title: Urine proteomics biomarkers in renal transplantation: an overview.
abstract: A major goal of clinical proteomics was to identify biomarkers that can aid in the diagnosis and prognosis of different conditions. These biomarkers will not only assist the clinician in the diagnosis of a disease but they will also give directions as to which therapy may be more appropriate for each patient, thus contributing to the development of personalized medicine. This review discusses the current concepts in urine proteomics aimed at identifying predictive biomarkers that could detect the presence of acute rejection or chronic allograft dysfunction early on and for instance be used to personalize immunosuppressive therapies for kidney transplant patients.
authors: Servicio de Nefrología y Trasplante renal, Hospital Clinic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universidad de Barcelona, Spain. lfquinta@clinic.ub.es
authors: Luis F
authors: LF
authors: Quintana
authors: Elisenda
authors: E
authors: Bañon-Maneus
authors: Amanda
authors: A
authors: Solé-Gonzalez
authors: Josep M
authors: JM
authors: Campistol
mesh_terms: D003556:Cystitis / Q000175:diagnosis; D005260:Female; D006084:Graft Rejection / Q000175:diagnosis / Q000652:urine; D006085:Graft Survival; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016030:Kidney Transplantation / Q000276:immunology / Q000502:physiology*; D011237:Predictive Value of Tests; D011379:Prognosis; D011507:Proteinuria / Q000175:diagnosis*; D040901:Proteomics / Q000379:methods*; D012680:Sensitivity and Specificity; D014184:Transplantation, Homologous / Q000276:immunology / Q000473:pathology / Q000502:physiology; D014552:Urinary Tract Infections / Q000175:diagnosis
chemical_list: D007166:Immunosuppressive Agents