title: Contrast sensitivity and tear layer aberrometry in dry eye patients.
abstract: OBJECTIVE
  Dry eye disease is a common condition that affects millions of people world wide. The common findings of dry eye disease are blurred vision and tear film instability. The purpose of this study was to determine if long-term use of artificial tears altered visual disturbances and tear film instability of dry eye patients.
  
  
  METHODS
  Contrast sensitivity and optical aberrations were measured in 22 dry eye and 10 normal patients before and after daily use of artificial tears. The contrast sensitivity and optical aberrations were measured in response to the administration of a single drop of artificial tear placed in the eye.
  
  
  RESULTS
  The short-term effect (i.e., a few minutes) of a single drop of artificial tear placed in the eye was a decrease in contrast sensitivity and an increase in optical aberrations. Long-term daily use of the artificial tears (i.e., up to 2 weeks) resulted in less of a short-term effect in dry eye patients. No long-term effect was observed for normal subjects. Both contrast sensitivity loss and optical aberrations decreased by 35% per week of artificial tear use for the dry eye patients suggesting that the changes in contrast sensitivity were the result of optical aberrations.
  
  
  CONCLUSIONS
  The results suggest that the changes in contrast sensitivity with artificial tear administration were the result of optical aberrations. It appears that long-term use of artificial tears may normalize the tear layer of dry eye disease patients.
authors: Department of Basic and Visual Science, Southern California College of Optometry, Fullerton, California 92831, USA. wridder@scco.edu
authors: William H
authors: WH
authors: Ridder
authors: James
authors: J
authors: LaMotte
authors: Jonathan Q
authors: JQ
authors: Hall
authors: Robin
authors: R
authors: Sinn
authors: Andrew Loc
authors: AL
authors: Nguyen
authors: Leila
authors: L
authors: Abufarie
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D015350:Contrast Sensitivity / Q000187:drug effects; D003315:Cornea / Q000187:drug effects; D019781:Corneal Topography; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions / Q000008:administration & dosage*; D011795:Surveys and Questionnaires; D013666:Tears / Q000378:metabolism*; D016896:Treatment Outcome; D014985:Xerophthalmia / Q000175:diagnosis* / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology*; D055815:Young Adult
chemical_list: D009883:Ophthalmic Solutions