title: Serum levels of 5-s-cysteinyldopa are correlated with skin colors in hemodialysis patients but not in peritoneal dialysis patients.
abstract: BACKGROUND
  Diffuse hyperpigmentation is common in patients with chronic renal failure undergoing hemodialysis (HD) or peritoneal dialysis (PD). We previously reported that serum levels of 5-S-cysteinyldopa (5SCD, a pheomelanin precursor) and pheomelanin were significantly elevated in HD patients.
  
  
  METHODS
  Skin color was assessed using a Mexameter that measures the melanin index (MI) and the erythema index (EI). The upper inner arms (non-sun-exposed site) and the foreheads (sun-exposed site) of HD and PD patients and control subjects were analyzed.
  
  
  RESULTS
  MI values on the upper inner arms and on the foreheads of HD and PD patients were significantly higher than in controls. In HD patients, significant correlations were found for serum 5SCD levels with MI and EI on the upper inner arm, and for EI on the forehead. In PD patients, no such correlations were found.
  
  
  CONCLUSIONS
  Hyperpigmentation in HD patients results partly from accumulation of pheomelanin in the skin.
authors: Department of Nephrology, Fujita Health University School of Medicine, Toyoake, Japan.
authors: Kazutaka
authors: K
authors: Murakami
authors: Yukiko
authors: Y
authors: Nakanishi
authors: Kazumasa
authors: K
authors: Wakamatsu
authors: Koichiro
authors: K
authors: Yamamoto
authors: Nahoko
authors: N
authors: Kohriyama
authors: Midori
authors: M
authors: Hasegawa
authors: Makoto
authors: M
authors: Tomita
authors: Kunihiro
authors: K
authors: Nabeshima
authors: Yoshiyuki
authors: Y
authors: Hiki
authors: Shinsuke
authors: S
authors: Asano
authors: Shiro
authors: S
authors: Kawashima
authors: Yasuhiro
authors: Y
authors: Ito
authors: Yoshiro
authors: Y
authors: Fujita
authors: Hiroaki
authors: H
authors: Asada
authors: Shigeru
authors: S
authors: Nakai
authors: Satoshi
authors: S
authors: Sugiyama
authors: Shosuke
authors: S
authors: Ito
mesh_terms: D000368:Aged; D003548:Cysteinyldopa / Q000097:blood*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood*; D008297:Male; D008543:Melanins / Q000097:blood*; D008875:Middle Aged; D010530:Peritoneal Dialysis; D006435:Renal Dialysis; D012880:Skin Pigmentation
chemical_list: D008543:Melanins; C018362:pheomelanin; D003548:Cysteinyldopa