title: A single nucleotide polymorphism in the porcine cathepsin K (CTSK) gene is associated with back fat thickness and production traits in Italian Duroc pigs.
abstract: Cathepsin K (CTSK) was selected as a candidate gene for fat deposition in pigs because recently, in human and mouse, it was shown that this lysosomal proteinase is an obesity marker. A single nucleotide polymorphism (SNP) was identified in intron 4 of the porcine CTSK gene (g.15G>A; FM209043). Allele frequencies of this polymorphism were analysed in seven pig breeds. Radiation hybrid mapping confirmed the localization of CTSK to porcine chromosome 4, close to the FAT1 QTL region. Three populations of pigs (one Italian Large White and two Italian Duroc groups of pigs) were selected for association analysis. In the Italian Large White breed the g.15G>A SNP was not informative. Association analysis including all Italian Duroc pigs showed that the CTSK marker was associated with back fat thickness and lean cuts (P < 0.01), and average daily gain and feed:gain ratio (P < 0.05) estimated breeding values.
authors: DIPROVAL, Sezione di Allevamenti Zootecnici, Faculty of Agriculture, University of Bologna, Reggio Emilia, Italy. luca.fontanesi@unibo.it
authors: Luca
authors: L
authors: Fontanesi
authors: Emilio
authors: E
authors: Scotti
authors: Luca
authors: L
authors: Buttazzoni
authors: Stefania
authors: S
authors: Dall'Olio
authors: Roberta
authors: R
authors: Davoli
authors: Vincenzo
authors: V
authors: Russo
mesh_terms: D050154:Adiposity / Q000235:genetics*; D000818:Animals; D001947:Breeding; D056657:Cathepsin K / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D007558:Italy; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D019655:Quantitative Trait, Heritable; D034421:Sus scrofa / Q000235:genetics*
chemical_list: D056657:Cathepsin K