Influence of genetic polymorphisms of glutathione S-transferase T1 (GSTT1) and M1 (GSTM1) on hematological parameters.
To find the influence of genetic polymorphisms of glutathione S-transferases M1 (GSTM1) and T1 (GSTT1) on hematological parameters in smoker and non-smoker subjects, the present study was done. This cross-sectional study was conducted on 97 healthy males (24 smokers, 73 non-smokers). The genotypes were determined using a polymerase chain reaction based method. In non-smokers, there was no statistically association between number of active genes and the study parameters. However, in smokers, RBC count was significantly decreased in null genotypes of GSTT1 (t = 3.021, df = 22, P = 0.006) and GSTM1 (t = 2.141, df = 22, P = 0.044). Also, in smokers, RBC count significantly decreased in persons having GSTM1 and GSTT1 null genotypes in comparison with subjects having two active genes (F = 5.554; df = 2, 21; P = 0.012). Because elevated RBC count correlate well with risk of coronary heart disease, it might be concluded that GSTM1 and GSTT1 null genotypes have protective role(s) for developing coronary heart disease.
Saadat
Iraj
I
Department of Biology, College of Sciences, Shiraz University, Shiraz, Iran.
Saadat
Mostafa
M
D000328:Adult; D000375:Aging / Q000235:genetics; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006439:Hemodynamics; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D012907:Smoking / Q000235:genetics
D005982:Glutathione Transferase; C413545:glutathione S-transferase T1