A new look at TCF and beta-catenin through the lens of a divergent C. elegans Wnt pathway.
The canonical Wnt/beta-catenin pathway is extensively characterized, broadly conserved, and clinically important. In this review, we describe the C. elegans Wnt/beta-catenin asymmetry pathway and suggest that some of its unusual features may have important implications for the canonical Wnt/beta-catenin pathway.
Phillips
Bryan T
BT
Department of Biochemistry and Howard Hughes Medical Institute, University of Wisconsin-Madison, Madison, WI 53706-1544, USA. btphillips@wisc.edu
Kimble
Judith
J
D000818:Animals; D017173:Caenorhabditis elegans / Q000502:physiology*; D029742:Caenorhabditis elegans Proteins / Q000235:genetics / Q000378:metabolism*; D016764:Cell Polarity; D005786:Gene Expression Regulation; D006801:Humans; D020928:Mitogen-Activated Protein Kinases / Q000235:genetics / Q000378:metabolism; D008958:Models, Molecular; D010802:Phylogeny; D017434:Protein Structure, Tertiary; D015398:Signal Transduction / Q000502:physiology*; D051820:TCF Transcription Factors / Q000235:genetics / Q000378:metabolism*; D051153:Wnt Proteins / Q000235:genetics / Q000378:metabolism*; D051176:beta Catenin / Q000235:genetics / Q000378:metabolism*
D029742:Caenorhabditis elegans Proteins; D051820:TCF Transcription Factors; D051153:Wnt Proteins; D051176:beta Catenin; D020928:Mitogen-Activated Protein Kinases; C488360:nemo-like kinase, zebrafish