Beating Poisson encapsulation statistics using close-packed ordering.
Loading drops with discrete objects, such as particles and cells, is often necessary when performing chemical and biological assays in microfluidic devices. However, random loading techniques are inefficient, yielding a majority of empty and unusable drops. We use deformable particles that are close packed to insert a controllable number of particles into every drop. This provides a simple, flexible means of efficiently encapsulating a controllable number of particles per drop.
Abate
Adam R
AR
School of Engineering and Applied Sciences/Department of Physics, Harvard University, Cambridge, Massachusetts, USA.
Chen
Chia-Hung
CH
Agresti
Jeremy J
JJ
Weitz
David A
DA
D003627:Data Interpretation, Statistical; D004339:Drug Compounding; D046210:Microfluidic Analytical Techniques; D044085:Microfluidics / Q000706:statistics & numerical data*; D053758:Nanoparticles; D016012:Poisson Distribution