[Antioxidative activity of thiophane [bis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propyl)sulfide].
The antioxidant activity, mutagenicity, and genotoxicity of bis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propyl)sulfide (thiophane) were studied using bacterial tests. The results of both an Ames test and SOS chromotest, as well as those studying the survival of E. coli cells deficient in enzymes responsible for the repair of DNA oxidative damage, testify to the fact that thiophane is not mutagenic and genotoxic, and it protects Salmonella typhimurium cells better than the well-known antioxidant trolox.
Ovchinnikova
L P
LP
Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, pr. Akademika Lavrent'eva 10, Novosibirsk, 630090 Russia.
Rotskaia
U N
UN
Vasiunina
E A
EA
Sinitsina
O I
OI
Kandalintseva
N V
NV
Prosenko
A E
AE
Nevinskiĭ
G A
GA
D000975:Antioxidants / Q000494:pharmacology* / Q000633:toxicity; D004249:DNA Damage; D004926:Escherichia coli / Q000187:drug effects; D009152:Mutagenicity Tests; D018384:Oxidative Stress / Q000187:drug effects; D010636:Phenols / Q000494:pharmacology* / Q000633:toxicity; D012486:Salmonella typhimurium / Q000187:drug effects; D013440:Sulfides / Q000494:pharmacology* / Q000633:toxicity
D000975:Antioxidants; D010636:Phenols; D013440:Sulfides; C542629:bis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propyl)sulfide