title: Mucosal lesions in a sheep infected with the Border Disease Virus (BDV).
abstract: A 28-week-old sheep was presented at the animal hospital because of chronic emaciation, anemia and slight diarrhea. Due to poor general condition and bad prognosis the animal was euthanized and submitted for postmortem investigation. Multiple erosions and ulcerations were found in the dorsal region of the tongue, the pharynx, the hard palate, in the esophagus and the ruminal pillars. Histologically, these lesions consisted of necrosuppurative inflammation. The animal was tested positive for pestivirus antigen both by immunohistochemical and by virological examination (cell culture, antigen capture ELISA and RT-PCR). A non-cytopathic Border Disease Virus was identified, and sequencing revealed a virus belonging to the BDV-3 cluster. Based on the macroscopical, histological, immunohistological and virological results this case was diagnosed as Border Disease with mucosal lesions. This is the first report of such a case in Switzerland.
authors: Institute of Veterinary Pathology, University of Zürich, Winterthurerstrasse 268, Zurich CH-8057, Switzerland. hilbe@vetpath.uzh.ch
authors: M
authors: M
authors: Hilbe
authors: U
authors: U
authors: Camenisch
authors: U
authors: U
authors: Braun
authors: E
authors: E
authors: Peterhans
authors: H
authors: H
authors: Stalder
authors: K
authors: K
authors: Zlinszky
authors: F
authors: F
authors: Ehrensperger
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001882:Border Disease / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology*; D018083:Border disease virus / Q000145:classification / Q000276:immunology / Q000302:isolation & purification*; D017809:Fatal Outcome; D005260:Female; D007150:Immunohistochemistry / Q000662:veterinary; D009092:Mucous Membrane / Q000473:pathology* / Q000821:virology*; D012756:Sheep; D013557:Switzerland / Q000453:epidemiology