title: Exploration of homodimer receptor: homodimer protein interactions.
abstract: Homodimerisation is producing a protein?protein complex composed of two identical molecules. Dimerisation is a phenomenon often occurring in the regulation of biochemical systems like signal transduction pathways. We investigated whether the existence of a homodimer-activated receptor and the activation of homodimer transducers correspond to a more general pattern in cell signalling. We developed a workflow to merge data from the Gene Ontology and the BIND database to produce a list of interactions between homodimer receptors and homodimer proteins. Finally, we found a prevalence of homodimer-homodimer interactions in signalling systems in human cells.
authors.affiliation: Group of Systems Biology and Bioinformatics, Department of Computer Science, University of Rostock, 18051 Rostock, Germany. julio.vera@uni-rostock.de
authors.forename: Julio
authors.initials: J
authors.lastname: Vera
authors.forename: Taesoo
authors.initials: T
authors.lastname: Kwon
authors.forename: Ulf
authors.initials: U
authors.lastname: Schmitz
authors.forename: Walter
authors.initials: W
authors.lastname: Kolch
mesh_terms: D001665:Binding Sites; D019295:Computational Biology / Q000379:methods*; D019281:Dimerization; D006801:Humans; D055503:Protein Multimerization; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D011506:Proteins