Palladium-catalyzed sequential cyanation/n-addition/N-arylation in one-pot: efficient synthesis of luotonin A and its derivatives.
With the catalysis of palladium, a number of 2-bromo-N-(2-iodobenzyl)benzamides underwent sequential cyanation/N-addition/N-arylation leading to the efficient construction of isoindolo[1,2-b]quinazolin-10(12H)-ones in a two-stage, one-pot manner. This method also allowed the convenient synthesis of luotonin A and its derivatives.
Ju
Yi
Y
Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, PR China.
Liu
Feng
F
Li
Chaozhong
C
D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry; D011809:Quinones / Q000138:chemical synthesis* / Q000737:chemistry
D011758:Pyrroles; D011809:Quinones; C480761:luotonin A; D010165:Palladium