title: Women, loneliness, and incident coronary heart disease.
abstract: OBJECTIVE
  To examine associations between loneliness and risk of incident coronary heart disease (CHD) over a 19-year follow-up period in a community sample of men and women. Loneliness, the perceived discrepancy between actual and desired social relationships, has been linked to several adverse health outcomes. However, no previous research has prospectively examined the association between loneliness and incident CHD in a community sample of men and women.
  
  
  METHODS
  Hypotheses were examined using data from the First National Health and Nutrition Survey and its follow-up studies (n = 3003). Loneliness, assessed by one item from the Center for Epidemiologic Studies of Depression scale, and covariates were derived from baseline interviews. Incident CHD was derived from hospital records/death certificates over 19 years of follow-up. Hypotheses were evaluated, using Cox proportional hazards models.
  
  
  RESULTS
  Among women, high loneliness was associated with increased risk of incident CHD (high: hazard ratio = 1.76, 95% Confidence Interval = 1.17-2.63; medium: hazard ratio = 0.98, 95% Confidence Interval = 0.64-1.49; reference: low), controlling for age, race, education, income, marital status, hypertension, diabetes, cholesterol, physical activity, smoking, alcohol use, systolic and diastolic blood pressures, and body mass index. Findings persisted additionally controlling for depressive symptoms. No significant associations were observed among men.
  
  
  CONCLUSIONS
  Loneliness was prospectively associated with increased risk of incident CHD, controlling for multiple confounding factors. Loneliness among women may merit clinical attention, not only due to its impact on quality of life but also its potential implications for cardiovascular health.
authors: Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. thurstonrc@upmc.edu
authors: Rebecca C
authors: RC
authors: Thurston
authors: Laura D
authors: LD
authors: Kubzansky
mesh_terms: D000328:Adult; D000368:Aged; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000453:epidemiology; D003327:Coronary Disease / Q000175:diagnosis / Q000453:epidemiology* / Q000523:psychology; D003863:Depression / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D005500:Follow-Up Studies; D006304:Health Status; D006306:Health Surveys; D006801:Humans; D008132:Loneliness / Q000523:psychology*; D008137:Longitudinal Studies; D017533:Marital Status; D008875:Middle Aged; D012307:Risk Factors; D011795:Surveys and Questionnaires; D014930:Women / Q000523:psychology*; D016387:Women's Health