Eosinophil-associated gastrointestinal disorders with asthma: immunohistochemical analyses.
We report 5 patients with eosinophil-associated gastrointestinal disorders (EGIDs) and asthma. All patients developed EGIDs while asthma remained clinically stable. Asthma severity was moderate persistent and severe persistent and 2 patients had intolerance to nonsteroidal anti-inflammatory drugs. By immunohistochemical analysis of the mucosa, eosinophils, macrophages, and T cells were found to be the major infiltrating cells. There was a lesser degree of infiltration of mast cells and B cells but no neutrophils. Compared with normal controls, increased counts of eosinophils and CD8+ T cells were found in the duodenum, and eosinophils, macrophages, and CD4+ T cells in the colon.
Shirai
Toshihiro
T
Department of Respiratory Medicine, Shizuoka General Hospital, Shizuoka. tmjkshi@general-hosp.pref.shizuoka.jp
Komiyama
Akira
A
Hayakawa
Hiroshi
H
Hashimoto
Dai
D
Suda
Takafumi
T
Chida
Kingo
K
D000328:Adult; D000368:Aged; D001249:Asthma / Q000150:complications*; D016022:Case-Control Studies; D004802:Eosinophilia / Q000150:complications* / Q000276:immunology* / Q000473:pathology; D004804:Eosinophils / Q000276:immunology / Q000473:pathology; D005260:Female; D005767:Gastrointestinal Diseases / Q000150:complications* / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008264:Macrophages / Q000276:immunology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology