title: Carbocyclic 4'-Epiformycin.
abstract: Formycin is a naturally occurring biologically responsive C-nucleoside. In pursuing the design and syntheses of novel C-nucleosides, convenient access to carbocyclic C-nucleosides based on the formycin framework was a goal. One such target was carbocyclic 4'-epiformycin (4). This compound is reported via a procedure based on an asymmetric aldol/ring closure methathesis strategy. To provide a preliminary glimpse into the biological characterization of 4 an antiviral assay was conducted. Target 4 was found to be inactive and to lack cytotoxicity to the host cells.
authors: Department of Chemistry and Biochemistry, Auburn University, Auburn, Alabama 36849-5312.
authors: Jian
authors: J
authors: Zhou
authors: Minmin
authors: M
authors: Yang
authors: Akin
authors: A
authors: Akdag
authors: Haisheng
authors: H
authors: Wang
authors: Stewart W
authors: SW
authors: Schneller