Limb development: the rise and fall of retinoic acid.
Retinoic acid was thought to play a key instructive role during limb bud initiation and subsequent patterning. New results argue instead that its role is permissive: retinoic acid is essential only to antagonize early axial Fgf signals that otherwise inhibit the limb field.
Lewandoski
Mark
M
Cancer and Developmental Biology Laboratory, National Cancer Institute, NCI-Frederick, Frederick, MD 21702, USA. mlewandoski@mail.ncifcrf.gov
Mackem
Susan
S
D000818:Animals; D019521:Body Patterning / Q000502:physiology*; D005121:Extremities / Q000196:embryology*; D005346:Fibroblast Growth Factors / Q000037:antagonists & inhibitors / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D008954:Models, Biological; D015398:Signal Transduction / Q000502:physiology*; D014212:Tretinoin / Q000378:metabolism*
D014212:Tretinoin; D005346:Fibroblast Growth Factors