Affect of seizures during gestation on pregnancy outcomes in women with epilepsy.
OBJECTIVE
To assess whether seizures in women with epilepsy during pregnancy contribute to adverse pregnancy outcomes.


METHODS
A retrospective cross-sectional study.


METHODS
Taiwan. Patients This study linked 2 nationwide population-based data sets: Taiwan's birth certificate registry and the Taiwan National Health Insurance Research Data set. A total of 1016 women with epilepsy were selected who had single births from 2001 to 2003 and who had been diagnosed with epilepsy within 2 years prior to their index delivery, together with 8128 matched women without chronic disease as a comparison cohort. Women with epilepsy were further stratified into 2 groups for analysis: women who did and did not have seizures during pregnancy.


METHODS
Low-birth-weight infants, preterm delivery, and infants who are small for gestational age (SGA).


RESULTS
Compared with women without epilepsy, epileptic seizures during pregnancy were independently associated with a 1.36-fold (95% confidence interval [CI], 1.01-1.88), 1.63-fold (95% CI, 1.21-2.19), and 1.37-fold (95% CI, 1.09-1.70) increased risk of low-birth-weight infants, preterm delivery, and SGA, respectively, after adjusting for family income and parental and infant characteristics. Further, the risk of SGA increased significantly (odds ratio, 1.34; 95% CI, 1.01-1.84) for women with seizures during pregnancy compared with women with epilepsy who did not have seizures during pregnancy.


CONCLUSIONS
We suggest preventing seizures during pregnancy as an essential step to reduce risk of adverse pregnancy outcomes.
Chen
Yi-Hua
YH
School of Public Health, Taipei Medical University, Taipei, Taiwan.
Chiou
Hung-Yi
HY
Lin
Herng-Ching
HC
Lin
Hsiu-Li
HL
D000328:Adult; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D004522:Educational Status; D004827:Epilepsy / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D008297:Male; D007752:Obstetric Labor, Premature / Q000453:epidemiology*; D010331:Paternal Age; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology*; D011256:Pregnancy Outcome / Q000453:epidemiology*; D012042:Registries; D012306:Risk; D012307:Risk Factors; D012959:Socioeconomic Factors; D013624:Taiwan; D055815:Young Adult