Reductions in paradoxical sleep time in adult rats treated neonatally with low dose domoic acid.
One hallmark of neurological dysfunction is a reduction in paradoxical sleep (PS) time. To determine if adult rats treated neonatally with low dose domoic acid have altered sleep patterns, a home cage analysis of electroencephalogram (EEG) waveforms was performed using radio telemetry. Domoate treated rats spent significantly less time in PS than controls during daytime hours even though they spent the same total amount of time sleeping, and showed no difference in stage shifts into the PS stage.
Gill
D A
DA
Department of Biomedical Sciences, University of Prince Edward Island, 550 University Avenue, Charlottetown, PE, Canada.
Bastlund
J F
JF
Anderson
N J
NJ
Tasker
R A
RA
D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000187:drug effects / Q000503:physiopathology; D004567:Electrodes, Implanted; D004569:Electroencephalography; D004576:Electromyography; D007608:Kainic Acid / Q000031:analogs & derivatives* / Q000633:toxicity; D008297:Male; D009498:Neurotoxins / Q000633:toxicity*; D017440:Photoperiod; D051381:Rats; D017207:Rats, Sprague-Dawley; D012894:Sleep Stages / Q000187:drug effects / Q000502:physiology; D012893:Sleep Wake Disorders / Q000139:chemically induced* / Q000503:physiopathology; D012895:Sleep, REM / Q000187:drug effects* / Q000502:physiology; D013686:Telemetry; D013997:Time Factors
D009498:Neurotoxins; C012301:domoic acid; D007608:Kainic Acid