[Expression of annexin V in decidua tissues of preeclampsia patients].
OBJECTIVE
To investigate the expression of annexin V in the decidua tissues of preeclampsia patients and explore its clinical significance.


METHODS
Real-time PCR, Western blotting and immunohistochemistry were employed to detect the mRNA and protein expressions of annexin V in the deciduas from 35 normal pregnant women at full term, 38 early onset severe preeclampsia patients and 33 late onset severe preeclampsia patients.


RESULTS
Annexin V was found on the cell membrane and in the cytoplasm of the decidual cells and stroma. Both the mRNA and protein of annexin V expressions in the decidua tissues were significantly different between normal pregnancy group and early or late onset severe preeclampsia group (P<0.05), being the highest in normal pregnancy group and the lowest in early onset severe preeclampsia group.


CONCLUSIONS
The low expression of annexin V in the deciduas might participate in the hypercoagulability state in preeclampsia patients.
Feng
Ya-Ling
YL
Department of Obstetrics and Gynecology, Third Affiliated Hospital of Xiangya Medical College, Central South University, Changsha 410013, China. fengyl523@yahoo.com.cn
Zhou
Chang-Ju
CJ
Xue
Min
M
D000328:Adult; D017304:Annexin A5 / Q000378:metabolism*; D016022:Case-Control Studies; D003656:Decidua / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D011225:Pre-Eclampsia / Q000378:metabolism* / Q000473:pathology; D011247:Pregnancy; D012333:RNA, Messenger / Q000235:genetics
D017304:Annexin A5; D012333:RNA, Messenger