Preliminary study of detecting urothelial malignancy with FDG PET in Taiwanese ESRD patients.
The study aimed to evaluate the possibility of applying 18F-fluorodeoxyglucose positron-emission tomography (FDG PET) for detecting primary urothelial malignancies in end-stage renal disease (ESRD) patients and the possible absence of interference by normal physiological excretory urinary radioactivity.


METHODS
Fifteen consecutive ESRD patients who had undergone preoperative FDG PET and computed tomography (CT) for their suspected urothelial malignancies from December 2002 to March 2004, were retrospectively enrolled for comparison with the postoperative histological findings.


RESULTS
The histological findings revealed 27 urothelial malignancies. The sensitivity and positive predictive value of FDG PET (CT in parentheses) were 67% (59%) and 90% (84%), respectively. A tendency was also observed towards a positive correlation between the sensitivity of FDG PET and the grade/stage of the urothelial malignancies.


CONCLUSIONS
FDG PET may serve as a feasible supplementary method for the diagnosis of urothelial malignancies in ESRD patients and a possible indicator of prognosis.
Sun
Shung-Shung
SS
Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan, R.O.C.
Chang
Chao-Hsiang
CH
Ding
Hueisch-Jy
HJ
Kao
Chia-Hung
CH
Wu
Hsi-Chin
HC
Hsieh
Te-Chun
TC
D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications*; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed; D014571:Urologic Neoplasms / Q000000981:diagnostic imaging*
D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18