title: The functional promoter polymorphism of the coagulation factor XII gene is not associated with peripheral arterial disease.
abstract: Coagulation factor XII (FXII) plays a key role in both coagulation and fibrinolysis and has been associated with cardiovascular disease in some studies. Plasma FXIIa levels are strongly determined by a common functional polymorphism in the promoter of the FXII gene (F12-4C>T). To investigate the potential association of this polymorphism with peripheral arterial disease (PAD), we performed a case-control study including 668 patients with PAD and 762 controls participants without cardiovascular disease. F12 genotype frequencies were not significantly different between patients with PAD and control participants. After adjustment for classical risk factors, the odds ratio of carriers of a F12 -4T allele for PAD was 1.06 (95% confidence interval 0.86-1.32). F12 genotypes were associated with a modest increase of the mean-activated partial thromboplastin time but not with PAD stage or severity. We conclude that the functional F124C>T polymorphism is not associated with PAD.
authors.affiliation: Division of Rheumatology, Medical University Graz, Austria.
authors.forename: Babak
authors.initials: B
authors.lastname: Yazdani-Biuki
authors.forename: Peter
authors.initials: P
authors.lastname: Krippl
authors.forename: Kerstin
authors.initials: K
authors.lastname: Brickmann
authors.forename: Florentine
authors.initials: F
authors.lastname: Fuerst
authors.forename: Uwe
authors.initials: U
authors.lastname: Langsenlehner
authors.forename: Bernhard
authors.initials: B
authors.lastname: Paulweber
authors.forename: Ernst
authors.initials: E
authors.lastname: Pilger
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Wascher
authors.forename: Hans-Peter
authors.initials: HP
authors.lastname: Brezinschek
authors.forename: Wilfried
authors.initials: W
authors.lastname: Renner
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D005174:Factor XII / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010314:Partial Thromboplastin Time; D016491:Peripheral Vascular Diseases / Q000235:genetics*; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic / Q000235:genetics*; D012307:Risk Factors; D012907:Smoking / Q000453:epidemiology
chemical_list: D005174:Factor XII