Electrospun materials as potential platforms for bone tissue engineering.
Nanofibrous materials produced by electrospinning processes have attracted considerable interest in tissue regeneration, including bone reconstruction. A range of novel materials and processing tools have been developed to mimic the native bone extracellular matrix for potential applications as tissue engineering scaffolds and ultimately to restore degenerated functions of the bone. Degradable polymers, bioactive inorganics and their nanocomposites/hybrids nanofibers with suitable mechanical properties and bone bioactivity for osteoblasts and progenitor/stem cells have been produced. The surface functionalization with apatite minerals and proteins/peptides as well as drug encapsulation within the nanofibers is a promising strategy for achieving therapeutic functions with nanofibrous materials. Recent attempts to endow a 3D scaffolding technique to the electrospinning regime have shown some promise for engineering 3D tissue constructs. With the improvement in knowledge and techniques of bone-targeted nanofibrous matrices, bone tissue engineering is expected to be realized in the near future.
Jang
Jun-Hyeog
JH
Department of Biochemistry, Inha University College of Medicine, South Korea.
Castano
Oscar
O
Kim
Hae-Won
HW
D000818:Animals; D018786:Bone Substitutes / Q000737:chemistry*; D001842:Bone and Bones / Q000166:cytology / Q000378:metabolism; D004563:Electrochemistry; D016326:Extracellular Matrix Proteins / Q000378:metabolism; D006801:Humans; D057139:Nanofibers / Q000737:chemistry*; D010006:Osteoblasts / Q000166:cytology / Q000378:metabolism; D010010:Osteoclasts / Q000166:cytology / Q000378:metabolism; D010012:Osteogenesis / Q000502:physiology; D023822:Tissue Engineering / Q000379:methods*
D018786:Bone Substitutes; D016326:Extracellular Matrix Proteins