title: Effect of reactive hyperemia on carotid-radial pulse wave velocity in hypertensive participants and direct comparison with flow-mediated dilation: a pilot study.
abstract: This pilot study assessed the effects of hyperemia on carotid-radial pulse wave velocity (PWV) in 39 normotensive (NT) and 23 hypertensive (HT) participants using applanation tonometry. Pulse wave velocity was measured at 1- and at 2-minute intervals. Baseline PWV was similar between the groups (P = .59). At 1 minute, PWV decreased (8.5 +/- 1.2 to 7.1 +/- 1.4 m/s, P < .001) in NT but not in HT (P = .83). Hyperemic PWV (DeltaPWV) response differed between the groups (-16% vs + 1.0%, P < .001). On multivariate analysis, HT, not age or blood pressure was independently related to DeltaPWV (R(2) = .43, P < .01). Among patients with cardiovascular risk factors/disease, DeltaPWV was inversely related to flow-mediated dilation (FMD; R( 2) = .43, P < .003).
  
  
  CONCLUSIONS
  hyperemia decreases PWV(1min) in NT but not in HT. DeltaPWV is inversely related to FMD. Blunted hyperemic PWV response may represent impaired vasodilatory reserve.
authors.affiliation: Division of Cardiovascular Medicine, State University of New York Downstate Medical Center, Brooklyn, New York 11203, USA.
authors.forename: Haroon
authors.initials: H
authors.lastname: Kamran
authors.forename: Louis
authors.initials: L
authors.lastname: Salciccioli
authors.forename: Eun Hee
authors.initials: EH
authors.lastname: Ko
authors.forename: Ghazanfar
authors.initials: G
authors.lastname: Qureshi
authors.forename: Haris
authors.initials: H
authors.lastname: Kazmi
authors.forename: John
authors.initials: J
authors.lastname: Kassotis
authors.forename: Jason
authors.initials: J
authors.lastname: Lazar
mesh_terms: D000328:Adult; D001916:Brachial Artery / Q000503:physiopathology; D002339:Carotid Arteries / Q000503:physiopathology*; D006801:Humans; D006940:Hyperemia / Q000503:physiopathology*; D006973:Hypertension / Q000503:physiopathology*; D008875:Middle Aged; D010865:Pilot Projects; D011446:Prospective Studies; D011674:Pulse; D017534:Radial Artery / Q000503:physiopathology*