title: Sclerosing angiomatoid nodular transformation (SANT) of the spleen: a report of 3 cases.
abstract: The authors describe 3 cases of sclerosing angiomatoid nodular transformation (SANT) of the spleen diagnosed at Memorial Sloan-Kettering Cancer Center within a 1-year period (July 2008 to June 2009). All patients were female, older than 50, with lesions ranging in size from 2 to 4 cm. All were alive and well after splenectomy. All the cases showed characteristic histological and immunophenotypical findings as previously described in the literature, including scattered IgG4positive plasma cells in the fibrosclerotic stroma. Of the 3 patients, 2 had a history of carcinoma, and metastasis was of concern, but a PET scan in one of these patients showed minimal to absent FDG activity suggesting that this process was of a benign indolent nature. However, in 1 patient, a PET scan revealed positive FDG activity, heightening clinical concern for malignancy.
authors: Department of Pathology, Hospital of the University of Pennsylvania, Philadelphia, USA.
authors: Aashiyana F
authors: AF
authors: Koreishi
authors: Adam J
authors: AJ
authors: Saenz
authors: Stephen E
authors: SE
authors: Fleming
authors: Julie
authors: J
authors: Teruya-Feldstein
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000378:metabolism; D018572:Disease-Free Survival; D005260:Female; D006391:Hemangioma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism; D008875:Middle Aged; D010950:Plasma Cells / Q000378:metabolism / Q000473:pathology; D049268:Positron-Emission Tomography; D011859:Radiography; D012598:Sclerosis; D013154:Spleen / Q000098:blood supply* / Q000000981:diagnostic imaging; D013156:Splenectomy; D013160:Splenic Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery
chemical_list: D015415:Biomarkers; D007074:Immunoglobulin G