A catalytic synthesis of selectively substituted biaryls through sequential intermolecular coupling involving arene and ketone C-H bond functionalization.
Selectively substituted biaryls containing a ketone unit are obtained under mild conditions in satisfactory yields by a simple reaction of ortho-substituted aryl iodides and ketones in the presence of palladium and norbornene as catalysts.
Maestri
Giovanni
G
Dipartimento di Chimica Organica e Industriale and CIRCC, Università di Parma, V.le G. P. Usberti, 17/A, 43100 Parma, Italy.
Della Ca'
Nicola
N
Catellani
Marta
M