[Maternal serum screening: possibilities of using in the complex diagnosis of fetal malformation].
Along with ultrasonography, maternal serum screening is an initial stage of a diagnostic process of genetically determined fetal malformation. Based on the performed clinical and statistical study, the author estimated the values of alpha-fetoprotein and beta-subunit of chorionic gonadotropin if the fetus has malformations of the central nervous system, heart, anterior abdominal wall, and urinary tract and Down's syndrome. The informative value of alpha-fetoprotein was confirmed in malformations of the anterior abdominal wall (gastroschisis, omphalocele) and the central nervous system (hydrocephalus, spinal hernia) and that of chorionic gonadotropin in Down's syndrome in a fetus of 15 to 24 weeks gestation.
Antonova
I V
IV
D015415:Biomarkers / Q000032:analysis / Q000097:blood; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood*; D000013:Congenital Abnormalities / Q000097:blood / Q000175:diagnosis*; D005260:Female; D005865:Gestational Age; D006801:Humans; D011247:Pregnancy / Q000097:blood*; D011296:Prenatal Diagnosis / Q000379:methods*; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D000509:alpha-Fetoproteins / Q000032:analysis*
D015415:Biomarkers; D018997:Chorionic Gonadotropin, beta Subunit, Human; D000509:alpha-Fetoproteins