Enantioselective Michael addition of malononitrile to chalcones catalyzed by a simple quinine-Al(O(i)Pr)(3) complex: a simple method for the synthesis of a chiral 4H-pyran derivative.
Enantioselective Michael addition of malononitrile to chalcones was catalyzed by a simple quinine and Al(O(i)Pr)(3) complex and products were obtained in good ee as well as high yields, which facilitated the asymmetric synthesis of a biologically active 4H-pyran compound.
Shi
Jian
J
Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, PR China.
Wang
Min
M
He
Ling
L
Zheng
Ke
K
Liu
Xiaohua
X
Lin
Lili
L
Feng
Xiaoming
X