title: [Toxicological study of PFOS/PFOA to zebrafish (Danio rerio) embryos].
abstract: Acute toxicity of PFOS/PFOA to zebrafish (Danio rerio) and development effects to zebrafish embryo were examined using a zebrafish embryo test. PFOS/PFOA showed remarkably toxicity effects on zebrafish. The LC50 (48 h) values are 1 005 mg/L for PFOA, 107 mg/L for PFOS, while the LC50 (96 h) values are 499 mg/L for PFOA, 71 mg/L for PFOS. Moreover PFOS/PFOA inhibited embryo development, and caused embryo abnormality and death. After exposure to high concentration of PFOS (> 240 mg/L), cells in animal pole of embryos autolyzed to coagulate, which indicated PFOS caused cell membranes damage. The most sensitive endpoints for PFOS exposure is spinal column malformation, and the EC50 values is 9.14 mg/L. While for PFOA hatching (96 h) is the most sensitive, and the EC50 values is 328.0 mg/L. Both PFOS and PFOA retarded embryo development which indicates their development toxicity.
authors: College of Environmental Science and Engineering, State Key Laboratory of Pollution Control and Resources Reuse, Tongji University, Shanghai 200092, China. karen.yl@163.com
authors: Lu
authors: L
authors: Ye
authors: Ling-Ling
authors: LL
authors: Wu
authors: Yu-Xi
authors: YX
authors: Jiang
authors: Chao-Jie
authors: CJ
authors: Zhang
authors: Ling
authors: L
authors: Chen
mesh_terms: D017738:Alkanesulfonic Acids / Q000633:toxicity*; D000818:Animals; D002210:Caprylates / Q000633:toxicity*; D004625:Embryo, Nonmammalian / Q000187:drug effects; D047108:Embryonic Development / Q000187:drug effects*; D005466:Fluorocarbons / Q000633:toxicity*; D013723:Teratogens / Q000633:toxicity; D023382:Toxicity Tests, Acute / Q000379:methods; D014874:Water Pollutants, Chemical / Q000633:toxicity*; D015027:Zebrafish / Q000254:growth & development*
chemical_list: D017738:Alkanesulfonic Acids; D002210:Caprylates; D005466:Fluorocarbons; D013723:Teratogens; D014874:Water Pollutants, Chemical; C023036:perfluorooctanoic acid; C076994:perfluorooctane sulfonic acid