HLA-DRB1 alleles are associated with the clinical course of disease and steroid dependence in Mexican patients with ulcerative colitis.
OBJECTIVE
The aim of this study was to study the association between the HLA-DRB1 alleles and the clinical course of ulcerative colitis (UC).


METHODS
Seventy-five Mexican patients with UC were studied. High resolution HLA typing was performed using Polymerase Chain Reaction-Sequence Specific Oligonucleotide PCR-SSO reverse dot blot and Polymerase Chain Reaction-single specific primer PCR-SSP. Molecular typing techniques were applied to define HLA-DRB1 alleles.


RESULTS
Seventy-five patients (36 female patients, 39 male patients) were studied. Significant associations were found between some HLA-DRB1 alleles and the clinical course of disease: initial active and then inactive and the HLA-DRB1*14 allele (P = 0.03; OR = 4.63; 95% CI: 1.08-21.23); and HLA-DRB1*08 allele (P = 0.04; OR = 4.34; 95% CI: 1.9-33.3). On the other hand, the HLA-DRB1*07 (P = 0.001; OR = 9.76 95% CI: 1.55-65.56) was significantly associated with steroid dependence in UC patients.


CONCLUSIONS
This study suggests that HLA-DRB1 alleles were associated with the clinical course of disease and steroid dependence in UC patients.
Yamamoto-Furusho
J K
JK
Department of Gastroenterology, Instituto Nacional de Ciencias Medicas y Nutricion, Mexico City, Mexico. kazuofurusho@hotmail.com
Rodríguez-Bores
L
L
Granados
J
J
D000328:Adult; D000483:Alleles; D003093:Colitis, Ulcerative / Q000188:drug therapy* / Q000235:genetics* / Q000276:immunology; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; D006801:Humans; D008297:Male; D008800:Mexico; D058889:Molecular Typing; D016133:Polymerase Chain Reaction; D013256:Steroids / Q000627:therapeutic use
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; D013256:Steroids