title: Recurrent dysosmia induced by pyrazinamide.
abstract: Pyrazinamide can have adverse effects such as hepatic toxicity, hyperuricemia or digestive disorders. In rare cases, alterations in taste and smell function have been reported for pyrazinamide when combined with other drugs. We report a case of reversible olfactory disorder related to pyrazinamide in a woman, with a positive rechallenge. The patient presented every day a sensation of smelling something burning 15 min after drug intake. Dysosmia disappeared completely after pyrazinamide withdrawal and recurred after its rechallenge. The case was reported to the Tunisian Centre of Pharmacovigilance.
authors: Centre National de Pharmacovigilance, Recueil et Analyse des Effets Indésirables, Tunis, Tunisia.
authors: Sihem
authors: S
authors: El Aïdli
authors: Sarrah
authors: S
authors: Kastalli
authors: Ahmed
authors: A
authors: Zaïem
authors: Ghozlane
authors: G
authors: Lakhoua
authors: Imen
authors: I
authors: Rejeibi
authors: Mohamed Hedi
authors: MH
authors: Loueslati
authors: Riadh
authors: R
authors: Daghfous
authors: Chalbi
authors: C
authors: Belkahia
mesh_terms: D000995:Antitubercular Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008875:Middle Aged; D000857:Olfaction Disorders / Q000139:chemically induced* / Q000175:diagnosis; D011718:Pyrazinamide / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D012008:Recurrence
chemical_list: D000995:Antitubercular Agents; D011718:Pyrazinamide