title: Effect of grape seed extract on blood pressure in subjects with the metabolic syndrome.
abstract: This study was undertaken to determine whether grape seed extracts (GSE) that contain powerful vasodilator phenolic compounds lower blood pressure in subjects with the metabolic syndrome. The subjects were randomized into 3 groups-(a) placebo, (b) 150 mg GSE per day, and (c) 300 mg GSE per day-and treated for 4 weeks. Serum lipids and blood glucose were measured at the beginning of the study and at the end. Blood pressure was recorded using an ambulatory monitoring device at the start of the treatment period and at the end. Both the systolic and diastolic blood pressures were lowered after treatment with GSE as compared with placebo. There were no significant changes in serum lipids or blood glucose values. These findings suggest that GSE could be used as a nutraceutical in a lifestyle modification program for patients with the metabolic syndrome.
authors.affiliation: Department of Internal Medicine, University of California Davis, Davis, CA 95616, USA.
authors.forename: Brahmesh
authors.initials: B
authors.lastname: Sivaprakasapillai
authors.forename: Indika
authors.initials: I
authors.lastname: Edirisinghe
authors.forename: Jody
authors.initials: J
authors.lastname: Randolph
authors.forename: Francene
authors.initials: F
authors.lastname: Steinberg
authors.forename: Tissa
authors.initials: T
authors.lastname: Kappagoda
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001774:Blood Chemical Analysis; D001794:Blood Pressure / Q000187:drug effects*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004032:Diet; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000503:physiopathology*; D008875:Middle Aged; D009043:Motor Activity; D010936:Plant Extracts / Q000494:pharmacology; D012639:Seeds / Q000737:chemistry; D027843:Vitis / Q000737:chemistry*
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D010936:Plant Extracts