title: [Survival and prognostic analysis of 221 patients with advanced laryngeal squamous cell carcinoma treated by surgery].
abstract: OBJECTIVE
  The prognosis of advanced squamous cell carcinoma of the larynx is poor Prognostic factors of this disease vary in different studies. This study was to analyze the most important factors affecting the prognosis of the patients with advanced (stage III and IV) squamous cell carcinoma (SCC) of the larynx.
  
  
  METHODS
  Clinical data of 221 patients with advanced SCC of the larynx were retrospectively analyzed. Survival analysis was performed by the life table method; comparison among/between groups was performed using the log-rank test; and multivariate analysis was carried out using the Cox proportional hazard model.
  
  
  RESULTS
  The two- and five-year overall survival rates of the 221 patients were 76.9% and 51.1%; while the 2-and 5-year disease free survival rates were 60.0% and 43.0%. Patients in stage III had better prognosis than those in stage IV. Post-operative radiotherapy improved the survival rate in patients with positive surgical margins. There was no difference in the survival rate between patients underwent partial laryngectomy and those underwent total laryngectomy. Multivariate analyses indicated that age, anatomic type, post-surgical stage, surgical margin and radiotherapy influenced the disease free survival (p<0.05), whereas, age, post-surgical stage and surgical margin affected the overall survival (p<0.05).
  
  
  CONCLUSIONS
  The prognosis of patients with advanced SCC of the larynx receiving surgery is poor. Age, post-surgical stage and surgical margin are the most important factors affecting the overall survival.
authors.affiliation: Key Laboratory of Oncology in South China, Guangzhou, Guangdong, P. R. China.
authors.forename: Tian-Run
authors.initials: TR
authors.lastname: Liu
authors.forename: An-Kui
authors.initials: AK
authors.lastname: Yang
authors.forename: Fu-Jin
authors.initials: FJ
authors.lastname: Chen
authors.forename: Mu-Sheng
authors.initials: MS
authors.lastname: Zeng
authors.forename: Ming
authors.initials: M
authors.lastname: Song
authors.forename: Zhu-Ming
authors.initials: ZM
authors.lastname: Guo
authors.forename: Wen-Kuan
authors.initials: WK
authors.lastname: Chen
authors.forename: Dian
authors.initials: D
authors.lastname: Ouyang
authors.forename: Qiu-Li
authors.initials: QL
authors.lastname: Li
authors.forename: Yan-Feng
authors.initials: YF
authors.lastname: Chen
authors.forename: Quan
authors.initials: Q
authors.lastname: Zhang
authors.forename: Zong-Yuan
authors.initials: ZY
authors.lastname: Zeng
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007822:Laryngeal Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D007825:Laryngectomy / Q000379:methods*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D037981:Neck Dissection; D009367:Neoplasm Staging; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D015996:Survival Rate