The management of severe sepsis and septic shock.
The diagnosis and management of severe sepsis and septic shock is a complex and dynamic process. Newer evidence-based interventions are constantly being developed and implemented with the purpose of improving morbidity and mortality. Current investigations are being performed in hospital environments to determine the change in behaviors and clinical impact with the most recent recommendations. The use of standardized treatment protocols in addition to newer diagnostic and treatment modalities in patients who have severe sepsis and septic shock can continue to improve patient-related outcomes and the damaging effect of these diseases on society.
Morrell
Matthew R
MR
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, Barnes-Jewish Hospital, 660 South Euclid Avenue, Campus Box 8052, St. Louis, MO 63110, USA. mmorrell@dom.wustl.edu
Micek
Scott T
ST
Kollef
Marin H
MH
D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D002405:Catheterization, Central Venous; D016638:Critical Illness; D006801:Humans; D017410:Practice Guidelines as Topic; D012121:Respiration, Artificial; D018805:Sepsis / Q000628:therapy*; D012772:Shock, Septic / Q000628:therapy*; D014662:Vasoconstrictor Agents / Q000627:therapeutic use*
D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D014662:Vasoconstrictor Agents