[Biochemical markers of bone turnover. New aspect. Bone metabolic markers available in daily practice].
Changes of bone remodeling markers reflect bone growth and bone turnover. Information on bone metabolism can be attained by blood and urine laboratory tests. Recently developed bone specific markers are categorized by bone remodeling process, i.e. bone formation and resorption. The formation markers include bone-specific alkaline phosphatase (BAP), osteocalcin (OC), undercarboxylated osteocalcin (ucOC), procollagene type I C- and N-terminal peptides (P1CP and P1NP). Bone resorption markers include deoxypyridinoline, collagen I C- and N-terminal telopeptides (CTX and NTX) , and tartrate resistent acid phosphatase (TRACP) isoform 5b. These laboratory tests offer lots of advantages for the diagnosis of bone metabolic disorders and for the evaluation of clinical states of primary osteoporosis and other metabolic skeletal diseases.
Wada
Seiki
S
Department of Clinical Sciences, Faculty of Pharmaceutical Sciences, Josai International Universtiy.
Fukawa
Takeshi
T
Kamiya
Sadahiro
S
D000135:Acid Phosphatase; D000469:Alkaline Phosphatase; D000596:Amino Acids; D015415:Biomarkers; D001846:Bone Development / Q000502:physiology*; D001851:Bone Diseases, Metabolic / Q000175:diagnosis* / Q000503:physiopathology; D016723:Bone Remodeling / Q000502:physiology*; D001862:Bone Resorption / Q000175:diagnosis; D001842:Bone and Bones / Q000378:metabolism*; D024042:Collagen Type I; D006801:Humans; D007527:Isoenzymes; D015675:Osteocalcin; D010012:Osteogenesis / Q000502:physiology*; D010446:Peptide Fragments; D010455:Peptides; D011347:Procollagen; D000071681:Tartrate-Resistant Acid Phosphatase
D000596:Amino Acids; D015415:Biomarkers; D024042:Collagen Type I; D007527:Isoenzymes; D010446:Peptide Fragments; D010455:Peptides; D011347:Procollagen; C052929:collagen type I trimeric cross-linked peptide; C047202:procollagen Type I N-terminal peptide; C042813:procollagen type I carboxy terminal peptide; D015675:Osteocalcin; C036020:deoxypyridinoline; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; D000071681:Tartrate-Resistant Acid Phosphatase