[Genotype analysis of killer cell immunoglobulin-like receptors in Graves' disease patients].
OBJECTIVE
Killer cell immunoglobulin-like receptor (KIR) can modulate the activity of NK and T lymphocyte. To investigate whether the KIR genotype possessing a susceptibility to Graves disease (GD).


METHODS
Using PCR-SSP to detect KIR genotype in 96 GD patients and 96 randomly selected healthy controls.


RESULTS
The genotype frequency of 2DS2-, 2DL2-, 2DL3+, 2DL1+, 3DL1+, 3DS1-, 2DL5-, 2DS3-, 2DS5-, 2DS1-, 2DS4- was significantly higher in the patient group compared to that of the control group (6.25% vs 0%, P<0.05). Genotype of 2DS2-, 2DL2-, 2DL3+, 2DL1+, 3DL1+, 3DS1-, 2DL5-, 2DS3-, 2DS5-, 2DS1-, 2DS4+ is the most prevalent in the controls (28.13% vs 10.42%, P<0.01). Genotypes without activating KIR genes have higher frequency in patient group.


CONCLUSIONS
The difference of KIR genotypes between GD patients and healthy controls may explain the pathogenesis of GD.
Zhang
Hai-qing
HQ
Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, China. haiqingzhang7576@163.com
Zhao
Jia-jun
JJ
Zhao
Yue-ran
YR
Guan
Qing-bo
QB
Gao
Ling
L
Song
Huai-dong
HD
D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006111:Graves Disease / Q000235:genetics* / Q000276:immunology; D006801:Humans; D008297:Male; D054340:Receptors, KIR / Q000235:genetics* / Q000276:immunology
D054340:Receptors, KIR