title: Translocation-related sarcomas.
abstract: Sarcomas with chromosomal translocations represent only about one fourth of sarcoma diagnoses. However, like gastrointestinal stromal tumor (GIST), with its characteristic KIT or PDGFRA mutations, they are particularly interesting since they provide specific biological insights and mechanisms of action that may have an impact upon prognosis or therapy. These are mechanisms we are just beginning to exploit. In this section we will review the biology and clinical impact of translocation-associated sarcomas and review the clinical findings that have made a recent impact upon patients with these diverse diagnoses.
authors: Department of Clinical Genetics, Lund University Hospital, Lund, Sweden.
authors: Fredrik
authors: F
authors: Mertens
authors: Cristina R
authors: CR
authors: Antonescu
authors: Peter
authors: P
authors: Hohenberger
authors: Marc
authors: M
authors: Ladanyi
authors: Piergiorgio
authors: P
authors: Modena
authors: Maurizio
authors: M
authors: D'Incalci
authors: Paolo G
authors: PG
authors: Casali
authors: Massimo
authors: M
authors: Aglietta
authors: Thor
authors: T
authors: Alvegård
mesh_terms: D006801:Humans; D018242:Neuroectodermal Tumors, Primitive / Q000235:genetics / Q000628:therapy; D012509:Sarcoma / Q000235:genetics* / Q000628:therapy; D012512:Sarcoma, Ewing / Q000235:genetics / Q000628:therapy; D014178:Translocation, Genetic