MicroRNAs cross the line: the battle for mRNA stability enters the coding sequence.
A study in this issue of Molecular Cell (Elcheva et al., 2009) shows the inherent instability of the betaTrCP1 mRNA to be caused by microRNA-183 targeting the coding sequence; interestingly, this action is directly opposed by the RNA-binding protein CRD-BP.
Nielsen
Anne F
AF
Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr. Bohr-Gasse 3, 1030 Vienna, Austria.
Gloggnitzer
Jiradet
J
Martinez
Javier
J
D060565:Argonaute Proteins; D001665:Binding Sites; D015852:Eukaryotic Initiation Factor-2 / Q000378:metabolism; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism / Q000502:physiology*; D008957:Models, Genetic; D020871:RNA Stability / Q000502:physiology*; D012333:RNA, Messenger / Q000737:chemistry / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000502:physiology; D044844:beta-Transducin Repeat-Containing Proteins / Q000235:genetics / Q000378:metabolism
C466422:AGO2 protein, human; D060565:Argonaute Proteins; C471644:BTRC protein, human; D015852:Eukaryotic Initiation Factor-2; C406144:IGF2BP1 protein, human; C533449:MIRN183 microRNA, human; D035683:MicroRNAs; D012333:RNA, Messenger; D016601:RNA-Binding Proteins; D044844:beta-Transducin Repeat-Containing Proteins