title: Differential effects of d-amphetamine on impulsive choice in spontaneously hypertensive and Wistar-Kyoto rats.
abstract: The spontaneously hypertensive rat (SHR) has been shown to exhibit three of the behavioral characteristics of attention-deficit/hyperactivity disorder: hyperactivity, attention deficit and impulsivity. This study used SHRs and a control strain to assess the effects of the commonly prescribed psychomotor stimulant, d-amphetamine, on impulsivity, defined as choice for a small, immediate over a large, delayed reinforcer. d-Amphetamine (1.0, 3.2 and 5.6 mg/kg) was administered to SHR and Wistar-Kyoto rats (WKY; their progenitor strain) before sessions of a choice task involving small, immediate and larger, delayed food reinforcers. As reported earlier, SHRs were more impulsive than WKYs (they preferred the smaller, immediate reinforcer). d-Amphetamine had no effect on preference for the SHRs, but increased choices for the small, immediate reinforcer for the WKYs at the 1.0 and 3.2 doses. Thus, d-amphetamine did not reduce impulsivity in the already impulsive SHRs, but did increase impulsivity in rats that were not already impulsive.
authors: Department of Psychology, Central Michigan University, Mount Pleasant, Michigan 48859, USA.
authors: Dennis J
authors: DJ
authors: Hand
authors: Andrew T
authors: AT
authors: Fox
authors: Mark P
authors: MP
authors: Reilly
mesh_terms: D000661:Amphetamine / Q000494:pharmacology*; D000704:Analysis of Variance; D000818:Animals; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D002755:Choice Behavior / Q000187:drug effects*; D003216:Conditioning, Operant / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D007175:Impulsive Behavior / Q000503:physiopathology*; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D011930:Reaction Time / Q000187:drug effects; D012055:Reinforcement Schedule; D012054:Reinforcement, Psychology; D013045:Species Specificity; D013997:Time Factors
chemical_list: D000697:Central Nervous System Stimulants; D000661:Amphetamine