Metal-ion-induced folding and dimerization of a glycoluril decamer in water.
In a process reminiscent of RNA folding, acyclic glycoluril decamer (+/-)-1 undergoes double helical assembly (red/green strands) in water triggered by the neutralization of regions of high electrostatic surface potential by metal cations (Li(+), Na(+), K(+), Ca(2+)).
Huang
Wei-Hao
WH
Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742, USA.
Zavalij
Peter Y
PY
Isaacs
Lyle
L
D000480:Alkynes / Q000737:chemistry* / Q000302:isolation & purification; D019281:Dimerization; D007093:Imidazoles / Q000737:chemistry* / Q000302:isolation & purification; D008670:Metals / Q000737:chemistry*; D008968:Molecular Conformation; D012313:RNA / Q000737:chemistry / Q000378:metabolism; D014867:Water / Q000737:chemistry*; D006574:Heterocyclic Compounds, 2-Ring; D048289:Imidazolidines
D000480:Alkynes; D007093:Imidazoles; D008670:Metals; D012313:RNA; D014867:Water; C092018:glycoluril; D006574:Heterocyclic Compounds, 2-Ring; D048289:Imidazolidines