title: Evaluation of two novel aluminum-free, zinc-based glass polyalkenoate cements as alternatives to PMMA bone cement for use in vertebroplasty and balloon kyphoplasty.
abstract: Vertebroplasty (VP) and balloon kyphoplasty (BKP) are now widely used for treating patients in whom the pain due to vertebral compression fractures is severe and has proved to be refractory to conservative treatment. These procedures involve percutaneous delivery of a bolus of an injectable bone cement either directly to the fractured vertebral body, VB (VP) or to a void created in it by an inflatable bone tamp (BKP). Thus, the cement is a vital component of both procedures. In the vast majority of VPs and BKPs, a poly(methyl methacrylate) (PMMA) bone cement is used. This material has many shortcomings, notably lack of bioactivity and very limited resorbability. Thus, there is room for alternative cements. We report here on two variants of a novel, bioactive, Al-free, Zn-based glass polyalkenoate cement (Zn-GPC), and how their properties compare to those of an injectable PMMA bone cement (SIMPL) that is widely used in VP and BKP. The properties determined were injectability, radiopacity, uniaxial compressive strength, and biaxial flexural modulus. In addition, we compared the compression fatigue lives of a validated synthetic osteoporotic VB model (a polyurethane foam cube with an 8 mm-diameter through-thickness cylindrical hole), at 0-2300 N and 3 Hz, when the hole was filled with each of the three cements. A critical review of the results suggests that the performance of each of the Zn-GPCs is comparable to that of SIMPL; thus, the former cements merit further study with a view to being alternatives to an injectable PMMA cement for use in VP and BKP.
authors: Department of Mechanical Engineering, The University of Memphis, Memphis, TN 38152, USA. glewis@memphis.edu
authors: Gladius
authors: G
authors: Lewis
authors: Mark R
authors: MR
authors: Towler
authors: Daniel
authors: D
authors: Boyd
authors: Matthew J
authors: MJ
authors: German
authors: Anthony W
authors: AW
authors: Wren
authors: Owen M
authors: OM
authors: Clarkin
authors: Andrew
authors: A
authors: Yates
mesh_terms: D000535:Aluminum / Q000737:chemistry; D001843:Bone Cements / Q000737:chemistry / Q000627:therapeutic use; D019245:Compressive Strength; D005899:Glass Ionomer Cements / Q000737:chemistry* / Q000627:therapeutic use*; D006801:Humans; D007267:Injections; D008422:Materials Testing; D008961:Models, Structural; D010024:Osteoporosis / Q000473:pathology; D018583:Pliability / Q000502:physiology; D019904:Polymethyl Methacrylate / Q000737:chemistry*; D054854:Vertebroplasty / Q000295:instrumentation / Q000379:methods*; D015032:Zinc / Q000737:chemistry*
chemical_list: D001843:Bone Cements; D005899:Glass Ionomer Cements; D019904:Polymethyl Methacrylate; D000535:Aluminum; D015032:Zinc