[GST polymorphism and cytogenetic changes in lung tissues of lung cancer patients].
Carriers of GSTTI gene deletion were found to be more subjected to a risk of emerging non-small-cell lung cancer (NSLC) than those of normal GSTT1(+) genotype. Study on the relation between GST gene polymorphism and cytogenetic indices in lung cancer patients has shown a significant excess of the group average level in cells with micronuclei in NSLC patients with GSTTI(-). The frequency of cells with micronuclei was higher in smoking patients with a mutant genotype than in smoking carriers of the GSTT1(+) genotype.
Chakova
N N
NN
Mikhalenko
E P
EP
Polonetskaia
S N
SN
Chebotareva
N V
NV
Demidchik
Iu E
IuE
Zhilko
A A
AA
Kvitko
O V
OV
Krupnova
E V
EV
D002289:Carcinoma, Non-Small-Cell Lung / Q000201:enzymology / Q000209:etiology / Q000235:genetics* / Q000473:pathology; D020732:Cytogenetic Analysis; D004247:DNA / Q000235:genetics; D017353:Gene Deletion; D020022:Genetic Predisposition to Disease; D005982:Glutathione Transferase / Q000235:genetics*; D006720:Homozygote; D006801:Humans; D008168:Lung / Q000201:enzymology / Q000473:pathology; D008175:Lung Neoplasms / Q000201:enzymology / Q000209:etiology / Q000235:genetics* / Q000473:pathology; D048629:Micronuclei, Chromosome-Defective; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012306:Risk; D012907:Smoking / Q000009:adverse effects
D004247:DNA; D005982:Glutathione Transferase; C413545:glutathione S-transferase T1