Design, synthesis and antifungal activity of a series of novel analogs based on diphenyl ketones.
To find potent fungicides, 35 analogs of diphenyl ketones were synthesized and evaluated for their antifungal activity. These compounds possessed a furyl-carbonyl-phenyl skeleton. Bioassay results showed that the synthesized compounds were effective in promoting the antifungal activity of diphenyl ketones. Compound 3 showed the best activity against the four tested fungi (100%, 100%, 100% and 96.4%) and could be used as potent fungicide for further research.
Liu
Wei
W
Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, China.
Shi
Hui-Min
HM
Jin
Hong
H
Zhao
Hao-Yu
HY
Zhou
Guo-Ping
GP
Wen
Fang
F
Yu
Zhi-Yi
ZY
Hou
Tai-Ping
TP
D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015195:Drug Design; D005658:Fungi / Q000187:drug effects*; D005663:Furans / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D007659:Ketones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests
C544205:1-(2-furyl)-3-(2-furyl)-2-propen-1-one; D000935:Antifungal Agents; D005663:Furans; D007659:Ketones