Chiral Brønsted acid-catalyzed asymmetric Friedel-Crafts alkylation of pyrroles with nitroolefins.
A highly efficient Friedel-Crafts reaction of pyrroles with nitroolefins by a chiral phosphoric acid was realized. With 5 mol % of catalyst, reactions conducted at rt afforded the 2-substituted or 2,5-disubstituted pyrroles in up to 94% ee for a wide range of substrates.
Sheng
Yi-Fei
YF
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China.
Gu
Qing
Q
Zhang
An-Jiang
AJ
You
Shu-Li
SL