Analysis of transient otoacoustic emissions and brainstem evoked auditory potentials in neonates with hyperbilirubinemia.
Hyperbilirubinemia is toxic to the auditory pathways and to the central nervous system, leaving sequelae such as hearing loss and encephalopathy.


OBJECTIVE
to assess the hearing of neonates with hyperbilirubinemia, using transient evoked otoacoustic emissions (TOAEs) and brainstem evoked auditory potentials (BEAP). Prospective study.


METHODS
we had two groups: GI (n-25), neonates with hyperbilirubinemia; GII (n-22), neonates without hyperbilirubinemia and without risk factors for hearing loss. All the neonates had up to 60 days of life and were submitted to TOAE and BEAP.


RESULTS
12 neonates from GI and 10 from GII were girls and 13 from GI and 12 from GII were boys. TOAEs were present in all the children, however with lower amplitudes in GI, especially in the frequencies of 2 and 3KHz (p < 0.05). Regarding the BEAP, we observed a mild PV and LI-V increase in BI. The alterations observed in these tests do not correlate to the serum levels of bilirubin.


CONCLUSIONS
in neonates with hyperbilirubinemia, we noticed lower TOAE amplitudes and mild PV and LI-V increase, indicating cochlear and retrocochlear disorders, stressing the importance of using both tests and carefully reading them in these evaluations.
Silva
Daniela Polo Camargo da
DP
Bases Gerais da Cirurgia program, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista. daniela-polo@fmb.unesp.br
Martins
Regina Helena Garcia
RH
D016022:Case-Control Studies; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology*; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D051556:Hyperbilirubinemia, Neonatal / Q000150:complications*; D007231:Infant, Newborn; D008297:Male; D015997:Neonatal Screening; D017084:Otoacoustic Emissions, Spontaneous / Q000502:physiology*; D011446:Prospective Studies