title: [A case of double cancer of sigmoid colon cancer with lung metastases, peritoneal dissemination and early gastric cancer responding to S-1].
abstract: A 73-year-old man was referred to our hospital with complaints of constipation and defecation caused by a sigmoid colon tumor. After examination, he was diagnosed as sigmoid colon cancer with lung metastasis, peritoneal dissemination and early gastric cancer. To prevent bowel obstruction, a sigmoid colon resection was performed. On postoperative day 20, S-1 (100 mg/body for 4 weeks followed by 2 drug-free weeks) treatment was started. After 13 courses of treatment, gastrointestinal fiberscope revealed that the gastric cancer was remarkably reduced, and after 16 courses, computed tomography revealed that the lung metastasis was remarkably reduced. Although after 12 courses, elevation of bilirubin, the treatment could be possible to continued on a lowered dose of S-1 from 100 mg to 80 mg/body. Twenty-four months after the operation, good control of cancer has been maintained, and the treatment is continuing. S-1 treatment was proved effective for double cancer of the advanced colorectal cancer and the gastric cancer.
authors.affiliation: Dept. of Surgery, TOYOTA Memorial Hospital.
authors.forename: Masahiko
authors.initials: M
authors.lastname: Sugiura
authors.forename: Hideki
authors.initials: H
authors.lastname: Tsuji
authors.forename: Atsushi
authors.initials: A
authors.lastname: Sato
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Haruki
authors.forename: Hiroki
authors.initials: H
authors.lastname: Kurehara
authors.forename: Yuzo
authors.initials: Y
authors.lastname: Maeda
authors.forename: Yushi
authors.initials: Y
authors.lastname: Yamakawa
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Tatematsu
authors.forename: Nanako
authors.initials: N
authors.lastname: Ando
authors.forename: Yorisuke
authors.initials: Y
authors.lastname: Maeda
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Yamakawa
mesh_terms: D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D004338:Drug Combinations; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000556:secondary; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000188:drug therapy; D010094:Oxonic Acid / Q000627:therapeutic use*; D010537:Peritoneum / Q000473:pathology; D012811:Sigmoid Neoplasms / Q000188:drug therapy*; D013274:Stomach Neoplasms / Q000188:drug therapy*; D005641:Tegafur / Q000627:therapeutic use*
chemical_list: D000964:Antimetabolites, Antineoplastic; D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid