Palladium-catalysed enantioselective alpha-hydroxylation of beta-ketoesters.
Highly enantioselective alpha-hydroxylation of cyclic and acyclic 1,3-ketoesters can be achieved with up to 98% ee using a dicationic palladium(ii) catalyst and dimethyldioxirane as oxidant.
Smith
Alexander M R
AM
Department of Chemistry, Imperial College London, South Kensington, London, UK.
Billen
Denis
D
Hii
King Kuok Mimi
KK
D002384:Catalysis; D004952:Esters / Q000138:chemical synthesis / Q000737:chemistry*; D006900:Hydroxylation; D007659:Ketones / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism
D004952:Esters; D007659:Ketones; D010165:Palladium