title: [Effects of quercetin on the expression of VEGF-C and VEGFR-3 in human cancer MGC-803 cells].
abstract: OBJECTIVE
  To investigate the mechanism of quercetin on the inhibition of the lymphatic metastasis in human gastric cancer cells MGC-803.
  
  
  METHODS
  Cells were divided into the control group and the quercetin (Que)-treated group. Immunohistochemistry and RT-PCR were used to detect the expression of vascular endothelial growth factor C (VEGF-C) and VEGFR-3 of human gastric cancer cells MGC-803 in response to Que.
  
  
  RESULTS
  Que significantly decreased the expression of VEGF-C and VEGFR-3 at 40 mumol/L compared with the control group after 48 h (P<0.01).
  
  
  CONCLUSIONS
  Que can down-regulate the expression of VEGF-C and VEGFR-3 in human gastric cancer cells MGC-803.
authors: Institute of Cellular and Molecular Biology, College of Medical Science, Wuhan University of Science and Technology, Wuhan 430065, China.
authors: Zhi-jun
authors: ZJ
authors: Yu
authors: Li-ya
authors: LY
authors: He
authors: Yong
authors: Y
authors: Chen
authors: Mian-yun
authors: MY
authors: Wu
authors: Xue-hua
authors: XH
authors: Zhao
authors: Zhen-yu
authors: ZY
authors: Wang
mesh_terms: D045744:Cell Line, Tumor; D015536:Down-Regulation / Q000187:drug effects*; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D006801:Humans; D011794:Quercetin / Q000494:pharmacology*; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism; D042582:Vascular Endothelial Growth Factor C / Q000235:genetics* / Q000378:metabolism; D040321:Vascular Endothelial Growth Factor Receptor-3 / Q000235:genetics* / Q000378:metabolism
chemical_list: D042582:Vascular Endothelial Growth Factor C; D011794:Quercetin; D040321:Vascular Endothelial Growth Factor Receptor-3