title: Ancient repeat sequence derived from U6 snRNA in primate genomes.
abstract: LINE-1 (L1) is the most represented sequence of the human genome (17% of the total genomic mass). Moreover, it has been proposed for many years and demonstrated more recently that L1 has contributed to the mobilization of pseudogenes, small non-coding RNAs, such as tRNAs or snRNAs, and SINEs. In fact, it is estimated that L1 is responsible for at least 30% of our genome. The mobilization of non-L1 RNAs can occur in different ways and at different steps of the retrotransposition cycle. Here, by looking at U6 snRNA sequences mobilized by L1, we have observed an ancient repeat sequence derived from U6, present in all primate genomes. We were able to trace its origin in Euarchota genomes, most likely during the divergence of the four orders; Scandentia, Dermoptera, Plesiadapiform (extinct) and Primates.
authors: Institut de Génétique Humaine, Centre National de la Recherche Scientifique, 141 Rue de la Cardonille, 34396 Montpellier Cedex 5, France.
authors: Manel
authors: M
authors: Hasnaoui
authors: Aurélien J
authors: AJ
authors: Doucet
authors: Oussama
authors: O
authors: Meziane
authors: Nicolas
authors: N
authors: Gilbert
mesh_terms: D000818:Animals; D001483:Base Sequence; D019143:Evolution, Molecular; D016678:Genome / Q000502:physiology; D006801:Humans; D008969:Molecular Sequence Data; D010802:Phylogeny; D011323:Primates / Q000235:genetics*; D012342:RNA, Small Nuclear / Q000235:genetics*; D012091:Repetitive Sequences, Nucleic Acid / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid
chemical_list: D012342:RNA, Small Nuclear; C405486:U6 small nuclear RNA