title: [Humoral immune response to dengue virus in mothers/children: relation with Möbius sequence].
abstract: OBJECTIVE
  To investigate the humoral immune response to dengue virus in patients with Möbius sequence and their mothers, assessing the relation between this infection during pregnancy and Möbius sequence.
  
  
  METHODS
  The medical records were reviewed, and a questionnaire was answered by each mother. IgG ELISA was performed in 35 patients and their mothers. A plaque reduction neutralization test was further done in the mothers who reported a viral infection during pregnancy and in their children for determining which dengue serotype virus had caused the infection.
  
  
  RESULTS
  Fever, headache and/or retrobulbar pain during pregnancy was referred by eighteen (51.4%) mothers. Three (8.6%) reported dengue during the first or second quarteers of pregnancy. When cross analyzing the mothers and their respective children serological results, 57.1% of them matched. Of the three mothers with clinical diagnosis of viral infection during pregnancy, one and its respective children had a positive plaque reduction neutralization test for dengue serotype three (DENV-3), this serotype reached Pernambuco in 2002, which excludes the possibility of a vertical transmission to the children.
  
  
  CONCLUSIONS
  The serology of the cases that had clinical diagnosis of dengue during pregnancy proved to be incompatible with the hypothesis of the disease vertical transmission. Therefore, in the present serie, the dengue virus infection can not be considered as a factor involved in the genesis of Möbius sequence.
authors: Fundação Altino Ventura, Recife, PE, Brasil.
authors: Diego Nery Benevides
authors: DN
authors: Gadelha
authors: Bruna Vieira
authors: BV
authors: Ventura
authors: Liana Maria Vieira de Oliveira
authors: LM
authors: Ventura
authors: Marilyn T
authors: MT
authors: Miller
authors: Marli Tenório
authors: MT
authors: Cordeiro
authors: Célia Maria Machado Barbosa de
authors: CM
authors: Castro
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003715:Dengue / Q000175:diagnosis / Q000635:transmission*; D003716:Dengue Virus / Q000276:immunology*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007223:Infant; D018445:Infectious Disease Transmission, Vertical / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D020331:Mobius Syndrome / Q000097:blood / Q000821:virology*; D009035:Mothers / Q000706:statistics & numerical data; D009500:Neutralization Tests; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000097:blood / Q000821:virology*; D055815:Young Adult
chemical_list: D007074:Immunoglobulin G