title: Arylcarboxyamino-substituted diaryl ureas as potent and selective FLT3 inhibitors.
abstract: A series of diaryl ureas with an amide substitution at the 4-position was prepared and found to be potent and selective FLT3 inhibitors with good oral bioavailability and efficacy in a tumor xenograft model.
authors: Ambit Biosciences Inc., 4215 Sorrento Valley Boulevard, San Diego, CA 92121, USA.
authors: Hitesh K
authors: HK
authors: Patel
authors: Robert M
authors: RM
authors: Grotzfeld
authors: Andiliy G
authors: AG
authors: Lai
authors: Shamal A
authors: SA
authors: Mehta
authors: Zdravko V
authors: ZV
authors: Milanov
authors: Qi
authors: Q
authors: Chao
authors: Kelly G
authors: KG
authors: Sprankle
authors: Todd A
authors: TA
authors: Carter
authors: Anne Marie
authors: AM
authors: Velasco
authors: Miles A
authors: MA
authors: Fabian
authors: Joyce
authors: J
authors: James
authors: Daniel K
authors: DK
authors: Treiber
authors: David J
authors: DJ
authors: Lockhart
authors: Patrick P
authors: PP
authors: Zarrinkar
authors: Shripad S
authors: SS
authors: Bhagwat
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics; D045744:Cell Line, Tumor; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D013329:Structure-Activity Relationship; D014508:Urea / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000493:pharmacokinetics; D023041:Xenograft Model Antitumor Assays; D051941:fms-Like Tyrosine Kinase 3 / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D014508:Urea; D051941:fms-Like Tyrosine Kinase 3