Utility of WHOQOL-BREF in measuring quality of life in sickle cell disease.
BACKGROUND
Sickle cell disease is the commonest genetic disorder in Jamaica and most likely exerts numerous effects on quality of life (QOL) of those afflicted with it. The WHOQOL-Bref, which is a commonly utilized generic measure of quality of life, has never previously been utilized in this population. We have sought to study its utility in this disease population.


METHODS
491 patients with sickle cell disease were administered the questionnaire including demographics, WHOQOL-Bref, Short Form-36 (SF-36), Flanagan's quality of life scale (QOLS) and measures of disease severity at their routine health maintenance visits to the sickle cell unit. Internal consistency reliabilities, construct validity and "known groups" validity of the WHOQOL-Bref, and its domains, were examined; and then compared to those of the other instruments.


RESULTS
All three instruments had good internal consistency, ranging from 0.70 to 0.93 for the WHOQOL-Bref (except the 'social relationships' domain), 0.86-0.93 for the SF-36 and 0.88 for the QOLS. None of the instruments showed any marked floor or ceiling effects except the SF-36 'physical health' and 'role limitations' domains. The WHOQOL-Bref scale also had moderate concurrent validity and showed strong "known groups" validity.


CONCLUSIONS
This study has shown good psychometric properties of the WHOQOL-Bref instrument in determining QOL of those with sickle cell disease. Its utility in this regard is comparable to that of the SF-36 and QOLS.
Asnani
Monika R
MR
Sickle Cell Unit, Tropical Medicine Research Institute, University of the West Indies, Mona Campus, Kingston 7, Jamaica. monika.parshadasnani@uwimona.edu.jm
Lipps
Garth E
GE
Reid
Marvin E
ME
D000293:Adolescent; D000328:Adult; D000368:Aged; D000755:Anemia, Sickle Cell; D005260:Female; D006801:Humans; D007563:Jamaica; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D011795:Surveys and Questionnaires / Q000592:standards*; D055815:Young Adult