title: [GST polymorphism and cytogenetic changes in lung tissues of lung cancer patients].
abstract: Carriers of GSTTI gene deletion were found to be more subjected to a risk of emerging non-small-cell lung cancer (NSLC) than those of normal GSTT1(+) genotype. Study on the relation between GST gene polymorphism and cytogenetic indices in lung cancer patients has shown a significant excess of the group average level in cells with micronuclei in NSLC patients with GSTTI(-). The frequency of cells with micronuclei was higher in smoking patients with a mutant genotype than in smoking carriers of the GSTT1(+) genotype.
authors: N N
authors: NN
authors: Chakova
authors: E P
authors: EP
authors: Mikhalenko
authors: S N
authors: SN
authors: Polonetskaia
authors: N V
authors: NV
authors: Chebotareva
authors: Iu E
authors: IuE
authors: Demidchik
authors: A A
authors: AA
authors: Zhilko
authors: O V
authors: OV
authors: Kvitko
authors: E V
authors: EV
authors: Krupnova
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000201:enzymology / Q000209:etiology / Q000235:genetics* / Q000473:pathology; D020732:Cytogenetic Analysis; D004247:DNA / Q000235:genetics; D017353:Gene Deletion; D020022:Genetic Predisposition to Disease; D005982:Glutathione Transferase / Q000235:genetics*; D006720:Homozygote; D006801:Humans; D008168:Lung / Q000201:enzymology / Q000473:pathology; D008175:Lung Neoplasms / Q000201:enzymology / Q000209:etiology / Q000235:genetics* / Q000473:pathology; D048629:Micronuclei, Chromosome-Defective; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012306:Risk; D012907:Smoking / Q000009:adverse effects
chemical_list: D004247:DNA; D005982:Glutathione Transferase; C413545:glutathione S-transferase T1