Age of greatest susceptibility to childhood lead exposure: a new statistical approach.
BACKGROUND
Susceptibility to lead toxicity is often assumed to be greatest during early childhood (e.g., 2 years of age), but recent studies suggest that blood lead concentrations (BPb) taken at 5-7 years of age are more strongly associated with IQ.


OBJECTIVE
We aimed to determine the age of greatest susceptibility to lead exposure using an innovative statistical approach that avoids the problem of correlated serial BPb measurements.


METHODS
We analyzed two cohorts of children that were followed from infancy to 6 years of age in Rochester, New York (n = 211), and Cincinnati, Ohio (n = 251). Serial BPb levels were measured and IQ tests were done when children were 6 years of age. After adjustment for relevant covariates, the ratio of 6-year BPb to 2-year BPb was added to the multiple regression model to test whether the pattern of BPb profiles during childhood had additional effect on IQ.


RESULTS
The ratio of BPb at 6 years to the BPb at 2 years showed a strong effect on IQ (p < .001) when added to the multiple regression model that included the average childhood BPb. IQ decreased by 7.0 points for children whose BPb at 6 years of age was 50% greater than that at 2 years compared with children whose 6-year BPb was 50% less than their 2-year BPb. Similarly, criminal arrest rates were a factor of 3.35 higher for those subjects whose 6-year BPb was 50% higher than their 2-year BPb.


CONCLUSIONS
We conclude that 6-year BPb is more strongly associated with cognitive and behavioral development than is BPb measured in early childhood.
Hornung
Richard W
RW
Cincinnati Children's Environmental Health Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229-3039, USA. richard.hornung@cchmc.org
Lanphear
Bruce P
BP
Dietrich
Kim N
KN
D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D003627:Data Interpretation, Statistical; D004198:Disease Susceptibility; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007854:Lead / Q000097:blood*; D007855:Lead Poisoning / Q000453:epidemiology*; D008297:Male; D012044:Regression Analysis
D007854:Lead