Hyaline inclusion myopathy: unmasked by statin therapy.
We report a case of a patient with history of alcohol abuse, treatment for hepatitis C and repeated strenuous physical activity who developed severe muscle pain and weakness during statin therapy. The symptoms persisted after discontinuation of the drug. The diagnosis of myopathy was made clinically and by electromyography. As his symptoms persisted a muscle biopsy was performed which showed inclusions consistent with hyaline inclusions. Hyaline inclusion myopathy is discussed in the context of this case with review of the literature.
Supala-Berger
Agnes
A
asupala@buffalo.edu
Fine
Edward
E
Heffner
Reid
R
Young-McLain
Eufrosina
E
D000437:Alcoholism / Q000150:complications; D004576:Electromyography; D004594:Electrophysiology; D019698:Hepatitis C, Chronic / Q000150:complications; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D006937:Hypercholesterolemia / Q000150:complications / Q000188:drug therapy; D015228:Hypertriglyceridemia / Q000150:complications / Q000188:drug therapy; D007372:Interferons / Q000627:therapeutic use; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D018908:Muscle Weakness / Q000139:chemically induced / Q000503:physiopathology; D018482:Muscle, Skeletal / Q000473:pathology; D018979:Myositis, Inclusion Body / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D019821:Simvastatin / Q000009:adverse effects* / Q000627:therapeutic use
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D007372:Interferons; D019821:Simvastatin