Prediction of horizontal gene transfers in eukaryotes: approaches and challenges.
HGT (horizontal gene transfer) is recognized as an important force in bacterial evolution. Now that many eukaryotic genomes have been sequenced, it has become possible to carry out studies of HGT in eukaryotes. The present review compares the different approaches that exist for identifying HGT genes and assess them in the context of studying eukaryotic evolution. The metabolic evolution resource metaTIGER is then described, with discussion of its application in identification of HGT in eukaryotes.
Whitaker
John W
JW
Institute of Molecular and Cellular Biology, University of Leeds, Leeds, West Yorkshire LS2 9JT, UK. bgy1jww@leeds.ac.uk
McConkey
Glenn A
GA
Westhead
David R
DR
D000818:Animals; D005057:Eukaryotic Cells / Q000378:metabolism*; D019143:Evolution, Molecular; D022761:Gene Transfer, Horizontal / Q000235:genetics*; D006801:Humans; D010802:Phylogeny