Six-minute walk test in patients with Down syndrome: validity and reproducibility.
OBJECTIVE
To examine the validity of the six-minute walk test (6MWT) as a tool to evaluate functional exercise performance in patients with Down syndrome (DS).


METHODS
Comparison of the six-minute walk distance (6MWD) in 2 distinct groups of DS patients: with and without severe cardiac disease. To test reproducibility, a group of patients with DS performed the 6MWT twice.


METHODS
Tertiary referral centers for patients with congenital heart defects and outpatient clinics for people with intellectual disabilities.


METHODS
Adult patients with DS with (n=29) and without (n=52) severe cardiac disease categorized by cardiac echocardiography.


METHODS
Not applicable.


METHODS
Distance walked on the 6MWT.


RESULTS
The mean 6MWD in the group with severe cardiac disease was 289+/-104 m and in the group without severe cardiac disease 280+/-104 m (P=.70). Older age, female sex, and severe level of intellectual disability were all found to be independently and significantly correlated with a lower 6MWD (r=.67, P<.001). The paired 6MWD was not significantly different (310+/-88 m vs 317+/-85 m; P=.40) in patients who performed the 6MWT twice. The coefficient of variation was 11%.


CONCLUSIONS
The 6MWD between the 2 groups was not significantly different. However, the walking distance inversely correlated with the level of intellectual disability. Therefore, the 6MWT is not a valid test to examine cardiac restriction in adult patients with DS.
Vis
Jeroen C
JC
Department of Cardiology, Academic Medical Centre, Amsterdam, The Netherlands. j.c.vis@amc.uva.nl
Thoonsen
Hanneke
H
Duffels
Marielle G
MG
de Bruin-Bon
Rianne A
RA
Huisman
Sylvia A
SA
van Dijk
Arie P
AP
Hoendermis
Elke S
ES
Berger
Rolf M
RM
Bouma
Berto J
BJ
Mulder
Barbara J
BJ
D000328:Adult; D004314:Down Syndrome / Q000503:physiopathology*; D005080:Exercise Test / Q000379:methods*; D005260:Female; D006331:Heart Diseases / Q000503:physiopathology*; D006801:Humans; D016014:Linear Models; D008297:Male; D015203:Reproducibility of Results; D018709:Statistics, Nonparametric; D016138:Walking / Q000502:physiology*