title: Exposure to SIVmnd-2 in southern Cameroon: public health implications.
abstract: Compelling evidence appeared in 2002 of human exposure to a plethora of primate lentiviruses through hunting, handling of bushmeat, and/or animals kept as pets in Cameroon. To determine SIV prevalence in pet animals, an analysis of 28 sera of nonhuman primates found no SIV infection in greater spot-nosed monkeys (0/5) or chimpanzees (0/10), and a prevalence rate of 23.1% (3/13) in mandrills kept as household pets in southern Cameroon. Phylogenetical analysis based on pol-integrase region and mitochondrial cytochrome b gene showed that the newly found SIV from Mandrillus sphinx (SIVmndCM-202, SIVmndCM-211, and SIVmndCM-218) clustered significantly with SIVmnd-2. Questionnaire data were also collected to assess whether owners had experienced bites, scratches, or exposure to blood and/or body fluid. Risk to human health from cross-species transmission of the newly identified SIVmnd-2 to infect humans remains unknown.
authors: Department of Hematology and Virology, Faculty of Medicine and Biomedical Sciences, University of Yaoundé, Yaoundé, Cameroon. ndembinic@yahoo.fr
authors: Nicaise
authors: N
authors: Ndembi
authors: Lazare
authors: L
authors: Kaptue
authors: Eiji
authors: E
authors: Ido
mesh_terms: D000818:Animals; D001733:Bites and Stings; D002163:Cameroon / Q000453:epidemiology; D000882:Haplorhini / Q000821:virology; D006801:Humans; D048528:Mandrillus / Q000821:virology; D002679:Pan troglodytes / Q000821:virology; D010802:Phylogeny; D015995:Prevalence; D016097:Simian Acquired Immunodeficiency Syndrome / Q000453:epidemiology*; D015302:Simian Immunodeficiency Virus / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D011795:Surveys and Questionnaires; D014764:Viral Proteins / Q000235:genetics
chemical_list: D014764:Viral Proteins