[Why so high incidence of HCC in Japan?].
The incidence of hepatocellular carcinoma (HCC) due to hepatitis C virus (HCV) in Japan is around 20 times higher than that in USA. The reason was the difference of HCV pandemic between Japan and USA. We calculated that the pandemic in Japan has been earlier around 30-40 years than that in USA by the molecular evolutionary analysis and the social backgrounds in both countries were also supported molecular evolutionary analysis.
Mizokami
Masashi
M
Research Center for Hepatitis & Immunology, Kohnodai Hospital, International Medical Center of Japan, Ichikawa, Japan.
D006528:Carcinoma, Hepatocellular / Q000453:epidemiology* / Q000821:virology*; D016174:Hepacivirus; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008113:Liver Neoplasms / Q000453:epidemiology* / Q000821:virology*; D014481:United States / Q000453:epidemiology