Evaluation of free radicals scavenging and immunity-modulatory activities of Purslane polysaccharides.
In this study, antioxidant and immunity-modulatory activities of Purslane polysaccharide were estimated. The results revealed that in a dose-dependent manner, Purslane polysaccharides could significantly scavenge superoxide anion, 1,1-diphenyl-2-picrylhydrazyl (DPPH(-)), nitric oxide and hydroxyl radicals. Furthermore, the Purslane polysaccharides could still effectively inhibit the red blood cell (RBC) haemolysis, and increase spleen, thymocyte T and B lymphocyte proliferation, it could be concluded that Purslane polysaccharides could be of considerable preventive and therapeutic significance to some free radical associated health problems such as ovarian cancer, by scavenging accumulating free radicals and enhancing immunity functions.
YouGuo
Chen
C
Department of Obstetrics and Gynecology, First Affiliated Hospital of Soochow University, Suzhou 215006, China. chenyg.doctor@yahoo.com.cn
ZongJi
Shen
S
XiaoPing
Chen
C
D000818:Animals; D000975:Antioxidants / Q000737:chemistry; D001713:Biphenyl Compounds / Q000737:chemistry; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000166:cytology; D005609:Free Radicals; D006861:Hydrogen Peroxide / Q000494:pharmacology; D017665:Hydroxyl Radical; D007107:Immune System / Q000187:drug effects; D010851:Picrates / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology; D011134:Polysaccharides / Q000737:chemistry*; D031822:Portulaca / Q000378:metabolism*; D051381:Rats; D013950:Thymus Gland / Q000166:cytology
D000975:Antioxidants; D001713:Biphenyl Compounds; D005609:Free Radicals; D010851:Picrates; D010936:Plant Extracts; D011134:Polysaccharides; D017665:Hydroxyl Radical; D006861:Hydrogen Peroxide; C004931:1,1-diphenyl-2-picrylhydrazyl