Testing human otolith function using bone-conducted vibration.
Bone-conducted vibration of the forehead, in the midline at the hairline (Fz) causes linear acceleration stimulation of both mastoids and results in an ocular vestibular-evoked myogenic potential (oVEMP), recorded by surface electromyogram (EMG) electrodes just beneath the eyes. The early n10 component of the oVEMP is symmetrical in healthy subjects, absent in patients with bilateral vestibular loss, and in patients after unilateral vestibular loss (uVL) n10 is small or absent on the side contralateral to the uVL, but of normal amplitude on the side contralateral to the healthy ear. The n10 component probably reflects mainly otolithic function, since in the guinea pig, primary otolith irregular neurons are selectively activated by bone-conducted vibration (BCV) at low intensities (0.1 g), whereas semicircular canal primary afferents are not activated even at high intensities (10 g).
Curthoys
I S
IS
School of Psychology, University of Sydney, Sydney, Australia. ianc@psych.usyd.edu.au
Burgess
A M
AM
MacDougall
H G
HG
McGarvie
L A
LA
Halmagyi
G M
GM
Smulders
Y E
YE
Iwasaki
S
S
D001842:Bone and Bones / Q000502:physiology*; D006801:Humans; D010037:Otolithic Membrane / Q000502:physiology*; D014732:Vibration