title: Searching for MIND: microRNAs in neurodegenerative diseases.
abstract: In few years our understanding of microRNA (miRNA) biogenesis, molecular mechanisms by which miRNAs regulate gene expression, and the functional roles of miRNAs has been expanded. Interestingly, numerous miRNAs are expressed in a spatially and temporally controlled manner in the nervous system, suggesting that their posttrascriptional regulation may be particularly relevant in neural development and function. MiRNA studies in neurobiology showed their involvement in synaptic plasticity and brain diseases. In this review ,correlations between miRNA-mediated gene silencing and Alzheimer's, Parkinson's, and other neurodegenerative diseases will be discussed. Molecular and cellular neurobiological studies of the miRNAs in neurodegeneration represent the exploration of a new Frontier of miRNAs biology and the potential development of new diagnostic tests and genetic therapies for neurodegenerative diseases.
authors.affiliation: European Brain Research Institute (EBRI), Fondazione EBRI- Rita Levi-Montalcini, Roma, Italy. c.barbato@inmm.cnr.it
authors.forename: Christian
authors.initials: C
authors.lastname: Barbato
authors.forename: Francesca
authors.initials: F
authors.lastname: Ruberti
authors.forename: Carlo
authors.initials: C
authors.lastname: Cogoni
mesh_terms: D000818:Animals; D020868:Gene Silencing; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D019636:Neurodegenerative Diseases / Q000235:genetics*
chemical_list: D035683:MicroRNAs
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