[Genetic profile of gastroenteropancreatic neuroendocrine tumors].
Gastroenteropancreatic neuroendocrine tumors are relatively rare neoplasms but their incidence has significantly increased in the last 30 years. These tumors are usually sporadic but can also occur as part of certain endocrine tumor susceptibility syndromes such as multiple endocrine neoplasia type1 (MEN1) and von Hippel Lindau disease. The genetic abnormalities associated with the development or progression of these tumors depend on the site of origin and suggest multiple gene involvement. Knowledge of this genetic complex has been gained from a variety of approaches such as comparative genomic hybridization, loss of heterozygosity and DNA microarray analysis. These genetic studies indicate that pancreatic endocrine tumors frequently harbor mutations in the MEN1 gene, among others, and that carcinoid tumors, in contrast, show more alterations on chromosome 18. Nevertheless, the molecular pathogenesis of gastroenteropancreatic neuroendocrine tumors remains to be fully elucidated, mainly because the data refer to small and heterogeneous tumor series.
Cabezas Agrícola
José M
JM
Servicio de Endocrinología y Nutrición, Complejo Hospitalario Universitario de Santiago (C.H.U.S.), Santiago de Compostela, España. jose.manuel.cabezas.agricola@sergas.es
D006801:Humans; D007414:Intestinal Neoplasms / Q000235:genetics; D018358:Neuroendocrine Tumors / Q000235:genetics; D010190:Pancreatic Neoplasms / Q000235:genetics; D013274:Stomach Neoplasms / Q000235:genetics