NMR assignment and secondary structure of human growth arrest and DNA damage alpha protein (Gadd45 alpha).
Gadd45 alpha is a predominantly nuclear protein encoded by a DNA-damage-inducible gene which is transcriptionally regulated by the tumor suppressor p53. The interactions of Gadd45 alpha with several other proteins play a central role in DNA repair, cell cycle control and apoptosis. The NMR assignments of human Gadd45 alpha protein reported here provide the basis for further characterization of these interactions.
Sánchez
Ricardo
R
Structural Biology Unit, CIC Biogune, Parque Tecnológico de Bizkaia, Ed. 800, Derio, 48160, Spain.
Pantoja-Uceda
David
D
Torres
Daniel
D
Prieto
Jesús
J
Campos-Olivas
Ramón
R
Blanco
Francisco J
FJ
D000595:Amino Acid Sequence; D001665:Binding Sites; D002247:Carbon Isotopes / Q000737:chemistry; D018797:Cell Cycle Proteins / Q000737:chemistry* / Q000648:ultrastructure*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008969:Molecular Sequence Data; D008970:Molecular Weight; D009587:Nitrogen Isotopes / Q000737:chemistry; D009687:Nuclear Proteins / Q000737:chemistry* / Q000648:ultrastructure*; D011485:Protein Binding; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D011522:Protons; D000097642:GADD45 Proteins
D002247:Carbon Isotopes; D018797:Cell Cycle Proteins; D009587:Nitrogen Isotopes; D009687:Nuclear Proteins; D011522:Protons; C439070:GADD45A protein, human; D000097642:GADD45 Proteins