[Effect of angiotensin converting enzyme inhibitors on oxidative stress, endothelial function in patients with myocardial infarction].
We examined 50 patients with acute myocardial infarction (MI) who in dependence on prescription in the content of basic therapy of sulfhydric group containing angiotensin converting enzyme inhibitors (ACEI) zofenopril and captopril were divided into 2 groups each comprizing 25 patients. We studied dynamics of lipid peroxidation, protective antioxidant systems, the state of endothelial function, systemic inflammation, and endogenous cytoprotective mechanisms - the system of nitric oxide (NO) and stress proteins of HSP70 family - during fist 24 hours of hospitalization, in 1 and 6 months after development of MI. We have found that long-term administration of ACEI promotes lowering of free radical oxidation products what is related to activation of protective antioxidant enzymes and total antioxidant activity of blood serum. Preparations also exert positive effect on the state of protective HSP70 system and parameters of endothelial function.
Zdionchenko
V S
VS
Leksina
K S
KS
Timofeeva
N Iu
NIu
Shekhian
G G
GG
Bagatyrova
K M
KM
Mironova
M A
MA
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004730:Endothelium, Vascular / Q000187:drug effects / Q000503:physiopathology*; D005260:Female; D005500:Follow-Up Studies; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000188:drug therapy / Q000503:physiopathology; D018384:Oxidative Stress / Q000187:drug effects*; D013053:Spectrophotometry; D013482:Superoxide Dismutase / Q000097:blood; D013997:Time Factors; D016896:Treatment Outcome
D000806:Angiotensin-Converting Enzyme Inhibitors; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase