Diels-Alder cycloaddition strategy for kinetic resolution of chiral pyrazolidinones.
A rare example of the application of a catalytic, enantioselective Diels-Alder cycloaddition to affect a kinetic resolution has been developed. Chiral pyrazolidinones are resolved with high selectivity through a process that utilizes a relay of stereochemical information from a permanent chiral center to a fluxional chiral center to enhance the inherent selectivity of the chiral Lewis acid catalyst.
Sibi
Mukund P
MP
Department of Chemistry and Molecular Biology, North Dakota State University, NDSU Department 2735, P.O. Box 6050, Fargo, North Dakota 58108-6050, USA. mukund.sibi@ndsu.edu
Kawashima
Keisuke
K
Stanley
Levi M
LM