title: Fatigue in Japanese patients with Parkinson's disease: a study using Parkinson fatigue scale.
abstract: The objective of this multicenter cross-sectional study was to determine the prevalence of fatigue and factors contributing to it in a large sample of Japanese patients with Parkinson's disease (PD). We used the 16-item Parkinson Fatigue Scale (PFS-16), which was designed to assess fatigue exclusively associated with PD. We carried out this study using PFS-16, the Unified Parkinson's Disease Rating Scale, Zung's Self-Rating Depression Scale, Parkinson's Disease Sleep Scale (PDSS), and the PD quality of life (QOL) scale (PDQ-39) by interview using questionnaires and physical examination by neurologists in 361 nondemented PD patients. Fatigue (an average PFS score of 3.3 or greater) was revealed in 151 patients (41.8%). Multiple logistic regression analysis indicated that the significant independent variables related to the presence of fatigue were the scores of PDSS and PDQ-39. Depression score was not a significant contributing factor. Our study revealed that the prevalence of fatigue in Japanese PD patients is as high as that in Western countries, and that fatigue is a relatively independent symptom, although sleep disturbance may be associated with fatigue. Since fatigue is significantly related to QOL reduction, therapeutic interventions including treatment of sleep disturbance are important.
authors: Department of Neurology, Juntendo University Shizuoka Hospital, 1129 Nagaoka, Izunokuni, Shizuoka 410-2295, Japan. sgz02202@nifty.ne.jp
authors: Yasuyuki
authors: Y
authors: Okuma
authors: Satoshi
authors: S
authors: Kamei
authors: Akihiko
authors: A
authors: Morita
authors: Fumihito
authors: F
authors: Yoshii
authors: Toshimasa
authors: T
authors: Yamamoto
authors: Shiori
authors: S
authors: Hashimoto
authors: Hiroya
authors: H
authors: Utsumi
authors: Taku
authors: T
authors: Hatano
authors: Nobutaka
authors: N
authors: Hattori
authors: Miyuki
authors: M
authors: Matsumura
authors: Kazushi
authors: K
authors: Takahashi
authors: Shigeru
authors: S
authors: Nogawa
authors: Yuka
authors: Y
authors: Watanabe
authors: Tomoyuki
authors: T
authors: Miyamoto
authors: Masayuki
authors: M
authors: Miyamoto
authors: Koichi
authors: K
authors: Hirata
mesh_terms: D000368:Aged; D003430:Cross-Sectional Studies; D004185:Disability Evaluation; D018450:Disease Progression; D005221:Fatigue / Q000175:diagnosis* / Q000209:etiology*; D005260:Female; D006801:Humans; D007564:Japan; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications*; D017286:Polysomnography; D011569:Psychiatric Status Rating Scales; D018709:Statistics, Nonparametric; D011795:Surveys and Questionnaires