[Roles of Aurora-A in tumorigenesis and prognosis of breast cancer].
Aurora kinases play key roles in the transition of G2/M phase by regulating functions of centrosomes and microtubules. Overexpression of Aurora-A, a new oncogene, can induce centrosome amplification, aneuploidy and tumor formation. Aurora kinases are closely associated with breast cancer. In this article, we reviewed the mechanisms of Aurora kinases inducing tumorigenesis of breast cancer via interacting with p53 gene, BRCA1 gene, PTEN/PI3K/AKT pathway, gene polymorphism, estrogen, and so on, analyzed the expression of Aurora kinases in breast cancer and its relationship with prognosis.
Xia
Liang-Ping
LP
State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, 510060, P.R. China. xialiangping@163.com
Zhou
Fei-Fei
FF
Yang
Ming-Tian
MT
Liu
Qiang
Q
D000818:Animals; D064127:Aurora Kinases; D001943:Breast Neoplasms / Q000209:etiology / Q000235:genetics / Q000378:metabolism*; D002278:Carcinoma in Situ / Q000209:etiology / Q000235:genetics / Q000378:metabolism; D018270:Carcinoma, Ductal, Breast / Q000209:etiology / Q000235:genetics / Q000378:metabolism*; D002471:Cell Transformation, Neoplastic; D004967:Estrogens / Q000378:metabolism; D005260:Female; D006801:Humans; D051059:PTEN Phosphohydrolase / Q000378:metabolism; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D011110:Polymorphism, Genetic; D011379:Prognosis; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D015398:Signal Transduction; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
D064127:Aurora Kinases; D004967:Estrogens; D051059:PTEN Phosphohydrolase; D019869:Phosphatidylinositol 3-Kinases; D017346:Protein Serine-Threonine Kinases; D051057:Proto-Oncogene Proteins c-akt; D016159:Tumor Suppressor Protein p53; C494929:PTEN protein, human