Total synthesis and bioactivity of resolvin E2.
Resolvin E2 is a potent anti-inflammatory compound, derived from eicosapentaenoic acid. The efficient total synthesis of resolvin E2 by taking advantage of its intrinsic pseudoenantiomeric substructures is reported. The synthetic resolvin E2 proved to be biologically active in blocking neutrophil infiltration and reducing proinflammatory cytokines in the acute peritonitis model.
Ogawa
Seiji
S
Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Urabe
Daisuke
D
Yokokura
Yoshiyuki
Y
Arai
Hiroyuki
H
Arita
Makoto
M
Inoue
Masayuki
M
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D016207:Cytokines / Q000378:metabolism; D004195:Disease Models, Animal; D015118:Eicosapentaenoic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D051379:Mice; D020556:Neutrophil Infiltration / Q000187:drug effects; D010538:Peritonitis / Q000139:chemically induced; D013237:Stereoisomerism; D015054:Zymosan / Q000494:pharmacology
D000893:Anti-Inflammatory Agents; D016207:Cytokines; C517406:resolvin E2; D015054:Zymosan; D015118:Eicosapentaenoic Acid