title: HCV infection and cryptogenic cirrhosis are risk factors for hepatocellular carcinoma among Latinos in New York City.
abstract: Latinos in the US experience a 60% higher death rate from primary hepatocellular carcinoma (HCC) when compared to Non-Latinos. The goal of this study was to examine risk factors that are associated with ethnic disparities among HCC patients seen at the transplant center of a metropolitan medical center in New York City. We compared HCC risk factors in 140 Non-Latino and 55 Latino patients that presented with HCC from 1995 to 2003. Surnames were used to define Latino and Non-Latino HCC patients in a retrospective analysis. Latino and Non-Latino HCC patients did not vary by gender or age at presentation (mean Latino age 60.8). Latino HCC patients had a higher frequency of presentation with advanced disease, defined as patients with unresectable HCC, than non Latino HCC patients (Latino 52.7%; 95% CI 39.1-66.3 vs. Non-Latino vs. 36.4%; 95% CI 28.3-44.4). Latinos were more likely than Non Latinos to have underlying HCV (34.5 vs. 22.1%, P < .0001; adjusted odds ratio [Siegel, 2008 #564], 3.69; 95% CI, 1.16-11.7) and cryptogenic liver diseases (7.2 vs. 3.5%, P < .0001; OR 8.86; 95% CI, 1.21-65.0) after adjusting for age, gender and alfa-fetoprotein levels. Although more advanced disease may signal delay in access to care or more aggressive disease, HCV infection and cryptogenic cirrhosis at presentation are likely key factors for the greater burden of HCC among Latinos in New York City.
authors.affiliation: Johns Hopkins School of Medicine, Baltimore, MD 21231, USA. rguerre3@jhmi.edu
authors.forename: Rafael
authors.initials: R
authors.lastname: Guerrero-Preston
authors.forename: Abby
authors.initials: A
authors.lastname: Siegel
authors.forename: John
authors.initials: J
authors.lastname: Renz
authors.forename: David
authors.initials: D
authors.lastname: Vlahov
authors.forename: Alfred
authors.initials: A
authors.lastname: Neugut
mesh_terms: D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000208:ethnology* / Q000473:pathology / Q000821:virology; D005260:Female; D054624:Health Status Disparities; D006526:Hepatitis C / Q000150:complications / Q000208:ethnology*; D006630:Hispanic or Latino / Q000706:statistics & numerical data*; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications / Q000208:ethnology*; D008113:Liver Neoplasms / Q000208:ethnology* / Q000473:pathology / Q000821:virology; D008297:Male; D008875:Middle Aged; D009519:New York City / Q000453:epidemiology; D012189:Retrospective Studies; D012307:Risk Factors
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