title: No association between phosphatase and tensin homolog genetic polymorphisms and colon cancer.
abstract: OBJECTIVE
  To investigate the association between single nucleotide polymorphisms (SNPs) in the phosphatase and tensin homolog (PTEN) tumor suppressor gene and risk of colon cancer.
  
  
  METHODS
  We utilized a population-based case-control study of incident colon cancer individuals (n = 421) and controls (n = 483) aged > or = 30 years to conduct a comprehensive tagSNP association analysis of the PTEN gene.
  
  
  RESULTS
  None of the PTEN SNPs were statistically significantly associated with colon cancer when controlled for age, gender, and race, or when additionally adjusted for other known risk factors (P > 0.05). Haplotype analyses similarly showed no association between the PTEN gene and colon cancer.
  
  
  CONCLUSIONS
  Our study does not support PTEN as a colon cancer susceptibility gene.
authors: Department of Epidemiology and Biostatistics and Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106-7136, United States.
authors: Lynette S
authors: LS
authors: Phillips
authors: Cheryl L
authors: CL
authors: Thompson
authors: Alona
authors: A
authors: Merkulova
authors: Sarah J
authors: SJ
authors: Plummer
authors: Thomas C
authors: TC
authors: Tucker
authors: Graham
authors: G
authors: Casey
authors: Li
authors: L
authors: Li
mesh_terms: D003110:Colonic Neoplasms / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D051059:PTEN Phosphohydrolase / Q000235:genetics* / Q000378:metabolism; D011110:Polymorphism, Genetic
chemical_list: D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human