title: From osteoarthritis treatments to future regenerative therapies for cartilage.
abstract: Osteoarthritis (OA) is associated with cartilage degeneration and an accompanying inflammatory syndrome of the synovium in addition to alteration of the subchondral bone. The molecular and cellular events involved in OA have only partially been elucidated. This review provides a global view of the physiopathology of OA, as well as non-pharmacological and pharmacological treatments for the disorder. An update on surgical treatments and their indications is given with an orientation towards the management of OA and cartilage repair by cell-based regenerative therapies. These promising biological technologies will, potentially, play a major role in the treatment of cartilage-associated diseases.
authors: INSERM (Institut National de la Santé et de la Recherche Médicale), U791, Centre for Osteoarticular and Dental Tissue Engineering, Group Physiopathology of Skeletal Tissues and Cartilage Engineering, University of Nantes, France.
authors: Johann
authors: J
authors: Clouet
authors: Claire
authors: C
authors: Vinatier
authors: Christophe
authors: C
authors: Merceron
authors: Marianne
authors: M
authors: Pot-vaucel
authors: Yves
authors: Y
authors: Maugars
authors: Pierre
authors: P
authors: Weiss
authors: Gaël
authors: G
authors: Grimandi
authors: Jérôme
authors: J
authors: Guicheux
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001174:Arthrodesis; D019643:Arthroplasty, Replacement; D002358:Cartilage, Articular / Q000187:drug effects* / Q000503:physiopathology / Q000601:surgery*; D017690:Cell Transplantation; D015316:Genetic Therapy; D006801:Humans; D019637:Orthopedic Procedures; D010003:Osteoarthritis / Q000235:genetics / Q000503:physiopathology / Q000628:therapy*; D010027:Osteotomy; D012038:Regeneration / Q000187:drug effects* / Q000235:genetics; D023822:Tissue Engineering / Q000379:methods; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents