Organocatalytic peroxy-asymmetric allylic alkylation.
The peroxy-asymmetric allylic alkylation of hydroperoxyalkanes with Morita-Baylis-Hillman carbonates was catalysed by modified cinchona alkaloids (up to 93% ee), from which chiral alpha-methylene-beta-hydroxy esters could be efficiently derived.
Feng
Xin
X
Key Laboratory of Drug-Targeting and Drug Delivery System of Education Ministry, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, 610041, China.
Yuan
Yu-Qing
YQ
Cui
Hai-Lei
HL
Jiang
Kun
K
Chen
Ying-Chun
YC
D000475:Alkenes / Q000737:chemistry*; D000478:Alkylation; D002384:Catalysis; D004952:Esters / Q000737:chemistry; D010545:Peroxides / Q000737:chemistry*; D013237:Stereoisomerism
D000475:Alkenes; D004952:Esters; D010545:Peroxides