[Structural and functional organization of the cerebral dopaminergic system].
The structural and functional organization of the cerebral dopaminergic system is considered. The synthesis of dopamine, distribution of dopaminergic structures, structure and classification of dopamin receptors in the brain, and functions of dopamine are discussed. Dopamin among the main catecholamine neurotransmitters participating in the control of locomotor activity, cognition, emotion, positive reinforcement, food intake, and endocrine regulation. Moreover, several neurological diseases such as Parkinson's disease, schizophrenia, and hyperprolactinemia are associated with dysregulation of dopaminergic neurotransmission. Therefore, the search for and development of new dopaminergic drugs is of great interest.
Barishpolets
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Fedotova
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IuO
Sapronov
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D000818:Animals; D001921:Brain / Q000502:physiology*; D002395:Catecholamines / Q000378:metabolism; D004298:Dopamine / Q000502:physiology*; D006801:Humans; D009419:Nerve Tissue Proteins / Q000502:physiology; D018377:Neurotransmitter Agents / Q000502:physiology; D017447:Receptors, Dopamine D1 / Q000502:physiology; D017448:Receptors, Dopamine D2 / Q000502:physiology; D009435:Synaptic Transmission / Q000502:physiology*
D002395:Catecholamines; D009419:Nerve Tissue Proteins; D018377:Neurotransmitter Agents; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D004298:Dopamine