title: Narrow band imaging videobronchoscopy improves assessment of lung cancer extension and influences therapeutic strategy.
abstract: OBJECTIVE
  Narrow band imaging (NBI) videobronchoscopy is a new technique aimed at lung cancer detection. This study investigated its sensitivity and specificity for evaluation of lung cancer extension and its possible influence on therapeutic decision, compared with white light videobronchoscopy.
  
  
  METHODS
  In this prospective study, we evaluated 106 patients with suspected lung cancer. All patients were examined using EVIS LUCERA videoendoscopy system. In every patient, at least three biopsies were taken from places visualized as pathologic, surrounding primary tumor, and three biopsies from places that appeared normal. The overall number of biopsies performed in 106 patients was 636.
  
  
  RESULTS
  The specificity and sensitivity of NBI in revealing greater lung cancer extension were 85.6% and 95%, respectively; positive and negative predictive values were 84% and 95.6%, respectively. Specificity and sensitivity were significantly better when compared with white light bronchoscopy alone (P < 0.01). NBI led to the change in therapeutic decision in 14 patients. There was statistically significant correlation between NBI assessment of tumor extension and change in therapeutic decision (P < 0.000).
  
  
  CONCLUSIONS
  NBI showed significantly better specificity and sensitivity in the assessment of lung cancer extension. NBI proved that it might have potential influence on therapeutic decision, making it more accurate. The procedure is safe and easily deployed in everyday practice.
authors: Faculty of Medicine, Department for Interventional Pulmonology, Clinic for Pulmonary Oncology, Institute for Pulmonary Diseases of Vojvodina, University of Novi Sad, Institutski put 4, Sremska Kamenica, Serbia. bojanzaric@neobee.net
authors: Bojan
authors: B
authors: Zaric
authors: Heinrich D
authors: HD
authors: Becker
authors: Branislav
authors: B
authors: Perin
authors: Aleksandra
authors: A
authors: Jovelic
authors: Goran
authors: G
authors: Stojanovic
authors: Miroslav D
authors: MD
authors: Ilic
authors: Zivka
authors: Z
authors: Eri
authors: Milana
authors: M
authors: Panjkovic
authors: Dusanka
authors: D
authors: Obradovic
authors: Milan
authors: M
authors: Antonic
mesh_terms: D000328:Adult; D000368:Aged; D001999:Bronchoscopy / Q000379:methods*; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D003952:Diagnostic Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D014741:Video Recording