[Propofol combined with midazolam intravenous sedation anesthesia in pediatric upper gastrointestinal endoscopy].
OBJECTIVE
To explore the application of propofol combined with midazolam intravenous anesthesia in pediatric upper gastrointestinal endoscopy.


METHODS
A total of 497 ASA I~II patients who received sedative upper gastrointestinal endoscopy were assigned to a children group (2-14 years) and an adults group (18-65 years).The 2 groups were treated with midazolam (0.02-0.03 mg/kg, iv) and propofol(0.6-0.7 mg/s,iv) with an interval of 3-5 minutes. Enterscopy was inserted at light sleep, relaxing muscles, and disappearance of eyelash relaxation. Combining of pro-endoscopy, reaction to intravenous administration, dose of propofol, reaction to endoscopy, time of returning to consciousness, changes of SpO2, R, HR, and BP, and sedative quality were evaluated.


RESULTS
Good sedation of the 2 groups after intravenous administration was observed. Rate of combining of pro-endoscopy in children was lower (42%) than that in adults(100%). The incidence of restlessness, hyperphasia, temporary decreasing of SpO2, dose of propofol of per kilogram weight, time of returning to consciousness in the children were 82.7%, 17%, 2.4 mg/kg, and (17.5+/-3.2) min, respectively, which were all higher in the adults [9%, 4%, 1.4 mg/kg, and (9.5+/-1.3) min, P<0.01]. HR and BP decreased in the 2 groups, and recovered rapidly after the endoscopy. There was no significant difference between the 2 groups(P>0.05).


CONCLUSIONS
It is safe and effective to use propofol combined with midazolam intravenous sedation anesthesia in pediatric upper gastrointestinal endoscopy.
Xiao
Dinghua
D
Department of Gastroenterology, Third Xiangya Hospital, Central South University, Changsha 410013, China.
Wang
Fen
F
Wang
Xiaoyan
X
Tang
Wuliang
W
Ouyang
Wen
W
Shen
Shourong
S
D000293:Adolescent; D000328:Adult; D000368:Aged; D018686:Anesthetics, Intravenous / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D016292:Procedural Sedation; D016099:Endoscopy, Gastrointestinal / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008874:Midazolam / Q000627:therapeutic use*; D008875:Middle Aged; D015742:Propofol / Q000627:therapeutic use*; D055815:Young Adult
D018686:Anesthetics, Intravenous; D008874:Midazolam; D015742:Propofol