title: Role of EBV in microRNA dysregulation in Burkitt lymphoma.
abstract: Since its discovery as the first human tumor virus, Epstein-Barr virus (EBV) has been implicated in the development of a wide range of B-cell lymphoproliferative disorders, the first being Burkitt lymphoma. However, the exact mechanism by which EBV promotes oncogenesis is still matter of discussion. A role in EBV-mediated transformation has been proposed for a novel described class of small non-coding RNAs, the microRNAs (miRNAs). EBV encodes viral miRNAs, through which it may interfere with the physiological regulation exterted by cellular miRNAs. In addition, EBV-coded proteins may also disturb the well-orchestrated mechanisms of regulation of cellular function. In this review, we will focus on the role of EBV in malignant transformation of Burkitt lymphoma, with a particular insight in the interplay between the virus and cellular miRNAs.
authors.affiliation: Department of Human Pathology and Oncology, University of Siena, Via delle Scotte, 6, 53100 Siena, Italy.
authors.forename: Giulia
authors.initials: G
authors.lastname: De Falco
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Antonicelli
authors.forename: Anna
authors.initials: A
authors.lastname: Onnis
authors.forename: Stefano
authors.initials: S
authors.lastname: Lazzi
authors.forename: Cristiana
authors.initials: C
authors.lastname: Bellan
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Leoncini
mesh_terms: D000818:Animals; D002051:Burkitt Lymphoma / Q000821:virology*; D020031:Epstein-Barr Virus Infections / Q000821:virology*; D004854:Herpesvirus 4, Human / Q000502:physiology*; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*
chemical_list: D035683:MicroRNAs