title: [Tolerant mechanisms of bacteria to organic solvents].
abstract: Organic solvents are usually toxic to microorganisms for destroying the physiological functions. Recently, some studies have revealed that some bacteria are capable of living in conditions with high concentration of solvents through tolerant and adaptive mechanisms. This discovery inspires the research on adaptation and alteration of industrial bacteria, especially for those producing solvents or degrading toxic organic compounds. For a deep understanding and a wide application of the tolerant mechanisms, we address here the recent discoveries on solvents toxicity to bacteria by the parameter logP, and tolerant mechanisms of solvent-tolerant-bacteria to solvents, such as changes in cell membrane including cis-trans isomerisation, the saturated-to-unsaturated fatty acids ratio and the phospholipids head-groups, changes in outer membrane and cell morphology, and other stress responses. Moreover, our experiences in screening novel solvent-tolerant-bacteria and methods in increasing solvent tolerance of industrial microbes are introduced to give a promising strategy for improving solvent production.
authors: Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
authors: Xinxin
authors: X
authors: Wang
authors: Shaohua
authors: S
authors: Wang
authors: Wei
authors: W
authors: Li
authors: Yin
authors: Y
authors: Li
authors: Yanping
authors: Y
authors: Zhang
mesh_terms: D000222:Adaptation, Physiological / Q000187:drug effects; D001419:Bacteria / Q000187:drug effects*; D024881:Drug Resistance, Bacterial / Q000187:drug effects*; D007218:Industrial Microbiology / Q000379:methods; D009930:Organic Chemicals / Q000494:pharmacology*; D012997:Solvents / Q000494:pharmacology*
chemical_list: D009930:Organic Chemicals; D012997:Solvents