Virotherapy against malignant glioma stem cells.
Glioblastoma multiforme, the most common primary intracranial malignancy, is associated with very poor outcome despite advances in surgical techniques and chemo- and radiation therapy. Many novel treatment modalities are being investigated with varying amount of success. Evolution of cancer stem cell hypothesis provides a new venue for developmental therapeutics. In this review, we highlight the literature regarding the existence of glioma stem cells and their characteristics. We also discuss the potential for virotherapy, a novel therapeutic approach utilizing conditionally replicative viruses, to directly target this population of self-renewing cancer stem cells.
Dey
Mahua
M
The Brain Tumor Center, The University of Chicago, Chicago, IL, USA.
Ulasov
Ilya V
IV
Lesniak
Maciej S
MS
D049109:Cell Proliferation; D005910:Glioma / Q000628:therapy* / Q000821:virology; D006801:Humans; D009367:Neoplasm Staging; D014411:Neoplastic Stem Cells / Q000166:cytology* / Q000821:virology*; D050130:Oncolytic Virotherapy / Q000639:trends; D014779:Virus Replication