title: Significant synergistic effect of peroxisome proliferator-activated receptor gamma C-2821T and diabetes on the risk of ischemic stroke.
abstract: OBJECTIVE
  To explore the relationship between the genetic polymorphisms of PPARgamma (Pro12Ala, C1431T, and C-2821T) and the risk of ischemic stroke and to investigate whether these genetic polymorphisms of PPARgamma would modify the risk of ischemic stroke among patients with hypertension or diabetes.
  
  
  METHODS
  The case-control study was conducted with 537 ischemic stroke patients and 537 control subjects. A structured questionnaire was used to collect information on conventional cardiovascular risk factors and laboratory results. The genetic polymorphisms of PPARgamma were determined by PCR-restriction fragment-length polymorphism.
  
  
  RESULTS
  A significant interaction was seen between the -2821C allele and diabetes but not between this allele and hypertension. A markedly elevated risk of ischemic stroke (odds ratio 9.7) was found in the subjects with diabetes and the -2821C allele compared with that in those without these two risk factors.
  
  
  CONCLUSIONS
  The -2821C allele of PPARgamma was a strong predictor of ischemic stroke for diabetic patients.
authors: School of Public Health, Taipei Medical University, Taipei, Taiwan.
authors: Fang-I
authors: FI
authors: Hsieh
authors: Wei-Cheng
authors: WC
authors: Lo
authors: Huey-Juan
authors: HJ
authors: Lin
authors: Yi-Chen
authors: YC
authors: Hsieh
authors: Li-Ming
authors: LM
authors: Lien
authors: Chyi-Huey
authors: CH
authors: Bai
authors: Hung-Pin
authors: HP
authors: Tseng
authors: Hung-Yi
authors: HY
authors: Chiou
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019943:Amino Acid Substitution; D003925:Diabetic Angiopathies / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D016017:Odds Ratio; D047495:PPAR gamma / Q000235:genetics*; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D011237:Predictive Value of Tests; D012307:Risk Factors; D020521:Stroke / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000235:genetics* / Q000473:pathology; D014057:Tomography, X-Ray Computed
chemical_list: D047495:PPAR gamma