title: UV-Vis spectrophotometrical and analytical methodology for the determination of singlet oxygen in new antibacterials drugs.
abstract: We have determined and quantified spectrophotometrically the capacity of producing reactive oxygen species (ROS) as (1)O(2) during the photolysis with UV-A light of 5 new synthesized naphthyl ester derivates of well-known quinolone antibacterials (nalidixic acid (1), cinoxacin (2), norfloxacin (3), ciprofloxacin (4) and enoxacin (5)). The ability of the naphthyl ester derivatives (6-10) to generate singlet oxygen were detecting and for the first time quantified by the histidine assay, a sensitive, fast and inexpensive method. The following tendency of generation of singlet oxygen was observed: compounds 7 > 10 > 6 > 8 > 9 >> parent drugs 1-5.
authors: Laboratorio de Fotoquímica, Centro de Química, Instituto Venezolano de Investigaciones Científicas, Apartado 21827, Caracas 1020-A, Venezuela.
authors: Tamara
authors: T
authors: Zoltan
authors: Franklin
authors: F
authors: Vargas
authors: Carla
authors: C
authors: Izzo