title: Human papillomavirus type 16 and 18 in primary lung cancers--a meta-analysis.
abstract: Lung cancer is the leading cause of cancer mortality worldwide. A possible carcinogenic role of human papillomavirus (HPV) has been investigated for >20 years and has major clinical and public health implications. We performed a meta-analysis to assess the prevalence of HPV16 and HPV18 in primary lung cancers (2435 subjects from 37 published studies). The overall HPV prevalence ranged from 0.0 to 78.3% with large heterogeneity across geographic regions and histological tissue types. A higher proportion, 50% (7/14), of the European studies reported low or no HPV prevalence (0-10%) compared with the Asian studies, 22% (4/18). When the analysis was limited to HPV16 and HPV18 prevalence, a higher prevalence in Asia (HPV16 = 11.6% and HPV18 = 8.8%) than in Europe (HPV16 = 3.5% and HPV18 = 3.6%) was observed. Studies using HPV-specific primers resulted in higher prevalence rates than consensus HPV primers (HPV16: Asia = 13% and Europe = 6%; HPV18: Asia = 13% and Europe = 5%). Further studies are needed to elucidate the role of HPV in lung carcinogenesis with careful thought given to study design and laboratory detection methods for a more accurate assessment of HPV status in lung tumors.
authors.affiliation: Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, USA.
authors.forename: Malini
authors.initials: M
authors.lastname: Srinivasan
authors.forename: Emanuela
authors.initials: E
authors.lastname: Taioli
authors.forename: Camille C
authors.initials: CC
authors.lastname: Ragin
mesh_terms: D001208:Asia / Q000453:epidemiology; D044466:Asian People / Q000235:genetics; D005060:Europe / Q000453:epidemiology; D052162:Human papillomavirus 16 / Q000235:genetics / Q000302:isolation & purification*; D052161:Human papillomavirus 18 / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications / Q000453:epidemiology / Q000821:virology*; D009656:North America / Q000453:epidemiology; D030361:Papillomavirus Infections / Q000150:complications / Q000453:epidemiology*; D016133:Polymerase Chain Reaction; D013020:South America / Q000453:epidemiology; D044465:White People / Q000235:genetics