title: The efficacy of Ankaferd Blood Stopper in antithrombotic drug-induced primary and secondary hemostatic abnormalities of a rat-bleeding model.
abstract: Ankaferd comprises a standardized mixture of plants Thymus vulgaris, Glycyrrhiza glabra, Vitis vinifera, Alpinia officinarum and Urtica dioica. Ankaferd Blood Stopper (ABS) as a medicinal product has been approved in the management of external hemorrhage and dental surgery bleedings in Turkey. This study aimed to evaluate the in-vivo hemostatic effect of ABS in rats pretreated with acetylsalicylic acid or enoxaparin. Wistar rats (210-270 g) of both sexes were used in this study. The animals were pretreated with acetylsalicylic acid (10 mg/kg) orally for 4 days or enoxaparin sodium (8 mg/kg) subcutaneously for 3 days or did not receive any anticoagulant before tail cut at 4th day. ABS was administered topically [a total of 4 ml (1 ml/puff x 4)] to the cut tail in the studied animals. The duration of bleeding and the amount of bleeding were measured in order to evaluate the hemostatic effect of ABS. In acetylsalicylic acid-treated animals, topical ABS reduced both the duration and also the amount of bleeding volume by 68.4 and 54.6%, respectively. It was also effective in shortening the duration of bleeding (30.6%) and decreasing the amount of bleeding (32.8%) in enoxaparin-treated animals. ABS, a traditional folkloric medicinal plant extract, has in-vivo hemostatic actions, which may provide a therapeutic potential for the management of patients with deficient hemostasis in the clinical medicine.
authors: Department of Hematology, Faculty of Medicine, University of Fatih, Istanbul, Turkey.
authors: Ali
authors: A
authors: Kosar
authors: Handan S
authors: HS
authors: Cipil
authors: Arif
authors: A
authors: Kaya
authors: Burak
authors: B
authors: Uz
authors: Ibrahim C
authors: IC
authors: Haznedaroglu
authors: Hakan
authors: H
authors: Goker
authors: Oktay
authors: O
authors: Ozdemir
authors: Sevil
authors: S
authors: Ercetin
authors: Serafettin
authors: S
authors: Kirazli
authors: Huseyin Cahit
authors: HC
authors: Firat
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology; D001241:Aspirin / Q000494:pharmacology; D004195:Disease Models, Animal; D017984:Enoxaparin / Q000494:pharmacology; D005260:Female; D006470:Hemorrhage / Q000097:blood* / Q000188:drug therapy* / Q000209:etiology; D006487:Hemostasis / Q000187:drug effects; D006490:Hemostatics / Q000494:pharmacology*; D022125:Lacerations / Q000188:drug therapy; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000925:Anticoagulants; D017984:Enoxaparin; D006490:Hemostatics; D010936:Plant Extracts; C539751:ankaferd blood stopper; D001241:Aspirin