title: Activation of NF-kB pathway by virus infection requires Rb expression.
abstract: The retinoblastoma protein Rb is a tumor suppressor involved in cell cycle control, differentiation, and inhibition of oncogenic transformation. Besides these roles, additional functions in the control of immune response have been suggested. In the present study we investigated the consequences of loss of Rb in viral infection. Here we show that virus replication is increased by the absence of Rb, and that Rb is required for the activation of the NF-kB pathway in response to virus infection. These results reveal a novel role for tumor suppressor Rb in viral infection surveillance and further extend the concept of a link between tumor suppressors and antiviral activity.
authors: Centro Nacional de Biotecnología, CSIC, Campus Universidad Autónoma, Madrid, Spain.
authors: Maria A
authors: MA
authors: Garcia
authors: Pedro
authors: P
authors: Gallego
authors: Michela
authors: M
authors: Campagna
authors: José
authors: J
authors: González-Santamaría
authors: Gloria
authors: G
authors: Martínez
authors: Laura
authors: L
authors: Marcos-Villar
authors: Anxo
authors: A
authors: Vidal
authors: Mariano
authors: M
authors: Esteban
authors: Carmen
authors: C
authors: Rivas
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D051379:Mice; D018345:Mice, Knockout; D016328:NF-kappa B / Q000378:metabolism*; D016160:Retinoblastoma Protein / Q000378:metabolism*; D054243:Vesicular Stomatitis / Q000378:metabolism*
chemical_list: D016328:NF-kappa B; D016160:Retinoblastoma Protein