title: HLA-DRB1 and -DQB1 loci in three west African ethnic groups: genetic relationship with sub-Saharan African and European populations.
abstract: The Fulani of west Africa have been shown to be less susceptible to malaria and to mount a stronger immune response to malaria than sympatric ethnic groups. The analysis of HLA diversity is useful for the assessment of the genetic distance between the Fulani and sympatric populations, which represents the necessary theoretical background for the investigation of genetic determinants of susceptibility to malaria. We assessed the polymorphism of HLA-DRB1 and -DQB1 loci and analyzed the distribution of alleles/haplotypes in Fulani, Mossi, and Rimaibé from Burkina Faso. We then investigated the genetic relationship of these three ethnic groups with other sub-Saharan African populations as well as with Europeans. We confirmed that the Fulani from Burkina Faso are genetically distinct from sympatric Mossi and Rimaibé. Furthermore the Fulani from Burkina Faso are close to those from The Gambia and, intriguingly, share the distribution of specific alleles with east African populations (Amhara and Oromo). It is noteworthy that the HLA-DRB1*04 and -DQB1*02 alleles, which are implicated in the development of several autoimmune diseases, are present at high frequency in the Fulani, suggesting their potential involvement in the enhanced immune reactivity observed in this population.
authors: Department of Experimental Medicine, Sapienza University of Rome, Italy.
authors: Patrizia
authors: P
authors: Lulli
authors: Valentina D
authors: VD
authors: Mangano
authors: Annamaria
authors: A
authors: Onori
authors: Chiara
authors: C
authors: Batini
authors: Gaia
authors: G
authors: Luoni
authors: Bienvenu S
authors: BS
authors: Sirima
authors: Issa
authors: I
authors: Nebie
authors: Luciana
authors: L
authors: Chessa
authors: Vincenzo
authors: V
authors: Petrarca
authors: David
authors: D
authors: Modiano
mesh_terms: D000293:Adolescent; D000328:Adult; D017954:Africa South of the Sahara; D000354:Africa, Western; D000368:Aged; D002648:Child; D005060:Europe; D056426:Genetic Loci; D005828:Genetics, Population; D006683:HLA-DQ Antigens / Q000235:genetics* / Q000276:immunology; D059866:HLA-DQ beta-Chains; D006684:HLA-DR Antigens / Q000235:genetics* / Q000276:immunology; D059811:HLA-DRB1 Chains; D006801:Humans; D008562:Membrane Glycoproteins / Q000235:genetics* / Q000276:immunology; D008875:Middle Aged; D055815:Young Adult
chemical_list: D006683:HLA-DQ Antigens; D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; D008562:Membrane Glycoproteins