The evolution of protein functions and networks: a family-centric approach.
The study of superfamilies of protein domains using a combination of structure, sequence and function data provides insights into deep evolutionary history. In the present paper, analyses of functional diversity within such superfamilies as defined in the CATH-Gene3D resource are described. These analyses focus on structure-function relationships in very large and diverse superfamilies, and on the evolution of domain superfamily members in protein-protein complexes.
Dessailly
Benoît H
BH
Department of Structural and Molecular Biology, University College London, London WC1E 6BT, UK.
Reid
Adam J
AJ
Yeats
Corin
C
Lees
Jonathan G
JG
Cuff
Alison
A
Orengo
Christine A
CA
D000818:Animals; D030562:Databases, Protein; D019143:Evolution, Molecular; D006801:Humans; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry* / Q000145:classification / Q000378:metabolism*; D013329:Structure-Activity Relationship
D011506:Proteins