title: Functional assessment after sciatic nerve injury in a rat model.
abstract: The aim of this study is to evaluate the effectiveness of Sciatic Function Index (SFI) and Basso, Beattie, and Bresnahan (BBB) Locomotor Rating in assessing peripheral nerve injuries. SFI is a standard method for evaluating crush and transected peripheral nerve injuries, likewise BBB for spinal cord injury. Models of chronic nerve compression (CNC), crush, and transection injury were created on Sprague-Dawley rats and functional outcomes were measured using BBB and SFI at 1-week interval for 6 weeks. All injury models showed high correlation between SFI and BBB scores. With crush injury, the SFI showed near complete recovery while BBB showed residual deficits 6 weeks after injury. Both the BBB and SFI were unable to detect motor deficits in 6-week CNC animals. The BBB score should be considered as an adjunct in evaluating peripheral nerve recovery and may be more sensitive in detecting residual deficits than SFI after crush-type injuries.
authors: Department of Orthopaedic Surgery, University of California, Irvine, CA 92697, USA.
authors: Paul
authors: P
authors: Dinh
authors: Antony
authors: A
authors: Hazel
authors: Winnie
authors: W
authors: Palispis
authors: Sourabh
authors: S
authors: Suryadevara
authors: Ranjan
authors: R
authors: Gupta
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D008297:Male; D009409:Nerve Crush; D051381:Rats; D017207:Rats, Sprague-Dawley; D020127:Recovery of Function / Q000502:physiology*; D012584:Sciatic Nerve / Q000293:injuries* / Q000503:physiopathology