The CB1 receptor agonist, WIN 55,212-2, dose-dependently disrupts object recognition memory in adult rats.
Drugs that act as agonists at the cannabinoid CB(1) receptor have been reported to interfere with a diverse range of cognitive functions, including object recognition memory. However, to date, most of the studies conducted on this aspect of memory have suggested that these effects occur mainly in pubertal or pre-pubertal, rather than adult, rats. In this study we revisited this issue and evaluated the effects of a single s.c. injection of the CB(1) receptor agonist, WIN 55,212-2 ('WIN'), at 1, 3 or 5mg/kg, on object recognition memory. We found that WIN significantly reduced the total exploration time for objects at the 5mg/kg dose only (P<0.05). This was presumably due to its sedative effects at this dose. However, the discrimination index, which controlled for the general effects of WIN on object exploration, was significantly reduced only for the 1mg/kg WIN group (P<0.05), suggesting that only at this low dose did WIN specifically interfere with object discrimination. These results suggest that WIN can interfere with object recognition memory even in adult rats following a single injection of a low dose.
Baek
Jean ha
Jh
Dept. of Pharmacology and Toxicology, School of Medical Sciences, University of Otago Medical School, Dunedin, New Zealand.
Zheng
Yiwen
Y
Darlington
Cynthia L
CL
Smith
Paul F
PF
D000818:Animals; D048588:Benzoxazines / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008297:Male; D009025:Morpholines / Q000008:administration & dosage / Q000494:pharmacology*; D009281:Naphthalenes / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D043884:Receptor, Cannabinoid, CB1 / Q000819:agonists*; D021641:Recognition, Psychology / Q000187:drug effects*
D048588:Benzoxazines; D009025:Morpholines; D009281:Naphthalenes; D043884:Receptor, Cannabinoid, CB1; C070417:(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone