title: Isoprenoids are essential for fruiting body formation in Myxococcus xanthus.
abstract: It was recently shown that Myxococcus xanthus harbors an alternative and reversible biosynthetic pathway to isovaleryl coenzyme A (CoA) branching from 3-hydroxy-3-methylglutaryl-CoA. Analyses of various mutants in these pathways for fatty acid profiles and fruiting body formation revealed for the first time the importance of isoprenoids for myxobacterial development.
authors.affiliation: Molekulare Biotechnologie, Institut für Molekulare Biowissenschaften, Biozentrum/Campus Riedberg, Goethe Universität Frankfurt, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.
authors.forename: Wolfram
authors.initials: W
authors.lastname: Lorenzen
authors.forename: Michael W
authors.initials: MW
authors.lastname: Ring
authors.forename: Gertrud
authors.initials: G
authors.lastname: Schwär
authors.forename: Helge B
authors.initials: HB
authors.lastname: Bode
mesh_terms: D000214:Acyl Coenzyme A / Q000235:genetics / Q000378:metabolism; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D003470:Culture Media; D015964:Gene Expression Regulation, Bacterial; D008798:Mevalonic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D009154:Mutation; D016941:Myxococcus xanthus / Q000235:genetics / Q000254:growth & development* / Q000378:metabolism*; D013729:Terpenes / Q000378:metabolism*
chemical_list: D000214:Acyl Coenzyme A; D001426:Bacterial Proteins; D003470:Culture Media; D013729:Terpenes; C008047:3-hydroxy-3-methylglutaryl-coenzyme A; C017447:isovaleryl-coenzyme A; C015367:mevalonolactone; D008798:Mevalonic Acid