Role of transporter proteins in bile tolerance of Lactobacillus acidophilus.
Lactobacillus acidophilus NCFM derivatives containing deletion mutations in the transporter genes LBA0552, LBA1429, LBA1446, and LBA1679 exhibited increased sensitivity to bile. These strains showed unique patterns of sensitivity to a variety of inhibitory compounds, as well as differential accumulations of ciprofloxacin and taurocholate.
Pfeiler
Erika A
EA
Genomic Sciences Graduate Program, Department of Food, Bioprocessing, & Nutrition Sciences, North Carolina State University, Raleigh, NC 27695, USA.
Klaenhammer
Todd R
TR
D000900:Anti-Bacterial Agents / Q000378:metabolism / Q000494:pharmacology*; D001646:Bile / Q000737:chemistry* / Q000378:metabolism; D002939:Ciprofloxacin / Q000378:metabolism / Q000494:pharmacology; D003902:Detergents / Q000378:metabolism / Q000494:pharmacology*; D017353:Gene Deletion; D005798:Genes, Bacterial; D007779:Lactobacillus acidophilus / Q000187:drug effects* / Q000502:physiology*; D026901:Membrane Transport Proteins / Q000235:genetics / Q000378:metabolism*; D050296:Microbial Viability; D013656:Taurocholic Acid / Q000378:metabolism / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D003902:Detergents; D026901:Membrane Transport Proteins; D013656:Taurocholic Acid; D002939:Ciprofloxacin