Linking amyloid and tau pathology in Alzheimer's disease: the role of membrane cholesterol in Abeta-mediated tau toxicity.
Wray
Selina
S
Department of Molecular Neuroscience, UCL Institute of Neurology, London WC1N 3BG, United Kingdom. S.Wray@ion.ucl.ac.uk
Noble
Wendy
W
D000375:Aging; D000544:Alzheimer Disease / Q000178:diet therapy / Q000503:physiopathology*; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism; D002154:Calpain / Q000378:metabolism; D016923:Cell Death / Q000187:drug effects / Q000502:physiology; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism*; D002784:Cholesterol / Q000378:metabolism*; D006624:Hippocampus / Q000187:drug effects / Q000503:physiopathology; D006801:Humans; D009410:Nerve Degeneration / Q000188:drug therapy / Q000503:physiopathology; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D015398:Signal Transduction; D047392:beta-Cyclodextrins / Q000494:pharmacology; D016875:tau Proteins / Q000378:metabolism*
D016229:Amyloid beta-Peptides; C054369:MAPT protein, human; D047392:beta-Cyclodextrins; C108732:methyl-beta-cyclodextrin; D016875:tau Proteins; D002784:Cholesterol; D002154:Calpain; D002118:Calcium