[Immunomodulatory effect of extracorporeal hemocorrection in patients with surgical sepsis].
The study was undertaken to evaluate the immunomodulatory effects of various methods of extracorporeal hemocorrection in septic patients. Thirty-two patients in whom the course of the underlying disease was complicated by the development of sepsis were examined. A package of therapeutic measures involved debridement of an infection focus, de-escalation antibacterial therapy, nutritional support, and immunomodulatory therapy. All the patients underwent procedures of plasma filtration and continuous venovenous hemofiltration; granulocytopheresis was carried out in 5 patients. Granulocytopheresis was shown to eliminate dead leukocytes from the bloodstream within a few hours, which contributed to clinical improvement. Plasmafiltration in patients with sepsis resulted to a reduction in the degree of a systemic inflammatory reaction, to normalization of coagulation homeostasis, which indirectly affected immunological parameters. Continuous venovenous hemofiltration made it possible to make continuous elimination of the low and average molecular-weight substances, corrected liquid balance, and well affected gas exchange in the lung.
Borovkova
N V
NV
Aleksandrova
I V
IV
Khvatov
V B
VB
Reĭ
S I
SI
Il'inskiĭ
M E
ME
Abakumov
M M
MM
D018806:APACHE; D005260:Female; D006440:Hemofiltration / Q000379:methods; D006801:Humans; D056747:Immunomodulation / Q000502:physiology*; D008297:Male; D010956:Plasmapheresis / Q000379:methods; D018805:Sepsis / Q000175:diagnosis / Q000276:immunology* / Q000401:mortality / Q000601:surgery* / Q000628:therapy; D012720:Severity of Illness Index; D016896:Treatment Outcome