Direct synthesis of highly substituted thiophenes through copper(i)-catalyzed tandem reactions of alkylidenethiiranes with terminal alkynes.
A novel copper(i)-catalyzed tandem addition/cycloisomerization reaction of 1-phenylsulfonylalkylidenethiiranes with terminal alkynes for the convergent assembly of 2-(alpha-phenylsulfonylalkyl)-thiophenes is reported, which could directly assemble various functional groups incorporated into the thiophene ring.
Zhang
Yiping
Y
Department of Chemistry, Zhejiang University, Hangzhou, China.
Bian
Ming
M
Yao
Weijun
W
Gu
Jianming
J
Ma
Cheng
C
D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D007536:Isomerism; D015394:Molecular Structure; D013876:Thiophenes / Q000737:chemistry*
D000480:Alkynes; D013876:Thiophenes; D003300:Copper