High ratio of myeloid dendritic cells to plasmacytoid dendritic cells in blood of patients with acute coronary syndrome.
BACKGROUND
Dendritic cells (DCs) stimulate T-cells to participate in the inflammatory processes that promote the destruction of vulnerable plaques. The relationship between circulating levels of myeloid DCs (mDCs) and plasmacytoid DCs (pDCs) in patients with acute coronary syndrome (ACS) was evaluated.


RESULTS
Blood samples were obtained from 39 patients with ACS, 41 patients with stable angina pectoris (SAP) and 43 controls. The proportion of mDCs tended to be lower in the ACS group than in the SAP group and controls. Interleukin-12 levels associated with mDCs were significantly higher in the ACS group than in control group. The proportion of pDCs was significantly lower in the ACS groups than in the other two groups. Interferon-alpha levels secreted by pDCs, however, were not significantly different among the 3 groups. The ratio of mDCs to pDCs >or=4 is an important value for distinguishing ACS from SAP patients and control patients through receiver operating characteristic analysis (sensitivity; 85.0%, specificity; 83.4%).


CONCLUSIONS
The ratio of mDCs to pDCs may be a useful marker for detecting ACS and the existence of vulnerable plaques.
Fukunaga
Takashi
T
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Soejima
Hirofumi
H
Irie
Atsushi
A
Fukushima
Ryuichiro
R
Oe
Yoko
Y
Kawano
Hiroaki
H
Sumida
Hitoshi
H
Kaikita
Koichi
K
Sugiyama
Seigo
S
Nishimura
Yasuharu
Y
Ogawa
Hisao
H
D054058:Acute Coronary Syndrome / Q000175:diagnosis / Q000276:immunology*; D000368:Aged; D000369:Aged, 80 and over; D000787:Angina Pectoris / Q000175:diagnosis / Q000276:immunology*; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D002452:Cell Count; D002469:Cell Separation; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology*; D003937:Diagnosis, Differential; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D016898:Interferon-alpha / Q000097:blood; D018664:Interleukin-12 / Q000097:blood; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D022423:Myeloid Cells / Q000276:immunology*; D016017:Odds Ratio; D011237:Predictive Value of Tests; D012372:ROC Curve; D018570:Risk Assessment; D012421:Rupture
D015415:Biomarkers; D018836:Inflammation Mediators; D016898:Interferon-alpha; D018664:Interleukin-12; D002097:C-Reactive Protein