Swerilactones A and B, anti-HBV new lactones from a tradtional Chinese herb: Swertia mileensis as a treatment for viral hepatitis.
Swerilactones A (1) and B (2), two novel lactones with an unprecedented 6/6/6/6/6 pentacyclic ring system, were isolated from the traditional Chinese herb of Swertia mileensis with activity against the hepatitis virus. Their structures and relative stereochemistry were elucidated based on spectroscopic methods and further confirmed by X-ray single crystal diffraction analysis. In vitro antihepatitis B virus (HBV) assay on Hep G 2.2.15 cell line showed that compound 1 inhibited HBsAg and HBeAg secretion with IC(50) values of 3.66 and 3.58 mM, respectively.
Geng
Chang-An
CA
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PRC.
Jiang
Zhi-Yong
ZY
Ma
Yun-Bao
YB
Luo
Jie
J
Zhang
Xue-Mei
XM
Wang
Hong-Ling
HL
Shen
Yong
Y
Zuo
Ai-Xue
AX
Zhou
Jun
J
Chen
Ji-Jun
JJ
D000998:Antiviral Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D006514:Hepatitis B Surface Antigens / Q000737:chemistry; D018936:Hepatitis C Antigens / Q000737:chemistry; D007783:Lactones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D029967:Swertia / Q000737:chemistry*; D014965:X-Rays
D000998:Antiviral Agents; D004365:Drugs, Chinese Herbal; D006514:Hepatitis B Surface Antigens; D018936:Hepatitis C Antigens; D007783:Lactones; C546816:swerilactone A; C546817:swerilactone B