title: Murine interferon-gamma inducible protein-10 (IP-10) secreted by Lactococcus lactis chemo-attracts human CD3+ lymphocytes.
abstract: Chemokines are members of the super family of cytokines necessary for leukocyte recruitment in tissues and lymphoid organs. The interferon-gamma inducible protein-10 (IP-10) chemo-attracts CXCR3-expressing cells, such as activated T lymphocytes and monocytes. We have genetically engineered a strain of Lactococcus lactis to secrete a biologically active murine IP-10 that interacts with human CXCR3, its homolog receptor, and chemo-attracts human CD3+ T lymphocytes.
authors.affiliation: Departamento de Histología, Universidad Autónoma de Nuevo León, Madero y Aguirre Pequeño s/n, 64460, Monterrey, NL, Mexico.
authors.forename: Julio
authors.initials: J
authors.lastname: Villatoro-Hernandez
authors.forename: Alma Yolanda
authors.initials: AY
authors.lastname: Arce-Mendoza
authors.forename: Adrian G
authors.initials: AG
authors.lastname: Rosas-Taraco
authors.forename: Sandra Cecilia
authors.initials: SC
authors.lastname: Esparza-González
authors.forename: Santos
authors.initials: S
authors.lastname: Guzmán-López
authors.forename: Rodrigo E
authors.initials: RE
authors.lastname: Elizondo-Omaña
authors.forename: Arturo
authors.initials: A
authors.lastname: Chávez-Reyes
authors.forename: Odila
authors.initials: O
authors.lastname: Saucedo-Cárdenas
authors.forename: Roberto Montes
authors.initials: RM
authors.lastname: de Oca Luna
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D017252:CD3 Complex / Q000378:metabolism*; D002630:Chemotactic Factors / Q000494:pharmacology*; D002633:Chemotaxis / Q000187:drug effects; D006801:Humans; D013294:Lactococcus lactis / Q000378:metabolism*; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects*; D051379:Mice; D008969:Molecular Sequence Data; D018121:Receptors, Cytokine / Q000737:chemistry / Q000378:metabolism*; D016415:Sequence Alignment
chemical_list: D017252:CD3 Complex; D002630:Chemotactic Factors; C104577:IP10-Mig receptor; D018121:Receptors, Cytokine