title: Plasmon-induced photothermal cell-killing effect of gold colloidal nanoparticles on epithelial carcinoma cells.
abstract: Gold colloidal nanoparticles were prepared by the liquid laser ablation of a gold metal plate in water and also by the citrate reduction of HAuCl(4).4H2O. The gold colloidal nanoparticles with the plasmonic band strongly absorb light, which is converted to the photothermal energy. This photothermal energy gives a cytotoxic effect on epithelial carcinoma cells. Interestingly, we found that the size and shape of the nanoparticles are changed by light during the photothermal process in vitro. The cervical carcinoma cell line (HeLa cell) was incubated with the colloidal gold nanoparticles and then exposed to continuous visible light at 400-600 nm with UV- and heat-cutoff filters. The distinct cell-killing effect was observed by this procedure. In the absence of the gold colloidal nanoparticles, only a small amount of cells were photothermally destroyed.
authors.affiliation: Department of Chemistry and Bioscience, Faculty of Science, Kagoshima University, 1-21-35 Korimoto, Kagoshima, 890-0065, Japan.
authors.forename: Md
authors.initials: M
authors.lastname: Abdulla-Al-Mamun
authors.forename: Yoshihumi
authors.initials: Y
authors.lastname: Kusumoto
authors.forename: Aki
authors.initials: A
authors.lastname: Mihata
authors.forename: Md Shariful
authors.initials: MS
authors.lastname: Islam
authors.forename: Bashir
authors.initials: B
authors.lastname: Ahmmad
mesh_terms: D002277:Carcinoma / Q000532:radiotherapy*; D002470:Cell Survival / Q000528:radiation effects*; D005260:Female; D017979:Gold Colloid / Q000737:chemistry / Q000627:therapeutic use*; D006367:HeLa Cells; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry / Q000627:therapeutic use*; D010316:Particle Size; D010777:Photochemistry; D020349:Surface Plasmon Resonance; D002583:Uterine Cervical Neoplasms / Q000532:radiotherapy*
chemical_list: D017979:Gold Colloid