A combination of curcumin and ginger extract improves abrasion wound healing in corticosteroid-impaired hairless rat skin.
Hairless rats were topically treated with a combination of 10% curcumin and 3% ginger extract (or with each agent alone) for a 21-day period. Following this, the rats were treated topically with Temovate (corticosteroid) for an additional 15 days. At the end of the treatment period, superficial abrasion wounds were induced in the treated skin. Abrasion wounds healed more slowly in the skin of Temovate-treated rats than in skin of control animals. Healing was more rapid in skin of rats that had been pretreated with either curcumin or ginger extract alone or with the combination of curcumin-ginger extract (along with Temovate) than in the skin of rats treated with Temovate and vehicle alone. Skin samples were obtained at the time of wound closure. Collagen production was increased and matrix metalloproteinase-9 production was decreased in the recently healed skin from rats treated with the botanical preparation relative to rats treated with Temovate plus vehicle. In none of the rats was there any indication of skin irritation during the treatment phase or during wounding and repair. Taken together, these data suggest that a combination of curcumin and ginger extract might provide a novel approach to improving structure and function in skin and, concomitantly, reducing formation of nonhealing wounds in "at-risk" skin.
Bhagavathula
Narasimharao
N
Department of Pathology, The University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
Warner
Roscoe L
RL
DaSilva
Marissa
M
McClintock
Shannon D
SD
Barron
Adam
A
Aslam
Muhammad N
MN
Johnson
Kent J
KJ
Varani
James
J
D000287:Administration, Topical; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage; D003474:Curcumin / Q000008:administration & dosage*; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination; D020939:Zingiber officinale; D005938:Glucocorticoids / Q000494:pharmacology*; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage*; D051381:Rats; D054772:Rats, Hairless; D012867:Skin / Q000187:drug effects / Q000293:injuries* / Q000473:pathology; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects*; D014947:Wounds and Injuries / Q000188:drug therapy* / Q000473:pathology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D005938:Glucocorticoids; D010936:Plant Extracts; D003474:Curcumin