Only two ways to achieve perfection.
The functional repertoire of a network is determined by its topology. Ma et al. (2009) analyze enzyme networks with three nodes and take a reverse-engineering approach to ask how many core network topologies can establish perfect adaptation, the ability to reset after perturbation. Surprisingly, the answer is just two.
Artyukhin
Alexander B
AB
Department of Pharmacology, Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Wu
Lani F
LF
Altschuler
Steven J
SJ
D000222:Adaptation, Physiological; D003198:Computer Simulation; D004798:Enzymes / Q000502:physiology; D008954:Models, Biological
D004798:Enzymes