Chromosome instability in a patient with recurrent abortions.
Chromosomal aberrations are one of the recognized possible etiologic genetic causes of recurrent spontaneous abortions. Increased chromosome instability without constitutional chromosome abnormalities is uncommon in these couples. In this work we present a non consanguineous healthy couple with recurrent abortions without constitutional chromosome aberrations in which spontaneous and induced chromosome aberrations were observed in the female. Chromosome analysis was performed in the presence of different chromosome damage inductors such as gamma radiation, Uv light, and mitomycin-C. Alterations observed only in the female were: spontaneous and induced tetraradial chromosomes and increased chromosomal damage induced only by gamma radiation. Oral mucosa micronuclei were moderately increased in the female. Chromosome instability associated to abortion is proposed.
Bobadilla-Morales
L
L
Laboratorio de Citogenética Genotoxicidad y Biomonitoreo y Clínica de Asesoramiento Genético, Instituto de Genética Humana Dr. Enrique Corona Rivera, Departamento de Biología Molecular y Genómica, División de Disciplinas Básicas, Centro Universitario Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, México. lucinabo@cucs.udg.mx
Cervantes-Luna
M I
MI
García-Cobián
T A
TA
Gómez-Meda
B C
BC
de la Torre
C Ortega
CO
Corona-Rivera
J R
JR
Corona-Rivera
A
A
D000026:Abortion, Habitual / Q000235:genetics*; D000328:Adult; D043171:Chromosomal Instability / Q000235:genetics*; D002869:Chromosome Aberrations; D004249:DNA Damage; D004252:DNA Mutational Analysis; D005260:Female; D005720:Gamma Rays; D006801:Humans; D048629:Micronuclei, Chromosome-Defective / Q000528:radiation effects; D015162:Micronucleus Tests; D011247:Pregnancy