title: Enantioselective synthesis of aspergillide B.
abstract: The enantioselective synthesis of aspergillide B, a 14-membered macrocyclic cytotoxin, was achieved in a 49% yield via 7 steps from a synthetic intermediate of aspergillide C. The spectroscopic data and specific rotation value for the synthetic material matched those of natural aspergillide B.
authors: Laboratory of Applied Bioorganic Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.
authors: Tomohiro
authors: T
authors: Nagasawa
authors: Shigefumi
authors: S
authors: Kuwahara
mesh_terms: D003603:Cytotoxins / Q000138:chemical synthesis / Q000737:chemistry; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism; D013379:Substrate Specificity
chemical_list: D003603:Cytotoxins; D018942:Macrolides; C526625:aspergillide B