[The relevance of neprilysin for systemic homeostasis and its involvement in the pathological processes].
Neprilysin (NEP, CD10, CALLA-common acute lymphoblastic leukaemia antigen, neutral endopeptidase, enkephalinase) is a zinc-dependent metallopeptidase, which is involved in the metabolism of a number of regulatory peptides and plays an important role in turning off peptide signalling at the cell surface. Neprilysin is involved in many physiological and pathological processes in organism. It regulates blood pressure and inflammatory response, takes part in the pathogenesis of Alzheimer disease, influences cellular proliferation and differentiation, as well as neoplastic progression.
Kubiak-Wlekły
Anna
A
Uniwersytet Medyczny w Poznaniu, Katedra i Klinika Nefrologii, Transplantologii i Chorób Wewnetrznych, Pracownia Nefrologii Molekularnej.
Niemir
Zofia I
ZI
D000544:Alzheimer Disease / Q000378:metabolism; D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D018450:Disease Progression; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D009369:Neoplasms / Q000503:physiopathology; D015260:Neprilysin / Q000037:antagonists & inhibitors / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
D015260:Neprilysin