title: Impaired glucose metabolism in women with polycystic ovary syndrome.
abstract: BACKGROUND
  To compare the prevalence of impaired glucose tolerance (IGT) and type 2 diabetes mellitus (T2DM) in lean and overweight/obese women with polycystic ovary syndrome (PCOS), with the data from a normal population sample.
  
  
  METHODS
  PCOS-affected women fulfilling ESHRE diagnostic criteria underwent an oral glucose tolerance test. Prevalence of IGT and T2DM in control sample of white healthy females was extracted from the published data from NHANES II.
  
  
  RESULTS
  In 225 women with PCOS, IGT was present in 6/104 (5.8%) lean and in 15/121 (12.4%) overweight/obese women. T2DM was present in 1/104 (1.0%) lean and in 3/121 (2.5%) overweight/obese PCOS women. In a sample of 643 women from NHANES II, the crude rate of IGT was 5.9%. IGT was significantly more common only in the overweight/obese PCOS subgroup as compared to the NHANES II cohort (chi(2) = 5.99, p < 0.01).
  
  
  CONCLUSIONS
  IGT was found significantly more frequently only in overweight/obese PCOS subjects in comparison with healthy controls.
authors: Institute of Endocrinology, General Faculty Hospital, Charles University, Prague, Czech Republic. jvrbikova@endo.cz
authors: Jana
authors: J
authors: Vrbikova
authors: Michal
authors: M
authors: Fanta
authors: David
authors: D
authors: Cibula
authors: Karel
authors: K
authors: Vondra
authors: Bela
authors: B
authors: Bendlova
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000453:epidemiology; D005260:Female; D018149:Glucose Intolerance / Q000097:blood*; D005951:Glucose Tolerance Test; D006801:Humans; D009765:Obesity / Q000097:blood; D011085:Polycystic Ovary Syndrome / Q000097:blood*; D015995:Prevalence; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D001786:Blood Glucose