Base and copper(I) catalyzed Mannich, alkyne hydroamination cascades for the direct synthesis of 2-methylenepyrrolidines.
An efficient, simple-to-perform, one-pot reaction cascade to 2-methylenepyrrolidines from p-toluenesulfonyl protected imines and propargylated malonates under a combination of base and copper(I) catalysis is reported.
Wang
Hai-Fei
HF
State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, PR China.
Yang
Ting
T
Xu
Peng-Fei
PF
Dixon
Darren J
DJ
D000480:Alkynes / Q000737:chemistry*; D000586:Amination; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D007097:Imines / Q000737:chemistry; D008314:Malonates / Q000737:chemistry; D008352:Mannich Bases / Q000737:chemistry*; D011759:Pyrrolidines / Q000737:chemistry*
D000480:Alkynes; D007097:Imines; D008314:Malonates; D008352:Mannich Bases; D011759:Pyrrolidines; D003300:Copper