Thyroid tumors: novel insights from proteomic studies.
Several genomics-based techniques have been applied in the last decade to the molecular characterization of cancer, which has led to a variety of applications suitable for improved diagnosis, prognosis and prediction of outcome to treatment. Proteomics-based approaches have also been seen as crucial to the discovery of biomarkers for early diagnosis and prognosis of tumors, as well as for a better understanding of the molecular bases of cancer. Accordingly, proteomic techniques have been used extensively for a better molecular characterization of thyroid tumors. In this field, three main directions have been preceded: first, proteomic studies of model systems; second, proteomics of thyroid tumor specimens; and third, serum proteomics. In this review, we describe the most relevant results that have been obtained for tumors derived from thyroid follicular cells using various proteomic approaches.
Damante
Giuseppe
G
Dipartimento di Scienze e Tecnologie Biomediche, Piazzale Kolbe 1, 33100 Udine, Italy. giuseppe.damante@uniud.it
Scaloni
Andrea
A
Tell
Gianluca
G
D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism; D006801:Humans; D040901:Proteomics / Q000379:methods*; D013964:Thyroid Neoplasms / Q000175:diagnosis / Q000378:metabolism*
D014408:Biomarkers, Tumor