title: Skin and subcutaneous blood flows of very low birth weight infants during the first 3 postnatal days.
abstract: OBJECTIVE
  To determine whether skin and subcutaneous blood flow measurements using a novel laser Doppler flow meter are useful for evaluating the cardiovascular status of very low birth weight (VLBW) infants during the early postnatal period.
  
  
  METHODS
  In eight VLBW infants and eight non-VLBW infants born at Tokyo University Hospital between May 2007 and April 2008, forehead and lower limb skin blood flows were measured continuously for 72 h. Data were averaged every 8 h, and the t-test was used for analysis.
  
  
  RESULTS
  In VLBW infants, forehead blood flow started to increase from the start of measurement to 32 h (16.6 +/- 3.9 ml/min vs. 24.1 +/- 2.1 ml/min; p = 0.002 compared with 8 h) and remained constant thereafter. Lower limb blood flow increased rapidly after 24 h (22.2 +/- 5.5 ml/min vs. 29.5 +/- 5.0 ml/min; p = 0.002 compared with 8 h) and continued increasing thereafter. In contrast, blood flows remained constant in non-VLBW infants.
  
  
  CONCLUSIONS
  The results showed that skin and subcutaneous perfusion in VLBW infants increased spontaneously at around 24 h. Differences in blood flow changes between VLBW and non-VLBW infants demonstrate that these parameters successfully identified physiological changes in tissue perfusion in VLBW infants.
authors: Department of Pediatrics, University of Tokyo, Tokyo, Japan. akio-i@k4.dion.ne.jp
authors: Akio
authors: A
authors: Ishiguro
authors: Takashi
authors: T
authors: Sekine
authors: Satsuki
authors: S
authors: Kakiuchi
authors: Riki
authors: R
authors: Nishimura
authors: Keiji
authors: K
authors: Goishi
authors: Shinya
authors: S
authors: Tsuchida
authors: Hiroshi
authors: H
authors: Ohtsu
authors: Takashi
authors: T
authors: Igarashi
mesh_terms: D002316:Cardiotonic Agents / Q000008:administration & dosage; D016022:Case-Control Studies; D004298:Dopamine / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D005546:Forehead / Q000098:blood supply / Q000502:physiology; D005865:Gestational Age; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D006801:Humans; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight / Q000254:growth & development / Q000502:physiology*; D017078:Laser-Doppler Flowmetry; D036801:Parturition / Q000502:physiology; D012039:Regional Blood Flow / Q000187:drug effects / Q000502:physiology; D012867:Skin / Q000098:blood supply*; D040521:Subcutaneous Tissue / Q000098:blood supply*; D013997:Time Factors
chemical_list: D002316:Cardiotonic Agents; D004298:Dopamine