Serum levels of brain-derived neurotrophic factor in drug-naïve obsessive-compulsive patients: a case-control study.
BACKGROUND
There is lack of data regarding BDNF serum levels in patients with obsessive-compulsive disorder (OCD). The aims of the present study were: 1) to assess the serum BDNF content in a sample of drug-naïve patients with OCD and 2) to assess whether putative alterations in peripheral BDNF may be associated to OCD severity and clinical characteristics.


METHODS
Twenty-four drug-naïve patients with a principal diagnosis of OCD were recruited. In parallel, a control group of 24 unrelated volunteers matched for gender and age was enrolled. Serum BDNF levels were measured by ELISA method.


RESULTS
The results showed that BDNF levels were decreased in OCD patients when compared to controls (36.90+/-6.42 ng/ml versus 41.59+/-7.82 ng/ml; p=0.043). No correlations were evidenced between serum BDNF content and the severity of OCD symptoms measured as Y-BOCS scores or other clinical variables.


CONCLUSIONS
The choice of drug-naïve patients with obsessive-compulsive disorder had limited the size of the sample and excluded the recruitment of patients with a severe symptomatology.


CONCLUSIONS
Our findings reveal for the first time in OCD patients a decrease in serum BDNF levels. These data corroborate the hypothesis of a dysfunction in the neurotrophin expression in the OCD pathogenetic mechanism and provide the rationale for further investigations directed to the identification of novel biomarkers and new therapeutic strategies for antiobsessional treatments.
Maina
Giuseppe
G
Department of Neurosciences, Mood and Anxiety Disorders Unit, University of Turin, Turin, 10126 Torino, Italy. giuseppemaina@hotmail.com
Rosso
Gianluca
G
Zanardini
Roberta
R
Bogetto
Filippo
F
Gennarelli
Massimo
M
Bocchio-Chiavetto
Luisella
L
D000328:Adult; D015415:Biomarkers / Q000097:blood; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood*; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007558:Italy; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000097:blood* / Q000175:diagnosis / Q000523:psychology; D012016:Reference Values
D015415:Biomarkers; D019208:Brain-Derived Neurotrophic Factor