title: Nitric oxide and clustering of metabolic syndrome components in pediatrics.
abstract: This study was performed to determine the risk factor pattern of the metabolic syndrome (MetS) in association with serum nitric oxide metabolites (NO(x)) in children and adolescents. The study included 851 children and adolescents, aged 4-19 years. The MetS was defined according to modified Adult treatment Panel III criteria. Cluster analysis was performed using principle components analysis with varimax orthogonal rotation to examine the risk factor pattern of the MetS. The prevalence of MetS was 10.8 and 10.0% in males and females, respectively. Age-and sex-adjusted odds ratio of having MetS was significantly higher in the upper quartile of NO(x) compared to the lower quartile (2.2, 95% CI: 1.1-4.7, p = 0.029). In the whole population, three factors were identified including blood pressure/obesity, lipid/obesity, and glucose/NO(x). Stratifying for sex, again three factors were retained; however, in males NO(x) was loaded in two factors. In conclusion, serum NO( x ) was associated and loaded with other MetS components in cluster analysis of metabolic risk factors.
authors.affiliation: Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, P.O. Box 19395-4763, Tehran, Iran.
authors.forename: Asghar
authors.initials: A
authors.lastname: Ghasemi
authors.forename: Saleh
authors.initials: S
authors.lastname: Zahediasl
authors.forename: Fereidoun
authors.initials: F
authors.lastname: Azizi
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D016000:Cluster Analysis; D003430:Cross-Sectional Studies; D005260:Female; D016166:Free Radical Scavengers / Q000378:metabolism*; D006801:Humans; D007492:Iran / Q000453:epidemiology; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology / Q000209:etiology*; D009569:Nitric Oxide / Q000097:blood / Q000378:metabolism*; D009765:Obesity; D010372:Pediatrics; D018570:Risk Assessment; D012307:Risk Factors; D055815:Young Adult
chemical_list: D016166:Free Radical Scavengers; D009569:Nitric Oxide
references.citation: Am J Epidemiol. 2000 Nov 15;152(10):908-11; discussion 912
references.pmid: 11092432
references.citation: Hypertension. 1997 Sep;30(3 Pt 1):405-8
references.pmid: 9314424
references.citation: BMJ. 2000 May 6;320(7244):1240-3
references.pmid: 10797032
references.citation: Clin Chim Acta. 2002 Oct;324(1-2):113-20
references.pmid: 12204432
references.citation: JAMA. 2003 Nov 5;290(17):2271-6
references.pmid: 14600185
references.citation: Life Sci. 2008 Apr 9;82(15-16):892-8
references.pmid: 18342892
references.citation: Int J Obes Relat Metab Disord. 2004 Jul;28(7):833-41
references.pmid: 15170466
references.citation: Diab Vasc Dis Res. 2007 Dec;4(4):285-96
references.pmid: 18158698
references.citation: Diabetes. 2004 Jul;53(7):1773-81
references.pmid: 15220201
references.citation: Life Sci. 2008 Aug 29;83(9-10):326-31
references.pmid: 18662705
references.citation: Am J Hum Biol. 2007 Jan-Feb;19(1):34-40
references.pmid: 17160982
references.citation: Pediatrics. 2007 Aug;120(2):340-5
references.pmid: 17671060
references.citation: Obesity (Silver Spring). 2006 Mar;14(3):377-82
references.pmid: 16648607
references.citation: Clin Chim Acta. 2004 Sep;347(1-2):151-6
references.pmid: 15313153
references.citation: Environ Health Prev Med. 2008 Jan;13(1):36-42
references.pmid: 19568878
references.citation: Pediatrics. 2004 Aug;114(2 Suppl 4th Report):555-76
references.pmid: 15286277
references.citation: Circulation. 2006 Apr 18;113(15):1888-904
references.pmid: 16618833
references.citation: Diabetes Res Clin Pract. 2003 Jul;61(1):29-37
references.pmid: 12849921
references.citation: Clin Biochem. 2004 Aug;37(8):666-72
references.pmid: 15302608
references.citation: Int J Obes (Lond). 2008 May;32(5):826-31
references.pmid: 18197180
references.citation: Arch Intern Med. 1994 Aug 22;154(16):1842-7
references.pmid: 8053753
references.citation: Am J Physiol Endocrinol Metab. 2000 Jul;279(1):E11-7
references.pmid: 10893317
references.citation: Eur J Pediatr. 2008 Oct;167(10):1183-9
references.pmid: 18205011
references.citation: Diabetes Care. 2006 Jan;29(1):113-22
references.pmid: 16373906
references.citation: Ann Nutr Metab. 2007;51(3):208-15
references.pmid: 17587791
references.citation: Clin Biochem. 2008 Nov;41(16-17):1342-7
references.pmid: 18793628
references.citation: J Pediatr. 2008 Feb;152(2):160-4
references.pmid: 18206681
references.citation: Trends Pharmacol Sci. 2000 Jul;21(7):249-52
references.pmid: 10979862
references.citation: Clin Cardiol. 1997 Apr;20(4):361-5
references.pmid: 9098596
references.citation: Nitric Oxide. 2007 Feb;16(1):157-63
references.pmid: 16889997
references.citation: Tohoku J Exp Med. 2003 Feb;199(2):95-110
references.pmid: 12705354
references.citation: Soz Praventivmed. 2002;47(6):408-26
references.pmid: 12643001
references.citation: Horm Metab Res. 2002 Jul;34(7):394-9
references.pmid: 12189588
references.citation: Am J Epidemiol. 1999 Oct 1;150(7):667-74
references.pmid: 10512420
references.citation: Diabetes Care. 2007 Jun;30(6):1556-61
references.pmid: 17363752
references.citation: Nat Med. 2001 Oct;7(10):1138-43
references.pmid: 11590438
references.citation: JAMA. 2001 May 16;285(19):2486-97
references.pmid: 11368702
references.citation: Indian J Pediatr. 2003 Aug;70(8):625-8
references.pmid: 14510082
references.citation: Circulation. 2005 Apr 19;111(15):1970-7
references.pmid: 15837951
references.citation: Am J Epidemiol. 2000 Nov 15;152(10):897-907
references.pmid: 11092431
references.citation: Clin Biochem. 2003 Sep;36(6):413-20
references.pmid: 12951167
references.citation: J Clin Invest. 1997 Jul 15;100(2):290-5
references.pmid: 9218505
references.citation: Arch Iran Med. 2008 Mar;11(2):242-5
references.pmid: 18298310
references.citation: Am J Epidemiol. 1991 May 1;133(9):884-99
references.pmid: 2028978
references.citation: Atherosclerosis. 2008 Apr;197(2):638-45
references.pmid: 17945241
references.citation: Clin Chem. 2001 Jun;47(6):1106-9
references.pmid: 11375300
references.citation: Clin Exp Pharmacol Physiol. 2007 Aug;34(8):725-31
references.pmid: 17600548