title: Clinicopathological factors associated with clinical outcomes of endoscopic submucosal dissection for colorectal epithelial neoplasms.
abstract: OBJECTIVE
  Endoscopic submucosal dissection (ESD) permits removal of colorectal epithelial neoplasms en bloc, but a substantial risk of procedure-related perforation has been reported. We sought to unravel the clinicopathological factors associated with the clinical outcomes of ESD for colorectal epithelial neoplasms in a large series.
  
  
  METHODS
  ESD was done in 278 patients with 292 colorectal tumors that fulfilled the inclusion criteria. The criteria for ESD were: lesion greater than 20 mm in size, lesion with fibrotic scarring, locally residual colorectal lesion, or invasive carcinoma with slight submucosal penetration. Resection was assessed as en bloc or piecemeal, complete (en bloc with tumor-free lateral and basal margins) or incomplete. Complications including perforation and bleeding were assessed, and factors related to each were analyzed using logistic regression. Patients underwent multiple follow-up endoscopic examinations (mean 4.6; median 4; range 2 - 9; total number 1010).
  
  
  RESULTS
  En bloc resection was achieved in 90.1 % of lesions (263/292) and resection was deemed to be complete in 233 (79.8 %). Right-side colonic location and the finding of fibrosis were the significant contributors to incomplete resection. Perforation was seen in 24 cases (8.2 %), and was associated with large tumor size and the presence of fibrosis. When the contributive factors for each were combined, the risks of incomplete resection and perforation were substantially increased.
  
  
  CONCLUSIONS
  The present study provides useful information for predicting risks for incomplete resection and complication in colorectal ESD.
authors: Department of Endoscopy, Nagasaki University Hospital, Sakamoto, Nagasaki, Japan. hajimei2002@yahoo.co.jp
authors: H
authors: H
authors: Isomoto
authors: H
authors: H
authors: Nishiyama
authors: N
authors: N
authors: Yamaguchi
authors: E
authors: E
authors: Fukuda
authors: H
authors: H
authors: Ishii
authors: K
authors: K
authors: Ikeda
authors: K
authors: K
authors: Ohnita
authors: K
authors: K
authors: Nakao
authors: S
authors: S
authors: Kohno
authors: S
authors: S
authors: Shikuwa
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016009:Chi-Square Distribution; D015179:Colorectal Neoplasms / Q000473:pathology / Q000601:surgery*; D004210:Dissection; D004945:Esophagoscopy / Q000009:adverse effects*; D005260:Female; D005355:Fibrosis; D006471:Gastrointestinal Hemorrhage / Q000209:etiology; D006801:Humans; D007416:Intestinal Perforation / Q000209:etiology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009092:Mucous Membrane / Q000473:pathology / Q000601:surgery*; D009361:Neoplasm Invasiveness; D009375:Neoplasms, Glandular and Epithelial / Q000473:pathology / Q000601:surgery*; D012307:Risk Factors; D018709:Statistics, Nonparametric; D016896:Treatment Outcome