title: Influence of dexamethasone on the expression levels of P-selectin protein in multiple organs of rats with severe acute pancreatitis.
abstract: OBJECTIVE
  To investigate the effect of dexamethasone on the expression levels of P-selectin protein in multiple organs of rats with severe acute pancreatitis (SAP).
  
  
  METHODS
  Rats were randomly divided into sham-operated, model control, and dexamethasone-treated groups. At 3, 6, and 12 h after operation, the expression levels of P-selectin protein in one-third of the rats in each group were observed.
  
  
  RESULTS
  In the treated group, the expression levels of P-selectin protein in the pancreas head (at 6 h), lung (at 12 h), liver (at 3 h), and spleen (at 6 and 12 h) were significantly lower than those in the model control group (P < 0.05). Additionally, the products of the staining intensity and positive rate of P-selectin protein in liver (at 3 h), lung (at 6 and 12 h), and spleen (at 12 h) in the treated group were significantly lower than those in the model control group (P < 0.05).
  
  
  CONCLUSIONS
  Dexamethasone can inhibit P-selectin protein expression in multiple organs of SAP rats.
authors: Department of General Surgery, Hangzhou First People's Hospital, Zhejiang, China. zxp99688@vip.163.com
authors: Zhang
authors: Z
authors: Xiping
authors: Fu
authors: F
authors: Jun
authors: Zhang
authors: Z
authors: Jie
authors: Yu
authors: Y
authors: Bingyan
authors: Ma
authors: M
authors: Jing
authors: Zhu
authors: Z
authors: Wei
authors: Ye
authors: Y
authors: Jing
authors: Jia
authors: J
authors: Penghui
authors: Yuan
authors: Y
authors: Wenqin
authors: Zhou
authors: Z
authors: Ninnin
authors: He
authors: H
authors: Jiao
mesh_terms: D000208:Acute Disease; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D003907:Dexamethasone / Q000627:therapeutic use*; D004195:Disease Models, Animal; D007668:Kidney / Q000378:metabolism / Q000473:pathology; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008168:Lung / Q000378:metabolism / Q000473:pathology; D008297:Male; D019007:P-Selectin / Q000378:metabolism*; D010179:Pancreas / Q000378:metabolism / Q000473:pathology; D010195:Pancreatitis / Q000188:drug therapy* / Q000378:metabolism* / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012720:Severity of Illness Index; D013154:Spleen / Q000378:metabolism / Q000473:pathology
chemical_list: D000893:Anti-Inflammatory Agents; D019007:P-Selectin; D003907:Dexamethasone