title: Topical application of solubilized Reseda luteola extract reduces ultraviolet B-induced inflammation in vivo.
abstract: We investigated the skin tolerance and anti-inflammatory potential of a nanoparticular solubilisate of a luteolin-rich Reseda extract (s-RE) in two independent studies in vivo. Reseda luteola extract containing 40% flavonoids was solubilized with polysorbate, resulting in product micelles with a diameter of 10 (+/-1.5)nm. Standardized inflammation was induced by irradiating test areas on the back of healthy volunteers with defined doses of ultraviolet B (UVB). In the first study different concentrations of s-RE were tested in 10 volunteers to evaluate dose-dependency of anti-inflammatory effects of s-RE. In the second randomized, double-blind, placebo-controlled study a defined concentration of s-RE (2.5%w/w) was tested in 40 volunteers in comparison to the vehicle (glycerol) and hydrocortisone (1%w/w). s-RE dose-dependently reduced UVB-induced erythema when applied 30 min before irradiation. To a lesser extent, topical application of s-RE after irradiation also reduced UVB-induced erythema. s-RE was as effective as hydrocortisone, whereas the vehicle had no effect. Occlusive application of s-RE on non-irradiated test sites did not cause any skin irritation. Due to excellent skin tolerance combined with potent anti-inflammatory properties s-RE bears potential especially for the prevention but also for the treatment of inflammatory skin conditions such as UV-induced erythema.
authors: Competence Center skintegral, University Medical Center Freiburg, Germany.
authors: F
authors: F
authors: Casetti
authors: W
authors: W
authors: Jung
authors: U
authors: U
authors: Wölfle
authors: J
authors: J
authors: Reuter
authors: K
authors: K
authors: Neumann
authors: B
authors: B
authors: Gilb
authors: A
authors: A
authors: Wähling
authors: S
authors: S
authors: Wagner
authors: I
authors: I
authors: Merfort
authors: C M
authors: CM
authors: Schempp
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D004311:Double-Blind Method; D004890:Erythema / Q000188:drug therapy*; D005260:Female; D005990:Glycerol / Q000494:pharmacology; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology; D047311:Luteolin / Q000737:chemistry / Q000494:pharmacology; D008297:Male; D010936:Plant Extracts / Q000627:therapeutic use*; D031951:Resedaceae / Q000737:chemistry*; D012867:Skin / Q000528:radiation effects*; D014466:Ultraviolet Rays
chemical_list: D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D047311:Luteolin; D005990:Glycerol; D006854:Hydrocortisone