New carvotanacetone derivatives from Sphaeranthus africanus.
The dichloromethane extract of the air-dried leaves of Sphaeranthus africanus afforded four new carvotanacetone derivatives (1, 2, 3A, and 3B). Their structures were elucidated by extensive 1D and 2D NMR spectroscopy. Compounds 1- 3 exhibited antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa and antifungal activity against Candida albicans, Trichophyton mentagrophytes and Aspergillus niger.
Ragasa
Consolacion Y
CY
Chemistry Department, De La Salle University and Center for Natural Sciences and Ecological Research, De La Salle University, Manila, Phillipines. ragasac@dlsu.edu.ph
Tsai
Po-Wei
PW
Galvez
Cecilia T
CT
Shen
Chien-Chang
CC
D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001234:Aspergillus niger / Q000187:drug effects; D019659:Asteraceae / Q000737:chemistry*; D002176:Candida albicans / Q000187:drug effects; D005027:Ethylene Oxide / Q000031:analogs & derivatives* / Q000737:chemistry*; D005658:Fungi / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology; D018515:Plant Leaves; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D013211:Staphylococcus aureus / Q000187:drug effects*; D014249:Trichophyton / Q000187:drug effects
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D010936:Plant Extracts; D005027:Ethylene Oxide