title: Spontaneous closure of retinal pigment epithelium microrip in the natural course of central serous chorioretinopathy.
abstract: OBJECTIVE
  To study the natural course of changes observed in the retinal pigment epithelium (RPE) on spectral domain OCT transverse and RPE fit C-scans corresponding to the leakage point observed on fundus fluorescein angiograms in central serous chorioretinopathy (CSC).
  
  
  METHODS
  Thirteen patients with acute CSC were prospectively enrolled and followed up for 6 months. All were examined using Zeiss Cirrus HD-OCT Model 4000. Transverse and RPE fit C-scans corresponding to point of leakage were superimposed on an OCT fundus photograph and correlated with the leakage point on a fluorescein angiogram. The RPE alterations observed at the leakage point were noted at presentation and follow-up.
  
  
  RESULTS
  Transverse and RPE fit C-scans showed an irregularity of RPE resembling a 'honeycomb' pattern in 11 (85%) eyes at the point corresponding to the fluorescein leakage site. These were observed as pigment epithelium detachment (PED) on Raster line scan. Six of these 11 eyes (54.5%) showed a disruption/breach in the RPE on transverse C-scan and on RPE fit C-scan. All eyes showed a resolution of subretinal fluid with a closure of microrip, and the honeycombed pattern at the leakage site was replaced with RPE hypertrophy.
  
  
  CONCLUSIONS
  RPE microrips show spontaneous closure in the natural course of CSC.
authors: Advanced Eye Centre, Department of Ophthalmology, Post Graduate Institute of Medical Education and Research, Chandigarh, (UT), India. eyepgi@sify.com
authors: V
authors: V
authors: Gupta
authors: P
authors: P
authors: Gupta
authors: M R
authors: MR
authors: Dogra
authors: A
authors: A
authors: Gupta
mesh_terms: D000328:Adult; D056833:Central Serous Chorioretinopathy / Q000150:complications / Q000473:pathology*; D005260:Female; D005654:Fundus Oculi; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012075:Remission, Spontaneous; D012163:Retinal Detachment / Q000209:etiology / Q000473:pathology*; D055213:Retinal Pigment Epithelium / Q000473:pathology*; D041623:Tomography, Optical Coherence / Q000379:methods