title: Resection of hepatic metastasis after 5-fluorouracil and cofactor for colon cancer.
abstract: Hepatic metastases are common in colorectal cancer. However, only a small percentage of patients are candidates for resection. Neoadjuvant chemotherapy is used to downstage tumors so surgical resection becomes a viable option. We present a case of resection of hepatic metastasis from an 85-year-old patient with metastatic colorectal cancer after treatment with 5-Fluorouracil and 5,10-methylenetetrafolate (CoFactor), an analog of leucovorin, in a Phase II Clinical Trial. CoFactor was developed as a more active replacement of leucovorin to potentially allow reduced dosing of 5-FU. This could potentially be associated with diminished side effects. 5-Fluorouracil with leucovorin or CoFactor could represent another alternative for neoadjuvant chemotherapy prior to resection in metastatic colorectal cancer and warrants further studies, especially in elderly patients.
authors.affiliation: Department of Medicine, University of California San Diego, San Diego, California, USA.
authors.forename: Carrie L
authors.initials: CL
authors.lastname: Costantini
authors.forename: Tony R
authors.initials: TR
authors.lastname: Reid
authors.forename: Michael
authors.initials: M
authors.lastname: Bouvet
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy / Q000556:secondary / Q000601:surgery*; D000369:Aged, 80 and over; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D003110:Colonic Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use*; D006498:Hepatectomy; D006801:Humans; D002955:Leucovorin / Q000031:analogs & derivatives / Q000627:therapeutic use*; D008113:Liver Neoplasms / Q000188:drug therapy / Q000556:secondary / Q000601:surgery*; D020360:Neoadjuvant Therapy; D014803:Vitamin B Complex / Q000627:therapeutic use*
chemical_list: D000964:Antimetabolites, Antineoplastic; D014803:Vitamin B Complex; D002955:Leucovorin; D005472:Fluorouracil