Constituents of the leaves of Magnolia ovata.
Two new lignans, magnovatins A (1) and B (2), along with nine known compounds, were isolated from the leaves of Magnolia ovata. The known compounds were identified as acuminatin (3), licarin A (4), kadsurenin M, 4-O-demethylkadsurenin M, oleiferin A, oleiferin C, spathulenol, parthenolide, and 11,13-dehydrocompressanolide. In addition, compounds 1 and 2 yielded four new derivatives (1a, 1b, 2a, and 2b). The structures of the new compounds were established on the basis of spectrometric data evaluation. Free-radical scavenging and antimicrobial activities of the major compunds 1, 3, and 4 were investigated.
Barros
Letícia Ferrari L
LF
Departamento de Quimica, Universidade Federal do Parana, CP 19081, 81530-900 Curitiba, PR, Brazil.
Barison
Andersson
A
Salvador
Marcos José
MJ
de Mello-Silva
Renato
R
Cabral
Elaine C
EC
Eberlin
Marcos N
MN
Stefanello
Maria Elida A
ME
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001938:Brazil; D004926:Escherichia coli / Q000187:drug effects; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006027:Glycosides / Q000302:isolation & purification / Q000494:pharmacology; D017705:Lignans / Q000302:isolation & purification / Q000494:pharmacology; D031566:Magnolia / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013212:Staphylococcus epidermidis / Q000187:drug effects; D015003:Yeasts / Q000187:drug effects
D000900:Anti-Bacterial Agents; D005419:Flavonoids; D016166:Free Radical Scavengers; D006027:Glycosides; D017705:Lignans; C432503:licarin A; C077860:acuminatin