[Rosuvastatin attenuates vascular endothelial adhesiveness in apolipoprotein E-deficient mice].
OBJECTIVE
To investigate the anti-inflammatory effects on the vessel wall of rosuvastatin in apolipoprotein E-deficient mice.


METHODS
Eight-week-old apolipoprotein E-deficient mice fed a normal chow diet were treated with vehicle or various doses of rosuvastatin (1, 5, or 20 mg/kg) by subcutaneous injection for 2 or 6 weeks prior to sacrifice. Endothelial adhesiveness for monocytes was determined by functional binding assay. The expressions of vascular cell adhesion molecule-1 and monocyte chemotactic protein-1 in the vessel wall were detected by quantitative real-time polymerase chain reaction.


RESULTS
Endothelial adhesiveness for monocytes was significantly attenuated after 2 or 6 weeks treatments with 5 or 20 mg/kg rosuvastatin. Rosuvastatin also significantly reduced the expressions of vascular cell adhesion molecule-1 and monocyte chemotactic protein-1 in the vessel wall.


CONCLUSIONS
The anti-inflammatory effects of suvastatin might be responsible for attenuating the pathogenesis of atherogenesis in apolipoprotein E-deficient mice.
Li
Wei
W
Department of Geriatrics, Hainan Provincial People's Hospital, Haikou 570311, China.
Huang
Hai-ying
HY
Wu
Zhi-yong
ZY
Xie
Fang-qiu
FQ
Zhang
Xu-ri
XR
Guan
Pin
P
D000818:Animals; D001057:Apolipoproteins E / Q000235:genetics*; D002448:Cell Adhesion / Q000187:drug effects*; D004730:Endothelium, Vascular / Q000166:cytology; D005464:Fluorobenzenes / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009000:Monocytes / Q000187:drug effects* / Q000378:metabolism; D011743:Pyrimidines / Q000494:pharmacology*; D000068718:Rosuvastatin Calcium; D013449:Sulfonamides / Q000494:pharmacology*; D019010:Vascular Cell Adhesion Molecule-1 / Q000378:metabolism*
D001057:Apolipoproteins E; D005464:Fluorobenzenes; D011743:Pyrimidines; D013449:Sulfonamides; D019010:Vascular Cell Adhesion Molecule-1; D000068718:Rosuvastatin Calcium