beta-Blockers and hypertension: a therapeutic reappraisal.
beta-Blockers were first described in 1964 and were developed for the treatment of angina pectoris and arrhythmias. Subsequently, indications have broadened to encompass a multitude of clinical scenarios, with hypertension high on the list. Here, the authors consider the extended debate on this topic and discuss the mechanisms of action for traditional and newer beta-blockers and their role in hypertension management.
Panjrath
Gurushar S
GS
Division of Cardiology, St. Luke's-Roosevelt Hospital Center, New York, NY 10019, USA.
Sawhney
Sabrina
S
Messerli
Franz H
FH
D000319:Adrenergic beta-Antagonists / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D000959:Antihypertensive Agents / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use; D004347:Drug Interactions; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*
D000319:Adrenergic beta-Antagonists; D000959:Antihypertensive Agents