Prediction of angiographic vasospasm after aneurysmal subarachnoid hemorrhage: value of the Hijdra sum scoring system.
BACKGROUND
Vasospasm is a major complication of aneurysmal subarachnoid hemorrhage (SAH) and affects clinical outcome. The ability to predict cerebral vasospasm after SAH would allow the neuro-intensivist to institute preemptive and more aggressive therapy.


METHODS
Social, clinical, and radiological information on adult SAH patients recently admitted to our hospital were reviewed. Univariate and multivariate statistical methods were used to examine the impact of patient demographics, clinical variables, and radiologic characteristics on the development of angiographic vasospasm.


RESULTS
One hundred and sixty three patients were identified (102 females, 63%). A total of 34 patients (21%) developed angiographic vasospasm. In univariate analysis, occurrence of cerebral vasospasm was associated with poor World Federation of Neurological Surgeons (WFNS 4-5, P = 0.003) and modified Fisher (MFS 3-4, P = 0.02) grades, elevated Hijdra sum score (HSS > or =23, P = 0.0001), female gender (P = 0.04), development of hydrocephalus (P = 0.01), and a history of tobacco use (P = 0.02). In multivariable analysis, only the HSS > or =23 (P = 0.01) and history of smoking (P = 0.02) predicted cerebral vasospasm. Combined history of smoking and HSS >23 had positive and negative predictive values of 37 and 88%, respectively, for prediction of cerebral vasospasm after aneurysmal hemorrhage.


CONCLUSIONS
Hijdra sum score and a history of smoking are the strongest predictors of cerebral vasospasm on angiography. HSS is superior to the MFS as a radiologic grading tool to predict occurrence of angiographic vasospasm after aneurysmal subarachnoid hemorrhage.
Dupont
Stefan A
SA
Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. dupont.stefan@mayo.edu
Wijdicks
Eelco F M
EF
Manno
Edward M
EM
Lanzino
Giuseppe
G
Rabinstein
Alejandro A
AA
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000150:complications* / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D012044:Regression Analysis; D012189:Retrospective Studies; D012307:Risk Factors; D012680:Sensitivity and Specificity; D012907:Smoking / Q000503:physiopathology; D013345:Subarachnoid Hemorrhage / Q000150:complications* / Q000000981:diagnostic imaging; D017585:Ultrasonography, Doppler, Transcranial; D020301:Vasospasm, Intracranial / Q000453:epidemiology*; D055815:Young Adult