Enlistment of combinatorial techniques in drug development.
Combinatorial chemistry, in its ability to generate vast arrays of non-peptide and non-oligonucleotide libraries, has had a major impact on the drug discovery effort. The design and generation of a combinatorial library, coupled with the ever important and effective feedback from high-throughput screening and data management, are critical to any drug discovery process. This review will focus on some aspects of computational chemistry, solid-phase organic chemistry and downstream analysis. The emphasis will be on computational aspects of library design and the use of cyclic scaffolds in the context of a focused library for optimization in drug discovery.
Lee
M S
MS
Molecumetics Ltd, Bellevue, WA 98005, USA.
Nakanishi
H
H
Kahn
M
M