title: Adjunctive topiramate treatment for a refractory familial adolescent mania.
abstract: Adolescent mania is often misdiagnosed. This case study describes the clinical course and diagnostic reclassification from schizophrenia to bipolar disorder in a 15-year-old girl. This case study also describes the pedigree of the siblings, familial aggregation, and anticipation of mood disorders. In addition, we present the successful use of topiramate, a new antiepileptic drug, which is increasingly being used as a mood stabilizer in paediatric bipolar disorder. The efficacy of topiramate in this case supports its role as a promising agent in treatment-resistant adolescent mania associated with familial aggregation.
authors: For-Wey
authors: FW
authors: Lung
authors: Chun-Lin
authors: CL
authors: Liu
authors: Chien-Shu
authors: CS
authors: Wang
authors: Dong-Sheng
authors: DS
authors: Tzeng
mesh_terms: D000293:Adolescent; D017668:Age of Onset; D020132:Anticipation, Genetic; D000927:Anticonvulsants / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D003865:Major Depressive Disorder / Q000235:genetics; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D005190:Family; D005260:Female; D005632:Fructose / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D018020:Lithium Compounds / Q000627:therapeutic use; D010375:Pedigree; D012559:Schizophrenia / Q000175:diagnosis; D000077236:Topiramate; D016896:Treatment Outcome
chemical_list: D000927:Anticonvulsants; D018020:Lithium Compounds; D000077236:Topiramate; D005632:Fructose