title: Evaluation of factors associated with elevated levels of platelet-derived microparticles in the acute phase of cerebral infarction.
abstract: BACKGROUND
  Platelet-derived microparticles (PDMPs) have attracted attention as blood coagulation-promoting, endothelial cell-activating factors. The objective of this study was to determine the parameters associated with elevated PDMP levels and examine their relationship with atherosclerotic lesions of main intracranial and extracranial arteries.
  
  
  METHODS
  Participants included a control group (C) of 61 patients with no apparent cerebral vascular lesions and 110 patients with acute-phase cerebral infarction, consisting of a small-vessel occlusion group (S) of 34 patients, a large-artery atherosclerosis group (L) of 41 patients, a cardioembolism group (CE) of 20 patients, and a stroke of undetermined etiology group (U) of 15 patients. Platelet-derived microparticle levels were measured using enzyme-linked immunosorbent assay (ELISA) at the time of admission, and the patients were reclassified into group CP (control level PDMPs), consisting of 70 patients with control PDMP levels, and group HP (high PDMPs), consisting of 40 patients with elevated PDMP levels. All patients underwent cranial magnetic resonance (MR) and carotid ultrasound examinations.
  
  
  RESULTS
  Platelet-derived microparticle levels were significantly higher in groups S and L than in group C (P < .01). Concomitant intima-media thickness (IMT; odds ratio [OR] = 1.29, P < .05) and concomitant intracranial stenosis (OR = 3.95, P < .01) were significantly correlated with elevated PDMP levels. Fibrinogen and high-sensitivity CRP levels were significantly higher in group HP than in group CP.
  
  
  CONCLUSIONS
  Alterations in PDMP levels correlated with the presence of atherothrombotic lesions, and PDMP levels are expected to be useful as a clinical indicator, reflecting the presence of intracranial atherosclerotic lesions in the acute phase of cerebral infarction.
authors: Department of Neurology, Kyoto Prefectural University of Medicine, Kyoto, Japan. nkuriyam@koto.kpu-m.ac.jp
authors: Nagato
authors: N
authors: Kuriyama
authors: Yoshinari
authors: Y
authors: Nagakane
authors: Akiko
authors: A
authors: Hosomi
authors: Tomoyuki
authors: T
authors: Ohara
authors: Takashi
authors: T
authors: Kasai
authors: Sanae
authors: S
authors: Harada
authors: Kazuo
authors: K
authors: Takeda
authors: Kei
authors: K
authors: Yamada
authors: Kotaro
authors: K
authors: Ozasa
authors: Takahiko
authors: T
authors: Tokuda
authors: Yoshiyuki
authors: Y
authors: Watanabe
authors: Toshiki
authors: T
authors: Mizuno
authors: Masanori
authors: M
authors: Nakagawa
mesh_terms: D000208:Acute Disease; D000368:Aged; D015415:Biomarkers / Q000097:blood*; D001792:Blood Platelets / Q000473:pathology*; D002097:C-Reactive Protein / Q000378:metabolism; D002340:Carotid Artery Diseases / Q000097:blood / Q000000981:diagnostic imaging / Q000473:pathology; D055252:Cell-Derived Microparticles / Q000473:pathology*; D002544:Cerebral Infarction / Q000097:blood* / Q000473:pathology*; D018450:Disease Progression; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D002537:Intracranial Arteriosclerosis / Q000097:blood / Q000473:pathology; D016015:Logistic Models; D018810:Magnetic Resonance Angiography; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D014463:Ultrasonography
chemical_list: D015415:Biomarkers; D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D; D005340:Fibrinogen; D002097:C-Reactive Protein