Smooth(ing) muscle differentiation by microRNAs.
In a recent report in Nature, Cordes et al. (2009) demonstrate that miR-143 and miR-145 modulate smooth muscle cell (SMC) plasticity in part by regulating key transcription factors involved in SMC fate determination.
Neppl
Ronald L
RL
Department of Cardiology, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA.
Wang
Da-Zhi
DZ
D000818:Animals; D002454:Cell Differentiation; D034481:Heterogeneous-Nuclear Ribonucleoprotein Group A-B / Q000378:metabolism*; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D032389:Myocytes, Smooth Muscle / Q000166:cytology / Q000378:metabolism*; D009687:Nuclear Proteins / Q000378:metabolism*; D012097:Repressor Proteins / Q000378:metabolism*; D026362:Serum Response Factor / Q000378:metabolism*; D015534:Trans-Activators / Q000378:metabolism*; D000099251:Myocardin
D034481:Heterogeneous-Nuclear Ribonucleoprotein Group A-B; D035683:MicroRNAs; D009687:Nuclear Proteins; D012097:Repressor Proteins; D026362:Serum Response Factor; D015534:Trans-Activators; D000099251:Myocardin; C077048:Hnrnpab protein, mouse