Direct palladium-catalyzed arylations of aryl bromides with 2/9-substituted pyrimido[5,4-b]indolizines.
C-5 arylated 2/9-substituted pyrimido[5,4-b]indolizines were synthesized via palladium-catalyzed direct arylation. A variety of substituents on both pyrimido[5,4-b]indolizines and aryl/heteroaryl bromides are tolerated, providing rapid access to substituted pyrimido[5,4-b]indolizines in good to excellent yields.
Jiang
Min
M
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, SIBS, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203 PR China.
Li
Ting
T
Meng
Linghua
L
Yang
Chunhao
C
Xie
Yuyuan
Y
Ding
Jian
J
D001965:Bromides / Q000737:chemistry*; D002384:Catalysis; D007212:Indolizines / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010165:Palladium / Q000737:chemistry*
D001965:Bromides; D007212:Indolizines; D010165:Palladium