title: Tyrosinase inhibitor activity of coumarin-resveratrol hybrids.
abstract: In the present work we report on the contribution of the coumarin moiety to tyrosinase inhibition. Coumarin-resveratrol hybrids 1-8 have been resynthesized to investigate the structure-activity relationships and the IC(50) values of these compounds were measured. The results showed that these compounds exhibited tyrosinase inhibitory activity. Compound 3-(3',4',5'-trihydroxyphenyl)-6,8-dihydroxycoumarin (8)is the most potentcompound (0.27 mM), more so than umbelliferone (0.42 mM), used as reference compound. The kinetic studies revealed that compound 8 caused non-competitive tyrosinase inhibition.
authors.affiliation: Dipartimento Scienze Applicate ai Biosistemi, Università degli Studi di Cagliari, Cittadella Universitaria di Monserrato, S.S. 554 Km 0.700 bivio per Sestu, 09042 Monserrato, CA, Italy. fais@unica.it
authors.forename: Antonella
authors.initials: A
authors.lastname: Fais
authors.forename: Marcella
authors.initials: M
authors.lastname: Corda
authors.forename: Benedetta
authors.initials: B
authors.lastname: Era
authors.forename: M Benedetta
authors.initials: MB
authors.lastname: Fadda
authors.forename: Maria Joao
authors.initials: MJ
authors.lastname: Matos
authors.forename: Elias
authors.initials: E
authors.lastname: Quezada
authors.forename: Lourdes
authors.initials: L
authors.lastname: Santana
authors.forename: Carmen
authors.initials: C
authors.lastname: Picciau
authors.forename: Gianni
authors.initials: G
authors.lastname: Podda
authors.forename: Giovanna
authors.initials: G
authors.lastname: Delogu
mesh_terms: D003374:Coumarins / Q000737:chemistry / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors*; D000077185:Resveratrol; D013267:Stilbenes / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D003374:Coumarins; D004791:Enzyme Inhibitors; D013267:Stilbenes; C030123:coumarin; D014442:Monophenol Monooxygenase; D000077185:Resveratrol