[Importance of immunohistochemical studies in the diagnosis and the prognostic evaluation of cervical intraepithelial neoplasia and invasive squamous cell carcinoma of the uterine cervix. Review].
Immunohistochemical studies in cervical intraepithelial neoplasia and cervical carcinoma are evaluated in this review. A variety of proteins like p53, bcl2, C-Myc, Ki 67, Cyclines, P16 INK4a, p21, p27, beta-catenin, Wnt and MCM, have been related to the development of cervical neoplasia and human papilloma virus infection. It is described how transcriptional factors of genes induce loss of heterozygosity, numerical chromosome abnormality and inactivation of gene products or the partial loss of some membrane glycoproteins induced by oncogenic human papillomaviruses (HPV).
García-Tamayo
Jorge
J
Laboratorio de Patología Molecular Novapath, Centro Comercial La Paragüita, local 13, Prolongación de la Circunvalación No 2. Maracaibo, Venezuela. novapath@yahoo.com
Molina
Julia
J
Blasco-Olaetxea
Eduardo
E
D014408:Biomarkers, Tumor / Q000032:analysis*; D001789:Blood Group Antigens / Q000032:analysis; D002294:Carcinoma, Squamous Cell / Q000737:chemistry / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D005260:Female; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D015967:Gene Expression Regulation, Viral; D052138:Genes, Neoplasm; D005814:Genes, Viral; D006801:Humans; D009154:Mutation; D009363:Neoplasm Proteins / Q000032:analysis; D009856:Oncogene Proteins, Viral / Q000032:analysis; D027383:Papillomaviridae / Q000145:classification / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity; D030361:Papillomavirus Infections / Q000175:diagnosis / Q000473:pathology; D011379:Prognosis; D002583:Uterine Cervical Neoplasms / Q000737:chemistry / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D002578:Uterine Cervical Dysplasia / Q000737:chemistry / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology
D014408:Biomarkers, Tumor; D001789:Blood Group Antigens; D009363:Neoplasm Proteins; D009856:Oncogene Proteins, Viral