A phase code for memory could arise from circuit mechanisms in entorhinal cortex.
Neurophysiological data reveals intrinsic cellular properties that suggest how entorhinal cortical neurons could code memory by the phase of their firing. Potential cellular mechanisms for this phase coding in models of entorhinal function are reviewed. This mechanism for phase coding provides a substrate for modeling the responses of entorhinal grid cells, as well as the replay of neural spiking activity during waking and sleep. Efforts to implement these abstract models in more detailed biophysical compartmental simulations raise specific issues that could be addressed in larger scale population models incorporating mechanisms of inhibition.
Hasselmo
Michael E
ME
Center for Memory and Brain, Department of Psychology and Program in Neuroscience, Boston University, 2 Cummington Street, Boston, MA 02215, USA. hasselmo@bu.edu
Brandon
Mark P
MP
Yoshida
Motoharu
M
Giocomo
Lisa M
LM
Heys
James G
JG
Fransen
Erik
E
Newman
Ehren L
EL
Zilli
Eric A
EA
D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D001683:Biological Clocks / Q000502:physiology; D018728:Entorhinal Cortex / Q000166:cytology / Q000502:physiology*; D006801:Humans; D008568:Memory / Q000502:physiology*; D008959:Models, Neurological; D009415:Nerve Net / Q000166:cytology / Q000502:physiology*; D009433:Neural Inhibition / Q000502:physiology; D009474:Neurons / Q000502:physiology*; D014851:Wakefulness / Q000502:physiology