title: Predictive value of the Disorders of Consciousness Scale (DOCS).
abstract: OBJECTIVE
  To examine the predictive validity of measures of neurobehavioral change derived from the Disorders of Consciousness Scale (DOCS) for predicting return to consciousness 4, 8, and 12 months after severe brain injury (BI).
  
  
  METHODS
  Prospective observational predictive validity study
  
  
  METHODS
  Inpatient rehabilitation hospitals and postrehabilitation residence
  
  
  METHODS
  A total of 113 persons with a mean age of 38 +/- 17.8 years who were unconscious for >28 days consecutively after severe BI; 73% (83/113) with traumatic BI and 27% (30/113) with other BI.
  
  
  METHODS
  Baseline DOCS, DOCS average, change from baseline DOCS to subsequent DOCS (DOCS2, DOCS3, DOCS4, DOCS5, DOCS6), and injury type (traumatic BI vs. other BI) MAIN OUTCOME MEASURE: Time to consciousness at 4, 8, and 12 months after injury
  
  
  RESULTS
  When controlling for injury type, the DOCS average as well as DOCS change between the first and second DOCS (DOCS1-2), first and fifth DOCS (DOCS1-5) and first and last DOCS (DOCStotalchg) significantly (P < or = .05) contributed to predicting recovery and lack of recovery of consciousness at 4, 8, and/or 12 months after injury. DOCS1-5 manifested the most balanced accuracy in predictions, where predicting recovery of consciousness is accurate 87% of the time and predicting lack of recovery of consciousness is accurate 88% of the time.
  
  
  CONCLUSIONS
  For persons with prolonged disorders of consciousness, the findings indicate that evidence-based prognostication for individual patients is possible. The implications for research are that the DOCS can be used as a meaningful, reliable, and valid primary outcome to measure treatment effects in clinical trials. The evidence indicates further that DOCS measures merit inclusion in future research that aims to develop multivariate prognostication models.
authors.affiliation: Department of Veterans Affairs (VA), Research Service and the Center for Management of Complex Chronic Care Center of Excellence, Edward Hines Jr. VA Hospital, Research Service (151H), Hines, IL 60141, USA. Theresa.Pape@va.gov
authors.forename: Theresa Louise-Bender
authors.initials: TL
authors.lastname: Pape
authors.forename: Charlene
authors.initials: C
authors.lastname: Tang
authors.forename: Ann
authors.initials: A
authors.lastname: Guernon
authors.forename: Sandra
authors.initials: S
authors.lastname: Lundgren
authors.forename: Melanie
authors.initials: M
authors.lastname: Blahnik
authors.forename: Yongliang
authors.initials: Y
authors.lastname: Wei
authors.forename: Melanie
authors.initials: M
authors.lastname: Querubin
authors.forename: Felise
authors.initials: F
authors.lastname: Zollman
authors.forename: Ileana
authors.initials: I
authors.lastname: Soneru
mesh_terms: D000328:Adult; D001930:Brain Injuries / Q000150:complications / Q000523:psychology* / Q000534:rehabilitation; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D009483:Neuropsychological Tests; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D020127:Recovery of Function; D014474:Unconsciousness / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology*; D055815:Young Adult