title: [Development of neointimal matrix after incorporation of modern alloplastic prostheses: comparison between ePTFE and Dacron].
abstract: BACKGROUND
  In the therapy for peripheral arterial occlusive disease there remain inadequacies in the use of alloplastic material concerning thrombogenicity and biological compliance. In the 1960s, Sparks tried to combine the advantages of alloplastic prostheses with those of autologous reconstructions by using incorporated prostheses. No extensive myointimal hyperplasia was noted, but besides infections aneurysmatic dilatation were limiting factors in clinical practice.
  
  
  METHODS
  The incorporation of modern alloplastic prostheses without connection to circulation concerning the thickness of neointima as well as the percentage of smooth muscle cells was examined in a dog model.
  
  
  RESULTS
  The thickness of the neointima increased significantly in Dacron grafts with a peak on day 70 (p = 0.022), additionally a significantly greater percentage of smooth muscle cells was noted in Dacron grafts after 44 and 58 days (p = 0.008, p = 0.036).
  
  
  CONCLUSIONS
  Due to the decreased thickness of the incorporating matrix as well as the lower percentage of smooth muscle cells, PTFE grafts should be preferred for peripheral arterial revascularisation.
authors.affiliation: Universitätsklinikum Düsseldorf, Klinik für Gefässchirurgie und Nierentransplantation, Düsseldorf, Deutschland.
authors.forename: A
authors.initials: A
authors.lastname: Sagban
authors.forename: E
authors.initials: E
authors.lastname: Schiegel
authors.forename: T
authors.initials: T
authors.lastname: Pfeiffer
authors.forename: D
authors.initials: D
authors.lastname: Grotemeyer
authors.forename: P
authors.initials: P
authors.lastname: Reinecke
authors.forename: W
authors.initials: W
authors.lastname: Sandmann
authors.forename: K M
authors.initials: KM
authors.lastname: Balzer
mesh_terms: D000199:Actins / Q000032:analysis; D000818:Animals; D001807:Blood Vessel Prosthesis; D002196:Capillaries / Q000473:pathology; D003238:Connective Tissue / Q000473:pathology; D004285:Dogs; D005352:Fibromuscular Dysplasia / Q000473:pathology; D008856:Microscopy, Fluorescence; D011093:Polyethylene Terephthalates; D011138:Polytetrafluoroethylene; D017539:Tunica Intima / Q000473:pathology*; D014945:Wound Healing / Q000502:physiology*
chemical_list: C541116:ACTA2 protein, human; D000199:Actins; D011093:Polyethylene Terephthalates; D011138:Polytetrafluoroethylene