Endoplasmic reticulum (ER) stress-suppressive compounds from scrap cultivation beds of the mushroom Hericium erinaceum.
Four compounds were isolated from scrap cultivation beds of the mushroom, Hericium erinaceum. Compounds 1-4 were identified as methyl 4-hydroxy-3-(3-methylbutanoyl) benzoate, 2-chloro-1,3-dimethoxy-5-methylbenzene, methyl 4-chloro-3,5-dimethoxybenzoate, and 4-chloro-3,5-dimethoxybenzaldehyde by an interpretation of the NMR and MS data, respectively. This is the first reported isolation of 1 from a natural source. All the compounds showed protective activity against endoplasmic reticulum stress-dependent cell death.
Ueda
Keiko
K
Graduate School of Science and Technology, Shizuoka University, Japan.
Kodani
Shinya
S
Kubo
Masakazu
M
Masuno
Kazuhiko
K
Sekiya
Atsushi
A
Nagai
Kaoru
K
Kawagishi
Hirokazu
H
D001487:Basidiomycota / Q000737:chemistry* / Q000254:growth & development*; D001547:Benzaldehydes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001554:Benzene / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001565:Benzoates / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D004721:Endoplasmic Reticulum / Q000187:drug effects* / Q000473:pathology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D013312:Stress, Physiological / Q000187:drug effects*
D001547:Benzaldehydes; D001565:Benzoates; D001554:Benzene; C032175:benzaldehyde