title: Effective treatment of intractable skin ulcers using allogeneic cultured dermal substitutes in patients with systemic lupus erythematosus.
abstract: Skin ulcers in systemic lupus erythematosus (SLE) patients are non-healing or intractable, because various factors or complications, including vasculitis and immunosuppressants, impair wound healing. In the present study, we applied cultured dermal substitutes (CDSs) to 3 cases of SLE skin ulcers because various systemic or topical therapies were ineffective. CDSs are prepared by culturing human fibroblasts on two-layered spongy matrices of hyaluronic acid and atelo-collagen, and they effectively promote the healing of severe skin defects. After using CDSs in the 3 cases, healthy granulation tissues formed within 6 weeks, and skin grafts were successfully performed. These results indicate that allogeneic CDSs provide new therapeutic alternatives as topical therapies for intractable skin ulcers in SLE.
authors: Department of Dermatology, School of Medicine, Wakayama Medical University, 811-1, Kimiidera, Wakayama, Japan. seikotoy@wakayama-med.ac.jp
authors: Seiko
authors: S
authors: Toyozawa
authors: Yuki
authors: Y
authors: Yamamoto
authors: Akiko
authors: A
authors: Kishioka
authors: Nozomi
authors: N
authors: Yonei
authors: Nobuo
authors: N
authors: Kanazawa
authors: Yasuhiro
authors: Y
authors: Matsumoto
authors: Yoshimitsu
authors: Y
authors: Kuroyanagi
authors: Fukumi
authors: F
authors: Furukawa
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005347:Fibroblasts / Q000166:cytology; D006801:Humans; D007866:Leg / Q000473:pathology; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000473:pathology / Q000601:surgery*; D012720:Severity of Illness Index; D016038:Skin Transplantation; D012883:Skin Ulcer / Q000209:etiology / Q000473:pathology / Q000601:surgery*; D023822:Tissue Engineering / Q000379:methods*; D014184:Transplantation, Homologous; D014945:Wound Healing