A metal-free general procedure for oxidation of secondary amines to nitrones.
An efficient and metal-free protocol for direct oxidation of secondary amines to nitrones has been developed, using Oxone in a biphasic basic medium as the sole oxidant. The method is general and tolerant with other functional groups or existing stereogenic centers, providing rapid access to enantiomerically pure compounds in good yields.
Gella
Carolina
C
Universitat Autònoma de Barcelona, Departament de Química, 08193 Bellaterra, Spain.
Ferrer
Eric
E
Alibés
Ramon
R
Busqué
Félíx
F
de March
Pedro
P
Figueredo
Marta
M
Font
Josep
J
D000588:Amines / Q000737:chemistry*; D009589:Nitrogen Oxides / Q000737:chemistry*; D010084:Oxidation-Reduction; D013237:Stereoisomerism
D000588:Amines; D009589:Nitrogen Oxides; C015388:nitrones