title: In vitro 24-hour time-kill studies of vancomycin and linezolid in combination versus methicillin-resistant Staphylococcus aureus.
abstract: Many clinicians are trying unique strategies, including vancomycin and linezolid in combination, for treatment of patients who do not respond to conventional therapy against methicillin (meticillin)-resistant Staphylococcus aureus. In our study, which illustrated in vitro activity only, no synergistic activity was seen when the two agents were combined. Conversely, antagonistic activity occurred in three of five strains when linezolid was added to vancomycin. Our results indicate that vancomycin and linezolid in combination should be avoided.
authors.affiliation: Department of Medicine-Pediatrics, Christiana Care Health System, 4755 Ogletown-Stanton Road, Newark, Delaware 19718, USA. ssingh@christianacare.org
authors.forename: Shveta Rani
authors.initials: SR
authors.lastname: Singh
authors.forename: Alfred E
authors.initials: AE
authors.lastname: Bacon
authors.forename: David C
authors.initials: DC
authors.lastname: Young
authors.forename: Kimberly A
authors.initials: KA
authors.lastname: Couch
mesh_terms: D000081:Acetamides / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004336:Drug Antagonism; D004357:Drug Synergism; D000069349:Linezolid; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D023303:Oxazolidinones / Q000494:pharmacology*; D014640:Vancomycin / Q000494:pharmacology*
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D014640:Vancomycin; D000069349:Linezolid