Microfluidic devices for measuring gene network dynamics in single cells.
The dynamics governing gene regulation have an important role in determining the phenotype of a cell or organism. From processing extracellular signals to generating internal rhythms, gene networks are central to many time-dependent cellular processes. Recent technological advances now make it possible to track the dynamics of gene networks in single cells under various environmental conditions using microfluidic 'lab-on-a-chip' devices, and researchers are using these new techniques to analyse cellular dynamics and discover regulatory mechanisms. These technologies are expected to yield novel insights and allow the construction of mathematical models that more accurately describe the complex dynamics of gene regulation.
Bennett
Matthew R
MR
Department of Biochemistry and Cell Biology and Institute of Biosciences and Bioengineering, Rice University, 6100 Main Street, Houston, Texas 77005-1892, USA. matthew.bennett@rice.edu
Hasty
Jeff
J
D000818:Animals; D002477:Cells / Q000166:cytology / Q000378:metabolism*; D005786:Gene Expression Regulation; D053263:Gene Regulatory Networks / Q000502:physiology*; D049452:Green Fluorescent Proteins / Q000032:analysis; D006801:Humans; D007700:Kinetics; D046210:Microfluidic Analytical Techniques / Q000639:trends; D008954:Models, Biological
D049452:Green Fluorescent Proteins