title: A case of primary histiocytic sarcoma arising from thyroid gland.
abstract: Histiocytic sarcoma (HS) is an extremely rare true histiocytic malignancy. We report a case of HS arising from thyroid gland in a 69 year-old man. Following subtotal thyroidectomy, a histopathologic, immunohistologic, and genotypic examination revealed HS. This tumor was composed of large spindle or round epithelioid cells with abundant eosinophilic cytoplasm. The neoplastic cells were positive for macrophage-associated antigen CD68, CD163, and lysozymes, as well as CD45, HLA- DR, DP, DQ, and S100, most consistent with a diagnosis of HS. The BIOMED-2 multiplex PCR analysis showed polyclonal B- and T-cell populations. To our knowledge, this is the first report of a rare entity HS involving thyroid gland using a comprehensive immunophenotyping panel including CD163 as well as molecular studies to establish the true histiocytic nature of these lesions.
authors: Department of Pathology, Xi Jing Hospital, 4th Military Medical University, No. 17 Chang Le Xi Road, Xi'an, Shaanxi, 710032, China.
authors: Lu
authors: L
authors: Yu
authors: Shou Jing
authors: SJ
authors: Yang
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D054747:Histiocytic Sarcoma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D008297:Male; D013964:Thyroid Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D013965:Thyroidectomy
chemical_list: D014408:Biomarkers, Tumor