title: Objective assessments of allergic and nonallergic rhinitis in young children.
abstract: BACKGROUND
  Allergic and nonallergic rhinitis are common childhood disorders.
  
  
  OBJECTIVE
  To study nasal eosinophilia and nasal airway patency in young children with allergic and nonallergic rhinitis to assess the pathology behind such diagnoses.
  
  
  METHODS
  We investigated 255 children at six years of age from the Copenhagen Prospective Study on Asthma in Childhood birth cohort assessing rhinitis history, specific immunoglobulin E relevant to rhinitis symptoms, nasal eosinophilia and nasal airway patency by acoustic rhinometry before and after decongestion. Associations were studied in a multivariate graphical model corrected for gender, height and nasal steroid usage.
  
  
  RESULTS
  Allergic rhinitis was significantly and directly associated with irreversible nasal airway obstruction (reduced decongested nasal airway patency) (P = 0.004), whereas nonallergic rhinitis was not. Both allergic rhinitis (P = 0.000) and nonallergic rhinitis (P = 0.014) were directly and significantly associated with nasal eosinophilia, but this association was stronger for allergic rhinitis.
  
  
  CONCLUSIONS
  Allergic rhinitis and nonallergic rhinitis are of different pathologies as suggested from their different associations not only to allergy but importantly also to irreversible nasal airway obstruction and eosinophilic inflammation. Allergic rhinitis was significantly associated with nasal eosinophilia and irreversible nasal airway obstruction suggesting chronic inflammation and structural remodeling of the nasal mucosa in children at the age of 6 years. Nonallergic rhinitis exhibited no change in the nasal airway patency, but some nasal mucosal eosinophilia albeit less than children with allergic rhinitis.
authors: Danish Pediatric Asthma Center, Copenhagen University Hospital, Gentofte Copenhagen, Denmark.
authors: B L K
authors: BLK
authors: Chawes
authors: Danish Pediatric Asthma Center, Copenhagen University Hospital, Gentofte Copenhagen, Denmark.
authors: E
authors: E
authors: Kreiner-Møller
authors: Danish Pediatric Asthma Center, Copenhagen University Hospital, Gentofte Copenhagen, Denmark.
authors: H
authors: H
authors: Bisgaard
mesh_terms: D000485:Allergens / Q000009:adverse effects / Q000276:immunology; D002648:Child; D015331:Cohort Studies; D004802:Eosinophilia / Q000150:complications; D006801:Humans; D015508:Nasal Obstruction / Q000150:complications / Q000473:pathology; D012220:Rhinitis / Q000150:complications / Q000175:diagnosis / Q000473:pathology; D012221:Rhinitis, Allergic, Perennial / Q000150:complications / Q000175:diagnosis / Q000473:pathology; D006255:Rhinitis, Allergic, Seasonal / Q000150:complications / Q000175:diagnosis / Q000473:pathology; D023842:Rhinometry, Acoustic
chemical_list: D000485:Allergens