Smooth endoplasmic reticulum aggregations in all retrieved oocytes causing recurrent multiple anomalies: case report.
OBJECTIVE
To document the relationship between smooth endoplasmic reticulum (SER) aggregations and recurrent fetal anomalies.


METHODS
Case report.


METHODS
Private IVF center.


METHODS
A 28-year-old woman with an 11-year history of primary infertility.


METHODS
Three consecutive cycles of intracytoplasmic sperm injection (ICSI) in the same patient.


METHODS
Clinical pregnancy, live birth, fetal anomaly.


RESULTS
In three consecutive ICSI cycles, a total of 59 MII oocytes were retreived in the same patient, all displaying SER aggregations. The fertilization rate per cycle was 80%, 50%, and 42%, respectively. A total of 12 embryos were transferred in three ICSI cycles, of which 11 were grade 1 embryos. Two of the three cycles ended up with clinical ongoing pregnancies but with multiple fetal anomalies.


CONCLUSIONS
This is the first case reported with SER aggregations in all retrieved oocytes in three consecutive ICSI cycles. The repetetive multiple fetal anomalies possibly related to oocyte dysmorphism are of concern.
Akarsu
Cem
C
Ankara Private IVF Center, Ankara, Turkey.
Çağlar
Gamze
G
Ankara Private IVF Center, Ankara, Turkey; Present address: Department of Obstetrics and Gynecology, Ufuk University Faculty of Medicine, Ankara, Turkey. Electronic address: gamzesinem@hotmail.com.
Vicdan
Kubilay
K
Ankara Private IVF Center, Ankara, Turkey.
Sözen
Eran
E
Ankara Private IVF Center, Ankara, Turkey.
Biberoğlu
Kutay
K
Department of Obstetrics and Gynecology, Gazi University Faculty of Medicine, Ankara, Turkey.
D000015:Abnormalities, Multiple / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D000328:Adult; D018871:Endoplasmic Reticulum, Smooth / Q000473:pathology*; D005260:Female; D006801:Humans; D007246:Infertility / Q000209:etiology; D008297:Male; D054315:Oocyte Retrieval; D009865:Oocytes / Q000473:pathology* / Q000648:ultrastructure; D011247:Pregnancy; D012008:Recurrence; D020554:Sperm Injections, Intracytoplasmic