title: Antitumoractive endoperoxides from triterpenes.
abstract: A series of triterpene endoperoxides was synthesized and screened for antitumor activity in a panel of 15 human cancer cell lines by a sulforhodamine-B (SRB) assay. The compounds induce apoptosis and show excellent antitumor activity.
authors.affiliation: Martin-Luther-Universität Halle-Wittenberg, Organische Chemie, Halle (Saale), Germany.
authors.forename: Anja
authors.initials: A
authors.lastname: Niesen
authors.forename: Alexander
authors.initials: A
authors.lastname: Barthel
authors.forename: Ralph
authors.initials: R
authors.lastname: Kluge
authors.forename: Alexander
authors.initials: A
authors.lastname: Köwitzsch
authors.forename: Dieter
authors.initials: D
authors.lastname: Ströhl
authors.forename: Stefan
authors.initials: S
authors.lastname: Schwarz
authors.forename: René
authors.initials: R
authors.lastname: Csuk
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D010545:Peroxides / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014315:Triterpenes / Q000138:chemical synthesis / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D010545:Peroxides; D014315:Triterpenes