[The state of enzymatic redox system of glutathione in the blood of patients with lymphosarcoma (non-Hodgkin's lymphoma].
Lipid peroxidation (LPO) processes are enhanced and metabolism is disturbed in patients with lymphosarcoma (LS) (non-Hodgkin's lymphoma). The blood enzymatic redox system was analyzed in patients with LS of two types: lymphoblastic LS (LB LS) and prolymphocytic LS (PL LS). The activities of glutathione reductase (GR), glutathione peroxidase (GP), glutathione dehydroascorbate reductase (GDAR), gamma-glutamyl transpeptidase (GGT), and glucose-6-phosphate dehydrogenase (G6PDH) were spectrophotometrically (Humalyzer 2000, DE) determined in the peripheral plasma, white blood cells, lymphocytes, and red blood cells of 32 aged 42-57 years who had LS and 25 healthy individuals. Peripheral blood lymphocytes and leukocytes were obtained by the method developed by A. Böyum. A search for a correlation was made by the Spearman method. The activities of the enzymes and the data of the correlation analysis suggested antioxidant defense system imbalance and metabolic disturbances in patients with LS. Close functional correlations between GR and GP, GR and G6PDH persisted in patients with both types of the disease. Functional relationships between GR and GDAR remained only in patients with PL LS (r = 0.946; p < 0.001). That between GR and GGT was impaired in patients with LS. A correlation between the activity of antioxidant enzymes and the proliferative activity of blood cells was found in patients with LB LS, which may be used as an additional biochemical test in the differential diagnosis of LS.
Gavriliuk
L A
LA
Robu
M V
MV
Vratichian
A I
AI
Lysyĭ
L T
LT
D000328:Adult; D016022:Case-Control Studies; D005954:Glucosephosphate Dehydrogenase / Q000097:blood; D005978:Glutathione / Q000378:metabolism*; D005979:Glutathione Peroxidase / Q000097:blood; D005980:Glutathione Reductase / Q000097:blood; D006801:Humans; D008214:Lymphocytes / Q000201:enzymology; D008228:Lymphoma, Non-Hodgkin / Q000097:blood* / Q000201:enzymology*; D008875:Middle Aged; D010084:Oxidation-Reduction; D010088:Oxidoreductases / Q000097:blood; D005723:gamma-Glutamyltransferase / Q000097:blood
D010088:Oxidoreductases; D005954:Glucosephosphate Dehydrogenase; D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; C020666:glutathione dehydrogenase (ascorbate); D005723:gamma-Glutamyltransferase; D005978:Glutathione