title: Biomechanical findings in rats undergoing fascial reconstruction with graft materials suggested as an alternative to polypropylene.
abstract: OBJECTIVE
  Graft materials used for pelvic floor reinforcement should still be considered as investigational and, therefore, evaluated experimentally and within clinical trials. The present report describes our biomechanical findings in rats implanted with selected novel implant materials, which in recent years have been suggested as alternatives to plain polypropylene (PP) meshes.
  
  
  METHODS
  Full thickness abdominal wall defects were primarily repaired by the implant of interest. Experiments involved eight different implant materials: two partly degradable synthetic implants, that is, a hybrid of polyglactin 910 with PP (Vypro II) and collagen coated PP (Pelvitex); two non-cross linked (Surgisis, InteXēn LP) and two cross-linked materials (Pelvicol, Pelvisoft) and two porous modifications of InteXēn LP and Pelvicol implants. At different time points (7, 14, 30, and 90 days), the implants and surrounding host tissue (explant) were harvested and tensiometry was performed. Tensile strength and location of breakage were recorded.
  
  
  RESULTS
  In general resorbable non-cross linked collagen matrices and porous materials were weaker after 90 days; similar behavior was seen for implant materials alone and their construction with the surrounding native tissue. Both non-porous and porous modification of InteXēn LP appeared at 90 days as a very thin layer of collagen that was two-thirds, respectively one-third of the initial thickness.
  
  
  CONCLUSIONS
  In experimental conditions, sufficient strength was obtained only after 3 months, and PP containing constructs appeared as the strongest though reconstruction with Pelvicol showed comparable outcomes. Lower values for strength of non-cross linked and porous collagen materials are questioning their efficacy for pelvic floor reconstruction.
authors.affiliation: Centre for Surgical Technologies, Catholic University Leuven, University Hospitals Gasthuisberg, Leuven, Belgium.
authors.forename: M L
authors.initials: ML
authors.lastname: Konstantinovic
authors.forename: Y
authors.initials: Y
authors.lastname: Ozog
authors.forename: F
authors.initials: F
authors.lastname: Spelzini
authors.forename: C
authors.initials: C
authors.lastname: Pottier
authors.forename: D
authors.initials: D
authors.lastname: De Ridder
authors.forename: J
authors.initials: J
authors.lastname: Deprest
mesh_terms: D034861:Abdominal Wall / Q000601:surgery*; D000818:Animals; D001696:Biomechanical Phenomena; D000071938:Fasciotomy; D008297:Male; D008422:Materials Testing; D011126:Polypropylenes; D019736:Prostheses and Implants; D051381:Rats; D017208:Rats, Wistar
chemical_list: D011126:Polypropylenes