title: Temporally anticorrelated brain networks during working memory performance reveal aberrant prefrontal and hippocampal connectivity in patients with schizophrenia.
abstract: Functional neuroimaging studies on cognitive dysfunction in schizophrenia have suggested regional brain activation changes in the dorsolateral prefrontal cortex and the medial temporal lobe. However, less is known about the functional coupling of these areas during cognitive performance. In this study, we used functional magnetic resonance imaging, a verbal working memory (WM) task and multivariate statistical techniques to investigate the functional coupling of temporally anticorrelated neural networks during cognitive processing in patients with schizophrenia (n=16) compared to healthy controls (n=16). Independent component analysis identified 18 independent components (ICs) among which two ICs were selected for further analyses. These ICs included temporally anticorrelated networks which were most highly associated with the delay period of the task in both healthy controls and patients with schizophrenia. Functional network abnormalities in patients with schizophrenia were detected within a "task-positive" lateral frontoparietal network, where increased functional connectivity was found in bilateral dorsolateral prefrontal regions. In addition, aberrant functional coupling of the hippocampal cortex in patients with schizophrenia was detected within a "task-negative" medial frontotemporal network. In patients with schizophrenia, functional connectivity indices in the left dorsolateral prefrontal cortex and the right hippocampal cortex were positively correlated with accuracy during the WM task, while the connectivity strength in the right dorsolateral prefrontal cortex was negatively correlated with measures of symptom severity. These data suggest that within two temporally anticorrelated network states, patients with schizophrenia exhibit increased and persistent dorsolateral prefrontal and hippocampal connectivity during WM performance.
authors: Department of Psychiatry and Psychotherapy III, University of Ulm, Leimgrubenweg 12-14 89075 Ulm, Germany. christian.wolf@uni-ulm.de
authors: Robert Christian
authors: RC
authors: Wolf
authors: Nenad
authors: N
authors: Vasic
authors: Fabio
authors: F
authors: Sambataro
authors: Annett
authors: A
authors: Höse
authors: Karel
authors: K
authors: Frasch
authors: Markus
authors: M
authors: Schmid
authors: Henrik
authors: H
authors: Walter
mesh_terms: D000328:Adult; D001931:Brain Mapping; D005260:Female; D006624:Hippocampus / Q000098:blood supply / Q000503:physiopathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology*; D009415:Nerve Net / Q000098:blood supply / Q000503:physiopathology; D009434:Neural Pathways / Q000098:blood supply; D009483:Neuropsychological Tests; D010100:Oxygen / Q000097:blood; D017397:Prefrontal Cortex / Q000098:blood supply / Q000503:physiopathology*; D025341:Principal Component Analysis; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000473:pathology* / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D013223:Statistics as Topic; D055815:Young Adult
chemical_list: D010100:Oxygen