Synthesis, functionalization and photo-Bergman chemistry of enediyne bioconjugates.
Methodology is outlined for the chemical synthesis of versatile photo-Bergman enediyne building blocks and their conjugates. Routes to both mono and bis conjugated enediyne templates are detailed together with representative examples of their bioconjugates, nanoconjugates, PEG derivatives and water soluble salts. The immunocompetence of antibody conjugates is retained, and application in the form of reagents for photodynamic therapy (PDT) advanced.
LaBeaume
Paul
P
Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115, United States.
Wager
Krista
K
Falcone
Danielle
D
Li
Jane
J
Torchilin
Vladimir
V
Castro
Curtis
C
Holewa
Coleen
C
Kallmerten
Amy E
AE
Jones
Graham B
GB
D000906:Antibodies / Q000737:chemistry / Q000276:immunology; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D053281:Enediynes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006046:Gold / Q000737:chemistry; D053768:Metal Nanoparticles / Q000737:chemistry; D017319:Photosensitizing Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011092:Polyethylene Glycols / Q000737:chemistry
D000906:Antibodies; D000970:Antineoplastic Agents; D053281:Enediynes; D017319:Photosensitizing Agents; D011092:Polyethylene Glycols; D006046:Gold