[Diurnal dynamics of arterial pressure in patients with chronic glomerulonephritis and preserved renal function].
Monitoring arterial pressure (AP) was used to evaluate its daily dynamics in 136 patients with the hypertensive form of chronic glomerulonephritis (CgN) and preserved renal function and in 49 with essential arterial hypertension (EAH). Diagnosis of CGN was verified by the results of clinical, laboratory, and instrumental studies as well as morphological examination of nephrobiopsies. Diurnal AP dynamics was evaluated from the analysis of mean systolic, diastolic, and pulse pressure, their variability, loading time, and daily AP rhythm. It was shown that daily AP dynamics in patients with hypertensive CGN is characterized by high "pressure load" both in daytime and at night. Their daily AP rhythm was much more disturbed than in EAH patients. The normal fall of night AP in these groups occurred in 20 and 40% of the cases respectively and its inadequate decrease in 53 and 39%. Night-time hypertension was documented in 27 vs 9% of the cases. Disturbances of daily AP rhythm in patients with hypertensive CGN were associated with lower pulse pressure than in EAH patients, greater variability of diastolic AP at night, and smaller increase of systolic AP in the morning.
Borovkova
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D000328:Adult; D001706:Biopsy; D001794:Blood Pressure / Q000502:physiology*; D002908:Chronic Disease; D002940:Circadian Rhythm / Q000502:physiology*; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate / Q000502:physiology*; D005921:Glomerulonephritis / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D008297:Male; D009399:Nephrons / Q000473:pathology; D011379:Prognosis; D012720:Severity of Illness Index