Hyperventilation during orthostatic challenge in spinal cord-injured humans.
OBJECTIVE
To determine whether arterial hypotension is related to hyperventilation during standing in individuals with complete spinal cord injury (SCI).


METHODS
Sixteen individuals with SCI (thoracic 1 to thoracic level 12, ASIA grade: A) and 18 able-bodied individuals participated in this study. Individuals with SCI were divided into a group with injury level at or above thoracic (T) 7 [higher SCI (HSCI), n = 9] and a group with injury level at or below T10 (lower SCI, n = 7). Subjects carried out 6-min quiet sitting and then 6-min quiet standing using a standing frame.


RESULTS
Significant decrease in mean arterial blood pressure (MAP) and significant increase in minute ventilation (V(E)) by postural change from sitting to standing were observed only in HSCI. In HSCI, MAP decreased from 81 +/- 11 to 75 +/- 16 mmHg (P < 0.05), while V(E) increased from 8.4 +/- 1.1 to 9.9 +/- 1.0 l min(-1) (P < 0.01). There was a significant negative correlation between changes in MAP and V(E) in subjects in the HSCI group (r = -0.72, P < 0.05).


CONCLUSIONS
We concluded that the magnitude of hyperventilation during standing is associated with individual difference in the magnitude of hypotension in individuals with SCI. The mechanism(s) for this relationship remains unresolved, but afferent signals from baroreceptors to the brainstem respiratory center and/or action of pressor substances on the central nervous system might have caused hyperventilation.
Ogata
Hisayoshi
H
Department of Rehabilitation for Movement Functions, Research Institute of National Rehabilitation Center for Persons with Disabilities, Tokorozawa, Saitama, Japan. hisaoga@rehab.go.jp
Nakahara
Miwa
M
Sato
Takeshi
T
Hoshikawa
Shinya
S
Ogata
Toru
T
Nakazawa
Kimitaka
K
D000328:Adult; D001794:Blood Pressure / Q000502:physiology; D006801:Humans; D006985:Hyperventilation / Q000209:etiology* / Q000503:physiopathology; D007024:Hypotension, Orthostatic / Q000209:etiology* / Q000503:physiopathology; D008297:Male; D013116:Spinal Cord / Q000503:physiopathology*; D013119:Spinal Cord Injuries / Q000150:complications / Q000503:physiopathology*; D055815:Young Adult