title: Changes in dynamic and kinematic properties of saccades in ocular myasthenia following intravenous immunoglobulin treatment.
abstract: The dynamics and kinematics of saccades in a patient with severe ocular myasthenia were studied before and after treatment with intravenous immunoglobulin (IVIG). Before therapy, horizontal saccades were hypometric, but faster than similar-sized saccades made by normal subjects. During a 5-minute test period, saccades decreased in size (fatigue effect), but remained faster than those of controls. Listing's plane of the eye with greater ophthalmoplegia was increased in thickness. After IVIG treatment, the range of eye movements improved, but saccades remained faster than those of controls. Also, no fatigue was observed and the thickness of Listing's plane was reduced toward the normal range. Increased peak velocity, despite progressive hypometria due to fatigue, supports the hypothesis that the pale global extraocular muscle fibers are relatively spared in myasthenia. Involvement of other extraocular muscle-fiber types leads to limited range of eye movements and an increase in the thickness of Listing's plane.
authors: The Daroff-Dell'Osso Ocular Motility Laboratory, Veterans Affairs Medical Center and Case Western Reserve University, Cleveland, Ohio, USA.
authors: Alessandro
authors: A
authors: Serra
authors: Matthew J
authors: MJ
authors: Thurtell
authors: R John
authors: RJ
authors: Leigh
mesh_terms: D001696:Biomechanical Phenomena; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000503:physiopathology / Q000628:therapy*; D012438:Saccades; D016896:Treatment Outcome
chemical_list: D016756:Immunoglobulins, Intravenous