4,4-Disubstituted cyclohexylamine based CCR5 chemokine receptor antagonists as anti-HIV-1 agents.
A series of 4,4-disubstituted cyclohexylamine based CCR5 antagonists has been designed and synthesized. Their antiviral structure-activity relationship has been extensively explored.
Duan
Maosheng
M
Infectious Diseases Center for Excellence in Drug Discovery, GlaxoSmithKline, Five Moore Drive, Research Triangle Park, NC 27709, USA. maosheng.a.duan@gsk.com
Aquino
Christopher
C
Dorsey
George F
GF
Ferris
Robert
R
Kazmierski
Wieslaw M
WM
D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D065100:CCR5 Receptor Antagonists; D045744:Cell Line, Tumor; D003514:Cyclohexylamines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015658:HIV Infections / Q000188:drug therapy; D006801:Humans; D019713:Receptors, CCR5 / Q000378:metabolism; D013329:Structure-Activity Relationship
D019380:Anti-HIV Agents; D065100:CCR5 Receptor Antagonists; D003514:Cyclohexylamines; D019713:Receptors, CCR5