title: Parotid sialosis: morphometrical analysis of the glandular parenchyme and stroma among diabetic and alcoholic patients.
abstract: BACKGROUND
  Among the agents that cause parotid sialosis, diabetes mellitus type 2 and chronic alcoholism are included. In this study, the morphometrical modifications in the diabetic parotid sialosis were determined to compare them with the histopathological characteristics of alcoholic parotid sialosis.
  
  
  METHODS
  Five parotid biopsy samples obtained from patients with diabetic sialosis, 12 samples from patients with alcoholic sialosis and seven from individuals without these pathologies (control group) were analyzed. A morphometrical study of parotid parenchyme and stroma, using a digital image analyzer attached to an optical microscope, was carried out. Dimensions of serous acini and striated ducts, the area occupied by the fatty tissue, and the number of ducts were recorded. Mean values were compared using the Mann-Whitney U-test (P <or= 0.05).
  
  
  RESULTS
  The variables analyzed in diabetic patients did not show significant differences with respect to the control group. However, when diabetics were compared with alcoholics, the alcoholics exhibited a noticeable reduction in the proportion of fatty tissue of stroma and a significant development of ductal epithelium that contributed to increase the caliber of the striated ducts.
  
  
  CONCLUSIONS
  These results indicate that the glandular hypertrophy in the diabetic parotid sialosis is not directly associated with the ductal and acinar size, amount of fatty tissue and ductal hyperplasy. Nevertheless, these findings show that the ductal dimensions and the proportion of adipose tissue are variables that allow us to establish histopathological differences between diabetic and alcoholic sialosis.
authors.affiliation: Cátedra de Morfología Animal, Facultad de Ciencias Exactas, Físicas y Naturales, Universidad Nacional de Córdoba. caromerlo72@hotmail.com
authors.forename: Carolina
authors.initials: C
authors.lastname: Merlo
authors.forename: Luciana
authors.initials: L
authors.lastname: Bohl
authors.forename: Carmen
authors.initials: C
authors.lastname: Carda
authors.forename: María Elsa
authors.initials: ME
authors.lastname: Gómez de Ferraris
authors.forename: Miriam
authors.initials: M
authors.lastname: Carranza
mesh_terms: D000273:Adipose Tissue / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000437:Alcoholism / Q000150:complications*; D001706:Biopsy; D002452:Cell Count; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D004848:Epithelium / Q000473:pathology; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008104:Liver Cirrhosis, Alcoholic / Q000150:complications; D008297:Male; D008853:Microscopy; D008875:Middle Aged; D010305:Parotid Diseases / Q000209:etiology / Q000473:pathology*; D018987:Salivary Ducts / Q000473:pathology