Evaluation of the agreement between clinical and laboratorial exams in the diagnosis of leprosy.
This study examined the correlation between the clinical and laboratory diagnosis of leprosy, using biopsy results from laboratories 'A' and 'B' and the ML Flow test. Clinical and histopathological diagnoses presented 67.6% agreement. The laboratories showed 73.7% agreement in the bacterial index and laboratory 'B' detected 25.4% more positives. The highest agreement was in the LL form and lowest, in the I form. The highest diagnostic discrepancy was for the BB form. Clinical diagnosis agreement was 41.3% for laboratory 'A' and 54% for 'B'. The ML Flow test reclassified 10.7% of the patients. The spectrum of leprosy classification is important for a clearer understanding of the disease and its proper treatment, but is not used in health services, which use the simplified WHO criteria. This could be complemented by ML Flow testing. Such simplification is unacceptable for Leprosy Reference Centers regarding patient attendance, teaching and research, for which the standardization of the Ridley-Jopling classification is recommended.
Teixeira
André Costa
AC
National Reference Center for Sanitary Dermatology and Leprosy, Clinical Hospital, Faculty of Medicine, Federal University of Uberlândia, MG, Brazil.
Cruvinel
Danilo Lemos
DL
Roma
Fábio Rodrigues de
FR
Luppino
Leandro Ferreira
LF
Resende
Luís Henrique Pereira
LH
Sousa
Theo de
Td
Bührer-Sékula
Samira
S
Goulart
Isabela Maria Bernardes
IM
D000907:Antibodies, Bacterial / Q000097:blood*; D000942:Antigens, Bacterial; D001706:Biopsy; D006017:Glycolipids; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D007918:Leprosy / Q000145:classification / Q000175:diagnosis* / Q000473:pathology; D009166:Mycobacterium leprae / Q000276:immunology*; D012867:Skin / Q000382:microbiology / Q000473:pathology*
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D006017:Glycolipids; D007075:Immunoglobulin M; C045169:phenolic glycolipid I, Mycobacterium leprae