Efficient translational rehabilitation randomised controlled trial designs using disease progress modelling and trial simulation.
Given the challenges inherent in randomised trials of rehabilitation interventions, methods are required to increase trial efficiency and information yield. This paper discusses, in a non-technical manner, a class of statistical models that is particularly suited to the task of detecting potential treatment effects against a background of spontaneous change.
Forsyth
Rob
R
Institute of Neuroscience, Newcastle University, UK. r.j.forsyth@newcastle.ac.uk
D001930:Brain Injuries / Q000534:rehabilitation*; D003198:Computer Simulation; D018450:Disease Progression; D006801:Humans; D015233:Models, Statistical; D017711:Nonlinear Dynamics; D016032:Randomized Controlled Trials as Topic / Q000379:methods*; D012046:Rehabilitation / Q000379:methods*; D012107:Research Design; D057170:Translational Research, Biomedical / Q000379:methods*