[Comparative studies of hemorheological parameters in Tibet mini-pigs, Beagle dogs and human].
OBJECTIVE
To investigate the relationship of hemorheological parameters between Tibet mini-pigs, Beagle dogs and human.


METHODS
Blood samples were collected from adult Tibet mini-pigs, Beagle dogs and human to detect such hemorheological parameters as the whole blood viscosity (WBV) (high, middle, and low shear rate), PV, HCT, ESR and Fi.


RESULTS
The male Tibet mini-pigs had significantly lower WBV (150, 30, 5, and 1 s(-1)) and Fi than the female mini-pigs (P<0.05, 0.01, 0.05, 0.01, and 0.01, respectively). The WBV of male Beagle dogs (150 and 1 s(-1)) was significantly lower that in than female dogs (P<0.05). The WBV of male human subjects (1 s(-1)) and HCT were significantly higher, but ESR significantly lower than those in female human subjects P<0.05, 0.01 and 0.01, respectively). WBV (1 s(-1)), PV, and ESR in Beagle dogs were significantly lower, but HCT and Fi significantly higher than those in Tibet mini-pig and human subjects (P<0.05, 0.01, 0.05, and 0.01, respectively). All the hemorheological parameters were similar between Tibet mini-pigs and human (P<0.05).


CONCLUSIONS
The hemorheological parameters of Tibet mini-pigs are closer to those of human than those of Beagle dogs.
Yuan
Jin
J
Laboratory Animal Center, Southern Medical University, Guangzhou 510515, China. yjin01@126.com
Wu
Qing-Hong
QH
Chen
Li
L
Zhang
Jia-Ning
JN
Gu
Wei-Wang
WW
D000328:Adult; D000818:Animals; D001799:Blood Sedimentation; D001809:Blood Viscosity; D004285:Dogs; D005260:Female; D006400:Hematocrit; D018056:Hemorheology; D006801:Humans; D008297:Male; D013552:Swine; D013556:Swine, Miniature