title: Bifurcation and chaos in a model of cardiac early afterdepolarizations.
abstract: Excitable cells can exhibit complex patterns of oscillations, such as spiking and bursting. In cardiac cells, pathological voltage oscillations, called early afterdepolarizations (EADs), have been widely observed under disease conditions, yet their dynamical mechanisms remain unknown. Here, we show that EADs are caused by Hopf and homoclinic bifurcations. During period pacing, chaos always occurs at the transition from no EAD to EADs as the stimulation frequency decreases, providing a distinct explanation for the irregular EAD behavior frequently observed in experiments.
authors: Department of Medicine, Cardiology, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA.
authors: Diana X
authors: DX
authors: Tran
authors: Daisuke
authors: D
authors: Sato
authors: Arik
authors: A
authors: Yochelis
authors: James N
authors: JN
authors: Weiss
authors: Alan
authors: A
authors: Garfinkel
authors: Zhilin
authors: Z
authors: Qu
mesh_terms: D015220:Calcium Channels / Q000378:metabolism; D006321:Heart / Q000502:physiology*; D015640:Ion Channel Gating; D008564:Membrane Potentials; D008955:Models, Cardiovascular; D009206:Myocardium / Q000378:metabolism; D017711:Nonlinear Dynamics; D015221:Potassium Channels / Q000378:metabolism; D015222:Sodium Channels / Q000378:metabolism
chemical_list: D015220:Calcium Channels; D015221:Potassium Channels; D015222:Sodium Channels