Globulixanthone F, a new polyoxygenated xanthone with an isoprenoid group and two antimicrobial biflavonoids from the stem bark of Symphonia globulifera.
Bioassay-guided fractionation of the stem bark of Symphonia globulifera has yielded three known xanthones, ugaxanthone (1), mbarraxanthone (2) and gentisein (3), two biflavonoid derivatives named GB2 (4) and manniflavanone GB3 (5), and one new polyoxygenated xanthone with an isoprenoid group, named globulixanthone F (6). The structures of these compounds were elucidated by means of spectroscopic methods. The spectral data of 1 and 2 are reported here for the first time, as well as the antimicrobial activity of globulixanthone F against a range of microorganisms. We also report the total synthesis of the xanthone skeleton.
Mkounga
Pierre
P
Department of Organic Chemistry, Faculty of Science, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon. mpierrendi@yahoo.fr
Fomum
Zacharias T
ZT
Meyer
Michèle
M
Bodo
Bernard
B
Nkengfack
Augustin E
AE
D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D028084:Clusiaceae / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D008967:Molecular Biology; D024301:Plant Bark / Q000737:chemistry*; D044004:Xanthones / Q000737:chemistry*
D000890:Anti-Infective Agents; D005419:Flavonoids; D044004:Xanthones; C543281:globulixanthone F