title: Assembly of Coenzyme Q10 nanostructure resembling nascent discoidal high density lipoprotein particle.
abstract: There are tremendous drug candidates that suffer from insolubility in water. In the present study, it is shown that Coenzyme Q10 (CoQ10), a model water-insoluble compound, can be nanoparticulated into a water-soluble form using apolipoprotein A-I (apoA-I). Similar to the way that apoA-I forms nascent discoidal high density lipoprotein (ndHDL) particles by bordering acyl chain tails of phospholipids, CoQ10 could be enclosed into the circle of a disk made of apoA-Is. The resulting nanostructure of CoQ10 and apoA-I was water-soluble with a size of approximately 12 nm in diameter and was physically more robust than liposome. We expect that the strategy suggested in this study can be exploited to assemble nano-sized, water-soluble structures of various water-insoluble drug candidates.
authors: School of Biotechnology and Bioengineering, Sungkyunkwan University, Suwon, Gyeongido 440-746, Republic of Korea.
authors: Jae-Yoon
authors: JY
authors: Shin
authors: Jae-Il
authors: JI
authors: Shin
authors: Jun-Seob
authors: JS
authors: Kim
authors: Yoo-Soo
authors: YS
authors: Yang
authors: Yunha
authors: Y
authors: Hwang
authors: Joo-Sung
authors: JS
authors: Yang
authors: Dongwoo
authors: D
authors: Shin
authors: Jin-Ho
authors: JH
authors: Seo
authors: Yong-Su
authors: YS
authors: Jin
authors: Yong-Cheol
authors: YC
authors: Park
authors: Jae-Sung
authors: JS
authors: Hwang
authors: Dae-Hyuk
authors: DH
authors: Kweon
mesh_terms: D016632:Apolipoprotein A-I / Q000737:chemistry*; D008075:Lipoproteins, HDL / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D010713:Phosphatidylcholines / Q000737:chemistry; D012995:Solubility; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000737:chemistry; D014867:Water / Q000737:chemistry*
chemical_list: D016632:Apolipoprotein A-I; D008075:Lipoproteins, HDL; D010713:Phosphatidylcholines; D014867:Water; D014451:Ubiquinone; C024989:coenzyme Q10; C028694:1-palmitoyl-2-oleoylphosphatidylcholine