The Y's that bind: negative regulators of Src family kinase activity in platelets.
Members of the Src family of protein tyrosine kinases play important roles in platelet adhesion, activation, and aggregation. The purpose of this review is to summarize current knowledge regarding how Src family kinase activity is regulated in general, to describe what is known about mechanisms underlying SFK activation in platelets, and to discuss platelet proteins that contribute to SFK inactivation, particularly those that use phosphotyrosine-containing sequences to recruit phosphatases and kinases to sites of SFK activity.
Newman
D K
DK
Blood Center of Wisconsin, Blood Research Institute, Milwaukee, WI 53226, USA. Debra.Newman@bcw.edu
D001792:Blood Platelets / Q000201:enzymology* / Q000378:metabolism; D006801:Humans; D019000:Phosphotyrosine / Q000378:metabolism; D019061:src-Family Kinases / Q000378:metabolism*
D019000:Phosphotyrosine; D019061:src-Family Kinases