Recurrent keratoacanthoma with vascular invasion: a diagnostic and management dilemma.
A 71-year-old man with chronic renal failure and on peritoneal dialysis presented with recurrence of multiple keratotic nodules along a surgical scar. This was 6 months after the excision of a recurrent keratotic nodule reported as squamous cell carcinoma from the same site. The lesions were initially reported as squamous cell carcinomas, but on review of histology were consistent with keratoacanthomas. One of the keratoacanthomas showed vascular invasion. These responded well to low-dose acitretin at 10 mg three times per week and the patient stayed in remission after 18 months of follow up.
Kurien
Anil
A
Department of Dermatology, Liverpool Hospital, Sydney, New South Wales, Australia. akurien@bigpond.net.au
Henderson
Christopher
C
Lee
Simon
S
D017255:Acitretin / Q000627:therapeutic use*; D000368:Aged; D001707:Biopsy, Needle; D001808:Blood Vessels / Q000473:pathology; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D007636:Keratoacanthoma / Q000473:pathology* / Q000601:surgery; D007676:Kidney Failure, Chronic / Q000175:diagnosis / Q000628:therapy; D007717:Knee; D008297:Male; D009361:Neoplasm Invasiveness / Q000473:pathology*; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy* / Q000473:pathology; D009367:Neoplasm Staging; D010530:Peritoneal Dialysis; D018570:Risk Assessment; D012878:Skin Neoplasms / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome
D017255:Acitretin