title: Successful salvage unrelated umbilical cord blood transplantation with two units after engraftment failure with single unit in severe aplastic anemia.
abstract: Severe aplastic anemia (SAA) patients without an HLA-matched sibling donor need alternative treatment options. Umbilical cord blood transplantation (UCBT) has become an alternative means for treating various diseases, but it has not been proved to be a satisfactory method to treat SAA. Here, we report the case of a girl who underwent successful two-unit UCBT after engraftment failure with a single unit. Two-unit UCBT is proposed to have better engraftment potential and to offer a better chance of survival, according to some reports. Increased cell dose and graft-versus-graft reaction could contribute to these advantages. With this promising result, two-unit UCBT could be an alternative treatment option for patients with SAA without an HLA-matched donor.
authors: Division of Hematology/Oncology, Department of Pediatrics, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea.
authors: Ji Won
authors: JW
authors: Lee
authors: Hyoung Jin
authors: HJ
authors: Kang
authors: Eun Kyung
authors: EK
authors: Kim
authors: Hee Young
authors: HY
authors: Shin
authors: Hyo Seop
authors: HS
authors: Ahn
mesh_terms: D000741:Anemia, Aplastic / Q000175:diagnosis / Q000628:therapy*; D002675:Child, Preschool; D036101:Cord Blood Stem Cell Transplantation; D005260:Female; D006086:Graft vs Host Disease / Q000276:immunology; D006680:HLA Antigens / Q000276:immunology; D006648:Histocompatibility; D006801:Humans; D017404:In Situ Hybridization, Fluorescence
chemical_list: D006680:HLA Antigens