RIP kinases at the crossroads of cell death and survival.
Protein kinases of the receptor interacting protein (RIP) family collaborate with death receptor proteins to regulate cell death. Recent studies (Cho et al., 2009; He et al., 2009; Zhang et al., 2009) reveal that the RIP3 kinase functions with RIP1 at the crossroads of apoptosis, necroptosis, and cell survival.
Declercq
Wim
W
Molecular Signaling and Cell Death Unit, Department for Molecular Biomedical Research, VIB, 9052 Ghent, Belgium.
Vanden Berghe
Tom
T
Vandenabeele
Peter
P
D000818:Animals; D016923:Cell Death; D002470:Cell Survival; D006801:Humans; D051379:Mice; D028861:Nuclear Pore Complex Proteins / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000378:metabolism; D053422:Receptor-Interacting Protein Serine-Threonine Kinases / Q000378:metabolism*; D015398:Signal Transduction
C119724:AGFG1 protein, human; D028861:Nuclear Pore Complex Proteins; D016601:RNA-Binding Proteins; C119705:RIPK3 protein, human; D053422:Receptor-Interacting Protein Serine-Threonine Kinases