title: Congenital nasal pyriform aperture stenosis: diagnosis and management.
abstract: OBJECTIVE
  To review diagnosis and treatment modalities in congenital nasal pyriform aperture stenosis in a newborn population.
  
  
  METHODS
  A 6-year retrospective case series review. Mean follow-up of 21.8 months.
  
  
  METHODS
  University hospital, tertiary care center.
  
  
  METHODS
  Twenty-one consecutive patients treated for congenital nasal pyriform aperture stenosis. Diagnosis was suspected on physical examination and confirmed by computed tomography scan. Associated abnormalities were present in 15 patients.
  
  
  METHODS
  Nineteen patients underwent surgical treatment focused on external bony margins of pyriform aperture and the osseous anterior edge of the inferior turbinate, drilling by a sublabial approach and associated with a partial turbinectomy in seven cases. A stent was placed for 7 to 10 days. A conservative treatment based on topical nasal decongestants and gastroesophageal reflux treatment was proposed for two patients.
  
  
  RESULTS
  Postoperative follow-up revealed septal ulceration in five cases with septal perforation in one case and development of synechiae in two cases. Follow-up revealed normal nasal breathing and pyriform aperture growth after surgery.
  
  
  CONCLUSIONS
  Our experience confirmed the link described between congenital nasal pyriform aperture stenosis and holoprosencephaly, but associated extracraniofacial malformations suggest that congenital nasal pyriform aperture stenosis should be integrated in a systemic malformative syndrome or genetic disorder and lead us to propose an exhaustive dysmorphology assessment. Some infants may be treated by conservative management, and severely affected patients may undergo surgery by a sublabial approach.
authors: Department of Otolaryngolog-Head and Neck Surgery, University Hospital of Lille, France.
authors: Marion
authors: M
authors: Devambez
authors: Alexis
authors: A
authors: Delattre
authors: Pierre
authors: P
authors: Fayoux
mesh_terms: D003251:Constriction, Pathologic / Q000151:congenital / Q000175:diagnosis / Q000601:surgery; D004724:Endoscopy; D005260:Female; D005500:Follow-Up Studies; D005764:Gastroesophageal Reflux / Q000150:complications / Q000628:therapy; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009296:Nasal Cavity / Q000002:abnormalities* / Q000254:growth & development / Q000601:surgery; D014663:Nasal Decongestants / Q000627:therapeutic use; D009297:Nasal Mucosa / Q000473:pathology; D015508:Nasal Obstruction / Q000151:congenital* / Q000175:diagnosis / Q000601:surgery; D009300:Nasal Septum / Q000473:pathology / Q000601:surgery; D009668:Nose Diseases / Q000209:etiology; D011183:Postoperative Complications; D012119:Respiration; D012127:Respiratory Distress Syndrome, Newborn / Q000209:etiology; D012189:Retrospective Studies; D015607:Stents; D000267:Tissue Adhesions / Q000209:etiology; D014057:Tomography, X-Ray Computed; D014420:Turbinates / Q000601:surgery; D014456:Ulcer / Q000209:etiology
chemical_list: D014663:Nasal Decongestants