Uterine leiomyoma is associated with a polymorphism in the interleukin 1-beta gene.
OBJECTIVE
To investigate whether polymorphisms in the interleukin-1beta (IL-1beta) gene are associated with uterine leiomyoma.


METHODS
Case-control study in a collective of 131 patients and 280 controls. Genotyping of the IL-1beta-511 and IL-1beta-3954 polymorphism was performed by PCR amplification and subsequent RFLP analysis.


RESULTS
A significant difference in the allele frequencies of the IL-1beta-511 C<T polymorphism was found. Allele frequencies of the IL-1beta-511 C<T polymorphism were 70.6% (C allele) in the patient group and 57.1% in the control group [P < 0.0002; odds ratio (OR) 1.81; 95% confidence interval (CI): 1.32-2.47]. The genotype distributions showed also differences using a dominant genotype model (C/C vs. C/T+T/T; P < 0.0002; OR 2.73; 95% CI: 1.77-4.2). No difference was found in the IL-1beta-3954 polymorphism.


CONCLUSIONS
The IL-1beta-511 promoter polymorphism is related to an increased susceptibility to uterine leiomyoma, suggesting that this polymorphism does contribute to the development of this disease.
Pietrowski
Detlef
D
Department of Obstetrics and Gynecology, Medical University Vienna, Vienna, Austria. detlef.pietrowski@meduniwien.ac.at
Thewes
Roberta
R
Sator
Michael
M
Denschlag
Dominik
D
Keck
Christoph
C
Tempfer
Clemens
C
D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D053583:Interleukin-1beta / Q000235:genetics*; D007889:Leiomyoma / Q000235:genetics*; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D014594:Uterine Neoplasms / Q000235:genetics*
D053583:Interleukin-1beta