A randomized trial comparing sevoflurane and propofol in children undergoing MRI scans.
OBJECTIVE
We compared three primary outcomes of pausing the magnetic resonance imaging (MRI) scan, emergence quality and respiratory complications.


OBJECTIVE
To measure and compare the quality between sevoflurane and propofol in children undergoing MRI scans.


BACKGROUND
No randomized controlled trial exists comparing the quality between sevoflurane and propofol for MRI.


METHODS
Two hundred unpremedicated children (18 months to 7 years) scheduled for brain MRI scans were recruited. After induction with sevoflurane, children were randomized to receive sevoflurane [general anesthesia with sevoflurane (GAS)] via laryngeal mask airway (LMA) or propofol [general anesthesia with propofol (GAP)] bolus and infusion for their scan. The three primary outcomes of pausing the MRI scan (P), agitation (A), and respiratory complications (R) were compared. Timeliness of care was also measured.


RESULTS
No MRI scan pauses were found in 92% and 80% in the GAS and GAP groups. The median and interquartile A scores were 3 (0, 7) in GAS and 0 (0, 4) in GAP groups respectively. There was no difference in respiratory complications between GAS and GAP (P = 0.62). The median and interquartile postanesthesia care unit (PACU) times were 25 (18, 34) for GAS and 31 (25, 44) for GAP (P = 0.0001). The median and interquartile total times were 78 (69, 90) for GAS and 88 (78, 100) for GAP (P = 0.0002).


CONCLUSIONS
Our study compared the three primary outcomes of pausing, agitation, and respiratory complications between the two groups, and we found no difference in respiratory complications. However, the GAP group had more pausing and less agitation than the GAS group.
Bryan
Yvon F
YF
Department of Anesthesiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1009, USA. ybryan@wfubmc.edu
Hoke
Lauren K
LK
Taghon
Thomas A
TA
Nick
Todd G
TG
Wang
Yu
Y
Kennedy
Stephanie M
SM
Furstein
James S
JS
Kurth
Charles Dean
CD
D000465:Algorithms; D000768:Anesthesia, General / Q000009:adverse effects; D000769:Anesthesia, Inhalation / Q000009:adverse effects; D000771:Anesthesia, Intravenous / Q000009:adverse effects; D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D001049:Apnea / Q000517:prevention & control; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007442:Intubation, Intratracheal; D008279:Magnetic Resonance Imaging; D008297:Male; D008738:Methyl Ethers; D009068:Movement; D015742:Propofol; D011595:Psychomotor Agitation / Q000517:prevention & control / Q000523:psychology; D011787:Quality of Health Care; D015656:Respiratory Mechanics / Q000187:drug effects; D000077149:Sevoflurane; D016896:Treatment Outcome
D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D008738:Methyl Ethers; D000077149:Sevoflurane; D015742:Propofol