Ceratodictyols, 1-glyceryl ethers from the red alga-sponge association Ceratodictyon spongiosum/Haliclona cymaeformis.
Six 1-glyceryl ethers (1-6) were isolated from the red alga-sponge assemblage Ceratodictyon spongiosum/Haliclona cymaeformis. Structural assignments were conducted by interpretation of spectroscopic data and the modified Mosher's method. Four allylic alcohols were obtained as a pair of epimeric mixtures (3/4 and 5/6). These glyceryl ethers exhibited weak cytotoxic activity against HeLa human cervical cancer cells.
Akiyama
Takuya
T
Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.
Ueoka
Reiko
R
van Soest
Rob W M
RW
Matsunaga
Shigeki
S
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005995:Glyceryl Ethers / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D047129:Haliclona / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D015394:Molecular Structure; D000461:Rhodophyta / Q000737:chemistry*
D000970:Antineoplastic Agents; D005995:Glyceryl Ethers