title: [Efficacy of meloxicam in juvenile polyposis syndrome. A case report].
abstract: The Authors present a case of a 11 year-old patient with a history of Juvenile Polyposis Syndrome (JPS), a condition characterized by the occurrence of multiple hamartomatous polyps in the gastrointestinal tract. Patients with JPS are traditionally treated by repeated endoscopic polypectomies and elective surgery. Recent studies reported up-regulation of cyclo-ossigenase 2 (COX-2) in colorectal polyps. Specific COX-2 inhibitors have been withdrown from the market for tromboembolic side effects. However efficacy and safety of preferential selective COX-2 inhibitor has been reported as antiinflammatory drugs also in children. In this patient meloxicam treatment, a preferential selective COX-2 inhibitor, leaded to a significant reduction in the number of colorectal polyps during 3 years follow up.
authors: Dipartimento di Pediatria, Università di Firenze, Ospedale Meyer, Firenze.
authors: Monica
authors: M
authors: Lorusso
authors: Francesca
authors: F
authors: Mangiantini
authors: Elena
authors: E
authors: Pozzi
authors: Andrea
authors: A
authors: Nucci
authors: Francesca
authors: F
authors: Bronzini
authors: Silvia
authors: S
authors: Bevilacqua
authors: Paolo
authors: P
authors: Lionetti
mesh_terms: D011125:Adenomatous Polyposis Coli / Q000175:diagnosis; D002648:Child; D003111:Colonic Polyps / Q000175:diagnosis* / Q000188:drug therapy*; D016861:Cyclooxygenase Inhibitors / Q000627:therapeutic use*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D000077239:Meloxicam; D013577:Syndrome; D013843:Thiazines / Q000627:therapeutic use*; D013844:Thiazoles / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D016861:Cyclooxygenase Inhibitors; D013843:Thiazines; D013844:Thiazoles; D000077239:Meloxicam