The absorption characteristics of bifendate solid dispersion in rat intestinal tissue.
OBJECTIVE
Research on bifendate intestinal absorption.


METHODS
The single passed intestinal backflow method was used. Bifendate with different concentrations, bifendate with and without 2,4-dinitrophenol, verapamil, and probenecid, and solid state of bifendate in different systems were studied.


RESULTS
Change of concentration and the presence of energy inhibitor, P-glycoprotein inhibitor and multidrug-resistant protein inhibitor did not affect the K(a) of bifendate intestinal absorption; there were obvious differences among intestinal absorption of native drug, solid dispersion, and physical mixtures.


CONCLUSIONS
The result indicated that the intestinal absorption mechanism of bifendate is passive transport. Solid state of bifendate in different systems could affect the intestinal absorption.
Cheng
Juan
J
Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing, PR China.
Wu
Zheng Hong
ZH
Ping
Qineng Neng
QN
Wang
Bogang
B
Lu
Junjun
J
D018435:ATP Binding Cassette Transporter, Subfamily B / Q000037:antagonists & inhibitors / Q000502:physiology; D000327:Adsorption; D000465:Algorithms; D000818:Animals; D001713:Biphenyl Compounds / Q000008:administration & dosage / Q000032:analysis / Q000097:blood / Q000493:pharmacokinetics*; D004355:Drug Stability; D004734:Energy Metabolism / Q000187:drug effects / Q000502:physiology; D006207:Half-Life; D007408:Intestinal Absorption / Q000187:drug effects; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000187:drug effects; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000037:antagonists & inhibitors / Q000502:physiology; D009928:Organ Specificity; D010592:Pharmaceutic Aids / Q000737:chemistry; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012995:Solubility; D013535:Suspensions; D013997:Time Factors; D014475:Uncoupling Agents / Q000494:pharmacology
D018435:ATP Binding Cassette Transporter, Subfamily B; D001713:Biphenyl Compounds; D027425:ATP-Binding Cassette, Sub-Family C Proteins; D010592:Pharmaceutic Aids; D013535:Suspensions; D014475:Uncoupling Agents; C465548:bifendate