title: Influence of 70 nm silica particles in mice with cisplatin or paraquat-induced toxicity.
abstract: In the pharmaceutical industry, nano-size materials are designed as drug carriers and diagnosis probes. Interactions between nano-size materials and chemicals need investigating. Here, we investigated whether nano-size materials affect chemical-induced toxicity using silica particles, which have been widely used in cosmetics and drug delivery and have diameters of 70 (SP70), 300 (SP300) and 1000 (SP1000) nm, a popular anti-tumor agent, cisplatin, and a widely used herbicide, paraquat. Mice were treated with either cisplatin (100 micromol/kg, intraperitoneally) or paraquat (50 mg/kg, intraperitoneally), with or without intravenous silica particle administration. All treatments were non-lethal and did not show severe toxicity, except for injection with both cisplatin and SP70, which were lethal. When mice received with paraquat and/or the silica particles, synergistic enhanced toxicity was observed in both paraquat- and SP70-treated mice. These synergic effects were not observed with either Si300 or 1000 treatment. Our findings suggest that further evaluation on the interaction between nano-size materials and chemicals is critical for the pharmaceutical application of nanotechnology.
authors.affiliation: Laboratory of Bio-Functional Molecular Chemistry, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565-0871, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Nishimori
authors.forename: M
authors.initials: M
authors.lastname: Kondoh
authors.forename: K
authors.initials: K
authors.lastname: Isoda
authors.forename: S
authors.initials: S
authors.lastname: Tsunoda
authors.forename: Y
authors.initials: Y
authors.lastname: Tsutsumi
authors.forename: K
authors.initials: K
authors.lastname: Yagi
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D001219:Aspartate Aminotransferases / Q000097:blood; D001806:Blood Urea Nitrogen; D002945:Cisplatin / Q000633:toxicity*; D004357:Drug Synergism; D006540:Herbicides / Q000633:toxicity*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D053758:Nanoparticles; D010269:Paraquat / Q000633:toxicity*; D010316:Particle Size; D012822:Silicon Dioxide / Q000494:pharmacology*; D013535:Suspensions
chemical_list: D000970:Antineoplastic Agents; D006540:Herbicides; D013535:Suspensions; D012822:Silicon Dioxide; D001219:Aspartate Aminotransferases; D010269:Paraquat; D002945:Cisplatin