High biliary excretion levels of quercetin metabolites after administration of a quercetin glycoside in conscious bile duct cannulated rats.
Biliary excretion of quercetin metabolites in conscious rats was biphasic, a high peak within 3 h and a lower peak for next 6 h, after duodenal administration of soluble quercetin glycosides. We also found much higher biliary excretion of quercetin metabolites than urinary excretion on feeding a quercetin glycoside diet. These results suggest high levels of enterohepatic circulation of quercetin metabolites.
Matsukawa
Noriko
N
Laboratory of Nutritional Biochemistry, Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo, Hokkaido, Japan.
Matsumoto
Megumi
M
Hara
Hiroshi
H
D000818:Animals; D001646:Bile / Q000187:drug effects* / Q000378:metabolism*; D001652:Bile Ducts; D002404:Catheterization; D003243:Consciousness; D006027:Glycosides / Q000008:administration & dosage* / Q000494:pharmacology*; D008297:Male; D011794:Quercetin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000378:metabolism* / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley
D006027:Glycosides; D011794:Quercetin