title: Population pharmacokinetics of intravenous itraconazole in patients with persistent neutropenic fever.
abstract: OBJECTIVE
  Empirical use of intravenous (IV) itraconazole (ITZ) for febrile neutropenic patients has recently been introduced in Korea. This study was designed to investigate the population pharmacokinetics (PK) of IV-ITZ.
  
  
  METHODS
  Sparse PK data were collected from febrile neutropenic patients undergoing empirical ITZ therapy at 200 mg/day after loading doses. NONMEM (Version. 5.1.1) was used to estimate population PK parameters.
  
  
  RESULTS
  Forty-two patients were enrolled in the study. Mean population CL and V of IV-ITZ were 10 L/h and 1050 L, respectively. Body weight was the only contributing covariate of CL. The median simulated trough concentration of ITZ after 10 days was predicted to be about 700 ng/mL.
  
  
  CONCLUSIONS
  In this study, we explored the population PK profile of ITZ given in IV formulation. We found that the current dosage regimen of IV-ITZ (200 mg/day) was appropriate to obtain therapeutic trough concentrations for neutropenic patients in Korea.
authors: Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seocho-gu, Seoul, Korea.
authors: D-G
authors: DG
authors: Lee
authors: H
authors: H
authors: Chae
authors: Dong-Seok
authors: DS
authors: Yim
authors: S H
authors: SH
authors: Park
authors: S-M
authors: SM
authors: Choi
authors: S
authors: S
authors: Kim
authors: J-H
authors: JH
authors: Choi
authors: J-H
authors: JH
authors: Yoo
authors: W-S
authors: WS
authors: Shin
mesh_terms: D000293:Adolescent; D000328:Adult; D000935:Antifungal Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001835:Body Weight; D004305:Dose-Response Relationship, Drug; D005260:Female; D005334:Fever / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D007262:Infusions, Intravenous; D017964:Itraconazole / Q000008:administration & dosage / Q000493:pharmacokinetics*; D007723:Korea; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000188:drug therapy* / Q000209:etiology; D017711:Nonlinear Dynamics; D011446:Prospective Studies; D055815:Young Adult
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole