Case report: severe neonatal hyperkalemia due to pseudohypoaldosteronism type 1.
Hyponatremia and hyperkalemia in infancy can represent a variety of renal and genetic disorders with significant long-term health implications. We report a newborn with severe hyperkalemia and hyponatremia from autosomal recessive pseudohypoaldosteronism type 1 requiring aggressive therapy. The evaluation and treatment of children with disorders of mineralocorticoid action are discussed.
Schweiger
Bahareh
B
Department of Pediatrics, Divisions of Pediatric Endocrinology, University of Colorado-Denver, The Children's Hospital, 13123 E. 16th Ave., Aurora, CO 80045, USA.
Moriarty
Margaret W
MW
Cadnapaphornchai
Melissa A
MA
D000450:Aldosterone / Q000097:blood; D002951:Citrates / Q000627:therapeutic use; D019587:Dietary Supplements; D004562:Electrocardiography; D053503:Epithelial Sodium Channels / Q000235:genetics; D005260:Female; D005438:Fludrocortisone / Q000627:therapeutic use; D006801:Humans; D006947:Hyperkalemia / Q000097:blood / Q000175:diagnosis* / Q000235:genetics* / Q000628:therapy; D007231:Infant, Newborn; D008901:Mineralocorticoids / Q000627:therapeutic use; D009154:Mutation; D011188:Potassium / Q000097:blood / Q000652:urine; D011546:Pseudohypoaldosteronism / Q000097:blood / Q000175:diagnosis* / Q000235:genetics* / Q000628:therapy; D012083:Renin / Q000097:blood; D012965:Sodium Chloride / Q000627:therapeutic use; D000077559:Sodium Citrate
D002951:Citrates; D053503:Epithelial Sodium Channels; D008901:Mineralocorticoids; D000077559:Sodium Citrate; D012965:Sodium Chloride; D000450:Aldosterone; D012083:Renin; D011188:Potassium; D005438:Fludrocortisone