title: Micrometastases or isolated tumor cells and the outcome of breast cancer.
abstract: BACKGROUND
  The association of isolated tumor cells and micrometastases in regional lymph nodes with the clinical outcome of breast cancer is unclear.
  
  
  METHODS
  We identified all patients in The Netherlands who underwent a sentinel-node biopsy for breast cancer before 2006 and had breast cancer with favorable primary-tumor characteristics and isolated tumor cells or micrometastases in the regional lymph nodes. Patients with node-negative disease were randomly selected from the years 2000 and 2001. The primary end point was disease-free survival.
  
  
  RESULTS
  We identified 856 patients with node-negative disease who had not received systemic adjuvant therapy (the node-negative, no-adjuvant-therapy cohort), 856 patients with isolated tumor cells or micrometastases who had not received systemic adjuvant therapy (the node-positive, no-adjuvant-therapy cohort), and 995 patients with isolated tumor cells or micrometastases who had received such treatment (the node-positive, adjuvant-therapy cohort). The median follow-up was 5.1 years. The adjusted hazard ratio for disease events among patients with isolated tumor cells who did not receive systemic therapy, as compared with women with node-negative disease, was 1.50 (95% confidence interval [CI], 1.15 to 1.94); among patients with micrometastases, the adjusted hazard ratio was 1.56 (95% CI, 1.15 to 2.13). Among patients with isolated tumor cells or micrometastases, the adjusted hazard ratio was 0.57 (95% CI, 0.45 to 0.73) in the node-positive, adjuvant-therapy cohort, as compared with the node-positive, no-adjuvant-therapy cohort.
  
  
  CONCLUSIONS
  Isolated tumor cells or micrometastases in regional lymph nodes were associated with a reduced 5-year rate of disease-free survival among women with favorable early-stage breast cancer who did not receive adjuvant therapy. In patients with isolated tumor cells or micrometastases who received adjuvant therapy, disease-free survival was improved.
authors.affiliation: Division of Medical Oncology, Maastricht University Medical Center, Maastricht, The Netherlands.
authors.forename: Maaike
authors.initials: M
authors.lastname: de Boer
authors.forename: Carolien H M
authors.initials: CH
authors.lastname: van Deurzen
authors.forename: Jos A A M
authors.initials: JA
authors.lastname: van Dijck
authors.forename: George F
authors.initials: GF
authors.lastname: Borm
authors.forename: Paul J
authors.initials: PJ
authors.lastname: van Diest
authors.forename: Eddy M M
authors.initials: EM
authors.lastname: Adang
authors.forename: Johan W R
authors.initials: JW
authors.lastname: Nortier
authors.forename: Emiel J T
authors.initials: EJ
authors.lastname: Rutgers
authors.forename: Caroline
authors.initials: C
authors.lastname: Seynaeve
authors.forename: Marian B E
authors.initials: MB
authors.lastname: Menke-Pluymers
authors.forename: Peter
authors.initials: P
authors.lastname: Bult
authors.forename: Vivianne C G
authors.initials: VC
authors.lastname: Tjan-Heijnen
mesh_terms: D000328:Adult; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D001365:Axilla; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology* / Q000601:surgery; D016022:Case-Control Studies; D017024:Chemotherapy, Adjuvant; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis / Q000473:pathology*; D008875:Middle Aged; D009367:Neoplasm Staging; D021701:Sentinel Lymph Node Biopsy; D016896:Treatment Outcome