Minocycline-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome with persistent myocarditis.
Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a rare serious adverse effect associated with a variety of medications. We present a case of minocycline-induced DRESS syndrome, which resulted in acute renal failure, transient thyroiditis, and transaminitis, and a persistent lymphocytic myocarditis resulting in congestive heart failure. To our knowledge, this is the third reported case of minocycline-induced myocarditis. Additionally, we report successful plasmapheresis and rituximab treatment for minocycline-induced myocarditis associated with the DRESS syndrome.
Shaughnessy
Kerry K
KK
Department of Dermatology, Eastern Virginia Medical School, Norfolk, Virginia 23507, USA.
Bouchard
Susan M
SM
Mohr
Melinda R
MR
Herre
John M
JM
Salkey
Kimberly S
KS
D000152:Acne Vulgaris / Q000188:drug therapy; D000328:Adult; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D058846:Antibodies, Monoclonal, Murine-Derived; D003875:Drug Eruptions / Q000188:drug therapy / Q000209:etiology*; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D004802:Eosinophilia / Q000139:chemically induced*; D005260:Female; D006801:Humans; D008911:Minocycline / Q000009:adverse effects*; D009205:Myocarditis / Q000139:chemically induced* / Q000188:drug therapy; D010956:Plasmapheresis; D000069283:Rituximab
D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D000069283:Rituximab; D008911:Minocycline