Proteomics: the tool to bridge the gap between the facts and fables of telomerase.
Genomic analysis has provided a huge cohort of data that has shed light on the regulation and structure of telomerase and will continue to influence its study profoundly. However, genomic and proteomic data need to be collated in order to bridge the gap between telomerase regulation and its crucial role in carcinogenesis. This review highlights significant advances in understanding the regulation of telomerase activity in the realm of genomics and proteomics focusing on the importance of telomerase as a future prognostic and diagnostic marker.
Thakkar
Dipti
D
School of Forensic and Investigative Sciences, University of Central Lancashire, UK. aashervington@uclan.ac.uk
Shervington
Amal
A
D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism / Q000502:physiology; D044127:Epigenesis, Genetic / Q000502:physiology; D015971:Gene Expression Regulation, Enzymologic; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis / Q000201:enzymology / Q000235:genetics; D011379:Prognosis; D011485:Protein Binding / Q000502:physiology; D040901:Proteomics / Q000379:methods*; D019098:Telomerase / Q000235:genetics / Q000378:metabolism / Q000502:physiology*
D014408:Biomarkers, Tumor; D019098:Telomerase