[New trends in prognosis and treatment of acute pancreatitis].
Severe acute pancreatitis is common and potentially fatal disease with nonspecific treatment and often unpredictable prognosis. Early, precise discrimination between patients likely and unlikely to have severe pancreatitis would be of great benefit in establishing proper therapy. Evidence based pharmacological treatment of AP is limited and studies on the effect of potent anti-inflammatory drugs are warranted. Experimental data with new anti-inflammatory, and/or immunomodulatory drugs seems to be promising. CRAI (continous regional arterial infusion) with a proteinase inhibitor is a new method for treatment of necrotizing pancreatitis, which needs further evaluation. In this review attention was focused on the progress and new directions in prognosis of severity and treatment of acute pancreatitis.
Rydzewska
Grazyna
G
Gastroenterology Department, Central Clinical Hospital of the Ministry of Internal Affairs and Administration, Warsaw. grazyna.rydzewska@cskmswia.pl
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D004750:Enteral Nutrition; D006801:Humans; D007155:Immunologic Factors / Q000008:administration & dosage; D010195:Pancreatitis / Q000628:therapy*; D019283:Pancreatitis, Acute Necrotizing / Q000188:drug therapy; D019936:Probiotics / Q000627:therapeutic use; D011379:Prognosis; D015842:Serine Proteinase Inhibitors / Q000008:administration & dosage
D000893:Anti-Inflammatory Agents; D007155:Immunologic Factors; D015842:Serine Proteinase Inhibitors