title: [Concetration of anticardiolipin antybodies in peritonel fluid and in fluid from lymphocytes culture in women with endometriosis].
abstract: OBJECTIVE
  The aim of our work was to study both the concentration of anticardiolipin antibodies (aCL) in peritoneal fluid in women with endometriosis and to examine peritoneal lymphocyte ability to produce anticardiolipin antibodies.
  
  
  METHODS
  Study group included 30 women with endometriosis. The clinical stages of the disease were assessed by the revised American Fertility Society (rAFS) classification. Reference group included fifteen healthy women, with excluded endometriosis and other pathological disorders within the pelvis. The concentration of aCL in the peritoneal fluid and in fluid from lymphocyte culture was measured by enzyme-linked immunosorbent ELISA assay.
  
  
  RESULTS
  Statistical analysis showed significantly increased mean concentration of aCL in peritoneal fluid in women with endometriosis compared to women from the reference group (p<0.0001). The concentration of aCL in fluid from lymphocyte culture was also significantly higher in samples from women with endometriosis than from the reference group (p<0.0001). The highest mean levels of aCL in peritoneal fluid and in fluid from lymphocyte culture were observed in samples from women with stage I of the disease.
  
  
  CONCLUSIONS
  An increased level of anticardiolipin antibodies in peritoneal fluid in women with endometriosis and increased antibodies production by lymphocytes may suggest an impairment of humoral immunity and its intensification in the early stages of the disease.
authors: Katedra i Zakład Immunologii i Serologii, Slaski Uniwersytet Medyczny w Katowicach. jsikora@sum.edu.pll
authors: Justyna
authors: J
authors: Sikora
authors: Aleksandra
authors: A
authors: Mielczarek-Palacz
authors: Zdzisława
authors: Z
authors: Kondera-Anasz
authors: Jerzy
authors: J
authors: Switała
authors: Ewa
authors: E
authors: Jaśniok
mesh_terms: D000328:Adult; D017153:Antibodies, Anticardiolipin / Q000032:analysis / Q000378:metabolism*; D001202:Ascitic Fluid / Q000737:chemistry*; D016022:Case-Control Studies; D004715:Endometriosis / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D018655:Lymphocyte Count; D012016:Reference Values; D012720:Severity of Illness Index; D016387:Women's Health
chemical_list: D017153:Antibodies, Anticardiolipin