The clonality of CD3+ CD10+ T cells in angioimmunoblastic T cell lymphoma, B cell lymphoma, and reactive lymphoid hyperplasia.
T cells coexpressing CD3 and CD10 are a characteristic feature of angioimmunoblastic T-cell lymphoma (AITL) [1]. However, they are not unique to AITL, as these cells are also present in B cell lymphoma and reactive lymphoid hyperplasia [2]. To determine the significance of CD3+ CD10+ T cells, we used flow cytometry with cell sorting and molecular biology techniques for T cell gene rearrangement to study T cells from patients with AITL, B cell lymphoma, and reactive lymph node hyperplasia. We found that CD3+ CD10+ T cells in B cell lymphoma and reactive lymphoid hyperplasia were polyclonal. In early stage of AITL, they were oligoclonal, and became monoclonal as AITL progressed. These findings illustrate the differences between early and late lymphoma and could be important for the diagnosis of AITL.
Zhang
Da
D
Saunders
Carol J
CJ
Zhao
Weiwei
W
Davis
Mark
M
Cunningham
Mark T
MT
D002999:Clone Cells; D006801:Humans; D007119:Immunoblastic Lymphadenopathy / Q000473:pathology; D016393:Lymphoma, B-Cell / Q000473:pathology*; D016399:Lymphoma, T-Cell / Q000473:pathology*; D019310:Pseudolymphoma / Q000473:pathology*; D013601:T-Lymphocytes / Q000473:pathology*