title: When once is not enough--further evidence of procalcitonin-guided antibiotic stewardship.
abstract: Every day, critical care physicians around the world face the same challenge of the optimal timing of antimicrobial administration: when to start and when to stop antibiotics. Duration of antibiotic therapy for sepsis is mostly based on expert opinion, but its reduction is arguably the most promising approach to decrease emergence and selection of antibiotic resistance. The study by Hochreiter and colleagues presents another piece of evidence suggesting that procalcitonin may indeed be a valuable diagnostic parameter to guide antibiotic treatment duration, despite the ongoing controversy about the diagnostic accuracy of pro-calcitonin.
authors: Infection Control Program, Department of Internal Medicine, University of Geneva Hospitals and Medical School, CH-1211 Geneva 14, Switzerland. stephan.harbarth@hcuge.ch
authors: Stephan
authors: S
authors: Harbarth
authors: Werner C
authors: WC
authors: Albrich
authors: Beat
authors: B
authors: Müller
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002116:Calcitonin / Q000097:blood*; D015740:Calcitonin Gene-Related Peptide; D016638:Critical Illness; D003657:Decision Making; D004334:Drug Administration Schedule; D019317:Evidence-Based Medicine; D006801:Humans; D011498:Protein Precursors / Q000097:blood*; D018805:Sepsis / Q000188:drug therapy; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; C000606589:CALCA protein, human; D011498:Protein Precursors; D002116:Calcitonin; D015740:Calcitonin Gene-Related Peptide