Stretch growth of integrated axon tracts: extremes and exploitations.
Although virtually ignored in the literature until recently, the process of 'stretch growth of integrated axon tracts' is perhaps the most remarkable axon growth mechanism of all. This process can extend axons at seemingly impossible rates without the aid of chemical cues or even growth cones. As animals grow, the organization and extremely rapid expansion of the nervous system appears to be directed purely by mechanical forces on axon tracts. This review provides the first glimpse of the astonishing features of axon tracts undergoing stretch growth and how this natural process can be exploited to facilitate repair of the damaged nervous system.
Smith
Douglas H
DH
Center for Brain Injury and Repair, University of Pennsylvania School of Medicine, 105 Hayden Hall, 3320 Smith Walk, Philadelphia, PA 19104, USA. smithdou@mail.med.upenn.edu
D000818:Animals; D001369:Axons / Q000502:physiology*; D020439:Growth Cones / Q000502:physiology; D009416:Nerve Regeneration / Q000502:physiology*; D009422:Nervous System Diseases / Q000473:pathology / Q000503:physiopathology*; D009474:Neurons / Q000166:cytology* / Q000502:physiology; D013314:Stress, Mechanical