title: New nonlinear multivariable model shows the relationship between central corneal thickness and HRTII topographic parameters in glaucoma patients.
abstract: OBJECTIVE
  In this paper a new nonlinear multivariable regression method is presented in order to investigate the relationship between the central corneal thickness (CCT) and the Heidelberg Retina Tomograph (HRTII) optic nerve head (ONH) topographic measurements, in patients with established glaucoma.
  
  
  METHODS
  Forty nine eyes of 49 patients with glaucoma were included in this study. Inclusion criteria were patients with (a) HRT II ONH imaging of good quality (SD < 30 mum), (b) reliable Humphrey visual field tests (30-2 program), and (c) bilateral CCT measurements with ultrasonic contact pachymetry. Patients were classified as glaucomatous based on visual field and/or ONH damage. The relationship between CCT and topographic parameters was analyzed by using the new nonlinear multivariable regression model.
  
  
  RESULTS
  In the entire group, CCT was 549.78 +/- 33.08 mum (range: 484-636 mum); intraocular pressure (IOP) was 16.4 +/- 2.67 mmHg (range: 11-23 mmHg); MD was -3.80 +/- 4.97 dB (range: 4.04 - [-20.4] dB); refraction was -0.78 +/- 2.46 D (range: -6.0 D to +3.0 D). The new nonlinear multivariable regression model we used indicated that CCT was significantly related (R(2) = 0.227, p < 0.01) with rim volume nasally and type of diagnosis.
  
  
  CONCLUSIONS
  By using the new nonlinear multivariable regression model, in patients with established glaucoma, our data showed that there is a statistically significant correlation between CCT and HRTII ONH structural measurements, in glaucoma patients.
authors: Department of Ophthalmology, Medical School, 417 Hellenic Army Shared Fund Hospital,Athens University, Athens, Greece. d_kourkoutas@hotmail.com
authors: Dimitrios
authors: D
authors: Kourkoutas
authors: Gerasimos
authors: G
authors: Georgopoulos
authors: Antonios
authors: A
authors: Maragos
authors: Ioannis
authors: I
authors: Apostolakis
authors: George
authors: G
authors: Tsekouras
authors: Irene S
authors: IS
authors: Karanasiou
authors: Dimitrios
authors: D
authors: Papaconstantinou
authors: Evaggelos
authors: E
authors: Iliakis
authors: Michael
authors: M
authors: Moschos