title: Detection of tulobuterol crystal in transdermal patches using terahertz pulsed spectroscopy and imaging.
abstract: Applicability of a Terahertz Pulsed Spectroscopy (TPS) and a Terahertz Pulsed Imaging (TPI) for detection of tulobuterol (TBR) crystals in transdermal patches was investigated. Because TBR has high permeability in dermis, crystalline TBR in patch matrices contributes to controlling the release rate of TBR from a matrix. Therefore, crystalline TBR is one of the important factors for quality control of TBR transdermal tapes. A model tape that includes 5 w/w%, 10 w/w%, 20 w/w% or 30 w/w% of TBR was measured by TPS/TPI. TBR crystals in the matrices were successfully detected by TPI. Identification of TBR in an image of a crystal-like mass was done by comparison between the spectra of tapes and a TBR standard substance. These results indicate that TPS and TPI are applicable to identifying crystalline lumps of an active drug in tapes for quality control.
authors.affiliation: Division of Drugs, National Institute of Health Sciences, 1-18-1, Kami-yoga, Setagaya-ku, Tokyo 158-8501, Japan. tsakamot@nihs.go.jp
authors.forename: T
authors.initials: T
authors.lastname: Sakamoto
authors.forename: A
authors.initials: A
authors.lastname: Portieri
authors.forename: P F
authors.initials: PF
authors.lastname: Taday
authors.forename: Y
authors.initials: Y
authors.lastname: Takada
authors.forename: D
authors.initials: D
authors.lastname: Sasakura
authors.forename: K
authors.initials: K
authors.lastname: Aida
authors.forename: T
authors.initials: T
authors.lastname: Matsubara
authors.forename: T
authors.initials: T
authors.lastname: Miura
authors.forename: T
authors.initials: T
authors.lastname: Terahara
authors.forename: D D
authors.initials: DD
authors.lastname: Arnone
authors.forename: T
authors.initials: T
authors.lastname: Kawanishi
authors.forename: Y
authors.initials: Y
authors.lastname: Hiyama
mesh_terms: D000279:Administration, Cutaneous; D000318:Adrenergic beta-Agonists / Q000008:administration & dosage / Q000737:chemistry*; D003460:Crystallization; D010316:Particle Size; D013057:Spectrum Analysis; D053832:Surgical Tape; D013607:Tablets; D013726:Terbutaline / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry
chemical_list: D000318:Adrenergic beta-Agonists; D013607:Tablets; C010809:tulobuterol; D013726:Terbutaline