Reproductive and fertility effects of an extract of Andrographis paniculata in male Wistar rats.
The possible effect of extract of Andrographis paniculata Nees (A paniculata) standardized to >or=10% andrographolide, the main bioactive component, on male fertility in albino Wistar rats was evaluated, by orally administering 0, 20, 200, and 1000 mg/kg of body weight per day, for 65 days prior to mating and 21 days during mating. The treated groups showed no signs of dose-dependent toxicity. The body weight gain and feed consumption were not affected at any of the dose levels. The testosterone levels and fertility indices in treatment groups were found to be comparable with that of the control indicating no effect on fertility. Total sperm count and sperm motility were not affected. The testes and epididymides did not show any gross and histopathological changes. Based on these findings, it can be concluded that the no-observed adverse effect level of extract of A paniculata (>or=10% andrographolide) was found to be more than 1000 mg/kg per day.
Allan
J Joshua
JJ
Department of Pharmacology and Toxicology, R&D Centre, Natural Remedies Pvt Ltd, 5B, Veerasandra Industrial Area, 19th KM Stone, Hosur Road, Near Electronic City, Bangalore 560 100, India. joshua@naturalremedy.com
Pore
Mukul P
MP
Deepak
M
M
Murali
B
B
Mayachari
Anand S
AS
Agarwal
Amit
A
D035685:Andrographis / Q000737:chemistry*; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004305:Dose-Response Relationship, Drug; D005298:Fertility / Q000187:drug effects*; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012015:Reference Standards; D012098:Reproduction / Q000187:drug effects*
D010936:Plant Extracts