title: One year outcome of manual alcohol-assisted removal of Salzmann's nodular degeneration.
abstract: BACKGROUND
  To analyze visual and refractive modifications and corneal topography changes in a patient treated for bilateral advanced Salzmann's nodular degeneration (SND).
  
  
  METHODS
  A forty-three-year-old man with bilateral advanced SND underwent manual, alcohol-assisted removal of the altered layer. Visual acuity, refraction, corneal topography and corneal aberrations were examined before and after the treatment after 7 days and 1, 6 and 12 months.
  
  
  RESULTS
  The uncorrected visual acuity changed from 0.1 to 1.0 in both eyes. Refraction changed from sphere +3.00 and cylinder +4.50 x 180 degrees in the right eye and sphere +6 and cylinder +4.0 x 170 degrees in the left eye to bilateral emetropia. Corneal topography recovered from an extremely flat profile to a normal shape and it was unvaried during the follow-up period. Main topographic indices, highly altered before the treatment, normalized and were normal at control examinations. The quality of vision improved significantly with reduction of high-order aberrations from RMS of 5,07 microm to 0,66 microm in the right eye and RMS of 4,89 microm to 0,57 microm in the left eye respectively.
  
  
  CONCLUSIONS
  Salzmann nodules produce an impressive central corneal flattening with high hyperopic refractive error and significant increment of corneal aberrations. After manual removal of the altered layer, the visual and refractive recovery, corneal topography and aberrometry normalization were immediate and stable during the observational period.
authors: Ophthalmology Unit, Department of Surgical Specialties, A.O.U. Messina, University of Messina, Viale Consolare Valeria, Messina, Italy. anrosz@tiscali.it
authors: Anna M
authors: AM
authors: Roszkowska
authors: Pietro
authors: P
authors: Colosi
authors: Letteria
authors: L
authors: De Grazia
authors: Eliana
authors: E
authors: Mirabelli
authors: Giovanni
authors: G
authors: Romeo
mesh_terms: D000287:Administration, Topical; D000328:Adult; D003316:Corneal Diseases / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology / Q000601:surgery*; D019781:Corneal Topography; D000431:Ethanol / Q000008:administration & dosage*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D016896:Treatment Outcome; D014792:Visual Acuity
chemical_list: D000431:Ethanol