title: Molecular targeting of cancer stem cells.
abstract: Cancer stem cells may be important targets for new anticancer drugs. In two recent articles in Cell Stem Cell, Jin et al. (2009) and Hoey et al. (2009) provide proof of principle for this idea in experimental models of solid tumors and leukemias, respectively.
authors: MRC Molecular Haematology Unit, The Weatherall Institue of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK.
authors: Rajeev
authors: R
authors: Gupta
authors: Paresh
authors: P
authors: Vyas
authors: Tariq
authors: T
authors: Enver
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D006801:Humans; D053650:Interleukin-3 Receptor alpha Subunit / Q000037:antagonists & inhibitors*; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins / Q000037:antagonists & inhibitors*; D051379:Mice; D009369:Neoplasms / Q000188:drug therapy / Q000628:therapy*; D014411:Neoplastic Stem Cells / Q000187:drug effects*; D051880:Receptors, Notch / Q000037:antagonists & inhibitors
chemical_list: D000911:Antibodies, Monoclonal; D000970:Antineoplastic Agents; D053650:Interleukin-3 Receptor alpha Subunit; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D051880:Receptors, Notch; C064045:delta protein