title: Axon growth-stimulus package includes local translation.
abstract: Translation of localized mRNAs is an important mechanism for controlling spatially discrete cellular processes. The polarity protein Par-3 is locally translated in axons in response to factors such as NGF and netrin-1, and this increased expression is necessary for factor-stimulated axonal outgrowth.
authors: Ian G. Macara, Hidekazu Iioka and Stavroula Mili are in the Center for Cell Signaling, University of Virginia, Charlottesville, VA 22908-0577, USA. igm9c@virginia.edu
authors: Ian G
authors: IG
authors: Macara
authors: Hidekazu
authors: H
authors: Iioka
authors: Stavroula
authors: S
authors: Mili
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D001369:Axons / Q000187:drug effects* / Q000378:metabolism; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism; D002478:Cells, Cultured; D015870:Gene Expression / Q000187:drug effects; D008954:Models, Biological; D020932:Nerve Growth Factor / Q000494:pharmacology*; D009414:Nerve Growth Factors / Q000494:pharmacology*; D009419:Nerve Tissue Proteins; D000075388:Netrin-1; D009474:Neurons / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D011485:Protein Binding; D014176:Protein Biosynthesis / Q000187:drug effects*; D011493:Protein Kinase C / Q000235:genetics / Q000378:metabolism; D051381:Rats; D015398:Signal Transduction; D025521:Tumor Suppressor Proteins / Q000494:pharmacology*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins; D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins; C000617354:Ntn1 protein, rat; C472451:Pard3 protein, rat; C504908:Pard6a protein, rat; D025521:Tumor Suppressor Proteins; D000075388:Netrin-1; D020932:Nerve Growth Factor; C115015:PKC-3 protein; D011493:Protein Kinase C