[Minimization or avoidance of calcineurin inhibitors after renal transplantation].
Calcineurin inhibitors (CNIs) are playing an important role in preventing acute rejection in renal transplantation; however, their nephrotoxicity may impact long-term renal allograft survival. Several CNI-sparing regimens (such as CNI-avoidance or CNI-minimization) have shown at least comparable efficacy with standard-dose CNI regimens. Research continues to achieve the "best" balance between efficacy and toxicity of available immunosuppressive regimens.
Xue
Chong
C
Department of Urology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
Ji
Zhi-gang
ZG
D065095:Calcineurin Inhibitors; D006084:Graft Rejection / Q000517:prevention & control; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage* / Q000009:adverse effects; D016030:Kidney Transplantation
D065095:Calcineurin Inhibitors; D007166:Immunosuppressive Agents