title: [Analysis of pancreatic leaking-related risk factors after pancreaticoduodenectomy].
abstract: OBJECTIVE
  To analysis the risk factors of pancreatic fistula after pancreaticoduodenectomy (PD).
  
  
  METHODS
  A retrospective clinical study had been done in 97 patients who underwent PD between June 2001 and June 2006. The two groups were first compared by the univariate analysis;logistic regression was then used to determine the effect of multiple factors on pancreatic fistula. A P-value of less than 0.05 was considered to be statistically significant.
  
  
  RESULTS
  Of the 97 patients, 13 patients were identified as having pancreatic fistula. Factors significantly increasing the risk of pancreatic fistula by univariate analysis included preoperative serum total bilirubin (P = 0.038), operative time (P = 0.003) and whether or not Braun anastomosis (P = 0.034), and prophylactic use of somatostatin (P = 0.003) after operation. A multivariate logistic regression analysis revealed the factors most highly associated with pancreatic fistula to be preoperative serum total bilirubin (OR = 11.687, P = 0.021) and postoperative prophylactic use of somatostatin (OR = 0.056, P = 0.020).
  
  
  CONCLUSIONS
  Preoperative serum total bilirubin more than 170 mmol/L was a risk factor of pancreatic fistula after PD, and postoperative prophylactic use of somatostatin was a protect factor of pancreatic fistula after PD.
authors.affiliation: Department of General Surgery, the First Affiliated Hospital of China Medical University, Shenyang 110001, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.forename: Ming
authors.initials: M
authors.lastname: Dong
authors.forename: Jian-ping
authors.initials: JP
authors.lastname: Zhou
authors.forename: Yu-ji
authors.initials: YJ
authors.lastname: Li
authors.forename: Fan-min
authors.initials: FM
authors.lastname: Kong
authors.forename: Yu-lin
authors.initials: YL
authors.lastname: Tian
mesh_terms: D000328:Adult; D000368:Aged; D001663:Bilirubin / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010185:Pancreatic Fistula / Q000209:etiology*; D016577:Pancreaticoduodenectomy / Q000009:adverse effects*; D011183:Postoperative Complications / Q000209:etiology; D012189:Retrospective Studies; D012307:Risk Factors; D013004:Somatostatin / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D013004:Somatostatin; D001663:Bilirubin