title: Sensitivity and spatial resolution of transvenous leads in implantable cardioverter defibrillator.
abstract: It has been previously documented that the main features and sensing performance of electrograms (EGMs) recorded in implantable cardioverter defibrillators (ICDs) depend on lead configuration. Although this dependence has been ascribed to differences in lead sensitivity and spatial resolution, the quantification of these two properties on ICD has not yet been attempted. In this paper, an operative framework to study the spatial resolution of ICD transvenous leads is presented. We propose to quantify the spatial resolution of ICD transvenous leads based on a new characterization called lead resolution volume (ResV). We analyzed the sensitivity distribution and the ResV of two unipolar (tip-can and coil-can ) and two bipolar (true or tip-ring and integrated or tip-coil) ICD transvenous lead configurations. A detailed 3-D model of the human thorax based on the visible human man dataset was used to compute the lead sensitivity and computer simulations of simple cardiac dynamics were used to quantify the ResV. Differences in the sensitivity distribution throughout the ventricular myocardium (VM) were observed for each lead configuration. In our computer model of the human thorax, the ResV was found to comprise 7%, 35%, 45%, and 70% of the VM for true bipolar, integrated bipolar, tip-can unipolar, and coil-can unipolar ICD leads, respectively. Furthermore, our analysis shows that the spatial resolution depends on both lead sensitivity and cardiac dynamics, and therefore, it can vary for different heart rhythms.
authors: Department of Signal Theory and Communications, Rey Juan Carlos University, Madrid 28943, Spain. jesus.requena@urjc.es
authors: Jesús
authors: J
authors: Requena-Carrión
authors: Juho
authors: J
authors: Väisänen
authors: Felipe
authors: F
authors: Alonso-Atienza
authors: Arcadi
authors: A
authors: García-Alberola
authors: Francisco Javier
authors: FJ
authors: Ramos-López
authors: José Luis
authors: JL
authors: Rojo-Alvarez
mesh_terms: D003198:Computer Simulation; D017147:Defibrillators, Implantable; D003936:Diagnosis, Computer-Assisted / Q000295:instrumentation* / Q000379:methods; D004562:Electrocardiography / Q000295:instrumentation* / Q000379:methods; D004567:Electrodes, Implanted; D006329:Heart Conduction System / Q000502:physiology*; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D008955:Models, Cardiovascular; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity