Transient receptor potential channels on sensory nerves.
The somatosensory effects of natural products such as capsaicin, mustard oil, and menthol have been long recognized. Over the last decade, the identification of transient receptor potential (TRP) channels in primary sensory neurons as the targets for these agents has led to an explosion of research into the roles of "thermoTRPs" TRPV1, TRPV2, TRPV3, TRPV4, TRPA1, and TRPM8 in nociception. In concert, through the efforts of many industrial and academic teams, a number of agonists and antagonists of these channels have been discovered, paving the way for a better understanding of sensory biology and, potentially, for novel treatments for diseases.
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Department of Pain Research, Neuroscience Drug Discovery, Merck Research Laboratories, West Point, Philadelphia, USA. samer_eid@merck.com
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D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D006801:Humans; D010146:Pain / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology; D017288:Pain Threshold; D011984:Sensory Receptor Cells / Q000187:drug effects / Q000378:metabolism*; D050053:TRPM Cation Channels / Q000378:metabolism; D050916:TRPV Cation Channels / Q000378:metabolism; D050051:Transient Receptor Potential Channels / Q000187:drug effects / Q000378:metabolism*
D000700:Analgesics; D050053:TRPM Cation Channels; D050916:TRPV Cation Channels; D050051:Transient Receptor Potential Channels