A multinational, randomized, placebo-controlled trial to assess the immunogenicity, safety, and tolerability of live attenuated influenza vaccine coadministered with oral poliovirus vaccine in healthy young children.
Live attenuated influenza vaccine (LAIV) provides a useful tool to rapidly immunize populations in the developing world to prevent influenza outbreaks. In this noninferiority trial conducted in Asia and South America, where oral poliovirus vaccine (OPV) is still used, 2503 children aged 6 to <36 months with three polio immunizations were randomized to receive LAIV+OPV, placebo+OPV, or LAIV only. Immune responses in children receiving concomitant LAIV+OPV were noninferior to those observed in recipients of either vaccine alone. Response rates for different poliovirus types were similar in recipients of LAIV+OPV and placebo+OPV. Response rates to all influenza strains were similar in LAIV+OPV and LAIV-only recipients. Concomitant OPV and LAIV were safely administered to young children.
Breiman
Robert F
RF
Programme on Infectious Diseases and Vaccine Sciences, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Brooks
W Abdullah
WA
Goswami
Doli
D
Lagos
Rosanna
R
Borja-Tabora
Charissa
C
Lanata
Claudio F
CF
Londoño
Jaime A Cèspedes
JA
Lum
Lucy Chai See
LC
Rappaport
Ruth
R
Razmpour
Ahmad
A
Walker
Robert E
RE
Gruber
William C
WC
Forrest
Bruce D
BD
D000914:Antibodies, Viral / Q000097:blood; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007115:Immunization Schedule; D007223:Infant; D007252:Influenza Vaccines / Q000008:administration & dosage* / Q000009:adverse effects / Q000276:immunology; D007251:Influenza, Human / Q000517:prevention & control*; D008297:Male; D011051:Poliomyelitis / Q000517:prevention & control*; D011055:Poliovirus Vaccine, Oral / Q000008:administration & dosage* / Q000009:adverse effects / Q000276:immunology; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology
D000914:Antibodies, Viral; D007252:Influenza Vaccines; D011055:Poliovirus Vaccine, Oral; D014613:Vaccines, Attenuated