Microfracture technique in combination with intraarticular hyaluronic acid injection in articular cartilage defect regeneration in rabbit model.
Although articular hyaline cartilage typically has low potential for regeneration, numerous methods and techniques have been proposed to induce the reparation process. In our work, we used microfracture techniques in combination with intraarticular application of hyaluronic acid in rabbit knee articular cartilage defect. In comparison with the control group, after 6 and 10 weeks we observed a higher potential of healing in the experimental group, with thicker and more organized repair tissue filling the defect. In conclusion, a combination of the microfracture technique and application of hyaluronic acid might be potentially beneficial in inducing articular cartilage defect reparation.
Legović
Dalen
D
Orthopaedic University Hospital Lovran, Lovran, Croatia. dalen.legovic@inet.hr
Zorihić
Sanja
S
Gulan
Gordan
G
Tudor
Anton
A
Prpić
Tomislav
T
Santić
Veljko
V
Bobinac
Dragica
D
Sestan
Branko
B
Mihelić
Radovan
R
Jurdana
Hari
H
D000818:Animals; D002356:Cartilage / Q000293:injuries / Q000502:physiology / Q000601:surgery; D003131:Combined Modality Therapy; D003646:Debridement; D004195:Disease Models, Animal; D006820:Hyaluronic Acid / Q000494:pharmacology*; D007718:Knee Injuries / Q000601:surgery* / Q000628:therapy*; D008297:Male; D011817:Rabbits; D012038:Regeneration / Q000187:drug effects / Q000502:physiology; D055675:Viscosupplements / Q000494:pharmacology*; D014945:Wound Healing / Q000187:drug effects*
D055675:Viscosupplements; D006820:Hyaluronic Acid