[Modern genetic approaches to the search for targets for medicinal preparations].
In spite of a vast number of drug preparations used in medicine, advances in treating most socially important human diseases remain modest. Historically, many drugs were developed without clear understanding of the mechanisms of their action and were aimed only at correcting symptoms of the disease. Identification of molecular targets in pharmacological screening of new pharmaceuticals plays a key role not only in defining the strategy of the treatment, but also in understanding the general development of the disease. Sequencing of the genomes of various organisms, human in particular, and the development of new modern techniques of research have created the prerequisites for targeted screening for genes that are potentially interesting for designing new drugs.
Sarantseva
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Shvartsman
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D000818:Animals; D055808:Drug Discovery; D004353:Drug Evaluation, Preclinical; D055879:Gene Knock-In Techniques; D055786:Gene Knockout Techniques; D005821:Genetic Techniques; D015316:Genetic Therapy / Q000379:methods*; D023281:Genomics; D006801:Humans; D009154:Mutation; D020543:Proteome / Q000235:genetics; D034622:RNA Interference; D014614:Vaccines, Synthetic
D020543:Proteome; D014614:Vaccines, Synthetic