Preparation and properties of a novel biodegradable polyester elastomer with functional groups.
A novel biodegradable poly(sebacate-glycerol-citrate) (PGSC) elastomer with functional groups was prepared in this study. First, moldable mixtures were obtained by mixing citric acid with the poly(glycerol-sebacate) (PGS) pre-polymers synthesized in our lab. The PGSC elastomers were obtained from moldable mixtures that were thermally cured in the moulds. Then, the structures, compositions and properties of the elastomers were studied by Fourier transformation infrared spectroscopy (FT-IR), swelling test, differential scanning calorimeter (DSC), tensile test, water contact angle measurement, water absorption experiments and a in vitro degradation test. It showed that the hydroxyl groups remained in the elastomers which would endow the polymer chains with functionality such as good surface modification. By controlling the thermal curing time, the compositions of the PGSC elastomers were adjusted for different mechanical and biodegradable properties. Therefore, PGSC elastomers might be used as anti-conglutination films in surgery, guided tissue regeneration membranes and drug-delivery matrices.
Liu
Quan-Yong
QY
Key Laboratory of Beijing City on Preparation and Processing of Novel Polymer Materials, Beijing University of Chemical Technology, Beijing 100029, PR China.
Wu
Si-Zhu
SZ
Tan
Tian-Wei
TW
Weng
Jing-Yi
JY
Zhang
Li-Qun
LQ
Liu
Li
L
Tian
Wei
W
Chen
Da-Fu
DF
D001672:Biocompatible Materials / Q000737:chemistry*; D003651:Decanoates / Q000737:chemistry; D020724:Elastomers / Q000737:chemistry*; D005990:Glycerol / Q000031:analogs & derivatives / Q000737:chemistry; D008422:Materials Testing; D008970:Molecular Weight; D011091:Polyesters / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties
D001672:Biocompatible Materials; D003651:Decanoates; D020724:Elastomers; D011091:Polyesters; D011108:Polymers; C469892:poly(glycerol-sebacate); D005990:Glycerol