title: Incidence and outcomes of malignant pediatric lung neoplasms.
abstract: BACKGROUND
  We sought to define current incidence trends and outcomes for children with lung and bronchus tumors.
  
  
  METHODS
  The SEER registry was queried from 1973 to 2004 for all patients with pulmonary tumors less than 20 y of age.
  
  
  RESULTS
  Overall, 160 patients were identified. The age-adjusted incidence has remained stable at 0.049 per 100,000 persons. The median age at diagnosis was 16 y. Whites had the highest age-adjusted population incidence at 0.056 per 100,000. Most tumors arose in the lower lobe (37%), followed by the upper lobe (31.2%). The most common histology was endocrine tumor (51.6%), followed by sarcoma (11%), and mucoepidermoid tumor (9%). Overall survival was greater than 381 mo with a 15-y survival of 65%. Males had better survival (>381 versus 288 months). Endocrine and mucoepidermoid tumors had the best survival. Small cell carcinoma had the worst median survival at less than 5 mo. Squamous cell carcinoma and adenocarcinoma both had a 14-mo median survival. Median survival for nonsurgically treated patients was 14 mo with a 10-y survival rate of 32%. Surgery improved the 10-y survival to 75% (P<0.0001). Multivariate analysis demonstrated nonsurgical treatment and nonendocrine tumor histology to be independent prognostic factors of death.
  
  
  CONCLUSIONS
  The incidence of pediatric lung cancer remains stable. Several factors, including nonsurgical treatment and nonendocrine tumors confer a poor prognosis. Early diagnosis and surgical therapy provide the best chance for survival.
authors.affiliation: Division of Pediatric Surgery and Division Surgical Oncology, DeWitt Daughtry Family Department of Surgery, University of Miami Miller School of Medicine, Miami, Florida 33136, USA.
authors.forename: Holly L
authors.initials: HL
authors.lastname: Neville
authors.forename: Anthony R
authors.initials: AR
authors.lastname: Hogan
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhuge
authors.forename: Eduardo A
authors.initials: EA
authors.lastname: Perez
authors.forename: Michael C
authors.initials: MC
authors.lastname: Cheung
authors.forename: Leonidas G
authors.initials: LG
authors.lastname: Koniaris
authors.forename: William R
authors.initials: WR
authors.lastname: Thompson
authors.forename: Juan E
authors.initials: JE
authors.lastname: Sola
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D015994:Incidence; D008175:Lung Neoplasms / Q000453:epidemiology*; D008297:Male; D018426:SEER Program; D014481:United States / Q000453:epidemiology; D055815:Young Adult