title: [Efficacy of administration of 0.3% pefloxacin solution in the treatment of acute diffuse inflammation of the auditory canal].
abstract: Acute diffuse inflammation of the auditory canal skin is most often caused by gram-negative organisms. Bacteriological analysis of swabs of the auditory canal skin in 70 patients with acute inflammation most frequently found P. aeruginosa, in 64% of patients. Administration of 0.3% pefloxacin solution in the treatment of acute diffuse inflammation of the auditory canal achieved statistically significant therapeutic success in the first five days of treatment, compared to the efficacy of locally applied aminoglykoside pharmaceutical products. Therapeutic success of 10-day local administration of 0.3% pefloxacine solution in 35 investigated patients, estimated by clinical examination, resulted in complete cure in all examinees, while in those treated with standard aminoglycoside drops therapeutic success was registered in 74% of patients. Two properties, low pH and antimicrobial efficacy, primarily on P. aeruginosa, make 0.3% pefloxacin solution an effective drug in the local treatment of acute diffuse inflammation of the auditory canal.
authors: Opca bolnica, 23000 Zadar.
authors: Marijan
authors: M
authors: Kovacić
authors: Boris
authors: B
authors: Dzelalija
mesh_terms: D000208:Acute Disease; D000287:Administration, Topical; D000328:Adult; D000890:Anti-Infective Agents / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010032:Otitis Externa / Q000188:drug therapy* / Q000382:microbiology; D015366:Pefloxacin / Q000008:administration & dosage*; D012996:Solutions; D055815:Young Adult
chemical_list: D000890:Anti-Infective Agents; D012996:Solutions; D015366:Pefloxacin