Decrease in the kainate-induced wet dog shake behavior in genetically epilepsy-prone rats: possible involvement of an impaired synaptic transmission to the 5-HT(2A) receptor.
Genetically epilepsy-prone rats (GEPR-9s) were derived from Sprague-Dawley rats (SD). The number of kainate-induced wet dog shake behavior (WDS) responses was found to decrease significantly in GEPR-9s compared to SD. WDS responses were potentiated by 5-hydroxytryptophan or 2,5-dimethoxy-4-iodoamphetamine and antagonized by ritanserin. The antagonizing effect of ritanserin on WDS latency was more evident in GEPR-9s than in SD, and hippocampal expression of activity-regulated cytoskeleton-associated protein paralleled the severity of WDS. The results suggest that downstream serotonergic synaptic activation is less pronounced in GEPR-9s than in SD and that the serotonergic agent may directly activate postsynaptic 5-HT2A receptors in both strains.
Shin
Eun-Joo
EJ
Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chunchon, Korea.
Jeong
Ji Hoon
JH
Chung
Yoon Hee
YH
Kim
Tae-Woo
TW
Shin
Chan Young
CY
Kim
Won-Ki
WK
Ko
Kwang-Ho
KH
Kim
Hyoung-Chun
HC
D000818:Animals; D001522:Behavior, Animal; D003598:Cytoskeletal Proteins / Q000378:metabolism; D004195:Disease Models, Animal; D004827:Epilepsy / Q000235:genetics*; D007608:Kainic Acid / Q000494:pharmacology*; D009419:Nerve Tissue Proteins / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D044402:Receptor, Serotonin, 5-HT2A / Q000502:physiology*; D016713:Ritanserin / Q000494:pharmacology; D009435:Synaptic Transmission / Q000502:physiology*
D003598:Cytoskeletal Proteins; D009419:Nerve Tissue Proteins; D044402:Receptor, Serotonin, 5-HT2A; C092069:activity regulated cytoskeletal-associated protein; D016713:Ritanserin; D007608:Kainic Acid