title: Study of analgesic and anti-inflammatory effects of lappaconitine gelata.
abstract: OBJECTIVE
  To explore the analgesic and anti-inflammatory effects of lappaconitine gelata (LA).
  
  
  METHODS
  The writhing response induced by acetic acid, the pain response induced by formaldehyde and hot plate method in the mouse, and the paw edema induced by egg albumen in the rat and the ear edema induced by xylene in the mouse were used for investigation on the analgesic and anti-inflammatory effects of LA.
  
  
  RESULTS
  The writhing response induced by acetic acid, the pain response induced by formaldehyde and hot plate methods was significantly inhibited by LA. In addition, the paw edema induced by egg albumen in the rat and the ear edema induced by xylene in the mouse were all significantly suppressed by LA.
  
  
  CONCLUSIONS
  LA has the analgesic and anti-inflammatory effects.
authors: College of Chinese Materia Medica, Beijing University of Traditional Chinese Medicine, Beijing 100102, China.
authors: Ying-zi
authors: YZ
authors: Wang
authors: Yong-qing
authors: YQ
authors: Xiao
authors: Chao
authors: C
authors: Zhang
authors: Xiu-mei
authors: XM
authors: Sun
mesh_terms: D000157:Aconitine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000700:Analgesics / Q000627:therapeutic use*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D051379:Mice; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D004365:Drugs, Chinese Herbal; D000157:Aconitine; C022150:lappaconitine