[Impact of the current antiepileptic drugs on quality of life of epileptic patients].
The purpose of the study was the comparative evaluation of antiepileptic drugs (AED) impact on quality of life (QOL). One hundred and ninety-two patients with symptomatic and probably symptomatic focal epilepsies (mean age 30, 6 +/- 1.05) were investigated. All patients received the following AED as monotherapy: valproate (52), carbamazepine (36), topiramate (56), levitiracetam (24), oxcarbazepine (24). The clinical and neurological examination, EEG and/or video-EEG-monitoring, CT and/ or MRA scan, neuropsychological tests (31-item Quality of Life in Epilepsy--QOLIE-31, version 1 and HUDS) were performed after 3 months of treatment. The higher results of QOL assessment were obtained in the LEV and OXC groups (83.3 and 72%, respectively), the lowest ones--in the CBZ and VPA groups (16.5 and 17%). Clinically relevant emotional disorders occurred more frequently in patients receiving TPM (21.8%), VPA (21.4%) and CBZ (16.6%), significantly rarely in the OXC (8.3%) group and were absent in the LEV group. The strong correlations between QOL, effectiveness, adverse effects and psycho-emotional disorders of AED treatment were found. The best QOL scores were observed in patients treated with newer AED.
Rudakova
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IG
Morozova
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OS
Kotov
A S
AS
D000293:Adolescent; D000328:Adult; D000368:Aged; D000927:Anticonvulsants / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography; D004827:Epilepsy / Q000188:drug therapy / Q000523:psychology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult
D000927:Anticonvulsants