Ganoderic acids from Ganoderma lucidum: inhibitory activity of osteoclastic differentiation and structural criteria.
Increased osteoclastic bone resorption plays a central role in the pathogenesis of many bone diseases. Ganoderma lucidum is known for medicinal effects such as anti-inflammatory and anti-bone resorption activities. In this study, we investigated the inhibitory effects of ganoderic acids isolated from G. lucidum on osteoclastic differentiation using RAW264 cells in vitro. A carbonyl in C7 is essential to elicit the inhibition of osteoclast differentiation.
Liu
Jie
J
Department of Forest and Forest Products Sciences, Faculty of Agriculture, Kyushu University, Fukuoka, Japan.
Shiono
Jun
J
Shimizu
Kuniyoshi
K
Kondo
Ryuichiro
R
D000818:Animals; D001862:Bone Resorption / Q000517:prevention & control; D002454:Cell Differentiation / Q000187:drug effects*; D002460:Cell Line; D007810:Lanosterol / Q000031:analogs & derivatives / Q000302:isolation & purification / Q000494:pharmacology*; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D010010:Osteoclasts / Q000166:cytology / Q000187:drug effects*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D020940:Reishi / Q000737:chemistry*
D010936:Plant Extracts; D007810:Lanosterol