title: Depression and symptoms affect quality of life in psychogenic nonepileptic seizures.
abstract: BACKGROUND
  In patients with active epilepsy, adverse medication effects and severity of depression are correlated with health-related quality of life, but seizure frequency is not. We sought to examine if the same pattern exists in patients with psychogenic nonepileptic seizures (PNES).
  
  
  METHODS
  We administered seizure calendars, quality of life (QOL) scales, depression scales, and symptom checklists to 49 patients with video EEG-confirmed PNES. Data analysis consisted of performing Pearson correlation coefficients, scatter plots, and t tests.
  
  
  RESULTS
  Depression and symptom scores significantly increased as health-related QOL scores decreased (partial correlation coefficient r = -0.73 for both comparisons), whereas seizure count was nonsignificant (partial correlation coefficient r = -0.19).
  
  
  CONCLUSIONS
  As is seen in epilepsy, patients with psychogenic nonepileptic seizures demonstrate that higher depressive symptoms and somatic symptoms are independently related to worsening quality of life (QOL); however, seizure frequency is not. Seizure frequency is an important focus in patient care and treatment trials. The findings underscore the importance of, along with seizure counts, also examining QOL, depression, and somatic symptoms in patients with seizures.
authors: Departments of Neurology and Psychiatry (W.C.L.), Rhode Island Hospital, Brown Medical School, Providence, RI, USA. William_LaFrance_Jr@Brown.edu
authors: W Curt
authors: WC
authors: LaFrance
authors: Stephanie
authors: S
authors: Syc
mesh_terms: D000328:Adult; D003866:Depressive Disorder / Q000209:etiology* / Q000523:psychology*; D004185:Disability Evaluation; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011788:Quality of Life / Q000523:psychology*; D012640:Seizures / Q000150:complications* / Q000523:psychology*; D012720:Severity of Illness Index; D013001:Somatoform Disorders / Q000150:complications / Q000523:psychology; D014741:Video Recording; D055815:Young Adult