[Plasmatic lipid profile indicators related to insulin resistance].
OBJECTIVE
To investigate the effectiveness of biochemical indicators from the plasmatic lipid profile to identify the insulin resistance (IR), assessed by the HOMA-IR index (Homeostasis Model Assessment -Insulin Resistance).


METHODS
138 healthy men (20-59 years) were evaluated. The lipid profile biochemical indicators analyzed were the following: triglycerides (TG), total cholesterol (TC), HDL-C, LDL-C, and TC/HDL-C and TG/HDL-C ratios. The percentile 75 was considered as the cut-off point for IR. Statistical analysis consisted of Spearman correlation coefficient, ROC curves and calculation of the areas under the curve (AUC).


RESULTS
The TG/HDL-C ratio showed the strongest correlation and the greatest AUC (r = 0.334 and AUC = 0.724 +/- 0.046, p < 0.001) respectively, followed by the HDL-C (r = -0.313 and AUC = 0.716 +/- 0.052, p < 0.01), the TG (r = 0.261 and AUC = 0.048 +/- 0.674, p < 0.01) and CT/HDL-C ratio (r = 0.259 and AUC = 0.655 +/- 0.05, p < 0.01). Results for TC and LDL-C showed no statistical significant (p > 0.05).


CONCLUSIONS
The TG/HDL-C ratio showed the greatest ability to identify IR, proved to be an alternative and easy access instrument to assess IR in clinical practice, therefore providing diseases prevention for the adult male population.
Vasques
Ana Carolina Junqueira
AC
Laboratório de Investigação em Metabolismo e Diabetes - Gastrocentro, Universidade Estadual de Campinas, Campinas, SP.
Rosado
Lina Enriqueta Frandsen Paez de Lima
LE
Rosado
Gilberto Paixão
GP
Ribeiro
Rita de Cassia Lanes
Rde C
Franceschini
Sylvia do Carmo Castro
Sdo C
Priore
Silvia Eloiza
SE
Geloneze
Bruno
B
Oliveira
Dirce Ribeiro de
DR
D000328:Adult; D015415:Biomarkers / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D004812:Epidemiologic Methods; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
D015415:Biomarkers; D008076:Cholesterol, HDL; D008055:Lipids; D014280:Triglycerides