title: [A case of primary gastric mantle cell lymphoma].
abstract: Endoscopic examination of a 60-year-old man revealed multiple erosions in the gastric antrum. After 6 months, erosions also formed in the duodenal bulb and systemic lymph nodes become enlarged. After 20 months, the gastroduodenal erosions developed into mucosal ulcers, and the systemic lymph node swelling progressed. Histological examination of the neck lymph node showed mantle cell lymphoma (MCL). This result agreed with the results of the gastroduodenal biopsy. This case was diagnosed as recurrent primary gastric MCL in other areas, with systemic lymph node metastasis and bone marrow invasion. Hyper-CVAD (cyclophosphamide, doxorubicin, vincristine, and dexamethasone), high-dose methotrexate and cytarabine in combination with Rituximab and stem cell transplantation was performed. The gastroduodenal lesions and atypical cells in the bone marrow disappeared after 2 cycles of the chemotherapy. Metastatic lymph node swelling regressed after stem cell transplantation. We have had no evidence of recurrence for 50 months. Primary gastric MCL is very rare and cyclin D1 immunohistochemistry and FISH assay were very useful for the diagnosis of MCL.
authors: Department of Gastroenterology, Miyagi Cancer Center, Japan. tohru-kikuchi@nifty.com
authors: Tohru
authors: T
authors: Kikuchi
authors: Naoko
authors: N
authors: Asano
authors: Tetsuya
authors: T
authors: Noguchi
authors: Eiki
authors: E
authors: Nomura
authors: Kiyoshi
authors: K
authors: Uchimi
authors: Hirohumi
authors: H
authors: Kagaya
authors: Shinichi
authors: S
authors: Suzuki
authors: Masaki
authors: M
authors: Suzuki
authors: Yoshiro
authors: Y
authors: Kayaba
authors: Hiroo
authors: H
authors: Tateno
authors: Hiroyoshi
authors: H
authors: Onodera
mesh_terms: D003131:Combined Modality Therapy; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D020522:Lymphoma, Mantle-Cell / Q000188:drug therapy / Q000473:pathology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000628:therapy