title: Comparison of social cognitive functioning in schizophrenia and high functioning autism: more convergence than divergence.
abstract: BACKGROUND
  Individuals with schizophrenia and individuals with high-functioning autism (HFA) seem to share some social, behavioral and biological features. Although marked impairments in social cognition have been documented in both groups, little empirical work has compared the social cognitive functioning of these two clinical groups.
  
  
  METHODS
  Forty-four individuals with schizophrenia, 36 with HFA and 41 non-clinical controls completed a battery of social cognitive measures that have been linked previously to specific brain regions.
  
  
  RESULTS
  The results indicate that the individuals with schizophrenia and HFA were both impaired on a variety of social cognitive tasks relative to the non-clinical controls, but did not differ from one another. When individuals with schizophrenia were divided into negative symptom and paranoid subgroups, exploratory analyses revealed that individuals with HFA may be more similar, in terms of the pattern of social cognition impairments, to the negative symptom group than to the paranoia group.
  
  
  CONCLUSIONS
  Our findings provide further support for similarities in social cognition deficits between HFA and schizophrenia, which have a variety of implications for future work on gene-brain-behavior relationships.
authors: University of North Carolina-Chapel Hill Department of Psychology, NC, USA. scouture@psyc.umd.edu
authors: S M
authors: SM
authors: Couture
authors: D L
authors: DL
authors: Penn
authors: M
authors: M
authors: Losh
authors: R
authors: R
authors: Adolphs
authors: R
authors: R
authors: Hurley
authors: J
authors: J
authors: Piven
mesh_terms: D000328:Adult; D020817:Asperger Syndrome / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008297:Male; D012559:Schizophrenia / Q000175:diagnosis*; D012565:Schizophrenic Psychology; D012720:Severity of Illness Index; D012938:Social Perception; D014888:Wechsler Scales; D055815:Young Adult