Murine interferon-gamma inducible protein-10 (IP-10) secreted by Lactococcus lactis chemo-attracts human CD3+ lymphocytes.
Chemokines are members of the super family of cytokines necessary for leukocyte recruitment in tissues and lymphoid organs. The interferon-gamma inducible protein-10 (IP-10) chemo-attracts CXCR3-expressing cells, such as activated T lymphocytes and monocytes. We have genetically engineered a strain of Lactococcus lactis to secrete a biologically active murine IP-10 that interacts with human CXCR3, its homolog receptor, and chemo-attracts human CD3+ T lymphocytes.
Villatoro-Hernandez
Julio
J
Departamento de Histología, Universidad Autónoma de Nuevo León, Madero y Aguirre Pequeño s/n, 64460, Monterrey, NL, Mexico.
Arce-Mendoza
Alma Yolanda
AY
Rosas-Taraco
Adrian G
AG
Esparza-González
Sandra Cecilia
SC
Guzmán-López
Santos
S
Elizondo-Omaña
Rodrigo E
RE
Chávez-Reyes
Arturo
A
Saucedo-Cárdenas
Odila
O
de Oca Luna
Roberto Montes
RM
D000595:Amino Acid Sequence; D000818:Animals; D017252:CD3 Complex / Q000378:metabolism*; D002630:Chemotactic Factors / Q000494:pharmacology*; D002633:Chemotaxis / Q000187:drug effects; D006801:Humans; D013294:Lactococcus lactis / Q000378:metabolism*; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects*; D051379:Mice; D008969:Molecular Sequence Data; D018121:Receptors, Cytokine / Q000737:chemistry / Q000378:metabolism*; D016415:Sequence Alignment
D017252:CD3 Complex; D002630:Chemotactic Factors; C104577:IP10-Mig receptor; D018121:Receptors, Cytokine