Recent advances in the identification of gamma-secretase inhibitors to clinically test the Abeta oligomer hypothesis of Alzheimer's disease.
Kreft
Anthony F
AF
Wyeth Research, CN 8000, Princeton, New Jersey 08543, USA.
Martone
Robert
R
Porte
Alexander
A
D000544:Alzheimer Disease / Q000188:drug therapy* / Q000201:enzymology* / Q000378:metabolism / Q000503:physiopathology; D053829:Amyloid Precursor Protein Secretases / Q000037:antagonists & inhibitors*; D016229:Amyloid beta-Peptides / Q000096:biosynthesis / Q000378:metabolism*; D000818:Animals; D055808:Drug Discovery / Q000379:methods* / Q000639:trends; D006801:Humans; D008954:Models, Biological; D011480:Protease Inhibitors / Q000737:chemistry / Q000145:classification / Q000494:pharmacology* / Q000627:therapeutic use*
D016229:Amyloid beta-Peptides; D011480:Protease Inhibitors; D053829:Amyloid Precursor Protein Secretases