title: [Changes in proinflammatory cytokine and destructive metalloproteinase levels during formation of unstable atherosclerotic plaque].
abstract: We studied men with coronary atherosclerosis without acute coronary syndrome and determined typical valuable parameters of inflammatory (tumor necrotic factor, antagonist of receptor to interleukin [IL] 1, IL 6, IL 8, monocytes chemotactic protein 1, endothelial monocytes activating protein II), and destructive (matrix metalloproteinase [MMP] 3, MMP 7, MMP 9, tissue inhibitor of metalloproteinase) processes at consecutive stages of formation of coronary atherosclerotic plaque: "normal intimal tissue --> lipid stain --> early stable plaque --> unstable vulnerable plaque <--> stable plaque with fibrosis", and in 3 types of unstable plaques (lipid type, inflammatory erosive type, necrotic type).
authors: Iu I
authors: IuI
authors: Ragino
authors: A M
authors: AM
authors: Cherniavskiĭ
authors: Ia V
authors: IaV
authors: Polonskaia
authors: A M
authors: AM
authors: Volkov
authors: E V
authors: EV
authors: Semaeva
authors: S Iu
authors: SIu
authors: Tsymbal
authors: M I
authors: MI
authors: Voevoda
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000378:metabolism; D003324:Coronary Artery Disease / Q000201:enzymology* / Q000378:metabolism* / Q000473:pathology; D003331:Coronary Vessels / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D016207:Cytokines / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D008297:Male; D045726:Metalloproteases / Q000378:metabolism*; D008875:Middle Aged; D009336:Necrosis; D017539:Tunica Intima / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D017540:Tunica Media / Q000201:enzymology / Q000378:metabolism / Q000473:pathology
chemical_list: D015415:Biomarkers; D016207:Cytokines; D045726:Metalloproteases