title: Saponins as novel TNF-alpha inhibitors: isolation of saponins and a nor-pseudoguaianolide from Parthenium hysterophorus.
abstract: Two novel saponins and a 13-nor-pseudoguaianolide designated as hysterolactone were isolated from Parthenium hysterophorus. The two saponins were found to be potent inhibitors of TNF-alpha. Their mode of inhibition was studied through molecular modeling. The wet lab results were in concordance with the data obtained from docking experiments.
authors.affiliation: Bio-organic Chemistry Division, Indian Institute of Integrative Medicine (IIIM), Canal Road, Jammu Tawi-180001, India. bashah@iiim.res.in
authors.forename: Bhahwal Ali
authors.initials: BA
authors.lastname: Shah
authors.forename: Renu
authors.initials: R
authors.lastname: Chib
authors.forename: Pankaj
authors.initials: P
authors.lastname: Gupta
authors.forename: Vijay Kumar
authors.initials: VK
authors.lastname: Sethi
authors.forename: Surrinder
authors.initials: S
authors.lastname: Koul
authors.forename: Samar Singh
authors.initials: SS
authors.lastname: Andotra
authors.forename: Amit
authors.initials: A
authors.lastname: Nargotra
authors.forename: Sujata
authors.initials: S
authors.lastname: Sharma
authors.forename: Anjali
authors.initials: A
authors.lastname: Pandey
authors.forename: Sarang
authors.initials: S
authors.lastname: Bani
authors.forename: Basant
authors.initials: B
authors.lastname: Purnima
authors.forename: Subhash Chandra
authors.initials: SC
authors.lastname: Taneja
mesh_terms: D019659:Asteraceae / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry*; D012503:Saponins / Q000302:isolation & purification*; D045789:Sesquiterpenes, Guaiane / Q000302:isolation & purification*; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors*
chemical_list: C546815:13-nor-pseudoguaianolide; D010936:Plant Extracts; D012503:Saponins; D045789:Sesquiterpenes, Guaiane; D014409:Tumor Necrosis Factor-alpha