title: [Helicobacter pylori in biopsy specimen of gastric mucosa: frequency and correlation of rapid urease test with histology].
abstract: Between December 1999 and May 2000, general, age and sex distribution of Helicobacter pylori and rapid urease test sensitivity and specificity in correlation with histology were performed on 125 patients after gastroscopy. The average patients' age was 54.98 +/- 15.74, range 20-86 years. There were 71 (57%) of females and 54 (43%) males. Seventy seven (62%) patients were Helicobacter pylori positive on histology, and differences between the sex and age were not statistically different (p = 0.58 and p = 0.07). Sensitivity of the rapid urease test after 30 minutes, 3 and 24 hours was 23, 57 and 81% respectively, specificity was 100, 98 and 94% respectively, positive predictive values were 100, 98 and 95% respectively, and negative predictive values were 45, 59 and 75% respectively. In conclusion, it can be recommended to do biopsy of two specimens, from the antrum and body of the stomach. Distribution of Helicobacter pylori positive is higher in older patients. Rapid urease test has low sensitivity and negative predictive value with high specificity and negative predictive value. The additional advantage can be if the test is positive after 30 minutes, because the therapy can be prescribed immediatelly after the endoscopy.
authors: Klinicka bolnica Split.
authors: Zdravko
authors: Z
authors: Perko
authors: Anto
authors: A
authors: Blazanović
authors: Miroslava
authors: M
authors: Katicić
authors: Zeljko
authors: Z
authors: Mimica
authors: Zoran
authors: Z
authors: Cala
authors: Nikica
authors: N
authors: Druzijanić
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle; D005260:Female; D005753:Gastric Mucosa / Q000382:microbiology* / Q000473:pathology; D016481:Helicobacter Infections / Q000175:diagnosis* / Q000473:pathology; D016480:Helicobacter pylori / Q000302:isolation & purification* / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity; D014510:Urease / Q000032:analysis*; D055815:Young Adult
chemical_list: D014510:Urease