title: Sequential outcome following autologous chondrocyte implantation of the knee: a six-year follow-up.
abstract: This prospective six-year longitudinal study reviews the clinical outcome of patients undergoing autologous chondrocyte implantation (ACI) and a porcine type I/III collagen membrane cover for deep chondral defects of the knee. We present 57 patients (31 male, 26 female) with a mean age of 31.6 years (range 15-51 years) that have undergone ACI since July 1998. The mean size of the defect was 3.14 cm(2) (range 1.0-7.0 cm(2)). All patients were assessed annually using seven independent validated clinical rating scores with the data analysed using ANOVA. ACI using a porcine type I/III collagen membrane cover produced statistically significant improvements (p < 0.001), maintained for up to six years, in knee symptoms compared to pre-operative levels. This study provides evidence of the medium-term benefit achieved by transplanting autologous chondrocytes to osteochondral defects.
authors: The Royal National Orthopaedic Hospital, Stanmore, UK. benedictrogers@hotmail.com
authors: Benedict A
authors: BA
authors: Rogers
authors: Lee A
authors: LA
authors: David
authors: Tim W R
authors: TW
authors: Briggs
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D001182:Arthroscopy; D001705:Bioprosthesis; D002358:Cartilage, Articular / Q000293:injuries / Q000473:pathology / Q000601:surgery*; D017690:Cell Transplantation / Q000379:methods; D019902:Chondrocytes / Q000473:pathology / Q000637:transplantation*; D024042:Collagen Type I / Q000627:therapeutic use; D024061:Collagen Type III / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007718:Knee Injuries / Q000473:pathology / Q000534:rehabilitation / Q000601:surgery*; D007719:Knee Joint / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D007720:Knee Prosthesis; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D020127:Recovery of Function; D013552:Swine; D014182:Transplantation, Autologous; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D024042:Collagen Type I; D024061:Collagen Type III