title: CT angiography source images predict final infarct extent in patients with basilar artery occlusion.
abstract: OBJECTIVE
  The posterior circulation Acute Stroke Prognosis Early CT Score (pc-ASPECTS) is a 10-point grading system to quantify ischemic changes in the posterior circulation. We analyzed whether pc-ASPECTS on CT angiography (CTA) source images (CTASI) predicted the final infarct extent and hemorrhagic transformation (HT) rate in patients with basilar artery occlusion.
  
  
  METHODS
  A pc-ASPECTS score of 10 indicates absence of visible ischemic changes in the posterior circulation, and pc-ASPECTS score of 0 indicates ischemic changes in the midbrain, pons, and bilateral thalami, posterior circulation territories, and cerebellar hemispheres. We retrospectively studied patients with basilar artery occlusion on CTA within 24 hours from symptom onset. We applied pc-ASPECTS to noncontrast CT (NCCT), CTASI, and follow-up images by 3-reader-consensus and assessed HT on follow-up images. We calculated Spearman correlation coefficients and performed linear regression analysis. Final infarct extent and HT rates were compared across dichotomized CTASI pc-ASPECTS groups (>/= 8 vs < 8).
  
  
  RESULTS
  Among 43 patients, median (range) onset to CTA time was 5.0 hours (range, 0.7-24 hours). Pc-ASPECTS on CTASI (r = 0.75; P < .001) but not NCCT (r = 0.29; P = .063) correlated with pc-ASPECTS on follow-up scans. Linear regression demonstrated a significant positive relationship between pc-ASPECTS on CTASI and follow-up scans (R(2) = 0.58; P < 01). Median follow-up pc-ASPECTS was lower in patients with a CTASI pc-ASPECTS < 8 compared with patients with a CTASI pc-ASPECTS of 8 or more, respectively (P < .001). HT rates were 27.3% vs 9.5%, respectively (P = .24). None of 8 patients without thrombolysis had HT on follow-up scans.
  
  
  CONCLUSIONS
  The extent of hypoattenuation on CTASI predicts the final infarct extent in patients with basilar artery occlusion.
authors: Department of Neurology and Neuroradiology, Dresden University Stroke Center, University of Technology Dresden, Dresden, Germany. volker.puetz@neuro.med.tu-dresden.de
authors: V
authors: V
authors: Puetz
authors: P N
authors: PN
authors: Sylaja
authors: M D
authors: MD
authors: Hill
authors: S B
authors: SB
authors: Coutts
authors: I
authors: I
authors: Dzialowski
authors: U
authors: U
authors: Becker
authors: G
authors: G
authors: Gahn
authors: R
authors: R
authors: von Kummer
authors: A M
authors: AM
authors: Demchuk
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002533:Cerebral Angiography / Q000379:methods*; D002544:Cerebral Infarction / Q000000981:diagnostic imaging* / Q000628:therapy; D004621:Embolization, Therapeutic; D005260:Female; D006801:Humans; D008297:Male; D008636:Mesencephalon / Q000098:blood supply / Q000473:pathology; D008875:Middle Aged; D011149:Pons / Q000098:blood supply / Q000473:pathology; D011237:Predictive Value of Tests; D011379:Prognosis; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D013788:Thalamus / Q000098:blood supply / Q000473:pathology; D014057:Tomography, X-Ray Computed / Q000379:methods*; D014715:Vertebrobasilar Insufficiency / Q000000981:diagnostic imaging* / Q000628:therapy