Solitary fibrous tumour of the central nervous system: pathological  study of eight cases and review of the literature.
OBJECTIVE
Solitary fibrous tumours (SFT) of the central nervous system are rare neoplasms that usually present as dura-based masses and clinically resemble meningiomas. Histologically, they can be similar to haemangiopericytoma or fibrous meningioma. We present herewith a pathological study of eight patients with SFT and compare our results with the published data.


METHODS
All tumours diagnosed as SFT over a period of 15 years were retrieved from the files of La Rabta Hospital Department of Pathology, Tunisia. Routine histological sections were prepared from formalin-fixed, paraffin-embedded specimens. Immunohistochemical analysis was performed using antibodies raised against vimentin, CD34, CD99, Bcl-2 and MIB-1.


RESULTS
The SFT group consisted of four males and four females with a mean age of 44 years. The tumours were supratentorial in six cases, tentorial in one case and located in the lateral right ventricle in the last case. All patients underwent surgery as initial treatment. Histologically, SFT were similar to their soft tissue counterparts. Two cases demonstrated increased cellularity, marked nuclear hyperchromasia and marked cellular pleomorphism. Only the later two cases recurred after 6 months of follow-up.


CONCLUSIONS
Little is known about the biological behaviour of SFT, although most seem amenable to total resection.
Mekni
Amina
A
Department of Pathology, Hospital La Rabta, Tunis, Tunisia. aminamekninouira@yahoo.fr
Kourda
Jihene
J
Hammouda
Karim Ben
KB
Tangour
Monia
M
Kchir
Nidhameddine
N
Zitouna
Moncef
M
Haouet
Slim
S
D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D001932:Brain Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D003937:Diagnosis, Differential; D018572:Disease-Free Survival; D004388:Dura Mater / Q000473:pathology; D005260:Female; D006393:Hemangiopericytoma / Q000175:diagnosis; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008297:Male; D008579:Meningioma / Q000175:diagnosis; D008875:Middle Aged; D016634:Radiosurgery; D054364:Solitary Fibrous Tumors / Q000737:chemistry / Q000473:pathology* / Q000601:surgery
D014408:Biomarkers, Tumor