Glycemic control in youth with diabetes: the SEARCH for diabetes in Youth Study.
OBJECTIVE
To assess correlates of glycemic control in a diverse population of children and youth with diabetes.


METHODS
This was a cross-sectional analysis of data from a 6-center US study of diabetes in youth, including 3947 individuals with type 1 diabetes (T1D) and 552 with type 2 diabetes (T2D), using hemoglobin A(1c) (HbA(1c)) levels to assess glycemic control.


RESULTS
HbA(1c) levels reflecting poor glycemic control (HbA(1c) >or= 9.5%) were found in 17% of youth with T1D and in 27% of those with T2D. African-American, American Indian, Hispanic, and Asian/Pacific Islander youth with T1D were significantly more likely to have higher HbA(1c) levels compared with non-Hispanic white youth (with respective rates for poor glycemic control of 36%, 52%, 27%, and 26% vs 12%). Similarly poor control in these 4 racial/ethnic groups was found in youth with T2D. Longer duration of diabetes was significantly associated with poorer glycemic control in youth with T1D and T2D.


CONCLUSIONS
The high percentage of US youth with HbA(1c) levels above the target value and with poor glycemic control indicates an urgent need for effective treatment strategies to improve metabolic status in youth with diabetes.
Petitti
Diana B
DB
Biomedical Informatics, Arizona State University, Phoenix, AZ, USA.
Klingensmith
Georgeanna J
GJ
Bell
Ronny A
RA
Andrews
Jeanette S
JS
Dabelea
Dana
D
Imperatore
Giuseppina
G
Marcovina
Santica
S
Pihoker
Catherine
C
Standiford
Debra
D
Waitzfelder
Beth
B
Mayer-Davis
Elizabeth
E
D000293:Adolescent; D000704:Analysis of Variance; D001786:Blood Glucose / Q000032:analysis / Q000187:drug effects / Q000378:metabolism*; D015992:Body Mass Index; D002648:Child; D003430:Cross-Sectional Studies; D048909:Diabetes Complications / Q000517:prevention & control; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy* / Q000208:ethnology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy* / Q000208:ethnology; D005006:Ethnicity / Q000706:statistics & numerical data; D005260:Female; D005500:Follow-Up Studies; D006442:Glycated Hemoglobin / Q000032:analysis*; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D015994:Incidence; D016014:Linear Models; D008297:Male; D015999:Multivariate Analysis; D011336:Probability; D012042:Registries; D018570:Risk Assessment; D012720:Severity of Illness Index; D014481:United States; D055815:Young Adult
D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents