CB1 activity in male reproduction: mammalian and nonmammalian animal models.
The importance of the endocannabinoid system (ECBS) and its involvement in several physiological processes is still increasing. Since the isolation of the main active compound of Cannabis sativa, Delta(9)-THC, several lines of research have evidenced the basic roles of this signaling system mainly considering its high conservation during evolution. In this chapter the attention is focussed on the involvement of the ECBS in the control of male reproductive aspects at both central and local levels which are both considered from a comparative point of view.
Pierantoni
Riccardo
R
Dipartimento di Medicina Sperimentale, Seconda Università di Napoli, Via Costantinopoli, Napoli, Italy.
Cobellis
Gilda
G
Meccariello
Rosaria
R
Cacciola
Giovanna
G
Chianese
Rosanna
R
Chioccarelli
Teresa
T
Fasano
Silvia
S
D000818:Animals; D001921:Brain / Q000502:physiology; D063385:Cannabinoid Receptor Modulators / Q000502:physiology*; D008297:Male; D023421:Models, Animal; D010902:Pituitary Gland / Q000502:physiology; D043884:Receptor, Cannabinoid, CB1 / Q000032:analysis / Q000502:physiology*; D012098:Reproduction / Q000502:physiology*; D012671:Seminiferous Tubules / Q000502:physiology; D013094:Spermatozoa / Q000737:chemistry / Q000502:physiology; D013737:Testis / Q000502:physiology
D063385:Cannabinoid Receptor Modulators; D043884:Receptor, Cannabinoid, CB1