Regulation of thrombin activity with a bifunctional aptamer and hemin: development of a new anticoagulant and antidote pair.
Wang
Jing
J
Department of Biochemistry and National Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, China.
Cao
Ya
Y
Chen
Guifang
G
Li
Genxi
G
D000925:Anticoagulants / Q000737:chemistry* / Q000378:metabolism; D000931:Antidotes / Q000737:chemistry* / Q000378:metabolism; D052157:Aptamers, Nucleotide / Q000737:chemistry* / Q000378:metabolism; D002942:Circular Dichroism; D006427:Hemin / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D013056:Spectrophotometry, Ultraviolet; D013917:Thrombin / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013918:Thrombin Time
D000925:Anticoagulants; D000931:Antidotes; D052157:Aptamers, Nucleotide; C081676:thrombin aptamer; D006427:Hemin; D013917:Thrombin