Primary cutaneous anaplastic large-cell lymphoma presenting with hemophagocytic syndrome: a case report and review of the literature.
Primary cutaneous anaplastic large-cell lymphoma (C-ALCL) is a rare entity of lymphoma. We report a case of C-ALCL presenting with hemophagocytic syndrome and skin lesion with giant ulcer. Histopathological examination of the skin biopsy specimens showed non-epidermotropic infiltrates with cohesive sheets of large tumor cells. The tumor cells showed CD4-, CD8+, CD30+, CD56-, ALK-, TIA-1+, and granzyme B+. C-ALCL is generally a disorder that progresses slowly and has a good prognosis. Manifestation of a giant ulcer and hemophagocytic syndrome, such as in the present case, is rare.
Shimizu
Yoko
Y
Department of Hematology, Comprehensive Cancer Center, International Medical Center, Saitama Medical University, 1397-1 Yamane, Hidaka, Saitama 350-1298, Japan.
Tanae
Ken
K
Takahashi
Naoki
N
Kohri
Mika
M
Arai
Eiichi
E
Bessho
Masami
M
Niitsu
Nozomi
N
D000328:Adult; D018572:Disease-Free Survival; D006801:Humans; D007150:Immunohistochemistry; D051359:Lymphohistiocytosis, Hemophagocytic / Q000209:etiology* / Q000532:radiotherapy; D017728:Lymphoma, Large-Cell, Anaplastic / Q000150:complications* / Q000532:radiotherapy; D008297:Male; D009361:Neoplasm Invasiveness; D012878:Skin Neoplasms / Q000209:etiology / Q000473:pathology; D012883:Skin Ulcer / Q000209:etiology*