Identification of 3-hydroxy-2-(3-hydroxyphenyl)-4H-1-benzopyran-4-ones as isoform-selective PKC-zeta inhibitors and potential therapeutics for psychostimulant abuse.
From a screen of small molecule libraries to identify potential therapeutics for psychostimulant abuse, 3-hydroxy-2-(3-hydroxyphenyl)-4H-1-benzopyran-4-ones were shown to be isoform-selective PKC-zeta inhibitors.
Yuan
Langtian
L
Department of Chemistry, Duke University, Durham, North Carolina 27708, USA.
Seo
Jin-Soo
JS
Kang
Nam Sook
NS
Keinan
Shahar
S
Steele
Sarah E
SE
Michelotti
Gregory A
GA
Wetsel
William C
WC
Beratan
David N
DN
Gong
Young-Dae
YD
Lee
Tong H
TH
Hong
Jiyong
J
D000704:Analysis of Variance; D000818:Animals; D001578:Benzopyrans; D019556:COS Cells; D002522:Chlorocebus aethiops; D005419:Flavonoids / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D007700:Kinetics; D008958:Models, Molecular; D020033:Protein Isoforms; D011493:Protein Kinase C / Q000037:antagonists & inhibitors* / Q000378:metabolism; D047428:Protein Kinase Inhibitors / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D054852:Small Molecule Libraries; D013379:Substrate Specificity; D000099221:Protein Kinase C zeta
D001578:Benzopyrans; D005419:Flavonoids; D020033:Protein Isoforms; D011493:Protein Kinase C; D047428:Protein Kinase Inhibitors; D054852:Small Molecule Libraries; D000099221:Protein Kinase C zeta