Blood flow rate measurements with indicator techniques revisited.
In view of the emerging role, disturbances in regional blood flow rate seem to play in the pathogenesis of the metabolic syndrome; we review the concepts of the classical indicator dilution and washout techniques used for determinations of regional blood flow rate. Prerequisites, assumptions, necessary precautions for the application of these experimental techniques are emphasized. Special attention has been carried out to elucidate the consequence of a choice of indicators having a large distribution volume in the tissues.
Sejrsen
Per
P
Department of Clinical Physiology and Nuclear Medicine, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.
Bülow
Jens
J
D000465:Algorithms; D001783:Blood Flow Velocity / Q000502:physiology*; D003198:Computer Simulation; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D006801:Humans; D007201:Indicator Dilution Techniques; D008955:Models, Cardiovascular; D012039:Regional Blood Flow / Q000502:physiology*; D012212:Rheology / Q000379:methods*