Oxidant-controlled regioselectivity in the oxidative arylation of N-acetylindoles.
N-Acetylindoles can be oxidatively coupled with arenes such as benzene or pentafluorobenzene in dioxane. The use of Cu(OAc)(2) as the stoichiometric oxidant produces selective arylation at the 3-position of indole while AgOAc produces selective arylation at indole's 2-position.
Potavathri
Shathaverdhan
S
Department of Chemistry, University of Rhode Island, Kingston, Rhode Island 02881.
Dumas
Ashley S
AS
Dwight
Timothy A
TA
Naumiec
Gregory R
GR
Hammann
Jeffrey M
JM
Deboef
Brenton
B