title: Oxygenated lignans from the fruits of Schisandra arisanensis.
abstract: An acetone extract of the fruits of the Taiwanese medicinal plant Schisandra arisanensis has yielded 11 new oxygenated lignans. Four of these, named arisantetralones A-D (1-4), possess the aryltetralone skeleton, while the other seven, named arisanschinins F-L (5-11), are polyoxygenated C(18)-dibenzocyclooctadiene lignans. Structures were determined on the basis of spectroscopic analyses, especially 2D-NMR techniques. The structure of compound 1 was confirmed by X-ray crystallographic analysis. Immunomodulatory activity of the isolated lignans was tested and evaluated.
authors: School of Pharmacy, College of Medicine, National Taiwan University, Jen-Ai Road Sec. 1, Taipei 100, Taiwan, Republic of China.
authors: Yuan-Bin
authors: YB
authors: Cheng
authors: Meng-Ting
authors: MT
authors: Chang
authors: Yi-Wen
authors: YW
authors: Lo
authors: Ching-Jen
authors: CJ
authors: Ho
authors: Yuh-Chi
authors: YC
authors: Kuo
authors: Ching-Te
authors: CT
authors: Chien
authors: Shun-Ying
authors: SY
authors: Chen
authors: Shorong-Shii
authors: SS
authors: Liou
authors: Yao-Haur
authors: YH
authors: Kuo
authors: Ya-Ching
authors: YC
authors: Shen
mesh_terms: D018360:Crystallography, X-Ray; D005638:Fruit / Q000737:chemistry; D006801:Humans; D007155:Immunologic Factors / Q000097:blood / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D017705:Lignans / Q000097:blood / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010100:Oxygen / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D032141:Schisandra / Q000737:chemistry*; D013624:Taiwan
chemical_list: D007155:Immunologic Factors; D017705:Lignans; D010100:Oxygen