title: Changing patterns of bleeding in patients with severe haemophilia A.
abstract: Previous studies on the pattern of joint bleeding in patients with haemophilia have reported that the knee joint is most frequently affected. Home treatment data reporting bleeding frequency and location collected from 100 patients registered at six haemophilia centres in the UK have been analysed to determine current patterns of bleeding. Bleeding frequency has markedly decreased although bleeding into joints remains the main characteristic of haemophilia. However, the ankle joint has replaced the knee joint as the most common joint affected. Furthermore, it seems that the frequency of knee joint bleeding is also less than the elbow joint suggesting that the traditional pattern of joint bleeding in haemophilia has now changed significantly.
authors: Kent Haemophilia Centre, Kent and Canterbury Hospital, Canterbury, UK. david.stephensen@ekht.nhs.uk
authors: D
authors: D
authors: Stephensen
authors: R C
authors: RC
authors: Tait
authors: N
authors: N
authors: Brodie
authors: P
authors: P
authors: Collins
authors: R
authors: R
authors: Cheal
authors: D
authors: D
authors: Keeling
authors: K
authors: K
authors: Melton
authors: G
authors: G
authors: Dolan
authors: H
authors: H
authors: Haye
authors: E
authors: E
authors: Hayman
authors: M
authors: M
authors: Winter
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000843:Ankle Joint / Q000502:physiology*; D002648:Child; D004551:Elbow Joint / Q000502:physiology*; D005169:Factor VIII / Q000627:therapeutic use; D006395:Hemarthrosis / Q000150:complications* / Q000453:epidemiology / Q000503:physiopathology; D006467:Hemophilia A / Q000150:complications* / Q000453:epidemiology / Q000503:physiopathology; D006801:Humans; D007719:Knee Joint / Q000502:physiology*; D008297:Male; D016059:Range of Motion, Articular / Q000502:physiology; D012189:Retrospective Studies; D012648:Self Care; D016474:Weight-Bearing / Q000502:physiology*; D055815:Young Adult
chemical_list: D005169:Factor VIII