title: Intraperitoneal injection of extracted microcystins results in hypovolemia and hypotension in crucian carp (Carassius auratus).
abstract: Circulatory responses of crucian carp injected intraperitoneally with extracted microcystins (MCs) were studied at sublethal and lethal doses (150 and 600 microg MC kg(-1) body mass, respectively). Mean arterial blood pressure (MAP), heart rate, hematocrit (Hct), red blood cell (RBC) counts, and circulating blood volume (BV) were assayed at 0, 1, 3, 12, 24, and 48 h post-toxin administration. MAP decreased significantly in a dose-dependent manner over time. Within the 48-h test period, the lethal dose as well as the sublethal dose resulted in a steady decline of MAP without recovery. Heart rate significantly increased within 24 h post-injection as blood pressure significantly dropped, then showed a terminal decline to the control level. The dose-dependent decreases in BV and Hct were directly related to the drop in MAP. Intraperitoneal injection of a lethal dose of MCs led to hepatic and gill hemorrhage. Consequently, crucian carp given MCs suffered from hypovolemic hypotensive shock.
authors: Key Laboratory of Freshwater Biodiversity Conservation and Utilization of Ministry of Agriculture, College of Fishery, Huazhong Agricultural University, Wuhan 430070, People's Republic of China.
authors: Dapeng
authors: D
authors: Li
authors: Ping
authors: P
authors: Xie
authors: Xuezhen
authors: X
authors: Zhang
authors: Yanyan
authors: Y
authors: Zhao
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001810:Blood Volume / Q000187:drug effects; D002347:Carps; D004906:Erythrocyte Count; D006339:Heart Rate / Q000187:drug effects; D007022:Hypotension / Q000139:chemically induced*; D020896:Hypovolemia / Q000139:chemically induced*; D007274:Injections, Intraperitoneal; D052998:Microcystins / Q000008:administration & dosage / Q000633:toxicity*
chemical_list: D052998:Microcystins