EBV and genomic instability--a new look at the role of the virus in the pathogenesis of Burkitt's lymphoma.
Epidemiological and molecular evidence links Epstein-Barr virus (EBV) carriage to the pathogenesis of human malignancies of lymphoid and epithelial cell origin but the mechanisms of viral oncogenesis are poorly understood. Burkitt's lymphoma, a tumor occurring in both EBV-positive and -negative forms, provides a convenient model for analysis of the relative contribution of genetic changes and viral products that are expressed in the malignant cells. Here we review recent findings that highlight several mechanisms by which EBV could play an important role in oncogenesis by promoting genomic instability.
Gruhne
Bettina
B
Department of Cell and Molecular Biology, Karolinska Institutet, 17177 Stockholm, Sweden.
Kamranvar
Siamak Akbari
SA
Masucci
Maria G
MG
Sompallae
Ramakrishna
R
D000818:Animals; D002051:Burkitt Lymphoma / Q000821:virology*; D020031:Epstein-Barr Virus Infections / Q000821:virology*; D042822:Genomic Instability; D004854:Herpesvirus 4, Human / Q000502:physiology*; D006801:Humans