title: Skin barrier breakdown: a renaissance in emollient therapy.
abstract: Breakdown of the skin barrier is the first event in the development of atopic eczema (atopic dermatitis). Research over the past five years has indicated that this arises as a result of the interaction of environmental agents such as soap and other detergents with the products of changes in several genes. These genetic changes predispose to the breakdown of the skin barrier, which allows the penetration of allergens, triggering a flare of atopic eczema. This new understanding of how breakdown of the skin barrier is the first event in the development of atopic eczema provides a rationale for a renaissance in the use of a complete emollient therapy regimen in atopic eczema and related skin barrier breakdown diseases, such as asteatotic eczema and irritant contact dermatitis.
authors.affiliation: Sheffield Children's Hospital and Sheffield Teaching Hospitals, and School of Medicine and Biomedical Sciences, The University of Sheffield, Sheffield.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Cork
authors.forename: Simon
authors.initials: S
authors.lastname: Danby
mesh_terms: D003876:Dermatitis, Atopic / Q000503:physiopathology / Q000628:therapy*; D004643:Emollients / Q000627:therapeutic use*; D006801:Humans; D010353:Patient Education as Topic; D017592:Skin Care
chemical_list: D004643:Emollients