title: Vertebrobasilar junction fenestration with dumbbell-shaped aneurysms formation: computational fluid dynamics analysis.
abstract: BACKGROUND
  We report 8 rare cases of paired ANs involving fenestrated vertebrobasilar junction and demonstrate the flow patterns of the paired ANs by qualitative CFD analysis in 5 cases.
  
  
  METHODS
  Two-dimensional and 3-dimensional angiographic features of 8 cases were reviewed. Nine patient-specific geometries of CFD models in 5 cases were created for flow analysis.
  
  
  RESULTS
  All 8 cases had 2 ANs, one large and the other small, projecting to the opposite sides at the proximal end of fenestrated vertebrobasilar junction. The different angiographic findings between right VA and left VA suggested the different hemodynamic characteristics of the respective VAs. Computational fluid dynamics analysis also demonstrated that the inflows of these paired ANs were different between right VA and left VA. Flow simulations by CFD were consistent with angiographic findings.
  
  
  CONCLUSIONS
  Intrinsic wall defects at fenestrated vertebrobasilar junction and specific hemodynamic stresses from 2 inflows may contribute to the formation of a pair of dumbbell-shaped ANs.
authors: Department of Neuroendovascular Therapy, Tohoku University, Japan. astrocytoma2001@yahoo.com.tw
authors: Yuang-Seng
authors: YS
authors: Tsuei
authors: Yasushi
authors: Y
authors: Matsumoto
authors: Makoto
authors: M
authors: Ohta
authors: Toshio
authors: T
authors: Nakayama
authors: Masayuki
authors: M
authors: Ezura
authors: Akira
authors: A
authors: Takahashi
mesh_terms: D000328:Adult; D000368:Aged; D015901:Angiography, Digital Subtraction / Q000379:methods; D001488:Basilar Artery / Q000002:abnormalities* / Q000000981:diagnostic imaging / Q000473:pathology; D001807:Blood Vessel Prosthesis; D002560:Cerebrovascular Circulation / Q000502:physiology*; D003198:Computer Simulation; D004621:Embolization, Therapeutic / Q000295:instrumentation / Q000379:methods; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods; D002532:Intracranial Aneurysm / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D019635:Neurosurgical Procedures / Q000295:instrumentation / Q000379:methods; D011300:Preoperative Care; D012189:Retrospective Studies; D012984:Software; D014711:Vertebral Artery / Q000002:abnormalities* / Q000000981:diagnostic imaging / Q000473:pathology; D020217:Vertebral Artery Dissection / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology*; D014715:Vertebrobasilar Insufficiency / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology*