Recent progress in enzymatic resolution and desymmetrization of pharmaceuticals and their intermediates.
The literature is surveyed from mid-1998 through to August 2000 for examples of the resolution or desymmetrization of existing/potential pharmaceutical entities and pharmaceutical intermediates, and of chiral building blocks for pharmaceutical manufacture. Examples of commercial interest are included with new developments in the art of resolution.
Pesti
J A
JA
DuPont Pharmaceutical Company, Chemical Process Research & Development, DuPont Experimental Station, E336/147 Wilmington, DE 19880-0336, USA. jaan.a.pesti@dupontpharma.com
Dicosimo
R
R