[Research advances in the mechanism of phenytoin-induced gingival overgrowth].
Phenytoin is widely used as an antiepileptic drug in clinic, but a common and well-known adverse effect of its administration is gingival overgrowth which may influence the aesthetics and function of the oral cavity. The pathogenesis of phenytoin-induced gingival overgrowth is not very clear now. This review summarized the influences of phenytoin on gingival fibroblast,collagen homeostasis and some cytokines, etc.
Zhang
Yan-hui
YH
Department of Periodontology, School of Stomatology, Shangdong University, Jinan 250012, Shangdong Province, China. zhangyanhui1112@163.com
Sun
Qin-feng
QF
Yang
Pi-shan
PS
D000927:Anticonvulsants; D005347:Fibroblasts; D005881:Gingiva; D019214:Gingival Overgrowth; D006801:Humans; D010672:Phenytoin
D000927:Anticonvulsants; D010672:Phenytoin