Effective treatment of intractable skin ulcers using allogeneic cultured dermal substitutes in patients with systemic lupus erythematosus.
Skin ulcers in systemic lupus erythematosus (SLE) patients are non-healing or intractable, because various factors or complications, including vasculitis and immunosuppressants, impair wound healing. In the present study, we applied cultured dermal substitutes (CDSs) to 3 cases of SLE skin ulcers because various systemic or topical therapies were ineffective. CDSs are prepared by culturing human fibroblasts on two-layered spongy matrices of hyaluronic acid and atelo-collagen, and they effectively promote the healing of severe skin defects. After using CDSs in the 3 cases, healthy granulation tissues formed within 6 weeks, and skin grafts were successfully performed. These results indicate that allogeneic CDSs provide new therapeutic alternatives as topical therapies for intractable skin ulcers in SLE.
Toyozawa
Seiko
S
Department of Dermatology, School of Medicine, Wakayama Medical University, 811-1, Kimiidera, Wakayama, Japan. seikotoy@wakayama-med.ac.jp
Yamamoto
Yuki
Y
Kishioka
Akiko
A
Yonei
Nozomi
N
Kanazawa
Nobuo
N
Matsumoto
Yasuhiro
Y
Kuroyanagi
Yoshimitsu
Y
Furukawa
Fukumi
F
D000328:Adult; D000368:Aged; D005260:Female; D005347:Fibroblasts / Q000166:cytology; D006801:Humans; D007866:Leg / Q000473:pathology; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000473:pathology / Q000601:surgery*; D012720:Severity of Illness Index; D016038:Skin Transplantation; D012883:Skin Ulcer / Q000209:etiology / Q000473:pathology / Q000601:surgery*; D023822:Tissue Engineering / Q000379:methods*; D014184:Transplantation, Homologous; D014945:Wound Healing