Organocatalytic enantioselective synthesis of nitrogen-substituted dihydropyran-2-ones, a key synthetic intermediate of 1beta-methylcarbapenems.
Organocatalytic enantioselective cycloadditions providing nitrogen-substituted dihydropyran-2-ones were developed in two catalytic systems. The (3R,4R)-product was a versatile intermediate in the synthesis of 1beta-methylcarbapenem antibiotics.
Kobayashi
Shoji
S
Department of Chemistry, Graduate School of Science, Osaka Prefecture University, Sakai 599-8531, Japan. koba@c.s.osakafu-u.ac.jp
Kinoshita
Tatsuhiro
T
Uehara
Hisatoshi
H
Sudo
Tomoko
T
Ryu
Ilhyong
I