title: Grape juice, berries, and walnuts affect brain aging and behavior.
abstract: Numerous studies have indicated that individuals consuming a diet containing high amounts of fruits and vegetables exhibit fewer age-related diseases such as Alzheimer's disease. Research from our laboratory has suggested that dietary supplementation with fruit or vegetable extracts high in antioxidants (e.g. blueberries, strawberries, walnuts, and Concord grape juice) can decrease the enhanced vulnerability to oxidative stress that occurs in aging and these reductions are expressed as improvements in behavior. Additional mechanisms involved in the beneficial effects of fruits and vegetables include enhancement of neuronal communication via increases in neuronal signaling and decreases in stress signals induced by oxidative/inflammatory stressors (e.g. nuclear factor kappaB). Moreover, collaborative findings indicate that blueberry or Concord grape juice supplementation in humans with mild cognitive impairment increased verbal memory performance, thus translating our animal findings to humans. Taken together, these results suggest that a greater intake of high-antioxidant foods such as berries, Concord grapes, and walnuts may increase "health span" and enhance cognitive and motor function in aging.
authors.affiliation: USDA-Agricultural Research Service, Jean Mayer Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA. jim.joseph@ars.usda.gov
authors.forename: James A
authors.initials: JA
authors.lastname: Joseph
authors.forename: Barbara
authors.initials: B
authors.lastname: Shukitt-Hale
authors.forename: Lauren M
authors.initials: LM
authors.lastname: Willis
mesh_terms: D000375:Aging / Q000187:drug effects*; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D001519:Behavior / Q000187:drug effects*; D029798:Blueberry Plants; D001921:Brain / Q000187:drug effects*; D003072:Cognition Disorders / Q000188:drug therapy; D004032:Diet; D019587:Dietary Supplements; D031985:Fragaria; D005638:Fruit; D006801:Humans; D031324:Juglans; D019684:Magnoliopsida; D008569:Memory Disorders / Q000188:drug therapy; D018384:Oxidative Stress / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D015398:Signal Transduction / Q000187:drug effects; D027843:Vitis
chemical_list: D000975:Antioxidants; D010936:Plant Extracts