title: [New mechanisms by which physical exercise improves insulin resistance in the skeletal muscle].
abstract: Insulin resistance of skeletal muscle glucose transport is a key-defect for the development of impaired glucose tolerance and type 2 diabetes. However, it is known that both an acute bout of exercise and chronic endurance exercise training can bring beneficial effects on insulin action in insulin-resistant states. However, little is currently known about the molecular effects of acute exercise on muscle insulin signaling in the post-exercise state in insulin-resistant organisms. This review provides new insight into the mechanism through which acute exercise restores insulin sensitivity, highlighting an important role for inflammatory proteins and S-nitrosation in the regulation of insulin signaling proteins in skeletal muscle.
authors: Departamento de Biociências, Faculdade de Educação Física, modalidade Saúde, Universidade Federal de São Paulo, Santos, SP, Brasil. rodrigosere@yahoo.com.br
authors: José Rodrigo
authors: JR
authors: Pauli
authors: Dennys Esper
authors: DE
authors: Cintra
authors: Claudio Teodoro de
authors: CT
authors: Souza
authors: Eduardo Rochette
authors: ER
authors: Ropelle
mesh_terms: D015444:Exercise / Q000502:physiology*; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D055504:Insulin Receptor Substrate Proteins / Q000378:metabolism; D007333:Insulin Resistance / Q000502:physiology*; D018482:Muscle, Skeletal / Q000378:metabolism*; D009566:Nitrates / Q000378:metabolism; D015538:Nitrosation; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D055504:Insulin Receptor Substrate Proteins; D009566:Nitrates; D005947:Glucose