title: Treatment of osteochondritis dissecans of the femoral condyle with autologous bone grafts and matrix-supported autologous chondrocytes.
abstract: The objective of this study was to determine the clinical outcome of combined bone grafting and matrix-supported autologous chondrocyte transplantation in patients with osteochondritis dissecans of the knee. Between January 2003 and March 2005, 21 patients (mean age 29.33 years) with symptomatic osteochondritis dissecans (OCD) of the medial or lateral condyle (grade III or IV) of the knee underwent reconstruction of the joint surface by autologous bone grafts and matrix-supported autologous chondrocyte transplantation. Patients were followed up at three, six, 12 and 36 months to determine outcomes by clinical evaluation based on Lysholm score, IKDC and ICRS score. Clinical results showed a significant improvement of Lysholm-score and IKDC score. With respect to clinical assessment, 18 of 21 patients showed good or excellent results 36 months postoperatively. Our study suggests that treatment of OCD with autologous bone grafts and matrix-supported autologous chondrocytes is a possible alternative to osteochondral cylinder transfer or conventional ACT.
authors.affiliation: Department of Orthopaedics, University of Hamburg, Hamburg, Germany. steinhagen@uke.uni-hamburg.de
authors.forename: Joern
authors.initials: J
authors.lastname: Steinhagen
authors.forename: Juergen
authors.initials: J
authors.lastname: Bruns
authors.forename: Georg
authors.initials: G
authors.lastname: Deuretzbacher
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Ruether
authors.forename: Martin
authors.initials: M
authors.lastname: Fuerst
authors.forename: Oliver
authors.initials: O
authors.lastname: Niggemeyer
mesh_terms: D000293:Adolescent; D000328:Adult; D016025:Bone Transplantation / Q000379:methods*; D019902:Chondrocytes / Q000637:transplantation*; D003094:Collagen; D005260:Female; D005269:Femur / Q000601:surgery*; D005500:Follow-Up Studies; D006801:Humans; D007719:Knee Joint / Q000601:surgery*; D008297:Male; D010008:Osteochondritis Dissecans / Q000601:surgery*; D020127:Recovery of Function; D014014:Tissue Adhesives / Q000627:therapeutic use; D020858:Tissue and Organ Harvesting / Q000379:methods*; D014182:Transplantation, Autologous / Q000379:methods; D055815:Young Adult
chemical_list: D014014:Tissue Adhesives; D003094:Collagen