Spontaneous closure of retinal pigment epithelium microrip in the natural course of central serous chorioretinopathy.
OBJECTIVE
To study the natural course of changes observed in the retinal pigment epithelium (RPE) on spectral domain OCT transverse and RPE fit C-scans corresponding to the leakage point observed on fundus fluorescein angiograms in central serous chorioretinopathy (CSC).


METHODS
Thirteen patients with acute CSC were prospectively enrolled and followed up for 6 months. All were examined using Zeiss Cirrus HD-OCT Model 4000. Transverse and RPE fit C-scans corresponding to point of leakage were superimposed on an OCT fundus photograph and correlated with the leakage point on a fluorescein angiogram. The RPE alterations observed at the leakage point were noted at presentation and follow-up.


RESULTS
Transverse and RPE fit C-scans showed an irregularity of RPE resembling a 'honeycomb' pattern in 11 (85%) eyes at the point corresponding to the fluorescein leakage site. These were observed as pigment epithelium detachment (PED) on Raster line scan. Six of these 11 eyes (54.5%) showed a disruption/breach in the RPE on transverse C-scan and on RPE fit C-scan. All eyes showed a resolution of subretinal fluid with a closure of microrip, and the honeycombed pattern at the leakage site was replaced with RPE hypertrophy.


CONCLUSIONS
RPE microrips show spontaneous closure in the natural course of CSC.
Gupta
V
V
Advanced Eye Centre, Department of Ophthalmology, Post Graduate Institute of Medical Education and Research, Chandigarh, (UT), India. eyepgi@sify.com
Gupta
P
P
Dogra
M R
MR
Gupta
A
A
D000328:Adult; D056833:Central Serous Chorioretinopathy / Q000150:complications / Q000473:pathology*; D005260:Female; D005654:Fundus Oculi; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012075:Remission, Spontaneous; D012163:Retinal Detachment / Q000209:etiology / Q000473:pathology*; D055213:Retinal Pigment Epithelium / Q000473:pathology*; D041623:Tomography, Optical Coherence / Q000379:methods