Drug dosing in patients with impaired renal function.
Renal function can affect disposition and response to drugs in a variety of ways. This review discusses the principles underlying such responses, with particular emphasis on how changes in disposition parameters affect dosing decisions.
Brater
D C
DC
Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA. dbrater@iupui.edu
D004305:Dose-Response Relationship, Drug; D006801:Humans; D007677:Kidney Function Tests; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000378:metabolism; D010599:Pharmacokinetics; D006435:Renal Dialysis / Q000379:methods; D051437:Renal Insufficiency / Q000503:physiopathology* / Q000628:therapy
D004364:Pharmaceutical Preparations