title: Effects of bicarbonate/lactate dialysis solution on the inflammatory response of spontaneous peritonitis in rats undergoing chronic peritoneal dialysis.
abstract: BACKGROUND
  We evaluated the incidence of spontaneous peritonitis as well as the local inflammatory response and macroscopic changes in the peritoneum during the use of a bicarbonate/lactate-buffered (P) solution in comparison to conventional (D) solutions in rats on chronic peritoneal dialysis.
  
  
  METHODS
  Sixty-three male Wistar rats were implanted with peritoneal catheters. After 7 days, the animals were randomly divided into 2 experimental groups (32 rats in D, 31 rats in P) and infused twice daily over the following 4 weeks.
  
  
  RESULTS
  After 14 and 23 days, rats dialyzed with D had a higher peritonitis rate than those dialyzed with P. The median number of days until peritonitis occurred was 22 days for the rats in the D group and 29 days for the rats in the P group. Spontaneously infected rats dialyzed with the D solution had higher scores for adhesion formation.
  
  
  CONCLUSIONS
  In this animal model, dialysis with P delayed the time to the 1st infection, reduced the overall peritonitis rate and reduced peritonitis-associated peritoneal adhesion formation during chronic peritoneal dialysis.
authors: Division of Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden. kpawlac@amp.edu.pl
authors: Krzysztof
authors: K
authors: Pawlaczyk
authors: Clifford J
authors: CJ
authors: Holmes
authors: Stanislaw
authors: S
authors: Czekalski
authors: Andrzej
authors: A
authors: Breborowicz
authors: Bengt
authors: B
authors: Lindholm
mesh_terms: D000818:Animals; D001639:Bicarbonates / Q000494:pharmacology*; D015314:Dialysis Solutions / Q000494:pharmacology*; D007249:Inflammation / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D007773:Lactates / Q000494:pharmacology*; D008297:Male; D010530:Peritoneal Dialysis / Q000009:adverse effects*; D010537:Peritoneum / Q000378:metabolism / Q000473:pathology; D010538:Peritonitis / Q000209:etiology / Q000378:metabolism* / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D001639:Bicarbonates; D015314:Dialysis Solutions; D007773:Lactates