ABC transporters and isothiocyanates: potential for pharmacokinetic diet-drug interactions.
Isothiocyanates, a class of anti-cancer agents, are derived from cruciferous vegetables such as broccoli, cabbage and watercress, and have demonstrated chemopreventive activity in a number of cancer models and epidemiologic studies. Due to public interest in cancer prevention and alternative therapies in cancer, the consumption of herbal supplements and vegetables containing these compounds is widespread and increasing. Isothiocyanates interact with ATP-binding cassette (ABC) efflux transporters such as P-glycoprotein, MRP1, MRP2 and BCRP, and may influence the pharmacokinetics of substrates of these transporters. This review discusses the pharmacokinetic properties of isothiocyanates, their interactions with ABC transporters, and presents some data describing the potential for isothiocyanate-mediated diet-drug interactions.
Telang
Urvi
U
Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Amherst, NY 14260-1200, USA.
Ji
Yan
Y
Morris
Marilyn E
ME
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000378:metabolism; D018528:ATP-Binding Cassette Transporters / Q000378:metabolism*; D000818:Animals; D016588:Anticarcinogenic Agents / Q000378:metabolism / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000378:metabolism* / Q000494:pharmacology; D019607:Brassicaceae / Q000737:chemistry; D045744:Cell Line, Tumor; D002470:Cell Survival; D004032:Diet; D004347:Drug Interactions; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D006801:Humans; D017879:Isothiocyanates / Q000493:pharmacokinetics / Q000494:pharmacology*; D026901:Membrane Transport Proteins / Q000378:metabolism*; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D014675:Vegetables / Q000737:chemistry
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D018528:ATP-Binding Cassette Transporters; D016588:Anticarcinogenic Agents; D000972:Antineoplastic Agents, Phytogenic; D017879:Isothiocyanates; D026901:Membrane Transport Proteins; D027425:ATP-Binding Cassette, Sub-Family C Proteins; C037152:isothiocyanic acid