title: Regioselective Domino Metathesis of 7-Oxanorbornenes and Its Application to the Synthesis of Biologically Active Glutamate Analogues.
abstract: A highly regioselective domino metathesis reaction of 7-oxanorbornene was developed that employed an intramolecular association of an amide carbonyl group to a ruthenium metal centre. By using this reaction, twelve glutamate analogues inspired by dysiherbaine were efficiently synthesized over 12-14 steps; one of the analogues exhibited bioactivity consistent with central nervous system depression.
authors: Graduate School of Life Sciences, Tohoku University, Aoba-ku, Sendai 981-8555, Japan, , E-mail: mao@bios.tohoku.ac.jp.
authors: Minoru
authors: M
authors: Ikoma
authors: Masato
authors: M
authors: Oikawa
authors: Martin B
authors: MB
authors: Gill
authors: Geoffrey T
authors: GT
authors: Swanson
authors: Ryuichi
authors: R
authors: Sakai
authors: Keiko
authors: K
authors: Shimamoto
authors: Makoto
authors: M
authors: Sasaki