title: Sera of patients with systemic lupus erythematosus react with plasmodial antigens and can inhibit the in vitro growth of Plasmodium falciparum.
abstract: The acquisition of protective immunity in malaria is a slow process during which autoantibodies are produced. The present work aimed at studying a possible interference of autoimmune responses on malaria immune protection. This was done by investigating the presence of autoantibodies in the sera of malarious patients, by searching for reactivity of autoantibodies from autoimmune patients against plasmodial antigens, and by studying the effect of such antibodies on the in vitro growth of Plasmodium falciparum. Sera from systemic lupus erythematosus (SLE) and malaria patients were tested against autologous and plasmodial antigens. Out of the 109 SLE sera tested, 48 (44%) reacted against the parasite. In addition, 26 (47%) out of 55 randomly selected sera, mainly those containing anti-DNA and antinuclear autoantibodies, were able to inhibit parasite growth to some extent. Conversely, a high frequency (81%) of sera of malaria patients exhibited reactivity against autoantigens. The results show that patients with autoimmune processes can produce antibodies that recognize plasmodial antigens in the absence of plasmodial infection, that malaria patients can produce autoantibodies, that SLE sera can inhibit plasmodial growth in vitro, and that the presence of anti-DNA and antinuclear antibodies may be important in such anti-plasmodial activity. It is concluded that autoimmune responses may have influence on the protective immunity against malaria.
authors: Instituto Oswaldo Cruz and Center for Malaria Research and Training - Fiocruz, Rio de Janeiro, Brazil.
authors: Graziela Maria
authors: GM
authors: Zanini
authors: Leonardo Jose
authors: LJ
authors: De Moura Carvalho
authors: Karima
authors: K
authors: Brahimi
authors: Luiz Fernando
authors: LF
authors: De Souza-Passos
authors: Swami Jose
authors: SJ
authors: Guimarães
authors: Eduardo
authors: E
authors: Da Silva Machado
authors: Cesare
authors: C
authors: Bianco-Junior
authors: Evelyn Kety Pratt
authors: EK
authors: Riccio
authors: Maria Auxiliadora
authors: MA
authors: De Sousa
authors: Maria Das Gracas Costa
authors: MD
authors: Alecrim
authors: Nocy
authors: N
authors: Leite
authors: Pierre
authors: P
authors: Druilhe
authors: Claudio Tadeu
authors: CT
authors: Daniel-Ribeiro
mesh_terms: D000818:Animals; D000953:Antigens, Protozoan / Q000276:immunology* / Q000378:metabolism; D001323:Autoantibodies / Q000276:immunology* / Q000494:pharmacology; D003429:Cross Reactions; D006801:Humans; D007106:Immune Sera / Q000276:immunology* / Q000494:pharmacology; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000276:immunology; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000254:growth & development / Q000276:immunology*
chemical_list: D000953:Antigens, Protozoan; D001323:Autoantibodies; D007106:Immune Sera