title: Clinical course and predictors of death in prosthetic valve endocarditis over a 20-year period.
abstract: OBJECTIVE
  To compare early and late outcome of patients with prosthetic valve endocarditis treated medically versus surgically and to determine predictors of in-hospital death. We retrospectively reviewed patient's clinical records, including laboratory findings, surgery, and pathologic files, in an acute-care, 1200-bed teaching hospital.
  
  
  METHODS
  One hundred thirty-three episodes of definite prosthetic valve endocarditis as defined by the Duke University diagnostic criteria occurred in 122 patients from January 1986 to December 2005. Logistic regression model was used to identify prognostic factors of in-hospital mortality. Long-term follow-up was made to assess late prognosis.
  
  
  RESULTS
  Bioprostheses were involved in 52% of cases and mechanical valves in 48%. The aortic valve was affected in 45% of patients. Staphylococcus epidermidis was isolated in 23% of cases, Streptococcus spp in 21%, S aureus in 13%, and Enterococcus in 8%. Cultures were negative in 18% of cases. Twenty-six patients were treated medically and 107 with combined antibiotics and valve replacement. The operative mortality was 6.5% and the in-hospital mortality, 29%. Presence of an abscess at echocardiography, urgent surgical treatment, heart failure, thrombocytopenia, and renal failure were significant predictors of in-hospital death. Kaplan-Meier survival at 12 months was 42% in patients treated medically and 71% in those treated surgically (P = .0007). Freedom from endocarditis was 91% at the end of follow-up.
  
  
  CONCLUSIONS
  Prosthetic valve endocarditis is a serious condition with high mortality. Patients with perivalvular abscess had a worse prognosis, and combined surgical and medical treatment could be the preferred approach to improve outcome.
authors: Emergency Department, Hospital Universitario Marqués de Valdecilla, Universidad de Cantabria, Santander, Spain.
authors: Hector
authors: H
authors: Alonso-Valle
authors: Concepcion
authors: C
authors: Fariñas-Alvarez
authors: Jose Daniel
authors: JD
authors: García-Palomo
authors: Jose Manuel
authors: JM
authors: Bernal
authors: Rafael
authors: R
authors: Martín-Durán
authors: Jose Francisco
authors: JF
authors: Gutiérrez Díez
authors: Jose Manuel
authors: JM
authors: Revuelta
authors: M Carmen
authors: MC
authors: Fariñas
mesh_terms: D004696:Endocarditis / Q000188:drug therapy / Q000401:mortality* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006350:Heart Valve Prosthesis / Q000382:microbiology*; D017052:Hospital Mortality; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis; D013997:Time Factors; D016896:Treatment Outcome