title: Analysis of single nucleotide polymorphisms in the FAS and CTLA-4 genes of peripheral T-cell lymphomas.
abstract: Angioimmunoblastic T-cell lymphoma (AILT) represents a subset of T-cell lymphomas but resembles an autoimmune disease in many of its clinical aspects. Despite the phenotype of effector T-cells and high expression of FAS and CTLA-4 receptor molecules, tumor cells fail to undergo apoptosis. We investigated single nucleotide polymorphisms (SNPs) of the FAS and CTLA-4 genes in 94 peripheral T-cell lymphomas. Although allelic frequencies of some FAS SNPs were enriched in AILT cases, none of these occurred at a different frequency compared to healthy individuals. Therefore, SNPs in these genes are not associated with the apoptotic defect and autoimmune phenomena in AILT.
authors: Institute of Pathology, University of Würzburg, Josef Schneider Strasse 2, 97080, Würzburg, Germany, irinabonzheim@gmx.de.
authors: Irina
authors: I
authors: Bonzheim
authors: Eva
authors: E
authors: Geissinger
authors: Wen-Yu
authors: WY
authors: Chuang
authors: Sabine
authors: S
authors: Roth
authors: Philipp
authors: P
authors: Ströbel
authors: Alexander
authors: A
authors: Marx
authors: Peter
authors: P
authors: Reimer
authors: Martin
authors: M
authors: Wilhelm
authors: Bernhard
authors: B
authors: Puppe
authors: Andreas
authors: A
authors: Rosenwald
authors: Hans Konrad
authors: HK
authors: Müller-Hermelink
authors: Thomas
authors: T
authors: Rüdiger