Hepatitis C virus utilizes lipid droplet for production of infectious virus.
Hepatitis C virus (HCV) establishes a persistent infection and causes chronic hepatitis. Chronic hepatitis patients often develop hepatic cirrhosis and progress to liver cancer. The development of this pathological condition is linked to the persistent infection of the virus. In other words, viral replication/multiplication may contribute to disease pathology. Accumulating clinical studies suggest that HCV infection alters lipid metabolism, and thus causes fatty liver. It has been reported that this abnormal metabolism exacerbates hepatic diseases. Recently, we revealed that lipid droplets play a key role in HCV replication. Understanding the molecular mechanism of HCV replication will help elucidate the pathogenic mechanism and develop preventive measures that inhibit disease manifestation by blocking persistent infection. In this review, we outline recent findings on the function of lipid droplets in the HCV replication cycle and describe the relationship between the development of liver diseases and virus replication.
Ogawa
Kazuya
K
Research Institute, Chiba Institute of Technology, Chiba, Japan.
Hishiki
Takayuki
T
Shimizu
Yuko
Y
Funami
Kenji
K
Sugiyama
Kazuo
K
Miyanari
Yusuke
Y
Shimotohno
Kunitada
K
D000818:Animals; D002477:Cells / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D003902:Detergents / Q000494:pharmacology; D016174:Hepacivirus / Q000187:drug effects / Q000235:genetics / Q000254:growth & development / Q000502:physiology*; D006801:Humans; D050356:Lipid Metabolism / Q000187:drug effects / Q000502:physiology*; D014764:Viral Proteins / Q000737:chemistry / Q000378:metabolism; D014779:Virus Replication / Q000187:drug effects / Q000502:physiology*
D003902:Detergents; D014764:Viral Proteins