title: Insights on nuclease mechanism: the role of proximal ammonium group on phosphate esters cleavage.
abstract: The role of remotely located ammonium groups in the active site of many phosphate-cleaving enzymes is investigated by using model systems thus providing mechanistic hints to a still unsolved problem.
authors.affiliation: Dipartimento di Scienze Chimiche and CNR-ITM, Universita di Padova, via Marzolo 1, I-35131 Padova, Italy.
authors.forename: Renato
authors.initials: R
authors.lastname: Bonomi
authors.forename: Giacomo
authors.initials: G
authors.lastname: Saielli
authors.forename: Umberto
authors.initials: U
authors.lastname: Tonellato
authors.forename: Paolo
authors.initials: P
authors.lastname: Scrimin
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Mancin
mesh_terms: D020134:Catalytic Domain; D004720:Endonucleases / Q000737:chemistry / Q000378:metabolism*; D008958:Models, Molecular; D010755:Organophosphates / Q000378:metabolism*; D000644:Quaternary Ammonium Compounds / Q000737:chemistry / Q000378:metabolism*
chemical_list: D010755:Organophosphates; D000644:Quaternary Ammonium Compounds; D004720:Endonucleases