Fine-tuning of T cell responses during infection.
Adequate control of infection relies on development of a tailored immune response according to the requirements of a given infection. This is achieved by the continuous crosstalk between innate and adaptive immunity. Pathogen diversity is deciphered via a plethora of receptors converging signals to adaptor molecules; tissue sites and environment generate additional signals that further influence T cell lineage decisions. Within this continuum of interactions, fine-tuning of the ensuing T cell responses together with plasticity of the committed T cells ensure development of balanced immune responses maintaining homeostasis. This review focuses on the multiple mechanisms that govern T cell differentiation during infection.
Dorhoi
Anca
A
Max Planck Institute for Infection Biology, Department of Immunology, Berlin, Germany. dorhoi@mpiib-berlin.mpg.de
Kaufmann
Stefan H E
SH
D056704:Adaptive Immunity; D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D001419:Bacteria / Q000276:immunology* / Q000472:pathogenicity; D001424:Bacterial Infections / Q000276:immunology* / Q000473:pathology; D002450:Cell Communication / Q000276:immunology*; D002454:Cell Differentiation; D016207:Cytokines / Q000276:immunology*; D005786:Gene Expression Regulation / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D051192:Receptors, Pattern Recognition; D013601:T-Lymphocytes / Q000276:immunology* / Q000382:microbiology / Q000473:pathology
D016207:Cytokines; D051192:Receptors, Pattern Recognition