Characterization of liposomes for cancer cell transfection.
We have characterized a broad range of liposome formulations with varying DcChol:DOPE ratio. Subsequent addition of DcChol to liposomes increases its positive surface charge. However, loading the nuclear acids did not neutralize the overall negative surface potential to a similar extent. The liposomes were tested by transfection of DNA in living cancer cells.
Tatarkova
Svetlana A
SA
Department of Physics, Durham University, South Road, Durham, DH1 3LE, UK.
Khaira
Satvinder
S