Variations in the pharmacological management of patients treated with carotid endarterectomy: a survey of European vascular surgeons.
OBJECTIVE
The peri-operative use of antiplatelet, anticoagulant and other drugs for patients undergoing carotid endarterectomy (CEA) is unclear and consensus is lacking. This study aimed to assess the current peri-operative practice of European vascular surgeons with respect to antiplatelet and other medications for patients undergoing CEA.


METHODS
Online questionnaire study.


METHODS
Members of the Vascular Society of Great Britain & Ireland and European Society for Vascular Surgery were invited to complete an online survey in March 2008. Surgeons were asked about their preferences for the peri-operative administration of antiplatelet, statin and other medications for patients undergoing carotid endarterectomy.


RESULTS
Partial or complete responses were received from 399/650 (61.4%) surgeons with a collective annual throughput of >11500 CEA procedures. For symptomatic and asymptomatic patients, 20/392 (5%) and 47/392 (12%) of surgeons would stop aspirin before surgery and 170/392 (43%) and 217/392 (55%) of surgeons would stop Clopidogrel prior to CEA. Of surgeons who would stop Clopidogrel, 84/170 (49%) and 124/217 (57%) would do so >7 days before surgery for symptomatic and asymptomatic patients respectively. 12/393 (3%) surgeons would prescribe one 75 mg dose of Clopidogrel on the evening before surgery. Intra-operative Dextran was used selectively by 40/395 (10%). Only 78/393 (20%) would delay surgery to commence a statin. Intra-operatively, 348/394 (88%) used intravenous heparin, which was reversed routinely by 47/348 (13%) and selectively by 60/348 (17%).


CONCLUSIONS
There appears to be broad consensus between vascular surgeons in the pharmacological management of patients undergoing carotid endarterectomy, although some variations do exist. Further clinical studies may help clarify the optimum management strategy in this patient group.
Hamish
M
M
Imperial Vascular Unit, Charing Cross Hospital, London, UK.
Gohel
M S
MS
Shepherd
A
A
Howes
N J
NJ
Davies
A H
AH
D000925:Anticoagulants / Q000008:administration & dosage; D002317:Cardiovascular Agents / Q000008:administration & dosage*; D002340:Carotid Artery Diseases / Q000188:drug therapy* / Q000601:surgery*; D004334:Drug Administration Schedule; D004363:Drug Utilization; D016894:Endarterectomy, Carotid / Q000009:adverse effects / Q000706:statistics & numerical data; D005060:Europe; D019538:Health Care Surveys; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage; D020407:Internet; D019990:Perioperative Care; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage; D010818:Practice Patterns, Physicians' / Q000706:statistics & numerical data; D011795:Surveys and Questionnaires
D000925:Anticoagulants; D002317:Cardiovascular Agents; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D010975:Platelet Aggregation Inhibitors