title: How well do vital signs identify children with serious infections in paediatric emergency care?
abstract: OBJECTIVE
  To determine whether vital signs identify children with serious infections, and to compare their diagnostic value with that of the Manchester triage score (MTS) and National Institute for Health and Clinical Excellence (NICE) traffic light system of clinical risk factors.
  
  
  METHODS
  Prospective cohort of children presenting with suspected acute infection. We recorded vital signs, level of consciousness, activity level, respiratory distress, hydration and MTS category.
  
  
  METHODS
  Paediatric assessment unit at a teaching hospital in England.
  
  
  METHODS
  700 children (median age 3 years), of whom 357 (51.0%) were referred from primary care, 198 (28.3%) self-referrals and 116 (16.6%) emergency ambulance transfers. Just over half (383 or 54.7%) were admitted.
  
  
  METHODS
  Severity of infection categorised as serious, intermediate, minor or not infection.
  
  
  RESULTS
  Children with serious or intermediate infections (n = 313) were significantly more likely than those with minor or no infection (n = 387) to have a temperature >or=39 degrees C, tachycardia, saturations <or=94% or capillary refill time (CRT) >2 seconds. Having one or more of temperature >or=39 degrees C, saturations <or=94%, tachycardia and tachypnoea was 80% (95% CI 75% to 85%) sensitive and 39% (95% CI 34% to 44%) specific for serious or intermediate infection. This was comparable to the MTS score (84% sensitive, 38% specific), and the NICE traffic light system (85% sensitive, 29% specific).
  
  
  CONCLUSIONS
  A combination of vital signs can be used to differentiate children with serious infections from those with less serious infections in a paediatric assessment unit and has comparable sensitivity to more complicated triage systems. The diagnostic value of combined vital signs and the NICE traffic light system remains to be determined in populations where the prevalence of severe illness is much lower.
authors.affiliation: Department of Primary Health Care, Oxford University, Oxford, UK. matthew.thompson@dphpc.ox.ac.uk
authors.forename: M
authors.initials: M
authors.lastname: Thompson
authors.forename: N
authors.initials: N
authors.lastname: Coad
authors.forename: A
authors.initials: A
authors.lastname: Harnden
authors.forename: R
authors.initials: R
authors.lastname: Mayon-White
authors.forename: R
authors.initials: R
authors.lastname: Perera
authors.forename: D
authors.initials: D
authors.lastname: Mant
mesh_terms: D000208:Acute Disease; D002675:Child, Preschool; D004632:Emergency Medical Services / Q000379:methods; D004636:Emergency Service, Hospital; D004739:England; D005260:Female; D006801:Humans; D007239:Infections / Q000175:diagnosis* / Q000503:physiopathology; D008297:Male; D010372:Pediatrics; D017410:Practice Guidelines as Topic; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D014218:Triage; D055986:Vital Signs