title: Lipid profile in oral submucous fibrosis.
abstract: BACKGROUND
  Changes in lipid profile have long been associated with malignancies as lipids play a key role in maintenance of cell integrity. This study evaluated the alterations in extended lipid profile in untreated patients of oral submucous fibrosis (OSMF) and studied the correlation between lipid levels with tobacco consumption.
  
  
  METHODS
  In this hospital-based study, 65 clinically diagnosed and histopathologically proven patients of OSMF and 42 age and sex matched controls were studied. In these samples serum lipids including: (i) Total cholesterol, (ii) LDL cholesterol (LDLC), (iii) HDL cholesterol (HDLC) (iv) VLDL cholesterol (VLDLC) (v) triglycerides (vi) Apo-A1 (viii) Apo-B and (viii) LPa were analyzed.
  
  
  RESULTS
  A significant decrease in plasma total cholesterol, HDLC and Apo-A1 was observed in patients with OSMF as compared to the controls. Thus an inverse relationship between plasma lipid levels and patients was found in OSMF.
  
  
  CONCLUSIONS
  The lower levels of plasma cholesterol and other lipid constituents in patients might be due to their increased utilization. The findings strongly warrant an in-depth study of alterations in plasma lipid profile in patients with oral precancerous conditions.
authors.affiliation: Department of Pathology, M.L.N. Medical College, Allahabad, India. rm8509@gmail.com
authors.forename: Ravi
authors.initials: R
authors.lastname: Mehrotra
authors.forename: Shruti
authors.initials: S
authors.lastname: Pandya
authors.forename: Ajay Kumar
authors.initials: AK
authors.lastname: Chaudhary
authors.forename: Himanshu Pratap
authors.initials: HP
authors.lastname: Singh
authors.forename: Ritesh Kumar
authors.initials: RK
authors.lastname: Jaiswal
authors.forename: Mangal
authors.initials: M
authors.lastname: Singh
authors.forename: S C
authors.initials: SC
authors.lastname: Gupta
authors.forename: Mamta
authors.initials: M
authors.lastname: Singh
mesh_terms: D000293:Adolescent; D000328:Adult; D016632:Apolipoprotein A-I / Q000097:blood; D001055:Apolipoproteins B / Q000097:blood; D016022:Case-Control Studies; D002648:Child; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007194:India; D008055:Lipids / Q000097:blood*; D017270:Lipoprotein(a) / Q000097:blood; D008297:Male; D008875:Middle Aged; D009914:Oral Submucous Fibrosis / Q000097:blood* / Q000209:etiology; D011230:Precancerous Conditions / Q000097:blood / Q000209:etiology; D012907:Smoking; D019966:Substance-Related Disorders / Q000097:blood*; D055815:Young Adult
chemical_list: D016632:Apolipoprotein A-I; D001055:Apolipoproteins B; D008055:Lipids; D017270:Lipoprotein(a)