title: Effects of gastric medicines on gastroduodenal injury in patients with stable angina during antiplatelet therapy.
abstract: BACKGROUND
  The aim of this study was to examine the effects of gastric medicines on gastroduodenal injury during antiplatelet therapy after coronary intervention.
  
  
  METHODS
  A total of 501 patients were enrolled and as dual antiplatelet therapy, aspirin and thienopyridine were administered. Patients were divided into four groups: histamine H2-receptor antagonists (H2RA); proton pump inhibitors (PPI); other gastromucosal protective agents (GMP); or nothing (None), and follow-up lasted 8-20 months.
  
  
  RESULTS
  H2RA were prescribed in 212 cases (42%), PPI in 150 (30%), GMP in 56 (11%), and None in 83 (17%). Significant findings by endoscopy were recognized in 18 cases and upper gastrointestinal bleeding requiring hospitalization occurred in 7 patients (1.4%; H2RA in 4, GMP in 2, and None in 1). There were no gastrointestinal injuries in the PPI group. To minimize the effect of selection bias on gastroduodenal lesions, the propensity score analysis for clinical characteristics was used. The results of propensity score matching showed that administration of PPI reduced the incidence of gastrointestinal lesions compared with that of the non-PPI group.
  
  
  CONCLUSIONS
  Administration of PPI reduced the incidence of gastrointestinal lesions compared with that of the non-PPI group.
authors.affiliation: Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1, Honjo, Kumamoto 860-8556, Japan. aogimoto@m.ehime-u.ac.jp
authors.forename: Seiji
authors.initials: S
authors.lastname: Hokimoto
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Matsui
authors.forename: Shuichi
authors.initials: S
authors.lastname: Oshima
authors.forename: Katsuo
authors.initials: K
authors.lastname: Noda
authors.forename: Koichi
authors.initials: K
authors.lastname: Kaikita
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Sumida
authors.forename: Seigo
authors.initials: S
authors.lastname: Sugiyama
authors.forename: Hisao
authors.initials: H
authors.lastname: Ogawa
mesh_terms: D000368:Aged; D000787:Angina Pectoris / Q000188:drug therapy*; D015906:Angioplasty, Balloon, Coronary; D001241:Aspirin / Q000009:adverse effects; D005260:Female; D005500:Follow-Up Studies; D005753:Gastric Mucosa / Q000187:drug effects*; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced; D006635:Histamine H2 Antagonists / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D010437:Peptic Ulcer / Q000139:chemically induced* / Q000517:prevention & control*; D010975:Platelet Aggregation Inhibitors / Q000009:adverse effects*; D057216:Propensity Score; D054328:Proton Pump Inhibitors / Q000627:therapeutic use*; D011725:Pyridines / Q000009:adverse effects; D015607:Stents
chemical_list: D006635:Histamine H2 Antagonists; D010975:Platelet Aggregation Inhibitors; D054328:Proton Pump Inhibitors; D011725:Pyridines; C446540:thienopyridine; D001241:Aspirin