title: [Effect of Panax notoginseng saponins on syp and tau gene expression in brain of senescence accelerated mouse].
abstract: OBJECTIVE
  To study the effect of Panax notoginseng saponins (PNS) on (synaptophysin, syp) and tau gene expression in the brain tissue in senescence accelerated mouse prone 8 (SAMP 8).
  
  
  METHODS
  SAMP8 were randomly divided into 4 groups: PNS 23.38, 93.50 mg x kg(-1) group, huperzin A 0.038 6 mg x kg(-1) x d(-1) group and blank control group; the drug groups were treated with the designed drugs respectively per day by intragastric administration for 4 consecutive weeks, and double distilled water was given to blank control group. After treatment, the mRNA content of tau and syp were assayed by reverse transcription (RT) and real-time polymerase chain reaction (real-time PCR).
  
  
  RESULTS
  Compared with blank control group, the syp mRNA contents were increased in PNS groups (P < 0.05 or P < 0.01), and the tau mRNA content were not significant difference in all groups.
  
  
  CONCLUSIONS
  This study suggests that PNS can up-regulate syp gene expression at transcriptional level in the brain of SAMP 8.
authors: Center of Research and Development of New Drugs, Guangxi Chinese Traditional Medical University, Nanning 530001, China.
authors: Liang
authors: L
authors: Lv
authors: Zhenguo
authors: Z
authors: Zhong
authors: Dengpan
authors: D
authors: Wu
authors: Limin
authors: L
authors: Chai
authors: Wenyan
authors: W
authors: Zhang
mesh_terms: D000375:Aging / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D015870:Gene Expression / Q000187:drug effects* / Q000235:genetics; D051379:Mice; D053723:Panax notoginseng / Q000737:chemistry*; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11 / Q000235:genetics / Q000378:metabolism; D012503:Saponins / Q000494:pharmacology*; D016875:tau Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: D012503:Saponins; D016875:tau Proteins; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11; C516725:Ptpn11 protein, mouse