Rapid development of metastatic Xp11 translocation renal cell carcinoma in a girl treated for neuroblastoma.
We report the case of a 5-year-old girl with metastatic renal cell carcinoma (RCC) diagnosed 19 months after treatment for neuroblastoma. Immunostaining of the secondary tumor was consistent with Xp11 translocation morphology. This is the second report of this translocation RCC presenting after neuroblastoma and the most rapid onset of RCC reported thus far. The literature regarding secondary RCC after neuroblastoma is reviewed and our case is placed within this historical context. As our understanding of the genetic changes in pediatric tumors advances, the reporting of these rare cases with specific emphasis on genetic testing provides a resource for clinicians and researchers.
Hedgepeth
Ryan C
RC
Department of Urology, University of Michigan, Ann Arbor, MI 48109, USA. rhedge@umich.edu
Zhou
Ming
M
Ross
Jonathan
J
D002292:Carcinoma, Renal Cell / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D002675:Child, Preschool; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics; D041321:Chromosomes, Human, X / Q000235:genetics; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D009362:Neoplasm Metastasis; D016609:Neoplasms, Second Primary / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D009447:Neuroblastoma / Q000473:pathology* / Q000628:therapy*; D014178:Translocation, Genetic