Cell transplantation strategies for retinal repair.
Cell transplantation is a novel therapeutic strategy to restore visual responses to the degenerate adult neural retina and represents an exciting area of regenerative neurotherapy. So far, it has been shown that transplanted postmitotic photoreceptor precursors are able to functionally integrate into the adult mouse neural retina. In this review, we discuss the differentiation of photoreceptor cells from both adult and embryonic-derived stem cells and their potential for retinal cell transplantation. We also discuss the strategies used to overcome barriers present in the degenerate neural retina and improve retinal cell integration. Finally, we consider the future translation of retinal cell therapy as a therapeutic strategy to treat retinal degeneration.
West
E L
EL
Department of Genetics, UCL Institute of Ophthalmology, London, UK.
Pearson
R A
RA
MacLaren
R E
RE
Sowden
J C
JC
Ali
R R
RR
D000818:Animals; D006801:Humans; D051379:Mice; D010786:Photoreceptor Cells / Q000637:transplantation*; D012160:Retina / Q000637:transplantation*; D012164:Retinal Diseases / Q000601:surgery*; D033581:Stem Cell Transplantation / Q000379:methods*