title: CT staging of loco-regional breast cancer recurrence. A worthwhile practice?
abstract: OBJECTIVE
  To assess the usefulness of computed tomography of the chest, abdomen, and pelvis (CTCAP) in the detection of metastatic disease in patients presenting with loco-regional recurrence of breast cancer, and to identify subgroups particularly likely to have metastases.
  
  
  METHODS
  Over a 32-month period, 63 patients with 65 recurrences underwent CTCAP, and were identified from the hospital's computerized radiology system.
  
  
  RESULTS
  Twenty-one patients (32%) had metastases, including bony (n=5, 8%), liver (n=7, 11%), and thoracic disease (n=11, 17%). Patients with recurrence in a conserved breast had lower rates of metastasis on CT than those with other sites of recurrence [three of 21 (14%) versus 18 of 44 (41%), p=0.03]. Patients younger than 50 years at primary diagnosis or younger than 60 years at recurrence had statistically significantly higher rates of metastasis than older patients [10 of 16 (63%) versus 11 of 48 (23%), p=0.003, and 13 of 23 (57%) versus eight of 42 (19%), p=0.002, respectively].
  
  
  CONCLUSIONS
  CT staging of patients presenting with loco-regional recurrence of breast cancer is a worthwhile practice. Younger patients and those with recurrence other than in the conserved breast are particularly likely to have metastatic disease.
authors: Nottingham Breast Institute, Nottingham, UK. drsarahtennant@hotmail.com
authors: S
authors: S
authors: Tennant
authors: A
authors: A
authors: Evans
authors: D
authors: D
authors: Macmillan
authors: A
authors: A
authors: Lee
authors: E
authors: E
authors: Cornford
authors: J
authors: J
authors: James
authors: I
authors: I
authors: Ellis
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001859:Bone Neoplasms / Q000556:secondary; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary; D008175:Lung Neoplasms / Q000556:secondary; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging; D009367:Neoplasm Staging / Q000379:methods*; D010997:Pleural Neoplasms / Q000556:secondary; D014057:Tomography, X-Ray Computed / Q000379:methods*