Separation and preconcentration of aluminum in parenteral solutions and bottled mineral water using different analytical techniques.
A new method is reported for the separation of aluminum ions [Al(III)] from interfering elements in parenteral and pharmaceutical solutions (PS) and bottled mineral water (BMW) samples, through solid-phase extraction with 2-methyl-8-hydroxyquinoline (quinaldine) adsorbed onto activated silica gel. While the enrichment step of separated Al(III) was carried out by cloud point extraction (CPE) using 8-hydroxyquinoline as complexing reagent, the resulted complex was entrapped in a non-ionic surfactant octylphenoxypolyethoxyethanol (Triton X-114). The enriched Al(III) in sample solutions were determined by spectrofluorometry (SPF) at lambda(excitation) 370 nm and lambda(emission) 510 nm, and flame atomic absorption spectrometry (FAAS) for comparative purpose. The variables affecting the complexation and extraction steps were studied and optimized. The validity of methodology was checked with certified reference material of water and standard addition method. The enrichment factor and detection limit of Al(III) for the preconcentration of 50 ml of PS and BMW were found to be 100 and 0.25 microg/L, respectively. The proposed method has been applied for the determination of trace amount of Al(III) in PS and BMW samples with satisfactory results. In PS the levels of Al(III) are above than permissible limit (25 microg/L).
Kazi
Tasneem G
TG
Center of Excellence in Analytical Chemistry, University of Sindh, Jamshoro 76080, Pakistan. tgkazi@yahoo.com
Khan
Sumaira
S
Baig
Jameel A
JA
Kolachi
Nida F
NF
Afridi
Hassan I
HI
Kandhro
Ghulam A
GA
Kumar
Sham
S
Shah
Abdul Q
AQ
D000535:Aluminum / Q000302:isolation & purification*; D008722:Methods; D008900:Mineral Waters / Q000032:analysis*; D019999:Pharmaceutical Solutions / Q000032:analysis*; D011798:Quinaldines; D052616:Solid Phase Extraction; D013057:Spectrum Analysis; D013501:Surface-Active Agents
D008900:Mineral Waters; D019999:Pharmaceutical Solutions; D011798:Quinaldines; D013501:Surface-Active Agents; D000535:Aluminum; C037073:2-methylquinoline