title: Regulation of thrombin activity with a bifunctional aptamer and hemin: development of a new anticoagulant and antidote pair.
authors: Department of Biochemistry and National Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, China.
authors: Jing
authors: J
authors: Wang
authors: Ya
authors: Y
authors: Cao
authors: Guifang
authors: G
authors: Chen
authors: Genxi
authors: G
authors: Li
mesh_terms: D000925:Anticoagulants / Q000737:chemistry* / Q000378:metabolism; D000931:Antidotes / Q000737:chemistry* / Q000378:metabolism; D052157:Aptamers, Nucleotide / Q000737:chemistry* / Q000378:metabolism; D002942:Circular Dichroism; D006427:Hemin / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D013056:Spectrophotometry, Ultraviolet; D013917:Thrombin / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013918:Thrombin Time
chemical_list: D000925:Anticoagulants; D000931:Antidotes; D052157:Aptamers, Nucleotide; C081676:thrombin aptamer; D006427:Hemin; D013917:Thrombin