title: Internal friction and nonequilibrium unfolding of polymeric globules.
abstract: The stretching response of a single collapsed homopolymer is studied using Brownian dynamic simulations. The irreversibly dissipated work is found to be dominated by internal friction effects below the collapse temperature, and the internal viscosity grows exponentially with the effective cohesive strength between monomers. These results explain friction effects of globular DNA and are relevant for dissipation at intermediate stages of protein folding.
authors: Department of Materials Science and Engineering, MIT, Cambridge, Massachusetts 02139, USA.
authors: Alfredo
authors: A
authors: Alexander-Katz
authors: Hirofumi
authors: H
authors: Wada
authors: Roland R
authors: RR
authors: Netz
mesh_terms: D010582:Bacteriophage lambda / Q000235:genetics; D004279:DNA, Viral / Q000737:chemistry; D008956:Models, Chemical; D008968:Molecular Conformation; D009690:Nucleic Acid Conformation; D011108:Polymers / Q000737:chemistry*; D017510:Protein Folding; D011506:Proteins / Q000737:chemistry; D013269:Stochastic Processes; D013816:Thermodynamics; D014783:Viscosity
chemical_list: D004279:DNA, Viral; D011108:Polymers; D011506:Proteins