title: [Genotype analysis of killer cell immunoglobulin-like receptors in Graves' disease patients].
abstract: OBJECTIVE
  Killer cell immunoglobulin-like receptor (KIR) can modulate the activity of NK and T lymphocyte. To investigate whether the KIR genotype possessing a susceptibility to Graves disease (GD).
  
  
  METHODS
  Using PCR-SSP to detect KIR genotype in 96 GD patients and 96 randomly selected healthy controls.
  
  
  RESULTS
  The genotype frequency of 2DS2-, 2DL2-, 2DL3+, 2DL1+, 3DL1+, 3DS1-, 2DL5-, 2DS3-, 2DS5-, 2DS1-, 2DS4- was significantly higher in the patient group compared to that of the control group (6.25% vs 0%, P<0.05). Genotype of 2DS2-, 2DL2-, 2DL3+, 2DL1+, 3DL1+, 3DS1-, 2DL5-, 2DS3-, 2DS5-, 2DS1-, 2DS4+ is the most prevalent in the controls (28.13% vs 10.42%, P<0.01). Genotypes without activating KIR genes have higher frequency in patient group.
  
  
  CONCLUSIONS
  The difference of KIR genotypes between GD patients and healthy controls may explain the pathogenesis of GD.
authors: Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, China. haiqingzhang7576@163.com
authors: Hai-qing
authors: HQ
authors: Zhang
authors: Jia-jun
authors: JJ
authors: Zhao
authors: Yue-ran
authors: YR
authors: Zhao
authors: Qing-bo
authors: QB
authors: Guan
authors: Ling
authors: L
authors: Gao
authors: Huai-dong
authors: HD
authors: Song
mesh_terms: D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006111:Graves Disease / Q000235:genetics* / Q000276:immunology; D006801:Humans; D008297:Male; D054340:Receptors, KIR / Q000235:genetics* / Q000276:immunology
chemical_list: D054340:Receptors, KIR