title: Efficient translational rehabilitation randomised controlled trial designs using disease progress modelling and trial simulation.
abstract: Given the challenges inherent in randomised trials of rehabilitation interventions, methods are required to increase trial efficiency and information yield. This paper discusses, in a non-technical manner, a class of statistical models that is particularly suited to the task of detecting potential treatment effects against a background of spontaneous change.
authors.affiliation: Institute of Neuroscience, Newcastle University, UK. r.j.forsyth@newcastle.ac.uk
authors.forename: Rob
authors.initials: R
authors.lastname: Forsyth
mesh_terms: D001930:Brain Injuries / Q000534:rehabilitation*; D003198:Computer Simulation; D018450:Disease Progression; D006801:Humans; D015233:Models, Statistical; D017711:Nonlinear Dynamics; D016032:Randomized Controlled Trials as Topic / Q000379:methods*; D012046:Rehabilitation / Q000379:methods*; D012107:Research Design; D057170:Translational Research, Biomedical / Q000379:methods*