Asthma mortality and long-acting beta2-agonists in five major European countries, 1994-2004.
OBJECTIVE
Over the last few decades, important changes occurred in the pharmacological approach to asthma control. However, the possible link between pharmacologic treatment and asthma death remains controversial.


METHODS
Age-standardized asthma mortality rates were computed over the 1994-2004 period for France, Germany, Spain, the UK, and Italy. Rates for children and young adults 5 to 34 years of age, middle age adults 35 to 64 years of age, and elderly adults > or = 65 years. Joinpoint regression was performed to identify years where significant changes in mortality trends occurred. Consumption of inhaled long-acting beta-2-agonists (LABA), including inhaled corticosteroids (ICS) when combined with LABAs in a single inhaler, derived from sales estimates.


RESULTS
In 1994, the highest asthma mortality rates were in Germany (4.7/100,000), and the lowest ones were in Italy and Spain (0.5/100,000). Steady downward trends were observed in all the countries considered. The largest decline was registered in Germany and the smallest one was in the UK. LABA sales increased steadily since 1994, particularly in France, Spain, and the UK, reaching values around 14 Defined Daily Doses (DDD)/1,000 inhabitants in 2004.


CONCLUSIONS
While the use of LABAs (with or without ICS) increased over the last decade, asthma mortality declined in major western European countries.
Chatenoud
Liliane
L
Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy. liliana@marionegri.it
Malvezzi
Matteo
M
Pitrelli
Andrea
A
La Vecchia
Carlo
C
Bamfi
Francesco
F
D000280:Administration, Inhalation; D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage; D058666:Adrenergic beta-2 Receptor Agonists; D000328:Adult; D017677:Age Distribution; D000368:Aged; D001249:Asthma / Q000188:drug therapy* / Q000401:mortality*; D002648:Child; D002675:Child, Preschool; D003692:Delayed-Action Preparations; D004338:Drug Combinations; D005260:Female; D005602:France / Q000453:epidemiology; D005858:Germany / Q000453:epidemiology; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009026:Mortality / Q000639:trends; D017678:Sex Distribution; D013030:Spain / Q000453:epidemiology; D006113:United Kingdom / Q000453:epidemiology; D055815:Young Adult
D000305:Adrenal Cortex Hormones; D058666:Adrenergic beta-2 Receptor Agonists; D003692:Delayed-Action Preparations; D004338:Drug Combinations