Biodegradable poly(epsilon-caprolactone)-poly(ethylene glycol) copolymers as drug delivery system.
Poly(epsilon-caprolactone)-poly(ethylene glycol) (PCL-PEG) copolymers are important synthetic biomedical materials with amphiphilicity, controlled biodegradability, and great biocompatibility. They have great potential application in the fields of nanotechnology, tissue engineering, pharmaceutics, and medicinal chemistry. This review introduced several aspects of PCL-PEG copolymers, including synthetic chemistry, PCL-PEG micro/nanoparticles, PCL-PEG hydrogels, and physicochemical and toxicological properties.
Wei
XiaWei
X
State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
Gong
ChangYang
C
Gou
MaLing
M
Fu
ShaoZhi
S
Guo
QingFa
Q
Shi
Shuai
S
Luo
Feng
F
Guo
Gang
G
Qiu
LiYan
L
Qian
ZhiYong
Z
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D001673:Biodegradation, Environmental; D004337:Drug Carriers; D005026:Ethylene Glycols / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D006801:Humans; D020100:Hydrogels / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry; D011091:Polyesters / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity
D001672:Biocompatible Materials; D004337:Drug Carriers; D005026:Ethylene Glycols; D020100:Hydrogels; D011091:Polyesters; C476300:poly(epsilon-caprolactone)-b-poly(ethylene glycol)