[Correlations of chemokine receptor CCR1 expression with metastasis of lymph nodes in colorectal carcinoma tissues].
OBJECTIVE
To investigate the expression of chemokine receptor CCR1 in the human colorectal carcinoma and its correlation with metastasis of lymph nodes.


METHODS
By immunohistochemistry, the expression of CCR1 was studied in the colorectal carcinoma of 83 cases and 15 normal cases as control subjects.


RESULTS
The positive expression rates of CCR1 in the colorectal carcinoma tissues with deep invasion, poor differentiation, metastasis and higher Dukes' stage were significantly higher than those with superficial invasion (P<0.05), well or moderate differentiation (P<0.05), non-metastasis (P<0.01) and lower Dukes' stage (P<0.05). The LMVD was higher in colorectal carcinoma tissues with positive CCR1 staining than those with negative CCR1 staining (P<0.01). But the MVD had no significantly difference in positive CCR1 staining tissues and negative CCR1 staining tissues.


CONCLUSIONS
The expression of chemokine receptor CCR1 is higher in colorectal carcinoma than normal tissues, and it may correlate with lymph node metastasis.
Ma
Jin-an
JA
Department of Oncology, Second Xiangya Hospital, Central South University, Changsha 410011, China. majinancs@hotmail.com
Qiu
Zhen-hua
ZH
Pei
Hai-ping
HP
D000328:Adult; D000368:Aged; D015179:Colorectal Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008198:Lymph Nodes / Q000378:metabolism / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D054389:Receptors, CCR1 / Q000235:genetics* / Q000378:metabolism
C515300:CCR1 protein, human; D054389:Receptors, CCR1