title: Exercise training provides cardioprotection via a reduction in reactive oxygen species in rats submitted to myocardial infarction induced by isoproterenol.
abstract: Exercise training has demonstrated cardioprotection effects. However, the exact mechanism behind this effect is not is clear. The present study evaluated the effects of 12 weeks of previous treadmill training on the levels of oxidative damage, antioxidant enzyme activity and injury in the myocardium of rats submitted to infarction induced by isoproterenol (ISO). Isoproterenol treatment (80 mg/kg given over 2 days in two equal doses) caused arrhythmias and 60% mortality within 24 h of the last injection in the control group (C + ISO) group when compared with the saline control group (saline). Creatine Kinase--MB levels were markedly increased in hearts from ISO-treated animals in the C + ISO group. Twelve weeks of treadmill training reduced superoxide production, lipid peroxidation levels and protein carbonylation in these animals, as well as increasing the activities and expressions of SOD and CAT. Previous training also reduced CK-MB levels and numbers of deaths by 40%, preventing the deleterious effects of ISO. Based on the data obtained in this study, it is suggested that 12-week treadmill training increases antioxidant enzymes, decreases oxidative damage and reduces the degree of infarction induced by ISO in the hearts of male rats.
authors: Exercise Biochemistry and Physiology Laboratory, University of Southern Santa Catarina, Criciuma, SC, Brazil.
authors: Marisa J S
authors: MJ
authors: Frederico
authors: Simoni L
authors: SL
authors: Justo
authors: Gabrielle
authors: G
authors: Da Luz
authors: Sabrina
authors: S
authors: Da Silva
authors: Cleber
authors: C
authors: Medeiros
authors: Viviane A
authors: VA
authors: Barbosa
authors: Luciano A
authors: LA
authors: Silva
authors: Carina R
authors: CR
authors: Boeck
authors: Ricardo A
authors: RA
authors: De Pinho
authors: Claudio T
authors: CT
authors: De Souza
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D002374:Catalase / Q000378:metabolism; D052279:Creatine Kinase, MB Form / Q000097:blood; D004195:Disease Models, Animal; D007545:Isoproterenol; D008297:Male; D009203:Myocardial Infarction / Q000139:chemically induced / Q000201:enzymology / Q000378:metabolism* / Q000517:prevention & control*; D018384:Oxidative Stress / Q000502:physiology; D010805:Physical Conditioning, Animal / Q000502:physiology*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D015415:Biomarkers; D017382:Reactive Oxygen Species; D002374:Catalase; D013482:Superoxide Dismutase; D052279:Creatine Kinase, MB Form; D007545:Isoproterenol