[ACTH activates in vitro protein kinases A and C in human adrenal cortex].
The activation of protein kinases A and C by corticotropin in the human adrenal cortex was analyzed. ACTH influence in vitro significantly increase protein kinase A activity, total protein kinase C activity in the membrane fraction of adrenocorticocytes and 11-hydroxycorticosteroids production of adrenal cortex tissue. Either cAMP-dependent protein kinase A or protein kinase C are included to postreceptoral messenger mechanism, that mediates ACTH action in adrenocortical cells.
Kovzun
O I
OI
Tron'ko
M D
MD
Mykosha
O S
OS
D000302:Adrenal Cortex / Q000187:drug effects* / Q000201:enzymology; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism*; D003600:Cytosol / Q000187:drug effects / Q000201:enzymology; D006801:Humans; D066298:In Vitro Techniques; D008861:Microsomes / Q000187:drug effects / Q000201:enzymology; D011493:Protein Kinase C / Q000378:metabolism*
D000324:Adrenocorticotropic Hormone; D017868:Cyclic AMP-Dependent Protein Kinases; D011493:Protein Kinase C