Sixty-two cases of intractable ascites due to cirrhosis treated by the modified Wulingsan power plus abdominal reinfusion of the concentrated ascites after ultrafiltration.
OBJECTIVE
To observe the clinical therapeutic effects of Wulingsan Jiawei ([Chinese characters: see text] Supplemented Powder of Five Drugs with Poria, SPFDP) plus abdominal reinfusion of concentrated ascites after ultrafiltration (ARCAU) for intractable ascites due to cirrhosis (IAC).


METHODS
124 cases of IAC were randomly divided into two groups, a treatment group of 62 cases treated by oral administration of SPFDP plus ARCAU and a control group of 62 cases treated simply by ARCAU. Aldosterone (ALD) level in plasma, levels of total bilirubin (TBIL) and albumin (ALB) in serum, and activity of alanine aminotransferase (ALT) were determined in the two groups before and after treatment.


RESULTS
After treatment ALT activity and TBIL level in the treatment group were significantly lower than those in the control group, and ALB content in the treatment group was significantly higher than that in the control group. ALD level of the treatment group significantly decreased after treatment as compared with that before treatment, while that of the control group did not decreased significantly after treatment. The treatment group was significantly superior in keeping down ascites to the control group.


CONCLUSIONS
SPFDP plus ARCAU treatment of IAC can markedly raise the clinical therapeutic effect, reduce recurrence of ascites, and improve the liver function, which can produce a significant decrease in ALD level in plasma and a marked increase in ALB content.
Zhao
He-ping
HP
No.150 Central Hospital of PLA, Luoyang 471031, China.
Zhang
Zi-ran
ZR
Ding
Bao-hua
BH
Guo
Shi-min
SM
Zhao
Yao-zhou
YZ
Dong
Shu-na
SN
D000328:Adult; D001201:Ascites / Q000188:drug therapy* / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D010936:Plant Extracts / Q000627:therapeutic use*; D016896:Treatment Outcome; D014462:Ultrafiltration / Q000379:methods*
D010936:Plant Extracts; C443861:wulingsan