title: Fulminant amoebic colitis during chemotherapy for advanced gastric cancer.
abstract: A 52-year-old man had bloody stools during chemotherapy for gastric cancer. A colonoscopy revealed necrotizing ulcer-like changes. A biopsy confirmed the presence of amoebic trophozoites. Subsequently, peritonitis with intestinal perforation developed, and emergency peritoneal lavage and colostomy were performed. After surgery, endotoxin adsorption therapy was performed and metronidazole was given. Symptoms of peritonitis and colonitis resolved. However, the patient's general condition worsened with the progression of gastric cancer. The patient died 50 d after surgery. Fulminant amoebic colitis is very rarely associated with chemotherapy. Amoebic colitis should be considered in the differential diagnosis of patients who have bloody stools during chemotherapy.
authors.affiliation: Department of Gastroenterology, Kitasato University School of Medicine, 2-1-1 Asamizodai, Sagamihara-City, Kanagawa 228-8520, Japan. hanaoka-no@mc.pref.osaka.jp
authors.forename: Noboru
authors.initials: N
authors.lastname: Hanaoka
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Higuchi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Tanabe
authors.forename: Tohru
authors.initials: T
authors.lastname: Sasaki
authors.forename: Kenji
authors.initials: K
authors.lastname: Ishido
authors.forename: Takako
authors.initials: T
authors.lastname: Ae
authors.forename: Wasaburo
authors.initials: W
authors.lastname: Koizumi
authors.forename: Katsunori
authors.initials: K
authors.lastname: Saigenji
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use; D000981:Antiprotozoal Agents / Q000627:therapeutic use; D004404:Dysentery, Amebic / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D017809:Fatal Outcome; D006801:Humans; D007416:Intestinal Perforation / Q000209:etiology*; D008297:Male; D008795:Metronidazole / Q000627:therapeutic use; D008875:Middle Aged; D010538:Peritonitis / Q000188:drug therapy / Q000209:etiology*; D013274:Stomach Neoplasms / Q000150:complications* / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents; D000981:Antiprotozoal Agents; D008795:Metronidazole