Epistasis between a set of variations located in the TAAR6 and HSP-70 genes toward schizophrenia and response to antipsychotic treatment.
Suggestive associations have been reported between trace amines and heat shock proteins, and a disrupted pathophysiology that enhances the risk of psychosis and that modifies responses to antipsychotic treatments. Our group previously reported genetic studies on TAAR6 and HSP-70 separately in patients with schizophrenia. In the current study, we investigated possible epistasis between the same set of variations in a sample of 281 patients diagnosed with schizophrenia and 288 healthy controls. We applied the generalized multifactor dimensionality reduction (MDR) method and controlled covariates significantly associated with both diagnosis and treatment efficacy. To the best of our knowledge, epistasis between the present set of variations in schizophrenia has not been tested before. We found significant associations with both the risk of disease and response to treatment. However, the insufficiently balanced accuracy of the applied tests suggests that, despite significantly different genetic variations between cases and controls, these factors have a poor predictive value. Explanations for these findings and possible future directions are also discussed.
Pae
Chi-Un
CU
Department of Psychiatry, The Catholic University of Korea College of Medicine, Seocho-Gu, Seoul 150-713, Republic of Korea. pae@catholic.ac.kr
Drago
Antonio
A
Patkar
Ashwin A
AA
Jun
Tae-Youn
TY
Serretti
Alessandro
A
D014150:Antipsychotic Agents / Q000627:therapeutic use*; D018797:Cell Cycle Proteins / Q000235:genetics*; D004843:Epistasis, Genetic; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D050884:HSP72 Heat-Shock Proteins / Q000235:genetics*; D006801:Humans; D009687:Nuclear Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011569:Psychiatric Status Rating Scales; D043562:Receptors, G-Protein-Coupled; D012559:Schizophrenia / Q000188:drug therapy / Q000235:genetics; D012565:Schizophrenic Psychology; D000095383:Trace Amine-Associated Receptors
D014150:Antipsychotic Agents; D018797:Cell Cycle Proteins; D050884:HSP72 Heat-Shock Proteins; D009687:Nuclear Proteins; D043562:Receptors, G-Protein-Coupled; C493988:TAAR6 protein, human; D000095383:Trace Amine-Associated Receptors