title: Pre- and post- donation haematological values in healthy donors undergoing plateletpheresis with five different systems.
abstract: BACKGROUND
  Although automated cell separators have undergone a lot of technical refinements, attention has been focused more on the quality of platelet concentrates than on donor safety. We planned this prospective study to observe the effects of automated plateletpheresis on normal haematological values of healthy donors and to determine whether the haematological alterations had any clinical consequences.
  
  
  METHODS
  The study was conducted on 457 healthy, first-time plateletpheresis donors over a period of 26 months. The plateletpheresis procedures were performed using five different cell separators and various pre- and post-donation haematological values such as haemoglobin concentration (Hb), haematocrit (Hct), platelet and white blood cell (WBC) counts, mean platelet volume and platelet distribution width were measured in all donors.
  
  
  RESULTS
  We observed that the Hb, Hct, platelet and WBC counts decreased significantly in the donors (p<0.01) after each procedure, without there being significant changes in mean platelet volume or platelet distribution width. The decreases in Hb and Hct were significantly greater with the CS 3000 and Amicus machines, while the decreases in platelet and WBC counts were significantly greater with the CS 3000 and Fresenius separators.
  
  
  CONCLUSIONS
  Although a significant drop in complete blood count was observed in all donors, none manifested features of thrombocytopenia or anaemia. Nevertheless, more prospective studies on this aspect are required in order to establish guidelines for donor safety in apheresis and also to help in assessing donor suitability, especially given the present trend of double product apheresis collections.
authors: Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
authors: Sudipta Sekhar
authors: SS
authors: Das
authors: Rajendra
authors: R
authors: Chaudhary
authors: Sunil Kumar
authors: SK
authors: Verma
authors: Shashank
authors: S
authors: Ojha
authors: Dheeraj
authors: D
authors: Khetan
mesh_terms: D000328:Adult; D001782:Blood Donors; D005260:Female; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis*; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D010983:Plateletpheresis / Q000009:adverse effects / Q000295:instrumentation* / Q000379:methods
chemical_list: D006454:Hemoglobins