title: Genetic aspects of behavioral neurotoxicology.
abstract: Considerable progress has been made over the past couple of decades concerning the molecular bases of neurobehavioral function and dysfunction. The field of neurobehavioral genetics is becoming mature. Genetic factors contributing to neurologic diseases such as Alzheimer's disease have been found and evidence for genetic factors contributing to other diseases such as schizophrenia and autism are likely. This genetic approach can also benefit the field of behavioral neurotoxicology. It is clear that there is substantial heterogeneity of response with behavioral impairments resulting from neurotoxicants. Many factors contribute to differential sensitivity, but it is likely that genetic variability plays a prominent role. Important discoveries concerning genetics and behavioral neurotoxicity are being made on a broad front from work with invertebrate and piscine mutant models to classic mouse knockout models and human epidemiologic studies of polymorphisms. Discovering genetic factors of susceptibility to neurobehavioral toxicity not only helps identify those at special risk, it also advances our understanding of the mechanisms by which toxicants impair neurobehavioral function in the larger population. This symposium organized by Edward Levin and Annette Kirshner, brought together researchers from the laboratories of Michael Aschner, Douglas Ruden, Ulrike Heberlein, Edward Levin and Kathleen Welsh-Bohmer conducting studies with Caenorhabditis elegans, Drosophila, fish, rodents and humans studies to determine the role of genetic factors in susceptibility to behavioral impairment from neurotoxic exposure.
authors: Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, United States. edlevin@duke.edu
authors: Edward D
authors: ED
authors: Levin
authors: Michael
authors: M
authors: Aschner
authors: Ulrike
authors: U
authors: Heberlein
authors: Douglas
authors: D
authors: Ruden
authors: Kathleen A
authors: KA
authors: Welsh-Bohmer
authors: Selena
authors: S
authors: Bartlett
authors: Karen
authors: K
authors: Berger
authors: Lang
authors: L
authors: Chen
authors: Ammon B
authors: AB
authors: Corl
authors: Donnie
authors: D
authors: Eddins
authors: Rachael
authors: R
authors: French
authors: Kathleen M
authors: KM
authors: Hayden
authors: Kirsten
authors: K
authors: Helmcke
authors: Helmut V B
authors: HV
authors: Hirsch
authors: Elwood
authors: E
authors: Linney
authors: Greg
authors: G
authors: Lnenicka
authors: Grier P
authors: GP
authors: Page
authors: Debra
authors: D
authors: Possidente
authors: Bernard
authors: B
authors: Possidente
authors: Annette
authors: A
authors: Kirshner
mesh_terms: D000818:Animals; D001519:Behavior / Q000187:drug effects*; D004195:Disease Models, Animal; D005823:Genetics; D006801:Humans; D020258:Neurotoxicity Syndromes / Q000235:genetics / Q000503:physiopathology / Q000523:psychology; D009498:Neurotoxins / Q000633:toxicity*; D010802:Phylogeny; D014116:Toxicology
chemical_list: D009498:Neurotoxins