Prolonged-release naloxone can cause systemic opioid withdrawal.
Wilcock
Andrew
A
D000701:Analgesics, Opioid / Q000009:adverse effects; D003692:Delayed-Action Preparations / Q000009:adverse effects*; D003967:Diarrhea / Q000139:chemically induced; D004305:Dose-Response Relationship, Drug; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D009270:Naloxone / Q000008:administration & dosage* / Q000009:adverse effects*; D009292:Narcotic Antagonists / Q000008:administration & dosage* / Q000009:adverse effects*; D009293:Opioid-Related Disorders / Q000188:drug therapy; D010098:Oxycodone / Q000037:antagonists & inhibitors; D010349:Patient Compliance / Q000706:statistics & numerical data; D010818:Practice Patterns, Physicians' / Q000639:trends; D013375:Substance Withdrawal Syndrome / Q000209:etiology* / Q000503:physiopathology*
D000701:Analgesics, Opioid; D003692:Delayed-Action Preparations; D009292:Narcotic Antagonists; D009270:Naloxone; D010098:Oxycodone