[Antimicrobial activity of tebipenem against various clinical isolates from various specimen, mainly urinary tract].
Tebipenem is the active metabolite of ME1211, tebipenem pivoxil, a novel oral carbapenem that possesses potent activity against almost pathogens except for Pseudomonas aeruginosa. In this study, we compared the susceptibility of tebipenem with current antibiotics against various organisms isolated from various specimen, mainly urinary tract. Tebipenem had a potent activity against Neisseria gonorrhoeae; its activity was comparable to it of cefixime that has most potent activity among oral antibiotics. Against Enterococcus faecalis, the activity of tebipenem was comparable to the activities of ampicillin and amoxicillin, and superior to it of faropenem. Against Citrobacter freundii, Escherichia coli , Klebsiella pneumoniae, and Enterobacter spp. including extended-spectrum beta-lactamase producers, tebipenem had a potent activity with or without ceftazidime-resistance.
Muratani
Tetsuro
T
Department of Urology, School of Medicine, University of Occupational and Environmental Health.
Doi
Kazutake
K
Kobayashi
Tomoko
T
Nakamura
Tamaki
T
Matsumoto
Tetsuro
T
D015780:Carbapenems / Q000494:pharmacology*; D016971:Citrobacter freundii / Q000187:drug effects* / Q000302:isolation & purification; D024881:Drug Resistance, Bacterial; D004754:Enterobacter / Q000187:drug effects* / Q000302:isolation & purification; D013293:Enterococcus faecalis / Q000187:drug effects* / Q000302:isolation & purification; D004926:Escherichia coli / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000302:isolation & purification; D014552:Urinary Tract Infections / Q000382:microbiology*
D015780:Carbapenems; C500135:tebipenem