Anti-inflammatory activity of a polyphenolic enriched extract of Schima wallichii bark.
In the present investigation, the anti-inflammatory activity of a polyphenolic enriched extract of Schima wallichii bark was evaluated in vitro using human peripheral blood mononuclear cells (PBMCs) and in vivo by carrageenan-induced paw oedema assay (acute study) and cotton pallet granuloma assay (chronic study). The extract exhibited significant inhibition of the production of tumour necrotic factor-α and interleukin-6 by PBMCs stimulated with lipopolysaccharide (LPS) in a concentration-dependent manner. The extract at the selected doses of 150 and 300 mg kg(-1) body weight p.o. exhibited significant dose-dependent anti-inflammatory responses, with 44.32 and 38.65% inhibition of inflammation in carrageenan-induced paw oedema and cotton pallet granuloma, respectively.
Dewanjee
Saikat
S
Department of Pharmaceutical Technology, Division of Pharmacognosy, Pharmacognosy and Phytotherapy Research Laboratory, Jadavpur University, Kolkata, India. s.dewanjee@yahoo.com
Mandal
Vivekananda
V
Sahu
Ranabir
R
Dua
Tarun K
TK
Manna
Ashis
A
Mandal
Subhash C
SC
D000328:Adult; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use; D002351:Carrageenan / Q000009:adverse effects; D004487:Edema / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control; D006099:Granuloma / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control; D006801:Humans; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy; D007963:Leukocytes, Mononuclear / Q000276:immunology; D008070:Lipopolysaccharides / Q000494:pharmacology; D024301:Plant Bark / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D028242:Theaceae / Q000737:chemistry*; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors; D055815:Young Adult; D000093242:Interleukin-6 Inhibitors
D000893:Anti-Inflammatory Agents; D002351:Carrageenan; D008070:Lipopolysaccharides; D010936:Plant Extracts; D014409:Tumor Necrosis Factor-alpha; D000093242:Interleukin-6 Inhibitors