title: Pharmacokinetics of prophylactic micafungin in very-low-birth-weight infants.
abstract: We evaluated the use of micafungin as a prophylaxis in very-low-birth-weight infants. Micafungin was first administered to 25 very-low-birth-weight infants 12 to 24 hours after birth at a dose of 1 mg/kg/d. the apparent volume of distribution, the apparent elimination rate constant, the elimination half-life, and the total body clearance (mean +/- SD) were 0.76 +/- 0.28 L/kg, 0.12 +/- 0.041 1/h, 6.7 +/- 2.2 h, and 0.089 +/- 0.047 L/kg/h, respectively.
authors.affiliation: Department of Pediatrics, Kagawa University, Kita-gun Kagawa, Japan.
authors.forename: Mayumi
authors.initials: M
authors.lastname: Kawada
authors.forename: Noriyasu
authors.initials: N
authors.lastname: Fukuoka
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Kondo
authors.forename: Kaoru
authors.initials: K
authors.lastname: Okazaki
authors.forename: Takashi
authors.initials: T
authors.lastname: Kusaka
authors.forename: Kou
authors.initials: K
authors.lastname: Kawada
authors.forename: Susumu
authors.initials: S
authors.lastname: Itoh
mesh_terms: D000935:Antifungal Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D018890:Chemoprevention / Q000379:methods*; D054714:Echinocandins / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006801:Humans; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight; D055666:Lipopeptides / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000077551:Micafungin; D009181:Mycoses / Q000517:prevention & control*
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D000077551:Micafungin