Cytotoxic action of triterpene glycosides from sea cucumbers from the genus Cucumaria on mouse spleen lymphocytes. Inhibition of nonspecific esterase.
Four triterpene glycosides from sea cucumbers belonging to the genus Cucumaria, okhotoside A(1)-1 (1), cucumarioside A(0)-1 (2), frondoside A (3) and cucumarioside A(2)-2 (4) inhibit the activity of nonspecific esterase of mouse spleen lymphocytes. The dependence of the inhibitory activity of the glycosides on their structure is similar to that for hemolytic activity. The absence of inhibitory activity for the preparation Cumaside, which is a complex of cucumarioside A(2)-2 and related compounds with cholesterol, shows a cholesterol-dependent character of the inhibitory action of the glycosides. The effective inhibitory concentrations of frondoside A and cucumarioside A(2)-2 are significantly higher than the immunomodulatory doses of these glycosides.
Aminin
Dmitry L
DL
Pacific Institute of Bioorganic Chemistry, Vladivostok, 690022, Russian Federation.
Silchenko
Alexandra S
AS
Avilov
Sergey A
SA
Stepanov
Vadim G
VG
Kalinin
Vladimir I
VI
D000818:Animals; D048016:Cucumaria / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry* / Q000633:toxicity*; D008214:Lymphocytes / Q000187:drug effects*; D051379:Mice; D008807:Mice, Inbred BALB C; D015394:Molecular Structure; D013154:Spleen / Q000166:cytology; D014315:Triterpenes / Q000737:chemistry* / Q000633:toxicity*
D006027:Glycosides; D014315:Triterpenes