title: Cytologic, histologic, and immunohistochemical features of maxillofacial alveolar rhabdomyosarcoma in a juvenile dog.
abstract: A 15-month-old castrated male dog with a history of intermittent epistaxis and sneezing was admitted for the examination of a maxillofacial mass. An impression smear of a biopsy sample from the cauliflower-shaped gingival mass contained numerous round cells, 5-25 microm in diameter, which contained a moderate amount of clear to pale blue cytoplasm and resembled lymphoid cells. Mitotic figures were frequently observed. The mass was diagnosed as malignant round cell neoplasia. On histologic examination the tumor was composed of diffusely arranged, small, atypical round cells with a small amount of fibrovascular stroma. Immunohistochemically, the cells were negative for CD3, CD18, CD20, CD79alpha, cytokeratin, melan-A, chromogranin A, alpha-smooth muscle actin, and myoglobin but positive for vimentin and desmin. The cells also had strong positive nuclear staining for myogenin and MyoD1. A diagnosis of solid-pattern alveolar rhabdomyosarcoma was made on the basis of morphologic and immunohistochemical results. Alveolar rhabdomyosarcoma should be considered in the differential diagnosis of tumors in juvenile dogs, especially when cytologic findings reveal round, undifferentiated cells.
authors: Laboratories of Veterinary Pathology, Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan.
authors: Mami
authors: M
authors: Murakami
authors: Hiroki
authors: H
authors: Sakai
authors: Nao
authors: N
authors: Iwatani
authors: Aki
authors: A
authors: Asakura
authors: Yuki
authors: Y
authors: Hoshino
authors: Takashi
authors: T
authors: Mori
authors: Tokuma
authors: T
authors: Yanai
authors: Kohji
authors: K
authors: Maruo
authors: Toshiaki
authors: T
authors: Masegi
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000556:secondary / Q000662:veterinary; D004283:Dog Diseases / Q000175:diagnosis*; D004285:Dogs; D005153:Facial Neoplasms / Q000473:pathology / Q000662:veterinary*; D017809:Fatal Outcome; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000556:secondary / Q000662:veterinary; D008297:Male; D018232:Rhabdomyosarcoma, Alveolar / Q000473:pathology / Q000662:veterinary*