A high-performance nanobio photocatalyst for targeted brain cancer therapy.
We report pronounced and specific antiglioblastoma cell phototoxicity of 5 nm TiO(2) particles covalently tethered to an antibody via a dihydroxybenzene bivalent linker. The linker application enables absorption of a visible part of the solar spectrum by the nanobio hybrid. The phototoxicity is mediated by reactive oxygen species (ROS) that initiate programmed death of the cancer cell. Synchrotron X-ray fluorescence microscopy (XFM) was applied for direct visualization of the nanobioconjugate distribution through a single brain cancer cell at the submicrometer scale.
Rozhkova
Elena A
EA
The Center for Nanoscale Materials, Argonne National Laboratory, Argonne, Illinois 60439, USA. rozhkova@anl.gov
Ulasov
Ilya
I
Lai
Barry
B
Dimitrijevic
Nada M
NM
Lesniak
Maciej S
MS
Rajh
Tijana
T
D000911:Antibodies, Monoclonal / Q000494:pharmacology* / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000188:drug therapy*; D002384:Catalysis; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D006873:Hydroquinones / Q000737:chemistry / Q000494:pharmacology*; D008422:Materials Testing; D008954:Models, Biological; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology; D010316:Particle Size; D010777:Photochemistry; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry / Q000494:pharmacology*
D000911:Antibodies, Monoclonal; D006873:Hydroquinones; C009495:titanium dioxide; D014025:Titanium