title: Association of the LRP1 gene and cognitive performance with amnestic mild cognitive impairment in elderly Chinese.
abstract: BACKGROUND
  The genetic region coding for low-density lipoprotein receptor-related protein1 (LRP1) is considered an intriguing susceptibility locus for Alzheimer's disease (AD). Amnestic mild cognitive impairment (aMCI) is characterized by episodic memory impairment and represents the prodromal stage of AD. Our aim in this study is to investigate the relationship between LRP1 genetic variation and aMCI, and the influence of LRP1 on cognitive performance.
  
  
  METHODS
  We performed a case-control association study analyzing five polymorphisms in LRP1 gene by TaqMan Assays-on-Demand SNP Genotyping. All samples were derived from Chinese subjects (109 cases, 104 healthy controls) and assessed using multi-dimension neuropsychological instruments.
  
  
  RESULTS
  We identified haplotypes within the region containing the LRP1 gene. Of these, haplotype TAA (T: rs1800194; A: rs11837145; A: rs10876967) was significantly associated with aMCI, being over-represented in aMCI versus healthy controls. Haplotype TAA was associated with poor performance on episodic memory in all subjects.
  
  
  CONCLUSIONS
  This study confirms the association between genetic variants in LRP1 and aMCI. Moreover, we have identified a relationship between LRP1 genetic variation and specific aspects of neurocognitive function. Our convergent results suggest that LRP1 plays an important role in cognitive function and possibly in the pathogenesis of aMCI.
authors: School of Clinical Medicine, Southeast University, Nanjing, China.
authors: Yong M
authors: YM
authors: Shi
authors: Hong
authors: H
authors: Zhou
authors: Zhi J
authors: ZJ
authors: Zhang
authors: Hui
authors: H
authors: Yu
authors: Feng
authors: F
authors: Bai
authors: Yong G
authors: YG
authors: Yuan
authors: Ling L
authors: LL
authors: Deng
authors: Jian P
authors: JP
authors: Jia
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D000647:Amnesia / Q000175:diagnosis / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D003072:Cognition Disorders / Q000175:diagnosis / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D026503:Low Density Lipoprotein Receptor-Related Protein-1 / Q000235:genetics*; D008297:Male; D009483:Neuropsychological Tests / Q000706:statistics & numerical data*; D010641:Phenotype; D011110:Polymorphism, Genetic / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011594:Psychometrics
chemical_list: D026503:Low Density Lipoprotein Receptor-Related Protein-1