[Monocyte subpopulations in inflammation processes: principles and perspectives].
Monocytes are circulating precursors of macrophages and dendritic cells. They play critical roles in the inflammatory response and are associated with manifold inflammatory disorders. The discovery of human and murine monocyte subpopulations has revealed new insights into the migration, differentiation and functional role of these cells in the pathogenesis of inflammation. These findings are expected to identify novel targets for future therapeutic strategies.
Tacke
Frank
F
Medizinische Klinik III, Universitätsklinikum Aachen, Aachen. frank.tacke@gmx.net
D000818:Animals; D003713:Dendritic Cells / Q000473:pathology / Q000502:physiology; D004195:Disease Models, Animal; D006801:Humans; D007249:Inflammation / Q000473:pathology*; D008264:Macrophages / Q000473:pathology / Q000502:physiology; D051379:Mice; D009000:Monocytes / Q000145:classification* / Q000473:pathology* / Q000502:physiology