title: The molecular signature of endometriosis-associated endometrioid ovarian cancer differs significantly from endometriosis-independent endometrioid ovarian cancer.
abstract: OBJECTIVE
  To determine whether endometriosis-associated endometrioid cancer (EAOC) is a specific entity compared with endometrioid cancer not associated with endometriosis (OC).
  
  
  METHODS
  Case-control study.
  
  
  METHODS
  University hospital research laboratory.
  
  
  METHODS
  Seven patients with endometriosis-associated ovarian cancer EAOC and five patients each with OC, ovarian endometriosis, and benign ovaries.
  
  
  METHODS
  Ovarian tissue samples were collected from surgical procedures.
  
  
  METHODS
  We hybridized cRNA samples to the Affymetrix HG-U133A microarray chip. Representative genes were validated by real time polymerase chain reaction.
  
  
  RESULTS
  We identified two main groups of genes: The first group contained the genes SICA2, CCL14, and TDGF1. These genes were equally regulated in endometriosis and EAOC but not in OC and benign ovaries. The second group contained the genes StAR, SPINT1, Keratin 8, FoxM1B, FOLR1, CRABP1, and Claudin 7. They were equally regulated in EAOC and OC but not in ovarian endometriosis and benign ovaries.
  
  
  CONCLUSIONS
  That the first group is composed of the cytokines SICA2 and CCL14 and the growth factor TDGF1 indicates that the regulation of the autoimmune system and of inflammatory cytokines may be very important in the etiology of endometriosis and EAOC. That the second group is composed of genes that play a central role in cell-cell interaction, differentiation, and cell proliferation indicates that they may be important in the development of ovarian cancer in women with endometriosis.
authors: Department of Gynecology and Obstetrics, University of Schleswig-Holstein, Campus Luebeck, Luebeck, Germany.
authors: Constanze
authors: C
authors: Banz
authors: Laboratory for Functional Genomic Research, Campus Charité Mitte, Berlin, Germany.
authors: Ute
authors: U
authors: Ungethuem
authors: Biochemical Institute, Campus Charité Mitte, Berlin, Germany.
authors: Ralf-Juergen
authors: RJ
authors: Kuban
authors: Department of Gynecology and Obstetrics, University of Schleswig-Holstein, Campus Luebeck, Luebeck, Germany.
authors: Klaus
authors: K
authors: Diedrich
authors: Department of Gynecology and Obstetrics, Section of Gynecologic Oncology, University of Chicago, Chicago, Illinois.
authors: Ernst
authors: E
authors: Lengyel
authors: Department of Gynecology and Obstetrics, University of Schleswig-Holstein, Campus Luebeck, Luebeck, Germany. Electronic address: d.hornung@gmx.de.
authors: Daniela
authors: D
authors: Hornung
mesh_terms: D000328:Adult; D000368:Aged; D018269:Carcinoma, Endometrioid / Q000209:etiology / Q000235:genetics*; D016022:Case-Control Studies; D004715:Endometriosis / Q000150:complications / Q000235:genetics*; D005260:Female; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008875:Middle Aged; D020411:Oligonucleotide Array Sequence Analysis; D010049:Ovarian Diseases / Q000150:complications / Q000235:genetics*; D010051:Ovarian Neoplasms / Q000209:etiology / Q000235:genetics*