Susceptibility of mantle cell lymphomas to reovirus oncolysis.
Mantle cell lymphoma (MCL) an incurable B-cell, non-Hodgkin lymphoma (NHL) urgently requires new treatments. We assessed reovirus mediated oncolysis in a panel of human MCL cell lines. In vitro, we found the cytopathic effect of reovirus infection ranged from high to very limited and correlated with levels of Ras activation. In vivo, a single reovirus injection intra-tumorally resulted in complete regression of both the injected and the contra-lateral tumor in a subcutaneous bi-tumor model, in one out of three cell lines tested. Reovirus treatment of MCL seems feasible but will need to be guided by the presence of molecular determinants of reovirus susceptibility.
Alain
Tommy
T
Translational Research Laboratory, Tom Baker Cancer Centre, Calgary, Alberta, Canada.
Muzik
Huong
H
Otsuka
Shannon
S
Chan
Salina
S
Magliocco
Tony
T
Diaz
Roman
R
Forsyth
Peter A
PA
Morris
Don
D
Bebb
Gwyn
G
D000818:Animals; D006801:Humans; D006868:Hydrolysis; D020522:Lymphoma, Mantle-Cell / Q000628:therapy*; D051379:Mice; D050130:Oncolytic Virotherapy; D012087:Reoviridae / Q000502:physiology*