Diagnostic test validation: cochlear hydrops analysis masking procedure in Ménière's disease.
OBJECTIVE
To determine the diagnostic value of the cochlear hydrops analysis masking procedure (CHAMP) in patients with definite Ménière's disease.


METHODS
Prospective validation study for a diagnostic test, study phase 2.


METHODS
Tertiary referral centers.


METHODS
Subjects with definite Ménière's disease (Group 1), differential diagnosis (Group 2: another audiovestibular diseases or neurologic disorders), and normal hearing (Group 3) were included. Sample sizes were calculated.


METHODS
Study test (CHAMP) was compared with the current clinical criterion standard described by the guidelines of the American Academy of Otolaryngology-Head and Neck Surgery.


METHODS
Sensitivity, specificity, and other indicators of diagnostic validation.


RESULTS
One hundred ten cases completed the follow-up, and their results are presented. Sensitivity at 31.3% and specificity at 100% were found in subjects with definite Ménière's disease, features that are more helpful in confirming the diagnosis than in rejecting it. Group 1 showed significantly shorter latency delays than Groups 2 and 3 (p < 0.001).


CONCLUSIONS
If definite Ménière's disease is suspected, an abnormal result confirms the diagnosis; however, a normal result does not rule out the Ménière's disease diagnosis.
Ordóñez-Ordóñez
Leonardo Elías
LE
Universidad Militar Nueva Granada, Otolaryngology Department, Hospital Universitario Clínica San Rafael, Bogotá, Colombia. otoleor@gmail.com
Rojas-Roncancio
Eveling
E
Hernández-Alarcón
Víctor
V
Jaramillo-Safón
Rafael
R
Prieto-Rivera
Jose
J
Guzmán-Durán
Jose
J
Lora-Falquez
Jose
J
Escobar
Marcela
M
Angulo-Martínez
Esther Sofía
ES
D000328:Adult; D001299:Audiometry; D015834:Cochlear Diseases / Q000175:diagnosis*; D003937:Diagnosis, Differential; D004487:Edema / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008297:Male; D008575:Meniere Disease / Q000175:diagnosis*; D008875:Middle Aged; D011446:Prospective Studies; D012015:Reference Standards; D015203:Reproducibility of Results; D018401:Sample Size