[Rate of free radical peroxidation of lipids, activity of adenylate cyclase and permeability of plasma membrane for Ca2+ ions in cells of peripheral blood of sheep exposed to low-level radiation].
Chronic exposure of sheep at doses 0.1 and 0.5 Gy resulted in reduced contents of malondialdehyde, of diene and of triene conjugates and alpha-tocopherol with simultaneous increase in the retinol level in blood plasma. In lymphocytes of peripheral blood, the activity of adenylate cyclase was decreased, and in thrombocytes the phase pattern of changes was marked. The enzyme activity in blood cells stimulated by forskolin and prostaglandid E1 was more pronounced. The estimation of the plasma membrane permeability for Ca2+ ions in peripheral blood neutrophils has revealed nonlinear pattern of variations. Erythrocytes the showed increase in passive permeability of plasma membrane for Ca2+ ions.
Mirzoev
E B
EB
Kobialko
V O
VO
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D001773:Blood Cells / Q000378:metabolism / Q000528:radiation effects*; D002118:Calcium / Q000378:metabolism*; D002463:Cell Membrane Permeability / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D005260:Female; D005609:Free Radicals / Q000378:metabolism*; D005720:Gamma Rays; D015227:Lipid Peroxidation / Q000528:radiation effects*; D008315:Malondialdehyde / Q000097:blood / Q000378:metabolism; D012756:Sheep / Q000097:blood / Q000378:metabolism; D014801:Vitamin A / Q000097:blood / Q000378:metabolism; D014916:Whole-Body Irradiation; D024502:alpha-Tocopherol / Q000097:blood / Q000378:metabolism
D005609:Free Radicals; D014801:Vitamin A; D008315:Malondialdehyde; D000262:Adenylyl Cyclases; D024502:alpha-Tocopherol; D002118:Calcium