Churg-Strauss syndrome associated with montelukast therapy.
Churg-Strauss syndrome is a rare form of eosinophilic vasculitis associated with asthma. Several cases of eosinophilic conditions including Churg-Strauss syndrome have recently been reported in asthmatic patients being treated with antileukotriene receptor antagonists. However, whether these drugs have a direct pathogenic role remains controversial. We describe two patients who developed Churg-Strauss syndrome after starting treatment with montelukast.
Kaliterna
Dusanka Martinović
DM
Department of Internal Medicine, University Hospital Split, Split, Croatia.
Perković
Dijana
D
Radić
Mislav
M
D000085:Acetates / Q000009:adverse effects*; D000328:Adult; D000369:Aged, 80 and over; D018927:Anti-Asthmatic Agents / Q000009:adverse effects*; D001249:Asthma / Q000188:drug therapy*; D015267:Churg-Strauss Syndrome / Q000139:chemically induced*; D003521:Cyclopropanes; D005260:Female; D006801:Humans; D020024:Leukotriene Antagonists / Q000009:adverse effects*; D008297:Male; D011657:Pulmonary Eosinophilia / Q000139:chemically induced; D011804:Quinolines / Q000009:adverse effects*; D013440:Sulfides
D000085:Acetates; D018927:Anti-Asthmatic Agents; D003521:Cyclopropanes; D020024:Leukotriene Antagonists; D011804:Quinolines; D013440:Sulfides; C093875:montelukast