[BRCA 1 and BRCA 2 gens in breast cancer].
The development of molecular genetics last years brought a better understanding of the mechanisms of breast cancer development. "The hereditary" breast cancer is very much connected with the BRCA 1 and BRCA 2 gene mutations. Recent studies suggest a role for BRCA 1 and BRCA 2 in transcriptional regulation, as it possesses a conserved NH2 terminal ring finger domain and an COOH domain. This role would be consistent with the reported localization of the BRCA 1/BRCA 2 protein to the nucleus. The BRCA 1 and BRCA 2 may play an as yet undefined protective role in cells, as it is expressed in epithelial cells undergoing high levels of proliferation in association with differentiation.
Habibović
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Von Rotem Kreuz Krankenhaus Maingau Frankfurt am Main, Germany.
Hrgović
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D001943:Breast Neoplasms / Q000235:genetics*; D005260:Female; D019398:Genes, BRCA1 / Q000502:physiology; D024522:Genes, BRCA2 / Q000502:physiology; D020022:Genetic Predisposition to Disease; D006801:Humans