title: The novel role of platelet-activating factor in protecting mice against lipopolysaccharide-induced endotoxic shock.
abstract: BACKGROUND
  Platelet-activating factor (PAF) has been long believed to be associated with many pathophysiological processes during septic shock. Here we present novel activities for PAF in protecting mice against LPS-mediated endotoxic shock.
  
  
  RESULTS
  In vivo PAF treatment immediately after LPS challenge markedly improved the survival rate against mortality from endotoxic shock. Administration of PAF prominently attenuated LPS-induced organ injury, including profound hypotension, excessive polymorphonuclear neutrophil infiltration, and severe multiple organ failure. In addition, PAF treatment protects against LPS-induced lymphocytes apoptosis. These protective effects of PAF was correlated with significantly decreases in the production of the inflammatory mediators such as TNF-alpha, IL-1beta, IL-12, and IFN-gamma, while increasing production of the anti-inflammatory cytokine IL-10 in vivo and in vitro.
  
  
  CONCLUSIONS
  Taken together, these results suggest that PAF may protect mice against endotoxic shock via a complex mechanism involving modulation of inflammatory and anti-inflammatory mediators.
authors: Department of Microbiology, College of Natural Science, Pusan National University, Geumjeong-Gu, Busan, Korea.
authors: Young-Il
authors: YI
authors: Jeong
authors: In Duk
authors: ID
authors: Jung
authors: Chang-Min
authors: CM
authors: Lee
authors: Jeong Hyun
authors: JH
authors: Chang
authors: Sung Hak
authors: SH
authors: Chun
authors: Kyung Tae
authors: KT
authors: Noh
authors: Soo Kyung
authors: SK
authors: Jeong
authors: Yong Kyoo
authors: YK
authors: Shin
authors: Won Suk
authors: WS
authors: Lee
authors: Mi Sun
authors: MS
authors: Kang
authors: Sang-Yull
authors: SY
authors: Lee
authors: Jae-Dong
authors: JD
authors: Lee
authors: Yeong-Min
authors: YM
authors: Park
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D018836:Inflammation Mediators / Q000378:metabolism; D008070:Lipopolysaccharides / Q000633:toxicity*; D008214:Lymphocytes / Q000187:drug effects; D051379:Mice; D010972:Platelet Activating Factor / Q000008:administration & dosage / Q000494:pharmacology*; D012772:Shock, Septic / Q000378:metabolism / Q000517:prevention & control*
chemical_list: D018836:Inflammation Mediators; D008070:Lipopolysaccharides; D010972:Platelet Activating Factor