title: Analysis of optimized profiles for 'aberration-free' refractive surgery.
abstract: OBJECTIVE
  To provide a model of an aberration-free profile and to clinically evaluate the impact of treatments based upon these theoretical profiles in the post-operative cornea.
  
  
  METHODS
  Aberration-free profiles were deduced from the Zernike expansion of the difference between two corneal cartesian-ovals. Compensation for the focus-shift effects of removing corneal tissue were incorporated by preserving the location of the optical focus of the anterior corneal surface. Simulation of the surgical performance of the profile was performed by means of simulated ray-tracing through a cornea described by its anterior surface and pachymetry. Clinical evaluation was retrospectively analysed in terms of visual outcomes, corneal wavefront aberration and asphericity changes at 3-month follow-up compared to the baseline on 100 eyes treated for compound myopic astigmatism.
  
  
  RESULTS
  The proposed 'aberration-free' profiles theoretically preserve aberrations, becoming more oblate asphericity after myopic treatments, and more prolate after hyperopic ones. In the clinical evaluation, 94% of eyes were within +/-0.50 D of emmetropia. BSCVA improved significantly (p < 0.001). Induced corneal aberrations at 6-mm were below clinically relevant levels: 0.123 +/- 0.129 microm for HO-RMS (p < 0.001), 0.065 +/- 0.128 microm for spherical aberration (p < 0.001) and 0.058 +/- 0.128 microm for coma (p < 0.01), whereas the rate of induced aberrations per achieved D of correction were -0.042, -0.031, and -0.030 microm D(-1) for HO-RMS, SphAb, and coma (all p < 0.001). Induction of positive asphericity correlated to achieved correction (p < 0.001) at a rate 3x theoretical prediction.
  
  
  CONCLUSIONS
  'Aberration-free' patterns for refractive surgery as defined here together with consideration of other sources of aberrations such as blending zones, eye-tracking, and corneal biomechanics yielded results comparable to those of customisation approaches. Having close-to-ideal profiles should improve clinical outcomes decreasing the need for nomograms, and diminishing induced aberrations after surgery.
authors.affiliation: Grupo de Investigación de Cirugía Refractiva y Calidad de Visión, Instituto de Oftalmobiología Aplicada, University of Valladolid, Valladolid, E-47005, Spain. samuel.arba.mosquera@eye-tech.net
authors.forename: Samuel
authors.initials: S
authors.lastname: Arba-Mosquera
authors.forename: Diego
authors.initials: D
authors.lastname: de Ortueta
mesh_terms: D000328:Adult; D003315:Cornea / Q000502:physiology / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008962:Models, Theoretical; D012030:Refractive Errors / Q000503:physiopathology*; D054140:Refractive Surgical Procedures / Q000706:statistics & numerical data*; D055815:Young Adult