title: [Analysis of relation between structure and antibiotic activity of Batumin].
abstract: Antimicrobial activity of six derivatives and products of chemical modification of antistaphylococcal antibiotic Batumin and one natural analog of this antibiotic formed by the strain-producer has been investigated. Not a single substance, which could exceed Batumin or be equal to it as to activity and selectivity in respect of staphylococci was detected among the studied compounds. It was shown that a unique antimicrobial effect of Batumin was determined by several peculiarities of its molecule: presence of double bonds, group--CONH2, as well as carboxyl and hydroxyl groups. The substitution or modification of each of these groups decreased activity against staphylococci and qualitatively changed antimicrobial spectrum of the antibiotic.
authors: E A
authors: EA
authors: Kiprianova
authors: V V
authors: VV
authors: Klochko
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009930:Organic Chemicals / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D011549:Pseudomonas / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D009930:Organic Chemicals; C088306:batumin