[Xanthine oxidase activity in transplantable Guerin's carcinoma in rats].
Influence of low-dosage pre-irradiation on xanthine oxidase levels in Guerin's carcinoma was studied with particular emphasis on free oxygen generation and free sulphohydrils in a fraction of proteins characterized by xanthine oxidase activity. Enhanced growth of tumor correlated with that of xanthine oxidase activity involving higher levels of enzymatic O-form due to thiol groups oxidation. Under similar conditions, xanthine oxidase and free oxygen generation levels were higher due to SH-group oxidation than in intact animals. Terminal stages involved dropping xanthine oxidase levels and enzymatic protein degradation.
Shmarakov
I A
IA
Marchenko
M M
MM
D000818:Animals; D005260:Female; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000201:enzymology* / Q000378:metabolism / Q000473:pathology; D011489:Protein Denaturation; D051381:Rats; D017382:Reactive Oxygen Species / Q000378:metabolism; D013438:Sulfhydryl Compounds / Q000378:metabolism; D014969:Xanthine Oxidase / Q000378:metabolism*
D017382:Reactive Oxygen Species; D013438:Sulfhydryl Compounds; D014969:Xanthine Oxidase