[Expression pattern of MAL in normal epithelial cells, benign tumor, and squamous cell carcinoma of larynx].
OBJECTIVE
To compare the expression pattern of the MAL protein in normal and laryngeal carcinoma to derive possible implications of MAL in carcinoma development of larynx.


METHODS
Use the immunohistochemical technique to analyze the distribution of MAL in normal laryngeal epithelial cells, polyp of vocal cords, laryngeal atypical hyperplasia and laryngeal squamous cell carcinoma.


RESULTS
MAL-like immunohistochemical reactions are strongly expressed in normal laryngeal epithelial cells and its expression is no significantly different in epithelial cells of the polyp of vocal cords. Comparatively, MAL expression is significantly down regulated in laryngeal atypical hyperplasia and laryngeal squamous cell carcinomas (P < 0.05).


CONCLUSIONS
MAL is normally expressed in laryngeal epithelial cells and its expression changes at early stages of carcinoma development. MAL, therefore, is a potential marker for early diagnosis of laryngeal squamous cell carcinoma.
Jiang
Yi
Y
Department of Otorhinolaryngology, Fujian Provincial Hospital, Fuzhou, 350001, China. dr.jiangyi@163.com
Chen
Yong
Y
Gao
Lingyun
L
Ye
Qing
Q
Alonso
M A
MA
D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D016022:Case-Control Studies; D004311:Double-Blind Method; D004847:Epithelial Cells / Q000378:metabolism; D006801:Humans; D007820:Laryngeal Mucosa / Q000166:cytology / Q000378:metabolism*; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D026901:Membrane Transport Proteins / Q000378:metabolism*; D009185:Myelin Proteins / Q000378:metabolism*; D062806:Myelin and Lymphocyte-Associated Proteolipid Proteins; D011510:Proteolipids / Q000378:metabolism*
C569026:MAL protein, human; D026901:Membrane Transport Proteins; D009185:Myelin Proteins; D062806:Myelin and Lymphocyte-Associated Proteolipid Proteins; D011510:Proteolipids