[The use of simvastatin in patients with hypertensive intracerebral hemorrhages].
Twenty-three patients with hypertensive intracerebral hemorrhage, aged from 41 to 72 years, have been examined. The mean volume of hemotoma was 18,8+/-3,1 cm3. Patients of the control group (n=12) received standard treatment. The index group of patients (n=11) received additionally 20 mg of simvastatin daily for 30 days. Levels of cholesterol, low-density lipoprotein, number of venous circulating endothelial cells were measured in the peripheral blood. Outcomes were assessed using the modified Rankin scale. Patients with hypertensive intracerebral hemorrhage had disturbances of lipid metabolism and signs of endothelial dysfunction which manifested itself in the reduction of endothelium-dependent vasolidation and increase of circulating endothelial cell number. The study showed that the use of simvastatin normalized the lipid blood spectrum, improved the endothelial function and decreased unfavorable outcomes by 22%.
Agmazov
M K
MK
Ivanova
N E
NE
Belinskaia
V G
VG
Toshpulatov
Sh P
ShP
Arzikulov
T N
TN
D000328:Adult; D000368:Aged; D001916:Brachial Artery / Q000000981:diagnostic imaging / Q000187:drug effects / Q000503:physiopathology; D002784:Cholesterol / Q000097:blood*; D004305:Dose-Response Relationship, Drug; D004730:Endothelium, Vascular / Q000187:drug effects / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage*; D020299:Intracranial Hemorrhage, Hypertensive / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D019821:Simvastatin / Q000008:administration & dosage*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D018615:Ultrasonography, Doppler, Color; D014664:Vasodilation / Q000187:drug effects
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D002784:Cholesterol; D019821:Simvastatin