title: Non-adherence to immunosuppressive medication in renal transplant recipients within the scope of the Integrative Model of Behavioral Prediction: a cross-sectional study.
abstract: BACKGROUND
  Non-adherence to immunosuppressive medication is strongly associated with poor outcomes. Identifying the factors influencing it is a first step in developing adherence interventions. This study's objective was to investigate the prevalence of self-reported and collaterally-reported non-adherence to immunosuppressives, and, based on the Integrative Model of Behavioral Prediction, to explore the association between non-adherence, intention to adhere, attitudes, norms and self-efficacy.
  
  
  METHODS
  This cross-sectional study included a convenience sample of 114 renal transplant recipients in follow-up care, one to five yr post-transplant. Non-adherence was measured by self-reports and collateral reports. Factors of the Integrative Model of Behavioral Prediction were assessed using a self-report questionnaire.
  
  
  RESULTS
  Self-reports showed non-adherence of 23.7%; collateral reports showed 3.8%; and a combination of the two showed 26.4%. Logistic regression analysis showed that the attitude "Not all immunosuppressive drugs are necessary to prevent rejection" was less frequent in patients with higher intentions to adhere, with an odds ratio (OR) of 0.05 (95% CI 0.01-0.50). The barrier of "Forgetfulness/Interruption of daily routine" was associated with non-adherence, with an OR of 3.74 (95% CI 1.55-9.03).
  
  
  CONCLUSIONS
  Forgetfulness is the most powerful barrier against adherence. Intention to adhere plays a minor role in non-adherence in renal transplant recipients.
authors: Institute of Nursing Science, University of Basel, Zurich, Switerland.
authors: Gabriela
authors: G
authors: Schmid-Mohler
authors: Martina Pechula
authors: MP
authors: Thut
authors: Rudolf Peter
authors: RP
authors: Wüthrich
authors: Kris
authors: K
authors: Denhaerynck
authors: Sabina
authors: S
authors: De Geest
mesh_terms: D003430:Cross-Sectional Studies; D015438:Health Behavior; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D033182:Intention; D016030:Kidney Transplantation / Q000276:immunology; D008568:Memory; D008960:Models, Psychological; D010349:Patient Compliance / Q000523:psychology* / Q000706:statistics & numerical data; D020377:Self Efficacy
chemical_list: D007166:Immunosuppressive Agents