title: Transformation of neuronal modes associated with low-Mg2+/high-K+ conditions in an in vitro model of epilepsy.
abstract: Nonparametric system modeling constitutes a robust method for the analysis of physiological systems as it can be used to identify nonlinear dynamic input-output relationships and facilitate their description. First- and second-order kernels of hippocampal CA3 pyramidal neurons in an in vitro slice preparation were computed using the Volterra-Wiener approach to investigate system changes associated with epileptogenic low-magnesium/high-potassium (low-Mg(2+)/high-K(+)) conditions. The principal dynamic modes (PDMs) of neurons were calculated from the first- and second-order kernel estimates in order to characterize changes in neural coding functionality. From our analysis, an increase in nonlinear properties was observed in kernels under low-Mg(2+)/high-K(+). Furthermore, the PDMs revealed that the sampled hippocampal CA3 neurons were primarily of integrating character and that the contribution of a differentiating mode component was enhanced under low-Mg(2+)/high-K(+).
authors: Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, M5S 3G9, Canada.
authors: Eunji E
authors: EE
authors: Kang
authors: Osbert C
authors: OC
authors: Zalay
authors: Marija
authors: M
authors: Cotic
authors: Peter L
authors: PL
authors: Carlen
authors: Berj L
authors: BL
authors: Bardakjian