title: Femtosecond-assisted lamellar keratoplasty in atypical Avellino corneal dystrophy of Indian origin.
abstract: OBJECTIVE
  To report a case of Avellino corneal dystrophy (ACD) in a patient of Indian origin treated with femtosecond-assisted lamellar keratoplasty (FALK).
  
  
  METHODS
  A 6-year-old male patient presented with severe photophobia with decreased vision for 2 months. A clinical diagnosis of Avellino dystrophy was made after complete examination under anesthesia and FALK was performed.
  
  
  RESULTS
  The postoperative period was uneventful with good symptomatic improvement and graft clarity. Histopathological study with special staining, namely Masson trichrome and Congo red stain, of the patient's corneal button showed features of both granular and lattice lesions suggestive of ACD. Genetic analysis showed absence of R124H mutation in BIGH3 gene. No recurrence or exacerbation was noted at 19-month follow-up.
  
  
  CONCLUSIONS
  To our knowledge, this is the first case report of clinical, histopathological, microscopic features of ACD in young patient of Indian origin with absence of BIGH3 gene treated with FALK with IntraLase Femtosecond Laser for donor and recipient cuts.
authors: Department of Ophthalmology, Eye Research Centre and Dr. Agarwal's Group of Eye Hospitals, Chennai, India. dragarwal@vsnl.com
authors: Amar
authors: A
authors: Agarwal
authors: Jacob W
authors: JW
authors: Brubaker
authors: Nick
authors: N
authors: Mamalis
authors: Dhivya Ashok
authors: DA
authors: Kumar
authors: Soosan
authors: S
authors: Jacob
authors: Sujatha
authors: S
authors: Chinnamuthu
authors: Vidya
authors: V
authors: Nair
authors: Gaurav
authors: G
authors: Prakash
authors: Alessandro
authors: A
authors: Meduri
authors: Athiya
authors: A
authors: Agarwal
mesh_terms: D044466:Asian People; D002648:Child; D003315:Cornea / Q000473:pathology; D003317:Corneal Dystrophies, Hereditary / Q000150:complications / Q000208:ethnology / Q000473:pathology* / Q000601:surgery*; D016039:Corneal Transplantation / Q000379:methods*; D016326:Extracellular Matrix Proteins / Q000235:genetics; D006801:Humans; D007194:India; D053685:Laser Therapy / Q000379:methods*; D008297:Male; D009154:Mutation; D020795:Photophobia / Q000209:etiology; D012720:Severity of Illness Index; D016212:Transforming Growth Factor beta / Q000235:genetics; D014786:Vision Disorders / Q000209:etiology; D000099222:betaIG-H3 Protein
chemical_list: D016326:Extracellular Matrix Proteins; D016212:Transforming Growth Factor beta; D000099222:betaIG-H3 Protein