Overexpression of VCC-1 gene in human hepatocellular carcinoma cells promotes cell proliferation and invasion.
Vascular endothelial growth factor-correlated chemokine 1 (VCC-1), a novel chemokine, is hypothesized to be associated with carcinogenesis. VCC-1 is expressed in hepatocellular carcinoma (HCC) cells, but its function remains unknown. To investigate the molecular effects of VCC-1 on HCC cells, the HCC cell line SMMC7721 was stably transfected with the recombinant plasmid pcDNA3.1/VCC-1. Our data demonstrated that overexpression of VCC-1 in SMMC7721 cells significantly enhanced the cellular proliferation, invasive ability, and tumor growth, when compared with both empty vector control cells and parental cells. These results strongly suggest that VCC-1 plays an important role in SMMC7721 invasion and tumor growth, and indicate that VCC-1 may serve as a potential biomarker for anti-HCC therapies.
Mu
Xia
X
School of Biotechnology, Southern Medical University, Guangzhou, China.
Chen
Yao
Y
Wang
Shuihai
S
Huang
Xiang
X
Pan
Huazhen
H
Li
Ming
M
D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000473:pathology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D018925:Chemokines / Q000235:genetics*; D019743:Chemokines, CXC; D018450:Disease Progression; D005260:Female; D015870:Gene Expression; D006801:Humans; D008297:Male; D051379:Mice; D008819:Mice, Nude; D009361:Neoplasm Invasiveness; D023041:Xenograft Model Antitumor Assays
C508524:CXCL17 protein, human; D018925:Chemokines; D019743:Chemokines, CXC