title: Isolation of 1',3'-dilinolenoyl'-2'-linoleoylglycerol with tyrosinase inhibitory activity from Flammulina velutipes.
abstract: This study was carried out to evaluate the inhibitory effect of Flammulina velutipes extracts on tyrosinase activity and to identify its biologically active component. The ethyl acetate and n-butanol extracts showed potent tyrosinase inhibitory activities. Subsequently, fractions of the nbutanol extract showed only a partial tyrosinase inhibitory activity. The most active compound of tyrosinase inhibitory activity was identified from the ethyl acetate extract as 1',3'-dilinolenoyl-2'-linoleoylglycerol (LnLLn) by comparing its mass, 1H-, and 13C-NMR spectral data with those previously reported in the literature. LnLLn showed tyrosinase inhibitory activity with an IC50 value of 16.1 mug/ml. These results suggest that the ethyl acetate extract of F. velutipes could be applicable for the development of a new whitening agent.
authors: Department of Bioindustry and Technology, Sangji University, Wonju, Korea.
authors: Se-Gul
authors: SG
authors: Jang
authors: Kyung-Su
authors: KS
authors: Jeon
authors: Eun-Hee
authors: EH
authors: Lee
authors: Won-Sik
authors: WS
authors: Kong
authors: Jae-Yong
authors: JY
authors: Cho
mesh_terms: D055393:Flammulina / Q000737:chemistry*; D048690:Fruiting Bodies, Fungal / Q000737:chemistry; D007218:Industrial Microbiology; D009682:Magnetic Resonance Spectroscopy; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors*; D014280:Triglycerides / Q000737:chemistry* / Q000302:isolation & purification*
chemical_list: C544957:1',3'-dilinolenoyl-2'-linoleoylglycerol; D014280:Triglycerides; D014442:Monophenol Monooxygenase