Phosphabarrelene-modified Rh-catalysts: a new and selective route towards hydroxy-functionalized bicyclic imidazoles via tandem reactions.
8-Hydroxy-6-methyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine was formed selectively in high yields from N-(beta-methallyl)imidazole by a tandem hydroformylation-cyclization sequence, representing a novel one-pot catalytic synthesis of bicyclic imidazole derivatives.
Bäuerlein
Patrick S
PS
Schuit Institute of Catalysis, Laboratory for Homogeneous Catalysis, Eindhoven University of Technology, 5600 MB Eindhoven, The Netherlands.
Gonzalez
Ismael Arenas
IA
Weemers
Jarno J M
JJ
Lutz
Martin
M
Spek
Anthony L
AL
Vogt
Dieter
D
Müller
Christian
C
D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D018360:Crystallography, X-Ray; D003500:Cyclization; D007093:Imidazoles / Q000138:chemical synthesis / Q000737:chemistry*; D008968:Molecular Conformation; D011725:Pyridines / Q000138:chemical synthesis / Q000737:chemistry*; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism
C544488:8-hydroxy-6-methyl-5,6,7,8-tetrahydroimidazo(1,2-a)pyridine; D001643:Bridged Bicyclo Compounds; D007093:Imidazoles; D011725:Pyridines; D012238:Rhodium