[Study on the tissue distribution of berberine from Rhizoma Coptidis and compatibility with Rhizoma Coptidis and Cortex Cinnamomi in rats].
OBJECTIVE
To study the effects of Rhizoma Coptidis extracts and Rhizoma Coptidis and Cortex Cinnamomi extracts on the distribution of terberine in rats' tissues.


METHODS
The rats were intragastrically given the two different extracts. HPLC was used to determine the concentration of berberine in rats' tissues and the sample was extracted by liquid-liquid extraction method.


RESULTS
At the same time, with the same gavage of the three extracts, the trend of the berberine in rats was: the concentration of Rhizoma Coptidis and Cortex Cinnamomi extracts > the concentration of Rhizoma Coptidis extracts.


CONCLUSIONS
Berberine can be detected in intestinal, stomach, colon, pancreatic, heart, kidney, liver, spleen, lung, testicular, uterus, especially the gastrointestinal system with higher concentration, so berberine has a wide range of distribution in vivo.
Yan
Qiao-Na
QN
Pharmacy College, Liaoning University of TCM, Dalian 116600, China. yqn-413@163.com
Zhang
Shuo
S
Zhang
Zhen-Qiu
ZQ
D000818:Animals; D001599:Berberine / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D039323:Coptis / Q000737:chemistry; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D005260:Female; D041981:Gastrointestinal Tract / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000378:metabolism; D019770:Lauraceae / Q000737:chemistry; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008297:Male; D024301:Plant Bark / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D014018:Tissue Distribution
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D001599:Berberine