title: Impact of fish oil-based lipid emulsion on serum triglyceride, bilirubin, and albumin levels in children with parenteral nutrition-associated liver disease.
abstract: Parenteral nutrition is known to cause liver injury in babies. The aim of this study is to investigate the effects of different lipid emulsions on parenteral nutrition-associated cholestasis in infants. In addition, there may be a relationship between the lipid emulsion and triglyceride levels. Furthermore, triglyceride levels may correlate with direct bilirubin and albumin, as markers of liver impairment and nutritional status. Patients with parenteral nutrition-associated cholestasis who were treated with a fish oil-based lipid emulsion (n = 18) were prospectively followed for triglyceride, direct bilirubin, and albumin levels and compared with patients who were maintained on a soy-based lipid emulsion (n = 59). Triglyceride levels decreased in the fish oil cohort from a mean of 140 mg/dL at wk 0 to 40 mg/dL at wk 20 but remained unchanged at approximately 140 mg/dL in the soybean cohort. Triglyceride levels of patients treated with fish oil declined over time, while those receiving soybean oil did not. Also, changes in triglyceride levels over time were directly correlated with direct bilirubin and inversely related to albumin levels. These findings may indicate an added benefit of reduced triglyceride levels for patients treated with fish oil and this effect coincides with markers for improved liver function and nutritional status.
authors.affiliation: Department of Surgery, Harvard Medical School, 11 Priscilla Road, No. 1, Boston, MA 02135, USA. slee10@bidmc.harvard.edu
authors.forename: Sang I
authors.initials: SI
authors.lastname: Lee
authors.forename: Clarissa
authors.initials: C
authors.lastname: Valim
authors.forename: Patrick
authors.initials: P
authors.lastname: Johnston
authors.forename: Hau D
authors.initials: HD
authors.lastname: Le
authors.forename: Jonathan
authors.initials: J
authors.lastname: Meisel
authors.forename: Danielle A
authors.initials: DA
authors.lastname: Arsenault
authors.forename: Kathleen M
authors.initials: KM
authors.lastname: Gura
authors.forename: Mark
authors.initials: M
authors.lastname: Puder
mesh_terms: D001663:Bilirubin / Q000097:blood*; D002779:Cholestasis / Q000097:blood* / Q000209:etiology; D005217:Fat Emulsions, Intravenous / Q000494:pharmacology*; D005395:Fish Oils / Q000494:pharmacology*; D005858:Germany; D006801:Humans; D007223:Infant; D008404:Massachusetts; D010288:Parenteral Nutrition / Q000009:adverse effects* / Q000379:methods; D012709:Serum Albumin / Q000378:metabolism*; D018709:Statistics, Nonparametric; D014280:Triglycerides / Q000097:blood*
chemical_list: D005217:Fat Emulsions, Intravenous; D005395:Fish Oils; D012709:Serum Albumin; D014280:Triglycerides; D001663:Bilirubin
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