title: Positron emission tomography for the detection of colorectal adenomas.
abstract: BACKGROUND
  (18)F-fluorodeoxyglucose ((18)F-FDG) positron emission tomography (PET) has been reported to detect colorectal adenomas.
  
  
  OBJECTIVE
  This study aimed at evaluating the sensitivity of (18)F-FDG PET with computed tomography image fusion (PET/CT) for detecting colorectal adenomas.
  
  
  METHODS
  We retrospectively compared the results of 92 (18)F-FDG PET/CT studies followed by colonoscopy. Colonoscopy and histology were considered as the gold standard.
  
  
  RESULTS
  One hundred fifty-seven lesions were observed. All the 12 malignancies were identified by (18)F-FDG PET/CT but only 27 out of 119 resected adenomas (sensitivity 22.7%) and none of the hyperplastic polyps were detected. At the univariate and multivariate analyses there was a significant statistical association between adenomas sized more than 10mm, presence of villous component and high-grade dysplasia and the ability of (18)F-FDG PET/CT to detect adenomas. (18)F-FDG PET/CT showed an overall sensitivity of 29.8%, a specificity of 81.1%, a positive predictive value (PPV) of 84.8% and a negative predictive value (NPV) of 24.6% for the neoplastic colorectal lesions globally considered.
  
  
  CONCLUSIONS
  (18)F-FDG PET/CT has a low sensitivity for detecting adenomas. However, because of the specificity and PPV of the technique for neoplastic colorectal lesions, the presence of a focal colorectal FDG uptake justifies the patient undergoing colonoscopy.
authors: European Institute of Oncology, Milan, Italy. davide.ravizza@ieo.it
authors: Davide
authors: D
authors: Ravizza
authors: Mirco
authors: M
authors: Bartolomei
authors: Luigi
authors: L
authors: Santoro
authors: Darina
authors: D
authors: Tamayo
authors: Giancarla
authors: G
authors: Fiori
authors: Cristina
authors: C
authors: Trovato
authors: Concetta
authors: C
authors: De Cicco
authors: Giuseppe
authors: G
authors: De Roberto
authors: Giovanni
authors: G
authors: Paganelli
authors: Cristiano
authors: C
authors: Crosta
mesh_terms: D000236:Adenoma / Q000000981:diagnostic imaging* / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D012189:Retrospective Studies; D012680:Sensitivity and Specificity
chemical_list: D019788:Fluorodeoxyglucose F18