Lipid profile, low-density lipoprotein oxidation and ceruloplasmin in the progeny of families with a positive history of cardiovascular diseases and/or hyperlipidemia.
Fifty-eight healthy progeny (mean age +/- SD 13.9 +/- 7.9 years) of 39 families with a positive history for cardiovascular diseases ([CVD] n = 44) or hyperlipidemia (n = 14) were included in the study and were compared with 30 age-matched control participants, with a negative family history, to evaluate lipid profile, ceruloplasmin (Cp), and lipid peroxidation product (malondialdehyde [MDA]) levels, as well as in vitro copper-induced Low-density lipoprotein (LDL) oxidizability. Mean serum levels of total cholesterol, LDL cholesterol (LDL-C), apolipoprotein B-100, and MDA of the participants were significantly higher than those of the controls. Lag time, an LDL resistance oxidation marker, was lower in the study group and negatively correlated with LDL-C (r = -.437, P < .05) and Cp (r = -.272, P < .05) serum levels. In conclusion, progeny with a positive family history for CVD or hyperlipidemia have an atherogenic lipid profile and increased LDL susceptibility to oxidation. High Cp levels seem to be related to lower resistance of LDL to oxidation.
Makedou
Kali G
KG
Department of Biological Chemistry, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece. kali@med.auth.gr
Mikhailidis
Dimitri P
DP
Makedou
Areti
A
Iliadis
Stavros
S
Kourtis
Anargyros
A
Vavatsi-Christaki
Norma
N
Papageorgiou
Georgios E
GE
D000293:Adolescent; D053299:Apolipoprotein B-100 / Q000097:blood; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000097:blood* / Q000235:genetics; D016022:Case-Control Studies; D002570:Ceruloplasmin / Q000378:metabolism*; D002648:Child; D008078:Cholesterol, LDL / Q000097:blood; D020022:Genetic Predisposition to Disease; D006115:Greece; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood* / Q000235:genetics; D015227:Lipid Peroxidation; D008055:Lipids / Q000097:blood*; D008077:Lipoproteins, LDL / Q000097:blood*; D008315:Malondialdehyde / Q000097:blood; D010375:Pedigree; D055815:Young Adult
D053299:Apolipoprotein B-100; D015415:Biomarkers; D008078:Cholesterol, LDL; D008055:Lipids; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein; D008315:Malondialdehyde; D002570:Ceruloplasmin