[Carcinogenic hazard of chloroform and other drinking water chlorination by-products].
The paper presents the results of studying the carcinogenic effect of chloroform and its combination with carbon tetrachloride, 1,2-dichloroethane, trichloroethylene during chronic oral administration to F1(CBAxC57Bl6) mice. There is a relationship between the manifestation of carcinogenesis to the dose of chloroform and a combination of chemicals, as well as its enhancement upon exposure to the combination as compared with acute administration of chloroform. Exposure to a combination of substances at the level of their maximum permissible concentrations does not affect carcinogenesis. The possible mechanisms of the specific features of carcinogenesis in this experiment are discussed.
Chernichenko
I A
IA
Balenko
N V
NV
Litvichenko
O N
ON
D000818:Animals; D002251:Carbon Tetrachloride / Q000032:analysis / Q000633:toxicity*; D015197:Carcinogenicity Tests; D002725:Chloroform / Q000032:analysis / Q000633:toxicity*; D005025:Ethylene Dichlorides / Q000032:analysis / Q000633:toxicity*; D005260:Female; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009374:Neoplasms, Experimental / Q000139:chemically induced* / Q000473:pathology; D014241:Trichloroethylene / Q000032:analysis / Q000633:toxicity*; D014874:Water Pollutants, Chemical / Q000737:chemistry / Q000633:toxicity*
D005025:Ethylene Dichlorides; D014874:Water Pollutants, Chemical; D014241:Trichloroethylene; C024565:ethylene dichloride; D002725:Chloroform; D002251:Carbon Tetrachloride