title: Circadian cardiac autonomic function in perinatally HIV-infected preschool children.
abstract: The 24-h heart rate variability and QT-interval adaptation was investigated in perinatally HIV-infected preschool children classified according to immunological status in order to assess autonomic function at early stages of infection. Thirty-five perinatally HIV-infected and clinically stable children (4.8 +/- 0.3 years) were enrolled after approval of the study by the University Hospital Pedro Ernesto Ethics Committee and written informed parental consent was obtained. The children were classified according to peripheral CD4+ count (cells/microL) as follows: group 1, N = 11 (>or=1000); group 2, N = 7 (>or=500 and <1000); group 3, N = 17 (<500). Left ventricular ejection fraction (>55%), 24-h RR interval variability (RRV) indexes (NN, SDANN, SDNN index, r-MSSD) and 24-h QT and Bazett-corrected QT (QTc) were determined, and groups were matched for age, body surface area, and left ventricular ejection fraction, reducing biases in RRV. The peak differences () between the highest and lowest RRV and QT indexes were extracted from nocturnal (1 am-6 am) and daytime (1 pm-6 pm) hourly assessed segments, respectively. Pearsons correlation (r) and Kruskal-Wallis ANOVA were used to compare groups. CD4+ count correlated positively with NN (r = 0.45; P = 0.003). There were no significant differences in daytime NN among groups. Nighttime SDNN index (P = 0.01), nighttime r-MSSD (P = 0.003), NN (P = 0.01), SDNN index (P = 0.03) and r-MSSD (P = 0.004) were significantly lower in group 3 than in the other groups. Expected nighttime QTc-interval lengthening was not observed in all groups. In perinatally HIV-infected preschool children with preserved left ventricular systolic function, parasympathetic-mediated autonomic dysfunction parallels immune status, impairing both RRV and circadian QTc interval adaptation.
authors: Serviço de Cardiologia, Universidade do Estado do Rio de Janeiro, Serviço de Cardiologia, Corpo de Bombeiros Militar do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brasil. ecgar@yahoo.com
authors: P R
authors: PR
authors: Benchimol-Barbosa
mesh_terms: D001341:Autonomic Nervous System / Q000276:immunology / Q000503:physiopathology*; D016516:CD4-CD8 Ratio; D002675:Child, Preschool; D002940:Circadian Rhythm / Q000276:immunology / Q000502:physiology*; D003430:Cross-Sectional Studies; D015716:Electrocardiography, Ambulatory; D005260:Female; D015658:HIV Infections / Q000276:immunology / Q000503:physiopathology*; D006329:Heart Conduction System / Q000276:immunology / Q000503:physiopathology*; D006339:Heart Rate / Q000276:immunology / Q000502:physiology*; D006801:Humans; D008297:Male; D019562:Viral Load