title: HLA class I and II polymorphisms in Mexican Mestizo patients with dengue fever.
abstract: Host genetics in dengue hemorrhagic fever (DHF) pathophysiology has not been extensively investigated. Most studies have focused on HLA in different populations; however these reported associations have not been replicated. We performed a case-control study to analyze possible associations of HLA-A, HLA-B, HLA-Cw, HLA-DRB1 and HLA-DQB1 alleles with clinical disease severity caused by dengue virus infection. Our population consisted of 39 individuals (DF: 23, DHF: 16) and 34 healthy controls from the State of Morelos, Mexico. HLA loci were genotyped by nucleotide sequencing method. Statistical analyses revealed associations in three alleles: HLA-B*35 was negatively associated with symptomatic disease (p<1x10(-4), p(c)=0.01, OR=0.12, 95%CI=0.037-0.39), and DF (p=0.0007, p(c)=0.03, OR=0.13, 95%CI=0.031-0.51). HLA-DQB1*0302 was positively associated with DHF (p=0.018, p(c)=NS, OR=5.02, 95%CI=1.05-25.34), and negatively with DF (p=0.011, p(c)=NS, OR=0.23, 95%CI=0.06-0.84). HLA-DQB1*0202 was positively associated with DF only (p=0.012, p(c)=NS, OR=7.0, 95%CI=1.11-73.8). We identified possible associations of HLA-B and HLA-DQB1 alleles with the risk of developing symptomatic disease, DF and DHF in a Mexican Mestizo population.
authors: Arboviruses Department, Center for Research in Infectious Diseases, National Institute of Public Health, Cuernavaca, Morelos, Mexico.
authors: Jorge Abelardo
authors: JA
authors: Falcón-Lezama
authors: Celso
authors: C
authors: Ramos
authors: Joaquín
authors: J
authors: Zuñiga
authors: Lilia
authors: L
authors: Juárez-Palma
authors: Hilda
authors: H
authors: Rangel-Flores
authors: Alma Rosa
authors: AR
authors: García-Trejo
authors: Victor
authors: V
authors: Acunha-Alonzo
authors: Julio
authors: J
authors: Granados
authors: Gilberto
authors: G
authors: Vargas-Alarcón
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D003715:Dengue / Q000235:genetics* / Q000276:immunology / Q000473:pathology*; D005260:Female; D005787:Gene Frequency; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006801:Humans; D008297:Male; D008800:Mexico; D008875:Middle Aged; D011110:Polymorphism, Genetic; D017422:Sequence Analysis, DNA; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II