title: The bioactive metabolites of the mangrove endophytic fungus Talaromyces sp. ZH-154 isolated from Kandelia candel (L.) Druce.
abstract: Bioactivity-directed fractionation of the extract of the mangrove endophytic fungus Talaromyces sp. ZH-154, which was isolated from the stem bark of Kandelia candel (L.) Druce, Rhizophoraceae, afforded two new metabolites, 7-epiaustdiol ( 1) and 8-O-methylepiaustdiol ( 2), together with the known compounds, stemphyperylenol ( 3), skyrin ( 4), secalonic acid A ( 5), emodin ( 6), and norlichexanthone ( 7). Their structures were elucidated on the basis of spectroscopic evidences including CD, MS, and 1D, 2D NMR techniques. The absolute configuration of 1 was unequivocally determined by single-crystal X-ray diffraction. All isolated compounds were evaluated for their antimicrobial and in vitro cytotoxic activities.
authors: School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou, China.
authors: Fan
authors: F
authors: Liu
authors: Xiao-Ling
authors: XL
authors: Cai
authors: Hong
authors: H
authors: Yang
authors: Xue-Kui
authors: XK
authors: Xia
authors: Zhi-Yong
authors: ZY
authors: Guo
authors: Jie
authors: J
authors: Yuan
authors: Meng-Feng
authors: MF
authors: Li
authors: Zhi-Gang
authors: ZG
authors: She
authors: Yong-Cheng
authors: YC
authors: Lin
mesh_terms: D000873:Anthracenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001578:Benzopyrans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor / Q000187:drug effects; D018360:Crystallography, X-Ray; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D038821:Mycorrhizae / Q000378:metabolism; D024301:Plant Bark; D018547:Plant Stems; D043982:Rhizophoraceae / Q000737:chemistry*; D032901:Talaromyces / Q000378:metabolism*; D014961:X-Ray Diffraction
chemical_list: C549462:7-epiaustdiol; C549463:8-O-methylepiaustdiol; D000873:Anthracenes; D000970:Antineoplastic Agents; D001578:Benzopyrans