title: A New Method for Radiosynthesis of C-Labeled Carbamate Groups and its Application for a Highly Efficient Synthesis of the Kappa-Opioid Receptor Tracer [C]GR103545.
abstract: (11)C-labeled carbamates can be obtained in a three-component coupling reaction of primary or secondary amines with CO(2) and (11)C-methylation reagents. [(11)C]Methyl-triflate mediated methylation of carbamino adducts provides the corresponding (11)C-labeled carbamate groups in excellent yields under mild conditions (temperatures </= 40 degrees C, 2 min reaction time). The utility of the method has been demonstrated by a highly efficient radiosynthesis of [(11)C]GR103545.
authors: Department of Chemistry, University of Oslo, Norway.
authors: B W
authors: BW
authors: Schoultz
authors: E
authors: E
authors: Arstad
authors: J
authors: J
authors: Marton
authors: F
authors: F
authors: Willoch
authors: A
authors: A
authors: Drzezga
authors: H-J
authors: HJ
authors: Wester
authors: G
authors: G
authors: Henriksen