title: Six percent hydroxyethyl starch 130/0.4 impacts differently on blood glucose than 4% gelatine in a swine model of mixed acidaemia.
abstract: BACKGROUND
  Tris-hydroxymethyl aminomethane can be used as a buffer in case of restricted ventilation, but hypoglycaemia is one adverse effect. The influence of a starch-based colloid [6% hydroxyethyl starch 130 kDa/0.4 (HES130)] vs. a gelatine-based colloid (4% polysuccinated gelatine) on blood glucose was investigated in a swine model of mixed acidaemia.
  
  
  METHODS
  Continuous colloid infusion was done in anaesthetized pigs with exogenously induced mixed acidaemia, which was maintained for 3 h. Pigs (approximately 40 kg, n = 6 in each group) were randomized to HES130 or 4% gelatine infusion (4 ml kg h(-1)). Infusion of an acid solution and low tidal volume ventilation induced mixed acidaemia. Treatment of mixed acidaemia with tris-hydroxymethyl aminomethane buffer, which is known to induce hypoglycaemia, prolonged anaesthesia, and volume support challenged the control of blood glucose. Hypoglycaemia was treated by individually dosed infusion of 5% glucose in sterile water.
  
  
  RESULTS
  Bolus infusion of HES130 led to a moderate peak in blood glucose in four pigs. Four pigs in the 4% gelatine group and three in the HES130 group needed glucose infusion to prevent a drop in blood glucose levels below the set threshold (4 mmol l(-1)). The total amount of the glucose infusion was significantly lower in the HES130 group compared with the 4% gelatine group (100 vs. 295 ml per pig, median, P < 0.05). Generally, the HES130 pigs required glucose at later time points during anaesthesia. The first HES130 pig needed 5% glucose 2 h later than the first 4% gelatine pig to prevent a drop of blood glucose below 4 mmol l(-1).
  
  
  CONCLUSIONS
  Volume support impacted specifically on blood glucose in this porcine model. Thus, an additional control of blood glucose seems recommendable whenever a change in the volume support occurs.
authors: Department of Anaesthesiology and Surgical Intensive Care Medicine, Campus Virchow and Campus Mitte, Germany.
authors: Martin
authors: M
authors: Russ
authors: Vera
authors: V
authors: Koch
authors: Tobias
authors: T
authors: Keckel
authors: Willehad
authors: W
authors: Boemke
authors: Bernhard
authors: B
authors: Hiebl
authors: Juliane K
authors: JK
authors: Unger
mesh_terms: D000138:Acidosis / Q000188:drug therapy / Q000378:metabolism*; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects*; D002021:Buffers; D002985:Clinical Protocols; D004195:Disease Models, Animal; D005780:Gelatin / Q000008:administration & dosage / Q000494:pharmacology; D005947:Glucose / Q000008:administration & dosage; D006895:Hydroxyethyl Starch Derivatives / Q000008:administration & dosage / Q000494:pharmacology*; D007003:Hypoglycemia / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D011897:Random Allocation; D013552:Swine; D014325:Tromethamine / Q000008:administration & dosage
chemical_list: D001786:Blood Glucose; D002021:Buffers; D006895:Hydroxyethyl Starch Derivatives; D014325:Tromethamine; D005780:Gelatin; D005947:Glucose