Chromosome cohesion and the spindle checkpoint.
Accurate chromosome segregation constitutes the basis of inheritance. Mistakes in chromosome segregation during mitosis lead to aneuploidy, a common feature of tumors. The accuracy of chromosome segregation is governed by a complex network of processes which ensure that each daughter cell receives the correct number of chromosomes. Herein we review recent developments in the understanding of chromosome segregation, focusing on the cohesion that holds the sister chromatids together and the spindle checkpoint which regulates anaphase onset.
Díaz-Martínez
Laura A
LA
UT-Southwestern Medical Center, Department of Pharmacology, Dallas, TX 75390, USA. Laura.Diaz-Martinez@utsouthwestern.edu
Clarke
Duncan J
DJ
D000705:Anaphase; D002135:Calcium-Binding Proteins / Q000378:metabolism; D064199:Cdc20 Proteins; D018797:Cell Cycle Proteins / Q000378:metabolism; D002868:Chromosomal Proteins, Non-Histone / Q000378:metabolism; D020090:Chromosome Segregation; D006801:Humans; D064246:Mad2 Proteins; D008938:Mitosis; D012097:Repressor Proteins / Q000378:metabolism; D000097722:Cohesins
D002135:Calcium-Binding Proteins; D064199:Cdc20 Proteins; D018797:Cell Cycle Proteins; D002868:Chromosomal Proteins, Non-Histone; D064246:Mad2 Proteins; D012097:Repressor Proteins; D000097722:Cohesins; C577697:MAD2L1 protein, human; C577488:CDC20 protein, human