title: Influence of KGF on the progression of pancreatic cancer.
abstract: BACKGROUND
  Keratinocyte growth factor (KGF increases the proliferation and motility of many epithelial cells and is known to be up-regulated in pancreatic cancer. The present study examined the hypothesis that KGF may initiate or enhance the progression of pancreatic cancer by increasing the proliferation and motility of pancreatic cancer cells.
  
  
  METHODS
  HPAF-II pancreatic cancer cell migration and proliferation was evaluated using a culture wounding assay 24 and 48 hours following KGF treatment. KGF receptor (KGFR) localization in these cells was established by immunohistochemistry.
  
  
  RESULTS
  KGF treatment significantly increased the proliferation and motility of the HPAF-II cells. In addition, KGF enhanced the motile morphology of these cancer cells.
  
  
  CONCLUSIONS
  The results of this study indicate that KGF has a rapid influence on the proliferation and motility of HPAF-II cells and suggest that KGF may be involved in the progression of pancreatic cancer.
authors: Department of Pharmaceutical Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73117, USA.
authors: Xiao-Ping
authors: XP
authors: Zang
authors: Megan
authors: M
authors: Lerner
authors: Daniel
authors: D
authors: Brackett
authors: J Thomas
authors: JT
authors: Pento
mesh_terms: D002448:Cell Adhesion; D002465:Cell Movement; D049109:Cell Proliferation; D051523:Fibroblast Growth Factor 7 / Q000494:pharmacology*; D006801:Humans; D007124:Immunoenzyme Techniques; D010190:Pancreatic Neoplasms / Q000378:metabolism / Q000473:pathology*; D051497:Receptor, Fibroblast Growth Factor, Type 2 / Q000378:metabolism; D014407:Tumor Cells, Cultured
chemical_list: D051523:Fibroblast Growth Factor 7; D051497:Receptor, Fibroblast Growth Factor, Type 2; C065104:keratinocyte growth factor receptor