Oxidation of amines by flavoproteins.
Many flavoproteins catalyze the oxidation of primary and secondary amines, with the transfer of a hydride equivalent from a carbon-nitrogen bond to the flavin cofactor. Most of these amine oxidases can be classified into two structural families, the D-amino acid oxidase/sarcosine oxidase family and the monoamine oxidase family. This review discusses the present understanding of the mechanisms of amine and amino acid oxidation by flavoproteins, focusing on these two structural families.
Fitzpatrick
Paul F
PF
Department of Biochemistry, University of Texas Health Science Center, San Antonio, TX 78229, USA. fitzpatrick@biochem.uthscsa.edu
D000588:Amines / Q000378:metabolism*; D000818:Animals; D005420:Flavoproteins / Q000737:chemistry / Q000378:metabolism*; D008958:Models, Molecular; D008995:Monoamine Oxidase / Q000737:chemistry / Q000378:metabolism; D010084:Oxidation-Reduction; D011487:Protein Conformation
D000588:Amines; D005420:Flavoproteins; D008995:Monoamine Oxidase