Common genetic coagulation variants are not associated with ischemic stroke in a case-control study.
OBJECTIVE
Abnormalities in the coagulation pathway are often included in the diagnostic work-up of stroke patients, especially in young adults with cryptogenic stroke.


METHODS
Three common genetic variants within the coagulation cascade were investigated in 500 control subjects and in 167 patients with ischemic stroke defined by TOAST subclassification. Analysed variants were factor V Leiden, prothrombin 20210G-->A and factor XIII Val34Leu.


RESULTS
The factor V Leiden mutation was over-represented in patients with cardioembolic stroke for trend, whereas the prothrombin 20210G-->A variant and the factor XIII polymorphism Val34Leu were not associated with stroke of any subtype. The three polymorphisms showed no association with stroke in subgroups of patients defined by age (<40, 40-49, 50-59, > or =60 years).


CONCLUSIONS
This study suggests that the analysis of prothrombin 20210G-->A and factor XIII Val34Leu is not a useful diagnostic procedure in the work-up of ischemic stroke.
Moskau
Susanna
S
Department of Neurology, University of Bonn, Sigmund-Freud-Strasse 25, 53105 Bonn, Germany.
Smolka
Kerstin
K
Semmler
Alexander
A
Schweichel
Dirk
D
Harbrecht
Ursula
U
Müller
Jens
J
Pohl
Christoph
C
Klockgether
Thomas
T
Linnebank
Michael
M
D000328:Adult; D000367:Age Factors; D001777:Blood Coagulation / Q000235:genetics / Q000502:physiology; D002545:Brain Ischemia / Q000235:genetics*; D016022:Case-Control Studies; D005165:Factor V / Q000235:genetics* / Q000378:metabolism; D005176:Factor XIII / Q000235:genetics* / Q000378:metabolism; D005260:Female; D056726:Genetic Association Studies; D014644:Genetic Variation; D005858:Germany; D006801:Humans; D020766:Intracranial Embolism / Q000235:genetics; D008297:Male; D008875:Middle Aged; D008955:Models, Cardiovascular; D011110:Polymorphism, Genetic; D011516:Prothrombin / Q000235:genetics* / Q000378:metabolism; D020521:Stroke / Q000235:genetics*; D044465:White People / Q000235:genetics
C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin; D005176:Factor XIII