title: Erosive mucosal lichen planus and secondary epiphora responding to systemic cyclosporin A treatment.
abstract: Erosive mucosal lichen planus (LP) is a well-established variant of LP characterized by the formation of ulcerative lesions predominantly involving the oral and genital mucosae. Less commonly, this condition may involve oesophageal and/or ocular mucosal surfaces, and case reports within the ophthalmology literature have recently confirmed the potential for this condition to affect the nasolacrimal ducts. We report the case of a woman with severe cicatrizing mucosal LP and ocular symptoms secondary to presumed nasolacrimal duct involvement. We also report the potential for this newly appreciated manifestation of LP to respond to systemic cyclosporin A.
authors: Flinders Medical Centre, Adelaide, South Australia, Australia.
authors: Aaron E
authors: AE
authors: Boyce
authors: Gillian
authors: G
authors: Marshman
authors: Richard A D
authors: RA
authors: Mills
mesh_terms: D001707:Biopsy, Needle; D016572:Cyclosporine / Q000008:administration & dosage*; D018450:Disease Progression; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D007766:Lacrimal Apparatus Diseases / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D008010:Lichen Planus / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D017676:Lichen Planus, Oral / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy; D008875:Middle Aged; D009061:Mouth Mucosa / Q000187:drug effects / Q000473:pathology; D012720:Severity of Illness Index; D016896:Treatment Outcome; D014845:Vulvar Diseases / Q000150:complications / Q000188:drug therapy* / Q000473:pathology
chemical_list: D016572:Cyclosporine