JBIR-15, a new aspochracin derivative, isolated from a sponge-derived fungus, Aspergillus sclerotiorum Huber Sp080903f04.
In the course of our chemical screening program for novel metabolites by LC-MS monitoring, we isolated a new aspochracin derivative, JBIR-15 (1), together with aspochracin, from the culture broth of a sponge-derived fungus, Aspergillus sclerotiorum Huber Sp080903f04. The structure of 1 was determined to be N-demethyl aspochracin at the alanyl residue on the basis of extensive NMR and MS analyses.
Motohashi
Keiichiro
K
Biomedicinal Information Research Center, Japan Biological Informatics Consortium, Tokyo, Japan.
Inaba
Shigeki
S
Takagi
Motoki
M
Shin-ya
Kazuo
K
D001230:Aspergillus / Q000737:chemistry* / Q000378:metabolism; D005285:Fermentation; D007769:Lactams / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy
C545097:JBIR-15; D007769:Lactams