Role of SoxB1 transcription factors in development.
SoxB1 factors, which include Sox1, 2, and 3, share more than 90% amino acid identity in their DNA binding HMG box and participate in diverse developmental events. They are known to exert cell-type-specific functions in concert with other transcription factors on Sox factor-dependent regulatory enhancers. Due to the high degree of sequence similarity both within and outside the HMG box, SoxB1 members show almost identical biological activities. As a result, they exhibit strong functional redundancy in regions where SoxB1 members are coexpressed, such as neural stem/progenitor cells in the developing central nervous system.
Miyagi
Satoru
S
Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan.
Kato
Hidemasa
H
Okuda
Akihiko
A
D000818:Animals; D047108:Embryonic Development / Q000235:genetics; D053595:Embryonic Stem Cells / Q000378:metabolism; D005128:Eye Diseases / Q000235:genetics; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D007908:Lens, Crystalline / Q000166:cytology / Q000254:growth & development / Q000378:metabolism; D051379:Mice; D008957:Models, Genetic; D055748:SOXB1 Transcription Factors / Q000378:metabolism / Q000502:physiology*
D055748:SOXB1 Transcription Factors