Heparin resistance during cardiopulmonary bypass.
The hemostatic system is activated during cardiopulmonary bypass (CPB) procedures, and the use of heparin attenuates the coagulation. However, heparin resistance occurs in between 4 and 22% of patients undergoing cardiac surgery, and the preoperative use of heparin is usually responsible for this. Sometimes, critically ill patients are referred for intra-aortic balloon pump (IABP) insertion, and anticoagulation therapy with heparin is recommended to prevent thrombosis and embolization. The author experienced heparin resistance in patients who underwent percutaneous coronary intervention (PCI) and IABP insertion.
Jung
Hyun Ju
HJ
Department of Anesthesiology and Pain Medicine, The Catholic University of Korea, College of Medicine, Seoul, Korea.
Kim
Jong Bun
JB
Im
Kyong Shil
KS
Oh
Seung Hwa
SH
Lee
Jae Myeong
JM
D000368:Aged; D000925:Anticoagulants / Q000494:pharmacology*; D002315:Cardiopulmonary Bypass; D004351:Drug Resistance; D004361:Drug Tolerance; D005260:Female; D006493:Heparin / Q000494:pharmacology*; D006801:Humans
D000925:Anticoagulants; D006493:Heparin