Metabolic syndrome defined by IDF and AHA/NHLBI correlates better to carotid intima-media thickness than that defined by NCEP ATP III and WHO.
OBJECTIVE
We conducted this study to compare the relationships between subclinical atherosclerosis and metabolic syndrome (MS) defined by four definitions in Chinese subjects.


METHODS
In 2006-2007, we enrolled 140 Chinese subjects without reported diabetes in this study. Anthropometric, biochemical profile, and carotid intima-media thickness (IMT) were measured. MS was defined by International Diabetes Federation (IDF), American Heart Association and the National Heart, Lung, and Blood Institute (AHA/NHLBI), National Cholesterol Education Program Adult Treatment Panal III (NCEP-ATP III), and World Health Organization (WHO) criteria.


RESULTS
Subjects with MS defined by IDF and AHA/NHLBI criteria had significantly higher carotid IMT, controlling for age, gender, smoking, and serum LDL-C (MS by IDF, partial r=0.225, p=0.008; AHA/NHLBI, partial r=0.176, p=0.04). The association between carotid IMT and MS defined by NCEP-ATP III or WHO criteria was not significant. Subjects with more components of MS defined by IDF, AHA/NHLBI, or NCEP-ATP III criteria correlated to higher carotid IMT in adjusted models (p-values for trend, MS by IDF, 0.011; AHA/NHLBI, 0.011; NCEP-ATPIII, 0.01; WHO, 0.113).


CONCLUSIONS
MS definitions by IDF and AHA/NHLBI criteria are the best among four definitions in detecting subclinical atherosclerosis in non-diabetic Chinese subjects; whereas MS defined by WHO criteria is the worst.
Ma
Wen-Ya
WY
Division of Endocrinology, Department of Internal Medicine, Cardinal Tien Hospital, Xindian 231, Taiwan.
Li
Hung-Yuan
HY
Hung
Chi Sheng
CS
Lin
Mao-Shin
MS
Chiu
Fu-Chun
FC
Lin
Cheng-Hsin
CH
Shih
Shyang-Rong
SR
Chuang
Lee-Ming
LM
Wei
Jung-Nan
JN
D000005:Abdomen / Q000033:anatomy & histology; D000328:Adult; D002339:Carotid Arteries / Q000473:pathology; D008076:Cholesterol, HDL / Q000097:blood; D003920:Diabetes Mellitus / Q000175:diagnosis / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D054555:National Heart, Lung, and Blood Institute (U.S.); D009765:Obesity / Q000473:pathology; D012955:Societies, Medical; D014280:Triglycerides / Q000097:blood; D017539:Tunica Intima / Q000473:pathology; D017540:Tunica Media / Q000473:pathology; D014481:United States; D014944:World Health Organization
D008076:Cholesterol, HDL; D014280:Triglycerides