Femoral osteomyelitis due to Cladophialophora arxii in a patient with chronic granulomatous disease.
Fungal infections in patients with chronic granulomatous disease (CGD) are a poor prognostic factor. We describe the first case of CGD with femoral osteomyelitis due to Cladophialophora arxii, which is a member of the dematiaceous group. The causative fungus was identified on the basis of its morphological characteristics, growth temperature profile, and nucleotide sequence on the internal transcribed space region of the ribosomal gene. The patient was successfully treated with surgical debridement, subsequent administration of itraconazolem and interferon-gamma.
Shigemura
T
T
Dept. of Pediatrics, Shinshu University School of Medicine, Nagano, 390-8621, Japan. tomonari@shinshu-u.ac.jp
Agematsu
K
K
Yamazaki
T
T
Eriko
K
K
Yasuda
G
G
Nishimura
K
K
Koike
K
K
D000935:Antifungal Agents / Q000627:therapeutic use; D001203:Ascomycota / Q000166:cytology / Q000235:genetics / Q000302:isolation & purification* / Q000502:physiology; D004271:DNA, Fungal / Q000737:chemistry / Q000235:genetics; D021903:DNA, Ribosomal Spacer / Q000737:chemistry / Q000235:genetics; D003646:Debridement; D005269:Femur / Q000473:pathology*; D006105:Granulomatous Disease, Chronic / Q000150:complications*; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use; D007371:Interferon-gamma / Q000627:therapeutic use; D017964:Itraconazole / Q000627:therapeutic use; D008297:Male; D009181:Mycoses / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology / Q000601:surgery; D010019:Osteomyelitis / Q000188:drug therapy / Q000382:microbiology* / Q000601:surgery; D017422:Sequence Analysis, DNA; D055815:Young Adult
D000935:Antifungal Agents; D004271:DNA, Fungal; D021903:DNA, Ribosomal Spacer; D007155:Immunologic Factors; D017964:Itraconazole; D007371:Interferon-gamma