title: Curcumin is not a ligand for peroxisome proliferator-activated receptor-γ
abstract: Curcumin, a compound found in the spice turmeric, has been shown to possess a number of beneficial biological activities exerted through a variety of different mechanisms. Some curcumin effects have been reported to involve activation of the nuclear transcription factor peroxisome proliferator-activated receptor-γ (PPAR-γ), but the concept that curcumin might be a PPAR-γ ligand remains controversial. Results reported here demonstrate that, in contrast to the PPAR-γ ligands ciglitazone and rosiglitazone, curcumin is inactive in five different reporter or DNA-binding assays, does not displace [(3)H]rosiglitazone from the PPAR-γ ligand-binding site, and does not induce PPAR-γ-dependent differentiation of preadipocytes, while its ability to inhibit fibroblast-to-myofibroblast differentiation is not affected by any of four PPAR-γ antagonists. These multiple lines of evidence conclusively demonstrate that curcumin is not a PPAR-γ ligand and indicate the need for further investigation of the mechanisms through which the compound acts.
authors: Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor, MI 48109.
authors: Venkata R
authors: VR
authors: Narala
authors: Monica R
authors: MR
authors: Smith
authors: Ravi K
authors: RK
authors: Adapala
authors: Rajesh
authors: R
authors: Ranga
authors: Kalpana
authors: K
authors: Panati
authors: Bethany B
authors: BB
authors: Moore
authors: Todd
authors: T
authors: Leff
authors: Vudem D
authors: VD
authors: Reddy
authors: Anand K
authors: AK
authors: Kondapi
authors: Raju C
authors: RC
authors: Reddy