Differences in effects of Zuojin Pills and its similar formulas on Wei cold model in rats.
OBJECTIVE
To explore the effects of Zuojin Pills and its similar formulas on the stomach cold syndrome in a Wei cold model in rats.


METHODS
The rat Wei cold model was established by intragastric administration of glacial NaOH, and the gastric mucosa injury indices, together with the levels of motilin and gastrin in the stomach, were determined. The preventive and curative effects of Zuojin Pills and its similar formulas on gastric mucosa injury were investigated.


RESULTS
Zuojin Pills and its similar formulas could protect the gastric mucosa in the gastric cold model in rats at different levels. Fanzuojin Pills had the best effect in inhibiting gastric mucosa injury.


CONCLUSIONS
The different pharmacological effects of Zuojin Pills and its similar formulas in the rat gastric cold model were partially correlated with the degrees in cold and heat properties of the formulas.
Zhao
Yan-ling
YL
Institute of Traditional Chinese Material Medica, the 302 Hospital of PLA, Beijing, 100039, China.
Shi
Wen-li
WL
Shan
Li-mei
LM
Wang
Jia-bo
JB
Zhao
Hai-ping
HP
Xiao
Xiao-he
XH
D000818:Animals; D002626:Chemistry, Pharmaceutical; D003080:Cold Temperature; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000187:drug effects / Q000473:pathology; D008315:Malondialdehyde / Q000097:blood; D051381:Rats; D017207:Rats, Sprague-Dawley; D013272:Stomach Diseases / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D013482:Superoxide Dismutase / Q000097:blood; D013607:Tablets; D013810:Therapeutic Equivalency
D004365:Drugs, Chinese Herbal; D013607:Tablets; C545320:zuojin; D008315:Malondialdehyde; D013482:Superoxide Dismutase
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