title: Coeliac sprue-associated membranoproliferative glomerulonephritis (MPGN).
abstract: Coeliac sprue (CS) may occur in association with immune complex-mediated diseases, including IgA nephropathy, dermatitis herpetiformis and thyroiditis. An association of CS with membranoproliferative glomerulonephritis (MPGN) type 1 is rare, with only two prior cases reported. Here we describe a 45-year-old man with no prior medical history who presented initially with microhaematuria, subnephrotic proteinuria and hypocomplementaemia. A renal biopsy revealed MPGN type 1 with negative serologic workup for secondary causes. The patient was treated conservatively with angiotensin-converting enzyme inhibitors. Several months later, he developed daily non-bloody diarrhoea and was found to have worsening hypoalbuminaemia, hypophosphataemia and severe iron deficiency anaemia. A diagnosis of CS was established based on elevated tTGA (IgA anti-tissue transglutaminase) antibody and positive IgA antiendomysial antibody titres. Proteinuria resolved completely following the initiation of a gluten-free diet, without the use of immunosuppressive therapy and despite tapering of angiotensin-converting enzyme inhibitor. This case illustrates that CS-associated MPGN may precede overt clinical evidence of coeliac disease and may respond to gluten-free diet, without resort to immunosuppressive therapy.
authors.affiliation: Division of Nephrology and Hypertension, New York Presbyterian Hospital at Weill Cornell Medical Centre, College of Physicians and Surgeons, Columbia University, New York, NY, USA. Kdj200@gmail.com
authors.forename: Kenar D
authors.initials: KD
authors.lastname: Jhaveri
authors.forename: Vivette D
authors.initials: VD
authors.lastname: D'Agati
authors.forename: Robert
authors.initials: R
authors.lastname: Pursell
authors.forename: David
authors.initials: D
authors.lastname: Serur
mesh_terms: D002446:Celiac Disease / Q000150:complications* / Q000276:immunology / Q000628:therapy; D015432:Glomerulonephritis, Membranoproliferative / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007668:Kidney / Q000473:pathology; D008297:Male; D008875:Middle Aged
chemical_list: D007070:Immunoglobulin A