title: Anti-oxidant, anti-fungal and anti-leishmanial activities of novel 3-[4-(1H-imidazol-1-yl) phenyl]prop-2-en-1-ones.
abstract: A series of new 3-[4-(1H-imidazol-1-yl) phenyl]prop-2-en-1-ones were synthesized by the condensation of various acetophenones with 4-(1H-imidazol-1-yl) benzaldehyde which was itself prepared by the N-arylation of imidazole using hexadecyltrimethylammonium bromide as catalyst for the first time. All the synthesized compounds were subjected to preliminary evaluation for their anti-leishmanial, anti-oxidant and anti-fungal activities. Few of the synthesized compounds showed significant activities.
authors: Institute of Chemistry, University of the Punjab, Lahore 54590, Pakistan.
authors: Tanvir
authors: T
authors: Hussain
authors: Hamid Latif
authors: HL
authors: Siddiqui
authors: Muhammad
authors: M
authors: Zia-ur-Rehman
authors: Muhammad
authors: M
authors: Masoom Yasinzai
authors: Masood
authors: M
authors: Parvez
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D000977:Antiparasitic Agents / Q000737:chemistry / Q000494:pharmacology*; D047188:Chalcones / Q000737:chemistry / Q000494:pharmacology; D018360:Crystallography, X-Ray; D005658:Fungi / Q000187:drug effects; D007093:Imidazoles / Q000737:chemistry / Q000494:pharmacology*; D007891:Leishmania / Q000187:drug effects*; D007896:Leishmaniasis / Q000188:drug therapy; D008958:Models, Molecular
chemical_list: D000935:Antifungal Agents; D000975:Antioxidants; D000977:Antiparasitic Agents; D047188:Chalcones; D007093:Imidazoles; C029899:imidazole