Panic disorder as a risk factor for post-partum depression: Results from the Perinatal Depression-Research & Screening Unit (PND-ReScU) study.
BACKGROUND
Although the role of anxiety disorders on the development of Post-partum Depression (PPD) have already been studied in literature, that of individual anxiety disorders has not received specific attention. The aim of this study is to investigate the role of Panic Disorder (PD) and family history for PD as risk factors for PPD.


METHODS
Six hundred women were recruited in a prospective, observational study at the 3rd month of pregnancy and followed up until the 6th month after delivery. At baseline, risk factors for PPD, Axis-I disorders and family history for psychiatric disorders were assessed. We investigated minor and major depression (mMD) occurred at 1st, 3rd and 6th months post-partum. Logistic regression models were used to estimate the association between PD, family history for PD and PPD.


RESULTS
Forty women had mMD in the post-partum. PD during pregnancy (RR=4.25; 95%CI:1.48-12.19), a history of PD (RR 2.47; 95%CI:1.11-5.49) and family history for PD (RR=2.1; 95%CI:1.06-4.4) predicted PPD after adjusting for lifetime depression and risk factors for PPD.


CONCLUSIONS
The response rate is moderately low, but it is similar to other studies. The drop out rate is slightly high, however the 600 women who completed the 6th month follow-up did not differ from the presence of PD at baseline.


CONCLUSIONS
PD is an independent risk factor for PPD, underscoring need to assess PD symptoms during pregnancy. Furthermore, PD represents an important risk factor for the development of PPD and should be routinely screened in order to develop specific preventive interventions.
Rambelli
C
C
Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, School of Medicine, University of Pisa, Via Roma 67, 56100 Pisa, Italy. cristinarambelli@hotmail.com
Montagnani
M S
MS
Oppo
A
A
Banti
S
S
Borri
C
C
Cortopassi
C
C
Ramacciotti
D
D
Camilleri
V
V
Mula
M
M
Cassano
G B
GB
Mauri
M
M
D000328:Adult; D019052:Depression, Postpartum / Q000175:diagnosis* / Q000453:epidemiology* / Q000235:genetics / Q000523:psychology; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics / Q000523:psychology; D005260:Female; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D007406:Interview, Psychological; D007558:Italy; D008403:Mass Screening / Q000706:statistics & numerical data*; D016584:Panic Disorder / Q000175:diagnosis* / Q000453:epidemiology* / Q000235:genetics / Q000523:psychology; D011247:Pregnancy; D011446:Prospective Studies; D012307:Risk Factors