Efficient synthesis of flavanone glucuronides.
The first efficient synthesis of flavanone glucuronides as potential human metabolites is described. The synthetic strategy is based on acetyl protection, followed by a combination of chemical and enzymatic deprotection steps. As an example, the method is applied to a synthesis of 7,4'-di-O-methyleriodictyol 3'-O-beta-d-glucuronide. The aglycone is a flavanone naturally present in tarragon spice ( Artemisia dracunculus ) as well as in various Chinese, Brazilian, and Malaysian medicinal plants.
Boumendjel
Ahcene
A
Départment de Pharmacochimie Moléculaire, UMR 5063, ICMG-FR 2607, Grenoble University, Grenoble Cedex 9, France.
Blanc
Madeleine
M
Williamson
Gary
G
Barron
Denis
D
D002617:Chemical Industry / Q000379:methods*; D044950:Flavanones / Q000138:chemical synthesis* / Q000737:chemistry; D020719:Glucuronides / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
D044950:Flavanones; D020719:Glucuronides; C028610:flavanone