title: Application of chemometric assisted dispersive liquid-liquid microextraction to the determination of personal care products in natural waters.
abstract: A rapid and simple method for the determination of two phthalates and five polycyclic musks in water samples using dispersive liquid-liquid microextraction (DLLME) mated to chemometrics and coupled to GC-MS was developed. Volume of extraction (CCl4) and disperser solvent (MeOH), pH, ionic strength, extraction time, centrifugation time as well as centrifugation speed were optimized in a 2(7-4) Plackett-Burman design. The obtained significant factors were optimized by using a central composite design (CCD) and the quadratic model between the dependent and the independent variables was built. The optimum experimental conditions of the proposed method were: 250 microL carbon tetrachloride, 0.62 mL methanol, 7.5 min centrifugation time, natural pH containing 0% (w/v) NaCl, while keeping centrifugation speed fixed at 4000 rpm. The calculated calibration curves gave high-level linearity for all target analytes with correlation coefficients ranging between 0.9970 and 0.9992. The repeatability and reproducibility of the proposed method, expressed as relative standard deviation, varied between 2.6% to 9.7% and 5.7% to 12.2%, respectively. The obtained LOD values were in the range of 8-63 ng L(-1).
authors.affiliation: Department of Chemistry, University of Ioannina, Ioannina 45110, Greece.
authors.forename: Aikaterini N
authors.initials: AN
authors.lastname: Panagiotou
authors.forename: Vasilios A
authors.initials: VA
authors.lastname: Sakkas
authors.forename: Triantafyllos A
authors.initials: TA
authors.lastname: Albanis
mesh_terms: D005618:Fresh Water / Q000032:analysis*; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009994:Osmolar Concentration; D010795:Phthalic Acids / Q000032:analysis* / Q000302:isolation & purification; D011083:Polycyclic Compounds / Q000032:analysis* / Q000302:isolation & purification; D012997:Solvents / Q000737:chemistry; D014874:Water Pollutants, Chemical / Q000032:analysis* / Q000302:isolation & purification
chemical_list: D010795:Phthalic Acids; D011083:Polycyclic Compounds; D012997:Solvents; D014874:Water Pollutants, Chemical; C032279:phthalic acid