Pathophysiology of burns.
Burn injury represents a significant problem worldwide. Advances in therapy strategies, based on better understanding of the pathophysiologic responses after burn injury have improved the clinical outcome of patients with burn injuries over the past years. This article describes the present understanding of the pathophysiology of a burn injury including both the local and systemic responses, focusing on the many facets of organ and systemic effects directly resulting from hypovolemia and circulating mediators following burn trauma.
Keck
Maike
M
Division of Plastic and Reconstructive Surgery, Department of Surgery, Medical University of Vienna, Vienna, Austria. maike.keck@meduniwien.ac.at
Herndon
David H
DH
Kamolz
Lars P
LP
Frey
Manfred
M
Jeschke
Marc G
MG
D000804:Angiotensin II / Q000502:physiology; D000818:Animals; D002056:Burns / Q000209:etiology / Q000503:physiopathology* / Q000628:therapy; D002395:Catecholamines / Q000502:physiology; D004487:Edema / Q000503:physiopathology; D006439:Hemodynamics / Q000502:physiology; D006632:Histamine / Q000502:physiology; D006801:Humans; D020896:Hypovolemia / Q000503:physiopathology; D018836:Inflammation Mediators / Q000097:blood; D010972:Platelet Activating Factor / Q000502:physiology; D011453:Prostaglandins / Q000502:physiology; D012701:Serotonin / Q000502:physiology; D012867:Skin / Q000503:physiopathology; D017695:Soft Tissue Injuries / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D013931:Thromboxanes / Q000502:physiology; D014655:Vascular Resistance / Q000502:physiology; D014667:Vasopressins / Q000502:physiology
D002395:Catecholamines; D018836:Inflammation Mediators; D010972:Platelet Activating Factor; D011453:Prostaglandins; D013931:Thromboxanes; D014667:Vasopressins; D000804:Angiotensin II; D012701:Serotonin; D006632:Histamine