title: Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer.
abstract: We conducted a two-stage genome-wide association study of pancreatic cancer, a cancer with one of the lowest survival rates worldwide. We genotyped 558,542 SNPs in 1,896 individuals with pancreatic cancer and 1,939 controls drawn from 12 prospective cohorts plus one hospital-based case-control study. We conducted a combined analysis of these groups plus an additional 2,457 affected individuals and 2,654 controls from eight case-control studies, adjusting for study, sex, ancestry and five principal components. We identified an association between a locus on 9q34 and pancreatic cancer marked by the SNP rs505922 (combined P = 5.37 x 10(-8); multiplicative per-allele odds ratio 1.20; 95% confidence interval 1.12-1.28). This SNP maps to the first intron of the ABO blood group gene. Our results are consistent with earlier epidemiologic evidence suggesting that people with blood group O may have a lower risk of pancreatic cancer than those with groups A or B.
authors: Laufey
authors: L
authors: Amundadottir
authors: Peter
authors: P
authors: Kraft
authors: Rachael Z
authors: RZ
authors: Stolzenberg-Solomon
authors: Charles S
authors: CS
authors: Fuchs
authors: Gloria M
authors: GM
authors: Petersen
authors: Alan A
authors: AA
authors: Arslan
authors: H Bas
authors: HB
authors: Bueno-de-Mesquita
authors: Myron
authors: M
authors: Gross
authors: Kathy
authors: K
authors: Helzlsouer
authors: Eric J
authors: EJ
authors: Jacobs
authors: Andrea
authors: A
authors: LaCroix
authors: Wei
authors: W
authors: Zheng
authors: Demetrius
authors: D
authors: Albanes
authors: William
authors: W
authors: Bamlet
authors: Christine D
authors: CD
authors: Berg
authors: Franco
authors: F
authors: Berrino
authors: Sheila
authors: S
authors: Bingham
authors: Julie E
authors: JE
authors: Buring
authors: Paige M
authors: PM
authors: Bracci
authors: Federico
authors: F
authors: Canzian
authors: Françoise
authors: F
authors: Clavel-Chapelon
authors: Sandra
authors: S
authors: Clipp
authors: Michelle
authors: M
authors: Cotterchio
authors: Mariza
authors: M
authors: de Andrade
authors: Eric J
authors: EJ
authors: Duell
authors: John W
authors: JW
authors: Fox
authors: Steven
authors: S
authors: Gallinger
authors: J Michael
authors: JM
authors: Gaziano
authors: Edward L
authors: EL
authors: Giovannucci
authors: Michael
authors: M
authors: Goggins
authors: Carlos A
authors: CA
authors: González
authors: Göran
authors: G
authors: Hallmans
authors: Susan E
authors: SE
authors: Hankinson
authors: Manal
authors: M
authors: Hassan
authors: Elizabeth A
authors: EA
authors: Holly
authors: David J
authors: DJ
authors: Hunter
authors: Amy
authors: A
authors: Hutchinson
authors: Rebecca
authors: R
authors: Jackson
authors: Kevin B
authors: KB
authors: Jacobs
authors: Mazda
authors: M
authors: Jenab
authors: Rudolf
authors: R
authors: Kaaks
authors: Alison P
authors: AP
authors: Klein
authors: Charles
authors: C
authors: Kooperberg
authors: Robert C
authors: RC
authors: Kurtz
authors: Donghui
authors: D
authors: Li
authors: Shannon M
authors: SM
authors: Lynch
authors: Margaret
authors: M
authors: Mandelson
authors: Robert R
authors: RR
authors: McWilliams
authors: Julie B
authors: JB
authors: Mendelsohn
authors: Dominique S
authors: DS
authors: Michaud
authors: Sara H
authors: SH
authors: Olson
authors: Kim
authors: K
authors: Overvad
authors: Alpa V
authors: AV
authors: Patel
authors: Petra H M
authors: PH
authors: Peeters
authors: Aleksandar
authors: A
authors: Rajkovic
authors: Elio
authors: E
authors: Riboli
authors: Harvey A
authors: HA
authors: Risch
authors: Xiao-Ou
authors: XO
authors: Shu
authors: Gilles
authors: G
authors: Thomas
authors: Geoffrey S
authors: GS
authors: Tobias
authors: Dimitrios
authors: D
authors: Trichopoulos
authors: Stephen K
authors: SK
authors: Van Den Eeden
authors: Jarmo
authors: J
authors: Virtamo
authors: Jean
authors: J
authors: Wactawski-Wende
authors: Brian M
authors: BM
authors: Wolpin
authors: Herbert
authors: H
authors: Yu
authors: Kai
authors: K
authors: Yu
authors: Anne
authors: A
authors: Zeleniuch-Jacquotte
authors: Stephen J
authors: SJ
authors: Chanock
authors: Patricia
authors: P
authors: Hartge
authors: Robert N
authors: RN
authors: Hoover
mesh_terms: D000017:ABO Blood-Group System / Q000235:genetics*; D000483:Alleles; D016022:Case-Control Studies; D002899:Chromosomes, Human, Pair 9; D015331:Cohort Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D055106:Genome-Wide Association Study; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D007438:Introns; D015810:Linkage Disequilibrium; D016015:Logistic Models; D008297:Male; D016017:Odds Ratio; D010190:Pancreatic Neoplasms / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011446:Prospective Studies; D012307:Risk Factors; D014481:United States
chemical_list: D000017:ABO Blood-Group System