Corallolides A and B: bioactive diterpenes featuring a novel carbon skeleton.
Corallolides A (1) and B (2) are naturally occurring diterpenes isolated from the Caribbean gorgonian octocoral Pseudopterogorgia bipinnata collected near Providencia Island, Colombia. Their tricyclic structures are based on a uniquely substituted bicyclo[9.2.1]tetradecane ring system that was established through detailed spectroscopic analysis. Compounds 1 and 2 were shown to exhibit antiparasitic and antituberculosis activity, respectively.
Ospina
Claudia A
CA
Department of Chemistry, University of Puerto Rico, P.O. Box 23346, UPR Station, San Juan, PR 00931-3346.
Rodríguez
Abimael D
AD
D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000995:Antitubercular Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D010963:Plasmodium falciparum / Q000187:drug effects*
D000962:Antimalarials; D000995:Antitubercular Agents; D004224:Diterpenes; C544892:corallolide A; C544893:corallolide B