Development of a novel expression, ZI MAX/K ZI, for determination of the counter-anion effect on the antimicrobial activity of tetrabutylammonium salts.
Due to the increasing number of strains of drug-resistant bacteria, the development of new antibiotics has become increasingly important. The antibacterial properties of quaternary amines and their derivatives on both Gram-positive and Gram-negative bacteria are well known. However, an encompassing study with specific emphasis on the role of the counter-anion has not been reported in the literature. By monitoring the Zone of Inhibition of various concentrations of tetrabutylammonium (TBA) salts, we observed that the counter anion plays a significant role in activity. We developed a novel method of reporting activity using zone of inhibition tests (ZI(MAX)/K(ZI)) and found it to be strongly correlated with the minimum inhibitory concentration (MIC).
Ingalsbe
Michelle L
ML
Department of Chemistry, Biochemistry, and Physics, Niagara University, Niagara University, NY 14109, USA.
Denis
Jeffrey D St
JD
McGahan
Megan E
ME
Steiner
Walter W
WW
Priefer
Ronny
R
D000838:Anions / Q000737:chemistry* / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D052978:Disk Diffusion Antimicrobial Tests; D000644:Quaternary Ammonium Compounds / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000838:Anions; D000890:Anti-Infective Agents; D000644:Quaternary Ammonium Compounds; C009405:tetrabutylammonium