title: Exhaled pentane as a possible marker for survival and lipid peroxidation during radiotherapy for lung cancer--a pilot study.
abstract: To examine lipid peroxidation during radiotherapy (RT), exhaled pentane samples were collected from 11 lung cancer patients before RT and 30 and 120 min after the start of RT on days 1, 4 and 5 and at 30 and 40 Grays, if possible. Exhaled pentane samples were collected once from 30 healthy controls. Serum thiobarbituric-acid-reactive substances (TBARS) and conjugated dienes (CD) were obtained from patients on each exhaled air collection day. Lung cancer patients had higher exhaled pentane levels than controls (1.73 ng/L vs 0.83 ng/L, p=0.017). Exhaled pentane levels tended to decrease during the first RT day (p=0.075) and levels of CD decreased during the first week of RT (p=0.014). Higher pre-treatment pentane levels predicted better survival (p=0.003). Elevated exhaled pentane levels before RT may be due to the lipid peroxidation burden associated with cancer. The decrease of lipid peroxidation markers during RT may be attributable to enhanced antioxidant defense mechanisms.
authors: Department of Oncology, University of Tampere, Tampere, Finland. macro1@sci.fi
authors: Marika
authors: M
authors: Crohns
authors: Seppo
authors: S
authors: Saarelainen
authors: Jukka
authors: J
authors: Laitinen
authors: Kimmo
authors: K
authors: Peltonen
authors: Hannu
authors: H
authors: Alho
authors: Pirkko
authors: P
authors: Kellokumpu-Lehtinen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood / Q000378:metabolism*; D001944:Breath Tests; D016022:Case-Control Studies; D006801:Humans; D015227:Lipid Peroxidation / Q000528:radiation effects*; D008175:Lung Neoplasms / Q000097:blood / Q000378:metabolism* / Q000532:radiotherapy*; D008875:Middle Aged; D010420:Pentanes / Q000378:metabolism*; D010865:Pilot Projects; D015996:Survival Rate; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D010420:Pentanes; D017392:Thiobarbituric Acid Reactive Substances