title: Urinary trypsin inhibitor suppresses migration of malignant mesothelioma.
abstract: Urinary trypsin inhibitor (UTI), an inhibitor of urokinase plasminogen activator relevant to proteolytic processing from the inactive into the active form of platelet-derived growth factor-D (PDGF-D) to activate PDGF-betabeta receptor (PDGF-betabetaR), inhibited fetal bovine serum-stimulated migration of human malignant mesothelioma, with the extent varying among the cell types. The more effective inhibition was found in NCIH-2052 and -2452 cells, with the higher expression of PDGF-betabetaR. The results of the present study suggest that UTI suppresses malignant mesothelioma cell migration by neutralizing active dimer of PDGF-D (PDGF-DD)/PDGF-betabetaR-mediated signal transduction.
authors: Department of Physiology, Hyogo College of Medicine, Nishinomiya, Japan.
authors: Takahiro
authors: T
authors: Yaguchi
authors: Masakazu
authors: M
authors: Muramoto
authors: Takashi
authors: T
authors: Nakano
authors: Tomoyuki
authors: T
authors: Nishizaki
mesh_terms: D000077214:Becaplermin; D045744:Cell Line, Tumor; D002633:Chemotaxis; D006023:Glycoproteins / Q000378:metabolism*; D006801:Humans; D008222:Lymphokines / Q000378:metabolism; D008654:Mesothelioma / Q000378:metabolism* / Q000473:pathology; D009361:Neoplasm Invasiveness; D010982:Platelet-Derived Growth Factor / Q000378:metabolism; D055503:Protein Multimerization; D020574:Proto-Oncogene Proteins c-sis; D020797:Receptor, Platelet-Derived Growth Factor beta / Q000378:metabolism; D015398:Signal Transduction; D013997:Time Factors
chemical_list: D006023:Glycoproteins; D008222:Lymphokines; C427493:PDGFD protein, human; D010982:Platelet-Derived Growth Factor; D020574:Proto-Oncogene Proteins c-sis; D000077214:Becaplermin; D020797:Receptor, Platelet-Derived Growth Factor beta; C028665:urinastatin