title: Animal models of tuberculosis.
abstract: There is a wide range of animal models of tuberculosis; which is fortunate, given that there is a wide range of complex biological phenomena to model. Nonetheless, the inadequacy of animal models is a chronic grievance amongst researchers, often expressed in the conclusion that the mouse is not a good model of human tuberculosis. There clearly are major differences between experimental infection of mice and natural infection of humans, but this overarching dogma is inconducive to fruitful research.
authors: Division of Mycobacterial Research, MRC National Institute for Medical Research, London, UK. d.young@imperial.ac.uk
authors: Douglas
authors: D
authors: Young
mesh_terms: D000818:Animals; D002417:Cattle; D004195:Disease Models, Animal; D006168:Guinea Pigs; D006801:Humans; D051379:Mice; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D011323:Primates; D011817:Rabbits; D051381:Rats; D014376:Tuberculosis / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D032581:Tuberculosis Vaccines / Q000276:immunology
chemical_list: D032581:Tuberculosis Vaccines