Rapidly recurring folliculostellate cell tumor of the adenohypophysis with the morphology of a spindle cell oncocytoma: case report with electron microscopic studies.
We report a rapidly recurring folliculostellate cell tumor of the adenohypophysis in a 63-year-old woman. Morphologically the tumor had the typical appearance of a spindle cell oncocytoma of the adenohypophysis. It recurred within 5 months of selective transsphenoidal resection, requiring a second transsphenoidal operation followed by radiation therapy. The spindle cell oncocytoma (SCO) of the adenohypophysis is a relatively recently described entity and a new addition to the fourth edition of the WHO Classification of Tumors of the Central Nervous System. In our case, the ultrastructural features were significantly different from those so far described in SCO, in that tumor cells formed a network of structures indistinguishable from pituitary follicles. In addition, a minority of tumor cells exhibited endocrine differentiation.
Coiré
C I
CI
Departments of Laboratory Medicine, Trillium Health Center, Mississauga, Canada. ccoire@thc.on.ca
Horvath
E
E
Smyth
H S
HS
Kovacs
K
K
D018249:Adenoma, Oxyphilic / Q000503:physiopathology / Q000648:ultrastructure*; D014408:Biomarkers, Tumor / Q000032:analysis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D046529:Microscopy, Electron, Transmission; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000503:physiopathology / Q000648:ultrastructure*
D014408:Biomarkers, Tumor