Combined use of chiral ionic liquid and cyclodextrin for MEKC: Part I. Simultaneous enantioseparation of anionic profens.
The enantiomers of five profen drugs were simultaneously separated by MEKC with the combined use of 2,3,6-tri-O-methyl-beta-cyclodextrin and chiral cationic ionic liquid, N-undecenoxy-carbonyl-L-leucinol bromide, which formed micelles in aqueous buffers. Enantioseparations of these profen drugs were optimized by varying the chain length and concentration of the IL surfactant using a standard recipe containing 35 mM 2,3,6-tri-O-methyl-beta-cyclodextrin, 5 mM sodium acetate at pH 5.0. The batch-to-batch reproducibility of N-undecenoxy-carbonyl-L-leucinol bromide was tested and found to have no significant impact in terms of enantiomeric resolution, efficiency, and migration time. Finally, this method was successfully applied for the quantitative determination of ibuprofen in pharmaceutical tablets.
Wang
Bin
B
Department of Chemistry, Center of Biotechnology and Drug Design, Georgia State University, Atlanta, GA 30303, USA.
He
Jun
J
Bianchi
Victoria
V
Shamsi
Shahab A
SA
D002412:Cations / Q000737:chemistry; D020374:Chromatography, Micellar Electrokinetic Capillary / Q000379:methods*; D052578:Ionic Liquids / Q000737:chemistry*; D008968:Molecular Conformation; D004364:Pharmaceutical Preparations; D010666:Phenylpropionates / Q000302:isolation & purification*; D015203:Reproducibility of Results; D013237:Stereoisomerism; D013501:Surface-Active Agents / Q000737:chemistry*; D047392:beta-Cyclodextrins / Q000737:chemistry*
D002412:Cations; D052578:Ionic Liquids; D004364:Pharmaceutical Preparations; D010666:Phenylpropionates; D013501:Surface-Active Agents; D047392:beta-Cyclodextrins; C000609658:heptakis(2,3,6-tri-O-methyl)-beta-cyclodextrin