title: Indirect measurement of aneurysm wall thickness using digital stethoscope.
abstract: OBJECTIVE
  No existing in vivo technique can measure aneurysm wall thickness for evaluation of rupture risk. Intracranial aneurysms produce bruits at a special range of frequency that are highly influenced by the wall thickness. Understanding of the mechanism that generates bruits may allow us to learn aneurysm behavior non-invasively.
  
  
  METHODS
  A new theory was proposed to account for an interaction between an aneurysm and its parent vessel. Four patients with ophthalmic aneurysms were studied with a digital electronic stethoscope before and after endovascular treatment. Energy spectra of bruits were obtained from digital recording at both eyes. Change of energy spectra was used as an objective indication for aneurysm bruits. Additional four cases were obtained from a previous report.
  
  
  RESULTS
  Aneurysm bruits are affected by both aneurysm size and wall thickness. These sounds disappear after coil embolization and parent artery occlusion, but not by stenting. Both large and small aneurysms generate sounds at high frequency. Aneurysms at 6 mm produced very low frequency sound. Wall thickness decreases with aneurysm size, and the decrease is more pronounced at 8 mm.
  
  
  CONCLUSIONS
  Interaction between an intracranial aneurysm and its parent vessel is important in interpretation of aneurysm bruits. An analysis of in vivo measurements shows a rapid decline in wall thickness for 8 mm aneurysms.
authors: Department of Radiology, Baylor College of Medicine, Houston, TX 77030, USA. jou@bcm.tmc.edu
authors: Liang-Der
authors: LD
authors: Jou
authors: Michel E
authors: ME
authors: Mawad
mesh_terms: D004621:Embolization, Therapeutic / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D007839:Functional Laterality; D006801:Humans; D002532:Intracranial Aneurysm / Q000175:diagnosis* / Q000601:surgery; D008875:Middle Aged; D012815:Signal Processing, Computer-Assisted; D013057:Spectrum Analysis / Q000379:methods; D019023:Stethoscopes