Long-term immunogenicity of two pediatric doses of combined hepatitis A and B or monovalent hepatitis B vaccine in 8 to 10-year-old children and the effect of a challenge dose given seven years later.
A total of 465 children aged 8 to 10 years were vaccinated with 2 doses of Recombivax-HB 2.5 microg (RB) or Twinrix-Junior 10 microg/360 EL.U (TX), according to a 0 and 6 months schedule. Seven years postsecond dose, a challenge dose of vaccine was given. All vaccinees in the TX and 98% in the RB group showed an anamnestic response. Vaccination at the age of 8 to 10 years with two-pediatric doses of TX or RB given with a 6 months interval induces a long-lasting immunity in most vaccinees.
Gilca
Vladimir
V
Quebec National Public Health Institute, Quebec, Canada. vladimir.gilca@ssss.gouv.qc.ca
Dionne
Marc
M
Boulianne
Nicole
N
Murphy
Donald
D
De Serres
Gaston
G
D002648:Child; D005260:Female; D006506:Hepatitis A / Q000517:prevention & control*; D022362:Hepatitis A Vaccines / Q000276:immunology*; D006509:Hepatitis B / Q000517:prevention & control*; D017325:Hepatitis B Vaccines / Q000276:immunology*; D006801:Humans; D007114:Immunization / Q000379:methods; D007117:Immunization, Secondary / Q000379:methods; D007156:Immunologic Memory; D008297:Male; D013997:Time Factors
D022362:Hepatitis A Vaccines; D017325:Hepatitis B Vaccines