Altered release of regulated upon activation, normal T-cell expressed and secreted protein from human, normal platelets: contribution of distinct HIV-1MN gp41 peptides.
Platelets can bind HIV and, in turn, be altered in with respect to and function during HIV progression. This study examines the secretion of normal platelets after exposure to recombinant HIV-1MN gp120 or gp41 peptides. There was a modest but significant decrease in regulated upon activation, normal T-cell expressed and secreted protein production in the presence of two out of 10 peptides, which was restored by monoclonal antibodies to gp41. Our data provide novel information on possible primary interactions between platelets and HIV env proteins.
Cognasse
Fabrice
F
aEFS Auvergne-Loire, and GIMAP-EA3064, Université de Saint-Etienne--membre de l'Université de Lyon, Faculté de Médecine, Saint-Etienne, France.
Hamzeh-Cognasse
Hind
H
Berthet
Julien
J
Damien
Pauline
P
Lucht
Frédéric
F
Pozzetto
Bruno
B
Garraud
Olivier
O
D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism / Q000821:virology; D002478:Cells, Cultured; D018946:Chemokine CCL5 / Q000096:biosynthesis; D015699:HIV Envelope Protein gp120 / Q000494:pharmacology*; D015700:HIV Envelope Protein gp41 / Q000494:pharmacology*; D015497:HIV-1; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology; D011994:Recombinant Proteins / Q000494:pharmacology
D018946:Chemokine CCL5; D015699:HIV Envelope Protein gp120; D015700:HIV Envelope Protein gp41; D011994:Recombinant Proteins