Pharmacokinetics of prophylactic micafungin in very-low-birth-weight infants.
We evaluated the use of micafungin as a prophylaxis in very-low-birth-weight infants. Micafungin was first administered to 25 very-low-birth-weight infants 12 to 24 hours after birth at a dose of 1 mg/kg/d. the apparent volume of distribution, the apparent elimination rate constant, the elimination half-life, and the total body clearance (mean +/- SD) were 0.76 +/- 0.28 L/kg, 0.12 +/- 0.041 1/h, 6.7 +/- 2.2 h, and 0.089 +/- 0.047 L/kg/h, respectively.
Kawada
Mayumi
M
Department of Pediatrics, Kagawa University, Kita-gun Kagawa, Japan.
Fukuoka
Noriyasu
N
Kondo
Masatoshi
M
Okazaki
Kaoru
K
Kusaka
Takashi
T
Kawada
Kou
K
Itoh
Susumu
S
D000935:Antifungal Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D018890:Chemoprevention / Q000379:methods*; D054714:Echinocandins / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006801:Humans; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight; D055666:Lipopeptides / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000077551:Micafungin; D009181:Mycoses / Q000517:prevention & control*
D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D000077551:Micafungin