Ricinus communis biocompatibility histological study in the nose of Cebus apella monkeys.
Bone tissue lesions can be caused by congenital and acquired factors, and result in nasal deformities with cosmetic and functional repercussion. Surgical treatment in these cases frequently requires complex reconstructions and the use of biomaterials. The polyurethane derived from castor beans (Ricinus communis) has a favorable formulation in terms of ease of processing, flexibility, no emission of toxic vapors and low cost. Nonetheless, despite favorable results, studies about the use of castor beam polymer (Ricinus communis) assessing tissue reaction on the nasal dorsum are still missing in the literature.


OBJECTIVE
the goal of the present investigation is to histologically assess the Ricinus communis polymer implant biocompatibility with the nasal dorsum.


METHODS
experimental.


METHODS
we used four Cebus appela monkeys, in which we created a nasal dorsal defect in all the animals and there we placed the aforementioned implant. The animals were sacrificed 270 days after surgery and the samples were submitted to histological study.


RESULTS
in the histology analysis we did not observe the presence of foreign body granulomas or phagocytic cells. We also observed a progressive bone formation and maturation.


CONCLUSIONS
macroscopic and microscopic results showed that the castor oil polymer implant was biocompatible.
Dias
Paulo Cesar de Jesus
PC
Federal University of São Paulo. pcjdias@ig.com.br
Granato
Lidio
L
Ramalho
Lizeti de Toledo de Oliveira
Lde T
Oliveira
José Américo de
JA
Pretel
Hermes
H
D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use*; D018786:Bone Substitutes / Q000627:therapeutic use*; D002367:Ricinus communis / Q000737:chemistry*; D002368:Castor Oil / Q000627:therapeutic use*; D002428:Cebus; D008422:Materials Testing / Q000379:methods; D009295:Nasal Bone / Q000601:surgery*; D011140:Polyurethanes; D013997:Time Factors
D001672:Biocompatible Materials; D018786:Bone Substitutes; D011140:Polyurethanes; D002368:Castor Oil