Peroxisome proliferator-activated receptor delta and gastric cancer (Review).
Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily which form heterodimers with retinoid X receptors (RXRs) in nucleus and bind to the PPAR response elements (PPREs) of target genes, leading to a wide spectrum of physiological functions. With an improved understanding of its physiological role, PPARdelta and its agonist have been gaining attention in cancer research in recent years. Despite the paucity of research concerning the direct relationship between PPARdelta and gastric cancer, there is substantial evidence that PPARdelta may play a role in the development of gastric cancer. This review focuses on recent literature describing the role of PPARdelta, especially in its association with nuclear factor-kappaB (NF-kappaB), interleukin-1beta (IL-1beta), cyclooxygenase-2 (COX-2) and Wnt-beta-catenin/TCF-4 pathways on gastric tumorigenesis and highlights critical discrepancies that need to be resolved for a more comprehensive understanding of how this receptor modulates gastric tumorigenesis. The potential role of PPARdelta as a therapeutic target in the treatment of gastric cancer deserves further research focus.
Wu
Chung W
CW
Department of Medicine and Therapeutics, Prince of Wales Hospital, Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, PR China.
Yu
Jun
J
Sung
Joseph J Y
JJ
D000818:Animals; D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; D051546:Cyclooxygenase 2 / Q000502:physiology; D004268:DNA-Binding Proteins / Q000502:physiology; D006801:Humans; D053583:Interleukin-1beta / Q000502:physiology; D016328:NF-kappa B / Q000502:physiology; D047494:PPAR delta / Q000502:physiology*; D013274:Stomach Neoplasms / Q000209:etiology*; D000073940:Transcription Factor 4; D014157:Transcription Factors / Q000502:physiology; D051153:Wnt Proteins / Q000502:physiology
D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; D004268:DNA-Binding Proteins; D053583:Interleukin-1beta; D016328:NF-kappa B; D047494:PPAR delta; C532096:TCF4 protein, human; D000073940:Transcription Factor 4; D014157:Transcription Factors; D051153:Wnt Proteins; D051546:Cyclooxygenase 2