Growth patterns in children with intrauterine growth retardation and their correlation to neurocognitive development.
The relationship between somatic growth and neurocognitive outcome was studied in a cohort of 136 children with intrauterine growth retardation. The children were followed up from birth to 9 to 10 years of age by annual measurements of growth parameters, neurodevelopmental evaluations, and IQ. The rate of catch-up for height between 1 and 2 years of age was significantly higher than the catch-up for weight (P < .001). The cognitive outcome at 9 to 10 years correlated with head circumference at all ages. The neurodevelopmental outcome at 9 to 10 years correlated with weight at all ages. Correlation with head circumference was more significant with IQ, while with weight it was stronger with the neurodevelopmental score. Height at 1 year was a significant predictor for IQ and neurodevelopmental outcome at 9 to 10 years. These findings are of distinct importance for prediction of subsequent neurodevelopmental outcome in children with intrauterine growth retardation.
Fattal-Valevski
Aviva
A
Institute for Child Development and Pediatric Neurology Unit, Tel Aviv Sourasky Medical Center affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Israel. afatal@post.tau.ac.il
Toledano-Alhadef
Hagit
H
Leitner
Yael
Y
Geva
Ronny
R
Eshel
Rina
R
Harel
Shaul
S
D001827:Body Height; D001835:Body Weight; D002508:Cephalometry; D002648:Child; D002657:Child Development; D002675:Child, Preschool; D003071:Cognition; D005317:Fetal Growth Retardation; D005500:Follow-Up Studies; D005865:Gestational Age; D006257:Head / Q000254:growth & development; D006801:Humans; D007223:Infant; D007230:Infant, Low Birth Weight / Q000254:growth & development* / Q000523:psychology*; D007231:Infant, Newborn; D007360:Intelligence; D007361:Intelligence Tests; D009483:Neuropsychological Tests; D011446:Prospective Studies