Fibroadenoma and intraduct papilloma--a common pathogenesis?
This report describes two cases, each showing fibroepithelial proliferation, admixed with intraduct papillomas. Case 1 was from a 13-year-old female who presented with a breast mass, while case 2 was from a 60-year-old female who also had a breast lump. Case 1 showed proliferative breast disease with multiple small papillomas, some with leaf-like contours. Broad-based parenchymal proliferations protruding into ducts were also seen, and there were overlap features between the two ends of this spectrum. Case 2, similarly, demonstrated a mixed intraductal proliferation, with papillomas on narrow stalks together with low-grade phyllode areas extending into ducts from a wider base. That fibroadenoma and intraduct papilloma may have a common pathogenesis is discussed.
Cummings
Margaret C
MC
Molecular and Cellular Pathology, Centre for Clinical Research, University of Queensland, Brisbane, Queensland, Australia. m.cummings@uq.edu.au
da Silva
Leonard
L
Papadimos
David J
DJ
Lakhani
Sunil R
SR
D000293:Adolescent; D001943:Breast Neoplasms / Q000209:etiology / Q000473:pathology*; D005260:Female; D018226:Fibroadenoma / Q000209:etiology / Q000473:pathology*; D006801:Humans; D019394:Ki-67 Antigen / Q000032:analysis; D008875:Middle Aged; D018300:Papilloma, Intraductal / Q000209:etiology / Q000473:pathology*
D019394:Ki-67 Antigen