Effect of smoking on activity of N-acetyl-beta-hexosaminidase in serum and urine of renal cancer patients.
OBJECTIVE
To compare N-acetyl-beta-hexosaminidase (HEX) activity in the serum and urine of smokers as well as non-smokers with renal cancer, and healthy people.


METHODS
To assess hexosaminidase activity the level of p-nitrophenol released from p-nitrophenol derivatives was measured.


RESULTS
The activity of enzyme was significantly higher in cancer group, with the highest activity in non-smokers.


CONCLUSIONS
Cigarette smoking can inhibit, by the influence on HEX activity, catabolism of oligosaccharide chains in cancer tissues.
Borzym-Kluczyk
Malgorzata
M
Department of Pharmaceutical Biochemistry, Medical University, Bialystok, Poland. gocha@umwb.edu.pl
Radziejewska
Iwona
I
Zaniewska
Agnieszka
A
Borzym-Lewszuk
Anna
A
Szajda
Sławomir Dariusz
SD
Knaś
Malgorzata
M
Zwierz
Krzysztof
K
Darewicz
Barbara
B
D014408:Biomarkers, Tumor / Q000097:blood / Q000652:urine; D006801:Humans; D007680:Kidney Neoplasms / Q000097:blood / Q000201:enzymology / Q000652:urine; D009596:Nitrophenols / Q000378:metabolism; D009844:Oligosaccharides / Q000378:metabolism; D012307:Risk Factors; D012907:Smoking / Q000097:blood / Q000652:urine; D001619:beta-N-Acetylhexosaminidases / Q000097:blood / Q000652:urine
D014408:Biomarkers, Tumor; D009596:Nitrophenols; D009844:Oligosaccharides; D001619:beta-N-Acetylhexosaminidases; C024836:4-nitrophenol