Tangled up in red: intertwining of the heme and iron-sulfur cluster biogenesis pathways.
A large-scale computational and genetic analysis study by Nilsson et al. (2009) has identified five genes that coexpress with heme biosynthetic enzymes and are required for normal heme synthesis. Several are implicated in iron-sulfur cluster biogenesis, and malfunction of these genes may repress heme synthesis by activating the IRE/IRP posttranscriptional regulatory system.
Rouault
Tracey A
TA
Molecular Medicine Program, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA. trou@helix.nih.gov
Tong
Wing-Hang
WH
D000818:Animals; D006418:Heme / Q000096:biosynthesis* / Q000378:metabolism; D006801:Humans; D035925:Iron-Regulatory Proteins / Q000378:metabolism; D007506:Iron-Sulfur Proteins / Q000378:metabolism*; D033681:Mitochondrial Membrane Transport Proteins / Q000235:genetics / Q000378:metabolism; D005810:Multigene Family; D015027:Zebrafish
D035925:Iron-Regulatory Proteins; D007506:Iron-Sulfur Proteins; D033681:Mitochondrial Membrane Transport Proteins; D006418:Heme