title: One-pot synthesis of 4,5-biphenyl-2-pyrimidinylguanidine derivatives.
abstract: A simple and straightforward methodology toward the synthesis of novel 4,5-biphenyl-2-pyrimidinylguanidine compounds has been developed by one-pot reaction of biguaninde or dimethyldiguanide with isoflavones. A series of 20 new compounds was reported. All of them were characterized by FT-IR, NMR, and elemental analysis. A typical compound was determined by X-ray diffraction. A variety of substrates can participate in the process with good yields and high purities, making this methodology suitable for library synthesis in drug discovery.
authors.affiliation: Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, and School of Chemistry and Materials Science, Shaanxi Normal University, Xi'an 710062, PR China. zhangzt@snnu.edu.cn
authors.forename: Zun-Ting
authors.initials: ZT
authors.lastname: Zhang
authors.forename: Fei-Fei
authors.initials: FF
authors.lastname: Xu
authors.forename: Mi-Xiang
authors.initials: MX
authors.lastname: Gao
authors.forename: Li
authors.initials: L
authors.lastname: Qiu
mesh_terms: D006146:Guanidines / Q000138:chemical synthesis* / Q000737:chemistry; D007529:Isoflavones / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009287:Naphthyridines / Q000138:chemical synthesis*; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
chemical_list: D006146:Guanidines; D007529:Isoflavones; D009287:Naphthyridines; C545233:pyrimido(4,5-b)(1,6)naphthyridine