[Research advancement on relationship between Epstein-Barr virus and breast cancer].
The etiology of breast cancer is still unclear. The well-known risk factors, including reproductive and other factors affecting circulating sex hormones, and genetic susceptibility, explain only about 50% of all breast cancer incidence. More and more studies have shown interest in the possibility that breast cancer may be caused by viral infection. Epstein-Barr virus (EBV) is one of the candidate viruses, but the association of EBV with breast cancer remains controversial. Here we reviewed the studies on EBV biology and the association of EBV with breast cancer, including EBV detection in breast cancer tissues, serological tests, cytologic experiments and clinical analyses, and described the limitations of current studies and future directions.
He
Jian-Rong
JR
School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, 510080, P.R. China.
Song
Er-Wei
EW
Ren
Ze-Fang
ZF
D000914:Antibodies, Viral / Q000097:blood*; D000956:Antigens, Viral / Q000276:immunology; D001943:Breast Neoplasms / Q000097:blood / Q000378:metabolism / Q000473:pathology / Q000821:virology*; D036022:Capsid Proteins / Q000276:immunology; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D020031:Epstein-Barr Virus Infections / Q000097:blood / Q000378:metabolism / Q000473:pathology* / Q000821:virology; D019309:Epstein-Barr Virus Nuclear Antigens / Q000276:immunology / Q000378:metabolism; D005260:Female; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D008207:Lymphatic Metastasis; D015534:Trans-Activators / Q000276:immunology; D014763:Viral Matrix Proteins / Q000378:metabolism; D014764:Viral Proteins / Q000378:metabolism
D000914:Antibodies, Viral; D000956:Antigens, Viral; C063676:BZLF1 protein, Herpesvirus 4, Human; D036022:Capsid Proteins; C402641:EBNA-2 protein, Human herpesvirus 4; C037662:EBV-associated membrane antigen, Epstein-Barr virus; D019309:Epstein-Barr Virus Nuclear Antigens; C041788:Epstein-Barr viral capsid antigen; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D015534:Trans-Activators; D014763:Viral Matrix Proteins; D014764:Viral Proteins; C417029:EBV-encoded nuclear antigen 1