title: Prostate cancer detection with multi-parametric MRI: logistic regression analysis of quantitative T2, diffusion-weighted imaging, and dynamic contrast-enhanced MRI.
abstract: OBJECTIVE
  To develop a multi-parametric model suitable for prospectively identifying prostate cancer in peripheral zone (PZ) using magnetic resonance imaging (MRI).
  
  
  METHODS
  Twenty-five radical prostatectomy patients (median age, 63 years; range, 44-72 years) had T2-weighted, diffusion-weighted imaging (DWI), T2-mapping, and dynamic contrast-enhanced (DCE) MRI at 1.5 Tesla (T) with endorectal coil to yield parameters apparent diffusion coefficient (ADC), T2, volume transfer constant (K(trans)) and extravascular extracellular volume fraction (v(e)). Whole-mount histology was generated from surgical specimens and PZ tumors delineated. Thirty-eight tumor outlines, one per tumor, and pathologically normal PZ regions were transferred to MR images. Receiver operating characteristic (ROC) curves were generated using all identified normal and tumor voxels. Step-wise logistic-regression modeling was performed, testing changes in deviance for significance. Areas under the ROC curves (A(z)) were used to evaluate and compare performance.
  
  
  RESULTS
  The best-performing single-parameter was ADC (mean A(z) [95% confidence interval]: A(z,ADC): 0.689 [0.675, 0.702]; A(z,T2): 0.673 [0.659, 0.687]; A(z,Ktrans): 0.592 [0.578, 0.606]; A(z,ve): 0.543 [0.528, 0.557]). The optimal multi-parametric model, LR-3p, consisted of combining ADC, T2 and K(trans). Mean A(z,LR-3p) was 0.706 [0.692, 0.719], which was significantly higher than A(z,T2), A(z,Ktrans), and A(z,ve) (P < 0.002). A(z,LR-3p) tended to be greater than A(z,ADC), however, this result was not statistically significant (P = 0.090).
  
  
  CONCLUSIONS
  Using logistic regression, an objective model capable of mapping PZ tumor with reasonable performance can be constructed.
authors.affiliation: Department of Medical Imaging, Princess Margaret Hospital, University Health Network and Mount Sinai Hospital, Toronto, Ontario, Canada.
authors.forename: Deanna L
authors.initials: DL
authors.lastname: Langer
authors.forename: Theodorus H
authors.initials: TH
authors.lastname: van der Kwast
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Evans
authors.forename: John
authors.initials: J
authors.lastname: Trachtenberg
authors.forename: Brian C
authors.initials: BC
authors.lastname: Wilson
authors.forename: Masoom A
authors.initials: MA
authors.lastname: Haider
mesh_terms: D000328:Adult; D000368:Aged; D003287:Contrast Media; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000601:surgery; D012372:ROC Curve
chemical_list: D003287:Contrast Media