Design, synthesis and analgesic properties of novel conformationally-restricted N-acylhydrazones (NAH).
A set of six azaheterocycles were designed as conformationally-constrained N-acylhydrazones and tested as analgesics.
Kümmerle
Arthur E
AE
Laboratório de Avaliação e Síntese de Substâncias Bioativas (LASSBio), Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, RJ, Brazil.
Vieira
Marina M
MM
Schmitt
Martine
M
Miranda
Ana L P
AL
Fraga
Carlos A M
CA
Bourguignon
Jean-Jacques
JJ
Barreiro
Eliezer J
EJ
D000700:Analgesics / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D015195:Drug Design; D006835:Hydrazones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051379:Mice; D008968:Molecular Conformation; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D000700:Analgesics; D006835:Hydrazones