title: Dielectrophoretic technique for measurement of chemical and biological interactions.
abstract: We present a novel dielectrophoretic technique that can be used to characterize molecular interactions inside a microfluidic device. Our approach allows functionalized beads which are initially at rest on a functionalized surface to be pulled away from the surface by the dielectrophoretic force acting on the beads. As a result, the interaction between the molecules on the surface and the beads can be quantitatively examined. We report detailed experimental results and validate the results with a model to show that the technique can be used to measure forces of interaction between molecules under various experimental conditions.
authors: Department of Biomedical Engineering, Yonsei University, Wonju 220-710, Korea.
authors: Sang Hyun
authors: SH
authors: Baek
authors: Woo-Jin
authors: WJ
authors: Chang
authors: Ju-Yeoul
authors: JY
authors: Baek
authors: Dae Sung
authors: DS
authors: Yoon
authors: Rashid
authors: R
authors: Bashir
authors: Sang Woo
authors: SW
authors: Lee
mesh_terms: D004563:Electrochemistry / Q000379:methods*; D004586:Electrophoresis / Q000379:methods*; D046209:Electrophoresis, Microchip / Q000295:instrumentation* / Q000379:methods; D008239:Lysine / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry; D013387:Succinic Anhydrides / Q000737:chemistry; D013499:Surface Properties
chemical_list: D013387:Succinic Anhydrides; C031801:succinic anhydride; D012822:Silicon Dioxide; D008239:Lysine