sPhospholipase A(2) is inhibited by anthocyanidins.
Epidemiological studies suggest that nutritional antioxidants may reduce the incidence of neurodegenerative disorders and age-related cognitive decline. Specifically, protection against oxidative stress and inflammation has served as a rationale for promoting diets rich in vegetables and fruits. The present study addresses secretory phospholipase A(2) (sPLA(2)) as a novel candidate effector of neuroprotection conferred by anthocyanins and anthocyanidins. Using a photometric assay, 15 compounds were screened for their ability to inhibit PLA(2). Of these, cyanidin, malvidin, peonidin, petunidin, and delphinidin achieved K(i) values <or=18 microM, suggesting a modulatory role for berry polyphenols in phospholipid metabolism.
Dreiseitel
Andrea
A
Department of Psychiatry, University of Regensburg, Regensburg, Germany. andrea.dreiseitel@klinik.uni-regensburg.de
Korte
Gabriele
G
Schreier
Peter
P
Oehme
Anett
A
Locher
Sanja
S
Hajak
Goeran
G
Sand
Philipp G
PG
D000872:Anthocyanins / Q000737:chemistry / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D004789:Enzyme Activation / Q000187:drug effects*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D066298:In Vitro Techniques; D008956:Models, Chemical; D054467:Phospholipases A2 / Q000378:metabolism*; D010783:Photometry / Q000379:methods
D000872:Anthocyanins; D004791:Enzyme Inhibitors; D054467:Phospholipases A2