Medication overdoses leading to emergency department visits among children.
BACKGROUND
The high prevalence of medication use increases the potential for medication overdoses, especially among children.


OBJECTIVE
This paper describes the burden of unintentional pediatric medication overdoses in order to target new prevention efforts.


METHODS
Data were analyzed in 2007 and 2008 from the National Electronic Injury Surveillance System, collected January 1, 2004, through December 31, 2005, to estimate the number of emergency department visits resulting from unintentional medication overdoses among children aged <or=18 years in the U.S. These data were analyzed by patient demographics, overdose cause, and implicated products, and compared to visits for nonpharmaceutical consumer product poisonings.


RESULTS
Based on 3034 cases, an estimated 71,224 emergency department visits for medication overdoses were made annually by children aged <or=18 years, representing 68.9% of emergency department visits for unintentional pediatric poisonings. The rate of unintentional poisonings from medications was twice the rate of those from nonpharmaceutical consumer products (9.2 visits per 10,000 individuals per year [95% CI=7.3, 11.0] vs 4.2 per 10,000 individuals per year [95% CI=3.3, 5.0]). Four fifths (82.2%) of visits for medication overdoses were from unsupervised ingestions (children accessing medications on their own); medication errors and misuse resulted in 14.3% of visits. Most visits (81.3%) involved children aged <or=5 years, and commonly available over-the-counter medications were implicated in one third (33.9%) of visits.


CONCLUSIONS
Medication overdoses among children, notably unsupervised ingestions, represent a substantial burden in terms of emergency department visits and hospitalizations. New efforts to prevent pediatric medication overdoses are needed.
Schillie
Sarah F
SF
Epidemic Intelligence Service, Office of Workforce and Career Development, CDC, Atlanta, Georgia 30333, USA.
Shehab
Nadine
N
Thomas
Karen E
KE
Budnitz
Daniel S
DS
D000293:Adolescent; D016907:Adverse Drug Reaction Reporting Systems; D002648:Child; D002675:Child, Preschool; D062787:Drug Overdose / Q000453:epidemiology*; D064420:Drug-Related Side Effects and Adverse Reactions / Q000453:epidemiology*; D004636:Emergency Service, Hospital / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D011159:Population Surveillance; D015995:Prevalence; D014481:United States / Q000453:epidemiology