Delaumonones A and B, new antiplasmodial quassinoids from Laumoniera bruceadelpha.
New quassinoids, delaumonones A (1) and B (2) have been isolated from the bark of Laumoniera bruceadelpha NOOTEBOOM (Simaroubaceae) and the structures were elucidated by 2D NMR analysis and a chemical correlation. Delaumonones showed an antimalarial activity against Plasmodium falciparum.
Oshimi
Shiori
S
Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan.
Takasaki
Aki
A
Hirasawa
Yusuke
Y
Hosoya
Takahiro
T
Awang
Khalijah
K
Hadi
A Hamid A
AH
Ekasari
Wiwied
W
Widyawaruyanti
Aty
A
Morita
Hiroshi
H
D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D018922:HL-60 Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000592:standards; D008958:Models, Molecular; D008968:Molecular Conformation; D021261:Parasitic Sensitivity Tests; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010963:Plasmodium falciparum / Q000187:drug effects*; D036702:Quassins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D012015:Reference Standards; D029641:Simaroubaceae / Q000737:chemistry*; D013237:Stereoisomerism
D000962:Antimalarials; D010936:Plant Extracts; D036702:Quassins; C543288:delaumonone A; C543289:delaumonone B