title: Haptoglobin: basic and clinical aspects.
abstract: Haptoglobin is an abundant hemoglobin-binding protein present in the plasma. The function of haptoglobin is primarily to determine the fate of hemoglobin released from red blood cells after either intravascular or extravascular hemolysis. There are two common alleles at the Hp genetic locus denoted 1 and 2. There are functional differences between the Hp 1 and Hp 2 protein products in protecting against hemoglobin-driven oxidative stress that appear to have important clinical significance. In particular, individuals with the Hp 2-2 genotype and diabetes mellitus appear to be at significantly higher risk of microvascular and macrovascular complications. A pharmacogenomic strategy of administering high dose antioxidants specifically to Hp 2-2 DM individuals may be clinically effective.
authors: Department of Anatomy and Cell Biology, Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel. alevy@tx.technion.ac.il
authors: Andrew P
authors: AP
authors: Levy
authors: Rabea
authors: R
authors: Asleh
authors: Shany
authors: S
authors: Blum
authors: Nina S
authors: NS
authors: Levy
authors: Rachel
authors: R
authors: Miller-Lotan
authors: Shiri
authors: S
authors: Kalet-Litman
authors: Yefim
authors: Y
authors: Anbinder
authors: Orit
authors: O
authors: Lache
authors: Farid M
authors: FM
authors: Nakhoul
authors: Roy
authors: R
authors: Asaf
authors: Dan
authors: D
authors: Farbstein
authors: Mordechai
authors: M
authors: Pollak
authors: Yitzhak Z
authors: YZ
authors: Soloveichik
authors: Merav
authors: M
authors: Strauss
authors: Jonia
authors: J
authors: Alshiek
authors: Alina
authors: A
authors: Livshits
authors: Avery
authors: A
authors: Schwartz
authors: Hoda
authors: H
authors: Awad
authors: Kheir
authors: K
authors: Jad
authors: Hagit
authors: H
authors: Goldenstein
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use; D003920:Diabetes Mellitus / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006242:Haptoglobins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D018384:Oxidative Stress / Q000235:genetics / Q000502:physiology; D014652:Vascular Diseases / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism
chemical_list: D000975:Antioxidants; D006242:Haptoglobins; D006454:Hemoglobins