title: NMR assignment and secondary structure of human growth arrest and DNA damage alpha protein (Gadd45 alpha).
abstract: Gadd45 alpha is a predominantly nuclear protein encoded by a DNA-damage-inducible gene which is transcriptionally regulated by the tumor suppressor p53. The interactions of Gadd45 alpha with several other proteins play a central role in DNA repair, cell cycle control and apoptosis. The NMR assignments of human Gadd45 alpha protein reported here provide the basis for further characterization of these interactions.
authors.affiliation: Structural Biology Unit, CIC Biogune, Parque Tecnológico de Bizkaia, Ed. 800, Derio, 48160, Spain.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Sánchez
authors.forename: David
authors.initials: D
authors.lastname: Pantoja-Uceda
authors.forename: Daniel
authors.initials: D
authors.lastname: Torres
authors.forename: Jesús
authors.initials: J
authors.lastname: Prieto
authors.forename: Ramón
authors.initials: R
authors.lastname: Campos-Olivas
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Blanco
mesh_terms: D000595:Amino Acid Sequence; D001665:Binding Sites; D002247:Carbon Isotopes / Q000737:chemistry; D018797:Cell Cycle Proteins / Q000737:chemistry* / Q000648:ultrastructure*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008969:Molecular Sequence Data; D008970:Molecular Weight; D009587:Nitrogen Isotopes / Q000737:chemistry; D009687:Nuclear Proteins / Q000737:chemistry* / Q000648:ultrastructure*; D011485:Protein Binding; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D011522:Protons; D000097642:GADD45 Proteins
chemical_list: D002247:Carbon Isotopes; D018797:Cell Cycle Proteins; D009587:Nitrogen Isotopes; D009687:Nuclear Proteins; D011522:Protons; C439070:GADD45A protein, human; D000097642:GADD45 Proteins