Serum or bile affects the in vitro azole susceptibilities of Candida spp.
Drug susceptibility tests were performed with a series of Candida spp. in media supplemented with serum or bile. The azole susceptibilities of several medically important Candida spp., including C. albicans but not C. parapsilosis, were significantly reduced in supplemented media. These findings have important implications for the mechanisms of acquired azole resistance in pathogenic fungi.
Nagi
Minoru
M
Department of Chemotherapy and Mycoses, National Institute of Infectious Diseases, Shinjuku-ku, Tokyo, Japan.
Tanabe
Koichi
K
Takano
Yukie
Y
Kikuchi
Ken
K
Miyazaki
Yoshitsugu
Y
Niimi
Masakazu
M
D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D001393:Azoles / Q000494:pharmacology*; D001646:Bile / Q000378:metabolism*; D002176:Candida albicans / Q000187:drug effects*; D004336:Drug Antagonism; D006801:Humans; D008826:Microbial Sensitivity Tests
D000935:Antifungal Agents; D001393:Azoles