Monitoring anticoagulation of primary haemostasis--estimation of platelet function in whole blood assays.
This article provides an overview on current commercially available methods to determine primary haemostasis as a target of drug-mediated anticoagulation. It focuses on whole blood methods only, and references the currently major achievements that have been reported with each method in respect to its clinical use. Advantages and disadvantages of the various methods are presented, based on considerations of platelet physiology, and on feasibility of the procedures.
Calatzis
A
A
Department for Transfusion Medicine and Haemostaseology, University Hospital Munich, Munich, Germany.
Leitner
M
M
Panzer
S
S
D000925:Anticoagulants / Q000627:therapeutic use*; D001777:Blood Coagulation / Q000187:drug effects / Q000502:physiology; D001792:Blood Platelets / Q000187:drug effects / Q000502:physiology*; D005434:Flow Cytometry; D006487:Hemostasis / Q000187:drug effects*; D006801:Humans; D010973:Platelet Adhesiveness / Q000187:drug effects; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D012189:Retrospective Studies
D000925:Anticoagulants; D010975:Platelet Aggregation Inhibitors