title: Antinociceptive activity of the essential oil of Zingiber zerumbet.
abstract: In the present study, the rhizome essential oil from Zingiber zerumbet (Zingiberaceae) was evaluated for antinociceptive activity using chemical and thermal models of nociception, namely, the acetic acid-induced abdominal writhing test, the hot-plate test and the formalin-induced paw licking test. It was demonstrated that intraperitoneal administration of the essential oil of Z. zerumbet (EOZZ) at the doses of 30, 100 and 300 mg/kg produced significant dose-dependent inhibition of acetic acid-induced abdominal writhing, comparable to that of obtained with acetylsalicylic acid (100 mg/kg). At the same doses, the EOZZ produced significant dose-dependent increases in the latency time in the hot-plate test with respect to controls, and in the formalin-induced paw licking test, the EOZZ also significantly reduced the painful stimulus in both neurogenic and inflammatory phase of the test. In addition, the antinociceptive effect of the EOZZ in the formalin-induced paw licking test as well as hot-plate test was reversed by the nonselective opioid receptor antagonist, naloxone suggesting that the opioid system was involved in its analgesic mechanism of action. On the basis of these data, we concluded that the EOZZ possessed both central and peripheral antinociceptive activities which justifying its popular folkloric use to relieve some pain conditions.
authors.affiliation: Department of Biomedical Science, University Putra Malaysia, Serdang, Malaysia. mrs@medic.upm.edu.my
authors.forename: Mohd Roslan
authors.initials: MR
authors.lastname: Sulaiman
authors.forename: Tengku Azam Shah
authors.initials: TA
authors.lastname: Tengku Mohamad
authors.forename: Wan Mastura
authors.initials: WM
authors.lastname: Shaik Mossadeq
authors.forename: Saidi
authors.initials: S
authors.lastname: Moin
authors.forename: Mazina
authors.initials: M
authors.lastname: Yusof
authors.forename: Ahmad Fauzi
authors.initials: AF
authors.lastname: Mokhtar
authors.forename: Zainul Amiruddin
authors.initials: ZA
authors.lastname: Zakaria
authors.forename: Daud Ahmad
authors.initials: DA
authors.lastname: Israf
authors.forename: Nordin
authors.initials: N
authors.lastname: Lajis
mesh_terms: D019342:Acetic Acid; D000700:Analgesics / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005557:Formaldehyde; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009270:Naloxone / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000494:pharmacology; D009822:Oils, Volatile / Q000008:administration & dosage / Q000627:therapeutic use*; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy*; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011930:Reaction Time / Q000187:drug effects; D011957:Receptors, Opioid / Q000378:metabolism; D027343:Rhizome; D030521:Zingiberaceae / Q000737:chemistry*
chemical_list: D000700:Analgesics; D009292:Narcotic Antagonists; D009822:Oils, Volatile; D010936:Plant Extracts; D011957:Receptors, Opioid; D005557:Formaldehyde; D009270:Naloxone; D019342:Acetic Acid