title: Fibroepithelial lesions of the breast with pleomorphic stromal giant cells: a clinicopathologic study of 4 cases and review of the literature.
abstract: Pleomorphic stromal giant cells are occasionally found as an incidental finding in breast tissue but are only rarely seen in fibroepithelial lesions. In this report, we describe 4 fibroadenoma-like lesions of the breast with pleomorphic stromal giant cells. Two cases had focal stromal hypercellularity, one of which was with architectural features borderline between a fibroadenoma and a phyllodes tumor, but none was considered diagnostic of phyllodes tumor. One lesion had up to 4 mitotic figures per 10 high-power fields, including rare atypical mitotic figures. The remaining 3 cases lacked mitotic activity. Follow-up for 3 cases at 16 to 59 months revealed no evidence of tumor recurrence. The fourth case was lost to follow-up. It appears that the presence of pleomorphic stromal giant cells in an otherwise benign fibroepithelial lesion has no adverse clinical significance. The clinicopathologic features of each case are discussed, and a review of the literature is provided.
authors.affiliation: Department of Pathology and Laboratory Medicine, The University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA. leihuo@mdanderson.org
authors.forename: Lei
authors.initials: L
authors.lastname: Huo
authors.forename: Michael Z
authors.initials: MZ
authors.lastname: Gilcrease
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000175:diagnosis / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D018226:Fibroadenoma / Q000175:diagnosis / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D008938:Mitosis; D018225:Neoplasms, Fibroepithelial / Q000175:diagnosis / Q000473:pathology*; D003557:Phyllodes Tumor / Q000175:diagnosis / Q000473:pathology; D017154:Stromal Cells / Q000473:pathology*