title: Complex adaptive systems allostasis in fibromyalgia.
abstract: Fibromyalgia (FM) can be conceptualized as a failed attempt of our main complex adaptive system (the autonomic nervous system) to adjust to a hostile environment. FM cannot be fully understood through the prevailing linear-reductionist medical model. Conversely, FM can be explained using the new complexity theory paradigms. Relentless sympathetic hyperactivity in FM may be a sign of allostasis. Similarly sympathetic hyporeactivity to stress may indicate allostatic load. Dorsal root ganglia have been suggested as important sympathetic-nociceptive short-circuit sites. Autonomic dysfunction also explains non-pain-related FM features. Preliminary genetic evidence supports FM's dysautonomic nature. A scientific holistic therapy is proposed to harmonize rigid complex systems and, in doing so, to help to improve FM symptoms.
authors: Rheumatology Department, National Cardiology Institute, Mexico City, Mexico. mmlavin@terra.com.mx
authors: Manuel
authors: M
authors: Martinez-Lavin
authors: Angelica
authors: A
authors: Vargas
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology*; D005356:Fibromyalgia / Q000503:physiopathology*; D005727:Ganglia, Spinal / Q000503:physiopathology*; D006801:Humans; D009437:Neuralgia / Q000503:physiopathology*; D009619:Nociceptors / Q000502:physiology*