title: Mammalian prenatal development: the influence of maternally derived molecules.
abstract: Normal fetal development is dependent upon an intricate exchange between mother and embryo. Several maternal and embryonic elements can influence this intimate interaction, including genetic, environmental or epigenetic factors, and have a significant impact on embryo development. The interaction of the genetic program of both mother and embryo, within the uterine environment, can shape the development of an individual. Accumulating data from animal models indicate that prenatal events may well initiate long-term changes in the expression of the embryo genetic program, which persist, or may only become apparent, much later in the individual's life. Also, environmental conditions during prenatal development may prompt the adoption of different developmental pathways, leading to alternative life histories. This review focuses on environmental factors, specifically maternally derived molecules, to illustrate how they can influence in utero embryonic development and, by extension, adult life.
authors: LGN CNRS UMR 7091, Université Pierre et Marie Curie, Hôpital Pitié Salpêtrière, Paris, France.
authors: Cécile
authors: C
authors: Fligny
authors: Sarah
authors: S
authors: Hatia
authors: Pascal
authors: P
authors: Amireault
authors: Jacques
authors: J
authors: Mallet
authors: Francine
authors: F
authors: Côté
mesh_terms: D000818:Animals; D047109:Fetal Development; D006801:Humans; D008322:Mammals / Q000196:embryology / Q000378:metabolism*; D009035:Mothers; D012701:Serotonin / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D012701:Serotonin