Dermatomyositis-like muscle pathology in patients with chronic graft-versus-host disease.
Myositis is a rare complication of chronic graft-versus-host disease (cGVHD) following hematopoietic stem cell transplantation (HSCT). Almost all such patients have been reported to have polymyositis (PM). We describe clinical, pathologic, and molecular studies of 3 patients with cGVHD following allogeneic HSCT who developed myopathy. In each case, perifascicular atrophy, the pathognomonic histologic feature of dermatomyositis (DM), was observed.
Allen
Jeffrey A
JA
Department of Neurology, Division of Neuromuscular Disease, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, Massachusetts 02115, USA. jallen1@nmff.org
Greenberg
Steven A
SA
Amato
Anthony A
AA
D000328:Adult; D002908:Chronic Disease; D003882:Dermatomyositis / Q000473:pathology* / Q000628:therapy; D004576:Electromyography; D005076:Exanthema / Q000473:pathology; D005260:Female; D006086:Graft vs Host Disease / Q000473:pathology* / Q000628:therapy; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007167:Immunotherapy; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications / Q000473:pathology / Q000628:therapy; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications / Q000473:pathology / Q000628:therapy; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000473:pathology / Q000628:therapy; D008297:Male; D018908:Muscle Weakness / Q000209:etiology; D018482:Muscle, Skeletal / Q000473:pathology*