title: Quality of life in treatment-seeking patients with obsessive-compulsive disorder with and without major depressive disorder.
abstract: OBJECTIVE
  To compare the quality of life of patients with obsessive-compulsive disorder (OCD) with and without depression comorbidity.
  
  
  METHODS
  Treatment-seeking outpatients (n = 56) with OCD (n = 28) or comorbid OCD and major depressive disorder (MDD) (n = 28), matched by age, sex, and antidepressant medication use, completed a multidimensional measure of quality of life.
  
  
  RESULTS
  Patients with comorbid OCD and MDD reported significantly greater decrements in their subjective feelings, social relations, and a composite measure of general activities (for example, overall well-being and life satisfaction) in comparison with patients with OCD without MDD. These differences were not owing to the presence of other Axis I comorbid disorders.
  
  
  CONCLUSIONS
  Treatments addressing depression comorbidity in the context of primary OCD are required to improve the quality of life of this severely affected population of OCD sufferers.
authors: Department of Psychiatry, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Ontario.
authors: Stephanie E
authors: SE
authors: Cassin
authors: Margaret A
authors: MA
authors: Richter
authors: K Anne
authors: KA
authors: Zhang
authors: Neil A
authors: NA
authors: Rector
mesh_terms: D000203:Activities of Daily Living / Q000523:psychology; D000328:Adult; D003131:Combined Modality Therapy; D015897:Comorbidity; D003430:Cross-Sectional Studies; D003865:Major Depressive Disorder / Q000453:epidemiology / Q000523:psychology* / Q000628:therapy; D005260:Female; D006785:Hospitals, University; D006801:Humans; D007398:Interpersonal Relations; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000453:epidemiology / Q000523:psychology* / Q000628:therapy; D009864:Ontario; D010342:Patient Acceptance of Health Care / Q000523:psychology*; D010549:Personal Satisfaction; D011788:Quality of Life / Q000523:psychology*