title: Asthma and posttraumatic stress symptoms 5 to 6 years following exposure to the World Trade Center terrorist attack.
abstract: BACKGROUND
  The World Trade Center Health Registry provides a unique opportunity to examine long-term health effects of a large-scale disaster.
  
  
  OBJECTIVE
  To examine risk factors for new asthma diagnoses and event-related posttraumatic stress (PTS) symptoms among exposed adults 5 to 6 years following exposure to the September 11, 2001, World Trade Center (WTC) terrorist attack.
  
  
  METHODS
  Longitudinal cohort study with wave 1 (W1) enrollment of 71,437 adults in 2003-2004, including rescue/recovery worker, lower Manhattan resident, lower Manhattan office worker, and passersby eligibility groups; 46,322 adults (68%) completed the wave 2 (W2) survey in 2006-2007.
  
  
  METHODS
  Self-reported diagnosed asthma following September 11; event-related current PTS symptoms indicative of probable posttraumatic stress disorder (PTSD), assessed using the PTSD Checklist (cutoff score > or = 44).
  
  
  RESULTS
  Of W2 participants with no stated asthma history, 10.2% (95% confidence interval [CI], 9.9%-10.5%) reported new asthma diagnoses postevent. Intense dust cloud exposure on September 11 was a major contributor to new asthma diagnoses for all eligibility groups: for example, 19.1% vs 9.6% in those without exposure among rescue/recovery workers (adjusted odds ratio, 1.5 [95% CI, 1.4-1.7]). Asthma risk was highest among rescue/recovery workers on the WTC pile on September 11 (20.5% [95% CI, 19.0%-22.0%]). Persistent risks included working longer at the WTC site, not evacuating homes, and experiencing a heavy layer of dust in home or office. Of participants with no PTSD history, 23.8% (95% CI, 23.4%-24.2%) reported PTS symptoms at either W1 (14.3%) or W2 (19.1%). Nearly 10% (9.6% [95% CI, 9.3%-9.8%]) had PTS symptoms at both surveys, 4.7% (95% CI, 4.5%-4.9%) had PTS symptoms at W1 only, and 9.5% (95% CI, 9.3%-9.8%) had PTS symptoms at W2 only. At W2, passersby had the highest rate of PTS symptoms (23.2% [95% CI, 21.4%-25.0%]). Event-related loss of spouse or job was associated with PTS symptoms at W2.
  
  
  CONCLUSIONS
  Acute and prolonged exposures were both associated with a large burden of asthma and PTS symptoms 5 to 6 years after the September 11 WTC attack.
authors: Agency for Toxic Substances and Disease Registry, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
authors: Robert M
authors: RM
authors: Brackbill
authors: James L
authors: JL
authors: Hadler
authors: Laura
authors: L
authors: DiGrande
authors: Christine C
authors: CC
authors: Ekenga
authors: Mark R
authors: MR
authors: Farfel
authors: Stephen
authors: S
authors: Friedman
authors: Sharon E
authors: SE
authors: Perlman
authors: Steven D
authors: SD
authors: Stellman
authors: Deborah J
authors: DJ
authors: Walker
authors: David
authors: D
authors: Wu
authors: Shengchao
authors: S
authors: Yu
authors: Lorna E
authors: LE
authors: Thorpe
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000393:Air Pollutants; D001249:Asthma / Q000453:epidemiology*; D004391:Dust; D005260:Female; D006296:Health Services / Q000706:statistics & numerical data; D006306:Health Surveys; D006801:Humans; D019570:Inhalation Exposure; D008016:Life Change Events; D016015:Logistic Models; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009519:New York City / Q000453:epidemiology; D011788:Quality of Life; D012042:Registries; D012307:Risk Factors; D047851:September 11 Terrorist Attacks; D012720:Severity of Illness Index; D013313:Stress Disorders, Post-Traumatic / Q000453:epidemiology*; D055815:Young Adult
chemical_list: D000393:Air Pollutants; D004391:Dust