Aminoacetone as the penultimate precursor to the antitumor agent azinomycin A.
Experiments reveal that the metabolic precursor aminoacetone is a key intermediate in the production of the antitumor agent azinomycin A relative to the structurally and functionally related agent, azinomycin B. Azinomycin A and B arise through bifurcation of the biosynthetic pathway and competition between metabolic substrates. The availability of the biosynthetic precursors in vivo, aminoacetone for azinomycin A and threonine for azinomycin B, controls the overall ratio of azinomycin A to B produced.
Sharma
Vasudha
V
Department of Chemistry, Texas A&M University, College Station, Texas 77843, USA.
Kelly
Gilbert T
GT
Foulke-Abel
Jennifer
J
Watanabe
Coran M H
CM
D000096:Acetone / Q000031:analogs & derivatives* / Q000737:chemistry; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D053961:Azabicyclo Compounds; D004151:Dipeptides; D006020:Glycopeptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D036341:Intercellular Signaling Peptides and Proteins; D015394:Molecular Structure; D009281:Naphthalenes; D010455:Peptides
D000970:Antineoplastic Agents; D053961:Azabicyclo Compounds; D004151:Dipeptides; D006020:Glycopeptides; D036341:Intercellular Signaling Peptides and Proteins; D009281:Naphthalenes; D010455:Peptides; C051055:azinomycin B; C051054:azinomycin A; D000096:Acetone; C006495:aminoacetone