Total synthesis and structure revision of the (-)-maduropeptin chromophore.
The proposed structure of the maduropeptin chromophore, the biologically active component of the highly potent chromoprotein antitumor antibiotics, was stereoselectively synthesized but did not satisfy the spectra of the natural product. We demonstrated that the correct structure is diastereomeric, which possesses an antipodal sugar moiety.
Komano
Kazuo
K
Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan.
Shimamura
Satoshi
S
Norizuki
Yutaro
Y
Zhao
Donglin
D
Kabuto
Chizuko
C
Sato
Itaru
I
Hirama
Masahiro
M
D053281:Enediynes / Q000138:chemical synthesis* / Q000737:chemistry*
D053281:Enediynes; C509891:maduropeptin enediyne