title: Paradoxical long-term enhancement of distortion product otoacoustic emission amplitude after repeated exposure to moderate level, wide band noise in awake guinea pigs.
abstract: OBJECTIVE
  Hearing sensitivity usually diminishes with noise exposure. In the present study, we examined the effect of 93 dB(A) wide band noise on cochlear micromechanical sensitivity in awake guinea pigs.
  
  
  METHODS
  Animals were randomly assigned to groups receiving either single or repeated noise exposure. Distortion product otoacoustic emission amplitudes were recorded before, during and after noise exposure.
  
  
  RESULTS
  Ninety-three decibel(A) wide band noise reduced the distortion product otoacoustic emission amplitudes at all tested frequencies. The distortion product otoacoustic emission amplitudes for higher frequencies showed a permanent reduction, whereas those for lower frequencies showed a temporary reduction. Distortion product otoacoustic emission amplitudes for middle frequencies showed prolonged enhancement after repeated noise exposure.
  
  
  CONCLUSIONS
  Our results suggest that (1) it is likely that there are intermediate stages between permanent threshold shift and temporary threshold shift, and (2) long-term enhancement of distortion product otoacoustic emission amplitudes may be an indication of tinnitus generation.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital, Wuhan University, China.
authors.forename: L
authors.initials: L
authors.lastname: Mei
authors.forename: Z-W
authors.initials: ZW
authors.lastname: Huang
authors.forename: Z-Z
authors.initials: ZZ
authors.lastname: Tao
mesh_terms: D000818:Animals; D003051:Cochlea / Q000502:physiology*; D004195:Disease Models, Animal; D006168:Guinea Pigs; D006309:Hearing; D006317:Hearing Loss, Noise-Induced / Q000209:etiology*; D009622:Noise / Q000009:adverse effects*; D017084:Otoacoustic Emissions, Spontaneous / Q000502:physiology*; D011897:Random Allocation; D013223:Statistics as Topic; D013997:Time Factors