Association between MTHFR 677C-T polymorphism and alcohol dependence according to Lesch and Babor typology.
Prior studies have associated 677C-T Methylenetetrahydrofolate reductase (MTHFR) gene polymorphism with decreased enzymatic activity and modified homocysteine regulation. This study determines and compares MTHFR 677C-T distribution and examines its consequences on homocysteine metabolism and alcohol dependence in alcoholic patients classified according to the Babor and Lesch typologies. MTHFR TT genotype was more prevalent in AD patients with milder alcohol dependence (Babor type A) and with Lesch type 3, associated with depression. MTHFR TT was also associated with hyperhomocysteinemia. Determining MTHFR 677C-T genotype, folate and vitamin B12 levels could assist physicians in identifying type 3 patients and improve addictions management.
Benyamina
Amine
A
Service d'Addictologie, Hôpital Paul Brousse, Paul Vaillant Couturier, Villejuif Cedex, Assistance Publique-Hôpitaux de Paris, France. amine.benyamina@pbr.aphp.fr
Saffroy
Raphaël
R
Blecha
Lisa
L
Pham
Patrick
P
Karila
Laurent
L
Debuire
Brigitte
B
Lemoine
Antoinette
A
Reynaud
Michel
M
D000328:Adult; D000437:Alcoholism / Q000145:classification* / Q000453:epidemiology / Q000235:genetics*; D003866:Depressive Disorder / Q000453:epidemiology; D005260:Female; D005838:Genotype; D006710:Homocysteine / Q000097:blood; D006801:Humans; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D014805:Vitamin B 12 / Q000097:blood
D006710:Homocysteine; D042965:Methylenetetrahydrofolate Reductase (NADPH2); D014805:Vitamin B 12