Clinical significance of serum 7-ketocholesterol concentrations in the progression of coronary atherosclerosis.
OBJECTIVE
7-Ketocholesterol concentrations can be measured in a blood sample; however, the relationship between blood 7-ketocholesterol concentrations and atherosclerotic disease is not well-known. The aim of this study was to clarify the clinical significance of serum 7-ketocholesterol concentrations (s-7KCHO) in the progression of coronary atherosclerosis.


METHODS
One hundred and thirty-nine subjects with coronary artery disease (CAD, subjects with stable angina pectoris or acute myocardial infarction) and 43 subjects with normal coronary arteries were enrolled in the study. s-7KCHO was measured using gas chromatography mass spectrometry.


RESULTS
s-7KCHO was significantly higher in subjects with CAD than in those with normal coronary arteries (normal coronary artery: 19.0+/-11.3 ng/mL, CAD: 32.4+/-23.1 ng/mL, p<0.01). Furthermore, patients with multiple vessel disease had significantly higher s-7KCHO than those with single vessel disease. Multivariate analysis revealed that s-7KCHO was an independent variable for CAD (p<0.01). In CAD subjects, the presence of acute myocardial infarction, number of affected vessels, and high sensitive C-reactive protein concentrations strongly correlated with s-7KCHO (p<0.01, <0.05, <0.05, respectively).


CONCLUSIONS
These results indicate that high s-7KCHO is closely associated with the progression of coronary atherosclerosis and inflammation.
Hitsumoto
Takashi
T
The Department of Internal Medicine, Sakura Medical Center, School of Medicine, Toho University, Chiba, Japan. thitsu@jcom.home.ne.jp
Takahashi
Mao
M
Iizuka
Takuo
T
Shirai
Kohji
K
D000368:Aged; D000787:Angina Pectoris; D002097:C-Reactive Protein / Q000032:analysis; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000097:blood* / Q000453:epidemiology / Q000473:pathology; D018450:Disease Progression; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood; D007653:Ketocholesterols / Q000097:blood*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction
D007653:Ketocholesterols; D002097:C-Reactive Protein; C003001:7-ketocholesterol