title: Chiral Brønsted acid catalyzed Friedel-Crafts alkylation reactions.
abstract: The asymmetric Friedel-Crafts reaction is one of the most powerful methods to synthesize optically active aromatic compounds. Particularly, the Friedel-Crafts alkylation of arenes with unsaturated compounds activated by chiral Brønsted acids provides direct access to enantiopure aromatic derivatives with perfect atom economy. In this tutorial review, recent progress in the development of chiral Brønsted acid-catalyzed asymmetric Friedel-Crafts reactions is presented.
authors.affiliation: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai, 200032, China. slyou@mail.sioc.ac.cn
authors.forename: Shu-Li
authors.initials: SL
authors.lastname: You
authors.forename: Quan
authors.initials: Q
authors.lastname: Cai
authors.forename: Mi
authors.initials: M
authors.lastname: Zeng