title: Hypertriglyceridemia: an independent risk factor of chronic kidney disease in Taiwanese adults.
abstract: BACKGROUND
  The prevalence and incidence of chronic kidney disease (CKD) are relatively high in Taiwanese patients than in patients of other countries, particularly in the older age groups. Dyslipidemia in patients with CKD has been recognized as a risk factor for disease progression but the role of triglycerides (TGs) remains controversial. With this regard, we evaluated the effects of hypertriglyceridemia on renal function in Taiwanese adults (aged >or=40 years).
  
  
  METHODS
  From January 2002 to December 2006, we conducted a community-based medical screening program in Chiayi County with 18,422 subjects (aged >or=40 years). The CKD was defined as an estimated glomerular filtration rate of <60 mL min 1.73 m. Age, body mass index, systolic blood pressure, fasting plasma glucose, and serum total cholesterol were considered as potential confounders.
  
  
  RESULTS
  The CKD was prevalent in 24.2% of the middle-aged and elderly population. By using multiple logistic regression models, we determined that old age and elevated levels of body mass index, systolic blood pressure, fasting plasma glucose, and cholesterol were associated with CKD. The adjusted odds ratios of CKD in participants with serum TG >==200 mg/dL was 1.901 (95% confidence interval: 1.07-3.36; P < 0.05) and in participants with serum TG > 500 mg/dL it increased to 2.205 (1.33-3.64, P < 0.05).
  
  
  CONCLUSIONS
  Hypertriglyceridemia is an independent risk factor for CKD in Taiwanese adults. Thus, an effective screening program that identifies people with hypertriglyceridemia is warranted.
authors: Department of Nephrology, Chang Gung Memorial Hospital, Pu-tzu City, Chiayi, Taiwan.
authors: Pei-Hsien
authors: PH
authors: Lee
authors: Hung-Yu
authors: HY
authors: Chang
authors: Chun-Wu
authors: CW
authors: Tung
authors: Yung-Chien
authors: YC
authors: Hsu
authors: Chen-Chou
authors: CC
authors: Lei
authors: Hsun-Hao
authors: HH
authors: Chang
authors: Hsueh-Fang
authors: HF
authors: Yang
authors: Long-Chuan
authors: LC
authors: Lu
authors: Ming-Chung
authors: MC
authors: Jong
authors: Chiu-Yueh
authors: CY
authors: Chen
authors: Kuei-Ying
authors: KY
authors: Fang
authors: Yu-Shiu
authors: YS
authors: Chao
authors: Ya-Hsueh
authors: YH
authors: Shih
authors: Chun-Liang
authors: CL
authors: Lin
mesh_terms: D000368:Aged; D002908:Chronic Disease; D005260:Female; D006801:Humans; D015228:Hypertriglyceridemia / Q000150:complications*; D015994:Incidence; D007674:Kidney Diseases / Q000453:epidemiology* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D013624:Taiwan / Q000453:epidemiology