Disruption of transcriptionally active Stat3 dimers with non-phosphorylated, salicylic acid-based small molecules: potent in vitro and tumor cell activities.
Fletcher
Steven
S
Department of Chemistry, University of Toronto, Mississauga, Mississauga, ON L5L 1C6 (Canada).
Singh
Jagdeep
J
Zhang
Xiaolei
X
Yue
Peibin
P
Page
Brent D G
BD
Sharmeen
Sumaiya
S
Shahani
Vijay M
VM
Zhao
Wei
W
Schimmer
Aaron D
AD
Turkson
James
J
Gunning
Patrick T
PT
D000636:Aminosalicylic Acids / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001557:Benzenesulfonates / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects; D019281:Dimerization; D006801:Humans; D008958:Models, Molecular; D009369:Neoplasms / Q000737:chemistry / Q000378:metabolism* / Q000473:pathology*; D050796:STAT3 Transcription Factor / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism*; D020156:Salicylic Acid / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D015398:Signal Transduction; D054852:Small Molecule Libraries
D000636:Aminosalicylic Acids; D001557:Benzenesulfonates; C520337:NSC 74859; D050796:STAT3 Transcription Factor; D054852:Small Molecule Libraries; D020156:Salicylic Acid