title: Gastroprotection of (-)-alpha-bisabolol on acute gastric mucosal lesions in mice: the possible involved pharmacological mechanisms.
abstract: (-)-Alpha-Bisabolol is an unsaturated, optically active sesquiterpene alcohol obtained by the direct distillation essential oil from plants such as Vanillosmopsis erythropappa and Matricaria chamomilla. (-)-Alpha-Bisabolol has generated considerable economic interest, since it possesses a delicate floral odor and has been shown to have anti-septic and anti-inflammatory activity. The aim of this work was to evaluate the gastroprotective action of (-)-alpha-bisabolol on ethanol and indomethacin-induced ulcer models in mice, and further investigate the pharmacological mechanisms involved in this action. The oral administration of (-)-alpha-bisabolol 100 and 200 mg/kg was able to protect the gastric mucosa from ethanol (0.2 mL/animal p.o.) and indomethacin-induced ulcer (20 mg/kg p.o.). Administration of L-NAME (10 mg/kg i.p.), glibenclamide (10 mg/kg i.p.) or indomethacin (10 mg/kg p.o.) was not able to revert the gastroprotection promoted by (-)-alpha-bisabolol 200 mg/kg on the ethanol-induced ulcer. Dosage of gastric reduced glutathione (GSH) levels showed that ethanol and indomethacin reduced the content of non-protein sulfhydryl (NP-SH) groups, while (-)-alpha-bisabolol significantly decreased the reduction of these levels on ulcer-induced mice, but not in mice without ulcer. In conclusion, gastroprotective effect on ethanol and indomethacin-induced ulcer promoted by (-)-alpha-bisabolol may be associated with an increase of gastric sulfydryl groups bioavailability leading to a reduction of gastric oxidative injury induced by ethanol and indomethacin.
authors: Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Rua Cel Nunes de Melo 1127, CEP 60430-270 Fortaleza, Brazil.
authors: Nayrton Flávio
authors: NF
authors: Moura Rocha
authors: Edith Teles
authors: ET
authors: Venâncio
authors: Brinell Arcanjo
authors: BA
authors: Moura
authors: Maria Izabel
authors: MI
authors: Gomes Silva
authors: Manoel Rufino
authors: MR
authors: Aquino Neto
authors: Emiliano Ricardo
authors: ER
authors: Vasconcelos Rios
authors: Damião Pergentino
authors: DP
authors: de Sousa
authors: Silvânia Maria
authors: SM
authors: Mendes Vasconcelos
authors: Marta Maria
authors: MM
authors: de França Fonteles
authors: Francisca Cléa Florenço
authors: FC
authors: de Sousa
mesh_terms: D000818:Animals; D000897:Anti-Ulcer Agents / Q000008:administration & dosage / Q000494:pharmacology*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000633:toxicity; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology; D005978:Glutathione / Q000378:metabolism; D007213:Indomethacin / Q000633:toxicity; D008297:Male; D051379:Mice; D023421:Models, Animal; D000081222:Monocyclic Sesquiterpenes; D010437:Peptic Ulcer / Q000473:pathology / Q000517:prevention & control*; D012717:Sesquiterpenes / Q000008:administration & dosage / Q000494:pharmacology*; D013438:Sulfhydryl Compounds / Q000378:metabolism
chemical_list: D000897:Anti-Ulcer Agents; D000081222:Monocyclic Sesquiterpenes; D012717:Sesquiterpenes; D013438:Sulfhydryl Compounds; C004497:bisabolol; D000431:Ethanol; D005978:Glutathione; D007213:Indomethacin