title: Prevalence and duration of exercise induced albuminuria in healthy people.
abstract: OBJECTIVE
  Vigorous exercise increases urine protein excretion. However, whether exercise increases urine albumin enough to reach the threshold for microalbuminuria (2.8 and 2.0 mg/mmol creatinine in women and men respectively) is uncertain. Furthermore, the duration of such albuminuria is unknown. We aimed to estimate the prevalence and duration of exercise induced microalbuminuria in normal healthy volunteers.
  
  
  METHODS
  Thirty normal subjects provided a urine sample, then exercised to maximal heart rate, or exhaustion, using the standard Bruce Treadmill protocol. Further urine samples were collected within 15 min of completing exercise, and 24 and 48 hr later. Urine creatinine was measured by the Jaffé method and albumin via immunoturbidometry.
  
  
  RESULTS
  Baseline urine albumin: creatinine ratio (A/C) was 0.5 +/- 0.3 (SD) in women (n=14) and 0.4 +/- 0.1 mg/mmol in men (n=16). Immediately after exercise A/C increased to 5.6 +/- 9.7 (in women) and 7.6 +/- 17.6 (in men). Twelve of 30 subjects reached the threshold for microalbuminuria and 2 that for macroalbuminuria. By 24 hr all had returned to baseline and there was no further change at 48 hours.
  
  
  CONCLUSIONS
  A short period, 15-20 min, of maximal exercise leads to A/C ratios above the microalbuminuria threshold in a substantial proportion of normal subjects. Physicians should not measure urine albumin in patients who give a history of such activity in the past 24 hr.
authors.affiliation: Department of Medicine and Cardiovascular Risk Factor Reduction Unit, University of Saskatchewan, SK, Canada.
authors.forename: Karen L
authors.initials: KL
authors.lastname: Heathcote
authors.forename: Merne P
authors.initials: MP
authors.lastname: Wilson
authors.forename: Dale W
authors.initials: DW
authors.lastname: Quest
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Wilson
mesh_terms: D000328:Adult; D000419:Albuminuria / Q000175:diagnosis / Q000209:etiology* / Q000652:urine*; D003404:Creatinine / Q000652:urine; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D015995:Prevalence; D055815:Young Adult
chemical_list: D003404:Creatinine