Association of leukocyte subtype counts with coronary atherosclerotic regression following pravastatin treatment.
The purpose of this study was to clarify the relation between differential leukocyte counts and inhibition of the development of coronary atherosclerosis in patients with coronary artery disease. A 6-month prospective study was conducted in 84 patients treated with pravastatin. Plaque volume, as assessed by volumetric analysis using intravascular ultrasound, decreased significantly by 12.6% (p <0.0001 vs baseline) after treatment; furthermore, a corresponding decrease of total leukocyte count (8.9%, p <0.01 vs baseline) was seen. Change in plaque volume was correlated with changes in monocyte (r = 0.35, p = 0.002) and lymphocyte (r = 0.25, p = 0.03) counts but not with changes in neutrophil, eosinophil, or basophil counts. In a multivariate regression analysis with changes in serum lipids, traditional risk factors, and medications as covariates, the decrease in monocyte count was identified as an independent predictor of coronary plaque regression (beta coefficient 0.313, 95% confidence interval 0.089 to 0.353, p = 0.0014). No correlation was found between change in monocyte count and changes in any other lipid levels. This study demonstrated that monocyte count was the only leukocyte type significantly and independently associated with coronary atherosclerotic regression, even after adjustment for changes in any lipid levels. In conclusion, the decrease in monocyte count as a nonlipid-lowering effect of statins may be used as a novel marker of coronary atherosclerotic regression.
Tani
Shigemasa
S
Department of Cardiology, Nihon University, Surugadai Hospital, Tokyo, Japan. tanishigem@yahoo.co.jp
Nagao
Ken
K
Anazawa
Takeo
T
Kawamata
Hirofumi
H
Furuya
Shingo
S
Takahashi
Hiroshi
H
Iida
Kiyoshi
K
Matsumoto
Michiaki
M
Washio
Takehiko
T
Kumabe
Narimichi
N
Hirayama
Atsushi
A
D000368:Aged; D008076:Cholesterol, HDL / Q000097:blood; D003324:Coronary Artery Disease / Q000097:blood* / Q000000981:diagnostic imaging / Q000188:drug therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009000:Monocytes; D017035:Pravastatin / Q000627:therapeutic use*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012074:Remission Induction; D016896:Treatment Outcome; D018084:Ultrasonography, Interventional
D008076:Cholesterol, HDL; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D017035:Pravastatin