Antifatigue activity of phenylethanoid-rich extract from Cistanche deserticola.
A phenylethanoid-rich extract (ECD) of Cistanche deserticola Y.C. Ma, a holoparasitic plant and a valuable traditional Chinese medicine, was evaluated for antifatigue activity in ICR mice. ECD (0.25, 0.50, 1.00 g/kg) was administered orally to mice for 3 weeks. The swimming time to exhaustion was longer in the treatment groups (0.50, 1.00 g/kg) than in the control group (p < 0.01). The serum creatine kinase, lactate dehydrogenase and lactic acid levels were decreased significantly in the treatment groups compared with the control group, while the contents of hemoglobin and glucose were increased significantly. In conclusion, ECD appeared to enhance the swimming capacity of mice by decreasing muscle damage, delaying the accumulation of lactic acid and by improving the energy storage. These results provide scientific evidence for the traditional Chinese medical practice of C. deserticola.
Cai
Run-Lan
RL
Institute of Medicinal Plant Development, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, PR China.
Yang
Mei-Hua
MH
Shi
Yue
Y
Chen
Jun
J
Li
Yong-Chao
YC
Qi
Yun
Y
D000818:Animals; D001786:Blood Glucose; D031671:Cistanche / Q000737:chemistry*; D003402:Creatine Kinase / Q000097:blood; D004365:Drugs, Chinese Herbal / Q000494:pharmacology; D005221:Fatigue / Q000188:drug therapy*; D006003:Glycogen / Q000032:analysis; D006454:Hemoglobins / Q000032:analysis; D007770:L-Lactate Dehydrogenase / Q000097:blood; D019344:Lactic Acid / Q000097:blood; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D018482:Muscle, Skeletal / Q000378:metabolism; D010807:Physical Endurance / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*; D013550:Swimming
D001786:Blood Glucose; D004365:Drugs, Chinese Herbal; D006454:Hemoglobins; D010936:Plant Extracts; D019344:Lactic Acid; D006003:Glycogen; D007770:L-Lactate Dehydrogenase; D003402:Creatine Kinase