Silica xerogel-chitosan nano-hybrids for use as drug eluting bone replacement.
Silica xerogel-chitosan hybrids containing vancomycin were fabricated by the sol-gel process at room temperature and their potential as a drug eluting bone replacement was evaluated in terms of their mechanical properties and drug release behaviors. Regardless of the content of chitosan, all of the prepared hybrids had a uniform mesoporous structure, which would allow the effectual loading of vancomycin. As the content of chitosan was increased, the strength, strain to failure, and work of fracture of the hybrids were significantly enhanced, while the elastic modulus was decreased. These changes in the mechanical properties were mainly attributed to the mitigation of the brittleness of the silica xerogel through its hybridization with the flexible chitosan phase. In addition, the initial burst-effect was remarkably reduced by increasing the content of chitosan. The hybrids with more than 30% chitosan could release the vancomycin for an extended period of time in a controlled manner.
Lee
Eun-Jung
EJ
Department of Materials Science and Engineering, Seoul National University, Seoul, Republic of Korea.
Jun
Shin-Hee
SH
Kim
Hyoun-Ee
HE
Kim
Hae-Won
HW
Koh
Young-Hag
YH
Jang
Jun-Hyeog
JH
D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics; D001696:Biomechanical Phenomena; D018786:Bone Substitutes / Q000737:chemistry* / Q000378:metabolism; D048271:Chitosan / Q000032:analysis / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D019245:Compressive Strength; D054855:Drug-Eluting Stents; D008422:Materials Testing; D053758:Nanoparticles / Q000737:chemistry; D009994:Osmolar Concentration; D011208:Powders / Q000032:analysis / Q000737:chemistry / Q000494:pharmacology; D058428:Silica Gel; D012822:Silicon Dioxide / Q000737:chemistry* / Q000627:therapeutic use; D013314:Stress, Mechanical; D013718:Tensile Strength; D014640:Vancomycin / Q000493:pharmacokinetics
D000900:Anti-Bacterial Agents; D018786:Bone Substitutes; D011208:Powders; D058428:Silica Gel; D014640:Vancomycin; D012822:Silicon Dioxide; D048271:Chitosan