Well-differentiated and dedifferentiated liposarcomas.
Atypical lipomatous tumor or well-differentiated liposarcoma (ALT-WDLPS) and dedifferentiated liposarcoma (DDLPS) share the same basic genetic abnormality characterized by a simple genomic profile with a 12q14-15 amplification involving MDM2 gene. These tumors are the most frequent LPS. This paper reviews the molecular pathology, general clinical and imaging features, histopathology, new diagnostic tools, and prognosis of ALT-WDLPS and DDLPS.
Coindre
Jean-Michel
JM
Department of Pathology and INSERM U916, Institut Bergonié, Bordeaux, France. coindre@bergonie.org
Pédeutour
Florence
F
Aurias
Alain
A
D051358:Cyclin-Dependent Kinase 4 / Q000235:genetics; D005784:Gene Amplification / Q000235:genetics; D006801:Humans; D007621:Karyotyping; D008080:Liposarcoma / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D011379:Prognosis; D051736:Proto-Oncogene Proteins c-mdm2 / Q000235:genetics
C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2; D051358:Cyclin-Dependent Kinase 4
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