title: Enhancement of the bias component of downbeat nystagmus after lesions of the nodulus and uvula.
abstract: In two monkeys, we recorded spontaneous eye movements before and after ablation of the cerebellar nodulus and uvula (Nod/Uv). In both monkeys, there was an increase in upward ocular drift (downbeat nystagmus [DBN]) in darkness (M1: 1.5 degrees/s pre, 3.4 degrees/s post; M2: 1.3 degrees/s pre, 7.0 degrees/s post), but not in light. There was little effect of orbital position on drift velocity. These findings suggest that the Nod/Uv may play a role in the bias component of DBN.
authors: Department of Neurology, Case Western Reserve University, Cleveland VA Medical Center, Cleveland, Ohio, USA. mark.walker@case.edu
authors: Mark F
authors: MF
authors: Walker
authors: Jing
authors: J
authors: Tian
authors: Xiaoyan
authors: X
authors: Shan
authors: Howard
authors: H
authors: Ying
authors: Rafael J
authors: RJ
authors: Tamargo
authors: David S
authors: DS
authors: Zee
mesh_terms: D000818:Animals; D008253:Macaca mulatta; D009759:Nystagmus, Pathologic / Q000503:physiopathology*; D014609:Uvula / Q000473:pathology*