New antitumour fungal metabolites from Alternaria porri.
Chemical investigation of the onion pathogenic fungus Alternaria porri resulted in the isolation of two new phthalides named zinnimide (2) and deprenylzinnimide (8), along with a new bianthraquinone, alterporriol F (10). The structures of the new metabolites were characterised by spectroscopic analysis and chemical degradation. Of the new compounds isolated, alterporriol F was highly cytotoxic towards HeLa and KB cells, with IC(50) values of 6.5 and 7.0 microg mL(-1).
Phuwapraisirisan
Preecha
P
Natural Products Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand. preecha.p@chula.ac.th
Rangsan
Jakaphan
J
Siripong
Pongpan
P
Tip-Pyang
Santi
S
D000528:Alternaria / Q000737:chemistry* / Q000378:metabolism; D000880:Anthraquinones / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D001572:Benzofurans / Q000737:chemistry / Q000494:pharmacology; D003124:Colorimetry / Q000379:methods; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D007624:KB Cells / Q000187:drug effects; D007783:Lactones / Q000737:chemistry / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010795:Phthalic Acids / Q000737:chemistry / Q000494:pharmacology
D000880:Anthraquinones; D000970:Antineoplastic Agents; D001572:Benzofurans; D007783:Lactones; D010795:Phthalic Acids; C032279:phthalic acid; C082022:phthalide; C005197:alternariol