[Clinical observation of heparin-induced thrombocytopenia].
OBJECTIVE
To explore the treatment of heparin-induced thrombocytopenia (HIT) in venous thromboembolism.


METHODS
A total of 202 patients with venous thromboembolism without anticoagulation contraindications were enrolled. All of them were treated with low molecular weight heparin (LMWH) and/or unfractionated heparin (UFH). The peripheral blood cells were examined regularly.


RESULTS
HIT occurred in 6 patients. And argatroban was used to treat HIT. The overall incidence rate of HIT in this study was 2.97%. The time of occurrence of HIT was about Days 3 - 9 after using heparin. The platelet recovered to the basic level at Days 3 - 7 after withdrawing heparin and initiating argatroban.


CONCLUSIONS
The count of platelet should be measured in the patients receiving regular LMWH and/or UFH therapy. And the above regimen should be discontinued timely when the platelet count declined progressively by over 50%. Argatroban was effective.
Tian
Hong-yan
HY
Department of Cardiology and Peripheral Vascular Diseases, First Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an, 710061, China. tianhhyy@mail.xjtu.edu.cn
Meng
Yan
Y
Zhang
Jun-bo
JB
Ma
Qiang
Q
Cheng
Ge-sheng
GS
Fan
Fen-ling
FL
Wang
Jun
J
Wan
Hong-mei
HM
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000009:adverse effects* / Q000627:therapeutic use; D001120:Arginine / Q000031:analogs & derivatives; D005260:Female; D006493:Heparin / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D010875:Pipecolic Acids / Q000627:therapeutic use; D010976:Platelet Count; D013449:Sulfonamides; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000188:drug therapy; D054556:Venous Thromboembolism / Q000188:drug therapy; D055815:Young Adult
D000925:Anticoagulants; D010875:Pipecolic Acids; D013449:Sulfonamides; D006493:Heparin; D001120:Arginine; C031942:argatroban