Intravenous immunoglobulin-induced, non-eczematous, vesiculobullous eruptions in Stevens-Johnson syndrome.
Intravenous immunoglobulin (IVIG) has emerged as a promising treatment that interrupts the progression of Stevens-Johnson syndrome (SJS). Our patient experienced an uncommon adverse effect, non-eczematous, vesiculobullous eruptions, after treatment with IVIG. These new lesions developed rapidly on the palms while most previous SJS bullous lesions subsided. A skin biopsy of these new lesions showed an intracorneal vesicle, without epidermal necrosis, with inflammatory cell infiltration. IVIG-induced, vesiculobullous eruptions are discussed, along with their possible pathogenesis. With the increasing use of IVIG for treatment of bullous dermatoses, recognition of this rare adverse effect is important for prompt differential diagnosis.
Lin
Wan-Lung
WL
Department of Dermatology, Chang Gung Memorial Hospital, Taipei, Taiwan.
Lin
Wen-Chi
WC
Chang
Ya-Ching
YC
Yang
Li-Cheng
LC
Hung
Shuen-Iu
SI
Hong
Hong-Shang
HS
Chung
Wen-Hung
WH
D001706:Biopsy; D003937:Diagnosis, Differential; D005260:Female; D006229:Hand Dermatoses / Q000139:chemically induced / Q000175:diagnosis; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000009:adverse effects* / Q000627:therapeutic use; D007155:Immunologic Factors / Q000009:adverse effects / Q000627:therapeutic use; D008875:Middle Aged; D012872:Skin Diseases, Vesiculobullous / Q000139:chemically induced* / Q000175:diagnosis; D013262:Stevens-Johnson Syndrome / Q000188:drug therapy*
D016756:Immunoglobulins, Intravenous; D007155:Immunologic Factors