title: Selective identification of cooperatively binding fragments in a high-throughput ligation assay enables development of a picomolar caspase-3 inhibitor.
authors.affiliation: Leibniz Institute of Molecular Pharmacology (FMP), Robert-Rössle-Strasse 10, 13125 Berlin, Germany.
authors.forename: Marco F
authors.initials: MF
authors.lastname: Schmidt
authors.forename: Adeeb
authors.initials: A
authors.lastname: El-Dahshan
authors.forename: Sandro
authors.initials: S
authors.lastname: Keller
authors.forename: Jörg
authors.initials: J
authors.lastname: Rademann
mesh_terms: D000447:Aldehydes / Q000737:chemistry* / Q000494:pharmacology; D053148:Caspase 3 / Q000378:metabolism; D061945:Caspase Inhibitors; D015853:Cysteine Proteinase Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D005454:Fluorescence Polarization; D011485:Protein Binding
chemical_list: D000447:Aldehydes; D061945:Caspase Inhibitors; D015853:Cysteine Proteinase Inhibitors; D053148:Caspase 3