title: Wnt/Planar cell polarity signaling: a new paradigm for cancer therapy.
abstract: The evolutionarily conserved and developmentally important Wnt signaling pathway has traditionally been regarded as a critical player in tumorigenesis through the canonical Wnt/beta-catenin cascade. Nevertheless, accumulating evidence based on recent research has revealed the previously unacknowledged role of noncanonical Wnt/planar cell polarity (PCP) signaling in cancer progression, invasion and metastasis, and angiogenesis. This review describes the PCP signaling pathway and its ever-expanding components and modulators, highlights the most recent studies that provide insight into the link between PCP signaling and cancer, and, finally, proposes a model by which PCP signaling may promote cancer development. This review underscores the emerging theme that deregulated PCP signaling contributes to tumorigenesis, providing new potential targets for cancer therapy.
authors: Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA. yingqunw@mail.med.upenn.edu
authors: Yingqun
authors: Y
authors: Wang
mesh_terms: D000818:Animals; D016764:Cell Polarity; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000188:drug therapy*; D015398:Signal Transduction; D051153:Wnt Proteins / Q000378:metabolism*
chemical_list: D051153:Wnt Proteins