MicroRNAs in common diseases and potential therapeutic applications.
1. Evidence gathered in recent years has revealed microRNAs (miRNAs) fine-tune gene expression and play an important role in various cellular processes, including cell growth, differentiation, proliferation and apoptosis. 2. The present review summarizes current knowledge of miRNA pathways in the pathogenesis of cancer, cardiac diseases, neurodegenerative diseases, diabetes, autoimmune/inflammatory diseases and infection. 3. There is considerable potential to target miRNAs as a novel approach in the treatment of human diseases. Currently, miRNA-based therapies are being examined in both animal models and human clinical trials.
Tsai
Louis M
LM
Immunology and Inflammation Research Program, Garvan Institute of Medical Research, Sydney, New South Wales, Australia.
Yu
Di
D
D000818:Animals; D001327:Autoimmune Diseases / Q000235:genetics / Q000628:therapy; D003920:Diabetes Mellitus / Q000235:genetics / Q000628:therapy; D005786:Gene Expression Regulation; D015972:Gene Expression Regulation, Neoplastic; D015316:Genetic Therapy / Q000379:methods*; D006331:Heart Diseases / Q000235:genetics / Q000628:therapy; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism / Q000627:therapeutic use*; D008957:Models, Genetic; D009369:Neoplasms / Q000235:genetics / Q000628:therapy; D019636:Neurodegenerative Diseases / Q000235:genetics / Q000628:therapy; D034622:RNA Interference; D014777:Virus Diseases / Q000235:genetics / Q000628:therapy
D035683:MicroRNAs