title: [Effect of intravenous laser blood irradiation on endothelial dysfunction in patients with hypertensive disease].
abstract: The aim of this work was to study effect of intravenous laser blood irradiation (ILBI) on endothelial dysfunction in 120 patients (mean age 53.4 +/- 1.3 yr) with grade I-II hypertensive disease (HD) allocated to 2 groups. Traditional drug therapy given to patients of control group was supplemented by ILBI using a Mulat laser therapy device in the study group. Endothelial function was evaluated from the total plasma concentration of stable NOx metabolites, nitrates (NO3-), nitrites (NO2-), and Willebrand's factor. HD patients were found to have elevated activity of the Willebrand factor and show 3 types of response of the NO generating system: (1) decreased NO synthesis, (2) lack of its changes, and (3) increased NO synthesis. NO production in HD patients negatively correlated with systolic (r = -0.59) and diastolic (r = - 0.64) arterial pressure (AP) which suggests the relationship between decreased NO production and elevated AP. Inclusion of ILBl in the therapy of HD resulted in a significant decrease of Willebrand's factor activity and normalization of the NO level regardless of its initial value.
authors: N M
authors: NM
authors: Burduli
authors: O M
authors: OM
authors: Aleksandrova
mesh_terms: D000328:Adult; D000368:Aged; D001769:Blood / Q000528:radiation effects*; D001794:Blood Pressure / Q000502:physiology; D004730:Endothelium, Vascular / Q000378:metabolism / Q000503:physiopathology* / Q000528:radiation effects; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000503:physiopathology / Q000532:radiotherapy*; D028022:Low-Level Light Therapy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000096:biosynthesis / Q000097:blood*; D016896:Treatment Outcome; D014664:Vasodilation / Q000502:physiology* / Q000528:radiation effects; D014841:von Willebrand Factor / Q000096:biosynthesis*
chemical_list: D014841:von Willebrand Factor; D009569:Nitric Oxide