Electrohydrodynamics: A facile technique to fabricate drug delivery systems.
Electrospinning and electrospraying are facile electrohydrodynamic fabrication methods that can generate drug delivery systems (DDS) through a one-step process. The nanostructured fiber and particle morphologies produced by these techniques offer tunable release kinetics applicable to diverse biomedical applications. Coaxial electrospinning/electrospraying, a relatively new technique of fabricating core-shell fibers/particles have added to the versatility of these DDS by affording a near zero-order drug release kinetics, dampening of burst release, and applicability to a wider range of bioactive agents. Controllable electrospinning/spraying of fibers and particles and subsequent drug release from these chiefly polymeric vehicles depends on well-defined solution and process parameters. The additional drug delivery capability from electrospun fibers can further enhance the material's functionality in tissue engineering applications. This review discusses the state-of-the-art of using electrohydrodynamic technique to generate nanofiber/particles as drug delivery devices.
Chakraborty
Syandan
S
Biomedical Engineering Department, Duke University, Durham, NC 27708-0281, USA.
Liao
I-Chien
IC
Adler
Andrew
A
Leong
Kam W
KW
D004339:Drug Compounding / Q000295:instrumentation / Q000379:methods*; D016503:Drug Delivery Systems / Q000379:methods*; D004563:Electrochemistry; D008962:Models, Theoretical; D057139:Nanofibers / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D023822:Tissue Engineering
D004364:Pharmaceutical Preparations