WT1 expression at diagnosis does not predict survival in pediatric AML: a report from the Children's Oncology Group.
WT1 is a transcription factor that is aberrantly overexpressed in acute and chronic leukemias. Overexpression of WT1 in pediatric acute myeloid leukemia has been reported, but the prognostic significance is unclear because sample sizes in these studies have been relatively small. WT1 expression was measured by quantitative RT-PCR in samples obtained at diagnosis from 155 pediatric AML patients treated on a cooperative group protocol. Neither overall survival nor event-free survival was correlated with WT1 expression.
Noronha
Suzie A
SA
Division of Pediatric Oncology, Department of Oncology, The Johns Hopkins Hospital, Baltimore, Maryland 21231, USA.
Farrar
Jason E
JE
Alonzo
Todd A
TA
Gerbing
Robert B
RB
Lacayo
Norman J
NJ
Dahl
Gary V
GV
Ravindranath
Yaddanapudi
Y
Arceci
Robert J
RJ
Loeb
David M
DM
D002648:Child; D018572:Disease-Free Survival; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis* / Q000453:epidemiology / Q000401:mortality; D011379:Prognosis; D012333:RNA, Messenger / Q000032:analysis; D020133:Reverse Transcriptase Polymerase Chain Reaction; D015996:Survival Rate; D025721:WT1 Proteins / Q000235:genetics*
D012333:RNA, Messenger; D025721:WT1 Proteins