title: [Study on the antitussive and antiasthmatic effects of Radix Fici Hirtae].
abstract: OBJECTIVE
  To observe the antitussive and antiasthmatic effects of Radix Fici Hirtae (RFH).
  
  
  METHODS
  Antitussive effects were observed by ammonia water steaming test in mice and by citric acid test in guinea pigs. Antiasthmatic actions in guinea pigs were observed by histamine and acetylcholine ultrasonic atomization test, involved isolated guinea pig tracheal smoth muscle experiment and anaphylactic shock of guinea pigs.
  
  
  RESULTS
  RFH decreased the frequency of cough induced by ammonia in mice and by citric acid in guinea pig, prolonged the latent period of cough and inhibited the experimental asthma by histamine and acetylcholine solution in conscious guinea pigs, antagonisted the contraction of tracheal smooth muscle by histamine phosphate in guinea pigs and could compete anaphylactic shock in guinea pigs.
  
  
  CONCLUSIONS
  RFH has obvious antitussive and antiasthmatic effects.
authors: College of Chinese Traditional Medicine, Guangzhou University of TCM, Guangzhou 510405, China.
authors: Tian-Nong
authors: TN
authors: Zhou
authors: Li-Hai
authors: LH
authors: Tang
authors: Shi-Chong
authors: SC
authors: Huang
authors: Dan-Dan
authors: DD
authors: Lu
authors: Yan
authors: Y
authors: Wang
authors: Liang-Feng
authors: LF
authors: Liu
authors: Ping
authors: P
authors: Lai
authors: Mu-Rong
authors: MR
authors: Ye
mesh_terms: D000109:Acetylcholine / Q000008:administration & dosage; D000707:Anaphylaxis / Q000139:chemically induced / Q000188:drug therapy; D000818:Animals; D000996:Antitussive Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D001249:Asthma / Q000139:chemically induced / Q000188:drug therapy; D027885:Astragalus propinquus / Q000737:chemistry; D019343:Citric Acid / Q000008:administration & dosage; D003371:Cough / Q000139:chemically induced / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D005100:Expectorants / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006168:Guinea Pigs; D006632:Histamine; D008297:Male; D051379:Mice; D029586:Moraceae / Q000737:chemistry; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D008517:Phytotherapy; D018517:Plant Roots / Q000737:chemistry; D011897:Random Allocation; D014132:Trachea / Q000187:drug effects
chemical_list: D000996:Antitussive Agents; D004365:Drugs, Chinese Herbal; D005100:Expectorants; D019343:Citric Acid; D006632:Histamine; D000109:Acetylcholine