Alkaline sucrose as a solvent for delivery of water-insoluble drugs.
Alkaline sucrose solution was demonstrated to be a good solvent for the solubilization of water-insoluble drugs. At high concentration and alkaline pH, sucrose solubilizes water-insoluble molecules through intramolecular conformations. Tetracyline and chloramphenicol, when dissolved in alkaline sucrose solution, retained their bactericidal activity. Gel permeation-chromatography analysis and atomic-force-microscopy studies confirmed the formation of sucrose-antibiotics complex.
Shah
V
V
Department of Biology, Dowling College, Oakdale, NY 11955, USA. ShahV@dowling.edu
Badia
D
D
Kudasheva
D
D
D000468:Alkalies / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000737:chemistry; D001419:Bacteria / Q000187:drug effects; D002701:Chloramphenicol / Q000008:administration & dosage* / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods*; D008826:Microbial Sensitivity Tests; D019999:Pharmaceutical Solutions; D012995:Solubility; D012997:Solvents / Q000737:chemistry; D013395:Sucrose / Q000737:chemistry*; D013754:Tetracyclines / Q000008:administration & dosage* / Q000737:chemistry; D014867:Water / Q000737:chemistry
D000468:Alkalies; D000900:Anti-Bacterial Agents; D019999:Pharmaceutical Solutions; D012997:Solvents; D013754:Tetracyclines; D014867:Water; D013395:Sucrose; D002701:Chloramphenicol