title: Effect of local cold-pack application on systemic anabolic and inflammatory response to sprint-interval training: a prospective comparative trial.
abstract: We evaluated the effect of cold ice-pack application following a brief sprint-interval training on the balance between anabolic mediators [growth hormone (GH), insulin-like growth factor-I (IGF-I), testosterone], catabolic markers (cortisol, IGFBP-1), and circulating pro [Interlukin-6 (IL-6) and IL-1beta]- and anti-inflammatory cytokines [IL-1 receptor antagonist (IL-1ra)]. Twelve males, elite junior handball players performed 4 x 250 m treadmill run, at 80% of each individual's maximal speed, followed by a rest period with and without local cold-pack application. Pre, immediately post, and 60-min post-exercise blood samples were drawn. Exercise was associated with a significant increase in IL-6, GH, IGFBP-3, and testosterone levels. Local cold-pack application was associated with significant decreases in IL-1beta, IL-1ra, IGF-I, and IGFBP-3 and a greater increase of IGFBP-1 during recovery. Local ice therapy immediately following sprint-interval training was associated with greater decreases in both pro- and anti-inflammatory cytokines and anabolic hormones supporting some clinical evidence for possible negative effects on athletic performance.
authors: Pediatric Department, Meir Medical Center, Child Health & Sport Center, Sackler School of Medicine, Tel-Aviv University, Kfar-Saba 44821, Israel. dnemet@gmail.com
authors: Dan
authors: D
authors: Nemet
authors: Yoav
authors: Y
authors: Meckel
authors: Sheli
authors: S
authors: Bar-Sela
authors: Frank
authors: F
authors: Zaldivar
authors: Dan M
authors: DM
authors: Cooper
authors: Alon
authors: A
authors: Eliakim
mesh_terms: D000328:Adult; D056352:Athletes; D001833:Body Temperature Regulation / Q000502:physiology; D003080:Cold Temperature; D016207:Cytokines / Q000097:blood; D019382:Human Growth Hormone / Q000097:blood; D006801:Humans; D007036:Hypothermia, Induced / Q000379:methods; D007249:Inflammation / Q000503:physiopathology*; D018836:Inflammation Mediators / Q000097:blood; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000097:blood; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D008297:Male; D008660:Metabolism / Q000502:physiology*; D005082:Physical Exertion / Q000502:physiology; D010809:Physical Fitness / Q000502:physiology; D012420:Running / Q000502:physiology*; D055815:Young Adult
chemical_list: D016207:Cytokines; D018836:Inflammation Mediators; D018970:Insulin-Like Growth Factor Binding Protein 1; D018972:Insulin-Like Growth Factor Binding Protein 3; D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I