Possible role of human leukocyte antigen-G molecules in human oocyte/embryo secretome.
Human leucocyte antigen-G (HLA-G) is a nonclassical HLA class I molecule observed for the first time in human cytotrophoblast. Several investigations have demonstrated the presence of soluble HLA-G in oocyte/embryo secretome. A focus on the possible role of HLA-G in oocyte/embryo context will be developed in this review. In addition, the possible use of HLA-G in assisted reproductive technology will be treated.
Rizzo
Roberta
R
Department of Experimental and Diagnostic Medicine, University of Ferrara, Ferrara, Italy. rbr@unife.it
Stignani
Marina
M
Melchiorri
Loredana
L
Baricordi
Olavio R
OR
D004622:Embryo, Mammalian / Q000276:immunology / Q000378:metabolism*; D005260:Female; D015571:Follicular Fluid / Q000276:immunology / Q000378:metabolism*; D006680:HLA Antigens / Q000276:immunology / Q000378:metabolism*; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D033261:Maternal-Fetal Relations; D009865:Oocytes / Q000276:immunology / Q000378:metabolism*; D011971:Receptors, Immunologic / Q000276:immunology / Q000378:metabolism*; D054346:Receptors, KIR2DL5
D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I; D011971:Receptors, Immunologic; D054346:Receptors, KIR2DL5