[Hodgkin's disease, fertility and pregnancy].
Hodgkin's disease, the most common cancer between 15 and 24 years, raises two problems in women in reproductive age: the preservation of fertility and the care during pregnancy. Chemotherapy and radiotherapy can destroy gonads and subsequently lead to a loss of fertility and premature ovarian failure. Many options are available today to maintain fertility in female patients treated for Hodgkin's disease, thanks to advances in assisted-reproduction technology. Chemotherapy and radiotherapy during the first trimester are associated with increased risk of congenital malformations and this risk diminishes as pregnancy advances. The management of this disease during pregnancy must be examined case by case.
Larguèche
K
K
Service de Gynécologie-Obstétrique et de Médecine de la Reproduction, Hôpital Aziza-Othmana, La Kasba, Tunis, Tunisie. kamel_180@hotmail.com
Laârif
Z
Z
Ferchiou
M
M
D000970:Antineoplastic Agents / Q000009:adverse effects*; D000013:Congenital Abnormalities / Q000209:etiology*; D005260:Female; D006689:Hodgkin Disease / Q000150:complications / Q000628:therapy*; D006801:Humans; D007247:Infertility, Female / Q000209:etiology* / Q000517:prevention & control; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000628:therapy*; D011878:Radiotherapy / Q000009:adverse effects*
D000970:Antineoplastic Agents