The relationship between microalbuminuria and the presence and extent of coronary atherosclerosis.
OBJECTIVE
To evaluate the relationship between microalbuminuria (MA) and the presence and extent of coronary artery disease (CAD).


METHODS
Four hundred and two consecutive patients were divided into 4 groups based on the presence of diabetes mellitus (DM) and MA: DM(+)/MA(+), DM(+)/MA(-), DM(-)/MA(+), and DM(-)/MA(-). Severity of CAD was assessed by the Gensini scoring system.


RESULTS
The Gensini score was 57 +/- 38.2 vs 16.5 +/- 19.5 (P < .001) in the DM(+)/MA(+) and DM(+)/MA(-) groups and 45 +/- 39.8 vs 9.9 +/- 16.6 (P < .001) in the DM(-)/MA(+) and DM(-)/MA(-) groups. Spearman correlation analysis demonstrated a positive relation between urine albumin/creatinine ratio (ACR) and extent of CAD both in the diabetic and nondiabetic patients (r = .584, P = .001; r = .545, P = .001). Microalbuminuria was found to be an independent predictor for the presence (OR for MA: 3.728; 95% CI, 1.931-7.196; P < .001) and severity of CAD (P < .001, beta = .563).


CONCLUSIONS
A strong relationship between MA and the severity of CAD was reported.
Deveci
Onur Sinan
OS
Department of Cardiology, Hacettepe University Faculty of Medicine, Ankara, Turkey. onurdeveci@yahoo.co.uk
Kabakci
Giray
G
Tulumen
Erol
E
Okutucu
Sercan
S
Aksoy
Hakan
H
Kaya
Ergun Baris
EB
Canpolat
Ugur
U
Aytemir
Kudret
K
Tokgozoglu
Lale
L
Oto
Ali
A
D000368:Aged; D000419:Albuminuria / Q000453:epidemiology*; D015897:Comorbidity; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000453:epidemiology* / Q000652:urine; D003925:Diabetic Angiopathies / Q000453:epidemiology / Q000652:urine; D003928:Diabetic Nephropathies / Q000453:epidemiology / Q000652:urine; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged