title: Image quality stability of whole-body diffusion weighted imaging.
abstract: OBJECTIVE
  To assess the reproducibility of whole-body diffusion weighted imaging (WB-DWI) technique in healthy volunteers under normal breathing with background body signal suppression.
  
  
  METHODS
  WB-DWI was performed on 32 healthy volunteers twice within two-week period using short TI inversion-recovery diffusion-weighted echo-planar imaging sequence and built-in body coil. The volunteers were scanned across six stations continuously covering the entire body from the head to the feet under normal breathing. The bone apparent diffusion coefficient (ADC) and exponential ADC (eADC) of regions of interest (ROIs) were measured. We analyzed correlation of the results using paired-t-test to assess the reproducibility of the WB-DWI technique.
  
  
  RESULTS
  We were successful in collecting and analyzing data of 64 WB-DWI images. There was no significant difference in bone ADC and eADC of 824 ROIs between the paired observers and paired scans (P>0.05). Most of the images from all stations were of diagnostic quality.
  
  
  CONCLUSIONS
  The measurements of bone ADC and eADC have good reproducibility. WB-DWI technique under normal breathing with background body signal suppression is adequate.
authors.affiliation: Department of Radiology, Fujian Medical University Teaching Hospital, Fujian Provincial Tumor Hospital, Fuzhou 350014, China. yunbinchen@126.com
authors.forename: Yun-bin
authors.initials: YB
authors.lastname: Chen
authors.forename: Chun-miao
authors.initials: CM
authors.lastname: Hu
authors.forename: Jing
authors.initials: J
authors.lastname: Zhong
authors.forename: Fei
authors.initials: F
authors.lastname: Sun
mesh_terms: D000328:Adult; D000368:Aged; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D017352:Echo-Planar Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012119:Respiration; D051598:Whole Body Imaging / Q000379:methods*