title: Intravitreal bevacizumab (Avastin) in the treatment of macular edema secondary to retinal vein occlusion.
abstract: OBJECTIVE
  To evaluate efficacy and safety of intravitreal injections of bevacizumab in the treatment of macular edema secondary to retinal vein occlusion (RVO).
  
  
  METHODS
  Prospective study, noncomparative, interventional case series. Twelve consecutive patients (12 eyes) with macular edema associated with nonischemic retinal vein occlusion were treated with intravitreal bevacizumab (1.25 mg). All subjects underwent standardized ophthalmic evaluation at baseline and at weeks 1, 4, 12, and 24, consisting of visual acuity (VA) measurement using ETDRS charts, and imaging with ocular coherence tomography evaluating changes in foveal thickness (FT) and macular volume (MV).
  
  
  RESULTS
  The median age was 66 years (+/- 4.16), and the median duration of symptoms was 4 months (+/- 1.81). There were six cases of inferior branch vein occlusion and six cases of superior branch retinal vein occlusion. Mean VA improved from 1.32 +/- 0.24 (logMAR values) at baseline to 0.8 +/- 0.15 (p = 0.0003) at the 6-month follow-up. The macular edema responded promptly, and a trend to restoration of normal macular anatomy was observed at by the seventh day. Mean FT improved from 615.50 +/- 116.29 microns to 420 +/- 72.53 microns (p = 0.001), and the mean MV improved from 19.81 +/- 2.31mm3 to 9.23 +/- 1.38 (p = 0.0001) at the 6-month follow-up.
authors: Department of Ophthalmology, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain.
authors: Juan Carlos Mesa
authors: JC
authors: Gutiérrez
authors: Luis Arias
authors: LA
authors: Barquet
authors: Josep Maria
authors: JM
authors: Caminal
authors: Mitjana
authors: Sergi Prades
authors: SP
authors: Almolda
authors: Nùria Planas
authors: NP
authors: Domènech
authors: Octavi Pujol
authors: OP
authors: Goita
authors: Marc Rubio
authors: MR
authors: Caso
authors: Jorge Arruga
authors: JA
authors: Ginebreda