Biomimetic doxorubicin loaded polymersomes from hyaluronan-block-poly(gamma-benzyl glutamate) copolymers.
Using "click chemistry" as an easy and versatile synthetic strategy to combine hyaluronan and polyglutamate blocks, we have prepared nanovesicles (polymersomes) that present a controlled size, excellent colloidal stability, and a high loading capacity for hydrophilic and hydrophobic drugs. The unique feature of our concept is the use of hyaluronan, a polysaccharide with known capacity for targeting cancer-related protein receptors, as the hydrophilic portion of a block copolymer system. The cytotoxicity and internalization mechanism of doxorubicin-loaded polymersomes have been evaluated in C6 glioma tumor cell lines. The dual purpose served by hyaluronan, as both a hydrophilic block critical to vesicle formation and a binding agent for biological targets, breaks new ground in terms of multifunctional nanomaterial design for drug delivery.
Upadhyay
K Kumar
KK
Université de Bordeaux, UMR5629, ENSCPB, Pessac-Cedex, France.
Le Meins
J-F
JF
Misra
A
A
Voisin
P
P
Bouchaud
V
V
Ibarboure
E
E
Schatz
C
C
Lecommandoux
S
S
D000970:Antineoplastic Agents / Q000737:chemistry*; D001932:Brain Neoplasms / Q000473:pathology; D045744:Cell Line, Tumor; D004317:Doxorubicin / Q000737:chemistry*; D005910:Glioma / Q000473:pathology; D006801:Humans; D006820:Hyaluronic Acid / Q000737:chemistry*; D018716:Molecular Mimicry; D011099:Polyglutamic Acid / Q000031:analogs & derivatives* / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*
D000970:Antineoplastic Agents; D011108:Polymers; C003172:poly-gamma-benzyl-L-glutamate; D011099:Polyglutamic Acid; D004317:Doxorubicin; D006820:Hyaluronic Acid