[Anaphylaxis in terminal pregnancy: two case studies and review of the literature].
Anaphylaxis is a relative uncommon event in pregnancy that can have serious implications for both mother and foetus. Two cases of grade 3 anaphylactic shock occurring at the end of the third trimester of pregnancy are reported; the causal agents were respectively amoxicillin and suxamethonium. Maternal and foetal outcome was good after adequate resuscitation and caesarean section performed in both cases because of severe bradycardia. A review of the literature confirms the good maternal outcome; neurologic damage in the newborn is frequent. On the basis of physiologic findings degranulation of placental mast cell is evoked in the genesis of birth asphyxia.
Sleth
J-C
JC
Polyclinique St-Roch, 43, rue du faubourg St-Jaumes, 34967 Montpellier cedex 02, France. jean-christian.sleth@wanadoo.fr
Lafforgue
E
E
Cherici
O
O
Nagy
P
P
D000328:Adult; D000658:Amoxicillin / Q000009:adverse effects*; D000707:Anaphylaxis / Q000139:chemically induced* / Q000601:surgery; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D001919:Bradycardia / Q000209:etiology; D001925:Brain Damage, Chronic / Q000453:epidemiology / Q000209:etiology; D002585:Cesarean Section; D003218:Condylomata Acuminata / Q000601:surgery; D005260:Female; D005313:Fetal Death / Q000453:epidemiology / Q000209:etiology; D005315:Fetal Diseases / Q000209:etiology; D006801:Humans; D007231:Infant, Newborn; D007431:Intraoperative Complications / Q000139:chemically induced; D008407:Mast Cells / Q000378:metabolism; D009467:Neuromuscular Depolarizing Agents / Q000009:adverse effects*; D010920:Placenta / Q000276:immunology / Q000473:pathology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000139:chemically induced* / Q000188:drug therapy / Q000276:immunology / Q000601:surgery; D011256:Pregnancy Outcome; D011263:Pregnancy Trimester, Third; D013290:Streptococcal Infections / Q000188:drug therapy; D013390:Succinylcholine / Q000009:adverse effects*; D014845:Vulvar Diseases / Q000601:surgery
D000900:Anti-Bacterial Agents; D009467:Neuromuscular Depolarizing Agents; D000658:Amoxicillin; D013390:Succinylcholine