title: Allogeneic hematopoietic cell transplantation for myelodysplastic syndrome: prognostic significance of pre-transplant IPSS score and comorbidity.
abstract: We analyzed the clinical significance of pre-transplant International Prognostic Scoring System (IPSS) score and comorbidity in 68 patients who underwent allogeneic hematopoietic cell transplantation (HCT) for myelodysplastic syndrome (MDS) (n=48) or acute myeloid leukemia evolved from MDS (n=20) between December 1995 and January 2008 in a single institute. During a median follow-up period of 41.0 months (range, 3.2-132.0 months), 27 patients died, and 7 relapsed. The 5-year probabilities of overall survival (OS) and event-free survival (EFS) were 60.0 and 57.4%, respectively, and the 5-year cumulative incidences of non-relapse mortality (CINRM) and relapse were 32.7 and 9.9%, respectively. OS, EFS, and CINRM were significantly different according to pre-transplant IPSS score and presence of pre-transplant comorbidity, which were independent risk factors along with Karnofsky performance score in multivariate analyses. In conclusion, pre-transplant IPSS score and comorbidity may stratify the risk of post transplant outcomes in MDS.
authors: Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. jhlee3@amc.seoul.kr
authors: J-H
authors: JH
authors: Lee
authors: J-H
authors: JH
authors: Lee
authors: S-N
authors: SN
authors: Lim
authors: D-Y
authors: DY
authors: Kim
authors: S H
authors: SH
authors: Kim
authors: Y-S
authors: YS
authors: Lee
authors: Y-A
authors: YA
authors: Kang
authors: S-I
authors: SI
authors: Kang
authors: M J
authors: MJ
authors: Jeon
authors: M
authors: M
authors: Seol
authors: E-J
authors: EJ
authors: Seo
authors: H S
authors: HS
authors: Chi
authors: C J
authors: CJ
authors: Park
authors: S
authors: S
authors: Jang
authors: S-C
authors: SC
authors: Yun
authors: K-H
authors: KH
authors: Lee
mesh_terms: D000328:Adult; D015897:Comorbidity; D018572:Disease-Free Survival; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000453:epidemiology / Q000628:therapy*; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate; D014184:Transplantation, Homologous; D016896:Treatment Outcome; D055815:Young Adult