Ileocecal histoplasmosis simulating Crohn disease in a patient with hyperimmunoglobulin E syndrome.
We describe a 14-year-old girl with hyperimmunoglobulin E (Job) syndrome who presented with fatigue, abdominal pain, fever, and weight loss. Endoscopic examination of the terminal ileum revealed ulceration, edema, and erythema. Histopathologic findings of the terminal ileum demonstrated intracellular yeast forms compatible with Histoplasma capsulatum. The patient was treated with oral itraconazole and had a rapid and complete response.
Steiner
Steven J
SJ
Division of Pediatric Gastroenterology/Hepatology/ Nutrition, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN 46202-5225, USA. ssteiner@inpui.edu
Kleiman
Martin B
MB
Corkins
Mark R
MR
Christenson
John C
JC
Wheat
L Joseph
LJ
D000293:Adolescent; D000935:Antifungal Agents / Q000627:therapeutic use; D002432:Cecum; D003424:Crohn Disease; D003937:Diagnosis, Differential; D005260:Female; D006658:Histoplasma / Q000302:isolation & purification; D006660:Histoplasmosis / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D007082:Ileum; D017964:Itraconazole / Q000627:therapeutic use; D007589:Job Syndrome / Q000150:complications*
D000935:Antifungal Agents; D017964:Itraconazole