title: New quantitative method for bone tracer uptake of temporomandibular joint using Tc-99m MDP skull SPECT.
abstract: OBJECTIVE
  Quantitative bone SPECT studies have several advantages over qualitative studies for evaluating a temporomandibular joint (TMJ), yet in certain cases additional images are still needed. Accordingly, the current study developed a new easy SPECT quantification method for the bone tracer uptake in a TMJ and evaluated its usefulness and inter-observer variability in patients with TMJ pain.
  
  
  METHODS
  Sixty-six adult patients (11 males, 55 females) with a mean age of 31 years (range 22-79 years) suffering from TMJ pain were questioned regarding the history of their condition, and then subjected to an oromaxillofacial examination and bone SPECT. New quantitative data for TMJs (TMJ index) were calculated from a formula using TMJ and skull counts.
  
  
  RESULTS
  TMJs with spontaneous pain had higher TMJ indices than those without spontaneous pain (8.87 vs. 6.87, P = 0.032). TMJs with mouth-opening pain or palpatory pain also exhibited higher TMJ indices than those without such pains, although the differences were not statistically significant. Positive TMJs, according to a visual SPECT interpretation, had much higher TMJ indices than the negative ones (8.99 vs. 5.37, P < 0.001). The reference skull count, mean TMJ count and TMJ index obtained using the proposed TMJ quantification method demonstrated an excellent correlation based on two independent observers (r = 0.996, r = 0.993 and r = 0.989, respectively; P < 0.001).
  
  
  CONCLUSIONS
  The current results indicate that the proposed quantitative TMJ bone SPECT is easy to perform, plus the resulting TMJ index has a lower inter-observer variability, making it an effective TMJ evaluation method for patients with painful TMJs, and especially useful for serial studies.
authors.affiliation: Department of Nuclear Medicine, School of Medicine, Kyungpook National University, Daegu 700-721, South Korea. abc2000@knu.ac.kr
authors.forename: Byeong-Cheol
authors.initials: BC
authors.lastname: Ahn
authors.forename: Hae-Joo
authors.initials: HJ
authors.lastname: Kim
authors.forename: Sang-Woo
authors.initials: SW
authors.lastname: Lee
authors.forename: Jeongsoo
authors.initials: J
authors.lastname: Yoo
authors.forename: Jae-Kap
authors.initials: JK
authors.lastname: Choi
authors.forename: Jaetae
authors.initials: J
authors.lastname: Lee
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D010146:Pain / Q000000981:diagnostic imaging / Q000378:metabolism; D011849:Radioactive Tracers; D015203:Reproducibility of Results; D012886:Skull / Q000000981:diagnostic imaging*; D013669:Technetium Tc 99m Medronate / Q000378:metabolism*; D013704:Temporomandibular Joint / Q000378:metabolism* / Q000473:pathology; D013705:Temporomandibular Joint Disorders / Q000000981:diagnostic imaging / Q000378:metabolism; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods* / Q000706:statistics & numerical data; D055815:Young Adult
chemical_list: D011849:Radioactive Tracers; D013669:Technetium Tc 99m Medronate