title: Replicate single-use comparative study of plaque removal with two contemporary manual toothbrushes.
abstract: OBJECTIVE
  To compare the plaque removing efficacy of Oral-B Advantage 123 and Colgate 360 degrees manual toothbrushes on a single brushing after a 24-hour void in oral hygiene.
  
  
  METHODS
  This study had a two-treatment (Advantage 123 versus Colgate 360 degrees), examiner-blind, randomized, four-period (visit) crossover design. At the first (baseline) visit, subjects received a plaque examination using the Rustogi Modified Navy Plaque Index (RMNPI) after which they were instructed to brush for 1 minute in their normal manner with their assigned toothbrush and a marketed dentifrice and unaided by access to a mirror. Post-brushing plaque was then assessed. At three further visits, each separated by a period of 3-8 days, brushes were assigned to subjects according to their treatment sequence and the same brushing and plaque grading procedure as at baseline was followed.
  
  
  RESULTS
  50 subjects were enrolled in the replicate single-use study; all were included in the analysis. Oral-B Advantage 123 was significantly better than Colgate 360 degrees at reducing whole mouth (P = 0.006), gingival margin (P = 0.010) and approximal (P = 0.040) plaque scores.
authors: University of Texas Health Science Center, San Antonio Dental School, USA.
authors: Giza T
authors: GT
authors: Terézhalmy
authors: Pat
authors: P
authors: Walters
authors: Robert D
authors: RD
authors: Bartizek
authors: Julie M
authors: JM
authors: Grender
authors: Aaron R
authors: AR
authors: Biesbrock
mesh_terms: D000328:Adult; D000368:Aged; D018592:Cross-Over Studies; D003742:Dental Devices, Home Care; D003773:Dental Plaque / Q000628:therapy*; D003774:Dental Plaque Index; D004209:Disposable Equipment; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D016037:Single-Blind Method; D014099:Toothbrushing / Q000295:instrumentation*; D055815:Young Adult