Cognitive training in affective disorders improves memory: a preliminary study using the NEAR approach.
BACKGROUND
Neuropsychological deficits in depression include difficulties with psychomotor speed, executive functions and memory. Some of these changes persist despite antidepressant treatment. While research in other areas of psychiatry has shown cognitive training techniques to be effective, only one study has evaluated this approach in depression.


METHODS
Sixteen patients (mean age=33.5years) with a lifetime diagnosis of major depressive disorder were administered a standardised battery of neuropsychological tests and allocated to treatment (n=8) or waitlist control (n=8) conditions. The treatment consisted of 10-weeks of twice weekly cognitive training using the Neuropsychological Educational Approach to Remediation. All participants were re-assessed after 10-weeks by interviewers blinded to group allocation.


RESULTS
Participants in the treatment condition demonstrated greater improvements on tests of memory encoding and memory retention than the waitlist control group. There were no observable benefits in terms of psychomotor speed or executive functions or in self-reported levels of disability. Affective symptoms also remained stable.


CONCLUSIONS
This study included a small sample of participants and treatment allocation was not randomised.


CONCLUSIONS
Cognitive training in affective disorders improves memory performance. It may be an effective non-pharmacological treatment option for improving cognitive functions, which in turn, may improve psychosocial functioning and reduce disability. This study supports theories suggesting cognitive training may promote neuroplasticity.
Naismith
Sharon L
SL
Clinical Research Unit, Brain & Mind Research Institute, University of Sydney, NSW, Australia. snaismith@med.usyd.edu.au
Redoblado-Hodge
M Antoinette
MA
Lewis
Simon J G
SJ
Scott
Elizabeth M
EM
Hickie
Ian B
IB
D000328:Adult; D003072:Cognition Disorders / Q000175:diagnosis / Q000523:psychology / Q000628:therapy*; D003131:Combined Modality Therapy; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000523:psychology / Q000628:therapy*; D056344:Executive Function; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D011939:Mental Recall; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000706:statistics & numerical data*; D010555:Personality Inventory / Q000706:statistics & numerical data; D011594:Psychometrics; D011597:Psychomotor Performance; D011619:Psychotropic Drugs / Q000627:therapeutic use; D011930:Reaction Time; D012073:Remedial Teaching; D012153:Retention, Psychology; D016896:Treatment Outcome
D011619:Psychotropic Drugs