title: Molecular markers of susceptibility to ocular toxoplasmosis, host and guest behaving badly.
abstract: Infection with Toxoplasma gondii results in retinochoroiditis in 6% to 20% of immunocompetent individuals. The outcome of infection is the result of a set of interactions involving host genetic background, environmental, and social factors, and the genetic background of the parasite, all of which can be further modified by additional infections or even reinfection. Genes that encode several components of the immune system exhibit polymorphisms in their regulatory and coding regions that affect level and type of expression in response to stimuli, directing the immune response into different pathways. These variant alleles have been associated with susceptibility to immune-mediated diseases and with severity of pathology. We have investigated polymorphisms in several of these genes, identified as candidates for progression to retinochoroiditis caused by toxoplasmosis, namely chemokine (C-C motif) receptor 5 (CCR5), toll-like receptor-2 (TLR2), and TLR4. Furthermore, because interleukin-12 (IL-12) has been shown to be fundamental both in mice and in man to control a protective response against T. gondii, molecules that have a key function in IL-12 production will be emphasized in this review, in addition to discussing the importance of the genetic background of the parasite in the establishment of ocular disease.
authors: Oswaldo Cruz Institution (IOC), Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, RJ, Brazil.
authors: Adriana Lima
authors: AL
authors: Vallochi
authors: Anna Carla
authors: AC
authors: Goldberg
authors: Angela
authors: A
authors: Falcai
authors: Rajendranath
authors: R
authors: Ramasawmy
authors: Jorge
authors: J
authors: Kalil
authors: Cláudio
authors: C
authors: Silveira
authors: Rubens
authors: R
authors: Belfort
authors: Luiz Vicente
authors: LV
authors: Rizzo