title: Sleep duration, lifestyle intervention, and incidence of type 2 diabetes in impaired glucose tolerance: The Finnish Diabetes Prevention Study.
abstract: OBJECTIVE
  Both short and long sleep duration have frequently been found to be associated with an increased risk for diabetes. The aim of the present exploratory analysis was to examine the association between sleep duration and type 2 diabetes after lifestyle intervention in overweight individuals with impaired glucose tolerance in a 7-year prospective follow-up.
  
  
  METHODS
  A total of 522 individuals (aged 40-64 years) were randomly allocated either to an intensive diet-exercise counseling group or to a control group. Diabetes incidence during follow-up was calculated according to sleep duration at baseline. Sleep duration was obtained for a 24-h period. Physical activity, dietary intakes, body weight, and immune mediators (C-reactive protein and interleukin-6) were measured.
  
  
  RESULTS
  Interaction between sleep duration and treatment group was statistically significant (P = 0.003). In the control group, the adjusted hazard ratios (HRs) (95% CI) for diabetes were 2.29 (1.38-3.80) and 2.74 (1.67-4.50) in the sleep duration groups 9-9.5 h and >or=10 h, respectively, compared with for that of the 7-8.5 h group. In contrast, sleep duration did not influence the incidence of diabetes in the intervention group; for sleep duration groups 9-9.5 h and >or=10 h, the adjusted HRs (95% CI) were 1.10 (0.60-2.01) and 0.73 (0.34-1.56), respectively, compared with that in the reference group (7-8.5 h sleep). Lifestyle intervention resulted in similar improvement in body weight, insulin sensitivity, and immune mediator levels regardless of sleep duration.
  
  
  CONCLUSIONS
  Long sleep duration is associated with increased type 2 diabetes risk. Lifestyle intervention with the aim of weight reduction, healthy diet, and increased physical activity may ameliorate some of this excess risk.
authors: Department of Otorhinolaryngology, Kuopio University Hospital, and University of Kuopio, Kuopio, Finland. henri.tuomilehto@kuh.fi
authors: Henri
authors: H
authors: Tuomilehto
authors: Markku
authors: M
authors: Peltonen
authors: Markku
authors: M
authors: Partinen
authors: Gilles
authors: G
authors: Lavigne
authors: Johan G
authors: JG
authors: Eriksson
authors: Christian
authors: C
authors: Herder
authors: Sirkka
authors: S
authors: Aunola
authors: Sirkka
authors: S
authors: Keinänen-Kiukaanniemi
authors: Pirjo
authors: P
authors: Ilanne-Parikka
authors: Matti
authors: M
authors: Uusitupa
authors: Jaakko
authors: J
authors: Tuomilehto
authors: Jaana
authors: J
authors: Lindström
mesh_terms: D001794:Blood Pressure; D002097:C-Reactive Protein / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology*; D004041:Dietary Fats; D004043:Dietary Fiber; D002149:Energy Intake; D005260:Female; D005387:Finland / Q000453:epidemiology; D005500:Follow-Up Studies; D018149:Glucose Intolerance / Q000150:complications / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D008019:Life Style; D008297:Male; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology; D012146:Rest / Q000502:physiology; D012307:Risk Factors; D012890:Sleep / Q000502:physiology*; D055105:Waist Circumference
chemical_list: D004041:Dietary Fats; D004043:Dietary Fiber; D002097:C-Reactive Protein