T cells in mycobacterial infection and disease.
There has been an increase in our understanding of the complexity of the T cell response to mycobacterial infection recently. Improved tools have allowed the determination of the location and kinetics of naïve T cell activation in the mouse as well the variety of function of mycobacteria-specific cells in humans. There is also an increased appreciation of the balance required during mycobacterial infection between anti-bacterial activity and control of the immunopathologic response. The integration of the T cell functional data with the consequences of infection should improve rational vaccine design.
Cooper
Andrea M
AM
The Trudeau Institute, Inc., Saranac Lake, NY 12983, USA. acooper@trudeauinstitute.org
D000818:Animals; D016207:Cytokines / Q000276:immunology; D006801:Humans; D008168:Lung / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D051379:Mice; D009169:Mycobacterium tuberculosis / Q000254:growth & development / Q000276:immunology* / Q000472:pathogenicity; D010586:Phagocytes / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D016176:T-Lymphocyte Subsets / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D032581:Tuberculosis Vaccines / Q000627:therapeutic use; D014397:Tuberculosis, Pulmonary / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D014774:Virulence
D016207:Cytokines; D032581:Tuberculosis Vaccines