title: [Pulmonary carcinomatous lymphangiosis from recurrent breast cancer 10 years after resection of the primary tumor].
abstract: A 55-year-old woman had a history of left mastectomy due to early breast cancer in 1998. She had been suffering from dyspnea on effort and dry cough since August in 2007, and visited our hospital 6 months later because the symptoms had been becoming worse. She was hypoxic and her chest radiograph showed bilateral diffuse shadows, so she was hospitalized. The specimen of transbronchial lung biopsy showed undifferentiated adenocarcinoma cells in lymphatics identified by lymphatic endothelium antibody D2-40 stain, so we diagnosed carcinomatous lymphangiosis. It also revealed the cells staining positive for Cytokeratin 7, negative for Cytokeratin 20, and positive for both estrogen receptor and progesterone receptor. These features were identical to the immunohistological findings of the specimen from the previously resected breast cancer. Chemotherapy with docetaxel was effective and improved her respiratory condition and the chest radiograph. The immunohistological findings are useful for diagnosis and selection of cancer therapy. We cannot find any case reports of recurrence with carcinomatous lymphangiosis over 10 years after resection of breast cancer in Japan. We must keep in mind that some cancers relapse after a long disease-free interval.
authors.affiliation: Department of Respiratory Medicine, National Hospital Organization Okayama Medical Center.
authors.forename: Michiko
authors.initials: M
authors.lastname: Asano
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Matsuo
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Ueda
authors.forename: Mizuho
authors.initials: M
authors.lastname: Tsushima
authors.forename: Makoto
authors.initials: M
authors.lastname: Mizuta
authors.forename: Keiichi
authors.initials: K
authors.lastname: Fujiwara
authors.forename: Toshiro
authors.initials: T
authors.lastname: Yonei
authors.forename: Toshio
authors.initials: T
authors.lastname: Sato
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology* / Q000556:secondary*; D001943:Breast Neoplasms / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary*; D008208:Lymphatic System / Q000473:pathology*; D008408:Mastectomy; D008875:Middle Aged; D013997:Time Factors