Antibiotic effects on mitochondrial translation and in patients with mitochondrial translational defects.
The infantile presentation of mitochondrial respiratory chain defects frequently simulates acute bacterial infection and sepsis. Consequently, broad spectrum antibiotic therapy is often initiated before definitive diagnosis is reached and without taking into consideration the potential harm of antibiotics affecting mitochondrial translation. Here, we demonstrate that some commonly used translation-targeted antibiotics adversely affect the growth of fibroblasts from patients with defective mitochondrial translation systems. In addition, we show that these antibiotics inhibit mitochondrial translation in vitro. Our results suggest that patients with mitochondrial translation defects may be more vulnerable to toxic-side-effects following the administration of certain translation-targeted antibiotics.
Jones
Christie N
CN
Department of Chemistry, University of North Carolina, Chapel Hill, United States.
Miller
Chaya
C
Tenenbaum
Ariel
A
Spremulli
Linda L
LL
Saada
Ann
A
D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D005347:Fibroblasts / Q000187:drug effects; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008928:Mitochondria / Q000187:drug effects*; D024101:Mitochondrial Proteins / Q000096:biosynthesis*; D014176:Protein Biosynthesis / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D024101:Mitochondrial Proteins