title: The novel histone deacetylase inhibitors metacept-1 and metacept-3 potently increase HIV-1 transcription in latently infected cells.
abstract: We investigated the ability of several novel class I histone deacetylase inhibitors to activate HIV-1 transcription in latently infected cell lines. Oxamflatin, metacept-1 and metacept-3 induced high levels of HIV-1 transcription in latently infected T cell and monocytic cells lines, were potent inhibitors of histone deacetylase activity and caused preferential cell death in transcriptionally active cells. Although these compounds had potent in-vitro activity, their cytotoxicity may limit their use in patients.
authors.affiliation: Infectious Diseases Unit, Alfred Hospital, Melbourne, Victoria, Australia.
authors.forename: Miranda
authors.initials: M
authors.lastname: Shehu-Xhilaga
authors.forename: David
authors.initials: D
authors.lastname: Rhodes
authors.forename: Fiona
authors.initials: F
authors.lastname: Wightman
authors.forename: Hong B
authors.initials: HB
authors.lastname: Liu
authors.forename: Ajantha
authors.initials: A
authors.lastname: Solomon
authors.forename: Suha
authors.initials: S
authors.lastname: Saleh
authors.forename: Anthony E
authors.initials: AE
authors.lastname: Dear
authors.forename: Paul U
authors.initials: PU
authors.lastname: Cameron
authors.forename: Sharon R
authors.initials: SR
authors.lastname: Lewin
mesh_terms: D016923:Cell Death / Q000187:drug effects; D002460:Cell Line; D004353:Drug Evaluation, Preclinical / Q000379:methods; D015497:HIV-1 / Q000187:drug effects* / Q000235:genetics / Q000502:physiology; D056572:Histone Deacetylase Inhibitors; D006655:Histone Deacetylases / Q000378:metabolism; D006801:Humans; D006877:Hydroxamic Acids / Q000494:pharmacology*; D013449:Sulfonamides / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000821:virology*; D015533:Transcriptional Activation / Q000187:drug effects*; D017735:Virus Latency / Q000187:drug effects
chemical_list: D056572:Histone Deacetylase Inhibitors; D006877:Hydroxamic Acids; D013449:Sulfonamides; C527236:metacept-1; C100692:oxamflatin; D006655:Histone Deacetylases