title: [Distribution of aconitum alkaloids in the corpse died of acute aconite intoxication].
abstract: OBJECTIVE
  To investigate the distribution of aconite alkaloids in biological fluids and tissues in the corpse died of acute aconite intoxication and to provide information for sample selection and result evaluation in forensic identification.
  
  
  METHODS
  The content of aconite alkaloids in biological fluids and tissues were determined by liquid chromatography-tandem mass spectrometry.
  
  
  RESULTS
  The content of aconite displayed in decending order of urine, bile, gastric content, heart blood, pancreas, heart, intestine, liver, kidney, stomach, lung, gallbladder and spleen, with no aconite detected in the brain.
  
  
  CONCLUSIONS
  It was indicated that urine, bile and blood are the best specimens for the determination of aconite in body of the acute aconite intoxication.
authors.affiliation: Department of Forensic Medicine, Shanghai Medical College, Fudan University, Shanghai 200032, China. liuwei0806@yahoo.com.cn
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.forename: Min
authors.initials: M
authors.lastname: Shen
authors.forename: Zhi-Qiang
authors.initials: ZQ
authors.lastname: Qin
mesh_terms: D000157:Aconitine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000652:urine; D031841:Aconitum / Q000737:chemistry / Q000506:poisoning*; D000208:Acute Disease; D001646:Bile / Q000737:chemistry*; D002853:Chromatography, Liquid / Q000379:methods; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000506:poisoning*; D005554:Forensic Medicine; D008401:Gas Chromatography-Mass Spectrometry; D005753:Gastric Mucosa / Q000378:metabolism*; D006801:Humans; D008099:Liver / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D014018:Tissue Distribution
chemical_list: D004365:Drugs, Chinese Herbal; C058309:hypaconitine; D000157:Aconitine