title: Young-age onset of colorectal cancer in Israel.
abstract: OBJECTIVE
  The study was conducted to investigate the differences in clinical-pathological, ethnic, and demographic presentations and the expression of mismatch repair proteins in a cohort of young-onset (</=50 years) versus late-onset Israeli patients (>50 years) with colorectal cancer.
  
  
  METHODS
  Clinical, demographic, and histopathological data of patients with colorectal cancer were collected retrospectively from medical records and pathology reports.
  
  
  RESULTS
  Ninety patients, 50 years of age or younger with a mean age of 42 years were compared with a group of 190 patients above 50 years of 50 (see Table 1). Sixty percent of the young-onset patients were females, compared to 40% in the older age group (P = 0.02). Twenty-one percent of the young-onset patients were Arabs as compared to 2% of older-onset patients (P = 0.001). Younger patients displayed a higher percentage of mucinous cancers and a higher percentage of diagnosis at an advanced stage of disease; 40% of young-onset versus 31% of older-onset patients presented Duke's stages C and D (P = 0.02).
  
  
  CONCLUSIONS
  Younger age of onset colorectal cancer in our cohort of Israeli patients is associated with higher percentage of Arab patients, mucinous cancers, female gender, and advanced stage at diagnosis.
authors.affiliation: Department of Surgery, Meir Medical Center, Kfar Sava, Israel. neufeldd@clalit.org.il
authors.forename: D
authors.initials: D
authors.lastname: Neufeld
authors.forename: B
authors.initials: B
authors.lastname: Shpitz
authors.forename: N
authors.initials: N
authors.lastname: Bugaev
authors.forename: M
authors.initials: M
authors.lastname: Grankin
authors.forename: J
authors.initials: J
authors.lastname: Bernheim
authors.forename: E
authors.initials: E
authors.lastname: Klein
authors.forename: Y
authors.initials: Y
authors.lastname: Ziv
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000453:epidemiology* / Q000473:pathology* / Q000628:therapy; D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D018912:Arabs / Q000706:statistics & numerical data; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D015179:Colorectal Neoplasms / Q000453:epidemiology* / Q000473:pathology* / Q000628:therapy; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007557:Israel / Q000453:epidemiology; D007585:Jews / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011336:Probability; D011379:Prognosis; D012189:Retrospective Studies; D018570:Risk Assessment; D017678:Sex Distribution; D016019:Survival Analysis; D055815:Young Adult