The HBZ gene, a key player in HTLV-1 pathogenesis.
Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia/lymphoma (ATL) and is also associated with a variety of lymphocyte-mediated diseases. The HTLV-1 basic leucine zipper (HBZ) gene, found to be consistently expressed in ATL, has recently been the subject of intensive research efforts. In this review, we summarize recent findings about HBZ and discuss its roles and functions not only in the virus life cycle, but also in HTLV-1 disease pathogenesis.
Matsuoka
Masao
M
Laboratory of Virus Control, Institute for Virus Research, Kyoto University, Kyoto 606-8507, Japan. mmatsuok@virus.kyoto-u.ac.jp
Green
Patrick L
PL
D050976:Basic-Leucine Zipper Transcription Factors / Q000502:physiology*; D015368:Human T-lymphotropic virus 1 / Q000472:pathogenicity*; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000821:virology*; D012191:Retroviridae Proteins; D014764:Viral Proteins / Q000502:physiology*; D037521:Virulence Factors / Q000502:physiology*
D050976:Basic-Leucine Zipper Transcription Factors; C479751:HBZ protein, human T-cell leukemia virus type I; D012191:Retroviridae Proteins; D014764:Viral Proteins; D037521:Virulence Factors