Synthesis, antifungal, haemolytic and cytotoxic activities of a series of bis(alkylpyridinium)alkanes.
A series of bis(alkylpyridinium)alkanes with a twelve carbon spacer between the positive charges was synthesised and their antifungal activity has been investigated. Compounds with 2-pentyl, 4-pentyl, 4-hexyl, 4-octyl, 4-propylbenzene, 3,4-dipentyl, 4-(5'-nonyl) and 3-methyl,4-pentyl head groups were the most potent antifungal agents with MICs in the range of 1.4-2.7 microM against reference strains of both Cryptococcus neoformans and Candida albicans.
Obando
Daniel
D
School of Chemistry, The University of Sydney, 2006 NSW, Australia.
Pantarat
Namfon
N
Handke
Rosemary
R
Koda
Yasuko
Y
Widmer
Fred
F
Djordjevic
Julianne T
JT
Ellis
David H
DH
Sorrell
Tania C
TC
Jolliffe
Katrina A
KA
D000818:Animals; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D002176:Candida albicans / Q000187:drug effects; D003455:Cryptococcus neoformans / Q000187:drug effects; D006461:Hemolysis; D008245:Lysophospholipase / Q000037:antagonists & inhibitors / Q000378:metabolism; D008826:Microbial Sensitivity Tests; D064801:Phospholipase A2 Inhibitors; D054467:Phospholipases A2 / Q000378:metabolism; D011726:Pyridinium Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D013552:Swine
D000935:Antifungal Agents; D064801:Phospholipase A2 Inhibitors; D011726:Pyridinium Compounds; D054467:Phospholipases A2; D008245:Lysophospholipase