Activation of NF-kB pathway by virus infection requires Rb expression.
The retinoblastoma protein Rb is a tumor suppressor involved in cell cycle control, differentiation, and inhibition of oncogenic transformation. Besides these roles, additional functions in the control of immune response have been suggested. In the present study we investigated the consequences of loss of Rb in viral infection. Here we show that virus replication is increased by the absence of Rb, and that Rb is required for the activation of the NF-kB pathway in response to virus infection. These results reveal a novel role for tumor suppressor Rb in viral infection surveillance and further extend the concept of a link between tumor suppressors and antiviral activity.
Garcia
Maria A
MA
Centro Nacional de Biotecnología, CSIC, Campus Universidad Autónoma, Madrid, Spain.
Gallego
Pedro
P
Campagna
Michela
M
González-Santamaría
José
J
Martínez
Gloria
G
Marcos-Villar
Laura
L
Vidal
Anxo
A
Esteban
Mariano
M
Rivas
Carmen
C
D000818:Animals; D002478:Cells, Cultured; D051379:Mice; D018345:Mice, Knockout; D016328:NF-kappa B / Q000378:metabolism*; D016160:Retinoblastoma Protein / Q000378:metabolism*; D054243:Vesicular Stomatitis / Q000378:metabolism*
D016328:NF-kappa B; D016160:Retinoblastoma Protein