[Effect of Cynomorium songaricum polysaccharide on telomere length in blood and brain of D-galactose-induced senescence mice].
OBJECTIVE
To study the effects of Cynomorium songaricum polysaccharide (CSP) on telomere length in blood and brain tissues of aged mice in order to provide some evidence for CSP's development and applying in the clinical uses.


METHODS
Kunming mice were intraperitoneal injected D-galactose (500 mg x kg(-1) x d(-1)) to make the aging models, and different dosages of CSP (20, 40, 80 mg x kg(-1)) were given by gavage for 56 days. The average length of telomere was determined by real-time fluorescence quantitative PCR.


RESULTS
The relative T/S ratio of the group high and middle dosages of CSP in blood were 1.64 +/- 0.36 and 1.33 +/0.28, respectively, and higher than that of the group of senescence 1.01 +/- 0.13 (P < 0.01). Values of the group of high, middle, and low dosages of CSP in brain tissues were 3.34 +/- 0.58, 2.30 +/- 0. 75 and 1.55 +/- 0.58, respectively, and significantly higher than that of the group of senescence 1.04 +/- 0.33 (P < 0.01).


CONCLUSIONS
CSP can exert the anti-aging effects by increase telomere length f senescence mice.
Ma
Lijie
L
College of Life Science, Inner Mongolia University, Hohhot 010021, China.
Chen
Guilin
G
Nie
Lisha
L
Ai
Min
M
D000375:Aging / Q000187:drug effects*; D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000187:drug effects / Q000473:pathology; D016922:Cellular Senescence / Q000187:drug effects; D031482:Cynomorium / Q000737:chemistry*; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005690:Galactose / Q000494:pharmacology; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D051379:Mice; D011134:Polysaccharides / Q000494:pharmacology / Q000627:therapeutic use; D016615:Telomere / Q000187:drug effects* / Q000502:physiology
D004365:Drugs, Chinese Herbal; D011134:Polysaccharides; D005690:Galactose