title: Glucocorticoid or androgen for autoimmune premature ovary failure in mice.
abstract: OBJECTIVE
  Using mouse autoimmune premature ovary failure (POF) model to seek theoretical evidence for a possible clinical therapy of autoimmune POF with glucocorticoid (GC) or androgen.
  
  
  METHODS
  After autoimmune POF was induced in 60 mice by Pzp3, the mice were randomly assigned into 3 groups (n=20): Two groups were treated with GC or androgen and the control group was treated with distilled water. We observed the changes in the sexual cycles of the mice, the serum level of AzpAb, infiltration of cells positively expressing CD45 in the ovary, and pathological alterations of the ovary.
  
  
  RESULTS
  The sexual cycle of each therapy group was significantly different from that of the control group. The mean serum level of AzpAb of each therapy group was significantly lower than that of the control group, and the mean serum level of AzpAb in the GC group was significantly higher than that of the androgen group. The percentage of growing follicles in the ovary of each therapy group was significantly higher than that of the control group.Ovaries infiltrated by cells positively expressing CD45 of each therapy group were significantly fewer than those of the control group.
  
  
  CONCLUSIONS
  GC or androgen in mice with autoimmune POF could obviously ameliorate the pathogenetic conditions of the disorder, and both treatments have similar therapeutic efficacy.
authors: Department of Gynaecology and Obstetrics, Second Xiangya Hospital, Central South University, Changsha 410011, China.
authors: Xiaobo
authors: X
authors: Shi
authors: Na
authors: N
authors: Li
authors: Can
authors: C
authors: Liao
authors: Qing
authors: Q
authors: Shu
authors: Fufan
authors: F
authors: Zhu
mesh_terms: D000728:Androgens / Q000627:therapeutic use*; D000818:Animals; D001327:Autoimmune Diseases / Q000188:drug therapy*; D004195:Disease Models, Animal; D030762:Estrous Cycle / Q000187:drug effects; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D017493:Leukocyte Common Antigens / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D016649:Primary Ovarian Insufficiency / Q000188:drug therapy* / Q000276:immunology*; D011897:Random Allocation
chemical_list: D000728:Androgens; D005938:Glucocorticoids; D017493:Leukocyte Common Antigens