Emerging role of PPAR ligands in the management of diabetic nephropathy.
Diabetic nephropathy is a leading cause of morbidity and mortality in hyperglycemic patients. Angiotensin converting enzyme inhibitors and angiotensin-II AT(1) receptor blockers are currently employed to treat patients with diabetic nephropathy; but these agents are considered to be inadequate to control the symptoms of diabetic nephropathy. Recent studies suggest that PPAR ligands are promising agents to prevent the progression of diabetic nephropathy. In the present review, we discussed the novel role of PPARalpha and PPARgamma agonists in the management of diabetic nephropathy.
Balakumar
Pitchai
P
Cardiovascular Pharmacology Division, ISF College of Pharmacy, Moga 142001, Punjab, India. pbala2006@gmail.com
Arora
Mandeep Kumar
MK
Singh
Manjeet
M
D000818:Animals; D003928:Diabetic Nephropathies / Q000188:drug therapy*; D006801:Humans; D008024:Ligands; D047492:Peroxisome Proliferator-Activated Receptors / Q000819:agonists* / Q000502:physiology; D020033:Protein Isoforms
D008024:Ligands; D047492:Peroxisome Proliferator-Activated Receptors; D020033:Protein Isoforms