title: A novel mouse model for the aggressive variant of NK cell and T cell large granular lymphocyte leukemia.
abstract: Murine models of disease are vital to the understanding of pathogenesis and the development of novel therapeutics. We have previously established interleukin (IL)-15 transgenic (tg) mice that demonstrate rapid proliferation of natural killer (NK) and T cells, followed by spontaneous transformation to lethal leukemia. Herein, we have characterized this model, which has many features in common with the aggressive variants of NK and T large granular lymphocyte leukemia (LGLL) in humans. The LGLL blasts are cytolytic and produce IFN-gammaex vivo. Cytogenetic analysis revealed trisomy of chromosome 17 and/or 15. This model should provide opportunities to develop effective standard therapies for this fatal disease.
authors: Department of Molecular Virology, Immunology, and Medical Genetics, Department of Internal Medicine, Division of Hematology/Oncology, The Ohio State University College of Medicine, Columbus, OH, United States.
authors: Akihiko
authors: A
authors: Yokohama
authors: Anjali
authors: A
authors: Mishra
authors: Takeki
authors: T
authors: Mitsui
authors: Brian
authors: B
authors: Becknell
authors: Jessica
authors: J
authors: Johns
authors: Douglas
authors: D
authors: Curphey
authors: Bradley W
authors: BW
authors: Blaser
authors: Jeffrey B
authors: JB
authors: Vandeusen
authors: Hsiaoyin
authors: H
authors: Mao
authors: Jianhua
authors: J
authors: Yu
authors: Michael A
authors: MA
authors: Caligiuri
mesh_terms: D000818:Animals; D001752:Blast Crisis; D049109:Cell Proliferation; D033481:Chromosomes, Mammalian; D004195:Disease Models, Animal; D007371:Interferon-gamma / Q000096:biosynthesis; D019409:Interleukin-15 / Q000235:genetics; D007694:Killer Cells, Natural / Q000473:pathology; D054066:Leukemia, Large Granular Lymphocytic / Q000235:genetics / Q000473:pathology*; D051379:Mice; D008822:Mice, Transgenic; D010641:Phenotype; D013601:T-Lymphocytes / Q000473:pathology; D014314:Trisomy
chemical_list: D019409:Interleukin-15; D007371:Interferon-gamma