The road not taken: a path to curing type 1 diabetes?
The past quarter century has seen a rapid increase in our knowledge about the natural history of autoimmune type 1 diabetes. However, we stand unable to achieve our ultimate goal of preventing or reversing this disease. This viewpoint discusses controversies in current management of type 1 diabetes, the challenges in translating promising studies from mouse models of the disease to humans, hurdles faced in designing optimal prevention and intervention studies, and potential strategies to overcome these obstacles.
Haller
Michael J
MJ
Department of Pediatrics, University of Florida, Gainesville, FL 32610, USA. hallemj@peds.ufl.edu
Atkinson
Mark A
MA
Schatz
Desmond A
DA
D000818:Animals; D003131:Combined Modality Therapy; D003922:Diabetes Mellitus, Type 1 / Q000175:diagnosis / Q000276:immunology / Q000628:therapy*; D004195:Disease Models, Animal; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D016381:Islets of Langerhans Transplantation / Q000379:methods