Self-organization of synthetic cholesteryl oligoethyleneglycol glycosides in water.
Lectin-sugar recognition systems are of interest in the pharmaceutical field, especially for the development of drug carriers, tailored for selective delivery. This paper deals with the anhydrous and aqueous self-organization properties of a synthetic cholesteryl oligoethyleneglycol glycoside with the aim of their incorporation in liposomes. Successive phases (lamellar, R3m, Im3m, micelles) have been described depending on water content and temperature. As a result of the presence of sugar residues and their hydration ability, this glycolipid shows a large range of packing parameter with increasing water content. However, because of oligoethyleneglycol spacer, a slight dehydration has been observed with increasing temperature from 20 to 60 degrees C.
Faivre
Vincent
V
Laboratoire de Physico-Chimie des Systèmes Polyphasés, UMR CNRS 8612-IFR 141, Université Paris-Sud, 5 rue J.B. Clement, 92296 Châtenay-Malabry, France. vincent.faivre@u-psud.fr
Bardonnet
Pierre-Louis
PL
Boullanger
Paul
P
Amenitsch
Heinz
H
Ollivon
Michel
M
Falson
Françoise
F
D002784:Cholesterol / Q000031:analogs & derivatives* / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry; D006027:Glycosides / Q000737:chemistry*; D015394:Molecular Structure; D011092:Polyethylene Glycols / Q000737:chemistry*; D014867:Water / Q000737:chemistry*
D004337:Drug Carriers; D006027:Glycosides; C118255:polyethylene glycol-cholesterol; D014867:Water; D011092:Polyethylene Glycols; D002784:Cholesterol