title: A case of childhood acute myeloid leukemia AML (M5) with a neocentric chromosome neo(1)(qter-->q23 approximately 24::q23 approximately 24-->q43-->neo-->q43-->qter) and tetrasomy of chromosomes 8 and 21.
abstract: Hyperdiploidy is rarely observed in childhood acute myeloid leukemia (AML). Described here is the case of a 2(1/2)-year-old girl with AML-M5 and 51 chromosomes characterized by double tetrasomy of chromosomes 8 and 21 and also a neocentric derivative chromosome neo(1)(qter-->q23 approximately 24::q23 approximately 24-->q43-->neo-->q43-->qter). Little is known about the prognostic significance of these chromosomal abnormalities in childhood AML. In the actual case, complete remission was achieved after chemotherapy, which continued for 7 months. No acquired neocentric chromosome 1 has been described previously, even though neocentromere formation has been reported for other chromosomes in neoplasms.
authors: Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro (U.F.R.J.), Rio de Janeiro, RJ, Brazil.
authors: Amanda Faria
authors: AF
authors: de Figueiredo
authors: Hasmik
authors: H
authors: Mkrtchyan
authors: Thomas
authors: T
authors: Liehr
authors: Eliane Maria
authors: EM
authors: Soares Ventura
authors: Terezinha
authors: T
authors: de Jesus Marques-Salles
authors: Neide
authors: N
authors: Santos
authors: Raul Corrêa
authors: RC
authors: Ribeiro
authors: Eliana
authors: E
authors: Abdelhay
authors: Maria Luiza
authors: ML
authors: Macedo Silva
mesh_terms: D002675:Child, Preschool; D002869:Chromosome Aberrations; D002891:Chromosomes, Human, Pair 21; D002898:Chromosomes, Human, Pair 8; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics*