COMT val(158)met genotype and smooth pursuit eye movements in schizophrenia.
The association between the catechol-O-methyltransferase (COMT) val(158)met polymorphism (rs4680) and smooth pursuit eye movements (SPEM) was investigated in 110 schizophrenia patients and 96 controls. Patients had lower steady-state pursuit gain and made more frequent saccades than controls. Genotype was not associated with schizophrenia or SPEM, in either group or the combined sample. SPEM deficits in schizophrenia appear to be determined by genotypes other than rs4680, although the study may have lacked power to detect small effects.
Haraldsson
H Magnus
HM
Division of Psychiatry, Landspitali-University Hospital, Reykjavik, Iceland. hmagnus@landspitali.is
Ettinger
Ulrich
U
Magnusdottir
Brynja B
BB
Sigmundsson
Thordur
T
Sigurdsson
Engilbert
E
Ingason
Andres
A
Petursson
Hannes
H
D000328:Adult; D000704:Analysis of Variance; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D004252:DNA Mutational Analysis; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008715:Methionine / Q000235:genetics*; D008875:Middle Aged; D009483:Neuropsychological Tests; D015835:Ocular Motility Disorders / Q000209:etiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011569:Psychiatric Status Rating Scales; D011698:Pursuit, Smooth / Q000235:genetics*; D011930:Reaction Time; D012559:Schizophrenia / Q000150:complications / Q000235:genetics; D014633:Valine / Q000378:metabolism*
D008715:Methionine; D002394:Catechol O-Methyltransferase; D014633:Valine