title: Solid-phase synthesis and DNA binding studies of dichloroplatinum(ii) conjugates of dicarba analogues of octreotide as new anticancer drugs.
abstract: The first dichloroplatinum(ii) conjugates of dicarba analogues of octreotide, which is expected to act as a 'tumour-targeting device', have been efficiently synthesized following a stepwise solid-phase approach; these compounds emulate the mechanism of cisplatin since they form a 1,2-intrastrand cross-link with two consecutive guanines of an oligonucleotide.
authors.affiliation: Departament de Química Orgànica-IBUB, Universitat de Barcelona, Barcelona, E-08028, Spain.
authors.forename: Flavia
authors.initials: F
authors.lastname: Barragán
authors.forename: Virtudes
authors.initials: V
authors.lastname: Moreno
authors.forename: Vicente
authors.initials: V
authors.lastname: Marchán
mesh_terms: D018931:Antineoplastic Agents, Hormonal / Q000737:chemistry*; D001665:Binding Sites; D002713:Chlorine; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D003996:Dicamba / Q000031:analogs & derivatives* / Q000737:chemistry; D006801:Humans; D015282:Octreotide / Q000138:chemical synthesis* / Q000737:chemistry*; D009944:Organoplatinum Compounds / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D018931:Antineoplastic Agents, Hormonal; D009944:Organoplatinum Compounds; D002713:Chlorine; D004247:DNA; D015282:Octreotide; D003996:Dicamba