Interactions of sex hormone-binding globulin with target cells.
Sex hormone-binding globulin (SHBG) was initially described as a plasma protein synthesized in, and secreted by, the liver. It was discovered by its ability to bind certain androgens and estrogens and, for many years, was believed to serve as a transporter/reservoir for the steroids which it bound. Subsequently, it became clear that the cell membranes of selected tissues contained a receptor for SHBG (R(SHBG)). This review deals with what is known of that receptor - its anatomy, physiology and biochemistry.
Rosner
William
W
Department of Medicine, St. Luke's/Roosevelt Hospital Center, College of, Physicians and Surgeons, Columbia University, New York, NY 10019, USA. wr7@columbia.edu
Hryb
Daniel J
DJ
Kahn
Scott M
SM
Nakhla
Atif M
AM
Romas
Nicholas A
NA
D000728:Androgens / Q000378:metabolism; D000818:Animals; D002462:Cell Membrane / Q000378:metabolism*; D000242:Cyclic AMP / Q000378:metabolism; D004967:Estrogens / Q000378:metabolism; D006801:Humans; D008099:Liver / Q000378:metabolism; D011485:Protein Binding; D011956:Receptors, Cell Surface / Q000378:metabolism*; D012738:Sex Hormone-Binding Globulin / Q000235:genetics / Q000378:metabolism*
D000728:Androgens; D004967:Estrogens; D011956:Receptors, Cell Surface; D012738:Sex Hormone-Binding Globulin; D000242:Cyclic AMP