title: Dietary glycemic load, glycemic index, and refined grains intake are associated with reduced beta-cell function in prediabetic Japanese migrants.
abstract: OBJECTIVE
  To investigate the association between carbohydrate intakes and beta-cell function (HOMA-beta) in Japanese-Brazilians with impaired glucose tolerance (IGT).
  
  
  METHODS
  Dietary intakes were assessed by a validated food frequency questionnaire in a cross-sectional survey carried out in 2000. The associations between diet and HOMA-beta were verified in 270 newly diagnosed IGT in multiple linear regression models.
  
  
  RESULTS
  The mean (SD) age was 58 (11) years and the mean HOMA-beta was 65 (47). The glycemic load was inversely associated with HOMA-beta, beta1 -0.140 (95%CI = -1.044; -0.078), p = 0.023. The inverse association was also observed for refined grains intakes: -0.186 (95%CI = -0.4862; -0.058), p = 0.012. After adjustments for body mass index, the glycemic index was inversely associated with HOMA-beta: -0.1246 (95%CI = -2.2482, -0.0257), p < 0.001.
  
  
  CONCLUSIONS
  These data suggested that dietary glycemic load, glycemic index, and refined grains intakes are associated with reduced beta-cell function, and the quality of dietary carbohydrates may be relevant for maintaining beta-cell function among individuals with IGT.
authors: Departamento de Medicina Social, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil. daniss@fmrp.usp.br
authors: Daniela Saes
authors: DS
authors: Sartorelli
authors: Laércio Joel
authors: LJ
authors: Franco
authors: Renata
authors: R
authors: Damião
authors: Suely
authors: S
authors: Gimeno
authors: Marly Augusto
authors: MA
authors: Cardoso
authors: Sandra Roberta Gouvea
authors: SR
authors: Ferreira
mesh_terms: D001938:Brazil; D004040:Dietary Carbohydrates / Q000378:metabolism*; D002523:Edible Grain / Q000145:classification / Q000378:metabolism*; D004812:Epidemiologic Methods; D005260:Female; D018149:Glucose Intolerance / Q000378:metabolism; D038321:Glycemic Index / Q000502:physiology*; D006801:Humans; D050417:Insulin-Secreting Cells / Q000378:metabolism*; D007564:Japan / Q000208:ethnology; D008297:Male; D008875:Middle Aged; D011236:Prediabetic State / Q000208:ethnology / Q000378:metabolism; D014171:Transients and Migrants / Q000706:statistics & numerical data
chemical_list: D004040:Dietary Carbohydrates