title: Serum and tissue selenium levels in gastric cancer patients and correlation with CEA.
abstract: BACKGROUND
  An inverse relationship between selenium (Se) intake and cancer mortality is evident in humans.
  
  
  METHODS
  In eighty patients who had been operated on for primary gastric cancer, serum Se and carcinoembryonic antigen (CEA) levels were measured preoperatively using a fluorometric and immunoradiometric assay (IRMA), respectively.
  
  
  RESULTS
  The serum Se levels were 43+/-6.3 microg l(-1) in the patient group and 68.7+/-4.5 microg l(-1) in healthy individuals (p<0.001). The serum CEA was 12+/-1.9 U ml(-1) in the gastric cancer patients and 2.1 U ml(-1) in the control group (p<0.001). The Se tissue concentrations were 2,640+/-220 mg g(-1) in excised neoplastic tissue and 685+/-115 mg g(-1) in non-neoplastic tissue (p<0.001). An inverse correlation between Se and CEA serum levels was found (r=-0.782). There was no correlation between serum/tissue Se concentration and disease stage/histological type or gender in the patient group.
authors: Department of Physiology, Medical Faculty, University of Ioannina, Ioannina, Greece. kcharala@cc.uoi.gr
authors: Konstantinos
authors: K
authors: Charalabopoulos
authors: Athanasios
authors: A
authors: Kotsalos
authors: Anna
authors: A
authors: Batistatou
authors: Alexander
authors: A
authors: Charalabopoulos
authors: Dimitrios
authors: D
authors: Peschos
authors: Patra
authors: P
authors: Vezyraki
authors: Vicky
authors: V
authors: Kalfakakou
authors: Apostolos
authors: A
authors: Metsios
authors: Anestis
authors: A
authors: Charalampopoulos
authors: Anastasios
authors: A
authors: Macheras
authors: Niki
authors: N
authors: Agnantis
authors: Agelos
authors: A
authors: Evangelou
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000556:secondary; D014408:Biomarkers, Tumor / Q000097:blood*; D002272:Carcinoembryonic Antigen / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D005470:Fluorometry; D006801:Humans; D007124:Immunoenzyme Techniques; D015592:Immunoradiometric Assay; D007414:Intestinal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D012643:Selenium / Q000378:metabolism*; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D012643:Selenium