[Pathogenesis of post-transplantation diabetes mellitus in 40 renal transplantation recipients].
OBJECTIVE
To explore pathogenesis of post-transplantation diabetes mellitus (PTDM) in renal transplantation recipients.


METHODS
A total of 40 renal transplantation recipients were divided into three groups based on oral glucose tolerance test results: normal glucose tolerance (NGT) group (n = 10), impaired fasting glycaemia + impaired glucose tolerance (IFG + IGT) group (n = 16), and PTDM group (n = 14). Insulin resistance (IR) and beta cell function were assessed by homeostasis model.


RESULTS
The differences of the immunosuppressive agents used in these groups were not statistically significant (P > 0.05). Compared with NGT group, insulin area under curve and homeostasis model assessment-insulin resistance index were significantly higher in IGT + IFG group and PTDM group (P < 0.05). Compared with NGT group and IGT + IPG group, insulin secretion index at 30 min and homeostasis model assessment-insulin secretion index were significantly lower in PTDM group (P < 0.05).


CONCLUSIONS
Insulin resistance and beta-cell dysfunction may play a key role in the pathogenesis of PTDM.
Wang
Zhen
Z
Organ Transplantation Center, the Second Affiliated Hospital of PLA General Hospital, Beijing 100091, China.
Shi
Bing-yi
BY
Zheng
Hui-li
HL
Qian
Ye-yong
YY
Han
Meng-xia
MX
D000328:Adult; D003920:Diabetes Mellitus / Q000209:etiology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D050417:Insulin-Secreting Cells / Q000502:physiology; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000209:etiology / Q000503:physiopathology; D012189:Retrospective Studies; D055815:Young Adult