Hepatobiliary abnormalities in pediatric patients with sickle cell disease.
OBJECTIVE
to describe clinical, laboratory and ultrasonographic abnormalities in the hepatobiliary system of pediatric patients with sickle cell disease in the city of Salvador, Brazil.


METHODS
pediatric patients with sickle cell disease were clinically evaluated, their charts were reviewed and findings of supplementary tests were examined to identify hepatobiliary abnormalities.


RESULTS
a total of 134 patients were evaluated, 65 of whom (48.9%) presented hepatomegalia. Elevated transaminases were present in 42.2% and 11.4% presented cholelithiasis. There was a statistically significant association between the presence of hepatomegalia and SS homozygotes and between cholelithiasis and patients over 10 years of age (p = 0.01 and p = 0.00, respectively).


CONCLUSIONS
hepatobiliary abnormalities in patients with sickle cell disease were common, particularly in patients with hemoglobin SS and in adolescent patients.
Almeida
Roberto Paulo
RP
Postgraduate Program in Medicine and Health, Federal University of Bahia, Brasil.
Ferreira
Cibele Dantas
CD
Conceição
Joseni
J
Franca
Rita
R
Lyra
Isa
I
Silva
Luciana Rodrigues
LR
D000293:Adolescent; D000755:Anemia, Sickle Cell / Q000150:complications*; D001660:Biliary Tract Diseases / Q000209:etiology*; D001938:Brazil; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008107:Liver Diseases / Q000209:etiology*