title: Surveillance following orchiectomy for stage I testicular seminoma: long-term outcome.
abstract: OBJECTIVE
  To report the long-term outcome of surveillance for stage I seminoma at a single institution in Japan.
  
  
  METHODS
  A retrospective review of medical records of 64 patients who underwent orchiectomy between January 1982 and December 2005 was carried out. All of them were managed by surveillance for stage I seminoma.
  
  
  RESULTS
  Median follow-up time was 123.8 months. Of the 64 patients, seven developed relapse. Four relapses occurred within the first year after orchiectomy, but three occurred over 4 years after orchiectomy. The actuarial relapse-free rates at 5, 10, and 15 years were 92.1%, 90.0%, and 86.0%, respectively. All patients received salvage chemotherapy at relapse. Four of these seven patients were alive without evidence of disease. One patient died of seminoma and one was alive with this disease. The remaining one patient died of leukemia without secondary relapse of seminoma. T classification was a statistically significant (P = 0.028) risk factor for relapse on univariate analysis. In T1 patients, relapse-free rates at 5, 10, and 15 years were all 97.1%, whereas in T2/T3 patients the corresponding relapse-free rates were 86.4%, 82.1%, and 71.8%, respectively.
  
  
  CONCLUSIONS
  The relapse-free rate in the present study was similar to previous reports. Late relapse should be considered during surveillance.
authors: Department of Urology, Osaka Medical Center for Cancer and Cardiovascular diseases, Osaka City, Osaka, Japan. takahiro-y@sannet.ne.jp
authors: Takahiro
authors: T
authors: Yoshida
authors: Ken-ichi
authors: K
authors: Kakimoto
authors: Kentaro
authors: K
authors: Takezawa
authors: Yasuyuki
authors: Y
authors: Arai
authors: Yutaka
authors: Y
authors: Ono
authors: Norio
authors: N
authors: Meguro
authors: Toshiaki
authors: T
authors: Kinouchi
authors: Kazuo
authors: K
authors: Nishimura
authors: Michiyuki
authors: M
authors: Usami
mesh_terms: D000328:Adult; D000368:Aged; D018572:Disease-Free Survival; D006801:Humans; D007564:Japan; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000601:surgery; D009919:Orchiectomy / Q000009:adverse effects* / Q000706:statistics & numerical data; D011159:Population Surveillance; D012189:Retrospective Studies; D012307:Risk Factors; D018239:Seminoma / Q000145:classification / Q000473:pathology / Q000601:surgery*; D015996:Survival Rate; D013736:Testicular Neoplasms / Q000145:classification / Q000473:pathology / Q000601:surgery*; D016896:Treatment Outcome; D055815:Young Adult