title: Direct palladium-catalyzed arylations of aryl bromides with 2/9-substituted pyrimido[5,4-b]indolizines.
abstract: C-5 arylated 2/9-substituted pyrimido[5,4-b]indolizines were synthesized via palladium-catalyzed direct arylation. A variety of substituents on both pyrimido[5,4-b]indolizines and aryl/heteroaryl bromides are tolerated, providing rapid access to substituted pyrimido[5,4-b]indolizines in good to excellent yields.
authors: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, SIBS, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203 PR China.
authors: Min
authors: M
authors: Jiang
authors: Ting
authors: T
authors: Li
authors: Linghua
authors: L
authors: Meng
authors: Chunhao
authors: C
authors: Yang
authors: Yuyuan
authors: Y
authors: Xie
authors: Jian
authors: J
authors: Ding
mesh_terms: D001965:Bromides / Q000737:chemistry*; D002384:Catalysis; D007212:Indolizines / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010165:Palladium / Q000737:chemistry*
chemical_list: D001965:Bromides; D007212:Indolizines; D010165:Palladium