Multiple intravascular papillary endothelial hyperplasia affecting skin and bone.
We report a 75-year-old man with multiple recurrent black papules involving his entire body. In the course of 3 years, 20 lesions were resected, which were histologically confirmed as intravascular papillary endothelial hyperplasia (IPEH). A similar vascular lesion was found on his tibia. The occurrence of multiple IPEH affecting skin and bone is extremely rare. The patient's medical history included hepatitis C, hepatoma and associated coagulopathy. We suggest that this patient's multiple lesions were induced by microthrombus formation due to liver dysfunction.
Higashi
Y
Y
Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan. higashiy@m.kufm.kagoshima-u.ac.jp
Uchida
Y
Y
Yoshii
N
N
Kubo
H
H
Kanzaki
T
T
Yokouchi
M
M
Kanekura
T
T
D000368:Aged; D004730:Endothelium, Vascular / Q000473:pathology*; D006801:Humans; D006965:Hyperplasia / Q000473:pathology; D008297:Male; D012867:Skin / Q000098:blood supply / Q000473:pathology*; D013977:Tibia / Q000098:blood supply / Q000473:pathology*