Thrombopoietin agonists for the treatment of thrombocytopenia in liver disease and hepatitis C.
Thrombocytopenia is a condition of unusually low level of platelets in blood, resulting from an imbalance between the production and destruction of platelets, and is associated with aplastic anemia, myelodysplasia, and idiopathic thrombocytopenic purpura (ITP). Thrombocytopenia can also be associated with severe chronic liver disease as a result of several factors that may act in concert, including reduced production of the endogenous thrombopoietic growth factor, thrombopoietin (TPO). This article examines the nature of thrombocytopenia, ITP, and TPO.
Dusheiko
Geoffrey
G
Centre for Hepatology, Royal Free and University College School of Medicine and Royal Free Hospital, Hampstead London, NW3 2QG, UK. g.dusheiko@medsch.ucl.ac.uk
D001565:Benzoates / Q000737:chemistry / Q000494:pharmacology; D001853:Bone Marrow / Q000821:virology; D002352:Carrier Proteins / Q000494:pharmacology; D006401:Hematologic Agents / Q000737:chemistry / Q000494:pharmacology; D006526:Hepatitis C / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D006834:Hydrazines / Q000737:chemistry / Q000494:pharmacology; D008103:Liver Cirrhosis / Q000150:complications; D008107:Liver Diseases / Q000150:complications*; D011720:Pyrazoles / Q000737:chemistry / Q000494:pharmacology; D011961:Receptors, Fc; D011993:Recombinant Fusion Proteins; D013921:Thrombocytopenia / Q000188:drug therapy* / Q000209:etiology; D013926:Thrombopoietin / Q000819:agonists* / Q000737:chemistry / Q000378:metabolism
D001565:Benzoates; D002352:Carrier Proteins; D006401:Hematologic Agents; D006834:Hydrazines; D011720:Pyrazoles; D011961:Receptors, Fc; D011993:Recombinant Fusion Proteins; D013926:Thrombopoietin; C488777:romiplostim; C520809:eltrombopag