title: C29 sterols with a cyclopropane ring at C-25 and 26 from the Vietnamese marine sponge Ianthella sp. and their anticancer properties.
abstract: Two new C(29) sterols with a cyclopropane ring at C-25 and C-26, petrosterol-3,6-dione (1) and 5alpha,6alpha-epoxy-petrosterol (2), along with petrosterol (3), were isolated from the Vietnamese marine sponge Ianthella sp. The structures of the new compounds were elucidated by comprehensive spectroscopic analyses. Compounds 1-3 showed cytotoxic activities on A549, HL-60, MCF-7, SK-OV-3, and U937 cancer cell lines with IC(50) in the range of 8.4-22.6 microM, whereas compounds 1-3 exhibited only weak cytotoxic activities on HT-29 cell. After HL-60 cells were treated with the compounds, several apoptosis events like chromatin condensation and the increase of the population of sub-G1 hypodiploid cells were observed. These data supported that the compounds might have potential for leukemia treatment.
authors.affiliation: College of Pharmacy, Chungnam National University, Daejeon 305-764, Republic of Korea.
authors.forename: Huu Tung
authors.initials: HT
authors.lastname: Nguyen
authors.forename: Van Minh
authors.initials: VM
authors.lastname: Chau
authors.forename: Thu Ha
authors.initials: TH
authors.lastname: Tran
authors.forename: Van Kiem
authors.initials: VK
authors.lastname: Phan
authors.forename: Thanh Huong
authors.initials: TH
authors.lastname: Hoang
authors.forename: Tien Dat
authors.initials: TD
authors.lastname: Nguyen
authors.forename: Xuan Nhiem
authors.initials: XN
authors.lastname: Nguyen
authors.forename: Bui Huu
authors.initials: BH
authors.lastname: Tai
authors.forename: Jae-Hee
authors.initials: JH
authors.lastname: Hyun
authors.forename: Hee-Kyoung
authors.initials: HK
authors.lastname: Kang
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Kim
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002460:Cell Line; D004354:Drug Screening Assays, Antitumor; D018922:HL-60 Cells; D006801:Humans; D011161:Porifera / Q000737:chemistry*; D013261:Sterols / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D014744:Vietnam
chemical_list: C543942:5alpha,6alpha-epoxy-petrosterol; D000970:Antineoplastic Agents; D013261:Sterols; C543940:petrosterol-3,6-dione; C026361:petrosterol