title: Neurophysiological and functional MRI evidence of reorganization of cortical motor areas in cerebral arteriovenous malformation.
abstract: Functional magnetic resonance imaging (fMRI) research has shown that brain arteriovenous malformations (AVMs) lead to reorganization of cortical motor areas. Since it is known that blood oxygenation level-dependent signal in fMRI may be influenced by the hemodynamic perturbation associated with the presence of the AVM, in the present study, a combined exploration with fMRI and transcranial magnetic stimulation was performed in a patient with a right rolandic AVM in order to explore the relationship between neuronal and hemodynamic activity. The combined protocol of investigation adopted in this study was able to provide significant information regarding neuronal activity of the different cortical areas that partake to post-lesional reorganization.
authors.affiliation: Department of Neurological Sciences, University of Rome La Sapienza, Rome, Italy. francesca.caramia@uniroma1.it
authors.forename: Francesca
authors.initials: F
authors.lastname: Caramia
authors.forename: Ada
authors.initials: A
authors.lastname: Francia
authors.forename: Caterina
authors.initials: C
authors.lastname: Mainero
authors.forename: Emanuele
authors.initials: E
authors.lastname: Tinelli
authors.forename: Maria Giuseppina
authors.initials: MG
authors.lastname: Palmieri
authors.forename: Claudio
authors.initials: C
authors.lastname: Colonnese
authors.forename: Luigi
authors.initials: L
authors.lastname: Bozzao
authors.forename: Maria Donatella
authors.initials: MD
authors.lastname: Caramia
mesh_terms: D000328:Adult; D001921:Brain / Q000502:physiology; D002533:Cerebral Angiography / Q000379:methods; D002540:Cerebral Cortex / Q000473:pathology / Q000503:physiopathology*; D005260:Female; D006439:Hemodynamics; D006801:Humans; D002538:Intracranial Arteriovenous Malformations / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008959:Models, Neurological; D009474:Neurons / Q000378:metabolism / Q000502:physiology; D009482:Neurophysiology; D010292:Paresthesia / Q000503:physiopathology; D050781:Transcranial Magnetic Stimulation