Dysfunction in ABCB1A has only a weak effect on susceptibility to dextran sulfate sodium-induced colitis in SAM strains.
Genetic alterations in the gene for ATP-binding cassette, sub-family B (MDR/TAP), member 1A (ABCB1A) determine susceptibility to colitis in mice and humans. We investigated the influence of ABCB1A dysfunction on susceptibility to dextran sulfate sodium (DSS)-induced colitis by using Senescence-Accelerated Mouse (SAM) strains with a loss-of-function mutation in the Abcb1a gene (SAMR1, SAMP1, and SAMP6). Susceptibility to DSS colitis was different among SAM strains but on the whole was not different from other mouse strains with normal ABCB1A function. Thus, genetic factors other than loss of ABCB1A are more crucial in determining susceptibility to DSS colitis in SAM strains.
Zhang
Guohong
G
Department of Aging Biology, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, Asahi, Matsumoto, Japan.
Fu
Xiaoying
X
Takeda
Toshio
T
Higuchi
Keiichi
K
Mori
Masayuki
M
D018435:ATP Binding Cassette Transporter, Subfamily B; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D018528:ATP-Binding Cassette Transporters / Q000235:genetics* / Q000378:metabolism; D019588:Aging, Premature / Q000235:genetics*; D000818:Animals; D003092:Colitis / Q000139:chemically induced / Q000235:genetics* / Q000473:pathology; D003106:Colon / Q000187:drug effects / Q000473:pathology; D016264:Dextran Sulfate / Q000633:toxicity*; D004195:Disease Models, Animal; D020868:Gene Silencing; D020022:Genetic Predisposition to Disease; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D013047:Specific Pathogen-Free Organisms
D018435:ATP Binding Cassette Transporter, Subfamily B; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D018528:ATP-Binding Cassette Transporters; D016264:Dextran Sulfate; C507084:Abcb1b protein, mouse