[An empirical study of treating chronic sinusitis with low dose Roxithromycin].
OBJECTIVE
Observe the therapeutic effect of low dose Roxithromycin in treating chronic sinusitis and further discuss the mechanism of Roxithromycin facile endothelial cell apoptosis.


METHODS
All 47 patients who suffer chronic sinusitis at out-patient clinic from 2006. 10 to 2008. 03 were administered low dose Roxithromycin. Follow up all the patients and get polypi at 3-month and 6-month. AO/EB was employed to detect the apoptosis of endothelial cell.


RESULTS
At 3-month and 6-month the improvement of ventilation are 37.25 +/- 12.21, 63.15 +/- 22.78; Decrease of nasal discharge are 42.12 +/- 13.56, 74.45 +/- 28.79; alleviation of headache are 18.98 +/- 7. 66, 34.47 +/- 14.11; Improvement of olfactory are 21.23 +/- 8.41, 38.18 +/- 16.54; Apoptotic index are (39.54 +/- 6.86)% and (62.34 +/- 8.67)%, which are significantly different (P<0.05).


CONCLUSIONS
Low dose Roxithromycin has good long term curative effect in treating chronic sinusitis. Low dose Roxithromycin can greatly urge the apoptosis of endothelial cell.
Song
Yan
Y
Department of Otolaryngology, Shengjing Hospital, China Medical University, Shenyang, 110004, China. songyl@sj-hospital.org
Bai
Weiliang
W
Ji
Wenyue
W
D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D017209:Apoptosis; D002648:Child; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000150:complications / Q000188:drug therapy*; D015575:Roxithromycin / Q000008:administration & dosage / Q000627:therapeutic use*; D012852:Sinusitis / Q000150:complications / Q000188:drug therapy*; D055815:Young Adult
D000900:Anti-Bacterial Agents; D015575:Roxithromycin