title: [Expressions and clinical significance of caveolin-1 gene and protein in tongue squamous cell carcinoma].
abstract: OBJECTIVE
  To investigate the changes and the significance of caveolin-1 gene and protein in tongue squamous cell carcinoma(TSCC).
  
  
  METHODS
  Immunohistochemical staining and in situ hybridization were used to detect the changes of caveolin-1 gene and the protein in 92 TSCCs and their adjacent normal tissues. The data were analyzed with SPSS10.0 software package.
  
  
  RESULTS
  The expressions of caveolin-1 gene(24.6+/-1.8) and its protein(471.2+/-68.1) in TSCC were lower than those of the control group(167.2+/-20.5, 964.5+/-77.2), respectively. The difference was significant(P<0.01). The expression of caveolin-1 protein in well-differentiated TSCC(5.6+/-1.4) was higher than that in moderately and poorly differentiated TSCC(1.3+/-0.8); The expression of caveolin-1 protein in stage I-II patients(6.1+/-2.0) was higher than that in stage III-IV patients(2.4+/-0.7), and the difference was significant(P<0.01). There was no significant relationship between the expression of caveolin-1 protein and cervical lymph node metastasis(P>0.05).
  
  
  CONCLUSIONS
  The level of caveolin-1 gene and the expression of the protein decrease in TSCC and the level of protein has a significant relationship with the clinical stage and the pathological grade, rather than the cervical lymph node metastasis.
authors: Department of Stomatology, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China.
authors: Jun
authors: J
authors: Zhang
authors: Jin-zhao
authors: JZ
authors: Li
authors: Zhi-ming
authors: ZM
authors: Wang
authors: Li-ping
authors: LP
authors: Zhang
mesh_terms: D002294:Carcinoma, Squamous Cell; D051242:Caveolin 1 / Q000096:biosynthesis*; D006801:Humans; D008207:Lymphatic Metastasis; D009333:Neck; D009367:Neoplasm Staging; D011379:Prognosis; D014062:Tongue Neoplasms
chemical_list: C495540:CAV1 protein, human; D051242:Caveolin 1