Locally-administered antibiotics in wounds in a limb.
We used a goat model of a contaminated musculoskeletal defect to determine the effectiveness of rapidly-resorbing calcium-sulphate pellets containing amikacin to reduce the local bacterial count. Our findings showed that this treatment eradicated the bacteria quickly, performed as well as standard polymethylmethacrylate mixed with an antibiotic and had many advantages over the latter. The pellets were prepared before surgery and absorbed completely. They released all of the antibiotic and did not require a subsequent operation for their removal. Our study indicated that locally administered antibiotics reduced bacteria within the wound rapidly. This method of treatment may have an important role in decreasing the rate of infection in contaminated wounds.
Branstetter
J G
JG
Extremity Trauma & Regenerative Medicine Task Area, 3400 Rawley East Chambers Avenue, San Antonio, Texas 78234, USA.
Jackson
S R
SR
Haggard
W O
WO
Richelsoph
K C
KC
Wenke
J C
JC
D000042:Absorption; D000583:Amikacin / Q000008:administration & dosage*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D002133:Calcium Sulfate / Q000008:administration & dosage*; D006041:Goats; D006614:Hindlimb / Q000187:drug effects / Q000293:injuries*
D000900:Anti-Bacterial Agents; D000583:Amikacin; D002133:Calcium Sulfate