Transgenic and targeted mutant mice in drug discovery.
In the process of drug discovery, different classes of genetically-modified animals are valuable tools for the identification of drug targets, distinction of target isoforms, differentiation of signaling pathways, generation of disease models and toxicological testing. The analysis is refined by methodologies which permit the inducible regulation of gene expression in a time- and tissue-specific manner. Finally, multiplexing techniques and knockout embryonic stem (ES) cell libraries will help to link DNA sequence information to biological function.
Rudolph
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ETH and University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland. rudolph@pharma.unizh.ch
Mohler
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