title: Surgical treatment of juvenile nasopharyngeal angiofibroma with intracranial extension. Clinical article.
abstract: OBJECTIVE
  The purpose of this study was to describe the surgical treatment and outcomes of patients with intracranial extension of juvenile nasopharyngeal angiofibroma (JNA).
  
  
  METHODS
  Twenty-one patients who underwent operations for JNAs between 1994 and 2008 were enrolled in the study. Seven patients (33%) had intracranial tumor extension. The middle cranial fossa and cavernous sinus were involved in 4 patients who underwent operations via the combined infratemporal fossa-midfacial degloving approach. The anterior skull base was involved in 3 patients who underwent the subcranialmidfacial degloving approach.
  
  
  RESULTS
  Complete tumor removal was achieved in all patients. Postoperative complications included 1 case of soft-tissue infection. None of the patients had tumor recurrence after a mean follow-up of 42 months (range 29-85 months). No adjuvant therapy was required in any patient.
  
  
  CONCLUSIONS
  Combined approaches can be used effectively for treatment of JNAs with intracranial extension without the need for adjuvant therapy.
authors: Skull Base Surgery Service, Tel-Aviv University, Tel-Aviv, Israel.
authors: Nevo
authors: N
authors: Margalit
authors: Oshri
authors: O
authors: Wasserzug
authors: Ari
authors: A
authors: De-Row
authors: Avraham
authors: A
authors: Abergel
authors: Dan M
authors: DM
authors: Fliss
authors: Ziv
authors: Z
authors: Gil
mesh_terms: D000293:Adolescent; D000328:Adult; D018322:Angiofibroma / Q000473:pathology* / Q000601:surgery*; D002426:Cavernous Sinus; D015331:Cohort Studies; D006801:Humans; D008297:Male; D009303:Nasopharyngeal Neoplasms / Q000473:pathology* / Q000601:surgery*; D010256:Paranasal Sinuses; D012189:Retrospective Studies; D019291:Skull Base; D016896:Treatment Outcome; D055815:Young Adult