[Biphenotypic acute leukaemia with Burkitt-like cytology].
Biphenotypic acute leukaemia (BAL) represents about 5% of adult acute leukaemia. Based on a previously described scoring system, the European Group for Immunologic Classification of Leukaemia (EGIL) proposed a set of diagnostic criteria for BAL. This scoring system is based on the number and degree of the specificity of several markers for myeloid or T/B lymphoid blasts. Here, we report the case of a BAL with Burkitt-like cytology, corresponding to "the acute lymphoblastic leukaemia, Burkitt type" L3 for the FAB classification. By flow cytometry, the blasts showed a positivity for B lymphoid cytoplasmic (CD79a and mu) and membrane (CD19, CD22, CD24, IgM) markers AND a positivity for the myeloid (CD13, CD33, CD65, CD15) markers.
Coche
D
D
Laboratoire d'hématologie, CHU Nord, Amiens.
Bergues
B
B
Harrivel
V
V
Guillaume
N
N
D000328:Adult; D001752:Blast Crisis / Q000473:pathology; D002051:Burkitt Lymphoma / Q000473:pathology; D005434:Flow Cytometry / Q000379:methods; D006801:Humans; D015456:Leukemia, Biphenotypic, Acute / Q000145:classification / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology