title: A case of pediatric virilizing adrenocortical tumor resulting in hypothalamic-pituitary activation and central precocious puberty following surgical removal.
abstract: We present a 6-year-old boy with a virilizing adrenocortical tumor who initially presented with peripheral precocious puberty. Development of facial acne, pubic hair and a growth spurt were noted at the age of five. A low-pitched voice as well as maturation of external genitalia was noted at the age of six. Both serum and urinary levels of adrenal androgens were elevated. Abdominal computed tomography revealed a large right suprarenal mass and he underwent surgical resection without any complications. The histological diagnosis was adrenocortical carcinoma according to the criteria of Weiss. Following surgical removal of the androgen-producing tumor, the patient subsequently developed hypothalamic-pituitary activation and demonstrated central precocious puberty. He was treated with a gonadotropin-releasing hormone agonist in order to delay further pubertal progression. Clinical follow-up of potential secondary effects of excess hormone secretion after removal is important in some pediatric patients with virilizing adrenocortical tumor.
authors: Department of Pediatrics, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan.
authors: Yoko
authors: Y
authors: Miyoshi
authors: Takaharu
authors: T
authors: Oue
authors: Mitsugu
authors: M
authors: Oowari
authors: Hideki
authors: H
authors: Soh
authors: Makiko
authors: M
authors: Tachibana
authors: Sadami
authors: S
authors: Kimura
authors: Yuki
authors: Y
authors: Kiyohara
authors: Hiroyuki
authors: H
authors: Yamada
authors: Kazuhiko
authors: K
authors: Bessyo
authors: Sotaro
authors: S
authors: Mushiake
authors: Keiko
authors: K
authors: Homma
authors: Tomonobu
authors: T
authors: Hasegawa
authors: Hironobu
authors: H
authors: Sasano
authors: Keiichi
authors: K
authors: Ozono
mesh_terms: D000306:Adrenal Cortex Neoplasms / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology / Q000601:surgery*; D018268:Adrenocortical Carcinoma / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology / Q000601:surgery*; D000365:Age Determination by Skeleton; D002648:Child; D005260:Female; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism / Q000503:physiopathology*; D008297:Male; D011629:Puberty, Precocious / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology