title: Comparative analysis of neurulation: first impressions do not count.
abstract: The central nervous system of vertebrate embryos originates from the neural tube (NT), a simple epithelium surrounding a central lumen. The mechanisms underlying the shaping of the NT, a process otherwise known as neurulation, have been the focus of numerous studies, using a variety of model systems. Yet, it remains unclear to what extent neurulation is conserved across vertebrates. This review provides a comparison between modes of neurulation, with a focus on cellular mechanisms. An emerging concept is that cell behaviors reveal similarities between modes of neurulation that cannot be predicted from morphological comparisons.
authors: Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, Maryland 21250, USA.
authors: Michael J
authors: MJ
authors: Harrington
authors: Elim
authors: E
authors: Hong
authors: Rachel
authors: R
authors: Brewster
mesh_terms: D000818:Animals; D054261:Neurulation / Q000502:physiology*; D015398:Signal Transduction