Four new fatty acid esters from the Feces of Trogopterus xanthipes.
Four new fatty acid esters have been isolated from Feces Trogopterus. Their structures were determined by spectroscopic and chemical methods to be bis(7-hydroxyheptyl) icosanedioate (1), bis(7-hydroxyheptyl) heptadecanedioate (2), bis(7-hydroxyheptyl) decanedioate (3), and bis(7-hydroxyheptyl) octanedioate (4). In the anticoagulative assay, compounds 3 and 4 had significant antithrombin activity.
Yang
Nian-Yun
NY
Jiangsu Key Laboratory for TCM Formulae Research, Nanjing University of Traditional Chinese Medicine, Nanjing, 210046, People's Republic of China.
Tao
Wei-Wei
WW
Duan
Jin-Ao
JA
Guo
Jian-Ming
JM
Cao
Ling-Ling
LL
D000818:Animals; D000925:Anticoagulants / Q000032:analysis* / Q000302:isolation & purification / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000032:analysis / Q000302:isolation & purification / Q000494:pharmacology; D005227:Fatty Acids / Q000032:analysis* / Q000302:isolation & purification / Q000494:pharmacology*; D005243:Feces / Q000737:chemistry*; D015394:Molecular Structure; D011817:Rabbits; D012589:Sciuridae / Q000378:metabolism*; D013917:Thrombin / Q000037:antagonists & inhibitors / Q000378:metabolism
D000925:Anticoagulants; D004365:Drugs, Chinese Herbal; D005227:Fatty Acids; D013917:Thrombin