Association of polycystic ovary syndrome with cardiovascular risk factors.
BACKGROUND
Polycystic ovary syndrome (PCOS), also clinically known as Stein-Leventhal syndrome, is an endocrine disorder that affects 5-10% of women.


OBJECTIVE
To evaluate the risk factors for developing early onset of cardiovascular disease (CVD) in young patients with PCOS from our local population.


METHODS
Case-control study.


METHODS
Fifty women with PCOS selected by history and transvaginal ultrasounds and 30 age-matched healthy women (controls). The case subjects and controls were further divided into two age categories comprising of equal number of subjects, of 20-29 and 30-39 years of age. The subjects underwent a detailed medical history, general physical examination, systolic (SBP) and diastolic blood pressures (DBP). Fasting blood samples were analyzed for glucose, insulin, triacylglycerides (TAG), total cholesterol, high density lipoprotein-C (HDL-C), low density lipoprotein-C (LDL-C), follicle-stimulating hormone (FSH), and luteinizing hormone (LH).


RESULTS
Women with the PCOS had significantly higher mean arterial pressure (MAP), serum TAG, LDL-C, insulin, and LH levels when compared with the age-matched control subjects. No significant differences were observed between serum cholesterol, glucose, and FSH levels between cases and controls. However, no marked differences were observed in biochemical parameters between the two age groups of PCOS patients.


CONCLUSIONS
Younger women with PCOS are equally at risk of developing CVD as older women.
Akram
Tanzeela
T
Department of Physiology and Cell Biology, University of Health Sciences (UHS), Khayaban-e-Jamia Punjab, Lahore, Pakistan. tanzeela_w@hotmail.com
Hasan
Shahid
S
Imran
Muhammad
M
Karim
Asima
A
Arslan
Muhammad
M
D000328:Adult; D001786:Blood Glucose / Q000032:analysis / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000097:blood / Q000209:etiology*; D016022:Case-Control Studies; D005215:Fasting / Q000097:blood / Q000378:metabolism; D005260:Female; D006062:Gonadotropins / Q000097:blood; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology; D008055:Lipids / Q000097:blood; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000150:complications*; D012307:Risk Factors; D055815:Young Adult
D001786:Blood Glucose; D006062:Gonadotropins; D007328:Insulin; D008055:Lipids