Radiation crosslinked polymerization of methacrylamide and psyllium to develop antibiotic drug delivery device.
Psyllium is a medicinally important polysaccharide and its modification with methacrylamide through radiation crosslinked polymerization will develop hydrogels meant for drug delivery applications. The present paper deals with the preparation of hydrogels and their characterization by SEMs, FTIR, TGA and swelling studies. The release dynamics of model antibiotic drug rifampicin from the hydrogels has been studied for the evaluation of the release mechanism. The values of the diffusion exponent 'n' have been obtained (0.64, 0.58 and 0.57), respectively, in distilled water, pH 2.2 buffer and pH 7.4 buffer. The release of the drug from the hydrogels occurred through non-Fickian diffusion mechanism.
Singh
Baljit
B
Department of Chemistry, Himachal Pradesh University, Shimla 171005, India. baljitsinghhpu@yahoo.com
Sharma
Vikrant
V
Kumar
Anil
A
Kumar
Sanjay
S
D000178:Acrylamides / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000378:metabolism; D004337:Drug Carriers / Q000737:chemistry*; D020100:Hydrogels / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008855:Microscopy, Electron, Scanning; D011108:Polymers / Q000737:chemistry*; D011620:Psyllium / Q000737:chemistry*; D011827:Radiation; D011829:Radiation Dosage; D012293:Rifampin / Q000737:chemistry / Q000378:metabolism; D012965:Sodium Chloride / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature; D013818:Thermogravimetry; D014867:Water / Q000737:chemistry
D000178:Acrylamides; D000900:Anti-Bacterial Agents; D004337:Drug Carriers; D020100:Hydrogels; D011108:Polymers; D014867:Water; D012965:Sodium Chloride; D011620:Psyllium; C045985:methacrylamide; D012293:Rifampin