[The influence of palladium containing new synthesized biological active substances to protein metabolism in organism].
The aim of the research was to study new drugs with palladium developed and synthesized at the Azerbaijan Medical University Scientific-Research Center Two compounds of palladium-4-aminopyridin ammonium tetrachlor palladium and Bi 4-aminopyridin dichlor were studied as more perspective substances which decrease growth of tumor. Water solution of 0.5% of these compounds were administrated intraperitoneally during 6 sessions. There were noticeable changes in protein metabolism, particularly in alpha(1) and alpha(2) fraction. The drug toxicity (Nedoshvina method), maximal endurance (LD(0)), medium lethal dose (LD(50)), lethal dose (LD(100)), cytogenetic activity (Rappoport method) were studied.
Polukhova
Sh M
ShM
Ganiev
M M
MM
Garaev
G Sh
GSh
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D001798:Blood Proteins / Q000032:analysis / Q000378:metabolism*; D009942:Organometallic Compounds / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D011817:Rabbits
C546491:4-aminopyridin ammonium tetrachlor palladium; D000970:Antineoplastic Agents; D001798:Blood Proteins; D009942:Organometallic Compounds; C546492:bi 4-aminopyridin dichlor palladium