Liver X receptor expression in human melanocytes, does it have a role in the pathogenesis of vitiligo?
Vitiligo is a common, non-contagious disorder. The basic pathogenesis of vitiligo generally, or for any of the putative subsets of vitiligo, remains unknown. The liver X receptors (LXRs), LXR-alpha and LXR-beta are members of the nuclear hormone receptor superfamily of ligand-activated transcription factors. Important genes involved in regulation of melanocytes are target genes of LXRs; it can be speculated that LXRs might be playing an important role in pathogenesis of pigmentary disorders. We have demonstrated in this study that there is expression of LXR-alpha/beta by human melanocytes at both transcriptional and translational levels. Our present data also revealed that the expression of LXR-alpha at both mRNA and protein level was significantly higher in perilesional skin as compared to the normal skin of vitiligo patient.
Kumar
Ravinder
R
Parsad
Davinder
D
Kaul
Deepak
D
Kanwar
Amrinderjit J
AJ
Kanwar
Amrinderjit
A
D002478:Cells, Cultured; D006801:Humans; D000071518:Liver X Receptors; D008544:Melanocytes / Q000378:metabolism*; D057093:Orphan Nuclear Receptors / Q000378:metabolism*; D014820:Vitiligo / Q000209:etiology / Q000378:metabolism*
D000071518:Liver X Receptors; C000605213:NR1H3 protein, human; D057093:Orphan Nuclear Receptors