title: Cardiolipin-enriched raft-like microdomains are essential activating platforms for apoptotic signals on mitochondria.
abstract: Cardiolipin (CL) has recently been shown to provide an anchor and an essential activating platform for caspase-8 on mitochondria. We hypothesize that these platforms may correspond to "raft-like" microdomains, which have demonstrated to be detectable on mitochondrial membrane of cells undergoing apoptosis. The role for CL in "raft-like" microdomains could be to anchor caspase-8 at contact sites between inner and outer membranes, facilitating its self-activation, Bid cleavage and apoptosis execution. The role played by "raft-like" microdomains in the apoptotic program could introduce a new task in the pathogenetic studies on human diseases associated with cardiolipin dismetabolism.
authors.affiliation: Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy. maurizio.sorice@uniroma1.it
authors.forename: Maurizio
authors.initials: M
authors.lastname: Sorice
authors.forename: Valeria
authors.initials: V
authors.lastname: Manganelli
authors.forename: Paola
authors.initials: P
authors.lastname: Matarrese
authors.forename: Antonella
authors.initials: A
authors.lastname: Tinari
authors.forename: Roberta
authors.initials: R
authors.lastname: Misasi
authors.forename: Walter
authors.initials: W
authors.lastname: Malorni
authors.forename: Tina
authors.initials: T
authors.lastname: Garofalo
mesh_terms: D017209:Apoptosis / Q000502:physiology*; D002308:Cardiolipins / Q000378:metabolism*; D006801:Humans; D021962:Membrane Microdomains / Q000737:chemistry / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism* / Q000648:ultrastructure; D051336:Mitochondrial Membranes / Q000737:chemistry / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology
chemical_list: D002308:Cardiolipins