[Large hepatocellular carcinoma successfully treated with transarterial chemoembolization using cisplatin].
A 83-year-old man was admitted to our hospital with a large hepatic tumor located in lateral segment. Alpha-fetoprotein was 7ng/ml, and protein induced by vitamin K deficiency and antagonist-II (PIVKA-II) was 50792mAU/ml. The tumor was diagnosed as hepatocellular carcinoma (HCC) by angiographically assisted CT. No ascites was detected and major serological findings were T-Bil 0.7mg/dl, Alb 4.2g/dl, and PT 129%. Because of advanced age and a history of heart disease, he was treated with transarterial chemoembolization using cisplatin (Lip-TACE). The total dose was 128mg of cisplatin and 15ml of lipiodol. No adverse effects appeared. After the third session of Lip-TACE, the levels of PIVKA-II became negative and continued within the normal range for 26 months. We confirmed a decrease of HCC with lipiodol accumulation by abdominal CT, and the response rate was PR. He has been well for 3 years since the first Lip-TACE procedure.
Harada
Wakako
W
Department of Gastroenterology, Hiroshima Prefectural Hospital, Japan.
Kitamoto
Mikiya
M
Hayashi
Ryohei
R
Noda
Ikue
I
Hiramoto
Tomoki
T
Akagi
Morihisa
M
Watanabe
Chiyuki
C
Yamada
Hiroyasu
H
Sumioka
Masaaki
M
Imagawa
Masaru
M
Okimoto
Tomoaki
T
D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D006528:Carcinoma, Hepatocellular / Q000628:therapy*; D016461:Chemoembolization, Therapeutic / Q000379:methods*; D002945:Cisplatin / Q000008:administration & dosage*; D006801:Humans; D008113:Liver Neoplasms / Q000628:therapy*; D008297:Male
D000970:Antineoplastic Agents; D002945:Cisplatin