title: Long-lasting desynchronization in rat hippocampal slice induced by coordinated reset stimulation.
abstract: In computational models it has been shown that appropriate stimulation protocols may reshape the connectivity pattern of neural or oscillator networks with synaptic plasticity in a way that the network learns or unlearns strong synchronization. The underlying mechanism is that a network is shifted from one attractor to another, so that long-lasting stimulation effects are caused which persist after the cessation of stimulation. Here we study long-lasting effects of multisite electrical stimulation in a rat hippocampal slice rendered epileptic by magnesium withdrawal. We show that desynchronizing coordinated reset stimulation causes a long-lasting desynchronization between hippocampal neuronal populations together with a widespread decrease in the amplitude of the epileptiform activity. In contrast, periodic stimulation induces a long-lasting increase in both synchronization and amplitude.
authors: Institute of Neuroscience and Medicine-Neuromodulation (INM-7), Research Center Jülich, D-52425 Jülich, Germany.
authors: P A
authors: PA
authors: Tass
authors: A N
authors: AN
authors: Silchenko
authors: C
authors: C
authors: Hauptmann
authors: U B
authors: UB
authors: Barnikol
authors: E-J
authors: EJ
authors: Speckmann
mesh_terms: D000818:Animals; D004558:Electric Stimulation; D004566:Electrodes; D004827:Epilepsy / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology; D006624:Hippocampus / Q000473:pathology / Q000503:physiopathology*; D066298:In Vitro Techniques; D008274:Magnesium / Q000378:metabolism / Q000494:pharmacology; D009474:Neurons / Q000378:metabolism; D051381:Rats; D013997:Time Factors
chemical_list: D008274:Magnesium