Synthesis of Neu5Ac-Gal-functionalized gold glyconanoparticles.
Neu5Ac-Gal-containing neoglycoside 1 was convergently synthesized through Cu(I)-catalyzed 1,3-dipolar cycloaddition of methyl (6-azidohexyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-2-O-alpha-d-glycero-d-galacto-2-nonulopyranosyl)uronate and 11-thioacetylundecyl 2,4,6-tri-O-benzoyl-3-O-propargyl-beta-d-galactopyranoside. The stable and water-soluble gold glyconanoparticle 2 (d=3.4nm) has been successfully prepared from neoglycoside 1 and characterized by NMR, IR, and TEM techniques.
Zhang
Lei
L
Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
Wei
Guohua
G
Du
Yuguo
Y
D006001:Glycoconjugates / Q000138:chemical synthesis* / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D015394:Molecular Structure; D019158:N-Acetylneuraminic Acid / Q000737:chemistry
D006001:Glycoconjugates; D006046:Gold; D019158:N-Acetylneuraminic Acid