Genetic properties of the maize nested association mapping population.
Maize genetic diversity has been used to understand the molecular basis of phenotypic variation and to improve agricultural efficiency and sustainability. We crossed 25 diverse inbred maize lines to the B73 reference line, capturing a total of 136,000 recombination events. Variation for recombination frequencies was observed among families, influenced by local (cis) genetic variation. We identified evidence for numerous minor single-locus effects but little two-locus linkage disequilibrium or segregation distortion, which indicated a limited role for genes with large effects and epistatic interactions on fitness. We observed excess residual heterozygosity in pericentromeric regions, which suggested that selection in inbred lines has been less efficient in these regions because of reduced recombination frequency. This implies that pericentromeric regions may contribute disproportionally to heterosis.
McMullen
Michael D
MD
United States Department of Agriculture-Agriculture Research Service (USDA-ARS), USA. mcmullenm@missouri.edu
Kresovich
Stephen
S
Villeda
Hector Sanchez
HS
Bradbury
Peter
P
Li
Huihui
H
Sun
Qi
Q
Flint-Garcia
Sherry
S
Thornsberry
Jeffry
J
Acharya
Charlotte
C
Bottoms
Christopher
C
Brown
Patrick
P
Browne
Chris
C
Eller
Magen
M
Guill
Kate
K
Harjes
Carlos
C
Kroon
Dallas
D
Lepak
Nick
N
Mitchell
Sharon E
SE
Peterson
Brooke
B
Pressoir
Gael
G
Romero
Susan
S
Oropeza Rosas
Marco
M
Salvo
Stella
S
Yates
Heather
H
Hanson
Mark
M
Jones
Elizabeth
E
Smith
Stephen
S
Glaubitz
Jeffrey C
JC
Goodman
Major
M
Ware
Doreen
D
Holland
James B
JB
Buckler
Edward S
ES
D000483:Alleles; D002503:Centromere / Q000235:genetics; D002874:Chromosome Mapping; D032461:Chromosomes, Plant / Q000235:genetics*; D003433:Crosses, Genetic; D004843:Epistasis, Genetic; D035264:Flowers / Q000235:genetics / Q000254:growth & development; D014644:Genetic Variation; D018745:Genome, Plant; D006579:Heterozygote; D006823:Hybrid Vigor; D007178:Inbreeding; D015810:Linkage Disequilibrium; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D040641:Quantitative Trait Loci; D019655:Quantitative Trait, Heritable; D011995:Recombination, Genetic; D012641:Selection, Genetic; D003313:Zea mays / Q000145:classification / Q000235:genetics* / Q000502:physiology