A novel mouse model for the aggressive variant of NK cell and T cell large granular lymphocyte leukemia.
Murine models of disease are vital to the understanding of pathogenesis and the development of novel therapeutics. We have previously established interleukin (IL)-15 transgenic (tg) mice that demonstrate rapid proliferation of natural killer (NK) and T cells, followed by spontaneous transformation to lethal leukemia. Herein, we have characterized this model, which has many features in common with the aggressive variants of NK and T large granular lymphocyte leukemia (LGLL) in humans. The LGLL blasts are cytolytic and produce IFN-gammaex vivo. Cytogenetic analysis revealed trisomy of chromosome 17 and/or 15. This model should provide opportunities to develop effective standard therapies for this fatal disease.
Yokohama
Akihiko
A
Department of Molecular Virology, Immunology, and Medical Genetics, Department of Internal Medicine, Division of Hematology/Oncology, The Ohio State University College of Medicine, Columbus, OH, United States.
Mishra
Anjali
A
Mitsui
Takeki
T
Becknell
Brian
B
Johns
Jessica
J
Curphey
Douglas
D
Blaser
Bradley W
BW
Vandeusen
Jeffrey B
JB
Mao
Hsiaoyin
H
Yu
Jianhua
J
Caligiuri
Michael A
MA
D000818:Animals; D001752:Blast Crisis; D049109:Cell Proliferation; D033481:Chromosomes, Mammalian; D004195:Disease Models, Animal; D007371:Interferon-gamma / Q000096:biosynthesis; D019409:Interleukin-15 / Q000235:genetics; D007694:Killer Cells, Natural / Q000473:pathology; D054066:Leukemia, Large Granular Lymphocytic / Q000235:genetics / Q000473:pathology*; D051379:Mice; D008822:Mice, Transgenic; D010641:Phenotype; D013601:T-Lymphocytes / Q000473:pathology; D014314:Trisomy
D019409:Interleukin-15; D007371:Interferon-gamma