title: Mitochondrial turnover and aging of long-lived postmitotic cells: the mitochondrial-lysosomal axis theory of aging.
abstract: It is now generally accepted that aging and eventual death of multicellular organisms is to a large extent related to macromolecular damage by mitochondrially produced reactive oxygen species, mostly affecting long-lived postmitotic cells, such as neurons and cardiac myocytes. These cells are rarely or not at all replaced during life and can be as old as the whole organism. The inherent inability of autophagy and other cellular-degradation mechanisms to remove damaged structures completely results in the progressive accumulation of garbage, including cytosolic protein aggregates, defective mitochondria, and lipofuscin, an intralysosomal indigestible material. In this review, we stress the importance of crosstalk between mitochondria and lysosomes in aging. The slow accumulation of lipofuscin within lysosomes seems to depress autophagy, resulting in reduced turnover of effective mitochondria. The latter not only are functionally deficient but also produce increased amounts of reactive oxygen species, prompting lipofuscinogenesis. Moreover, defective and enlarged mitochondria are poorly autophagocytosed and constitute a growing population of badly functioning organelles that do not fuse and exchange their contents with normal mitochondria. The progress of these changes seems to result in enhanced oxidative stress, decreased ATP production, and collapse of the cellular catabolic machinery, which eventually is incompatible with survival.
authors: Department of Clinical Pathology and Cytology, Karolinska University Hospital, Huddinge, Stockholm, Sweden. alexei.terman@ki.se
authors: Alexei
authors: A
authors: Terman
authors: Tino
authors: T
authors: Kurz
authors: Marian
authors: M
authors: Navratil
authors: Edgar A
authors: EA
authors: Arriaga
authors: Ulf T
authors: UT
authors: Brunk
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology; D001343:Autophagy / Q000502:physiology; D016922:Cellular Senescence / Q000502:physiology*; D006801:Humans; D008062:Lipofuscin / Q000502:physiology; D008247:Lysosomes / Q000473:pathology / Q000502:physiology*; D051379:Mice; D008928:Mitochondria / Q000473:pathology / Q000502:physiology*; D008938:Mitosis; D018384:Oxidative Stress / Q000502:physiology; D049070:Protease La / Q000502:physiology; D051381:Rats; D017382:Reactive Oxygen Species / Q000633:toxicity
chemical_list: D008062:Lipofuscin; D017382:Reactive Oxygen Species; D049070:Protease La