Correlation between histocompatibility antigens and recurrent aphthous stomatitis in the Brazilian population.
Recurrent aphthous stomatitis is a common oral mucosa disorder that affects 20% of the world's population, characterized by recurring painful ulcers in the mouth. The diagnosis is primarily based on the patient's clinical history. Inheritance may pose as a risk factor for the disease; however, the studies available are inconclusive as to the results attained, and they vary according to the population studied.


OBJECTIVE
to typify class I and class II HLA molecules and to assess how frequent these molecules are present in the Brazilian population with Recurrent Aphthous Stomatitis, compared to healthy controls.


METHODS
In this prospective, cross-sectional and investigative study, thirty one patients with diagnostic hypothesis of recurrent aphthous stomatitis were seen from February of 2004 to May of 2006. We obtained the DNA from those patients who matched the inclusion criteria and typified their HLA by PCR.


RESULTS
In those patients with Recurrent Minor Aphthous Stomatitis we found statistically significant occurrences of HLA-A33 and HLA-B35.


CONCLUSIONS
HLA-A33 and HLA-B35 may be associated with recurrent minor aphthous stomatitis in the Brazilian's population.
Wilhelmsen
Niels Salles Willo
NS
Medical School, University of São Paulo.
Weber
Raimar
R
Monteiro
Francisco
F
Kalil
Jorge
J
Miziara
Ivan Dieb
ID
D000293:Adolescent; D000328:Adult; D000368:Aged; D001938:Brazil; D016022:Case-Control Studies; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011446:Prospective Studies; D012008:Recurrence; D013281:Stomatitis, Aphthous / Q000235:genetics* / Q000276:immunology; D055815:Young Adult
D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II