Bone regeneration during distraction osteogenesis.
Bone has the capacity to regenerate in response to injury. During distraction osteogenesis, the renewal of bone is enhanced by gradual stretching of the soft connective tissues in the gap area between two separated bone segments. This procedure has received much clinical attention as a way to correct congenital growth retardation of bone tissue or to generate bone to fill skeletal defects. The process of bone regeneration involves a complex system of biological changes whereby mechanical stress is converted into a cascade of signals that activate cellular behavior resulting in (enhanced) formation of bone. Over the last decade, significant progress has been made in understanding the bone regeneration process during distraction osteogenesis. The mechanical and biological factors that are important for the success of the distraction treatment have been partially characterized and are discussed in this review.
Amir
Lisa R
LR
Department of Oral Cell Biology, Academic Centre for Dentistry Amsterdam, Research Institute MOVE, University of Amsterdam, and VU University Amsterdam, Van der Boechorststr 7, 1081 BT Amsterdam, The Netherlands.
Everts
Vincent
V
Bronckers
Antonius L J J
AL
D000222:Adaptation, Physiological; D001861:Bone Regeneration / Q000502:physiology*; D020219:Chondrogenesis / Q000502:physiology; D006801:Humans; D010012:Osteogenesis / Q000502:physiology*; D019857:Osteogenesis, Distraction / Q000379:methods*; D013314:Stress, Mechanical