New insights into Chlamydia intracellular survival mechanisms.
Chlamydia sp. are responsible for a wide range of diseases of significant clinical and public health importance. In this review, we highlight how recent cellular and functional genomic approaches have significantly increased our knowledge of the pathogenic mechanisms used by these genetically intractable bacteria. As the extensive repertoire of chlamydial proteins that are translocated into the mammalian host is identified and characterized, a molecular understanding of how Chlamydiae co-opt host cellular functions and block innate immune pathways is beginning to emerge.
Cocchiaro
Jordan L
JL
Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, USA.
Valdivia
Raphael H
RH
D001426:Bacterial Proteins / Q000502:physiology; D002689:Chlamydia / Q000276:immunology / Q000472:pathogenicity* / Q000502:physiology*; D003593:Cytoplasm / Q000382:microbiology*; D054884:Host-Pathogen Interactions; D006801:Humans; D007155:Immunologic Factors / Q000502:physiology; D050296:Microbial Viability; D008954:Models, Biological; D037521:Virulence Factors / Q000502:physiology
D001426:Bacterial Proteins; D007155:Immunologic Factors; D037521:Virulence Factors