Flow injection titration basing on the merging-zone technique.
The proposed approach relies on titration of a sample that is gradually diluted in strictly controlled way in the flow injection system developed. On each step of sample dilution equal volumes of the sample and titrant solutions are simultaneously injected into two carrier streams and the zones are merged with each other. Then, they are mixed completely in the mixing chamber, merged with a stream of indicator and directed to a detector. It has been revealed that the method provides the results with accuracy better than +/-3.3% (RE) and with mean repeatability lower than 1.0% (RSD). When the analyte concentration in a sample is too low to be determined directly, the procedure of titration with standard addition is exploited. The proposed approach has been successfully applied to the determination of total acidity in vinegar and magnesium and calcium in pharmaceutical products. The results obtained were comparable with those provided by the reference methods. The proposed procedure is characterized by low consumption of sample (usually less than 2 mL), titrant (about 3 mL) and indicator (about 0.6 mL). Average time of a single analysis is similar to time of traditional batch analysis.
Wójtowicz
Marzena
M
Department of Analytical Chemistry, Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060 Kraków, Poland.
Kozak
Joanna
J
Danielewska
Karolina
K
Kościelniak
Paweł
P