title: The analysis of tear meniscus in soft contact lens wearers by spectral optical coherence tomography.
abstract: OBJECTIVE
  To evaluate the changes of tear meniscus in eyes fitted with soft contact lens (SCL) by spectral optical coherence tomography (SOCT).
  
  
  METHODS
  Thirty-three contact lens wearers who wore daily-wear frequent-replacement SCL with 55% water content for more than 6 years on average, and 33 normal subjects were enrolled in this study. The meniscus at the central lower lid of the left eye was examined by SOCT. For the lens wearers, the examination was performed twice: once with contact lens and once without. For the non-lens wearers, the examination was performed only once. The image of lower tear meniscus was divided into two parts: the hyperreflective curved layer (P1) and the hyporeflective triangular area (P2). The height of P1 and P2 (H-P1 and H-P2) was measured, along with the thickness and area of both parts (T-[P1+P2] and A-[P1+P2]).
  
  
  RESULTS
  The cornea, lower eyelid, contact lens, and the lower tear meniscus could be clearly visualized in the SOCT images. For the lens wearers, the mean values of H-P1, H-P2, T-[P1+P2], and A-[P1+P2] measured before removing the lenses were 164.18 +/- 41.77 microm, 148.6 +/- 42.84 microm, 134.72 +/- 38.39 microm, and 9914 +/- 469 microm. The values of these parameters measured after lens removal showed no significant differences from those measured with the lens. Variables tested in lens-wearers with and without contact lenses were both significantly lower than those of normal subjects.
  
  
  CONCLUSIONS
  SOCT can be helpful in evaluation of the lower tear meniscus in the eye fitted with a SCL. Long-term SCL wear could induce decreased tear volume, especially by reduction of the aqueous component.
authors: Department of Ophthalmology, Eye & ENT Hospital of Fudan University, Shanghai, China.
authors: Qihua
authors: Q
authors: Le
authors: Chunhui
authors: C
authors: Jiang
authors: Alice C
authors: AC
authors: Jiang
authors: Jianjiang
authors: J
authors: Xu
mesh_terms: D000328:Adult; D003263:Contact Lenses, Hydrophilic / Q000009:adverse effects; D020878:Device Removal; D005143:Eyelids / Q000378:metabolism; D005260:Female; D005583:Fourier Analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D013666:Tears / Q000378:metabolism*; D041623:Tomography, Optical Coherence / Q000379:methods*; D055815:Young Adult