Assessment of pro-vasopressin and pro-adrenomedullin as predictors of 28-day mortality in septic shock patients.
OBJECTIVE
Improvements in survival after septic shock will most likely rely on our capacity to manage individualized therapies based on the measurement of rapidly accessible biomarkers. As the early phase of septic shock is dominated by severe alterations of the cardiovascular system, the predictive value for mortality of pro-vasopressin (pro-AVP) and pro-adrenomedullin (pro-ADM), two vasoactive pro-hormones, was assessed.


METHODS
In 99 consecutive patients, pro-hormone concentrations were measured (immunoluminometric assay) three times within the first week after the onset of septic shock.


RESULTS
Pro-AVP and pro-ADM concentrations were significantly increased in non-survivors in comparison with survivors and were significantly associated with mortality after both univariate and multivariate analysis. Importantly, when assessed as a pair, pro-ADM and pro-AVP were even more informative.


CONCLUSIONS
Both Pro-ADM and pro-AVP appear to be good biomarkers for the prediction of 28-day mortality after septic shock. However, their association in a single variable tends to improve their predictive capacity.
Guignant
Caroline
C
Flow Cytometry Unit, Immunology Laboratory, Hôpital E. Herriot, Hospices Civils de Lyon, 5, Place d'Arsonval, 69437, Lyon cedex 03, France.
Voirin
Nicolas
N
Venet
Fabienne
F
Poitevin
Françoise
F
Malcus
Christophe
C
Bohé
Julien
J
Lepape
Alain
A
Monneret
Guillaume
G
D053607:Adrenomedullin / Q000097:blood*; D000368:Aged; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood*; D005260:Female; D005602:France / Q000453:epidemiology; D006020:Glycopeptides / Q000097:blood*; D006801:Humans; D007118:Immunoassay; D053208:Kaplan-Meier Estimate; D016015:Logistic Models; D008163:Luminescent Measurements; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D011498:Protein Precursors / Q000097:blood*; D012372:ROC Curve; D018570:Risk Assessment; D012720:Severity of Illness Index; D012772:Shock, Septic / Q000097:blood / Q000401:mortality; D018709:Statistics, Nonparametric
D015415:Biomarkers; D006020:Glycopeptides; D011498:Protein Precursors; C048197:copeptins; C088633:proadrenomedullin; D053607:Adrenomedullin