Beta-blockers post-MI: an example of age discrimination?
While beta-blockers have been demonstrated effective in many clinical trials of post-myocardial infarction patients, the trial populations have often excluded the elderly. Analysis of available data from older patients in large trials and results of smaller trials and retrospective studies suggest that benefit derived from beta-blocker therapy is not affected by age. Even though these data have limitations, beta-blocker therapy has been consistently associated with improved survival in all age groups, including patients older than 80 years. Underutilization of these drugs among the elderly is disconcerting given their benefit.
Gottlieb
Stephen
S
Department of Cardiology, University of Maryland Medical Center, Baltimore, MD 21201, USA. sgottlie@medicine.umaryland.edu
D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D004305:Dose-Response Relationship, Drug; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D009203:Myocardial Infarction / Q000188:drug therapy*; D011287:Prejudice; D012189:Retrospective Studies; D013997:Time Factors
D000319:Adrenergic beta-Antagonists