Homologue pairing: getting it right.
In Caernorhabditis elegans, homologue pairing is mediated by specialized regions near one end of each chromosome in conjunction with zinc finger (ZnF)-bearing proteins. Families of repeated sequences that are enriched within these regions have now been identified. By recruiting their cognate ZnF-bearing proteins, these regions promote pairing and synapsis.
Hawley
R Scott
RS
Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA. rsh@stowers.org
Gilliland
William D
WD
D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics* / Q000378:metabolism; D029742:Caenorhabditis elegans Proteins / Q000235:genetics / Q000378:metabolism; D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism; D002868:Chromosomal Proteins, Non-Histone / Q000235:genetics / Q000378:metabolism; D023902:Chromosome Pairing / Q000235:genetics*; D008540:Meiosis / Q000235:genetics*; D008954:Models, Biological; D013573:Synaptonemal Complex / Q000235:genetics / Q000378:metabolism; D014960:X Chromosome / Q000235:genetics*
D029742:Caenorhabditis elegans Proteins; D018797:Cell Cycle Proteins; D002868:Chromosomal Proteins, Non-Histone; C507738:HIM-8 protein, C elegans; C516318:Zim-1 protein, C elegans; C516319:Zim-2 protein, C elegans; C516320:Zim-3 protein, C elegans