Molecular regulation of hepatic dendritic cell function and its relation to liver transplant outcome.
Studies on liver interstitial dendritic cells (DC) indicate that the maturation and function of these important antigen-presenting cells may be suppressed by continual exposure to microbial products from the gut, in particular, bacterial lipopolysaccharide. New evidence is emerging for a role of specific intracellular regulators of signal transduction and of cytokines in the hepatic microenvironment, which may contribute to a hyporesponsive state in liver DC. Analysis of signaling molecule expression within DC in liver transplant tissue is likely to uncover its relation to allograft outcome.
Sumpter
Tina L
TL
Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
Lunz
John G
JG
Demetris
A Jake
AJ
Thomson
Angus W
AW
D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology*; D004731:Endotoxins / Q000276:immunology; D006085:Graft Survival / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology; D016753:Interleukin-10 / Q000276:immunology; D018664:Interleukin-12 / Q000276:immunology; D008099:Liver / Q000276:immunology*; D016031:Liver Transplantation / Q000276:immunology*; D051379:Mice; D051201:Toll-Like Receptor 10 / Q000276:immunology; D051193:Toll-Like Receptors / Q000276:immunology; D014184:Transplantation, Homologous / Q000276:immunology; D016896:Treatment Outcome
D004731:Endotoxins; C475955:TLR10 protein, human; C539093:Tlr13 protein, mouse; D051201:Toll-Like Receptor 10; D051193:Toll-Like Receptors; D016753:Interleukin-10; D018664:Interleukin-12