[Analysis of pancreatic leaking-related risk factors after pancreaticoduodenectomy].
OBJECTIVE
To analysis the risk factors of pancreatic fistula after pancreaticoduodenectomy (PD).


METHODS
A retrospective clinical study had been done in 97 patients who underwent PD between June 2001 and June 2006. The two groups were first compared by the univariate analysis;logistic regression was then used to determine the effect of multiple factors on pancreatic fistula. A P-value of less than 0.05 was considered to be statistically significant.


RESULTS
Of the 97 patients, 13 patients were identified as having pancreatic fistula. Factors significantly increasing the risk of pancreatic fistula by univariate analysis included preoperative serum total bilirubin (P = 0.038), operative time (P = 0.003) and whether or not Braun anastomosis (P = 0.034), and prophylactic use of somatostatin (P = 0.003) after operation. A multivariate logistic regression analysis revealed the factors most highly associated with pancreatic fistula to be preoperative serum total bilirubin (OR = 11.687, P = 0.021) and postoperative prophylactic use of somatostatin (OR = 0.056, P = 0.020).


CONCLUSIONS
Preoperative serum total bilirubin more than 170 mmol/L was a risk factor of pancreatic fistula after PD, and postoperative prophylactic use of somatostatin was a protect factor of pancreatic fistula after PD.
Li
Xin
X
Department of General Surgery, the First Affiliated Hospital of China Medical University, Shenyang 110001, China.
Dong
Ming
M
Zhou
Jian-ping
JP
Li
Yu-ji
YJ
Kong
Fan-min
FM
Tian
Yu-lin
YL
D000328:Adult; D000368:Aged; D001663:Bilirubin / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010185:Pancreatic Fistula / Q000209:etiology*; D016577:Pancreaticoduodenectomy / Q000009:adverse effects*; D011183:Postoperative Complications / Q000209:etiology; D012189:Retrospective Studies; D012307:Risk Factors; D013004:Somatostatin / Q000627:therapeutic use; D055815:Young Adult
D013004:Somatostatin; D001663:Bilirubin