Synthesis and evaluation of 4-acyl-2-thiazolylhydrazone derivatives for anti-Toxoplasma efficacy in vitro.
A new series of 4-acyl-2-thiazolylhydrazone derivatives was synthesized and screened for its in vitro activity against Toxoplasma gondii. We evaluated parasite growth inhibition and cytotoxicity, inhibition of replication, and inhibition of parasite invasion of host cells. The biological results indicated that some substances had an antiproliferative effect against intracellular T. gondii tachyzoites cultivated in vitro.
Chimenti
Franco
F
Dipartimento di Chimica e Tecnologie del Farmaco, Università La Sapienza, P.le A. Moro 5, 00185 Rome, Italy.
Bizzarri
Bruna
B
Bolasco
Adriana
A
Secci
Daniela
D
Chimenti
Paola
P
Carradori
Simone
S
Granese
Arianna
A
Rivanera
Daniela
D
Frishberg
Nathan
N
Bordón
Claudia
C
Jones-Brando
Lorraine
L
D000818:Animals; D000981:Antiprotozoal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D006835:Hydrazones / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014122:Toxoplasma / Q000187:drug effects* / Q000254:growth & development
D000981:Antiprotozoal Agents; D006835:Hydrazones