Influence of surface chemistry of mesoporous alumina with wide pore distribution on controlled drug release.
The crucial role of the drug carrier surface chemical moeities on the uptake and in vitro release of drug is discussed here in a systematic manner. Mesoporous alumina with a wide pore size distribution (2-7 nm) functionalized with various hydrophilic and hydrophobic surface chemical groups was employed as the carrier for delivery of the model drug ibuprofen. Surface functionalization with hydrophobic groups resulted in low degree of drug loading (approximately 20%) and fast rate of release (85% over a period of 5 h) whereas hydrophilic groups resulted in a significantly higher drug payloads (21%-45%) and slower rate of release (12%-40% over a period of 5 h). Depending on the chemical moiety, the diffusion controlled ( proportional, varianttime(-)(0.5)) drug release was additionally observed to be dependent on the mode of arrangement of the functional groups on the alumina surface as well as on the pore characteristics of the matrix. For all mesoporous alumina systems the drug dosages were far lower than the maximum recommended therapeutic dosages (MRTD) for oral delivery. We envisage that the present study would aid in the design of delivery systems capable of sustained release of multiple drugs.
Kapoor
Shobhna
S
Solid State and Structural Chemistry Unit, Indian Institute of Science, Bangalore 560012, India.
Hegde
Rajesh
R
Bhattacharyya
Aninda J
AJ
D000537:Aluminum Oxide / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000032:analysis* / Q000737:chemistry; D004337:Drug Carriers / Q000032:analysis* / Q000737:chemistry; D016503:Drug Delivery Systems; D006863:Hydrogen-Ion Concentration; D057927:Hydrophobic and Hydrophilic Interactions; D007052:Ibuprofen / Q000032:analysis* / Q000737:chemistry; D007700:Kinetics; D008956:Models, Chemical; D004364:Pharmaceutical Preparations / Q000032:analysis* / Q000737:chemistry; D016062:Porosity; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties; D013696:Temperature; D013818:Thermogravimetry; D014961:X-Ray Diffraction
D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004364:Pharmaceutical Preparations; D000537:Aluminum Oxide; D007052:Ibuprofen