In vitro antiviral activity of V-073 against polioviruses.
V-073, an enterovirus capsid inhibitor, was evaluated for its spectrum of antipoliovirus activity. V-073 inhibited all 45 polioviruses tested in a virus-induced cytopathic effect protection assay, with 50% effective concentration (EC50) values ranging from 0.003 to 0.126 microM. Ninety percent of the polioviruses tested were inhibited at EC(50)s of < or = 0.076 microM (MIC90 = 32 ng/ml). V-073 is a promising antiviral candidate for the posteradication management of poliovirus incidents.
Oberste
M Steven
MS
Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Moore
Deborah
D
Anderson
Barbara
B
Pallansch
Mark A
MA
Pevear
Daniel C
DC
Collett
Marc S
MS
D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D017955:Poliovirus / Q000187:drug effects*
D000998:Antiviral Agents