title: Efficacy and safety of combination therapy with latanoprost after a change in therapeutic regimen from timolol to brinzolamide in Japanese adult patients with primary open-angle glaucoma and ocular hypertension: open, non-randomized 12-week study.
abstract: OBJECTIVE
  To compare the efficacy of brinzolamide in Japanese patients with primary open-angle glaucoma (POAG) or ocular hypertension (OH) after a change from timolol in combination therapy with latanoprost.
  
  
  METHODS
  A 12-week, prospective, open-label, comparative study was performed in 20 patients [11 males and 9 females, mean age of 64.5 +/- 11.0 (SD)y] with POAG or OH treated with both latanoprost once daily and timolol 0.5% twice daily. During the study brinzolamide was substituted for timolol. Intraocular pressure (IOP) was measured at baseline, 4, 8, and 12 weeks. Blood pressure (BP), pulse rate (PR), and adverse events were also recorded.
  
  
  RESULTS
  IOPs at baseline, 4, 8, and 12 weeks were 18.6 +/- 2.1 mmHg, 17.8 +/- 2.6 mmHg, 17.4 +/- 2.5 mmHg, and 17.3 +/- 3.5 mmHg, respectively. IOP reduction at 4 and 8 weeks was statistically significant (p < 0.05). The PR was significantly increased at 12 weeks (p < 0.01), but BP was not significantly affected. Four ocular adverse events were noted, but all were mild and transient.
  
  
  CONCLUSIONS
  Substituting brinzolamide 1% for timolol 0.5% in combination therapy with latanoprost 0.005% demonstrated significant IOP reduction with improvement in PR with POAG or OH. Combination therapy using latanoprost and brinzolamide may be recommended for better IOP control with fewer systemic adverse events.
authors: Department of Ophthalmology, University of the Ryukyus Faculty of Medicine, Okinawa, Japan.
authors: Shusaku
authors: S
authors: Ishikawa
authors: Yoshimi
authors: Y
authors: Nakamura
authors: Yuko
authors: Y
authors: Nakamura
authors: Hiroshi
authors: H
authors: Sakai
authors: Shoichi
authors: S
authors: Sawaguchi
authors: Kazuo
authors: K
authors: Terashima
authors: Makoto
authors: M
authors: Kanno
authors: Hidetoshi
authors: H
authors: Yamashita