors. These DIC and CPO criteria are also validated, for the model proposed here, through a simulation study. As a conclusion of this study, the DIC criterion is not trustful for this kind of complex model.
authors.affiliation: Departamento de Salud Pública, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile. rolando@med.puc.cl
authors.forename: Rolando
authors.initials: R
authors.lastname: De la Cruz
authors.forename: Márcia D
authors.initials: MD
authors.lastname: Branco
mesh_terms: D001499:Bayes Theorem; D002677:Chile / Q000453:epidemiology; D006063:Chorionic Gonadotropin / Q000097:blood*; D003198:Computer Simulation; D003627:Data Interpretation, Statistical; D005260:Female; D006801:Humans; D008954:Models, Biological; D015233:Models, Statistical; D017711:Nonlinear Dynamics; D011158:Population Growth; D011247:Pregnancy / Q000097:blood* / Q000706:statistics & numerical data; D011256:Pregnancy Outcome; D012044:Regression Analysis
chemical_list: D006063:Chorionic Gonadotropin