The role of antihistamines in the new millennium.
Histamine, a pivotal mediator of inflammation, has been the target of therapeutic intervention in allergic disorders for the better part of the past century. During this time, the benefit-to-risk profiles of H1-receptor antagonists have improved. This review explores the pharmacologic properties of these agents, their roles in treating allergic disorders, their safety, and the avenues of future inquiry that might further define their therapeutic possibilities.
Simons
F E
FE
Children's Hospital, Winnipeg, Manitoba, Canada R3A 1S1. lmcniven@hsc.mb.ca
D001249:Asthma / Q000188:drug therapy; D002986:Clinical Trials as Topic; D005221:Fatigue / Q000139:chemically induced; D006632:Histamine / Q000502:physiology; D006633:Histamine Antagonists / Q000494:pharmacology*; D006634:Histamine H1 Antagonists / Q000494:pharmacology; D006636:Histamine Release / Q000187:drug effects; D006801:Humans; D006967:Hypersensitivity / Q000188:drug therapy / Q000503:physiopathology; D012220:Rhinitis / Q000188:drug therapy
D006633:Histamine Antagonists; D006634:Histamine H1 Antagonists; D006632:Histamine