title: Lupane-type triterpene glycosides from the leaves of Acanthopanax koreanum and their in vitro cytotoxicity.
abstract: Three new lupane triterpene glycosides, acankoreosides J-L ( 1- 3), were isolated from the leaves of Acanthopanax koreanum. Based on the spectroscopic data, the chemical structures were determined as 3 alpha-hydroxy-20-oxo-30-norlupane-23,28-dioic 28- O- alpha- L-rhamnopyranosyl-(1 --> 4)- beta- D-glucopyranosyl-(1 --> 6)- beta- D-glucopyranosyl ester ( 1); 3 alpha,20,29-trihydroxylupane-23,28-dioic 28- O- alpha- L-rhamnopyranosyl-(1 --> 4)- beta- D-glucopyranosyl-(1 --> 6)- beta- D-glucopyranosyl ester ( 2); and (20S)-3 alpha-hydroxy-29,29-dimethoxylupane-23,28-dioic 28- O- alpha- L-rhamnopyranosyl-(1 --> 4)- beta- D-glucopyranosyl-(1 --> 6)- beta- D-glucopyranosyl ester ( 3). Compounds 1- 3 were evaluated for their cytotoxicity and showed moderate activity against four cell lines, A549 (lung), HL-60 (leukemia), MCF-7 (breast), and U937 (leukemia), with IC (50) values of 23.4, 36.5, 22.6, and 18.5 microM for 1; 6.8, 18.6, 23.1, and > 100 microM for 2; and 28.9, 21.8, 11.0, and 27.5 microM for 3, respectively.
authors: College of Pharmacy, Chungnam National University, Daejeon, Korea.
authors: Xuan Nhiem
authors: XN
authors: Nguyen
authors: Van Kiem
authors: VK
authors: Phan
authors: Van Minh
authors: VM
authors: Chau
authors: Thi Ha
authors: TH
authors: Do
authors: Huu Tai
authors: HT
authors: Buu
authors: Hai Yen
authors: HY
authors: Pham
authors: Huu Tung
authors: HT
authors: Nguyen
authors: Jae-Hee
authors: JH
authors: Hyun
authors: Hee-Kyoung
authors: HK
authors: Kang
authors: Young Ho
authors: YH
authors: Kim
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D028001:Eleutherococcus / Q000737:chemistry*; D006027:Glycosides / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D018515:Plant Leaves; D014315:Triterpenes / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D053978:Pentacyclic Triterpenes
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D006027:Glycosides; D010936:Plant Extracts; D014315:Triterpenes; C549464:acankoreoside J; C549465:acankoreoside K; C549466:acankoreoside L; C480546:lupane; D053978:Pentacyclic Triterpenes