Ras and the FAK paradox.
In a recent issue of Molecular Cell, Zheng et al. (2009) describe a surprising set of findings that highlight an unexpected negative regulation of FAK by oncogenic Ras and its consequences for cancer cell migration and invasion.
Antonyak
Marc A
MA
Department of Molecular Medicine, Cornell University, Ithaca, NY 14853, USA.
Cerione
Richard A
RA
D000818:Animals; D002465:Cell Movement; D004789:Enzyme Activation; D051416:Focal Adhesion Protein-Tyrosine Kinases / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D051379:Mice; D008954:Models, Biological; D009362:Neoplasm Metastasis; D010766:Phosphorylation; D015398:Signal Transduction; D018631:ras Proteins / Q000235:genetics / Q000378:metabolism*
D051416:Focal Adhesion Protein-Tyrosine Kinases; D018631:ras Proteins