title: Crohn disease: correlation of findings at contrast-enhanced US with severity at endoscopy.
abstract: OBJECTIVE
  To evaluate the effectiveness of visualization of vascularization at contrast material-enhanced ultrasonography (US) for assessment of the activity of Crohn disease, with severity grade determined at endoscopy as the reference standard.
  
  
  METHODS
  Ethics committee approval and written informed consent were obtained. Sixty-one patients (age range, 21-67 years; median age, 36 years) who had Crohn disease underwent both colonoscopy and US, including color Doppler and contrast-enhanced US, prospectively. To assess the vascularization of the involved bowel loop in a region expected to be seen at colonoscopy, the contrast agent uptake was measured by using quantitative analysis of the enhancement in regions of interest. Measurement of contrast enhancement was assessed as the increase in wall brightness with respect to the baseline brightness. Results were compared with the severity grade determined at endoscopy by using the area under the receiver operating characteristic curve and logistic regression analysis.
  
  
  RESULTS
  Colonoscopy showed inflammatory lesions in 53 patients (mild disease, seven; moderate disease, 12; and severe disease, 34). Bowel wall thickness and grade at color Doppler US (P = .019 and .002, respectively) correlated with severity grade at endoscopy. Mural contrast enhancement in patients with active disease at endoscopy was markedly increased in comparison with enhancement in patients with inactive disease (P < .001). Multivariate logistic regression analysis revealed that an increase in wall brightness was a significant and independent variable predictive of severity grade at endoscopy. A threshold brightness value of percentage of increase of 46% had a sensitivity and specificity of 96% and 73%, respectively, in the prediction of moderate or severe grade for inflammation at endoscopy.
  
  
  CONCLUSIONS
  Quantitative measurements of bowel enhancement obtained by using contrast-enhanced US correlate with severity grade determined at endoscopy. Contrast-enhanced US could be a useful technique to monitor the activity of Crohn disease.
  
  
  BACKGROUND
  http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.2531082269/-/DC1.
authors.affiliation: Department of Radiology, Hospital Universitario Dr Peset, 46017 Valencia, Spain. ripolles_tom@gva.es
authors.forename: Tomás
authors.initials: T
authors.lastname: Ripollés
authors.forename: María J
authors.initials: MJ
authors.lastname: Martínez
authors.forename: Jose M
authors.initials: JM
authors.lastname: Paredes
authors.forename: Esther
authors.initials: E
authors.lastname: Blanc
authors.forename: Lucía
authors.initials: L
authors.lastname: Flors
authors.forename: Fructuoso
authors.initials: F
authors.lastname: Delgado
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003113:Colonoscopy; D003287:Contrast Media; D003424:Crohn Disease / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012372:ROC Curve; D012720:Severity of Illness Index; D018615:Ultrasonography, Doppler, Color
chemical_list: D003287:Contrast Media