Anthracycline extravasation: a comprehensive review of experimental and clinical treatments.
An accidental extravasation of anthracycline-containing chemotherapy is a feared complication that may lead to necrosis and severe tissue destruction. For four decades, much effort has been done to prevent and treat this devastating condition. Savene has recently been proved to be very effective, and is the only approved treatment against anthracyline extravasation. It is thus now widely recommended. The present article represents a comprehensive review of, and historical insight to, the experimental and clinical studies of surgical and non-surgical treatments of extravasation during forty years of clinical anthracycline treatment.
Langer
Seppo W
SW
Department of Oncology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. seppo.langer@rh.regionh.dk
Sehested
Maxwell
M
Jensen
Peter Buhl
PB
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000818:Animals; D018943:Anthracyclines / Q000008:administration & dosage / Q000009:adverse effects*; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects*; D001639:Bicarbonates / Q000627:therapeutic use; D004121:Dimethyl Sulfoxide / Q000627:therapeutic use; D005119:Extravasation of Diagnostic and Therapeutic Materials / Q000188:drug therapy / Q000209:etiology / Q000601:surgery / Q000628:therapy*; D016222:Fibroblast Growth Factor 2 / Q000627:therapeutic use; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000627:therapeutic use; D006801:Humans; D006821:Hyaluronoglucosaminidase / Q000627:therapeutic use; D009336:Necrosis / Q000139:chemically induced / Q000628:therapy; D011929:Razoxane / Q000627:therapeutic use; D012871:Skin Diseases / Q000139:chemically induced* / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D014456:Ulcer / Q000139:chemically induced / Q000628:therapy; D024502:alpha-Tocopherol / Q000627:therapeutic use
D000305:Adrenal Cortex Hormones; D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic; D001639:Bicarbonates; D016222:Fibroblast Growth Factor 2; D016179:Granulocyte Colony-Stimulating Factor; D011929:Razoxane; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D006821:Hyaluronoglucosaminidase; D024502:alpha-Tocopherol; D004121:Dimethyl Sulfoxide