Semiquantitative analysis of surgical biopsies of distinct lung lobes of patients with usual interstitial pneumonia/idiopathic pulmonary fibrosis.
OBJECTIVE
To evaluate the differences between surgical biopsies of distinct lung lobes in terms of the histopathological features of usual interstitial pneumonia, using a semiquantitative score.


METHODS
We selected all of the patients diagnosed with idiopathic pulmonary fibrosis and submitted to surgical biopsy in two distinct lobes between 1995 and 2005 at the Hospital São Paulo and other hospitals operated by the Federal University of São Paulo. In the histological evaluation of the specimens, we used a semiquantitative method based on previous studies, assigning a score to each of the biopsied sites.


RESULTS
In this sample of patients, we found no statistically significant differences that would alter the stage of the disease, based on the score used. This finding was independent of the biopsy site (middle lobe or lingular segment).


CONCLUSIONS
No significant histological differences were found between the lung lobes studied. The definitive histological diagnosis of usual interstitial pneumonia did not alter the stage of the disease.
Gonçalves
José Júlio Saraiva
JJ
Universidade para o Desenvolvimento do Estado e da Região do Pantanal, Campo Grande, MS, Brasil. jjsgon@gmail.com
Leão
Luiz Eduardo Villaça
LE
Ferreira
Rimarcs Gomes
RG
Oliveira
Renato
R
Ota
Luiz Hirotoshi
LH
dos Santos
Ricardo Sales
RS
D000328:Adult; D000368:Aged; D001706:Biopsy / Q000379:methods; D005260:Female; D006801:Humans; D054988:Idiopathic Interstitial Pneumonias / Q000473:pathology*; D054990:Idiopathic Pulmonary Fibrosis / Q000473:pathology; D008168:Lung / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D020775:Thoracic Surgery, Video-Assisted