Human papillomavirus 16 and 18 L1 serology in Korean women with high-grade cervical intraepithelial neoplasia and cervical cancer.
We aimed to determine the prevalence of HPV-16/18 antibodies in Korean women with high-grade cervical intraepithelial neoplasia (CIN) and cervical cancer. We conducted the hospital-based case-control study at the university hospital between 2003 and 2006. Cases were 130 high-grade CIN and 43 cervical cancer patients and the control group was 106 women showing normal cervical cytology. Enzyme-linked immunosorbent assays were performed for HPV-16/18 L1 virus-like particles (VLPs) as an antigen. Seropositivity for HPV-16 VLP and HPV-18 VLP was found in 67.4% and 30.2% of cancer patients and 59.2% and 20.0% of high-grade CIN patients, respectively. Seropositivity for HPV-16 with high-grade CIN (OR 6.91; 95% CI 3.74-12.76) and cervical cancer (OR 8.99; 95% CI 3.88-20.84) presented significant associations, as did seropositivity for HPV-18 (high-grade CIN: OR 3.64; 95% CI 1.67-7.95, cervical cancer: OR 6.82; 95% CI 2.52-18.45). Patients with both HPV-16 and 18 seropositivity were 9.38 times (95% CI 2.98-29.51) more likely to have high-grade CIN and 17.05 times (95% CI 4.55-63.87) more likely to have cancer. Both HPV 16 and 18 L1 VLP serology is the clear disease predictors of presence of high-grade CIN and cervical cancer.
Jeong
Nan-Hee
NH
Department of Obstetrics and Gynecology, College of Medicine, Kyung-Hee University, Seoul, 130-702, Korea.
Woo
Mi-Kyung
MK
Lee
Nak-Woo
NW
Hur
Sook-Jin
SJ
Choi
Kum-Sook
KS
Kim
Hong-Jin
HJ
D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000097:blood*; D044466:Asian People; D036022:Capsid Proteins / Q000276:immunology*; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D052162:Human papillomavirus 16 / Q000276:immunology*; D052161:Human papillomavirus 18 / Q000276:immunology*; D006801:Humans; D007723:Korea / Q000453:epidemiology; D008875:Middle Aged; D011379:Prognosis; D016036:Seroepidemiologic Studies; D013997:Time Factors; D002583:Uterine Cervical Neoplasms / Q000208:ethnology / Q000473:pathology / Q000821:virology*; D014771:Virion / Q000276:immunology; D002578:Uterine Cervical Dysplasia / Q000208:ethnology / Q000473:pathology / Q000821:virology*
D000914:Antibodies, Viral; D036022:Capsid Proteins; C480565:L1 protein, Human papillomavirus type 18