title: Hyperkalemia and cocaine induced dynamic Brugada-type electrocardiogram.
abstract: Brugada syndrome is a well-defined clinical entity with the typical electrocardiographic changes in the right precordial leads (V1 and V2), attributed to mutation in SCN5A gene. Brugada-like electrocardiographic pattern can be replicated by sodium channel-blocking drugs and electrolyte abnormalities. We describe a 46-year-old individual, who presented with hyperkalemia secondary to muscle damage and renal insufficiency, after abusing cocaine. The electrocardiogram showed Brugada sign. The electrocardiogram changes disappeared after sodium bicarbonate administration and normalization of serum potassium. The case highlights the importance of recognizing cocaine and hyperkalemia, as potential triggers of the acquired Brugada sign.
authors.affiliation: Department of Internal Medicine, St. Vincent Mercy Medical Center, University of Toledo Medical Center, Toledo, Ohio 43608, USA. farzan_i@yahoo.com
authors.forename: Farzan
authors.initials: F
authors.lastname: Irani
authors.forename: Rahil
authors.initials: R
authors.lastname: Kasmani
authors.forename: Yousuf
authors.initials: Y
authors.lastname: Kanjwal
mesh_terms: D053840:Brugada Syndrome / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D003042:Cocaine / Q000009:adverse effects*; D018765:Dopamine Uptake Inhibitors / Q000009:adverse effects*; D004562:Electrocardiography; D006801:Humans; D006947:Hyperkalemia / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged
chemical_list: D018765:Dopamine Uptake Inhibitors; D003042:Cocaine