Feline perforating dermatitis resembling human reactive perforating collagenosis: clinicopathological findings and outcome in four cases.
The clinicopathological findings of perforating dermatitis in two young and two adult cats are described. In all cases, the lesions were characterized by single or multiple papules and plaques, 0.5-3.0 cm in diameter, each containing a central, firm, exophytic, cone-shaped, yellow-orange keratotic plug, tightly adherent to the underlying skin. Removal of the protruding material was associated with bleeding and left the ulcerated surface exposed. In one case, the lesions showed a linear configuration and identical lesions occurred on the suture sites following biopsy. Histopathologically, the diagnosis was straightforward because of the presence of vertically orientated collagen bundles extruded from ulcerated, concave-shaped invaginations of the skin. In two cases, vitamin C administration failed to resolve the disease. In two cases, methyl-prednisolone acetate was used to manage relapsing episodes and vitamin C helped to reduce glucocorticoid requirements. In one case, treatment with methyl-prednisolone acetate only appeared to be curative. The fourth case was lost to follow-up immediately after the diagnosis.
Albanese
Francesco
F
Private practice, Clinica Veterinaria L'Arca, 80129 - Naples, Italy.
Tieghi
Chiara
C
De Rosa
Luigi
L
Colombo
Silvia
S
Abramo
Francesca
F
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001205:Ascorbic Acid / Q000627:therapeutic use; D002371:Cat Diseases / Q000473:pathology* / Q000628:therapy; D002415:Cats; D003872:Dermatitis / Q000473:pathology / Q000628:therapy / Q000662:veterinary*; D005260:Female; D008297:Male; D008775:Methylprednisolone / Q000031:analogs & derivatives / Q000627:therapeutic use; D000077555:Methylprednisolone Acetate
D000893:Anti-Inflammatory Agents; D000077555:Methylprednisolone Acetate; D001205:Ascorbic Acid; D008775:Methylprednisolone