Auditory cortical activity during cochlear implant-mediated perception of spoken language, melody, and rhythm.
Despite the significant advances in language perception for cochlear implant (CI) recipients, music perception continues to be a major challenge for implant-mediated listening. Our understanding of the neural mechanisms that underlie successful implant listening remains limited. To our knowledge, this study represents the first neuroimaging investigation of music perception in CI users, with the hypothesis that CI subjects would demonstrate greater auditory cortical activation than normal hearing controls. H(2) (15)O positron emission tomography (PET) was used here to assess auditory cortical activation patterns in ten postlingually deafened CI patients and ten normal hearing control subjects. Subjects were presented with language, melody, and rhythm tasks during scanning. Our results show significant auditory cortical activation in implant subjects in comparison to control subjects for language, melody, and rhythm. The greatest activity in CI users compared to controls was seen for language tasks, which is thought to reflect both implant and neural specializations for language processing. For musical stimuli, PET scanning revealed significantly greater activation during rhythm perception in CI subjects (compared to control subjects), and the least activation during melody perception, which was the most difficult task for CI users. These results may suggest a possible relationship between auditory performance and degree of auditory cortical activation in implant recipients that deserves further study.
Limb
Charles J
CJ
NIDCD/NIH, Language Section, 10 Center Drive, Rockville, MD 20892, USA. climb@jhmi.edu
Molloy
Anne T
AT
Jiradejvong
Patpong
P
Braun
Allen R
AR
D000161:Acoustic Stimulation; D000328:Adult; D001303:Auditory Cortex / Q000000981:diagnostic imaging / Q000502:physiology; D003054:Cochlear Implants; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009146:Music; D049268:Positron-Emission Tomography; D013067:Speech Perception / Q000502:physiology*; D013998:Time Perception / Q000502:physiology*; D055815:Young Adult