Biology of charged particles.
Charged particles have moved from the physics laboratory to the clinic because of their advantageous dose profile and biologic effects. This brief review will summarize the basic phenomenological laboratory data that led to the successful clinical use of these modalities in selected tumor sites, and the emerging new genomic and proteomic research that have provided translational evidence for potential molecular mechanisms underlying some impressive clinical results.
Blakely
Eleanor A
EA
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720-8174, USA. EABlakely@lbl.gov
Chang
Polly Y
PY
D004307:Dose-Response Relationship, Radiation; D023281:Genomics; D006283:Health Physics; D006801:Humans; D007477:Ions; D009369:Neoplasms / Q000532:radiotherapy* / Q000628:therapy; D010316:Particle Size; D040901:Proteomics; D061766:Proton Therapy; D012062:Relative Biological Effectiveness; D057170:Translational Research, Biomedical
D007477:Ions