title: Osteoporosis in adult Sri Lankan inflammatory bowel disease patients.
abstract: OBJECTIVE
  To determine if inflammatory bowel disease (IBD) is a risk factor for osteoporosis in adult Sri Lankans.
  
  
  METHODS
  We identified eligible subjects from among consecutive patients diagnosed with IBD who attended our outpatient clinic. We included only patients aged between 20 and 70 years. Patients who were pregnant, had significant comorbidity, or were on calcium supplements or treatment for osteoporosis within the past 6 mo, were excluded. Healthy, age- and sex-matched controls were also recruited, in a control to patient ratio of 3:1. Both groups were screened for osteoporosis using peripheral dual energy X-ray absorptiometry scanning.
  
  
  RESULTS
  The study population consisted of 111 IBD patients (male:female = 43:68; mean age 42.5 years) and 333 controls (male:female = 129:204; mean age 43.8 years). The occurrence of osteoporosis among IBD patients (13.5%) was significantly higher than among controls (4.5%) (P = 0.001). The frequency of osteoporosis was not significantly different between ulcerative colitis (14.45%) and Crohn's disease (10.7%). However, on multivariate analysis, only age (P = 0.001), menopause (P = 0.024) and use of systemic steroids (P < 0.001) were found to be associated independently with the occurrence of osteoporosis, while IBD, severity of disease, number of relapses, duration of illness or treatment other than systemic steroids were not.
  
  
  CONCLUSIONS
  IBD does not appear to be an independent risk factor for the occurrence of osteoporosis in this population. However, the use of systemic steroids was a risk factor.
authors.affiliation: Department of Medicine, Faculty of Medicine, University of Kelaniya, PO Box 6, Thalagolla Road, Ragama GQ11010, Sri Lanka. apdsilva@yahoo.com
authors.forename: Arjuna Priyadarsin
authors.initials: AP
authors.lastname: de Silva
authors.forename: Aranjan Lionel
authors.initials: AL
authors.lastname: Karunanayake
authors.forename: Thalahitiya Gamaralalage Iruka
authors.initials: TG
authors.lastname: Dissanayaka
authors.forename: Anuradha Supun
authors.initials: AS
authors.lastname: Dassanayake
authors.forename: Hewa Kattadi Kankanamgae Tilak
authors.initials: HK
authors.lastname: Duminda
authors.forename: Arunasalam
authors.initials: A
authors.lastname: Pathmeswaran
authors.forename: Ananda Rajitha
authors.initials: AR
authors.lastname: Wickramasinghe
authors.forename: Hithanadura Janaka
authors.initials: HJ
authors.lastname: de Silva
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000453:epidemiology* / Q000209:etiology / Q000503:physiopathology*; D011247:Pregnancy; D012044:Regression Analysis; D012307:Risk Factors; D013188:Sri Lanka / Q000453:epidemiology; D013256:Steroids / Q000009:adverse effects / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D013256:Steroids