Overexpression of Ycg1 or Ydr520c confers resistance to cadmium in Saccharomyces cerevisiae.
We introduced a yeast open reading frame library into Saccharomyces cerevisiae strain BY4742 to search for genes whose overexpression conferred cadmium resistance to yeast, toward the goal of elucidating the mechanism of cadmium toxicity. As a result, we found that the overexpression of two newly identified genes, Ycg1 and Ydr520c, each conferred strong cadmium resistance to yeast.
Hwang
Gi-Wook
GW
Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University, Miyagi 980-8578, Japan.
Sasaki
Kanae
K
Takahashi
Tsutomu
T
Yamamoto
Reiko
R
Naganuma
Akira
A
D002104:Cadmium / Q000633:toxicity*; D018797:Cell Cycle Proteins / Q000502:physiology*; D025141:Drug Resistance, Fungal / Q000235:genetics*; D015966:Gene Expression Regulation, Fungal / Q000235:genetics*; D016366:Open Reading Frames; D017346:Protein Serine-Threonine Kinases / Q000502:physiology*; D012441:Saccharomyces cerevisiae / Q000187:drug effects* / Q000235:genetics*; D029701:Saccharomyces cerevisiae Proteins / Q000502:physiology*
D018797:Cell Cycle Proteins; D029701:Saccharomyces cerevisiae Proteins; D002104:Cadmium; D017346:Protein Serine-Threonine Kinases; C505365:Sps1 protein, S cerevisiae