The relationship between serum adiponectin level and anthropometry, bone mass, osteoporotic fracture risk in postmenopausal women.
OBJECTIVE
The aim of the present study was to evaluate the possible correlation between bone mass and serum adiponectin levels, and the correlation between adiponectin levels and osteoporotic fracture risk in a prospective clinical trial.


METHODS
Postmenopausal non-diabetic 105 women (mean age 63.4+/-8.1; range 52 to 64 years) with hip fracture were evaluated. Of these 105 patients, 46 had trochanteric fractures, 24 had subtrochanteric fractures and 35 had femoral neck fractures. Anthropometric measurements were performed. Serum adiponectin level was measured by means of ELISA. Total bone mineral density and bone mineral content of lumbar spine and proximal femur were measured by dual-energy X-ray absorptiometry (DEXA).


RESULTS
Lumbar bone mineral density and proximal femoral bone mineral density were not correlated with serum adiponectin levels. Serum adiponectin level was not found to have any significant effect on bone mass. Serum adiponectin levels were not significantly different between the patients with osteoporotic fractures and those with non-osteoporotic fractures.


CONCLUSIONS
Our study showed that serum adiponectin level is not associated with bone mass and osteoporotic fracture risk. Investigation of local adiponectin levels in bony tissue is needed to clarify the possible relation between adiponectin and bone mass, and risk of fractures associated with osteoporosis.
Ozkurt
Bülent
B
Department of 5th Orthopedics and Traumatology, Ankara Numune Education and Research Hospital, Ankara, Turkey. drbulentozkurt@yahoo.com
Ozkurt
Zübeyde Nur
ZN
Altay
Murat
M
Aktekin
Cem Nuri
CN
Cağlayan
Osman
O
Tabak
Yalçin
Y
D052242:Adiponectin / Q000097:blood*; D015519:Bone Density; D050723:Fractures, Bone / Q000453:epidemiology*; D006620:Hip Fractures / Q000097:blood*; D006801:Humans; D008875:Middle Aged; D010024:Osteoporosis / Q000453:epidemiology; D017698:Postmenopause; D012306:Risk
D052242:Adiponectin