title: Enhanced topical delivery of terbinafine hydrochloride with chitosan hydrogels.
abstract: Chitosan-based carriers have important potential applications for the administration of drugs. In the present study, topical gel formulations of terbinafine hydrochloride (T-HCl) were prepared using different types of chitosan at different molecular weight, and the antifungal inhibitory activity was evaluated to suggest an effective formulation for the treatment of fungal infections. The characteristics of gel formulations were determined with viscosity measurements and texture profile analysis. Stability studies were performed at different temperatures during 3 months. The ex vivo permeation properties were studied through rat skin by using Franz diffusion cells. The antifungal inhibitory activity of formulations on Candida species and filamentous fungi was also examined with agar-cup method. The microbiological assay was found suitable for determination of in vitro antifungal activity of T-HCl. A marketed product was used to compare the results. The antifungal activity of T-HCl significantly increased when it was introduced into the chitosan gels. A higher drug release and the highest zone of inhibition were obtained from gels prepared with the lowest molecular weight chitosan (Protasan UP CL 213) compared to that of other chitosan gels and marketed product. These results indicated the advantages of the suggested formulations for topical antifungal therapy against Candida species and filamentous fungi.
authors: Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Ege, 35100 Bornova, Izmir, Turkey. ipek.ozcan@ege.edu.tr
authors: Ipek
authors: I
authors: Ozcan
authors: Ozlem
authors: O
authors: Abaci
authors: Alev Haliki
authors: AH
authors: Uztan
authors: Buket
authors: B
authors: Aksu
authors: Hayal
authors: H
authors: Boyacioğlu
authors: Tamer
authors: T
authors: Güneri
authors: Ozgen
authors: O
authors: Ozer
mesh_terms: D000287:Administration, Topical; D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D001230:Aspergillus / Q000187:drug effects; D002175:Candida / Q000187:drug effects; D002626:Chemistry, Pharmaceutical; D048271:Chitosan; D016503:Drug Delivery Systems; D004355:Drug Stability; D006244:Hardness; D020100:Hydrogels; D066298:In Vitro Techniques; D008826:Microbial Sensitivity Tests; D009281:Naphthalenes / Q000008:administration & dosage* / Q000493:pharmacokinetics; D051381:Rats; D017208:Rats, Wistar; D012869:Skin Absorption / Q000502:physiology; D000077291:Terbinafine; D014783:Viscosity
chemical_list: D000935:Antifungal Agents; D020100:Hydrogels; D009281:Naphthalenes; D048271:Chitosan; D000077291:Terbinafine