title: Mapping of the full length and the truncated interleukin-18 receptor alpha in the mouse brain.
abstract: The cytokine IL-18 acts on the CNS both in physiological and pathological conditions. Its action occurs through the heterodimeric receptor IL-18Ralpha\beta. To better understand IL-18 central effects, we investigated in the mouse brain the distribution of two IL-18Ralpha transcripts, a full length and an isoform lacking the intracellular domain hypothesized to be a decoy receptor. Both isoforms were expressed in neurons throughout the brain primarily with overlapping distribution but also with some unique pattern. These data suggest that IL-18 may modulate neuronal functions and that its action may be regulated through expression of a decoy receptor.
authors.affiliation: Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy. salboni@unimore.it
authors.forename: Silvia
authors.initials: S
authors.lastname: Alboni
authors.forename: Davide
authors.initials: D
authors.lastname: Cervia
authors.forename: Brendon
authors.initials: B
authors.lastname: Ross
authors.forename: Claudia
authors.initials: C
authors.lastname: Montanari
authors.forename: Alejandro Sanchez
authors.initials: AS
authors.lastname: Gonzalez
authors.forename: Manuel
authors.initials: M
authors.lastname: Sanchez-Alavez
authors.forename: Maria Cecilia Garibaldi
authors.initials: MC
authors.lastname: Marcondes
authors.forename: David
authors.initials: D
authors.lastname: De Vries
authors.forename: Shuei
authors.initials: S
authors.lastname: Sugama
authors.forename: Nicoletta
authors.initials: N
authors.lastname: Brunello
authors.forename: Joan
authors.initials: J
authors.lastname: Blom
authors.forename: Fabio
authors.initials: F
authors.lastname: Tascedda
authors.forename: Bruno
authors.initials: B
authors.lastname: Conti
mesh_terms: D017398:Alternative Splicing; D000818:Animals; D001921:Brain / Q000276:immunology / Q000378:metabolism*; D002531:Cerebellum / Q000378:metabolism; D002540:Cerebral Cortex / Q000378:metabolism; D005091:Exons; D006624:Hippocampus / Q000378:metabolism; D007031:Hypothalamus / Q000378:metabolism; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D020382:Interleukin-18 / Q000276:immunology / Q000378:metabolism*; D053727:Interleukin-18 Receptor alpha Subunit / Q000276:immunology / Q000378:metabolism*; D053728:Interleukin-18 Receptor beta Subunit / Q000378:metabolism; D007438:Introns; D051379:Mice; D008810:Mice, Inbred C57BL; D020033:Protein Isoforms; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014158:Transcription, Genetic
chemical_list: D020382:Interleukin-18; D053727:Interleukin-18 Receptor alpha Subunit; D053728:Interleukin-18 Receptor beta Subunit; D020033:Protein Isoforms