Non-motor symptoms in atypical and secondary parkinsonism: the PRIAMO study.
The PRIAMO study is a cross-sectional longitudinal observational study aimed at describing epidemiology and evolution of non-motor symptoms (NMS) in patients with different forms of parkinsonism recruited in 55 Italian centres and evaluated over 24 months. In this paper, we are reporting prevalence and clinical characteristics of NMS in patients with atypical and secondary parkinsonism. Out of 1307 consecutive patients with a diagnosis of parkinsonism, 83 patients had vascular parkinsonism (VP), 34 had multiple system atrophy (MSA), 30 had progressive supranuclear palsy (PSP), 14 had dementia with Lewy bodies (DLB) and 11 had corticobasal degeneration (CBD). MSA and DLB had the highest number of NMS domains and symptoms, respectively. Gastrointestinal symptoms, pain, urinary problems and postural instability due to orthostatic hypotension were most frequent in MSA. Sleep disturbances were also common with a prevalence of approximately 70% in all diagnostic groups but CBD (36%). Psychiatric symptoms and attention and memory impairment were frequently observed in all diagnoses but were most prevalent among DLB patients, whereas the prevalence of skin and respiratory disorders was rather low in all forms, ranging between 10 and 30%. Atypical parkinsonism patients also reported a low QoL, with no significant differences among the different forms, whereas PD and VP patients had a better QoL.
Colosimo
Carlo
C
Dipartimento di Scienze Neurologiche, Sapienza Università di Roma, Rome, Italy. carlo.colosimo@uniroma1.it
Morgante
Letterio
L
Antonini
Angelo
A
Barone
Paolo
P
Avarello
Tania P
TP
Bottacchi
Edo
E
Cannas
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A
Ceravolo
Maria Gabriella
MG
Ceravolo
Roberto
R
Cicarelli
Giulio
G
Gaglio
Rosa M
RM
Giglia
Luisa
L
Iemolo
Francesco
F
Manfredi
Michela
M
Meco
Giuseppe
G
Nicoletti
Alessandra
A
Pederzoli
Massimo
M
Petrone
Alfredo
A
Pisani
Antonio
A
Pontieri
Francesco E
FE
Quatrale
Rocco
R
Ramat
Silvia
S
Scala
Rossana
R
Volpe
Giampiero
G
Zappulla
Salvatore
S
Bentivoglio
Anna Rita
AR
Stocchi
Fabrizio
F
Trianni
Giorgio
G
Del Dotto
Paolo
P
Simoni
Lucia
L
Marconi
Roberto
R
D000368:Aged; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007558:Italy / Q000453:epidemiology; D020961:Lewy Body Disease / Q000453:epidemiology; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D019578:Multiple System Atrophy / Q000453:epidemiology; D019636:Neurodegenerative Diseases / Q000453:epidemiology; D010302:Parkinson Disease, Secondary / Q000453:epidemiology*; D020734:Parkinsonian Disorders / Q000453:epidemiology*; D015995:Prevalence; D013494:Supranuclear Palsy, Progressive / Q000453:epidemiology