[Impact of HBV infection and alcohol surrogates on the lipid composition of lymphocytic membranes].
Our study was undertaken to reveal the specific features of changes in the content of different fractions of total and lymphocytic membrane phospholipids under the influence of HBV infection and alcohol substitutes. The lipid spectrum of lymphocytic membranes was determined in 50 healthy individuals, 50 patients with acute viral hepatitis, and 62 patients with toxic hepatitis. Once HBV infection occurs, there is a reduction in the content of total phospholipids, free cholesterol, phosphatidylcholine, and phosphatidylethanolamine and an increase in the level of triglycerides, free fatty acids, cholesterol esters, and lysophospholipids. There was also a decrease in the absolute content of total phospholipids and free cholesterol. The effect of alcohol substitutes was manifested by the higher concentrations of lysophospholipids, phosphatidylcholine, and phosphatidylethanolamine in the lymphocytic membranes.
Makarov
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VK
Riasenskiĭ
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DS
D000328:Adult; D000434:Alcoholic Beverages / Q000592:standards / Q000633:toxicity*; D016022:Case-Control Studies; D002462:Cell Membrane / Q000378:metabolism*; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood* / Q000378:metabolism; D006509:Hepatitis B / Q000097:blood* / Q000378:metabolism; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism*; D008563:Membrane Lipids / Q000097:blood*; D008875:Middle Aged; D010743:Phospholipids / Q000097:blood
D008563:Membrane Lipids; D010743:Phospholipids