title: Towards no-scar cardiac surgery - minimally invasive access through umbilicus for aortic valve replacement.
abstract: There is an ever-growing trend towards less-invasive procedures in all fields of medicine. We designed an animal study to prove the concept that trans-apical aortic valve replacement from an incision within the umbilicus through a single channel for instruments is feasible, which would be a major leap towards no-scar cardiac surgery. In three adult pigs, after creating a single 3-cm incision at a place where the human umbilicus would be, we introduced a 30F sheath through a tunnel created by an endoscopic vein-harvesting device up to the cardiac apex, through it and up to the left ventricle simulating the approach for trans-apical aortic valve replacement. We used a standard Amplatz nitinol occluder to seal the defect in ventricle wall later. The animals were followed up for 1h. Blood loss was minimal, and no tamponade occurred in any of the animals. In addition, we performed a test with water column static pressure to evaluate the impact of preclotting on the sealing properties of the occluders: 1 min flow-through was 2860+/-176 ml for the standard occluders and 348+/-56 ml for preclotted occluders (p<0.001).
authors.affiliation: Department of Cardio-Vascular Surgery, Centre Hospitalier Universitaire Vaudois, CHUV, BH10-275, Rue du Bugnon 46, CH-1011 Lausanne, Switzerland. martins.kalejs@stradini.lv
authors.forename: Martins
authors.initials: M
authors.lastname: Kalejs
authors.forename: Enrico
authors.initials: E
authors.lastname: Ferrari
authors.forename: Ludwig Karl
authors.initials: LK
authors.lastname: von Segesser
mesh_terms: D000818:Animals; D001021:Aortic Valve / Q000601:surgery*; D016063:Blood Loss, Surgical / Q000517:prevention & control; D005240:Feasibility Studies; D005471:Fluoroscopy; D019918:Heart Valve Prosthesis Implantation / Q000295:instrumentation / Q000379:methods*; D019060:Minimally Invasive Surgical Procedures / Q000295:instrumentation / Q000379:methods; D015641:Radiography, Interventional / Q000379:methods; D034421:Sus scrofa; D014472:Umbilicus / Q000601:surgery; D020535:Video-Assisted Surgery / Q000379:methods