Sinus histiocytosis with massive lymphadenopathy: a case report with pleural effusion and cervical lymphadenopathy.
Sinus histiocytosis with massive lymphadenopathy (SHML) is a rare disorder characterized by a nonneoplastic proliferation of distinctive histiocyte cells within lymph node sinuses and lymphatics in extranodal sites. SHML occurs worldwide and is primarily a disease of childhood and early adulthood. A 26-yr-old man presented with painless palpable lymph node in cervical area. Radiographic studies revealed pleural effusion with lymphadenopathy and calcification in mediastinum. The cervical lymph node biopsy showed dilated sinuses filled with histiocytes with clear cytoplasm. The cells stained positive with CD68 and S-100. These cytologic and immunohistochemical findings were considered consistent with the diagnosis of SHML.
Ju
Jinyung
J
Department of Internal Medicine, Chonnam National University Hospital, Gwangju, Korea.
Kwon
Yong Soo
YS
Jo
Kae Jung
KJ
Chae
Dong Ryeol
DR
Lim
Jung Hwan
JH
Ban
Hee Jung
HJ
Chi
Su Young
SY
Oh
In Jae
IJ
Kim
Ku Sik
KS
Kim
Yu Il
YI
Kim
Young Chul
YC
Lim
Sung Chul
SC
D000328:Adult; D015703:Antigens, CD / Q000378:metabolism; D015214:Antigens, Differentiation, Myelomonocytic / Q000378:metabolism; D006644:Histiocytes / Q000473:pathology; D015618:Histiocytosis, Sinus / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D009333:Neck; D010996:Pleural Effusion / Q000000981:diagnostic imaging*; D009418:S100 Proteins / Q000378:metabolism; D014057:Tomography, X-Ray Computed; D000097382:CD68 Molecule
D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D009418:S100 Proteins; C067980:CD68 antigen, human; D000097382:CD68 Molecule