Cyclooxygenase-2 (COX-2) G-765C is a protective factor for coronary artery disease but not for ischemic stroke: a meta-analysis.
OBJECTIVE
Previous case-control studies suggested the single nucleotide polymorphism of cyclooxygenase-2 (COX-2) gene (G-765C) is associated with coronary artery disease (CAD) and ischemic stroke. However, other studies did not confirm this relationship. The objective was to assess the relationship of COX-2 G-765C and CAD and ischemic stroke, using a meta-analysis.


METHODS
Databases, including PubMed, EMbase, CBM and CNKI, were searched to get the genetic association studies. Data were extracted by two authors and pooled odds ratio (OR) with 95% confidence interval (CI) was calculated.


RESULTS
The meta-analysis included 4930 CAD patients and 17,997 controls, as well as 1628 ischemic stroke patients and 17,653 controls. For CAD, the pooled OR of -765C was 0.80 (95%CI: 0.65-0.98) compared to wild type allele in recessive model, and was 0.99 (95%CI: 0.92-1.06) in dominant model. For ischemic stroke, the pooled OR of -765C was 1.11 (95%CI: 0.88-1.42) in recessive model compared to wild type allele, and was 1.05 (95%CI: 0.93-1.18) in dominant model. No publication bias was found in this meta-analysis.


CONCLUSIONS
The synthesis of available evidence supports that the COX-2 G-765C is protective for CAD. However, it is not associated with ischemic stroke.
Li
Wenlong
W
Key Laboratory for Clinical Cardiovascular Genetics, Ministry of Education & Sino-German Laboratory for Molecular Medicine, Cardiovascular Institute & Fu Wai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, PR China.
Xu
Jing
J
Wang
Xiaojian
X
Chen
Jingzhou
J
Zhang
Channa
C
Sun
Kai
K
Hui
Rutai
R
D002545:Brain Ischemia / Q000201:enzymology / Q000235:genetics*; D016022:Case-Control Studies; D003327:Coronary Disease / Q000201:enzymology / Q000235:genetics* / Q000517:prevention & control; D051546:Cyclooxygenase 2 / Q000235:genetics*; D019317:Evidence-Based Medicine; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D018570:Risk Assessment; D012307:Risk Factors; D020521:Stroke / Q000201:enzymology / Q000235:genetics*
D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human