title: Vitamin D receptor gene polymorphisms, serum 25-hydroxyvitamin D levels, and melanoma: UK case-control comparisons and a meta-analysis of published VDR data.
abstract: We have carried out melanoma case-control comparisons for six vitamin D receptor (VDR) gene single nucleotide polymorphisms (SNPs) and serum 25-hydroxyvitamin D(3) levels in order to investigate the role of vitamin D in melanoma susceptibility. There was no significant evidence of an association between any VDR SNP and risk in 1028 population-ascertained cases and 402 controls from Leeds, UK. In a second Leeds case-control study (299 cases and 560 controls) the FokI T allele was associated with increased melanoma risk (odds ratio (OR) 1.42, 95% confidence interval (CI) 1.06-1.91, p=0.02). In a meta-analysis in conjunction with published data from other smaller data sets (total 3769 cases and 3636 controls), the FokI T allele was associated with increased melanoma risk (OR 1.19, 95% CI 1.05-1.35), and the BsmI A allele was associated with a reduced risk (OR 0.81, 95% CI 0.72-0.92), in each instance under a parsimonious dominant model. In the first Leeds case-control comparison cases were more likely to have a higher body mass index (BMI) than controls (p=0.007 for linear trend). There was no evidence of a case-control difference in serum 25-hydroxyvitamin D(3) levels. In 1043 incident cases from the first Leeds case-control study, a single estimation of serum 25-hydroxyvitamin D(3) level taken at recruitment was inversely correlated with Breslow thickness (p=0.03 for linear trend). These data provide evidence to support the view that vitamin D and VDR may have a small but potentially important role in melanoma susceptibility, and putatively a greater role in disease progression.
authors.affiliation: Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, University of Leeds, Leeds LS9 7TF, UK.
authors.forename: Juliette A
authors.initials: JA
authors.lastname: Randerson-Moor
authors.forename: John C
authors.initials: JC
authors.lastname: Taylor
authors.forename: Faye
authors.initials: F
authors.lastname: Elliott
authors.forename: Yu-Mei
authors.initials: YM
authors.lastname: Chang
authors.forename: Samantha
authors.initials: S
authors.lastname: Beswick
authors.forename: Kairen
authors.initials: K
authors.lastname: Kukalizch
authors.forename: Paul
authors.initials: P
authors.lastname: Affleck
authors.forename: Susan
authors.initials: S
authors.lastname: Leake
authors.forename: Sue
authors.initials: S
authors.lastname: Haynes
authors.forename: Birute
authors.initials: B
authors.lastname: Karpavicius
authors.forename: Jerry
authors.initials: J
authors.lastname: Marsden
authors.forename: Edwina
authors.initials: E
authors.lastname: Gerry
authors.forename: Linda
authors.initials: L
authors.lastname: Bale
authors.forename: Chandra
authors.initials: C
authors.lastname: Bertram
authors.forename: Helen
authors.initials: H
authors.lastname: Field
authors.forename: Julian H
authors.initials: JH
authors.lastname: Barth
authors.forename: Isabel Dos Santos
authors.initials: Idos S
authors.lastname: Silva
authors.forename: Anthony
authors.initials: A
authors.lastname: Swerdlow
authors.forename: Peter A
authors.initials: PA
authors.lastname: Kanetsky
authors.forename: Jennifer H
authors.initials: JH
authors.lastname: Barrett
authors.forename: D Timothy
authors.initials: DT
authors.lastname: Bishop
authors.forename: Julia A Newton
authors.initials: JA
authors.lastname: Bishop
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D015992:Body Mass Index; D000071616:CDX2 Transcription Factor; D016022:Case-Control Studies; D015252:Deoxyribonucleases, Type II Site-Specific / Q000235:genetics*; D005260:Female; D050980:GATA Transcription Factors / Q000235:genetics; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006200:Hair Color / Q000235:genetics; D018398:Homeodomain Proteins / Q000235:genetics; D006801:Humans; D008297:Male; D008545:Melanoma / Q000097:blood / Q000235:genetics* / Q000473:pathology; D008875:Middle Aged; D009765:Obesity / Q000097:blood; D016133:Polymerase Chain Reaction / Q000379:methods; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D018167:Receptors, Calcitriol / Q000235:genetics*; D013048:Specimen Handling; D013223:Statistics as Topic; D006113:United Kingdom; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D055815:Young Adult
chemical_list: D000071616:CDX2 Transcription Factor; C491270:CDX2 protein, human; D050980:GATA Transcription Factors; D018398:Homeodomain Proteins; D018167:Receptors, Calcitriol; D014807:Vitamin D; C104450:25-hydroxyvitamin D; D015252:Deoxyribonucleases, Type II Site-Specific