Significant synergistic effect of peroxisome proliferator-activated receptor gamma C-2821T and diabetes on the risk of ischemic stroke.
OBJECTIVE
To explore the relationship between the genetic polymorphisms of PPARgamma (Pro12Ala, C1431T, and C-2821T) and the risk of ischemic stroke and to investigate whether these genetic polymorphisms of PPARgamma would modify the risk of ischemic stroke among patients with hypertension or diabetes.


METHODS
The case-control study was conducted with 537 ischemic stroke patients and 537 control subjects. A structured questionnaire was used to collect information on conventional cardiovascular risk factors and laboratory results. The genetic polymorphisms of PPARgamma were determined by PCR-restriction fragment-length polymorphism.


RESULTS
A significant interaction was seen between the -2821C allele and diabetes but not between this allele and hypertension. A markedly elevated risk of ischemic stroke (odds ratio 9.7) was found in the subjects with diabetes and the -2821C allele compared with that in those without these two risk factors.


CONCLUSIONS
The -2821C allele of PPARgamma was a strong predictor of ischemic stroke for diabetic patients.
Hsieh
Fang-I
FI
School of Public Health, Taipei Medical University, Taipei, Taiwan.
Lo
Wei-Cheng
WC
Lin
Huey-Juan
HJ
Hsieh
Yi-Chen
YC
Lien
Li-Ming
LM
Bai
Chyi-Huey
CH
Tseng
Hung-Pin
HP
Chiou
Hung-Yi
HY
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019943:Amino Acid Substitution; D003925:Diabetic Angiopathies / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D016017:Odds Ratio; D047495:PPAR gamma / Q000235:genetics*; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D011237:Predictive Value of Tests; D012307:Risk Factors; D020521:Stroke / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000235:genetics* / Q000473:pathology; D014057:Tomography, X-Ray Computed
D047495:PPAR gamma