title: Skeletal effects of whole-body vibration in adult and aged mice.
abstract: Low-amplitude, whole-body vibration (WBV) may be anabolic for bone. Animal studies of WBV have not evaluated skeletal effects in aged animals. We exposed 75 male BALB/c mice (7 month/young-adult; 22 month/aged) to 5 weeks of daily WBV (15 min/day, 5 day/wk; 90 Hz sine wave) at acceleration amplitudes of 0 (sham), 0.3, or 1.0 g. Whole-body bone mineral content (BMC) increased with time in 7 month (p < 0.001) but not 22 month (p = 0.34) mice, independent of WBV (p = 0.60). In 7 month mice, lower-leg BMC increased with time in 0.3 and 1.0 g groups (p < 0.005) but not in the sham group (p = 0.09), indicating a positive WBV effect. In 22 month mice, there were no changes with time in lower-leg BMC (p = 0.11). WBV did not affect tibial trabecular or cortical bone structure (by microCT), dynamic indices of trabecular or cortical bone formation, trabecular osteoclast surface, or the mass of the reproductive fat pad (p > 0.05). Each of these outcomes was diminished in 7 month versus 22 month animals (p < 0.05). In summary, 5 weeks of daily exposure to low-amplitude WBV had no skeletal effects in aged male mice. The potential of WBV to enhance bone mass in age-related osteoporosis is not supported in this preclinical study.
authors: Department of Orthopaedic Surgery, Washington University, St. Louis, Missouri 63110, USA.
authors: Michelle A
authors: MA
authors: Lynch
authors: Michael D
authors: MD
authors: Brodt
authors: Matthew J
authors: MJ
authors: Silva
mesh_terms: D000222:Adaptation, Physiological; D000367:Age Factors; D000375:Aging / Q000502:physiology*; D000818:Animals; D015519:Bone Density; D001842:Bone and Bones / Q000503:physiopathology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010024:Osteoporosis / Q000503:physiopathology* / Q000517:prevention & control; D013312:Stress, Physiological; D014732:Vibration