title: Long-term results of breast conservation in Chinese women with breast cancer.
abstract: Between July 1989 and December 2002, 172 women with Stage I/II breast cancer were treated by breast conservation therapy (BCT). All underwent quadrantectomy and axillary node clearance. Minimum follow-up was 5 years and 79 (52%) were followed for >10 years. At 5 years, local relapse-free and overall survival rates were 98.3% and 98.3%. The 10-year rates were 95% and 94%, respectively. The 10-year local recurrence rate was higher in patients with involved margins (33.3% versus 2.7%, p = 0.0272). Furthermore 10-year death rates in margin positive patients were higher (18.2% versus 2.5%, p = 0.0486). Excellent or good cosmetic results were achieved in 54%. BCT is a reasonable option for early stage breast cancer in Chinese women but margin status is the most important determinant of local recurrence. Negative margins are required for optimal local control and minimization of distant metastasis.
authors: Tianjin Medical University Cancer Hospital & Institute, Tianjin, China.
authors: Jun
authors: J
authors: Liu
authors: Juin
authors: J
authors: Liu
authors: Xi-Shan
authors: XS
authors: Hao
authors: Yong
authors: Y
authors: Yu
authors: Zhi-Yi
authors: ZY
authors: Fang
authors: Jun-Tian
authors: JT
authors: Liu
authors: Yun
authors: Y
authors: Niu
authors: Ian S
authors: IS
authors: Fentiman
mesh_terms: D000328:Adult; D000368:Aged; D001365:Axilla; D001943:Breast Neoplasms / Q000453:epidemiology* / Q000473:pathology / Q000601:surgery*; D002681:China / Q000453:epidemiology; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000601:surgery; D015412:Mastectomy, Segmental / Q000379:methods / Q000706:statistics & numerical data*; D008875:Middle Aged; D009367:Neoplasm Staging; D017060:Patient Satisfaction / Q000706:statistics & numerical data*; D012008:Recurrence; D016896:Treatment Outcome; D016387:Women's Health