title: Dehiscences of the bronchial joining after pneumonectomy for cancers: Incidence, gravity and risk factor.
abstract: Objectives To assess the incidence, severity and risk factors of bronchial fistula following pneumonectomy for cancer. Patients and methods From 1989 to 2003, 690 consecutive patients underwent a pneumonectomy for thoracic cancer in Sercive of Thoracic Surgery of the Teaching Hospital of Sainte Marguerite in Marseilles (France). The M/F sex ratio was 5,44 . Mean age was 59+/-9,9 years [16 - 81]. Clinical and surgical variables were studied retrospectively, and their possible association with the occurrence of a bronchial fistula was assessed by univariate and multivariate analysis. Results Fifty one patients (7,7%) experienced a bronchial fistula. This complication accounted for 56% (45/80) of the cases of reoperation and 25,5% (13/51) of early deaths. At univariate analysis, the following factors were identified as statistically significant: tobacco consumption (p<0,003), presence of COPD (p =0,02), preoperative radiotherapy (p=0,03), previous thoracic surgery (p=0,03), right side of the resection (p<0,001), hand-fashioned bronchial suture (p=0,05) and squamous cell histology (p= 0,04). Multivariate logistic regression analysis disclosed tobacco consumption (p=0,002), presence of COPD (p=0,01), previous thoracic surgery (p=0,03), extended procedures (p=0,05), right pneumonectomy (p<0,001) and squamous cell histology (p=0,02) as independent predictors of bronchial fistula. Conclusion The occurrence of a bronchial fistula following pneumonectomy is a frequent life threatening event, especially in cases of right sided resections and extended procedures. Tobacco cessation, preoperative rehabilitation, and reinforcement of the bronchial suture are possible means of prevention.
authors.forename: S
authors.initials: S
authors.lastname: Yena
authors.forename: C
authors.initials: C
authors.lastname: Doddoli
authors.forename: S
authors.initials: S
authors.lastname: Robitail
authors.forename: Xb
authors.initials: X
authors.lastname: D'Journo
authors.forename: A
authors.initials: A
authors.lastname: Aragon
authors.forename: M
authors.initials: M
authors.lastname: Mondini
authors.forename: A
authors.initials: A
authors.lastname: Marghli
authors.forename: P
authors.initials: P
authors.lastname: Thomas
authors.forename: R
authors.initials: R
authors.lastname: Giudicelli
authors.forename: S
authors.initials: S
authors.lastname: Soumare
authors.forename: P
authors.initials: P
authors.lastname: Fuentes