title: Relationship of vitamin D and parathyroid hormone with obesity and body composition in African Americans.
abstract: BACKGROUND
  Obesity disproportionately affects African Americans (AA) (especially women), and is linked to depressed 25-hydroxyvitamin D (25-OH D) and elevated parathyroid hormone (PTH). The relationship of 25-OH D and PTH with body composition and size in AA is not well known.
  
  
  OBJECTIVE
  To determine the relationship of 25-OH D and PTH levels with body composition and anthropometric measures.
  
  
  METHODS
  A cross-sectional study was conducted in 98 healthy, overweight, adult AA enrolled in an NIH/NIEHS-sponsored weight loss/salt-sensitivity trial.
  
  
  METHODS
  Multivariable linear regression analyses were used to explore the relationship of 25-OH D and PTH with body composition, determined by dual-energy X-ray absorptiometry, and anthropometric measures. Body composition and size were contrasted across vitamin D/PTH groups using general linear models: (i) normal (25-OH D >50 nmol/l, PTH <or=65 pg/ml), (ii) low 25-OH D and normal PTH and (iii) low 25-OH D and high PTH.
  
  
  RESULTS
  Age, gender and season-adjusted regression analyses showed that PTH was directly correlated with total (P = 0.02), truncal (P = 0.03) and extremity (P = 0.03) fat mass, while 25-OH D was inversely related to truncal fat mass (P = 0.02). Total fat mass in groups 1-3, respectively, was 30.0, 34.0 and 37.4 kg (P = 0.008); truncal fat mass was 13.4, 15.9 and 17.6 kg (P = 0.006) and extremity fat mass was 15.8, 16.9 and 19.7 kg (P = 0.02). Lean mass did not differ across the three groups.
  
  
  CONCLUSIONS
  Our findings show that lower 25-OH D and raised PTH are both correlated, though in opposite directions, with fat mass, fat distribution and anthropometric measures in adult AA.
authors: Department of Physiology, Wayne State University, School of Medicine, Detroit, MI 48201, USA. avalina@med.wayne.edu
authors: Anna Liza B
authors: AL
authors: Valiña-Tóth
authors: Zongshan
authors: Z
authors: Lai
authors: Wonsuk
authors: W
authors: Yoo
authors: Abdul
authors: A
authors: Abou-Samra
authors: Crystal A
authors: CA
authors: Gadegbeku
authors: John M
authors: JM
authors: Flack
mesh_terms: D015502:Absorptiometry, Photon; D000328:Adult; D001741:Black or African American / Q000706:statistics & numerical data*; D001823:Body Composition; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009765:Obesity / Q000097:blood*; D010281:Parathyroid Hormone / Q000097:blood*; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood
chemical_list: D010281:Parathyroid Hormone; D014807:Vitamin D; C104450:25-hydroxyvitamin D