[Effect of diet on the pharmacokinetics of tebipenem pivoxil fine granules in healthy male volunteers].
Tebipenem pivoxil (TBPM-PI), a novel oral carbapenem antibiotic, is a prodrug of tebipenem (TBPM). We assessed the pharmacokinetics of TBPM-PI fine granules at 250 mg as potency in healthy male volunteers in fasting and non-fasting states. Cmax of TBPM in the non-fasting state was lowered to approximately 60% of that in the fasting state, however AUC(0-infinity) and urinary excretion of TBPM in the non-fasting state were almost equivalent to those in the fasting state when TBPM-PI fine granules were administered. In conclusion, the absorption rate of TBPM-PI was reduced in the non-fasting state after the administration of TBPM-PI fine granules, but intake of food had little influence on the absorption amount of TBPM. Thus the effect of diets on the pharmacokinetics of TBPM-PI would raise no problem in clinical use of TBPM-PI.
Nakashima
Mitsuyoshi
M
Hamamatsu Institute of Clinical Pharmacology & Therapeutics.
Morita
Jun
J
Takata
Toshihiko
T
Aizawa
Kazumasa
K
D000328:Adult; D015780:Carbapenems / Q000493:pharmacokinetics*; D004435:Eating / Q000502:physiology*; D005215:Fasting / Q000502:physiology*; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D055815:Young Adult
D015780:Carbapenems; C500135:tebipenem