title: Long-term clinical outcome and left ventricular lead position in cardiac resynchronization therapy.
abstract: OBJECTIVE
  To identify the predictive value of a presumed optimal left ventricular lead positions (LV-Ps) on the long-term clinical outcome in patients with cardiac resynchronization therapy (CRT).
  
  
  RESULTS
  Clinical information was collected from patient files in consecutive patients treated with CRT from 1997 to 2007. A presumed optimal LV-Ps were defined as a position between 2 and 5 o'clock in the short-axis circumference and basal or mid-ventricular in the long axis. Symptomatic response was defined as improvement in NYHA class (>or=1) and echocardiographic response as improvement in left ventricular ejection fraction of >or=5% absolute. We included 567 patients [median age 66 years, 453 (80%) male]. The LV-Ps were optimal in 334 (59%) patients. The hazard ratio for all-cause mortality with an optimal LV-Ps was unadjusted 0.79 (0.59-1.06) and adjusted 0.99 (0.71-1.40). The odds ratio (OR) for symptomatic response with an optimal LV-Ps was unadjusted 1.13 (0.79-1.64) and adjusted 1.05 (0.67-1.64), and the OR for echocardiographic response was unadjusted 1.60 (1.02-2.49) and adjusted 1.42 (0.88-2.31).
  
  
  CONCLUSIONS
  A presumed optimal LV-Ps between 2 and 5 o'clock in the short-axis circumference and basal or mid-ventricular in the long axis is not associated with a lower mortality or a better clinical response in patients treated with CRT.
authors: Department of Cardiology, Aarhus University Hospital, Skejby, Bendstrupgaardsvej 100, DK-8200 Aarhus N, Denmark. mads.brix.kronborg@ki.au.dk
authors: Mads Brix
authors: MB
authors: Kronborg
authors: Andi Eie
authors: AE
authors: Albertsen
authors: Jens Cosedis
authors: JC
authors: Nielsen
authors: Peter Thomas
authors: PT
authors: Mortensen
mesh_terms: D000368:Aged; D002304:Cardiac Pacing, Artificial / Q000401:mortality*; D015897:Comorbidity; D003718:Denmark / Q000453:epidemiology; D005260:Female; D006333:Heart Failure / Q000401:mortality* / Q000517:prevention & control*; D006801:Humans; D015994:Incidence; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors; D016019:Survival Analysis; D015996:Survival Rate; D016896:Treatment Outcome; D018487:Ventricular Dysfunction, Left / Q000401:mortality* / Q000517:prevention & control*