Treatment of heterogeneous emphysema using the spiration IBV valves.
Ninety-eight emphysema patients were treated at 13 international sites during a 3-year series of single-arm, open-label studies with the IBV valve and a multi-lobar treatment approach. Fifty six percent of subjects had a clinically meaningful improvement in health-related quality of life, but standard pulmonary function and exercise studies were insensitive effectiveness measures. Quantitative CT analyses of regional lung changes showed lobar volume changes in over 85% of subjects. Lung volume reduction was an uncommon mechanism for a treatment response with bilateral upper lobe treatment. A redirection of inspired air, an interlobar shift to health-ier lung tissue, was the most common mechanism for a valve treatment response.
Springmeyer
Steven C
SC
School of Medicine, University of Washington, Seattle, WA, USA. sspringmeyer@spiration.com
Bolliger
Chris T
CT
Waddell
Thomas K
TK
Gonzalez
Xavier
X
Wood
Douglas E
DE
D000368:Aged; D001999:Bronchoscopy; D015331:Cohort Studies; D004867:Equipment Design; D017079:Exercise Tolerance; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D008875:Middle Aged; D011013:Pneumonectomy / Q000295:instrumentation*; D011656:Pulmonary Emphysema / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D012189:Retrospective Studies; D016896:Treatment Outcome