Vitamin D-resistant rickets type II-A, basal ganglia calcification, and catatonia: a casual or causal relationship?
BACKGROUND
Vitamin D-resistant rickets type-IIA (VDRR-IIA) is a rare, congenital, metabolic disorder characterized by hypocalcemia, rickets, and alopecia. There are reports correlating calcium-metabolic disorders with basal ganglia calcification (BGC) and neuropsychiatric symptoms.


OBJECTIVE
The authors document and discuss the relationships of these phenomena.


METHODS
The authors describe a patient born with VDRR-IIA who subsequently developed BGC at age 15, and catatonic symptoms of progressive severity at age 16.


RESULTS
There appeared to be a positive correlation between the severity of BGC and neuropsychiatric symptoms.


CONCLUSIONS
This is the first time VDRR-IIA, BGC, and catatonia have been reported in a patient, and the authors discuss the relationship among the conditions.
Brunoni
André Russowsky
AR
correspondence and M.D., Institute of Psychiatry, University of São Paulo, Alameda Fernao Cardim 346/101 Postal Code: 01403-01020, São Paulo (SP), Brazil. brunowsky@gmail.com
Nakata
Ana C G
AC
Tung
Teng Chei
TC
Busatto
Geraldo F
GF
D001479:Basal Ganglia / Q000473:pathology*; D002114:Calcinosis / Q000209:etiology / Q000473:pathology; D002389:Catatonia / Q000209:etiology* / Q000473:pathology; D053098:Familial Hypophosphatemic Rickets / Q000150:complications* / Q000473:pathology; D006801:Humans; D008297:Male; D055815:Young Adult