title: Use of a fibrinogen- and thrombin-coated patch for peptic ulcer perforation repair.
abstract: OBJECTIVE
  To present our experience with 2 patients treated with a fibrinogen- and thrombin-coated collagen patch to repair a perforated peptic ulcer.
  
  
  METHODS
  Age, sex, gastric disease, time between symptom appearance and operation, duration of operation, duration of nasogastric tube placement, renewal of peristalsis and feeding, and overall hospital stay were considered. Each patient underwent the laparotomic suture of the gastric wall, followed by patch application covered by the omental patch.
  
  
  RESULTS
  2 male patients underwent ulcer repair using the patch. The duration of the operation was 45 min. The nasogastric tube was kept in place for 3d and for 2d. The renewal of peristalsis occurred 12h after the operation in both patients. The patients started to eat 5d and 3d after the operation and were discharged after 6d and 4d, respectively.
  
  
  CONCLUSIONS
  The patch may improve the seal of the traditional repair, has no complications, and makes the overall operation faster.
authors.affiliation: Department of Surgical Sciences, Organ Transplantation and Advanced Technologies, University of Catania, Cannizzaro Hospital, Catania, Italy. idicarlo@unict.it
authors.forename: Isidoro
authors.initials: I
authors.lastname: Di Carlo
authors.forename: Elia
authors.initials: E
authors.lastname: Pulvirenti
authors.forename: Adriana
authors.initials: A
authors.lastname: Toro
mesh_terms: D020099:Coated Materials, Biocompatible / Q000627:therapeutic use; D004338:Drug Combinations; D005340:Fibrinogen / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010439:Peptic Ulcer Perforation / Q000473:pathology / Q000601:surgery*; D010528:Peristalsis; D020127:Recovery of Function; D013526:Surgical Mesh; D013917:Thrombin / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D020099:Coated Materials, Biocompatible; D004338:Drug Combinations; C518955:TachoSil; D005340:Fibrinogen; D013917:Thrombin