New 2,6-bis-[uracil-imino] ethylpyridine complexes containing the CdN(6) core: Synthesis, crystal structures, luminescent properties and antiproliferative activity against C6 glioma cells.
Three new Cd(II) complexes with the Schiff base ligand derived from the condensation 1+2 of 2,6-diacetylpyridine and 5,6-diamino-1,3-dimethyluracil have been "in template" synthesized. The molecular structures of complexes were determined by single-crystal X-ray diffraction. The metal center shows a very distorted mer-bis-tridentate CdN(6) octahedral geometry as consequence of the reduced bite angles of the ligand and the existence of long-distanced interactions with donor atoms in the neighbourhood. The luminescent properties of complexes in CH(3)CN solution were investigated showing the emission energies depend on the uracil part of the ligand. The evaluation of their biological properties against C6 glioma cell line indicates that cadmium(II) complexes could be an interesting tools to treat drug-resistant brain tumors.
Illán-Cabeza
Nuria A
NA
Departamento de Química Inorgánica y Orgánica, Universidad de Jaén, Spain.
Jiménez-Pulido
Sonia B
SB
Martínez-Martos
José M
JM
Ramírez-Expósito
María J
MJ
Moreno-Carretero
Miguel N
MN
D000818:Animals; D019187:Cadmium Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D018360:Crystallography, X-Ray; D005910:Glioma / Q000473:pathology*; D006860:Hydrogen Bonding; D008958:Models, Molecular; D008968:Molecular Conformation; D017672:Nitrogen Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D009942:Organometallic Compounds / Q000737:chemistry*; D051381:Rats; D013050:Spectrometry, Fluorescence
D019187:Cadmium Compounds; D017672:Nitrogen Compounds; D009942:Organometallic Compounds