Drug-induced acute pancreatitis in children receiving chemotherapy for acute leukemia: does propofol increase the risk?
BACKGROUND
The use of propofol is controversial in patients with a history of acute pancreatitis or those taking drugs, including certain chemotherapeutic drugs, that are associated with pancreatitis.


METHODS
To investigate this issue, we reviewed the medical records of all children who were diagnosed with pancreatitis while receiving chemotherapy for acute leukemia during a 5-year period.


RESULTS
A temporal relationship between propofol use and development of acute pancreatitis could not be established.


CONCLUSIONS
Propofol can be considered for general anesthesia in children who are receiving chemotherapeutic drugs that are themselves associated with acute pancreatitis or those who have a history of chemotherapy-induced pancreatitis.
Crawford
Mark W
MW
Department of Anesthesia and Pain Medicine, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada. mark.crawford@sickkids.c
Pehora
Carolyne
C
Lopez
Alejandra V
AV
D000208:Acute Disease; D000293:Adolescent; D000768:Anesthesia, General / Q000009:adverse effects; D018686:Anesthetics, Intravenous / Q000009:adverse effects*; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007431:Intraoperative Complications / Q000453:epidemiology; D007938:Leukemia / Q000150:complications* / Q000188:drug therapy; D008297:Male; D010195:Pancreatitis / Q000139:chemically induced* / Q000453:epidemiology*; D015742:Propofol / Q000009:adverse effects*; D018570:Risk Assessment
D018686:Anesthetics, Intravenous; D000970:Antineoplastic Agents; D015742:Propofol