title: First case of granulomatous amebic encephalitis caused by Acanthamoeba castellanii in Taiwan.
abstract: We report the first case of granulomatous amebic encephalitis caused by Acanthamoeba in a previously healthy farmer in Taiwan who fell into a ditch. The DNA amplicons of amebas identified by polymerase chain reaction in the cerebrospinal fluid specimen and the ditch water specimens were identical and shared strong homology with A. castellanii . He survived after treatment with amphotericin B, rifampin, and corticosteroids.
authors.affiliation: Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan. whsheng@ntu.edu.tw
authors.forename: Wang-Huei
authors.initials: WH
authors.lastname: Sheng
authors.forename: Chien-Ching
authors.initials: CC
authors.lastname: Hung
authors.forename: Huai-Hsuan
authors.initials: HH
authors.lastname: Huang
authors.forename: Shih-Yu
authors.initials: SY
authors.lastname: Liang
authors.forename: Yu-Jen
authors.initials: YJ
authors.lastname: Cheng
authors.forename: Dar-Der
authors.initials: DD
authors.lastname: Ji
authors.forename: Shan-Chwen
authors.initials: SC
authors.lastname: Chang
mesh_terms: D048248:Acanthamoeba castellanii / Q000235:genetics / Q000302:isolation & purification*; D000562:Amebiasis / Q000134:cerebrospinal fluid / Q000453:epidemiology / Q000473:pathology*; D000818:Animals; D016054:DNA, Protozoan / Q000235:genetics; D004660:Encephalitis / Q000134:cerebrospinal fluid / Q000453:epidemiology / Q000469:parasitology*; D006099:Granuloma / Q000134:cerebrospinal fluid / Q000453:epidemiology / Q000469:parasitology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010802:Phylogeny; D013624:Taiwan / Q000453:epidemiology
chemical_list: D016054:DNA, Protozoan