title: Commentary on the WHO classification of tumors of lymphoid tissues (2008): aggressive B-cell lymphomas.
abstract: In the novel WHO classification 2008, the classification of aggressive B-cell lymphoma has been revised for several categories with the aim to define "clean" entities. Within large B-cell lymphoma, a few distinct clinico-pathological entities have been recognized with more clinically defined entities than pathologically defined ones. The majority of known morphological variations were not considered to merit more than classification as a variant of DLBCL, not otherwise specified. Specifically, a biological subgrouping of DLBCL on the basis of molecular (activated B-cell versus germinal center B-cell) or immunophenotypic (CD5+) features was felt to be too immature to include at this stage. The role of EBV in aggressive B-cell lymphoma has been explored in more depth with the recognition of several novel and re-defined clinico-pathological entities. Also, in these diseases, clinical definitions play a very dominant role in the WHO classification 2008.
authors: Olga
authors: O
authors: Balague Ponz
authors: German
authors: G
authors: Ott
authors: Robert P
authors: RP
authors: Hasserjian
authors: Kojo S J
authors: KS
authors: Elenitoba-Johnson
authors: Laurence
authors: L
authors: de Leval
authors: Daphne
authors: D
authors: de Jong