title: Rhodium catalyzed enantioselective cyclization of substituted imidazoles via C-H bond activation.
abstract: The enantioselective intramolecular alkylation of substituted imidazoles with enantiomeric excesses up to 98% has been accomplished by rhodium catalyzed C-H bond functionalization with (S,S',R,R')TangPhos as the chiral ligand.
authors: Department of Chemistry, University of California, Berkeley, CA 94720-1460, USA.
authors: Andy S
authors: AS
authors: Tsai
authors: Rebecca M
authors: RM
authors: Wilson
authors: Hitoshi
authors: H
authors: Harada
authors: Robert G
authors: RG
authors: Bergman
authors: Jonathan A
authors: JA
authors: Ellman
mesh_terms: D002384:Catalysis; D003500:Cyclization; D007093:Imidazoles / Q000737:chemistry* / Q000378:metabolism*; D012238:Rhodium / Q000494:pharmacology*
chemical_list: D007093:Imidazoles; D012238:Rhodium