Quality of life in treatment-seeking patients with obsessive-compulsive disorder with and without major depressive disorder.
OBJECTIVE
To compare the quality of life of patients with obsessive-compulsive disorder (OCD) with and without depression comorbidity.


METHODS
Treatment-seeking outpatients (n = 56) with OCD (n = 28) or comorbid OCD and major depressive disorder (MDD) (n = 28), matched by age, sex, and antidepressant medication use, completed a multidimensional measure of quality of life.


RESULTS
Patients with comorbid OCD and MDD reported significantly greater decrements in their subjective feelings, social relations, and a composite measure of general activities (for example, overall well-being and life satisfaction) in comparison with patients with OCD without MDD. These differences were not owing to the presence of other Axis I comorbid disorders.


CONCLUSIONS
Treatments addressing depression comorbidity in the context of primary OCD are required to improve the quality of life of this severely affected population of OCD sufferers.
Cassin
Stephanie E
SE
Department of Psychiatry, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Ontario.
Richter
Margaret A
MA
Zhang
K Anne
KA
Rector
Neil A
NA
D000203:Activities of Daily Living / Q000523:psychology; D000328:Adult; D003131:Combined Modality Therapy; D015897:Comorbidity; D003430:Cross-Sectional Studies; D003865:Major Depressive Disorder / Q000453:epidemiology / Q000523:psychology* / Q000628:therapy; D005260:Female; D006785:Hospitals, University; D006801:Humans; D007398:Interpersonal Relations; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000453:epidemiology / Q000523:psychology* / Q000628:therapy; D009864:Ontario; D010342:Patient Acceptance of Health Care / Q000523:psychology*; D010549:Personal Satisfaction; D011788:Quality of Life / Q000523:psychology*