title: In vitro inhibitory effects of palmatine from Enantia chlorantha on Trypanosoma cruzi and Leishmania infantum.
abstract: In an attempt to establish the components responsible for the use of Enantia chlorantha against cutaneous leishmaniasis in local traditional medicine, a well-known palmatine has been isolated in substantial amounts from a methanolic bark extract of this plant species. Palmatine therein obtained exhibited a significant inhibitory activity on growth of both Trypanosoma cruzi (IC(50) 0.068 microM) and Leishmania infantum (IC(50) 0.79 microM).
authors: Faculty of Science, Laboratory of Bio-Organic and Medicinal Chemistry, Department of Organic Chemistry, University of Yaounde I, Yaounde, Cameroon.
authors: Ernestine Tchouboun
authors: ET
authors: Nkwengoua
authors: Igor
authors: I
authors: Ngantchou
authors: Barthélemy
authors: B
authors: Nyasse
authors: Colette
authors: C
authors: Denier
authors: Casimir
authors: C
authors: Blonski
authors: Bernd
authors: B
authors: Schneider
mesh_terms: D000818:Animals; D029061:Annonaceae / Q000737:chemistry*; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001600:Berberine Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018314:Leishmania infantum / Q000187:drug effects*; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014344:Trypanocidal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014349:Trypanosoma cruzi / Q000187:drug effects*
chemical_list: D000981:Antiprotozoal Agents; D001600:Berberine Alkaloids; D010936:Plant Extracts; D014344:Trypanocidal Agents; C005413:palmatine