title: A comparison of 24 h urinary deoxynivalenol with recent v. average cereal consumption for UK adults.
abstract: Deoxynivalenol (DON) is a toxic fungal metabolite found on wheat, maize and barley. We previously reported a significant association between the amount of DON in a single 24 h urine sample and the average cereal intake over 7 d for 300 UK adults. In this more detailed analysis of the data, food diary information (n 255) for the day of urine collection (model I), the previous 24 h period (model II) and the day of urine collection plus the previous 24 h combined (model III) were further examined to assess whether the recent intake of cereal correlated more strongly with urinary DON, compared with the longer-term assessment of usual cereal intake from 7 d food diaries (model IV). DON was detected in 254/255 (99.6 %) urine samples (mean 12.0 microg/d; range not detected-66 microg/d). For all the models, total cereal intake was positively associated with urinary DON (P < 0.001) in each model. The goodness of fit (adjusted R2 value) was used to assess how well each model explained the variation in urinary DON. Model I provided a better goodness of fit (adjusted R2 0.22) than model IV (adjusted R2 0.19), whereas model III provided the best fit (adjusted R2 0.27). These data suggest that the inter-individual variation in urinary DON was somewhat better explained by recent cereal intake compared with usual cereal intake assessed over 7 d.
authors: Molecular Epidemiology Unit, Centre for Epidemiology and Biostatistics, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds, UK. p.c.turner@leeds.ac.uk
authors: Paul C
authors: PC
authors: Turner
authors: Elizabeth F
authors: EF
authors: Taylor
authors: Kay L M
authors: KL
authors: White
authors: Janet E
authors: JE
authors: Cade
authors: Christopher P
authors: CP
authors: Wild
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000652:urine; D015930:Diet Records; D004034:Diet Surveys; D002523:Edible Grain; D004784:Environmental Monitoring / Q000379:methods; D005247:Feeding Behavior; D005260:Female; D005506:Food Contamination / Q000032:analysis*; D006801:Humans; D008297:Male; D014255:Trichothecenes / Q000652:urine*
chemical_list: D015415:Biomarkers; D014255:Trichothecenes; C007262:deoxynivalenol