title: Hippocampal protein levels related to spatial memory are different in the Barnes maze and in the multiple T-maze.
abstract: The Multiple T-maze (MTM) and the Barnes maze (BM) are land mazes used for the evaluation of spatial memory. The observation that mice are performing differently in individual mazes made us test the hypothesis that differences in cognitive performances in the two land mazes would be accompanied by differences in hippocampal protein levels. C57BL/6J mice were tested in the BM and in the MTM, hippocampi were extirpated 6 h following the probe trials each, and proteins were extracted for gel-based proteomic analysis. Mice learned the task in both paradigms. Levels of hippocampal proteins from several pathways including signaling, chaperone, and metabolic cascades were significantly different between the two spatial memory tasks. Protein levels were linked to spatial memory specifically as yoked controls were used.
authors: Department of Pediatrics, Medical University of Vienna, Vienna, Austria.
authors: Jun-Fang
authors: JF
authors: Zheng
authors: Sudarshan S
authors: SS
authors: Patil
authors: Wei-Qiang
authors: WQ
authors: Chen
authors: Wei
authors: W
authors: An
authors: Jun-Qi
authors: JQ
authors: He
authors: Harald
authors: H
authors: Höger
authors: Gert
authors: G
authors: Lubec
mesh_terms: D000818:Animals; D019703:Calcineurin / Q000378:metabolism; D015180:Electrophoresis, Gel, Two-Dimensional; D006624:Hippocampus / Q000737:chemistry / Q000378:metabolism*; D008297:Male; D018782:Maze Learning / Q000502:physiology*; D008568:Memory / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D011506:Proteins / Q000378:metabolism; D040901:Proteomics / Q000379:methods*; D015398:Signal Transduction / Q000502:physiology*; D013028:Space Perception / Q000502:physiology; D018709:Statistics, Nonparametric
chemical_list: D011506:Proteins; D019703:Calcineurin