Predictive factors associated with the reversibility of post-transplantation diabetes mellitus following liver transplantation.
Post-transplantation diabetes mellitus (PTDM) is reversible in a considerable number of patients. We examined the prevalence and predictive factors of transient PTDM following liver transplantation. Forty-two of 74 PTDM patients showed the clinical features of transient PTDM. Compared with the persistent PTDM patients, they were characterized by younger age at the time of transplantation (49+/-7 vs. 53+/-8 yr, P<0.05), longer time before the development of PTDM (44+/-59 vs. 13+/-20 days, P<0.05), lower rate of hepatitis c virus seropositivity (0.0 vs. 9.4%, P<0.05), and use of mycophenolate mofetil (59.5 vs. 28.1%, P<0.05). Among these risk factors, age at the time of transplantation is the single independent predictive factor associated with the reversibility of PTDM.
Ahn
Hwa Young
HY
Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
Cho
Young Min
YM
Yi
Nam-Joon
NJ
Suh
Kyung Suk
KS
Lee
Kuhn Uk
KU
Park
Kyong Soo
KS
Kim
Seong Yeon
SY
Lee
Hong Kyu
HK
D000328:Adult; D000367:Age Factors; D003920:Diabetes Mellitus / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D016174:Hepacivirus / Q000302:isolation & purification; D006801:Humans; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009173:Mycophenolic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D011237:Predictive Value of Tests; D015995:Prevalence; D012307:Risk Factors
D009173:Mycophenolic Acid