Duloxetine, a centrally acting analgesic, in the treatment of patients with osteoarthritis knee pain: a 13-week, randomized, placebo-controlled trial.
Pain is a common cause of disability in osteoarthritis. Duloxetine, a serotonin and norepinephrine reuptake inhibitor (SNRI), has demonstrated analgesic effects in diabetic peripheral neuropathy and fibromyalgia. Considering its central mechanism of action, duloxetine may be effective in other pain states with evidence of central sensitization. Herein, we report the results of a 13-week, randomized, double-blind, placebo-controlled trial of duloxetine (60-120 mg/day) versus placebo in the treatment of knee pain in 231 patients meeting clinical and radiographic criteria for osteoarthritis of the knee. Duloxetine was superior to placebo on the primary efficacy measure (weekly mean 24-h pain scores) beginning at Week 1 and continuing through the treatment period (P < or = .05). There was also a significant improvement in the WOMAC physical functioning subscale and several other secondary outcomes. Adverse-event rates did not differ significantly between treatment groups (49.5% for duloxetine 60-120 mg/day, and 40.8% for placebo).
Chappell
Amy S
AS
Lilly Research Laboratories, Indianapolis, IN, USA i3 Statprobe, Ann Arbor, MI, USA Oregon Health & Science University, Portland, OR, USA Anderson & Collins Clinical Research, Inc., Edison, NJ, USA.
Ossanna
Melissa J
MJ
Liu-Seifert
Hong
H
Iyengar
Smriti
S
Skljarevski
Vladimir
V
Li
Linda Chunhong
LC
Bennett
Robert M
RM
Collins
Harry
H
D000368:Aged; D000700:Analgesics / Q000627:therapeutic use*; D000928:Antidepressive Agents / Q000627:therapeutic use*; D003863:Depression / Q000150:complications / Q000523:psychology; D004311:Double-Blind Method; D000068736:Duloxetine Hydrochloride; D005260:Female; D006801:Humans; D007717:Knee; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000150:complications*; D010146:Pain / Q000188:drug therapy* / Q000209:etiology*; D010147:Pain Measurement; D011569:Psychiatric Status Rating Scales; D013876:Thiophenes / Q000627:therapeutic use*; D016896:Treatment Outcome
D000700:Analgesics; D000928:Antidepressive Agents; D013876:Thiophenes; D000068736:Duloxetine Hydrochloride