Weighted spike-triggered average of a fluctuating stimulus yielding the phase response curve.
We demonstrate that the phase response curve (PRC) can be reconstructed using a weighted spike-triggered average of an injected fluctuating input. The key idea is to choose the weight to be proportional to the magnitude of the fluctuation of the oscillatory period. Particularly, when a neuron exhibits random switching behavior between two bursting modes, two corresponding PRCs can be simultaneously reconstructed, even from the data of a single trial. This method offers an efficient alternative to the experimental investigation of oscillatory systems, without the need for detailed modeling.
Ota
Kaiichiro
K
Graduate School of Informatics, Kyoto University, Kyoto 606-8501, Japan. kaiichiro@acs.i.kyoto-u.ac.jp
Nomura
Masaki
M
Aoyagi
Toshio
T