title: Low-molecular-weight heparin-induced skin necrosis: about 2 cases.
abstract: Heparin-induced skin necrosis is an infrequent condition, complicating unfractionated heparin and more rarely low-molecular-weight heparin administration. Like heparin-induced thrombocytopenia, it is associated with the presence of anti-PF4 antibodies. After reporting 2 observations, we briefly review the clinical features and management of this condition. Early recognition is of the utmost importance since heparin-induced skin necrosis can be associated with HIT, a potentially lethal disorder.
authors: Departement of General Internal Medicine, Cliniques Universitaires Saint Luc, UCL, Bruxelles, Belgium.
authors: J C
authors: JC
authors: Yombi
authors: L
authors: L
authors: Belkhir
authors: T
authors: T
authors: De Baere
authors: J E
authors: JE
authors: Dubuc
authors: P
authors: P
authors: Hainaut
mesh_terms: D000368:Aged; D000925:Anticoagulants / Q000009:adverse effects*; D005260:Female; D006495:Heparin, Low-Molecular-Weight / Q000009:adverse effects*; D006801:Humans; D008875:Middle Aged; D009336:Necrosis / Q000139:chemically induced / Q000473:pathology / Q000628:therapy; D012867:Skin / Q000187:drug effects* / Q000473:pathology*
chemical_list: D000925:Anticoagulants; D006495:Heparin, Low-Molecular-Weight