Oleanane-type triterpenoids from Aceriphyllum rossii and their cytotoxic activity.
The hexane-soluble fraction of the roots of Aceriphyllum rossii was used to isolate seven new oleanane-type triterpenoids, aceriphyllic acids C-I (1-7), together with seven known triterpenoids. The structures of aceriphyllic acids C-I were determined as 3alpha-hydroxyolean-12-en-23,29-dioic acid (1), 3beta-hydroxyolean-12-en-23,29-dioic acid (2), 3beta,23-dihydroxyolean-12-en-29-oic acid (3), 3alpha-O-acetylolean-12-en-23,27-dioic acid (4), 3alpha-O-caffeoylolean-12-en-27-oic acid (5), 3alpha-O-acetylolean-12-en-23,29-dioic acid (6), and 3alpha-hydroxyolean-12-en-23-al-27-oic acid (7) by spectroscopic analyses. In the evaluation of the in vitro cytotoxicity of these compounds against the MCF-7 and LLC cancer cell lines, compounds 10 and 13 exhibited cytotoxic activity against the LLC cancer cell line with IC(50) values of 7.63 and 6.56 microM, respectively.
Van
Le Thi Kim
le TK
College of Pharmacy, Catholic University of Daegu, Gyeongsan 712-702, Korea.
Hung
Tran Manh
TM
Thuong
Phuong Thien
PT
Ngoc
Tran Minh
TM
Kim
Jin Cheol
JC
Jang
Han-Su
HS
Cai
Xing Fu
XF
Oh
Sei Ryang
SR
Min
Byung-Sun
BS
Woo
Mi Hee
MH
Choi
Jae Sue
JS
Lee
Hyeong Kyu
HK
Bea
Kihwan
K
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007723:Korea; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009828:Oleanolic Acid / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D031995:Saxifragaceae / Q000737:chemistry*
D000972:Antineoplastic Agents, Phytogenic; D009828:Oleanolic Acid