[Efficacy of meloxicam in juvenile polyposis syndrome. A case report].
The Authors present a case of a 11 year-old patient with a history of Juvenile Polyposis Syndrome (JPS), a condition characterized by the occurrence of multiple hamartomatous polyps in the gastrointestinal tract. Patients with JPS are traditionally treated by repeated endoscopic polypectomies and elective surgery. Recent studies reported up-regulation of cyclo-ossigenase 2 (COX-2) in colorectal polyps. Specific COX-2 inhibitors have been withdrown from the market for tromboembolic side effects. However efficacy and safety of preferential selective COX-2 inhibitor has been reported as antiinflammatory drugs also in children. In this patient meloxicam treatment, a preferential selective COX-2 inhibitor, leaded to a significant reduction in the number of colorectal polyps during 3 years follow up.
Lorusso
Monica
M
Dipartimento di Pediatria, Università di Firenze, Ospedale Meyer, Firenze.
Mangiantini
Francesca
F
Pozzi
Elena
E
Nucci
Andrea
A
Bronzini
Francesca
F
Bevilacqua
Silvia
S
Lionetti
Paolo
P
D011125:Adenomatous Polyposis Coli / Q000175:diagnosis; D002648:Child; D003111:Colonic Polyps / Q000175:diagnosis* / Q000188:drug therapy*; D016861:Cyclooxygenase Inhibitors / Q000627:therapeutic use*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D000077239:Meloxicam; D013577:Syndrome; D013843:Thiazines / Q000627:therapeutic use*; D013844:Thiazoles / Q000627:therapeutic use*; D016896:Treatment Outcome
D016861:Cyclooxygenase Inhibitors; D013843:Thiazines; D013844:Thiazoles; D000077239:Meloxicam