title: [Effect of paeonol on protecting endothelial cells of diabetic rats].
abstract: OBJECTIVE
  To study the effect of paeonol on protecting endothelial cells of diabetic rats.
  
  
  METHODS
  Streptozocin was used on rats to make diabetic models. Different dosages of paeonol were fed on all the model rats. PGI, TXA2, ET, CRP, ICAM-1, VCAM-1 and NO were tested after 30 day's therapy.
  
  
  RESULTS
  Compared with control group PGI increased from 89.75 +/- 2.75, 89.97 +/- 7.28, 89.97 +/- 11.36 to 120.03 +/- 13.85, 108.34 +/- 11.25, 105.32 +/- 8.85, respectively. TXA2 decreased from 157.64 +/- 10.36, 156.64 +/- 11.35, 153.33 +/- 19.40 to 124.46 +/- 18.67, 136.40 +/- 18.15, 138.40 +/- 22.20, respectively. ET decreased from 181.68 +/- 5.10, 181.27 +/- 4.76, 181.04 +/- 4.19 to 140.55 +/- 3.01, 150.51 +/- 2.22, 161.02 +/- 3.76, respectively. CRP decreased from 41.63 +/- 7.37, 44.83 +/- 7.80, 42.06 +/- 7.21 to 28.62 +/- 5.45, 30.00 +/- 10.73, 37.09 +/- 4.94, respectively. ICAM-1 decreased from 225.77 +/- 11.96, 222.78 +/- 14.46, 225.17 +/- 10.03 to 190.93 +/- 12.67, 197.42 +/- 14.56, 200.64 +/- 15.36, respectively. VCAM-1 decreased from 566.72 +/- 24.46, 560.61 +/- 25.67, 359.61 +/- 42.75 to 506.26 +/- 37.26, 516.83 +/- 28.17, 527.02 +/- 43.47, respectively. NO had no change.
  
  
  CONCLUSIONS
  Paeonol can protect the endothelial cells of diabetic rats.
authors: Guangdong Provincial People's Hospital, Guangzhou 510080, China. drmincunyun888@yahoo.com.cn
authors: Cun-Yun
authors: CY
authors: Min
authors: He-Qiang
authors: HQ
authors: Liu
authors: Feng
authors: F
authors: Zhan
authors: Wei-Zhong
authors: WZ
authors: Qiu
mesh_terms: D000098:Acetophenones / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000139:chemically induced / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology*; D042783:Endothelial Cells / Q000187:drug effects*; D016232:Endothelins / Q000097:blood; D004730:Endothelium, Vascular / Q000166:cytology; D004797:Enzyme-Linked Immunosorbent Assay; D011464:Epoprostenol / Q000097:blood; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood; D008297:Male; D009569:Nitric Oxide / Q000097:blood; D029596:Paeonia / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013928:Thromboxane A2 / Q000097:blood
chemical_list: D000098:Acetophenones; D004365:Drugs, Chinese Herbal; D016232:Endothelins; D018799:Intercellular Adhesion Molecule-1; D009569:Nitric Oxide; C013638:paeonol; D013928:Thromboxane A2; D011464:Epoprostenol