Inhibitory activity of oxyresveratrol on wild-type and drug-resistant varicella-zoster virus replication in vitro.
The anti-herpes simplex virus (HSV) compound, oxyresveratrol, purified from a Thai traditional medicinal plant of Artocarpus lakoocha, was evaluated for its anti-varicella-zoster virus (VZV) activity. This compound exhibited IC(50) values (50%-inhibitory concentrations for virus plaque formation) of 12.82, 12.80, 12.99 and 12.82 microg/ml against wild type, thymidine kinase-deficient and two types of DNA polymerase mutants with acyclovir-resistance, respectively. Thus oxyresveratrol showed a broad spectrum of anti-VZV activity with a mechanism of action different from that of acyclovir.
Sasivimolphan
Pattaraporn
P
Department of Biochemistry and Microbiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Phayathai Road, Patumwan, Bangkok 10330, Thailand.
Lipipun
Vimolmas
V
Likhitwitayawuid
Kittisak
K
Takemoto
Masaya
M
Pramyothin
Pornpen
P
Hattori
Masao
M
Shiraki
Kimiyasu
K
D000998:Antiviral Agents / Q000494:pharmacology*; D002460:Cell Line; D002644:Chickenpox / Q000821:virology*; D024882:Drug Resistance, Viral; D014645:Herpesvirus 3, Human / Q000187:drug effects* / Q000235:genetics / Q000502:physiology; D006801:Humans; D010936:Plant Extracts / Q000494:pharmacology*; D013267:Stilbenes / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects*
D000998:Antiviral Agents; D010936:Plant Extracts; D013267:Stilbenes; C034912:puag-haad