Functional polymers for targeted delivery of nucleic acid drugs.
Cationic polymers have been chemically modified with a variety of targeting molecules such as peptides, proteins, antibodies, sugars and vitamins for targeted delivery of nucleic acid drugs to specific cells. Stimuli-sensitive polymers exhibiting different size, charge and conformation in response to physiological signals from specific cells have also been utilized for targeted delivery. To achieve target-specific delivery of nucleic acids, conjugation chemistry is critical to produce stable nanosized polyplexes tethered with cell-recognizable ligands for facile cellular uptake via a receptor-mediated endocytic pathway. In this review, synthetic strategies of functional cationic polymers with various targeting ligands are presented.
Mok
Hyejung
H
Department of Biological Sciences and the Graduate Program of Nanoscience and Technology, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.
Park
Tae Gwan
TG
D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods*; D009696:Nucleic Acids / Q000008:administration & dosage*; D011108:Polymers / Q000627:therapeutic use*
D004337:Drug Carriers; D009696:Nucleic Acids; D011108:Polymers