Efficacy of albaconazole against Candida albicans in a vaginitis model.
The efficacy of albaconazole (ABC) was evaluated using a murine model of vaginal Candida albicans infection. Both ABC and fluconazole (FLC) were effective in reducing the fungal load from vaginas of infected mice; however, ABC demonstrated encouraging activities against an FLC-resistant strain, with trends toward superiority over FLC in some treatment groups.
González
Gloria M
GM
Departamento de Microbiología, Facultad de Medicina, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, México. gmglez@yahoo.com.mx
Robledo
Efrén
E
Garza-González
Elvira
E
Elizondo
Mariana
M
González
J Gerardo
JG
D000284:Administration, Oral; D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D002176:Candida albicans / Q000187:drug effects*; D005260:Female; D015725:Fluconazole / Q000494:pharmacology / Q000627:therapeutic use; D051379:Mice; D008807:Mice, Inbred BALB C; D011799:Quinazolines / Q000494:pharmacology* / Q000627:therapeutic use*; D014230:Triazoles / Q000494:pharmacology* / Q000627:therapeutic use*; D014627:Vaginitis / Q000188:drug therapy* / Q000382:microbiology
D000935:Antifungal Agents; D011799:Quinazolines; D014230:Triazoles; D015725:Fluconazole; C112424:albaconazole