Molecular aspects of ischaemic postconditioning.
Preconditioning, a well established phenomenon had been used since 1980s to attenuate ischaemia-reperfusion induced injury. However, inability to predict the onset of ischaemia in clinical settings led to the discovery of a new concept of postconditioning (PoCo), in 2000s whereby brief repetitive cycles of ischaemia with intermittent reperfusion followed by prolonged ischaemia-elicited tissue protection. There is an impressive array of molecular mechanisms contributing to PoCo-mediated tissue-protection, which include triggers like adenosine (ADO), opioid, erythropoietin (EPO), endogenous nitric-oxide, reactive oxygen species, acetylcholine, tissue factors, pro-inflammatory cytokines and bradykinin; mediators like reperfusion injury salvage kinase pathways including phosphoinositide-3-kinase, extra-cellular signal regulated kinase(1/2) pathway, protein kinase G and protein kinase C; end-effectors like mitochondrial permeability transition pore and mitochondrial potassium ATP channel. The clinical applicability of PoCo has been extended with the use of PoCo mimetic agents like insulin, glucagon like peptide, EPO, statins and ADO before reperfusion in patients with ischaemia reperfusion injury. Remote PoCo has also emerged as a new concept; however, considerable research is required for understanding its molecular mechanisms. In this review, an exhaustive attempt has been made to unearth some molecular aspects of PoCo.
Kaur
Shaminder
S
Department of Pharmaceutical Sciences & Drug Research, Punjabi University, Patiala, Punjab, India.
Jaggi
Amteshwar Singh
AS
Singh
Nirmal
N
D000818:Animals; D006801:Humans; D019194:Ischemic Preconditioning; D015425:Myocardial Reperfusion / Q000379:methods; D015428:Myocardial Reperfusion Injury / Q000201:enzymology / Q000276:immunology / Q000378:metabolism / Q000517:prevention & control; D015424:Reperfusion / Q000379:methods*; D015427:Reperfusion Injury / Q000201:enzymology / Q000276:immunology / Q000378:metabolism / Q000517:prevention & control*; D013997:Time Factors