title: Foreign accent syndrome as a first sign of multiple sclerosis.
abstract: BACKGROUND
  Foreign accent syndrome (FAS) consists of a speech rhythm disorder different from dysarthia or aphasia. It is unusually met in multiple sclerosis (MS).
  
  
  OBJECTIVE
  We report a case of FAS as an initial symptom of a MS.
  
  
  METHODS
  A right-handed French woman developed an isolated German foreign accent. Brain magnetic resonance imaging (MRI), SPECT and analysis of CSF were performed.
  
  
  RESULTS
  Brain MRI revealed a large hypersignal on T2-weighted images in the left prerolandic white matter. Single photon emission computed tomography showed a right prerolandic hypoperfusion. Unmatched oligoclonal bands in cerebrospinal fluid and occurrence of new abnormal hypersignals on the following MRI led us to diagnose MS.
  
  
  CONCLUSIONS
  FAS may be the first symptom of MS. It could result from extensive disturbances of brain function involving the right hemisphere.
authors.affiliation: Service de Neurologie, Hôpital Civil, 1 place de l'Hôpital, Strasbourg, France. jb.chanson@hotmail.fr
authors.forename: J B
authors.initials: JB
authors.lastname: Chanson
authors.forename: S
authors.initials: S
authors.lastname: Kremer
authors.forename: F
authors.initials: F
authors.lastname: Blanc
authors.forename: C
authors.initials: C
authors.lastname: Marescaux
authors.forename: I J
authors.initials: IJ
authors.lastname: Namer
authors.forename: J
authors.initials: J
authors.lastname: de Seze
mesh_terms: D000328:Adult; D038524:Diffusion Magnetic Resonance Imaging; D004292:Dominance, Cerebral; D005260:Female; D006801:Humans; D009103:Multiple Sclerosis / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology; D010700:Phonetics; D013064:Speech Disorders / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology; D015899:Tomography, Emission-Computed, Single-Photon; D014705:Verbal Behavior