Dental development in children with growth hormone insensitivity syndrome: Demirjian analysis of serial panoramic radiographs.
OBJECTIVE
This study evaluates the effects of 8 years of insulinlike growth factor-I therapy on tooth development in patients with growth hormone insensitivity syndrome.


METHODS
Forty-nine panoramic radiographs were evaluated from eight patients (six boys, two girls). Seven teeth in the mandibular left region were graded according to the Demirjian system. Radiographs were taken at the start of insulinlike growth factor-I therapy and were continued at approximately yearly intervals for 8 years.


RESULTS
Three of six boys and one of two girls who began treatment with insulinlike growth factor-I at earlier ages experienced an increase in the rate of tooth development. One of six boys who began treatment with insulinlike growth factor-I at a later age had a slower rate of dental development. The patients had more rapid tooth maturation during the beginning of treatment. By the end of treatment, all patients had normal dental maturity for their age.


CONCLUSIONS
Treatment of growth hormone insensitivity syndrome with insulinlike growth factor-I appears to lead to an increase in dental maturation, particularly in younger patients. After 8 years all patients had achieved normal dental development.
Campbell
Richard
R
Division of Pediatric Dentistry, Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA. Richard.campbell@cchmc.org
Weinshel
Randy
R
Backeljauw
Philippe
P
Wilson
Stephen
S
Bean
Judy
J
Shao
Mingyuan
M
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D019229:Dentition, Permanent; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007334:Insulin-Like Growth Factor I / Q000627:therapeutic use; D046150:Laron Syndrome / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000473:pathology; D008297:Male; D008445:Maxillofacial Development; D011862:Radiography, Panoramic; D014094:Tooth, Deciduous
D007334:Insulin-Like Growth Factor I