From GH to Billy Ghrelin.
The octanoylated peptide hormone ghrelin regulates episodic growth hormone release and energy balance. Work in genetically modified mice (Kirchner et al., 2009) now shows that in vivo activity of ghrelin O-acyltransferase (GOAT), responsible for ghrelin octanoylation, decreases during fasting but increases after ingesting medium-chain fatty acid triglycerides (MCT).
Smith
Roy G
RG
Department of Metabolism and Aging, The Scripps Research Institute Florida, Jupiter, FL 33458, USA. rgsmith@scripps.edu
D000217:Acyltransferases / Q000172:deficiency / Q000235:genetics / Q000378:metabolism; D000818:Animals; D005215:Fasting; D054439:Ghrelin / Q000235:genetics / Q000378:metabolism*; D013006:Growth Hormone / Q000378:metabolism*; D008565:Membrane Proteins; D051379:Mice; D008822:Mice, Transgenic; D054440:Receptors, Ghrelin / Q000378:metabolism
D054439:Ghrelin; D008565:Membrane Proteins; D054440:Receptors, Ghrelin; D013006:Growth Hormone; D000217:Acyltransferases; C526983:Mboat4 protein, mouse