Urinary levels of glycosaminoglycans in patients with idiopathic detrusor overactivity.
OBJECTIVE
We assessed whether urinary excretion of glycosaminoglycans (GAGs) may be affected by a condition of detrusor overactivity (DO).


METHODS
We evaluated 24-h urinary excretion of GAGs in 25 patients (mean age 63.81 years) with DO and in 14 healthy controls (mean age 65.75 years). No patients or controls had urinary tract infection. The excretion of GAGs was measured on the basis of total urine volume and normalized to creatinine concentration. Student's test was employed to check between the urinary excretion of GAGs in the two groups.


RESULTS
The urinary content of GAGs discovered in control group was significantly higher than that in pathological group for the ratio GAGs/creatinine concentration.


CONCLUSIONS
The low content of GAGs might be due to relative ischemia of the bladder wall epithelial layer following a chronically increased contractile activity of the detrusor even if further studies are needed to confirm this finding.
Siracusano
Salvatore
S
Department of Urology, Trieste University, Cattinara Hospital, Via Strada di Fiume 447, 34100, Trieste, Italy. siracus@units.it
Cucchi
Antonio
A
Ciciliato
Stefano
S
Lampropoulou
Nicolitza
N
Vittur
Franco
F
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D006025:Glycosaminoglycans / Q000652:urine*; D006801:Humans; D008297:Male; D008875:Middle Aged; D053201:Urinary Bladder, Overactive / Q000652:urine*; D055815:Young Adult
D006025:Glycosaminoglycans; C020341:glucosaminoglycans