title: Drug-to-drug interaction between dapsone and minocycline: an unusual cause of relapse of toxoplasmic encephalitis in an HIV-infected patient.
abstract: HIV-infected patients with opportunistic infections receive therapeutic regimens that often contain numerous drugs and are then exposed to potential drug-to-drug interactions. We report here an unusual case of relapse of toxoplasmic encephalitis in an HIV-infected patient, possibly due to a drug-to-drug interaction between dapsone and minocycline.
authors.affiliation: Department of Infectious and Tropical Diseases, Paris 7 Diderot University, Paris, France. sebastien_gallien@yahoo.fr
authors.forename: Sébastien
authors.initials: S
authors.lastname: Gallien
authors.forename: Naike
authors.initials: N
authors.lastname: Bigé
authors.forename: Marie-Dominique
authors.initials: MD
authors.lastname: Kitzis
authors.forename: Pascale
authors.initials: P
authors.lastname: Longuet
authors.forename: Anne
authors.initials: A
authors.lastname: Gervais
authors.forename: Catherine
authors.initials: C
authors.lastname: Leport
mesh_terms: D000328:Adult; D003622:Dapsone / Q000008:administration & dosage* / Q000009:adverse effects; D004347:Drug Interactions; D004660:Encephalitis / Q000188:drug therapy* / Q000469:parasitology / Q000821:virology; D015658:HIV Infections / Q000469:parasitology*; D015497:HIV-1 / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008911:Minocycline / Q000008:administration & dosage* / Q000009:adverse effects; D012008:Recurrence; D014122:Toxoplasma / Q000302:isolation & purification; D016781:Toxoplasmosis, Cerebral / Q000188:drug therapy* / Q000469:parasitology / Q000821:virology
chemical_list: D003622:Dapsone; D008911:Minocycline