Highlights of recent research on the synthesis of ketolide antibiotics.
Intense recent effort towards the development of new drug candidates in the macrolide arena has resulted in the emergence of a number of novel chemical entities; two of these, ABT-773 and HMR-3647, are currently at the advanced clinical trial stage. This review covers the various approaches described in the literature specifically for the synthesis of the ketolide class of compounds.
Resek
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Abbott Laboratories, Specialty Products Division, Department 54P, North Chicago, IL 60064, USA.
Wang
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XC
Bhatia
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