title: Contribution of the amount of contrast media used in pulmonary CT angiography to assess the diagnostic value of CT venography; comparison of 100 and 150ml of contrast media.
abstract: OBJECTIVE
  To prospectively compare the vascular attenuation achieved with 100ml iohexol (350mgI/ml) 75% with that achieved with 150ml iohexol (350mgI/ml) 75% for computed tomography (CT) venography, which was performed after CT pulmonary angiography.
  
  
  METHODS
  A total of 122 patients were included in the study. Group A, comprising 52 patients (mean age 64.8 years, mean body weight 70.8kg) received 150ml iohexol (350mgI/ml) contrast media. Group B, comprising 70 patients (mean age 61.2 years, mean body weight 71.4kg) received 100ml iohexol (350mgI/ml) contrast medium.
  
  
  RESULTS
  Venous opacification values measured at all levels were significantly higher in group A than those in group B (p<0.001). In group B the mean HU values were between 87 and 115 and only three of the patients had HU values less than 60 at the level of femoral vein. Assuming a venous enhancement of 80HU as the cut-off value for accurate diagnosis of deep venous thrombosis, 22.8% (16/70) in group B and 7.6% (4/52; p=0.028) in group A had non-diagnostic CT venography of left femoral vein.
  
  
  CONCLUSIONS
  One hundred millilitres of contrast medium with a concentration of 350mgI/ml may produce sufficient enhancement, but 150ml of contrast medium provides better accuracy for the diagnosis of deep venous thrombosis diagnosis. For better enhancement of lower extremity deep veins, the concentration of the contrast medium and the patient's body weight may also have significance.
authors: Department of Radiology, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir, Turkey. ccalisi1@jhmi.edu
authors: C
authors: C
authors: Calisir
authors: U S
authors: US
authors: Yavas
authors: M
authors: M
authors: Kebapci
authors: A
authors: A
authors: Korkmaz
authors: R
authors: R
authors: Ozkan
mesh_terms: D000328:Adult; D000368:Aged; D000792:Angiography / Q000379:methods*; D001835:Body Weight; D003287:Contrast Media / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007472:Iohexol / Q000008:administration & dosage*; D007866:Leg / Q000098:blood supply; D008297:Male; D008875:Middle Aged; D010690:Phlebography / Q000379:methods; D011446:Prospective Studies; D011651:Pulmonary Artery / Q000000981:diagnostic imaging; D011655:Pulmonary Embolism / Q000000981:diagnostic imaging* / Q000209:etiology; D013997:Time Factors; D014057:Tomography, X-Ray Computed / Q000379:methods*; D020246:Venous Thrombosis / Q000150:complications / Q000000981:diagnostic imaging*
chemical_list: D003287:Contrast Media; D007472:Iohexol