title: Multiple origins of foot-and-mouth disease virus serotype Asia 1 outbreaks, 2003-2007.
abstract: We investigated the molecular epidemiology of foot-and-mouth disease virus (FMDV) serotype Asia 1, which caused outbreaks of disease in Asia during 2003-2007. Since 2004, the region affected by outbreaks of this serotype has increased from disease-endemic countries in southern Asia (Afghanistan, India, Iran, Nepal, Pakistan) northward to encompass Kyrgyzstan, Tajikistan, Uzbekistan, several regions of the People's Republic of China, Mongolia, Eastern Russia, and North Korea. Phylogenetic analysis of complete virus capsid protein 1 (VP1) gene sequences demonstrated that the FMDV isolates responsible for these outbreaks belonged to 6 groups within the Asia 1 serotype. Some contemporary strains were genetically closely related to isolates collected historically from the region as far back as 25 years ago. Our analyses also indicated that some viruses have spread large distances between countries in Asia within a short time.
authors.affiliation: Institute for Animal Health, Pirbright, UK.
authors.forename: Jean Francois
authors.initials: JF
authors.lastname: Valarcher
authors.forename: Nick J
authors.initials: NJ
authors.lastname: Knowles
authors.forename: Valery
authors.initials: V
authors.lastname: Zakharov
authors.forename: Alexey
authors.initials: A
authors.lastname: Scherbakov
authors.forename: Zhidong
authors.initials: Z
authors.lastname: Zhang
authors.forename: You Jun
authors.initials: YJ
authors.lastname: Shang
authors.forename: Zai Xin
authors.initials: ZX
authors.lastname: Liu
authors.forename: Xiang Tao
authors.initials: XT
authors.lastname: Liu
authors.forename: Aniket
authors.initials: A
authors.lastname: Sanyal
authors.forename: Divakar
authors.initials: D
authors.lastname: Hemadri
authors.forename: Chakradhar
authors.initials: C
authors.lastname: Tosh
authors.forename: Thaha J
authors.initials: TJ
authors.lastname: Rasool
authors.forename: Bramhadev
authors.initials: B
authors.lastname: Pattnaik
authors.forename: Kate R
authors.initials: KR
authors.lastname: Schumann
authors.forename: Tammy R
authors.initials: TR
authors.lastname: Beckham
authors.forename: Wilai
authors.initials: W
authors.lastname: Linchongsubongkoch
authors.forename: Nigel P
authors.initials: NP
authors.lastname: Ferris
authors.forename: Peter L
authors.initials: PL
authors.lastname: Roeder
authors.forename: David J
authors.initials: DJ
authors.lastname: Paton
mesh_terms: D000346:Afghanistan / Q000453:epidemiology; D000818:Animals; D001208:Asia / Q000453:epidemiology; D002681:China / Q000453:epidemiology; D004279:DNA, Viral / Q000235:genetics; D004196:Disease Outbreaks; D005536:Foot-and-Mouth Disease / Q000453:epidemiology*; D029544:Foot-and-Mouth Disease Virus / Q000145:classification / Q000235:genetics*; D005843:Geography; D006801:Humans; D007194:India / Q000453:epidemiology; D009390:Nepal / Q000453:epidemiology; D010154:Pakistan / Q000453:epidemiology; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012703:Serotyping
chemical_list: D004279:DNA, Viral; D012367:RNA, Viral