Antioxidant effect of polyphenolic glabridin on LDL oxidation.
This study was conducted to determine the effect of a natural polyphenolic isoflavone antioxidant (Glabridin) on low-density lipoprotein (LDL) oxidation. Determination of the extent of LDL oxidation was done by measuring the formation of Thiobarbituric acid reactive substances (TBARS). After oral administration of licorice-root ethanol extract to healthy subjects for 6 months, the subjects' oxidative stress level as well as plasma LDL oxidation reduced by 20%. We concluded that dietary consumption of glabridin protects LDL from oxidation.
Carmeli
E
E
Physical Therapy, Tel Aviv University, Tel Aviv, Israel. elie@post.tau.ac.il
Fogelman
Y
Y
D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000494:pharmacology*; D008078:Cholesterol, LDL / Q000378:metabolism*; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005260:Female; D005419:Flavonoids; D006035:Glycyrrhiza; D006801:Humans; D007529:Isoflavones / Q000494:pharmacology*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000187:drug effects*; D010636:Phenols / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology; D018517:Plant Roots; D059808:Polyphenols; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
D000975:Antioxidants; D008078:Cholesterol, LDL; D005419:Flavonoids; D007529:Isoflavones; D010636:Phenols; D010936:Plant Extracts; D059808:Polyphenols; D017392:Thiobarbituric Acid Reactive Substances; C107601:glabridin