Nephrotic-range proteinuria with small glomerular fibrillary deposits in a patient on diphenylhydantoin treatment.
BACKGROUND
Although the exact role of the diphenylhydantoin treatment on the immune system is still unclear, prolonged administration of diphenylhydantoin has been suggested to be associated with immune-based disorders and syndromes.


METHODS
A case of fibrillary glomerulonephritis associated with DPH treatment is reported. This is the first reported case of fibrillary glomerulonephritis associated with this commonly used common anticonvulsive drug.


CONCLUSIONS
A more routine surveillance for proteinuria in patients receiving DPH is recommended.
Kiykim
Ahmet Alper
AA
Department of Internal Medicine, Division of Nephrology, Faculty of Medicine, University of Mersin, Mersin, Turkey.
Genctoy
Gultekin
G
Horoz
Mehmet
M
Sari
Sibel
S
Gok
Ebru
E
Coskun
Banu
B
Yilmaz
Nejat
N
Gurses
Iclal
I
D005921:Glomerulonephritis / Q000139:chemically induced* / Q000150:complications* / Q000473:pathology; D006801:Humans; D007678:Kidney Glomerulus / Q000473:pathology* / Q000648:ultrastructure; D008297:Male; D008875:Middle Aged; D010503:Periodic Acid-Schiff Reaction; D010672:Phenytoin / Q000009:adverse effects*; D011507:Proteinuria / Q000139:chemically induced* / Q000150:complications* / Q000473:pathology
D010672:Phenytoin