title: Electrospray ionization tandem mass spectrometric characteristics of d4T H-phosphonate and distamycin conjugates.
abstract: The study of the dissociation of the protonated molecular species [M+H](+) and selected fragment ions allowed proposals for the main fragmentation pathways of the title compounds. The main fragments are formed by expelling a molecule of thymine, thymidine (d4T) or isopropyl. The most striking feature of the tandem mass (MS/MS) spectra is the cleavage of C-CO bonds between N-methylpyrrole and carbonyl groups in the presence of the amidine. Electrospray ionization is proven to be a good method for the structural characterization and identification of these kinds of compounds.
authors.affiliation: State Laboratory of Chemical Resource Engineering, Department of Pharmaceutical Engineering, Beijing University of Chemical Technology, Beijing, China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Ding
authors.forename: Ning
authors.initials: N
authors.lastname: Qian
authors.forename: Chao
authors.initials: C
authors.lastname: Li
authors.forename: Renzhong
authors.initials: R
authors.lastname: Qiao
authors.forename: Yufen
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry*; D004214:Distamycins / Q000737:chemistry*; D015394:Molecular Structure; D063065:Organophosphonates / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods; D018119:Stavudine / Q000737:chemistry*; D053719:Tandem Mass Spectrometry / Q000379:methods*
chemical_list: D019380:Anti-HIV Agents; D004214:Distamycins; D063065:Organophosphonates; C030000:stallimycin; D018119:Stavudine