The role of autoimmune regulator (Aire) in the development of the immune system.
AIRE is the gene responsible for a rather rare hereditary type of autoimmune disease. The mechanism underlying the autoimmune pathogenesis caused by AIRE deficiency is a focus of intense research because it could provide clues to the fundamental question of how the immune system discriminates between self and non-self within the thymic microenvironment.
Matsumoto
Mitsuru
M
Division of Molecular Immunology, Institute for Enzyme Research, University of Tokushima, 3-18-15 Kuramoto, Tokushima 770-8503, Japan. mitsuru@ier.tokushima-u.ac.jp
D015551:Autoimmunity; D006801:Humans; D007107:Immune System / Q000254:growth & development*; D007108:Immune Tolerance; D013950:Thymus Gland / Q000276:immunology; D014157:Transcription Factors / Q000502:physiology*; D000096927:AIRE Protein
D014157:Transcription Factors; D000096927:AIRE Protein