title: [Study on the tissue distribution of berberine from Rhizoma Coptidis and compatibility with Rhizoma Coptidis and Cortex Cinnamomi in rats].
abstract: OBJECTIVE
  To study the effects of Rhizoma Coptidis extracts and Rhizoma Coptidis and Cortex Cinnamomi extracts on the distribution of terberine in rats' tissues.
  
  
  METHODS
  The rats were intragastrically given the two different extracts. HPLC was used to determine the concentration of berberine in rats' tissues and the sample was extracted by liquid-liquid extraction method.
  
  
  RESULTS
  At the same time, with the same gavage of the three extracts, the trend of the berberine in rats was: the concentration of Rhizoma Coptidis and Cortex Cinnamomi extracts > the concentration of Rhizoma Coptidis extracts.
  
  
  CONCLUSIONS
  Berberine can be detected in intestinal, stomach, colon, pancreatic, heart, kidney, liver, spleen, lung, testicular, uterus, especially the gastrointestinal system with higher concentration, so berberine has a wide range of distribution in vivo.
authors: Pharmacy College, Liaoning University of TCM, Dalian 116600, China. yqn-413@163.com
authors: Qiao-Na
authors: QN
authors: Yan
authors: Shuo
authors: S
authors: Zhang
authors: Zhen-Qiu
authors: ZQ
authors: Zhang
mesh_terms: D000818:Animals; D001599:Berberine / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D039323:Coptis / Q000737:chemistry; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D005260:Female; D041981:Gastrointestinal Tract / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000378:metabolism; D019770:Lauraceae / Q000737:chemistry; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008297:Male; D024301:Plant Bark / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D014018:Tissue Distribution
chemical_list: D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D001599:Berberine