Families of H/ACA ncRNA molecules in trypanosomatids.
H/ACA molecules are small nucleolar RNAs (snoRNAs) that guide the conversion of a uridine into a pseudouridine. This modification is crucial for ribosomal RNA (rRNA) function. In addition, H/ACA RNA also function in ribosomal RNA processing. Unlike the double hairpin structure of H/ACA molecules in other organisms, H/ACA molecules in Trypanosomes have a single hairpin structure. Here we describe the repertoire of the 46 published H/ACA molecules in Trypanosoma brucei, as well as identify the orthologous counterparts in other Trypanosomatids enlarging the H/ACA collection in this family to over 300.
Doniger
Tirza
T
The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat-Gan, Israel.
Michaeli
Shulamit
S
Unger
Ron
R
D000818:Animals; D001483:Base Sequence; D017124:Conserved Sequence; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D016053:RNA, Protozoan / Q000737:chemistry / Q000235:genetics*; D020537:RNA, Small Nucleolar / Q000737:chemistry / Q000145:classification / Q000235:genetics*; D022661:RNA, Untranslated / Q000737:chemistry / Q000235:genetics*; D016415:Sequence Alignment; D014345:Trypanosoma / Q000235:genetics*
D016053:RNA, Protozoan; D020537:RNA, Small Nucleolar; D022661:RNA, Untranslated