Effect of mexiletine on dynamic allodynia induced by chronic constriction injury of the sciatic nerve in rats.
Static and dynamic allodynia occurred in a rat model of neuropathic pain induced by chronic constriction injury (CCI) of the sciatic nerve. Static allodynia was detected within 1 day after the CCI surgery, and persisted for 28 days. Dynamic allodynia displayed a slower course of development with a late onset, and statistically significant changes were achieved between 14 and 28 days after the surgery. Mexiletine at 10 and 30 mg/kg, s.c. produced a significant and dose-dependent inhibition of CCI-induced static and dynamic allodynia on day 14 post-surgery. Pregabalin, used as a reference drug, also significantly inhibited both static and dynamic allodynia at 30 and 60 mg/kg, p.o. These findings rationalize the clinical use of mexiletine for treatment of neuropathic pain.
Nakazato-Imasato
Etsuko
E
Nagoya Discovery Research, Pfizer Global Research and Development, Pfizer Inc., Aichi, Japan.
Tanimoto-Mori
Sachi
S
Kurebayashi
Yoichi
Y
D000700:Analgesics / Q000627:therapeutic use*; D000818:Animals; D002908:Chronic Disease; D003251:Constriction, Pathologic; D004305:Dose-Response Relationship, Drug; D006930:Hyperalgesia / Q000188:drug therapy*; D008801:Mexiletine / Q000627:therapeutic use*; D010147:Pain Measurement; D051381:Rats; D012584:Sciatic Nerve / Q000293:injuries*
D000700:Analgesics; D008801:Mexiletine