Flow NMR spectroscopy in drug discovery.
Flow NMR spectroscopy techniques are becoming increasingly utilized in drug discovery and development. LC-NMR has become a routine method to resolve and identify mixture components. It has broad applications in natural products biochemistry, and drug metabolism and toxicology studies. The rapid throughput of direct-injection NMR of biofluids, combinatorial chemistry samples and protein/small molecule mixtures positions NMR spectroscopy to impact metabonomics, medicinal chemistry and protein screening. The concomitant development of robust automated data analysis tools has facilitated interpretation of the vast amount of NMR data generated.
Stockman
B J
BJ
Structural, Analytical and Medicinal Chemistry, Pharmacia Corporation, Kalamazoo, MI 49001, USA. brian.j.stockman@am.pnu.com