Nidogen plays a role in the regenerative axon growth of adult sensory neurons through Schwann cells.
We previously reported that nidogen is an extracellular matrix protein regulating Schwann cell proliferation and migration. Since Schwann cells play a critical role in peripheral nerve regeneration, nidogen may play a role in it via regulation of Schwann cells. Here, we demonstrate direct evidence that nidogen induces elongation of regenerative axon growth of adult sensory neurons, and that the effect is Schwann cell dependent. Continuous infusion of recombinant ectodomain of tumor endothelial marker 7, which specifically blocks nidogen function in Schwann cells, suppressed regenerative neurite growth in a sciatic nerve axotomy model. Taken together, it is likely that nidogen is required for proper regeneration of peripheral nerves after injury.
Lee
Hyun Kyoung
HK
Department of Physiology, College of Medicine, Dong-A University, Busan, Korea.
Seo
In Ae
IA
Suh
Duk Joon
DJ
Park
Hwan Tae
HT
D000818:Animals; D019771:Axotomy; D002465:Cell Movement; D049109:Cell Proliferation; D008297:Male; D008562:Membrane Glycoproteins / Q000502:physiology*; D008565:Membrane Proteins / Q000494:pharmacology; D009416:Nerve Regeneration; D009419:Nerve Tissue Proteins / Q000494:pharmacology; D016501:Neurites / Q000187:drug effects / Q000502:physiology* / Q000648:ultrastructure; D051381:Rats; D017207:Rats, Sprague-Dawley; D011994:Recombinant Proteins / Q000494:pharmacology; D012583:Schwann Cells / Q000166:cytology / Q000502:physiology*; D011984:Sensory Receptor Cells / Q000502:physiology*
D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; C502423:Plxdc1 protein, rat; D011994:Recombinant Proteins; C029967:nidogen