Primary myelodysplastic syndrome in Jordan: a single-centre experience.
OBJECTIVE
Study of the disease patterns and clinical evaluation of myelodysplastic syndrome (MDS).


METHODS
A retrospective analysis was carried out on 85 patients, with MDS who were followed up over a period of 23 years at Jordan University Hospital, Amman, Jordan. Cases were analyzed according to the French, American and British Classification.


RESULTS
Of the 85 patients, 42 (49.4%) were females and 43 (50%) males; mean age was 59 +/- 19 years (range 18-88). Most subtypes found in patients were refractory anemia (RA) in 27 (31.8%) and RA with excess blasts (RAEB) in 28 (32.9%). Adverse prognostic indicators were RAEB subtype and requirement for blood transfusion.


CONCLUSIONS
Our findings showed that MDSs appeared at a younger age and tended to be of the aggressive subtype. Chronic myelomonocytic leukemia subtype seemed to appear dominantly in men.
Awidi
Abdalla
A
Department of Hematology and Oncology, Jordan University Hospital, Amman, Jordan. aawidi@yahoo.com
Magableh
Ahmad
A
Taimeh
Ziad
Z
Ayyad
Hashim
H
Bsoul
Nazzal
N
Tarawneh
Musleh
M
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D000754:Anemia, Refractory, with Excess of Blasts / Q000453:epidemiology / Q000503:physiopathology*; D000756:Anemia, Sideroblastic / Q000453:epidemiology / Q000503:physiopathology*; D003906:Developing Countries; D018450:Disease Progression; D005260:Female; D006785:Hospitals, University; D006801:Humans; D007597:Jordan / Q000453:epidemiology; D053208:Kaplan-Meier Estimate; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000453:epidemiology / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D017678:Sex Distribution; D055815:Young Adult