Analysis of the mechanism for the development of allergic skin inflammation and the application for its treatment: overview of the pathophysiology of atopic dermatitis.
It has been recognized that atopic dermatitis (AD) involves allergen-driven Th2 cell polarization. In patients with AD, cytokines induce allergic inflammatory responses and subsequently enhance IgE production. Recent reports revealed that a reduced barrier function as well as altered immunity are fundamental to the development of AD because barrier disruption due to aberrant filaggrin expression is a pathological factor. However, although recent studies have improved our understanding of the pathogenesis of AD, the overall pathophysiology remains elusive. I herein discuss it based on the natural history of AD.
Terui
Tadashi
T
Department of Dermatology, Nihon University School of Medicine, Japan. terui@med.nihon-u.ac.jp
D000818:Animals; D018899:CpG Islands; D003876:Dermatitis, Atopic / Q000175:diagnosis / Q000235:genetics / Q000276:immunology*; D004195:Disease Models, Animal; D000091344:Filaggrin Proteins; D006801:Humans; D009838:Oligodeoxyribonucleotides / Q000627:therapeutic use; D012867:Skin / Q000033:anatomy & histology; D012879:Skin Physiological Phenomena
C000717249:FLG protein, human; D000091344:Filaggrin Proteins; D009838:Oligodeoxyribonucleotides