title: Gold-catalyzed cascade Friedel-Crafts/furan-alkyne cycloisomerizations for the highly efficient synthesis of arylated (Z)-enones or -enals.
abstract: An efficient domino approach for the synthesis of arylated (Z)-enones or -enals through gold(I)-catalyzed reactions of enynols with furans was developed. PPh(3)AuNTf(2) was found to be an excellent catalyst to catalyze both of the Friedel-Crafts and furan/alkyne cyclization reactions in the same vessel. This method offers several advantages such as high stereoselectivities, mild reaction conditions, and easily accessible starting materials.
authors: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, People's Republic of China.
authors: Yifeng
authors: Y
authors: Chen
authors: Yuhua
authors: Y
authors: Lu
authors: Guijie
authors: G
authors: Li
authors: Yuanhong
authors: Y
authors: Liu