title: The prognostic value of CD147/EMMPRIN is associated with monocarboxylate transporter 1 co-expression in gastric cancer.
abstract: The aim of the present work was to assess the role of monocarboxylate transporters (MCTs), namely MCT1 and MCT4 as well as MCT/CD147 co-expression in gastric tissues and evaluate their clinico-pathological significance in gastric carcinoma. For that, we analysed the immunohistochemical expression of MCT1, MCT4 and CD147, in a large series of gastric samples, including non-neoplastic, tumour and metastatic tissues. A significant decrease in MCT4 plasma membrane expression was observed from non-neoplastic to gastric primary malignant tissues and to lymph-node metastasis and both MCT1 and MCT4 correlated with CD147. Importantly, both MCT4 and CD147 were more frequently expressed in Lauren's intestinal-type tumours and MCT1/CD147 co-expression was associated with advanced gastric carcinoma, Lauren's intestinal type, TNM staging and lymph-node metastasis. Our results showed that the prognostic value of CD147 was associated with MCT1 co-expression in gastric cancer cells, supporting the view that CD147 plasma membrane activity is dependent on MCT co-expression.
authors.affiliation: Life and Health Sciences Research Institute, School of Health Sciences, University of Minho, 4710-057 Braga, Portugal.
authors.forename: Céline
authors.initials: C
authors.lastname: Pinheiro
authors.forename: Adhemar
authors.initials: A
authors.lastname: Longatto-Filho
authors.forename: Kleber
authors.initials: K
authors.lastname: Simões
authors.forename: Carlos Eduardo
authors.initials: CE
authors.lastname: Jacob
authors.forename: Cláudio José Caldas
authors.initials: CJ
authors.lastname: Bresciani
authors.forename: Bruno
authors.initials: B
authors.lastname: Zilberstein
authors.forename: Ivan
authors.initials: I
authors.lastname: Cecconello
authors.forename: Venâncio Avancini Ferreira
authors.initials: VA
authors.lastname: Alves
authors.forename: Fernando
authors.initials: F
authors.lastname: Schmitt
authors.forename: Fátima
authors.initials: F
authors.lastname: Baltazar
mesh_terms: D051926:Basigin / Q000235:genetics / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D027501:Monocarboxylic Acid Transporters / Q000235:genetics / Q000378:metabolism*; D009363:Neoplasm Proteins / Q000378:metabolism*; D011379:Prognosis; D013274:Stomach Neoplasms / Q000235:genetics / Q000378:metabolism*
chemical_list: D027501:Monocarboxylic Acid Transporters; D009363:Neoplasm Proteins; D051926:Basigin