Transmembrane vs. non-transmembrane hydrophobic helix topography in model and natural membranes.
Experimental studies have begun to define how formation of transmembrane (TM) vs. non-TM hydrophobic helix topographies is controlled. It has been found that topography is very sensitive to sequence and lipid structure. Interestingly, there is a broad agreement between studies using artificial model membranes and natural membranes. These studies provide important insights into membrane protein insertion and function.
London
Erwin
E
Department of Biochemistry and Cell Biology, Stony Brook, NY 11794-5215, USA. Erwin.London@stonybrook.edu
Shahidullah
Khurshida
K
D000818:Animals; D002462:Cell Membrane / Q000737:chemistry*; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D008055:Lipids / Q000737:chemistry; D008567:Membranes, Artificial
D008055:Lipids; D008567:Membranes, Artificial