Double versus single intrauterine insemination for unexplained infertility: a meta-analysis of randomized trials.
OBJECTIVE
To investigate the effect of double versus single intrauterine insemination (IUI) per treatment cycle in women with unexplained infertility.


METHODS
Meta-analysis of randomized controlled trials.


METHODS
Clinical pregnancy rates per couple.


METHODS
Electronic searches of the Cochrane Central Trials Registry and Medline without year and language restriction through March 2009; hand searching of the abstract books of the European Society of Human Reproduction and Embryology and American Society for Reproductive Medicine annual meetings (2001-2008).


RESULTS
Six randomized trials, involving 829 women, were included in the analysis. Fifty-four (13.6%) clinical pregnancies were recorded for treatment with double IUI and 62 (14.4%) for treatment with single IUI. There was no significant difference between the single and double IUI groups in the probability for clinical pregnancy (odds ratio, 0.92; 95% confidence interval, 0.58-1.45; P=0.715).


CONCLUSIONS
Double IUI offers no clear benefit in the overall clinical pregnancy rate in couples with unexplained infertility.
Polyzos
Nikolaos P
NP
Section of Obstetrics and Gynaecology and Public Health, Panhellenic Association for Continual Medical Research, Athens, Greece. Electronic address: n.polyzos@gmail.com.
Tzioras
Spyridon
S
Section of Obstetrics and Gynaecology and Public Health, Panhellenic Association for Continual Medical Research, Athens, Greece.
Mauri
Davide
D
Section of Obstetrics and Gynaecology and Public Health, Panhellenic Association for Continual Medical Research, Athens, Greece.
Tatsioni
Athina
A
Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts.
D000328:Adult; D000465:Algorithms; D005191:Family Characteristics; D005260:Female; D005843:Geography; D006801:Humans; D007246:Infertility / Q000209:etiology / Q000628:therapy*; D007315:Insemination, Artificial / Q000379:methods*; D008297:Male; D011247:Pregnancy; D018873:Pregnancy Rate; D011786:Quality Control; D016032:Randomized Controlled Trials as Topic / Q000706:statistics & numerical data*; D014599:Uterus