[Anti-inflammatory and analgesic potency of carboxyamidotriazole, a tumoristatic agent].
OBJECTIVE
To explore the potential anti-inflammatory and analgesic activities of carboxyamidotriazole (CAI).


METHODS
A variety of animal models, including the croton oil-induced ear edema, the cotton-induced granuloma, the rat adjuvant-induced arthritis, were used to evaluate anti-inflammatory effect of CAI. Vascular endothelial growth factor (VEGF)--or histamine-stimulated local vascular permeability in mouse modulated by CAI was also determined. In addition, we assessed the effect of CAI on the levels of proinflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-beta) at the site of inflammation and in sera. Moreover, antinociceptive effect of CAI on inflammatory pain was assessed using acetic acid-induced writhing model and the formalin test.


RESULTS
CAI significantly inhibited acute and chronic phases of inflammation, reduced VEGF or histamine-induced vascular permeability, and showed marked inhibition of proinflammatory cytokines such as TNF-alpha and IL-1 beta. CAI also showed potential therapeutic effect on peripheral inflammatory pain.


CONCLUSIONS
CAI is a promising anti-inflammatory and analgesic agent.
Guo
Lei
L
Department of Pharmacology, Institute of Basic Medical Sciences, CAMS and PUMC, Beijing 100005, China.
Li
Juan
J
Ye
Hua
H
Zheng
Ru
R
Hao
Xiao-Jian
XJ
Chen
Wen-Ying
WY
Jü
Rui
R
Yao
Yi-Ren
YR
Yang
Hui-Fen
HF
Yu
Xiao-Li
XL
Ye
Cai-Ying
CY
Zhang
De-Chang
DC
D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D005260:Female; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D051381:Rats; D017208:Rats, Wistar; D014230:Triazoles / Q000494:pharmacology*
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D014230:Triazoles; C062058:carboxyamido-triazole