title: Pregnancy outcomes in diabetes subtypes: how do they compare? A province-based study of Ontario, 2005-2006.
abstract: OBJECTIVE
  To ascertain differences in pregnancy outcomes between women with diabetes subtypes (type 1 [DM1], type 2 [DM2], women with gestational [GDM])] and non-diabetic women within a large Canadian population.
  
  
  METHODS
  We performed a retrospective multi-cohort analysis of all obstetrical deliveries that occurred in the province of Ontario between April 1, 2005, and March 31, 2006. Data were extracted from the Ontario Niday Perinatal Database.
  
  
  RESULTS
  Increased rates of major negative maternal and perinatal outcomes (i.e. preterm delivery, Caesarean section, pregnancy-induced hypertension/preeclampsia) occurred in women with DM1. Both DM1 and GDM subtypes were associated with the greatest risk of macrosomia, shoulder dystocia, and congenital anomalies. DM2 did not demonstrate an association with an increased risk of congenital malformations and stillbirth.
  
  
  CONCLUSIONS
  Diabetes in pregnancy, irrespective of subtype, predisposes women to poorer outcomes than those of the general obstetric population. However, this large population analysis is consistent with previous studies in showing that the adversity remains greatest for women with type 1 diabetes.
authors: Department of Medicine, The Ottawa Hospital, Ottawa ON.
authors: Patricia
authors: P
authors: Peticca
authors: Department of Medicine, The Ottawa Hospital, Ottawa ON; Department of Obstetrics and Gynecology, The Ottawa Hospital, Ottawa ON.
authors: Erin J
authors: EJ
authors: Keely
authors: Department of Obstetrics and Gynecology, The Ottawa Hospital, Ottawa ON; Ottawa Hospital Research Institute, Ottawa ON.
authors: Mark C
authors: MC
authors: Walker
authors: Department of Obstetrics and Gynecology, The Ottawa Hospital, Ottawa ON; Ottawa Hospital Research Institute, Ottawa ON.
authors: Qiuying
authors: Q
authors: Yang
authors: The Ontario Perinatal Surveillance System, Ottawa ON.
authors: Jim
authors: J
authors: Bottomley
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D015331:Cohort Studies; D016640:Diabetes, Gestational / Q000453:epidemiology*; D005260:Female; D006801:Humans; D009864:Ontario / Q000453:epidemiology; D011247:Pregnancy; D011256:Pregnancy Outcome; D011254:Pregnancy in Diabetics / Q000453:epidemiology*; D012189:Retrospective Studies