[Churg-Strauss syndrome presenting as polymyositis: report of a case].
We reported the case of a male patient with Churg-Strauss syndrome (CSS) heralding as symptoms typical of polymiositis. During high-dose cortisone therapy (1.5 mg/kg/day), he developed a severe multiplex mononeuritis, poorly responsive to immunoglobulins and methotrexate administration. After 6 months he developed a partial deficiency of the right sciatic popliteus and the radial nerves. Sural nerve biopsy showed a characteristic necrotizing vasculitis of the epineural vessels with granulocyte and eosinophil infiltrates. In the course of CSS, peripheral nervous system involvement is frequent and can lead to disability. For this reason, it must be promptly recognized and properly treated.
Lazzarin
P
P
Ambulatorio di Reumatologia, Ospedale di Este, Padova, Italia. plazzarin@libero.it
Presotto
F
F
Polo
A
A
D015267:Churg-Strauss Syndrome / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000534:rehabilitation; D003348:Cortisone / Q000008:administration & dosage / Q000009:adverse effects; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D006801:Humans; D007136:Immunoglobulins / Q000008:administration & dosage / Q000009:adverse effects; D007155:Immunologic Factors / Q000008:administration & dosage / Q000009:adverse effects; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D017285:Polymyositis / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000534:rehabilitation; D016896:Treatment Outcome
D007136:Immunoglobulins; D007155:Immunologic Factors; D007166:Immunosuppressive Agents; D003348:Cortisone