title: Altered release of regulated upon activation, normal T-cell expressed and secreted protein from human, normal platelets: contribution of distinct HIV-1MN gp41 peptides.
abstract: Platelets can bind HIV and, in turn, be altered in with respect to and function during HIV progression. This study examines the secretion of normal platelets after exposure to recombinant HIV-1MN gp120 or gp41 peptides. There was a modest but significant decrease in regulated upon activation, normal T-cell expressed and secreted protein production in the presence of two out of 10 peptides, which was restored by monoclonal antibodies to gp41. Our data provide novel information on possible primary interactions between platelets and HIV env proteins.
authors: aEFS Auvergne-Loire, and GIMAP-EA3064, Université de Saint-Etienne--membre de l'Université de Lyon, Faculté de Médecine, Saint-Etienne, France.
authors: Fabrice
authors: F
authors: Cognasse
authors: Hind
authors: H
authors: Hamzeh-Cognasse
authors: Julien
authors: J
authors: Berthet
authors: Pauline
authors: P
authors: Damien
authors: Frédéric
authors: F
authors: Lucht
authors: Bruno
authors: B
authors: Pozzetto
authors: Olivier
authors: O
authors: Garraud
mesh_terms: D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism / Q000821:virology; D002478:Cells, Cultured; D018946:Chemokine CCL5 / Q000096:biosynthesis; D015699:HIV Envelope Protein gp120 / Q000494:pharmacology*; D015700:HIV Envelope Protein gp41 / Q000494:pharmacology*; D015497:HIV-1; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology; D011994:Recombinant Proteins / Q000494:pharmacology
chemical_list: D018946:Chemokine CCL5; D015699:HIV Envelope Protein gp120; D015700:HIV Envelope Protein gp41; D011994:Recombinant Proteins