title: Simultaneous imaging of magnetic resonance imaging and positron emission tomography by means of MRI-compatible optic fiber-based PET: a validation study in ex vivo rat brain.
abstract: OBJECTIVE
  We developed a new type of scintillation detector ring for positron emission tomography (PET). In this device the scintillation detectors were connected with 2.6 m length optic fibers to transport scintillation light to a photomultiplier (PMT) located apart from the detector rings. The present study aimed to test the possibility of simultaneous imaging with PET and magnetic resonance imaging (MRI) by means of the present PET device in ex vivo rat brain.
  
  
  METHODS
  The scintillation detector ring of 4 cm diameter was located in a magnetic field of 0.15 T open MRI. Simultaneous measurements of PET and MRI were performed in ex vivo rat brain after injection of (18)F-fluorodeoxyglucose ((18)F-FDG) 37 MBq and (18)F-NaF 37 MBq. Simultaneous data acquisition was performed for 10 min for PET and 5 min for T1-weighted MRI.
  
  
  RESULTS
  Simultaneous imaging of PET and MRI was possible without noticeable image distortion in the PET and MRI scans. In the fusion images, high uptake of (18)F-FDG was identified in the Harderian glands and striatum. High uptake of (18)F-NaF was found in the skull base and vault.
  
  
  CONCLUSIONS
  The present study indicated the possibility of simultaneous imaging of PET and MRI by means of optic fiber-based scintillation detectors.
authors.affiliation: Department of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita 565-0871, Japan. imaizumi@tracer.med.osaka-u.ac.jp
authors.forename: Masao
authors.initials: M
authors.lastname: Imaizumi
authors.forename: Seiichi
authors.initials: S
authors.lastname: Yamamoto
authors.forename: Makoto
authors.initials: M
authors.lastname: Kawakami
authors.forename: Masaaki
authors.initials: M
authors.lastname: Aoki
authors.forename: Eiji
authors.initials: E
authors.lastname: Sugiyama
authors.forename: Yasukazu
authors.initials: Y
authors.lastname: Kanai
authors.forename: Eku
authors.initials: E
authors.lastname: Shimosegawa
authors.forename: Jun
authors.initials: J
authors.lastname: Hatazawa
mesh_terms: D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging* / Q000473:pathology*; D001931:Brain Mapping / Q000379:methods*; D019788:Fluorodeoxyglucose F18 / Q000008:administration & dosage; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D055100:Optical Fibers; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals / Q000008:administration & dosage; D051381:Rats
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18