Clinical impact of aneuploidy on gastric cancer patients.
Gastric cancer is a leading cause of death worldwide. Nowadays, complete surgical resection and TNM at diagnosis are the main prognostic factors. In spite of this, many patients will have a recurrence after surgery and die within a few months or years. That means that we need more accurate prognostic factors to design specific approaches for individual patients. Chromosome instability is a feature of gastric cancer commonly associated to chromosomal aberrations that leads to major modifications of DNA content globally termed as aneuploidy. In this regard, many authors' opinions diverge regarding the clinical impact of aneuploidy. This review will summarise data on the clinical impact of aneuploidy on clinical practice, the biological mechanisms that underlie chromosomal instability that induces aneuploidy and the relevance of specific chromosomal aneuploidy to cancer biology.
Sánchez-Pérez
Isabel
I
Translational Oncology Unit CSIC/UAM, Instituto de Investigaciones Biomédicas CSIC/UAM, Madrid, Spain. misanchez@iib.uam.es
García Alonso
Pilar
P
Belda Iniesta
Cristóbal
C
D000782:Aneuploidy; D000818:Animals; D018385:Centrosome / Q000378:metabolism; D006801:Humans; D008941:Spindle Apparatus; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology