title: Different vascular response to concurrent implantation of sirolimus- and zotarolimus-eluting stents in the same vessel.
abstract: Drug-eluting stents (DES) have become routine therapy in clinical practice because restenosis is significantly reduced in patients treated with these devices. New generations of DES bearing newer antiproliferative drugs have been developed. Sirolimus was the first antiproliferative drug eluted by a DES (SES) while zotarolimus represents a sirolimus-derived, newer antiproliferative drug borne by a different kind of DES (ZES). This report describes two cases of different vascular response to concurrent side by side implantation of SES and ZES in the same vessel and highlights significant early restenosis of ZES as compared with SES.
authors.affiliation: Division of Cardiology, University of Naples Federico II, Via Sergio Pansini 5, Naples 80131, Italy.
authors.forename: Plinio
authors.initials: P
authors.lastname: Cirillo
authors.forename: Salvatore
authors.initials: S
authors.lastname: De Rosa
authors.forename: Vito
authors.initials: V
authors.lastname: Di Palma
authors.forename: Roberta
authors.initials: R
authors.lastname: De Rosa
authors.forename: Paola
authors.initials: P
authors.lastname: Maietta
authors.forename: Federico
authors.initials: F
authors.lastname: Piscione
authors.forename: Massimo
authors.initials: M
authors.lastname: Chiariello
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects* / Q000295:instrumentation*; D002317:Cardiovascular Agents / Q000008:administration & dosage*; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000628:therapy*; D023903:Coronary Restenosis / Q000000981:diagnostic imaging / Q000209:etiology* / Q000628:therapy; D004359:Drug Therapy, Combination; D054855:Drug-Eluting Stents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D011474:Prosthesis Design; D020123:Sirolimus / Q000008:administration & dosage / Q000031:analogs & derivatives*; D016896:Treatment Outcome
chemical_list: D002317:Cardiovascular Agents; D010975:Platelet Aggregation Inhibitors; C489443:zotarolimus; D020123:Sirolimus