Isoflavonoids from Flemingia strobilifera (L) R. Br. roots.
A new isoflavone (1) isolated from the roots of Flemingia strobilifera (L) R. Br. was identified as 5,7,4'-trihydroxy 8,2',5'-tri(3-methylbut-2-enyl)isoflavone along with the known phytoconstituents: 5,7,2',4'-tetrahydroxyisoflavone (2), 5,7,4'-trihydroxyisoflavone (3) and beta-sitosterol (4). Structure assignments were performed on the basis of spectroscopic data including homo- and heteronuclear 1D and 2D NMR (COSY, HMBC and DEPT) and MS studies. The compounds were tested in vitro for antimicrobial activity and antioxidant activity and compounds (1-3) proved to be moderately active.
Madan
Swati
S
Central Indian Pharmacopoeia Laboratory, Ministry of Health and Family Welfare, Sector-23, Raj Nagar, Ghaziabad, U.P.-201002, India.
Singh
Gyanendra Nath
GN
Kohli
Kanchan
K
Ali
Mohammed
M
Kumar
Yatendra
Y
Singh
Raman Mohan
RM
Prakash
Om
O
D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology; D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology; D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology; D007887:Fabaceae / Q000737:chemistry*; D007529:Isoflavones / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008826:Microbial Sensitivity Tests; D018517:Plant Roots
C543003:5,7,4'-trihydroxy 8,2',5'-tri(3-methylbut-2-enyl)isoflavone; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000975:Antioxidants; D007529:Isoflavones