title: Oxytocin deficiency impairs maternal skeletal remodeling.
abstract: We have reported that the posterior pituitary hormone, oxytocin (OT), known for its effects in inducing parturition, lactation and social bonding, is also a skeletal hormone. Here, we demonstrate that OT plays a key role in enabling maternal skeletal mobilization during pregnancy by enhancing the formation of bone resorbing osteoclasts. Osteoclast formation ex vivo is thus diminished in pregnant mothers with genetic OT-deficiency. OT(-/-) pups at day E20 also show a defect in trabecular bone. microCT measurements reveal normal bone volume, but increased trabecular numbers, suggesting that trabeculae in OT(-/-) pups are hypomineralized. We suggest that OT facilitates intergenerational transfer of calcium ions from a pregnant mother to the pups.
authors: Mount Sinai School of Medicine, NY, USA.
authors: Xuan
authors: X
authors: Liu
authors: Kengo
authors: K
authors: Shimono
authors: Ling-Ling
authors: LL
authors: Zhu
authors: Jianhua
authors: J
authors: Li
authors: Yuanzhen
authors: Y
authors: Peng
authors: Aliza
authors: A
authors: Imam
authors: Jameel
authors: J
authors: Iqbal
authors: Surinder
authors: S
authors: Moonga
authors: Graziana
authors: G
authors: Colaianni
authors: Cai
authors: C
authors: Su
authors: Zuhong
authors: Z
authors: Lu
authors: Masahiro
authors: M
authors: Iwamoto
authors: Maurizio
authors: M
authors: Pacifici
authors: Alberta
authors: A
authors: Zallone
authors: Li
authors: L
authors: Sun
authors: Mone
authors: M
authors: Zaidi
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000196:embryology* / Q000378:metabolism; D002113:Calcification, Physiologic / Q000235:genetics / Q000502:physiology*; D020013:Calcium Signaling; D005260:Female; D051379:Mice; D008817:Mice, Mutant Strains; D010010:Osteoclasts / Q000378:metabolism / Q000502:physiology*; D010121:Oxytocin / Q000235:genetics / Q000502:physiology*; D011247:Pregnancy
chemical_list: D010121:Oxytocin