DNA makes RNA makes innate immunity.
Microbial DNA in the cytosol induces production of interferon-beta (IFN-beta) and an innate immune response. Chiu et al. (2009) now implicate cytosolic DNA-dependent RNA polymerase III as the DNA sensor linking DNA release by pathogenic bacteria and viruses in the host cell cytosol to IFN-beta production and innate immunity.
O'Neill
Luke A J
LA
School of Biochemistry and Immunology, Trinity College Dublin, College Green, Dublin 2, Ireland. laoneill@tcd.ie
D000818:Animals; D004247:DNA / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D016899:Interferon-beta / Q000276:immunology; D053583:Interleukin-1beta / Q000276:immunology; D012313:RNA / Q000276:immunology*; D012320:RNA Polymerase III / Q000378:metabolism
D053583:Interleukin-1beta; D012313:RNA; D016899:Interferon-beta; D004247:DNA; D012320:RNA Polymerase III