Turner syndrome phalangeal screening based on a two-stage linear regression concept.
BACKGROUND
Turner syndrome (TS) is a congenital chromosomal abnormality, resulting in short stature, short fourth metacarpal, and retarded skeletal maturation in children. The existing methods of diagnosis, which include carpal angle, metacarpal sign, and body mass index (BMI), cannot accurately diagnose TS. The authors propose a novel procedure for examining the hand skeleton to distinguish between normal individuals and patients with TS.


METHODS
This investigation was divided into two parts. In the first part, existing methods (evaluation of the metacarpal sign, measurement of the carpal angle, and determination of BMI) were used. Examination in the second part was based on the two-stage screening method (TSSM). In the first stage in TSSM, the ratio of the lengths of the distal-middle phalanges of the fifth digit was determined in normal subjects with average range of satisfactory body height and TS patients. A suitable cut-off was found on linear regression and used to divide the plot into TS patients and normal subjects. In the second stage, the normal section was transferred to another group based on bone and chronological ages. A greater number of patients were diagnosed with TS using this method. Finally, four cut-off parameters were determined on linear regression analysis. Results with optimal sensitivity and specificity were automatically obtained.


RESULTS
The combination of TSSM with optimal programming (sensitivity = 0.81 and specificity = 0.91) was satisfactory for diagnosing TS patients.


CONCLUSIONS
TSSM can suitably evaluate growth of the hand skeleton to distinguish between normal individuals and patients with TS.
Tiu
Chui-Mei
CM
Department of Radiology, Taipei Veterans General Hospital, Taipei, Taiwan.
Liu
Tzu-Chiang
TC
Hsieh
Chi-Wen
CW
Niu
Dau-Ming
DM
Chen
Jen-Dar
JD
Jong
Tai-Lang
TL
D002648:Child; D005385:Fingers / Q000002:abnormalities* / Q000000981:diagnostic imaging; D006225:Hand; D006801:Humans; D016014:Linear Models; D011859:Radiography; D012680:Sensitivity and Specificity; D014424:Turner Syndrome / Q000175:diagnosis*