Age-dependent changes in calretinin immunoreactivity and its protein level in the gerbil hippocampus.
Calretinin (CR)-immunoreactive interneurons are well known as the interneuron specific interneurons in the hippocampus. CR-immunoreactive neurons form cellular network and regulate the activity of other GABAergic inhibitory interneurons in the hippocampus. In the present study, we investigated age-related changes in CR-immunoreactive neurons and protein levels in the gerbil hippocampus during normal aging. In all subregions of the gerbil hippocampus, the number of CR-immunoreactive neurons was significantly decreased in the postnatal month 6 (PM 6) group compared to that in the PM 1 group. Thereafter, CR-immunoreactive neurons were decreased with age. In addition, the number of CR-immunoreactive cells in the subgranular zone were significantly decreased in the PM 6 group. We also observed that CR protein levels were decreased gradually with age. These results indicate that both CR immunoreactivity and its protein level were decreased with age in the gerbil hippocampus during normal aging.
Lee
Choong Hyun
CH
Department of Anatomy and Neurobiology, and Institute of Neurodegeneration and Neuroregeneration, College of Medicine, Hallym University, Chuncheon 200-702, South Korea.
Hwang
In Koo
IK
Choi
Jung Hoon
JH
Yoo
Ki-Yeon
KY
Park
Ok Kyu
OK
Huh
Sung-Oh
SO
Lee
Yun Lyul
YL
Shin
Hyung-Cheul
HC
Won
Moo-Ho
MH
D000375:Aging / Q000378:metabolism*; D000818:Animals; D064032:Calbindin 2; D005849:Gerbillinae; D006624:Hippocampus / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D064030:S100 Calcium Binding Protein G / Q000378:metabolism*
D064032:Calbindin 2; D009419:Nerve Tissue Proteins; D064030:S100 Calcium Binding Protein G