title: Novel and direct transformation of methyl ketones or carbinols to primary amides by employing aqueous ammonia.
abstract: A novel and direct transformation of aryl, heteroaryl, vinyl, or ethynyl methyl ketones or carbinols to corresponding primary amides has been developed. An iodine-NH(3).H(2)O system was proven to be efficient for this reaction and afforded the expected products with good yields in aqueous media. A tandem Lieben-Haller-Bauer reaction mechanism was involved in this type of reaction and is proposed for the first time.
authors: Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, Central China Normal University, Wuhan 430079, PR China.
authors: Liping
authors: L
authors: Cao
authors: Jiaoyang
authors: J
authors: Ding
authors: Meng
authors: M
authors: Gao
authors: Zihua
authors: Z
authors: Wang
authors: Juan
authors: J
authors: Li
authors: Anxin
authors: A
authors: Wu
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D000641:Ammonia / Q000737:chemistry*; D002384:Catalysis; D007455:Iodine / Q000737:chemistry; D007659:Ketones / Q000737:chemistry*; D000432:Methanol / Q000737:chemistry*; D015394:Molecular Structure; D014867:Water / Q000737:chemistry
chemical_list: D000577:Amides; D007659:Ketones; D014867:Water; D000641:Ammonia; D007455:Iodine; D000432:Methanol