Citral inhibits cell proliferation and induces apoptosis and cell cycle arrest in MCF-7 cells.
Many natural components of plants extract are studied for their beneficial effects on health and particularly on carcinogenesis chemoprevention. In this study, we investigated the effect of citral (3,7-dimethyl-2,6-octadienal), a key component of essential oils extracted from several herbal plants, on the proliferation rate, cell cycle distribution, and apoptosis of the human breast cancer cell line MCF-7. The effects of this compound were also tested on cyclo-oxygenase activity. Citral treatment caused inhibition of MCF-7 cell growth (IC(50)-48 h: 18 x 10(-5)m), with a cycle arrest in G(2)/M phase and apoptosis induction. Moreover, we observed a decrease in prostaglandin E(2) synthesis 48 h after citral treatment. These findings suggest that citral has a potential chemopreventive effect.
Chaouki
Wahid
W
Service of Laboratory, National Institute for Oncology, Rabat, Morocco.
Leger
David Y
DY
Liagre
Bertrand
B
Beneytout
Jean-Louis
JL
Hmamouchi
Mohamed
M
D000080462:Acyclic Monoterpenes; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D018929:Cell Culture Techniques; D002453:Cell Cycle / Q000187:drug effects*; D045744:Cell Line, Tumor; D002467:Cell Nucleus / Q000187:drug effects / Q000473:pathology; D049109:Cell Proliferation / Q000187:drug effects*; D051546:Cyclooxygenase 2 / Q000096:biosynthesis; D053938:DNA Fragmentation / Q000187:drug effects; D015232:Dinoprostone / Q000096:biosynthesis; D004305:Dose-Response Relationship, Drug; D006801:Humans; D039821:Monoterpenes / Q000494:pharmacology*; D012044:Regression Analysis; D013997:Time Factors
D000080462:Acyclic Monoterpenes; D016588:Anticarcinogenic Agents; D039821:Monoterpenes; D051546:Cyclooxygenase 2; D015232:Dinoprostone; C007076:citral