Induction of apoptotic cell death preferentially in reactive astrocytes by concanavalin A.
When central nervous system is injured, reactive astrocytes form glial scar which prevents neuronal regeneration. We examined the effects of concanavalin A (ConA) in primary astrocytes, and found preferential apoptotic effect of ConA in migrating reactive astrocytes. Thus, ConA may be applicable for enhancing neuronal regeneration by preventing glial scar.
Yoshida
Hideki
H
Department of Epigenetic Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, 409-3898, Japan.
Nagai
Kaoru
K
D000818:Animals; D000831:Animals, Newborn; D017209:Apoptosis / Q000187:drug effects*; D001253:Astrocytes / Q000166:cytology*; D002470:Cell Survival; D002478:Cells, Cultured; D003208:Concanavalin A / Q000737:chemistry* / Q000494:pharmacology; D006023:Glycoproteins / Q000737:chemistry; D008358:Mannose / Q000737:chemistry; D009457:Neuroglia / Q000473:pathology; D009474:Neurons / Q000166:cytology / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012038:Regeneration; D013778:Tetrazolium Salts / Q000494:pharmacology; D013844:Thiazoles / Q000494:pharmacology
D006023:Glycoproteins; D013778:Tetrazolium Salts; D013844:Thiazoles; D003208:Concanavalin A; C022616:thiazolyl blue; D008358:Mannose