[Effect of a single emotional-pain stress on the basic carboxypeptidases activity in the rat brain regions and adrenals].
Effect of a single emotional-algesic stress on the carboxypeptidase H and PMSF-inhibited carboxypeptidase activities (phenylmethylsulphonilfluoride-inhibited carboxypeptidase) taking part in the final stage of formation of biologically active neuropeptides from precursors, was studied. Activity of the enzymes depended on duration of the stress and time after the stress in pituitary and adrenal glands. Differences in changes of carboxypeptidase H and PMSF-inhibited carboxypeptidase activities was found, especially in adrenals. The role of enzymes in emotional-algesic stress development and in metabolism of regulatory peptides by the stress was discussed.
Vernigora
A N
AN
Bardinova
Zh S
ZhS
Smetanin
V A
VA
Gengin
M T
MT
D000311:Adrenal Glands / Q000201:enzymology*; D000818:Animals; D001921:Brain / Q000201:enzymology*; D043423:Carboxypeptidase H / Q000037:antagonists & inhibitors / Q000378:metabolism*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D008297:Male; D009479:Neuropeptides / Q000378:metabolism; D010146:Pain / Q000150:complications / Q000201:enzymology*; D010664:Phenylmethylsulfonyl Fluoride / Q000494:pharmacology; D051381:Rats; D013315:Stress, Psychological / Q000150:complications / Q000201:enzymology*
D004791:Enzyme Inhibitors; D009479:Neuropeptides; D010664:Phenylmethylsulfonyl Fluoride; D043423:Carboxypeptidase H