Anti-allergic effect of a hot-water extract of quince (Cydonia oblonga).
We examined the effect of a crude hot-water extract (HW) of quince (Cydonia oblonga Miller) fruit on type I allergy in vivo and in vitro. The oral administration of the quince HW-added diet to NC/Nga mice for 63 d showed a significant decrease in the development of atopic dermatitis-like skin lesions under conventional conditions. The concentration of IgE in the serum collected from mice fed with quince HW was also lowered in a dose-dependent manner. Moreover, we found that quince HW inhibited the release of beta-hexosaminidase from rat basophilic leukemia cell line RBL-2H3 after a 24-h treatment. The quince HW fraction of less than 3 kDa reduced the mRNA expression of the high-affinity IgE receptor (FcepsilonRI) gamma subunit. These results suggest that quince HW had an inhibitory effect on type I allergy by suppressing IgE production and IgE-mediated degranulation.
Shinomiya
Fumie
F
Laboratory of Food Bioscience, Faculty of Agriculture, Shinshu University, Nagano, Japan.
Hamauzu
Yasunori
Y
Kawahara
Takeshi
T
D000284:Administration, Oral; D000818:Animals; D018926:Anti-Allergic Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D045744:Cell Line, Tumor; D003876:Dermatitis, Atopic / Q000097:blood / Q000188:drug therapy; D006358:Hot Temperature; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D008297:Male; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017455:Receptors, IgE / Q000378:metabolism; D027824:Rosaceae / Q000737:chemistry*; D012867:Skin / Q000187:drug effects / Q000473:pathology; D014867:Water / Q000737:chemistry*; D001619:beta-N-Acetylhexosaminidases / Q000378:metabolism
D018926:Anti-Allergic Agents; D010936:Plant Extracts; D017455:Receptors, IgE; D014867:Water; D007073:Immunoglobulin E; D001619:beta-N-Acetylhexosaminidases