Impaired glucose metabolism in women with polycystic ovary syndrome.
BACKGROUND
To compare the prevalence of impaired glucose tolerance (IGT) and type 2 diabetes mellitus (T2DM) in lean and overweight/obese women with polycystic ovary syndrome (PCOS), with the data from a normal population sample.


METHODS
PCOS-affected women fulfilling ESHRE diagnostic criteria underwent an oral glucose tolerance test. Prevalence of IGT and T2DM in control sample of white healthy females was extracted from the published data from NHANES II.


RESULTS
In 225 women with PCOS, IGT was present in 6/104 (5.8%) lean and in 15/121 (12.4%) overweight/obese women. T2DM was present in 1/104 (1.0%) lean and in 3/121 (2.5%) overweight/obese PCOS women. In a sample of 643 women from NHANES II, the crude rate of IGT was 5.9%. IGT was significantly more common only in the overweight/obese PCOS subgroup as compared to the NHANES II cohort (chi(2) = 5.99, p < 0.01).


CONCLUSIONS
IGT was found significantly more frequently only in overweight/obese PCOS subjects in comparison with healthy controls.
Vrbikova
Jana
J
Institute of Endocrinology, General Faculty Hospital, Charles University, Prague, Czech Republic. jvrbikova@endo.cz
Fanta
Michal
M
Cibula
David
D
Vondra
Karel
K
Bendlova
Bela
B
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000453:epidemiology; D005260:Female; D018149:Glucose Intolerance / Q000097:blood*; D005951:Glucose Tolerance Test; D006801:Humans; D009765:Obesity / Q000097:blood; D011085:Polycystic Ovary Syndrome / Q000097:blood*; D015995:Prevalence; D012189:Retrospective Studies; D055815:Young Adult
D001786:Blood Glucose