CCR2-64I allele is associated with the progression of AIDS in a Han Chinese population.
It has been reported that the CCR5-Delta32, CCR2-64I and SDF1-3'A polymorphisms have protective effects against HIV-1 infection and can delay the progression of AIDS in European populations. The aim of this study was to investigate the associations of the three loci with HIV-1 infection and the progression of AIDS in the Han population of northern China. We recruited 78 HIV-1-seropositive individuals and 70 population-matched healthy controls from north China. PCR-RFLP was used to genotype these three polymorphisms in all samples. There were no significant differences in the frequencies of any allele between HIV-1-seropositive individuals and healthy controls. In cases, the associations between the three loci and CD4(+) T-lymphocyte counts were not significant; however, there was a significant association between the genotype frequency of CCR2-64I and clinical category (P < 0.05). We have identified a potentially important role of CCR2-64I allele in AIDS progression in the northern Chinese population. Further studies are necessary to clarify the contribution of the CCR2-64I allele to the progression of AIDS for the relatively small sample size.
Xu
Lidan
L
Laboratory of Medical Genetics, Harbin Medical University, Harbin, China.
Qiao
Yuandong
Y
Zhang
Xuelong
X
Sun
Haiming
H
Wang
Jingwei
J
Sun
Donglin
D
Jin
Yan
Y
Yu
Yang
Y
Chen
Feng
F
Bai
Jing
J
Ling
Hong
H
Wang
Kaili
K
Fu
Songbin
S
D000163:Acquired Immunodeficiency Syndrome / Q000235:genetics*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D018450:Disease Progression; D005006:Ethnicity / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D008875:Middle Aged; D055815:Young Adult