CD95/Fas in the brain--not just a killer.
Although CD95 (Fas/Apo-1) has long been known to be broadly expressed in the brain, its function has remained enigmatic. In this issue of Cell Stem Cell, Corsini et al. (2009) now show that CD95 serves as a potent activator of neurogenesis in both the healthy and injured brain.
Beier
Christoph P
CP
Department of Neurology, University Hospital RWTH Aachen, Aachen, Germany.
Schulz
Jörg B
JB
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D001921:Brain / Q000378:metabolism*; D038362:Glycogen Synthase Kinase 3 / Q000378:metabolism; D000071679:Glycogen Synthase Kinase 3 beta; D006801:Humans; D055495:Neurogenesis; D011494:Protein Kinases / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology; D013234:Stem Cells / Q000378:metabolism*; D058570:TOR Serine-Threonine Kinases; D019014:fas Receptor / Q000378:metabolism*
D019014:fas Receptor; D011494:Protein Kinases; C546842:MTOR protein, human; D000071679:Glycogen Synthase Kinase 3 beta; D058570:TOR Serine-Threonine Kinases; D038362:Glycogen Synthase Kinase 3