title: Specific effects of escitalopram on neuroendocrine response.
abstract: OBJECTIVE
  Citalopram, a selective serotonin reuptake inhibitor, is used as a neuroendocrine probe in human subjects to assess serotonin function as reflected in prolactin and plasma cortisol release. Citalopram is a racemic mixture of equal proportions of the S(+) and R(-) enantiomers. Inhibition of serotonin reuptake and, consequently, antidepressant activity is associated, almost exclusively, with the S(+) enantiomer ("escitalopram"). Studies in animal models indicate that the presence of the R(-) isomer may interfere with the serotonin reuptake activity of escitalopram. The current study compared the neuroendocrine effects of citalopram and escitalopram in healthy human volunteers.
  
  
  METHODS
  Plasma cortisol and prolactin levels following a single oral dose of citalopram (40 mg) or escitalopram (20 mg) were compared in samples taken every 15-30 min over a period of 240 min. Plasma citalopram concentration was determined at the same intervals.
  
  
  RESULTS
  Escitalopram and citalopram caused equivalent increases in plasma cortisol and prolactin. The administration of dexamethasone prior to the escitalopram challenge blocked the evoked increase in cortisol.
  
  
  CONCLUSIONS
  This is the first study to prove that a single dose of escitalopram acts centrally and not peripherally, providing further support of the use of oral escitalopram as a probe for brain serotonergic function.
authors: Providence Care Centre-Mental Health Services, Kingston, ON, Canada.
authors: Emily R
authors: ER
authors: Hawken
authors: James A
authors: JA
authors: Owen
authors: Robert W
authors: RW
authors: Hudson
authors: Nicholas J
authors: NJ
authors: Delva
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D018687:Antidepressive Agents, Second-Generation / Q000494:pharmacology*; D019540:Area Under Curve; D015283:Citalopram / Q000494:pharmacology*; D003907:Dexamethasone; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011388:Prolactin / Q000097:blood*; D016037:Single-Blind Method; D013997:Time Factors
chemical_list: D018687:Antidepressive Agents, Second-Generation; D015283:Citalopram; D003907:Dexamethasone; D011388:Prolactin; D006854:Hydrocortisone