Molecular targeting of cancer stem cells.
Cancer stem cells may be important targets for new anticancer drugs. In two recent articles in Cell Stem Cell, Jin et al. (2009) and Hoey et al. (2009) provide proof of principle for this idea in experimental models of solid tumors and leukemias, respectively.
Gupta
Rajeev
R
MRC Molecular Haematology Unit, The Weatherall Institue of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK.
Vyas
Paresh
P
Enver
Tariq
T
D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D006801:Humans; D053650:Interleukin-3 Receptor alpha Subunit / Q000037:antagonists & inhibitors*; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins / Q000037:antagonists & inhibitors*; D051379:Mice; D009369:Neoplasms / Q000188:drug therapy / Q000628:therapy*; D014411:Neoplastic Stem Cells / Q000187:drug effects*; D051880:Receptors, Notch / Q000037:antagonists & inhibitors
D000911:Antibodies, Monoclonal; D000970:Antineoplastic Agents; D053650:Interleukin-3 Receptor alpha Subunit; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D051880:Receptors, Notch; C064045:delta protein