title: Comprehensive assessment of the severity and mechanism of aortic regurgitation using multidetector CT and MR.
abstract: Recent studies have suggested that both cardiac magnetic resonance (MR) and multidetector computed tomography (MDCT) can quantify aortic regurgitation (AR) by planimetry of the anatomical regurgitant orifice (ARO). However, this measurement was not compared with quantitative assessment of AR such as the effective regurgitant orifice (ERO) by proximal isosurface area (PISA) transthoracic echocardiography (TTE) or phase contrast MR. In 42 patients (34 men, age 54 +/- 11 years) we compared planimetered ARO by MDCT and MR with ERO and regurgitant volume by PISA TTE and phase contrast MR. ARO by MDCT (r = 0.87, p < 0.001) and MR (r = 0.81, p < 0.001) correlated highly with ERO by TTE. However, ARO by MDCT (27 +/- 15 mm(2), p < 0.001), but not by MR (23 +/- 13 mm(2), p = 0.58), were larger than PISA ERO (22 +/- 11 mm(2)). ARO by MDCT (r = 0.78, p < 0.001; r = 0.85, p < 0.001) and MR (r = 0.85, p < 0.001; r = 0.87 p < 0.001) correlated well with regurgitant volume by PISA and phase contrast MR. Both MDCT (small ka, Cyrillic = 0.80, p < 0.001) and MR (small ka, Cyrillic = 0.84, p < 0.001) demonstrated excellent agreement in correctly assessing the mechanisms of AR, i.e. aortic root dilatation (type I), cusp prolapse (type II) and restrictive cusp motion (type III), using surgical inspection as a reference. Measurement of ARO by both MDCT and MR allows accurate quantitative assessment of AR. Both techniques can also accurately determine the mechanism of AR.
authors: Cardiology Division, Cliniques Universitaires St. Luc UCL, Av Hippocrate 10/2806, 1200, Woluwe St. Lambert, Belgium.
authors: Céline
authors: C
authors: Goffinet
authors: Valérie
authors: V
authors: Kersten
authors: Anne-Catherine
authors: AC
authors: Pouleur
authors: Jean-Benoit
authors: JB
authors: le Polain de Waroux
authors: David
authors: D
authors: Vancraeynest
authors: Agnès
authors: A
authors: Pasquet
authors: Jean-Louis
authors: JL
authors: Vanoverschelde
authors: Bernhard L
authors: BL
authors: Gerber
mesh_terms: D000328:Adult; D000368:Aged; D001022:Aortic Valve Insufficiency / Q000175:diagnosis*; D001027:Aortography / Q000379:methods*; D005260:Female; D006801:Humans; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013382:Subtraction Technique; D014057:Tomography, X-Ray Computed / Q000379:methods*