title: Applications of bioinformatics to protein structures: how protein structure and bioinformatics overlap.
abstract: In this chapter, we will focus on the role of bioinformatics to analyze a protein after its protein structure has been determined. First, we present how to validate protein structures for quality assurance. Then, we discuss how to analyze protein-protein interfaces and how to predict the biomolecule which is the biological oligomeric state of the protein. Finally, we discuss how to search for homologs based on the 3-D structure which is an essential step for understanding protein function.
authors.affiliation: Burnham Institute for Medical Research, La Jolla, CA, USA.
authors.forename: Gye Won
authors.initials: GW
authors.lastname: Han
authors.forename: Chris
authors.initials: C
authors.lastname: Rife
authors.forename: Michael R
authors.initials: MR
authors.lastname: Sawaya
mesh_terms: D019295:Computational Biology; D030562:Databases, Protein; D054730:Protein Interaction Domains and Motifs; D025941:Protein Interaction Mapping / Q000706:statistics & numerical data; D011506:Proteins / Q000737:chemistry*; D012984:Software; D040681:Structural Homology, Protein
chemical_list: D011506:Proteins