title: Sesquiterpene lactones from the root tubers of Lindera aggregata.
abstract: Phytochemical investigation of the root tubers of Lindera aggregata resulted in the isolation of five new sesquiterpene lactones, linderagalactones A-E (1-5), along with eight known sesquiterpenoids, 3-eudesmene-1beta,11-diol, hydroxylindestenolide, strychnistenolide, hydroxyisogermafurenolide, atractylenolide III, linderane, neolinderalactone, and linderalactone. The structures and relative configurations of 1-5 were determined by spectroscopic methods, especially HRESIMS and 2D NMR techniques. The absolute configurations of 1-4 were defined by comparison of quantum chemical TDDFT calculated and experimental ECD spectra. Linderagalactone A (1) is a halogenated sesquiterpene lactone possessing a unique rearranged carbon skeleton. Linderagalactone E (5), linderane, hydroxylindestenolide, and linderalactone showed hepatoprotective activity against H2O2-induced oxidative damages on HepG2 cells with EC(50) values of 67.5, 167.0, 42.4, and 98.0 microM, respectively.
authors.affiliation: Institute of Modern Chinese Medicine (IMCM), College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, People's Republic of China.
authors.forename: Li-She
authors.initials: LS
authors.lastname: Gan
authors.forename: Yun-Liang
authors.initials: YL
authors.lastname: Zheng
authors.forename: Jian-Xia
authors.initials: JX
authors.lastname: Mo
authors.forename: Xin
authors.initials: X
authors.lastname: Liu
authors.forename: Xin-Hua
authors.initials: XH
authors.lastname: Li
authors.forename: Chang-Xin
authors.initials: CX
authors.lastname: Zhou
mesh_terms: D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D027443:Lindera / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000975:Antioxidants; D004365:Drugs, Chinese Herbal; D007783:Lactones; D012717:Sesquiterpenes; C424802:atractylenolide III; C429208:strychnistenolide; C477965:linderalactone; D006861:Hydrogen Peroxide