[Effects of recurrent herpetic infection on functional activity of T-cells in patients with rheumatoid arthritis].
OBJECTIVE
To evaluate effects of recurrent herpetic infection on functional activity of regulatory cell subpopulations in patients with rheumatoid arthritis.


METHODS
We studied in vitro production of marker cytokines of type 1 T-helpers (IL-2), type 2 T-helpers (IL-4), type 3 T-helpers TGFbeta and type 1 T-regulators (IL-10) and counted CD4+CD25+ T-cells in the blood of patients with recurrent herpetic infection and having no clinical manifestations of Herpes virus reactivation.


RESULTS
Patients with recurrent herpes had more active production of IL-10, but reduced count of CD4+CD25+ lymphocytes.


CONCLUSIONS
IL-10 hyperproduction observed in recurrent herpetic infection may contribute to progression of rheumatoid arthritis.
Sviridova
V S
VS
Kologrivova
E N
EN
Pronina
N A
NA
Eliseeva
L V
LV
Naslednikova
I O
IO
D000328:Adult; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000276:immunology* / Q000503:physiopathology; D006566:Herpesviridae Infections / Q000150:complications / Q000276:immunology*; D006801:Humans; D016753:Interleukin-10 / Q000096:biosynthesis / Q000276:immunology; D007376:Interleukin-2 / Q000096:biosynthesis / Q000276:immunology; D015847:Interleukin-4 / Q000096:biosynthesis / Q000276:immunology; D008875:Middle Aged; D012008:Recurrence; D013601:T-Lymphocytes / Q000276:immunology*; D016212:Transforming Growth Factor beta / Q000096:biosynthesis / Q000276:immunology
D007376:Interleukin-2; D016212:Transforming Growth Factor beta; D016753:Interleukin-10; D015847:Interleukin-4