title: [Expression pattern of MAL in normal epithelial cells, benign tumor, and squamous cell carcinoma of larynx].
abstract: OBJECTIVE
  To compare the expression pattern of the MAL protein in normal and laryngeal carcinoma to derive possible implications of MAL in carcinoma development of larynx.
  
  
  METHODS
  Use the immunohistochemical technique to analyze the distribution of MAL in normal laryngeal epithelial cells, polyp of vocal cords, laryngeal atypical hyperplasia and laryngeal squamous cell carcinoma.
  
  
  RESULTS
  MAL-like immunohistochemical reactions are strongly expressed in normal laryngeal epithelial cells and its expression is no significantly different in epithelial cells of the polyp of vocal cords. Comparatively, MAL expression is significantly down regulated in laryngeal atypical hyperplasia and laryngeal squamous cell carcinomas (P < 0.05).
  
  
  CONCLUSIONS
  MAL is normally expressed in laryngeal epithelial cells and its expression changes at early stages of carcinoma development. MAL, therefore, is a potential marker for early diagnosis of laryngeal squamous cell carcinoma.
authors: Department of Otorhinolaryngology, Fujian Provincial Hospital, Fuzhou, 350001, China. dr.jiangyi@163.com
authors: Yi
authors: Y
authors: Jiang
authors: Yong
authors: Y
authors: Chen
authors: Lingyun
authors: L
authors: Gao
authors: Qing
authors: Q
authors: Ye
authors: M A
authors: MA
authors: Alonso
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D016022:Case-Control Studies; D004311:Double-Blind Method; D004847:Epithelial Cells / Q000378:metabolism; D006801:Humans; D007820:Laryngeal Mucosa / Q000166:cytology / Q000378:metabolism*; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D026901:Membrane Transport Proteins / Q000378:metabolism*; D009185:Myelin Proteins / Q000378:metabolism*; D062806:Myelin and Lymphocyte-Associated Proteolipid Proteins; D011510:Proteolipids / Q000378:metabolism*
chemical_list: C569026:MAL protein, human; D026901:Membrane Transport Proteins; D009185:Myelin Proteins; D062806:Myelin and Lymphocyte-Associated Proteolipid Proteins; D011510:Proteolipids