title: Antioxidant vitamins and glucose-6-phosphate dehydrogenase deficiency in full-term neonates.
abstract: OBJECTIVE
  The mechanism by which glucose-6-phosphate dehydrogenase (G6PD) deficiency causes neonatal hyperbilirubinemia is not completely understood. However, the genetic disorder G6PD deficiency predisposes red blood cells to oxidative stress. The aim of this study was to establish the relationship between plasma antioxidant vitamin (E and C) levels and the development of hyperbilirubinemia in full-term neonates with deficient G6PD.
  
  
  METHODS
  A total of 196 live birth neonates of healthy mothers were included in this study. Twelve of them were deficient in G6PD. In addition to demographic data, serum total bilirubin, hemoglobin, hematocrit, and vitamin E and C levels were measured on the first day after birth.
  
  
  RESULTS
  Neonates with G6PD deficiency (n=7) who did not develop hyperbilirubinemia (mean serum bilirubin level of 70.8+/-23 micromol/l, median 71.8) and neonates with G6PD deficiency (n=4) who developed hyperbilirubinemia (mean serum bilirubin level of 226.7+/-79 micromol/l, median 233.4) on the first day of life had similar gestational weights and age. The second group, however, had lower hemoglobin and hematocrit as well as plasma vitamin C and E levels. None of these results showed significant difference.
  
  
  CONCLUSIONS
  The results of the present study indicate that red blood cell hemolysis as a result of inadequate antioxidants system in G6PD-deficient neonates is not the only contributing factor for hyperbilirubinemia.
authors.affiliation: Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan. kkalani@just.edu.jo
authors.forename: Khalid K
authors.initials: KK
authors.lastname: Abdul-Razzak
authors.forename: Enaam M
authors.initials: EM
authors.lastname: Almomany
authors.forename: Mohamad K
authors.initials: MK
authors.lastname: Nusier
authors.forename: Ahmad D
authors.initials: AD
authors.lastname: Obediat
authors.forename: Ahmad M
authors.initials: AM
authors.lastname: Salim
references.citation: Pediatr Int. 2005 Jun;47(3):258-61
references.pmid: 15910447
references.citation: J Biol Chem. 1988 Dec 25;263(36):19809-14
references.pmid: 3198651
references.citation: Ger Med Sci. 2007 Jun 25;5:Doc03
references.pmid: 19675711
references.citation: Hong Kong Med J. 2006 Apr;12(2):149-51
references.pmid: 16603783
references.citation: Am J Perinatol. 2002 May;19(4):215-9
references.pmid: 12012283
references.citation: Hum Mutat. 1999;14(6):477-84
references.pmid: 10571945
references.citation: Cell Biochem Funct. 2004 Sep-Oct;22(5):339-42
references.pmid: 15338475
references.citation: Pediatrics. 1979 Sep;64(3):321-3
references.pmid: 481976
references.citation: JAMA. 1974 Dec 2;230(9):1304-5
references.pmid: 4479604
references.citation: Pediatr Clin North Am. 2004 Aug;51(4):1087-107, xi
references.pmid: 15275990
references.citation: Blood. 2008 Jan 1;111(1):16-24
references.pmid: 18156501
references.citation: Hum Mutat. 2002 Mar;19(3):217-24
references.pmid: 11857737
references.citation: Proc Soc Exp Biol Med. 1999 Dec;222(3):274-82
references.pmid: 10601886
references.citation: Clin Chem. 1983 Apr;29(4):708-12
references.pmid: 6831704
references.citation: Br J Haematol. 1996 Jun;93(4):822-7
references.pmid: 8703811
references.citation: FEBS Lett. 1997 Aug 18;413(2):236-8
references.pmid: 9280288
references.citation: Clin Perinatol. 1990 Jun;17(2):371-9
references.pmid: 2196135
references.citation: Haematologica. 2005 Aug;90(8):1135-6
references.pmid: 16079115
references.citation: Arch Med Res. 2006 Oct;37(7):880-2
references.pmid: 16971229
references.citation: Hum Hered. 2000 May-Jun;50(3):158-61
references.pmid: 10686492
references.citation: Blood. 1985 Dec;66(6):1272-7
references.pmid: 4063520
references.citation: Int J Hematol. 2006 Feb;83(2):139-43
references.pmid: 16513531
references.citation: Blood. 1996 Aug 1;88(3):1084-8
references.pmid: 8704218
references.citation: J Pediatr. 1967 Feb;70(2):166-71
references.pmid: 5334979
references.citation: Acta Paediatr Suppl. 1994 Mar;394:58-76
references.pmid: 7919613
references.citation: J Trop Pediatr. 1986 Oct;32(5):251-4
references.pmid: 3795336
references.citation: J Paediatr Child Health. 2004 Nov;40(11):633-7
references.pmid: 15469533
references.citation: Am J Clin Nutr. 1991 Jan;53(1 Suppl):201S-205S
references.pmid: 1985388
references.citation: EXS. 1992;62:419-22
references.pmid: 1450602
references.citation: Am Fam Physician. 2005 Oct 1;72(7):1277-82
references.pmid: 16225031
references.citation: Arch Med Res. 2002 May-Jun;33(3):276-80
references.pmid: 12031634
references.citation: J Clin Pathol. 2005 Mar;58(3):317-9
references.pmid: 15735168
references.citation: Early Hum Dev. 2003 Apr;71(2):129-36
references.pmid: 12663150
references.citation: Baillieres Best Pract Res Clin Haematol. 2000 Mar;13(1):21-38
references.pmid: 10916676