title: Three new isoflavanones from Erythrina costaricensis.
abstract: Three new isoflavanones, 5,7,3'-trihydroxy-4'-methoxy-6,5'-di(gamma, gamma-dimethylallyl)-isoflavanone (1), 5,3'-dihydroxy-4'-methoxy-5'-gamma,gamma-dimethylallyl-2'',2''-dimethylpyrano[5,6 : 6,7]isoflavanone (2) and 5,3'-dihydroxy-2'',2''-dimethylpyrano[5,6 : 6,7]-2''',2'''-dimethylpyrano[5,6 : 5,4]isoflavanone (3), along with two known isoflavonoids, cristacarpin and euchrenone b(10), were isolated from the stems of Erythrina costaricensis. Their structures were established on the basis of spectroscopic evidence. Compound 3 is a rare isoflavanone possessing two 2,2-dimethylpyran moieties. Among the new isoflavanones, compound 1 showed potent antibacterial activity against methicillin-resistant Staphylococcus aureus.
authors: Faculty of Pharmacy, Meijo University, Nagoya, Japan. hitoshi@ccmfs.meijo-u.ac.jp
authors: Hitoshi
authors: H
authors: Tanaka
authors: Hisanori
authors: H
authors: Hattori
authors: Tomoko
authors: T
authors: Oh-Uchi
authors: Masaru
authors: M
authors: Sato
authors: Magoichi
authors: M
authors: Sako
authors: Yoichi
authors: Y
authors: Tateishi
authors: Ghazala Hafeez
authors: GH
authors: Rizwani
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D004895:Erythrina / Q000737:chemistry*; D007529:Isoflavones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure
chemical_list: D000900:Anti-Bacterial Agents; D007529:Isoflavones; C065753:isoflavanone