Recent developments and applications of polymer-supported reagents in synthetic organic chemistry.
The demand for large numbers of compounds of pharmaceutical and agricultural interest has led to the development of sophisticated methods for the preparation of compound libraries on solid support. To circumvent the inherent difficulties associated with the inability to monitor the reaction of the immobilized substrates by rapid and analytical techniques (TLC, GC, HPLC and NMR), much effort has been directed towards the development of parallel solution-phase synthesis. Here, the reagents and sequestering agents are attached to a polymer support, so as to facilitate product purification by filtration of these materials. This review describes the latest developments of polymer-supported reagents and their applications.
Brümmer
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The Scripps Research Institute, Department of Chemistry, La Jolla, CA 92037, USA.
Clapham
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Janda
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