title: Kaposi sarcoma-associated herpesvirus (KSHV): molecular biology and oncogenesis.
abstract: Kaposi sarcoma-associated herpesvirus (KSHV) is a double-stranded DNA herpesvirus belonging to the gamma-herpesvirinae subfamily. KSHV has been associated with the development of three neoplastic diseases: Kaposi sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman disease (MCD). In this review, we discuss the three KSHV-associated malignancies, KSHV genome, latent and lytic aspects of the viral lifecycle, putative viral oncogenes, as well as therapeutic regimens used for the treatment of KS, PEL, and MCD.
authors: Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.
authors: Kwun Wah
authors: KW
authors: Wen
authors: Blossom
authors: B
authors: Damania
mesh_terms: D005871:Castleman Disease / Q000821:virology*; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D019288:Herpesvirus 8, Human / Q000502:physiology*; D006801:Humans; D054685:Lymphoma, Primary Effusion / Q000821:virology*; D009858:Oncogenic Viruses; D012514:Sarcoma, Kaposi / Q000821:virology*; D014412:Tumor Virus Infections / Q000821:virology; D017735:Virus Latency