[Surveillance for occult HBV infection and HBsAg variants in blood donors].
Occult hepatitis B virus (HBV) infection status of blood donors in a southern city in China was investigated by immunological assays and nucleic acid testing. Overall, 17 (0.19%, 95% CI: 0.11%-0.30%) of the 9023 HBsAg negative samples were found to be positive for the presence of HBV DNA. "A" epitope sequences were obtained from 14 among them. Mutation(s) in aa124-aa147 existed in 6 (42.9%, 6/14) samples and 4 (66.7%, 4/6)were G145R mutation. Ratio of genotype C in occult donors (10/17) was statistically higher than HBs-positive donors (0/15, P<0.01), which implied that HBV genotype C leaded to occult infection more easily.
Chen
Chang-rong
CR
Xiamen Blood Services, Xiamen 361004, China. zxxz@public.xm.fj.cn
Yuan
Quan
Q
Ge
Sheng-xiang
SX
Ou
Shan-hai
SH
Ni
Hong-ying
HY
Zhang
Yong-chang
YC
Pei
Bin
B
Li
An
A
Yan
Qiang
Q
Lin
Yong-cai
YC
Chen
Qing-rui
QR
Xia
Ning-shao
NS
Zhang
Jun
J
D000293:Adolescent; D000328:Adult; D001782:Blood Donors; D002681:China / Q000453:epidemiology; D004279:DNA, Viral / Q000235:genetics; D005260:Female; D005838:Genotype; D006509:Hepatitis B / Q000453:epidemiology* / Q000276:immunology / Q000821:virology; D006514:Hepatitis B Surface Antigens / Q000235:genetics / Q000276:immunology*; D006515:Hepatitis B virus / Q000145:classification / Q000235:genetics / Q000276:immunology / Q000502:physiology*; D006801:Humans; D007159:Immunologic Tests; D008297:Male; D009154:Mutation; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D055815:Young Adult
D004279:DNA, Viral; D006514:Hepatitis B Surface Antigens