title: Non-motor symptoms in atypical and secondary parkinsonism: the PRIAMO study.
abstract: The PRIAMO study is a cross-sectional longitudinal observational study aimed at describing epidemiology and evolution of non-motor symptoms (NMS) in patients with different forms of parkinsonism recruited in 55 Italian centres and evaluated over 24 months. In this paper, we are reporting prevalence and clinical characteristics of NMS in patients with atypical and secondary parkinsonism. Out of 1307 consecutive patients with a diagnosis of parkinsonism, 83 patients had vascular parkinsonism (VP), 34 had multiple system atrophy (MSA), 30 had progressive supranuclear palsy (PSP), 14 had dementia with Lewy bodies (DLB) and 11 had corticobasal degeneration (CBD). MSA and DLB had the highest number of NMS domains and symptoms, respectively. Gastrointestinal symptoms, pain, urinary problems and postural instability due to orthostatic hypotension were most frequent in MSA. Sleep disturbances were also common with a prevalence of approximately 70% in all diagnostic groups but CBD (36%). Psychiatric symptoms and attention and memory impairment were frequently observed in all diagnoses but were most prevalent among DLB patients, whereas the prevalence of skin and respiratory disorders was rather low in all forms, ranging between 10 and 30%. Atypical parkinsonism patients also reported a low QoL, with no significant differences among the different forms, whereas PD and VP patients had a better QoL.
authors: Dipartimento di Scienze Neurologiche, Sapienza Università di Roma, Rome, Italy. carlo.colosimo@uniroma1.it
authors: Carlo
authors: C
authors: Colosimo
authors: Letterio
authors: L
authors: Morgante
authors: Angelo
authors: A
authors: Antonini
authors: Paolo
authors: P
authors: Barone
authors: Tania P
authors: TP
authors: Avarello
authors: Edo
authors: E
authors: Bottacchi
authors: Antonino
authors: A
authors: Cannas
authors: Maria Gabriella
authors: MG
authors: Ceravolo
authors: Roberto
authors: R
authors: Ceravolo
authors: Giulio
authors: G
authors: Cicarelli
authors: Rosa M
authors: RM
authors: Gaglio
authors: Luisa
authors: L
authors: Giglia
authors: Francesco
authors: F
authors: Iemolo
authors: Michela
authors: M
authors: Manfredi
authors: Giuseppe
authors: G
authors: Meco
authors: Alessandra
authors: A
authors: Nicoletti
authors: Massimo
authors: M
authors: Pederzoli
authors: Alfredo
authors: A
authors: Petrone
authors: Antonio
authors: A
authors: Pisani
authors: Francesco E
authors: FE
authors: Pontieri
authors: Rocco
authors: R
authors: Quatrale
authors: Silvia
authors: S
authors: Ramat
authors: Rossana
authors: R
authors: Scala
authors: Giampiero
authors: G
authors: Volpe
authors: Salvatore
authors: S
authors: Zappulla
authors: Anna Rita
authors: AR
authors: Bentivoglio
authors: Fabrizio
authors: F
authors: Stocchi
authors: Giorgio
authors: G
authors: Trianni
authors: Paolo
authors: P
authors: Del Dotto
authors: Lucia
authors: L
authors: Simoni
authors: Roberto
authors: R
authors: Marconi
mesh_terms: D000368:Aged; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007558:Italy / Q000453:epidemiology; D020961:Lewy Body Disease / Q000453:epidemiology; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D019578:Multiple System Atrophy / Q000453:epidemiology; D019636:Neurodegenerative Diseases / Q000453:epidemiology; D010302:Parkinson Disease, Secondary / Q000453:epidemiology*; D020734:Parkinsonian Disorders / Q000453:epidemiology*; D015995:Prevalence; D013494:Supranuclear Palsy, Progressive / Q000453:epidemiology