Selective identification of cooperatively binding fragments in a high-throughput ligation assay enables development of a picomolar caspase-3 inhibitor.
Schmidt
Marco F
MF
Leibniz Institute of Molecular Pharmacology (FMP), Robert-Rössle-Strasse 10, 13125 Berlin, Germany.
El-Dahshan
Adeeb
A
Keller
Sandro
S
Rademann
Jörg
J
D000447:Aldehydes / Q000737:chemistry* / Q000494:pharmacology; D053148:Caspase 3 / Q000378:metabolism; D061945:Caspase Inhibitors; D015853:Cysteine Proteinase Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D005454:Fluorescence Polarization; D011485:Protein Binding
D000447:Aldehydes; D061945:Caspase Inhibitors; D015853:Cysteine Proteinase Inhibitors; D053148:Caspase 3