[Mechanisms of the respiratory activity of leptin at the level of the solitary tract nucleus].
In acute experiments on anaesthetised rats we investigated the effects of 10(-4) M leptin microinjected into the solitary tract nucleus on inspiratory-terminating Breuer-Hering reflex and ventilatory responses to hypercapnea. We found that the local administration of leptin into the area inhibited the inspiratory-terminating Breuer-Hering reflex. In contrast, ventilatory responses to hypercapnea were accentuated suggesting a modulatory effect of leptin on central chemoreceptors. The discovered physiological mechanisms are likely to play a key role for stimulating respiratory effects of leptin at the level of the solitary tract nucleus.
Iniushkina
E M
EM
Merkulova
N A
NA
Iniushkin
A N
AN
D000818:Animals; D004576:Electromyography; D005260:Female; D006935:Hypercapnia / Q000503:physiopathology; D020738:Leptin / Q000008:administration & dosage / Q000494:pharmacology* / Q000502:physiology; D008297:Male; D008845:Microinjections; D051381:Rats; D012026:Reflex, Stretch / Q000502:physiology; D012119:Respiration / Q000187:drug effects*; D012125:Respiratory Center / Q000187:drug effects / Q000502:physiology*; D017552:Solitary Nucleus / Q000187:drug effects / Q000502:physiology*
D020738:Leptin