title: Lesion quantification in oncological positron emission tomography: a maximum likelihood partial volume correction strategy.
abstract: A maximum likelihood (ML) partial volume effect correction (PVEC) strategy for the quantification of uptake and volume of oncological lesions in 18F-FDG positron emission tomography is proposed. The algorithm is based on the application of ML reconstruction on volumetric regional basis functions initially defined on a smooth standard clinical image and iteratively updated in terms of their activity and volume. The volume of interest (VOI) containing a previously detected region is segmented by a k-means algorithm in three regions: A central region surrounded by a partial volume region and a spill-out region. All volume outside the VOI (background with all other structures) is handled as a unique basis function and therefore "frozen" in the reconstruction process except for a gain coefficient. The coefficients of the regional basis functions are iteratively estimated with an attenuation-weighted ordered subset expectation maximization (AWOSEM) algorithm in which a 3D, anisotropic, space variant model of point spread function (PSF) is included for resolution recovery. The reconstruction-segmentation process is iterated until convergence; at each iteration, segmentation is performed on the reconstructed image blurred by the system PSF in order to update the partial volume and spill-out regions. The developed PVEC strategy was tested on sphere phantom studies with activity contrasts of 7.5 and 4 and compared to a conventional recovery coefficient method. Improved volume and activity estimates were obtained with low computational costs, thanks to blur recovery and to a better local approximation to ML convergence.
authors: Department of Bioengineering, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milano, Italy. elisabetta.debernardi@polimi.it
authors: Elisabetta
authors: E
authors: De Bernardi
authors: Elena
authors: E
authors: Faggiano
authors: Felicia
authors: F
authors: Zito
authors: Paolo
authors: P
authors: Gerundini
authors: Giuseppe
authors: G
authors: Baselli
mesh_terms: D000465:Algorithms; D019788:Fluorodeoxyglucose F18; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D016013:Likelihood Functions; D009369:Neoplasms / Q000000981:diagnostic imaging*; D019047:Phantoms, Imaging; D049268:Positron-Emission Tomography / Q000379:methods / Q000706:statistics & numerical data; D011859:Radiography
chemical_list: D019788:Fluorodeoxyglucose F18