Synthesis and antitumor evaluation of 8-phenylaminopyrimido[4,5-c]isoquinolinequinones.
A series of 8-phenylaminopyrimido[4,5-c]isoquinoline-7,10-quinone derivatives were prepared by regioselective amination reaction of pyrimido[4,5-c]isoquinoline-7,10-quinones with arylamines in the presence of a Lewis acid catalyst. Preliminary evaluation of the members of the series against cancer cell lines and assays of activation of their cytotoxic activity on K562 cells with ascorbic acid are reported.
Vásquez
David
D
Facultad de Química, Pontificia Universidad Católica de Chile, Casilla 306, Santiago, Chile.
Rodríguez
Jaime A
JA
Theoduloz
Cristina
C
Verrax
Julien
J
Calderon
Pedro Buc
PB
Valderrama
Jaime A
JA
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D001205:Ascorbic Acid / Q000494:pharmacology; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D011809:Quinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity
D000970:Antineoplastic Agents; D011809:Quinones; D001205:Ascorbic Acid