Semisynthesis of Taxol.
The semisynthesis of Taxol was critical to its development as a drug. This review focuses on methods that have been developed to convert the readily available 10-deacetylbaccatin III (10-DAB) into Taxol, highlighting the various protection schemes used for the phenylisoserine side chain and 10-DAB, along with the methods developed for the conjoining of the side chain to the hindered C-13 hydroxyl of the diterpenoid framework.
Wuts
P G
PG
1500-91-2, Pharmacia and Upjohn, Kalamazoo, MI 49001, USA. Peter.G.Wuts@am.pnu.com