No association of the rs4646396 SNP in the PEMT locus with schizophrenia in a Chinese case-control sample.
The present study included a total of 628 patients with schizophrenia and 588 healthy controls to replicate the genetic association between the PEMT gene and schizophreia. However, our results in this study failed to confirm our earlier finding that the C allele was preferentially transmitted by parents to their offspring affected with schizophrenia in a family-based study among the Chinese population.
Li
Heyao
H
Research Center for Neuroscience & MH Radiobiology Research Unit, School of Public Health, Jilin University, Changchun 130021, China.
Zhang
Haiying
H
Liu
Libo
L
Ju
Guizhi
G
Jin
Shunzi
S
Ye
Lin
L
Zhang
Xuan
X
Wei
Jun
J
D000328:Adult; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D050918:Phosphatidylethanolamine N-Methyltransferase / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*; D055815:Young Adult
C494489:PEMT protein, human; D050918:Phosphatidylethanolamine N-Methyltransferase