title: Evidence-based treatment paradigms for depressed patients with pain and physical symptoms.
abstract: Some antidepressants may be efficacious in alleviating pain. While few studies have directly compared antidepressants for the treatment of painful physical symptoms, meta-analyses of efficacy studies have found that antidepressants that act at serotonergic and noradrenergic neurotransmitters, such as some tricyclics and serotonin-norepinephrine reuptake inhibitors (SNRIs), may alleviate pain independently of their effects on mood. These dual-action agents have more consistently shown efficacy for pain than single-action agents.
authors: Departments of Psychiatry and Behavioral Sciences, Neurological Surgery, and Anesthesiology, University of Miami Miller School of Medicine, Miami, Fla., USA.
authors: David A
authors: DA
authors: Fishbain
mesh_terms: D000928:Antidepressive Agents / Q000627:therapeutic use; D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D006801:Humans; D014179:Neurotransmitter Uptake Inhibitors / Q000627:therapeutic use*; D010146:Pain / Q000188:drug therapy*; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents; D000929:Antidepressive Agents, Tricyclic; D014179:Neurotransmitter Uptake Inhibitors; D017367:Selective Serotonin Reuptake Inhibitors