title: Ordered nanoclusters in lipid-cholesterol membranes.
abstract: X-ray diffraction of sphingomyelin-dihydrocholesterol (SM-DChol) monolayers revealed short-ranged ( approximately 25 A) 2D ordering. These nanoclusters show two distinct regions: below the cusp point of the phase diagram (35 mol% DChol), a constant d spacing was observed; above the cusp, the d spacing increases linearly with DChol in accordance to Vegard's law for binary alloys. The components in this lipidic alloy are thus a 65ratio35 SM-DChol entity and excess DChol. Reflectivity data further support the emergence above the cusp of an uncomplexed DChol population with greater vertical mobility.
authors: Department of Physics, Institute for Biophysical Dynamics, and The James Franck Institute, The University of Chicago, 929 E. 57th Street, Chicago, Illinois 60637, USA.
authors: Maria K
authors: MK
authors: Ratajczak
authors: Eva Y
authors: EY
authors: Chi
authors: Shelli L
authors: SL
authors: Frey
authors: Kathleen D
authors: KD
authors: Cao
authors: Laura M
authors: LM
authors: Luther
authors: Ka Yee C
authors: KY
authors: Lee
authors: Jaroslaw
authors: J
authors: Majewski
authors: Kristian
authors: K
authors: Kjaer
mesh_terms: D004083:Cholestanol / Q000737:chemistry*; D008560:Membrane Fluidity; D008567:Membranes, Artificial; D049329:Nanostructures / Q000737:chemistry*; D013109:Sphingomyelins / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D008567:Membranes, Artificial; D013109:Sphingomyelins; D004083:Cholestanol