A little bit of sugar makes polycomb better.
Transcriptional repression by Polycomb group (PcG) proteins is now sweetened by the discovery of the essential role of O-GlcNAc glycosylation in the process. PcG protein polyhomeotic may be the key target, but alternative or additional functions including repression of transcription through glycosylation of the C-terminal domain of RNA polymerase II are also possible.
Schwartz
Yuri B
YB
Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854, USA. schwartz@biology.rutgers.edu
Pirrotta
Vincenzo
V
D000818:Animals; D050260:Carbohydrate Metabolism; D029721:Drosophila Proteins / Q000378:metabolism; D004331:Drosophila melanogaster / Q000378:metabolism; D006031:Glycosylation; D063146:Polycomb-Group Proteins; D011485:Protein Binding; D012097:Repressor Proteins / Q000378:metabolism*; D020218:Response Elements / Q000235:genetics
D029721:Drosophila Proteins; D063146:Polycomb-Group Proteins; D012097:Repressor Proteins