Electrospinning of collagen/biopolymers for regenerative medicine and cardiovascular tissue engineering.
The process of electrospinning has seen a resurgence of interest in the last few decades which has led to a rapid increase in the amount of research devoted to its use in tissue engineering applications. Of this research, the area of cardiovascular tissue engineering makes up a large percentage, with substantial resources going towards the creation of bioresorbable vascular grafts composed of electrospun nanofibers of collagen and other biopolymers. These bioresorbable grafts have compositions that allow for the in situ remodeling of the structure, with the eventual replacement of the graft with completely autologous tissue. This review will highlight some of the work done in the field of electrospinning for cardiovascular applications, with an emphasis on the use of biopolymers such as collagens, elastin, gelatin, fibrinogen, and silk fibroin, as well as biopolymers used in combination with resorbable synthetic polymers.
Sell
Scott A
SA
Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, 23284-3067, USA.
McClure
Michael J
MJ
Garg
Koyal
K
Wolfe
Patricia S
PS
Bowlin
Gary L
GL
D000818:Animals; D040761:Biomimetic Materials / Q000737:chemistry; D032701:Biomimetics / Q000295:instrumentation / Q000379:methods*; D001704:Biopolymers / Q000737:chemistry*; D002319:Cardiovascular System; D003094:Collagen / Q000737:chemistry*; D004563:Electrochemistry; D006801:Humans; D044968:Regenerative Medicine; D023822:Tissue Engineering / Q000295:instrumentation / Q000379:methods*
D001704:Biopolymers; D003094:Collagen