title: Synthesis, characterization, antibacterial and anti-inflammatory activities of enoxacin metal complexes.
abstract: The present work comprises the synthesis of enoxacin (Heno) complexes with various transition metals. Two types of complexes [M(eno)(2)(H(2)O)(2)]3H(2)O(M = Cu(II), Ni(II) or Mn(II)) and [M(eno)(H(2)O)(2)]Cl . 4H(2)O (M = Fe(III)) were obtained. The complexes were characterized by different physicochemical, spectroscopic, and elemental analysis. Results suggest that enoxacin interacts with the metals as a monoanionic bidentate ligand. These complexes were also tested for their antibacterial activity against eleven (11) different microorganisms, and the results were compared with the parent drug. Moreover all the metal complexes were also tested for their ability to scavenge reactive oxygen species where by Mn(II) and Cu(II) complexes exhibited potential to mediate anti-inflammatory response.
authors: Department of Chemistry, University of Karachi, Karachi-75270, Pakistan. msarayne1@gmail.com
authors: Saeed
authors: S
authors: Arayne
authors: Najma
authors: N
authors: Sultana
authors: Urooj
authors: U
authors: Haroon
authors: M Ahmed
authors: MA
authors: Mesaik