title: [Deep non-reactive reversible coma after a Mediterranean neurotoxic fish poisoning].
abstract: BACKGROUND
  Neurotoxic fish poisoning appears to be a recent phenomenon in the Mediterranean Sea. We report a case of deep non-reactive reversible coma after ingestion of Mediterranean fish innards.
  
  
  METHODS
  An 80 year-old man, heavy smoker who had a previous cerebral infarct in the posterior territory, was admitted for rapid deterioration of his neurological condition. He started having perioral tingling, then dysarthria, then became quadriparetic, then developed respiratory and hemodynamic failure and within 3-4h, entered a state of deep non-reactive coma with absence of all brainstem reflexes. He started to improve after 20 h and recovered his neurological baseline within 36 h. Later on, he stated that all his symptoms started after he ingested the gonads of a toxic fish, Lagocephalus scleratus.
  
  
  CONCLUSIONS
  Tetrodotoxin blocks voltage-gated sodium channels and inhibits the production and propagation of action potentials. This toxin is highly concentrated in the liver, gonads, intestines and skin of this fish that is well-known in Japan (where it is considered as a delicacy) and South-East Asia and seems to have migrated recently to the Mediterranean Sea. There is no known antidote to tetrodotoxin but intensive supportive treatment can be life-saving.
authors: Service de neurologie, Hôtel-Dieu de France, Achrafieh, Beyrouth, Liban. awadaadnan@yahoo.com
authors: A
authors: A
authors: Awada
authors: V
authors: V
authors: Chalhoub
authors: L
authors: L
authors: Awada
authors: P
authors: P
authors: Yazbeck
mesh_terms: D000369:Aged, 80 and over; D000818:Animals; D001933:Brain Stem / Q000502:physiology; D002544:Cerebral Infarction / Q000209:etiology; D003128:Coma / Q000139:chemically induced* / Q000209:etiology*; D005260:Female; D005517:Foodborne Diseases / Q000150:complications*; D006801:Humans; D008297:Male; D008460:Meat; D008522:Mediterranean Sea; D009460:Neurologic Examination; D020258:Neurotoxicity Syndromes / Q000150:complications*; D010053:Ovary / Q000737:chemistry; D011782:Quadriplegia / Q000209:etiology; D012907:Smoking / Q000009:adverse effects; D023721:Tetraodontiformes; D013779:Tetrodotoxin / Q000506:poisoning*
chemical_list: D013779:Tetrodotoxin