Hypertriglyceridemia: an independent risk factor of chronic kidney disease in Taiwanese adults.
BACKGROUND
The prevalence and incidence of chronic kidney disease (CKD) are relatively high in Taiwanese patients than in patients of other countries, particularly in the older age groups. Dyslipidemia in patients with CKD has been recognized as a risk factor for disease progression but the role of triglycerides (TGs) remains controversial. With this regard, we evaluated the effects of hypertriglyceridemia on renal function in Taiwanese adults (aged >or=40 years).


METHODS
From January 2002 to December 2006, we conducted a community-based medical screening program in Chiayi County with 18,422 subjects (aged >or=40 years). The CKD was defined as an estimated glomerular filtration rate of <60 mL min 1.73 m. Age, body mass index, systolic blood pressure, fasting plasma glucose, and serum total cholesterol were considered as potential confounders.


RESULTS
The CKD was prevalent in 24.2% of the middle-aged and elderly population. By using multiple logistic regression models, we determined that old age and elevated levels of body mass index, systolic blood pressure, fasting plasma glucose, and cholesterol were associated with CKD. The adjusted odds ratios of CKD in participants with serum TG >==200 mg/dL was 1.901 (95% confidence interval: 1.07-3.36; P < 0.05) and in participants with serum TG > 500 mg/dL it increased to 2.205 (1.33-3.64, P < 0.05).


CONCLUSIONS
Hypertriglyceridemia is an independent risk factor for CKD in Taiwanese adults. Thus, an effective screening program that identifies people with hypertriglyceridemia is warranted.
Lee
Pei-Hsien
PH
Department of Nephrology, Chang Gung Memorial Hospital, Pu-tzu City, Chiayi, Taiwan.
Chang
Hung-Yu
HY
Tung
Chun-Wu
CW
Hsu
Yung-Chien
YC
Lei
Chen-Chou
CC
Chang
Hsun-Hao
HH
Yang
Hsueh-Fang
HF
Lu
Long-Chuan
LC
Jong
Ming-Chung
MC
Chen
Chiu-Yueh
CY
Fang
Kuei-Ying
KY
Chao
Yu-Shiu
YS
Shih
Ya-Hsueh
YH
Lin
Chun-Liang
CL
D000368:Aged; D002908:Chronic Disease; D005260:Female; D006801:Humans; D015228:Hypertriglyceridemia / Q000150:complications*; D015994:Incidence; D007674:Kidney Diseases / Q000453:epidemiology* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D013624:Taiwan / Q000453:epidemiology