Click chemistry based rapid one-pot synthesis and evaluation for protease inhibition of new tetracyclic triazole fused benzodiazepine derivatives.
We describe herein a one-pot synthesis of novel tetracyclic scaffolds that incorporate a fusion of a proline, 1,2,3-triazole ring with [1,4]-benzodiazepin-8(4H)-one ring systems following click chemistry. The expected peptide bond formation followed by in situ 1,3-dipolar cycloaddition in absence of any catalyst led to the formation of new triazole fused benzodiazepine derivatives.
Mohapatra
Debendra K
DK
Organic Chemistry Division, National Chemical Laboratory (CSIR), Pune, India. mohapatra@iict.res.in
Maity
Pradip K
PK
Shabab
M
M
Khan
M I
MI
D001569:Benzodiazepines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D018360:Crystallography, X-Ray; D003546:Cysteine Endopeptidases / Q000737:chemistry / Q000378:metabolism; D008968:Molecular Conformation; D011480:Protease Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D012697:Serine Endopeptidases / Q000737:chemistry / Q000378:metabolism; D014230:Triazoles / Q000737:chemistry*
D011480:Protease Inhibitors; D014230:Triazoles; D001569:Benzodiazepines; D012697:Serine Endopeptidases; D003546:Cysteine Endopeptidases