Emergence of oseltamivir-resistant influenza A H1N1 virus during the 2007-2008 winter season in Luxembourg: clinical characteristics and epidemiology.
Human cases of oseltamivir-resistant influenza A H1N1 virus emerging in 2007-2008 in Luxembourg were not associated with treatment, prophylaxis or stockpiling of oseltamivir. Following initial local seeding, oseltamivir-resistant strains spread synchronously to sensitive strains causing a similar epidemiology and clinical symptoms.
Mossong
Joël
J
Microbiology, National Health Laboratory, PO Box 1102, L-1011 Luxembourg, Luxembourg. joel.mossong@lns.etat.lu
Opp
Matthias
M
Gerloff
Nancy
N
Hau
Patrick
P
Kremer
Jacques
J
Lackenby
Angie
A
Gregory
Vicki
V
Even
Jos
J
Huberty-Krau
Pierrette
P
Muller
Claude P
CP
Schneider
François
F
D000293:Adolescent; D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D024882:Drug Resistance, Viral; D005260:Female; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000145:classification / Q000187:drug effects / Q000302:isolation & purification* / Q000502:physiology; D007251:Influenza, Human / Q000188:drug therapy / Q000453:epidemiology* / Q000821:virology; D008189:Luxembourg / Q000453:epidemiology; D008297:Male; D008969:Molecular Sequence Data; D053139:Oseltamivir / Q000627:therapeutic use*; D010802:Phylogeny; D012621:Seasons; D055815:Young Adult
D000998:Antiviral Agents; D053139:Oseltamivir