[Effects of quercetin on the expression of VEGF-C and VEGFR-3 in human cancer MGC-803 cells].
OBJECTIVE
To investigate the mechanism of quercetin on the inhibition of the lymphatic metastasis in human gastric cancer cells MGC-803.


METHODS
Cells were divided into the control group and the quercetin (Que)-treated group. Immunohistochemistry and RT-PCR were used to detect the expression of vascular endothelial growth factor C (VEGF-C) and VEGFR-3 of human gastric cancer cells MGC-803 in response to Que.


RESULTS
Que significantly decreased the expression of VEGF-C and VEGFR-3 at 40 mumol/L compared with the control group after 48 h (P<0.01).


CONCLUSIONS
Que can down-regulate the expression of VEGF-C and VEGFR-3 in human gastric cancer cells MGC-803.
Yu
Zhi-jun
ZJ
Institute of Cellular and Molecular Biology, College of Medical Science, Wuhan University of Science and Technology, Wuhan 430065, China.
He
Li-ya
LY
Chen
Yong
Y
Wu
Mian-yun
MY
Zhao
Xue-hua
XH
Wang
Zhen-yu
ZY
D045744:Cell Line, Tumor; D015536:Down-Regulation / Q000187:drug effects*; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D006801:Humans; D011794:Quercetin / Q000494:pharmacology*; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism; D042582:Vascular Endothelial Growth Factor C / Q000235:genetics* / Q000378:metabolism; D040321:Vascular Endothelial Growth Factor Receptor-3 / Q000235:genetics* / Q000378:metabolism
D042582:Vascular Endothelial Growth Factor C; D011794:Quercetin; D040321:Vascular Endothelial Growth Factor Receptor-3