[Application of self-assembling peptide nanofiber scaffold in nerve tissue engineering].
OBJECTIVE
To review the fundamental research and the experimental study in the nerve tissue engineering of self-assembling peptide nanofiber scaffold (SAPNS).


METHODS
The literature concerning basic and experimental studies on SAPNS in the nerve tissue engineering was extensively reviewed.


RESULTS
SAPNS can promote the neural stem cell adhesion, proliferation, differentiation and neuron axon outward growth and extension, promote extracellular matrix synthesis and inhibit glial cell adhesion and differentiation, and simulate the environment of a cell in the body.


CONCLUSIONS
SAPNS is an ideal matrix material and provides a new way for the repair of nerve tissue injury.
Wang
Baichuan
B
Department of Orthopedics, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan Hubei, 430027, P.R. China.
Shao
Zengwu
Z
D001672:Biocompatible Materials; D057139:Nanofibers; D009416:Nerve Regeneration; D010455:Peptides; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds
D001672:Biocompatible Materials; D010455:Peptides