title: Effect of smoking on activity of N-acetyl-beta-hexosaminidase in serum and urine of renal cancer patients.
abstract: OBJECTIVE
  To compare N-acetyl-beta-hexosaminidase (HEX) activity in the serum and urine of smokers as well as non-smokers with renal cancer, and healthy people.
  
  
  METHODS
  To assess hexosaminidase activity the level of p-nitrophenol released from p-nitrophenol derivatives was measured.
  
  
  RESULTS
  The activity of enzyme was significantly higher in cancer group, with the highest activity in non-smokers.
  
  
  CONCLUSIONS
  Cigarette smoking can inhibit, by the influence on HEX activity, catabolism of oligosaccharide chains in cancer tissues.
authors.affiliation: Department of Pharmaceutical Biochemistry, Medical University, Bialystok, Poland. gocha@umwb.edu.pl
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Borzym-Kluczyk
authors.forename: Iwona
authors.initials: I
authors.lastname: Radziejewska
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Zaniewska
authors.forename: Anna
authors.initials: A
authors.lastname: Borzym-Lewszuk
authors.forename: Sławomir Dariusz
authors.initials: SD
authors.lastname: Szajda
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Knaś
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Zwierz
authors.forename: Barbara
authors.initials: B
authors.lastname: Darewicz
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood / Q000652:urine; D006801:Humans; D007680:Kidney Neoplasms / Q000097:blood / Q000201:enzymology / Q000652:urine; D009596:Nitrophenols / Q000378:metabolism; D009844:Oligosaccharides / Q000378:metabolism; D012307:Risk Factors; D012907:Smoking / Q000097:blood / Q000652:urine; D001619:beta-N-Acetylhexosaminidases / Q000097:blood / Q000652:urine
chemical_list: D014408:Biomarkers, Tumor; D009596:Nitrophenols; D009844:Oligosaccharides; D001619:beta-N-Acetylhexosaminidases; C024836:4-nitrophenol