title: Impact of sentinel lymph node biopsy on immediate breast reconstruction after mastectomy.
abstract: Traditionally, sentinel lymph node biopsy (SLNB) is performed at the time of mastectomy and reconstruction. However, several groups have advocated SLNB as a separate outpatient procedure before mastectomy, when immediate reconstruction is planned, to allow for complete pathologic evaluation. The purpose of this study was to determine the impact of intraoperative analysis of SLNB on the reconstructive plan when performed at the same time as definitive surgery. A retrospective review was conducted of all mastectomy cases performed at a single institution between September 1998 and November 2007. Of the 747 mastectomy cases reviewed, SLNB was conducted in 344 cases, and there was immediate breast reconstruction in 193 of those cases. There were 27 (7.8%) false negative and three (0.9%) false positive intraoperative analysis of SLNB. Touch preparation analysis from the SLNB changed the reconstructive plan in four (2.1%) cases. In our experience, SLNB can be performed at the time of mastectomy with minimal impact on the reconstructive plan. A staged approach incurs significant additional expense, increases the delay in initiation of systemic therapy and the propensity of procedure-related morbidity; therefore, SLNB should not be performed as a separate procedure before definitive surgery with immediate breast reconstruction.
authors: Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA.
authors: Benjamin C
authors: BC
authors: Wood
authors: Lisa R
authors: LR
authors: David
authors: Anthony J
authors: AJ
authors: Defranzo
authors: John H
authors: JH
authors: Stewart
authors: Perry
authors: P
authors: Shen
authors: Kim R
authors: KR
authors: Geisinger
authors: Malcolm W
authors: MW
authors: Marks
authors: Edward A
authors: EA
authors: Levine
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology* / Q000601:surgery*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000473:pathology* / Q000601:surgery*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007430:Intraoperative Care; D008297:Male; D016462:Mammaplasty; D008408:Mastectomy; D008875:Middle Aged; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D021701:Sentinel Lymph Node Biopsy; D055815:Young Adult