Diketopiperazine alkaloids from a deep ocean sediment derived fungus Penicillium sp.
Five new diketopiperazine alkaloids, brevicompanines D-H (3-7), together with two known analogs, allo-brevicompanine B (1) and fructigenine B (2), were isolated from a deep ocean sediment derived fungus Penicillium sp. Their structures were established by spectroscopic methods including 2D NMR and chiral HPLC analysis. Compounds 4 and 7 inhibited lipopolysaccharide (LPS)-induced nitric oxide production in BV2 microglial cells.
Du
Lin
L
Key Laboratory of Marine Drugs, Chinese Ministry of Education, Institute of Marine Drugs and Food, Ocean University of China, Qingdao, P.R. China.
Yang
Xinying
X
Zhu
Tianjiao
T
Wang
Fengping
F
Xiao
Xiang
X
Park
Hyun
H
Gu
Qianqun
Q
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D054659:Diketopiperazines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000037:antagonists & inhibitors / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy / Q000592:standards; D051379:Mice; D017628:Microglia / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D009569:Nitric Oxide / Q000096:biosynthesis; D010407:Penicillium / Q000737:chemistry*; D012015:Reference Standards
D054659:Diketopiperazines; D008070:Lipopolysaccharides; D009569:Nitric Oxide