Related mechanisms for end processing at telomeres and DNA double-strand breaks.
In a recent issue of Molecular Cell, Bonetti et al. (2009) identify in the yeast Saccharomyces cerevisiae that the molecular activities that generate 3' overhangs at telomeric DNA ends are the same as those that resect DNA at double-strand breaks.
Iglesias
Nahid
N
Ecole Polytechnique Fédérale de Lausanne, ISREC-Swiss Institute for Experimental Cancer Research, CH-1015 Lausanne, Switzerland.
Lingner
Joachim
J
D053903:DNA Breaks, Double-Stranded; D004260:DNA Repair / Q000502:physiology; D004271:DNA, Fungal / Q000737:chemistry / Q000235:genetics; D008957:Models, Genetic; D012441:Saccharomyces cerevisiae / Q000235:genetics* / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D016615:Telomere / Q000737:chemistry / Q000235:genetics*
D004271:DNA, Fungal; D029701:Saccharomyces cerevisiae Proteins