Effects of bicarbonate/lactate dialysis solution on the inflammatory response of spontaneous peritonitis in rats undergoing chronic peritoneal dialysis.
BACKGROUND
We evaluated the incidence of spontaneous peritonitis as well as the local inflammatory response and macroscopic changes in the peritoneum during the use of a bicarbonate/lactate-buffered (P) solution in comparison to conventional (D) solutions in rats on chronic peritoneal dialysis.


METHODS
Sixty-three male Wistar rats were implanted with peritoneal catheters. After 7 days, the animals were randomly divided into 2 experimental groups (32 rats in D, 31 rats in P) and infused twice daily over the following 4 weeks.


RESULTS
After 14 and 23 days, rats dialyzed with D had a higher peritonitis rate than those dialyzed with P. The median number of days until peritonitis occurred was 22 days for the rats in the D group and 29 days for the rats in the P group. Spontaneously infected rats dialyzed with the D solution had higher scores for adhesion formation.


CONCLUSIONS
In this animal model, dialysis with P delayed the time to the 1st infection, reduced the overall peritonitis rate and reduced peritonitis-associated peritoneal adhesion formation during chronic peritoneal dialysis.
Pawlaczyk
Krzysztof
K
Division of Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden. kpawlac@amp.edu.pl
Holmes
Clifford J
CJ
Czekalski
Stanislaw
S
Breborowicz
Andrzej
A
Lindholm
Bengt
B
D000818:Animals; D001639:Bicarbonates / Q000494:pharmacology*; D015314:Dialysis Solutions / Q000494:pharmacology*; D007249:Inflammation / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D007773:Lactates / Q000494:pharmacology*; D008297:Male; D010530:Peritoneal Dialysis / Q000009:adverse effects*; D010537:Peritoneum / Q000378:metabolism / Q000473:pathology; D010538:Peritonitis / Q000209:etiology / Q000378:metabolism* / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar
D001639:Bicarbonates; D015314:Dialysis Solutions; D007773:Lactates