title: Single-subject designs as a tool for evidence-based clinical practice: Are they unrecognised and undervalued?
abstract: One could be forgiven for thinking that the only road to evidence-based clinical practice is the application of results from randomised controlled trials (or systematic reviews of such). By contrast, single-subject designs in the context of evidence-based clinical practice are believed by many to be strange bedfellows. In this paper, we argue that single-subject designs play an important role in evidence-based clinical practice. We survey the contents of Neuropsychological Rehabilitation in relation to single-subject designs and tackle the main criticisms that have been levelled against them. We offer practical guidance for rating the methodological quality of single-subject designs and applying statistical techniques to measure treatment efficacy. These guides are equally applicable to research studies and everyday clinical practice with individual patients.
authors: Department of Neurology, Royal North Shore Hospital, Sydney, Australia. mperdices@nsccahs.health.gov.nsw.au
authors: Michael
authors: M
authors: Perdices
authors: Robyn L
authors: RL
authors: Tate
mesh_terms: D001927:Brain Diseases / Q000534:rehabilitation*; D001930:Brain Injuries / Q000534:rehabilitation; D019317:Evidence-Based Medicine / Q000379:methods*; D006801:Humans; D012046:Rehabilitation / Q000379:methods; D012107:Research Design