Determination of trimester specific reference intervals for thyroid hormones during pregnancy in Malaysian women.
OBJECTIVE
To establish trimester specific reference intervals for thyroid hormones during pregnancy in Malaysian women.


METHODS
Cross-sectional observational study performed in the Obstetric Clinic, University Malaya Medical Centre. A single blood sample from 626 women at various trimesters of pregnancy was analyzed for thyroid function. TSH, FT4, TT4, FT3 and TT3 values at each trimester of pregnancy were calculated.


RESULTS
From the TSH, FT4, TT4, FT3 and TT3 results, reference values based on mean +/- 2SD was calculated for the hormones at each trimester of pregnancy.


CONCLUSIONS
We calculated clinically relevant trimester-specific reference values for thyroid function tests through pregnancy to facilitate improved management of thyroid disease in pregnancy in our local population.
Thevarajah
M
M
Department of Pathology, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia. tmalathi@um.edu.my
Chew
Y Y
YY
Lim
S C
SC
Sabir
N
N
Sickan
J
J
D000328:Adult; D005260:Female; D006785:Hospitals, University; D006801:Humans; D008875:Middle Aged; D011247:Pregnancy; D011264:Pregnancy Trimesters / Q000097:blood*; D012016:Reference Values; D013961:Thyroid Gland / Q000502:physiology*; D013963:Thyroid Hormones / Q000097:blood*; D055815:Young Adult
D013963:Thyroid Hormones