title: Characteristics and antioxidant activity of catechin-loaded calcium pectinate gel beads prepared by internal gelation.
abstract: Catechin-loaded calcium pectinate gel beads prepared by internal gelation were characterized for their catechin entrapment efficiency and release behavior. The entrapment efficiency was higher when the beads were prepared with a lower catechin-to-pectin ratio, shorter gelling time, higher pectin concentration, and lower acetic acid concentration. The entrapment efficiency was much higher under all tested conditions, when the beads were prepared by internal gelation instead of external gelation. The catechin release was slower for the beads prepared with lower catechin-to-pectin ratio, longer gelling time, and higher concentrations of pectin and acetic acid in both simulated gastric and intestinal fluids. Antioxidant power of catechin was effectively maintained in alkaline simulated intestinal fluid when catechin was entrapped within the beads, compared to cases where it was not entrapped, indicating that the beads can protect catechin molecules from the alkaline environment and release them in a sustained fashion.
authors.affiliation: Department of Food and Nutrition, Hanyang University, 17 Haengdang-dong, Seongdong-gu, Seoul 133-791, Republic of Korea.
authors.forename: Ji-Soo
authors.initials: JS
authors.lastname: Lee
authors.forename: Eek-Joo
authors.initials: EJ
authors.lastname: Kim
authors.forename: Donghwa
authors.initials: D
authors.lastname: Chung
authors.forename: Hyeon Gyu
authors.initials: HG
authors.lastname: Lee
mesh_terms: D000975:Antioxidants / Q000494:pharmacology*; D002392:Catechin / Q000494:pharmacology*; D016503:Drug Delivery Systems / Q000379:methods*; D005782:Gels; D008863:Microspheres; D010368:Pectins / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D000975:Antioxidants; D005782:Gels; D010368:Pectins; D002392:Catechin