Small molecule microarray-facilitated screening of affinity-based probes (AfBPs) for gamma-secretase.
A small molecule microarray (SMM) platform is developed herein, which enables high-throughput discovery of affinity-based probes (AfBPs) against gamma-secretase.
Shi
Haibin
H
Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543, Singapore.
Liu
Kai
K
Xu
Ashley
A
Yao
Shao Q
SQ
D053829:Amyloid Precursor Protein Secretases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D005456:Fluorescent Dyes / Q000737:chemistry; D046228:Microarray Analysis; D011480:Protease Inhibitors / Q000737:chemistry*; D011485:Protein Binding; D054852:Small Molecule Libraries; D013329:Structure-Activity Relationship
D005456:Fluorescent Dyes; D011480:Protease Inhibitors; D054852:Small Molecule Libraries; D053829:Amyloid Precursor Protein Secretases