Lack of macrolide resistance in Chlamydia trachomatis after mass azithromycin distributions for trachoma.
We investigated antimicrobial drug resistance in ocular Chlamydia trachomatis 18 months after 4 biannual communitywide distributions of antimicrobial drugs in a region of Ethiopia where ocular strains of C. trachomatis are highly endemic. We found no significant differences in susceptibilities to azithromycin and doxycycline in 6 posttreatment and 4 pretreatment samples.
Hong
Kevin Cyrus
KC
University of California, San Francisco, California 94143, USA.
Schachter
Julius
J
Moncada
Jeanne
J
Zhou
Zhaoxia
Z
House
Jenafir
J
Lietman
Thomas M
TM
D000287:Administration, Topical; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D017963:Azithromycin / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D002692:Chlamydia trachomatis / Q000187:drug effects* / Q000235:genetics; D003513:Cycloheximide / Q000494:pharmacology; D004352:Drug Resistance, Microbial / Q000235:genetics*; D005002:Ethiopia / Q000453:epidemiology; D005128:Eye Diseases / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007223:Infant; D008297:Male; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy; D015995:Prevalence
D000900:Anti-Bacterial Agents; D017963:Azithromycin; D003513:Cycloheximide