title: Distinguishing risk factors for the onset of cravings, withdrawal symptoms and tolerance in novice adolescent smokers.
abstract: OBJECTIVE
  While many studies report determinants of adolescent cigarette smoking, few identify risk factors for nicotine dependence (ND). This study distinguished between risk factors for three hallmarks of ND including cravings, withdrawal symptoms and tolerance.
  
  
  METHODS
  A total of 319 novice smokers were followed every 3 months from first puff on a cigarette until the end of secondary school. Outcomes included time to first report of cravings, withdrawal symptoms and tolerance.
  
  
  RESULTS
  Female sex, inhalation, smoking a whole cigarette, weekly smoking, daily smoking and alcohol use each independently increased the incidence of the onset of cravings. Inhalation, weekly smoking, daily smoking and alcohol use predicted the onset of withdrawal symptoms. Withdrawal symptoms, smoking a whole cigarette, monthly smoking, daily smoking and friends and siblings smoking increased the incidence of the onset of tolerance. None of parental education, impulsivity, novelty seeking, self-esteem, depression, stress, parental smoking, physical activity, or participation in sports teams was associated with the outcomes.
  
  
  CONCLUSIONS
  The hallmarks of early ND are related to intensity and frequency of cigarette use. Avoidance of daily smoking may be particularly important in preventing the onset of ND symptoms and sustained smoking.
authors: Department of Social and Preventive Medicine, University of Montreal, 3875 St Urbain, Montreal, Quebec H2W1V1, Canada.
authors: P
authors: P
authors: Wileyto
authors: J
authors: J
authors: O'Loughlin
authors: M
authors: M
authors: Lagerlund
authors: G
authors: G
authors: Meshefedjian
authors: E
authors: E
authors: Dugas
authors: A
authors: A
authors: Gervais
mesh_terms: D000293:Adolescent; D000294:Adolescent Behavior; D002648:Child; D004361:Drug Tolerance; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D008297:Male; D009538:Nicotine / Q000009:adverse effects*; D011792:Quebec / Q000453:epidemiology; D012907:Smoking / Q000453:epidemiology / Q000523:psychology; D013375:Substance Withdrawal Syndrome / Q000453:epidemiology / Q000209:etiology*; D014029:Tobacco Use Disorder / Q000453:epidemiology / Q000209:etiology*
chemical_list: D009538:Nicotine