25 years of HIV research! ... and what about a vaccine?
Over the past quarter century, colossal progress in our understanding of HIV pathogenesis has been achieved. Yet, we have no solution to the pandemic; the search for an HIV vaccine remains among the highest public health priorities. Identifying correlates of immune protection in humans, inducing effective immunity through immunization, and overcoming virus and host diversity represent the major obstacles in vaccine development. HIV vaccine research discovery may only be at its dawn.
Appay
Victor
V
INSERM UMR-S 945, Infections and Immunity, Avenir Group, Hôpital Pitié-Salpêtrière, Université Pierre et Marie Curie-Paris6, Paris, France. victor.appay@upmc.fr
D016915:AIDS Vaccines / Q000276:immunology* / Q000627:therapeutic use; D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy / Q000276:immunology* / Q000821:virology; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects / Q000276:immunology; D000998:Antiviral Agents / Q000627:therapeutic use; D035843:Biomedical Research / Q000379:methods / Q000639:trends; D004195:Disease Models, Animal; D015497:HIV-1 / Q000187:drug effects / Q000276:immunology*; D006801:Humans; D008251:Macaca / Q000276:immunology / Q000821:virology; D016097:Simian Acquired Immunodeficiency Syndrome / Q000188:drug therapy / Q000276:immunology / Q000821:virology; D015302:Simian Immunodeficiency Virus / Q000187:drug effects / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*; D016896:Treatment Outcome
D016915:AIDS Vaccines; D000998:Antiviral Agents