title: Molecularly imprinted polymers--tyrosinase mimics.
abstract: Synthetic polymers mimicking the enzyme tyrosinase have been prepared by the molecular imprinting of a complex between Cu (II) and catechol and ethyl ester of urocanic acid in an ethylene glycol dimethacrylate copolymer. Optimised polymer systems demonstrated catalysis, Michaelis-Menten kinetics and competitive inhibition similar to those of mushroom tyrosinase. The polymers benefited from superior chemical and mechanical stability in comparison with natural enzyme.
authors.affiliation: Institute of Bioscience and Technology, Cranfield University, UK.
authors.forename: S A
authors.initials: SA
authors.lastname: Piletsky
authors.forename: I A
authors.initials: IA
authors.lastname: Nicholls
authors.forename: M I
authors.initials: MI
authors.lastname: Rozhko
authors.forename: T A
authors.initials: TA
authors.lastname: Sergeyeva
authors.forename: E V
authors.initials: EV
authors.lastname: Piletska
authors.forename: A V
authors.initials: AV
authors.lastname: El Skaya
authors.forename: I
authors.initials: I
authors.lastname: Karube
mesh_terms: D003432:Cross-Linking Reagents / Q000138:chemical synthesis* / Q000737:chemistry; D054802:Molecular Imprinting; D018716:Molecular Mimicry; D015394:Molecular Structure; D014442:Monophenol Monooxygenase / Q000737:chemistry*; D010084:Oxidation-Reduction; D044367:Phase Transition; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D003432:Cross-Linking Reagents; D011108:Polymers; D014442:Monophenol Monooxygenase