title: Miniature inhalation therapy platform using surface acoustic wave microfluidic atomization.
abstract: Pulmonary drug administration requires direct delivery of drug formulations into the lower pulmonary tract and alveoli of the lung in the form of inhaled particles or droplets, providing a distinct advantage over other methods for the treatment of respiratory diseases: the drug can be delivered directly to the site of inflammation, thus reducing the need for systemic exposure and the possibility of adverse effects. However, it is difficult to produce droplets of a drug solution within a narrow monodisperse size range (1-10 microm) needed for deposition in the lower pulmonary tract and alveoli. Here, we demonstrate the use of surface acoustic wave microfluidic atomization as an efficient means to generate appropriate aerosols containing a model drug, the short-acting beta2 agonist salbutamol, for the treatment of asthma. The mean aerosol diameter produced, 2.84+/-0.14 microm, lies well within the optimum size range, confirmed by a twin-stage impinger lung model, demonstrating that approximately 70 to 80% of the drug supplied to the atomizer is deposited within the lung. Our preliminary study explores how to control the aerosol diameter and lung delivery efficiency through the surface tension, viscosity, and input power, and also indicates which factors are irrelevant-like the fluid density. Even over a modest power range of 1-1.5 W, SAW atomization provides a viable and efficient generic nebulization platform for the delivery of drugs via the pulmonary route for the treatment of various diseases. The control offered over the aerosol size, low power requirements, high delivery efficiency, and the miniaturization of the system together suggest the proposed platform represents an attractive alternative to current nebulizers compatible with microfluidic technologies.
authors.affiliation: Micro/Nanophysics Research Laboratory, Department of Chemistry, Monash University, Clayton, VIC 3800, Australia.
authors.forename: Aisha
authors.initials: A
authors.lastname: Qi
authors.forename: James R
authors.initials: JR
authors.lastname: Friend
authors.forename: Leslie Y
authors.initials: LY
authors.lastname: Yeo
authors.forename: David A V
authors.initials: DA
authors.lastname: Morton
authors.forename: Michelle P
authors.initials: MP
authors.lastname: McIntosh
authors.forename: Leone
authors.initials: L
authors.lastname: Spiccia
mesh_terms: D000280:Administration, Inhalation; D000336:Aerosols; D000420:Albuterol / Q000008:administration & dosage / Q000493:pharmacokinetics; D001993:Bronchodilator Agents / Q000008:administration & dosage / Q000493:pharmacokinetics; D016503:Drug Delivery Systems / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D006801:Humans; D008168:Lung / Q000378:metabolism; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation*; D008954:Models, Biological; D009330:Nebulizers and Vaporizers; D012138:Respiratory Therapy / Q000295:instrumentation* / Q000379:methods; D014018:Tissue Distribution
chemical_list: D000336:Aerosols; D001993:Bronchodilator Agents; D000420:Albuterol