title: Feline perforating dermatitis resembling human reactive perforating collagenosis: clinicopathological findings and outcome in four cases.
abstract: The clinicopathological findings of perforating dermatitis in two young and two adult cats are described. In all cases, the lesions were characterized by single or multiple papules and plaques, 0.5-3.0 cm in diameter, each containing a central, firm, exophytic, cone-shaped, yellow-orange keratotic plug, tightly adherent to the underlying skin. Removal of the protruding material was associated with bleeding and left the ulcerated surface exposed. In one case, the lesions showed a linear configuration and identical lesions occurred on the suture sites following biopsy. Histopathologically, the diagnosis was straightforward because of the presence of vertically orientated collagen bundles extruded from ulcerated, concave-shaped invaginations of the skin. In two cases, vitamin C administration failed to resolve the disease. In two cases, methyl-prednisolone acetate was used to manage relapsing episodes and vitamin C helped to reduce glucocorticoid requirements. In one case, treatment with methyl-prednisolone acetate only appeared to be curative. The fourth case was lost to follow-up immediately after the diagnosis.
authors: Private practice, Clinica Veterinaria L'Arca, 80129 - Naples, Italy.
authors: Francesco
authors: F
authors: Albanese
authors: Chiara
authors: C
authors: Tieghi
authors: Luigi
authors: L
authors: De Rosa
authors: Silvia
authors: S
authors: Colombo
authors: Francesca
authors: F
authors: Abramo
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001205:Ascorbic Acid / Q000627:therapeutic use; D002371:Cat Diseases / Q000473:pathology* / Q000628:therapy; D002415:Cats; D003872:Dermatitis / Q000473:pathology / Q000628:therapy / Q000662:veterinary*; D005260:Female; D008297:Male; D008775:Methylprednisolone / Q000031:analogs & derivatives / Q000627:therapeutic use; D000077555:Methylprednisolone Acetate
chemical_list: D000893:Anti-Inflammatory Agents; D000077555:Methylprednisolone Acetate; D001205:Ascorbic Acid; D008775:Methylprednisolone