title: Chain reactions: early-life stress alters the metabolic profile of plasma polyunsaturated fatty acids in adulthood.
abstract: The rat maternal separation paradigm can be used to examine the biological consequences of early-life stress. Immunomodulatory polyunsaturated fatty acids (PUFAs) have recently attracted attention in the study of stress-related disorders. We established the plasma PUFA profile of maternally separated rodents compared to controls. Our results identify a proinflammatory PUFA profile as a persistent consequence of early-life stress and suggest new avenues of investigation in stress-related disorders.
authors.affiliation: Department of Psychiatry, University College Cork, Cork, Ireland; Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland. g.clarke@ucc.ie
authors.forename: Gerard
authors.initials: G
authors.lastname: Clarke
authors.forename: Siobhain M
authors.initials: SM
authors.lastname: O'Mahony
authors.forename: Alan A
authors.initials: AA
authors.lastname: Hennessy
authors.forename: Paul
authors.initials: P
authors.lastname: Ross
authors.forename: Catherine
authors.initials: C
authors.lastname: Stanton
authors.forename: John F
authors.initials: JF
authors.lastname: Cryan
authors.forename: Timothy G
authors.initials: TG
authors.lastname: Dinan
mesh_terms: D000375:Aging; D000818:Animals; D016718:Arachidonic Acid / Q000097:blood; D004195:Disease Models, Animal; D015525:Fatty Acids, Omega-3 / Q000097:blood; D043371:Fatty Acids, Omega-6 / Q000097:blood; D005231:Fatty Acids, Unsaturated / Q000097:blood*; D008297:Male; D008426:Maternal Deprivation; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013315:Stress, Psychological / Q000097:blood*; D013997:Time Factors
chemical_list: D015525:Fatty Acids, Omega-3; D043371:Fatty Acids, Omega-6; D005231:Fatty Acids, Unsaturated; D016718:Arachidonic Acid