title: In vitro antibacterial activities of a novel oxazolidinone, OCID0050.
abstract: OBJECTIVE
  In the pursuit of developing a second-generation oxazolidinone, we have identified OCID0050 as a novel oxazolidinone with enhanced activity against bacterial strains resistant to methicillin, vancomycin and linezolid.
  
  
  METHODS
  MIC and MBC determinations were performed according to CLSI guidelines. Linezolid-resistant bacterial strains were generated in-house; inoculum effect, pH effect and kill kinetics experiments were performed as per standard protocols.
  
  
  CONCLUSIONS
  OCID0050 demonstrated better inhibitory potency against many of the tested clinically significant strains by generally showing 2-4-fold lower MICs than linezolid. In addition, it has higher inhibitory activity against linezolid-resistant strains.
authors.affiliation: Anti-infectives Discovery, Department of Microbiology, Orchid Research Laboratories Ltd, 476/14, OMR, Sholinganallur, Chennai 600 119 (TN), India. ipm@orchidpharma.com
authors.forename: Maneesh
authors.initials: M
authors.lastname: Paul-Satyaseela
authors.forename: Shakti Singh
authors.initials: SS
authors.lastname: Solanki
authors.forename: Devarajan
authors.initials: D
authors.lastname: Sathishkumar
authors.forename: Thirunavukkarasu
authors.initials: T
authors.lastname: Bharani
authors.forename: Vijayan
authors.initials: V
authors.lastname: Magesh
authors.forename: Sriram
authors.initials: S
authors.lastname: Rajagopal
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D024881:Drug Resistance, Bacterial; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000379:methods; D050296:Microbial Viability / Q000187:drug effects; D023303:Oxazolidinones / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; C545472:OCID0050; D023303:Oxazolidinones