Retrocollis, anterocollis or head tremor may predict the spreading of dystonic movements in primary cervical dystonia.
OBJECTIVE
Few studies have attempted to develop clinical predictors for cervical dystonia (CD) aiming at progression of the dystonic movement.


METHODS
We retrospectively evaluated 73 patients with primary CD who underwent treatment with Botulinum toxin type-A (BTX-A). The patients were assembled in two groups according to the spread of dystonia during follow-up: spreading and non-spreading CD. We performed a binary logistic regression model using spreading of cervical dystonia as dependent variable aiming to find covariates which increase the risk of spreading.


RESULTS
Our logistic regression model found the following covariates and their respective risk ratios: time of disease >18.5 months=2.4, retrocollis=1.9, anterocollis=1.8, head tremor=1.6.


CONCLUSIONS
Time of disease >18.5 months, retrocollis, anterocollis and head tremor may predict spreading of dystonic movement to other regions of the body in CD patients.
Godeiro-Junior
Clecio
C
Movement Disorders Unit, Department of Neurology and Neurosurgery, Federal University of São Paulo, São Paulo, SP, Brazil. cleciojunior@yahoo.com.br
Felício
Andre Carvalho
AC
Aguiar
Patrícia Maria de Carvalho
PM
Borges
Vanderci
V
Silva
Sonia Maria Azevedo
SM
Ferraz
Henrique Ballalai
HB
D000328:Adult; D019274:Botulinum Toxins, Type A / Q000627:therapeutic use; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D009465:Neuromuscular Agents / Q000627:therapeutic use; D012189:Retrospective Studies; D014103:Torticollis / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*; D014202:Tremor / Q000503:physiopathology*
D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A