No association of alcohol dependence with SLC6A5 and SLC6A9 glycine transporter polymorphisms.
To determine whether glycine transporter polymorphisms are associated with alcoholism, three genetic variants of SLC6A5 and two polymorphisms of SLC6A9 were genotyped in 463 German non-alcoholic controls and 644 German alcohol-dependent subjects. Association was investigated employing chi-square statistics and haplotype analysis. There was a significant association between the SLC6A5 polymorphism (rs1443547) and alcohol dependence as alcoholic individuals had a lower rate of AG-allele (chi(2) = 6.048, P = 0.049, d.f. = 2), which did not remain significant after correction for multiple testing. There was no association between SLC6A9 glycine transporter polymorphisms and alcohol dependence, and also none in haplotype analysis.
Koller
Gabriele
G
Psychiatrische Klinik, Nussbaumstrasse 7, 80336 Munich, Germany. gabi.koller@med.uni-muenchen.de
Zill
Peter
P
Fehr
Christoph
C
Pogarell
Oliver
O
Bondy
Brigitta
B
Soyka
Michael
M
Preuss
Ulrich-Wilkelm
UW
D000437:Alcoholism / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D014644:Genetic Variation / Q000235:genetics; D005838:Genotype; D050487:Glycine Plasma Membrane Transport Proteins / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D015995:Prevalence; D012720:Severity of Illness Index
D050487:Glycine Plasma Membrane Transport Proteins; C493271:SLC6A5 protein, human; C493268:SLC6A9 protein, human