title: Base and copper(I) catalyzed Mannich, alkyne hydroamination cascades for the direct synthesis of 2-methylenepyrrolidines.
abstract: An efficient, simple-to-perform, one-pot reaction cascade to 2-methylenepyrrolidines from p-toluenesulfonyl protected imines and propargylated malonates under a combination of base and copper(I) catalysis is reported.
authors: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, PR China.
authors: Hai-Fei
authors: HF
authors: Wang
authors: Ting
authors: T
authors: Yang
authors: Peng-Fei
authors: PF
authors: Xu
authors: Darren J
authors: DJ
authors: Dixon
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D000586:Amination; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D007097:Imines / Q000737:chemistry; D008314:Malonates / Q000737:chemistry; D008352:Mannich Bases / Q000737:chemistry*; D011759:Pyrrolidines / Q000737:chemistry*
chemical_list: D000480:Alkynes; D007097:Imines; D008314:Malonates; D008352:Mannich Bases; D011759:Pyrrolidines; D003300:Copper