Increased peripheral blood mitochondrial DNA in type 2 diabetic patients with nephropathy.
We report that mitochondrial DNA (MtDNA) copy numbers are increased in peripheral blood of patients with diabetic nephropathy (DN). Using qPCR for quantitation, we found a 2-4-fold significant increase (p<0.05) in the mean MtDNA values in DN patients vs. healthy controls and diabetics without nephropathy. Increased MtDNA in DN could contribute to increased oxidative stress.
Malik
Afshan N
AN
Diabetes Research Group, Division of Reproduction and Endocrinology, King's College London, London Bridge, London, UK. afshan.malik@kcl.ac.uk
Shahni
Rojeen
R
Iqbal
Masud M
MM
D000328:Adult; D000368:Aged; D015992:Body Mass Index; D004247:DNA / Q000097:blood / Q000235:genetics; D004272:DNA, Mitochondrial / Q000097:blood* / Q000235:genetics; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000235:genetics; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications / Q000235:genetics*; D003928:Diabetic Nephropathies / Q000097:blood / Q000235:genetics*; D006801:Humans; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology
D004272:DNA, Mitochondrial; D004247:DNA