Saponins as novel TNF-alpha inhibitors: isolation of saponins and a nor-pseudoguaianolide from Parthenium hysterophorus.
Two novel saponins and a 13-nor-pseudoguaianolide designated as hysterolactone were isolated from Parthenium hysterophorus. The two saponins were found to be potent inhibitors of TNF-alpha. Their mode of inhibition was studied through molecular modeling. The wet lab results were in concordance with the data obtained from docking experiments.
Shah
Bhahwal Ali
BA
Bio-organic Chemistry Division, Indian Institute of Integrative Medicine (IIIM), Canal Road, Jammu Tawi-180001, India. bashah@iiim.res.in
Chib
Renu
R
Gupta
Pankaj
P
Sethi
Vijay Kumar
VK
Koul
Surrinder
S
Andotra
Samar Singh
SS
Nargotra
Amit
A
Sharma
Sujata
S
Pandey
Anjali
A
Bani
Sarang
S
Purnima
Basant
B
Taneja
Subhash Chandra
SC
D019659:Asteraceae / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry*; D012503:Saponins / Q000302:isolation & purification*; D045789:Sesquiterpenes, Guaiane / Q000302:isolation & purification*; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors*
C546815:13-nor-pseudoguaianolide; D010936:Plant Extracts; D012503:Saponins; D045789:Sesquiterpenes, Guaiane; D014409:Tumor Necrosis Factor-alpha