Study on the potential anti-cancer activity of phosphonium and ammonium-based ionic liquids.
The anti-cancer activity and cytotoxicity of phosphonium and ammonium-based ionic liquids (ILs) have been determined for the first time via NCI's in vitro 60 human tumor cell lines. The preliminary SAR showed that the chain length of alkyl substitution on the cations plays crucial role towards anti-tumor activity and cytotoxicity of these ionic liquids. In general, phosphonium-based ILs were found to be more active and less cytotoxic as compared to ammonium ILs. Cell line data and hollow fiber study has demonstrated the potential of ILs to be developed as therapeutic agent.
Kumar
Vineet
V
Laboratory of Synthetic Chemistry, SAIC-Frederick Inc, National Cancer Institute at Frederick, Frederick, MD 21702, USA.
Malhotra
Sanjay V
SV
D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D052578:Ionic Liquids / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D009943:Organophosphorus Compounds / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D000644:Quaternary Ammonium Compounds / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D052578:Ionic Liquids; D009943:Organophosphorus Compounds; D000644:Quaternary Ammonium Compounds