Triazole-Au(I) complexes: a new class of catalysts with improved thermal stability and reactivity for intermolecular alkyne hydroamination.
A series of 1,2,3-triazole-bound cationic Au(I) catalysts have been synthesized, and their structures have been characterized by X-ray crystallography. Variable-temperature NMR studies revealed dynamic triazole-Au cation coordination in solution. Reaction profiles clearly indicated that these new catalysts possess much better thermal stability than literature-reported Au catalysts, including IPrAu x NTf(2). By application of these catalysts, challenging intermolecular hydroaminations were achieved with less-reactive internal alkynes and unprotected aliphatic amines, giving excellent yields with low catalyst loading.
Duan
Haifeng
H
C. Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, West Virginia 26506, USA.
Sengupta
Sujata
S
Petersen
Jeffrey L
JL
Akhmedov
Novruz G
NG
Shi
Xiaodong
X