The rheological and thermal characteristics of freeze-thawed hydrogels containing hydrogen peroxide for potential wound healing applications.
The current study involves the development of a hydrogel carrier for a H(2)O(2) delivery system. In this work poly (vinyl alcohol) (PVA) and poly (acrylic acid) (PAA) based hydrogels were prepared, and their mechanical and physical properties examined. The novel aspect of this research is the differing functionality created by varying the concentration of H(2)O(2). The mechanical and thermal properties were determined by parallel plate rheometry and modulated differential scanning calorimetry (MDSC) respectively. The results indicated that the hydrogels containing H(2)O(2) are significantly weaker than those synthesised using water alone at test temperatures of 30 and 45 degrees C. MDSC analysis suggested that thermal transitions occur at temperatures that may make these hydrogels useful as temperature sensitive drug delivery systems. The chemical structure of the hydrogels was confirmed by means of attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), while swelling experiments in distilled water indicate that the swelling of the gels is temperature dependent.
Smith
Thomas J
TJ
Centre for Biopolymer and Biomolecular Research, Athlone Institute of Technology, Dublin Road, Athlone, Co. Westmeath, Ireland. tsmith@ait.ie
Kennedy
James E
JE
Higginbotham
Clement L
CL
D000180:Acrylic Resins / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D020100:Hydrogels / Q000737:chemistry*; D006861:Hydrogen Peroxide / Q000737:chemistry*; D011142:Polyvinyl Alcohol / Q000737:chemistry*; D012212:Rheology; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature; D013997:Time Factors; D014867:Water / Q000737:chemistry
D000180:Acrylic Resins; D020100:Hydrogels; D014867:Water; C006903:carbopol 940; D011142:Polyvinyl Alcohol; D006861:Hydrogen Peroxide