title: Sinus histiocytosis with massive lymphadenopathy: a case report with pleural effusion and cervical lymphadenopathy.
abstract: Sinus histiocytosis with massive lymphadenopathy (SHML) is a rare disorder characterized by a nonneoplastic proliferation of distinctive histiocyte cells within lymph node sinuses and lymphatics in extranodal sites. SHML occurs worldwide and is primarily a disease of childhood and early adulthood. A 26-yr-old man presented with painless palpable lymph node in cervical area. Radiographic studies revealed pleural effusion with lymphadenopathy and calcification in mediastinum. The cervical lymph node biopsy showed dilated sinuses filled with histiocytes with clear cytoplasm. The cells stained positive with CD68 and S-100. These cytologic and immunohistochemical findings were considered consistent with the diagnosis of SHML.
authors: Department of Internal Medicine, Chonnam National University Hospital, Gwangju, Korea.
authors: Jinyung
authors: J
authors: Ju
authors: Yong Soo
authors: YS
authors: Kwon
authors: Kae Jung
authors: KJ
authors: Jo
authors: Dong Ryeol
authors: DR
authors: Chae
authors: Jung Hwan
authors: JH
authors: Lim
authors: Hee Jung
authors: HJ
authors: Ban
authors: Su Young
authors: SY
authors: Chi
authors: In Jae
authors: IJ
authors: Oh
authors: Ku Sik
authors: KS
authors: Kim
authors: Yu Il
authors: YI
authors: Kim
authors: Young Chul
authors: YC
authors: Kim
authors: Sung Chul
authors: SC
authors: Lim
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000378:metabolism; D015214:Antigens, Differentiation, Myelomonocytic / Q000378:metabolism; D006644:Histiocytes / Q000473:pathology; D015618:Histiocytosis, Sinus / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D009333:Neck; D010996:Pleural Effusion / Q000000981:diagnostic imaging*; D009418:S100 Proteins / Q000378:metabolism; D014057:Tomography, X-Ray Computed; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D009418:S100 Proteins; C067980:CD68 antigen, human; D000097382:CD68 Molecule