Neuroimmune aspects of the pathogenesis of Tourette's syndrome and experience in the use of immunoglobulins in children.
A total of 60 patients aged 6-16 years with tics and Tourette's syndrome were studied. Antibodies to caudate nucleus proteins were assayed by western blot hybridization. Ten patients with Tourette's syndrome were found to have antibodies to caudate nucleus protein. Seven patients with neuroleptic-resistant types of Tourette's syndrome received single transfusions of immunoglobulin preparations, which produced regression of vocal and motor hyperkinesias and improvement in behavior (remission for more than six months). The observation of antibodies to caudate nucleus proteins and the positive effects seen on administration of immunoglobulins to patients with Tourette's syndrome support previous data on the possibility of using immunoglobulin therapy in the treatment of tic-type hyperkinesias and provide evidence of the involvement of autoimmune mechanisms inducing damage to the dopaminergic system of the striatum.
Zykov
V P
VP
Department of Pediatric Neurology, Russian Postgraduate Medical Academy, Moscow, Russia.
Shcherbina
A Yu
AY
Novikova
E B
EB
Shvabrina
T V
TV
D000906:Antibodies / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005917:Globus Pallidus / Q000276:immunology*; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D008297:Male; D005879:Tourette Syndrome / Q000188:drug therapy* / Q000276:immunology*
D000906:Antibodies; D016756:Immunoglobulins, Intravenous