Acute renal failure following detergent ingestion.
A 42-year-old woman with a history of depression and epilepsy ingested two types of household detergent and developed gastrointestinal symptoms, and subsequently acute renal failure. Coingestants included nontoxic quantities of paracetamol and therapeutic doses of sodium valproate and fluoxetine. The patient developed acute renal failure, and also had fever and unilateral ear inflammation. The acute renal failure resolved four days later. Patients presenting with detergent poisoning are typically screened and treated for gastrointestinal and respiratory toxicity. We discuss the mechanism of development of acute renal failure in our patient, review the literature linking detergent poisoning and nephrotoxicity, and propose a direct relationship between detergent poisoning and acute renal failure.
Lim
Y C
YC
Department of General Medicine, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore. linyanqian@gmail.com
D000082:Acetaminophen / Q000494:pharmacology; D058186:Acute Kidney Injury / Q000139:chemically induced / Q000209:etiology* / Q000628:therapy; D000328:Adult; D003863:Depression / Q000188:drug therapy; D003902:Detergents / Q000009:adverse effects* / Q000506:poisoning*; D004435:Eating; D005260:Female; D005473:Fluoxetine / Q000494:pharmacology; D006801:Humans; D016896:Treatment Outcome; D014635:Valproic Acid / Q000494:pharmacology
D003902:Detergents; D005473:Fluoxetine; D000082:Acetaminophen; D014635:Valproic Acid