International variations in infection supportive care practices for paediatric patients with acute myeloid leukaemia.
This study described infection-related supportive care practices amongst centres participating in two large paediatric acute myeloid leukaemia (AML) cooperative groups, Children's Oncology Group (COG) and Berlin-Frankfurt-Muenster (BFM). We surveyed 216 COG and 55 BFM institutions. The overall survey response rate was 83.8%. Antibacterial prophylaxis was more common among BFM (15/46, 32.6%) compared to COG (24/180, 13.3%, P < 0.0001) institutions. Antifungal prophylaxis also was more common among BFM (42/46, 91.3%) compared to COG (137/178, 77.0%, P = 0.03). There were systematic differences in infection-related supportive care practices. This information may be used to encourage harmonization of supportive care practices and future randomized trials.
Lehrnbecher
Thomas
T
Paediatric Haematology and Oncology, University of Frankfurt, Frankfurt, Germany.
Ethier
Marie-Chantal
MC
Zaoutis
Theoklis
T
Creutzig
Ursula
U
Gamis
Alan
A
Reinhardt
Dirk
D
Aplenc
Richard
R
Sung
Lillian
L
D019072:Antibiotic Prophylaxis / Q000706:statistics & numerical data; D000935:Antifungal Agents / Q000627:therapeutic use; D001424:Bacterial Infections / Q000150:complications / Q000517:prevention & control; D004363:Drug Utilization / Q000706:statistics & numerical data; D019538:Health Care Surveys; D006801:Humans; D007391:International Cooperation; D015470:Leukemia, Myeloid, Acute / Q000150:complications*; D009181:Mycoses / Q000150:complications / Q000517:prevention & control; D009894:Opportunistic Infections / Q000150:complications* / Q000517:prevention & control*; D011364:Professional Practice / Q000706:statistics & numerical data*
D000935:Antifungal Agents