Innate immune control and regulation of influenza virus infections.
Adaptive immune responses are critical for the control and clearance of influenza A virus (IAV) infection. However, in recent years, it has become increasingly apparent that innate immune cells, including natural killer cells, alveolar macrophages (aMphi), and dendritic cells (DC) are essential following IAV infection in the direct control of viral replication or in the induction and regulation of virus-specific adaptive immune responses. This review will discuss the role of these innate immune cells following IAV infection, with a particular focus on DC and their ability to induce and regulate the adaptive IAV-specific immune response.
McGill
Jodi
J
Department of Pathology and Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, Iowa 52242, USA.
Heusel
Jonathan W
JW
Legge
Kevin L
KL
D000818:Animals; D003713:Dendritic Cells / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D009980:Influenza A virus / Q000276:immunology*; D007251:Influenza, Human / Q000276:immunology*; D007694:Killer Cells, Natural / Q000276:immunology*; D016676:Macrophages, Alveolar / Q000276:immunology*; D014779:Virus Replication / Q000276:immunology