Animal models of tuberculosis.
There is a wide range of animal models of tuberculosis; which is fortunate, given that there is a wide range of complex biological phenomena to model. Nonetheless, the inadequacy of animal models is a chronic grievance amongst researchers, often expressed in the conclusion that the mouse is not a good model of human tuberculosis. There clearly are major differences between experimental infection of mice and natural infection of humans, but this overarching dogma is inconducive to fruitful research.
Young
Douglas
D
Division of Mycobacterial Research, MRC National Institute for Medical Research, London, UK. d.young@imperial.ac.uk
D000818:Animals; D002417:Cattle; D004195:Disease Models, Animal; D006168:Guinea Pigs; D006801:Humans; D051379:Mice; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D011323:Primates; D011817:Rabbits; D051381:Rats; D014376:Tuberculosis / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D032581:Tuberculosis Vaccines / Q000276:immunology
D032581:Tuberculosis Vaccines