title: Polymorphism of the serotonin transporter gene modulates brain and physiological responses to acute stress in Japanese men.
abstract: A short (S) variant, compared to a long (L) variant, of the promoter region of the serotonin transporter gene-linked polymorphic region (5HTTLPR) has been related to emotional hyper-reactivity. We tested whether the 5HTTLPR could modulate acute stress responses in the brain and, the cardiovascular and neuroendocrine systems. Ten Japanese male participants carrying double copies of the S alleles and 10 Japanese males carrying S and L alleles conducted a mental arithmetic task, and their regional cerebral blood flow by (15)O positron emission tomography and cardiovascular and neuroendocrine parameters were measured. During the acute stress task, the participants with the SS alleles showed stronger reactivity in blood pressure and secretion of epinephrine, compared to the participants with the SL and LL alleles. Furthermore, the SS carriers showed greater activation in stress-related brain regions such as the hypothalamus, cerebellum, midbrain, and pulvinar compared to the SL and LL carriers during the acute stress task. The present findings indicated that the S allele of the 5HTTLPR is associated with greater brain and physiological reactivity to acute stress in Japanese men.
authors: Department of Psychology, Nagoya University, Nagoya, Japan. ohira@lit.nagoya-u.ac.jp
authors: Hideki
authors: H
authors: Ohira
authors: Masahiro
authors: M
authors: Matsunaga
authors: Tokiko
authors: T
authors: Isowa
authors: Michio
authors: M
authors: Nomura
authors: Naho
authors: N
authors: Ichikawa
authors: Kenta
authors: K
authors: Kimura
authors: Noriaki
authors: N
authors: Kanayama
authors: Hiroki
authors: H
authors: Murakami
authors: Takahiro
authors: T
authors: Osumi
authors: Toshihiro
authors: T
authors: Konagaya
authors: Tsuyoshi
authors: T
authors: Nogimori
authors: Seisuke
authors: S
authors: Fukuyama
authors: Jun
authors: J
authors: Shinoda
authors: Jitsuhiro
authors: J
authors: Yamada
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics; D001794:Blood Pressure / Q000235:genetics / Q000502:physiology; D001921:Brain; D004837:Epinephrine / Q000502:physiology; D006801:Humans; D007031:Hypothalamus / Q000502:physiology; D008297:Male; D011110:Polymorphism, Genetic; D049268:Positron-Emission Tomography; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D013315:Stress, Psychological / Q000235:genetics / Q000503:physiopathology*; D055815:Young Adult
chemical_list: D050486:Serotonin Plasma Membrane Transport Proteins; D004837:Epinephrine