title: Gastroesophageal reflux in severe cases of Robin sequence treated with nasopharyngeal intubation.
abstract: OBJECTIVE
  To study the prevalence of abnormal gastroesophageal reflux in infants with Robin sequence who had severe respiratory obstruction treated with nasopharyngeal intubation and to evaluate the efficacy of nonsurgical treatment.
  
  
  METHODS
  Longitudinal prospective study.
  
  
  METHODS
  Hospital de Reabilitação de Anomalias Craniofaciais, University of São Paulo, Brazil.
  
  
  METHODS
  Twenty infants with severe isolated Robin sequence treated with nasopharyngeal intubation.
  
  
  METHODS
  We performed 24-hour esophageal pH monitoring on each child at 2, 4, and 6 months of age. Respiratory and feeding status were evaluated. We considered abnormal gastroesophageal reflux as reflux index values above the 95th percentile of the Vandenplas reference for normal children.
  
  
  RESULTS
  The prevalence of reflux index above the 95th percentile at the first exam was 6/20, a value significantly higher than the reference (5/103, p < .01). At the second and third exams, reflux index values were decreased. Ninety percent of the infants showed improvement of respiratory difficulty and developed oral feeding capacity.
  
  
  CONCLUSIONS
  The prevalence of abnormal gastroesophageal reflux is higher in infants with severe cases of Robin sequence than in normal infants. Nonsurgical procedures improved respiratory and feeding difficulties of most of these infants.
authors: Hospital de Reabilitação de Anomalias Craniofaciais, Universidade de São Paulo, Bauru, Brazil. marquesi@usp.br
authors: Ilza Lazarini
authors: IL
authors: Marques
authors: Luiz Carlos Silveira
authors: LC
authors: Monteiro
authors: Luiz
authors: L
authors: de Souza
authors: Heloísa
authors: H
authors: Bettiol
authors: Catarina Hissako
authors: CH
authors: Sassaki
authors: Renise
authors: R
authors: de Assumpção Costa
mesh_terms: D001938:Brazil / Q000453:epidemiology; D050782:Esophageal pH Monitoring; D005260:Female; D005764:Gastroesophageal Reflux / Q000453:epidemiology / Q000209:etiology* / Q000628:therapy*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007441:Intubation, Gastrointestinal / Q000379:methods*; D008137:Longitudinal Studies; D008297:Male; D010855:Pierre Robin Syndrome / Q000150:complications* / Q000628:therapy*; D015995:Prevalence; D011446:Prospective Studies; D018709:Statistics, Nonparametric