title: Cytokine and antibody profiles in 1-year-old children vaccinated with either acellular or whole-cell pertussis vaccine during infancy.
abstract: Two different types of pertussis vaccines are currently available to protect children against whooping cough, the first-generation whole-cell (Pw) vaccines and the more recent acellular (Pa) vaccines. Both types provide good protection, yet induce different types of immune responses in 6-month-old infants, with a strong Th1 response induced by Pw vaccines compared to a mixed Th1/Th2 response and a delay in non-specific IFN-gamma secretions after the administration of Pa vaccines. We show here that at 13 months of age, most Pw- or Pa-vaccinated children display Bordetella pertussis-specific T-cell responses, in addition to significant antibody levels, although a higher Th2/Th1 cytokine ratio remained in Pa recipients compared to Pw recipients. In contrast, the proportion of children with tetanus toxin-specific T-cell responses was lower in Pa than in Pw vaccine recipients, although most children had protective anti-tetanus toxin IgG levels. In addition, the global Th2 bias observed in 6-month-old infants vaccinated with a Pa vaccine was normalized at 13 months.
authors: Laboratory of Vaccinology and Mucosal Immunity, Université Libre de Bruxelles (U.L.B.), 808 route de Lennik, 1070 Brussels, Belgium.
authors: V
authors: V
authors: Dirix
authors: V
authors: V
authors: Verscheure
authors: T
authors: T
authors: Goetghebuer
authors: M
authors: M
authors: Hainaut
authors: A S
authors: AS
authors: Debrie
authors: C
authors: C
authors: Locht
authors: F
authors: F
authors: Mascart
mesh_terms: D000907:Antibodies, Bacterial / Q000097:blood* / Q000276:immunology; D002478:Cells, Cultured; D016207:Cytokines / Q000097:blood* / Q000276:immunology; D005500:Follow-Up Studies; D006801:Humans; D007111:Immunity, Cellular; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D007223:Infant; D007963:Leukocytes, Mononuclear / Q000276:immunology; D010567:Pertussis Vaccine / Q000276:immunology*; D013745:Tetanus Toxoid / Q000276:immunology; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology; D022282:Vaccines, Acellular / Q000276:immunology; D014917:Whooping Cough / Q000276:immunology / Q000517:prevention & control*
chemical_list: D000907:Antibodies, Bacterial; D016207:Cytokines; D007074:Immunoglobulin G; D010567:Pertussis Vaccine; D013745:Tetanus Toxoid; D022282:Vaccines, Acellular