Insights into angiogenic imbalances during pregnancy.
BACKGROUND
An excess of either angiogenic or antiangiogenic factors may participate in the pathophysiology of life-threatening pregnancy complications.


METHODS
We describe two patients with severe early onset preeclampsia associated with partial mole or sacrococcygeal teratoma who had an excess of circulating concentrations of the antiangiogenic factors soluble vascular endothelial growth factor receptor-1 and soluble endoglin. In contrast, a patient with severe ovarian hyperstimulation syndrome at 5 weeks of gestation had an excess of circulating free vascular endothelial growth factor, a key angiogenic factor.


CONCLUSIONS
Angiogenic imbalances may participate in the pathophysiology of early onset preeclampsia associated with partial mole or sacrococcygeal teratoma as well as in the pathophysiology of severe ovarian hyperstimulation syndrome during pregnancy.
Espinoza
Jimmy
J
From the Department of Obstetrics and Gynecology, William Beaumont Hospital, Royal Oak, Michigan.
Uckele
John E
JE
Starr
Robert A
RA
Lorenz
Robert P
RP
Bronsteen
Richard A
RA
Berry
Stanley M
SM
D000328:Adult; D042501:Angiogenic Proteins / Q000097:blood*; D015703:Antigens, CD / Q000097:blood; D000071063:Endoglin; D005260:Female; D006801:Humans; D006828:Hydatidiform Mole / Q000097:blood*; D016471:Ovarian Hyperstimulation Syndrome / Q000097:blood* / Q000209:etiology / Q000473:pathology; D011225:Pre-Eclampsia / Q000097:blood* / Q000209:etiology / Q000473:pathology; D011247:Pregnancy; D011956:Receptors, Cell Surface / Q000097:blood; D012445:Sacrococcygeal Region; D013724:Teratoma / Q000097:blood*; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000097:blood*
D042501:Angiogenic Proteins; D015703:Antigens, CD; C064206:ENG protein, human; D000071063:Endoglin; D011956:Receptors, Cell Surface; D040281:Vascular Endothelial Growth Factor Receptor-1