title: Analysis of a non-synonymous single nucleotide polymorphism of the human diamine oxidase gene (ref. SNP ID: rs1049793) in patients with Crohn's disease.
abstract: OBJECTIVE
  To analyse the possible influence of a non-synonymous single nucleotide polymorphism (SNP) of the histamine-degrading enzyme diamine oxidase (DAO) on genetic susceptibility to Crohn's disease (CD).
  
  
  METHODS
  In this prospective, case-control study, 210 unrelated Caucasian consecutive CD patients were recruited at the Inflammatory Bowel Disease Unit of a single tertiary centre (Hospital Clínico San Carlos) in Madrid, Spain. A total of 261 healthy volunteers from the same geographic area were also recruited and matched with patients. Both cases and controls were analysed for the presence of a non-synonymous SNP (rs1049793) of DAO using amplification-restriction procedures of the genotype obtained in a blood sample.
  
  
  RESULTS
  No significant differences were found in the distribution of carriers of the non-synonymous SNP of DAO between CD patients and controls (OR 1.2 (95% CI 0.9-1.6; p=0.3)). Nor were any differences found between carriers and non-carriers of the non-synonymous SNP in demographic characteristics, phenotypes, complications or treatment of CD.
  
  
  CONCLUSIONS
  The study of a non-synonymous SNP (rs1049793) of DAO does not seem to be of use in assessing susceptibility to CD, either as a marker of disease activity or as a marker of clinical behaviour in patients with the disease.
authors: Service of Gastroenterology, Hospital Clínico San Carlos, Complutense University, Madrid, Spain. natalia.lopa@gmail.com
authors: Natalia
authors: N
authors: López Palacios
authors: José A G
authors: JA
authors: Agúndez
authors: Juan L
authors: JL
authors: Mendoza
authors: Elena
authors: E
authors: García-Martín
authors: Carmen
authors: C
authors: Martínez
authors: Manuel Enrique
authors: ME
authors: Fuentes Ferrer
authors: José M
authors: JM
authors: Ladero
authors: Carlos
authors: C
authors: Taxonera
authors: Manuel
authors: M
authors: Díaz-Rubio
mesh_terms: D000328:Adult; D006631:Amine Oxidase (Copper-Containing) / Q000235:genetics*; D016022:Case-Control Studies; D003424:Crohn Disease / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
chemical_list: D006631:Amine Oxidase (Copper-Containing)