title: Early molecular events in PAMP-triggered immunity.
abstract: In plant innate immunity, the first line of microbial recognition leading to active defence responses relies on the perception of pathogen-associated molecular patterns (PAMPs) by pattern-recognition receptors (PRRs). This recognition leads to PAMP-triggered immunity (PTI). Despite the numerous PAMPs recognised by plants, only a handful of PRRs are characterised. For most, they correspond to transmembrane proteins with a ligand-binding ectodomain. PRRs interact with additional transmembrane proteins that act as signalling adapters or amplifiers to achieve full functionality. The crucial role of PRRs in anti-microbial immunity is demonstrated by the direct targeting of PRRs and their associated proteins by pathogenic virulence effectors.
authors.affiliation: The Sainsbury Laboratory, Colney Lane, Norwich, UK. cyril.zipfel@tsl.ac.uk
authors.forename: Cyril
authors.initials: C
authors.lastname: Zipfel
mesh_terms: D054884:Host-Pathogen Interactions; D007113:Immunity, Innate; D008565:Membrane Proteins / Q000378:metabolism*; D008954:Models, Biological; D010935:Plant Diseases / Q000382:microbiology; D010940:Plant Proteins / Q000378:metabolism*; D010944:Plants / Q000378:metabolism* / Q000382:microbiology; D011485:Protein Binding; D051192:Receptors, Pattern Recognition / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D008565:Membrane Proteins; D010940:Plant Proteins; D051192:Receptors, Pattern Recognition