title: Smooth endoplasmic reticulum aggregations in all retrieved oocytes causing recurrent multiple anomalies: case report.
abstract: OBJECTIVE
  To document the relationship between smooth endoplasmic reticulum (SER) aggregations and recurrent fetal anomalies.
  
  
  METHODS
  Case report.
  
  
  METHODS
  Private IVF center.
  
  
  METHODS
  A 28-year-old woman with an 11-year history of primary infertility.
  
  
  METHODS
  Three consecutive cycles of intracytoplasmic sperm injection (ICSI) in the same patient.
  
  
  METHODS
  Clinical pregnancy, live birth, fetal anomaly.
  
  
  RESULTS
  In three consecutive ICSI cycles, a total of 59 MII oocytes were retreived in the same patient, all displaying SER aggregations. The fertilization rate per cycle was 80%, 50%, and 42%, respectively. A total of 12 embryos were transferred in three ICSI cycles, of which 11 were grade 1 embryos. Two of the three cycles ended up with clinical ongoing pregnancies but with multiple fetal anomalies.
  
  
  CONCLUSIONS
  This is the first case reported with SER aggregations in all retrieved oocytes in three consecutive ICSI cycles. The repetetive multiple fetal anomalies possibly related to oocyte dysmorphism are of concern.
authors: Ankara Private IVF Center, Ankara, Turkey.
authors: Cem
authors: C
authors: Akarsu
authors: Ankara Private IVF Center, Ankara, Turkey; Present address: Department of Obstetrics and Gynecology, Ufuk University Faculty of Medicine, Ankara, Turkey. Electronic address: gamzesinem@hotmail.com.
authors: Gamze
authors: G
authors: Çağlar
authors: Ankara Private IVF Center, Ankara, Turkey.
authors: Kubilay
authors: K
authors: Vicdan
authors: Ankara Private IVF Center, Ankara, Turkey.
authors: Eran
authors: E
authors: Sözen
authors: Department of Obstetrics and Gynecology, Gazi University Faculty of Medicine, Ankara, Turkey.
authors: Kutay
authors: K
authors: Biberoğlu
mesh_terms: D000015:Abnormalities, Multiple / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D000328:Adult; D018871:Endoplasmic Reticulum, Smooth / Q000473:pathology*; D005260:Female; D006801:Humans; D007246:Infertility / Q000209:etiology; D008297:Male; D054315:Oocyte Retrieval; D009865:Oocytes / Q000473:pathology* / Q000648:ultrastructure; D011247:Pregnancy; D012008:Recurrence; D020554:Sperm Injections, Intracytoplasmic