Pheochromocytoma, papillary thyroid carcinoma.
A 53-year-old woman presented with labile and difficult to control hypertension on 3 different anti-hypertensive medications. Abdominal computed tomography and ultrasonography of the thyroid gland showed a 1.8 cm thyroid nodule. Fine needle aspiration biopsy of the thyroid nodule revealed papillary thyroid carcinoma. Serum thyroid stimulating hormone and free thyroxine, calcitonin, carcinoembryonic antigen, intact parathyroid hormone, and calcium levels were within normal limits. A 24-hour urine metanephrine showed significant elevation in urine metanephrine of approximately 3 times the upper limit of normal, and the result of 131I-metaiodobenzyleguanjdjne (131I-MIBG) scintigraphy confirmed that the adrenal mass was pheochromocytoma. Right adrenalectomy and total thyroidectomy were performed. The final pathology was pheochromocytoma and papillary thyroid carcinoma. An analysis of c-ret porto-oncogene mutation yielded a negative result. This unusual association of 2 tumors represents a new entity.
Nasser
Tariq
T
Division of Endocrinology, King Khalid National Guard Hospital, Jeddah, Kingdom of Saudi Arabia.
Qari
Faiza
F
D000310:Adrenal Gland Neoplasms / Q000235:genetics / Q000601:surgery*; D000315:Adrenalectomy; D004252:DNA Mutational Analysis; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008676:Metanephrine / Q000652:urine; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000235:genetics / Q000601:surgery*; D010673:Pheochromocytoma / Q000235:genetics / Q000601:surgery*; D051096:Proto-Oncogene Proteins c-ret / Q000235:genetics; D013964:Thyroid Neoplasms / Q000235:genetics / Q000601:surgery*; D013965:Thyroidectomy
D008676:Metanephrine; D051096:Proto-Oncogene Proteins c-ret