title: Urinary soluble egg antigen levels in Schistosoma haematobium infection in relation to sex and age of Kenyan schoolchildren following praziquantel treatment.
abstract: Schistosoma haematobium soluble egg antigen (SEA) secreted in urine can be assayed to determine egg tissue load and hence morbidity in infected individuals. A cohort of 158 infected children aged 4-18 years was followed-up for 33 days pre and post treatment with a single dose of praziquantel. There was a significant difference in the prevalence of S. haematobium between males and females (P < 0.05). There were also significant differences in egg counts between age group < or = 5 years compared with 6-8 years, 9-11 years and 12-14 years, and age group > or = 15 years compared with 6-8 years, 9-11 years and 12-14 years (P < 0.05). Comparison of SEA among age groups indicated a significant difference between age group < or = 5 years compared with 9-11 years, 12-14 years and > or = 15 years, and age group > or = 15 years compared with 9-11 years and 12-14 years (P < 0.05). There was a statistically significant correlation between levels of SEA and egg output (r2=0.961, P=0.010). These results are useful in the development of a SEA-based dipstick assay for field diagnosis of urinary schistosomiasis.
authors: Division of Vector Borne Diseases, Ministry of Health, P.O. Box 20750, 00202 Nairobi, Kenya. jkihara@kemri.org
authors: Jimmy H
authors: JH
authors: Kihara
authors: Eliud N M
authors: EN
authors: Njagi
authors: Eucharia U
authors: EU
authors: Kenya
authors: Marium T
authors: MT
authors: Mwanje
authors: Adel E
authors: AE
authors: Odek
authors: Govert
authors: G
authors: van Dam
authors: Anthony I
authors: AI
authors: Kahama
authors: John H
authors: JH
authors: Ouma
mesh_terms: D000293:Adolescent; D000367:Age Factors; D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D000947:Antigens, Helminth / Q000652:urine*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007630:Kenya / Q000453:epidemiology; D008297:Male; D010270:Parasite Egg Count; D011223:Praziquantel / Q000627:therapeutic use*; D012548:Schistosoma haematobium / Q000276:immunology*; D012553:Schistosomiasis haematobia / Q000188:drug therapy / Q000453:epidemiology / Q000652:urine*; D012737:Sex Factors; D013334:Students
chemical_list: D000871:Anthelmintics; D000947:Antigens, Helminth; D011223:Praziquantel