title: Facile synthesis of N-glycosyl amides using a N-glycosyl-2,4-dinitrobenzenesulfonamide and thioacids.
abstract: N-Glucosyl-2,4-dinitrobenzenesulfonamide was prepared from N-acetyl-d-glucosamine and 2,4-dinitrobenzenesulfonyl chloride. Amidation of several thioacids using the N-glucosylsulfonamide donor proceeded smoothly to give the desired N-glucosylamides in good to high yields. The amidation reactions were carried out at room temperature, under mild conditions, and were completed in a very short time.
authors: Department of Chemistry, The University of Toledo, OH 43606, United States.
authors: Rommel S
authors: RS
authors: Talan
authors: Aditya K
authors: AK
authors: Sanki
authors: Steven J
authors: SJ
authors: Sucheck
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D006027:Glycosides / Q000138:chemical synthesis* / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013438:Sulfhydryl Compounds / Q000737:chemistry*
chemical_list: D000577:Amides; D006027:Glycosides; D013438:Sulfhydryl Compounds