title: Perfusion imaging of the right perisylvian neural network in acute spatial neglect.
abstract: Recent studies have suggested a tightly connected perisylvian neural network associated with spatial neglect. Here we investigated whether structural damage in one part of the network typically is accompanied with functional damage in other, structurally intact areas of this network. By combining normalized fluid-attenuated inversion-recovery (FLAIR) imaging, diffusion-weighted imaging (DWI), and perfusion-weighted imaging (PWI) we asked whether or not lesions centering on fronto-temporal regions co-occur with abnormal perfusion in structurally intact parietal cortex. With thresholds applied to delineate behaviourally relevant malperfusion of brain tissue, the analysis of normalized time-to-peak (TTP) and maximal signal reduction (MSR) perfusion maps did not reveal significant changes outside the area of structural damage. In particular, we found no abnormal perfusion in the structurally intact inferior parietal lobule (IPL) and/or the temporo-parietal junction (TPJ). The present results obtained in three consecutively admitted neglect patients with fronto-temporal lesions indicate that structural damage in one part of the right perisylvian network associated with spatial neglect does not necessarily require dysfunction by malperfusion in other, structurally intact parts of the network to provoke spatial neglect. The neural tissue in the fronto-temporal cortex appears to have an original role in processes of spatial orienting and exploration.
authors.affiliation: Section of Neuropsychology, Center of Neurology, Hertie-Institute for Clinical Brain Research, University of Tübingen Tübingen, Germany. regine.zopf@maccs.mq.edu.au
authors.forename: Regine
authors.initials: R
authors.lastname: Zopf
authors.forename: Monika
authors.initials: M
authors.lastname: Fruhmann Berger
authors.forename: Uwe
authors.initials: U
authors.lastname: Klose
authors.forename: Hans-Otto
authors.initials: HO
authors.lastname: Karnath
references.citation: Neuropsychologia. 2009 Jan;47(1):91-103
references.pmid: 18790703
references.citation: Brain. 2004 Jan;127(Pt 1):99-110
references.pmid: 14570819
references.citation: Neuroradiology. 1997 Jun;39(6):406-10
references.pmid: 9225318
references.citation: Stroke. 2002 Jan;33(1):87-94
references.pmid: 11779894
references.citation: Cerebrovasc Dis. 2001;11 Suppl 1:2-8
references.pmid: 11244194
references.citation: Science. 2005 Sep 30;309(5744):2226-8
references.pmid: 16195465
references.citation: Brain. 2007 Feb;130(Pt 2):431-41
references.pmid: 17008330
references.citation: Neurology. 1999 Oct 22;53(7):1528-37
references.pmid: 10534263
references.citation: Nature. 2001 Jun 21;411(6840):950-3
references.pmid: 11418859
references.citation: AJNR Am J Neuroradiol. 1999 Sep;20(8):1535-42
references.pmid: 10512242
references.citation: Stroke. 1981 Nov-Dec;12(6):723-5
references.pmid: 6272455
references.citation: Neurology. 1998 Aug;51(2):418-26
references.pmid: 9710013
references.citation: J Neuroimaging. 2002 Oct;12(4):330-8
references.pmid: 12380480
references.citation: Cortex. 1997 Jun;33(2):271-85
references.pmid: 9220258
references.citation: AJNR Am J Neuroradiol. 2002 Nov-Dec;23(10):1785-94
references.pmid: 12427640
references.citation: Stroke. 2004 Jan;35(1):94-8
references.pmid: 14671249
references.citation: J Magn Reson Imaging. 2000 Feb;11(2):114-9
references.pmid: 10713942
references.citation: Nat Neurosci. 2005 Nov;8(11):1603-10
references.pmid: 16234807
references.citation: Rofo. 1992 Mar;156(3):207-11
references.pmid: 1550914
references.citation: Brain. 2002 Feb;125(Pt 2):350-60
references.pmid: 11844735
references.citation: Ann Neurol. 1981 Oct;10(4):309-25
references.pmid: 7032417
references.citation: Ann Neurol. 2001 Nov;50(5):561-6
references.pmid: 11706960
references.citation: Brain. 2004 Apr;127(Pt 4):E10; author reply E11
references.pmid: 15044314
references.citation: Neurology. 1972 Jun;22(6):660-4
references.pmid: 4673341
references.citation: J Neurol. 1996 Sep;243(9):652-7
references.pmid: 8892067
references.citation: J Neurosci. 2005 Mar 23;25(12):3161-7
references.pmid: 15788773
references.citation: Ann Neurol. 1999 Oct;46(4):568-78
references.pmid: 10514093
references.citation: Neuroimage. 2001 Aug;14(2):486-500
references.pmid: 11467921
references.citation: Neuropsychologia. 1997 Nov;35(11):1445-58
references.pmid: 9352522
references.citation: Neurology. 1998 Apr;50(4):901-8
references.pmid: 9566370
references.citation: Neuron. 2007 Mar 15;53(6):905-18
references.pmid: 17359924
references.citation: Cereb Cortex. 2009 Oct;19(10):2331-7
references.pmid: 19168667
references.citation: Neurology. 1983 Jun;33(6):797-9
references.pmid: 6682527
references.citation: Nat Neurosci. 2000 Mar;3(3):284-91
references.pmid: 10700262
references.citation: Brain. 2005 Oct;128(Pt 10):2462-9
references.pmid: 16150848
references.citation: Stroke. 1999 Aug;30(8):1591-7
references.pmid: 10436106
references.citation: Magn Reson Med. 1990 Jun;14(3):538-46
references.pmid: 2355835
references.citation: Rofo. 1999 May;170(5):474-81
references.pmid: 10370412
references.citation: Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):17163-8
references.pmid: 17939998
references.citation: Stroke. 1995 Jan;26(1):90-5
references.pmid: 7839405
references.citation: BMC Neurosci. 2009 Mar 03;10:15
references.pmid: 19257886
references.citation: Neuropsychologia. 1986;24(5):609-22
references.pmid: 3785649
references.citation: J Neurol. 2005 Oct;252(10):1194-200
references.pmid: 15895307
references.citation: Neuroimage. 2006 Oct 1;32(4):1747-59
references.pmid: 16806986
references.citation: Cereb Cortex. 2007 Nov;17(11):2479-90
references.pmid: 17272263
references.citation: Stroke. 2000 Jun;31(6):1311-7
references.pmid: 10835450
references.citation: J Clin Exp Neuropsychol. 2004 Apr;26(2):251-6
references.pmid: 15202544
references.citation: J Neuroimaging. 2005 Jul;15(3):254-60
references.pmid: 15951408
references.citation: Brain. 2003 Sep;126(Pt 9):1986-97
references.pmid: 12821519
references.citation: J Neuroimaging. 2006 Oct;16(4):329-33
references.pmid: 17032382
references.citation: Stroke. 1996 Jul;27(7):1187-91
references.pmid: 8685926
references.citation: Behav Neurol. 2000;12(4):191-200
references.pmid: 11568431
references.citation: Brain. 2002 May;125(Pt 5):1094-104
references.pmid: 11960898
references.citation: Cereb Cortex. 2004 Oct;14(10):1164-72
references.pmid: 15142954
references.citation: Stroke. 2002 Apr;33(4):1146-51
references.pmid: 11935075
references.citation: Cerebrovasc Dis. 2000 Nov-Dec;10(6):441-8
references.pmid: 11070374
references.citation: Neurology. 2004 Mar 9;62(5):749-56
references.pmid: 15007125
references.citation: Phys Med Biol. 2003 Jun 7;48(11):1505-17
references.pmid: 12817934
references.citation: Neurology. 1998 Apr;50(4):864-70
references.pmid: 9566364
references.citation: Cortex. 1994 Jun;30(2):319-30
references.pmid: 7924354