Cystic fibrosis, common variable immunodeficiency and Aspergers syndrome: an immunological and behavioural challenge.
BACKGROUND
Cystic fibrosis (CF) is of particular importance in Ireland as the Irish population has both the highest incidence (2.98/10,000) and the highest carrier rate (1 in 19) in the world. Primary immunodeficiency has not been previously reported as co-existing with CF.


METHODS
We report a unique case of CF associated with a primary immunodeficiency syndrome--common variable immunodeficiency (CVID).


CONCLUSIONS
Our patient has CF, CVID and the additional comorbidity of Aspergers syndrome. The challenges inherent in diagnosing and treating such a case are outlined herein and the successful management of this case is evidenced by the well-preserved lung function of our patient.
Chotirmall
S H
SH
Respiratory Research Division, Department of Medicine, Education and Research Centre, Royal College of Surgeons in Ireland, Beaumont Hospital, Beaumont Road, Dublin 9, Republic of Ireland. schotirmall@rcsi.ie
Low
T B
TB
Hassan
T
T
Branagan
P
P
Kernekamp
C
C
Flynn
M G
MG
Gunaratnam
C
C
McElvaney
N G
NG
D000328:Adult; D020817:Asperger Syndrome / Q000150:complications* / Q000523:psychology; D017074:Common Variable Immunodeficiency / Q000150:complications* / Q000175:diagnosis; D003550:Cystic Fibrosis / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D008297:Male; D010349:Patient Compliance / Q000523:psychology; D055815:Young Adult