title: Transformation of B cell lymphoma to histiocytic sarcoma: somatic mutations of PAX-5 gene with loss of expression cannot explain transdifferentiation.
abstract: Transdifferentiation of B cell lymphoma of germinal center cell origin to histiocytic sarcoma has recently been described but is a rare occurrence. The cause for loss of B cell differentiation in these lymphomas is unknown. We investigated whether somatic hypermutation of the PAX-5 gene, a transcription factor that is important for maintaining B cell identity and is frequently mutated in B cell lymphomas of germinal center cell origin, might be a cause for loss of PAX-5 expression and thus B cell phenotype. However, no somatic hypermutation of the PAX-5 gene was detected in the two cases we studied. The molecular basis for transdifferentiation of B cell lymphoma to histiocytic sarcoma remains therefore unresolved.
authors: Assia
authors: A
authors: Bassarova
authors: Gunhild
authors: G
authors: Trøen
authors: Alexander
authors: A
authors: Fosså
authors: Ida Munster
authors: IM
authors: Ikonomou
authors: Klaus
authors: K
authors: Beiske
authors: Jahn M
authors: JM
authors: Nesland
authors: Jan
authors: J
authors: Delabie