title: Study on bone age in pediatric patients with congenital heart disease and its relation with cyanosis and pulmonary artery pressure.
abstract: The aim of this study is to evaluate the growth failure in children with Congenital Heart Diseases (CHD) associated with the Pulmonary Hypertension (PH) and cyanosis. Growth parameters including weight, height and head circumference of 120 cases with congenital heart defects aged 6 months to 14 years were compared with standard growth curves (50th percentile) between November 2007 and November, 2008. Of all, sixty five (54.1%) were male and 55 (45.8%) were female. The patients were classified into four groups based on the presence or absence of PH and cyanosis. The gap between chronological age and bone age (BA) for all subjects was determined. Growth disturbance in weight, height and head circumference was detected in 80 (66.7%), 79 (65.8%) and 41 (34.2%) of the patients, respectively. Bone age delay was seen in fifty five percent of the cases. Generally, delay in all parameters was more seen in acyanotic patients with pulmonary hypertension. In subjects with cyanosis whether in addition to PH or not, bone age was significantly retarded. Etiology of growth failure in children with CHD is multifactorial. Further studies are required to assess the role of different factors in this field.
authors.affiliation: Cardiovascular Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Samadi
authors.forename: R J
authors.initials: RJ
authors.lastname: Rashid
authors.forename: S
authors.initials: S
authors.lastname: Ghaffari
authors.forename: M
authors.initials: M
authors.lastname: Shoaran
mesh_terms: D000293:Adolescent; D000365:Age Determination by Skeleton; D002648:Child; D003430:Cross-Sectional Studies; D003490:Cyanosis / Q000209:etiology*; D005260:Female; D006130:Growth Disorders / Q000209:etiology / Q000503:physiopathology; D006330:Heart Defects, Congenital / Q000150:complications / Q000503:physiopathology; D006801:Humans; D006976:Hypertension, Pulmonary / Q000209:etiology*; D008297:Male; D055815:Young Adult