title: [Study on dissolution in vitro of Zhike Pingchuan sustained-release tablets].
abstract: OBJECTIVE
  To establish a method to evaluate the in vitro release of Zhike Pingchuan sustained-release tablets.
  
  
  METHODS
  The ephedrine, pseudoephedrine, scopolamine were chosen as marker components components, and the chromatographic conditions were chosen according to the separation of baseline and theoretical plate number for determining the marker in vitro release of Zhike Pingchuan sustained-release tablets; through the dissolution curves of the three active components, the release behavior was judged as well-balanced release or not.
  
  
  RESULTS
  Compared with conventional tablets, the Zhike Pingchuan sustained-release tablets had a well-balanced behavior in 10 h.
  
  
  CONCLUSIONS
  The maker components of Zhike Pingchuan sustained-release tablets and two chromatographic conditions, which were used to determine the dissolution of the sustained-release tablets, could be chosen as evaluation methods for the in vitro release of Zhike Pingchuan sustained-release tablets.
authors: Research & Development Institute of Chinese Materia Medica of Guangdong Pharmaceutical University, Guangzhou 510006, China.
authors: Xiaoyan
authors: X
authors: Li
authors: Zhong
authors: Z
authors: Feng
authors: Wuzhen
authors: W
authors: Huo
authors: Yuanxin
authors: Y
authors: Li
authors: Bo
authors: B
authors: Wang
authors: Shengshan
authors: S
authors: Zhu
mesh_terms: D000284:Administration, Oral; D002626:Chemistry, Pharmaceutical; D002851:Chromatography, High Pressure Liquid; D003692:Delayed-Action Preparations / Q000737:chemistry*; D004337:Drug Carriers; D004339:Drug Compounding; D004355:Drug Stability; D004809:Ephedrine / Q000737:chemistry; D006244:Hardness; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet; D013607:Tablets / Q000737:chemistry
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004364:Pharmaceutical Preparations; D013607:Tablets; D004809:Ephedrine