title: Synthesis of tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate.
abstract: Two efficient and scaleable synthetic routes to previously unknown bifunctional tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate are described. This compound and related intermediates described herein are useful for further selective derivation on the azetidine and cyclobutane rings providing a convenient entry point to novel compounds accessing chemical space complementary to piperidine ring systems.
authors.affiliation: Pfizer Global Research & Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017, USA. marVin.j.meyers@pfizer.com
authors.forename: Marvin J
authors.initials: MJ
authors.lastname: Meyers
authors.forename: Inouk
authors.initials: I
authors.lastname: Muizebelt
authors.forename: Jim
authors.initials: J
authors.lastname: van Wiltenburg
authors.forename: David L
authors.initials: DL
authors.lastname: Brown
authors.forename: Atli
authors.initials: A
authors.lastname: Thorarensen
mesh_terms: D001372:Aza Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D010880:Piperidines / Q000737:chemistry*; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D001372:Aza Compounds; D010880:Piperidines; D013141:Spiro Compounds; C544253:tert-butyl 6-oxo-2-azaspiro(3.3)heptane-2-carboxylate; C032727:piperidine