A customized and versatile high-density genotyping array for the mouse.
We designed a high-density mouse genotyping array containing 623,124 single-nucleotide polymorphisms that captures the known genetic variation present in the laboratory mouse. The array also contains 916,269 invariant genomic probes targeted to functional elements and regions known to harbor segmental duplications. The array opens the door to the characterization of genetic diversity, copy-number variation, allele-specific gene expression and DNA methylation, and will extend the successes of human genome-wide association studies to the mouse.
Yang
Hyuna
H
The Jackson Laboratory, Bar Harbor, Maine, USA.
Ding
Yueming
Y
Hutchins
Lucie N
LN
Szatkiewicz
Jin
J
Bell
Timothy A
TA
Paigen
Beverly J
BJ
Graber
Joel H
JH
de Villena
Fernando Pardo-Manuel
FP
Churchill
Gary A
GA
D000818:Animals; D001482:Base Composition; D004247:DNA / Q000235:genetics; D005838:Genotype; D051379:Mice; D009693:Nucleic Acid Hybridization; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D020641:Polymorphism, Single Nucleotide
D004247:DNA