title: Laboratory testing for von Willebrand disease: toward a mechanism-based classification.
abstract: The heterogeneity of von Willebrand disease reflects the varied roles of von Willebrand factor in coagulation. Significant challenges remain in the detection, classification, and determination of bleeding risk in disorders related to von Willebrand factor. A clearer understanding of the specific disease mechanisms is essential to the development of improved methods for prognosis and management in this and other conditions with abnormalities of the von Willebrand factor system.
authors: Department of Laboratory Medicine, Yale School of Medicine, 333 Cedar Street, P.O. Box 208035, New Haven, CT 06520-8035, USA. richard.torres@yale.edu
authors: Richard
authors: R
authors: Torres
authors: Yuri
authors: Y
authors: Fedoriw
mesh_terms: D000017:ABO Blood-Group System; D019411:Clinical Laboratory Techniques; D004586:Electrophoresis / Q000379:methods; D005434:Flow Cytometry / Q000379:methods; D006801:Humans; D008954:Models, Biological; D010979:Platelet Function Tests / Q000379:methods; D055503:Protein Multimerization; D017434:Protein Structure, Tertiary; D014842:von Willebrand Diseases / Q000097:blood / Q000145:classification* / Q000175:diagnosis*; D014841:von Willebrand Factor / Q000502:physiology
chemical_list: D000017:ABO Blood-Group System; D014841:von Willebrand Factor