title: Susceptibility of mantle cell lymphomas to reovirus oncolysis.
abstract: Mantle cell lymphoma (MCL) an incurable B-cell, non-Hodgkin lymphoma (NHL) urgently requires new treatments. We assessed reovirus mediated oncolysis in a panel of human MCL cell lines. In vitro, we found the cytopathic effect of reovirus infection ranged from high to very limited and correlated with levels of Ras activation. In vivo, a single reovirus injection intra-tumorally resulted in complete regression of both the injected and the contra-lateral tumor in a subcutaneous bi-tumor model, in one out of three cell lines tested. Reovirus treatment of MCL seems feasible but will need to be guided by the presence of molecular determinants of reovirus susceptibility.
authors: Translational Research Laboratory, Tom Baker Cancer Centre, Calgary, Alberta, Canada.
authors: Tommy
authors: T
authors: Alain
authors: Huong
authors: H
authors: Muzik
authors: Shannon
authors: S
authors: Otsuka
authors: Salina
authors: S
authors: Chan
authors: Tony
authors: T
authors: Magliocco
authors: Roman
authors: R
authors: Diaz
authors: Peter A
authors: PA
authors: Forsyth
authors: Don
authors: D
authors: Morris
authors: Gwyn
authors: G
authors: Bebb
mesh_terms: D000818:Animals; D006801:Humans; D006868:Hydrolysis; D020522:Lymphoma, Mantle-Cell / Q000628:therapy*; D051379:Mice; D050130:Oncolytic Virotherapy; D012087:Reoviridae / Q000502:physiology*