[Arterial hypertension, echocardiographically determined left ventricular hypertrophy and N-terminal pro-B type natriuretic peptide levels in women population aged 56-65 years].
Aim of the study was to investigate relationship between arterial hypertension (AH), left ventricular myocardial mass (LVMM), and levels of N-terminal pro-B type natriuretic peptide (pro-NT BNP) in a population of women inhabitants of Tallinn aged 56-65 years. Of 163 women aged 50-59 years who had participated in epidemiological study in 2000 in 132 measurement of arterial pressure (AP), electrocardiography, echocardiography, complex laboratory diagnostics including determination of pro-NT BNP were repeated in 2007. Most frequent risk factor was AH which was detected in 56.1% of cases. In women with normal AP normal LVMM was noted in 81.1% of cases, while in women with elevated AP normal LVMM was significantly less frequent (28.4%). Only in 5 of 28 women with elevated pro-NT BNP deviations of systolic-diastolic function were observed. Elevated levels of pro-NT BNP were found with almost equal rates among patients with normal and increased LWMM (in 9.1 and 8.3% of cases, respectively). Thus increase of content of pro-NT BNP is of limited significance for diagnosis of left ventricular hypertrophy in women aged 56-65 years without clinical signs of disease.
Shipilova
T
T
Pshenichnikov
I
I
Anier
A
A
Borodin
A
A
Riipulk
E
E
Karaĭ
D
D
Meĭgas
K
K
Kaĭk
Iu
Iu
D000368:Aged; D018450:Disease Progression; D004452:Echocardiography / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000150:complications* / Q000000981:diagnostic imaging; D017379:Hypertrophy, Left Ventricular / Q000097:blood / Q000000981:diagnostic imaging* / Q000209:etiology; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D011379:Prognosis; D011498:Protein Precursors; D012189:Retrospective Studies; D016277:Ventricular Function, Left / Q000502:physiology
D010446:Peptide Fragments; D011498:Protein Precursors; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain