title: Role of Staphylococcus aureus nasal colonization in atopic dermatitis in infants: the Generation R Study.
abstract: OBJECTIVE
  To study the association between Staphylococcus aureus nasal colonization and atopic dermatitis (AD) in infancy.
  
  
  METHODS
  Population-based prospective cohort study of pregnant women and their children.
  
  
  METHODS
  This project was embedded in the Generation R Study.
  
  
  METHODS
  A total of 1079 postnatal Dutch infants/children participated in the focus cohort. Main Exposures Nasal swabs for S aureus cultivation were taken at ages 1.5, 6, and 14 months. Main Outcome Measure Questionnaires that pertain to AD and confounders (birth weight, gestational age, sex, and parental eczema) were completed prenatally and postnatally. The outcome was AD in the first and second years of life.
  
  
  RESULTS
  A first positive culture for S aureus at age 6 months was associated with AD prevalence in the first and second years of life (adjusted odds ratio [aOR], 2.13; 95% confidence interval [CI], 1.17-3.87; and aOR, 2.88; 95% CI, 1.60-5.19, respectively) and also with severity (aOR, 3.27; 95% CI, 1.30-8.03). Moreover, frequent colonization in the first year of life (>/=2 times) held a 4.29-fold (95% CI, 1.03- to 17.88-fold) risk of moderate to severe AD in the second year of life.
  
  
  CONCLUSIONS
  Colonization with S aureus at age 6 months and frequent colonization in the first year of life are associated with AD and its severity in young children.
authors: Department of Pediatrics, Erasmus Medical Center-Sophia Children's Hospital, University Medical Center, PO Box 2060, 3000 CB Rotterdam, The Netherlands. h.a.moll@erasmusmc.nl
authors: Ankie
authors: A
authors: Lebon
authors: Joost A M
authors: JA
authors: Labout
authors: Henri A
authors: HA
authors: Verbrugh
authors: Vincent W V
authors: VW
authors: Jaddoe
authors: Albert
authors: A
authors: Hofman
authors: Willem J B
authors: WJ
authors: van Wamel
authors: Alex
authors: A
authors: van Belkum
authors: Henriëtte A
authors: HA
authors: Moll
mesh_terms: D015986:Confounding Factors, Epidemiologic; D003876:Dermatitis, Atopic / Q000453:epidemiology / Q000382:microbiology*; D005260:Female; D006801:Humans; D007223:Infant; D016015:Logistic Models; D009296:Nasal Cavity / Q000382:microbiology*; D009426:Netherlands / Q000453:epidemiology; D011247:Pregnancy; D011446:Prospective Studies; D012307:Risk Factors; D013211:Staphylococcus aureus / Q000302:isolation & purification*; D011795:Surveys and Questionnaires