title: Genetic properties of the maize nested association mapping population.
abstract: Maize genetic diversity has been used to understand the molecular basis of phenotypic variation and to improve agricultural efficiency and sustainability. We crossed 25 diverse inbred maize lines to the B73 reference line, capturing a total of 136,000 recombination events. Variation for recombination frequencies was observed among families, influenced by local (cis) genetic variation. We identified evidence for numerous minor single-locus effects but little two-locus linkage disequilibrium or segregation distortion, which indicated a limited role for genes with large effects and epistatic interactions on fitness. We observed excess residual heterozygosity in pericentromeric regions, which suggested that selection in inbred lines has been less efficient in these regions because of reduced recombination frequency. This implies that pericentromeric regions may contribute disproportionally to heterosis.
authors: United States Department of Agriculture-Agriculture Research Service (USDA-ARS), USA. mcmullenm@missouri.edu
authors: Michael D
authors: MD
authors: McMullen
authors: Stephen
authors: S
authors: Kresovich
authors: Hector Sanchez
authors: HS
authors: Villeda
authors: Peter
authors: P
authors: Bradbury
authors: Huihui
authors: H
authors: Li
authors: Qi
authors: Q
authors: Sun
authors: Sherry
authors: S
authors: Flint-Garcia
authors: Jeffry
authors: J
authors: Thornsberry
authors: Charlotte
authors: C
authors: Acharya
authors: Christopher
authors: C
authors: Bottoms
authors: Patrick
authors: P
authors: Brown
authors: Chris
authors: C
authors: Browne
authors: Magen
authors: M
authors: Eller
authors: Kate
authors: K
authors: Guill
authors: Carlos
authors: C
authors: Harjes
authors: Dallas
authors: D
authors: Kroon
authors: Nick
authors: N
authors: Lepak
authors: Sharon E
authors: SE
authors: Mitchell
authors: Brooke
authors: B
authors: Peterson
authors: Gael
authors: G
authors: Pressoir
authors: Susan
authors: S
authors: Romero
authors: Marco
authors: M
authors: Oropeza Rosas
authors: Stella
authors: S
authors: Salvo
authors: Heather
authors: H
authors: Yates
authors: Mark
authors: M
authors: Hanson
authors: Elizabeth
authors: E
authors: Jones
authors: Stephen
authors: S
authors: Smith
authors: Jeffrey C
authors: JC
authors: Glaubitz
authors: Major
authors: M
authors: Goodman
authors: Doreen
authors: D
authors: Ware
authors: James B
authors: JB
authors: Holland
authors: Edward S
authors: ES
authors: Buckler
mesh_terms: D000483:Alleles; D002503:Centromere / Q000235:genetics; D002874:Chromosome Mapping; D032461:Chromosomes, Plant / Q000235:genetics*; D003433:Crosses, Genetic; D004843:Epistasis, Genetic; D035264:Flowers / Q000235:genetics / Q000254:growth & development; D014644:Genetic Variation; D018745:Genome, Plant; D006579:Heterozygote; D006823:Hybrid Vigor; D007178:Inbreeding; D015810:Linkage Disequilibrium; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D040641:Quantitative Trait Loci; D019655:Quantitative Trait, Heritable; D011995:Recombination, Genetic; D012641:Selection, Genetic; D003313:Zea mays / Q000145:classification / Q000235:genetics* / Q000502:physiology