title: Evolution of the GST omega gene family in 12 Drosophila species.
abstract: Gene families provide a unique system to study the evolutionary relationships between related genes both within and between organisms. We can ascertain whether members of a gene family in different species are orthologs or paralogs. We may also search for evidence that may explain why duplicate genes are present. The availability of genome sequences for 12 Drosophila species allows us to address these questions with respect to the evolution of one gene family, the glutathione S transferase (GST) omega class. This gene family is of particular interest because of its relationship with human disease and its presence in a wide range of species.
authors.affiliation: Department of Biological Sciences, The George Washington University, Washington, DC 20052, USA.
authors.forename: Kathryn B
authors.initials: KB
authors.lastname: Walters
authors.forename: Paaqua
authors.initials: P
authors.lastname: Grant
authors.forename: Diana L E
authors.initials: DL
authors.lastname: Johnson
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001499:Bayes Theorem; D016000:Cluster Analysis; D019295:Computational Biology; D004330:Drosophila / Q000235:genetics* / Q000378:metabolism; D019143:Evolution, Molecular; D020869:Gene Expression Profiling; D005982:Glutathione Transferase / Q000235:genetics* / Q000378:metabolism; D008957:Models, Genetic; D008969:Molecular Sequence Data; D005810:Multigene Family / Q000235:genetics*; D010802:Phylogeny; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012641:Selection, Genetic; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D013045:Species Specificity
chemical_list: D005982:Glutathione Transferase