title: Pineal function: impact of microarray analysis.
abstract: Microarray analysis has provided a new understanding of pineal function by identifying genes that are highly expressed in this tissue relative to other tissues and also by identifying over 600 genes that are expressed on a 24-h schedule. This effort has highlighted surprising similarity to the retina and has provided reason to explore new avenues of study including intracellular signaling, signal transduction, transcriptional cascades, thyroid/retinoic acid hormone signaling, metal biology, RNA splicing, and the role the pineal gland plays in the immune/inflammation response. The new foundation that microarray analysis has provided will broadly support future research on pineal function.
authors.affiliation: Section on Neuroendocrinology, Program on Developmental Endocrinology and Genetics, NICHD, National Institutes of Health, Bethesda, MD 20892, USA. kleind@mail.nih.gov
authors.forename: David C
authors.initials: DC
authors.lastname: Klein
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Bailey
authors.forename: David A
authors.initials: DA
authors.lastname: Carter
authors.forename: Jong-so
authors.initials: JS
authors.lastname: Kim
authors.forename: Qiong
authors.initials: Q
authors.lastname: Shi
authors.forename: Anthony K
authors.initials: AK
authors.lastname: Ho
authors.forename: Constance L
authors.initials: CL
authors.lastname: Chik
authors.forename: Pascaline
authors.initials: P
authors.lastname: Gaildrat
authors.forename: Fabrice
authors.initials: F
authors.lastname: Morin
authors.forename: Surajit
authors.initials: S
authors.lastname: Ganguly
authors.forename: Martin F
authors.initials: MF
authors.lastname: Rath
authors.forename: Morten
authors.initials: M
authors.lastname: Møller
authors.forename: David
authors.initials: D
authors.lastname: Sugden
authors.forename: Zoila G
authors.initials: ZG
authors.lastname: Rangel
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Munson
authors.forename: Joan L
authors.initials: JL
authors.lastname: Weller
authors.forename: Steven L
authors.initials: SL
authors.lastname: Coon
mesh_terms: D000818:Animals; D002940:Circadian Rhythm / Q000235:genetics*; D006801:Humans; D008550:Melatonin / Q000502:physiology; D009474:Neurons / Q000502:physiology; D020411:Oligonucleotide Array Sequence Analysis; D010870:Pineal Gland / Q000502:physiology*; D015398:Signal Transduction / Q000235:genetics*
chemical_list: D008550:Melatonin