[Free amino acid pool in rat blood plasma under different conditions of alcoholization and correction with L-NAME and L-arginine].
The features of disturbances of the free amino acid pool under conditions of alcoholization in different regimes and its correction with L-NAME and L-arginine have been studied in rats. The most pronounced dysbalance of free amino acid was observed in animals upon interrupted alcoholization. The treatment with L-NAME and L-arginine on the background of chronic and interrupted alcoholization was found to normalize most indices of the of free amino acid pool. However, only the treatment with L-arginine led to a decrease in the level of ammonium in the blood plasma.
Artemova
O V
OV
Lelevich
V V
VV
D000435:Alcoholic Intoxication / Q000097:blood* / Q000188:drug therapy; D000596:Amino Acids / Q000097:blood*; D000818:Animals; D001120:Arginine / Q000494:pharmacology*; D008297:Male; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology*; D020030:Nitric Oxide Donors / Q000494:pharmacology*; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors*; D051381:Rats
D000596:Amino Acids; D020030:Nitric Oxide Donors; D001120:Arginine; D019001:Nitric Oxide Synthase; D019331:NG-Nitroarginine Methyl Ester