Clinical and genetic characteristics of Mexican Huntington's disease patients.
We report the characteristics of 691 Mexican patients with Huntington's disease (HD). These patients, representing 401 families, constitute the largest series of Mexican HD cases as yet described in the literature. We found the clinical characteristics of these patients to be similar to those of other populations, but we observed a higher frequency of infantile cases, a shorter disease duration and a lower suicide rate. In 626 cases, for which molecular analyses were available, CAG-trinucleotide expansion size ranged from 37-106 repeats. The large number of CAG repeats (19.04 +/- 3.02) in normal alleles and the presence of new mutations suggest that the overall prevalence of HD in the Mexican population could be expected to be within range of, or higher than, that reported for Europeans.
Alonso
María Elisa
ME
Department of Neurogenetics and Molecular Biology, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Insurgentes Sur 3877, Col. La Fama, Tlalpan, 14269 Mexico, D. F., Mexico. elisaav@servidor.unam.mx
Ochoa
Adriana
A
Boll
Marie-Catherine
MC
Sosa
Ana Luisa
AL
Yescas
Petra
P
López
Marisol
M
Macias
Rosario
R
Familiar
Itziar
I
Rasmussen
Astrid
A
D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000368:Aged; D002648:Child; D002675:Child, Preschool; D003431:Cross-Cultural Comparison; D005192:Family Health; D005260:Female; D006801:Humans; D006816:Huntington Disease / Q000235:genetics* / Q000503:physiopathology*; D008297:Male; D008800:Mexico / Q000453:epidemiology / Q000208:ethnology; D012189:Retrospective Studies; D013223:Statistics as Topic; D019680:Trinucleotide Repeat Expansion / Q000235:genetics*; D055815:Young Adult