title: Complexation of biologically active aromatic compounds with DNA in the presence of theophylline.
abstract: (1)H NMR measurements (500 MHz) have been used to determine the equilibrium hetero-association constants of theophylline (THP) with various biologically active aromatic compounds (daunomycin, novantrone, ethidium bromide, proflavine, norfloxacin) and the complexation constants of THP with both single- and double-stranded oligonucleotides in solution. The results provide a quantitative estimation of the effect of THP on the binding of aromatic ligands with DNA, and a determination of the fraction of aromatic ligand removed from DNA on addition of THP.
authors: Faculty of Chemical Sciences, Autonomous University of Puebla, Puebla, Mexico.
authors: A A
authors: AA
authors: Hernandez Santiago
authors: D D
authors: DD
authors: Andrejuk
authors: A M
authors: AM
authors: Cervantes Tavera
authors: D B
authors: DB
authors: Davies
authors: M P
authors: MP
authors: Evstigneev