Role of fetal programming in the development of hypertension.
Epidemiological studies have suggested that size at birth contributes to increased cardiovascular disease (CVD) risk in later life. Findings from experimental studies are providing insight into the mechanisms linking impaired fetal growth and the increased risk of CVD and hypertension in adulthood. This article summarizes potential mechanisms involved in the fetal programming of hypertension and CVD, including alterations in the organs and regulatory systems critical to long-term control of sodium and volume homeostasis.
Ojeda
Norma B
NB
University of Mississippi Medical Center, Department of Physiology & Biophysics, The Center for Excellence in Cardiovascular-Renal Research, 2500 North State Street, Jackson, MS 39216-4505, USA. nojeda@physiology.umsmed.edu
Grigore
Daniela
D
Alexander
Barbara T
BT