Senescence and p130/Rbl2: a new beginning to the end.
Senescence is the process of cellular aging dependent on the normal physiological functions of non-immortalized cells. With increasing data being uncovered in this field, the complex molecular web regulating senescence is gradually being unraveled. Recent studies have suggested two main phases of senescence, the triggering of senescence and the maintenance of senescence. Each has been supported by data implying precise roles for DNA methyltransferases, reactive oxygen species and other factors. We will first summarize the data supporting these claims and then highlight the specific role that we hypothesize that p130/Rbl2 plays in the modulation of the senescence process.
Fiorentino
Francesco P
FP
Section of Medical Oncology, Department of Oncology, Regional Reference Center for the Biomolecular Characterization and Genetic Screening of Hereditary Tumors, Università di Palermo, Via del Vespro 127, 90127, Palermo, Italy.
Symonds
Catherine E
CE
Macaluso
Marcella
M
Giordano
Antonio
A
D018797:Cell Cycle Proteins / Q000502:physiology; D016922:Cellular Senescence / Q000502:physiology*; D006801:Humans; D050717:Retinoblastoma-Like Protein p130 / Q000502:physiology*; D016615:Telomere / Q000502:physiology*
D018797:Cell Cycle Proteins; C493837:RBL2 protein, human; D050717:Retinoblastoma-Like Protein p130