Nanoscale analysis of supported lipid bilayers using atomic force microscopy.
During the past 15 years, atomic force microscopy (AFM) has opened new opportunities for imaging supported lipid bilayers (SLBs) on the nanoscale. AFM offers a means to visualize the nanoscale structure of SLBs in physiological conditions. A unique feature of AFM is its ability to monitor dynamic events, like bilayer alteration, remodelling or digestion, upon incubation with various external agents such as drugs, detergents, proteins, peptides, nanoparticles, and solvents. Here, we survey recent progress made in the area.
El Kirat
Karim
K
Laboratoire de Biomécanique et Bioingénierie, UMR-CNRS 6600, Université de Technologie de Compiègne, BP 20529, F-60205 Compiègne Cedex, France. kelkirat@utc.fr
Morandat
Sandrine
S
Dufrêne
Yves F
YF
D008051:Lipid Bilayers / Q000737:chemistry*; D008563:Membrane Lipids / Q000737:chemistry / Q000378:metabolism; D021962:Membrane Microdomains / Q000737:chemistry / Q000378:metabolism; D008565:Membrane Proteins / Q000737:chemistry / Q000378:metabolism; D018625:Microscopy, Atomic Force / Q000379:methods*; D008958:Models, Molecular; D049329:Nanostructures / Q000737:chemistry*; D036103:Nanotechnology; D011485:Protein Binding
D008051:Lipid Bilayers; D008563:Membrane Lipids; D008565:Membrane Proteins