Psoriasis induced or aggravated by drugs.
Drug ingestion may result in exacerbation of preexisting psoriasis, induction of psoriatic lesions on clinically uninvolved skin in patients with psoriasis, or precipitation of the disease. In view of their relationship to psoriasis, therapeutic agents may be classified as follows: (1) drugs with strong evidence for a causal relationship to psoriasis including lithium, beta blockers, and synthetic antimalarial drugs; (2) drugs with considerable number of studies but insufficient data to support induction or aggravation of the disease; (3) drugs occasionally reported to be associated with aggravation or induction. While focusing on the most common causative agents for drug induced/aggravated psoriasis, we discuss the controversies about the relationship between drugs and psoriasis and report our own experience at the Section of Dermatology, University of Genoa.
Rongioletti
Franco
F
Section of Dermatology, DISEM, University of Genoa, 16132, Genova, Italy. franco.rongioletti@unige.it
Fiorucci
Cristina
C
Parodi
Aurora
A
D000305:Adrenal Cortex Hormones / Q000009:adverse effects; D000319:Adrenergic beta-Antagonists / Q000009:adverse effects; D000962:Antimalarials / Q000009:adverse effects; D006801:Humans; D018020:Lithium Compounds / Q000009:adverse effects; D011565:Psoriasis / Q000139:chemically induced*
D000305:Adrenal Cortex Hormones; D000319:Adrenergic beta-Antagonists; D000962:Antimalarials; D018020:Lithium Compounds