A convenient and efficient protocol for the synthesis of 5-aryl-1,3-diphenylpyrazole catalyzed by hydrochloric acid under ultrasound irradiation.
The synthesis of 5-aryl-1,3-diphenylpyrazole via the reactions of 3-aryl-2,3-epoxy-1-phenyl-1-propanone with phenylhydrazine was carried out in 69-99% yields at room temperature under ultrasound irradiation. This method provides several advantages such as operational simplicity, higher yield and environment friendly.
Li
Ji-Tai
JT
College of Chemistry and Environmental Science, Hebei University, Key Laboratory of Analytical Science and Technology of Hebei Province, Baoding 071002, PR China. lijitai@hbu.cn
Yin
Ying
Y
Li
Ling
L
Sun
Ming-Xuan
MX
D002384:Catalysis; D006851:Hydrochloric Acid / Q000737:chemistry* / Q000528:radiation effects; D010659:Phenylhydrazines / Q000737:chemistry* / Q000528:radiation effects*; D011407:Propane / Q000737:chemistry* / Q000528:radiation effects*; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000528:radiation effects*; D011829:Radiation Dosage; D013010:Sonication / Q000379:methods*
D010659:Phenylhydrazines; D011720:Pyrazoles; C030299:phenylhydrazine; D006851:Hydrochloric Acid; D011407:Propane