title: Recent developments in the pathology of renal tumors: morphology and molecular characteristics of select entities.
abstract: BACKGROUND
  Renal cell carcinoma is a heterogeneous group of tumors with distinct histopathologic features, molecular characteristics, and clinical outcome. These tumors can be sporadic as well as familial or associated with syndromes. The genetic abnormalities underlying these syndromes have been identified and were subsequently found in corresponding sporadic renal tumors.
  
  
  OBJECTIVE
  To review the recent molecular and genetic advancements relating to sporadic and familial renal carcinomas as well as those related to Xp11.2 translocation-associated renal cell carcinoma and renal medullary carcinoma.
  
  
  METHODS
  Literature review, personal experience, and material from the University of Chicago.
  
  
  CONCLUSIONS
  Molecular genetic diagnostic techniques will continue to introduce new biomarkers that will aid in the differential diagnosis of difficult cases. The identification of specific signaling pathways that are defective in certain renal tumors also makes possible the development of new therapies that selectively target the aberrant activity of the defective proteins.
authors: Department of Pathology, University of Chicago, Chicago, Illinois, USA.
authors: Benjamin C
authors: BC
authors: Yan
authors: A Craig
authors: AC
authors: Mackinnon
authors: Hikmat A
authors: HA
authors: Al-Ahmadie
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics; D002292:Carcinoma, Renal Cell / Q000175:diagnosis / Q000235:genetics / Q000473:pathology*; D041321:Chromosomes, Human, X / Q000235:genetics; D003937:Diagnosis, Differential; D006801:Humans; D007680:Kidney Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000473:pathology*; D010340:Pathology, Surgical / Q000639:trends*; D014178:Translocation, Genetic / Q000235:genetics
chemical_list: D014408:Biomarkers, Tumor