title: Malignancy in endometrial polyps: a 12-year experience.
abstract: OBJECTIVE
  Endometrial polyps (EPs) are common pathological lesions in all women. The objective of this study was to evaluate the risk of malignancy of EPs and to investigate whether clinical parameters may predict the histopathologic features of these lesions.
  
  
  METHODS
  A retrospective study was conducted from January 1995 to December 2006 and all consecutive 1242 cases with clinical EPs were included. The charts of all these women were reviewed and clinical data were related to histopathologic results.
  
  
  RESULTS
  Histologically, polyps were distinguished as benign, premalignant, and malignant. Overall, 95.2% benign polyps, 1.3% premalignant, and 3.5% malignant lesions were detected. When clinical variables were considered, patient age, menopause, presence of abnormal uterine bleeding, and hypertension were statistically significant characteristics related to premalignant and malignant features.
  
  
  CONCLUSIONS
  Older menopausal bleeding patients with hypertension are at high risk for premalignant and malignant polyps. Therefore, besides abnormal bleeding symptoms, this kind of patient needs to have the polyps removed.
authors.affiliation: Department of Gynecology and Obstetrics, Santa Maria della Misericordia University Hospital, Perugia, Italy.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Baiocchi
authors.forename: Natalina
authors.initials: N
authors.lastname: Manci
authors.forename: Michela
authors.initials: M
authors.lastname: Pazzaglia
authors.forename: Laura
authors.initials: L
authors.lastname: Giannone
authors.forename: Liliana
authors.initials: L
authors.lastname: Burnelli
authors.forename: Ettore
authors.initials: E
authors.lastname: Giannone
authors.forename: Daniela
authors.initials: D
authors.lastname: Fratini
authors.forename: Gian Carlo
authors.initials: GC
authors.lastname: Di Renzo
mesh_terms: D000328:Adult; D000368:Aged; D016889:Endometrial Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D011127:Polyps / Q000473:pathology*; D011230:Precancerous Conditions; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D055815:Young Adult