title: Hemispheric lateralization of the corticostriatal glutamatergic system in the rat.
abstract: Little is known about hemispheric lateralization of subcortical structures. Here, we show a higher expression of the subunit NR2A of the NMDA receptor mRNA in the striatum and of vGluT1 mRNA in the cingulate cortex, in the left hemisphere compared to the right one. This suggests a lateralization of the glutamatergic cortico-subcortical system, at the level of postsynaptic receptors as well as at the level of corticostriatal projections. Such lateralization could play a role in asymmetric diseases like Parkinson's disease.
authors.affiliation: Department of Neurology and Department of Clinical Research, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
authors.forename: Christine
authors.initials: C
authors.lastname: Capper-Loup
authors.forename: Dominik
authors.initials: D
authors.lastname: Rebell
authors.forename: Alain
authors.initials: A
authors.lastname: Kaelin-Lang
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism*; D003342:Corpus Striatum / Q000378:metabolism*; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D009434:Neural Pathways / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D016194:Receptors, N-Methyl-D-Aspartate / Q000235:genetics / Q000378:metabolism*; D050598:Vesicular Glutamate Transport Protein 1 / Q000235:genetics / Q000378:metabolism*
chemical_list: C120997:NR2A NMDA receptor; C121001:NR2B NMDA receptor; D012333:RNA, Messenger; D016194:Receptors, N-Methyl-D-Aspartate; C493466:Slc17a7 protein, rat; D050598:Vesicular Glutamate Transport Protein 1