title: Construction noise decreases reproductive efficiency in mice.
abstract: Excessive noise is well known to impair rodent health. To better understand the effect of construction noise and to establish effective noise limits during a planned expansion of our vivarium, we analyzed the effects of construction noise on mouse gestation and neonatal growth. Our hypothesis was that high levels of construction noise would reduce the number of live births and retard neonatal growth. Female Swiss Webster mice were individually implanted with 15 B6CBAF1/J embryos and then exposed to 70- and 90-dBA concrete saw cutting noise samples at defined time points during gestation. In addition, groups of mice with litters were exposed to noise at 70, 80, or 90 dBA for 1 h daily during the first week after parturition. Litter size, birth weight, incidence of stillborn pups, and rate of neonatal weight gain were analyzed. Noise decreased reproductive efficiency by decreasing live birth rates and increasing the number of stillborn pups.
authors: The Comparative Bioscience Center, The Rockefeller University, New York, New York; The Tri-Institutional Training Program for Laboratory Animal Medicine and Science, New York, New York. rasmusss@mskcc.org
authors: Skye
authors: S
authors: Rasmussen
authors: Gary
authors: G
authors: Glickman
authors: Rada
authors: R
authors: Norinsky
authors: Fred W
authors: FW
authors: Quimby
authors: Ravi J
authors: RJ
authors: Tolwani
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000502:physiology; D004624:Embryo Transfer; D005160:Facility Design and Construction; D005260:Female; D015994:Incidence; D008098:Litter Size / Q000502:physiology; D051379:Mice; D009623:Noise, Occupational / Q000009:adverse effects*; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000502:physiology*; D012098:Reproduction / Q000502:physiology*; D050497:Stillbirth / Q000453:epidemiology