[Endothelial dysfunction and oxygen binding properties of hemoglobin].
According to results of analysis of literature and carried out studies endothelial dysfunction is associated with impaired formation of NO-derivatives of hemoglobin. This affects not only NO release in various parts of vascular bed but also affinity of hemoglobin to oxygen, and therefore optimal course of blood oxygenation/deoxygenation in capillaries of pulmonary and systemic circulation. Formation of endothelial dysfunction leads to changes of oxygen binding properties of blood, origination of hypoxia, and augmentation of manifestations of endothelial dysfunction. Efficacy of differentiated application of traditional drug therapy with consideration of dysfunction of endothelium by means of targeted influence on oxygen binding properties of blood and L-arginine - NO system is discussed.
Zinchuk
V V
VV
D004730:Endothelium, Vascular / Q000378:metabolism / Q000503:physiopathology*; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D000860:Hypoxia / Q000097:blood* / Q000503:physiopathology; D018384:Oxidative Stress / Q000502:physiology*; D010100:Oxygen / Q000097:blood*; D010101:Oxygen Consumption / Q000502:physiology*
D006454:Hemoglobins; D010100:Oxygen