[Study on the inhibitory effect of Reduqing Oral Liquid on respiratory syncytial virus in vitro].
OBJECTIVE
To explore the antiviral effect of Reduqing Oral Liquid on respiratory syncytial virus (RSV).


METHODS
The anti-RSV effect of Reduqing Oral Liquid in Hep-2 cell culture was investigated by the cytopathic effect (CPE) inhibition assay and MTT assay, with ribavirin as the positive control drug.


RESULTS
Reduqing Oral Liquid was effectively antiviral agent for RSV in a concentration-dependent manner in vitro. The median toxic concentration (TC50) was 9182.4 mg/L, the median effective concentration (EC50) was 559.8 mg/L and the treatment index (TI) was 16.4.


CONCLUSIONS
Reduqing Oral Liquid has obvious inhibitory effect on RSV in vitro.
Huang
Sheng-Hai
SH
Department of Microbiology, Anhui Medical University, Hefei 230032, China. shhuang@ahmu.edu.cn
Feng
Xiao-Liang
XL
Liu
Wei
W
D000998:Antiviral Agents / Q000008:administration & dosage / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D010946:Plants, Medicinal / Q000737:chemistry*; D012136:Respiratory Syncytial Viruses / Q000187:drug effects*; D012254:Ribavirin / Q000008:administration & dosage / Q000494:pharmacology; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D012254:Ribavirin