Acromegaly associated with multiple tumors.
A 56-year-old man was admitted to our hospital for the surgical removal of renal cell carcinoma (RCC). He was diagnosed with acromegaly due to his characteristic clinical features, endocrine data, and the presence of pituitary tumor. He was found to have colon cancer and follicular thyroid tumor. Pathological examination of the pituitary tumor after transsphenoidal surgery was compatible with growth hormone (GH)-secreting pituitary adenoma. We also detected the transcripts and/or immunoreactivity of GH/insulin-like growth factor I components in the tumor specimen. This is a rare case of acromegaly associated with multiple tumors, including RCC, colon cancer and thyroid tumor.
Sekizawa
Naoko
N
Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School, Tokyo.
Hayakawa
Eri
E
Tsuchiya
Kyoichiro
K
Yoshimoto
Takanobu
T
Akashi
Takumi
T
Fujii
Takeshi
T
Yamada
Shozo
S
Hirata
Yukio
Y
D000172:Acromegaly / Q000209:etiology*; D001483:Base Sequence; D002292:Carcinoma, Renal Cell / Q000150:complications / Q000235:genetics / Q000378:metabolism; D003110:Colonic Neoplasms / Q000150:complications / Q000235:genetics / Q000378:metabolism; D017931:DNA Primers / Q000235:genetics; D015870:Gene Expression; D006801:Humans; D007150:Immunohistochemistry; D007334:Insulin-Like Growth Factor I / Q000235:genetics / Q000378:metabolism; D007680:Kidney Neoplasms / Q000150:complications / Q000235:genetics / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000150:complications* / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism; D010911:Pituitary Neoplasms / Q000150:complications / Q000235:genetics / Q000378:metabolism; D017526:Receptor, IGF Type 1 / Q000235:genetics / Q000378:metabolism; D011986:Receptors, Somatotropin / Q000235:genetics / Q000378:metabolism; D013964:Thyroid Neoplasms / Q000150:complications / Q000235:genetics / Q000378:metabolism
D017931:DNA Primers; D011986:Receptors, Somatotropin; D007334:Insulin-Like Growth Factor I; D017526:Receptor, IGF Type 1