Amyloid + activation = Alzheimer's?
PET imaging of Alzheimer's disease (AD) patients demonstrates Abeta-protein accumulation in a default mode network. In this issue of Neuron, Sperling and colleagues show that cognitively intact individuals with Abeta in this network fail to deactivate it during memory tasks, a finding with important implications for cognitive aging and early detection of AD.
Jagust
William
W
Helen Wills Neuroscience Institute, University of California, Berkeley, 132 Barker Hall, Berkeley, CA 94720-3190, USA. jagust@berkeley.edu
D000375:Aging; D000544:Alzheimer Disease / Q000000981:diagnostic imaging* / Q000503:physiopathology* / Q000523:psychology; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology*; D003071:Cognition; D006801:Humans; D008279:Magnetic Resonance Imaging; D008568:Memory; D009483:Neuropsychological Tests; D049268:Positron-Emission Tomography
D016229:Amyloid beta-Peptides