title: Effects of cafeteria diet on the jejunum in sedentary and physically trained rats.
abstract: OBJECTIVE
  The effects of a cafeteria diet on the small intestine were investigated in adult Wistar rats under sedentary conditions and after physical training.
  
  
  METHODS
  Parameters including morphometry, enzyme activities, and total myenteric populations in the jejunum were evaluated.
  
  
  RESULTS
  The cafeteria diet, characterized as hyperlipidic, produced obese rats, corroborated by increases in the Lee index and the weights of the periepididymal and retroperitoneal adipose tissues (P<0.01). Obesity caused increases in the length of the small intestine, villi height, crypt depth, whole-wall thickness (P<0.05), and the enzymatic activities of alkaline phosphatase, lipase, and sucrase (P<0.01), in addition to a reduction in the number of goblet cells (P<0.05). With reference to the jejunal intrinsic innervations, the total number and area of myenteric neurons was unchanged regardless of the group. Physical training promoted 1) a reduction of the weight in the retroperitoneal and periepididymal adipose tissues (P<0.05) and 2) an increase in the thickness of the muscular layer (P<0.05).
  
  
  CONCLUSIONS
  The cafeteria diet promoted obesity in rodents, leading to alterations in morphometry and enzymatic intestinal parameters, which were partily attenuated by physical training.
authors: Department of Morphophysiological Sciences, State University of Maringá, Maringá, Paraná, Brazil. celiareginabio@hotmail.com
authors: Célia Regina
authors: CR
authors: Scoaris
authors: Gabriela Vasconcelos
authors: GV
authors: Rizo
authors: Luciana Patrícia
authors: LP
authors: Roldi
authors: Solange Marta Franzói
authors: SM
authors: de Moraes
authors: André Ricardo Gomes
authors: AR
authors: de Proença
authors: Rosane Marina
authors: RM
authors: Peralta
authors: Maria Raquel Marçal
authors: MR
authors: Natali
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects*; D000818:Animals; D004040:Dietary Carbohydrates / Q000008:administration & dosage*; D004041:Dietary Fats / Q000008:administration & dosage*; D005522:Food Services; D007583:Jejunum / Q000033:anatomy & histology / Q000187:drug effects*; D008297:Male; D009130:Muscle, Smooth / Q000187:drug effects; D009765:Obesity / Q000201:enzymology / Q000209:etiology* / Q000473:pathology; D009929:Organ Size; D010805:Physical Conditioning, Animal / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D004040:Dietary Carbohydrates; D004041:Dietary Fats