Drugs mediating myocardial protection.
The occurrence of myocardial ischaemia will result in either reversible or irreversible myocardial dysfunction. Even when revascularization is successful, some reperfusion injury may occur that transiently impairs myocardial function. Therefore, treatment should not only be directed towards prompt restoration of myocardial blood flow but measures should also be taken to prevent or alleviate the consequences of myocardial reperfusion injury. Over the years, various strategies have been developed. The present contribution reviews a number of these strategies focusing on pharmacological treatments that have been developed to address myocardial reperfusion injury.
De Hert
Stefan G
SG
Department of Anaesthesiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. s.g.dehert@amc.uva.nl
Preckel
Benedikt
B
Hollmann
Markus W
MW
Schlack
Wolfgang S
WS
D000777:Anesthetics / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism; D006801:Humans; D019157:Ischemic Preconditioning, Myocardial / Q000379:methods*; D017202:Myocardial Ischemia / Q000503:physiopathology*; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control*; D010100:Oxygen / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism
D000777:Anesthetics; D017382:Reactive Oxygen Species; D010100:Oxygen; D002118:Calcium