title: [The expressions of PPAR-gamma, COX-2 in the lesions of patients with condyloma acuminatum and bowenoid papulosis].
abstract: OBJECTIVE
  To investigate the expression of PPAR-gamma, COX-2 in the skin lesion of condyloma acuminatum and bowenoid papulosis.
  
  
  METHODS
  The expression levels of PPAR-gamma, COX-2 were measured by immunohistochemistry in 17 cases of condyloma acuminatum, 17 cases of bowenoid papulosis, as well as 17 cases of normal foreskin lesions.
  
  
  RESULTS
  The immunohistochemical study showed that PPAR-gamma and COX-2 weakly expressed in normal foreskin, but overexepressed in the skin lesions of both condyloma acuminatum and bowenoid papulosis (P<0.01). There was straight linear correlation between the expressions of PPAR-gamma and COX-2 not only in condyloma acuminatum (r=0.505, P=0.038) but also in bowenoid papulosis (r=0.562, P=0.019).
  
  
  CONCLUSIONS
  PPAR-gamma and COX-2 may have important roles in proliferative dermatosis associated with human papilloma virus.
authors.affiliation: Department of Dermatology, West China Fouth Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Ni
authors.forename: Yi-zhi
authors.initials: YZ
authors.lastname: Zhang
authors.forename: Si-liang
authors.initials: SL
authors.lastname: Xue
mesh_terms: D000328:Adult; D000368:Aged; D001913:Bowen's Disease / Q000378:metabolism* / Q000821:virology; D003218:Condylomata Acuminata / Q000378:metabolism* / Q000821:virology; D051546:Cyclooxygenase 2 / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D047495:PPAR gamma / Q000378:metabolism*; D030361:Papillomavirus Infections / Q000378:metabolism* / Q000473:pathology; D012867:Skin / Q000378:metabolism; D055815:Young Adult
chemical_list: D047495:PPAR gamma; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human