title: Enlistment of combinatorial techniques in drug development.
abstract: Combinatorial chemistry, in its ability to generate vast arrays of non-peptide and non-oligonucleotide libraries, has had a major impact on the drug discovery effort. The design and generation of a combinatorial library, coupled with the ever important and effective feedback from high-throughput screening and data management, are critical to any drug discovery process. This review will focus on some aspects of computational chemistry, solid-phase organic chemistry and downstream analysis. The emphasis will be on computational aspects of library design and the use of cyclic scaffolds in the context of a focused library for optimization in drug discovery.
authors: Molecumetics Ltd, Bellevue, WA 98005, USA.
authors: M S
authors: MS
authors: Lee
authors: H
authors: H
authors: Nakanishi
authors: M
authors: M
authors: Kahn