Neutrons for biologists: a beginner's guide, or why you should consider using neutrons.
From the structures of isolated protein complexes to the molecular dynamics of whole cells, neutron methods can achieve a resolution in complex systems that is inaccessible to other techniques. Biology is fortunate in that it is rich in water and hydrogen, and this allows us to exploit the differential sensitivity of neutrons to this element and its major isotope, deuterium. Furthermore, neutrons exhibit wave properties that allow us to use them in similar ways to light, X-rays and electrons. This review aims to explain the basics of biological neutron science to encourage its greater use in solving difficult problems in the life sciences.
Lakey
Jeremy H
JH
Institute for Cell and Molecular Biosciences, University of Newcastle, Framlington Place, Newcastle-upon-Tyne NE2 4HH, UK. j.h.lakey@newcastle.ac.uk
D001703:Biophysics / Q000379:methods* / Q000639:trends*; D008967:Molecular Biology / Q000379:methods* / Q000639:trends*; D033363:Neutron Diffraction / Q000379:methods* / Q000639:trends*; D009502:Neutrons