[The model specification of the period without recurrences in rats after Pliss lymphosarcoma resection].
The purpose of the present study was to make an experimental model of the period without recurrences in rats after Pliss lymphosarcoma (PLS) resection. Experiments were carried out on white low-bred male rats (n=109). For the tumor transinoculation the rats received subcutaneously 0.2 ml of the aseptic 50% suspension of PLS prepared according to the standards on saline without antibiotic addition. The injections were done in the right abdomen region. The animals were classified into three groups. Group 1 was used for control. An operation of lymphosarcoma resection was carried out on the rats from group 2 on the fifth day from the tumor inoculation. The tumor in the animals from group 3 was dissected on 12-22nd day from its inoculation. At the same time the specification of the duration of the period without recurrences was estimated in every group. According to the suggested method the Pliss lymphosarcoma resection significantly increases the life duration of operated rats that proves the efficiency of surgical interventions. The absence of intraoperative and postoperative lethality on the fifth day from the Pliss lymphosarcoma resection and 100% animal death resulting from the recurrences makes the proposed model potentially suitable for the investigation of adjuvant methods that are used in the treatment of cancer.
Samsoniia
M D
MD
Lesnovskaia
E E
EE
Gibradze
O T
OT
Kandelaki
M A
MA
D000818:Animals; D017024:Chemotherapy, Adjuvant; D004195:Disease Models, Animal; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery*; D008297:Male; D009364:Neoplasm Recurrence, Local; D051381:Rats; D023041:Xenograft Model Antitumor Assays