title: Fulminant Clostridium difficile-associated pouchitis with a fatal outcome.
abstract: Background. A 61-year-old woman who had undergone an ileostomy closure 10 days previously presented to a tertiary medical center with abdominal pain, vomiting, diarrhea, dehydration, and oliguria. The patient had undergone a staged total proctocolectomy with ileal-pouch-anal anastomosis and a loop ileostomy 8 months previously to treat her steroid-refractory ulcerative colitis.Investigations. Physical examination, abdominal and pelvic CT scan, blood laboratory tests, pouch endoscopy, and fecal testing for Clostridium difficle toxins A and B.Diagnosis. Fulminant C. difficile-associated pouchitis and enteritis, which led to Psuedomonas aeruginosa septicemia, intravascular coagulopathy, acute renal failure, hemorrhagic ascites and respiratory failure and eventual death.Management. Intravenous hydration, aggressive therapy with oral and intravenous antibiotics, supportive care, hemodialysis, and intubation.
authors: Digestive Disease Institute, The Cleveland Clinic Foundation, Cleveland, OH, USA.
authors: Bo
authors: B
authors: Shen
authors: Feza H
authors: FH
authors: Remzi
authors: Victor W
authors: VW
authors: Fazio
mesh_terms: D016360:Clostridioides difficile; D003093:Colitis, Ulcerative / Q000601:surgery*; D004761:Enterocolitis, Pseudomembranous / Q000150:complications / Q000473:pathology*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007081:Ileostomy; D008875:Middle Aged; D019449:Pouchitis / Q000150:complications / Q000473:pathology*; D011552:Pseudomonas Infections / Q000150:complications