Unusual leptomeningeal dissemination in a child with extracranial metastatic alveolar rhabdomyosarcoma.
The authors describe a 6-year-old boy diagnosed with alveolar rhabdomyosarcoma located in the thigh, with distal metastases to lungs, bones, and bone marrow. A very good partial response to first-line chemotherapy was obtained, but the child developed fatal leptomeningeal dissemination immediately after complete resection of the primary tumor. This case demonstrates the rapidity with which leptomeningeal spread of extracranial metastatic alveolar rhabdomyosarcoma can occur and underscores the importance of diagnostic lumbar puncture and brain radiological investigations at diagnosis, even when the tumors are not in the parameningeal location.
Arush
Myriam Weyl Ben
MW
Department of Pediatric Hematology Oncology, Meyer Children's Hospital, Rambam Health Care Campus, Haifa, Israel. m benarush@rambam.health.gov.il
Kollender
Yehuda
Y
Issakov
Josephine
J
Shalom
Rachel Bar
RB
Arieh
Yehudit Ben
YB
Malkin
Leonid
L
Postovsky
Sergey
S
D019046:Bone Marrow Neoplasms / Q000188:drug therapy / Q000556:secondary*; D001932:Brain Neoplasms / Q000188:drug therapy / Q000556:secondary*; D002648:Child; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000556:secondary*; D008279:Magnetic Resonance Imaging; D008297:Male; D008577:Meningeal Neoplasms / Q000188:drug therapy / Q000556:secondary*; D018232:Rhabdomyosarcoma, Alveolar / Q000556:secondary*; D012983:Soft Tissue Neoplasms / Q000473:pathology*; D013848:Thigh