title: 2,6,8-Trisubstituted 3-hydroxychromone derivatives as fluorophores for live-cell imaging.
abstract: We present the synthesis and photophysical characterisation of a series of structurally diverse, fluorescent 2,6,8-trisubstituted 3-hydroxychromone derivatives with high fluorescence quantum yields and molar extinction coefficients. Two of these derivatives (9 and 10 a) have been studied as fluorophores for cellular imaging in HeLa cells and show excellent permeability and promising fluorescence properties in a cellular environment. In addition, we have demonstrated by photophysical characterisation of 3-isobutyroxychromone derivatives that esterification of the 3-hydroxyl group results in acceptable and useful fluorescence properties.
authors: Department of Chemistry-Medicinal Chemistry, University of Gothenburg, 412 96 Göteborg, Sweden.
authors: Christine
authors: C
authors: Dyrager
authors: Annika
authors: A
authors: Friberg
authors: Kristian
authors: K
authors: Dahlén
authors: Maria
authors: M
authors: Fridén-Saxin
authors: Karl
authors: K
authors: Börjesson
authors: L Marcus
authors: LM
authors: Wilhelmsson
authors: Maria
authors: M
authors: Smedh
authors: Morten
authors: M
authors: Grøtli
authors: Kristina
authors: K
authors: Luthman
mesh_terms: D002867:Chromones / Q000138:chemical synthesis / Q000737:chemistry*; D005434:Flow Cytometry; D005456:Fluorescent Dyes / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D008856:Microscopy, Fluorescence; D010777:Photochemistry
chemical_list: C479534:3-hydroxychromone; D002867:Chromones; D005456:Fluorescent Dyes