title: Prospective cardiac gating of carotid three-dimensional ultrasound.
abstract: Quantitative measurements of carotid atherosclerosis can be determined using three-dimensional ultrasound (3DUS). This pilot study involved the development of prospective cardiac gating of 3DUS carotid images to reduce cardiac cycle-derived arterial pulsatility. The method developed uses electrocardiograph signal detection of the cardiac cycle R wave with imaging acquisition delayed in time (deltat) after the R wave is detected. Pulsatility of the common carotid artery was measured by calculating the mean percentage change in arterial cross-sectional area (%deltaA) in moderate atherosclerosis (MA) patients (12% +/- 1%) and healthy volunteers (HVs) (16% +/- 3%) and found that %deltaA was significantly higher for HV than for MA (p = 0.016) when no cardiac gating was used. The cardiac gating method was tested with deltat = 250 ms and deltat = 400 ms in young healthy volunteers and rheumatoid arthritis (RA) patients. For all 3DUS measurements acquired without gating, there was a significant association between %deltaA and age (r2 = 0.20, p = 0.035), and mean %deltaA (in HV and RA) was 13% +/- 5% [95% confidence interval (CI) = 10%-17%]. For deltat = 250 ms mean %deltaA was significantly different and decreased to 7% +/- 3% (95% CI = 5%-10%) and for deltat = 400 ms it was significantly different and decreased to 6% +/- 1% (95% CI = 6%-7%) (p = 0.001 for both comparisons). There was no significant difference in mean %deltaA between gating conditions (p = 0.8); however, the 95% CI for %deltaA was decreased for deltat = 400 ms as compared to deltat = 250 ms. Both gating methods also significantly decreased %deltaA to below the reference standard of 12% +/- 1% for MA (p < 0.01 for both comparisons), suggesting that prospective cardiac gating of carotid 3DUS reduces pulsatility effects in HV and RA to levels lower than observed for much older MA patients.
authors: Imaging Research Laboratories, Robarts Research Institute, London, Ontario N6A 5K8, Canada.
authors: Christiane
authors: C
authors: Mallett
authors: Lori
authors: L
authors: Gardi
authors: Aaron
authors: A
authors: Fenster
authors: Grace
authors: G
authors: Parraga
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D001172:Arthritis, Rheumatoid / Q000000981:diagnostic imaging / Q000503:physiopathology; D055424:Cardiac-Gated Imaging Techniques / Q000379:methods*; D002339:Carotid Arteries / Q000000981:diagnostic imaging* / Q000502:physiology / Q000503:physiopathology; D002340:Carotid Artery Diseases / Q000000981:diagnostic imaging / Q000503:physiopathology; D019560:Echocardiography, Three-Dimensional / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010507:Periodicity; D010865:Pilot Projects; D013997:Time Factors