title: [Study on natural borneol and synthetic borneol affecting mucosal permeability of gardenia extract].
abstract: OBJECTIVE
  To observe the influence of natural borneol and synthetic borneol on mucosal permeability of Gardenia extract.
  
  
  METHODS
  Taken frog skin as a vitro model to study the vitro mucosal permeation the impacts of the natural borneols and synthetic borneols on the P(app) of the Jasminoidin were studied, and the effect of different borneols on the stability of Jasminoidin were investigated. Compared the 10 h accumulated infiltration rate of each group the effects of influence factors,such as C(Ge), C(B) and rotation speed on P(app) were investigated by using response surface method.
  
  
  RESULTS
  The P(app) of Jasminoidin of natural borneol and synthetic borneol group were 1.44 fold and 1.77 fold of control group (P < 0.01). For two borneol groups, the results also showed a significant difference too (P < 0.05). Jasminoidin began to degrade about 8 h after the effect of frog skin for control group and synthetic borneol group, but was stable within 12 h for natural borneol group. The accumulated permeation rate of 10 h was same for different borneol groups. It was about 1.3 fold of control group. The C(Ge) had a salinence influence on the P(app) (P < 0.01) and C(B) had a salience influence on time-lag (P < 0.01).
  
  
  CONCLUSIONS
  Both the natural borneol and synthetic borneol can accelerate the permeation of Jasminoidin and the synthetic borneol has stronger effect on the P(app). Both two different borneol can reduce the degradation effect of frog skin to Jasminoidin, but the natural borneol has a better protect effect on it. By using more natural borneol, the mucosal permeability of Gardenia extract can be increased, the time-lag can be reduced, and Jasminoidin has better stability.
authors: School of Chinese Pharmacy, Beijing University of Traditional Chinese Medicine, Beijing 100102, China.
authors: Yang
authors: Y
authors: Lu
authors: Shouying
authors: S
authors: Du
authors: Zongling
authors: Z
authors: Yao
authors: Peiyue
authors: P
authors: Zhao
authors: Yongsong
authors: Y
authors: Zhai
mesh_terms: D000279:Administration, Cutaneous; D001892:Camphanes / Q000138:chemical synthesis / Q000493:pharmacokinetics*; D004304:Dosage Forms; D004365:Drugs, Chinese Herbal / Q000737:chemistry; D032062:Gardenia / Q000737:chemistry*; D039823:Iridoids / Q000494:pharmacology; D009092:Mucous Membrane / Q000378:metabolism*; D009297:Nasal Mucosa / Q000378:metabolism; D010539:Permeability; D012867:Skin / Q000378:metabolism; D012869:Skin Absorption
chemical_list: D001892:Camphanes; D004304:Dosage Forms; D004365:Drugs, Chinese Herbal; D039823:Iridoids; C007835:geniposide; C022871:isoborneol