Neutropenic enterocolitis.
Neutropenic enterocolitis, also known as typhlitis or ileocecal syndrome, is a rare but important complication of neutropenia associated with malignancy. It occurs as a result of chemotherapeutic damage to the intestinal mucosa in the context of an absolute neutropenia, and can rapidly progress to intestinal perforation, multisystem organ failure, and sepsis. Presenting signs and symptoms may include fever, abdominal pain, nausea, vomiting, and diarrhea. Rapid identification by emergency physicians and timely, aggressive medical and/or surgical intervention are the cornerstones of survival for these patients.
Cloutier
Robert L
RL
Department of Emergency Medicine, Doernbecher Children's Hospital, Oregon Health & Science University, Portland, OR 97239, USA. cloutier@ohsu.edu
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000009:adverse effects; D003952:Diagnostic Imaging; D004636:Emergency Service, Hospital; D044504:Enterocolitis, Neutropenic / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy*; D006801:Humans; D007422:Intestines / Q000000981:diagnostic imaging; D009369:Neoplasms / Q000150:complications / Q000188:drug therapy; D011859:Radiography; D012307:Risk Factors; D014463:Ultrasonography
D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents