title: Motor cortical epilepsia partialis continua in a patient with a localized sensory cortical lesion.
abstract: We describe a 33-year-old man with cyclosporine encephalopathy who showed continuous jerking in the left upper limb due to epilepsia partialis continua. Jerk-locked back averaging (JLA) of magnetoencephalogram disclosed a spike preceding the jerk localized at the hand motor area, whereas JLA of electroencephalogram revealed no premyoclonus spikes. The paired-pulse motor cortical transcranial magnetic stimulation revealed motor cortical hyperexcitability, while the paired-pulse somatosensory evoked potential showed no sensory cortical hyperexcitability. The brain MRI showed a high intensity lesion localized at the hand sensory area. These results suggest that the jerks were produced by discharges at the motor cortex probably disinhibited by the sensory cortical lesion.
authors: Department of Neurology, Division of Neuroscience, Graduate school of Medicine, The University of Tokyo, Tokyo, Japan. setsu-tky@umin.ac.jp
authors: Setsu
authors: S
authors: Nakatani-Enomoto
authors: Yasuo
authors: Y
authors: Terao
authors: Ritsuko
authors: R
authors: Hanajima
authors: Shunichi
authors: S
authors: Matsuda
authors: Shinya
authors: S
authors: Ohminami
authors: Satomi
authors: S
authors: Inomata-Terada
authors: Hideyuki
authors: H
authors: Matsumoto
authors: Akihiro
authors: A
authors: Yugeta
authors: Tomotaka
authors: T
authors: Yamamoto
authors: Jun
authors: J
authors: Goto
authors: Masato
authors: M
authors: Yumoto
authors: Shoji
authors: S
authors: Tsuji
authors: Yoshikazu
authors: Y
authors: Ugawa
mesh_terms: D000328:Adult; D001772:Blood Cell Count; D001927:Brain Diseases / Q000139:chemically induced / Q000473:pathology; D016572:Cyclosporine / Q000009:adverse effects; D004569:Electroencephalography; D004576:Electromyography; D017036:Epilepsia Partialis Continua / Q000473:pathology*; D005073:Evoked Potentials, Somatosensory / Q000502:physiology; D006225:Hand / Q000294:innervation; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D008279:Magnetic Resonance Imaging; D015225:Magnetoencephalography; D008297:Male; D009044:Motor Cortex / Q000473:pathology*; D013003:Somatosensory Cortex / Q000473:pathology*; D050781:Transcranial Magnetic Stimulation
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine