[Clinical features of pregnancy and lactation-associated osteoporosis: analysis of 4 cases].
OBJECTIVE
To analyze the clinical features of pregnancy and lactation-associated osteoporosis (PLO).


METHODS
The clinical data of 4 patients with PLO were retrospectively analyzed.


RESULTS
Bone pain and limitation of motion appeared within 2 months after childbirth in these 4 patients. X-ray films showed multiple vertebral fractures of thoracic and/or lumbar spine. Three of the 4 patients had positive family history of osteoporosis or low trauma fractures. After the diagnosis of PLO was confirmed, lactation was discontinued, and treatment of calcium, active vitamin D analogues, and bisphosphonates were initiated. After these managements, no new fracture occurred and the BMD at L(2-4) was markedly increased by 12.7% - 22.7% during their follow-up period of 1 - 4 years.


CONCLUSIONS
Women with positive family history of osteoporosis or low trauma fractures may be susceptible to PLO. PLO should be considered when lumbar or back pain occur during pregnancy and lactation. Besides calcium and active vitamin D analogues, anti-resorptive agents (bisphosphonate or calcitonin) may be effective on PLO.
He
Xiao-dong
XD
Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China.
Xia
Wei-bo
WB
Xing
Xiao-ping
XP
Li
Mei
M
Jiang
Yan
Y
Wang
Ou
O
Xu
Ling-ling
LL
Xu
Jian-ping
JP
D000328:Adult; D015519:Bone Density; D002118:Calcium / Q000627:therapeutic use; D004164:Diphosphonates / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007774:Lactation; D010024:Osteoporosis / Q000188:drug therapy* / Q000209:etiology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D014807:Vitamin D / Q000627:therapeutic use
D004164:Diphosphonates; D014807:Vitamin D; D002118:Calcium