title: Convenient solution-phase synthesis and conformational studies of novel linear and cyclic alpha,beta-alternating peptoids.
abstract: The synthesis of a novel family of peptidomimetics composed of linear and cyclic alpha,beta-alternating peptoids is described. Oligomers consisting of up to six peptoid residues (n = 1-3) were synthesized on large scale with use of an efficient iterative solution-phase method and longer oligomers (n = 4, 5) were obtained by the coupling of appropriately protected shorter oligomers. Preliminary conformational studies of these hybrid peptoids are reported.
authors.affiliation: Clermont Université, Université Blaise Pascal, Laboratoire SEESIB (UMR 6504-CNRS), 24 avenue des Landais, 63177 Aubière cedex, France.
authors.forename: Thomas
authors.initials: T
authors.lastname: Hjelmgaard
authors.forename: Sophie
authors.initials: S
authors.lastname: Faure
authors.forename: Cécile
authors.initials: C
authors.lastname: Caumes
authors.forename: Emiliana
authors.initials: E
authors.lastname: De Santis
authors.forename: Alison A
authors.initials: AA
authors.lastname: Edwards
authors.forename: Claude
authors.initials: C
authors.lastname: Taillefumier
mesh_terms: D000595:Amino Acid Sequence; D008969:Molecular Sequence Data; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000737:chemistry*; D034444:Peptoids / Q000737:chemistry*; D011487:Protein Conformation; D055672:Static Electricity
chemical_list: D010456:Peptides, Cyclic; D034444:Peptoids