title: Findings on serial surveillance colonoscopy in patients with low-risk polyps on initial colonoscopy.
abstract: OBJECTIVE
  This study describes the prevalence of adenomatous polyps at serial follow-up exams after a colonoscopy finding 1 to 2 small tubular adenomas.
  
  
  METHODS
  We conducted a retrospective cohort of patients with 1 to 2 small tubular adenomas on an initial colonoscopy who underwent at least 2 additional surveillance examinations. Our primary outcome was any or advanced adenomas on the third colonoscopy.
  
  
  RESULTS
  Eighty-eight patients met inclusion criteria. At the second and third colonoscopy, 31/88 (35.2%) patients and 26/88 (29.6%) patients had at least 1 adenoma, respectively. Among the 28 patients with 1 to 2 small tubular adenomas on colonoscopy no. 2, the prevalence of any adenomas on colonoscopy no. 3 was 39.3% [95% confidence interval (CI): 21.5%-59.4%]. Among the 56 patients without adenomas at colonoscopy no. 2, the prevalence of any and advanced adenomas on colonoscopy no. 3 was 25% (95% CI: 14.4%-38.4%), and 3.6% (95% CI: 0.4%-12.3%), respectively.
  
  
  CONCLUSIONS
  In patients with 1-2 small tubular adenomas on initial colonoscopy the prevalence of adenomas and advanced lesions on the third colonoscopy remains high even if no adenomas are found on the second colonoscopy.
authors.affiliation: Division of Gastroenterology, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
authors.forename: Jocelyne
authors.initials: J
authors.lastname: Miller
authors.forename: Neil
authors.initials: N
authors.lastname: Mehta
authors.forename: Michael
authors.initials: M
authors.lastname: Feldman
authors.forename: Emma
authors.initials: E
authors.lastname: Furth
authors.forename: Gregory G
authors.initials: GG
authors.lastname: Ginsberg
authors.forename: Yu-Xiao
authors.initials: YX
authors.lastname: Yang
authors.forename: James D
authors.initials: JD
authors.lastname: Lewis
mesh_terms: D000236:Adenoma / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D003110:Colonic Neoplasms / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology; D003111:Colonic Polyps / Q000175:diagnosis* / Q000473:pathology; D003113:Colonoscopy / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008403:Mass Screening / Q000379:methods; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies; D013997:Time Factors