title: Evidence-based review of clinical studies on trauma.
abstract: Clinical studies on trauma represent an important example of the ethical limitations of clinical research because patients cannot be randomized to "trauma" and "no trauma" groups. Instead, this important area of research includes preclinical studies, permitting more comprehensive experimental designs, case series/retrospective studies, and randomized studies in which the intervention focuses on treatment delivered after occurrence of dental trauma.
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D003746:Dental Enamel Proteins / Q000627:therapeutic use*; D055094:Evidence-Based Dentistry; D006801:Humans; D010865:Pilot Projects; D016032:Randomized Controlled Trials as Topic; D012390:Root Canal Therapy / Q000379:methods; D012391:Root Resorption / Q000517:prevention & control*; D000077596:Thymalfasin; D013947:Thymosin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D014084:Tooth Avulsion / Q000601:surgery*; D014090:Tooth Replantation; D016896:Treatment Outcome
chemical_list: D000276:Adjuvants, Immunologic; D003746:Dental Enamel Proteins; C109069:enamel matrix proteins; D013947:Thymosin; D000077596:Thymalfasin