Natural anthraquinone derivatives from a marine mangrove plant-derived endophytic fungus Eurotium rubrum: structural elucidation and DPPH radical scavenging activity.
There is considerable interest in the isolation of potent radical scavenging compounds from natural resources to treat diseases involving oxidative stress. In this report, four new fungal metabolites including one new bisdihydroanthracenone derivative (1, eurorubrin), two new seco-anthraquinone derivatives [3, 2-O-methyl-9-dehydroxyeurotinone and 4, 2-Omethyl- 4-O-(alpha-D-ribofuranosyl)-9-dehydroxyeurotinone], and one new anthraquinone glycoside [6, 3-O-(alpha-D-ribofuranosyl)- questin], were isolated and identified from Eurotium rubrum, an endophytic fungal strain that was isolated from the inner tissue of the stem of the marine mangrove plant Hibiscus tiliaceus. In addition, three known compounds including asperflavin (2), 2-O-methyleurotinone (5), and questin (7) were also isolated and identified. Their structures were elucidated on the basis of spectroscopic analysis. All of the isolated compounds were evaluated for 1,1-diphenyl-2-picrylhydrazyl(DPPH) radical scavenging activity.
Li
Dong-Li
DL
Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, P. R.China.
Li
Xiao-Ming
XM
Wang
Bin-Gui
BG
D000873:Anthracenes / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism; D000875:Anthralin / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism; D000880:Anthraquinones / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism; D001713:Biphenyl Compounds / Q000737:chemistry* / Q000378:metabolism; D002681:China; D004642:Emodin / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism; D055325:Eurotium / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism; D016166:Free Radical Scavengers / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism; D031584:Hibiscus / Q000382:microbiology*; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism; D010851:Picrates / Q000737:chemistry* / Q000378:metabolism
C544954:2-O-methyl-4-O-ribofuranosyl-9-dehydroxyeurotinone; C544953:2-O-methyl-9-dehydroxyeurotinone; C544956:2-O-methyleurotinone; C544955:3-O-ribofuranosylquestin; D000873:Anthracenes; D000880:Anthraquinones; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D006027:Glycosides; D007783:Lactones; D010851:Picrates; C544952:eurorubrin; C048944:questin; C002455:asperflavin; C004931:1,1-diphenyl-2-picrylhydrazyl; D004642:Emodin; D000875:Anthralin