title: Ricinus communis biocompatibility histological study in the nose of Cebus apella monkeys.
abstract: Bone tissue lesions can be caused by congenital and acquired factors, and result in nasal deformities with cosmetic and functional repercussion. Surgical treatment in these cases frequently requires complex reconstructions and the use of biomaterials. The polyurethane derived from castor beans (Ricinus communis) has a favorable formulation in terms of ease of processing, flexibility, no emission of toxic vapors and low cost. Nonetheless, despite favorable results, studies about the use of castor beam polymer (Ricinus communis) assessing tissue reaction on the nasal dorsum are still missing in the literature.
  
  
  OBJECTIVE
  the goal of the present investigation is to histologically assess the Ricinus communis polymer implant biocompatibility with the nasal dorsum.
  
  
  METHODS
  experimental.
  
  
  METHODS
  we used four Cebus appela monkeys, in which we created a nasal dorsal defect in all the animals and there we placed the aforementioned implant. The animals were sacrificed 270 days after surgery and the samples were submitted to histological study.
  
  
  RESULTS
  in the histology analysis we did not observe the presence of foreign body granulomas or phagocytic cells. We also observed a progressive bone formation and maturation.
  
  
  CONCLUSIONS
  macroscopic and microscopic results showed that the castor oil polymer implant was biocompatible.
authors: Federal University of São Paulo. pcjdias@ig.com.br
authors: Paulo Cesar de Jesus
authors: PC
authors: Dias
authors: Lidio
authors: L
authors: Granato
authors: Lizeti de Toledo de Oliveira
authors: Lde T
authors: Ramalho
authors: José Américo de
authors: JA
authors: Oliveira
authors: Hermes
authors: H
authors: Pretel
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use*; D018786:Bone Substitutes / Q000627:therapeutic use*; D002367:Ricinus communis / Q000737:chemistry*; D002368:Castor Oil / Q000627:therapeutic use*; D002428:Cebus; D008422:Materials Testing / Q000379:methods; D009295:Nasal Bone / Q000601:surgery*; D011140:Polyurethanes; D013997:Time Factors
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; D011140:Polyurethanes; D002368:Castor Oil