Predictors of early inactive disease in a juvenile idiopathic arthritis cohort: results of a Canadian multicenter, prospective inception cohort study.
OBJECTIVE
To determine early predictors of 6-month outcomes in a prospective cohort of patients with juvenile idiopathic arthritis (JIA).


METHODS
Patients selected were those enrolled in an inception cohort study of JIA, the Research in Arthritis in Canadian Children Emphasizing Outcomes Study, within 6 months after diagnosis. The juvenile rheumatoid arthritis core criteria set and quality of life measures were collected at enrollment and 6 months later. Outcomes evaluated included inactive disease, Juvenile Arthritis Quality of Life Questionnaire (JAQQ) scores, and Childhood Health Assessment Questionnaire (C-HAQ) scores at 6 months.


RESULTS
Thirty-three percent of patients had inactive disease at 6 months. Onset subtype and most baseline core criteria set measures correlated with all 3 outcomes. Relative to oligoarticular JIA, the risks of inactive disease were lower for enthesitis-related arthritis, polyarthritis rheumatoid factor (RF)-negative JIA, and polyarthritis RF-positive JIA, and were similar for psoriatic arthritis. In multiple regression analyses, the baseline JAQQ score was an independent predictor of all 3 outcomes. Other independent baseline predictors included polyarthritis RF-negative and systemic JIA for inactive disease; C-HAQ score and polyarthritis RF-positive JIA for the 6-month C-HAQ score; and active joint count, pain, and time to diagnosis for the 6-month JAQQ score.


CONCLUSIONS
Clinical measures soon after diagnosis predict short-term outcomes for patients with JIA. The JAQQ is a predictor of multiple outcomes. Time to diagnosis affects quality of life in the short term.
Oen
Kiem
K
University of Manitoba, Winnipeg, Manitoba, Canada. koen@exchange.hsc.mb.ca
Tucker
Lori
L
Huber
Adam M
AM
Miettunen
Paivi
P
Scuccimarri
Rosie
R
Campillo
Sarah
S
Cabral
David A
DA
Feldman
Brian M
BM
Tse
Shirley
S
Chédeville
Gaëlle
G
Spiegel
Lynn
L
Schneider
Rayfel
R
Lang
Bianca
B
Ellsworth
Janet
J
Ramsey
Suzanne
S
Dancey
Paul
P
Silverman
Earl
E
Chetaille
Anne-Laure
AL
Cameron
Bonnie
B
Johnson
Nicole
N
Dorval
Jean
J
Petty
Ross E
RE
Duffy
Karen Watanabe
KW
Boire
Gilles
G
Haddad
Elie
E
Houghton
Kristin
K
Saint-Cyr
Claire
C
Turvey
Stuart E
SE
Benseler
Susanne
S
Cheang
Mary
M
Yeung
Rae S M
RS
Duffy
Ciarán M
CM
D000293:Adolescent; D001171:Arthritis, Juvenile / Q000175:diagnosis / Q000503:physiopathology* / Q000534:rehabilitation*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006304:Health Status; D006801:Humans; D007223:Infant; D008297:Male; D011237:Predictive Value of Tests; D011446:Prospective Studies; D011788:Quality of Life; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires