title: Hydrogen therapy may be an effective and specific novel treatment for acute radiation syndrome.
abstract: Hydrogen is the most abundant chemical element in the universe, however, it is seldom regarded as a therapeutic gas. Recent studies show that inhaled hydrogen gas (H(2)) has antioxidant and antiapoptotic activities that protect the brain against ischemia-reperfusion injury and stroke by selectively reducing hydroxyl and peroxynitrite radicals. It is also well known that more than a half of the ionizing radiation-induced cellular damage is caused by hydroxyl radicals. Studies have show that reducing hydroxyl radicals can significantly improve the protection of cells from radiation damage. In like manner, we hypothesize that hydrogen therapy may be an effective, specific and unique treatment for acute radiation syndrome.
authors: Department of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University, Xiangyin Road, 200433 Shanghai, PR China.
authors: Cong
authors: C
authors: Liu
authors: Jianguo
authors: J
authors: Cui
authors: Quan
authors: Q
authors: Sun
authors: Jianming
authors: J
authors: Cai
mesh_terms: D054508:Acute Radiation Syndrome / Q000628:therapy*; D000975:Antioxidants / Q000494:pharmacology; D017209:Apoptosis; D005609:Free Radicals; D005740:Gases; D006801:Humans; D006859:Hydrogen / Q000627:therapeutic use*; D017665:Hydroxyl Radical; D008962:Models, Theoretical; D018384:Oxidative Stress; D030421:Peroxynitrous Acid; D011835:Radiation Protection / Q000379:methods*; D015427:Reperfusion Injury; D012306:Risk
chemical_list: D000975:Antioxidants; D005609:Free Radicals; D005740:Gases; D030421:Peroxynitrous Acid; D017665:Hydroxyl Radical; D006859:Hydrogen