title: Neurocognitive characteristics of individuals with schizophrenia and cocaine dependence: comparison of currently dependent and remitted groups.
abstract: Several investigations of cognitive functioning in individuals with schizophrenia and co-occurring cocaine use have yielded mixed results when compared with samples with schizophrenia only. However, no studies have specifically compared remitted and current cocaine dependence in schizophrenia. Such an analysis could help clarify the degree and type of cognitive impairment associated with cocaine dependence in schizophrenia. Two samples of individuals with schizophrenia - those with current cocaine dependence (n = 72) and those with cocaine dependence in remission (n = 48) were compared on a brief neuropsychological test battery. Parallel current dependent and remitted samples with affective disorder (n = 65 and n = 55) were also included in the analyses. Results yielded few neuropsychological differences between remitted and current dependent states across the SZ and AD groups. These findings suggest that cognitive impairment may be relatively static in these populations.
authors.affiliation: Veterans Affairs Capitol Health Care Network Mental Illness, Research, Education, and Clinical Center, Baltimore, MD, USA. jason.peer@va.gov
authors.forename: Jason
authors.initials: J
authors.lastname: Peer
authors.forename: Melanie E
authors.initials: ME
authors.lastname: Bennett
authors.forename: Alan S
authors.initials: AS
authors.lastname: Bellack
mesh_terms: D000328:Adult; D019970:Cocaine-Related Disorders / Q000175:diagnosis* / Q000453:epidemiology / Q000523:psychology; D003072:Cognition Disorders / Q000175:diagnosis* / Q000453:epidemiology / Q000523:psychology; D015897:Comorbidity; D017831:Diagnosis, Dual (Psychiatry); D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D009483:Neuropsychological Tests / Q000706:statistics & numerical data*; D011569:Psychiatric Status Rating Scales; D011594:Psychometrics; D012559:Schizophrenia / Q000175:diagnosis* / Q000453:epidemiology; D012565:Schizophrenic Psychology; D012720:Severity of Illness Index
references.citation: J Subst Abuse Treat. 2003 Jan;24(1):75-9
references.pmid: 12646333
references.citation: Schizophr Res. 1999 Mar 1;35 Suppl:S93-100
references.pmid: 10190230
references.citation: Drug Alcohol Depend. 1999 Mar 1;54(1):19-33
references.pmid: 10101614
references.citation: Schizophr Res. 2008 Mar;100(1-3):242-51
references.pmid: 17614260
references.citation: JAMA. 1990 Nov 21;264(19):2511-8
references.pmid: 2232018
references.citation: Schizophr Bull. 1990;16(1):31-56
references.pmid: 2333480
references.citation: Psychiatr Serv. 2006 Aug;57(8):1110-6
references.pmid: 16870961
references.citation: Arch Gen Psychiatry. 1997 Feb;54(2):159-65
references.pmid: 9040284
references.citation: Drug Alcohol Depend. 2002 Apr 1;66(2):161-71
references.pmid: 11906803
references.citation: J Subst Abuse Treat. 1992;9(3):199-213
references.pmid: 1334156
references.citation: Am J Psychiatry. 1993 Sep;150(9):1355-62
references.pmid: 8352346
references.citation: J Nerv Ment Dis. 2002 Mar;190(3):200-2
references.pmid: 11923656
references.citation: Biol Psychiatry. 2007 Jul 15;62(2):179-86
references.pmid: 17161829
references.citation: Psychiatry Res. 2004 Oct 30;128(3):209-18
references.pmid: 15541777
references.citation: Addict Behav. 2008 Aug;33(8):1021-30
references.pmid: 18485611
references.citation: Addiction. 1997 Jun;92(6):747-59
references.pmid: 9246802
references.citation: Am J Psychiatry. 1993 May;150(5):758-62
references.pmid: 8480822
references.citation: Curr Opin Neurobiol. 2001 Apr;11(2):250-7
references.pmid: 11301247
references.citation: Psychiatry Res. 2000 Feb 14;93(1):21-32
references.pmid: 10699225
references.citation: J Nerv Ment Dis. 2003 May;191(5):300-8
references.pmid: 12819549
references.citation: J Nerv Ment Dis. 1990 Oct;178(10):642-8
references.pmid: 2230749
references.citation: J Subst Abuse. 2000;11(2):205-13
references.pmid: 10989779