title: Effect of fat emulsion (Fabuless) on orocecal transit time in healthy men.
abstract: BACKGROUND
  Given the growing prevalence of overweight and related health consequences, there is increased interest in the search for novel dietary strategies for weight control. A food ingredient, an emulsion based on palm and oat oil (Fabuless, previously known as Olibra), has been associated with short-term reductions of food intake, induction of satiety, alternation in the satiety hormones, as well as long-term effects on weight control. The mechanism by which it can exert these effects is so far unclear, though it has been suggested that the "ileal break" may play a role in increasing gastrointestinal transit time. The aim of this study was to investigate the effects of this stable fat emulsion on orocecal transit time in healthy men.
  
  
  METHODS
  In a controlled, double-blind, cross-over-designed study, 15 healthy men (aged 20-59 years, body mass index (BMI) 22-28), randomly allocated to two treatments, consumed the stable fat emulsion or a milk fat in yoghurt during two days of investigation, with an interval of 1 week. Orocecal transit time was determined by following blood sulfapyridine levels, which is a metabolite of salazopyrine in the colon.
  
  
  RESULTS
  A statistically significant delay in the appearance of sulfapyridine in serum was obtained after active treatment versus control treatment, corresponding to a 45-min longer orocecal transit time due to fat emulsion consumption.
  
  
  CONCLUSIONS
  This study provides the first evidence to suggest that this stable fat emulsion may affect the ileal brake mechanism by slowing down the gastrointestinal transit time, which might explain the weight control and appetite suppression previously observed in association with this emulsion.
authors: Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Uppsala, Sweden. arvo.hanni@akademiska.se
authors: Arvo
authors: A
authors: Haenni
authors: Birgitta
authors: B
authors: Sundberg
authors: Nahid
authors: N
authors: Yazdanpandah
authors: Annika
authors: A
authors: Viberg
authors: Johan
authors: J
authors: Olsson
mesh_terms: D000328:Adult; D001066:Appetite / Q000187:drug effects*; D001069:Appetite Regulation; D015992:Body Mass Index; D001835:Body Weight; D004041:Dietary Fats / Q000008:administration & dosage*; D004311:Double-Blind Method; D004655:Emulsions / Q000008:administration & dosage*; D005260:Female; D005772:Gastrointestinal Transit; D006801:Humans; D008297:Male; D008875:Middle Aged; D013997:Time Factors
chemical_list: D004041:Dietary Fats; D004655:Emulsions