title: Total synthesis of irciniastatin A (Psymberin).
abstract: The total synthesis of (+)-iriciniastatin A (psymberin) is reported in 19 steps and 6% overall yield. Key reactions include a highly convergent enolsilane-oxocarbenium ion union to generate the C8-C25 fragment and a late-stage coupling of a hemiaminal and acid chloride to complete the synthesis.
authors: Kenan and Caudill Laboratories of Chemistry, University of North Carolina at Chapel Hill, North Carolina 27599, USA. crimmins@email.unc.edu
authors: Michael T
authors: MT
authors: Crimmins
authors: Jason M
authors: JM
authors: Stevens
authors: Gregory M
authors: GM
authors: Schaaf
mesh_terms: D002384:Catalysis; D003374:Coumarins; D015394:Molecular Structure; D011753:Pyrones / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D003374:Coumarins; D011753:Pyrones; C498383:psymberin