Update on animal models for HIV research.
Animal models for HIV research have been indispensible in fulfilling Koch's postulate and in exploring issues of viral infectivity and pathogenesis, sequence divergence, route(s) of acquisition, tissue distribution and tropism, immunogenicity and protection capacity of vaccine candidates, escape from adaptive immunity, and more. Did they fail to predict the efficacy of T-cell vaccines in humans? This article summarizes progress and status of models to inform and complement clinical work.
Haigwood
Nancy L
NL
Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA. haigwoon@ohsu.edu
D016915:AIDS Vaccines / Q000276:immunology; D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy* / Q000276:immunology / Q000821:virology; D000818:Animals; D023241:Antiretroviral Therapy, Highly Active; D000998:Antiviral Agents / Q000627:therapeutic use*; D035843:Biomedical Research / Q000379:methods / Q000639:trends; D004195:Disease Models, Animal; D015497:HIV-1 / Q000187:drug effects* / Q000276:immunology; D006801:Humans; D008251:Macaca / Q000276:immunology / Q000821:virology; D016097:Simian Acquired Immunodeficiency Syndrome / Q000188:drug therapy / Q000276:immunology / Q000821:virology; D015302:Simian Immunodeficiency Virus / Q000187:drug effects / Q000276:immunology
D016915:AIDS Vaccines; D000998:Antiviral Agents