title: No association of alcohol dependence with SLC6A5 and SLC6A9 glycine transporter polymorphisms.
abstract: To determine whether glycine transporter polymorphisms are associated with alcoholism, three genetic variants of SLC6A5 and two polymorphisms of SLC6A9 were genotyped in 463 German non-alcoholic controls and 644 German alcohol-dependent subjects. Association was investigated employing chi-square statistics and haplotype analysis. There was a significant association between the SLC6A5 polymorphism (rs1443547) and alcohol dependence as alcoholic individuals had a lower rate of AG-allele (chi(2) = 6.048, P = 0.049, d.f. = 2), which did not remain significant after correction for multiple testing. There was no association between SLC6A9 glycine transporter polymorphisms and alcohol dependence, and also none in haplotype analysis.
authors: Psychiatrische Klinik, Nussbaumstrasse 7, 80336 Munich, Germany. gabi.koller@med.uni-muenchen.de
authors: Gabriele
authors: G
authors: Koller
authors: Peter
authors: P
authors: Zill
authors: Christoph
authors: C
authors: Fehr
authors: Oliver
authors: O
authors: Pogarell
authors: Brigitta
authors: B
authors: Bondy
authors: Michael
authors: M
authors: Soyka
authors: Ulrich-Wilkelm
authors: UW
authors: Preuss
mesh_terms: D000437:Alcoholism / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D014644:Genetic Variation / Q000235:genetics; D005838:Genotype; D050487:Glycine Plasma Membrane Transport Proteins / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D015995:Prevalence; D012720:Severity of Illness Index
chemical_list: D050487:Glycine Plasma Membrane Transport Proteins; C493271:SLC6A5 protein, human; C493268:SLC6A9 protein, human