Protective effects of Salvia miltiorrhizae on multiple organs of rats with obstructive jaundice.
OBJECTIVE
we aim to explore the protective effects of Salvia miltiorrhizae injection on multiple organs of obstructive jaundice (OJ) rats through observing the impact of this injection on the pathological alterations in these organs and the contents of endotoxin, PLA(2), and TNF-alpha in the blood.


METHODS
A total of 90 mice were randomly divided into sham-operated group, model-control group, and Salvia miltiorrhizae-treated group (n = 30). According to the duration of postoperative administration, each group was further divided into two subgroups, namely, 21 d subgroup (consecutive administration for 21 d, n = 15) and 28 d subgroup (consecutive administration for 28 d, n = 15). After administration, the pathological alterations in multiple organs were observed and the contents of endotoxin, PLA(2), and TNF-alpha in the blood were determined.


RESULTS
Compared to model control group, the number of dead rats in treated group decreased though there was no statistical difference between the two groups. The pathological alterations in the liver, kidney, and spleen in treated group showed varying degrees of mitigation. At all time points, the contents of plasma endotoxin declined significantly. On day 28, plasma PLA(2) content in treated group was significantly lower than that in model-control group.


CONCLUSIONS
Salvia miltiorrhizae injection is able to obviously reduce the contents of inflammatory mediators in the blood of OJ rats and exert some protective effects on multiple organs of these rats.
Ling
Zhang
Z
The Cardiovascular Research Laboratory, Lakehead University, 290 Munro Street, Thunder Bay, ON, Canada P7A 7 T1.
Xiping
Zhang
Z
Fengmei
Qiu
Q
Ping
Yan
Y
Qihui
Cheng
C
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D004731:Endotoxins / Q000097:blood; D007413:Intestinal Mucosa / Q000187:drug effects / Q000473:pathology; D041781:Jaundice, Obstructive / Q000097:blood / Q000188:drug therapy / Q000473:pathology*; D007684:Kidney Tubules / Q000187:drug effects / Q000473:pathology; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008297:Male; D008853:Microscopy; D054467:Phospholipases A2 / Q000097:blood; D011650:Pulmonary Alveoli / Q000187:drug effects / Q000473:pathology; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D027561:Salvia miltiorrhiza / Q000737:chemistry*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
D004365:Drugs, Chinese Herbal; D004731:Endotoxins; D014409:Tumor Necrosis Factor-alpha; D054467:Phospholipases A2