title: Time trends in the incidence of conjunctival melanoma in Sweden.
abstract: OBJECTIVE
  To study time trends in the incidence of conjunctival melanoma in Sweden.
  
  
  METHODS
  All patients with conjunctival melanoma from 1960 to 2005 in Sweden were identified through the Swedish Cancer Registry, cross-checked against hospital files, and validated by histopathological review (97.5%) or detailed hospital records (2.5%). The crude and age-standardised incidences were estimated separately for each sex and the annual change in incidence over time was estimated using a regression model with logarithmic incidence numbers. Time trends for the largest diameter, thickness and location of the tumour when diagnosed were analysed.
  
  
  RESULTS
  The age-standardised incidence of conjunctival melanoma increased significantly in men (n = 89) from 0.10 cases/million to 0.74 cases/million (p = 0.001) and in women (n = 81) from 0.06 cases/million to 0.45 cases/million (p = 0.007). The annual relative change in age-standardised incidence was 16.9% (95% confidence interval (CI) 12.2 to 21.6) in men and 19.5% (95% CI 9.3 to 29.7) in women. The age-specific incidence was higher in men and women > or = 65 years (1.48 and 1.39 cases/million, respectively) than in younger men and women (0.3 and 0.2 cases/million, respectively). During the period of study, tumours became smaller (p = 0.005) and thinner (p = 0.002) at the time of diagnosis and increasingly arose from parts of the conjunctiva exposed to ultraviolet radiation (p = 0.001).
  
  
  CONCLUSIONS
  The incidence of conjunctival melanoma increased in Sweden during the period 1960 to 2005.
authors.affiliation: St Eriks Eye Hospital, Karolinska Institutet, SE 112 82 Stockholm, Sweden. eugenio.triay@sankterik.se
authors.forename: E
authors.initials: E
authors.lastname: Triay
authors.forename: L
authors.initials: L
authors.lastname: Bergman
authors.forename: B
authors.initials: B
authors.lastname: Nilsson
authors.forename: C
authors.initials: C
authors.lastname: All-Ericsson
authors.forename: S
authors.initials: S
authors.lastname: Seregard
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D003230:Conjunctival Neoplasms / Q000453:epidemiology*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008545:Melanoma / Q000453:epidemiology*; D008875:Middle Aged; D012042:Registries; D017678:Sex Distribution; D013548:Sweden / Q000453:epidemiology; D013997:Time Factors; D055815:Young Adult