title: Homeopathic treatment of minor aphthous ulcer: a randomized, placebo-controlled clinical trial.
abstract: OBJECTIVE
  The objectives of this study were to clinically determine the efficacy of individualised homeopathy in the treatment of minor recurrent aphthous ulceration (MiRAU).
  
  
  METHODS
  A randomized, single blind, placebo-controlled clinical trial of individualised homeopathy. One hundred patients with minor aphthous ulcer were treated with individualised homeopathic medicines or placebo and followed up for 6 days. Patients received two doses of individualised homeopathic medicines in the 6C potency as oral liquid at baseline and 12 h later. Pain intensity and ulcer size were recorded at baseline during and at the end of the trial (mornings of days 4 and 6).
  
  
  RESULTS
  All 100 patients completed treatment. Between group differences for pain intensity and ulcer size were statistically significant at day 4 and at day 6 (P<0.05). No adverse effects were reported.
  
  
  CONCLUSIONS
  The results suggest that homeopathic treatment is an effective and safe method in the treatment of MiRAU.
authors: Department of Oral Medicine, Tehran University of Medical Sciences, Dental School, Tehran, Iran.
authors: Fahimeh
authors: F
authors: Mousavi
authors: Yalda Nozad
authors: YN
authors: Mojaver
authors: Mehdi
authors: M
authors: Asadzadeh
authors: Mustafa
authors: M
authors: Mirzazadeh
mesh_terms: D000328:Adult; D004305:Dose-Response Relationship, Drug; D005260:Female; D006705:Homeopathy / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D008517:Phytotherapy / Q000379:methods*; D016037:Single-Blind Method; D013281:Stomatitis, Aphthous / Q000150:complications / Q000188:drug therapy*; D016896:Treatment Outcome