IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells.
Expression of T1ST2, the IL-33R, by Th2 cells requires GATA3. Resting Th2 cells express little GATA3, which is increased by IL-33 and a STAT5 activator, in turn increasing T1ST2 from its low-level expression on resting Th2 cells. Th2 cells that have upregulated T1ST2 produce IL-13, but not IL-4, in response to IL-33 plus a STAT5 activator in an antigen-independent, NF-kappaB-dependent, cyclosporin A (CsA)-resistant manner. Similarly, Th17 cells produce IL-17A in response to IL-1beta and a STAT3 activator and Th1 cells produce IFNgamma in response to IL-18 and a STAT4 inducer. Thus, each effector Th cell produces cytokines without antigenic stimulation in response to an IL-1 family member and a specific STAT activator, implying an innate mechanism through which memory CD4 T cells are recruited by an induced cytokine environment.
Guo
Liying
L
Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Wei
Gang
G
Zhu
Jinfang
J
Liao
Wei
W
Leonard
Warren J
WJ
Zhao
Keji
K
Paul
William
W
D000818:Animals; D002478:Cells, Cultured; D016207:Cytokines / Q000096:biosynthesis*; D050990:GATA3 Transcription Factor / Q000378:metabolism; D007375:Interleukin-1 / Q000378:metabolism*; D018793:Interleukin-13 / Q000378:metabolism; D020381:Interleukin-17 / Q000378:metabolism; D007376:Interleukin-2 / Q000096:biosynthesis; D000067596:Interleukin-33; D015847:Interleukin-4 / Q000378:metabolism; D007378:Interleukins / Q000378:metabolism; D051379:Mice; D016328:NF-kappa B / Q000378:metabolism; D050778:NFATC Transcription Factors / Q000378:metabolism; D010766:Phosphorylation; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism; D017472:Receptors, Interleukin-1 / Q000378:metabolism; D050791:STAT Transcription Factors / Q000378:metabolism*; D050799:STAT5 Transcription Factor / Q000378:metabolism; D018417:Th1 Cells / Q000378:metabolism*; D018418:Th2 Cells / Q000378:metabolism*; D015854:Up-Regulation; D048051:p38 Mitogen-Activated Protein Kinases / Q000378:metabolism
D016207:Cytokines; D050990:GATA3 Transcription Factor; C506535:Il33 protein, mouse; D007375:Interleukin-1; D018793:Interleukin-13; D020381:Interleukin-17; D007376:Interleukin-2; D000067596:Interleukin-33; D007378:Interleukins; D016328:NF-kappa B; D050778:NFATC Transcription Factors; D011948:Receptors, Antigen, T-Cell; D017472:Receptors, Interleukin-1; D050791:STAT Transcription Factors; D050799:STAT5 Transcription Factor; D015847:Interleukin-4; D048051:p38 Mitogen-Activated Protein Kinases