title: Developmental exposure to PCBs, MeHg, or both: long-term effects on auditory function.
abstract: BACKGROUND
  Developmental exposure to polychlorinated biphenyls (PCBs) or methylmercury (MeHg) can result in a variety of neurotoxic effects, including long-term auditory deficits. However, little is known about the effects of combined exposure to PCBs and MeHg on auditory function.
  
  
  OBJECTIVE
  We developmentally exposed rats to PCBs and/or MeHg and assessed auditory function in adulthood to determine the effects of exposure to these contaminants individually and in combination.
  
  
  METHODS
  We exposed female Long-Evans rats to 1 or 3 mg/kg PCB in corn oil, 1.5 or 4.5 ppm MeHg in drinking water, or combined exposure to 1 mg/kg PCB + 1.5 ppm MeHg or 3 mg/kg PCB + 4.5 ppm MeHg. Controls received corn oil vehicle and unadulterated water. Dosing began 28 days before breeding and continued until weaning at postnatal day (PND) 21. Auditory function of the offspring was assessed at approximately PND 200 by measuring distortion product otoacoustic emissions (DPOAEs) and auditory brainstem responses (ABRs).
  
  
  RESULTS
  Groups exposed to PCBs alone had attenuated DPOAE amplitudes, elevated DPOAE thresholds, and elevated ABR thresholds compared with controls. Groups exposed to MeHg alone did not differ from controls. Unexpectedly, the effects of PCB exposure appeared to be attenuated by coexposure to MeHg.
  
  
  CONCLUSIONS
  Developmental exposure to PCBs can result in permanent hearing deficits, and the changes in DPOAE amplitudes and thresholds suggest a cochlear site of action. Coexposure to MeHg appeared to attenuate the PCB-related deficits, but the mechanism for this unexpected interaction remains to be determined.
authors: Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, Illinois 61802, USA.
authors: Brian E
authors: BE
authors: Powers
authors: Emily
authors: E
authors: Poon
authors: Helen J K
authors: HJ
authors: Sable
authors: Susan L
authors: SL
authors: Schantz
mesh_terms: D000818:Animals; D016057:Evoked Potentials, Auditory, Brain Stem / Q000187:drug effects*; D005260:Female; D018811:Maternal Exposure; D008767:Methylmercury Compounds / Q000633:toxicity*; D011078:Polychlorinated Biphenyls / Q000633:toxicity*; D011247:Pregnancy; D051381:Rats; D020318:Rats, Long-Evans
chemical_list: D008767:Methylmercury Compounds; D011078:Polychlorinated Biphenyls