Applications of combinatorial chemistry to drug design and development.
This article is a subjective review of the literature from 1998 to April 1999 describing combinatorial chemistry as applied to drug discovery. The first two sections cover proteinase inhibition and small molecule lead discovery for other target classes. The final section describes those combinatorial chemistry-related technologies we think most likely to impact on drug discovery in the future.
Edwards
P J
PJ
Library Design and Production Group, Discovery Chemistry, Pfizer Central Research, Sandwich, Kent CT13 9NJ, UK.
Gardner
M
M
Klute
W
W
Smith
G F
GF
Terrett
N K
NK