title: Pre-hospital tracheal intubation in patients with traumatic brain injury: systematic review of current evidence.
abstract: BACKGROUND
  We reviewed the current evidence on the benefit and harm of pre-hospital tracheal intubation and mechanical ventilation after traumatic brain injury (TBI).
  
  
  METHODS
  We conducted a systematic literature search up to December 2007 without language restriction to identify interventional and observational studies comparing pre-hospital intubation with other airway management (e.g. bag-valve-mask or oxygen administration) in patients with TBI. Information on study design, population, interventions, and outcomes was abstracted by two investigators and cross-checked by two others. Seventeen studies were included with data for 15,335 patients collected from 1985 to 2004. There were 12 retrospective analyses of trauma registries or hospital databases, three cohort studies, one case-control study, and one controlled trial. Using Brain Trauma Foundation classification of evidence, there were 14 class 3 studies, three class 2 studies, and no class 1 study. Six studies were of adults, five of children, and three of both; age groups were unclear in three studies. Maximum follow-up was up to 6 months or hospital discharge.
  
  
  RESULTS
  In 13 studies, the unadjusted odds ratios (ORs) for an effect of pre-hospital intubation on in-hospital mortality ranged from 0.17 (favouring control interventions) to 2.43 (favouring pre-hospital intubation); adjusted ORs ranged from 0.24 to 1.42. Estimates for functional outcomes after TBI were equivocal. Three studies indicated higher risk of pneumonia associated with pre-hospital (when compared with in-hospital) intubation.
  
  
  CONCLUSIONS
  Overall, the available evidence did not support any benefit from pre-hospital intubation and mechanical ventilation after TBI. Additional arguments need to be taken into account, including medical and procedural aspects.
authors: German Cochrane Centre, Department of Medical Biometry and Statistics, University Medical Centre Freiburg, Stefan-Meier-Strasse 26, Freiburg D-79104, Germany. vonelm@cochrane.de
authors: E
authors: E
authors: von Elm
authors: P
authors: P
authors: Schoettker
authors: I
authors: I
authors: Henzi
authors: J
authors: J
authors: Osterwalder
authors: B
authors: B
authors: Walder
mesh_terms: D000293:Adolescent; D000328:Adult; D001930:Brain Injuries / Q000401:mortality / Q000628:therapy*; D002648:Child; D002675:Child, Preschool; D004632:Emergency Medical Services / Q000379:methods*; D019317:Evidence-Based Medicine / Q000379:methods; D017052:Hospital Mortality; D006801:Humans; D007223:Infant; D007442:Intubation, Intratracheal / Q000009:adverse effects; D012107:Research Design; D012121:Respiration, Artificial; D016896:Treatment Outcome; D055815:Young Adult