[Activity of Ertapenem and Ceftriaxone in the eradication of Salmonella in a model of experimental peritonitis in mice].
Since the beginning of the 1990s, the prevalence of isolates of non-typhoidal Salmonella species resistant to antimicrobial agents, including those commonly used for the treatment of Salmonella infections such as fluoroquinolones, trimethoprim-sulfamethoxazole or beta-lactams, has increased substantially. Infections caused by multidrug-resistant strains of non-typhoidal Salmonella are now frequently encountered. In order to consider an appropriate role of Ertapenem in Salmonella-due intraabdominal infections, in the present study we compare the efficacy of Ertapenem versus that of Ceftriaxone in a mouse peritonitis model. Bacteriological eradication from blood, liver and mesenteric lymph nodes was observed after 5 and 7 days of treatment in all infected mice receiving ceftriaxone. Although both antimicrobial agents -Ertapenem and Ceftriaxone- were observed to be effective in reducing mortality in inoculated mice, our data suggests a reduced efficacy of Ertapenem in the bacteriological eradication of Salmonella enterica serotype Typhimurium in a mouse peritonitis model.
Lozano
F S
FS
Facultad de Medicina - Departamento de Cirugía, Universidad de Salamanca, Avda. Alfonso X El Sabio, s/n37007 Salamanca (España). lozano@usal.es
García
M I
MI
García
E
E
González
B
B
García
M B
MB
García
F J
FJ
García
J E
JE
D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002443:Ceftriaxone / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D000077727:Ertapenem; D008297:Male; D051379:Mice; D010538:Peritonitis / Q000188:drug therapy* / Q000382:microbiology / Q000401:mortality; D012480:Salmonella Infections / Q000188:drug therapy* / Q000382:microbiology / Q000401:mortality; D019779:Salmonella enterica / Q000187:drug effects; D047090:beta-Lactams / Q000627:therapeutic use*
D000900:Anti-Bacterial Agents; D047090:beta-Lactams; D002443:Ceftriaxone; D000077727:Ertapenem