title: Dopaminergic modulation of olfactory bulb processing affects odor discrimination learning in rats.
abstract: Olfactory behavioral studies have shown that, when modulated through systemic injections, D1 and D2 receptors have opposing effects on odor discrimination learning. In the present study, cannulated male Sprague-Dawley rats were used to investigate how the modulation of these 2 types of dopaminergic receptors through direct infusion of D1/D2 agonists and antagonists into the olfactory bulb affect olfactory perception. Dopaminergic modulation was locally altered by manipulations of D1 (agonist SKF 82958: 14.6, 43.8, & 143.6 mM; antagonist SCH-23390: 13.4, 40.1, & 60.1 mM) and D2 (agonists quinpirole: 78.2, 117.3, & 156.4 mM; antagonist sulpiride: 0.3, 0.9, & 2.9 mM) receptors during a simultaneous odor discrimination task. The authors found that modulation of D2, but not D1, receptors significantly affected rats' odor discrimination performance. A significant positive correlation between blockade of D2 receptors and discrimination performance, as well as a significant negative correlation between D2 receptor activation and discrimination performance, was observed.
authors.affiliation: Computational Physiology Lab, Neurobiology and Behavior, Cornell University, Ithaca, NY 14853, USA.
authors.forename: Olga
authors.initials: O
authors.lastname: Escanilla
authors.forename: Courtney
authors.initials: C
authors.lastname: Yuhas
authors.forename: David
authors.initials: D
authors.lastname: Marzan
authors.forename: Christiane
authors.initials: C
authors.lastname: Linster
mesh_terms: D000818:Animals; D001552:Benzazepines / Q000494:pharmacology; D004193:Discrimination Learning / Q000187:drug effects / Q000502:physiology*; D004298:Dopamine / Q000502:physiology*; D018491:Dopamine Agonists / Q000494:pharmacology; D018492:Dopamine Antagonists / Q000494:pharmacology; D065127:Dopamine D2 Receptor Antagonists; D004305:Dose-Response Relationship, Drug; D008297:Male; D009483:Neuropsychological Tests; D009812:Odorants; D009830:Olfactory Bulb / Q000187:drug effects / Q000502:physiology*; D055696:Olfactory Perception / Q000187:drug effects / Q000502:physiology*; D010812:Physical Stimulation; D019257:Quinpirole / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D017447:Receptors, Dopamine D1 / Q000819:agonists / Q000037:antagonists & inhibitors / Q000378:metabolism*; D017448:Receptors, Dopamine D2 / Q000819:agonists / Q000378:metabolism*; D013469:Sulpiride / Q000494:pharmacology
chemical_list: D001552:Benzazepines; D018491:Dopamine Agonists; D018492:Dopamine Antagonists; D065127:Dopamine D2 Receptor Antagonists; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; C534628:SCH 23390; D019257:Quinpirole; D013469:Sulpiride; C071262:SK&F 82958; D004298:Dopamine