title: Squamous cell carcinoma of the rectum 21 years after radiotherapy for cervical carcinoma.
abstract: Squamous cell carcinoma (SCC) of the rectum is an extremely rare malignancy, accounting for 0.1-0.2% of rectal malignancies. It is associated with ulcerative colitis, prior radiation, schistosomiasis, ovarian cancer, endometrial cancer, human papilloma virus, colocutaneous fistulas and colonic duplication. Prior reported cases of SCC of the rectum have involved treatment with brachytherapy and external beam radiation. This case is particularly interesting because of the remote exposure of radiation (21 years previously) and the subsequent development of SCC of the rectum. Although extremely rare, SCC of the rectum can occur decades after radiation exposure.
authors.affiliation: Department of Gastroenterology, The University of Texas Health Science Center, Houston, TX 77030, USA.
authors.forename: Kevin K
authors.initials: KK
authors.lastname: Leung
authors.forename: Joseph
authors.initials: J
authors.lastname: Heitzman
authors.forename: Anand
authors.initials: A
authors.lastname: Madan
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000556:secondary* / Q000628:therapy; D003113:Colonoscopy; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D012004:Rectal Neoplasms / Q000175:diagnosis / Q000556:secondary* / Q000628:therapy; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000532:radiotherapy*