title: Restless legs syndrome, rapid eye movement sleep behavior disorder, and hypersomnia in patients with two parkin mutations.
abstract: Parkin gene mutations cause a juvenile parkinsonism. Patients with these mutations may commonly exhibit REM sleep behaviour disorders, but other sleep problems (insomnia, sleepiness, restless legs syndrome) have not been studied. The aim of this study was to evaluate the sleep-wake phenotype in patients with two parkin mutations, compared with patients with idiopathic Parkinson's disease (iPD). Sleep interview and overnight video-polysomnography, followed by multiple sleep latency tests, were assessed in 11 consecutive patients with two parkin mutations (aged 35-60 years, from seven families) and 11 sex-matched patients with iPD (aged 51-65 years). Sleep complaints in the parkin group included insomnia (73% patients versus 45% in the iPD group), restless legs syndrome (45%, versus none in the iPD group, P = 0.04), and daytime sleepiness (45%, versus 54% in the iPD group). Of the parkin patients, 45% had REM sleep without atonia, but only 9% had a definite REM sleep behavior disorder. All sleep measures were similar in the parkin and iPD groups. Two parkin siblings had a central hypersomnia, characterized by mean daytime sleep latencies of 3 min, no sleep onset REM periods, and normal nighttime sleep. Although the patients with two parkin mutations were young, their sleep phenotype paralleled the clinical and polygraphic sleep recording abnormalities reported in iPD, except that restless legs syndrome was more prevalent and secondary narcolepsy was absent.
authors: Unité des Pathologies du sommeil and UMR 975, Université Paris 6, Hôpital Pitié-Salpêtrière, Assistance Publique Hôpitaux de, Paris, France.
authors: Nadège
authors: N
authors: Limousin
authors: Eric
authors: E
authors: Konofal
authors: Elias
authors: E
authors: Karroum
authors: Ebba
authors: E
authors: Lohmann
authors: Ioannis
authors: I
authors: Theodorou
authors: Alexandra
authors: A
authors: Dürr
authors: Isabelle
authors: I
authors: Arnulf
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D006970:Disorders of Excessive Somnolence / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics*; D017286:Polysomnography; D011569:Psychiatric Status Rating Scales; D020187:REM Sleep Behavior Disorder / Q000235:genetics*; D012148:Restless Legs Syndrome / Q000235:genetics*; D044767:Ubiquitin-Protein Ligases / Q000235:genetics*; D055815:Young Adult
chemical_list: D044767:Ubiquitin-Protein Ligases; C111567:parkin protein