title: Transcultural adaptation and psychometric validation of a French-language version of the QoL-AD.
abstract: OBJECTIVE
  The aim of this study was to assess the psychometric properties and the transcultural adaptation into French of the quality-of-life in Alzheimer's disease (QoL-AD).
  
  
  METHODS
  A total of 120 patient-proxy pairs were recruited in six French hospitals and one French-speaking Swiss hospital to take part in the study. The patients presented mild to moderate AD (MMSE > or = 10). The QoL-AD was administered by an interviewer for patients and was self-administered for caregiver proxies. Thus, the psychometric validation enabled the study of feasibility, acceptability, reliability and convergent and discriminant validity of the instrument.
  
  
  RESULTS
  The French version of the QoL-AD showed good internal consistency (Cronbach's alpha coefficient > or = 0.70) and good reliability (Intra-class correlation > 0.80) at a 2-week interval, for patient and caregiver questionnaires. Convergent validity, as indicated by correlation between the QoL-AD (disease-specific instrument) and the dimensions of the Duke Health Profile (generic instrument), was also good for eight dimensions in the Duke profile (p < 0.05). Discriminant validity showed a significant difference for depression (p = 0.0025) and did not show significant difference for two groups of dementia (p = 0.11).
  
  
  CONCLUSIONS
  There is now a validated French version of the QoL-AD available, following transcultural adaptation according to international recommendations, which possesses good psychometric qualities.
authors.affiliation: University of Reims Champagne-Ardenne, Reims F-51095, France.
authors.forename: Aurore
authors.initials: A
authors.lastname: Wolak
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Novella
authors.forename: Moustapha
authors.initials: M
authors.lastname: Drame
authors.forename: Francis
authors.initials: F
authors.lastname: Guillemin
authors.forename: Laura
authors.initials: L
authors.lastname: Di Pollina
authors.forename: Joël
authors.initials: J
authors.lastname: Ankri
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Aquino
authors.forename: Isabella
authors.initials: I
authors.lastname: Morrone
authors.forename: François
authors.initials: F
authors.lastname: Blanchard
authors.forename: Damien
authors.initials: D
authors.lastname: Jolly
mesh_terms: D000203:Activities of Daily Living / Q000523:psychology; D000223:Adaptation, Psychological; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000523:psychology*; D003431:Cross-Cultural Comparison; D005260:Female; D005602:France; D006801:Humans; D007802:Language; D008297:Male; D011594:Psychometrics / Q000706:statistics & numerical data; D011788:Quality of Life / Q000523:psychology*; D015203:Reproducibility of Results; D011795:Surveys and Questionnaires