title: Effects of platelet-rich plasma on intestinal wound healing in pigs.
abstract: Anastomotic dehiscence and leakage remain a major problem in gastrointestinal surgery. Recently, attention has been focused on cellular acceleration of the wound healing process using platelet-rich plasma (PRP) and this study reports the effects of PRP on intestinal wound healing in pigs. Autologous PRP was obtained from 35 pigs that were then subjected to two intestinal anastomosis procedures. Activated PRP was applied at one of the anastomosis sites, while the other site served as control. After 24, 48, 72 and 96 h and then at 7 days, histology was performed and wound breaking strength was measured at 72 h and 7 days. PRP application appeared to increase granulation tissue and fibrosis, but did not influence anastomotic breaking strength.
authors.affiliation: Departament de Medicina i Cirurgia Animals, Facultat de Veterinària, Universitat Autònoma de Barcelona, Bellaterra, Cerdanyola del Vallès, Barcelona, Spain. laura.fresno@uab.cat
authors.forename: Laura
authors.initials: L
authors.lastname: Fresno
authors.forename: Dolors
authors.initials: D
authors.lastname: Fondevila
authors.forename: Otilia
authors.initials: O
authors.lastname: Bambo
authors.forename: Asiul
authors.initials: A
authors.lastname: Chacaltana
authors.forename: Félix
authors.initials: F
authors.lastname: García
authors.forename: Anna
authors.initials: A
authors.lastname: Andaluz
mesh_terms: D000714:Anastomosis, Surgical; D000818:Animals; D007422:Intestines / Q000473:pathology / Q000502:physiology* / Q000601:surgery; D053657:Platelet-Rich Plasma; D013529:Surgical Wound Dehiscence / Q000517:prevention & control / Q000662:veterinary; D013552:Swine; D014945:Wound Healing / Q000502:physiology*