[2.2]Paracyclophane-based monophosphine ligand for palladium-catalyzed cross-coupling reactions of aryl chlorides.
A new [2.2]paracyclophane-based electron-rich and sterically bulky monophosphine ligand has been synthesized by an efficient and straightforward method. When combined with palladium, this ligand shows excellent performance in the Buchwald-Hartwig amination and Suzuki-Miyaura coupling reactions of various aryl chlorides. In both types of reactions, ortho-substituted, deactivated aryl chlorides are shown to be viable substrates. However, the Suzuki-Miyaura coupling appears to be easier, with palladium loading at 0.1 mol% being feasible.
Ruan
Jiwu
J
Liverpool Centre for Materials and Catalysis, Department of Chemistry, University of Liverpool, Liverpool, L69 7ZD, UK.
Shearer
Lee
L
Mo
Jun
J
Bacsa
John
J
Zanotti-Gerosa
Antonio
A
Hancock
Fred
F
Wu
Xiaofeng
X
Xiao
Jianliang
J