title: Is classic pericentric inversion of chromosome 2 inv(2)(p11q13) associated with an increased risk of unbalanced chromosomes?
abstract: OBJECTIVE
  To study pericentric inversion segregation and interchromosomal effect on sperm for men heterozygous for inv(2)(p11q13), to assess the risk of miscarriage.
  
  
  METHODS
  Case report.
  
  
  METHODS
  Department of reproductive biology, cytogenetics, gynecology, and obstetrics.
  
  
  METHODS
  Seven patients heterozygous for inv(2)(p11q13) and five patients with normal karyotype with experience of recurrent spontaneous miscarriage.
  
  
  METHODS
  Fluorescence in situ hybridization on sperm with 2 p and 2q subtelomeric probes to screen for inversion segregation, and X, Y, and 18 centromeric probes to study interchromosomal effects. One thousand sperm were analyzed per experiment and per patient.
  
  
  METHODS
  Rate of unbalanced chromosomes and aneuploid sperm.
  
  
  RESULTS
  The inv(2)(p11q13) patients showed a 0.3% rate of sperm with unbalanced chromosomes. For interchromosomal effects, a 0.6% aneuploid sperm rate was observed for patients heterozygous for inv(2)(p11q13). This is similar to the 0.5% rate observed for control patients.
  
  
  CONCLUSIONS
  Inv(2)(p11q13) seems not to increase miscarriage for couples with men heterozygous for this inversion.
authors: Department of Reproductive Biology, Cytogenetics, Gynecology, and Obstetrics, Centre Hospitalier Poissy Saint Germain, Poissy, France; EA 2493, UVSQ, Versailles, France.
authors: Fatma
authors: F
authors: Ferfouri
authors: Laboratoire Clement, Le Blanc-Mesnil, France.
authors: Patrice
authors: P
authors: Clement
authors: Department of Reproductive Biology, Cytogenetics, Gynecology, and Obstetrics, Centre Hospitalier Poissy Saint Germain, Poissy, France; EA 2493, UVSQ, Versailles, France.
authors: Denise Molina
authors: DM
authors: Gomes
authors: Laboratoire Clement, Le Blanc-Mesnil, France.
authors: Marie
authors: M
authors: Minz
authors: American Hospital of Paris, Neuilly sur Seine, France.
authors: Edouard
authors: E
authors: Amar
authors: Department of Reproductive Biology, Cytogenetics, Gynecology, and Obstetrics, Centre Hospitalier Poissy Saint Germain, Poissy, France; EA 2493, UVSQ, Versailles, France.
authors: Jacqueline
authors: J
authors: Selva
authors: Department of Reproductive Biology, Cytogenetics, Gynecology, and Obstetrics, Centre Hospitalier Poissy Saint Germain, Poissy, France; EA 2493, UVSQ, Versailles, France. Electronic address: fvialard@hotmail.com.
authors: François
authors: F
authors: Vialard
mesh_terms: D000026:Abortion, Habitual / Q000235:genetics*; D000328:Adult; D016022:Case-Control Studies; D002503:Centromere / Q000235:genetics; D025063:Chromosome Disorders / Q000209:etiology* / Q000235:genetics; D007446:Chromosome Inversion / Q000235:genetics; D002889:Chromosomes, Human, Pair 2; D020732:Cytogenetic Analysis; D005260:Female; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D011247:Pregnancy; D012306:Risk; D055101:Semen Analysis / Q000379:methods