title: HLA-DRB1 alleles are associated with the clinical course of disease and steroid dependence in Mexican patients with ulcerative colitis.
abstract: OBJECTIVE
  The aim of this study was to study the association between the HLA-DRB1 alleles and the clinical course of ulcerative colitis (UC).
  
  
  METHODS
  Seventy-five Mexican patients with UC were studied. High resolution HLA typing was performed using Polymerase Chain Reaction-Sequence Specific Oligonucleotide PCR-SSO reverse dot blot and Polymerase Chain Reaction-single specific primer PCR-SSP. Molecular typing techniques were applied to define HLA-DRB1 alleles.
  
  
  RESULTS
  Seventy-five patients (36 female patients, 39 male patients) were studied. Significant associations were found between some HLA-DRB1 alleles and the clinical course of disease: initial active and then inactive and the HLA-DRB1*14 allele (P = 0.03; OR = 4.63; 95% CI: 1.08-21.23); and HLA-DRB1*08 allele (P = 0.04; OR = 4.34; 95% CI: 1.9-33.3). On the other hand, the HLA-DRB1*07 (P = 0.001; OR = 9.76 95% CI: 1.55-65.56) was significantly associated with steroid dependence in UC patients.
  
  
  CONCLUSIONS
  This study suggests that HLA-DRB1 alleles were associated with the clinical course of disease and steroid dependence in UC patients.
authors: Department of Gastroenterology, Instituto Nacional de Ciencias Medicas y Nutricion, Mexico City, Mexico. kazuofurusho@hotmail.com
authors: J K
authors: JK
authors: Yamamoto-Furusho
authors: L
authors: L
authors: Rodríguez-Bores
authors: J
authors: J
authors: Granados
mesh_terms: D000328:Adult; D000483:Alleles; D003093:Colitis, Ulcerative / Q000188:drug therapy* / Q000235:genetics* / Q000276:immunology; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; D006801:Humans; D008297:Male; D008800:Mexico; D058889:Molecular Typing; D016133:Polymerase Chain Reaction; D013256:Steroids / Q000627:therapeutic use
chemical_list: D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; D013256:Steroids