Biomedicinal implications of high-density lipoprotein: its composition, structure, functions, and clinical applications.
High-density lipoprotein (HDL) is a proven biomarker for the monitoring of changes in antioxidant and anti-inflammation capability of body fluids. The beneficial virtues of HDL are highly dependent on its lipids and protein compositions, and their ratios. In normal state, the HDL particle is enriched with lipids and several HDL-associated enzymes, which are responsible for its antioxidant activity. Lower HDL-cholesterol levels (40 mg/dL) have been recognized as an independent risk factor for coronary artery disease, as well as being a known component of metabolic syndrome. Functional and structural changes of HDL have been recognized as factors pivotal to the evaluation of HDL-quality. In this review, I have elected to focus on the functional and structural correlations of HDL and the roles of HDL-associated apolipoproteins and enzymes. Recent clinical applications of HDL have also been reviewed, particularly the therapeutic targeting of HDL metabolism and reconstituted HDL; these techniques represent promising emerging strategies for the treatment of cardiovascular disease, for drug or gene therapy.
Cho
Kyung-Hyun
KH
School of Biotechnology, Yeungnam University, Gyeongsan 712-749, Korea. chok@yu.ac.kr
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000975:Antioxidants / Q000627:therapeutic use; D001053:Apolipoproteins / Q000378:metabolism / Q000502:physiology; D043303:Aryldialkylphosphatase / Q000378:metabolism / Q000502:physiology; D050197:Atherosclerosis / Q000517:prevention & control; D020811:Biomedical Technology / Q000379:methods; D053480:Cholesterol Ester Transfer Proteins / Q000378:metabolism / Q000502:physiology; D016503:Drug Delivery Systems / Q000379:methods; D006801:Humans; D008075:Lipoproteins, HDL / Q000737:chemistry* / Q000378:metabolism / Q000502:physiology* / Q000627:therapeutic use*; D008954:Models, Biological; D007862:Phosphatidylcholine-Sterol O-Acyltransferase / Q000378:metabolism / Q000502:physiology
D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D001053:Apolipoproteins; D053480:Cholesterol Ester Transfer Proteins; D008075:Lipoproteins, HDL; D007862:Phosphatidylcholine-Sterol O-Acyltransferase; D043303:Aryldialkylphosphatase