title: Factors involved in free flap thrombosis after reconstructive surgery for head and neck cancer.
abstract: OBJECTIVE
  Reconstructive surgery in which a free flap is used following extended resection for head and neck cancer has been popular for more than a quarter of a century. However, postoperative total flap necrosis has not been completely resolved, and few studies have analyzed the specific risk factors for this complication.
  
  
  METHODS
  Over a three-year period from 2005 to 2007, 388 flaps were used for reconstructive surgery on 384 patients at Department of Head and Neck of the Cancer Institute Hospital of Japanese Foundation for Cancer Research, and the results for 22 flaps with thrombosis were analyzed.
  
  
  RESULTS
  The only statistically significant risk factor for free flap thrombosis was the history of radical concurrent chemoradiotherapy.
  
  
  CONCLUSIONS
  It will be necessary to keep this observation in mind when performing salvage surgery following chemoradiotherapy, which is expected to be performed more often in the future.
authors.affiliation: Department of Head and Neck, Cancer Institute Hospital of Japanese Foundation for Cancer Research, 3-10-6 Ariake, Koto-ku, Tokyo, Japan. seyoshim@ncc.go.jp
authors.forename: Seiichi
authors.initials: S
authors.lastname: Yoshimoto
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Kawabata
authors.forename: Hiroki
authors.initials: H
authors.lastname: Mitani
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006083:Graft Occlusion, Vascular / Q000175:diagnosis* / Q000601:surgery; D006085:Graft Survival / Q000502:physiology; D006801:Humans; D008297:Male; D008866:Microsurgery; D008875:Middle Aged; D009336:Necrosis; D010039:Otorhinolaryngologic Neoplasms / Q000601:surgery*; D011183:Postoperative Complications / Q000175:diagnosis* / Q000601:surgery; D012086:Reoperation; D013524:Surgical Flaps / Q000098:blood supply*; D013927:Thrombosis / Q000175:diagnosis* / Q000601:surgery