title: A randomized trial comparing sevoflurane and propofol in children undergoing MRI scans.
abstract: OBJECTIVE
  We compared three primary outcomes of pausing the magnetic resonance imaging (MRI) scan, emergence quality and respiratory complications.
  
  
  OBJECTIVE
  To measure and compare the quality between sevoflurane and propofol in children undergoing MRI scans.
  
  
  BACKGROUND
  No randomized controlled trial exists comparing the quality between sevoflurane and propofol for MRI.
  
  
  METHODS
  Two hundred unpremedicated children (18 months to 7 years) scheduled for brain MRI scans were recruited. After induction with sevoflurane, children were randomized to receive sevoflurane [general anesthesia with sevoflurane (GAS)] via laryngeal mask airway (LMA) or propofol [general anesthesia with propofol (GAP)] bolus and infusion for their scan. The three primary outcomes of pausing the MRI scan (P), agitation (A), and respiratory complications (R) were compared. Timeliness of care was also measured.
  
  
  RESULTS
  No MRI scan pauses were found in 92% and 80% in the GAS and GAP groups. The median and interquartile A scores were 3 (0, 7) in GAS and 0 (0, 4) in GAP groups respectively. There was no difference in respiratory complications between GAS and GAP (P = 0.62). The median and interquartile postanesthesia care unit (PACU) times were 25 (18, 34) for GAS and 31 (25, 44) for GAP (P = 0.0001). The median and interquartile total times were 78 (69, 90) for GAS and 88 (78, 100) for GAP (P = 0.0002).
  
  
  CONCLUSIONS
  Our study compared the three primary outcomes of pausing, agitation, and respiratory complications between the two groups, and we found no difference in respiratory complications. However, the GAP group had more pausing and less agitation than the GAS group.
authors.affiliation: Department of Anesthesiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1009, USA. ybryan@wfubmc.edu
authors.forename: Yvon F
authors.initials: YF
authors.lastname: Bryan
authors.forename: Lauren K
authors.initials: LK
authors.lastname: Hoke
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Taghon
authors.forename: Todd G
authors.initials: TG
authors.lastname: Nick
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
authors.forename: Stephanie M
authors.initials: SM
authors.lastname: Kennedy
authors.forename: James S
authors.initials: JS
authors.lastname: Furstein
authors.forename: Charles Dean
authors.initials: CD
authors.lastname: Kurth
mesh_terms: D000465:Algorithms; D000768:Anesthesia, General / Q000009:adverse effects; D000769:Anesthesia, Inhalation / Q000009:adverse effects; D000771:Anesthesia, Intravenous / Q000009:adverse effects; D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D001049:Apnea / Q000517:prevention & control; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007442:Intubation, Intratracheal; D008279:Magnetic Resonance Imaging; D008297:Male; D008738:Methyl Ethers; D009068:Movement; D015742:Propofol; D011595:Psychomotor Agitation / Q000517:prevention & control / Q000523:psychology; D011787:Quality of Health Care; D015656:Respiratory Mechanics / Q000187:drug effects; D000077149:Sevoflurane; D016896:Treatment Outcome
chemical_list: D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D008738:Methyl Ethers; D000077149:Sevoflurane; D015742:Propofol