title: Sequence-specific (1)H, (13)C, and (15)N backbone assignment of the 28 kDa PDZ2/PDZ3 tandem domain of the protein tyrosine phosphatase PTP-BL.
abstract: Protein tyrosine phosphatase-basophil like (PTP-BL) represents a large multi domain non-transmembrane scaffolding protein that contains five PDZ domains. Here we report the backbone assignments of the PDZ2/PDZ3 tandem domain of PTP-BL. These assignments now provide a basis for the detailed structural investigation of the interaction between the PDZ domains 2 and 3 of PTP-BL. It will lead to a better understanding of the proposed scaffolding function of this tandem domain in multi-protein complexes assembled by PTB-BL.
authors.affiliation: Ruhr-University of Bochum, Germany.
authors.forename: Christian P
authors.initials: CP
authors.lastname: Fetzer
authors.forename: Janelle
authors.initials: J
authors.lastname: Sauvageau
authors.forename: Gerd
authors.initials: G
authors.lastname: Kock
authors.forename: Carsten
authors.initials: C
authors.lastname: Berghaus
authors.forename: Jan-Amadé
authors.initials: JA
authors.lastname: Bangert
authors.forename: Markus
authors.initials: M
authors.lastname: Dicks
authors.forename: Rolf
authors.initials: R
authors.lastname: Heumann
authors.forename: Kai S
authors.initials: KS
authors.lastname: Erdmann
authors.forename: Raphael
authors.initials: R
authors.lastname: Stoll
mesh_terms: D000595:Amino Acid Sequence; D002247:Carbon Isotopes / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008970:Molecular Weight; D009587:Nitrogen Isotopes / Q000737:chemistry; D017434:Protein Structure, Tertiary; D054595:Protein Tyrosine Phosphatase, Non-Receptor Type 13 / Q000737:chemistry*; D011522:Protons
chemical_list: D002247:Carbon Isotopes; D009587:Nitrogen Isotopes; D011522:Protons; D054595:Protein Tyrosine Phosphatase, Non-Receptor Type 13