title: Extra-pulmonary small cell carcinoma of the neopharynx: case report and review of neopharyngeal tumours after total laryngectomy.
abstract: OBJECTIVE
  We report the first documented case in the world literature of primary extra-pulmonary small cell carcinoma occurring in the neopharynx following laryngectomy.
  
  
  METHODS
  We present a case report and a review of the world literature regarding the management of tumours of the neopharynx and extra-pulmonary small cell carcinoma.
  
  
  RESULTS
  The paucity of cases of extra-pulmonary small cell carcinoma has resulted in many departments managing this neoplasm similarly to pulmonary small cell cancer. However, the site of the primary can have an impact on disease survival and treatment options.
  
  
  CONCLUSIONS
  Neopharyngeal small cell carcinoma has not previously been reported. It should be managed in the same way as other extra-pulmonary small cell carcinomas occurring within the pharynx or larynx, with combined multi-drug chemotherapy and radiotherapy. Surgery has a limited role due to the aggressiveness of the disease and the high risk of local and distant spread at presentation.
authors.affiliation: Department of ENT, University Hospital of North Staffordshire, Stoke on Trent, UK. Georgea288@aol.com
authors.forename: A
authors.initials: A
authors.lastname: George
authors.forename: H
authors.initials: H
authors.lastname: Uppal
authors.forename: C
authors.initials: C
authors.lastname: Phelan
authors.forename: R
authors.initials: R
authors.lastname: Hughes
mesh_terms: D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000627:therapeutic use; D018288:Carcinoma, Small Cell / Q000175:diagnosis* / Q000532:radiotherapy; D003680:Deglutition Disorders / Q000209:etiology; D006801:Humans; D007822:Laryngeal Neoplasms / Q000601:surgery; D007825:Laryngectomy; D008297:Male; D009364:Neoplasm Recurrence, Local; D010610:Pharyngeal Neoplasms / Q000175:diagnosis* / Q000532:radiotherapy; D014057:Tomography, X-Ray Computed
chemical_list: D000970:Antineoplastic Agents