Evaluation of certain constituents of antioxidant defense in youth treated in the past for steroid-sensitive idiopathic nephrotic syndrome.
Disorders of lipid metabolism and antioxidant defense capacity reported during idiopathic nephrotic syndrome (INS) exacerbations are known. The aim of this study was to evaluate constituents of antioxidant defense [total antioxidant potential: ferric-reducing antioxidant power (FRAP), paraoxonase-1 (PON-1), tocopherols, ascorbic acid] in patients formerly treated for INS. The studied group consisted of 30 patients (20 males and 10 females) treated 4-15 years ago for INS. The control group consisted of 30 healthy teenagers. There were no statistically significant differences in PON-1 activity (156.4 +/- 97.1 vs 137.7 +/- 80.2 U/l), alpha-tocopherol levels (23.9 +/- 7.3 vs 22.4 +/- 3.2 micromol/l) and sum of beta- and gamma-tocopherols (2.1 +/- 1.0 vs 2.3 +/- 0.6 micromol/l), and in FRAP (484.9 +/- 87.2 vs 452.8 +/- 76.9 micromol/l) between groups. In the study group, a significantly lower concentration of ascorbic acid (53.0 +/- 20.8 vs 69.4 +/- 16 micromol/l; p < 0.002), decreased values of alpha-tocopherol/cholesterol (4.9 +/- 0.7 vs 5.5 +/- 1.2; p = 0.03), and total tocopherol/cholesterol (5.3 +/- 0.8 vs 6.1 +/- 1.4; p = 0.016) ratios were observed. A positive correlation between tocopherol/total cholesterol (TCh) (r = 0.41; p < 0.05) and alpha-tocopherol/TCh (r = 0.50; p < 0.001) ratios and INS relapse frequency was reported. The relationship between the study parameters and group of variables (relapse frequency, duration of the last remission, age, gender) was tested using the multiple linear regression analysis. The results of this study suggest that the nonenzymatic antioxidant defense in young persons formerly treated for INS is weaker than in their healthy counterparts.
Kniazewska
Maria Hanna
MH
Department of Pediatrics in Bytom, Medical University of Silesia, Katowice, Poland. makn1@wp.pl
Obuchowicz
Anna Karolina
AK
Wielkoszyński
Tomasz
T
Zmudzińska-Kitczak
Joanna
J
Urban
Katarzyna
K
Hyla-Klekot
Lidia
L
D000293:Adolescent; D000886:Anthropometry; D000975:Antioxidants / Q000378:metabolism*; D043303:Aryldialkylphosphatase / Q000097:blood / Q000378:metabolism; D001205:Ascorbic Acid / Q000097:blood / Q000378:metabolism; D016022:Case-Control Studies; D002699:Chlorambucil / Q000627:therapeutic use; D002784:Cholesterol / Q000097:blood; D003520:Cyclophosphamide / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D005260:Female; D005290:Ferric Compounds / Q000378:metabolism; D005919:Glomerular Filtration Rate; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007407:Interviews as Topic; D007677:Kidney Function Tests; D008297:Male; D009404:Nephrotic Syndrome / Q000188:drug therapy* / Q000517:prevention & control*; D010808:Physical Examination; D011239:Prednisolone / Q000627:therapeutic use; D012008:Recurrence; D012074:Remission Induction; D012737:Sex Factors; D024505:Tocopherols / Q000097:blood / Q000378:metabolism
D000975:Antioxidants; D005290:Ferric Compounds; D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D002699:Chlorambucil; D003520:Cyclophosphamide; D002784:Cholesterol; D011239:Prednisolone; D043303:Aryldialkylphosphatase; D001205:Ascorbic Acid; D024505:Tocopherols