title: Study on the anthraquinones separated from the cultivation of Trichoderma harzianum strain Th-R16 and their biological activity.
abstract: The biocontrol fungal species of Trichoderma, which colonizes plant roots, are well-known for their potential to control plant pathogens. Six anthraquinones, of which four have been identified for the first time from Trichoderma and two have already been reported in other strains, were purified from Trichoderma harzianum strain Th-R16 to evaluate their biological activities. The structures of the compounds were determined by one- and two-dimensional NMR. The compounds were shown to exhibit stronger antifungal activity than antibacterial activity. Low yield compounds, like 1,5-dihydroxy-3-hydroxymethyl-9,10-anthraquinone, were found to be more active against fungal pathogens than pachybasin and crysophanol, which were found to be the major extracellular metabolites. Test anthraquinones with higher oxidation numbers had better antifungal activity, and their activities were concentration-dependent.
authors: Department of Molecular Biotechnology, Da-Yeh University, Changhua, Taiwan.
authors: Shu-Ying
authors: SY
authors: Liu
authors: Chaur-Tsuen
authors: CT
authors: Lo
authors: Marthandam Asokan
authors: MA
authors: Shibu
authors: Yann-Lii
authors: YL
authors: Leu
authors: Bo-Yuan
authors: BY
authors: Jen
authors: Kou-Cheng
authors: KC
authors: Peng
mesh_terms: D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D005658:Fungi / Q000187:drug effects*; D010935:Plant Diseases / Q000382:microbiology; D014242:Trichoderma / Q000737:chemistry*
chemical_list: D000880:Anthraquinones