Cardiovascular complications of diabetes mellitus: The Tissue Factor perspective.
Heightened activity of circulating Tissue Factor (TF) has been linked to a variety of macro- and microvascular cardiovascular complications commonly observed in diabetes mellitus. Systemic and localized vascular abnormalities comprise the most debilitating feature of diabetic pathophysiology. Blood monocytes are chronically activated in diabetes, and serve as the major source of bioactive intravascular TF. This review examines recent literature on this subject, with a special emphasis on the abnormal monocyte physiology in diabetes and the structural and functional diversity of circulating TF.
Bogdanov
Vladimir Y
VY
Division of Hematology/Oncology, University of Cincinnati College of Medicine, Cincinnati, OH, USA. Vladimir.Bogdanov@uc.edu
Osterud
Bjarne
B
D002318:Cardiovascular Diseases / Q000097:blood*; D048909:Diabetes Complications / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications*; D006801:Humans; D013925:Thromboplastin / Q000378:metabolism*
D013925:Thromboplastin