title: Focus issue: unraveling signaling complexity.
abstract: The biochemical processes that control the responses of cells to changes in their internal or external environments form a complex interconnected network. The molecules that participate in these processes are diverse and dynamic, and the networks themselves are affected by the flow of information through them. With this appreciation of the complexity in signaling networks, Science Signaling highlights computational and experimental approaches to understanding both the macroscopic cellular response and the microscopic signaling network and its constituents and dynamics.
authors.forename: Nancy R
authors.initials: NR
authors.lastname: Gough
authors.forename: John F
authors.initials: JF
authors.lastname: Foley
mesh_terms: D000818:Animals; D006801:Humans; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism*; D010766:Phosphorylation; D011948:Receptors, Antigen, T-Cell / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D013601:T-Lymphocytes / Q000166:cytology / Q000378:metabolism
chemical_list: D011948:Receptors, Antigen, T-Cell; D020928:Mitogen-Activated Protein Kinases