title: [A comparison of three methods in establishing transplanted model of VX2 tongue carcinoma in rabbits].
abstract: OBJECTIVE
  To establish transplanted models of VX2 tongue carcinoma in rabbits by three methods and compare these models.
  
  
  METHODS
  After establishment of VX2 tumor-bearing rabbits, 72 New-Zealand white rabbits were randomly divided into 3 groups. Intact tumour tissue, modified tumour cell suspension, tumour cell suspension were respectively injected into the middle-third lateral border of the tongues of rabbits in 3 groups to induce transplanted VX2 tongue carcinoma. The histological features, the tumour-take rates and the metastasis rates of the 3 models were observed.
  
  
  RESULTS
  The tumour-take rate of 3 models were 83.3%, 91.7% and 33.3% respectively; the lymph node metastasis rates were 71.4%, 100.0% and 37.5% respectively; the lung metastasis rates were 35.7%, 81.3% and 0 respectively. The histological features of the transplanted VX2 tongue carcinoma of 3 models were all consistent with those of moderately differentiated carcinoma.
  
  
  CONCLUSIONS
  The biological properties of the transplanted VX2 tongue carcinoma of 3 models is much alike to tongue carcinoma in humans. The model established with modified tumor cell suspension is considered to be more suitable for tongue cancer study.
authors.affiliation: Dept. of Oral and Maxillofacial Surgery, Stomatological Hospital, Sun Yat-Sen University, Guangzhou 510055, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Tian
authors.forename: Gui-Qing
authors.initials: GQ
authors.lastname: Liao
authors.forename: Hai-Chao
authors.initials: HC
authors.lastname: Liu
authors.forename: Chuan-Zhen
authors.initials: CZ
authors.lastname: Li
authors.forename: Qing
authors.initials: Q
authors.lastname: Li
authors.forename: Jing-Xu
authors.initials: JX
authors.lastname: Wang
authors.forename: Ri-Chang
authors.initials: RC
authors.lastname: Du
authors.forename: Tong-Han
authors.initials: TH
authors.lastname: Zhang
mesh_terms: D000818:Animals; D002277:Carcinoma; D004195:Disease Models, Animal; D006801:Humans; D008207:Lymphatic Metastasis; D009368:Neoplasm Transplantation; D011817:Rabbits; D014062:Tongue Neoplasms