Haplofungins, new inositol phosphorylceramide synthase inhibitors, from Lauriomyces bellulus SANK 26899 II. Structure elucidation.
Eight new inositol phosphorylceramide synthase inhibitors: haplofungin A, B, C, D, E, F, G and H, were discovered in a culture broth of the fungus Lauriomyces bellulus SANK 26899. The planar structures for these haplofungins were elucidated by various spectroscopic analyses and a GC/MS analysis of their degradation products. All eight compounds were found to comprise an arabinonic acid moiety linked through an ester bond to a modified long alkyl chain.
Ohnuki
Takashi
T
Exploratory Research Laboratories I, Daiichi Sankyo Co. Ltd, Hiromachi, Shinagawa-ku, Tokyo, Japan. ohnuki.takashi.eh@daiichisankyo.co.jp
Yano
Tatsuya
T
Takatsu
Toshio
T
D001203:Ascomycota / Q000254:growth & development / Q000378:metabolism*; D002627:Chemistry, Physical; D003470:Culture Media; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000378:metabolism; D008401:Gas Chromatography-Mass Spectrometry; D006602:Hexosyltransferases / Q000037:antagonists & inhibitors*; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation
D003470:Culture Media; D004791:Enzyme Inhibitors; D006602:Hexosyltransferases; C088714:phosphatidylinositol-ceramide phosphoinositol transferase