title: Surface plasmon resonance imaging for biosensing.
abstract: Surface plasmon resonance imaging (SPRI) is a useful tool for the study of surface biomolecular interactions allowing for label-free detection and elegant instrumentation. SPRI imaging system is described in this review with an emphasis on recent applications with examples of different biological interactions and high throughput analysis. Signal amplification in SPRI using nanoparticle and waveguide-based optical coupling is introduced. Finally the detection sensitivity of the SPRI system is examined in terms of other competitive methods.
authors.affiliation: Queen Mary, University of London, School of Engineering and Materials Science, London, UK.
authors.forename: S
authors.initials: S
authors.lastname: Paul
authors.forename: P
authors.initials: P
authors.lastname: Vadgama
authors.forename: A K
authors.initials: AK
authors.lastname: Ray
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods*; D004247:DNA / Q000737:chemistry; D011485:Protein Binding; D011506:Proteins / Q000737:chemistry; D012107:Research Design; D020349:Surface Plasmon Resonance / Q000295:instrumentation* / Q000379:methods*
chemical_list: D011506:Proteins; D004247:DNA