title: New antitumour fungal metabolites from Alternaria porri.
abstract: Chemical investigation of the onion pathogenic fungus Alternaria porri resulted in the isolation of two new phthalides named zinnimide (2) and deprenylzinnimide (8), along with a new bianthraquinone, alterporriol F (10). The structures of the new metabolites were characterised by spectroscopic analysis and chemical degradation. Of the new compounds isolated, alterporriol F was highly cytotoxic towards HeLa and KB cells, with IC(50) values of 6.5 and 7.0 microg mL(-1).
authors: Natural Products Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand. preecha.p@chula.ac.th
authors: Preecha
authors: P
authors: Phuwapraisirisan
authors: Jakaphan
authors: J
authors: Rangsan
authors: Pongpan
authors: P
authors: Siripong
authors: Santi
authors: S
authors: Tip-Pyang
mesh_terms: D000528:Alternaria / Q000737:chemistry* / Q000378:metabolism; D000880:Anthraquinones / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D001572:Benzofurans / Q000737:chemistry / Q000494:pharmacology; D003124:Colorimetry / Q000379:methods; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D007624:KB Cells / Q000187:drug effects; D007783:Lactones / Q000737:chemistry / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010795:Phthalic Acids / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000880:Anthraquinones; D000970:Antineoplastic Agents; D001572:Benzofurans; D007783:Lactones; D010795:Phthalic Acids; C032279:phthalic acid; C082022:phthalide; C005197:alternariol