title: Prognostic significance of new immunohistochemical markers in refractory classical Hodgkin lymphoma: a study of 59 cases.
abstract: Although most classical Hodgkin lymphoma patients are cured, a significant minority fail after primary therapy and may die as result of their disease. To date, there is no consensus on biological markers that add value to usual parameters (which comprise the International Prognostic Score) used at diagnosis to predict outcome. We evaluated 59 patients (18 with primary refractory or early relapse disease and 41 responders) for bcl2, Ki67, CD20, TiA1 and c-kit expression by semi-quantitative immunohistochemical study and correlated the results with the response to treatment.The results showed that expression of bcl2 and CD20 in Hodgkin and Reed Sternberg cells, and expression of TiA1 in micro-environmental lymphocytes, and c-kit positive mast cells in microenvironment, were independent prognostic markers. These novel cHL markers could be used in association with clinical parameters to identify newly diagnosed patients with favorable or unfavorable prognosis and to better tailor treatment for different risk groups.
authors.affiliation: Department of Pathology, Necker Hospital, Assistance Publique-Hôpitaux de Paris, University Paris-Descartes, Faculté de Médecine, Paris, France. danielle.canioni@nck.aphp.fr
authors.forename: Danielle
authors.initials: D
authors.lastname: Canioni
authors.forename: Bénédicte
authors.initials: B
authors.lastname: Deau-Fischer
authors.forename: Pierre
authors.initials: P
authors.lastname: Taupin
authors.forename: Vincent
authors.initials: V
authors.lastname: Ribrag
authors.forename: Richard
authors.initials: R
authors.lastname: Delarue
authors.forename: Jacques
authors.initials: J
authors.lastname: Bosq
authors.forename: Marie-Thérèse
authors.initials: MT
authors.lastname: Rubio
authors.forename: Damien
authors.initials: D
authors.lastname: Roux
authors.forename: Viorel
authors.initials: V
authors.lastname: Vasiliu
authors.forename: Bruno
authors.initials: B
authors.lastname: Varet
authors.forename: Nicole
authors.initials: N
authors.lastname: Brousse
authors.forename: Olivier
authors.initials: O
authors.lastname: Hermine
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism*; D005260:Female; D006689:Hodgkin Disease / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor