Animal models in infection and inflammation - chance and necessity.
In biomedical research, to understand pathogenesis and test innovative therapeutic strategies, animal models of human disease are a bare necessity. We cannot do without them, but could we do better with them? In this issue of the European Journal of Immunology a series of Viewpoints discusses the pros and cons of currently available animal models that address the clinical challenges of immunology in infection and inflammatory diseases.
Radbruch
Andreas
A
Deutsches Rheuma-Forschungszentrum Berlin, a Leibniz Institute, Berlin, Germany. radbruch@drfz.de
Isaacs
John
J
D000818:Animals; D003141:Communicable Diseases / Q000209:etiology / Q000276:immunology*; D004195:Disease Models, Animal; D006801:Humans; D007249:Inflammation / Q000209:etiology / Q000276:immunology*