title: Anticarcinogenic effects of Solanum lycopersicum fruit extract on Swiss albino and C57 Bl mice.
abstract: In the present studies, the effect of Solanum lycopersicum extract on DMBA induced skin papillomas and B6 F10 melanomas was studied. Topical single application of DMBA at the dose of 4 mg/kg b.wt. followed by 1 % croton oil for 16 weeks produced a 100% incidence of skin papillomas which started appearing from the 6th week onwards. The mice which additionally received S. lycopersicum extract at 0.6 g/kg 2 day/week for 16 weeks showed a significant decrease in the number and incidence of tumors (p<0.05), with a delay in their appearance to week 10. Histopathological examination showed well and poorly differentiated squamous cell carcinomas in the group which received DMBA + Croton oil treatment whereas hyperkeratosis and hyperplasia were more prevalent in DMBA + Croton oil + Lycopersicum extract treated animals. In a second experiment the effect of cyclophosphamide alone and in combination with S. lycopersicum extract was studied in B16F10 melanoma tumour bearing mice. The inhibition rate was 25.9% in the cyclophosphamide treated group but this increased to 37.7% with S. lycopersicum. The life span of tumour bearing animals was also increased. Thus in two models, S. lycopersicum extract exerted protective potential against skin tumors.
authors.affiliation: Department of Research, Jawaharlal Nehru Cancer Hospital and Research Centre, Bhopal, India. rcagrawal60@yahoo.com
authors.forename: R C
authors.initials: RC
authors.lastname: Agrawal
authors.forename: Rachana
authors.initials: R
authors.lastname: Jain
authors.forename: Wasim
authors.initials: W
authors.lastname: Raja
authors.forename: M
authors.initials: M
authors.lastname: Ovais
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene / Q000633:toxicity; D000818:Animals; D016588:Anticarcinogenic Agents / Q000627:therapeutic use*; D002273:Carcinogens / Q000633:toxicity; D003436:Croton Oil / Q000494:pharmacology; D005638:Fruit / Q000737:chemistry; D018551:Solanum lycopersicum / Q000737:chemistry*; D008297:Male; D008546:Melanoma, Experimental / Q000473:pathology / Q000517:prevention & control*; D051379:Mice; D008810:Mice, Inbred C57BL; D010212:Papilloma / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D012878:Skin Neoplasms / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D014407:Tumor Cells, Cultured
chemical_list: D016588:Anticarcinogenic Agents; D002273:Carcinogens; D010936:Plant Extracts; D015127:9,10-Dimethyl-1,2-benzanthracene; D003436:Croton Oil