title: Disturbed homeostasis of zinc and other essential elements  in the prostate gland dependent on the character  of pathological lesions.
abstract: Pathophysiological changes in the prostate take the form of benign prostate hyperplasia (BPH) and prostate adenocarcinoma (PCa). In prostate, zinc is particularly important to its normal functioning, especially in terms of the consequences of hormone disturbance. The aim of this study was to assess the levels of Zn, Cu, Ca, Mg, and Se in the prostate dependent on the character of patological changes. Zinc, copper, magnesium and calcium were determined by AAS and selenium with spectrofluorometric method. Zn levels in BPH patients were over twofold higher than in controls. On the other hand, in the patients with PCa, the levels of Zn were found almost three times lower than in BPH patients and by almost 50% lower than in controls. In this study, significant changes in the levels of other essential elements were observed. The results apparently confirm the disturbed homeostasis of zinc and other essential elements in the etiology of BPH and PCa.
authors.affiliation: Department of Toxicology, Faculty of Pharmacy, Medical University, Muszynskiego 1, 90-151 Lodz, Poland. asapota@pharm.am.lodz.pl
authors.forename: Andrzej
authors.initials: A
authors.lastname: Sapota
authors.forename: Adam
authors.initials: A
authors.lastname: Darago
authors.forename: Jan
authors.initials: J
authors.lastname: Taczalski
authors.forename: Anna
authors.initials: A
authors.lastname: Kilanowicz
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry* / Q000473:pathology; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D002118:Calcium / Q000032:analysis; D003300:Copper / Q000032:analysis; D015536:Down-Regulation; D006706:Homeostasis; D006801:Humans; D008274:Magnesium / Q000032:analysis; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000737:chemistry* / Q000473:pathology; D011470:Prostatic Hyperplasia / Q000378:metabolism* / Q000473:pathology; D011471:Prostatic Neoplasms / Q000737:chemistry* / Q000473:pathology; D012643:Selenium / Q000032:analysis; D013050:Spectrometry, Fluorescence; D013054:Spectrophotometry, Atomic; D015854:Up-Regulation; D015032:Zinc / Q000032:analysis*
chemical_list: D003300:Copper; D012643:Selenium; D008274:Magnesium; D015032:Zinc; D002118:Calcium