title: Composition and biological significance of the human Nalpha-terminal acetyltransferases.
abstract: Protein Nalpha-terminal acetylation is one of the most common protein modifications in eukaryotic cells, occurring on approximately 80% of soluble human proteins. An increasing number of studies links Nalpha-terminal acetylation to cell differentiation, cell cycle, cell survival, and cancer. Thus, Nalpha-terminal acetylation is an essential modification for normal cell function in humans. Still, little is known about the functional role of Nalpha-terminal acetylation. Recently, the three major human N-acetyltransferase complexes, hNatA, hNatB and hNatC, were identified and characterized. We here summarize the identified N-terminal acetyltransferase complexes in humans, and we review the biological studies on Nalpha-terminal acetylation in humans and other higher eukaryotes.
authors: Department of Molecular Biology, University of Bergen, N-5020 Bergen, Norway.|Department of Surgical Sciences, University of Bergen, N-5020 Bergen, Norway.|Department of Surgery, Haukeland University Hospital, N-5021 Bergen, Norway.
authors: Kristian K
authors: KK
authors: Starheim
authors: Department of Molecular Biology, University of Bergen, N-5020 Bergen, Norway.|Department of Surgical Sciences, University of Bergen, N-5020 Bergen, Norway.|Department of Surgery, Haukeland University Hospital, N-5021 Bergen, Norway.
authors: Darina
authors: D
authors: Gromyko
authors: Department of Molecular Biology, University of Bergen, N-5020 Bergen, Norway.|Department of Surgical Sciences, University of Bergen, N-5020 Bergen, Norway.
authors: Rolf
authors: R
authors: Velde
authors: Department of Surgical Sciences, University of Bergen, N-5020 Bergen, Norway.|Department of Surgery, Haukeland University Hospital, N-5021 Bergen, Norway.
authors: Jan Erik
authors: JE
authors: Varhaug
authors: Department of Molecular Biology, University of Bergen, N-5020 Bergen, Norway.|Department of Surgical Sciences, University of Bergen, N-5020 Bergen, Norway.|Department of Surgery, Haukeland University Hospital, N-5021 Bergen, Norway.
authors: Thomas
authors: T
authors: Arnesen