Femtosecond-assisted lamellar keratoplasty in atypical Avellino corneal dystrophy of Indian origin.
OBJECTIVE
To report a case of Avellino corneal dystrophy (ACD) in a patient of Indian origin treated with femtosecond-assisted lamellar keratoplasty (FALK).


METHODS
A 6-year-old male patient presented with severe photophobia with decreased vision for 2 months. A clinical diagnosis of Avellino dystrophy was made after complete examination under anesthesia and FALK was performed.


RESULTS
The postoperative period was uneventful with good symptomatic improvement and graft clarity. Histopathological study with special staining, namely Masson trichrome and Congo red stain, of the patient's corneal button showed features of both granular and lattice lesions suggestive of ACD. Genetic analysis showed absence of R124H mutation in BIGH3 gene. No recurrence or exacerbation was noted at 19-month follow-up.


CONCLUSIONS
To our knowledge, this is the first case report of clinical, histopathological, microscopic features of ACD in young patient of Indian origin with absence of BIGH3 gene treated with FALK with IntraLase Femtosecond Laser for donor and recipient cuts.
Agarwal
Amar
A
Department of Ophthalmology, Eye Research Centre and Dr. Agarwal's Group of Eye Hospitals, Chennai, India. dragarwal@vsnl.com
Brubaker
Jacob W
JW
Mamalis
Nick
N
Kumar
Dhivya Ashok
DA
Jacob
Soosan
S
Chinnamuthu
Sujatha
S
Nair
Vidya
V
Prakash
Gaurav
G
Meduri
Alessandro
A
Agarwal
Athiya
A
D044466:Asian People; D002648:Child; D003315:Cornea / Q000473:pathology; D003317:Corneal Dystrophies, Hereditary / Q000150:complications / Q000208:ethnology / Q000473:pathology* / Q000601:surgery*; D016039:Corneal Transplantation / Q000379:methods*; D016326:Extracellular Matrix Proteins / Q000235:genetics; D006801:Humans; D007194:India; D053685:Laser Therapy / Q000379:methods*; D008297:Male; D009154:Mutation; D020795:Photophobia / Q000209:etiology; D012720:Severity of Illness Index; D016212:Transforming Growth Factor beta / Q000235:genetics; D014786:Vision Disorders / Q000209:etiology; D000099222:betaIG-H3 Protein
D016326:Extracellular Matrix Proteins; D016212:Transforming Growth Factor beta; D000099222:betaIG-H3 Protein