The imbalance in serum concentration of Th-1- and Th-2-derived chemokines as one of the factors involved in pathogenesis of atopic dermatitis.
Atopic dermatitis (AD) is an inflammatory skin disease in which pathogenesis chemokines are partially involved. The aim of the paper was to assess the serum level of CXCL-9, CXCL-10, CXCL-11, CXCL-12, CCL-17, CCL-20, CCL-21, CCL-22, CCL-27, and IL-18 chosen in AD patients by ELISA assay. Forty patients (mean age 11.4 years old) with AD and 50 healthy controls were enrolled into the study. The patients and controls were divided into two age categories: under 10 years old (Group 1 and Control 1) and over 10 years old (Group 2 and Control 2). Significantly lower serum concentration of CXCL-9, CXCL-10, CCL-17, and IL-18 and higher concentration of CXCL-12 and CCL-27 were found in Group 1 when compared to Control 1. In Group 2 serum concentration of CXCL-12, CCL-17, CCL-22 was higher than in Control 2. The obtained results indicate the imbalance in chemokine serum levels in AD what suggests their role in the disease pathogenesis.
Narbutt
Joanna
J
Department of Dermatology, Medical University of Lodz, Lodz, Poland. joanna.narbutt@umed.lodz.pl
Lesiak
Aleksandra
A
Sysa-Jedrzeiowska
Anna
A
Zakrzewski
Marcin
M
Bogaczewicz
Jarosław
J
Stelmach
Iwona
I
Kuna
Piotr
P
D000293:Adolescent; D000367:Age Factors; D016022:Case-Control Studies; D054414:Chemokine CCL17 / Q000097:blood; D054418:Chemokine CCL20 / Q000097:blood; D054421:Chemokine CCL21 / Q000097:blood; D054422:Chemokine CCL22 / Q000097:blood; D054425:Chemokine CCL27 / Q000097:blood; D054357:Chemokine CXCL10 / Q000097:blood; D054371:Chemokine CXCL11 / Q000097:blood; D054377:Chemokine CXCL12 / Q000097:blood; D018925:Chemokines / Q000097:blood*; D002648:Child; D003876:Dermatitis, Atopic / Q000097:blood* / Q000503:physiopathology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D020382:Interleukin-18 / Q000097:blood; D008297:Male; D018417:Th1 Cells / Q000378:metabolism*; D018418:Th2 Cells / Q000378:metabolism*
C106230:CCL17 protein, human; C108355:CCL20 protein, human; C515478:CCL21 protein, human; C515482:CCL22 protein, human; C492276:CCL27 protein, human; C114753:CXCL10 protein, human; C515202:CXCL11 protein, human; C515255:CXCL12 protein, human; D054414:Chemokine CCL17; D054418:Chemokine CCL20; D054421:Chemokine CCL21; D054422:Chemokine CCL22; D054425:Chemokine CCL27; D054357:Chemokine CXCL10; D054371:Chemokine CXCL11; D054377:Chemokine CXCL12; D018925:Chemokines; D020382:Interleukin-18