Tessaric acid derivatives induce G2/M cell cycle arrest in human solid tumor cell lines.
A series of analogs were synthesized in a straightforward manner from naturally available sesquiterpenes ilicic acid and tessaric acid. The in vitro antiproliferative activities were examined in the human solid tumor cell lines A2780, HBL-100, HeLa, SW1573, T-47D and WiDr. The most potent analog induced considerably growth inhibition in the range 1.9-4.5 microM. Cell cycle studies for tessaric acid derivatives indicated a prominent arrest of the cell cycle at the G(2)/M phase. Damage to the cells was permanent as determine by the so called 24+24 drug schedule.
León
Leticia G
LG
Instituto Universitario de Bio-Orgánica Antonio González, Universidad de La Laguna, C/Astrofísico Francisco Sánchez 2, 38206 La Laguna, Spain.
Donadel
Osvaldo J
OJ
Tonn
Carlos E
CE
Padrón
José M
JM
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D002455:Cell Division; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D016195:G2 Phase; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy; D021281:Quantitative Structure-Activity Relationship; D012717:Sesquiterpenes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
D000970:Antineoplastic Agents; D012717:Sesquiterpenes