title: Swerilactones A and B, anti-HBV new lactones from a tradtional Chinese herb: Swertia mileensis as a treatment for viral hepatitis.
abstract: Swerilactones A (1) and B (2), two novel lactones with an unprecedented 6/6/6/6/6 pentacyclic ring system, were isolated from the traditional Chinese herb of Swertia mileensis with activity against the hepatitis virus. Their structures and relative stereochemistry were elucidated based on spectroscopic methods and further confirmed by X-ray single crystal diffraction analysis. In vitro antihepatitis B virus (HBV) assay on Hep G 2.2.15 cell line showed that compound 1 inhibited HBsAg and HBeAg secretion with IC(50) values of 3.66 and 3.58 mM, respectively.
authors: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PRC.
authors: Chang-An
authors: CA
authors: Geng
authors: Zhi-Yong
authors: ZY
authors: Jiang
authors: Yun-Bao
authors: YB
authors: Ma
authors: Jie
authors: J
authors: Luo
authors: Xue-Mei
authors: XM
authors: Zhang
authors: Hong-Ling
authors: HL
authors: Wang
authors: Yong
authors: Y
authors: Shen
authors: Ai-Xue
authors: AX
authors: Zuo
authors: Jun
authors: J
authors: Zhou
authors: Ji-Jun
authors: JJ
authors: Chen
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D006514:Hepatitis B Surface Antigens / Q000737:chemistry; D018936:Hepatitis C Antigens / Q000737:chemistry; D007783:Lactones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D029967:Swertia / Q000737:chemistry*; D014965:X-Rays
chemical_list: D000998:Antiviral Agents; D004365:Drugs, Chinese Herbal; D006514:Hepatitis B Surface Antigens; D018936:Hepatitis C Antigens; D007783:Lactones; C546816:swerilactone A; C546817:swerilactone B