title: Visualization of phase retardation of deep posterior eye by polarization-sensitive swept-source optical coherence tomography with 1-microm probe.
abstract: Polarization-sensitive optical coherence tomography (PS-OCT) can measure cross-sectional and volumetric images of birefringence in fibrous tissues that provides additional contrast to the intensity images. In this study, we develop polarization-sensitive swept-source OCT (PS-SS-OCT) at 1 microm for deep penetration of the sclera and lamina cribrosa in the posterior part of human eyes. A calibration method for polarization mode dispersion of a circulator, which is employed to conserve the optical power of the interferometer and achieve system sensitivity sufficient for retinal imaging is demonstrated. The A-scan rate, the axial resolution, and the sensitivity of the PS-SS-OCT are 28,000 Hz, 11.0 microm, 94.2 dB, respectively. The posterior part of the eyes of a healthy male subject are measured in vivo. Phase-retardation images show birefringence of deep sclera and lamina cribrosa and enhance the contrast which is not visible in the intensity images. In addition, unlike conventional OCT, our PS-SS-OCT showed polarization-insensitive intensity images, in which an artifact created by the birefringence of sclera has been successfully eliminated.
authors: Computational Optics Group in the University of Tsukuba, Tsukuba, Ibaraki, Japan. yamanari@optlab2.bk.tsukuba.ac.jp
authors: Masahiro
authors: M
authors: Yamanari
authors: Yiheng
authors: Y
authors: Lim
authors: Shuichi
authors: S
authors: Makita
authors: Yoshiaki
authors: Y
authors: Yasuno
mesh_terms: D000328:Adult; D002138:Calibration; D002829:Choroid / Q000473:pathology; D004867:Equipment Design; D006801:Humans; D007368:Interferometry / Q000379:methods*; D008297:Male; D015233:Models, Statistical; D055095:Optics and Photonics; D012160:Retina / Q000473:pathology*; D012590:Sclera / Q000473:pathology; D012680:Sensitivity and Specificity; D041623:Tomography, Optical Coherence / Q000295:instrumentation* / Q000379:methods*