Extent of neck dissection required after concurrent chemoradiation for stage IV head and neck squamous cell carcinoma.
BACKGROUND
The management of initially bulky nodal disease after primary nonsurgical treatment for stage IV head and neck squamous cell carcinoma (HNSCC) continues to be a subject of debate.


METHODS
A retrospective chart review of neck management in patients after chemoradiation was performed.


RESULTS
Of the initially positive necks analyzed, 210/329 (65%) had a complete clinical response to treatment and 161 necks underwent neck surgery. Patients were pathologically positive 13.8% and 39.6% of the time after clinical complete or partial response, respectively. Regional recurrence was more frequent in necks with partial clinical (p = .04) or pathologic responses (p < .01) and with primary site recurrences (p < .01).


CONCLUSIONS
It is still safest at our institution to perform selective neck dissection on patients with > or = N2 neck disease when initially observed to prevent unsalvageable regional recurrence until more accurate interval assessment tools are confirmed.
Cannady
Steven B
SB
Department of Otolaryngology, Oregon Health Sciences University, Portland, Oregon, USA. stevencannady@hotmail.com
Lee
Walter T
WT
Scharpf
Joseph
J
Lorenz
Robert R
RR
Wood
Benjamin G
BG
Strome
Marshall
M
Lavertu
Pierre
P
Esclamado
Ramon M
RM
Saxton
Jerrold P
JP
Adelstein
David J
DJ
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology* / Q000628:therapy*; D017024:Chemotherapy, Adjuvant; D015331:Cohort Studies; D018572:Disease-Free Survival; D005260:Female; D006258:Head and Neck Neoplasms / Q000401:mortality / Q000473:pathology* / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D037981:Neck Dissection; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control*; D009367:Neoplasm Staging; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D015996:Survival Rate; D055815:Young Adult