title: Bone marrow large B cell lymphoma bearing cyclin D3 expression: clinical, morphologic, immunophenotypic, and genotypic analyses of seven patients.
abstract: We report seven large B cell lymphoma patients showing the involvement of tumor cells with cyclin D3 (CCND3) expression in bone marrow (BM) at the initial diagnosis. All patients presented with B symptoms, splenomegaly, and anemia/thrombocytopenia lacking hemophagocytosis in the BM. Five of the seven patients had suffered from immunological diseases or cancers. The tumor cells were divided into those with a lymphoplasmacytoid or blastoid appearance. Six cases were confirmed to express CD5 antigen on tumor cells. Three cases presented a chromosomal translocation between CCND3 and the immunoglobulin heavy chain (IGH) loci, t(6;14)(p21;q32). Three and two cases showed unmutated and mutated sequences of the variable region of IGH (VH), respectively, and one case showed deletion of an entire segment of VH. Two cases with t(6;14)(p21;q32) showed an unmutated VH sequence and chromosomal translocation within the switch region of IGH. Further studies are required to determine whether CCND3 expression is associated with a unique subset of diffuse large B cell lymphoma.
authors.affiliation: Department of Hematology/Oncology, Wakayama Medical University, Kimi-idera 811-1, Wakayama, 641-8510, Japan.
authors.forename: Jyuri
authors.initials: J
authors.lastname: Watanuki
authors.affiliation: Department of Pathology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
authors.forename: Kinta
authors.initials: K
authors.lastname: Hatakeyama
authors.affiliation: Department of Hematology/Oncology, Wakayama Medical University, Kimi-idera 811-1, Wakayama, 641-8510, Japan. sonoki@wakayama-med.ac.jp.
authors.forename: Takashi
authors.initials: T
authors.lastname: Sonoki
authors.affiliation: Department of Hematology, Kumamoto University School of Medicine, Kumamoto, Japan.
authors.forename: Hiro
authors.initials: H
authors.lastname: Tatetsu
authors.affiliation: Department of Hematology, Saitama Medical University, Saitama, Japan.
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Yoshida
authors.affiliation: Department of Internal Medicine, Okayama Red Cross General Hospital, Okayama, Japan.
authors.forename: Soichiro
authors.initials: S
authors.lastname: Fujii
authors.affiliation: Department of Internal Medicine, Matsusaka Chuo General Hospital, Matsusaka, Japan.
authors.forename: Minoru
authors.initials: M
authors.lastname: Mizutani
authors.affiliation: Department of Laboratory Medicine, Iwate Medical University, Morioka, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Abo
authors.affiliation: Department of Hematology/Oncology, Wakayama Medical University, Kimi-idera 811-1, Wakayama, 641-8510, Japan.
authors.forename: Miwa
authors.initials: M
authors.lastname: Kurimoto
authors.affiliation: Department of Hematology/Oncology, Wakayama Medical University, Kimi-idera 811-1, Wakayama, 641-8510, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Matsuoka
authors.affiliation: Department of Hematology, Kumamoto University School of Medicine, Kumamoto, Japan.
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Matsuno
authors.affiliation: Department of Hematology/Oncology, Wakayama Medical University, Kimi-idera 811-1, Wakayama, 641-8510, Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Nakakuma
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001402:B-Lymphocytes / Q000473:pathology / Q000502:physiology*; D001854:Bone Marrow Cells / Q000473:pathology / Q000502:physiology*; D056743:Cyclin D3; D016213:Cyclins / Q000235:genetics*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D005838:Genotype; D006801:Humans; D007134:Immunoglobulin Switch Region / Q000235:genetics; D016130:Immunophenotyping; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic
chemical_list: C534696:CCND3 protein, human; D056743:Cyclin D3; D016213:Cyclins