[Inhibition of adenovirus reproduction in cell culture by specific antibodies].
The capacity of specific antibodies to inhibit the reproduction of homo- and heterologous adenoviruses in Hela cell added to culture medium after virus adsorption was studied. The inhibiting effect of polyclonal antivirus and monospecific antihexone antibodies to homo- and heterologous adenoviruses was shown. The effect was more expressed when using antibodies to homologous antibodies. The intensity of inhibition depended on antibodies concentration in the medium and infecting dose of the virus. Essential reduction of the quantity of infected cells and a decrease of the titer of adenovirus synthesized in the presence of homo- and heterologous antibodies was shown but adenovirus reproduction was not inhibited completely.
Povnytsia
O Iu
OIu
Nosach
L M
LM
Zhovnovata
V L
VL
Zahorodnia
S D
SD
Vantsak
N P
NP
Tokarchuk
L V
LV
Polishchuk
O M
OM
Diachenko
N S
NS
D000260:Adenoviruses, Human / Q000187:drug effects* / Q000276:immunology / Q000502:physiology; D000911:Antibodies, Monoclonal / Q000276:immunology / Q000494:pharmacology*; D000914:Antibodies, Viral / Q000276:immunology; D000918:Antibody Specificity; D036022:Capsid Proteins / Q000276:immunology; D018929:Cell Culture Techniques; D004847:Epithelial Cells / Q000187:drug effects / Q000821:virology*; D006367:HeLa Cells; D006801:Humans; D014779:Virus Replication / Q000187:drug effects*
D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral; D036022:Capsid Proteins; C018315:hexon capsid protein, Adenovirus