[The role of smoking in changing essential parameters in body homeostasis].
Smoking, one of the avoidable causes of mortality, is considered a major risk factor for cardiovascular diseases, chronic obstructive pulmonary diseases, and bronchopulmonary cancer. Many studies suggest that nicotine induces vasoconstriction, not only in coronary arteries but also in peripheral vessels, hypertension, pro-atherogenic effects, due to increase of platelet activation and fatty acids concentration, alterations of endothelial-cell shapes, as well as endothelial-cell proliferation. The main affected vascular biochemical parameters are: endothelin-1, cholesterol, triglycerides, lipoproteins, C-reactive protein, nitric oxide, fibrinogen, and uric acid. Cigarette smoke induces inflammation in respiratory epithelium, through local irritation due to release of oxidants, aldehydes, acids, ammonium; impaired ciliar function, and retention of mucus and toxins, followed by infection; carcinogenesis due to oncogene-expression induced by oxidants, aromatic hydrocarbons, and nitrosamines. These effects are induced by alterations of endothelin-1, nitric oxide, IL1, IL6, TNF, and the CYP Enzyme System. Saliva is the first biological fluid encountered by the cigarette smoke. In vitro and in vivo salivary exposure to cigarette smoke has been shown to determine changes of concentrations of lactate dehydrogenase, amylase, and uric acid, in saliva--important factors of the antioxidant salivary system. Such changes may promote occurrence of upper digestive cancers.
Didilescu
Andreea Cristiana
AC
Catedra de Anatomie si Embriologie, Facultatea de Medicină Dentară, UMF Carol Davila, Bucureşti. Andreea.Didilescu@gmail.com
Hanganu
Stela Carmen
SC
Galie
Nicolae
N
Greabu
Maria
M
Totan
Alexandra
A
Stratul
Stefan Ioan
SI
Puiu
Ligia
L
D015415:Biomarkers / Q000097:blood / Q000378:metabolism*; D002097:C-Reactive Protein / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000139:chemically induced; D002784:Cholesterol / Q000378:metabolism; D019332:Endothelin-1 / Q000378:metabolism; D005340:Fibrinogen / Q000378:metabolism; D006706:Homeostasis / Q000187:drug effects*; D006801:Humans; D008074:Lipoproteins / Q000378:metabolism; D008175:Lung Neoplasms / Q000139:chemically induced; D009569:Nitric Oxide / Q000378:metabolism; D029424:Pulmonary Disease, Chronic Obstructive / Q000139:chemically induced; D020545:Respiratory Mucosa / Q000187:drug effects*; D012307:Risk Factors; D012463:Saliva / Q000187:drug effects / Q000378:metabolism; D012907:Smoking / Q000009:adverse effects* / Q000097:blood / Q000378:metabolism* / Q000503:physiopathology; D014280:Triglycerides / Q000378:metabolism; D014527:Uric Acid / Q000378:metabolism
D015415:Biomarkers; D019332:Endothelin-1; D008074:Lipoproteins; D014280:Triglycerides; D014527:Uric Acid; D009569:Nitric Oxide; D005340:Fibrinogen; D002097:C-Reactive Protein; D002784:Cholesterol