title: A dutch family with Hb Debrousse: severe anemia after parvovirus B19 infection.
abstract: Hb Debrousse [beta96(FG3)Leu-->Pro] is an unstable hemoglobin (Hb) variant with high oxygen affinity. We describe a case of chronic compensated hemolysis in a 39-year-old woman in whom the variant was found. Soon after the diagnosis was made, she and her son were admitted to the hospital with severe anemia due to Parvovirus B19 infection. The son also appeared to have the Hb Debrousse variant. Parvovirus B19 infection is a life-threatening disease in patients with (compensated) hemolysis.
authors: Department of Internal Medicine, Meander Medical Centre, Amersfoort, The Netherlands. pvanbalen@ziggo.nl
authors: Peter
authors: P
authors: van Balen
authors: Merel
authors: M
authors: van Wijnen
authors: Paul H G
authors: PH
authors: Hogeman
authors: Shulamiet
authors: S
authors: Wittebol
mesh_terms: D000328:Adult; D000743:Anemia, Hemolytic / Q000097:blood / Q000209:etiology / Q000235:genetics*; D005192:Family Health; D005260:Female; D006455:Hemoglobins, Abnormal / Q000235:genetics*; D006801:Humans; D009154:Mutation; D009426:Netherlands; D010322:Parvoviridae Infections / Q000150:complications* / Q000821:virology; D016732:Parvovirus B19, Human; D055544:beta-Globins / Q000235:genetics
chemical_list: D006455:Hemoglobins, Abnormal; D055544:beta-Globins; C098868:hemoglobin Debrousse