title: Carotid and femoral arterial wall changes and the prevalence of clinical cardiovascular disease.
abstract: The Cyprus Study is a prospective cohort study of cardiovascular disease (CVD). Its aim is to determine the relationship of intima-media thickness (IMT) of the common carotid (IMTcc), maximum thickness of IMT in the carotid bifurcation (IMTmax), number of carotid and femoral bifurcations with plaque and total plaque thickness (TPT) (sum of the maximum plaque measurements taken from the four bifurcations scanned) with the prevalence of clinical CVD. A total of 767 individuals (46% male) over the age of 40 years were recruited from a mountain village and a town outside the capital Nicosia. In addition to clinical examination, carotid and common femoral bifurcations were scanned with ultrasound. After controlling for conventional risk factors, there was little evidence of an association of IMTcc with CVD prevalence. However, IMTmax and TPT were associated with 2.9-fold (1.22 to 7.07) and 6.87-fold (2.42 to 19.43) increased odds of CVD prevalence, respectively. In conclusion, the TPT and number of bifurcations with plaque are more strongly associated with the prevalence of CVD. These findings warrant investigation in prospective studies to document associations with incident CVD events.
authors: Vascular Noninvasive Screening and Diagnostic Centre, London, UK. maurabgriffin@googlemail.com
authors: Maura
authors: M
authors: Griffin
authors: Andrew
authors: A
authors: Nicolaides
authors: Theodosis
authors: T
authors: Tyllis
authors: Niki
authors: N
authors: Georgiou
authors: Richard M
authors: RM
authors: Martin
authors: Dawn
authors: D
authors: Bond
authors: Andrie
authors: A
authors: Panayiotou
authors: Chrysa
authors: C
authors: Tziakouri
authors: Caroline J
authors: CJ
authors: Doré
authors: Charris
authors: C
authors: Fessas
mesh_terms: D000368:Aged; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000209:etiology / Q000473:pathology; D002340:Carotid Artery Diseases / Q000150:complications / Q000453:epidemiology* / Q000473:pathology; D017536:Carotid Artery, Common / Q000000981:diagnostic imaging / Q000473:pathology*; D003430:Cross-Sectional Studies; D003535:Cyprus / Q000453:epidemiology; D005260:Female; D005263:Femoral Artery / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D016491:Peripheral Vascular Diseases / Q000150:complications / Q000453:epidemiology* / Q000473:pathology; D011159:Population Surveillance; D011237:Predictive Value of Tests; D015995:Prevalence; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D012720:Severity of Illness Index; D017539:Tunica Intima / Q000473:pathology; D017540:Tunica Media / Q000473:pathology; D018615:Ultrasonography, Doppler, Color; D018616:Ultrasonography, Doppler, Duplex