title: Antibacterial compounds from mushrooms I: a lanostane-type triterpene and prenylphenol derivatives from Jahnoporus hirtus and Albatrellus flettii and their activities against Bacillus cereus and Enterococcus faecalis.
abstract: Antibacterial bioassay-guided fractionation of two American mushroom species, Jahnoporus hirtus and Albatrellus flettii, led to the isolation and identification of their major antibacterial constituents: 3,11-dioxolanosta-8,24( Z)-diene-26-oic acid (1) from J. hirtus and confluentin (2), grifolin (3), and neogrifolin (4) from A. flettii. Compound 1 is a new lanostane-type triterpene. All purified compounds were evaluated for their ability to inhibit the growth of Bacillus cereus and Enterococcus faecalis using standard MIC assays. Compounds 1- 4 demonstrated MIC values of 40, 20, 10, and 20 microg/mL, respectively, against B. cereus and MIC values of 32, 1.0, 0.5, and 0.5 microg/mL, respectively, against E. faecalis. Thus, one novel compound and three others were shown to possess antimicrobial activities against these gram-positive bacteria employed as surrogates for more virulent and dangerous pathogens.
authors: Department of Chemistry, University of Wisconsin-La Crosse, La Crosse, WI 54601, USA.
authors: Xue-Ting
authors: XT
authors: Liu
authors: Abby L
authors: AL
authors: Winkler
authors: William R
authors: WR
authors: Schwan
authors: Thomas J
authors: TJ
authors: Volk
authors: Marc A
authors: MA
authors: Rott
authors: Aaron
authors: A
authors: Monte
mesh_terms: D000363:Agaricales / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001409:Bacillus cereus / Q000187:drug effects*; D013293:Enterococcus faecalis / Q000187:drug effects*; D007810:Lanosterol / Q000031:analogs & derivatives / Q000302:isolation & purification / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D010636:Phenols / Q000302:isolation & purification* / Q000494:pharmacology; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: C549467:3,11-dioxolanosta-8,24( Z)-diene-26-oic acid; D000900:Anti-Bacterial Agents; D010636:Phenols; D014315:Triterpenes; D007810:Lanosterol; C015316:lanostenol