Biomaterials for promoting brain protection, repair and regeneration.
Biomaterials are likely to have an increasingly important role in the treatment of nervous system disorders. Recently developed biomaterials can enable and augment the targeted delivery of drugs or therapeutic proteins to the brain, allow cell or tissue transplants to be effectively delivered to the brain and help to rebuild damaged circuits. Similarly, biomaterials are being used to promote regeneration and to repair damaged neuronal pathways in combination with stem cell therapies. Many of these approaches are gaining momentum because nanotechnology allows greater control over material-cell interactions that induce specific developmental processes and cellular responses including differentiation, migration and outgrowth.
Orive
Gorka
G
Laboratory of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of the Basque Country, 01006, Vitoria, Spain.
Anitua
Eduardo
E
Pedraz
José Luis
JL
Emerich
Dwaine F
DF
D000818:Animals; D001672:Biocompatible Materials / Q000008:administration & dosage* / Q000138:chemical synthesis; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D001927:Brain Diseases / Q000503:physiopathology / Q000517:prevention & control*; D006801:Humans; D036103:Nanotechnology / Q000379:methods / Q000639:trends; D009416:Nerve Regeneration / Q000187:drug effects / Q000502:physiology*; D033581:Stem Cell Transplantation / Q000379:methods / Q000639:trends; D023822:Tissue Engineering / Q000379:methods / Q000639:trends
D001672:Biocompatible Materials