title: The impact of dystrobrevin-binding protein 1 (DTNBP1) on neural correlates of episodic memory encoding and retrieval.
abstract: Episodic memory impairment is a frequently reported symptom in schizophrenia. It has been shown to be associated with reduced neural activity of the hippocampus and prefrontal cortex. Given the high heritability of schizophrenia the question arises if alterations in brain activity are modulated by susceptibility genes and might be detectable in healthy risk allele carriers. The present study investigated the effect of the single nucleotide polymorphism (SNP) rs1018381 (P1578) of the dystrobrevin-binding protein 1 (DTNBP1) on brain activity in 84 healthy subjects assessed by functional magnetic resonance imaging (fMRI) while they performed an episodic memory task comprising encoding and retrieval of faces. During encoding, the group of risk allele carriers (n = 29) showed enhanced neural activity in the left middle frontal gyrus (BA 11) and bilaterally in the cuneus (BA 17, 7) when compared with the nonrisk carrier group (n = 55). During retrieval, the risk group (compared to the non risk group) showed increased right hemispheric neural activity comprising the medial frontal gyrus (BA 9), inferior frontal gyrus (BA 9), and inferior parietal lobule (BA 40). Since there were no behavioral performance differences, increased neural activity of the risk group might be interpreted as a correlate of higher effort or differing cognitive strategies in order to compensate for a genetically determined slight cognitive deficit. Interestingly, the laterality of increased prefrontal activity is in accordance with the well known hemispheric encoding/retrieval asymmetry (HERA) model of episodic memory.
authors.affiliation: Department of Psychiatry and Psychotherapy, RWTH Aachen University, 52074 Aachen, Germany. mthimm@ukaachen.de
authors.forename: Markus
authors.initials: M
authors.lastname: Thimm
authors.forename: Axel
authors.initials: A
authors.lastname: Krug
authors.forename: Valentin
authors.initials: V
authors.lastname: Markov
authors.forename: Sören
authors.initials: S
authors.lastname: Krach
authors.forename: Andreas
authors.initials: A
authors.lastname: Jansen
authors.forename: Klaus
authors.initials: K
authors.lastname: Zerres
authors.forename: Thomas
authors.initials: T
authors.lastname: Eggermann
authors.forename: Tony
authors.initials: T
authors.lastname: Stöcker
authors.forename: Nadim Jon
authors.initials: NJ
authors.lastname: Shah
authors.forename: Markus M
authors.initials: MM
authors.lastname: Nöthen
authors.forename: Marcella
authors.initials: M
authors.lastname: Rietschel
authors.forename: Tilo
authors.initials: T
authors.lastname: Kircher
mesh_terms: D000483:Alleles; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping; D002352:Carrier Proteins / Q000235:genetics* / Q000378:metabolism*; D000074765:Dysbindin; D049029:Dystrophin-Associated Proteins; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D011939:Mental Recall / Q000502:physiology*; D009483:Neuropsychological Tests; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D017422:Sequence Analysis, DNA; D055815:Young Adult
chemical_list: D002352:Carrier Proteins; C432416:DTNBP1 protein, human; D000074765:Dysbindin; D049029:Dystrophin-Associated Proteins