Corpus predominant gastritis: what does it mean?
OBJECTIVE
To summarize this year's relevant literature on the causes and mechanisms of autoimmune gastritis.


RESULTS
It is increasingly recognized that parietal cell antibodies, previously assumed exclusive to autoimmune gastritis, are associated with Helicobacter pylori infection. Successful H. pylori eradication with antibiotic treatment decreases antiparietal cell antibodies. Interestingly, vitamin B(12) deficiency, previously associated with autoimmune gastritis, is increasingly described in the elderly, irrespective of H. pylori status. Autoimmune gastritis that mostly affects patients of Scandinavian descent, was reported this year from China, and corpus predominant gastritis (autoimmune associated) was reported from Japan. It is difficult to evaluate the role played by genetics, increased use of proton pump inhibitors, and H. pylori infection, as current patient work-up does not regularly include screening for parietal cell and intrinsic-factor antibodies. As these clinicopathologic changes are seen in both H. pylori-positive patients, and in H. pylori-naïve patients, the debate continues for mechanisms involved in H. pylori-naïve patients.


CONCLUSIONS
The clinical features commonly associated with autoimmune gastritis are increasingly seen in the elderly, irrespective of H. pylori status. Though some patients are genetically predisposed, long-term proton pump inhibitor use increases the prevalence of clinicopathologic features irrespective of genetic tendency.
El-Zimaity
Hala
H
Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada. zimaity@mcmaster.ca
D000367:Age Factors; D001327:Autoimmune Diseases / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D005756:Gastritis / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D016481:Helicobacter Infections / Q000235:genetics / Q000276:immunology; D016480:Helicobacter pylori / Q000276:immunology; D006801:Humans; D010295:Parietal Cells, Gastric / Q000276:immunology; D054328:Proton Pump Inhibitors / Q000494:pharmacology; D012307:Risk Factors; D014806:Vitamin B 12 Deficiency / Q000276:immunology
D054328:Proton Pump Inhibitors