title: Identification of 3-hydroxy-2-(3-hydroxyphenyl)-4H-1-benzopyran-4-ones as isoform-selective PKC-zeta inhibitors and potential therapeutics for psychostimulant abuse.
abstract: From a screen of small molecule libraries to identify potential therapeutics for psychostimulant abuse, 3-hydroxy-2-(3-hydroxyphenyl)-4H-1-benzopyran-4-ones were shown to be isoform-selective PKC-zeta inhibitors.
authors: Department of Chemistry, Duke University, Durham, North Carolina 27708, USA.
authors: Langtian
authors: L
authors: Yuan
authors: Jin-Soo
authors: JS
authors: Seo
authors: Nam Sook
authors: NS
authors: Kang
authors: Shahar
authors: S
authors: Keinan
authors: Sarah E
authors: SE
authors: Steele
authors: Gregory A
authors: GA
authors: Michelotti
authors: William C
authors: WC
authors: Wetsel
authors: David N
authors: DN
authors: Beratan
authors: Young-Dae
authors: YD
authors: Gong
authors: Tong H
authors: TH
authors: Lee
authors: Jiyong
authors: J
authors: Hong
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001578:Benzopyrans; D019556:COS Cells; D002522:Chlorocebus aethiops; D005419:Flavonoids / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D007700:Kinetics; D008958:Models, Molecular; D020033:Protein Isoforms; D011493:Protein Kinase C / Q000037:antagonists & inhibitors* / Q000378:metabolism; D047428:Protein Kinase Inhibitors / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D054852:Small Molecule Libraries; D013379:Substrate Specificity; D000099221:Protein Kinase C zeta
chemical_list: D001578:Benzopyrans; D005419:Flavonoids; D020033:Protein Isoforms; D011493:Protein Kinase C; D047428:Protein Kinase Inhibitors; D054852:Small Molecule Libraries; D000099221:Protein Kinase C zeta