Glucocorticoid or androgen for autoimmune premature ovary failure in mice.
OBJECTIVE
Using mouse autoimmune premature ovary failure (POF) model to seek theoretical evidence for a possible clinical therapy of autoimmune POF with glucocorticoid (GC) or androgen.


METHODS
After autoimmune POF was induced in 60 mice by Pzp3, the mice were randomly assigned into 3 groups (n=20): Two groups were treated with GC or androgen and the control group was treated with distilled water. We observed the changes in the sexual cycles of the mice, the serum level of AzpAb, infiltration of cells positively expressing CD45 in the ovary, and pathological alterations of the ovary.


RESULTS
The sexual cycle of each therapy group was significantly different from that of the control group. The mean serum level of AzpAb of each therapy group was significantly lower than that of the control group, and the mean serum level of AzpAb in the GC group was significantly higher than that of the androgen group. The percentage of growing follicles in the ovary of each therapy group was significantly higher than that of the control group.Ovaries infiltrated by cells positively expressing CD45 of each therapy group were significantly fewer than those of the control group.


CONCLUSIONS
GC or androgen in mice with autoimmune POF could obviously ameliorate the pathogenetic conditions of the disorder, and both treatments have similar therapeutic efficacy.
Shi
Xiaobo
X
Department of Gynaecology and Obstetrics, Second Xiangya Hospital, Central South University, Changsha 410011, China.
Li
Na
N
Liao
Can
C
Shu
Qing
Q
Zhu
Fufan
F
D000728:Androgens / Q000627:therapeutic use*; D000818:Animals; D001327:Autoimmune Diseases / Q000188:drug therapy*; D004195:Disease Models, Animal; D030762:Estrous Cycle / Q000187:drug effects; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D017493:Leukocyte Common Antigens / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D016649:Primary Ovarian Insufficiency / Q000188:drug therapy* / Q000276:immunology*; D011897:Random Allocation
D000728:Androgens; D005938:Glucocorticoids; D017493:Leukocyte Common Antigens