title: An asymmetric hetero-claisen approach to 3-alkyl-3-aryloxindoles.
abstract: The reaction of a chiral N-phenylnitrone derived from Garner's aldehyde with alkylarylketenes generates 3-alkyl-3-aryloxindoles directly in excellent yields and with good to excellent levels of enantioselectivity (up to 90% ee).
authors: EaStCHEM, School of Chemistry, University of St Andrews, North Haugh, St Andrews, KY16 9ST, UK.
authors: Nicolas
authors: N
authors: Duguet
authors: Alexandra M Z
authors: AM
authors: Slawin
authors: Andrew D
authors: AD
authors: Smith
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009589:Nitrogen Oxides / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D000475:Alkenes; D007211:Indoles; D009589:Nitrogen Oxides; C015388:nitrones