Gombapyrones, new alpha-pyrone metabolites produced by Streptomyces griseoruber Acta 3662.
Gombapyrones A-D, new members of the alpha-pyrone family of secondary metabolites, were produced by Streptomyces griseoruber Acta 3662, which was isolated from bamboo tree rhizosphere. The strain was characterized by its morphological and chemotaxonomical features and by 16S rDNA sequencing as S. griseobuber. The gombapyrone structures were determined by mass spectrometry and by NMR experiments, and were found to have an inhibitory activity against protein tyrosine phosphatase 1B and glycogen synthase kinase 3beta.
Helaly
Soleiman
S
Institut für Chemie, Technische Universität Berlin, Berlin, Germany.
Schneider
Kathrin
K
Nachtigall
Jonny
J
Vikineswary
Sabaratnam
S
Tan
Geok Yuan Annie
GY
Zinecker
Heidi
H
Imhoff
Johannes F
JF
Süssmuth
Roderich D
RD
Fiedler
Hans-Peter
HP
D001419:Bacteria / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D003470:Culture Media; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology; D005285:Fermentation; D038362:Glycogen Synthase Kinase 3 / Q000037:antagonists & inhibitors; D000071679:Glycogen Synthase Kinase 3 beta; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D025282:Mycelium / Q000254:growth & development / Q000378:metabolism; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1 / Q000037:antagonists & inhibitors; D011753:Pyrones / Q000737:chemistry / Q000494:pharmacology; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D013302:Streptomyces / Q000737:chemistry / Q000145:classification / Q000378:metabolism*
D003470:Culture Media; D004791:Enzyme Inhibitors; D011753:Pyrones; D000071679:Glycogen Synthase Kinase 3 beta; D038362:Glycogen Synthase Kinase 3; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1