[Preparation and characterization of hydroxycamptothecin nanoparticles of amphiphilic block copolymer].
OBJECTIVE
To prepare hydroxycamptothecin nanoparticles of amphiphilic block copolymer and study its characterization initially.


METHODS
Polyethyleneglycol-polycaprolactone (PEG-PCL) was synthesized and its structure was characterized by 1H-NMR. The HCPT-PEG-PCL-NPs were prepared by solvent-diffusion method using PEG-PCL block copolymer as a matrix and HCPT as an antitumor agent. Then the obtained NPs were evaluated and the physical stabilities of both suspl and freeze drying powder were investigated.


RESULTS
The mean particle size of the prepared NPs was 164.5 nm, polydispersity index (PI) was 0.14, drug loading (DL) was 5.49%, entrapment efficiency (EE) was 83.2%, zeta potential was -26.1 mV. The physical stability of freeze drying powder was better and hot environment seemed to be bad for the stability.


CONCLUSIONS
The HCPT-PEG-PCL-NPs increase the solubility of HCPT in water and are valuable for the development of the novel dosage form of HCPT.
Xi
Na
N
Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. xfiona224@yahoo.com.cn
Hou
Lian-Bing
LB
D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage* / Q000737:chemistry; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D004337:Drug Carriers / Q000737:chemistry*; D004355:Drug Stability; D007783:Lactones / Q000737:chemistry; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D012995:Solubility; D013678:Technology, Pharmaceutical
D000972:Antineoplastic Agents, Phytogenic; D004337:Drug Carriers; D007783:Lactones; D011108:Polymers; D011092:Polyethylene Glycols; D002166:Camptothecin