Sclerosing sweat duct-like carcinoma of the tongue-a case report and a review of the literature.
In this article, we present the second case of a tongue carcinoma with distinct morphological similarities to a primary sclerosing sweat duct carcinoma of the skin. The tumor infiltrated deeply into the striated muscle and exhibited extensive peri- and intraneural growth. Neoplastic cells had mildly pleomorphic nuclei and displayed in addition to small cysts, distinct duct formation with a bilayered epithelium. Mitotic figures were scarce. Despite extensive sampling, no precursor lesion-dysplasia-was found. The immunochemical study showed positive reaction for carcinoembryonic antigen, epithelial membrane antigen, cytokeratin (CK)7, low-molecular weight CK, BerEp4, high-molecular weight CK, CK5, and CK18. p63 was positive in the peripheral parts of the neoplastic ducts with negative reaction in the luminal cells.
Petersson
Fredrik
F
Department of Pathology, National University Health System, Singapore. fredrikpetersson@live.se
Skogvall
Ingela
I
Elmberger
Göran
G
D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D002277:Carcinoma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D013544:Sweat Gland Neoplasms / Q000473:pathology; D014062:Tongue Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery
D014408:Biomarkers, Tumor