Adaptive designs for Phase I dose-finding studies.
Improving methodology for Phase I dose-finding studies is currently of great interest in pharmaceutical and medical research. This article discusses the current atmosphere and attitude towards adaptive designs and focuses on the influence of Bayesian approaches.
Zhou
Yinghui
Y
The University of Reading, Berkshire, UK. y.zhou@reading.ac.uk <y.zhou@reading.ac.uk>
D000465:Algorithms; D000818:Animals; D001499:Bayes Theorem; D017321:Clinical Trials, Phase I as Topic / Q000379:methods*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D012107:Research Design
D004364:Pharmaceutical Preparations