Immobilized monolithic enzyme reactors for application in proteomics and pharmaceutics.
The use of monolithic supports for a wide variety of applications has rapidly expanded during the past few years. The examples for applications of monoliths presented herein show that the chromatographic performance of bioreactors and affinity media prepared from monolithic media is superior to that of conventional particle-based systems. The ease of fabrication and modification combined with the long lifetime of the monolithic columns and their potential to be used in fully automated analytical systems make them attractive tools for an increasing number of applications.
Spross
Jens
J
Department of Pharmaceutical Chemistry & Bioanalytics, Institute of Pharmacy, Martin-Luther-Universität Halle-Wittenberg, Wolfgang-Langenbeck-Strasse 4, 06120, Halle, Saale, Germany.
Sinz
Andrea
A
D019149:Bioreactors; D002845:Chromatography / Q000295:instrumentation*; D004800:Enzymes, Immobilized / Q000737:chemistry*; D016062:Porosity; D011485:Protein Binding; D040901:Proteomics / Q000295:instrumentation* / Q000379:methods; D012117:Resins, Synthetic / Q000737:chemistry*; D013678:Technology, Pharmaceutical / Q000295:instrumentation* / Q000379:methods
D004800:Enzymes, Immobilized; D012117:Resins, Synthetic