title: Abnormal MRI in a patient with 'headache with neurological deficits and CSF lymphocytosis (HaNDL)'.
abstract: A 27-year-old woman was admitted to the Emergency Department with right upper-extremity numbness and mild weakness followed by a bifrontal throbbing headache for 30 min, which was similar to a headache lasting for 12 h that had occurred 3 days ago. Laboratory tests were unremarkable except for cerebrospinal fluid (CSF) lymphocytic pleocytosis. On the following day, a headache episode with left hemiparesis and hemihypoaesthesia, left hemifield visio-spatial inattention, anosagnosia and confusion recurred. The headache was diagnosed as headache and neurological deficits with cerebrospinal fluid lymphocytosis (HaNDL) syndrome according to the criteria of the second edition of the International Classification of Headache Disorders. Simultaneously performed magnetic resonance imaging (MRI) revealed swelling of the grey matter, CSF enhancement in the sulci of the right temporal and occipital regions and hypoperfusion of the same brain regions. During the following 10 days two more similar episodes recurred and during the ensuing 12 months the patient remained headache free. Neuroimaging findings of the HaNDL syndrome are always thought as virtually normal. MRI abnormalities in our patient have not been reported in HaNDL syndrome previously, although they have been reported in hemiplegic migraine patients before. The findings in our case suggest that hemiplegic migraine and HaNDL syndrome may share a common pathophysiological pathway resulting in similar imaging findings and neurological symptoms.
authors.affiliation: Department of Neurology, School of Medicine, Mersin University, Mersin, Turkey. yilmazarda@hotmail.com
authors.forename: A
authors.initials: A
authors.lastname: Yilmaz
authors.forename: H
authors.initials: H
authors.lastname: Kaleagasi
authors.forename: O
authors.initials: O
authors.lastname: Dogu
authors.forename: E
authors.initials: E
authors.lastname: Kara
authors.forename: A
authors.initials: A
authors.lastname: Ozge
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology*; D005260:Female; D006261:Headache / Q000134:cerebrospinal fluid* / Q000150:complications / Q000473:pathology*; D006801:Humans; D008218:Lymphocytosis / Q000134:cerebrospinal fluid*; D008279:Magnetic Resonance Imaging; D010291:Paresis / Q000209:etiology