title: Computed tomography-based tumor volume in non-Hodgkin lymphoma: clinical correlation and comparison with magnetic resonance imaging.
abstract: OBJECTIVE
  To evaluate the prognostic significance of tumor volume in computed tomographic (CT) images of non-Hodgkin lymphoma patients. To compare CT volumes with those measured by magnetic resonance imaging (MRI).
  
  
  METHODS
  Twenty-five patients with B cell-type non-Hodgkin lymphoma (16 men, 9 women, age range, 48-77 years) were imaged with CT at 5 time points. The volumes and volume reductions were associated with clinical characteristics and treatment outcome. The CT-derived tumor volumes were correlated with MRI volumes derived earlier for the same patients.
  
  
  RESULTS
  Good agreement was found between 1-dimensional (1D), 2D, and 3D analyses. The CT-derived median tumor volumes were 306 cm, 174 cm, 75 cm, 28 cm, and 15 cm at the 5 time points. These volumes were found to associate, for example, with mortality and tumor malignancy. The CT-based tumor volumes showed good correlation with MRI.
  
  
  CONCLUSIONS
  Tumor volume quantification is a powerful tool that associates with clinical characteristics and treatment outcome.
authors.affiliation: Regional Medical Imaging Centre, Department of Diagnostic Radiology, Tampere University Hospital, Tampere, Finland. maija.rossi@pshp.fi
authors.forename: Maija
authors.initials: M
authors.lastname: Rossi
authors.forename: Hannu
authors.initials: H
authors.lastname: Pertovaara
authors.forename: Prasun
authors.initials: P
authors.lastname: Dastidar
authors.forename: Ritva
authors.initials: R
authors.lastname: Järvenpää
authors.forename: Tiina
authors.initials: T
authors.lastname: Luukkaala
authors.forename: Sylvia
authors.initials: S
authors.lastname: Rautakunnas
authors.forename: Tomi
authors.initials: T
authors.lastname: Heinonen
authors.forename: Hannu
authors.initials: H
authors.lastname: Eskola
authors.forename: Seppo
authors.initials: S
authors.lastname: Soimakallio
authors.forename: Pirkko-Liisa
authors.initials: PL
authors.lastname: Kellokumpu-Lehtinen
mesh_terms: D000368:Aged; D003287:Contrast Media; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D021621:Imaging, Three-Dimensional / Q000379:methods; D007472:Iohexol; D016393:Lymphoma, B-Cell / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011856:Radiographic Image Enhancement / Q000379:methods; D015203:Reproducibility of Results; D016019:Survival Analysis; D014057:Tomography, X-Ray Computed / Q000379:methods*; D016896:Treatment Outcome; D047368:Tumor Burden
chemical_list: D003287:Contrast Media; D007472:Iohexol