title: From GH to Billy Ghrelin.
abstract: The octanoylated peptide hormone ghrelin regulates episodic growth hormone release and energy balance. Work in genetically modified mice (Kirchner et al., 2009) now shows that in vivo activity of ghrelin O-acyltransferase (GOAT), responsible for ghrelin octanoylation, decreases during fasting but increases after ingesting medium-chain fatty acid triglycerides (MCT).
authors: Department of Metabolism and Aging, The Scripps Research Institute Florida, Jupiter, FL 33458, USA. rgsmith@scripps.edu
authors: Roy G
authors: RG
authors: Smith
mesh_terms: D000217:Acyltransferases / Q000172:deficiency / Q000235:genetics / Q000378:metabolism; D000818:Animals; D005215:Fasting; D054439:Ghrelin / Q000235:genetics / Q000378:metabolism*; D013006:Growth Hormone / Q000378:metabolism*; D008565:Membrane Proteins; D051379:Mice; D008822:Mice, Transgenic; D054440:Receptors, Ghrelin / Q000378:metabolism
chemical_list: D054439:Ghrelin; D008565:Membrane Proteins; D054440:Receptors, Ghrelin; D013006:Growth Hormone; D000217:Acyltransferases; C526983:Mboat4 protein, mouse