Serum p53 protein and anti-p53 antibodies are associated with increased cancer risk: a case-control study of 569 patients and 879 healthy controls.
The aim of this study to determine whether serum p53 protein and antibodies are associated with malignant tumors. A case-control study was conduct in 569 patients with various types of malignant tumors and 879 healthy controls. Serum p53 protein and antibodies were analyzed by enzyme-linked immunosorbent assay (ELISA).The rate of positive p53 protein in patients with various malignant tumors was 4.22% compared with 0.34% in healthy controls (P < 0.001). The rate of anti-p53 antibodies in patients with various malignant tumors was 14.59% compared with 1.02% in healthy controls (P < 0.001). The adjusted odd ratio (OR) for p53 protein was 17.55 (95% CI = 4.98-61.94). The adjusted odd ratio for anti-p53 antibodies was 14.27 (95% CI = 6.75-30.16). The study strongly suggested that serum p53 protein and antibody are associated with increased cancer risk and can be used as early serological markers in the diagnosis of malignancies tumors.
Wu
Min
M
Department of Epidemiology, School of Public Health and Tropical Medicine, Southern Medical University, Guangdong, China.
Mao
Chen
C
Chen
Qing
Q
Cu
Xin-Wei
XW
Zhang
Wei-Seng
WS
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000912:Antibodies, Neoplasm / Q000276:immunology*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood* / Q000175:diagnosis / Q000276:immunology*; D012307:Risk Factors; D016159:Tumor Suppressor Protein p53 / Q000097:blood* / Q000276:immunology*; D055815:Young Adult
D000912:Antibodies, Neoplasm; D016159:Tumor Suppressor Protein p53
Cancer. 2003 Feb 1;97(3):682-9
12548611
Nature. 1991 Jun 6;351(6326):453-6
2046748
Int J Oncol. 2006 Oct;29(4):973-80
16964393
J Gastroenterol. 2001 Dec;36(12):830-6
11777211
Anal Quant Cytol Histol. 2000 Feb;22(1):76-9
10696464
J Gastroenterol. 2001 Dec;36(12):865-6
11777218
Br J Cancer. 1999 Feb;79(5-6):927-32
10070892
Int J Cancer. 2005 Mar 10;114(1):157-60
15523685
Int J Urol. 2004 Dec;11(12):1070-7
15663677
Br J Cancer. 1999 Aug;80(12):1987-94
10471051
Cancer Epidemiol Biomarkers Prev. 2009 Feb;18(2):417-23
19190145
J Occup Environ Med. 2006 Feb;48(2):158-64
16474264
Di Yi Jun Yi Da Xue Xue Bao. 2003 May;23(5):491-3
12754142
Cancer Res. 2000 Apr 1;60(7):1777-88
10766157
J Clin Oncol. 2006 Feb 10;24(5):762-8
16391298
Int J Oncol. 2006 Apr;28(4):995-1002
16525651
Jpn J Clin Oncol. 2009 Apr;39(4):217-24
19304743
J Radiat Res. 2005 Mar;46(1):21-4
15802855
Clin Chem Lab Med. 2006;44(5):653-6
16681440