title: Heavy silicone oil (Densiron-68) for the treatment of persistent macular holes: Densiron-68 endotamponade for persistent macular holes.
abstract: OBJECTIVE
  To evaluate the efficacy and safety of the use of Densiron-68 as intraocular endotamponade for the treatment of persisting macular holes (persistent MHs).
  
  
  METHODS
  Retrospective interventional case study on 23 consecutive eyes showing persistent MHs after unsuccessful primary surgery that underwent retreatment with pars plana vitrectomy and Densiron-68 filling. The main outcome measures were: anatomic closure evaluated with optical coherence tomography (OCT), final best-corrected visual acuity (BCVA), and postoperative complications.
  
  
  RESULTS
  A total of 23 patients (52-88 years) were studied. Pre-operative OCT showed full-thickness MH (mean size 560 microm) in all patients. Densiron-68 was left in situ for 1.5-3 months. Final follow-up time was 12 months after the last surgery. Postoperative OCT showed the complete closure of the PMH in 20 of 23 eyes. Pre-operative BCVA ranged from 20/200 to 20/630 (1.50-1.00 logMAR, mean 1.14). Final postoperative BCVA ranged from 20/30 to 20/400 (0.18-1.30 logMAR, mean. 0.61). Nineteen eyes (82%) showed a significant increase in visual acuity by at least three lines: 11 (47%) patients gained at least four lines. Three eyes remained unchanged (13%). One case deteriorated by two lines (4%). No major complications were recorded.
  
  
  CONCLUSIONS
  Retreatment with Densiron-68 filling was safe and achieved encouraging anatomic and functional results.
authors: Eye Surgery Clinic, Santa Chiara Hospital, Pisa, Italy. chiroftalmica@ao-pisa.toscana.it
authors: Stanislao
authors: S
authors: Rizzo
authors: Federica
authors: F
authors: Genovesi-Ebert
authors: Andrea
authors: A
authors: Vento
authors: Federica
authors: F
authors: Cresti
authors: Sofia
authors: S
authors: Miniaci
authors: Maria Chiara
authors: MC
authors: Romagnoli
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D012167:Retinal Perforations / Q000175:diagnosis / Q000188:drug therapy*; D019233:Retreatment; D012189:Retrospective Studies; D012827:Silicone Oils / Q000009:adverse effects / Q000627:therapeutic use*; D041623:Tomography, Optical Coherence; D016896:Treatment Outcome; D014792:Visual Acuity / Q000502:physiology; D014821:Vitrectomy
chemical_list: D012827:Silicone Oils; C539718:densiron-68