title: Parietal gray matter volume loss is related to spatial processing deficits in long-term abstinent alcoholic men.
abstract: BACKGROUND
  We previously demonstrated relatively intact cognitive function (with the exception of suggestive evidence for persistent deficits in spatial information processing) in middle-aged long-term abstinent alcoholics (LTAA, abstinent for 6 months or more) compared to age and gender comparable nonalcoholic controls (NAC) (Fein et al., 2006).
  
  
  METHODS
  In the current study, we examine cortical gray matter volumes in the same samples to determine whether gray matter volumes in LTAA are consistent with the cognitive results--i.e., exhibiting gray matter volumes comparable to NAC in most brain regions, except for possible indications of persistent shrinkage in the parietal lobe subserving spatial information processing.
  
  
  RESULTS
  We found gray matter shrinkage in LTAA in the parietal lobe consistent with the spatial processing deficits in this same sample. More compelling, in LTAA, the magnitude of parietal gray matter shrinkage was negatively associated with spatial processing domain performance and positively associated with alcohol dose. Gray matter volume deficits were present in the occipital and other cortical tissue, but poorer visuospatial test performance correlated significantly with smaller volumes in the parietal cortex only.
  
  
  CONCLUSIONS
  Taken together, the cognitive and structural imaging data provide compelling evidence that chronic alcohol abuse results in shrinkage of the parietal cortex with associated deficits in spatial information processing.
authors: Neurobehavioral Research, Inc., Honolulu, Hawaii 96814, USA. george@nbresearch.com
authors: George
authors: G
authors: Fein
authors: Ryan
authors: R
authors: Shimotsu
authors: Russell
authors: R
authors: Chu
authors: Jerome
authors: J
authors: Barakos
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000473:pathology* / Q000523:psychology*; D003071:Cognition / Q000187:drug effects; D003072:Cognition Disorders / Q000139:chemically induced* / Q000523:psychology*; D005260:Female; D005625:Frontal Lobe / Q000473:pathology; D006257:Head / Q000033:anatomy & histology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010296:Parietal Lobe / Q000473:pathology*; D011569:Psychiatric Status Rating Scales; D011597:Psychomotor Performance / Q000187:drug effects; D013028:Space Perception / Q000187:drug effects*; D013695:Temperance