Does COLIA1 SP1-binding site polymorphism predispose women to pelvic organ prolapse?
OBJECTIVE
COLIA1 polymorphism is associated with increased risk for stress urinary incontinence. We hypothesize that a similar association exists with pelvic organ prolapse (POP).


METHODS
Patients with advanced prolapse and healthy controls were evaluated by interview, validated questionnaires, and pelvic examination. DNA was extracted from peripheral blood, and polymerase chain reaction was performed to determine the presence or absence of the polymorphism. Power calculation indicated the need for 36 patients in each arm.


RESULTS
The prevalence of the polymorphic heterozygous genotype (GT) in the study and control groups was 33.3% and 19.4%, respectively, leading to an odds ratio of 1.75. This difference, however, did not reach statistical significance (p = 0.27).


CONCLUSIONS
The COLIA1 polymorphism was not significantly associated with increased risk for POP.
Feiner
Benjamin
B
Division of Urogynecology and Reconstructive Pelvic Surgery, Department of Obstetrics and Gynecology, Carmel Medical Center, Technion University Medical School, Haifa, Israel. feiner@tx.technion.ac.il
Fares
Fuad
F
Azam
Nail
N
Auslender
Ron
R
David
Miriam
M
Abramov
Yoram
Y
D000368:Aged; D016022:Case-Control Studies; D024042:Collagen Type I / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D014596:Uterine Prolapse / Q000235:genetics*
D024042:Collagen Type I