title: Calbindin-1 association and Parkinson's disease.
abstract: OBJECTIVE
  Calcium levels have been proposed to play an important role in the selective vulnerability of nigrostriatal dopaminergic neurons in Parkinson's disease (PD). Recently, an association was reported between the calcium buffer, calbindin (rs1805874) and risk of PD in a Japanese patient-control series.
  
  
  METHODS
  We genotyped rs1805874 in four independent Caucasian patient-control series (1543 PD patients, 1771 controls).
  
  
  RESULTS
  There was no evidence of an association between rs1805874 and disease risk in individual populations or in the combined series (odds ratio: 1.04, 95% CI: 0.82-1.31, P = 0.74).
  
  
  CONCLUSIONS
  Our study shows there is no association between rs1805874 and risk for PD in four Caucasian populations. This suggests the effect of calbindin on PD risk displays population specificity.
authors: Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL, USA.
authors: A I
authors: AI
authors: Soto-Ortolaza
authors: B
authors: B
authors: Behrouz
authors: C
authors: C
authors: Wider
authors: C
authors: C
authors: Vilariño-Güell
authors: M G
authors: MG
authors: Heckman
authors: J O
authors: JO
authors: Aasly
authors: J
authors: J
authors: Mark Gibson
authors: T
authors: T
authors: Lynch
authors: B
authors: B
authors: Jasinska-Myga
authors: A
authors: A
authors: Krygowska-Wajs
authors: G
authors: G
authors: Opala
authors: M
authors: M
authors: Barcikowska
authors: K
authors: K
authors: Czyzewski
authors: R J
authors: RJ
authors: Uitti
authors: Z K
authors: ZK
authors: Wszolek
authors: M J
authors: MJ
authors: Farrer
authors: O A
authors: OA
authors: Ross
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D064092:Calbindin 1; D064026:Calbindins; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D007494:Ireland; D008297:Male; D008875:Middle Aged; D009664:Norway; D010300:Parkinson Disease / Q000235:genetics*; D011044:Poland; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D064030:S100 Calcium Binding Protein G / Q000235:genetics*; D017422:Sequence Analysis, DNA; D014481:United States; D044465:White People / Q000235:genetics
chemical_list: C576498:CALB1 protein, human; D064092:Calbindin 1; D064026:Calbindins; D064030:S100 Calcium Binding Protein G