title: Minimizing limb amputations in meningococcal sepsis by early microsurgical arteriolysis.
abstract: OBJECTIVE
  Surgical treatment of children with meningococcal sepsis has mainly involved debridement of necrotic skin and amputation of limbs. This resulted in major functional impairment. On the contrary, when early microsurgical arteriolysis was performed, freeing up the blood vessels, the impaired blood flow could be restored, thereby significantly reducing the amputation levels.
  
  
  METHODS
  We prospectively evaluated 14 patients affected by meningococcal sepsis. In 7 patients, microsurgical arteriolysis was performed; standard sepsis treatment was performed on the remaining 7. Ischemia levels on admission were compared with permanent amputation levels after 1 year.
  
  
  RESULTS
  Statistically significant decreases (P = .005) in ischemia values were achieved by the arteriolysis, in comparison with final amputation percentages. The functional impairment of the affected limbs was highly reduced compared with the probable loss of function observed on admission.
  
  
  CONCLUSIONS
  Our findings show that early microsurgical arteriolysis is a reliable method to reduce the devastating amputations normally found in patients with meningococcal sepsis. This significantly improves the functional outcome in severely ischemic limbs in meningococcal induced septic children.
authors.affiliation: Department of Plastic Surgery, ULB Brussels University Hospital, Brussels, Belgium. w.boeckx@telenet.be
authors.forename: Willy D
authors.initials: WD
authors.lastname: Boeckx
authors.forename: Lloyd
authors.initials: L
authors.lastname: Nanhekhan
authors.forename: Gijs D
authors.initials: GD
authors.lastname: Vos
authors.forename: Piet
authors.initials: P
authors.lastname: Leroy
authors.forename: Eric
authors.initials: E
authors.lastname: Van den Kerckhove
mesh_terms: D000671:Amputation, Surgical / Q000706:statistics & numerical data*; D001132:Arm / Q000098:blood supply / Q000601:surgery*; D002675:Child, Preschool; D003646:Debridement; D005260:Female; D006801:Humans; D007223:Infant; D007511:Ischemia / Q000209:etiology / Q000601:surgery; D007866:Leg / Q000098:blood supply / Q000601:surgery*; D008297:Male; D008589:Meningococcal Infections / Q000150:complications / Q000601:surgery*; D008866:Microsurgery; D011446:Prospective Studies; D016896:Treatment Outcome; D014945:Wound Healing