Ortho-functionalization of 2-phenoxypyrimidines via palladium-catalyzed C-H bond activation.
The palladium-catalyzed direct acetoxylation and arylation of 2-aryloxypyrimidine has been described. The aromatic C-H bonds may be functionalized in moderate to excellent yields providing a facile method for the synthesis of phenol derivatives, which show antimycobacterial and herbicidal activities.
Gu
Shaojin
S
Department of Chemistry, Zhejiang University, Xixi Campus, Hangzhou 310028, PR China.
Chen
Chao
C
Chen
Wanzhi
W