Remodeling rodent models to mimic human type 1 diabetes.
Type 1 diabetes (T1D) occurs when the immune system attacks the insulin-producing beta cells located in the islets of Langerhans within the pancreas. Animal models have played a prominent role in developing an understanding of this disease process, through studies of genetic susceptibility, progression of hyperglycemia, and novel approaches to therapy. Here, we critically evaluate the currently available diabetic animal models and their propensity to match and predict disease outcomes in man as well as propose new in vitro and in vivo systems that may facilitate progress in the T1D field.
von Herrath
Matthias
M
Center for Type 1 Diabetes Research, La Jolla Institute for Allergy and Immunology, UCSD, La Jolla, CA 92037, USA. matthias@liai.org
Nepom
Gerald T
GT
D000818:Animals; D016207:Cytokines / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology / Q000378:metabolism / Q000628:therapy*; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D016688:Mice, Inbred NOD; D051381:Rats; D011913:Rats, Inbred BB; D013601:T-Lymphocytes / Q000276:immunology
D016207:Cytokines