Association between insulin resistance and carotid arterial stiffness in nondiabetic hemodialysis patients.
BACKGROUND
Patients with end-stage renal disease are known to have insulin resistance and advanced arterial stiffness. The present study was undertaken to investigate whether insulin resistance was correlated with carotid arterial stiffness in hemodialysis patients.


METHODS
Eighty nondiabetic hemodialysis patients were recruited. Stiffness index beta of the common carotid artery was assessed by ultrasound using echo-tracking system. Insulin resistance was evaluated by the homeostasis model assessment method (HOMA-IR). Serum albumin, lipid profile, calcium, phosphorus, intact parathyroid hormone, high-sensitivity C-reactive protein and oxidized low-density lipoprotein (ox-LDL) were also measured.


RESULTS
Patients with higher HOMA-IR levels had higher BMI, ox-LDL, and stiffness index beta than patients with lower HOMA-IR levels. HOMA-IR was independently correlated with stiffness index beta (beta = 0.260, p = 0.016). BMI and ox-LDL were independent contributors to HOMA-IR.


CONCLUSIONS
Insulin resistance assessed by HOMA-IR is closely associated with carotid arterial stiffness in nondiabetic hemodialysis patients.
Zhou
Yilun
Y
Department of Nephrology, ChaoYang Hospital, Capital Medical University, Beijing, China.
Yu
Zexing
Z
Jia
Huimin
H
Sun
Fang
F
Ma
Lijie
L
Guo
Ruijun
R
Peng
Liren
L
Cui
Taigen
T
D000368:Aged; D015992:Body Mass Index; D002339:Carotid Arteries / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D014463:Ultrasonography
D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein