[Effective treatment of arterial hypertension in women reduces frequency of calls for medical aid due to emergency indications. Data from the AFINA study].
Results of the study of efficacy of 12 weeks antihypertensive therapy of women with uncontrolled arterial hypertension (AH) in ambulatory conditions are presented. It has been shown that therapy comprising controlled release indapamide allows to achieve greater lowering of arterial pressure (AP) as well as higher frequency of its target level (55%) compared with ordinary treatment (37%, p<0.001), adjusted odds ratio (OR) 2.05 (1.69-2.48). As a result in the indapamide group compared with the group of ordinary therapy we noted reduction of calls for medical aid because of urgent indications (OR 0.56 95% confidence interval 0.40-0.78). Analysis of subgroups has shown that minimal rate of such calls was noted in the group of patients in whom AP was lowered to target level irrespective of selected tactics of treatment. Thus inclusion of controlled release indapamide in therapy of women with AH compared with ordinary tactics of treatment allows to achieve better antihypertensive effect and to reduce frequency of calls for medical aid because of urgent indications.
Glezer
M G
MG
Saĭgitov
R T
RT
D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D003692:Delayed-Action Preparations; D004359:Drug Therapy, Combination; D004632:Emergency Medical Services / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D007190:Indapamide / Q000627:therapeutic use; D008875:Middle Aged
D000959:Antihypertensive Agents; D003692:Delayed-Action Preparations; D007190:Indapamide