title: [Infection-triggered familial or recurrent acute necrotizing encephalopathy].
abstract: Acute necrotizing encephalopathy (ANE) presents in children after common viral infections. Most cases of ANE are non-familial and non-recurrent and have been mainly reported in Asian patients, although ANE affects children worldwide. Recently, missense mutations in the gene encoding the nuclear pore protein Ran Binding Protein 2 (RANBP2) have been found in several families with familial or recurrent cases of ANE. We describe a Spanish family with familial and recurrent ANE without mutations in RANBP2. Mutations in RANBP2 are not the sole susceptibility alleles for familial or recurrent ANE.
authors: Servicio de Pediatría, Hospital Universitario Reina Sofía, Córdoba, España. elolaso@gmail.com
authors: E
authors: E
authors: López-Laso
authors: M E
authors: ME
authors: Mateos-González
authors: J L
authors: JL
authors: Pérez-Navero
authors: R
authors: R
authors: Camino-León
authors: P
authors: P
authors: Briones
authors: D E
authors: DE
authors: Neilson
mesh_terms: D002675:Child, Preschool; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007223:Infant; D007239:Infections; D004684:Leukoencephalitis, Acute Hemorrhagic / Q000235:genetics* / Q000382:microbiology; D008297:Male; D010375:Pedigree; D012008:Recurrence