Hydrodynamic effects on the translocation rate of a polymer through a pore.
The translocation of large DNA molecules through narrow pores has been examined in the context of multiscale simulations that include a full coupling of fluctuating hydrodynamic interactions, boundary effects, and molecular conformation. The actual rate constants for this process are determined for the first time, and it is shown that hydrodynamic interactions can lead to translocation rates that vary by multiple orders of magnitude when molecular weights are only changed by a factor of 10, in stark contrast to predictions from widely used free draining calculations.
Hernández-Ortiz
Juan P
JP
Departamento de Materiales, Universidad Nacional de Colombia, Sede Medellín, Kra 80 No. 65-223, Bloque M3-050 Medellín, Colombia. jphernandezo@unalmed.edu.co
Chopra
Manan
M
Geier
Stephanie
S
de Pablo
Juan J
JJ
D001692:Biological Transport; D003198:Computer Simulation; D004247:DNA / Q000737:chemistry*; D007700:Kinetics; D011108:Polymers / Q000737:chemistry*; D016062:Porosity
D011108:Polymers; D004247:DNA