[Correlation between serum MMP-2 and MMP-9 in patients with acute myocardial infarction before and after PCI].
OBJECTIVE
To investigate the correlation between serum MMP-2 and MMP-9 in patients with acute myocardial infarction (AMI) before and after PCI.


METHODS
The enzymatic activity and protein expression level of serum MMP-2 and MMP-9 in 56 patients with AMI and 20 control subjects were detected by the SDS-PAGE enzymograph and Western blot before and 1-7 days after PCI. The correlation between MMP-2 and MMP-9 was also analyzed.


RESULTS
The enzymatic activity and protein expression level of serum MMP-2 and MMP-9 in 56 patients with AMI were both significantly higher than those in the control subjects before and after PCI (P<0.01). The enzymatic activity and protein expression level of serum MMP-2 and MMP-9 in patients with AMI began to increase on the first day and were at peak on the third day (P<0.01). They began to decrease on the fifth day after PCI (P<0.05). The enzymatic activity of serum MMP-2 was correlated positively with that of MMP-9 (P<0.01). The protein expression level of serum MMP-2 was also correlated positively with that of MMP-9 (P<0.01).


CONCLUSIONS
The serum MMP-2 and MMP-9 may be related to inflammatory injuries after myocardial ischemia and reperfusion. MMP-2 can be regarded as an important marker of inflammation as MMP-9 in the pathogenesis of AMI.
Dai
Feng
F
Department of Emergency, Xiangya Hospital, Central South University, Changsha 410008, China. daifeng1999@126.com
Xiao
Gui-lin
GL
Pan
Jing
J
D000328:Adult; D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000097:blood* / Q000235:genetics; D020780:Matrix Metalloproteinase 9 / Q000097:blood* / Q000235:genetics; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000201:enzymology* / Q000235:genetics / Q000601:surgery*
D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9