Startle cue-reactivity differentiates between light and heavy smokers.
OBJECTIVE
It was assumed that the startle amplitude in smokers is reduced while viewing pictures of smoking, suggesting that smoking cues are appetitive. The goal of the present study was to investigate (i) whether smoking scenes induce appetitive cue effects in smokers, and (ii) whether smoking intensity is related to cue-reactivity.


METHODS
Smokers and non-smokers participated in a single session.


METHODS
A total of 62 individuals participated: 36 smokers and 26 non-smokers.


METHODS
Participants took part in an acoustic affective startle experiment using standardized pleasant, neutral and unpleasant scenes from the International Affective Picture System (IAPS), as well as pictures of smoking. The effect of smoking cues was assessed by comparing neutral and smoking scenes (termed cue-related startle suppression, CSS).


RESULTS
While there was no overall difference between smokers and non-smokers regarding the CSS, light smokers showed significantly increased cue-reactivity towards smoking-related cues, as compared with heavy smokers and non-smokers. In addition, light smokers also displayed stronger appetitive responses towards positive stimuli.


CONCLUSIONS
These data support recent theories which discriminate between habit-based and incentive-based drug abuse. This distinction may have consequences for the assessment and treatment of drug-addicted subjects. Furthermore, incentive-based light smoking seems to have general effects on the reward system.
Rehme
Anne K
AK
Department of Psychiatry, University of Bonn, Bonn, Germany. arehme@nf.mpg.de
Frommann
Ingo
I
Peters
Sandra
S
Block
Verena
V
Bludau
Julia
J
Quednow
Boris B
BB
Maier
Wolfgang
W
Schütz
Christian
C
Wagner
Michael
M
D000161:Acoustic Stimulation; D000339:Affect; D000704:Analysis of Variance; D001070:Appetitive Behavior; D016739:Behavior, Addictive / Q000503:physiopathology* / Q000523:psychology; D016022:Case-Control Studies; D003463:Cues; D004576:Electromyography; D005260:Female; D006801:Humans; D008297:Male; D010775:Photic Stimulation; D013216:Reflex, Startle / Q000502:physiology*; D012720:Severity of Illness Index; D012907:Smoking / Q000503:physiopathology* / Q000523:psychology; D013997:Time Factors