title: No genetic association between the SLC1A2 gene and Japanese patients with schizophrenia.
abstract: Glutamatergic dysfunction may be a pathophysiological feature in the brains of schizophrenic patients. In addition to glutamate receptors, excitatory amino acid transporters (EAATs) have received much attention because they directly affect glutamatergic neurotransmission by excluding excessive glutamate from the synaptic cleft. Among these, EAAT2 (also known as solute carrier family 1, member 2; SLC1A2) has been widely studied in schizophrenia pathophysiology. During the last decade, we reported significant decreases in EAAT2 mRNA expression in the prefrontal cortex and parahippocampal gyrus in postmortem schizophrenic brains. Previously, a haplotype association between SLC1A2 and Japanese patients with schizophrenia was reported. In this study, we reinvestigated the association between SLC1A2 and schizophrenia by performing a case-control association study with twice as many subjects (401 cases and 407 controls) as compared to a previous study, and especially focused on the region where a previous association with schizophrenia had been shown. Our current results failed to show any significant association with schizophrenia in individual single nucleotide polymorphisms (SNPs), two- and three-SNP-based haplotypes, or with possible pairwise haplotype analysis. SCL1A2 appears not to be a genetic risk factor for schizophrenia.
authors: Juntendo University School of Medicine, Tokyo, Japan.
authors: Yasuhito
authors: Y
authors: Nagai
authors: Tohru
authors: T
authors: Ohnuma
authors: Jun
authors: J
authors: Karibe
authors: Nobuto
authors: N
authors: Shibata
authors: Hitoshi
authors: H
authors: Maeshima
authors: Hajime
authors: H
authors: Baba
authors: Tokiko
authors: T
authors: Hatano
authors: Ryo
authors: R
authors: Hanzawa
authors: Heii
authors: H
authors: Arai
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D027342:Excitatory Amino Acid Transporter 2; D005260:Female; D020022:Genetic Predisposition to Disease; D050491:Glutamate Plasma Membrane Transport Proteins / Q000235:genetics*; D006801:Humans; D007564:Japan; D008297:Male; D012559:Schizophrenia / Q000235:genetics*
chemical_list: D027342:Excitatory Amino Acid Transporter 2; D050491:Glutamate Plasma Membrane Transport Proteins; C493397:SLC1A2 protein, human