Transient News Events Test: feasibility in assessment of post-temporal lobectomy remote memory deficits.
Although anterograde memory deficits are well documented in patients with epilepsy, the extent to which remote memory deficits occur is less clear. This is due in part to a lack of reliable methods for assessment. The present study examined the feasibility of using the Transient News Events Test (TNET) to assess remote memory in subjects status post anterior temporal lobectomy (ATL) for the treatment of refractory seizures. Results indicated significantly poorer performance of the patient group compared to healthy controls. The decrement in performance within the patient group was evident only for items from more recent time periods. Reasons for an apparent stability of the most remote memories with ATL and implications regarding hippocampal function are reviewed. In conclusion, the TNET provides a feasible method for assessment of remote memory function in patients with epilepsy, with decrements in performance noted in comparison to a healthy control group in this retrospective study.
Leeman
Beth A
BA
Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. bleeman1@bidmc.harvard.edu
Macklin
Eric A
EA
Schomer
Donald L
DL
O'Connor
Margaret G
MG
D000328:Adult; D000367:Age Factors; D000704:Analysis of Variance; D004493:Education; D004833:Epilepsy, Temporal Lobe / Q000175:diagnosis / Q000523:psychology; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D020232:Kluver-Bucy Syndrome / Q000175:diagnosis* / Q000453:epidemiology / Q000523:psychology; D016014:Linear Models; D008297:Male; D008569:Memory Disorders / Q000175:diagnosis* / Q000209:etiology* / Q000523:psychology; D008570:Memory, Short-Term / Q000502:physiology; D008875:Middle Aged; D011183:Postoperative Complications / Q000175:diagnosis* / Q000453:epidemiology / Q000523:psychology; D011597:Psychomotor Performance / Q000502:physiology; D021641:Recognition, Psychology / Q000502:physiology; D012737:Sex Factors