title: [Clinical observation of heparin-induced thrombocytopenia].
abstract: OBJECTIVE
  To explore the treatment of heparin-induced thrombocytopenia (HIT) in venous thromboembolism.
  
  
  METHODS
  A total of 202 patients with venous thromboembolism without anticoagulation contraindications were enrolled. All of them were treated with low molecular weight heparin (LMWH) and/or unfractionated heparin (UFH). The peripheral blood cells were examined regularly.
  
  
  RESULTS
  HIT occurred in 6 patients. And argatroban was used to treat HIT. The overall incidence rate of HIT in this study was 2.97%. The time of occurrence of HIT was about Days 3 - 9 after using heparin. The platelet recovered to the basic level at Days 3 - 7 after withdrawing heparin and initiating argatroban.
  
  
  CONCLUSIONS
  The count of platelet should be measured in the patients receiving regular LMWH and/or UFH therapy. And the above regimen should be discontinued timely when the platelet count declined progressively by over 50%. Argatroban was effective.
authors: Department of Cardiology and Peripheral Vascular Diseases, First Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an, 710061, China. tianhhyy@mail.xjtu.edu.cn
authors: Hong-yan
authors: HY
authors: Tian
authors: Yan
authors: Y
authors: Meng
authors: Jun-bo
authors: JB
authors: Zhang
authors: Qiang
authors: Q
authors: Ma
authors: Ge-sheng
authors: GS
authors: Cheng
authors: Fen-ling
authors: FL
authors: Fan
authors: Jun
authors: J
authors: Wang
authors: Hong-mei
authors: HM
authors: Wan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000009:adverse effects* / Q000627:therapeutic use; D001120:Arginine / Q000031:analogs & derivatives; D005260:Female; D006493:Heparin / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D010875:Pipecolic Acids / Q000627:therapeutic use; D010976:Platelet Count; D013449:Sulfonamides; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000188:drug therapy; D054556:Venous Thromboembolism / Q000188:drug therapy; D055815:Young Adult
chemical_list: D000925:Anticoagulants; D010875:Pipecolic Acids; D013449:Sulfonamides; D006493:Heparin; D001120:Arginine; C031942:argatroban