title: Mesial temporal sclerosis after posterior reversible encephalopathy syndrome.
abstract: Neither intrathecal methotrexate nor posterior reversible encephalopathy syndrome has previously been reported to result in mesial temporal sclerosis. Described here is the case of a boy with no risk factors for mesial temporal sclerosis who presented with posterior reversible encephalopathy syndrome and partial complex seizures 8 days after initiation of intrathecal methotrexate for treatment of Burkitt lymphoma, and who ultimately progressed to intractable temporal lobe epilepsy due to left mesial temporal sclerosis.
authors: Mayo Medical School, Rochester, Minnesota, USA.
authors: Mariam S
authors: MS
authors: Aboian
authors: Mithri R
authors: MR
authors: Junna
authors: Karl N
authors: KN
authors: Krecke
authors: Elaine C
authors: EC
authors: Wirrell
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use; D001927:Brain Diseases / Q000209:etiology* / Q000473:pathology; D002051:Burkitt Lymphoma / Q000188:drug therapy / Q000473:pathology; D002648:Child; D038524:Diffusion Magnetic Resonance Imaging; D004833:Epilepsy, Temporal Lobe / Q000209:etiology / Q000473:pathology; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008727:Methotrexate / Q000009:adverse effects / Q000627:therapeutic use; D012307:Risk Factors; D012598:Sclerosis; D012640:Seizures / Q000209:etiology / Q000473:pathology; D013577:Syndrome; D013702:Temporal Lobe / Q000187:drug effects / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents; D008727:Methotrexate