The cell cycle and Myc intersect with mechanisms that regulate pluripotency and reprogramming.
Pluripotent stem cells have long-term proliferative capacity and an unusual mode of cell-cycle regulation and can divide independently of extrinsic mitogenic signals. The last few years has seen evidence emerge that links cell-cycle regulation to the maintenance and establishment of pluripotency. Myc transcription factors appear to be central to this regulation. This review addresses these links and discusses how cell-cycle controls and Myc impact on the maintenance and establishment of pluripotency.
Singh
Amar M
AM
Department of Biochemistry and Molecular Biology, Paul D. Coverdell Center for Biomedical and Health Sciences, The University of Georgia, Athens, GA 30602, USA.
Dalton
Stephen
S
D000818:Animals; D002453:Cell Cycle / Q000502:physiology*; D002454:Cell Differentiation / Q000502:physiology*; D049109:Cell Proliferation; D065150:Cellular Reprogramming / Q000502:physiology*; D006801:Humans; D039904:Pluripotent Stem Cells / Q000502:physiology*; D016271:Proto-Oncogene Proteins c-myc / Q000502:physiology*
D016271:Proto-Oncogene Proteins c-myc