title: High ratio of myeloid dendritic cells to plasmacytoid dendritic cells in blood of patients with acute coronary syndrome.
abstract: BACKGROUND
  Dendritic cells (DCs) stimulate T-cells to participate in the inflammatory processes that promote the destruction of vulnerable plaques. The relationship between circulating levels of myeloid DCs (mDCs) and plasmacytoid DCs (pDCs) in patients with acute coronary syndrome (ACS) was evaluated.
  
  
  RESULTS
  Blood samples were obtained from 39 patients with ACS, 41 patients with stable angina pectoris (SAP) and 43 controls. The proportion of mDCs tended to be lower in the ACS group than in the SAP group and controls. Interleukin-12 levels associated with mDCs were significantly higher in the ACS group than in control group. The proportion of pDCs was significantly lower in the ACS groups than in the other two groups. Interferon-alpha levels secreted by pDCs, however, were not significantly different among the 3 groups. The ratio of mDCs to pDCs >or=4 is an important value for distinguishing ACS from SAP patients and control patients through receiver operating characteristic analysis (sensitivity; 85.0%, specificity; 83.4%).
  
  
  CONCLUSIONS
  The ratio of mDCs to pDCs may be a useful marker for detecting ACS and the existence of vulnerable plaques.
authors: Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
authors: Takashi
authors: T
authors: Fukunaga
authors: Hirofumi
authors: H
authors: Soejima
authors: Atsushi
authors: A
authors: Irie
authors: Ryuichiro
authors: R
authors: Fukushima
authors: Yoko
authors: Y
authors: Oe
authors: Hiroaki
authors: H
authors: Kawano
authors: Hitoshi
authors: H
authors: Sumida
authors: Koichi
authors: K
authors: Kaikita
authors: Seigo
authors: S
authors: Sugiyama
authors: Yasuharu
authors: Y
authors: Nishimura
authors: Hisao
authors: H
authors: Ogawa
mesh_terms: D054058:Acute Coronary Syndrome / Q000175:diagnosis / Q000276:immunology*; D000368:Aged; D000369:Aged, 80 and over; D000787:Angina Pectoris / Q000175:diagnosis / Q000276:immunology*; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D002452:Cell Count; D002469:Cell Separation; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology*; D003937:Diagnosis, Differential; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D016898:Interferon-alpha / Q000097:blood; D018664:Interleukin-12 / Q000097:blood; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D022423:Myeloid Cells / Q000276:immunology*; D016017:Odds Ratio; D011237:Predictive Value of Tests; D012372:ROC Curve; D018570:Risk Assessment; D012421:Rupture
chemical_list: D015415:Biomarkers; D018836:Inflammation Mediators; D016898:Interferon-alpha; D018664:Interleukin-12; D002097:C-Reactive Protein