Insulin analogues.
Development of the insulin analogues has made it possible to reproduce much more accurately the physiologic insulin profiles seen in people who do not have diabetes. The rapidacting analogues, such as insulin aspart and insulin lispro, offer improved postprandial glycemic control and reduced risk of hypoglycemia. The long-acting analogues, such as insulin glargine and insulin detemir, mimic the insulin secretory profile of basal insulin. Together, they approximate physiologic insulin secretion.
Marks
Jennifer
J
University of Miami School of Medicine, Miami, FL 33136, USA. jmarks@med.miami.edu
D003920:Diabetes Mellitus / Q000188:drug therapy*; D006801:Humans; D007004:Hypoglycemic Agents / Q000493:pharmacokinetics / Q000627:therapeutic use*; D007328:Insulin / Q000031:analogs & derivatives* / Q000378:metabolism / Q000493:pharmacokinetics / Q000627:therapeutic use; D061267:Insulin Aspart; D000069057:Insulin Detemir; D000069036:Insulin Glargine; D061268:Insulin Lispro; D000078790:Insulin Secretion; D049528:Insulin, Long-Acting
D007004:Hypoglycemic Agents; D007328:Insulin; D061268:Insulin Lispro; D049528:Insulin, Long-Acting; D000069036:Insulin Glargine; D000069057:Insulin Detemir; D061267:Insulin Aspart