Molecular genetic analysis of a primitive neuroectodermal tumor arising after intracranial radiation and chemotherapy for leukemia.
Primitive neuroectodermal tumors are aggressive tumors of the central nervous system (CNS), yet their etiology remains unclear. We report a case of a primitive neuroectodermal tumor (PNET) arising in the cerebellum and pons 7 yr after intracranial radiation and chemotherapy for leukemia involving the CNS. This case suggests a possible link between radiation, chemotherapy, and the formation of these tumors, with a potential new pathogenetic role for somatic inactivation of the protooncogene RET.
Johnson
Mahlon D
MD
Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Moots
Paul L
PL
Zhuang
Zhengping
Z
Weil
Robert J
RJ
D000328:Adult; D016026:Bone Marrow Transplantation; D001921:Brain / Q000473:pathology; D002879:Chromosomes, Human, Pair 10 / Q000235:genetics; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics; D016371:Cranial Irradiation / Q000009:adverse effects*; D006801:Humans; D019656:Loss of Heterozygosity / Q000235:genetics; D008279:Magnetic Resonance Imaging; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage / Q000627:therapeutic use; D018242:Neuroectodermal Tumors, Primitive / Q000209:etiology* / Q000235:genetics* / Q000473:pathology; D051059:PTEN Phosphohydrolase / Q000235:genetics; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy* / Q000532:radiotherapy* / Q000628:therapy; D051096:Proto-Oncogene Proteins c-ret / Q000235:genetics; D016159:Tumor Suppressor Protein p53 / Q000235:genetics; D014916:Whole-Body Irradiation
D016159:Tumor Suppressor Protein p53; D051096:Proto-Oncogene Proteins c-ret; C099282:RET protein, human; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human; D008727:Methotrexate