title: Presence of vulnerable coronary plaques in middle-aged individuals who suffered a brain death.
abstract: OBJECTIVE
  Vulnerable plaques in coronary arteries are frequently found in individuals who died suddenly or due to an acute coronary syndrome. The prevalence and characteristics of these plaques in the middle-aged apparently healthy population are unknown.
  
  
  RESULTS
  From a total of 652 hearts from transplant donors collected between 1996 and 2007, we selected those from apparently healthy individuals older than 40 years old who died of head trauma or stroke and had no evidence of prior vascular diseases. The coronary arteries were examined by serial sectioning at 3 mm intervals, and all areas of cross-sectional luminal narrowing were processed for histological, immunohistochemical, and morphometric studies. The atherosclerotic plaques were classified according to the American Heart Association Report. A total of 160 hearts were examined. Mean age was 50.3 +/- 5.8 years. Sixty-eight hearts had no advanced coronary atherosclerotic lesions (Type I, II, and III of the American Heart classification). In the remaining 92 hearts, we found 179 plaques considered high-risk lesions (American Heart Association Type IV, V, and VI). These plaques were more frequently found in males (P < 0.001) and in those with a higher heart weight (P < 0.001). The median (25th and 75th percentiles) vascular narrowing value using a planimetric analysis was 32% (21-53). No significant association with the cause of death was found (P = 0.09).
  
  
  CONCLUSIONS
  High-risk coronary artery plaques not associated with significant vascular lumen reduction exist in 57% of patients who suffered a brain death with a mean of 1.11 lesions prone to rupture per individual.
authors: Department of Cardiovascular Medicine Fundacion Favaloro, and Consejo Nacional de Investigaciones Científicas y Técnicas, CONICET, Buenos Aires, Argentina. epgurfinkel@ffavaloro.org
authors: Enrique
authors: E
authors: Gurfinkel
authors: Carlos
authors: C
authors: Vigliano
authors: Julieta Vera
authors: JV
authors: Janavel
authors: Diego
authors: D
authors: Fornoni
authors: Gaspar
authors: G
authors: Caponi
authors: Patricia Cabeza
authors: PC
authors: Meckert
authors: Alejandro
authors: A
authors: Bertolotti
authors: Roberto
authors: R
authors: Favaloro
authors: Ruben
authors: R
authors: Laguens
mesh_terms: D000328:Adult; D001930:Brain Injuries / Q000473:pathology*; D003324:Coronary Artery Disease / Q000145:classification / Q000209:etiology / Q000473:pathology*; D003328:Coronary Thrombosis / Q000473:pathology; D003331:Coronary Vessels / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020521:Stroke / Q000473:pathology*