title: Good syndrome accompanied by pure red cell aplasia.
abstract: Thymomas are often associated with various autoimmune disorders. We herein report a middle-aged female patient with thymoma and hypogammaglobulinemia (Good syndrome) who developed symptomatic normocytic anemia. Her computed tomography (CT) scans showed a cervico-mediastinal mass. The findings of a bone marrow biopsy suggested pure red cell aplasia (PRCA), and the serum levels of all immunoglobulins were extremely low. After the resection of the tumor, which was diagnosed to be Masaoka stage II and type AB thymoma, the normocytic anemia dramatically improved, but the hypogammaglobulinemia did not recover.
authors.affiliation: Division of Thoracic Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan. ttani@med.nagoya-u.ac.jp
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Taniguchi
authors.forename: Noriyasu
authors.initials: N
authors.lastname: Usami
authors.forename: Koji
authors.initials: K
authors.lastname: Kawaguchi
authors.forename: Kohei
authors.initials: K
authors.lastname: Yokoi
mesh_terms: D000328:Adult; D000361:Agammaglobulinemia / Q000097:blood / Q000175:diagnosis / Q000276:immunology*; D000368:Aged; D001706:Biopsy; D001856:Bone Marrow Examination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010257:Paraneoplastic Syndromes / Q000097:blood / Q000175:diagnosis / Q000276:immunology*; D012010:Red-Cell Aplasia, Pure / Q000097:blood / Q000175:diagnosis / Q000276:immunology*; D013934:Thymectomy; D013945:Thymoma / Q000097:blood / Q000175:diagnosis / Q000276:immunology* / Q000601:surgery; D013953:Thymus Neoplasms / Q000097:blood / Q000175:diagnosis / Q000276:immunology* / Q000601:surgery; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome