Solid-phase random glycosylation.
Two different approaches were employed to study solid phase random glycosylations to obtain oligosaccharide libraries. In approach I, Wang resin esters were attached to the acceptors structures. Following their glycosylation and resin cleavage, the peracetylated components of the oligosaccharide libraries were characterized. In approach II, polymer-linked donor components could be employed and processed correspondingly. Approach I proved to be superior regarding yield and versatility of products and also allowed the formation of higher oligomers.
Agoston
Károly
K
Department of Chemistry, Faculty of Science, University of Hamburg, Martin-Luther-King-Platz 6, D-20146 Hamburg, Germany.
Kröger
Lars
L
Dékány
Gyula
G
Thiem
Joachim
J
D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D020650:Combinatorial Chemistry Techniques; D006031:Glycosylation; D009682:Magnetic Resonance Spectroscopy; D009844:Oligosaccharides / Q000138:chemical synthesis* / Q000737:chemistry
D009844:Oligosaccharides