title: [Outcome of surgical treatment of liver metastasis from colorectal cancer].
abstract: BACKGROUND
  Surgical resection is the only treatment associated with long-term cure in patients with liver metastasis from colorectal cancer, achieving a 30% to 40% five years survival.
  
  
  OBJECTIVE
  To evaluate the results of liver resection for metastatic colorectal cancer in our centre.
  
  
  METHODS
  Retrospective study. Epidemiological, perioperative and follow up data of patients undergoing liver resection for metastatic colorectal cancer between January 1990 and July 2007 were assessed. We compared the results between two periods; period 1 (1990-1997) and period 2 (1998-2007).
  
  
  RESULTS
  Sixty six patients aged 61+/- 12 years (46 males) underwent 75 resections. An anatomical excision was performed in 54 (72%) cases, a right hepatectomy in 18, an extended right hepatectomy in 11, a left hepatectomy in 1, and a segmentectomy in 24. In 24 (32%) patients the liver resection was simultaneous with the colorectal cancer resection. Operative time was 221+/-86 min. Hospital stay was 11+/-5 days. Postoperative morbidity was 35% and surgical mortality was 0%. Resection margin was free of tumor in 53 (80%) patients. Five years overall and hepatic disease-free survival was 38% and 23%, respectively. In period 2, more anatomical resections than in period 1 were performed (77% and 55%, respectively, p =0.04), without an increase in complications (35% and 34%, respectively; p =ns), but with a better five years survival (45% and 21 %, respectively, p =0.04).
  
  
  CONCLUSIONS
  Five years survival for excision of liver metastatic colorectal cancer in our center is similar to that reported abroad. During the second period there has been a trend toward more extensive resections which was associated with a better survival, without an increase in complications or mortality .
authors.affiliation: Departamento de Cirugía Digestiva, División de Cirugía, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
authors.forename: Enrique
authors.initials: E
authors.lastname: Norero
authors.forename: Nicolás
authors.initials: N
authors.lastname: Jarufe
authors.forename: Jean M
authors.initials: JM
authors.lastname: Butte
authors.forename: Blanca
authors.initials: B
authors.lastname: Norero
authors.forename: Ignacio
authors.initials: I
authors.lastname: Duarte
authors.forename: Javiera
authors.initials: J
authors.lastname: Torres
authors.forename: George
authors.initials: G
authors.lastname: Pinedo
authors.forename: Francisco
authors.initials: F
authors.lastname: López
authors.forename: Juan Francisco
authors.initials: JF
authors.lastname: Guerra
authors.forename: Luis
authors.initials: L
authors.lastname: Ibáñez
authors.forename: Alvaro
authors.initials: A
authors.lastname: Zúñiga
authors.forename: Sergio
authors.initials: S
authors.lastname: Guzmán
authors.forename: Jorge
authors.initials: J
authors.lastname: Martínez
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000473:pathology*; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D055815:Young Adult