Tricking melanoma to self-digest: a deal of a meal!
Melanoma cells acquire multiple genetic and epigenetic alterations that promote their metastasis and resistance to available therapies. In this issue of Cancer Cell, Soengas and colleagues reveal that the induction of endosome-mediated autophagy results in efficient melanoma cell death, thereby offering new potential means for treatment of this devastating cancer.
Kim
Hyungsoo
H
Signal Transduction Program, Burnham Institute for Medical Research, La Jolla, CA 92130, USA.
Ronai
Ze'ev
Z
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects / Q000235:genetics / Q000276:immunology; D011992:Endosomes / Q000187:drug effects / Q000235:genetics / Q000378:metabolism; D006801:Humans; D007113:Immunity, Innate; D008545:Melanoma / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D051379:Mice; D010588:Phagosomes / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D011066:Poly C / Q000494:pharmacology* / Q000627:therapeutic use; D011094:Polyethyleneimine / Q000494:pharmacology* / Q000627:therapeutic use
D000970:Antineoplastic Agents; D011066:Poly C; D011094:Polyethyleneimine