title: Effect of Mercurius solubilis on the bacteriological response in the alveolitis process in rats.
abstract: OBJECTIVE
  The purpose of this study was to assess the bacteriological response in alveolitis in rats treated with the homeopathic medicine Merc solubilis (Merc sol.) 12 cH.
  
  
  METHODS
  The study was randomized and observer blind. The animals were anesthetized and the upper right incisor extracted resulting in alveolitis. Animals were randomly assigned to groups (n=18/group): Water control, Alcohol control and Merc sol. 12 cH. These groups were subsequently divided into 3 subgroups (n=6/subgroup): Early Euthanasia (EE), Mid Euthanasia (ME) and Late Euthanasia (LE), killed at the 6th, 15th and 21st days respectively. The perialveolar microbiota was collected by swab in Brain Heart Infusion (BHI) for seeding and bacterioscopy. After seeding, the Petri dishes were incubated at 37 degrees C for 48 h.
  
  
  RESULTS
  Quantitative and qualitative changes were observed in the perialveolar microbiota when the groups were compared. Water control and Alcohol control had the highest counts of pathogenic bacteria, the microbiotica of the Merc sol. group remained closer to normal.
  
  
  CONCLUSIONS
  Merc sol. 12 cH did not reduce bacterial growth, but the microbiotica remained within the parameters of normality, obtaining the best results at 21 days after treatment.
authors: Federal University of Pernambuco, Microbiology Division, Laboratory of Immunopathology Keizo-Asami, UFPE, Brazil. flavia_regina_@hotmail.com
authors: Flávia Regina Gonçalves
authors: FR
authors: de Araújo
authors: Célia Maria Machado Barbosa
authors: CM
authors: de Castro
authors: Maiara Santos
authors: MS
authors: Severo
authors: Maria de Fátima Alves
authors: Mde F
authors: Diniz
authors: Marcelo Tavares
authors: MT
authors: Viana
authors: Liriane Baratella
authors: LB
authors: Evêncio
mesh_terms: D000542:Alveolitis, Extrinsic Allergic / Q000188:drug therapy* / Q000382:microbiology*; D000704:Analysis of Variance; D000818:Animals; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage*; D004195:Disease Models, Animal; D006705:Homeopathy / Q000379:methods*; D010497:Pericoronitis / Q000150:complications* / Q000188:drug therapy* / Q000382:microbiology; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D016896:Treatment Outcome
chemical_list: D000891:Anti-Infective Agents, Local