title: Effect of treatment on weight gain and metabolic abnormalities in patients with first-episode psychosis.
abstract: OBJECTIVE
  The aim of the present prospective and naturalistic study was to examine the effects of antipsychotic medication on weight and serum levels of lipids, glucose and insulin in first-episode psychosis patients.
  
  
  METHODS
  Fifty-six patients admitted to the Singapore Early Psychosis Intervention Programme participated in this study. They were assessed at baseline (i.e. within 72 h of starting antipsychotics), and 6 months later. Weight (kg) and height (m) were measured and body mass index (BMI) was calculated. Blood samples were taken after a 12 h overnight fast. Choice of antipsychotics was based on the treating physician's clinical decision. Total cumulative Chlorpromazine (CPZ) equivalent of antipsychotic exposure during the 6 months was calculated. Statistical analyses were carried out for comparisons between baseline and 6 months, and for the two outcome event groups of > or =7% versus <7% weight gain. Where appropriate, confounders were controlled.
  
  
  CONCLUSIONS
  There were significant increases in BMI, serum levels of triglyceride, low-density lipoprotein and total cholesterol from baseline to 6 months. Mean increase in weight was 6.2+/-7.0 kg (p < 0.05) and 65% of the patients had clinically significant weight gain (i.e. > or =7% increase from baseline). On logistic regression lower baseline BMI, female gender, and younger age, were associated with clinically significant weight gain.
authors: Early Psychosis Intervention Programme, Institute of Mental Health/Woodbridge Hospital, 10 Buangkok View, Singapore. swapna_verma@imh.com.sg
authors: Swapna
authors: S
authors: Verma
authors: Alvin
authors: A
authors: Liew
authors: Mythily
authors: M
authors: Subramaniam
authors: Lye Yin
authors: LY
authors: Poon
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D014150:Antipsychotic Agents / Q000009:adverse effects*; D001786:Blood Glucose / Q000187:drug effects; D015992:Body Mass Index; D015331:Cohort Studies; D050171:Dyslipidemias / Q000139:chemically induced*; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D011618:Psychotic Disorders / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism*; D012727:Sex Characteristics; D015430:Weight Gain / Q000187:drug effects*
chemical_list: D014150:Antipsychotic Agents; D001786:Blood Glucose; D007328:Insulin