Haplofungins, novel inositol phosphorylceramide synthase inhibitors, from Lauriomyces bellulus SANK 26899 III. Absolute structure of haplofungin A.
The absolute structure of haplofungin A, a potent fungal inositol phosphoceramide (IPC) synthase inhibitor from Lauriomyces bellulus SANK 26899, was determined by chiral GC/MS analysis, NMR and X-ray crystallographic analysis of the derivatives of degradation products.
Ohnuki
Takashi
T
Exploratory Research Laboratories I, Daiichi Sankyo Co. Ltd, Hiromachi, Shinagawa-ku, Tokyo, Japan. ohnuki.takashi.eh@daiichisankyo.co.jp
Yano
Tatsuya
T
Furukawa
Youji
Y
Takatsu
Toshio
T
D000935:Antifungal Agents / Q000737:chemistry* / Q000378:metabolism; D001203:Ascomycota / Q000145:classification / Q000254:growth & development / Q000378:metabolism*; D018360:Crystallography, X-Ray; D003470:Culture Media; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000378:metabolism; D005231:Fatty Acids, Unsaturated / Q000737:chemistry* / Q000378:metabolism; D008401:Gas Chromatography-Mass Spectrometry; D006602:Hexosyltransferases / Q000037:antagonists & inhibitors*; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation
D000935:Antifungal Agents; D003470:Culture Media; D004791:Enzyme Inhibitors; D005231:Fatty Acids, Unsaturated; D006602:Hexosyltransferases; C088714:phosphatidylinositol-ceramide phosphoinositol transferase