Epstein-Barr virus-associated smooth muscle tumor of the iris in a patient with transplant: a case report and review of the literature.
Epstein-Barr virus infection has been linked to the development of smooth muscle tumors in immunocompromised patients with organ transplants and acquired immunodeficiency syndrome. A 52-year-old female recipient of a renal transplant presented with enlarging masses of the left iris. Incisional biopsy of the mass revealed a smooth muscle tumor of the iris. Epstein-Barr virus infection was confirmed by in situ hybridization for Epstein-Barr virus-encoded, small RNA in tumor cells. Eight months after total iridectomy the patient was free of disease. Although the prognosis and classification of Epstein-Barr virus-associated smooth muscle tumors are controversial, mortalities caused by these tumors are rare.
Yu
Le
L
Jules Stein Eye Institute, David Geffen School of Medicine, University of California, Los Angeles, 10833 Le Conte Ave, Los Angeles, CA 90095, USA.
Aldave
Anthony J
AJ
Glasgow
Ben J
BJ
D017088:AIDS-Related Opportunistic Infections; D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D018572:Disease-Free Survival; D020031:Epstein-Barr Virus Infections / Q000473:pathology / Q000821:virology*; D005260:Female; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D016867:Immunocompromised Host; D017403:In Situ Hybridization; D015811:Iris Neoplasms / Q000473:pathology / Q000601:surgery / Q000821:virology*; D016030:Kidney Transplantation; D008875:Middle Aged; D011183:Postoperative Complications; D012367:RNA, Viral; D018235:Smooth Muscle Tumor / Q000473:pathology / Q000601:surgery / Q000821:virology*
D012367:RNA, Viral