Invasive Aspergillus fumigatus infection after Plasmodium falciparum malaria in an immuno-competent host: case report and review of literature.
Invasive fungal infection is rarely reported in association with malaria, even though malaria-associated inhibition of phagocyte function is a well-known condition. Invasive aspergillosis is frequently found in severely immuno-compromised patients but not in healthy individuals. Here, a case of pulmonary invasive aspergillosis in a previously healthy patient with severe P. falciparum malaria is presented, who was successfully treated with voriconazol and caspofungin. This is the first survival of malaria-associated invasive aspergillosis.
Eckerle
Isabella
I
Section Clinical Tropical Medicine, University Hospital Heidelberg, Heidelberg, Germany. isabella.eckerle@med.uni-heidelberg.de
Ebinger
Damaris
D
Gotthardt
Daniel
D
Eberhardt
Ralf
R
Schnabel
Philipp A
PA
Stremmel
Wolfgang
W
Junghanss
Thomas
T
Eisenbach
Christoph
C
D000935:Antifungal Agents / Q000627:therapeutic use; D001232:Aspergillus fumigatus / Q000302:isolation & purification*; D000077336:Caspofungin; D054714:Echinocandins / Q000627:therapeutic use; D006801:Humans; D055744:Invasive Pulmonary Aspergillosis / Q000175:diagnosis* / Q000188:drug therapy; D055666:Lipopeptides; D016778:Malaria, Falciparum / Q000150:complications*; D008297:Male; D008875:Middle Aged; D011743:Pyrimidines / Q000627:therapeutic use; D014230:Triazoles / Q000627:therapeutic use; D065819:Voriconazole
D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D011743:Pyrimidines; D014230:Triazoles; D000077336:Caspofungin; D065819:Voriconazole