A short, economical synthesis of 2-methoxyestradiol, an anticancer agent in clinical trials.
2-Methoxyestradiol, a natural metabolite of estradiol and potential therapeutic agent for many types of cancers, has been synthesized successfully in three steps, starting from estradiol and cumyl methyl peroxide.
Hou
Yuqing
Y
Meyers Institute for Interdisciplinary Research in Organic and Medicinal Chemistry, and Department of Chemistry and Biochemistry, MC 4409, Southern Illinois University, Carbondale, Illinois 62901, USA. houyq@siu.edu
Meyers
Cal Y
CY
Akomeah
Mercy
M
D000077584:2-Methoxyestradiol; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry; D002986:Clinical Trials as Topic; D004958:Estradiol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D007202:Indicators and Reagents / Q000737:chemistry
D000970:Antineoplastic Agents; D007202:Indicators and Reagents; D004958:Estradiol; D000077584:2-Methoxyestradiol