Natural products-based insecticidal agents 4. Semisynthesis and insecticidal activity of novel esters of 2-chloropodophyllotoxin against Mythimna separata Walker in vivo.
By using podophyllotoxin as a lead compound, eight novel esters of 2-chloropodophyllotoxin were designed, semisynthesized, and preliminarily evaluated for their insecticidal activity against the pre-third-instar larvae of Mythimna separata Walker in vivo for the first time. Among all the tested compounds, especially three esters of 2-chloropodophyllotoxin 8a, 8c, and 8g, and one intermediate 6 showed more promising and pronounced insecticidal activity than toosendanin, a commercial insecticide derived from Melia azedarach.
Xu
Hui
H
Laboratory of Pharmaceutical Design and Synthesis, College of Life Sciences, Northwest A&F University, Yangling 712100, China. orgxuhui@nwsuaf.edu.cn
Xiao
Xiao
X
D000818:Animals; D018360:Crystallography, X-Ray; D004952:Esters / Q000737:chemistry; D007306:Insecticides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D007814:Larva / Q000187:drug effects; D008958:Models, Molecular; D009036:Moths / Q000187:drug effects*; D011034:Podophyllotoxin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*; D011035:Podophyllum / Q000737:chemistry; D013329:Structure-Activity Relationship
D004952:Esters; D007306:Insecticides; D011034:Podophyllotoxin