title: Acromegaly associated with multiple tumors.
abstract: A 56-year-old man was admitted to our hospital for the surgical removal of renal cell carcinoma (RCC). He was diagnosed with acromegaly due to his characteristic clinical features, endocrine data, and the presence of pituitary tumor. He was found to have colon cancer and follicular thyroid tumor. Pathological examination of the pituitary tumor after transsphenoidal surgery was compatible with growth hormone (GH)-secreting pituitary adenoma. We also detected the transcripts and/or immunoreactivity of GH/insulin-like growth factor I components in the tumor specimen. This is a rare case of acromegaly associated with multiple tumors, including RCC, colon cancer and thyroid tumor.
authors: Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School, Tokyo.
authors: Naoko
authors: N
authors: Sekizawa
authors: Eri
authors: E
authors: Hayakawa
authors: Kyoichiro
authors: K
authors: Tsuchiya
authors: Takanobu
authors: T
authors: Yoshimoto
authors: Takumi
authors: T
authors: Akashi
authors: Takeshi
authors: T
authors: Fujii
authors: Shozo
authors: S
authors: Yamada
authors: Yukio
authors: Y
authors: Hirata
mesh_terms: D000172:Acromegaly / Q000209:etiology*; D001483:Base Sequence; D002292:Carcinoma, Renal Cell / Q000150:complications / Q000235:genetics / Q000378:metabolism; D003110:Colonic Neoplasms / Q000150:complications / Q000235:genetics / Q000378:metabolism; D017931:DNA Primers / Q000235:genetics; D015870:Gene Expression; D006801:Humans; D007150:Immunohistochemistry; D007334:Insulin-Like Growth Factor I / Q000235:genetics / Q000378:metabolism; D007680:Kidney Neoplasms / Q000150:complications / Q000235:genetics / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000150:complications* / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism; D010911:Pituitary Neoplasms / Q000150:complications / Q000235:genetics / Q000378:metabolism; D017526:Receptor, IGF Type 1 / Q000235:genetics / Q000378:metabolism; D011986:Receptors, Somatotropin / Q000235:genetics / Q000378:metabolism; D013964:Thyroid Neoplasms / Q000150:complications / Q000235:genetics / Q000378:metabolism
chemical_list: D017931:DNA Primers; D011986:Receptors, Somatotropin; D007334:Insulin-Like Growth Factor I; D017526:Receptor, IGF Type 1