title: Touch imprint cytological diagnosis of nodal Langerhans cell histiocytosis.
abstract: Touch imprint cytological diagnosis of nodal Langerhans cell histiocytosis. Langerhans cell histiocytosis (LCH) is a rare neoplasm of the mononuclear phagocytic immunoregulatory system of unknown aetiology. Nodal involvement is uncommon. Cytological findings have seldom been described. A case study of LCH, arising in a submandibular node of a 42-year-old female, is reported. Fine needle aspiration smears were highly cellular and composed of a mixed cell population including eosinophils, lymphocytes, neutrophils, and macrophages. Imprint slides from the surgical specimen of the excised node exhibited Langerhans cells with nuclear grooves, leading to a diagnosis suggestive of LCH. Immunohistochemical staining of the node sections with CD1a and S-100 confirmed this diagnosis. In conclusion, cytology may favorably contribute to the diagnosis of LCH.
authors: Department of Cytopathology, General Hospital of Chania, Crete, Greece.
authors: D
authors: D
authors: Tamiolakis
authors: S
authors: S
authors: Barbagadaki
authors: E
authors: E
authors: Proimos
authors: S
authors: S
authors: Nikolaidou
authors: T S
authors: TS
authors: Chimona
authors: G
authors: G
authors: Georgiou
authors: G
authors: G
authors: Perogamvrakis
authors: C E
authors: CE
authors: Papadakis
mesh_terms: D000328:Adult; D003581:Cytodiagnosis; D005260:Female; D006646:Histiocytosis, Langerhans-Cell / Q000473:pathology*; D006801:Humans; D008198:Lymph Nodes; D008334:Mandible