New nonlinear multivariable model shows the relationship between central corneal thickness and HRTII topographic parameters in glaucoma patients.
OBJECTIVE
In this paper a new nonlinear multivariable regression method is presented in order to investigate the relationship between the central corneal thickness (CCT) and the Heidelberg Retina Tomograph (HRTII) optic nerve head (ONH) topographic measurements, in patients with established glaucoma.


METHODS
Forty nine eyes of 49 patients with glaucoma were included in this study. Inclusion criteria were patients with (a) HRT II ONH imaging of good quality (SD < 30 mum), (b) reliable Humphrey visual field tests (30-2 program), and (c) bilateral CCT measurements with ultrasonic contact pachymetry. Patients were classified as glaucomatous based on visual field and/or ONH damage. The relationship between CCT and topographic parameters was analyzed by using the new nonlinear multivariable regression model.


RESULTS
In the entire group, CCT was 549.78 +/- 33.08 mum (range: 484-636 mum); intraocular pressure (IOP) was 16.4 +/- 2.67 mmHg (range: 11-23 mmHg); MD was -3.80 +/- 4.97 dB (range: 4.04 - [-20.4] dB); refraction was -0.78 +/- 2.46 D (range: -6.0 D to +3.0 D). The new nonlinear multivariable regression model we used indicated that CCT was significantly related (R(2) = 0.227, p < 0.01) with rim volume nasally and type of diagnosis.


CONCLUSIONS
By using the new nonlinear multivariable regression model, in patients with established glaucoma, our data showed that there is a statistically significant correlation between CCT and HRTII ONH structural measurements, in glaucoma patients.
Kourkoutas
Dimitrios
D
Department of Ophthalmology, Medical School, 417 Hellenic Army Shared Fund Hospital,Athens University, Athens, Greece. d_kourkoutas@hotmail.com
Georgopoulos
Gerasimos
G
Maragos
Antonios
A
Apostolakis
Ioannis
I
Tsekouras
George
G
Karanasiou
Irene S
IS
Papaconstantinou
Dimitrios
D
Iliakis
Evaggelos
E
Moschos
Michael
M