title: Molecular regulation of hepatic dendritic cell function and its relation to liver transplant outcome.
abstract: Studies on liver interstitial dendritic cells (DC) indicate that the maturation and function of these important antigen-presenting cells may be suppressed by continual exposure to microbial products from the gut, in particular, bacterial lipopolysaccharide. New evidence is emerging for a role of specific intracellular regulators of signal transduction and of cytokines in the hepatic microenvironment, which may contribute to a hyporesponsive state in liver DC. Analysis of signaling molecule expression within DC in liver transplant tissue is likely to uncover its relation to allograft outcome.
authors: Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
authors: Tina L
authors: TL
authors: Sumpter
authors: John G
authors: JG
authors: Lunz
authors: A Jake
authors: AJ
authors: Demetris
authors: Angus W
authors: AW
authors: Thomson
mesh_terms: D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology*; D004731:Endotoxins / Q000276:immunology; D006085:Graft Survival / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology; D016753:Interleukin-10 / Q000276:immunology; D018664:Interleukin-12 / Q000276:immunology; D008099:Liver / Q000276:immunology*; D016031:Liver Transplantation / Q000276:immunology*; D051379:Mice; D051201:Toll-Like Receptor 10 / Q000276:immunology; D051193:Toll-Like Receptors / Q000276:immunology; D014184:Transplantation, Homologous / Q000276:immunology; D016896:Treatment Outcome
chemical_list: D004731:Endotoxins; C475955:TLR10 protein, human; C539093:Tlr13 protein, mouse; D051201:Toll-Like Receptor 10; D051193:Toll-Like Receptors; D016753:Interleukin-10; D018664:Interleukin-12