Effect of melatonin on myocardial oxidative stress induced by experimental obstructive jaundice.
OBJECTIVE
melatonin has been demonstrated to have active antioxidant properties in different tissues during experimental cholestasis. The aim of this research was to study myocardial oxidative stress on obstructive jaundice, and to analyze the effect of melatonin on myocardial oxidative lesions.


METHODS
we achieved cholestasis by ligature and sectioning of the main bile duct. Melatonin was administered intraperitoneally (500 microg/kg/day). We measured malondialdehyde (MDA), reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD) and glutathione peroxydase (GPx) antioxidant enzyme levels in the heart tissue.


RESULTS
obstructive cholestasis increased MDA and decreased GSH as well as all antioxidant enzymes. Melatonin administration significantly decreased MDA values, and increased GSH and antioxidant enzymes on the icteric animal myocardium.


CONCLUSIONS
melatonin treatment prevents oxidative stress in the cardiac tissue as induced by experimental cholestasis.
Cruz
A
A
Department of General Surgery, Reina Sofía University Hospital, Córdoba, Spain.
Tasset
I
I
Ramírez
L M
LM
Arjona
A
A
Segura
J
J
Túnez
I
I
Montilla
P
P
Muntané
J
J
Padillo
F J
FJ
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D041781:Jaundice, Obstructive / Q000378:metabolism*; D008550:Melatonin / Q000502:physiology*; D009206:Myocardium / Q000378:metabolism*; D018384:Oxidative Stress; D051381:Rats; D017208:Rats, Wistar
D000975:Antioxidants; D008550:Melatonin