title: Preliminary evidence of disease response to the pan deacetylase inhibitor panobinostat (LBH589) in refractory Hodgkin Lymphoma.
abstract: There are few treatment options for patients with Hodgkin Lymphoma (HL) who relapse after conventional therapies. Panobinostat is an orally available pan deacetylase inhibitor with evidence of activity in myeloid malignancies and cutaneous T cell lymphoma. Thirteen HL patients were treated with escalating doses of this novel agent in a phase IA/II multicentre study. A computed tomography partial response was achieved in 5/13(38%), and a metabolic response by (18)F-fluoro-2-deoxy-D-glucose positron emission tomography scanning in 7/12 (58%) evaluable patients. This report describes the preliminary evidence of anti-tumour activity seen in the early phase of this study, which recently closed to accrual.
authors: Haematology Service, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
authors: Michael
authors: M
authors: Dickinson
authors: David
authors: D
authors: Ritchie
authors: Daniel J
authors: DJ
authors: DeAngelo
authors: Andrew
authors: A
authors: Spencer
authors: Oliver G
authors: OG
authors: Ottmann
authors: Thomas
authors: T
authors: Fischer
authors: Kapil N
authors: KN
authors: Bhalla
authors: Angela
authors: A
authors: Liu
authors: Katie
authors: K
authors: Parker
authors: Jeffrey W
authors: JW
authors: Scott
authors: Mark
authors: M
authors: Bishton
authors: H Miles
authors: HM
authors: Prince
mesh_terms: D000293:Adolescent; D000328:Adult; D004305:Dose-Response Relationship, Drug; D005260:Female; D019788:Fluorodeoxyglucose F18; D056572:Histone Deacetylase Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D006689:Hodgkin Disease / Q000000981:diagnostic imaging / Q000188:drug therapy*; D006801:Humans; D006877:Hydroxamic Acids / Q000008:administration & dosage / Q000627:therapeutic use*; D007211:Indoles; D008297:Male; D008875:Middle Aged; D000077767:Panobinostat; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D056572:Histone Deacetylase Inhibitors; D006877:Hydroxamic Acids; D007211:Indoles; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D000077767:Panobinostat