A model for cortical rewiring following deafferentation and focal stroke.
It is still unclear to what extent structural plasticity in terms of synaptic rewiring is the cause for cortical remapping after a lesion. Recent two-photon laser imaging studies demonstrate that synaptic rewiring is persistent in the adult brain and is dramatically increased following brain lesions or after a loss of sensory input (cortical deafferentation). We use a recurrent neural network model to study the time course of synaptic rewiring following a peripheral lesion. For this, we represent axonal and dendritic elements of cortical neurons to model synapse formation, pruning and synaptic rewiring. Neurons increase and decrease the number of axonal and dendritic elements in an activity-dependent fashion in order to maintain their activity in a homeostatic equilibrium. In this study we demonstrate that synaptic rewiring contributes to neuronal homeostasis during normal development as well as following lesions. We show that networks in homeostasis, which can therefore be considered as adult networks, are much less able to compensate for a loss of input. Interestingly, we found that paused stimulation of the networks are much more effective promoting reorganization than continuous stimulation. This can be explained as neurons quickly adapt to this stimulation whereas pauses prevents a saturation of the positive stimulation effect. These findings may suggest strategies for improving therapies in neurologic rehabilitation.
Butz
Markus
M
Bernstein Center for Computational Neuroscience Göttingen, University of Göttingen Göttingen, Germany.
van Ooyen
Arjen
A
Wörgötter
Florentin
F
Nature. 1998 Feb 26;391(6670):892-6
9495341
J Neural Transm (Vienna). 2006 May;113(5):695-710
16463119
J Neurol. 2001 Apr;248(4):315-21
11374097
J Neurosci. 1995 Mar;15(3 Pt 1):1631-47
7891124
J Neurosci. 2004 Jan 21;24(3):628-33
14736848
Nat Protoc. 2007;2(7):1675-84
17641632
Neurobiol Learn Mem. 2002 Jan;77(1):63-77
11749086
Neurobiol Dis. 2001 Oct;8(5):910-22
11592858
Curr Opin Neurobiol. 2007 Jun;17(3):318-24
17451937
Eur J Neurosci. 1995 Feb 1;7(2):180-91
7538854
Neuron. 1996 Jul;17(1):91-102
8755481
Nature. 1999 May 6;399(6731):66-70
10331391
Curr Opin Neurobiol. 2000 Jun;10(3):358-64
10851171
Nat Neurosci. 2006 Sep;9(9):1117-24
16892056
Neuron. 2004 Dec 2;44(5):759-67
15572108
Neuron. 2001 Mar;29(3):779-96
11301036
Neuroscience. 1983 Nov;10(3):639-65
6646426
Neural Netw. 2006 Dec;19(10):1490-505
17014989
Neuroscience. 2007 Mar 16;145(2):464-9
17240073
J Neurophysiol. 1996 Jan;75(1):217-32
8822553
Proc Natl Acad Sci U S A. 2006 Jul 11;103(28):10805-10
16818873
Nature. 2002 Mar 28;416(6879):430-3
11919632
Nat Rev Neurosci. 2005 Nov;6(11):877-88
16261181
J Neurosci. 2002 Jul 15;22(14):6062-70
12122067
Neuron. 2002 Apr 11;34(2):265-73
11970868
BMC Neurosci. 2003 Oct 15;4:26
14575529
Annu Rev Neurosci. 2001;24:1071-89
11520928
Neuroscience. 2002;111(4):709-38
12031401
Biol Cybern. 1988;58(3):149-58
3358950
Nat Neurosci. 2007 Jun;10(6):727-34
17486101
Biol Cybern. 2002 Dec;87(5-6):333-43
12461624
J Neurosci Methods. 1986 Dec;18(4):333-8
3540472
Ann Neurol. 1998 Aug;44(2):255-8
9708549
J Theor Biol. 1995 Jan 7;172(1):63-82
7891450
Neuron. 2002 Apr 11;34(2):275-88
11970869
Nature. 1994 Apr 21;368(6473):737-40
8152484
Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3555-60
19221032
Nat Neurosci. 2000 Sep;3(9):887-94
10966619
Biol Cybern. 1986;54(4-5):211-22
3017460
J Comp Neurol. 2005 Apr 4;484(2):183-90
15736233
Trends Neurosci. 1989 Jul;12(7):265-70
2475939
Nature. 2004 Oct 14;431(7010):782-8
15483599
Neurobiol Learn Mem. 2007 Feb;87(2):225-35
17056284
Ann Neurol. 2006 May;59(5):735-42
16634041
J Neurosci. 1988 May;8(5):1704-11
2835450
Clin Neurophysiol. 2000 Apr;111(4):671-6
10727918
Neurosci Lett. 1995 Jun 30;193(2):101-4
7478151
Ann Anat. 1992 Oct;174(5):393-403
1449216
Brain Res Rev. 2009 May;60(2):287-305
19162072
Neuron. 2006 Mar 16;49(6):861-75
16543134
Stroke. 1995 Nov;26(11):2135-44
7482662
Nat Neurosci. 2008 Oct;11(10):1162-7
18758460
Trends Neurosci. 1999 May;22(5):221-7
10322495
Neuron. 2007 Jun 21;54(6):961-72
17582335
J Neurophysiol. 1996 Jan;75(1):200-16
8822552
Nature. 2002 Dec 19-26;420(6917):788-94
12490942
Neuropharmacology. 2004 Oct;47(5):640-8
15458835
J Comp Neurol. 1984 Apr 20;224(4):591-605
6725633
Nature. 2005 May 19;435(7040):300-7
15902248
Eur J Neurosci. 2007 May;25(10):3185-92
17561832
J Neurosci. 1998 Nov 1;18(21):8900-11
9786995
Nat Neurosci. 2007 Jul;10(7):887-95
17529985
J Neurophysiol. 1996 Jan;75(1):184-99
8822551
Stroke. 2007 Feb;38(2 Suppl):840-5
17261749
Neuron. 2002 Apr 11;34(2):175-7
11970858
Brain Res. 1988 Apr-Jun;472(2):179-212
2898278
NeuroRehabilitation. 2007;22(2):133-40
17656839
Hippocampus. 2008;18(9):879-98
18481284
J Cereb Blood Flow Metab. 1996 Sep;16(5):906-14
8784234
Neural Netw. 2006 Jul-Aug;19(6-7):723-33
16774731
Science. 1994 May 13;264(5161):974-7
8178157