Nanodiamonds as vehicles for systemic and localized drug delivery.
Owing to their exceptional biocompatibility and unique surface properties, nanodiamonds (NDs) are shown to be a progressively promising nanomaterial for drug delivery. In this article, NDs as a platform for a host of biomedical applications are described, with an emphasis on cancer therapy, ranging from systemic modalities to primary constituents within polymer hybrid microfilms. Experimental results and theoretical explanations of ND-drug dynamics are compared. Water-dispersion of previously insoluble therapeutics when complexed with NDs demonstrates great promise in expanding current drug delivery options. Various forms of incorporating NDs within microfilms as a localized drug release coating and implant are also discussed.
Lam
Robert
R
Northwestern University, Robert R McCormick School of Engineering and Applied Science, Department of Mechanical Engineering, Evanston, IL 60208, USA.
Ho
Dean
D
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage; D001672:Biocompatible Materials / Q000737:chemistry; D018130:Diamond / Q000737:chemistry*; D016503:Drug Delivery Systems; D006801:Humans; D049329:Nanostructures / Q000737:chemistry*; D009369:Neoplasms / Q000188:drug therapy; D013499:Surface Properties
D000970:Antineoplastic Agents; D001672:Biocompatible Materials; D018130:Diamond