title: A customized and versatile high-density genotyping array for the mouse.
abstract: We designed a high-density mouse genotyping array containing 623,124 single-nucleotide polymorphisms that captures the known genetic variation present in the laboratory mouse. The array also contains 916,269 invariant genomic probes targeted to functional elements and regions known to harbor segmental duplications. The array opens the door to the characterization of genetic diversity, copy-number variation, allele-specific gene expression and DNA methylation, and will extend the successes of human genome-wide association studies to the mouse.
authors: The Jackson Laboratory, Bar Harbor, Maine, USA.
authors: Hyuna
authors: H
authors: Yang
authors: Yueming
authors: Y
authors: Ding
authors: Lucie N
authors: LN
authors: Hutchins
authors: Jin
authors: J
authors: Szatkiewicz
authors: Timothy A
authors: TA
authors: Bell
authors: Beverly J
authors: BJ
authors: Paigen
authors: Joel H
authors: JH
authors: Graber
authors: Fernando Pardo-Manuel
authors: FP
authors: de Villena
authors: Gary A
authors: GA
authors: Churchill
mesh_terms: D000818:Animals; D001482:Base Composition; D004247:DNA / Q000235:genetics; D005838:Genotype; D051379:Mice; D009693:Nucleic Acid Hybridization; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D020641:Polymorphism, Single Nucleotide
chemical_list: D004247:DNA