Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer.
We conducted a two-stage genome-wide association study of pancreatic cancer, a cancer with one of the lowest survival rates worldwide. We genotyped 558,542 SNPs in 1,896 individuals with pancreatic cancer and 1,939 controls drawn from 12 prospective cohorts plus one hospital-based case-control study. We conducted a combined analysis of these groups plus an additional 2,457 affected individuals and 2,654 controls from eight case-control studies, adjusting for study, sex, ancestry and five principal components. We identified an association between a locus on 9q34 and pancreatic cancer marked by the SNP rs505922 (combined P = 5.37 x 10(-8); multiplicative per-allele odds ratio 1.20; 95% confidence interval 1.12-1.28). This SNP maps to the first intron of the ABO blood group gene. Our results are consistent with earlier epidemiologic evidence suggesting that people with blood group O may have a lower risk of pancreatic cancer than those with groups A or B.
Amundadottir
Laufey
L
Kraft
Peter
P
Stolzenberg-Solomon
Rachael Z
RZ
Fuchs
Charles S
CS
Petersen
Gloria M
GM
Arslan
Alan A
AA
Bueno-de-Mesquita
H Bas
HB
Gross
Myron
M
Helzlsouer
Kathy
K
Jacobs
Eric J
EJ
LaCroix
Andrea
A
Zheng
Wei
W
Albanes
Demetrius
D
Bamlet
William
W
Berg
Christine D
CD
Berrino
Franco
F
Bingham
Sheila
S
Buring
Julie E
JE
Bracci
Paige M
PM
Canzian
Federico
F
Clavel-Chapelon
Françoise
F
Clipp
Sandra
S
Cotterchio
Michelle
M
de Andrade
Mariza
M
Duell
Eric J
EJ
Fox
John W
JW
Gallinger
Steven
S
Gaziano
J Michael
JM
Giovannucci
Edward L
EL
Goggins
Michael
M
González
Carlos A
CA
Hallmans
Göran
G
Hankinson
Susan E
SE
Hassan
Manal
M
Holly
Elizabeth A
EA
Hunter
David J
DJ
Hutchinson
Amy
A
Jackson
Rebecca
R
Jacobs
Kevin B
KB
Jenab
Mazda
M
Kaaks
Rudolf
R
Klein
Alison P
AP
Kooperberg
Charles
C
Kurtz
Robert C
RC
Li
Donghui
D
Lynch
Shannon M
SM
Mandelson
Margaret
M
McWilliams
Robert R
RR
Mendelsohn
Julie B
JB
Michaud
Dominique S
DS
Olson
Sara H
SH
Overvad
Kim
K
Patel
Alpa V
AV
Peeters
Petra H M
PH
Rajkovic
Aleksandar
A
Riboli
Elio
E
Risch
Harvey A
HA
Shu
Xiao-Ou
XO
Thomas
Gilles
G
Tobias
Geoffrey S
GS
Trichopoulos
Dimitrios
D
Van Den Eeden
Stephen K
SK
Virtamo
Jarmo
J
Wactawski-Wende
Jean
J
Wolpin
Brian M
BM
Yu
Herbert
H
Yu
Kai
K
Zeleniuch-Jacquotte
Anne
A
Chanock
Stephen J
SJ
Hartge
Patricia
P
Hoover
Robert N
RN
D000017:ABO Blood-Group System / Q000235:genetics*; D000483:Alleles; D016022:Case-Control Studies; D002899:Chromosomes, Human, Pair 9; D015331:Cohort Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D055106:Genome-Wide Association Study; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D007438:Introns; D015810:Linkage Disequilibrium; D016015:Logistic Models; D008297:Male; D016017:Odds Ratio; D010190:Pancreatic Neoplasms / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011446:Prospective Studies; D012307:Risk Factors; D014481:United States
D000017:ABO Blood-Group System