[Peptides: a new class of anticancer drugs].
Peptides are a novel class of anticancer agents embracing two distinct categories: natural antibacterial peptides, which are preferentially bound by cancer cells, and chemically synthesized peptides, which bind specifically to precise molecular targets located on the surface of tumor cells. Antibacterial peptides bind to both cell and mitochondrial membranes. Some of these peptides attach to the cell membrane, resulting in its disorganization. Other antibacterial peptides penetrate cancer cells without causing cell membrane damage, but they disrupt mitochondrial membranes. Thanks to phage and aptamer libraries, it has become possible to obtain synthetic peptides blocking or activating some target proteins found in cancer cells as well as in cells forming the tumor environment. These synthetic peptides can feature anti-angiogenic properties, block enzymes indispensable for sustained tumor growth, and reduce tumor ability to metastasize. In this review the properties of peptides belonging to both categories are discussed and attempts of their application for therapeutic purposes are outlined.
Smolarczyk
Ryszard
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Zakład Biologii Molekularnej, Centrum Onkologii - Instytut im. Marii Skłodowskiej-Curie Oddział w Gliwicach. rsmolarczyk@io.gliwice.pl
Cichoń
Tomasz
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Szala
Stanisław
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D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D006801:Humans; D010455:Peptides / Q000494:pharmacology* / Q000627:therapeutic use*
D000970:Antineoplastic Agents; D010455:Peptides