An oral controlled release system for ambroxol hydrochloride containing a wax and a water insoluble polymer.
This study was carried out to develop and optimize oral sustained-release formulations for Ambroxol hydrochloride matrix pellets using a combination of wax and water-insoluble polymer, glyceryl behenate (Compritol 888 ATO) and Ethylcellulose (EC(7 FP)). It involved three factors: the content of Compritol 888 ATO (X(1)), EC(7 FP) (X(2)), and the matrix formation methods (X(3)), as independent variables. The drug release percentages at 1, 2 and 4 h were the target responses and were restricted to 15-45% (Y(1)), 45-80% (Y(2)) and 80-100% (Y(3)), respectively. The final blend formulation prepared by extrusion spheronization, was achieved with 27.00% (w/w) Ambroxol hydrochloride, 48.70% (w/w) Compritol 888 ATO, and 24.30% (w/w) EC(7 Fp) with 40 degrees C for 12 h. Comparing the single matrix materials consisting of just the wax or water-insoluble in the complex matrix system containing wax and water-insoluble polymer, the release of the drug can be far more retarded, when the formulations have undergone the process of heat treatment. Furthermore, the combination of the two polymers, with flexible matrix formation methods, will offer a very promising way of producing matrix pellets instead of coated controlled-release pellets to meet various demands of drug release.
Chi
Na
N
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
Guo
Ju Hong
JH
Zhang
Yu
Y
Zhang
Wei
W
Tang
Xing
X
D000284:Administration, Oral; D000551:Ambroxol / Q000008:administration & dosage* / Q000032:analysis / Q000737:chemistry*; D002482:Cellulose / Q000031:analogs & derivatives; D003692:Delayed-Action Preparations; D004339:Drug Compounding / Q000379:methods*; D016503:Drug Delivery Systems; D015195:Drug Design; D004355:Drug Stability; D005079:Excipients; D005100:Expectorants / Q000008:administration & dosage / Q000032:analysis / Q000737:chemistry; D005227:Fatty Acids; D006358:Hot Temperature; D010316:Particle Size; D011108:Polymers; D012995:Solubility; D013696:Temperature; D014867:Water / Q000737:chemistry; D014885:Waxes
D003692:Delayed-Action Preparations; D005079:Excipients; D005100:Expectorants; D005227:Fatty Acids; D011108:Polymers; D014885:Waxes; D014867:Water; D000551:Ambroxol; C013517:ethyl cellulose; D002482:Cellulose