title: Antimicrobial activity of stereoisomers of butane-type lignans.
abstract: The relationship between the stereochemistry and antimicrobial activity of butane-type lignans was clarified. All stereoisomers of dihydroguaiaretic acid (DGA) showed both antibacterial and antifungal activity. The (+)- and (-)-7,7'-dioxodihydroguaiaretic acid (ODGA) also showed both antibacterial and antifungal activity, while meso-ODGA did not show antibacterial activity, but showed antifungal activity. No activity of any stereoisomer of secoisolariciresinol (SECO) was apparent.
authors: Faculty of Agriculture, Ehime University, Japan.
authors: Yuya
authors: Y
authors: Kawaguchi
authors: Satoshi
authors: S
authors: Yamauchi
authors: Kenta
authors: K
authors: Masuda
authors: Hisashi
authors: H
authors: Nishiwaki
authors: Koichi
authors: K
authors: Akiyama
authors: Masafumi
authors: M
authors: Maruyama
authors: Takuya
authors: T
authors: Sugahara
authors: Taro
authors: T
authors: Kishida
authors: Yojiro
authors: Y
authors: Koba
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D002073:Butanes / Q000737:chemistry*; D005517:Foodborne Diseases / Q000382:microbiology; D005658:Fungi / Q000187:drug effects; D006139:Guaiacol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D017705:Lignans / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D010935:Plant Diseases / Q000382:microbiology; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013379:Substrate Specificity
chemical_list: D000890:Anti-Infective Agents; D002073:Butanes; D017705:Lignans; C015816:dihydroguaiaretic acid; D006139:Guaiacol; C046888:butane