title: Brain factor-7 extracted from Bombyx mori enhances cognition and attention in normal children.
abstract: It has been reported that brain factor-7 (BF-7) extracted from Bombyx mori improves cognitive functions in normal juveniles and adults as well as cognitively impaired patients. Clinical studies with normal children evaluated the role of BF-7 on brain function in these patients. The objective of this study was to improve cognitive functions of normal schoolchildren with BF-7. Forty-six normal healthy children were divided into two treatment groups: BF-7 (9.9 +/- 1.18 years old; 9 boys, 14 girls) and placebo (9.8 +/- 1.03 years old; 10 boys, 13 girls). The Color Trails Making Test was used to measure the efficacy of BF-7 on cognition and attention. Results showed that BF-7 reduced the response time by an average of 23% for the Color Trails Making Test. Moreover, BF-7 improved the accuracy of the task around twofold. The results reveal that BF-7 improves brain function for attention and cognitive flexibility in children.
authors.affiliation: Department of Psychiatry, University of Ulsan, Asan Medical Center, Seoul, Republic of Korea.
authors.forename: Kunwoo
authors.initials: K
authors.lastname: Kim
authors.forename: Subin
authors.initials: S
authors.lastname: Park
authors.forename: Hanik K
authors.initials: HK
authors.lastname: Yoo
authors.forename: Jun-Young
authors.initials: JY
authors.lastname: Lee
authors.forename: Hee-Yeon
authors.initials: HY
authors.lastname: Jung
authors.forename: Do-Hee
authors.initials: DH
authors.lastname: Kim
authors.forename: Hyun-Jung
authors.initials: HJ
authors.lastname: Lee
authors.forename: Jin-Young
authors.initials: JY
authors.lastname: Kim
authors.forename: Young-Chul
authors.initials: YC
authors.lastname: Youn
authors.forename: Maurice R
authors.initials: MR
authors.lastname: Marshall
authors.forename: Sung-Su
authors.initials: SS
authors.lastname: Kim
authors.forename: Yoonhwa
authors.initials: Y
authors.lastname: Jeong
mesh_terms: D000818:Animals; D001288:Attention / Q000187:drug effects*; D012831:Bombyx / Q000737:chemistry; D002648:Child; D003071:Cognition / Q000187:drug effects*; D005260:Female; D006801:Humans; D019476:Insect Proteins / Q000302:isolation & purification / Q000494:pharmacology*; D008297:Male; D009419:Nerve Tissue Proteins / Q000302:isolation & purification / Q000494:pharmacology*; D018697:Nootropic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D011930:Reaction Time; D012016:Reference Values; D014145:Trail Making Test
chemical_list: D019476:Insect Proteins; D009419:Nerve Tissue Proteins; D018697:Nootropic Agents