title: Efficient synthesis of flavanone glucuronides.
abstract: The first efficient synthesis of flavanone glucuronides as potential human metabolites is described. The synthetic strategy is based on acetyl protection, followed by a combination of chemical and enzymatic deprotection steps. As an example, the method is applied to a synthesis of 7,4'-di-O-methyleriodictyol 3'-O-beta-d-glucuronide. The aglycone is a flavanone naturally present in tarragon spice ( Artemisia dracunculus ) as well as in various Chinese, Brazilian, and Malaysian medicinal plants.
authors: Départment de Pharmacochimie Moléculaire, UMR 5063, ICMG-FR 2607, Grenoble University, Grenoble Cedex 9, France.
authors: Ahcene
authors: A
authors: Boumendjel
authors: Madeleine
authors: M
authors: Blanc
authors: Gary
authors: G
authors: Williamson
authors: Denis
authors: D
authors: Barron
mesh_terms: D002617:Chemical Industry / Q000379:methods*; D044950:Flavanones / Q000138:chemical synthesis* / Q000737:chemistry; D020719:Glucuronides / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
chemical_list: D044950:Flavanones; D020719:Glucuronides; C028610:flavanone