title: Tricking melanoma to self-digest: a deal of a meal!
abstract: Melanoma cells acquire multiple genetic and epigenetic alterations that promote their metastasis and resistance to available therapies. In this issue of Cancer Cell, Soengas and colleagues reveal that the induction of endosome-mediated autophagy results in efficient melanoma cell death, thereby offering new potential means for treatment of this devastating cancer.
authors: Signal Transduction Program, Burnham Institute for Medical Research, La Jolla, CA 92130, USA.
authors: Hyungsoo
authors: H
authors: Kim
authors: Ze'ev
authors: Z
authors: Ronai
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects / Q000235:genetics / Q000276:immunology; D011992:Endosomes / Q000187:drug effects / Q000235:genetics / Q000378:metabolism; D006801:Humans; D007113:Immunity, Innate; D008545:Melanoma / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D051379:Mice; D010588:Phagosomes / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D011066:Poly C / Q000494:pharmacology* / Q000627:therapeutic use; D011094:Polyethyleneimine / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D011066:Poly C; D011094:Polyethyleneimine