No association between phosphatase and tensin homolog genetic polymorphisms and colon cancer.
OBJECTIVE
To investigate the association between single nucleotide polymorphisms (SNPs) in the phosphatase and tensin homolog (PTEN) tumor suppressor gene and risk of colon cancer.


METHODS
We utilized a population-based case-control study of incident colon cancer individuals (n = 421) and controls (n = 483) aged > or = 30 years to conduct a comprehensive tagSNP association analysis of the PTEN gene.


RESULTS
None of the PTEN SNPs were statistically significantly associated with colon cancer when controlled for age, gender, and race, or when additionally adjusted for other known risk factors (P > 0.05). Haplotype analyses similarly showed no association between the PTEN gene and colon cancer.


CONCLUSIONS
Our study does not support PTEN as a colon cancer susceptibility gene.
Phillips
Lynette S
LS
Department of Epidemiology and Biostatistics and Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106-7136, United States.
Thompson
Cheryl L
CL
Merkulova
Alona
A
Plummer
Sarah J
SJ
Tucker
Thomas C
TC
Casey
Graham
G
Li
Li
L
D003110:Colonic Neoplasms / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D051059:PTEN Phosphohydrolase / Q000235:genetics* / Q000378:metabolism; D011110:Polymorphism, Genetic
D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human