Diversity in long-term synaptic plasticity at inhibitory synapses of striatal spiny neurons.
Procedural memories and habits are posited to be stored in the basal ganglia, whose intrinsic circuitries possess important inhibitory connections arising from striatal spiny neurons. However, no information about long-term plasticity at these synapses is available. Therefore, this work describes a novel postsynaptically dependent long-term potentiation (LTP) at synapses among spiny neurons (intrinsic striatal circuitry); a postsynaptically dependent long-term depression (LTD) at synapses between spiny and pallidal neurons (indirect pathway); and a presynaptically dependent LTP at strionigral synapses (direct pathway). Interestingly, long-term synaptic plasticity differs at these synapses. The functional consequences of these long-term plasticity variations during learning of procedural memories are discussed.
Rueda-Orozco
Pavel E
PE
Departamento de Biofísica, Instituto de Fisiologia Celular-Neurociencias, Universidad Nacional Autonoma de México, México City, Distrito Federal, Mexico 04510.
Mendoza
Ernesto
E
Hernandez
Ricardo
R
Aceves
Jose J
JJ
Ibanez-Sandoval
Osvaldo
O
Galarraga
Elvira
E
Bargas
Jose
J
D000818:Animals; D001479:Basal Ganglia / Q000166:cytology / Q000502:physiology*; D066298:In Vitro Techniques; D017774:Long-Term Potentiation / Q000502:physiology*; D036881:Long-Term Synaptic Depression / Q000502:physiology*; D009433:Neural Inhibition / Q000502:physiology; D009434:Neural Pathways / Q000166:cytology / Q000502:physiology; D009473:Neuronal Plasticity / Q000502:physiology*; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D055366:Synaptic Potentials / Q000502:physiology