title: Assessment of pro-vasopressin and pro-adrenomedullin as predictors of 28-day mortality in septic shock patients.
abstract: OBJECTIVE
  Improvements in survival after septic shock will most likely rely on our capacity to manage individualized therapies based on the measurement of rapidly accessible biomarkers. As the early phase of septic shock is dominated by severe alterations of the cardiovascular system, the predictive value for mortality of pro-vasopressin (pro-AVP) and pro-adrenomedullin (pro-ADM), two vasoactive pro-hormones, was assessed.
  
  
  METHODS
  In 99 consecutive patients, pro-hormone concentrations were measured (immunoluminometric assay) three times within the first week after the onset of septic shock.
  
  
  RESULTS
  Pro-AVP and pro-ADM concentrations were significantly increased in non-survivors in comparison with survivors and were significantly associated with mortality after both univariate and multivariate analysis. Importantly, when assessed as a pair, pro-ADM and pro-AVP were even more informative.
  
  
  CONCLUSIONS
  Both Pro-ADM and pro-AVP appear to be good biomarkers for the prediction of 28-day mortality after septic shock. However, their association in a single variable tends to improve their predictive capacity.
authors: Flow Cytometry Unit, Immunology Laboratory, Hôpital E. Herriot, Hospices Civils de Lyon, 5, Place d'Arsonval, 69437, Lyon cedex 03, France.
authors: Caroline
authors: C
authors: Guignant
authors: Nicolas
authors: N
authors: Voirin
authors: Fabienne
authors: F
authors: Venet
authors: Françoise
authors: F
authors: Poitevin
authors: Christophe
authors: C
authors: Malcus
authors: Julien
authors: J
authors: Bohé
authors: Alain
authors: A
authors: Lepape
authors: Guillaume
authors: G
authors: Monneret
mesh_terms: D053607:Adrenomedullin / Q000097:blood*; D000368:Aged; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood*; D005260:Female; D005602:France / Q000453:epidemiology; D006020:Glycopeptides / Q000097:blood*; D006801:Humans; D007118:Immunoassay; D053208:Kaplan-Meier Estimate; D016015:Logistic Models; D008163:Luminescent Measurements; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D011498:Protein Precursors / Q000097:blood*; D012372:ROC Curve; D018570:Risk Assessment; D012720:Severity of Illness Index; D012772:Shock, Septic / Q000097:blood / Q000401:mortality; D018709:Statistics, Nonparametric
chemical_list: D015415:Biomarkers; D006020:Glycopeptides; D011498:Protein Precursors; C048197:copeptins; C088633:proadrenomedullin; D053607:Adrenomedullin