title: Monitoring of acute axonal injury in the swine spinal cord with EAE by diffusion tensor imaging.
abstract: OBJECTIVE
  To evaluate the ability of diffusion tensor imaging (DTI) to detect and monitor acute axonal injury in swine spinal cord with acute experimental allergic encephalomyelitis (EAE).
  
  
  METHODS
  Magnetic resonance imaging of the cervical spinal cord was performed in vivo at different time points through the onset and progression of EAE using a 3 Tesla clinical scanner. The DTI parameters were calculated in four separate regions of interest at the C2/C3 level. The quantitative DTI-pathology and DTI-clinical correlations were verified.
  
  
  RESULTS
  In the monophasic acute course of EAE onset and progression, axial diffusivity (AD) decrease correlates with acute axonal injury (r = -0.84; P < 0.001). By contrast, radial diffusivity does not change and no demyelination in histopathology was detected. Moreover, a clear correlation between clinical disease and axial diffusivity was found in two swine EAE models (r = -0.86; P < 0.001 and r = -0.92; P < 0.001).
  
  
  CONCLUSIONS
  AD corresponds with axonal injury in the absence of demyelination and may be a useful noninvasive tool to investigate the underlying pathogenic processes of multiple sclerosis and to monitor the effects of experimental treatments for axonal injury.
authors.affiliation: Department of Medical Imaging, The First Military Hospital OF PLA, LanZhou, GanShu, China.
authors.forename: Song
authors.initials: S
authors.lastname: Feng
authors.forename: Yin
authors.initials: Y
authors.lastname: Hong
authors.forename: Zhang
authors.initials: Z
authors.lastname: Zhou
authors.forename: Zhang
authors.initials: Z
authors.lastname: Jinsong
authors.forename: Dai
authors.initials: D
authors.lastname: Xiaofeng
authors.forename: Wang
authors.initials: W
authors.lastname: Zaizhong
authors.forename: Ge
authors.initials: G
authors.lastname: Yali
authors.forename: Liu
authors.initials: L
authors.lastname: Ying
authors.forename: Chang
authors.initials: C
authors.lastname: Yingjuan
authors.forename: Huan
authors.initials: H
authors.lastname: Yi
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001369:Axons / Q000473:pathology*; D002574:Cervical Vertebrae; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D018450:Disease Progression; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000473:pathology*; D005240:Feasibility Studies; D005260:Female; D007091:Image Processing, Computer-Assisted; D007124:Immunoenzyme Techniques; D013116:Spinal Cord / Q000473:pathology*; D013552:Swine