T-bet-/- RAG2-/- ulcerative colitis: the role of T-bet as a peacekeeper of host-commensal relationships.
Inflammatory bowel disease is a disease that reflects a disequilibrium in host-commensal homeostasis. T-bet-/-xRAG2-/- deficient mice develop a spontaneous juvenile ulcerative colitis resulting from a pro-inflammatory response to the commensal microbiota that is dendritic cell and TNF-alpha driven [schematized in Fig. 1]. The TRUC (T-bet-/- RAG2-/- ulcerative colitis) model is discussed in the broader context of the adaptive and innate immune mechanisms that regulate host-commensal relationships within the intestine.
Garrett
Wendy S
WS
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA. wendy_garrett@dfci.harvard.edu
Glimcher
Laurie H
LH
D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology; D006706:Homeostasis / Q000276:immunology*; D006801:Humans; D055633:Immune System Phenomena / Q000276:immunology; D015212:Inflammatory Bowel Diseases / Q000276:immunology / Q000382:microbiology; D007413:Intestinal Mucosa / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D051379:Mice; D018345:Mice, Knockout; D020825:T-Box Domain Proteins / Q000235:genetics / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D000098815:T-bet Transcription Factor
D004268:DNA-Binding Proteins; C499308:Rag2 protein, mouse; D020825:T-Box Domain Proteins; D000098815:T-bet Transcription Factor