title: Isoprenylated chromone derivatives from the plant endophytic fungus Pestalotiopsis fici.
abstract: Pestaloficiols F-L (1-7), new isoprenylated chromone derivatives including one heterodimer (7), have been isolated from a scale-up fermentation extract of the plant endophytic fungus Pestalotiopsis fici. The structures of these compounds were elucidated primarily by NMR and MS methods. The absolute configurations of 1 and 4 were assigned using the modified Mosher method. Compounds 1-3, 5, and 6 displayed inhibitory effects on HIV-1 replication in C8166 cells, whereas 4-7 showed cytotoxic activity against the human tumor cell lines HeLa and MCF7.
authors.affiliation: Key Laboratory of Systematic Mycology & Lichenology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, People's Republic of China.
authors.forename: Ling
authors.initials: L
authors.lastname: Liu
authors.forename: Shuchun
authors.initials: S
authors.lastname: Liu
authors.forename: Shubin
authors.initials: S
authors.lastname: Niu
authors.forename: Liangdong
authors.initials: L
authors.lastname: Guo
authors.forename: Xulin
authors.initials: X
authors.lastname: Chen
authors.forename: Yongsheng
authors.initials: Y
authors.lastname: Che
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D028241:Camellia sinensis / Q000382:microbiology; D002867:Chromones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D015497:HIV-1 / Q000187:drug effects; D006367:HeLa Cells; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013098:Xylariales / Q000737:chemistry*
chemical_list: D019380:Anti-HIV Agents; D000970:Antineoplastic Agents; D002867:Chromones