Thymectomy in early childhood: a model for premature T cell immunosenescence?
The thymus is the main source of recent thymic emigrants (RTE) and naïve T cells. The aging of the immune system (immunosenescence) is characterized by loss of thymic function, decreased numbers of RTE, peripheral proliferation of mature T cells, and oligoclonal expansions of specific T cell subpopulations. As shown in several studies, thymectomized patients demonstrate signs of premature immunosenescence reminiscent of aged people, such as decreased proportions of naïve T cells and RTE, a compensatory increase of mature T cell subpopulations with increased proliferation rates, restriction of the T cell receptor repertoire, and a delayed response to new antigens and vaccinations. This review demonstrates that, despite some limitations, childhood thymectomy may serve as an useful model for premature immunosenescence, mimicking changes expected after physiological thymus involution in the elderly. Thus, it may prove an insightful tool for obtaining better understanding of human naïve T cell development, thymic function, and maintenance of the naïve T cell pool.
Zlamy
Manuela
M
Department of Pediatrics, Pediatrics I, Medical University Innsbruck, Austria.
Prelog
Martina
M
D016922:Cellular Senescence / Q000276:immunology*; D002648:Child; D006801:Humans; D015851:Interleukin-7 / Q000276:immunology; D018448:Models, Immunological; D013601:T-Lymphocytes / Q000166:cytology* / Q000276:immunology*; D013934:Thymectomy
D015851:Interleukin-7