title: Association of monocyte chemoattractant protein 1 gene polymorphism with susceptibility to nonfamilial idiopathic dilated cardiomyopathy.
abstract: BACKGROUND
  The cytotoxic action of leukocytes is known to be a probable cause of the cardiac myocyte damage seen in idiopathic dilated cardiomyopathy (IDC). Monocyte chemoattractant protein 1 (MCP-1) contributes to enhanced leukocyte recruitment and activation resulting in chronic damage of cardiomyocytes. MCP-1 has been reported to be dynamically regulated in IDC and may contribute to the deterioration of left ventricular function. In addition, a polymorphism at -2518 (G/A) in the MCP-1 gene affects the level of MCP-1 expression in response to an inflammatory stimulus.
  
  
  RESULTS
  We genotyped the polymorphism at -2518 G/A in the MCP-1 gene in 73 Japanese patients with nonfamilial IDC and 349 healthy controls. The distribution of the MCP-1 genotypes in the IDC patients differed significantly from the controls (p=0.016). In a dominant G allele model, there was a significant difference in the distribution of genotypes between the two groups (p<0.01). The odds ratio for nonfamilial IDC associated with the GG vs. non-GG genotype was 10.4 (95% CI=1.7-64.5) after adjustment for the confounding factors.
  
  
  CONCLUSIONS
  These findings suggest that the G allele at -2518 in the MCP-1 gene may be a novel genetic marker of susceptibility to nonfamilial IDC.
authors.affiliation: Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime 791-0295, Japan. aogimoto@m.ehime-u.ac.jp
authors.forename: Akiyoshi
authors.initials: A
authors.lastname: Ogimoto
authors.forename: Hideki
authors.initials: H
authors.lastname: Okayama
authors.forename: Takayuki
authors.initials: T
authors.lastname: Nagai
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Ohtsuka
authors.forename: Jun
authors.initials: J
authors.lastname: Suzuki
authors.forename: Katsuji
authors.initials: K
authors.lastname: Inoue
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Nishimura
authors.forename: Yuji
authors.initials: Y
authors.lastname: Shigematsu
authors.forename: Yasuharu
authors.initials: Y
authors.lastname: Tabara
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Kohara
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Miki
authors.forename: Jitsuo
authors.initials: J
authors.lastname: Higaki
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002311:Cardiomyopathy, Dilated / Q000235:genetics*; D018932:Chemokine CCL2 / Q000235:genetics*; D002648:Child; D005260:Female; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D055815:Young Adult
chemical_list: D018932:Chemokine CCL2; D005819:Genetic Markers