title: Pediatric high-grade gliomas and diffuse intrinsic pontine gliomas.
abstract: Pediatric high-grade gliomas represent approximately 10% of all pediatric brain tumors. Similar to adult high-grade gliomas, they behave very aggressively, and these children have a very poor prognosis despite a variety of therapies that include chemotherapy and radiotherapy. In this review, we present an overview of both pediatric high-grade gliomas and diffuse intrinsic pontine gliomas with a focus on their epidemiology, etiology, presentation, prognostic factors, biology, treatment modalities, outcomes, and future research directions.
authors.affiliation: Department of Hematology/Oncology/Stem Cell Transplantation, Children's Memorial Hospital, Chicago, IL 60614, USA. jfangusaro@childrensmemorial.org
authors.forename: Jason
authors.initials: J
authors.lastname: Fangusaro
mesh_terms: D001932:Brain Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology / Q000628:therapy; D020295:Brain Stem Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology / Q000628:therapy; D002648:Child; D005910:Glioma / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology / Q000628:therapy; D006801:Humans; D008959:Models, Neurological; D009367:Neoplasm Staging