Association of posttraumatic stress disorder with low-grade elevation of C-reactive protein: evidence from the general population.
BACKGROUND
Posttraumatic stress disorder (PTSD) has been associated with several somatic diseases, and low-grade inflammation may be one psychobiological mechanism mediating this relationship. We assessed the association between PTSD and elevated serum levels of C-reactive protein (CRP; >3mg/L) in a large general population sample.


METHODS
About 3049 adults living in the community were included in the present study. CRP, lipoproteins and triglycerides were determined. Participants were also examined with regard to blood pressure, body mass index (BMI), physical activity, comorbid somatic diseases, medication, daily alcohol intake, and depression.


RESULTS
PTSD was diagnosed in 55 participants (1.8%), and low-grade inflammation (i.e. CRP >3mg/L) was found in 701 subjects (23.0%). PTSD positive participants had significantly higher odds for elevated CRP values than those without PTSD (OR=2.27; 95% CI: 1.32-3.93). Even after adjusting for sex, age, other sociodemographic factors, BMI, blood pressure, lipoproteins and triglycerides, physical activity, comorbid somatic diseases, daily alcohol intake, and trauma exposure, there were almost twofold higher odds for elevated CRP levels in participants with PTSD compared to those without PTSD (OR=1.87; 95% CI: 1.05-3.35).


CONCLUSIONS
Our findings suggest a close relationship between PTSD and low-grade inflammation possibly representing one psychobiological pathway from PTSD to poor physical health, particularly with respect to cardiovascular and pulmonary disease as well as diabetes.
Spitzer
Carsten
C
Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Hamburg-Eppendorf and Klinikum Eilbek (Schön Kliniken), Hamburg, Germany. c.spitzer@uke.uni-hamburg.de
Barnow
Sven
S
Völzke
Henry
H
Wallaschofski
Henri
H
John
Ulrich
U
Freyberger
Harald J
HJ
Löwe
Bernd
B
Grabe
Hans Joergen
HJ
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism*; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D008074:Lipoproteins; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009043:Motor Activity; D012111:Residence Characteristics; D012189:Retrospective Studies; D020886:Somatosensory Disorders / Q000209:etiology; D013313:Stress Disorders, Post-Traumatic / Q000378:metabolism* / Q000503:physiopathology; D014280:Triglycerides
D008074:Lipoproteins; D014280:Triglycerides; D002097:C-Reactive Protein