title: Epidemiological studies of cancer in aircrew.
abstract: Exposure to cosmic ionising radiation, in addition to other specific occupational risks, is of concern to aircrew members. Epidemiological studies provide an objective way to assess the health of this occupational group. We systematically reviewed the epidemiological literature on health of aircrew members since 1990, focusing on cancer as the endpoint of interest. Sixty-five relevant publications were identified and reviewed. Whereas overall cancer incidence and mortality was generally lower than in the comparison population, consistently elevated risks were reported for breast cancer incidence in female aircrew members and for melanoma in both male and female aircrew members. Brain cancer was increased in some studies among pilots. Occasionally trends of increasing cancer mortality or incidence with increasing estimated radiation dose were reported. Ionising radiation is considered to contribute little if at all to the elevated risks for cancers among aircrew, whereas excess ultraviolet radiation is a probable cause of the increased melanoma risk.
authors.affiliation: Institute for Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center, Johannes Gutenberg-University, Langenbeckstr. 1, D-55101 Mainz, Germany. hammer@imbei.uni-mainz.de
authors.forename: Gaël P
authors.initials: GP
authors.lastname: Hammer
authors.forename: Maria
authors.initials: M
authors.lastname: Blettner
authors.forename: Hajo
authors.initials: H
authors.lastname: Zeeb
mesh_terms: D000401:Aircraft; D001932:Brain Neoplasms / Q000453:epidemiology / Q000209:etiology; D003359:Cosmic Radiation / Q000009:adverse effects*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D009369:Neoplasms / Q000453:epidemiology* / Q000209:etiology*; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology* / Q000209:etiology; D009784:Occupational Diseases / Q000453:epidemiology* / Q000209:etiology; D016273:Occupational Exposure; D012042:Registries / Q000706:statistics & numerical data; D012306:Risk; D014466:Ultraviolet Rays