Anticardiolipin antibodies in the sera of patients with diagnosed chronic fatigue syndrome.
Examination of anticardiolipin antibodies (ACAs) in the sera of patients clinically diagnosed with chronic fatigue syndrome (CFS) using an enzyme-linked immunoassay procedure demonstrated the presence of immunoglobulin M isotypes in 95% of CFS serum samples tested. The presence of immunoglobulin G and immunoglobulin A isotypes were also detected in a subset of the samples. Future studies will focus on elucidating whether alterations to mitochondrial inner membranes and/or metabolic functions play a possible role in the expression of ACAs.
Hokama
Yoshitsugi
Y
Department of Pathology, John A. Burns School of Medicine, University of Hawaii at Mânoa, Honolulu, Hawaii 96822, USA.
Campora
Cara Empey
CE
Hara
Cynthia
C
Kuribayashi
Tina
T
Le Huynh
Diana
D
Yabusaki
Kenichi
K
D000328:Adult; D000368:Aged; D017153:Antibodies, Anticardiolipin / Q000097:blood*; D002308:Cardiolipins / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D015673:Fatigue Syndrome, Chronic / Q000276:immunology* / Q000473:pathology; D005260:Female; D006801:Humans; D007132:Immunoglobulin Isotypes / Q000276:immunology*; D007075:Immunoglobulin M / Q000276:immunology; D008297:Male; D008875:Middle Aged; D008930:Mitochondria, Liver / Q000276:immunology
D017153:Antibodies, Anticardiolipin; D002308:Cardiolipins; D007132:Immunoglobulin Isotypes; D007075:Immunoglobulin M