title: [Use of fibrin glue in ocular surgery].
abstract: OBJECTIVE
  To evaluate the use of fibrin glue and its complications in different ophthalmic surgeries.
  
  
  METHODS
  A retrospective and non-comparative case series study. 161 eyes were evaluated. The mean age was 51.8 years. Fibrin glue (Beriplast--Aventis Behring, Germany) was used in all patients for tissue adherence or incisional closure.
  
  
  RESULTS
  Main preoperatives diseases were pterygium (76 patients), superior limbic keratoconjunctivitis (4 patients), limbal tumor (4 patients), conjunctivochalasis (21 patients), bullous keratopathy (31 patients), limbal stem cell deficiency (7 patients), alkali injury (6 patients), Stevens-Johnson syndrome (2 patients), cataract (5 patients) and glaucoma (5 patients). Complications occurred in 28 patients (17.4%). Detachment of the fixed tissue and granulomatous foreign body reaction were the main complications. Detachment occurred in 10 cases (5.6%) (7 in amniotic membrane transplantation in bullous keratopathy, 2 in autologous conjunctival grafting for pterygium surgery, 1 in autologous limbal transplantation in a Stevens-Johnson syndrome). Granulomatous foreign body reaction was described in 9 patients (5.6%) (5 in amniotic membrane transplantation due to acute alkali injury, 1 in autologous limbal graft due to chronic burn injury, and 3 in autologous conjunctival transplant due to pterygium surgery). All the complications described occurred in the first week after surgery.
  
  
  CONCLUSIONS
  Despite the limitations related to the retrospective and non-comparative setting, this study suggests that the use of fibrin glue seems to be safe and effective for tissue fixation or incisional closure presenting low rates of complications in ocular surface and anterior segment surgeries.
authors: Setor de Córnea e Doenças Externas, Serviço de Oftalmologia, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brasil.
authors: Melissa Manfroi
authors: MM
authors: Dal Pizzol
authors: Murilo Felix
authors: MF
authors: Roggia
authors: Sérgio
authors: S
authors: Kwitko
authors: Diane Ruschel
authors: DR
authors: Marinho
authors: Samuel
authors: S
authors: Rymer
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001938:Brazil; D002648:Child; D002675:Child, Preschool; D005128:Eye Diseases / Q000145:classification / Q000601:surgery*; D015718:Fibrin Tissue Adhesive / Q000009:adverse effects* / Q000627:therapeutic use; D015745:Granuloma, Foreign-Body / Q000139:chemically induced; D006801:Humans; D008875:Middle Aged; D013508:Ophthalmologic Surgical Procedures / Q000145:classification / Q000379:methods; D012189:Retrospective Studies; D013997:Time Factors; D014014:Tissue Adhesives / Q000009:adverse effects* / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D015718:Fibrin Tissue Adhesive; D014014:Tissue Adhesives