title: Hypothalamic lipoma associated with severe obesity. Report of 2 cases.
abstract: The association between hypothalamic dysfunction and obesity is well documented in both clinical and experimental models. The authors describe 2 children who developed obesity that could not be explained by endocrinological, genetic, or eating disorders. In both cases, cranial MR imaging revealed the typical appearance of a lipoma in the paramedian hypothalamus. In the absence of other etiologies, the authors hypothesized that in these 2 children obesity was caused by their hypothalamic lipomas. To the authors' knowledge, these are the first cases of hypothalamic lipomas likely to be causing obesity that have been described in children. These cases highlight the importance of performing cranial MR imaging in children with otherwise unexplained obesity.
authors: Department of Pediatric Neurosurgery, Necker Hopsital, Universite Paris Descaretes, Paris, France. stephanie.puget@nck.aphp.fr
authors: Stéphanie
authors: S
authors: Puget
authors: Matthew R
authors: MR
authors: Garnett
authors: Delphine
authors: D
authors: Leclercq
authors: Graziella
authors: G
authors: Pinto-Primard
authors: Dinane
authors: D
authors: Samara-Boustani
authors: Christian
authors: C
authors: Sainte-Rose
authors: David
authors: D
authors: Genevieve
authors: Michel
authors: M
authors: Polak
authors: Pascale
authors: P
authors: De Lonlay
authors: Francis
authors: F
authors: Brunelle
authors: Alim Louis
authors: AL
authors: Benabid
authors: Nathalie
authors: N
authors: Boddaert
mesh_terms: D002648:Child; D002675:Child, Preschool; D006801:Humans; D007029:Hypothalamic Neoplasms / Q000150:complications* / Q000473:pathology*; D008067:Lipoma / Q000150:complications* / Q000473:pathology*; D008297:Male; D009765:Obesity / Q000209:etiology* / Q000473:pathology