Release of PLGA-encapsulated dexamethasone from microsphere loaded porous surfaces.
The aim of the present study was to investigate the morphology and function of a drug eluting metallic porous surface produced by the immobilization of poly lactide-co-glycolide microspheres bearing dexamethasone onto plasma electrolytically oxidized Ti-6Al-7Nb medical alloy. Spheres of 20 microm diameter were produced by an oil-in-water emulsion/solvent evaporation method and thermally immobilized onto titanium discs. The scanning electron microscopy investigations revealed that the size distribution and morphology of the attached spheres had not changed significantly. The drug release profiles following degradation in phosphate buffered saline for 1000 h showed that, upon immobilisation, the spheres maintained a sustained release, with a triphasic profile similar to the non-attached system. The only significant change was an increased release rate during the first 100 h. This difference was attributed to the effect of thermal attachment of the spheres to the surface.
Dawes
G J S
GJ
Department of Materials Science and Engineering, Delft University of Technology, Delft, The Netherlands. G.J.S.Dawes@tudelft.nl
Fratila-Apachitei
L E
LE
Necula
B S
BS
Apachitei
I
I
Witkamp
G J
GJ
Duszczyk
J
J
D020341:Absorbable Implants; D002214:Capsules / Q000737:chemistry / Q000493:pharmacokinetics; D020099:Coated Materials, Biocompatible / Q000737:chemistry; D003907:Dexamethasone / Q000493:pharmacokinetics*; D016503:Drug Delivery Systems; D019344:Lactic Acid / Q000737:chemistry* / Q000378:metabolism*; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D010316:Particle Size; D011100:Polyglycolic Acid / Q000737:chemistry* / Q000378:metabolism*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D016062:Porosity; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry
D002214:Capsules; D020099:Coated Materials, Biocompatible; C009495:titanium dioxide; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D003907:Dexamethasone; D014025:Titanium