title: Sub-acute toxicity evaluation of an aqueous extract of Labisia pumila, a Malaysian herb.
abstract: Labisia pumila (Myrsinaceae), is a popular herb among the women in Malaysia known locally as "Kacip Fatimah". Recently many nutraceutical products containing the powdered or extracted parts of the plant have become available for women's health care. However no evaluation of the effect of the repeated dosing of any herbal product of this plant had been undertaken prior to a 28-day sub-acute study presented in this report. The results showed that a dose of 50mg/kg of an aqueous extract of L. pumila corresponded to no-adverse-effect-level (NOAEL), whereas higher doses were associated with some toxicity concerns.
authors: Division of Pharmacology, Indian Institute of Integrative Medicine, Jammu 180001, India.
authors: G D
authors: GD
authors: Singh
authors: M
authors: M
authors: Ganjoo
authors: M S
authors: MS
authors: Youssouf
authors: A
authors: A
authors: Koul
authors: R
authors: R
authors: Sharma
authors: S
authors: S
authors: Singh
authors: P L
authors: PL
authors: Sangwan
authors: S
authors: S
authors: Koul
authors: D B
authors: DB
authors: Ahamad
authors: R K
authors: RK
authors: Johri
mesh_terms: D000818:Animals; D001653:Bile Ducts, Intrahepatic / Q000187:drug effects / Q000473:pathology; D019963:Clinical Chemistry Tests; D019587:Dietary Supplements / Q000032:analysis / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006403:Hematologic Tests; D006965:Hyperplasia / Q000139:chemically induced / Q000473:pathology; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008136:Longevity / Q000187:drug effects; D008168:Lung / Q000187:drug effects / Q000473:pathology; D008296:Malaysia; D008297:Male; D019055:No-Observed-Adverse-Effect Level; D010936:Plant Extracts / Q000032:analysis / Q000633:toxicity*; D010946:Plants, Medicinal; D029623:Primulaceae / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D018675:Toxicity Tests; D016482:Urinalysis
chemical_list: D010936:Plant Extracts