Removal of potassium chloride by nanofiltration from ion-exchanged solution containing potassium clavulanate.
In this study, nanofiltration with NF200 membrane was employed to remove KCl from ion-exchanged solutions containing potassium clavulanate. The pore radius of NF200 membrane was estimated to be around 0.39 nm. The effects of operating pressure on separation performance were investigated in a range of 100-400 psig. The influences of cross-flow velocity (0.14-0.70 cm/s), temperature (4-25 degrees C), and feed composition were also investigated. In all experiments, clavulanate rejection showed high levels from 0.91 to 0.99, while chloride rejection ranged from 0.06 to 0.54. In a case at an operating pressure of 50 psig and 25 degrees C, as much as 94% of clavulanate was retained while 94% of chloride was removed, indicating that NF200 membrane was a suitable choice for selectively removing KCl. NF200 membrane also showed a stable performance in the operational stability test with an ion-exchanged solution obtained by treating actual fermentation broth.
Kim
Hyun Han
HH
Technology and Industry Department, Samsung Economic Research Institute, 1321-15, Seocho 2-dong, Seocho-gu, Seoul 137-955, Korea.
Kim
Jae Hyung
JH
Chang
Yong Keun
YK
D019818:Clavulanic Acid / Q000737:chemistry* / Q000302:isolation & purification; D008567:Membranes, Artificial; D011189:Potassium Chloride / Q000737:chemistry*; D014462:Ultrafiltration / Q000379:methods
D008567:Membranes, Artificial; D019818:Clavulanic Acid; D011189:Potassium Chloride