Oxidative stress and DNA damage in older adults that do exercises regularly.
OBJECTIVE
Free radicals may damage lipids, proteins and DNA, which may lead to critical diseases in the aging. This work evaluated levels of malondialdehyde (MDA), glutathione peroxidase (GPx) and DNA damage by comet assay (SCGE) in older adults that do exercises regularly.


METHODS
110 females, aged 66.3+/-8 years were divided into sedentary (n=54), walking (n=36) and muscle building (n=20) groups. Levels of MDA, GPx and SCGE were measured in venous blood before and after exercise.


RESULTS
MDA levels were higher (P<0.005) and GPx levels were lower (P<0.005) in active groups than in sedentary group. SCGE index after physical activity was greater than at baseline (muscle building: P=0.004; walking: P=0.002).


CONCLUSIONS
Exercise reduces the diseases risk, but may promote the production of free radicals. It remains unclear whether cell adaptations responsible for health benefits are associated with such events. However we may suggest the existence of a different biochemical pattern for older adults that do exercise regularly.
Mergener
Michelle
M
Biological and Health Center, UNIVATES, Lajeado-RS, Brazil.
Martins
Maclóvia Rosso
MR
Antunes
Marina Venzon
MV
da Silva
Caroline Calice
CC
Lazzaretti
Camilla
C
Fontanive
Tiago Oselane
TO
Suyenaga
Edna Sayuri
ES
Ardenghi
Patrícia Grolli
PG
Maluf
Sharbel Weidner
SW
Gamaro
Giovana Duzzo
GD
D000368:Aged; D020552:Comet Assay; D004249:DNA Damage; D015444:Exercise; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism; D006801:Humans; D008315:Malondialdehyde / Q000378:metabolism; D008875:Middle Aged; D018384:Oxidative Stress
D008315:Malondialdehyde; D005979:Glutathione Peroxidase