title: The effects of chronic dietary phenytoin on 5-HT and 5-HIAA levels in rats.
abstract: Rats were given, by means of the diet, phenytoin (PHT) every day for either 4 (400-800 mg/kg) or 14 (400 mg/kg) weeks. Serum values of PHT in both cases were in the pharmacological range (10-15 microg/ml). An increase in brain 5-HIAA levels was noted after 4 but not 14 weeks of PHT administration. There was no change in brain 5-HT levels. In accordance with results in epileptic patients, it appears that under some circumstances, PHT can increase 5-HIAA levels, but the mechanism of this action is unknown.
authors: Hôtel-Dieu Hospital, Neurology Service, Section of Clinical and Experimental Neuropsychology, Montreal, Canada H2W 1T8.
authors: C
authors: C
authors: Joyal
authors: R
authors: R
authors: Lalonde
authors: M I
authors: MI
authors: Botez