Enhanced imaging in low dose electron microscopy using electron counting.
We compare the direct electron imaging performance at 120keV of a monolithic active pixel sensor (MAPS) operated in a conventional integrating mode with the performance obtained when operated in a single event counting mode. For the combination of sensor and incident electron energy used here, we propose a heuristic approach with which to process the single event images in which each event is renormalised to have an integrated weight of unity. Using this approach we find enhancements in the Nyquist frequency modulation transfer function (MTF) and detective quantum efficiency (DQE) over the corresponding integrating mode values by factors of 8 and 3, respectively.
McMullan
G
G
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK. gm2@mrc-lmb.cam.ac.uk
Clark
A T
AT
Turchetta
R
R
Faruqi
A R
AR
D003198:Computer Simulation; D004583:Electrons; D008854:Microscopy, Electron / Q000379:methods*