Late effects of treatment for wilms tumor.
Advancements in surgery, radiotherapy, and chemotherapy have greatly improved the cures rates for children with Wilms tumor. However, a number of therapy-related late effects have been observed in long-term survivors. Generally, late complications are a consequence of treatment type and intensity; the use of radiotherapy and anthracyclines increases the risk of these complications. This commentary highlights some clinically significant late sequelae-musculoskeletal effects, cardiac toxicity, reproductive problems, renal dysfunction, and the development of second malignant neoplasms. Careful medical and epidemiological monitoring of survivors can provide critical information to further optimize therapy while minimizing long-term sequelae.
Wright
Karen D
KD
Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105-3678, USA. karen.wright@stjude.org
Green
Daniel M
DM
Daw
Najat C
NC
D000970:Antineoplastic Agents / Q000009:adverse effects*; D003131:Combined Modality Therapy; D006331:Heart Diseases / Q000209:etiology; D006801:Humans; D007680:Kidney Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D009140:Musculoskeletal Diseases / Q000209:etiology; D016609:Neoplasms, Second Primary / Q000209:etiology; D011878:Radiotherapy / Q000009:adverse effects*; D012098:Reproduction / Q000187:drug effects / Q000528:radiation effects; D009396:Wilms Tumor / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*
D000970:Antineoplastic Agents