No association between lithium full responders and the DRD1, DRD2, DRD3, DAT1, 5-HTTLPR and HTR2A genes in a Sardinian sample.
Polymorphisms within the DRD1, DRD2, DRD3, DAT1, 5-HTTLPR and HTR2A genes are being studied for association with lithium prophylaxis in a sample of 155 Sardinian unrelated probands affected by bipolar disorder (BP). No significant association was shown between the polymorphisms of the genes studied and response to lithium treatment.
Manchia
Mirko
M
Section of Clinical Pharmacology, Department of Neurosciences "B.B. Brodie", University of Cagliari, P.O. San Giovanni di Dio, Via Ospedale 46, 09124 Cagliari, Italy. mirkomanchia@tiscali.it
Congiu
Donatella
D
Squassina
Alessio
A
Lampus
Simona
S
Ardau
Raffaella
R
Chillotti
Caterina
C
Severino
Giovanni
G
Del Zompo
Maria
M
D000328:Adult; D018692:Antimanic Agents / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000188:drug therapy* / Q000235:genetics*; D050483:Dopamine Plasma Membrane Transport Proteins / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007558:Italy / Q000453:epidemiology / Q000208:ethnology; D018020:Lithium Compounds / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics*; D011954:Receptors, Dopamine / Q000235:genetics*; D017447:Receptors, Dopamine D1 / Q000235:genetics; D017448:Receptors, Dopamine D2 / Q000235:genetics; D050637:Receptors, Dopamine D3 / Q000235:genetics; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D013223:Statistics as Topic
D018692:Antimanic Agents; D050483:Dopamine Plasma Membrane Transport Proteins; D018020:Lithium Compounds; D044402:Receptor, Serotonin, 5-HT2A; D011954:Receptors, Dopamine; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins