title: Apparent diffusion coefficient and vascular signal fraction measurements with magnetic resonance imaging: feasibility in metastatic ovarian cancer at 3 Tesla: technical development.
abstract: This prospective study aims to evaluate the feasibility of DWI at 3 Tesla in patients with advanced ovarian cancer and investigate the differences in vascular signal fraction (VSF) and apparent diffusion coefficient (ADC) values between primary ovarian mass and metastatic disease. Twenty patients with suspected advanced ovarian carcinoma were enrolled in the study. High-resolution T2W FRFSE images were used to confirm the position of three marker lesions: primary ovarian mass, omental cake and peritoneal deposit. Multislice DWI was acquired in a single breath-hold using multiple b-values. The three marker lesions were outlined by an experienced radiologist on ADC and VSF maps. Ovarian lesions showed the highest ADC values. The mean ADC value for peritoneal deposits was significantly lower than for both ovarian lesions (p = 0.03) and omental cake (p = 0.03). The VSF for omental cake was significantly higher than for ovarian lesions (p = 0.01) and peritoneal deposits (p = 0.04). There was a significant positive correlation between ADC and VSF for peritoneal deposits (p = 0.04). DWI in advanced ovarian cancer is feasible at 3 T. There are significant differences in baseline ADC and VSF values between ovarian cancer, omental cake and peritoneal deposits that may explain the mixed treatment response that occurs at different disease sites.
authors: Department of Radiology, Addenbrookes Hospital and University of Cambridge, Cambridge, UK. es220@radiol.cam.ac.uk
authors: Evis
authors: E
authors: Sala
authors: Andrew N
authors: AN
authors: Priest
authors: Masako
authors: M
authors: Kataoka
authors: Martin J
authors: MJ
authors: Graves
authors: Mary A
authors: MA
authors: McLean
authors: Ilse
authors: I
authors: Joubert
authors: John R
authors: JR
authors: Griffiths
authors: Robin A F
authors: RA
authors: Crawford
authors: Mercedes
authors: M
authors: Jimenez-Linan
authors: Helena M
authors: HM
authors: Earl
authors: James D
authors: JD
authors: Brenton
authors: David J
authors: DJ
authors: Lomas
mesh_terms: D000328:Adult; D000368:Aged; D000465:Algorithms; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000556:secondary*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity