title: Consumption of statins in Croatia in the 2002 - 2006 period--a retrospective study.
abstract: OBJECTIVE
  The objective of this research is to quantify the trends in the consumption of statins in the Republic of Croatia on the national level in the 5-year period between 2002 and 2006.
  
  
  METHODS
  Data on the consumption of different statins have been obtained from the database of the Croatian Institute of Health Insurance. Statistical Annals have provided data on the population in the Republic of Croatia for the period observed. Consumption of statins expressed in Defined daily doses (DDD) per 1,000 inhabitants per day (DID) was computed and statistically processed.
  
  
  RESULTS
  Of the total number of insured persons statins were used in the treatment of 2.57% patients in 2002 and grew to 6.48% in 2006. The total consumption of statins was increased from 12.39 DID in 2002 to 44.77 DID in 2006. In the period observed, simvastatin had the greatest individual share in the consumption of statins. Thus in 2002 it accounted for 73.12% of the total consumption of statins, while in 2006 it was 48.87%. The share of other statins in the total consumption did not change substantially, except for atorvastatin, whose share increased from 15.3% in 2002 to 42.38% in 2006. Mostly women (57%) and patients above 55 years of age were treated with statins.
  
  
  CONCLUSIONS
  In the 2002 - 2006 period the total consumption of statins increased by 261%, while the number of patients treated with statins increased by 252%. Simvastatin had the greatest share in the total consumption, while atorvastatin consumption recorded the greatest individual increase.
authors.affiliation: Faculty of Pharmacy and Biochemistry, University of Zagreb, Croatia. dijana.grgurevic@gmail.com
authors.forename: D
authors.initials: D
authors.lastname: Grgurevic
authors.forename: J
authors.initials: J
authors.lastname: Grgurevic
authors.forename: T
authors.initials: T
authors.lastname: Strizrep
authors.forename: V
authors.initials: V
authors.lastname: Bacic Vrca
authors.forename: L
authors.initials: L
authors.lastname: Grgurevic
mesh_terms: D000367:Age Factors; D017523:Croatia; D016208:Databases, Factual; D004363:Drug Utilization / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D006949:Hyperlipidemias / Q000188:drug therapy*; D007348:Insurance, Health; D008297:Male; D012189:Retrospective Studies; D012737:Sex Factors
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors