[Determination of ion content and localization of vasopressin and aquaporin receptors in the gerbil kidney after the flight aboard biosatellite "Foton M3"].
After 12 days on space fight, body mass of gerbils decreased by 32.9%; however, the effective systems of regulation did not let changes in the concentration of Na, K, Mg ions in fresh samples of the renal cortex. These data are viewed as a reflection of the regulation systems strategy to preserve the optimal conditions for functioning of the kidney, a vital body organ. The cations were reduced significantly in the renal medulla when calculated for dry mass and compared with the synchronous control. This could have changed the osmoregulating function of the kidney during space fight and, due to small cations accumulation, caused the drop of the cortex/medulla osmotic gradient. Locations of V1a-, V1b- and V2-receptors and aquaporin 1 and 2 in renal tubule cells of gerbils before and fight are described.
Shakhmatova
E I
EI
Seliverstova
E V
EV
Natochin
Iu V
IuV
D000818:Animals; D051398:Aquaporin 1 / Q000378:metabolism*; D051399:Aquaporin 2 / Q000378:metabolism*; D005260:Female; D005849:Gerbillinae; D007672:Kidney Cortex / Q000378:metabolism*; D007679:Kidney Medulla / Q000378:metabolism*; D007684:Kidney Tubules / Q000378:metabolism*; D017483:Receptors, Vasopressin / Q000378:metabolism*; D013026:Space Flight; D018474:Weightlessness Simulation
D051399:Aquaporin 2; D017483:Receptors, Vasopressin; D051398:Aquaporin 1