Synthesis of 3-N-sugar-substituted-2, 4(1H,3H)-quinazolinedionesas anti-angiogenesis agents.
A series of novel 3-N-sugar-substituted quinazolinediones were synthesizedthrough the cyclization of the intermediate 2-aminobenzamides using triphosgene as the condensing reagent. Their anti-angiogenesis activities were investigated. The compound 3-(2'-aminoglucosyl)-2,4-(1H,3H)-quinazolinedione, (5d) showed good anti-angiogenesis activity.
Huang
Conghai
C
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China. michaelhchh@gmail.com
Meng
Xiangbao
X
Cui
Jingrong
J
Li
Zhongjun
Z
D020533:Angiogenesis Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D002642:Chick Embryo; D003500:Cyclization; D018919:Neovascularization, Physiologic / Q000187:drug effects; D010705:Phosgene / Q000031:analogs & derivatives / Q000737:chemistry; D052999:Quinazolinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D062367:ortho-Aminobenzoates / Q000737:chemistry
D020533:Angiogenesis Inhibitors; D052999:Quinazolinones; D062367:ortho-Aminobenzoates; D010705:Phosgene; C111044:bis(trichloromethyl) carbonate; C000219:anthranilamide