title: CADISP-genetics: an International project searching for genetic risk factors of cervical artery dissections.
abstract: BACKGROUND
  Cervical artery dissection (CAD) is a frequent cause of ischemic stroke, and occasionally death, in young adults. Several lines of evidence suggest a genetic predisposition to CAD. However, previous genetic studies have been inconclusive mainly due to insufficient numbers of patients. Our hypothesis is that CAD is a multifactorial disease caused by yet largely unidentified genetic variants and environmental factors, which may interact. Our aim is to identify genetic variants associated with an increased risk of CAD and possibly gene-environment interactions.
  
  
  METHODS
  We organized a multinational European network, Cervical Artery Dissection and Ischemic Stroke Patients (CADISP), which aims at increasing our knowledge of the pathophysiological mechanisms of this disease in a large group of patients. Within this network, we are aiming to perform a de novo genetic association analysis using both a genome-wide and a candidate gene approach. For this purpose, DNA from approximately 1100 patients with CAD, and 2000 healthy controls is being collected. In addition, detailed clinical, laboratory, diagnostic, therapeutic, and outcome data are being collected from all participants applying predefined criteria and definitions in a standardized way. We are expecting to reach the above numbers of subjects by early 2009.
  
  
  CONCLUSIONS
  We present the strategy of a collaborative project searching for the genetic risk factors of CAD. The CADISP network will provide detailed and novel data on environmental risk factors and genetic susceptibility to CAD.
authors: Department of Neurology, University Hospital of Lille, Lille, France.
authors: S
authors: S
authors: Debette
authors: T M
authors: TM
authors: Metso
authors: A
authors: A
authors: Pezzini
authors: S T
authors: ST
authors: Engelter
authors: D
authors: D
authors: Leys
authors: P
authors: P
authors: Lyrer
authors: A J
authors: AJ
authors: Metso
authors: T
authors: T
authors: Brandt
authors: M
authors: M
authors: Kloss
authors: C
authors: C
authors: Lichy
authors: I
authors: I
authors: Hausser
authors: E
authors: E
authors: Touzé
authors: H S
authors: HS
authors: Markus
authors: S
authors: S
authors: Abboud
authors: V
authors: V
authors: Caso
authors: A
authors: A
authors: Bersano
authors: A
authors: A
authors: Grau
authors: A
authors: A
authors: Altintas
authors: P
authors: P
authors: Amouyel
authors: T
authors: T
authors: Tatlisumak
authors: J
authors: J
authors: Dallongeville
authors: C
authors: C
authors: Grond-Ginsbach
mesh_terms: D000328:Adult; D002545:Brain Ischemia / Q000453:epidemiology / Q000235:genetics; D004247:DNA / Q000235:genetics; D004777:Environment; D005787:Gene Frequency; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D011110:Polymorphism, Genetic / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011786:Quality Control; D012107:Research Design; D012307:Risk Factors; D020521:Stroke / Q000150:complications / Q000453:epidemiology* / Q000235:genetics*; D016896:Treatment Outcome; D020217:Vertebral Artery Dissection / Q000150:complications / Q000453:epidemiology* / Q000235:genetics*; D044465:White People
chemical_list: D004247:DNA