Influence of dexamethasone on the expression levels of P-selectin protein in multiple organs of rats with severe acute pancreatitis.
OBJECTIVE
To investigate the effect of dexamethasone on the expression levels of P-selectin protein in multiple organs of rats with severe acute pancreatitis (SAP).


METHODS
Rats were randomly divided into sham-operated, model control, and dexamethasone-treated groups. At 3, 6, and 12 h after operation, the expression levels of P-selectin protein in one-third of the rats in each group were observed.


RESULTS
In the treated group, the expression levels of P-selectin protein in the pancreas head (at 6 h), lung (at 12 h), liver (at 3 h), and spleen (at 6 and 12 h) were significantly lower than those in the model control group (P < 0.05). Additionally, the products of the staining intensity and positive rate of P-selectin protein in liver (at 3 h), lung (at 6 and 12 h), and spleen (at 12 h) in the treated group were significantly lower than those in the model control group (P < 0.05).


CONCLUSIONS
Dexamethasone can inhibit P-selectin protein expression in multiple organs of SAP rats.
Xiping
Zhang
Z
Department of General Surgery, Hangzhou First People's Hospital, Zhejiang, China. zxp99688@vip.163.com
Jun
Fu
F
Jie
Zhang
Z
Bingyan
Yu
Y
Jing
Ma
M
Wei
Zhu
Z
Jing
Ye
Y
Penghui
Jia
J
Wenqin
Yuan
Y
Ninnin
Zhou
Z
Jiao
He
H
D000208:Acute Disease; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D003907:Dexamethasone / Q000627:therapeutic use*; D004195:Disease Models, Animal; D007668:Kidney / Q000378:metabolism / Q000473:pathology; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008168:Lung / Q000378:metabolism / Q000473:pathology; D008297:Male; D019007:P-Selectin / Q000378:metabolism*; D010179:Pancreas / Q000378:metabolism / Q000473:pathology; D010195:Pancreatitis / Q000188:drug therapy* / Q000378:metabolism* / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012720:Severity of Illness Index; D013154:Spleen / Q000378:metabolism / Q000473:pathology
D000893:Anti-Inflammatory Agents; D019007:P-Selectin; D003907:Dexamethasone