title: Oleanane-type triterpene oligoglycosides with pancreatic lipase inhibitory activity from the pericarps of Sapindus rarak.
abstract: The methanolic extract from the pericarps of Sapindus rarak DC. was found to show pancreatic lipase inhibitory activity (IC50=ca. 614 microg/mL). From the extract, oleanane-type triterpene oligoglycosides, rarasaponins I-III (1-3), and raraoside A (4), were isolated together with 13 known saponins and four known sesquiterpene glycosides. Among them, several saponin constituents including rarasaponins I (1, IC50=131microM) and II (2, 172microM), and raraoside A (4, 151microM) inhibited pancreatic lipase activity, which were stronger than that of theasaponin E(1) (270microM).
authors: Pharmaceutical Research and Technology Institute, Kinki University, 3-4-1 Kowakae, Higashi-Osaka, Osaka 577-8502, Japan.
authors: Toshio
authors: T
authors: Morikawa
authors: Pharmaceutical Research and Technology Institute, Kinki University, 3-4-1 Kowakae, Higashi-Osaka, Osaka 577-8502, Japan; School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Wenhua Rd., Shenyang 110016, People's Republic of China.
authors: Yuanyuan
authors: Y
authors: Xie
authors: Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8412, Japan.
authors: Yasunobu
authors: Y
authors: Asao
authors: Pharmaceutical Research and Technology Institute, Kinki University, 3-4-1 Kowakae, Higashi-Osaka, Osaka 577-8502, Japan.
authors: Masaki
authors: M
authors: Okamoto
authors: Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8412, Japan.
authors: Chihiro
authors: C
authors: Yamashita
authors: Pharmaceutical Research and Technology Institute, Kinki University, 3-4-1 Kowakae, Higashi-Osaka, Osaka 577-8502, Japan.
authors: Osamu
authors: O
authors: Muraoka
authors: Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8412, Japan.
authors: Hisashi
authors: H
authors: Matsuda
authors: Faculty of Science and Technology, Rajamangala University of Technology, Srivijaya, Thungyai, Nakhonsithammarat 80240, Thailand.
authors: Yutana
authors: Y
authors: Pongpiriyadacha
authors: School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Wenhua Rd., Shenyang 110016, People's Republic of China.
authors: Dan
authors: D
authors: Yuan
authors: Pharmaceutical Research and Technology Institute, Kinki University, 3-4-1 Kowakae, Higashi-Osaka, Osaka 577-8502, Japan; Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8412, Japan. Electronic address: myoshika@mb.kyoto-phu.ac.jp.
authors: Masayuki
authors: M
authors: Yoshikawa
mesh_terms: D000818:Animals; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D008049:Lipase / Q000037:antagonists & inhibitors*; D015394:Molecular Structure; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D010179:Pancreas / Q000201:enzymology*; D010946:Plants, Medicinal / Q000737:chemistry*; D032127:Sapindus / Q000737:chemistry*; D012503:Saponins / Q000494:pharmacology; D013552:Swine
chemical_list: D006027:Glycosides; D012503:Saponins; C543014:raraoside A; C543013:rarasaponin I; C117120:theasaponin E1; D009828:Oleanolic Acid; D008049:Lipase