Kaposi sarcoma-associated herpesvirus (KSHV): molecular biology and oncogenesis.
Kaposi sarcoma-associated herpesvirus (KSHV) is a double-stranded DNA herpesvirus belonging to the gamma-herpesvirinae subfamily. KSHV has been associated with the development of three neoplastic diseases: Kaposi sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman disease (MCD). In this review, we discuss the three KSHV-associated malignancies, KSHV genome, latent and lytic aspects of the viral lifecycle, putative viral oncogenes, as well as therapeutic regimens used for the treatment of KS, PEL, and MCD.
Wen
Kwun Wah
KW
Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.
Damania
Blossom
B
D005871:Castleman Disease / Q000821:virology*; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D019288:Herpesvirus 8, Human / Q000502:physiology*; D006801:Humans; D054685:Lymphoma, Primary Effusion / Q000821:virology*; D009858:Oncogenic Viruses; D012514:Sarcoma, Kaposi / Q000821:virology*; D014412:Tumor Virus Infections / Q000821:virology; D017735:Virus Latency