[In vitro activity of gallic acid against Candida albicans biofilms].
OBJECTIVE
To investigate the effects of gallic acid against Candida albicans biofilms in vitro.


METHODS
XTT reduction assay was performed to determine the effect of gallic acid on C. albicans biofilms and its adherence, and microscopic examination was conducted to assess the effect of gallic acid on morphogenesis of C. albicans biofilms; and cytotoxic assay was used to measure the adverse effects of gallic acid.


RESULTS
SMIC50, SMIC50 of gallic acid against C. albicans biofilms were 500, 1000 mg x L(-1), respectively; 100 mg x L(-1) and 1000 mg x L(-1) of gallic acid could inhibit the initial adherence and filamentous growth, and the agent showed poor cytotoxic activity.


CONCLUSIONS
gallic acid displayed potent activity against C. albicans biofilm.
Wang
Changzhong
C
School of Integrated Traditional and Western Medicine, Anhui University of Traditional Chinese Medicine, Hefei 230038, China. ahwcz63@sina.com
Cheng
Huijuan
H
Guan
Yan
Y
Wang
Yan
Y
Yun
Yun
Y
D018441:Biofilms / Q000187:drug effects*; D002176:Candida albicans / Q000166:cytology / Q000187:drug effects* / Q000502:physiology*; D002448:Cell Adhesion / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005707:Gallic Acid / Q000494:pharmacology*
D005707:Gallic Acid