title: Safety and efficacy of lamivudine after radiofrequency ablation in patients with hepatitis B virus-related hepatocellular carcinoma.
abstract: BACKGROUND
  Antiviral treatments for hepatitis B virus (HBV) are not established in patients with HBV-related hepatocellular carcinoma (HCC).
  
  
  OBJECTIVE
  To investigate the safety and efficacy of lamivudine (LAM) in patients with HBV-related HCC who were treated with radiofrequency ablation (RFA).
  
  
  METHODS
  RFA-treated patients with HBV-related HCC were retrospectively divided into those who received LAM (LAM group) and those who did not (nontreatment group). The first-year changes in serum alanine aminotransferase (ALT), total bilirubin (TBIL), and albumin (ALB) levels were compared in corresponding subsets based on Child-Pugh classification (Mann-Whitney U test) and between one-to-one matched pairs (Wilcoxon signed rank test), who were selected on the basis of their propensity scores for receiving LAM. Overall and recurrence-free survival was also compared.
  
  
  RESULTS
  Complete ablation of HCC was achieved in 104 patients with HBV-related HCC between January 2000 and December 2005. LAM was administered to 33 patients after RFA. Serum HBV-DNA became negative by TMA method in 24 (73%) patients. Four patients showed redetection of HBV-DNA with ALT elevation. Subset analysis based on initial Child-Pugh class and paired analysis with matching revealed significant decreases in ALT and bilirubin levels and increases in ALB levels in the first year in the LAM group (DeltaALT = -17, DeltaALB = +0.3, and DeltaTBIL = -0.2) compared with controls (DeltaALT = +5, DeltaALB = +/-0.0, and DeltaTBIL = +0.3). Overall survival and recurrence-free survival did not differ between the two groups. No specific adverse effect was observed in the LAM group.
  
  
  CONCLUSIONS
  LAM after RFA for HBV-related HCC was safe and improved liver function. Further studies are needed to evaluate its effect on survival.
authors: Department of Gastroenterology, University of Tokyo, 7-3-1 Hongo Bunkyo-ku, Tokyo, Japan, 113-8655, yoshidah-2im@h.u-tokyo.ac.jp.
authors: Hideo
authors: H
authors: Yoshida
authors: Haruhiko
authors: H
authors: Yoshida
authors: Eriko
authors: E
authors: Goto
authors: Takahisa
authors: T
authors: Sato
authors: Takamasa
authors: T
authors: Ohki
authors: Ryota
authors: R
authors: Masuzaki
authors: Ryosuke
authors: R
authors: Tateishi
authors: Tadashi
authors: T
authors: Goto
authors: Shuichiro
authors: S
authors: Shiina
authors: Takao
authors: T
authors: Kawabe
authors: Masao
authors: M
authors: Omata