The Systems Biology Graphical Notation.
Circuit diagrams and Unified Modeling Language diagrams are just two examples of standard visual languages that help accelerate work by promoting regularity, removing ambiguity and enabling software tool support for communication of complex information. Ironically, despite having one of the highest ratios of graphical to textual information, biology still lacks standard graphical notations. The recent deluge of biological knowledge makes addressing this deficit a pressing concern. Toward this goal, we present the Systems Biology Graphical Notation (SBGN), a visual language developed by a community of biochemists, modelers and computer scientists. SBGN consists of three complementary languages: process diagram, entity relationship diagram and activity flow diagram. Together they enable scientists to represent networks of biochemical interactions in a standard, unambiguous way. We believe that SBGN will foster efficient and accurate representation, visualization, storage, exchange and reuse of information on all kinds of biological knowledge, from gene regulation, to metabolism, to cellular signaling.
Le Novère
Nicolas
N
EMBL European Bioinformatics Institute, Hinxton, UK. lenov@ebi.ac.uk
Hucka
Michael
M
Mi
Huaiyu
H
Moodie
Stuart
S
Schreiber
Falk
F
Sorokin
Anatoly
A
Demir
Emek
E
Wegner
Katja
K
Aladjem
Mirit I
MI
Wimalaratne
Sarala M
SM
Bergman
Frank T
FT
Gauges
Ralph
R
Ghazal
Peter
P
Kawaji
Hideya
H
Li
Lu
L
Matsuoka
Yukiko
Y
Villéger
Alice
A
Boyd
Sarah E
SE
Calzone
Laurence
L
Courtot
Melanie
M
Dogrusoz
Ugur
U
Freeman
Tom C
TC
Funahashi
Akira
A
Ghosh
Samik
S
Jouraku
Akiya
A
Kim
Sohyoung
S
Kolpakov
Fedor
F
Luna
Augustin
A
Sahle
Sven
S
Schmidt
Esther
E
Watterson
Steven
S
Wu
Guanming
G
Goryanin
Igor
I
Kell
Douglas B
DB
Sander
Chris
C
Sauro
Herbert
H
Snoep
Jacky L
JL
Kohn
Kurt
K
Kitano
Hiroaki
H
D003196:Computer Graphics / Q000266:history; D049673:History, 20th Century; D020407:Internet; D012984:Software; D049490:Systems Biology / Q000266:history