Reactive oxygen species-dependent signaling regulates cancer.
Historically, it has been assumed that oxidative stress contributes to tumor initiation and progression solely by inducing genomic instability. Recent studies indicate that reactive oxygen species are upregulated in tumors and can lead to aberrant induction of signaling networks that cause tumorigenesis and metastasis. Here we review the role of redox-dependent signaling pathways and transcription factors that regulate tumorigenesis.
Weinberg
Frank
F
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Medical School, Chicago, IL 60611, USA.
Chandel
Navdeep S
NS
D049109:Cell Proliferation; D004249:DNA Damage; D042822:Genomic Instability; D006801:Humans; D024101:Mitochondrial Proteins / Q000235:genetics; D008954:Models, Biological; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism; D009857:Oncogenes / Q000502:physiology; D010084:Oxidation-Reduction; D017382:Reactive Oxygen Species / Q000378:metabolism*; D015398:Signal Transduction; D014157:Transcription Factors / Q000502:physiology
D024101:Mitochondrial Proteins; D017382:Reactive Oxygen Species; D014157:Transcription Factors