Endothelial cells promote the proliferation of lymphocytes partly through the Wnt pathway via LEF-1.
The function of T cells and B cells is to recognize specific "non-self" antigens, during a process known as antigen presentation. Once they have identified an invader, the cells generate specific responses that are tailored to maximally eliminate specific pathogens or pathogen-infected cells. Endothelial cells (ECs) can trigger the activation of T cells through their class I and class II MHC molecules. In this study, we examined the effect of ECs on the proliferation of lymphocytes. We report that the proliferation of T and B cells can be improved by interaction with ECs. LEF-1 is one of the main molecular mediators in this process, and the inhibition of LEF-1 induces apoptosis. These results suggest that LEF-1 modulates positively the proliferation of lymphocytes induced by their interaction with ECs.
Wang
Shu-Hong
SH
Department of Medical Oncology, The First Affiliated Hospital of The School of Medicine of Xi'an Jiaotong University, Shaanxi Province, PR China.
Nan
Ke-Jun
KJ
Wang
Yao-Chun
YC
D000818:Animals; D017209:Apoptosis; D049109:Cell Proliferation; D015536:Down-Regulation; D004730:Endothelium, Vascular / Q000166:cytology / Q000276:immunology*; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*; D051821:Lymphoid Enhancer-Binding Factor 1 / Q000378:metabolism*; D051379:Mice; D051153:Wnt Proteins / Q000378:metabolism*
C497574:Lef1 protein, mouse; D051821:Lymphoid Enhancer-Binding Factor 1; D051153:Wnt Proteins