title: Influence of quaternary conformation on the biological activities of the Asp49-phospholipases A2s from snake venoms.
abstract: One of the main components of snake venoms are the Asp49-phospholipases A(2), also known as svPLA(2)s. The study of these toxins is a matter of great scientific interest due to their wide variety of biological effects. In this work we present strong evidences found in literature and other aspects which strengthen the importance of quaternary assembly for understanding the activities and molecular evolution of svPLA(2)s.
authors.affiliation: Departamento de Física e Biofísica, Instituto de Biociências, UNESP, Botucatu/SP, Brasil.
authors.forename: Angelo J
authors.initials: AJ
authors.lastname: Magro
authors.forename: Carlos A H
authors.initials: CA
authors.lastname: Fernandes
authors.forename: Juliana I
authors.initials: JI
authors.lastname: dos Santos
authors.forename: Marcos R M
authors.initials: MR
authors.lastname: Fontes
mesh_terms: D000818:Animals; D008958:Models, Molecular; D054467:Phospholipases A2 / Q000737:chemistry* / Q000378:metabolism; D011487:Protein Conformation; D055503:Protein Multimerization; D012910:Snake Venoms / Q000201:enzymology*; D012911:Snakes
chemical_list: D012910:Snake Venoms; D054467:Phospholipases A2