title: Association of Fas/Apo1 gene promoter (-670 A/G) polymorphism in Tunisian patients with IBD.
abstract: OBJECTIVE
  To detect a possible association between the polymorphism of the (-670 A/G) Fas/Apo1 gene promoter and susceptibility to Crohn's disease (CD) and ulcerative colitis (UC) in the Tunisian population.
  
  
  METHODS
  The (-670 A/G) Fas polymorphism was analyzed in 105 patients with CD, 59 patients with UC, and 100 controls using the polymerase chain reaction restriction fragment length polymorphism method.
  
  
  RESULTS
  Significantly lower frequencies of the Fas -670 A allele and A/A homozygous individuals were observed in CD and UC patients when compared with controls. Analysis of (-670 A/G) Fas polymorphism with respect to sex in CD and UC showed a significant difference in A/A genotypes between female patients and controls (P corrected = 0.004 in CD patients and P corrected = 0.02 in UC patients, respectively). Analysis also showed a statistically significant association between genotype AA of the (-670 A/G) polymorphism and the ileum localization of the lesions (P corrected = 0.048) and between genotype GG and the colon localization (P corrected = 0.009). The analysis of inflammatory bowel disease patients according to clinical behavior revealed no difference.
  
  
  CONCLUSIONS
  Fas-670 polymorphism was associated with the development of CD and UC in the Tunisian population.
authors: Laboratory of Immunology, EPS Charles Nicolle, Bd 9 Avril, 1006 Bab Saadoun, Tunis, Tunisia. b_a_w@hotmail.fr
authors: Walid
authors: W
authors: Ben Aleya
authors: Imen
authors: I
authors: Sfar
authors: Leila
authors: L
authors: Mouelhi
authors: Houda
authors: H
authors: Aouadi
authors: Mouna
authors: M
authors: Makhlouf
authors: Salwa
authors: S
authors: Ayed-Jendoubi
authors: Samira
authors: S
authors: Matri
authors: Azza
authors: A
authors: Filali
authors: Taoufik
authors: T
authors: Najjar
authors: Taeib
authors: T
authors: Ben Abdallah
authors: Khaled
authors: K
authors: Ayed
authors: Yousr
authors: Y
authors: Gorgi
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003093:Colitis, Ulcerative / Q000235:genetics*; D003424:Crohn Disease / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D014416:Tunisia; D055815:Young Adult; D019014:fas Receptor / Q000235:genetics*
chemical_list: D019014:fas Receptor