title: Identification of an antiamyloidogenic substance from mulberry leaves.
abstract: Fibrillar aggregates of amyloid beta-peptides are major constituents of the plaques found in the brains of patients with Alzheimer's disease, and have been implicated in the neurotoxicity of Alzheimer's. We previously reported that the methanol extract of mulberry leaves inhibits the formation of amyloid beta-peptide (1-42)-fibrils in vitro, and protects hippocampal neurons from amyloid beta-peptide (1-42)-induced cell death. In this study, we identified antiamyloidogenic substances, pheophorbide a, kaempferol -3-O-glucoside, and kaempferol -3-O-(6-malonyl) glucoside, from the methanol extract of mulberry leaves. We also compared the antiamyloidogenic activity of pheophorbide a with that of other porphyrin-related compounds.
authors.affiliation: Department of Applied Biology, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan.
authors.forename: Parinda
authors.initials: P
authors.lastname: Khaengkhan
authors.forename: Yuki
authors.initials: Y
authors.lastname: Nishikaze
authors.forename: Tetsuhiro
authors.initials: T
authors.lastname: Niidome
authors.forename: Kenji
authors.initials: K
authors.lastname: Kanaori
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Tajima
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Ichida
authors.forename: Shigeharu
authors.initials: S
authors.lastname: Harada
authors.forename: Hachiro
authors.initials: H
authors.lastname: Sugimoto
authors.forename: Kaeko
authors.initials: K
authors.lastname: Kamei
mesh_terms: D016229:Amyloid beta-Peptides / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism; D002734:Chlorophyll / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification; D002845:Chromatography; D002851:Chromatography, High Pressure Liquid; D005960:Glucosides / Q000737:chemistry* / Q000302:isolation & purification; D006801:Humans; D044949:Kaempferols / Q000737:chemistry* / Q000302:isolation & purification; D013058:Mass Spectrometry; D000432:Methanol / Q000737:chemistry; D009005:Monosaccharides / Q000737:chemistry* / Q000302:isolation & purification; D031625:Morus / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D010446:Peptide Fragments / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification; D018515:Plant Leaves / Q000737:chemistry*; D011166:Porphyrins / Q000737:chemistry; D055503:Protein Multimerization / Q000187:drug effects
chemical_list: D016229:Amyloid beta-Peptides; D005960:Glucosides; D044949:Kaempferols; D009005:Monosaccharides; D010446:Peptide Fragments; D010936:Plant Extracts; D011166:Porphyrins; C075222:amyloid beta-protein (1-42); C544651:kaempferol -3-O-(6-malonyl) glucoside; C511963:kaempferol-3-O-glucoside; D002734:Chlorophyll; C032623:pheophorbide a; D000432:Methanol