title: Use of voriconazole in the surgical management of chronic postoperative fungal endophthalmitis.
abstract: Management of postoperative mycotic endophthalmitis remains challenging. This study reports successful management of postoperative chronic fungal endophthalmitis with vitrectomy surgery and voriconazole. A retrospective interventional case series of four eyes of four patients with chronic fungal endophthalmitis treated with pars plana vitrectomy and oral and intravitreal voriconazole is described. Pars plana vitrectomy, en bloc capsulectomy, and explantation of the intraocular lens were then performed combined with one to four intravitreal injections of voriconazole and oral voriconazole for up to 5 weeks. Identified fungal species included Aspergillus, Acremonium, Penicillium, and Verticillium. Voriconazole may have affected the clinical and surgical management of fungal endophthalmitis.
authors.affiliation: Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
authors.forename: Daniel V
authors.initials: DV
authors.lastname: Vasconcelos-Santos
authors.forename: Márcio B
authors.initials: MB
authors.lastname: Nehemy
mesh_terms: D000164:Acremonium / Q000302:isolation & purification; D000368:Aged; D000935:Antifungal Agents / Q000627:therapeutic use*; D001231:Aspergillus flavus / Q000302:isolation & purification; D002908:Chronic Disease; D003131:Combined Modality Therapy; D009877:Endophthalmitis / Q000188:drug therapy* / Q000382:microbiology; D015821:Eye Infections, Fungal / Q000188:drug therapy* / Q000382:microbiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009181:Mycoses / Q000188:drug therapy* / Q000382:microbiology; D010407:Penicillium / Q000302:isolation & purification; D018918:Phacoemulsification; D011183:Postoperative Complications; D011743:Pyrimidines / Q000627:therapeutic use*; D012189:Retrospective Studies; D014230:Triazoles / Q000627:therapeutic use*; D020172:Verticillium / Q000302:isolation & purification; D014792:Visual Acuity; D014821:Vitrectomy; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole