title: Primary gastric T cell lymphoma mimicking marginal zone B cell lymphoma of mucosa-associated lymphoid tissue.
abstract: Primary gastric T cell lymphoma is rare and mostly of large cell type. In this paper, we present a case of gastric T cell lymphoma morphologically similar to the gastric marginal zone B cell lymphoma of mucosa-associated lymphoid tissue (MALT). Morphologically, the cells are small with abundant clear cytoplasm. Lymphoepithelial lesions are readily identified with diffuse destruction of gastric glands. Immunohistochemically, the neoplastic cells are CD3+/CD4+/CD8-/Granzyme B-. Molecular studies revealed monoclonal T cell receptor gamma gene rearrangement. Clinically, the patient responded initially to four cycles of R-CHOP, but then progressed. Because peripheral T cell lymphoma is usually associated with a poor prognosis, whereas marginal zone B cell lymphoma is an indolent lymphoproliferative disorder, this morphologic mimicry should be recognized and completely investigated when atypical small lymphoid infiltrates with lymphoepithelial lesions are encountered in the stomach.
authors: Department of Pathology, School of Medicine, University of Maryland, Baltimore, 22 South Greene Street, Room NBW78, Baltimore, MD, 21201, USA.
authors: Danniele
authors: D
authors: Holanda
authors: Merry Y
authors: MY
authors: Zhao
authors: Aaron P
authors: AP
authors: Rapoport
authors: Michael
authors: M
authors: Garofalo
authors: Qing
authors: Q
authors: Chen
authors: X Frank
authors: XF
authors: Zhao