A dutch family with Hb Debrousse: severe anemia after parvovirus B19 infection.
Hb Debrousse [beta96(FG3)Leu-->Pro] is an unstable hemoglobin (Hb) variant with high oxygen affinity. We describe a case of chronic compensated hemolysis in a 39-year-old woman in whom the variant was found. Soon after the diagnosis was made, she and her son were admitted to the hospital with severe anemia due to Parvovirus B19 infection. The son also appeared to have the Hb Debrousse variant. Parvovirus B19 infection is a life-threatening disease in patients with (compensated) hemolysis.
van Balen
Peter
P
Department of Internal Medicine, Meander Medical Centre, Amersfoort, The Netherlands. pvanbalen@ziggo.nl
van Wijnen
Merel
M
Hogeman
Paul H G
PH
Wittebol
Shulamiet
S
D000328:Adult; D000743:Anemia, Hemolytic / Q000097:blood / Q000209:etiology / Q000235:genetics*; D005192:Family Health; D005260:Female; D006455:Hemoglobins, Abnormal / Q000235:genetics*; D006801:Humans; D009154:Mutation; D009426:Netherlands; D010322:Parvoviridae Infections / Q000150:complications* / Q000821:virology; D016732:Parvovirus B19, Human; D055544:beta-Globins / Q000235:genetics
D006455:Hemoglobins, Abnormal; D055544:beta-Globins; C098868:hemoglobin Debrousse