A new dilactone from the seeds of Gaultheria yunnanensis.
Gaultheriadiolide (1), a new compound, together with the known dauosterol (2), ginkgetin (3), myricetin (4), 6-ethyl-5-hydroxy-2,7-dimethoxy-1,4-naphthoquinone (5), ursolic acid (6), methyl salicylate 2-O-beta-D-xylosyl(1-->6)beta-D-glucopyranoside (7), and methyl salicylate 2-O-beta-D-glucopyranoside (8) were isolated from Gaultheria yunnanensis. The structure was elucidated on the basic of spectral analysis, especially 1D and 2D NMR. Primary bioassays showed that compound 1 had medium cytotoxic activity against HEp-2 and HepG2 Cells, with IC(50) of 23.337 microM and 29.4497 microM, respectively.
Li
Jun
J
School of Environmental Science & Resources, Guangxi Normal University, Guilin 541004, China. lijun9593@mailbox.gxnu.edu.cn
Li
Fu
F
Lu
Yuan-Yuan
YY
Su
Xiao-Jian
XJ
Huang
Cui-Ping
CP
Lu
Xue-Wen
XW
D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification*; D045744:Cell Line, Tumor; D004353:Drug Evaluation, Preclinical; D004365:Drugs, Chinese Herbal / Q000737:chemistry; D031282:Gaultheria / Q000737:chemistry*; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry / Q000302:isolation & purification*; D006801:Humans; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification*; D015394:Molecular Structure; D012639:Seeds / Q000737:chemistry
D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D006576:Heterocyclic Compounds, 4 or More Rings; D007783:Lactones; C546875:gaultheriadiolide