title: Aorto-septal angle in Boxer dogs with subaortic stenosis: an echocardiographic study.
abstract: The present study was designed to determine the aorto-septal angle (AoSA) in Boxer dogs with or without subaortic stenosis (SAS) by using two-dimensional echocardiography. Forty-five Boxer dogs were prospectively included in the study. The AoSA was steeper in the group with SAS than in healthy Boxers with a mean difference of 10 degrees . According to the proposed regression model, the AoSA is associated with SAS in Boxers, particularly because it becomes steeper as SAS severity increases. Several studies in humans demonstrate that small changes in the AoSA produce important changes in septal shear stress, which in turn causes proliferation of the endocardial cells resulting in subaortic obstruction. A definite conclusion about the role of the AoSA on the formation and/or progression of subvalvular lesions in Boxers cannot be drawn from the data analysed due to the transversal nature of the observations.
authors: Dept. Animal Health, Parma University, Via del Taglio, 8, 43100 Parma, Italy. cecilia.quintavalla@unipr.it
authors: Cecilia
authors: C
authors: Quintavalla
authors: Stefano
authors: S
authors: Guazzetti
authors: Antonia
authors: A
authors: Mavropoulou
authors: Claudio
authors: C
authors: Bussadori
mesh_terms: D000818:Animals; D001011:Aorta / Q000033:anatomy & histology* / Q000000981:diagnostic imaging; D001020:Aortic Stenosis, Subvalvular / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000662:veterinary*; D004283:Dog Diseases / Q000000981:diagnostic imaging / Q000503:physiopathology*; D004285:Dogs; D004452:Echocardiography / Q000662:veterinary; D005260:Female; D006346:Heart Septum / Q000033:anatomy & histology* / Q000000981:diagnostic imaging; D008297:Male; D011446:Prospective Studies; D012720:Severity of Illness Index