title: Biomimetic potential of some methacrylate-based copolymers: a comparative study.
abstract: Preparation of new biocompatible materials for bone recovery has consistently gained interest in the last few decades. Special attention was given to polymers that contain negatively charged groups, such as phosphate, carboxyl, and sulfonic groups toward calcification. This present paper work demonstrates that other functional groups present also potential application in bone pathology. New copolymers of 2-hydroxyethyl methacrylate with diallyldimethylammonium chloride (DADMAC), glycidyl methacrylate (GlyMA), methacrylic acid (MAA), 2-methacryloyloxymethyl acetoacetate (MOEAA), 2-methacryloyloxyethyltriethylammonium chloride (MOETAC), and tetrahydrofurfuryl methacrylate (THFMA) were obtained. The copolymers were characterized by FTIR, swelling potential, and they were submitted to in vitro tests for calcification and cytotoxicity evaluation. GlyMA and MOETAC-containing copolymers show promising results for further in vivo mineralization tests, as a potential alternative to the classical bone grafts, in bone tissue engineering.
authors.affiliation: INSERM, U922, LHEA, Faculty of Medicine, University of Angers, 1 rue Haute de Reculée, Angers Cedex 49045, France. teodora.zecheru@yahoo.com
authors.forename: Teodora
authors.initials: T
authors.lastname: Zecheru
authors.forename: Robert
authors.initials: R
authors.lastname: Filmon
authors.forename: Edina
authors.initials: E
authors.lastname: Rusen
authors.forename: Bogdan
authors.initials: B
authors.lastname: Mărculescu
authors.forename: Amar
authors.initials: A
authors.lastname: Zerroukhi
authors.forename: Corneliu
authors.initials: C
authors.lastname: Cincu
authors.forename: Daniel
authors.initials: D
authors.lastname: Chappard
mesh_terms: D000090:Acetoacetates / Q000737:chemistry; D000498:Allyl Compounds / Q000737:chemistry; D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000737:chemistry; D040761:Biomimetic Materials / Q000627:therapeutic use; D002113:Calcification, Physiologic; D002118:Calcium / Q000737:chemistry; D002460:Cell Line; D002470:Cell Survival; D002794:Choline / Q000031:analogs & derivatives / Q000737:chemistry; D004852:Epoxy Compounds / Q000737:chemistry; D005347:Fibroblasts / Q000166:cytology; D008689:Methacrylates / Q000737:chemistry*; D051379:Mice; D010758:Phosphorus / Q000737:chemistry; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry; D000644:Quaternary Ammonium Compounds / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D023822:Tissue Engineering
chemical_list: C545433:2-methacryloyloxyethyltriethylammonium; C545432:2-methacryloyloxymethyl acetoacetate; D000090:Acetoacetates; D000498:Allyl Compounds; D001672:Biocompatible Materials; D004852:Epoxy Compounds; D008689:Methacrylates; D011108:Polymers; D000644:Quaternary Ammonium Compounds; C092890:tetrahydrofurfuryl methacrylate; C008384:methacrylic acid; D010758:Phosphorus; C005044:hydroxyethyl methacrylate; C508190:diallyldimethylammonium chloride; D002794:Choline; C007870:glycidyl methacrylate; D002118:Calcium