Highly sensitive and selective gold(I) recognition by a metalloregulator in Ralstonia metallidurans.
A MerR family metalloregulatory protein CupR selectively responds to gold stress in Ralstonia metallidurans. A distorted trigonal geometry appears to be used by CupR to achieve the highly sensitive (K(d) approximately 10(-35) M) and selective recognition of gold(I).
Jian
Xing
X
Department of Chemistry, 929 East 57th Street, The University of Chicago, Chicago, Illinois 60637, USA.
Wasinger
Erik C
EC
Lockard
Jenny V
JV
Chen
Lin X
LX
He
Chuan
C
D001426:Bacterial Proteins / Q000378:metabolism*; D006046:Gold / Q000493:pharmacokinetics*; D011485:Protein Binding; D043367:Ralstonia / Q000378:metabolism*
D001426:Bacterial Proteins; D006046:Gold