[Influence of adjuvant therapy on survival of patients with pancreatic carcinoma of body and tail: a report of 137 cases].
OBJECTIVE
To investigate the effect of adjuvant therapy on the treatment of carcinoma of the body and tail of pancreas.


METHODS
The clinical data of 137 patients with carcinoma of the body and tail of pancreas, 91 males and 46 females, aged 58.9 (24 - 76), of which 38 underwent radical resection, 24 underwent palliative resection, and 75 did not undergo resection, and 58 of which underwent adjuvant therapy, were analyzed.


RESULTS
The overall 3-year survival rate was 10.7% for the whole group, 27.3% for the radical resection group, 4.2% for the palliative resection, and 4.5% for the no resection group. The median survival time (MST) was 8 months for the whole group, 15 months for the radical resection group, 8 months for the palliative resection group, and 6 months for the no resection group. The 3-year survival rate was 13.9% for the patients undergoing adjuvant therapy and 7.2% for those without adjuvant therapy, and the MST was 11 months for those undergoing adjuvant therapy, and 5 months for those without adjuvant therapy. Intra-arterial therapy and radiation therapy were protective factors for those whose cancerous tissues were not radically resected (OR = 1.56, 95% CI: 1.04 - 2.35, P = 0.033).


CONCLUSIONS
Adjuvant therapy significantly improves the survival of the patients with pancreatic carcinoma of the body and tail. The clinical effect of intra-arterial therapy is better than those of radiation therapy and chemotherapy.
Xie
Yi-bin
YB
Department of Abdominal Surgical Oncology, Cancer Hospital and Institute, Chinese Academy of Medical Science, Beijing 100021, China.
Wang
Cheng-feng
CF
Li
Chen-rui
CR
Shan
Yi
Y
Zhao
Dong-bing
DB
Tian
Yan-tao
YT
Zhao
Ping
P
D000328:Adult; D000368:Aged; D017024:Chemotherapy, Adjuvant; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009367:Neoplasm Staging; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000401:mortality* / Q000473:pathology; D011184:Postoperative Period; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome; D055815:Young Adult