Repetitive oocyte donation does not decrease serum anti-Müllerian hormone levels.
OBJECTIVE
To determine if the anti-Müllerian hormone (AMH), a proposed marker of ovarian aging, decreases with repetitive oocyte donation.


METHODS
Retrospective cohort.


METHODS
Academic.


METHODS
Thirty-six young women who underwent three to seven oocyte donation cycles.


METHODS
Assessor blind determination of AMH levels from serum samples collected during each treatment cycle.


METHODS
Cycle trends of serum AMH levels.


RESULTS
The AMH was the only predictor of oocyte yield in the first cycles. The AMH was negatively associated with donor age and follicle stimulating hormone (FSH) dose used. Serum AMH levels did not show any decrease per treatment cycle basis and per maximum number of oocyte donation cycles performed per woman. Whereas donors who underwent six cycles showed increasing AMH levels when controlled for studied covariates, the slopes of the multiple regression curves were not significantly different from donors who underwent three, four, and five cycles. Clinical outcome assessed by FSH dose/number of oocytes ratio did not show significant change over repetitive cycles. Intercycle variation of AMH in all patients over three cycles was found to be 12.5%, which was within the reported intermenstrual range.


CONCLUSIONS
Serum AMH levels do not decrease over repetitive oocyte donation cycles, which may imply that accelerated ovarian aging may not occur in oocyte donors.
Bukulmez
Orhan
O
Department of Obstetrics and Gynecology, University of Florida College of Medicine, Gainesville, Florida 32610-0294, USA. obukulmez@ufl.edu
Li
Qin
Q
Carr
Bruce R
BR
Leader
Benjamin
B
Doody
Kathleen M
KM
Doody
Kevin J
KJ
D000328:Adult; D054304:Anti-Mullerian Hormone / Q000032:analysis / Q000097:blood* / Q000502:physiology; D015415:Biomarkers / Q000032:analysis / Q000097:blood; D002452:Cell Count; D015536:Down-Regulation; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D018587:Oocyte Donation / Q000009:adverse effects* / Q000379:methods; D009865:Oocytes / Q000166:cytology; D010062:Ovulation Induction / Q000379:methods; D010507:Periodicity; D011247:Pregnancy; D018873:Pregnancy Rate; D011258:Pregnancy Tests; D012189:Retrospective Studies; D055815:Young Adult
D015415:Biomarkers; D054304:Anti-Mullerian Hormone