Axonal sensory motor neuropathy in copper-deficient Wilson's disease.
Copper deficiency may cause myeloneuropathy or progressive limb weakness. By contrast, Wilson's disease (WD) is characterized by progressive copper accumulation with hepatic and neurological impairment and requires life-long treatment with zinc and/or chelator agents. We report a WD patient who developed axonal sensory motor neuropathy in the context of copper deficiency due to his treatment with zinc and chelators. Exhaustive testing for other etiologies was negative. After treatment adjustment, only mild clinical improvement was noted during long-term follow-up. Muscle Nerve 40: 294-296, 2009.
Foubert-Samier
Alexandra
A
Department of Neurology, University Hospital Bordeaux, Haut-Lévêque, Avenue Magellan, 33604 Pessac Cedex, France.
Kazadi
Annabelle
A
Rouanet
Marie
M
Vital
Anne
A
Lagueny
Alain
A
Tison
François
F
Meissner
Wassilios
W
D000328:Adult; D001369:Axons / Q000502:physiology; D002614:Chelating Agents / Q000009:adverse effects; D003300:Copper / Q000172:deficiency*; D006527:Hepatolenticular Degeneration / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D008297:Male; D009431:Neural Conduction / Q000502:physiology; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology*; D015032:Zinc / Q000009:adverse effects
D002614:Chelating Agents; D003300:Copper; D015032:Zinc