title: Atopic disease and risk of non-Hodgkin lymphoma: an InterLymph pooled analysis.
abstract: We performed a pooled analysis of data on atopic disease and risk of non-Hodgkin lymphoma (NHL) from 13 case-control studies, including 13,535 NHL cases and 16,388 controls. Self-reported atopic diseases diagnosed 2 years or more before NHL diagnosis (cases) or interview (controls) were analyzed. Pooled odds ratios (OR) and 95% confidence intervals (95% CI) were computed in two-stage random-effects or joint fixed-effects models, and adjusted for age, sex, and study center. When modeled individually, lifetime history of asthma, hay fever, specific allergy (excluding hay fever, asthma, and eczema), and food allergy were associated with a significant reduction in NHL risk, and there was no association for eczema. When each atopic condition was included in the same model, reduced NHL risk was only associated with a history of allergy (OR, 0.80; 95% CI, 0.68-0.94) and reduced B-cell NHL risk was associated with history of hay fever (OR, 0.85; 95% CI, 0.77-0.95) and allergy (OR, 0.84; 95% CI, 0.76-0.93). Significant reductions in B-cell NHL risk were also observed in individuals who were likely to be truly or highly atopic-those with hay fever, allergy, or asthma and at least one other atopic condition over their lifetime. The inverse associations were consistent for the diffuse large B-cell and follicular subtypes. Eczema was positively associated with lymphomas of the skin; misdiagnosis of lymphoma as eczema is likely, but progression of eczema to cutaneous lymphoma cannot be excluded. This pooled study shows evidence of a modest but consistent reduction in the risk of B-cell NHL associated with atopy.
authors: University of New South Wales Cancer Research Center, Prince of Wales Clinical School and National Center in HIV Epidemiology and Clinical Research, University of New South Wales, and Prince of Wales Hospital, Randwick, New South Wales, Australia. claire.vajdic@unsw.edu.au
authors: Claire M
authors: CM
authors: Vajdic
authors: Michael O
authors: MO
authors: Falster
authors: Silvia
authors: S
authors: de Sanjose
authors: Otoniel
authors: O
authors: Martínez-Maza
authors: Nikolaus
authors: N
authors: Becker
authors: Paige M
authors: PM
authors: Bracci
authors: Mads
authors: M
authors: Melbye
authors: Karin Ekström
authors: KE
authors: Smedby
authors: Eric A
authors: EA
authors: Engels
authors: Jennifer
authors: J
authors: Turner
authors: Paolo
authors: P
authors: Vineis
authors: Adele Seniori
authors: AS
authors: Costantini
authors: Elizabeth A
authors: EA
authors: Holly
authors: Eleanor
authors: E
authors: Kane
authors: John J
authors: JJ
authors: Spinelli
authors: Carlo
authors: C
authors: La Vecchia
authors: Tongzhang
authors: T
authors: Zheng
authors: Brian C-H
authors: BC
authors: Chiu
authors: Luigino
authors: L
authors: Dal Maso
authors: Pierluigi
authors: P
authors: Cocco
authors: Marc
authors: M
authors: Maynadié
authors: Lenka
authors: L
authors: Foretova
authors: Anthony
authors: A
authors: Staines
authors: Paul
authors: P
authors: Brennan
authors: Scott
authors: S
authors: Davis
authors: Richard
authors: R
authors: Severson
authors: James R
authors: JR
authors: Cerhan
authors: Elizabeth C
authors: EC
authors: Breen
authors: Brenda
authors: B
authors: Birmann
authors: Wendy
authors: W
authors: Cozen
authors: Andrew E
authors: AE
authors: Grulich
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000150:complications / Q000453:epidemiology*; D008228:Lymphoma, Non-Hodgkin / Q000453:epidemiology* / Q000209:etiology*; D008297:Male; D015201:Meta-Analysis as Topic; D008875:Middle Aged; D012307:Risk Factors; D055815:Young Adult