Age-associated motor and visuo-spatial learning phenotype in Dyrk1A heterozygous mutant mice.
Dual-specificity tyrosine-regulated kinase 1A (DYRK1A) is a candidate gene for the Down syndrome neurological defects and may be involved in the progression of Alzheimer's disease. Heterozygous mice for Dyrk1A (Dyrk1A+/-) exhibit decreased brain size, motor abnormalities and cognitive deficits in the adult. However, there is no information about the mutant phenotype in old ages. Here we analyze the impact of Dyrk1A dosage reduction on motor performance and hippocampal-dependent learning and memory in aged Dyrk1A+/- mice. Whereas motor tests showed marked alterations in traction ability, prehensile reflex and balance, heterozygous mice only present a slight impairment of visuo-spatial memory even though they show a robust decrease of CA1-CA3 and dentate gyrus cells.
Arqué
Glòria
G
Genes and Disease Program, Center for Genomic Regulation (CRG), Pompeu Fabra University, Barcelona Biomedical Research Park (PRBB) and CIBER de Enfermedades Raras (CIBERER), Barcelona, Spain.
de Lagrán
María Martínez
MM
Arbonés
Maria L
ML
Dierssen
Mara
M
D000375:Aging / Q000235:genetics*; D000818:Animals; D001921:Brain / Q000473:pathology; D003072:Cognition Disorders / Q000235:genetics; D005260:Female; D006580:Genetic Carrier Screening; D007858:Learning / Q000502:physiology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008818:Mice, Neurologic Mutants; D009043:Motor Activity / Q000235:genetics*; D009154:Mutation / Q000502:physiology; D009929:Organ Size / Q000235:genetics; D010641:Phenotype; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D011505:Protein-Tyrosine Kinases / Q000235:genetics*; D011597:Psychomotor Performance / Q000502:physiology; D013037:Spatial Behavior / Q000502:physiology; D000097603:Dyrk Kinases
D017346:Protein Serine-Threonine Kinases; D011505:Protein-Tyrosine Kinases; D000097603:Dyrk Kinases