title: Phosphabarrelene-modified Rh-catalysts: a new and selective route towards hydroxy-functionalized bicyclic imidazoles via tandem reactions.
abstract: 8-Hydroxy-6-methyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine was formed selectively in high yields from N-(beta-methallyl)imidazole by a tandem hydroformylation-cyclization sequence, representing a novel one-pot catalytic synthesis of bicyclic imidazole derivatives.
authors: Schuit Institute of Catalysis, Laboratory for Homogeneous Catalysis, Eindhoven University of Technology, 5600 MB Eindhoven, The Netherlands.
authors: Patrick S
authors: PS
authors: Bäuerlein
authors: Ismael Arenas
authors: IA
authors: Gonzalez
authors: Jarno J M
authors: JJ
authors: Weemers
authors: Martin
authors: M
authors: Lutz
authors: Anthony L
authors: AL
authors: Spek
authors: Dieter
authors: D
authors: Vogt
authors: Christian
authors: C
authors: Müller
mesh_terms: D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D018360:Crystallography, X-Ray; D003500:Cyclization; D007093:Imidazoles / Q000138:chemical synthesis / Q000737:chemistry*; D008968:Molecular Conformation; D011725:Pyridines / Q000138:chemical synthesis / Q000737:chemistry*; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: C544488:8-hydroxy-6-methyl-5,6,7,8-tetrahydroimidazo(1,2-a)pyridine; D001643:Bridged Bicyclo Compounds; D007093:Imidazoles; D011725:Pyridines; D012238:Rhodium