title: Sciatic nerve moneuropathy: an unusual late effect of radiotherapy.
abstract: In this study we report a progressive sciatic mononeuropathy occurring 13 years after radiotherapy (56-Gy prescribed dose) for a synovial sarcoma of the thigh. Conformal dosimetric reconstitution showed that irradiation was heterogeneous and that the sciatic nerve received 66 Gy over a 25-cm length. Magnetic resonance imaging (MRI) showed muscle fibrosis and increased sciatic nerve diameter. Our observation suggests that the risk of late mononeuropathy should be considered when large-volume and high-dose radiotherapy includes a nerve trunk.
authors.affiliation: Fédération des Maladies du Système Nerveux, Groupe Hospitalier Pitié-Salpêtrière, APHP, 47-83, Boulevard de l'Hôpital, 75651 Paris, France. pierre-francois.pradat@psl.aphp.fr
authors.forename: Pierre-François
authors.initials: PF
authors.lastname: Pradat
authors.forename: Pierre
authors.initials: P
authors.lastname: Bouche
authors.forename: Sylvie
authors.initials: S
authors.lastname: Delanian
mesh_terms: D000328:Adult; D006801:Humans; D008297:Male; D020422:Mononeuropathies / Q000175:diagnosis* / Q000209:etiology; D011832:Radiation Injuries / Q000175:diagnosis* / Q000209:etiology; D011879:Radiotherapy Dosage; D012584:Sciatic Nerve / Q000473:pathology* / Q000528:radiation effects*