title: Anti-inflammatory, cyclooxygenase (COX)-2, COX-1 inhibitory and antioxidant effects of Dysophylla stellata Benth.
abstract: The n-hexane and ethyl acetate extracts of whole plants of Dysophylla stellata significantly inhibited edema when applied topically at doses of 0.5 and 1mg/ear in TPA-induced ear edema assay in mice. Further, both the extracts were evaluated for COX-1 and COX-2 inhibitory activities and showed 85.42 and 57.38%; and 71.79 and 89.27% inhibition at 50 microg/ml, respectively. Chromones (1 and 2) present in these extracts could be responsible for their COX-1 and COX-2 inhibitory and anti-inflammatory activities. The ethyl acetate extract showed antioxidant activity in DPPH and ABTS radical scavenging assay where as n-hexane extract found to be inactive.
authors.affiliation: Department of Natural Products, National Institute of Pharmaceutical Education and Research (NIPER), Sector - 67, SAS Nagar, Mohali - 160062 (Punjab), India.
authors.forename: Raju
authors.initials: R
authors.lastname: Gautam
authors.forename: Amit
authors.initials: A
authors.lastname: Srivastava
authors.forename: Sanjay M
authors.initials: SM
authors.lastname: Jachak
authors.forename: Arvind
authors.initials: A
authors.lastname: Saklani
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification*; D016861:Cyclooxygenase Inhibitors / Q000302:isolation & purification*; D004353:Drug Evaluation, Preclinical; D004487:Edema / Q000188:drug therapy*; D005260:Female; D019686:Lamiaceae / Q000737:chemistry*; D051379:Mice; D015394:Molecular Structure; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000627:therapeutic use*; D010946:Plants, Medicinal / Q000737:chemistry
chemical_list: D000893:Anti-Inflammatory Agents; D016861:Cyclooxygenase Inhibitors; D010936:Plant Extracts