title: [Antibiotic prophylaxis in colorectal surgery].
abstract: OBJECTIVE
  Antibiotic (ATB) prophylaxis is generaly recommended in surgery. There is an important role in colorectal surgery especially. Colorectal surgery is associated with a particularly high risk of post-operative infection because of contamination of the wound with faecal bacteria. ATB prophylaxis decreases surgical wound infection, morbidity and mortality as well. Morbidity and mortality are associated with longer hospital stays and increased costs of care.
  
  
  METHODS
  At surgical department of Faculty hospital Brno, during March-June 2008 an 88 patients were operated because of different diagnoses in colorectum. Both an emergent and schedule operations were made. Type of ATBs, time of application before operation, reapplication after operation and surgical site infection (SSI), in - hospital stay were followed up prospectively. SSI were divided into superficial, deep and intraabdominal. Data were analyse statistically.
  
  
  RESULTS
  The most used combination of ATBs, almost in 91%, were Cefazoline and Metronidazole. In 50% were time of application till 20 minutes before incision. Only in 17% were time of application in interval 20-30 minutes before incision, which is recommended. We noticed 25 SSI. We prove that patients with SSI has almost two-times longer in-hospital stay. Enterococcus and enterobacterias were the most common etiological agents.
  
  
  CONCLUSIONS
  ATB prophylaxis is indicated in colorectal surgery. It has to be applied in correct dose and right time before operation to decrease SSI.
authors.affiliation: Chirurgická klinika FN Brno-Bohunice, LF MU v Brne.
authors.forename: R
authors.initials: R
authors.lastname: Hrivnák
authors.forename: I
authors.initials: I
authors.lastname: Hanke
authors.forename: M
authors.initials: M
authors.lastname: Hansliánová
authors.forename: Z
authors.initials: Z
authors.lastname: Kala
authors.forename: A
authors.initials: A
authors.lastname: Sevcíková
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D019072:Antibiotic Prophylaxis; D003106:Colon / Q000601:surgery*; D013505:Digestive System Surgical Procedures / Q000009:adverse effects; D004359:Drug Therapy, Combination; D006801:Humans; D012007:Rectum / Q000601:surgery*; D013530:Surgical Wound Infection / Q000517:prevention & control*
chemical_list: D000900:Anti-Bacterial Agents