Rhodium catalyzed enantioselective cyclization of substituted imidazoles via C-H bond activation.
The enantioselective intramolecular alkylation of substituted imidazoles with enantiomeric excesses up to 98% has been accomplished by rhodium catalyzed C-H bond functionalization with (S,S',R,R')TangPhos as the chiral ligand.
Tsai
Andy S
AS
Department of Chemistry, University of California, Berkeley, CA 94720-1460, USA.
Wilson
Rebecca M
RM
Harada
Hitoshi
H
Bergman
Robert G
RG
Ellman
Jonathan A
JA
D002384:Catalysis; D003500:Cyclization; D007093:Imidazoles / Q000737:chemistry* / Q000378:metabolism*; D012238:Rhodium / Q000494:pharmacology*
D007093:Imidazoles; D012238:Rhodium