title: Induction of apoptotic cell death preferentially in reactive astrocytes by concanavalin A.
abstract: When central nervous system is injured, reactive astrocytes form glial scar which prevents neuronal regeneration. We examined the effects of concanavalin A (ConA) in primary astrocytes, and found preferential apoptotic effect of ConA in migrating reactive astrocytes. Thus, ConA may be applicable for enhancing neuronal regeneration by preventing glial scar.
authors: Department of Epigenetic Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, 409-3898, Japan.
authors: Hideki
authors: H
authors: Yoshida
authors: Kaoru
authors: K
authors: Nagai
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D017209:Apoptosis / Q000187:drug effects*; D001253:Astrocytes / Q000166:cytology*; D002470:Cell Survival; D002478:Cells, Cultured; D003208:Concanavalin A / Q000737:chemistry* / Q000494:pharmacology; D006023:Glycoproteins / Q000737:chemistry; D008358:Mannose / Q000737:chemistry; D009457:Neuroglia / Q000473:pathology; D009474:Neurons / Q000166:cytology / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012038:Regeneration; D013778:Tetrazolium Salts / Q000494:pharmacology; D013844:Thiazoles / Q000494:pharmacology
chemical_list: D006023:Glycoproteins; D013778:Tetrazolium Salts; D013844:Thiazoles; D003208:Concanavalin A; C022616:thiazolyl blue; D008358:Mannose