Experimental and clinical pharmacokinetics of amitryptiline: comparative analysis.
Pharmacokinetics of two amitriptyline tablets, Amitryptiline Nycomed and Amitryptiline, was investigated clinically and experimentally after a single oral dose of 50 mg. A statistically significant correlation between amitryptiline serum concentrations in dogs and healthy humans (r=0.683, p<0.006) was established. In humans, standartized values of peak concentration and area under the concentration curve were significantly higher, specific volume of distribution and total clearance were lower, and half-life and mean retention time were significantly higher than in dogs. Characteristics of apparent bioavailability in dogs and healthy people did not statistically differ.
Kukes
V G
VG
Department of Clinical Pharmacology and Propedeutics of Internal Disease, I.M. Sechenov Moscow Medical Academy, Moscow.
Kondratenko
S N
SN
Savelyeva
M I
MI
Starodubtsev
A K
AK
Gneushev
E T
ET
D000328:Adult; D000639:Amitriptyline / Q000097:blood* / Q000493:pharmacokinetics*; D000818:Animals; D000928:Antidepressive Agents / Q000097:blood* / Q000493:pharmacokinetics*; D019540:Area Under Curve; D004285:Dogs; D005260:Female; D006207:Half-Life; D006801:Humans; D016014:Linear Models; D008297:Male; D013045:Species Specificity; D055815:Young Adult
D000928:Antidepressive Agents; D000639:Amitriptyline