title: HLA-matched allo-SCT after reduced intensity conditioning with fludarabine/CY in patients with metastatic breast cancer.
abstract: Fifteen patients with chemosensitive metastatic breast cancer (MBC) underwent reduced intensity (RIST) allo-SCT between 1999 and 2006. The purpose of this single-center study was to evaluate the feasibility, safety and efficacy of this therapeutic approach. The pretransplant conditioning regimen consisted of fludarabine (25 mg/m(2) at days -5 to -1) and CY (60 mg/kg at days -2, -1). Stem cells were from HLA-matched sibling donors. The treatment-related mortality was 2/15 (13%). Median PFS and OS were 144 days (43-509 days) and 303 days (122-1376 days), respectively. The 1-year PFS was 20%, and the 1-year and 2-year OS was 40 and 20%, respectively. No objective tumor responses were observed, but the relatively long PFS does suggest a graft-vs-tumor effect. Although RIST using this CY/fludarabine regimen is feasible, the efficacy in this set of patients was limited. Future clinical trials should be performed to improve the knowledge of mechanisms of antitumor effects in breast cancer.
authors.affiliation: Division of Hematology, Department of Internal Medicine, University Hospital Maastricht, Maastricht, The Netherlands.
authors.forename: A J H M
authors.initials: AJ
authors.lastname: Fleskens
authors.forename: R I
authors.initials: RI
authors.lastname: Lalisang
authors.forename: G M J
authors.initials: GM
authors.lastname: Bos
authors.forename: M
authors.initials: M
authors.lastname: van Gelder
authors.forename: R L H
authors.initials: RL
authors.lastname: Jansen
authors.forename: H C
authors.initials: HC
authors.lastname: Schouten
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000188:drug therapy / Q000276:immunology / Q000556:secondary / Q000628:therapy*; D003520:Cyclophosphamide / Q000627:therapeutic use; D018572:Disease-Free Survival; D005260:Female; D020350:Graft vs Tumor Effect; D018380:Hematopoietic Stem Cell Transplantation; D006650:Histocompatibility Testing; D006801:Humans; D008875:Middle Aged; D019653:Myeloablative Agonists; D019172:Transplantation Conditioning / Q000379:methods*; D014184:Transplantation, Homologous; D014740:Vidarabine / Q000031:analogs & derivatives / Q000627:therapeutic use
chemical_list: D019653:Myeloablative Agonists; D003520:Cyclophosphamide; D014740:Vidarabine; C024352:fludarabine