One-pot synthesis of 4,5-biphenyl-2-pyrimidinylguanidine derivatives.
A simple and straightforward methodology toward the synthesis of novel 4,5-biphenyl-2-pyrimidinylguanidine compounds has been developed by one-pot reaction of biguaninde or dimethyldiguanide with isoflavones. A series of 20 new compounds was reported. All of them were characterized by FT-IR, NMR, and elemental analysis. A typical compound was determined by X-ray diffraction. A variety of substrates can participate in the process with good yields and high purities, making this methodology suitable for library synthesis in drug discovery.
Zhang
Zun-Ting
ZT
Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, and School of Chemistry and Materials Science, Shaanxi Normal University, Xi'an 710062, PR China. zhangzt@snnu.edu.cn
Xu
Fei-Fei
FF
Gao
Mi-Xiang
MX
Qiu
Li
L
D006146:Guanidines / Q000138:chemical synthesis* / Q000737:chemistry; D007529:Isoflavones / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009287:Naphthyridines / Q000138:chemical synthesis*; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
D006146:Guanidines; D007529:Isoflavones; D009287:Naphthyridines; C545233:pyrimido(4,5-b)(1,6)naphthyridine