Structure and potential function of gamma-aminobutyrate type A receptor-associated protein.
The gamma-aminobutyrate type A receptor-associated protein (GABARAP) is a ubiquitin-like modifier, and is implicated in a variety of membrane trafficking and fusion events that are crucial to synaptic plasticity, autophagy and apoptosis. However, important aspects of GABARAP function and regulation remain poorly understood. We review the current state of knowledge about GABARAP, highlighting newly-identified GABARAP ligands, and discuss the possible physiological relevance of each ligand interaction.
Mohrlüder
Jeannine
J
Institut für Strukturbiologie und Biophysik (ISB-3), Forschungszentrum Jülich, Germany. j.mohrlueder@fz-juelich.de
Schwarten
Melanie
M
Willbold
Dieter
D
D048868:Adaptor Proteins, Signal Transducing / Q000737:chemistry / Q000502:physiology*; D000818:Animals; D051017:Apoptosis Regulatory Proteins; D000071190:Autophagy-Related Protein 8 Family; D037282:Calreticulin / Q000502:physiology; D002352:Carrier Proteins / Q000502:physiology; D006801:Humans; D008024:Ligands; D008565:Membrane Proteins / Q000502:physiology; D008840:Microfilament Proteins / Q000502:physiology; D008869:Microtubule-Associated Proteins / Q000737:chemistry / Q000502:physiology*; D009419:Nerve Tissue Proteins / Q000502:physiology; D011963:Receptors, GABA-A / Q000502:physiology
D048868:Adaptor Proteins, Signal Transducing; D051017:Apoptosis Regulatory Proteins; D000071190:Autophagy-Related Protein 8 Family; D037282:Calreticulin; D002352:Carrier Proteins; C116741:GABARAP protein, human; C498698:GABARAPL2 protein, human; C546279:GABRG2 protein, human; C491310:GRIP1 protein, human; D008024:Ligands; D008565:Membrane Proteins; D008840:Microfilament Proteins; D008869:Microtubule-Associated Proteins; D009419:Nerve Tissue Proteins; D011963:Receptors, GABA-A; C073441:gephyrin