Altered urinary profiles of endogenous steroids in postmenopausal women with adenocarcinoma endometrii.
OBJECTIVE
The potential role of androgen metabolism as co-factors in the development of carcinoma endometrii was investigated.


METHODS
The urinary concentration of 23 androgen, progesterone and corticoid metabolites was quantitatively determined by gas chromatography-mass spectrometry with selected ion-monitoring. We obtained 24-h urine samples from 13 patients with adenocarcinoma endometrii and from 10 age-matched normal female subjects. In the course of the urinary steroid determination, we observed changes in the steroid profiles in the disease examined compared to the same age and same sex control group. Profiling urinary steroids has to give comprehensive information about the synthesis of steroids including the glandular and peripheral steroid metabolisms.


RESULTS
The concentrations of 16-hydroxy- dehydroepiandrosterone, pregnanediol and pregnenediol were not significantly different in the two groups. The concentrations of androsterone, etiocholanolone, 11beta-hydroxy-androsterone, 11beta-hydroxy-etiocholanolone, pregnanetriol, pregnenetriol, tetrahydrocortisone, tetrahydro-11-dehydrocorticosterone, tetrahydro-corticosterone, allo-tetrahydro-corticosterone, tetrahydrocortisol, allo-tetrahydrocortisol, alpha-cortolone, beta-cortolone and alpha-cortol were significantly lower in the postmenopausal women with adenocarcinoma than in the controls.


CONCLUSIONS
The changes in the concentrations of single metabolites point out the important role of steroid group, thus providing help in the recognition and treatment of diseased states.
Bufa
Anita
A
Institute of Bioanalysis, University of Pécs, Honvéd utca 1., Pécs H-7624, Hungary.
Bíró
Ildikó
I
Poór
Viktória
V
Molnár
Gábor
G
Kovács
Kálmán A
KA
Felinger
Attila
A
Jeges
Sára
S
Kilár
Ferenc
F
Gocze
Péter Miklós
PM
D000368:Aged; D018269:Carcinoma, Endometrioid / Q000097:blood / Q000378:metabolism / Q000652:urine*; D016022:Case-Control Studies; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood / Q000652:urine; D016889:Endometrial Neoplasms / Q000097:blood / Q000378:metabolism / Q000652:urine*; D004958:Estradiol / Q000097:blood / Q000378:metabolism / Q000652:urine; D005260:Female; D006801:Humans; D055442:Metabolome; D008875:Middle Aged; D017698:Postmenopause / Q000097:blood / Q000652:urine*; D011374:Progesterone / Q000097:blood / Q000378:metabolism / Q000652:urine; D013256:Steroids / Q000378:metabolism / Q000652:urine*; D016482:Urinalysis
D013256:Steroids; D011374:Progesterone; D004958:Estradiol; D019314:Dehydroepiandrosterone Sulfate