Synthesis and evaluation of novel substituted 5-hydroxycoumarin and pyranocoumarin derivatives exhibiting significant antiproliferative activity against breast cancer cell lines.
A library of novel 5-hydroxycoumarin and pyranocoumarin derivatives was constructed via silica sulfuric acid-catalyzed pechmann reaction and Pd(0)-catalyzed suzuki coupling in tandem, and their antiproliferative activities against breast cancer cells MCF-7 and MDA-MB-231 were evaluated. The results showed that compounds such as 6b, 6d, 6h, and 6k possess significant antiproliferative activity against MCF-7 cell line with the IC(50) values of 7.2, 5.3, 3.3, and 6.5 microM, respectively.
Mao
Wei-wei
WW
Institute of Functional Molecule, South China University of Technology, Guangzhou 510641, People's Republic of China.
Wang
Ting-ting
TT
Zeng
He-ping
HP
Wang
Zhi-yu
ZY
Chen
Jian-ping
JP
Shen
Jian-gang
JG
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy*; D002384:Catalysis; D045744:Cell Line, Tumor; D003374:Coumarins / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D018360:Crystallography, X-Ray; D005260:Female; D006801:Humans; D008968:Molecular Conformation; D010165:Palladium / Q000737:chemistry; D039681:Pyranocoumarins / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D012822:Silicon Dioxide / Q000737:chemistry
D000970:Antineoplastic Agents; D003374:Coumarins; D039681:Pyranocoumarins; D010165:Palladium; D012822:Silicon Dioxide