title: Correlation of histological findings from a large ciliochoroidal melanoma with CT perfusion and 3T MRI dynamic enhancement studies.
abstract: BACKGROUND
  The initial use of a 64-slice computed tomography (CT) scanner for obtaining quantitative perfusion data from a large ciliochoroidal melanoma, and correlation with 3T magnetic resonance imaging (MRI) dynamic enhancement and tumor histology.
  
  
  METHODS
  The CT perfusion scan was performed using 80 kVp, 250 mA and 1-sec rotation time for 40 sec. The analysis was performed using commercial perfusion analysis software with a prototype 3-dimensional motion correction tool. Dynamic contrast-enhanced 3-Tesla MRI measured the kinetics of enhancement to estimate the vascular permeability. The time-dependent enhancement patterns were obtained using the average signal intensity using Functool analysis software. The involved globe was enucleated and microscopic evaluation of the tumor was performed.
  
  
  RESULTS
  The perfusion parameters blood flow, blood volume and permeability surface area product in the affected eye determined by CT perfusion analysis were 118 ml/100 ml/min, 11.3 ml/100 ml and 48 ml/100 ml/min. Dynamic MRI enhancement showed maximal intensity increase of 111%. The neoplasm was a ciliochoroidal spindle cell melanoma which was mitotically active (13 mitoses/40 hpf). Vascular loops and arcades were present throughout the tumor. The patient developed metastases within 9 months of presentation.
  
  
  CONCLUSIONS
  Quantitative CT perfusion analysis of ocular tumors is feasible with motion correction software.
authors: Department of Ophthalmology.
authors: Jose S
authors: JS
authors: Pulido
authors: Norbert G
authors: NG
authors: Campeau
authors: Ernst
authors: E
authors: Klotz
authors: Andrew N
authors: AN
authors: Primak
authors: Osama
authors: O
authors: Saba
authors: Kaan
authors: K
authors: Gunduz
authors: Herbert
authors: H
authors: Cantrill
authors: Diva
authors: D
authors: Salomão
authors: Cynthia H
authors: CH
authors: McCollough