title: Static and dynamic characteristics of cerebral blood flow during the resting state.
abstract: In this study, the static and dynamic characteristics of cerebral blood flow (CBF) in the resting state were investigated using an arterial spin labeling (ASL) perfusion imaging technique. Consistent with previous PET results, static CBF measured by ASL was significantly higher in the posterior cingulate cortex (PCC), thalamus, insula/superior temporal gyrus (STG) and medial prefrontal cortex (MPFC) than the average CBF of the brain. The dynamic measurement of CBF fluctuations showed high correlation (functional connectivity) between components in the default mode network. These brain regions also had high local temporal synchrony and high fluctuation amplitude, as measured by regional homogeneity (ReHo) and amplitude of low-frequency fluctuation (ALFF) analyses. The spatial pattern of the static CBF correlated well with that of the dynamic indices. The high static and dynamic activities in the PCC, MPFC, insula/STG and thalamus suggest that these regions play a vital role in maintaining and facilitating fundamental brain functions.
authors.affiliation: Neuroimaging Research Branch, National Institute on Drug Abuse, National Institutes of Health, 251 Bayview Blvd., Suite 200, Baltimore, MD 21224, USA.
authors.forename: Qihong
authors.initials: Q
authors.lastname: Zou
authors.forename: Changwei W
authors.initials: CW
authors.lastname: Wu
authors.forename: Elliot A
authors.initials: EA
authors.lastname: Stein
authors.forename: Yufeng
authors.initials: Y
authors.lastname: Zang
authors.forename: Yihong
authors.initials: Y
authors.lastname: Yang
mesh_terms: D000328:Adult; D001921:Brain / Q000098:blood supply* / Q000502:physiology*; D001931:Brain Mapping; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005260:Female; D006801:Humans; D007700:Kinetics; D008279:Magnetic Resonance Imaging; D008297:Male; D055420:Perfusion Imaging; D012146:Rest / Q000502:physiology*; D013113:Spin Labels
chemical_list: D013113:Spin Labels