Efficacy and safety of the combination of docetaxel (Taxotere) with targeted therapies in the treatment of solid malignancies.
Docetaxel is a chemotherapeutic drug which has recently demonstrated high efficacy in the treatment of a wide variety of tumors. Numerous novel targeted drugs are being introduced in preclinical and clinical practice, aiming to directly inhibit pathways responsible for the maintenance of transformed and immortalized phenotypes of cancer cells. Herein we reported the efficacy and safety results of the most significant clinical trials evaluating different combinations and schedules of docetaxel plus biological therapeutics.
Chiuri
Vincenzo Emanuele
VE
Oncologia Medica, Ospedale 'V. Fazzi', Pizza F. Muratore, 73100 Lecce, Italy. chiuriv@yahoo.it
Silvestris
Nicola
N
Lorusso
Vito
V
Tinelli
Andrea
A
D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D001688:Biological Products / Q000008:administration & dosage; D002986:Clinical Trials as Topic; D000077143:Docetaxel; D016503:Drug Delivery Systems; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000503:physiopathology; D010641:Phenotype; D043823:Taxoids / Q000008:administration & dosage
D001688:Biological Products; D043823:Taxoids; D000077143:Docetaxel