title: Myeloid-related protein 8/14 levels in children with obstructive sleep apnoea.
abstract: Obstructive sleep apnoea (OSA) is common in children and leads to multiple end-organ morbidities. Myeloid-related protein (MRP) 8/14 plays an important pathophysiological role in atherosclerosis, and plasma levels correlate with endothelial cell dysfunction. We hypothesised that MRP8/14 levels would be altered in children with OSA. 255 children (aged 7.6+/-1.5 yrs) were included after a sleep study and a morning blood sample. MRP8/14 and interleukin-6 plasma levels were assayed using ELISA and C-reactive protein by immunoturbidometry. Endothelial function was assessed as the hyperaemic response after occlusion of the brachial artery. Plasma log MRP8/14 levels showed apnoea/hypopnoea index (AHI) dose-dependent increases regardless of obesity. Moreover, log MRP8/14 levels correlated with log AHI (r = 0.340, p<0.001) after controlling for age and body mass index Z-score, and with endothelial function. Children with the highest MRP levels (>1.34 ug x mL(-1)) had 2.4- and 5.4-fold increased odds of mild OSA and moderate-to-severe OSA, respectively, after adjusting for confounding variables. Plasma MRP8/14 levels are associated with paediatric OSA and may reflect increased risk for cardiovascular morbidity. The short- and long-term consequences of elevated MRP8/14 on cardiovascular function in the context of paediatric OSA remain to be defined.
authors.affiliation: Dept of Paediatrics, University of Chicago, Chicago, IL 60637, USA.
authors.forename: J
authors.initials: J
authors.lastname: Kim
authors.forename: R
authors.initials: R
authors.lastname: Bhattacharjee
authors.forename: A B
authors.initials: AB
authors.lastname: Snow
authors.forename: O S
authors.initials: OS
authors.lastname: Capdevila
authors.forename: L
authors.initials: L
authors.lastname: Kheirandish-Gozal
authors.forename: D
authors.initials: D
authors.lastname: Gozal
mesh_terms: D002097:C-Reactive Protein / Q000378:metabolism; D040501:Calgranulin A / Q000097:blood*; D040502:Calgranulin B / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D004727:Endothelium / Q000502:physiology; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D009017:Morbidity; D009765:Obesity / Q000097:blood; D016017:Odds Ratio; D017286:Polysomnography; D011237:Predictive Value of Tests; D012044:Regression Analysis; D012307:Risk Factors; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology*
chemical_list: D040501:Calgranulin A; D040502:Calgranulin B; C508600:IL6 protein, human; D015850:Interleukin-6; D002097:C-Reactive Protein