Regulation of HIF-1alpha at the transcriptional level.
The hypoxia-inducible factor HIF-1 has been shown to be mandatory for the cellular adaptation to hypoxia. In addition, evidence has been provided that HIF-1 can mediate various stress responses and that it may play an important role under inflammatory conditions even independently of hypoxia. HIF-1 is a heterodimer consisting of an alpha subunit which is subject to tight regulation, and a beta-subunit, also termed ARNT, which appears to be constitutively expressed. In addition to the complex network controlling the cellular content of HIF-1alpha at the level of protein stability, recent evidence showed that HIF-1alpha levels can also be regulated at the mRNA level. In fact, transcriptional regulatory networks seem to be an additional way of controlling HIF-1alpha levels and may open new therapeutic options to modulate HIF-1alpha also under non-hypoxic conditions.
Görlach
Agnes
A
Experimental Pediatric Cardiology, German Heart Center Munich, TU Munich, Germany. goerlach@dhm.mhn.de
D000818:Animals; D051784:Aryl Hydrocarbon Receptor Nuclear Translocator / Q000378:metabolism; D015687:Cell Hypoxia / Q000502:physiology; D005786:Gene Expression Regulation; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000235:genetics* / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism*; D014158:Transcription, Genetic
C497396:ARNT protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D012333:RNA, Messenger; D051784:Aryl Hydrocarbon Receptor Nuclear Translocator