title: Hemodynamic effects of the early and long-term administration of propranolol in rats with intrahepatic portal hypertension.
abstract: Background and aims The aims of this study were to evaluate a preventive effect on collateral venous circulation of long-term administration of propranolol in intrahepatic portal hypertensive rats. Methods Eighty-six Sprague-Dawley rats were allocated to two models of hepatic fibrosis, bile duct-ligated (BDL) induced and carbon tetrachloride (CCl(4)) induced. Each model was divided into two groups: one receiving placebo and the other propranolol (75 mg kg(-1) d(-1)). Mean arterial pressure (MAP), heart rate (HR), portal pressure (PP), cardiac index (CI), vascular systemic resistance, and splenorenal shunt blood flow (SRS-BF) were measured in anesthetized rats. Results In the BDL model, no significant hemodynamic changes were observed in the propranolol group compared with the placebo group. In CCl(4)-induced rats, HR (390 +/- 50 vs. 329 +/- 51 beats/min, P = .001), CI (44 +/- 11 vs. 34 +/- 10 ml/min, P = .004), PP (15.4 +/- 3.0 vs. 13.4 +/- 1.9 mmHg, P = .045), and SRS-BF (1.4 +/- 1.1 vs. 1.0 +/- 1.0 ml/min, P = .047) were significantly lower in the propranolol group. Conclusions This study showed that propranolol has a significant hemodynamic effect only in the CCl(4) model and suggested a model-dependent effect of propranolol.
authors: Laboratoire HIFIH, UPRES EA 3859, UFR de Médecine, Université d'Angers, Angers, France.
authors: Lionel
authors: L
authors: Fizanne
authors: Nicolas
authors: N
authors: Régenet
authors: Jianhua
authors: J
authors: Wang
authors: Frédéric
authors: F
authors: Oberti
authors: Frédéric
authors: F
authors: Moal
authors: Jerôme
authors: J
authors: Roux
authors: Yves
authors: Y
authors: Gallois
authors: Sophie
authors: S
authors: Michalak
authors: Paul
authors: P
authors: Calès