title: Delayed gadolinium-enhanced MR imaging of articular cartilage: three-dimensional T1 mapping with variable flip angles and B1 correction.
abstract: OBJECTIVE
  To develop and verify the accuracy of a rapid imaging protocol for delayed gadolinium-enhanced magnetic resonance (MR) imaging of cartilage that was based on three-dimensional (3D) spoiled gradient-recalled acquisition in the steady state (SPGR) sequences with variable flip angles (FAs) (VFAs) and where a correction method for B(1) field inhomogeneities was applied.
  
  
  METHODS
  The institutional research ethics board approved this study. Written informed consent was obtained from all subjects. A B(1) field inhomogeneity correction method was applied to a 3D SPGR pulse sequence with VFAs (repetition time msec/echo time msec, 7.1/3.3; FAs, 2 degrees , 5 degrees , 10 degrees , and 20 degrees ) and was used to perform delayed gadolinium-enhanced MR imaging of cartilage 3D T1 measurements at 1.5 T. The 3D T1 measurements were validated with the reference standard (the results of T1 mapping by using a single-section two-dimensional [2D] inversion-recovery [IR] fast spin-echo [SE] pulse sequence in vitro and in vivo) in six healthy volunteers.
  
  
  RESULTS
  T1 values calculated from 3D T1 maps were not significantly different from reference T1 values in vitro (P = .195) and in vivo (P = .52) when a B(1) field inhomogeneity correction method was applied. In vivo T1 mapping of the articular surface of the whole femoropatellar joint, including data acquisition, was performed in approximately 8 minutes of acquisition time at a spatial resolution of 0.55 x 0.55 x 3.00 mm.
  
  
  CONCLUSIONS
  Rapid T1 mapping by using 3D SPGR acquisitions with a VFA approach and a correction for B(1) field inhomogeneities can be used for delayed gadolinium-enhanced MR imaging of cartilage. T1 measurements performed in vitro and in vivo by using this approach are highly accurate when compared with those performed by using standard 2D IR fast SE T1 mapping as a reference.
authors.affiliation: Department of Medical Imaging, Mount Sinai Hospital and the University Health Network, University of Toronto, Toronto, Ontario, Canada. gustav@andreisek.de
authors.forename: Gustav
authors.initials: G
authors.lastname: Andreisek
authors.forename: Lawrence M
authors.initials: LM
authors.lastname: White
authors.forename: Yi
authors.initials: Y
authors.lastname: Yang
authors.forename: Emma
authors.initials: E
authors.lastname: Robinson
authors.forename: Hai-Ling Margaret
authors.initials: HL
authors.lastname: Cheng
authors.forename: Marshall S
authors.initials: MS
authors.lastname: Sussman
mesh_terms: D000328:Adult; D002358:Cartilage, Articular / Q000033:anatomy & histology / Q000473:pathology*; D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D021621:Imaging, Three-Dimensional; D016014:Linear Models; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D010329:Patella / Q000033:anatomy & histology / Q000473:pathology*; D019047:Phantoms, Imaging; D018709:Statistics, Nonparametric
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA