Catalytic enantioselective synthesis of alpha,beta-diamino acid derivatives.
Highly enantio- and diastereoselective organocatalytic Mannich additions of alpha-isothiocyanato imides to sulfonyl imines are reported. Enantiomerically enriched syn-alpha,beta-diamino acid derivatives can be obtained in excellent yields using catalyst loadings as low as 0.25 mol %.
Li
Le
L
Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA.
Ganesh
Madhu
M
Seidel
Daniel
D
D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry*; D002384:Catalysis; D007094:Imides / Q000737:chemistry; D007097:Imines / Q000737:chemistry; D017879:Isothiocyanates / Q000737:chemistry; D008352:Mannich Bases / Q000737:chemistry; D013237:Stereoisomerism; D013379:Substrate Specificity; D013696:Temperature
D000596:Amino Acids; D007094:Imides; D007097:Imines; D017879:Isothiocyanates; D008352:Mannich Bases; C037152:isothiocyanic acid