Metastasis-promoting immunity: when T cells turn to the dark side.
While the role of endogenous T cells in antitumor immunity is being debated, little is known about whether and how T cells promote tumorigenesis. In this issue of Cancer Cell, DeNardo and colleagues demonstrate that IL-4-producing T cells enhance metastasis by programming macrophages to produce factors that enhance tumor invasion.
Pardoll
Drew
D
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA. dpardol1@jhmi.edu
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000502:physiology*; D004195:Disease Models, Animal; D005260:Female; D015847:Interleukin-4 / Q000378:metabolism* / Q000502:physiology; D008175:Lung Neoplasms / Q000276:immunology / Q000556:secondary*; D008213:Lymphocyte Activation; D008264:Macrophages / Q000378:metabolism* / Q000502:physiology; D008325:Mammary Neoplasms, Experimental / Q000276:immunology / Q000473:pathology*; D051379:Mice; D018448:Models, Immunological; D015398:Signal Transduction
D015847:Interleukin-4