Preparation and enantioseparation characteristics of three chiral stationary phases based on modified beta-cyclodextrin for liquid chromatography.
In order to study the effect of the nature and the length of the spacer, three mixed 10-undecenoate/phenylcarbamate derivatives of beta-cyclodextrin have been prepared and linked to allylsilica gel by means of a radical reaction. The chiral recognition ability of the resulting materials, when used as liquid chromatography chiral stationary phases (CSPs), was evaluated using heptane and either 2-propanol or chloroform as organic mobile-phase modifiers. A large variety of racemic compounds have been separated successfully on these CSPs (mainly pharmaceuticals and herbicides). Optimization of these separations was discussed in terms of mobile-phase composition and structural patterns of the injected analytes. The efficiencies of the three prepared materials were compared to those of previously described perphenylated-beta-cyclodextrin column and to analogous cellulose derivative-based CSPs.
Si-Ahmed
Kahina
K
Laboratoire d'Analyse Organique Fonctionnelle, Faculté de Chimie, U.S.T.H.B., B.P. 32, El Alia, Bab Ezzouar, 16111, Alger, Algeria.
Tazerouti
Fairouz
F
Badjah-Hadj-Ahmed
Ahmed Y
AY