Study of analgesic and anti-inflammatory effects of lappaconitine gelata.
OBJECTIVE
To explore the analgesic and anti-inflammatory effects of lappaconitine gelata (LA).


METHODS
The writhing response induced by acetic acid, the pain response induced by formaldehyde and hot plate method in the mouse, and the paw edema induced by egg albumen in the rat and the ear edema induced by xylene in the mouse were used for investigation on the analgesic and anti-inflammatory effects of LA.


RESULTS
The writhing response induced by acetic acid, the pain response induced by formaldehyde and hot plate methods was significantly inhibited by LA. In addition, the paw edema induced by egg albumen in the rat and the ear edema induced by xylene in the mouse were all significantly suppressed by LA.


CONCLUSIONS
LA has the analgesic and anti-inflammatory effects.
Wang
Ying-zi
YZ
College of Chinese Materia Medica, Beijing University of Traditional Chinese Medicine, Beijing 100102, China.
Xiao
Yong-qing
YQ
Zhang
Chao
C
Sun
Xiu-mei
XM
D000157:Aconitine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000700:Analgesics / Q000627:therapeutic use*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D051379:Mice; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy; D051381:Rats; D017208:Rats, Wistar
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D004365:Drugs, Chinese Herbal; D000157:Aconitine; C022150:lappaconitine