title: Novel CXCR3 antagonists with a piperazinyl-piperidine core.
abstract: High-throughput screening of an encoded combinatorial aryl piperazine library led to the identification of a novel series of potent piperazinyl-piperidine based CXCR3 antagonists. Analogs of the initial hit were synthesized via solid and solution phase methods to probe the influence of structure on the CXCR3 binding of these molecules. Various functional groups were found to contribute to the overall potency and essential molecular features were identified.
authors: Ligand Pharmaceuticals, 3000 Eastpark Boulevard, Cranbury, NJ 08512, USA. bmcguinness@ligand.com
authors: Brian F
authors: BF
authors: McGuinness
authors: Carolyn DiIanni
authors: CD
authors: Carroll
authors: Lisa Guise
authors: LG
authors: Zawacki
authors: Guizhen
authors: G
authors: Dong
authors: Cangming
authors: C
authors: Yang
authors: Doug W
authors: DW
authors: Hobbs
authors: Biji
authors: B
authors: Jacob-Samuel
authors: James W
authors: JW
authors: Hall
authors: Chung-Her
authors: CH
authors: Jenh
authors: Joseph A
authors: JA
authors: Kozlowski
authors: Gopinadhan N
authors: GN
authors: Anilkumar
authors: Stuart B
authors: SB
authors: Rosenblum
mesh_terms: D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D020650:Combinatorial Chemistry Techniques; D006801:Humans; D010879:Piperazines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D010880:Piperidines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D054367:Receptors, CXCR3 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D000893:Anti-Inflammatory Agents; D010879:Piperazines; D010880:Piperidines; D054367:Receptors, CXCR3