title: Clinical and histopathological features of remnant gastric cancers, after gastrectomy for synchronous multiple gastric cancers.
abstract: BACKGROUND
  Remnant gastric cancers have been extensively investigated; however, little has been unveiled the features of remnant gastric cancers with regard to the existence of synchronous multiple lesions. We evaluated the clinicopathological features of remnant gastric cancers, after initial gastrectomy for both single and multiple gastric cancers.
  
  
  METHODS
  We retrospectively analyzed 3,042 patients diagnosed with gastric cancers who underwent gastrectomy. Of these, total gastrectomy cases were excluded, and remaining 2,120 cases were investigated.
  
  
  RESULTS
  Among the 2,120 patients, 1,967 patients were histopathologically diagnosed with solitary lesion and 153 patients with multiple lesions. The incidence of remnant gastric cancers was higher in patients with multiple lesions at initial surgery than those with solitary lesion (P < 0.05). Moreover, remnant cancers developed within shorter duration of follow-up after treatment of synchronous multiple lesions compared to those that developed after treatment of solitary lesions (P = 0.05). Among the patients treated for synchronous multiple lesions, distance from the oral margin was a potential risk factor for the development of secondary cancers in the remnant stomach.
  
  
  CONCLUSIONS
  Patients with synchronous multiple gastric cancers are more susceptible to the development of secondary cancers in their remnant stomach. These patients need careful follow-up after initial gastrectomy.
authors: Division of Digestive Surgery, National Cancer Center Hospital East, Kashiwa, Chiba 277-8577, Japan. takfujit@east.ncc.go.jp
authors: Takeo
authors: T
authors: Fujita
authors: Naoto
authors: N
authors: Gotohda
authors: Shinichiro
authors: S
authors: Takahashi
authors: Toshio
authors: T
authors: Nakagohri
authors: Masaru
authors: M
authors: Konishi
authors: Taira
authors: T
authors: Kinoshita
mesh_terms: D000368:Aged; D002277:Carcinoma / Q000473:pathology / Q000601:surgery; D005260:Female; D005743:Gastrectomy; D018530:Gastric Stump / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000473:pathology* / Q000601:surgery*; D012189:Retrospective Studies; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000473:pathology* / Q000601:surgery*