HorC, a hop-resistance related protein, presumably functions in homodimer form.
To determine whether two HorC molecules coordinately form a single unit, the functional properties of covalently linked dimers of HorC encoded by tandemly fused horC genes were studied. Lactobacillus brevis introduced with the fused horC genes and a single horC gene exhibited same degree of resistance to hop compounds and cetyltrimethylammonium bromide. This suggests that HorC functions as a homodimer.
Iijima
Kazumaru
K
Research Laboratories of Brewing Technology, Asahi Breweries, Ltd., Moriya, Ibaraki, Japan.
Suzuki
Koji
K
Asano
Shizuka
S
Ogata
Tomoo
T
Kitagawa
Yasushi
Y
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D001515:Beer / Q000382:microbiology*; D000077286:Cetrimonium; D002593:Cetrimonium Compounds / Q000494:pharmacology; D024881:Drug Resistance, Bacterial; D015964:Gene Expression Regulation, Bacterial; D006801:Humans; D055503:Protein Multimerization; D020836:Protein Structure, Quaternary
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D002593:Cetrimonium Compounds; D000077286:Cetrimonium