[Study on the antitussive and antiasthmatic effects of Radix Fici Hirtae].
OBJECTIVE
To observe the antitussive and antiasthmatic effects of Radix Fici Hirtae (RFH).


METHODS
Antitussive effects were observed by ammonia water steaming test in mice and by citric acid test in guinea pigs. Antiasthmatic actions in guinea pigs were observed by histamine and acetylcholine ultrasonic atomization test, involved isolated guinea pig tracheal smoth muscle experiment and anaphylactic shock of guinea pigs.


RESULTS
RFH decreased the frequency of cough induced by ammonia in mice and by citric acid in guinea pig, prolonged the latent period of cough and inhibited the experimental asthma by histamine and acetylcholine solution in conscious guinea pigs, antagonisted the contraction of tracheal smooth muscle by histamine phosphate in guinea pigs and could compete anaphylactic shock in guinea pigs.


CONCLUSIONS
RFH has obvious antitussive and antiasthmatic effects.
Zhou
Tian-Nong
TN
College of Chinese Traditional Medicine, Guangzhou University of TCM, Guangzhou 510405, China.
Tang
Li-Hai
LH
Huang
Shi-Chong
SC
Lu
Dan-Dan
DD
Wang
Yan
Y
Liu
Liang-Feng
LF
Lai
Ping
P
Ye
Mu-Rong
MR
D000109:Acetylcholine / Q000008:administration & dosage; D000707:Anaphylaxis / Q000139:chemically induced / Q000188:drug therapy; D000818:Animals; D000996:Antitussive Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D001249:Asthma / Q000139:chemically induced / Q000188:drug therapy; D027885:Astragalus propinquus / Q000737:chemistry; D019343:Citric Acid / Q000008:administration & dosage; D003371:Cough / Q000139:chemically induced / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D005100:Expectorants / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006168:Guinea Pigs; D006632:Histamine; D008297:Male; D051379:Mice; D029586:Moraceae / Q000737:chemistry; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D008517:Phytotherapy; D018517:Plant Roots / Q000737:chemistry; D011897:Random Allocation; D014132:Trachea / Q000187:drug effects
D000996:Antitussive Agents; D004365:Drugs, Chinese Herbal; D005100:Expectorants; D019343:Citric Acid; D006632:Histamine; D000109:Acetylcholine