title: Effect of age on gingival crevicular fluid concentrations of MIF and PGE2.
abstract: We used an experimental gingivitis study design to compare crevicular fluid concentrations of Migration Inhibitory Factor (MIF) and Prostaglandin E(2) (PGE(2)) in younger (18 to 30 yrs) and older (46 to 77 yrs) healthy adults. PGE(2) increased after 1 wk in younger participants, whereas it decreased in older individuals after 1 wk of plaque accumulation. A significant interaction between age and time was observed for PGE(2) (p = 0.04). High concentrations of MIF were identified in both age groups at baseline. MIF increased in the younger participants, whereas in the older individuals a decrease over time was observed. MIF concentration was positively correlated with plaque index and gingival index in the older age group. Total counts of bacteria, Parvimonas micra and Prevotella intermedia, were significantly correlated with MIF concentration in older participants. In conclusion, MIF and PGE(2) production in response to bacterial accumulation seems to be modified by age.
authors.affiliation: Department of Periodontology, Philipps University, Georg-Voigt-Str. 3, 35033 Marburg, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Nonnenmacher
authors.forename: K
authors.initials: K
authors.lastname: Helms
authors.forename: M
authors.initials: M
authors.lastname: Bacher
authors.forename: R M
authors.initials: RM
authors.lastname: Nüsing
authors.forename: C
authors.initials: C
authors.lastname: Susin
authors.forename: R
authors.initials: R
authors.lastname: Mutters
authors.forename: L
authors.initials: L
authors.lastname: Flores-de-Jacoby
authors.forename: R
authors.initials: R
authors.lastname: Mengel
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D015373:Bacterial Typing Techniques; D003773:Dental Plaque / Q000382:microbiology; D015232:Dinoprostone / Q000032:analysis / Q000378:metabolism*; D005260:Female; D005883:Gingival Crevicular Fluid / Q000737:chemistry*; D005891:Gingivitis / Q000276:immunology* / Q000378:metabolism* / Q000382:microbiology; D006801:Humans; D007111:Immunity, Cellular / Q000502:physiology; D008263:Macrophage Migration-Inhibitory Factors / Q000032:analysis / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010462:Peptostreptococcus / Q000302:isolation & purification; D016133:Polymerase Chain Reaction; D018713:Prevotella intermedia / Q000302:isolation & purification; D055815:Young Adult
chemical_list: D008263:Macrophage Migration-Inhibitory Factors; D015232:Dinoprostone