Adsorption of tripeptide RGD on rutile TiO(2) nanotopography surface in aqueous solution.
Molecular dynamics simulations were carried out to investigate the adsorption mechanisms of tripeptide Arg-Gly-Asp (RGD) on the nanotopography and perfect rutile TiO(2) (110) surfaces in aqueous solution. It is shown that the amino groups (NH(2) and NH3+) and carboxyl group (COO(-)) of RGD are the main groups bonding to hydrophilic TiO(2) surface by electrostatic and van der Waals interactions. It is also demonstrated that RGD adsorbs much more rapidly and stably on the nanotopography surface than the perfect surface. On the hydrophilic TiO(2) surface, the water molecules occupy the adsorption sites to form hydration layers, which have a significant influence on RGD adsorption. On the perfect surface, since the fivefold titanium atom is surrounded by surface bridging oxygen atoms above it and has a water molecule bonding to it, the amino group NH(2) is the adsorption group. However, because the pit surface exposes more adsorption sites and has higher surface energy, RGD can adsorb rapidly on the surfaces by amino groups NH(2) and NH3+, and the carboxyl group COO(-) may edge out the adsorbed water molecules and bond to the surface titanium atom. Moreover, the surface with higher surface energy has more adsorption energy of RGD.
Song
Dai-Ping
DP
Precision Engineering Research Institute, Harbin Institute of Technology, Harbin, China. songdp@yahoo.cn
Chen
Ming-Jun
MJ
Liang
Ying-Chun
YC
Bai
Qing-Shun
QS
Chen
Jia-Xuan
JX
Zheng
Xiong-Fei
XF
D006860:Hydrogen Bonding; D008958:Models, Molecular; D036103:Nanotechnology; D009842:Oligopeptides / Q000737:chemistry*; D012996:Solutions; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry*; D014867:Water
D009842:Oligopeptides; D012996:Solutions; D014867:Water; C009495:titanium dioxide; C047981:arginyl-glycyl-aspartic acid; D014025:Titanium