title: Synthesis, functionalization and photo-Bergman chemistry of enediyne bioconjugates.
abstract: Methodology is outlined for the chemical synthesis of versatile photo-Bergman enediyne building blocks and their conjugates. Routes to both mono and bis conjugated enediyne templates are detailed together with representative examples of their bioconjugates, nanoconjugates, PEG derivatives and water soluble salts. The immunocompetence of antibody conjugates is retained, and application in the form of reagents for photodynamic therapy (PDT) advanced.
authors: Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115, United States.
authors: Paul
authors: P
authors: LaBeaume
authors: Krista
authors: K
authors: Wager
authors: Danielle
authors: D
authors: Falcone
authors: Jane
authors: J
authors: Li
authors: Vladimir
authors: V
authors: Torchilin
authors: Curtis
authors: C
authors: Castro
authors: Coleen
authors: C
authors: Holewa
authors: Amy E
authors: AE
authors: Kallmerten
authors: Graham B
authors: GB
authors: Jones
mesh_terms: D000906:Antibodies / Q000737:chemistry / Q000276:immunology; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D053281:Enediynes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006046:Gold / Q000737:chemistry; D053768:Metal Nanoparticles / Q000737:chemistry; D017319:Photosensitizing Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011092:Polyethylene Glycols / Q000737:chemistry
chemical_list: D000906:Antibodies; D000970:Antineoplastic Agents; D053281:Enediynes; D017319:Photosensitizing Agents; D011092:Polyethylene Glycols; D006046:Gold