title: A cross-sectional observation of effect of exposure to N-methyl-2-pyrrolidone (NMP) on workers' health.
abstract: This study was aimed at clarifying the effect of exposure to N-methyl-2-pyrrolidone (NMP) on workers' health. Fifteen male NMP-exposed workers and 15 referent male workers were recruited for this study. Exposure concentrations were assessed by determining NMP in the breathing zones and urinary NMP. Clinical examinations, motor and sensory nerve conduction velocities in the dominant arm, and neurobehavioral tests were carried out. The subjects were asked to complete self-administered questionnaires for subjective symptoms and psychological assessment. The mean NMP exposure concentrations ranged from 0.14 to 0.26 ppm, and urinary NMP levels at the end of each workday ranged from 0.17 to 0.22 mg/l, throughout the work week. In terms of clinical data, motor and sensory nerve conduction velocities, neurobehavioral tests, and subjective symptom assessments, there were no differences and no dose-dependent changes in either the means or the prevalence of abnormal findings between NMP-exposed and referent workers.
authors: Department of Preventive Medicine and Public Health, Shinshu University School of Medicine, Nagano 390-8621, Japan.
authors: Shigeru
authors: S
authors: Nishimura
authors: Hirohiko
authors: H
authors: Yasui
authors: Hiroyuki
authors: H
authors: Miyauchi
authors: Yuriko
authors: Y
authors: Kikuchi
authors: Nami
authors: N
authors: Kondo
authors: Toru
authors: T
authors: Takebayashi
authors: Shigeru
authors: S
authors: Tanaka
authors: Yuko
authors: Y
authors: Mikoshiba
authors: Kazuyuki
authors: K
authors: Omae
authors: Tetsuo
authors: T
authors: Nomiyama
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure; D011760:Pyrrolidinones / Q000009:adverse effects* / Q000302:isolation & purification / Q000652:urine; D011795:Surveys and Questionnaires; D013723:Teratogens / Q000302:isolation & purification
chemical_list: D011760:Pyrrolidinones; D013723:Teratogens; C038678:N-methylpyrrolidone