title: [Nutrition and bone health. Roles of vitamin C and vitamin B as regulators of bone mass and quality].
abstract: Vitamin C and a vitamin B are essential nutrients to maintain bone density and bone quality. Recent literature clearly shows that vitamin C and B affect bone quality determinant "collagen cross-link formation" . Mildly elevated plasma homocysteine levels induced by vitamin B insufficiency and methylenetetrahydrofolate reductase (MTHFR) deteriorate normal collagen cross-link formation (Saito M, Osteoporos Int 2009 May 30. [Epub ahead of print] , Shiraki M and Saito M, J Bone Miner Metab [6] 2008) . In this review, we describe the effects of vitamin C and vitamin B insufficiency and hyperhomocysteinemia on bone quality in terms of collagen cross-link formation in bone that have been reported in the literature.
authors.affiliation: Department of Orthopaedic Surgery, Jikei University School of Medicine.
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Saito
mesh_terms: D001205:Ascorbic Acid / Q000502:physiology*; D001206:Ascorbic Acid Deficiency / Q000503:physiopathology; D015519:Bone Density; D003094:Collagen / Q000378:metabolism; D006710:Homocysteine / Q000378:metabolism; D006801:Humans; D020138:Hyperhomocysteinemia / Q000503:physiopathology; D014803:Vitamin B Complex / Q000502:physiology*; D014804:Vitamin B Deficiency / Q000503:physiopathology
chemical_list: D006710:Homocysteine; D014803:Vitamin B Complex; D003094:Collagen; D001205:Ascorbic Acid