title: Screening of polycyclic polyprenylated acylphloroglucinols from Garcinia species using precursor ion discovery (PID) scan and ultra performance liquid chromatography electrospray ionization Q-TOF tandem mass spectrometry.
abstract: A strategy was newly developed to rapidly screen polycyclic polyprenylated acyl-phloroglucinols (PPAPs) from the plant matrices of nine Garcinia species using ultra-performance liquid chromatography (UPLC) coupled with comprehensive mass spectrometric approaches including precursor ion discovery (PID) and tandem mass (MS/MS) scans. The PPAPs share the same diagnostic product ion at m/z 177.02 in positive MS/MS scan, which may be increased as the base peak by ramping the cone voltage from 45 to 100 V. With this ramping cone voltage PID scan, it is feasible to selectively screen the PPAPs from 29 samples of nine Garcinia species. This approach has proven to be a powerful, highly selective, and sensitive tool for rapid screening and detection of nontargeted components in natural products before the purification and structural elucidation process.
authors: Hong Kong Jockey Club Institute of Chinese Medicine, Hong Kong, China.
authors: Yan
authors: Y
authors: Zhou
authors: Sheng-Xiong
authors: SX
authors: Huang
authors: Jing-Zheng
authors: JZ
authors: Song
authors: Chun-Feng
authors: CF
authors: Qiao
authors: Song-Lin
authors: SL
authors: Li
authors: Quan-Bin
authors: QB
authors: Han
authors: Hong-Xi
authors: HX
authors: Xu
mesh_terms: D001577:Benzophenones / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D029760:Garcinia / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry*; D011083:Polycyclic Compounds / Q000737:chemistry*; D054876:Prenylation; D053719:Tandem Mass Spectrometry / Q000379:methods*; D013729:Terpenes / Q000737:chemistry
chemical_list: D001577:Benzophenones; D010936:Plant Extracts; D011083:Polycyclic Compounds; D013729:Terpenes