title: Growth patterns in children with intrauterine growth retardation and their correlation to neurocognitive development.
abstract: The relationship between somatic growth and neurocognitive outcome was studied in a cohort of 136 children with intrauterine growth retardation. The children were followed up from birth to 9 to 10 years of age by annual measurements of growth parameters, neurodevelopmental evaluations, and IQ. The rate of catch-up for height between 1 and 2 years of age was significantly higher than the catch-up for weight (P < .001). The cognitive outcome at 9 to 10 years correlated with head circumference at all ages. The neurodevelopmental outcome at 9 to 10 years correlated with weight at all ages. Correlation with head circumference was more significant with IQ, while with weight it was stronger with the neurodevelopmental score. Height at 1 year was a significant predictor for IQ and neurodevelopmental outcome at 9 to 10 years. These findings are of distinct importance for prediction of subsequent neurodevelopmental outcome in children with intrauterine growth retardation.
authors.affiliation: Institute for Child Development and Pediatric Neurology Unit, Tel Aviv Sourasky Medical Center affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Israel. afatal@post.tau.ac.il
authors.forename: Aviva
authors.initials: A
authors.lastname: Fattal-Valevski
authors.forename: Hagit
authors.initials: H
authors.lastname: Toledano-Alhadef
authors.forename: Yael
authors.initials: Y
authors.lastname: Leitner
authors.forename: Ronny
authors.initials: R
authors.lastname: Geva
authors.forename: Rina
authors.initials: R
authors.lastname: Eshel
authors.forename: Shaul
authors.initials: S
authors.lastname: Harel
mesh_terms: D001827:Body Height; D001835:Body Weight; D002508:Cephalometry; D002648:Child; D002657:Child Development; D002675:Child, Preschool; D003071:Cognition; D005317:Fetal Growth Retardation; D005500:Follow-Up Studies; D005865:Gestational Age; D006257:Head / Q000254:growth & development; D006801:Humans; D007223:Infant; D007230:Infant, Low Birth Weight / Q000254:growth & development* / Q000523:psychology*; D007231:Infant, Newborn; D007360:Intelligence; D007361:Intelligence Tests; D009483:Neuropsychological Tests; D011446:Prospective Studies