Electrospinning of polysaccharides for regenerative medicine.
Electrospinning techniques enable the production of continuous fibers with dimensions on the scale of nanometers from a wide range of natural and synthetic polymers. The number of recent studies regarding electrospun polysaccharides and their derivatives, which are potentially useful for regenerative medicine, is increasing dramatically. However, difficulties regarding the processibility of the polysaccharides (e.g., poor solubility and high surface tension) have limited their application. In this review, we summarize the characteristics of various polysaccharides such as alginate, cellulose, chitin, chitosan, hyaluronic acid, starch, dextran, and heparin, which are either currently being used or have potential to be used for electrospinning. The recent progress of nanofiber matrices electrospun from polysaccharides and their biomedical applications in tissue engineering, wound dressings, drug delivery, and enzyme immobilization are discussed.
Lee
Kuen Yong
KY
Department of Bioengineering, Hanyang University, Seoul, South Korea.
Jeong
Lim
L
Kang
Yun Ok
YO
Lee
Seung Jin
SJ
Park
Won Ho
WH
D004563:Electrochemistry; D008855:Microscopy, Electron, Scanning; D015394:Molecular Structure; D057139:Nanofibers / Q000737:chemistry* / Q000648:ultrastructure; D011134:Polysaccharides / Q000737:chemistry* / Q000648:ultrastructure; D044968:Regenerative Medicine; D054457:Tissue Scaffolds / Q000737:chemistry*
D011134:Polysaccharides