title: Enhanced complement activation is part of the unfavourable cardiovascular risk profile in South Asians.
abstract: South Asian immigrants in western societies exhibit a high burden of diabetes and subsequent vascular complications. Diabetic vascular complications are associated with vascular inflammation. We hypothesize that enhanced complement activation is involved. Therefore, levels of complement C3 and SC5b-9 - the soluble end product of complement activation - in a group of 200 South Asians were compared with an age- and sex-matched control group of native Caucasians. In addition, the association between complement levels and albuminuria, an indicator of renal damage and a cardiovascular risk marker, was assessed in the diabetic South Asian group. Compared with native Caucasians, South Asians had significantly higher levels of both serum C3 and plasma SC5b-9, even when only non-diabetic South Asians were considered. Diabetic South Asians had significantly higher C3 levels compared with non-diabetic South Asians. In diabetic South Asians, higher levels of SC5b-9 were associated with an increased prevalence of albuminuria (odds ratio 5.4, 95% confidence interval 1.8-15.8). These results suggest that enhanced complement activation is part of the unfavourable cardiovascular risk profile in South Asians.
authors: Leiden University Medical Center, Department of Nephrology, Leiden, the Netherlands. m.a.siezenga@lumc.nl
authors: M A
authors: MA
authors: Siezenga
authors: P K
authors: PK
authors: Chandie Shaw
authors: R N
authors: RN
authors: van der Geest
authors: T E
authors: TE
authors: Mollnes
authors: M R
authors: MR
authors: Daha
authors: T J
authors: TJ
authors: Rabelink
authors: S P
authors: SP
authors: Berger
mesh_terms: D000328:Adult; D000368:Aged; D000419:Albuminuria / Q000097:blood / Q000276:immunology; D001210:Asia, Southeastern / Q000208:ethnology; D044466:Asian People; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000276:immunology*; D016022:Case-Control Studies; D003167:Complement Activation; D003176:Complement C3 / Q000276:immunology*; D015938:Complement Membrane Attack Complex / Q000032:analysis; D003924:Diabetes Mellitus, Type 2 / Q000276:immunology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009426:Netherlands; D012306:Risk; D018709:Statistics, Nonparametric
chemical_list: D015415:Biomarkers; D003176:Complement C3; D015938:Complement Membrane Attack Complex; C047610:SC5b-9 protein complex