title: Immunosuppressive HLA-G molecule is upregulated in alveolar epithelial cells after influenza A virus infection.
abstract: Influenza virus type A (IAV) infections constitute an important economic burden and raise health-care problems. Host defense mechanisms usually clear IAV infections after a few days by exploiting a variety of cellular immune responses. However, increasing the production of immunosubversive molecules is a mechanism by which viruses escape host surveillance. In this regard, the nonclassical HLA class I molecule HLA-G displays strong tolerogenic properties. We show here that several strains of IAV differently upregulate HLA-G expression, at both the mRNA and protein levels, in alveolar epithelial cells. Thus the virulence of IAV may be caused by the capability of different strains to upregulate HLA-G allowing their escape from host immune responses.
authors: Unité de Virologie et Immunologie Moléculaires, UR 892 INRA, Domaine de Vilvert, 78352 Jouy-en-Josas, France.
authors: Fanny
authors: F
authors: LeBouder
authors: Khaled
authors: K
authors: Khoufache
authors: Catherine
authors: C
authors: Menier
authors: Yassmina
authors: Y
authors: Mandouri
authors: Mahmoud
authors: M
authors: Keffous
authors: Nathalie
authors: N
authors: Lejal
authors: Irène
authors: I
authors: Krawice-Radanne
authors: Edgardo D
authors: ED
authors: Carosella
authors: Nathalie
authors: N
authors: Rouas-Freiss
authors: Béatrice
authors: B
authors: Riteau
mesh_terms: D000818:Animals; D002460:Cell Line; D004285:Dogs; D006680:HLA Antigens / Q000032:analysis / Q000096:biosynthesis*; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000032:analysis / Q000096:biosynthesis*; D006801:Humans; D007108:Immune Tolerance; D009980:Influenza A virus / Q000276:immunology*; D007251:Influenza, Human / Q000276:immunology*; D011650:Pulmonary Alveoli / Q000276:immunology* / Q000821:virology; D012333:RNA, Messenger / Q000276:immunology / Q000378:metabolism; D020545:Respiratory Mucosa / Q000276:immunology / Q000821:virology; D015854:Up-Regulation
chemical_list: D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I; D012333:RNA, Messenger