In vitro inhibitory effects of palmatine from Enantia chlorantha on Trypanosoma cruzi and Leishmania infantum.
In an attempt to establish the components responsible for the use of Enantia chlorantha against cutaneous leishmaniasis in local traditional medicine, a well-known palmatine has been isolated in substantial amounts from a methanolic bark extract of this plant species. Palmatine therein obtained exhibited a significant inhibitory activity on growth of both Trypanosoma cruzi (IC(50) 0.068 microM) and Leishmania infantum (IC(50) 0.79 microM).
Nkwengoua
Ernestine Tchouboun
ET
Faculty of Science, Laboratory of Bio-Organic and Medicinal Chemistry, Department of Organic Chemistry, University of Yaounde I, Yaounde, Cameroon.
Ngantchou
Igor
I
Nyasse
Barthélemy
B
Denier
Colette
C
Blonski
Casimir
C
Schneider
Bernd
B
D000818:Animals; D029061:Annonaceae / Q000737:chemistry*; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001600:Berberine Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018314:Leishmania infantum / Q000187:drug effects*; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014344:Trypanocidal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014349:Trypanosoma cruzi / Q000187:drug effects*
D000981:Antiprotozoal Agents; D001600:Berberine Alkaloids; D010936:Plant Extracts; D014344:Trypanocidal Agents; C005413:palmatine