[Inhibitory effect of Sanlengwan on expression of adhesion molecules ICAM-1, CD44 in rats of endometriosis].
OBJECTIVE
To explore the effect of Sanlengwan (SLW) on adhesion molecules expression and the accretion in ectopic endometrium of rats.


METHODS
Endometriosis was established by surgical implant of endometrial tissue which belong to its body. Forty EMS model rats were randomly divided into five groups: model control group, three dose of SLW groups and anastrozole group. Meanwhile, eight normal rats were used as the normal group. All the rats were treated for 4 weeks respectively, and the volume of grafts were measured by vernier caliper, morphological changes were measured by HE stain, and the adhesion molecules, ICAM-1 and CD44 protein, were also measured by immunohistochemical test before and after treatment of SLW.


RESULTS
SLW markedly reduced the volume of grafts, improve the morphological characters and decreased the expression of ICAM-1 and CD44 in ectopic endometrial tissue.


CONCLUSIONS
SLW can inhibit the accretion of ectopic endometrium tissue of rats, and its mechanism might be associated with inhibiting the expression of ICAM-1 and CD44 protein.
Li
Zhuoheng
Z
Pharmaceutical Sciences College of Chongqing University of Medical Science, Chongqing 400016, China. cissylzh1983@yahoo.com.cn
Li
Ao
A
Chen
Gang
G
He
Yao
Y
Wang
Jing
J
Xu
Xiaoyu
X
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D015815:Cell Adhesion Molecules / Q000235:genetics / Q000378:metabolism*; D004715:Endometriosis / Q000378:metabolism*; D004717:Endometrium / Q000187:drug effects / Q000378:metabolism; D005260:Female; D015870:Gene Expression / Q000187:drug effects*; D018960:Hyaluronan Receptors / Q000235:genetics / Q000378:metabolism*; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics / Q000378:metabolism*; D007371:Interferon-gamma; D008516:Medicine, Chinese Traditional; D016328:NF-kappa B / Q000494:pharmacology; D028321:Plant Preparations / Q000494:pharmacology*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D017154:Stromal Cells / Q000187:drug effects / Q000378:metabolism
D000975:Antioxidants; D015815:Cell Adhesion Molecules; D018960:Hyaluronan Receptors; D016328:NF-kappa B; D028321:Plant Preparations; D012333:RNA, Messenger; D018799:Intercellular Adhesion Molecule-1; D007371:Interferon-gamma