Downsizing of enzymes by chemical methods: arginine mimics with low pKa values increase the rates of hydrolysis of RNA model compounds.
Lindgren
N Johan V
NJ
Department of Biochemistry and Organic Chemistry, Uppsala University, Box 576, 75123 Uppsala, Sweden.
Geiger
Lars
L
Razkin
Jesus
J
Schmuck
Carsten
C
Baltzer
Lars
L
D000595:Amino Acid Sequence; D001120:Arginine / Q000737:chemistry*; D020134:Catalytic Domain; D004798:Enzymes / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D008954:Models, Biological; D018716:Molecular Mimicry; D008969:Molecular Sequence Data; D015394:Molecular Structure; D012313:RNA / Q000737:chemistry*
D004798:Enzymes; D012313:RNA; D001120:Arginine