title: [Use of multilayer amniotic membrane as first therapy for penetrating corneal ulcers].
abstract: BACKGROUND
  A corneal penetration secondary to inflammation or chronic trophic disease is an emergency situation in ophthalmology. The ocular globe is instable and there is a significant risk of an endophthalmitis. A corneal graft for a tectonic transplantation may not be available in many cases. The prognosis of an emergency corneal transplantation is relatively poor. We report the results of multilayer amniotic membrane transplantation as initial therapy for penetrating corneal ulcers.
  
  
  METHODS
  In 13 eyes with penetrating corneal ulcers an initial therapy with multilayer amniotic membrane was performed. All patients (11 men, 2 women; age 52-90 years; mean 71.7 years) were given therapeutic contact lenses as well as systemic and local antibiotics. We investigated the postoperative course with regard to stabilisation of the cornea and deepening of the anterior chamber.
  
  
  RESULTS
  The anterior chamber was reestablished in 8 of 13 patients (62%) after an average of 5.25 days (range, 1-15) using multi-layer amniotic membrane transplantation.
  
  
  CONCLUSIONS
  Our data show that an initial treatment of penetrating corneal ulcers with multilayer amniotic membrane is reasonable. With this procedure the surgeon gains sufficient time for obtain a corneal graft for a possible penetrating corneal transplantation.
authors: Klinik für Augenheilkunde, Goethe-Universität, Frankfurt am Main.
authors: M
authors: M
authors: Müller
authors: C
authors: C
authors: Meltendorf
authors: A
authors: A
authors: Mirshahi
authors: T
authors: T
authors: Kohnen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001684:Biological Dressings; D065306:Corneal Injuries; D003320:Corneal Ulcer / Q000175:diagnosis* / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D014950:Wounds, Penetrating / Q000175:diagnosis* / Q000628:therapy*