title: Synthesis and antibacterial activities of new metronidazole and imidazole derivatives.
abstract: New imidazole ring derivatives comprising 1,3-oxazoline, Schiff's bases, thiadiazole, oxadiazole and 1,2,4-triazole moieties are reported. 3-Aminobiimidazol-4-one compounds 7a-c were synthesized by the reaction of compounds 6a-c with hydrazine hydrate. Biimidazole esters 9a-c were converted into biimidazole hydrazide esters 10a-c. Compounds 7a-c and 10a-c were converted into a variety of derivatives.
authors.affiliation: Department of Chemistry, College of Sciences, The University of Mustansiriayah, Iraq. chemabdu@yahoo.com
authors.forename: Abdul Jabar Kh
authors.initials: AJ
authors.lastname: Atia
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008795:Metronidazole / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D011513:Proteus mirabilis / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D007093:Imidazoles; D008795:Metronidazole