[Prevalence of anti-thyroid peroxidase and anti-adrenal 21-hidroxylase in type 1 diabetes patients].
There is still no consensus about the best strategy to screen Addison's disease (AD) in type 1 diabetes mellitus (T1DM) patients.


OBJECTIVE
The aim of this study was to determine the frequency of anti-21-hydroxilase (anti-21OH) in a multiethnic T1DM population and investigate if its presence is associated with any adrenal dysfunction or thyroid autoimmunity.


METHODS
Forty individuals underwent an interview and blood was drawn for anti-thyroperoxidase (anti-TPO), anti-21OH, TSH, free T4 and cortisol measurement.


RESULTS
Anti-21OH was found in 7.5% (n = 3), none with adrenal dysfunction. This antibody was not exclusively seen in patients with anti-TPO (+). Anti-TPO was positive in 25% and associated with higher TSH levels (p = 0.034) and older age (p = 0.009).


CONCLUSIONS
Although the frequency of anti-TPO in this sample was similar to previous studies, a higher prevalence of anti-21-OH was found. However, no coexisting adrenal dysfunction was detected, which does not support universal screening for AD in this group.
Nunes
Reinaldo Cavalcante
RC
Serviço de Endocrinologia, Hospital Universitário Clementino Fraga Filho (HUCFF), Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brasil.
Almeida
Mirella Hansen de
MH
Rodacki
Melanie
M
Noé
Rosângela Aparecida
RA
Bencke
Maria Rocio
MR
Oliveira
José Egídio Paulo de
JE
Vaisman
Mario
M
D000224:Addison Disease / Q000201:enzymology / Q000276:immunology; D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000201:enzymology* / Q000276:immunology; D005260:Female; D006801:Humans; D007453:Iodide Peroxidase / Q000276:immunology*; D008297:Male; D018709:Statistics, Nonparametric; D013255:Steroid 21-Hydroxylase / Q000276:immunology*; D013967:Thyroiditis, Autoimmune / Q000201:enzymology / Q000276:immunology; D013972:Thyrotropin / Q000097:blood
D001323:Autoantibodies; D015415:Biomarkers; D013972:Thyrotropin; D007453:Iodide Peroxidase; D013255:Steroid 21-Hydroxylase