[TNF alfa polymorphism and course of ulcerative colitis].
Inflammatory bowel diseases including ulcerative colitis are associated with prolonged inflammatory process, that is dependent on cytokine production. Among them crucial role plays tumor necrosis factor TNF-alpha. There is proven association between single nucleotyde polimorphism and ability to produce cytokines.


OBJECTIVE
We analyzed association between TNF-alpha (-308) promoter polymorphism and extension of lesions in ulcerative colitis. TNF-alpha (-308) promoter polymorphism.


METHODS
Analysis was performed using polymerase chain reaction with sequence specific primers method (PCR-SSP) in 48 patients suffering from ulcerative colitis and association between TNF-alpha (-308) promoter polymorphism and ulcerative colitis macroscopic lesions classified according Montreal classification was investigated.


RESULTS
No statistically significant association among groups of patients and TNF-alpha (-308) promoter polymorphism was observed. More cases of TNF-alpha (-308) promoter polymorphism associated with low TNF-alpha production were observed in patients with E2 and E3 lesions according to Montreal classification. CONCLUSIONS. There is no direct association between TNF-alpha (-308) promoter polymorphism and ulcerative colitis macroscopic inflammatory lesions evaluated on basis of Montreal classification. There is statistically irrelevant tendency of more cases of pancolitis in group of patient with TNF-alpha (-308) promoter polymorphism associated with low TNF-alpha production.
Jałocha
Łukasz
Ł
Military Institute of Health Service in Warsaw, Departament of Gastroenterology, Central Clinical Hospital of the Ministry of National Defense. ljalocha@yahoo.com
Wojtuń
Stanisław
S
Dyrla
Przemysław
P
Gil
Jerzy
J
Korsak
Jolanta
J
Rzeszotarska
Agnieszka
A
Fiedorowicz
Ewa
E
D003093:Colitis, Ulcerative / Q000235:genetics* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis / Q000235:genetics*
D014409:Tumor Necrosis Factor-alpha