title: Brown recluse spider venom: proteomic analysis and proposal of a putative mechanism of action.
abstract: Loxosceles intermedia spider venom was subjected to proteomic analysis through a MudPIT shot-gun approach to identify the protein composition. Were identified 39 proteins which seem to responsible by the lesion of different types of tissues, to some physiopathological actions and by the prevention of structural damage to the toxin structures.
authors.affiliation: Laboratory of Structural Biology and Zoochemistry, CEIS/Dept. Biology, Institute of Biosciences of Rio Claro, São Paulo State University (UNES), Rio Claro, SP, Brazil.
authors.forename: Lucilene D
authors.initials: LD
authors.lastname: dos Santos
authors.forename: Nathalia B
authors.initials: NB
authors.lastname: Dias
authors.forename: José
authors.initials: J
authors.lastname: Roberto
authors.forename: A S
authors.initials: AS
authors.lastname: Pinto
authors.forename: Mario S
authors.initials: MS
authors.lastname: Palma
mesh_terms: D000818:Animals; D006801:Humans; D013058:Mass Spectrometry; D010727:Phosphoric Diester Hydrolases / Q000032:analysis* / Q000378:metabolism / Q000633:toxicity; D011506:Proteins / Q000032:analysis* / Q000378:metabolism / Q000633:toxicity; D020543:Proteome / Q000032:analysis; D012909:Snake Bites / Q000503:physiopathology; D013111:Spider Venoms / Q000032:analysis* / Q000378:metabolism / Q000633:toxicity; D013112:Spiders
chemical_list: D011506:Proteins; D020543:Proteome; D013111:Spider Venoms; C055161:loxosceles venom; D010727:Phosphoric Diester Hydrolases