title: Role of selection and inbreeding on the incidence of cutaneous malignant melanoma in Sinclair swine.
abstract: This paper reports the quantitative analysis of the historical database of a herd of Sinclair swine affected by cutaneous malignant melanoma. The herd was under partial and non-systematic selection for melanoma susceptibility (animals having at least one tumour during the first 6 weeks of life). Weighted selection differentials for the number of tumours at birth and the number of tumours at 6 weeks were generally positive and between -0.43 and 4.76 tumours for the number of tumours at 6 weeks. Estimates of the heritability for number of tumours at birth and at 6 weeks using 1934 animals were 0.27 (+/-0.03) and 0.25 (+/-0.03), respectively. The estimate of the genetic correlation between these two traits was 0.95 (+/-0.03). Genetic trends were positive for the number of tumours at birth and at 6 weeks. In spite of positive selection differentials and a moderate heritability, there was a negative phenotypic trend in the number of tumours. Natural selection might be acting in a direction opposite to artificial selection in the Sinclair herd. The slopes of the regression of the number of tumours at birth, at 6 weeks, and melanoma susceptibility on individual inbreeding coefficients were non-significant, indicating no evidence of dominance. The number of live-born pigs was lower in litters from parents susceptible to the disease (p < 0.01).
authors: Department of Animal Biotechnology, University of Nevada, Reno, Reno, NV 89557, USA. lgomezraya@cabnr.unr.edu
authors: L
authors: L
authors: Gomez-Raya
authors: M S
authors: MS
authors: Amoss
authors: Y
authors: Y
authors: Da
authors: C W
authors: CW
authors: Beattie
authors: O
authors: O
authors: Ash
authors: W M
authors: WM
authors: Rauw
mesh_terms: D000818:Animals; D016208:Databases, Factual; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007178:Inbreeding; D008297:Male; D008545:Melanoma / Q000235:genetics*; D036801:Parturition; D010641:Phenotype; D012641:Selection, Genetic; D012878:Skin Neoplasms / Q000235:genetics*; D034421:Sus scrofa / Q000235:genetics*