Screening of a branched peptide library with HIV-1 TAR RNA.
The recognition that RNA is more than just an intermediate in the information transfer from genetic code to fully functional protein has placed it at the forefront of chemical research. RNA is important because of its vital role in regulating transcription, translation, splicing, replication and catalysis. Consequently, molecules that can bind to RNA and control its function have potential as powerful tools in biology and medicine. Herein, we report the discovery of HIV-1 TAR RNA-selective ligands using an on-bead screening of a library of 4096 branched peptides.
Bryson
David I
DI
Virginia Tech, Department of Chemistry, Blacksburg, VA 24061, USA.
Zhang
Wenyu
W
Ray
W Keith
WK
Santos
Webster L
WL
D055808:Drug Discovery / Q000379:methods; D016325:HIV Long Terminal Repeat; D015497:HIV-1 / Q000235:genetics*; D019151:Peptide Library; D010455:Peptides / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics*; D012367:RNA, Viral / Q000235:genetics*; D015203:Reproducibility of Results; D013050:Spectrometry, Fluorescence
D019151:Peptide Library; D010455:Peptides; D012333:RNA, Messenger; D012367:RNA, Viral