title: [Plasmatic lipid profile indicators related to insulin resistance].
abstract: OBJECTIVE
  To investigate the effectiveness of biochemical indicators from the plasmatic lipid profile to identify the insulin resistance (IR), assessed by the HOMA-IR index (Homeostasis Model Assessment -Insulin Resistance).
  
  
  METHODS
  138 healthy men (20-59 years) were evaluated. The lipid profile biochemical indicators analyzed were the following: triglycerides (TG), total cholesterol (TC), HDL-C, LDL-C, and TC/HDL-C and TG/HDL-C ratios. The percentile 75 was considered as the cut-off point for IR. Statistical analysis consisted of Spearman correlation coefficient, ROC curves and calculation of the areas under the curve (AUC).
  
  
  RESULTS
  The TG/HDL-C ratio showed the strongest correlation and the greatest AUC (r = 0.334 and AUC = 0.724 +/- 0.046, p < 0.001) respectively, followed by the HDL-C (r = -0.313 and AUC = 0.716 +/- 0.052, p < 0.01), the TG (r = 0.261 and AUC = 0.048 +/- 0.674, p < 0.01) and CT/HDL-C ratio (r = 0.259 and AUC = 0.655 +/- 0.05, p < 0.01). Results for TC and LDL-C showed no statistical significant (p > 0.05).
  
  
  CONCLUSIONS
  The TG/HDL-C ratio showed the greatest ability to identify IR, proved to be an alternative and easy access instrument to assess IR in clinical practice, therefore providing diseases prevention for the adult male population.
authors.affiliation: Laboratório de Investigação em Metabolismo e Diabetes - Gastrocentro, Universidade Estadual de Campinas, Campinas, SP.
authors.forename: Ana Carolina Junqueira
authors.initials: AC
authors.lastname: Vasques
authors.forename: Lina Enriqueta Frandsen Paez de Lima
authors.initials: LE
authors.lastname: Rosado
authors.forename: Gilberto Paixão
authors.initials: GP
authors.lastname: Rosado
authors.forename: Rita de Cassia Lanes
authors.initials: Rde C
authors.lastname: Ribeiro
authors.forename: Sylvia do Carmo Castro
authors.initials: Sdo C
authors.lastname: Franceschini
authors.forename: Silvia Eloiza
authors.initials: SE
authors.lastname: Priore
authors.forename: Bruno
authors.initials: B
authors.lastname: Geloneze
authors.forename: Dirce Ribeiro de
authors.initials: DR
authors.lastname: Oliveira
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D004812:Epidemiologic Methods; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
chemical_list: D015415:Biomarkers; D008076:Cholesterol, HDL; D008055:Lipids; D014280:Triglycerides