Raf-1 and squamous cell carcinoma: Rok-ing the boat.
Squamous cell carcinoma (SCC) is the second most common form of nonmelanoma skin cancer. In this issue of Cancer Cell, Ehrenreiter et al. unveil a critical role for the Raf-1/Rok-alpha interaction in the pathogenesis of SCCs, thus paving the way for the development of therapeutic modalities to treat this malignancy.
Grabocka
Elda
E
Department of Biochemistry, New York University School of Medicine, New York, NY 10016, USA.
Bar-Sagi
Dafna
D
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000201:enzymology* / Q000235:genetics / Q000473:pathology; D002454:Cell Differentiation; D049109:Cell Proliferation; D015603:Keratinocytes / Q000201:enzymology / Q000473:pathology; D051379:Mice; D019908:Proto-Oncogene Proteins c-raf / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction; D012878:Skin Neoplasms / Q000201:enzymology* / Q000235:genetics / Q000473:pathology; D054460:rho-Associated Kinases / Q000378:metabolism*
D019908:Proto-Oncogene Proteins c-raf; C515855:Rock2 protein, mouse; D054460:rho-Associated Kinases