title: The pathophysiology of the acute phase of human bartonellosis resembles AIDS.
abstract: Human bartonellosis is a South American anthroponosis caused by Bartonella bacilliformis. The disease has an acute phase characterized by invasion of red blood cells by parasites, and consequent severe anemia; and a chronic phase presenting with benign vascular tumors. During the acute phase, affected individuals are prone to developing opportunistic infections with a variety of organisms similar to the ones seen in AIDS. After antibiotic treatment is instituted, a subgroup of patients may develop atypical symptoms which potentially represent clinical manifestations of the restoration of macrophage function. We speculate that the pathophysiology of the acute phase of human bartonellosis resembles AIDS, with a period of immunosuppression following the infection and later, clinical manifestations of immune reconstitution subsequent to treatment.
authors: Servicio de Enfermedades Infecciosas, Hospital Nacional Dos de Mayo, Parque Historia de la Medicina Peruana s/n, Lima 01, Peru. eticonacrg@gmail.com
authors: Eduardo
authors: E
authors: Ticona
authors: Luz
authors: L
authors: Huaroto
authors: Yuri
authors: Y
authors: Garcia
authors: Lupe
authors: L
authors: Vargas
authors: Miguel G
authors: MG
authors: Madariaga
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000175:diagnosis* / Q000503:physiopathology; D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology; D001474:Bartonella Infections / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology*; D003937:Diagnosis, Differential; D004912:Erythrocytes / Q000166:cytology; D006801:Humans; D007107:Immune System; D007166:Immunosuppressive Agents / Q000494:pharmacology / Q000627:therapeutic use; D007249:Inflammation; D008264:Macrophages / Q000378:metabolism; D008954:Models, Biological; D008962:Models, Theoretical; D013020:South America
chemical_list: D000890:Anti-Infective Agents; D007166:Immunosuppressive Agents