title: sPhospholipase A(2) is inhibited by anthocyanidins.
abstract: Epidemiological studies suggest that nutritional antioxidants may reduce the incidence of neurodegenerative disorders and age-related cognitive decline. Specifically, protection against oxidative stress and inflammation has served as a rationale for promoting diets rich in vegetables and fruits. The present study addresses secretory phospholipase A(2) (sPLA(2)) as a novel candidate effector of neuroprotection conferred by anthocyanins and anthocyanidins. Using a photometric assay, 15 compounds were screened for their ability to inhibit PLA(2). Of these, cyanidin, malvidin, peonidin, petunidin, and delphinidin achieved K(i) values <or=18 microM, suggesting a modulatory role for berry polyphenols in phospholipid metabolism.
authors: Department of Psychiatry, University of Regensburg, Regensburg, Germany. andrea.dreiseitel@klinik.uni-regensburg.de
authors: Andrea
authors: A
authors: Dreiseitel
authors: Gabriele
authors: G
authors: Korte
authors: Peter
authors: P
authors: Schreier
authors: Anett
authors: A
authors: Oehme
authors: Sanja
authors: S
authors: Locher
authors: Goeran
authors: G
authors: Hajak
authors: Philipp G
authors: PG
authors: Sand
mesh_terms: D000872:Anthocyanins / Q000737:chemistry / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D004789:Enzyme Activation / Q000187:drug effects*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D066298:In Vitro Techniques; D008956:Models, Chemical; D054467:Phospholipases A2 / Q000378:metabolism*; D010783:Photometry / Q000379:methods
chemical_list: D000872:Anthocyanins; D004791:Enzyme Inhibitors; D054467:Phospholipases A2