Regulation of intestinal iron absorption: the mucosa takes control?
Two studies (Shah et al., 2009; Mastrogiannaki et al., 2009) show that the hypoxia inducible factor HIF-2alpha is a major player in regulating iron absorption by directly controlling the transcription of iron transporters in the intestine in response to changes in mucosal iron or oxygen levels. The HIF-2alpha mechanism has major effects on iron metabolism which can override the well-known hepcidin-ferroportin regulatory axis.
Simpson
Robert J
RJ
Kings College London, Division of Nutritional Sciences, London, UK.
McKie
Andrew T
AT
D000818:Animals; D023181:Antimicrobial Cationic Peptides / Q000378:metabolism; D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics / Q000378:metabolism; D027682:Cation Transport Proteins / Q000378:metabolism; D064451:Hepcidins; D051793:Hypoxia-Inducible Factor 1 / Q000235:genetics / Q000378:metabolism; D007408:Intestinal Absorption; D007413:Intestinal Mucosa / Q000502:physiology*; D007501:Iron / Q000378:metabolism*; D051379:Mice; D000098742:Ferroportin; D000099162:Endothelial PAS Domain-Containing Protein 1
D023181:Antimicrobial Cationic Peptides; D051792:Basic Helix-Loop-Helix Proteins; D027682:Cation Transport Proteins; D064451:Hepcidins; D051793:Hypoxia-Inducible Factor 1; D007501:Iron; D000098742:Ferroportin; D000099162:Endothelial PAS Domain-Containing Protein 1; C579599:Hamp protein, mouse