title: Toll-like receptors in Alzheimer's disease.
abstract: Alzheimer's disease (AD) is characterized by the formation of insoluble deposits of beta-amyloid (Abeta) within the parenchyma of the brain. These deposits are associated with a robust microglia-mediated inflammatory response. Recent work has demonstrated that Toll-like receptors (TLRs) participate in this inflammatory response. This chapter reviews the mechanisms whereby TLRs contribute to the induction of a microglial inflammatory response to promote AD pathogenesis. Specifically, the involvement of CD14 and the TLRs in microglial activation is delineated. The TLR-mediated microglial response has beneficial roles in stimulating phagocytosis as well as detrimental roles in the Abeta-stimulated release of neurotoxic products.
authors.affiliation: Alzheimer Research Laboratory, Department of Neurosciences, Case Western Reserve University, Cleveland, OH 44106, USA, gel2@case.edu
authors.forename: Gary E
authors.initials: GE
authors.lastname: Landreth
authors.forename: Erin G
authors.initials: EG
authors.lastname: Reed-Geaghan
mesh_terms: D000544:Alzheimer Disease / Q000276:immunology*; D016229:Amyloid beta-Peptides / Q000276:immunology; D006801:Humans; D051193:Toll-Like Receptors / Q000276:immunology*
chemical_list: D016229:Amyloid beta-Peptides; D051193:Toll-Like Receptors
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