Efficient and diverse synthesis of indole derivatives.
A convergent 2-step procedure toward an array of indole derivatives involving an Ugi reaction and a Pictet-Spengler reaction is described. The reactions are versatile regarding different starting materials. Hexacyclic 24 can be produced with unprecedented complexity.
Liu
Haixia
H
Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA.
Dömling
Alexander
A
D002384:Catalysis; D002625:Chemistry, Organic / Q000379:methods*; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D003486:Cyanides / Q000737:chemistry; D015195:Drug Design; D005557:Formaldehyde / Q000737:chemistry; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D015394:Molecular Structure; D013237:Stereoisomerism; D014364:Tryptophan / Q000737:chemistry
D003486:Cyanides; D007211:Indoles; D005557:Formaldehyde; D014364:Tryptophan