title: Isopimarane diterpenoids from Aeollanthus rydingianus and their antimicrobial activity.
abstract: Four acyloxy-isopimarane derivatives along with two known isopimarane diterpenoids, the flavone cirsimaritin and the sterols beta-sitosterol and stigmasterol were isolated from the aerial parts of Aeollanthus rydingianus. The structures of the compounds were established on the basis of spectroscopic analysis and chemical evidence. The isolated substances were screened for antimicrobial activity against Gram-positive and Gram-negative bacteria and a yeast strain. 19-Acetoxy-7,15-isopimaradien-3beta-ol and 7,15-isopimaradien-19-ol showed minimum inhibitory concentration (MIC) values of 3.90-15.62 microg/ml for Staphylococcus aureus and of 7.81microg/ml for Enterococcus hirae.
authors.affiliation: Faculdade de Farmácia da Universidade de Lisboa, iMed. UL, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal.
authors.forename: Patricia
authors.initials: P
authors.lastname: Rijo
authors.affiliation: Faculdade de Farmácia da Universidade de Lisboa, iMed. UL, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal.
authors.forename: Maria Fátima
authors.initials: MF
authors.lastname: Simões
authors.affiliation: Faculdade de Farmácia da Universidade de Lisboa, iMed. UL, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal.
authors.forename: Aida
authors.initials: A
authors.lastname: Duarte
authors.affiliation: Instituto de Química Orgánica, CSIC, Juan de la Cierva 3, 28006 Madrid, Spain. Electronic address: iqor107@iqog.csic.es.
authors.forename: Benjamín
authors.initials: B
authors.lastname: Rodríguez
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D016983:Enterococcus / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D019686:Lamiaceae / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D012855:Sitosterols; D013211:Staphylococcus aureus / Q000187:drug effects; D014640:Vancomycin / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D004224:Diterpenes; D012855:Sitosterols; C025473:gamma-sitosterol; D014640:Vancomycin