title: Using LongSAGE to Detect Biomarkers of Cervical Cancer Potentially Amenable to Optical Contrast Agent Labelling.
abstract: Sixteen longSAGE libraries from four different clinical stages of cervical intraepithelial neoplasia have enabled us to identify novel cell-surface biomarkers indicative of CIN stage. By comparing gene expression profiles of cervical tissue at early and advanced stages of CIN, several genes are identified to be novel genetic markers. We present fifty-six cell-surface gene products differentially expressed during progression of CIN. These cell surface proteins are being examined to establish their capacity for optical contrast agent binding. Contrast agent visualization will allow real-time assessment of the physiological state of the disease process bringing vast benefit to cancer care. The data discussed in this publication have been submitted to NCBIs Gene Expression Omnibus (GEO, http://www.ncbi.nlm.nih.gov/geo/) and are accessible through GEO Series accession number GSE6252.
authors: Genome Sciences Centre, British Columbia Cancer Research Centre, Vancouver, BC, Canada.
authors: Julie M
authors: JM
authors: Kneller
authors: Thomas
authors: T
authors: Ehlen
authors: Jasenka P
authors: JP
authors: Matisic
authors: Dianne
authors: D
authors: Miller
authors: Dirk
authors: D
authors: Van Niekerk
authors: Wan L
authors: WL
authors: Lam
authors: Marco
authors: M
authors: Marra
authors: Rebecca
authors: R
authors: Richards-Kortum
authors: Michelle
authors: M
authors: Follen
authors: Calum
authors: C
authors: Macaulay
authors: Steven J M
authors: SJ
authors: Jones