title: Pancreatic cancer: proteomic approaches to a challenging disease.
abstract: OBJECTIVE
  To describe progress in the application of proteomic approaches to advance our understanding of the biology of pancreatic cancer as well as contribute potential protein biomarkers for this disease.
  
  
  RESULTS
  Here we review proteomic studies relating to pancreatic cancer that have been published in the past 12 months. We describe novel techniques for the simplification of complex protein samples, focusing particularly on emerging methods for reducing the complexity of blood. We provide examples, where possible, of the application of these novel technologies to pancreatic cancer research.
  
  
  CONCLUSIONS
  Both the range of proteomic-based approaches and their sensitivities for the detection of low-abundance proteins has increased. This provides promise that further research will yield insight into pancreatic cancer, including valuable information on proteins that may ultimately serve as biomarkers for pancreatic cancer.
authors: Division of Surgery and Oncology, Royal Liverpool University Hospital, University of Liverpool, Liverpool, UK.
authors: Sarah
authors: S
authors: Tonack
authors: Mark
authors: M
authors: Aspinall-O'Dea
authors: John P
authors: JP
authors: Neoptolemos
authors: Eithne
authors: E
authors: Costello
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000032:analysis; D014408:Biomarkers, Tumor / Q000235:genetics; D002846:Chromatography, Affinity / Q000379:methods; D006801:Humans; D051379:Mice; D023421:Models, Animal; D010189:Pancreatic Juice / Q000737:chemistry; D010190:Pancreatic Neoplasms / Q000235:genetics* / Q000276:immunology; D010446:Peptide Fragments / Q000032:analysis; D040081:Protein Array Analysis; D040901:Proteomics / Q000379:methods*
chemical_list: D001323:Autoantibodies; D014408:Biomarkers, Tumor; D010446:Peptide Fragments