Analysis of single nucleotide polymorphisms in the FAS and CTLA-4 genes of peripheral T-cell lymphomas.
Angioimmunoblastic T-cell lymphoma (AILT) represents a subset of T-cell lymphomas but resembles an autoimmune disease in many of its clinical aspects. Despite the phenotype of effector T-cells and high expression of FAS and CTLA-4 receptor molecules, tumor cells fail to undergo apoptosis. We investigated single nucleotide polymorphisms (SNPs) of the FAS and CTLA-4 genes in 94 peripheral T-cell lymphomas. Although allelic frequencies of some FAS SNPs were enriched in AILT cases, none of these occurred at a different frequency compared to healthy individuals. Therefore, SNPs in these genes are not associated with the apoptotic defect and autoimmune phenomena in AILT.
Bonzheim
Irina
I
Institute of Pathology, University of Würzburg, Josef Schneider Strasse 2, 97080, Würzburg, Germany, irinabonzheim@gmx.de.
Geissinger
Eva
E
Chuang
Wen-Yu
WY
Roth
Sabine
S
Ströbel
Philipp
P
Marx
Alexander
A
Reimer
Peter
P
Wilhelm
Martin
M
Puppe
Bernhard
B
Rosenwald
Andreas
A
Müller-Hermelink
Hans Konrad
HK
Rüdiger
Thomas
T