From bending DNA to diabetes: the curious case of HMGA1.
Although mice lacking the architectural DNA binding factor HMGA1 are diabetic and express very low levels of the insulin receptor, they have increased insulin sensitivity. A study in BMC Biology now suggests that changes in circulating retinol binding protein partly account for this paradox.
Semple
Robert K
RK
Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0QR, UK. rks16@cam.ac.uk
D000818:Animals; D004247:DNA / Q000235:genetics / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics / Q000378:metabolism*; D005786:Gene Expression Regulation; D024003:HMGA Proteins / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007333:Insulin Resistance; D051379:Mice; D054839:Retinol-Binding Proteins, Plasma / Q000235:genetics / Q000378:metabolism
D024003:HMGA Proteins; C502487:Rbp4 protein, mouse; D054839:Retinol-Binding Proteins, Plasma; D004247:DNA