Organocatalytic asymmetric allylic alkylation of oxindoles with Morita-Baylis-Hillman carbonates.
The organic Lewis base-catalysed asymmetric allylic alkylation of 3-substituted oxindoles with Morita-Baylis-Hillman carbonates is reported, affording multifunctional oxindoles with adjacent quaternary and tertiary chiral centres (dr up to 92 : 8, 86-97% ee).
Jiang
Kun
K
Key Laboratory of Drug-Targeting and Drug Delivery System of Education Ministry, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, China.
Peng
Jing
J
Cui
Hai-Lei
HL
Chen
Ying-Chun
YC
D000478:Alkylation; D000498:Allyl Compounds / Q000737:chemistry*; D002254:Carbonates / Q000737:chemistry*; D002384:Catalysis; D002930:Cinchona Alkaloids / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry*; D015394:Molecular Structure; D000078183:Oxindoles; D013237:Stereoisomerism
D000498:Allyl Compounds; D002254:Carbonates; D002930:Cinchona Alkaloids; D007211:Indoles; D000078183:Oxindoles; C022960:2-oxindole