title: Oxidative stress and DNA damage in older adults that do exercises regularly.
abstract: OBJECTIVE
  Free radicals may damage lipids, proteins and DNA, which may lead to critical diseases in the aging. This work evaluated levels of malondialdehyde (MDA), glutathione peroxidase (GPx) and DNA damage by comet assay (SCGE) in older adults that do exercises regularly.
  
  
  METHODS
  110 females, aged 66.3+/-8 years were divided into sedentary (n=54), walking (n=36) and muscle building (n=20) groups. Levels of MDA, GPx and SCGE were measured in venous blood before and after exercise.
  
  
  RESULTS
  MDA levels were higher (P<0.005) and GPx levels were lower (P<0.005) in active groups than in sedentary group. SCGE index after physical activity was greater than at baseline (muscle building: P=0.004; walking: P=0.002).
  
  
  CONCLUSIONS
  Exercise reduces the diseases risk, but may promote the production of free radicals. It remains unclear whether cell adaptations responsible for health benefits are associated with such events. However we may suggest the existence of a different biochemical pattern for older adults that do exercise regularly.
authors.affiliation: Biological and Health Center, UNIVATES, Lajeado-RS, Brazil.
authors.forename: Michelle
authors.initials: M
authors.lastname: Mergener
authors.forename: Maclóvia Rosso
authors.initials: MR
authors.lastname: Martins
authors.forename: Marina Venzon
authors.initials: MV
authors.lastname: Antunes
authors.forename: Caroline Calice
authors.initials: CC
authors.lastname: da Silva
authors.forename: Camilla
authors.initials: C
authors.lastname: Lazzaretti
authors.forename: Tiago Oselane
authors.initials: TO
authors.lastname: Fontanive
authors.forename: Edna Sayuri
authors.initials: ES
authors.lastname: Suyenaga
authors.forename: Patrícia Grolli
authors.initials: PG
authors.lastname: Ardenghi
authors.forename: Sharbel Weidner
authors.initials: SW
authors.lastname: Maluf
authors.forename: Giovana Duzzo
authors.initials: GD
authors.lastname: Gamaro
mesh_terms: D000368:Aged; D020552:Comet Assay; D004249:DNA Damage; D015444:Exercise; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism; D006801:Humans; D008315:Malondialdehyde / Q000378:metabolism; D008875:Middle Aged; D018384:Oxidative Stress
chemical_list: D008315:Malondialdehyde; D005979:Glutathione Peroxidase