title: Preparation and properties of a novel biodegradable polyester elastomer with functional groups.
abstract: A novel biodegradable poly(sebacate-glycerol-citrate) (PGSC) elastomer with functional groups was prepared in this study. First, moldable mixtures were obtained by mixing citric acid with the poly(glycerol-sebacate) (PGS) pre-polymers synthesized in our lab. The PGSC elastomers were obtained from moldable mixtures that were thermally cured in the moulds. Then, the structures, compositions and properties of the elastomers were studied by Fourier transformation infrared spectroscopy (FT-IR), swelling test, differential scanning calorimeter (DSC), tensile test, water contact angle measurement, water absorption experiments and a in vitro degradation test. It showed that the hydroxyl groups remained in the elastomers which would endow the polymer chains with functionality such as good surface modification. By controlling the thermal curing time, the compositions of the PGSC elastomers were adjusted for different mechanical and biodegradable properties. Therefore, PGSC elastomers might be used as anti-conglutination films in surgery, guided tissue regeneration membranes and drug-delivery matrices.
authors.affiliation: Key Laboratory of Beijing City on Preparation and Processing of Novel Polymer Materials, Beijing University of Chemical Technology, Beijing 100029, PR China.
authors.forename: Quan-Yong
authors.initials: QY
authors.lastname: Liu
authors.forename: Si-Zhu
authors.initials: SZ
authors.lastname: Wu
authors.forename: Tian-Wei
authors.initials: TW
authors.lastname: Tan
authors.forename: Jing-Yi
authors.initials: JY
authors.lastname: Weng
authors.forename: Li-Qun
authors.initials: LQ
authors.lastname: Zhang
authors.forename: Li
authors.initials: L
authors.lastname: Liu
authors.forename: Wei
authors.initials: W
authors.lastname: Tian
authors.forename: Da-Fu
authors.initials: DF
authors.lastname: Chen
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D003651:Decanoates / Q000737:chemistry; D020724:Elastomers / Q000737:chemistry*; D005990:Glycerol / Q000031:analogs & derivatives / Q000737:chemistry; D008422:Materials Testing; D008970:Molecular Weight; D011091:Polyesters / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; D003651:Decanoates; D020724:Elastomers; D011091:Polyesters; D011108:Polymers; C469892:poly(glycerol-sebacate); D005990:Glycerol