Selected testosterone-related diseases in women who have given birth to a child with infantile autism.
OBJECTIVE
The objective of the current study was to compare the prevalence of three testosterone-related cancer diseases in the mothers of 111 individuals diagnosed as children with infantile autism (IA) with a matched comparison group of mothers of 330 children from the general population.


METHODS
All mothers were screened through the nationwide Danish National Hospital Register. We inquired about breast-, uterine-, and ovarian cancer diseases during an observation period of 27 years.


RESULTS
At follow up a similar proportion of case and control mothers had a diagnosis of any cancer disease: 6.3% vs 8.5%. In addition, no single cancer disease was significantly more frequent among mothers of children with IA.


CONCLUSIONS
Our study provides no support for an (eventually androgen-mediated) increased rate of cancer in mothers of persons with IA.
Mouridsen
Svend Erik
SE
Department of Child and Adolescent Psychiatry, Bispebjerg University Hospital, Copenhagen, Denmark. sem01@bbh.hosp.dk
Rich
Bente
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Isager
Torben
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D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001321:Autistic Disorder / Q000453:epidemiology* / Q000503:physiopathology; D001943:Breast Neoplasms / Q000453:epidemiology / Q000503:physiopathology; D002648:Child; D016241:Child of Impaired Parents / Q000706:statistics & numerical data*; D002675:Child, Preschool; D003718:Denmark / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D005833:Genital Neoplasms, Female / Q000453:epidemiology* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009035:Mothers / Q000706:statistics & numerical data; D010051:Ovarian Neoplasms / Q000453:epidemiology / Q000503:physiopathology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000453:epidemiology*; D015995:Prevalence; D017678:Sex Distribution; D013739:Testosterone / Q000502:physiology*; D014594:Uterine Neoplasms / Q000453:epidemiology* / Q000503:physiopathology
D013739:Testosterone