title: Plastic bronchitis as an unusual cause of mucus plugging in cystic fibrosis.
abstract: Cystic fibrosis patients are known to produce abundant, purulent sputum consisting mainly of DNA and cellular debris. We present a case of a CF patient with recurrent airway obstruction caused by a rare condition known as plastic bronchitis (PB). PB is characterized by the formation of casts of the airways that cause obstruction. Multiple etiologies have been proposed, but to our knowledge, no CF patient has been reported in any PB classification. Histological analysis and in-vitro testing of the cast were important factors in choosing the adequate therapy in this patient.
authors: Division of Respiratory Medicine, Hospital for Sick Children, Toronto, Canada. dimasmateos@yahoo.com
authors: Dimas
authors: D
authors: Mateos-Corral
authors: Ernest
authors: E
authors: Cutz
authors: Melinda
authors: M
authors: Solomon
authors: Felix
authors: F
authors: Ratjen
mesh_terms: D000111:Acetylcysteine / Q000008:administration & dosage*; D000280:Administration, Inhalation; D001991:Bronchitis / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000150:complications / Q000188:drug therapy*; D005100:Expectorants / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D009093:Mucus; D029424:Pulmonary Disease, Chronic Obstructive / Q000188:drug therapy* / Q000209:etiology
chemical_list: D005100:Expectorants; D000111:Acetylcysteine