title: Backbone NMR resonance assignment of the Abelson kinase domain in complex with imatinib.
abstract: Imatinib (Glivec or Gleevec) potently inhibits the tyrosine kinase activity of BCR-ABL, a constitutively activated kinase, which causes chronic myelogenous leukemia (CML). Here we report the first almost complete backbone assignment of c-ABL kinase domain in complex with imatinib.
authors.affiliation: Biozentrum, University of Basel, Klingelbergstrasse 70, Basel, Switzerland.
authors.forename: Navratna
authors.initials: N
authors.lastname: Vajpai
authors.forename: André
authors.initials: A
authors.lastname: Strauss
authors.forename: Gabriele
authors.initials: G
authors.lastname: Fendrich
authors.forename: Sandra W
authors.initials: SW
authors.lastname: Cowan-Jacob
authors.forename: Paul W
authors.initials: PW
authors.lastname: Manley
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Jahnke
authors.forename: Stephan
authors.initials: S
authors.lastname: Grzesiek
mesh_terms: D000595:Amino Acid Sequence; D001549:Benzamides; D001665:Binding Sites; D002247:Carbon Isotopes / Q000737:chemistry; D016044:Fusion Proteins, bcr-abl / Q000037:antagonists & inhibitors*; D000068877:Imatinib Mesylate; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008969:Molecular Sequence Data; D008970:Molecular Weight; D009587:Nitrogen Isotopes / Q000737:chemistry; D010879:Piperazines / Q000737:chemistry*; D011485:Protein Binding; D047428:Protein Kinase Inhibitors / Q000737:chemistry; D011522:Protons; D011743:Pyrimidines / Q000737:chemistry*
chemical_list: D001549:Benzamides; D002247:Carbon Isotopes; D009587:Nitrogen Isotopes; D010879:Piperazines; D047428:Protein Kinase Inhibitors; D011522:Protons; D011743:Pyrimidines; D000068877:Imatinib Mesylate; D016044:Fusion Proteins, bcr-abl