Effects of Psilocybe argentipes on marble-burying behavior in mice.
Psilocybe argentipes is a hallucinogenic mushroom. The present study examined the effects of P. argentipes on marble-burying behavior, which is considered an animal model of obsessive-compulsive disorder. P. argentipes significantly inhibited marble-burying behavior without affecting locomotor activity as compared with the same dose of authentic psilocybin. These findings suggest that P. argentipes would be efficient in clinical obsessive-compulsive disorder therapy.
Matsushima
Yoshihiro
Y
Department of Health and Nutrition, Takasaki University of Health and Welfare, Gunma, Japan.
Shirota
Osamu
O
Kikura-Hanajiri
Ruri
R
Goda
Yukihiro
Y
Eguchi
Fumio
F
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects*; D002119:Calcium Carbonate; D016666:Fluvoxamine / Q000494:pharmacology; D006213:Hallucinogens / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009043:Motor Activity / Q000187:drug effects; D055391:Psilocybe; D014364:Tryptophan / Q000031:analogs & derivatives / Q000737:chemistry / Q000378:metabolism
D014150:Antipsychotic Agents; D006213:Hallucinogens; D014364:Tryptophan; D002119:Calcium Carbonate; D016666:Fluvoxamine