Genetic variants at 6p21.33 are associated with susceptibility to follicular lymphoma.
We conducted genome-wide association studies of non-Hodgkin lymphoma using Illumina HumanHap550 BeadChips to identify subtype-specific associations in follicular, diffuse large B-cell and chronic lymphocytic leukemia/small lymphocytic lymphomas. We found that rs6457327 on 6p21.33 was associated with susceptibility to follicular lymphoma (FL; N = 189 cases, 592 controls) with validation in another 456 FL cases and 2,785 controls (combined allelic P = 4.7 x 10(-11)). The region of strongest association overlapped C6orf15 (STG), located near psoriasis susceptibility region 1 (PSORS1).
Skibola
Christine F
CF
Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, California, USA. chrisfs@berkeley.edu
Bracci
Paige M
PM
Halperin
Eran
E
Conde
Lucia
L
Craig
David W
DW
Agana
Luz
L
Iyadurai
Kelly
K
Becker
Nikolaus
N
Brooks-Wilson
Angela
A
Curry
John D
JD
Spinelli
John J
JJ
Holly
Elizabeth A
EA
Riby
Jacques
J
Zhang
Luoping
L
Nieters
Alexandra
A
Smith
Martyn T
MT
Brown
Kevin M
KM
D002896:Chromosomes, Human, Pair 6 / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006801:Humans; D008224:Lymphoma, Follicular / Q000235:genetics*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics