title: A nano-Ni based ultrasensitive nonenzymatic electrochemical sensor for glucose: enhancing sensitivity through a nanowire array strategy.
abstract: Highly ordered Ni nanowire arrays (NiNWAs) were synthesized for the first time using a template-directed electropolymerization strategy with a nanopore polycarbonate (PC) membrane template, and their morphological characterization were examined by scanning electron microscopy (SEM) and transmission electron microscope (TEM). A NiNWAs based electrode shows very high electrochemical activity for electrocatalytic oxidation of glucose in alkaline medium, which has been utilized as the basis of the fabrication of a nonenzymatic biosensor for electrochemical detection of glucose. The biosensor can be applied to the quantification of glucose with a linear range covering from 5.0x10(-7) to 7.0x10(-3) M, a high sensitivity of 1043 microA mM(-1) cm(-2), and a low detection limit of 1x10(-7) M. The experiment results also showed that the sensor exhibits good reproducibility and long-term stability, as well as high selectivity with no interference from other oxidable species.
authors.affiliation: State Key Laboratory of Chemical Biosensing & Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, PR China.
authors.forename: Li-Min
authors.initials: LM
authors.lastname: Lu
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Feng-Li
authors.initials: FL
authors.lastname: Qu
authors.forename: Hai-Xia
authors.initials: HX
authors.lastname: Lu
authors.forename: Xiao-Bing
authors.initials: XB
authors.lastname: Zhang
authors.forename: Zai-Sheng
authors.initials: ZS
authors.lastname: Wu
authors.forename: Shuang-Yan
authors.initials: SY
authors.lastname: Huan
authors.forename: Qiu-An
authors.initials: QA
authors.lastname: Wang
authors.forename: Guo-Li
authors.initials: GL
authors.lastname: Shen
authors.forename: Ru-Qin
authors.initials: RQ
authors.lastname: Yu
mesh_terms: D015374:Biosensing Techniques / Q000379:methods*; D004563:Electrochemistry / Q000379:methods*; D004566:Electrodes; D005947:Glucose / Q000032:analysis*; D053770:Nanowires / Q000737:chemistry* / Q000648:ultrastructure; D009532:Nickel / Q000737:chemistry*; D010084:Oxidation-Reduction; D012680:Sensitivity and Specificity
chemical_list: D009532:Nickel; D005947:Glucose