[Infection-triggered familial or recurrent acute necrotizing encephalopathy].
Acute necrotizing encephalopathy (ANE) presents in children after common viral infections. Most cases of ANE are non-familial and non-recurrent and have been mainly reported in Asian patients, although ANE affects children worldwide. Recently, missense mutations in the gene encoding the nuclear pore protein Ran Binding Protein 2 (RANBP2) have been found in several families with familial or recurrent cases of ANE. We describe a Spanish family with familial and recurrent ANE without mutations in RANBP2. Mutations in RANBP2 are not the sole susceptibility alleles for familial or recurrent ANE.
López-Laso
E
E
Servicio de Pediatría, Hospital Universitario Reina Sofía, Córdoba, España. elolaso@gmail.com
Mateos-González
M E
ME
Pérez-Navero
J L
JL
Camino-León
R
R
Briones
P
P
Neilson
D E
DE
D002675:Child, Preschool; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007223:Infant; D007239:Infections; D004684:Leukoencephalitis, Acute Hemorrhagic / Q000235:genetics* / Q000382:microbiology; D008297:Male; D010375:Pedigree; D012008:Recurrence