title: The relationship between self-reported history of endodontic therapy and coronary heart disease in the Atherosclerosis Risk in Communities Study.
abstract: BACKGROUND
  Results from numerous studies have suggested links between periodontal disease and coronary heart disease (CHD), but endodontic disease has not been studied extensively in this regard.
  
  
  METHODS
  The authors evaluated the relationship between self-reported history of endodontic therapy (ET) and prevalent CHD in the Atherosclerosis Risk in Communities (ARIC) Study, aprospective epidemiologic study sponsored by the National Heart, Lung, and Blood Institute. The authors used multivariable logistic regressionto analyze data obtained from oral health questionnaires, medical evaluations and clinical dental examinations.
  
  
  RESULTS
  Of 6,651 participants analyzed, 50.4 percent reported never having had ET; 21.5 percent reported having had ET one time; and 28.0 percent reported having had ET two or more times. Final multivariable regression models indicated that among participants with 25 or more teeth, those reporting having had ET two or more times had 1.62 (95 percent confidence interval [CI], 1.04-2.53) times the odds of prevalent CHD compared with those reporting never having had ET. Among participants with 24 or fewer teeth, no significant differences in CHD prevalence were observed among groups regardless of their history of ET.
  
  
  CONCLUSIONS
  Among participants with 25 or more teeth, those with a greater self-reported history of ET were more likely to have CHD than were those reporting no history of ET.
  
  
  CONCLUSIONS
  More accurate epidemiologic quantification of endodontic infection and inflammation is required before definitive conclusions can be made about potential relationships between endodontic disease and CHD.
authors: Department of Preventive and Community Dentistry, College of Dentistry, University of Iowa, Iowa City, Iowa 52242. USA dan-caplan@uiowa.edu
authors: Daniel J
authors: DJ
authors: Caplan
authors: James S
authors: JS
authors: Pankow
authors: Jianwen
authors: J
authors: Cai
authors: Steven
authors: S
authors: Offenbacher
authors: James D
authors: JD
authors: Beck
mesh_terms: D000367:Age Factors; D050197:Atherosclerosis / Q000453:epidemiology*; D015331:Cohort Studies; D003327:Coronary Disease / Q000453:epidemiology*; D003430:Cross-Sectional Studies; D003442:Crowns / Q000706:statistics & numerical data; D004245:DMF Index; D003731:Dental Caries / Q000453:epidemiology; D003788:Dental Pulp Diseases / Q000453:epidemiology; D003920:Diabetes Mellitus / Q000453:epidemiology; D016021:Epidemiologic Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D007576:Jaw, Edentulous, Partially / Q000453:epidemiology; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D017622:Periodontal Attachment Loss / Q000453:epidemiology; D010514:Periodontal Pocket / Q000453:epidemiology; D010808:Physical Examination; D015995:Prevalence; D011446:Prospective Studies; D044469:Racial Groups; D012390:Root Canal Therapy / Q000706:statistics & numerical data*; D012737:Sex Factors; D012907:Smoking / Q000453:epidemiology; D011795:Surveys and Questionnaires; D014481:United States / Q000453:epidemiology