Effect of bergapten from Heracleum nepalense root on production of proinflammatory cytokines.
In the present investigation, the anti-inflammatory activity of isolated bergapten from hydroalcoholic extract of Heracleum nepalense root was evaluated in vitro using human peripheral blood mononuclear cells (PBMCs). Bergapten exhibited significant inhibition of the production of pro-inflammatory cytokines, namely tumour necrotic factor-α (TNF-α) and interleukin-6 (IL-6) by PBMCs stimulated with lipopolysaccharide in a concentration-dependent manner.
Bose
Sekhar K
SK
Division of Pharmacognosy, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India.
Dewanjee
Saikat
S
Sahu
Ranabir
R
Dey
Sankar P
SP
D000078223:5-Methoxypsoralen; D000328:Adult; D018360:Crystallography, X-Ray; D016207:Cytokines / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D030002:Heracleum / Q000737:chemistry*; D006801:Humans; D066298:In Vitro Techniques; D018836:Inflammation Mediators / Q000037:antagonists & inhibitors* / Q000378:metabolism; D008070:Lipopolysaccharides / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008730:Methoxsalen / Q000031:analogs & derivatives* / Q000494:pharmacology; D009000:Monocytes / Q000187:drug effects / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry*; D013055:Spectrophotometry, Infrared
D016207:Cytokines; D018836:Inflammation Mediators; D008070:Lipopolysaccharides; D010936:Plant Extracts; D000078223:5-Methoxypsoralen; D008730:Methoxsalen