title: Decreased placental oxygenation capacity in pre-eclampsia: clinical application of a novel index of placental function preformed at the time of delivery.
abstract: OBJECTIVE
  We have previously described placental oxygenation capacity as an index of placental function. The aim of this study was to utilize this test to evaluate placental gas exchange capacity in pre-eclampsia and fetal growth restriction (FGR).
  
  
  METHODS
  Two nested case-control studies were conducted between: (i) pre-eclamptic appropriate-for-gestational-age fetus (AGA) and non-pre-eclamptic AGA; and (ii) pre-eclamptic FGR and non-pre-eclamptic FGR based on gestational age match. Umbilical A-V gas differences were compared between groups.
  
  
  RESULTS
  Pre-eclamptic AGA was associated with smaller A-V pO(2) and A-V pCO(2) differences compared to non-pre-eclampsia (A-V pO(2), 7.1+/-3.8 mm Hg vs. 11.3+/-5.9 mm Hg, P=0.001; A-V pCO(2), 7.8+/-5.7 mm Hg vs. 10.7+/- 5.9 mm Hg, P=0.01). Pre-eclamptic FGR was associated with smaller A-V pO(2) and A-V pCO(2) differences compared to non-pre-eclampsia (A-V pO(2), 6.6+/-3.1 mm Hg vs. 10.8+/-8.1 mm Hg, P<0.001; 6.7+/-4.5 mm Hg vs. 10.9+/-10.3 mm Hg, P=0.044). Pre-eclamptic FGR also had significantly lower venous pO(2) but not arterial pO(2) (Venous pO(2), 20.3+/-6.3 mm Hg vs. 25.4+/-11.9 mm Hg, P=0.003).
  
  
  CONCLUSIONS
  Pre-eclampsia decreases the placental oxygenation capacity as measured by the umbilical arterial-venous oxygen difference.
authors: Department of Obstetrics, Gynecology, and Reproductive Science, University of Maryland School of Medicine, Baltimore, MD 21201, USA. kmats001@umaryland.edu
authors: Koji
authors: K
authors: Matsuo
authors: Andrew M
authors: AM
authors: Malinow
authors: Chris R
authors: CR
authors: Harman
authors: Ahmet A
authors: AA
authors: Baschat
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D036861:Delivery, Obstetric; D005260:Female; D005312:Fetal Blood / Q000378:metabolism; D005317:Fetal Growth Retardation / Q000097:blood / Q000209:etiology; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D008431:Maternal-Fetal Exchange / Q000502:physiology; D010100:Oxygen / Q000097:blood / Q000502:physiology*; D036801:Parturition / Q000097:blood / Q000502:physiology*; D010920:Placenta / Q000098:blood supply / Q000503:physiopathology*; D011225:Pre-Eclampsia / Q000097:blood / Q000503:physiopathology*; D011247:Pregnancy
chemical_list: D010100:Oxygen