Trimethoprim/Sulfamethoxazole and azithromycin combination therapy for ocular toxoplasmosis.
OBJECTIVE
To evaluate the efficacy and safety of trimethoprim/sulfamethoxazole and azithromycin combination for the treatment of ocular toxoplasmosis.


METHODS
Nineteen ocular toxoplasmosis patients treated with trimethoprim/sulfamethoxazole and azithromycin +/- corticosteroid combination were retrospectively reviewed. Demographic data, clinical findings, the time interval until resolution of inflammation, recurrences, and drug side effects were collected.


RESULTS
The mean follow-up time of the patients was 25.0 +/- 22.5 (range; 6 -66) months. Final visual acuity improved with a mean of 6 +/- 4 lines in 15 patients (78.9%). Inflammatory findings began to subside within 14.8 +/- 10.0 days. Three patients (15.8%) had recurrent attack. Only 1 patient (5.3%) had side effects from therapy.


CONCLUSIONS
Trimethoprim/sulfamethoxazole and azithromycin combination is an effective and safe treatment modality for the treatment of ocular toxoplasmosis.
Yazici
Alper
A
Ulucanlar Eye Education and Research Hospital, Ankara, Turkey. lpryzc@gmail.com
Ozdal
Pinar Cakar
PC
Taskintuna
Ibrahim
I
Kavuncu
Sevim
S
Koklu
Gultekin
G
D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D000890:Anti-Infective Agents / Q000008:administration & dosage*; D017963:Azithromycin / Q000008:administration & dosage*; D002648:Child; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008266:Macula Lutea; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D013256:Steroids / Q000008:administration & dosage; D014126:Toxoplasmosis, Ocular / Q000188:drug therapy* / Q000503:physiopathology; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000008:administration & dosage* / Q000009:adverse effects; D014792:Visual Acuity / Q000187:drug effects; D055815:Young Adult
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D013256:Steroids; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D017963:Azithromycin