Immunomodulatory activities of the ethanolic extract of Caesalpinia bonducella seeds.
Caesalpinia bonducella FLEMING (Caesalpiniaceae) is a plant well known for its medicinal value in Indian Ayurveda. However, to prove its efficiency for the clinical utilization, more experimental data will be beneficial.


OBJECTIVE
The present study involved the investigation of immunomodulatory activities of ethanolic extract of Caesalpinia bonducella seeds.


METHODS
Neutrophil adhesion test, haemagglutinating antibody (HA) titre, delayed-type hypersensitivity (DTH) response, phagocytic activity and cyclophosphamide-induced myelosuppression were determined by in vivo experiments.


RESULTS
The evaluation of immunomodulatory potential by oral administration of ethanolic seed extract of Caesalpinia bonducella (200-500 mg/kg) evoked a significant increase in percent neutrophil adhesion to nylon fibers as well as a dose-dependent increase in antibody titre values, and potentiated the delayed-type hypersensitivity reaction induced by sheep red blood cells. Also it prevented myelosuppression in cyclophosphamide drug treated rats and good response towards phagocytosis in carbon clearance assay.


CONCLUSIONS
The results obtained in this study indicate that Caesalpinia bonducella possesses potential immunomodulatory activity and has therapeutic potential for the prevention of autoimmune diseases.
Shukla
Shruti
S
Faculty of Life Sciences, Dr HS Gour Vishwavidyalaya, Sagar 470003, Madhya Pradesh, India. s.microb@yahoo.com
Mehta
Archana
A
John
Jinu
J
Mehta
Pradeep
P
Vyas
Suresh Prasad
SP
Shukla
Savita
S
D000818:Animals; D000906:Antibodies / Q000097:blood; D001327:Autoimmune Diseases / Q000188:drug therapy; D001773:Blood Cells / Q000187:drug effects; D029911:Caesalpinia; D002448:Cell Adhesion / Q000187:drug effects*; D003520:Cyclophosphamide; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000187:drug effects*; D005260:Female; D006968:Hypersensitivity, Delayed / Q000188:drug therapy / Q000378:metabolism*; D007155:Immunologic Factors / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D009504:Neutrophils / Q000187:drug effects*; D010587:Phagocytosis / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D012639:Seeds; D012756:Sheep
D000906:Antibodies; D007155:Immunologic Factors; D010936:Plant Extracts; D003520:Cyclophosphamide