title: Separation and preconcentration of aluminum in parenteral solutions and bottled mineral water using different analytical techniques.
abstract: A new method is reported for the separation of aluminum ions [Al(III)] from interfering elements in parenteral and pharmaceutical solutions (PS) and bottled mineral water (BMW) samples, through solid-phase extraction with 2-methyl-8-hydroxyquinoline (quinaldine) adsorbed onto activated silica gel. While the enrichment step of separated Al(III) was carried out by cloud point extraction (CPE) using 8-hydroxyquinoline as complexing reagent, the resulted complex was entrapped in a non-ionic surfactant octylphenoxypolyethoxyethanol (Triton X-114). The enriched Al(III) in sample solutions were determined by spectrofluorometry (SPF) at lambda(excitation) 370 nm and lambda(emission) 510 nm, and flame atomic absorption spectrometry (FAAS) for comparative purpose. The variables affecting the complexation and extraction steps were studied and optimized. The validity of methodology was checked with certified reference material of water and standard addition method. The enrichment factor and detection limit of Al(III) for the preconcentration of 50 ml of PS and BMW were found to be 100 and 0.25 microg/L, respectively. The proposed method has been applied for the determination of trace amount of Al(III) in PS and BMW samples with satisfactory results. In PS the levels of Al(III) are above than permissible limit (25 microg/L).
authors: Center of Excellence in Analytical Chemistry, University of Sindh, Jamshoro 76080, Pakistan. tgkazi@yahoo.com
authors: Tasneem G
authors: TG
authors: Kazi
authors: Sumaira
authors: S
authors: Khan
authors: Jameel A
authors: JA
authors: Baig
authors: Nida F
authors: NF
authors: Kolachi
authors: Hassan I
authors: HI
authors: Afridi
authors: Ghulam A
authors: GA
authors: Kandhro
authors: Sham
authors: S
authors: Kumar
authors: Abdul Q
authors: AQ
authors: Shah
mesh_terms: D000535:Aluminum / Q000302:isolation & purification*; D008722:Methods; D008900:Mineral Waters / Q000032:analysis*; D019999:Pharmaceutical Solutions / Q000032:analysis*; D011798:Quinaldines; D052616:Solid Phase Extraction; D013057:Spectrum Analysis; D013501:Surface-Active Agents
chemical_list: D008900:Mineral Waters; D019999:Pharmaceutical Solutions; D011798:Quinaldines; D013501:Surface-Active Agents; D000535:Aluminum; C037073:2-methylquinoline