title: [Prevalence of anti-thyroid peroxidase and anti-adrenal 21-hidroxylase in type 1 diabetes patients].
abstract: There is still no consensus about the best strategy to screen Addison's disease (AD) in type 1 diabetes mellitus (T1DM) patients.
  
  
  OBJECTIVE
  The aim of this study was to determine the frequency of anti-21-hydroxilase (anti-21OH) in a multiethnic T1DM population and investigate if its presence is associated with any adrenal dysfunction or thyroid autoimmunity.
  
  
  METHODS
  Forty individuals underwent an interview and blood was drawn for anti-thyroperoxidase (anti-TPO), anti-21OH, TSH, free T4 and cortisol measurement.
  
  
  RESULTS
  Anti-21OH was found in 7.5% (n = 3), none with adrenal dysfunction. This antibody was not exclusively seen in patients with anti-TPO (+). Anti-TPO was positive in 25% and associated with higher TSH levels (p = 0.034) and older age (p = 0.009).
  
  
  CONCLUSIONS
  Although the frequency of anti-TPO in this sample was similar to previous studies, a higher prevalence of anti-21-OH was found. However, no coexisting adrenal dysfunction was detected, which does not support universal screening for AD in this group.
authors: Serviço de Endocrinologia, Hospital Universitário Clementino Fraga Filho (HUCFF), Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brasil.
authors: Reinaldo Cavalcante
authors: RC
authors: Nunes
authors: Mirella Hansen de
authors: MH
authors: Almeida
authors: Melanie
authors: M
authors: Rodacki
authors: Rosângela Aparecida
authors: RA
authors: Noé
authors: Maria Rocio
authors: MR
authors: Bencke
authors: José Egídio Paulo de
authors: JE
authors: Oliveira
authors: Mario
authors: M
authors: Vaisman
mesh_terms: D000224:Addison Disease / Q000201:enzymology / Q000276:immunology; D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000201:enzymology* / Q000276:immunology; D005260:Female; D006801:Humans; D007453:Iodide Peroxidase / Q000276:immunology*; D008297:Male; D018709:Statistics, Nonparametric; D013255:Steroid 21-Hydroxylase / Q000276:immunology*; D013967:Thyroiditis, Autoimmune / Q000201:enzymology / Q000276:immunology; D013972:Thyrotropin / Q000097:blood
chemical_list: D001323:Autoantibodies; D015415:Biomarkers; D013972:Thyrotropin; D007453:Iodide Peroxidase; D013255:Steroid 21-Hydroxylase