Infection by the Sylvio X10/4 clone of Trypanosoma cruzi: relevance of a low-virulence model of Chagas' disease.
The physiopathology of Chagas' disease has been largely defined in murine infections with virulent strains which partially represent parasite diversity. This report reviews our studies with Sylvio X10/4 parasites, a Trypanosoma cruzi clone that induces no acute phase but in C3H/He mice leads to chronic myocarditis resembling the human disease.
Marinho
Cláudio R F
CR
Department of Immunology, Biomedical Sciences Institute, University of São Paulo, Av. Professor Lineu Prestes, 1730, São Paulo, SP, CEP-05508-000, Brazil.
Nuñez-Apaza
Luis N
LN
Bortoluci
Karina R
KR
Bombeiro
André L
AL
Bucci
Daniella Z
DZ
Grisotto
Marcos G
MG
Sardinha
Luiz R
LR
Jorquera
Christian E
CE
Lira
Sergio
S
Lima
Maria Regina D'Império
MR
Alvarez
José M
JM
D000818:Animals; D014355:Chagas Disease / Q000276:immunology / Q000469:parasitology*; D002908:Chronic Disease; D004195:Disease Models, Animal; D006790:Host-Parasite Interactions; D051379:Mice; D018512:Parasitemia / Q000276:immunology / Q000469:parasitology; D014349:Trypanosoma cruzi / Q000472:pathogenicity / Q000502:physiology*