title: Determination of optimal dosage and delay time for computed tomographic lymphography after percutaneous injection of Iohexol into popliteal lymph nodes in dogs.
abstract: The purposes of this study were to determine the optimal dose and delay time for lymphography by injection of Iohexol into popliteal lymph nodes and to assess images of computed tomography by the established protocol. Three different doses (30, 60 and 90 mgI/kg) of water-soluble iodinated contrast medium were injected into 15 popliteal lymph nodes of 10 adult beagles, and fluoroscopy was performed. Filling and duration of contrast media and the number of visible ducts from popliteal lymph nodes to the thoracic duct and its branches were recorded. CT lymphography was performed, and the number of visible thoracic ducts was compared with that found by radiographic lymphography. Radiographs obtained between 130 and 800 seconds after injection of contrast medium provided a detailed view of the thoracic duct. The dose of 60 mgI/kg was determined to enable quality diagnostic imaging without extranodal leakage in radiographic lymphography. There was no significant difference in the number of thoracic ducts between the two modalities at each anatomic location. However, CT lymphography provided images of the thoracic duct with better spatial resolution and without superimposition of surrounding tissue. The present study provides an adequate delay time and injection for identification of the canine thoracic duct, and therefore, this technique could be applied to diagnosis of disease associated with chest lymphatic drainage.
authors: Veterinary Medical Center , College of Veterinary Medicine, Chungbuk National University, Chungbuk, Republic of Korea.
authors: Hyeyoung
authors: H
authors: Chun
authors: Hangmyo
authors: H
authors: Cho
authors: Haengbok
authors: H
authors: Cheon
authors: Juhyung
authors: J
authors: Kim
authors: Taehun
authors: T
authors: Kim
authors: Ji-Houn
authors: JH
authors: Kang
authors: Gonhyung
authors: G
authors: Kim
authors: Youngwon
authors: Y
authors: Lee
authors: Hojung
authors: H
authors: Choi
authors: Heechun
authors: H
authors: Lee
authors: Dongwoo
authors: D
authors: Chang
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000008:administration & dosage / Q000494:pharmacology; D004285:Dogs / Q000033:anatomy & histology*; D004305:Dose-Response Relationship, Drug; D007472:Iohexol / Q000008:administration & dosage* / Q000494:pharmacology*; D008198:Lymph Nodes / Q000000981:diagnostic imaging*; D014057:Tomography, X-Ray Computed / Q000662:veterinary*
chemical_list: D003287:Contrast Media; D007472:Iohexol