title: Drug-induced sialorrhoea and excessive saliva accumulation.
abstract: (1) Sialorrhoea is the production of saliva that patients perceive as excessive; (2) Saliva accumulation is either due to a reduction in swallowing frequency or to an increase in saliva production; (3) Patients who drool may be ostracized, and there is also an increased risk of aspiration pneumonia; (4) Sialorrhoea can be caused by buccal, gastrointestinal or neurological disorders, or by drugs; (5) Sedatives such as benzodiazepines, neuroleptics, cholinesterase inhibitors and pilocarpine carry a dose-dependent risk of sialorrhoea; (6) In practice, the role of a drug should be borne in mind when a patient presents with sialorrhoea or excessive saliva accumulation. The parents of children treated with sedative drugs should be informed of this risk.
mesh_terms: D014150:Antipsychotic Agents / Q000009:adverse effects*; D001569:Benzodiazepines / Q000009:adverse effects*; D002800:Cholinesterase Inhibitors / Q000009:adverse effects*; D003024:Clozapine / Q000009:adverse effects*; D003680:Deglutition Disorders / Q000139:chemically induced; D000077265:Donepezil; D005702:Galantamine / Q000009:adverse effects; D006801:Humans; D006993:Hypnotics and Sedatives / Q000009:adverse effects*; D007189:Indans / Q000009:adverse effects; D048448:Phenylcarbamates / Q000009:adverse effects; D010862:Pilocarpine / Q000009:adverse effects; D010880:Piperidines / Q000009:adverse effects; D011788:Quality of Life; D018967:Risperidone / Q000009:adverse effects*; D000068836:Rivastigmine; D012798:Sialorrhea / Q000139:chemically induced*
chemical_list: D014150:Antipsychotic Agents; D002800:Cholinesterase Inhibitors; D006993:Hypnotics and Sedatives; D007189:Indans; D048448:Phenylcarbamates; D010880:Piperidines; D010862:Pilocarpine; D005702:Galantamine; D001569:Benzodiazepines; D000077265:Donepezil; D003024:Clozapine; D018967:Risperidone; D000068836:Rivastigmine