[New mechanisms by which physical exercise improves insulin resistance in the skeletal muscle].
Insulin resistance of skeletal muscle glucose transport is a key-defect for the development of impaired glucose tolerance and type 2 diabetes. However, it is known that both an acute bout of exercise and chronic endurance exercise training can bring beneficial effects on insulin action in insulin-resistant states. However, little is currently known about the molecular effects of acute exercise on muscle insulin signaling in the post-exercise state in insulin-resistant organisms. This review provides new insight into the mechanism through which acute exercise restores insulin sensitivity, highlighting an important role for inflammatory proteins and S-nitrosation in the regulation of insulin signaling proteins in skeletal muscle.
Pauli
José Rodrigo
JR
Departamento de Biociências, Faculdade de Educação Física, modalidade Saúde, Universidade Federal de São Paulo, Santos, SP, Brasil. rodrigosere@yahoo.com.br
Cintra
Dennys Esper
DE
Souza
Claudio Teodoro de
CT
Ropelle
Eduardo Rochette
ER
D015444:Exercise / Q000502:physiology*; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D055504:Insulin Receptor Substrate Proteins / Q000378:metabolism; D007333:Insulin Resistance / Q000502:physiology*; D018482:Muscle, Skeletal / Q000378:metabolism*; D009566:Nitrates / Q000378:metabolism; D015538:Nitrosation; D015398:Signal Transduction / Q000502:physiology*
D055504:Insulin Receptor Substrate Proteins; D009566:Nitrates; D005947:Glucose