Changing Clostridium difficile infection testing and treatment trends at a large tertiary care teaching hospital.
OBJECTIVE
To assess changes in testing and treatment trends of CDI at a time when the Clostridium difficile hypervirulent strain was first identified.


METHODS
A retrospective cohort study was performed. C. difficile cytotoxicity results were merged with pharmacy databases and changes in testing and treatment pattern over time were assessed.


RESULTS
6,613 tests for C. difficile were performed on 5,100 patients. Using least squares regression times series analysis, rates of testing increased by 0.63 +/- 0.31 tests per month (P = 0.05) although the number of positive tests did not increase significantly. Overall, metronidazole was the most commonly used drug (81.6%), followed by vancomycin (9.3%), rifaximin (8.4%), and nitazoxanide (0.70%). Use of rifaximin increased by 3.3 +/- 0.55 new prescriptions per month (Fig. 2; P < 0.01) while use of metronidazole increased by 5.0 +/- 2.8 new prescriptions per month and oral vancomycin increased by 0.4 +/- 0.7 new prescriptions per month; however these results were not statistically significant. For patients receiving rifaximin the drug was given as monotherapy (26.2%), in combination with oral vancomycin (24.2%), or in combination with metronidazole (49.7%).


CONCLUSIONS
Increased rates of CDI testing and use of alternative therapies was observed at a time when the hypervirulent strain was first identified.
Salazar
Miguel
M
St. Luke's Episcopal Hospital, Houston, TX, 77030, USA.
Garey
Kevin W
KW
University of Houston College of Pharmacy, Houston, TX, 77030, USA. kgarey@uh.edu.
Jiang
Zhi-Dong
ZD
University of Texas School of Public Health, Houston, TX, 77030, USA.
Dao-Tran
Thanh
T
St. Luke's Episcopal Hospital, Houston, TX, 77030, USA.
DuPont
Herbert
H
University of Texas School of Public Health, Houston, TX, 77030, USA.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016360:Clostridioides difficile / Q000302:isolation & purification*; D003015:Clostridium Infections / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy*; D015331:Cohort Studies; D005260:Female; D006784:Hospitals, Teaching / Q000592:standards / Q000639:trends*; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests / Q000592:standards / Q000639:trends; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult