title: Carcinoma within solitary ductal papilloma of the breast.
abstract: BACKGROUND
  Solitary ductal papilloma of the breast, traditionally considered a benign disorder, was recently found to have malignant potential, especially when associated with atypical ductal hyperplasia.
  
  
  METHODS
  All patients diagnosed with solitary ductal papilloma at a tertiary medical center from 1994 to 2004 were identified by a database search. Background, clinical and pathological data were collected for those with a carcinoma within the papilloma, and their pathological specimens were revised.
  
  
  RESULTS
  Of the 3849 breast biopsies performed in our medical center during the study period, 77 (2%) yielded a solitary ductal papilloma. In 12 cases (15.6% of all solitary ductal papillomas; 0.3% of all breast biopsies), a carcinoma was found within the papilloma. Ten were diagnosed as carcinoma in situ and 2 as microinvasive carcinoma.
  
  
  CONCLUSIONS
  In the present series, the incidence of carcinoma within solitary ductal papilloma was 15.6%, indicating that solitary ductal papillomas have malignant potential.
  
  
  CONCLUSIONS
  Carcinoma within solitary ductal papilloma of the breast was found in 15.6% of all papillomas. This seems to indicate a malignant potential of papillomas and the need for surgical excision.
authors: Departments of Surgery A&B, Rabin Medical Center, Beilinson Campus, Petach Tikva and Sackler School of Medicine, Tel Aviv University, Tel Aviv 49100, Israel. fgreif@clalit.org.il
authors: F
authors: F
authors: Greif
authors: E
authors: E
authors: Sharon
authors: I
authors: I
authors: Shechtman
authors: S
authors: S
authors: Morgenstern
authors: H
authors: H
authors: Gutman
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D001943:Breast Neoplasms / Q000453:epidemiology / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D002278:Carcinoma in Situ / Q000453:epidemiology / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D018270:Carcinoma, Ductal, Breast / Q000453:epidemiology / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007557:Israel / Q000453:epidemiology; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000473:pathology; D018300:Papilloma, Intraductal / Q000453:epidemiology / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D012307:Risk Factors; D016896:Treatment Outcome