title: Development of hydroxyapatite/calcium silicate composites addressed to the design of load-bearing bone scaffolds.
abstract: This work deals with the preparation of bioactive ceramic composites to be employed for the development of load-bearing bone substitutes, made of hydroxyapatite (Ca(10)(PO(4))(6)(OH)(2), HA) and bioactive dicalcium silicate (Ca(2)SiO(4), C(2)S) as a reinforcing phase. The composite materials were prepared by Fast Hot-Pressing (FHP), which allowed the rapid sintering of monolithic ceramics at temperatures up to 1500 degrees C, well above the commonly adopted temperatures for the consolidation of hydroxyapatite (1200-1300 degrees C). The purpose was to achieve the grain coalescence of both HA and the strengthening phase, so that to obtain a homogeneous ceramic material characterized by controlled phase composition and improved mechanical strength; the dwell time was reduced as much as possible to prevent HA decomposition and excessive grain growth. The most remarkable result, in terms of phase composition, was the absence of any secondary phases in the final ceramics other than HA and C(2)S, even after sintering at 1500 degrees C. The flexure strength of the composite materials was found to be much higher than that of HA alone. Further mechanical characterization was also carried out on HA and composites, sintered in different conditions, to evaluate the elastic properties and fracture toughness, and properties close to those of mineral bone were found. These preliminary results confirmed that composites of HA and Ca(2)SiO(4) are promising for the development of bioactive load-bearing ceramic bone substitutes with controlled phase composition.
authors.affiliation: Institute of Science and Technology for Ceramics, ISTEC-CNR, Via Granarolo 64, 48018 Faenza, RA, Italy. sprio@istec.cnr.it
authors.forename: Simone
authors.initials: S
authors.lastname: Sprio
authors.forename: Anna
authors.initials: A
authors.lastname: Tampieri
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Celotti
authors.forename: Elena
authors.initials: E
authors.lastname: Landi
mesh_terms: D001696:Biomechanical Phenomena; D001842:Bone and Bones / Q000166:cytology / Q000502:physiology*; D017610:Calcium Compounds / Q000737:chemistry*; D055598:Chemical Phenomena; D017886:Durapatite / Q000737:chemistry*; D017640:Silicates / Q000737:chemistry*; D013696:Temperature; D054457:Tissue Scaffolds / Q000737:chemistry*; D016474:Weight-Bearing; D014961:X-Ray Diffraction
chemical_list: D017610:Calcium Compounds; D017640:Silicates; D017886:Durapatite; C031293:calcium silicate