B-cell lymphoblastic lymphoma in the maxilla of a child: a rare case report.
Lymphoblastic lymphoma is a malignant neoplasia that originates from B or T lymphocyte precursors and rarely occurs in the mouth. The authors report a rare case of B-cell lymphoblastic lymphoma in the maxilla of a child. Clinical examination revealed facial asymmetry with a swelling of the right maxilla, covered by healthy mucosa and painful to palpation. Radiographic examination revealed a poorly defined radiolucent lesion. Based on the hypothesis of malignant neoplasia of hematopoietic origin, an incisional biopsy was performed. Histological examination revealed malignant neoplasia with proliferation of monomorphic, lymphoid cells. Immunohistochemical staining was positive for leucocyte common antigen (LCA), CD10, CD20, CD79, and terminal deoxynucleotidyl transferase (TdT). After the diagnosis of B-cell lymphoblastic lymphoma, the patient underwent chemotherapy, but died of leukoencephalopathy and demyelinization caused by high doses of methotrexate.
Cavalcante
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AS
Department of Bioscience and Oral Diagnosis, School of Dentistry of São José dos Campos, São Paulo State University, São José dos Campos, São Paulo, Brazil. anasueli@fosjc.unesp.br
Anbinder
A L
AL
Pontes
E M
EM
Carvalho
Y R
YR
D018951:Antigens, CD20 / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D051925:CD79 Antigens / Q000032:analysis; D002648:Child; D004253:DNA Nucleotidylexotransferase / Q000032:analysis; D005146:Facial Asymmetry / Q000175:diagnosis; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D017493:Leukocyte Common Antigens / Q000032:analysis; D016393:Lymphoma, B-Cell / Q000175:diagnosis*; D008441:Maxillary Neoplasms / Q000175:diagnosis*; D015260:Neprilysin / Q000032:analysis; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis*; D011862:Radiography, Panoramic; D014057:Tomography, X-Ray Computed
D018951:Antigens, CD20; D014408:Biomarkers, Tumor; D051925:CD79 Antigens; D004253:DNA Nucleotidylexotransferase; D017493:Leukocyte Common Antigens; D015260:Neprilysin