title: Concomitant Staphylococcus aureus bacteriuria is associated with complicated S. aureus bacteremia.
abstract: OBJECTIVE
  To identify factors associated with complicated Staphylococcus aureus bacteremia (SAB) in adults.
  
  
  METHODS
  Prospective observational multicenter study during 2 years in Nice University Hospital and during 6 months in the Hôpital Européen Georges Pompidou, Paris, including all adult inpatients with SAB assessed by an Infectious Diseases (ID) specialist.
  
  
  RESULTS
  We included 104 SAB (79 in Nice and 25 in Paris), of which 45 were complicated, including 18 endocarditis and 23 bone and joint infections. A concomitant urine sample was performed in 65% of the cases, showing S. aureus bacteriuria 23/68 (34%) times. Blood cultures were drawn 48-96h after an appropriate antibiotic therapy had been started in 70 of the 104 cases (67%) and were positive in 28 cases (40%).
  
  
  CONCLUSIONS
  The 3 following factors were found to be associated with complicated SAB in univariate analysis: community acquisition (56% vs 26%, P=0.002), concomitant bacteriuria (47% vs 19%, P=0.016) and persistent bacteremia (55% vs 26%, P=0.016). This last factor was associated with endocarditis, but not with other complications such as bone and joint infections.
authors: Centre Hospitalier Universitaire de Nice, Service d'Infectiologie, Hôpital l'Archet 1, BP 3079, 06202 Nice Cedex 3, France. pulcini.c@chu-nice.fr
authors: Céline
authors: C
authors: Pulcini
authors: Matta
authors: M
authors: Matta
authors: Véronique
authors: V
authors: Mondain
authors: Alice
authors: A
authors: Gaudart
authors: Fernand
authors: F
authors: Girard-Pipau
authors: Jean-Luc
authors: JL
authors: Mainardi
authors: Pierre
authors: P
authors: Dellamonica
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016470:Bacteremia / Q000150:complications* / Q000175:diagnosis*; D001437:Bacteriuria / Q000209:etiology*; D015897:Comorbidity / Q000639:trends; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013203:Staphylococcal Infections / Q000150:complications* / Q000175:diagnosis*; D013211:Staphylococcus aureus / Q000302:isolation & purification*; D055815:Young Adult