title: Alterations in electrocardiographic parameters after subacute exposure of fluoride and ameliorative action of aluminium sulphate in goats.
abstract: Fluorosis or crippling disease is one of the existing environmental challenges for animal and human beings in most parts of the globe. In the present study, sodium fluoride alone and with aluminium sulphate (ameliorative agent) was administered orally daily for 30 days in healthy goats of group 1 and 2, respectively, to access the effect on the electrocardiogram. All waves of Lead I, Lead II, Lead III, aVR, aVL and aVF in electrocardiographs were recorded before and after 30 days exposure of fluoride. A significant (P < 0.05) increase in P-R, Q-T and S-T intervals were observed in goats of group 1 as compared to their pre treatment values. The T wave duration was also significantly (P < 0.05) prolonged and as a result, bradycardia was observed after subacute exposure of fluoride for 30 days in group 1. But, in group 2, no such changes were observed. On the basis of results, it may be concluded that subacute toxicity of fluoride produces significant changes in different waves of electrocardiogram and aluminium sulphate has ameliorative efficacy.
authors: Division of Pharmacology and Toxicology, Faculty of Veterinary Sciences & Animal Husbandry, SKUAST-J, R.S. Pura, Jammu 181102 J&K, India. drvinaykant2001@yahoo.co.in
authors: Vinay
authors: V
authors: Kant
authors: Anil Kumar
authors: AK
authors: Srivastava
authors: Pawan Kumar
authors: PK
authors: Verma
authors: Rajinder
authors: R
authors: Raina
authors: Nrip Kishore
authors: NK
authors: Pankaj
mesh_terms: D000534:Alum Compounds / Q000008:administration & dosage / Q000633:toxicity*; D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D000829:Animals, Domestic; D001919:Bradycardia / Q000139:chemically induced; D004562:Electrocardiography; D006041:Goats / Q000378:metabolism; D012969:Sodium Fluoride / Q000008:administration & dosage / Q000633:toxicity*
chemical_list: D000534:Alum Compounds; C041524:aluminum sulfate; D012969:Sodium Fluoride