title: No association of the Val66Met polymorphism of the brain-derived neurotrophic factor with hippocampal volume in major depression.
abstract: Recently, an association of the Val66Met polymorphism of the brain-derived neurotrophic factor with hippocampal volume in patients with major depression has been reported. Here, we aimed at replicating this finding in an independent German sample. We included 79 patients with unipolar major depressive episodes and 84 healthy comparison participants. The brain-derived neurotrophic factor Val66Met polymorphism was determined in all participants. The volume of the hippocampus was manually traced on high-resolution magnetic resonance images. The hippocampal volumes of patients were significantly smaller than those of the comparison participants, confirming previous reports. There was, however, no Val66Met effect on hippocampal volume in either group. To conclude, we did not replicate the Val66Met effect on hippocampal volume in neither patients with major depression nor in healthy participants.
authors: Departments of aPsychiatry bRadiology, University of Bonn, Germany. Jessen@uni-bonn.de
authors: Frank
authors: F
authors: Jessen
authors: Anna
authors: A
authors: Schuhmacher
authors: Ole
authors: O
authors: von Widdern
authors: Vera
authors: V
authors: Guttenthaler
authors: Susanne
authors: S
authors: Hofels
authors: Husam
authors: H
authors: Suliman
authors: Lukas
authors: L
authors: Scheef
authors: Wolfgang
authors: W
authors: Block
authors: Horst
authors: H
authors: Urbach
authors: Wolfgang
authors: W
authors: Maier
authors: Astrid
authors: A
authors: Zobel
mesh_terms: D000328:Adult; D000368:Aged; D019943:Amino Acid Substitution / Q000235:genetics*; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D016022:Case-Control Studies; D003865:Major Depressive Disorder / Q000235:genetics* / Q000473:pathology*; D005260:Female; D020022:Genetic Predisposition to Disease; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D008297:Male; D008715:Methionine / Q000235:genetics; D008875:Middle Aged; D009929:Organ Size; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D014633:Valine / Q000235:genetics; D055815:Young Adult
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D008715:Methionine; D014633:Valine