title: Anterior uveitis complicating zoledronic acid infusion.
abstract: Zoledronic acid is the most effective treatment in patients with hypercalcemia secondary to malignancy; occasionally it can be related to ocular inflammation. We report a case of severe unilateral anterior uveitis following administration of intravenous zoledronic acid in a patient with frontal hyperostosis secondary to breast cancer. The patient developed anterior uveitis 24 hours after the administration of intravenous zoledronate. The patient was treated with topical prednisone and cycloplegic eye drops, with complete recovery after one month. This report shows that, on rare occasions, zoledronic acid can be a possible cause of acute anterior uveitis.
authors: San Raffaele Scientific Institute, Ophthalmology, Milano, Italy. colucci.annalisa@hsr.it
authors: Annalisa
authors: A
authors: Colucci
authors: Giulio
authors: G
authors: Modorati
authors: Elisabetta
authors: E
authors: Miserocchi
authors: Federico
authors: F
authors: Di Matteo
authors: Paolo
authors: P
authors: Rama
mesh_terms: D000368:Aged; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D001943:Breast Neoplasms / Q000150:complications*; D004164:Diphosphonates / Q000008:administration & dosage* / Q000009:adverse effects*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000188:drug therapy* / Q000209:etiology*; D007093:Imidazoles / Q000008:administration & dosage* / Q000009:adverse effects*; D007262:Infusions, Intravenous; D009883:Ophthalmic Solutions; D011241:Prednisone / Q000008:administration & dosage; D014606:Uveitis, Anterior / Q000139:chemically induced* / Q000188:drug therapy; D000077211:Zoledronic Acid
chemical_list: D000893:Anti-Inflammatory Agents; D004164:Diphosphonates; D007093:Imidazoles; D009883:Ophthalmic Solutions; D000077211:Zoledronic Acid; D011241:Prednisone