title: A phase code for memory could arise from circuit mechanisms in entorhinal cortex.
abstract: Neurophysiological data reveals intrinsic cellular properties that suggest how entorhinal cortical neurons could code memory by the phase of their firing. Potential cellular mechanisms for this phase coding in models of entorhinal function are reviewed. This mechanism for phase coding provides a substrate for modeling the responses of entorhinal grid cells, as well as the replay of neural spiking activity during waking and sleep. Efforts to implement these abstract models in more detailed biophysical compartmental simulations raise specific issues that could be addressed in larger scale population models incorporating mechanisms of inhibition.
authors: Center for Memory and Brain, Department of Psychology and Program in Neuroscience, Boston University, 2 Cummington Street, Boston, MA 02215, USA. hasselmo@bu.edu
authors: Michael E
authors: ME
authors: Hasselmo
authors: Mark P
authors: MP
authors: Brandon
authors: Motoharu
authors: M
authors: Yoshida
authors: Lisa M
authors: LM
authors: Giocomo
authors: James G
authors: JG
authors: Heys
authors: Erik
authors: E
authors: Fransen
authors: Ehren L
authors: EL
authors: Newman
authors: Eric A
authors: EA
authors: Zilli
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D001683:Biological Clocks / Q000502:physiology; D018728:Entorhinal Cortex / Q000166:cytology / Q000502:physiology*; D006801:Humans; D008568:Memory / Q000502:physiology*; D008959:Models, Neurological; D009415:Nerve Net / Q000166:cytology / Q000502:physiology*; D009433:Neural Inhibition / Q000502:physiology; D009474:Neurons / Q000502:physiology*; D014851:Wakefulness / Q000502:physiology