title: Foreign body granulomatous reactions to cosmetic fillers: a clinical study of 15 cases.
abstract: BACKGROUND
  Subcutaneous or submucosal infiltration of cosmetic materials is a very common practice, because of the ease with which such materials can be deposited, and their presumed innocuousness. However, in recent years there have been reports of foreign body granulomatous reactions occurring many years after infiltration.
  
  
  METHODS
  Data were collected on the clinical manifestations, histopathological findings, treatment, and course of the lesions of 15 patients.
  
  
  RESULTS
  One male and 14 females presented orofacial swelling an average of 7 years after the infiltration of silicone (n = 9), hyaluronic acid (n = 2), collagen (n = 2), methacrylate (n = 1), and polyalkylimide (n = 1). The patients were treated mainly with systemic corticosteroids, and were followed for an average of 17 months.
  
  
  CONCLUSIONS
  Systemic corticosteroids are able to control granulomatous reactions, which manifest in the form of outbreaks and tend to undergo spontaneous remission over the years.
authors.affiliation: Service of Stomatology, Valencia University General Hospital, Valencia University Medical and Dental School, Valencia, Spain. sanchisj@uv.es
authors.forename: Jose Maria
authors.initials: JM
authors.lastname: Sanchis-Bielsa
authors.forename: Jose Vicente
authors.initials: JV
authors.lastname: Bagán
authors.forename: Rafael
authors.initials: R
authors.lastname: Poveda
authors.forename: Inmaculada
authors.initials: I
authors.lastname: Salvador
mesh_terms: D000328:Adult; D000368:Aged; D001672:Biocompatible Materials / Q000009:adverse effects*; D003094:Collagen / Q000009:adverse effects; D003357:Cosmetic Techniques / Q000009:adverse effects*; D005260:Female; D015745:Granuloma, Foreign-Body / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D019736:Prostheses and Implants / Q000009:adverse effects*; D012828:Silicones / Q000009:adverse effects
chemical_list: D001672:Biocompatible Materials; D012828:Silicones; D003094:Collagen