title: Association between anthropometric obesity measures and coronary artery disease: a cross-sectional survey of 16,657 subjects from 444 Polish cities.
abstract: BACKGROUND
  Excessive body weight is known to cluster with cardiovascular (CV) risk factors, but it is not clear which anthropometric obesity measure provides best independent predictive value of coronary artery disease (CAD).
  
  
  RESULTS
  We explored associations between CAD and four different obesity measures (body mass index (BMI), waist circumference, waist/height and waist/height(2)) in a cohort of 16 657 subjects (40.4% men; 20.8% CAD patients), recruited by 700 primary care physicians in 444 Polish cities. 42.8% of subjects were classified as overweight, 31.7% as obese and 39.8% had abdominal obesity. In univariate analyses all obesity measures correlated with CAD (p>0.001), but waist/height(2) was the strongest discriminator between CAD patients and controls. Age-adjusted and sex-adjusted analyses confirmed a graded increase in CAD risk across distributions of all four obesity measures-1 standard deviation (SD) increase in BMI, waist, waist/height and waist/height(2) increased the odds of CAD by 1.23, 1.24, 1.26 and 1.27, respectively (all p<0.001). In models fully adjusted for CV risk factors, waist/height(2) remained the strongest obesity correlate of CAD, being the only independent associate of CAD in men. In a fully adjusted BMI-waist circumference stratified model, sarcopenic obesity (waist > median, BMI < median) and simple obesity (waist and BMI > median) were the strongest independent associates of CAD in men (p = 0.008) and women (p>0.001), respectively.
  
  
  CONCLUSIONS
  This cross-sectional study showed that waist/height(2) may potentially offer a slightly higher predictive value of CAD than BMI or waist circumference and revealed an apparent sexual dimorphism in correlations between obesity measures and CAD.
authors: Department of Cardiovascular Sciences, University of Leicester, Leicester LE3 9QP, UK.
authors: B M
authors: BM
authors: Kaess
authors: J
authors: J
authors: Jozwiak
authors: M
authors: M
authors: Mastej
authors: W
authors: W
authors: Lukas
authors: W
authors: W
authors: Grzeszczak
authors: A
authors: A
authors: Windak
authors: W
authors: W
authors: Piwowarska
authors: A
authors: A
authors: Tykarski
authors: E
authors: E
authors: Konduracka
authors: K
authors: K
authors: Rygiel
authors: A
authors: A
authors: Manasar
authors: N J
authors: NJ
authors: Samani
authors: M
authors: M
authors: Tomaszewski
mesh_terms: D000886:Anthropometry; D015992:Body Mass Index; D003324:Coronary Artery Disease / Q000453:epidemiology / Q000209:etiology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications* / Q000453:epidemiology; D011044:Poland / Q000453:epidemiology; D012307:Risk Factors