Oxygenated lignans from the fruits of Schisandra arisanensis.
An acetone extract of the fruits of the Taiwanese medicinal plant Schisandra arisanensis has yielded 11 new oxygenated lignans. Four of these, named arisantetralones A-D (1-4), possess the aryltetralone skeleton, while the other seven, named arisanschinins F-L (5-11), are polyoxygenated C(18)-dibenzocyclooctadiene lignans. Structures were determined on the basis of spectroscopic analyses, especially 2D-NMR techniques. The structure of compound 1 was confirmed by X-ray crystallographic analysis. Immunomodulatory activity of the isolated lignans was tested and evaluated.
Cheng
Yuan-Bin
YB
School of Pharmacy, College of Medicine, National Taiwan University, Jen-Ai Road Sec. 1, Taipei 100, Taiwan, Republic of China.
Chang
Meng-Ting
MT
Lo
Yi-Wen
YW
Ho
Ching-Jen
CJ
Kuo
Yuh-Chi
YC
Chien
Ching-Te
CT
Chen
Shun-Ying
SY
Liou
Shorong-Shii
SS
Kuo
Yao-Haur
YH
Shen
Ya-Ching
YC
D018360:Crystallography, X-Ray; D005638:Fruit / Q000737:chemistry; D006801:Humans; D007155:Immunologic Factors / Q000097:blood / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D017705:Lignans / Q000097:blood / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010100:Oxygen / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D032141:Schisandra / Q000737:chemistry*; D013624:Taiwan
D007155:Immunologic Factors; D017705:Lignans; D010100:Oxygen