title: Human Brucella canis outbreak linked to infection in dogs.
abstract: The zoonotic risk of Brucella canis has been considered fairly high for persons who handle breeding dogs in kennels or are exposed to infected animals. Transmission to humans in other circumstances has been thought to be rare. We describe an uncommon outbreak of brucellosis caused by B. canis which, to the best of our knowledge, is the first reported in the literature. This outbreak involved six persons (three children and three adults), a bitch and three puppies which had close daily contact with the family. The clinical symptoms of the index case led to an erroneous diagnosis and the infection would have gone undiagnosed if culture had not been positive. This report aims to increase awareness of medical personnel of the need to order screening tests for children, immunodeficient persons or pregnant women presenting with fever of unknown origin, unexplained spleen or liver enlargement or other systemic signs. The emerging zoonotic potential of this disease in urban areas and the need to coordinate canine brucellosis surveillance systems should be evaluated.
authors: Brucellosis Service, National Laboratories and Institutes of Health Administration (ANLIS) Dr. C. G. Malbrán, Buenos Aires, Argentina. nidia@elsitio.net
authors: N E
authors: NE
authors: Lucero
authors: R
authors: R
authors: Corazza
authors: M N
authors: MN
authors: Almuzara
authors: E
authors: E
authors: Reynes
authors: G I
authors: GI
authors: Escobar
authors: E
authors: E
authors: Boeri
authors: S M
authors: SM
authors: Ayala
mesh_terms: D000328:Adult; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000907:Antibodies, Bacterial / Q000097:blood; D041002:Brucella canis / Q000276:immunology; D002006:Brucellosis / Q000382:microbiology / Q000635:transmission*; D002675:Child, Preschool; D004283:Dog Diseases / Q000382:microbiology / Q000635:transmission*; D004285:Dogs; D005190:Family; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use; D015047:Zoonoses / Q000635:transmission
chemical_list: D000900:Anti-Bacterial Agents; D000907:Antibodies, Bacterial; D015662:Trimethoprim, Sulfamethoxazole Drug Combination