title: Rounded atelectasis and respiratory compromise secondary to pergolide use.
abstract: Rounded atelectasis is an unusual form of peripheral atelectasis that develops as a consequence of pleural disease. It is usually thought to be a benign process after malignancy and infection have been excluded. Pergolide is an ergot-derived dopamine agonist that has been associated with pleuropulmonary fibrosis and fibrotic cardiac valve disease. Pergolide-associated rounded atelectasis has occurred in patients with known asbestos exposure. We report a patient with no known asbestos exposure who developed rounded atelectasis and subsequent symptomatic diffuse restrictive pleural disease. Physicians should consider drugs early on in their work-up of rounded atelectasis as discontinuation of the agent may reverse the process.
authors: Hillingdon Hospital, Pield Heath, Uxbridge, UK. chloebloom@doctors.org.uk
authors: Chloe I
authors: CI
authors: Bloom
authors: Graeme E
authors: GE
authors: Wilson
mesh_terms: D000368:Aged; D000978:Antiparkinson Agents / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D010300:Parkinson Disease / Q000188:drug therapy; D010479:Pergolide / Q000009:adverse effects* / Q000627:therapeutic use; D010995:Pleural Diseases / Q000139:chemically induced* / Q000175:diagnosis; D001261:Pulmonary Atelectasis / Q000139:chemically induced* / Q000175:diagnosis
chemical_list: D000978:Antiparkinson Agents; D010479:Pergolide