title: Paracoccidioidomycosis: high-resolution computed tomography-pathologic correlation.
abstract: OBJECTIVE
  The purpose of this study was to describe the high-resolution computed tomography (HRCT) features of pulmonary paracoccidioidomycosis and to correlate them with pathologic findings.
  
  
  METHODS
  The study included 23 adult patients with pulmonary paracoccidioidomycosis. All patients had undergone HRCT, and the images were retrospectively analyzed by two chest radiologists, who reached decisions by consensus. An experienced lung pathologist reviewed all pathological specimens. The HRCT findings were correlated with histopathologic data.
  
  
  RESULTS
  The predominant HRCT findings included areas of ground-glass opacities, nodules, interlobular septal thickening, airspace consolidation, cavitation, and fibrosis. The main pathological features consisted of alveolar and interlobular septal inflammatory infiltration, granulomas, alveolar exudate, cavitation secondary to necrosis, and fibrosis.
  
  
  CONCLUSIONS
  Paracoccidioidomycosis can present different tomography patterns, which can involve both the interstitium and the airspace. These abnormalities can be pathologically correlated with inflammatory infiltration, granulomatous reaction, and fibrosis.
authors.affiliation: Fluminense Federal University, Rio de Janeiro, Brazil. edmarchiori@gmail.com
authors.forename: Edson
authors.initials: E
authors.lastname: Marchiori
authors.forename: Paulo Marcos
authors.initials: PM
authors.lastname: Valiante
authors.forename: Claudia Mauro
authors.initials: CM
authors.lastname: Mano
authors.forename: Gláucia
authors.initials: G
authors.lastname: Zanetti
authors.forename: Dante L
authors.initials: DL
authors.lastname: Escuissato
authors.forename: Arthur Soares
authors.initials: AS
authors.lastname: Souza
authors.forename: Domenico
authors.initials: D
authors.lastname: Capone
mesh_terms: D000328:Adult; D001706:Biopsy; D005260:Female; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology; D008172:Lung Diseases, Fungal / Q000000981:diagnostic imaging* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010229:Paracoccidioidomycosis / Q000000981:diagnostic imaging* / Q000473:pathology*; D011856:Radiographic Image Enhancement / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013223:Statistics as Topic; D014057:Tomography, X-Ray Computed / Q000379:methods*; D055815:Young Adult