The development of the MCH system.
Although a great deal is published on the MCH neurons, very few works were devoted to the study of their development. However, existing literature points out two important traits: first, these neurons differentiate a MCH phenotype very early in all species studied so far, which might suggest a role for the MCH peptide during development; second, in the rat, birth date greatly influence the phenotype of MCH neurons. At least two sub-populations were described on the basis of their chemical phenotype, projection pattern and birth date. The understanding of processes involved in the differentiation of these sub-populations may help understand the medio-lateral differentiation of the tuberal hypothalamus.
Risold
P Y
PY
Université de Franche-Comté, Besançon, France. pierre-yves.risold@univ-fcomte.fr
Croizier
S
S
Legagneux
K
K
Brischoux
F
F
Fellmann
D
D
Griffond
B
B
D000818:Animals; D002454:Cell Differentiation / Q000235:genetics / Q000502:physiology; D006801:Humans; D007028:Hypothalamic Hormones / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D008543:Melanins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D009474:Neurons / Q000166:cytology / Q000378:metabolism*; D010907:Pituitary Hormones / Q000235:genetics / Q000378:metabolism / Q000502:physiology*
D007028:Hypothalamic Hormones; D008543:Melanins; D010907:Pituitary Hormones; C019463:melanin-concentrating hormone