title: Preliminary results following the use of a fixed combination of timolol-brimonidine in patients with ocular hypertension and primary open-angle glaucoma.
abstract: OBJECTIVE
  The purpose of this prospective study was to evaluate the efficacy in intraocular pressure (IOP) control and the tolerance of a topically administered fixed combination of timolol-brimonidine in 50 patients with ocular hypertension and primary open-angle glaucoma.
  
  
  METHODS
  After determining a baseline IOP, the fixed combination timolol-brimonidine was used twice daily for two months, while IOP, ophthalmic signs, and/or symptoms were monitored.
  
  
  RESULTS
  The mean IOP value was decreased from 23.09 mm Hg (+/-1.98 SD) to 17.46 mm Hg (+/-1.47 SD) during the 1st month (paired Student's t test = 9.88 kappaalphaiota p < 0.001), and to 17.51 mm Hg (+/-1.43 SD) in the 2nd month. Between the 1st and 2nd month, no statistical difference was observed (paired Student's t test = 0.02 kappaalphaiota p > 0.1). In 8% of the patients during the 1st month and 10% of patients in the 2nd month, some ophthalmic signs were observed, while only mild ophthalmic symptoms were reported in 6% and 8% of the patients, respectively.
  
  
  CONCLUSIONS
  In conclusion, the fixed combination of timolol-brimonidine has a satisfactory IOP-lowering effect without any serious side effects due to the topical use.
authors: Department of Ophthalmology, "G Gennimatas" Hospital of Athens, University of Athens, Athens, Greece. dpapaconstantinou@hotmail.com
authors: Dimitris
authors: D
authors: Papaconstantinou
authors: Ilias
authors: I
authors: Georgalas
authors: Nikolaos
authors: N
authors: Kourtis
authors: Christos
authors: C
authors: Pitsas
authors: Efthimios
authors: E
authors: Karmiris
authors: Chrysanthi
authors: C
authors: Koutsandrea
authors: Ioannis
authors: I
authors: Ladas
authors: Gerasimos
authors: G
authors: Georgopoulos