[Study on chemical constituents from roots of Saussurea lappa].
OBJECTIVE
To study the chemical constituents in roots of Saussurea lappa.


METHODS
Isolation and purification were carried out by silica gel, Sephadex LH-20 and RP-18 column chromatography. The chemical structures of constituents were elucidated on the basis of spectral data.


RESULTS
Eleven compounds were isolated and identified as: 5,7-dihydroxy-2-methylchromone (1), p-hydroxybenzaldehyde (2), 3,5-dimethoxy-4-hydroxy-benzaldehyde (3), 3,5-dimethoxy-4-hydroxy-acetophenone (4), ethyl 2-pyrrolidinone-5(s)-carboxylate (5), 5-hydroxymethyl-furaldehyde (6), palmitic acid (7), succinic acid (8), glucose (9), daucosterol (10), beta-sitosterol (11).


CONCLUSIONS
Compounds 1, 2, 4, 5, 7, 9 were isolated from the genus Saussurea for the first time.
Zhang
Ting
T
Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Wang
Hongqing
H
Du
Guanhua
G
Chen
Ruoyun
R
D001547:Benzaldehydes / Q000737:chemistry* / Q000302:isolation & purification; D019308:Palmitic Acid / Q000737:chemistry / Q000302:isolation & purification; D018517:Plant Roots / Q000737:chemistry*; D011760:Pyrrolidinones / Q000737:chemistry / Q000302:isolation & purification; D030441:Saussurea / Q000737:chemistry*; D012855:Sitosterols / Q000737:chemistry* / Q000302:isolation & purification
D001547:Benzaldehydes; D011760:Pyrrolidinones; D012855:Sitosterols; D019308:Palmitic Acid; C025473:gamma-sitosterol; C028537:2-pyrrolidone; C011483:4-hydroxybenzaldehyde; C011015:lyoniside