title: Salivary gland myoepithelioma with focal capsular invasion.
abstract: Salivary gland tumors that display myoepithelial differentiation exclusively or predominantly are relatively uncommon, and the assessment of malignancy in a myoepithelial tumor can be difficult. We report a case of parotid gland myoepithelioma composed predominantly of spindle cells with focal capsular invasion. The patient was a 65-year-old woman who presented with a painless mass in the right preauricular region. Histologically, the tumor had a solid and multinodular growth pattern and was predominantly made up of spindle cells with a minor component of epithelioid cells with moderate cellular atypia. Focal regions of tumor cells infiltrated the capsule with tongue-like processes, but tumor infiltration into the adjacent parotid tissue was absent. The tumor cells showed strong cytoplasmic immunoexpression of vimentin, pankeratin, S-100 protein, and smooth-muscle actin. Immunostains with glial fibrillary acidic protein, melanoma marker, epithelial membrane antigen, and carcinoembryonic antigen were negative. Expression of p53 was observed focally in the nuclei of the tumor cells. A final diagnosis of salivary gland myoepithelioma with focal capsular invasion was made, and the case was regarded as a myoepithelial tumor of uncertain malignant potential. In this report, we discuss the histologic criteria required to diagnose malignancy in salivary gland myoepithelial tumors.
authors.affiliation: Department of Pathology, Zonguldak Karaelmas Universitesi Tip Fakultesi, Patoloji Anabilim Dali, 67600 Kozlu, Zonguldak, Turkey. dogagun2@yahoo.com
authors.forename: Banu Dogan
authors.initials: BD
authors.lastname: Gun
authors.forename: Sukru Oguz
authors.initials: SO
authors.lastname: Ozdamar
authors.forename: Burak
authors.initials: B
authors.lastname: Bahadir
authors.forename: Lokman
authors.initials: L
authors.lastname: Uzun
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D009208:Myoepithelioma / Q000473:pathology* / Q000601:surgery; D010306:Parotid Gland / Q000473:pathology* / Q000601:surgery; D010307:Parotid Neoplasms / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor