Cyclosporin treatment in three children with chronic inflammatory demyelinating neuropathy.
Chronic inflammatory demyelinating neuropathy is an uncommon acquired polyneuropathy in children. Oral prednisolone, intravenous methyl prednisolone, and intravenous immunoglobulin are its main initial therapies. In patients resistant to these modalities, other immunosuppressants can be used. We demonstrate the efficacy of cyclosporin in three children with chronic inflammatory demyelinating neuropathy. Two of them were infants. None had adverse effects, except for hirsutism. We conclude that cyclosporin treatment can be effective and safe in chronic inflammatory demyelinating neuropathy, when standard treatments are ineffective. Cyclosporin can also be used safely in infants.
Hergüner
M Ozlem
MO
Department of Pediatric Neurology, Cukurova University, 01330 Balcali, Adana, Turkey. oherguner@hotmail.com
Incecik
Faruk
F
Altunbaşak
Sakir
S
D002675:Child, Preschool; D002908:Chronic Disease; D016572:Cyclosporine / Q000009:adverse effects / Q000627:therapeutic use*; D003711:Demyelinating Diseases / Q000188:drug therapy*; D005260:Female; D006628:Hirsutism / Q000139:chemically induced; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D007223:Infant; D008297:Male; D011115:Polyneuropathies / Q000188:drug therapy*; D016896:Treatment Outcome
D007166:Immunosuppressive Agents; D016572:Cyclosporine