title: Relationship of urinary cGMP excretion with aging and menopausal status in a general population.
abstract: OBJECTIVE
  Aging and postmenopausal women are associated with increased risks of cardiovascular disease; however, epidemiological evidence concerning the relationship of aging and the menopause with vascular biological activity is limited.
  
  
  METHODS
  We investigated the relationship of aging and the menopause with urinary excretion of cyclic guanosine 3',5' monophosphate (cGMP) in 1,541 Japanese men and women aged 40 to 79 years. The 24-hour urinary excretion of cGMP was measured with a (125)I-labeled cGMP radioimmunoassay and was adjusted for urinary creatinine excretion (nmol/mmol creatinine).
  
  
  RESULTS
  Aging was positively associated with urinary excretion of cGMP for both sexes. Postmenopausal women excreted significantly less urinary cGMP than premenopausal women after adjustment for age and other cardiovascular risk factors: 48.3+/-0.04 nmol/mmol vs. 61.5+/-0.07 nmol/mmol, p=0.006.
  
  
  CONCLUSIONS
  Our data suggest that cGMP-related vasodilatation is impaired in postmenopausal women.
authors: Public Health, Department of Social and Environmental Medicine, Osaka University, Graduate School of Medicine, Osaka, Japan.
authors: Renzhe
authors: R
authors: Cui
authors: Hiroyasu
authors: H
authors: Iso
authors: Kazumasa
authors: K
authors: Yamagishi
authors: Tetsuya
authors: T
authors: Ohira
authors: Takeshi
authors: T
authors: Tanigawa
authors: Akihiko
authors: A
authors: Kitamura
authors: Masahiko
authors: M
authors: Kiyama
authors: Hironori
authors: H
authors: Imano
authors: Masamitsu
authors: M
authors: Konishi
authors: Takashi
authors: T
authors: Shimamoto
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000652:urine*; D002318:Cardiovascular Diseases / Q000209:etiology; D006152:Cyclic GMP / Q000652:urine*; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008593:Menopause / Q000652:urine*; D008875:Middle Aged; D014664:Vasodilation
chemical_list: D006152:Cyclic GMP