Sequence polymorphism and evolution of three cetacean MHC genes.
Sequence variability at three major histocompatibility complex (MHC) genes (DQB, DRA, and MHC-I) of cetaceans was investigated in order to get an overall understanding of cetacean MHC evolution. Little sequence variation was detected at the DRA locus, while extensive and considerable variability were found at the MHC-I and DQB loci. Phylogenetic reconstruction and sequence comparison revealed extensive sharing of identical MHC alleles among different species at the three MHC loci examined. Comparisons of phylogenetic trees for these MHC loci with the trees reconstructed only based on non-PBR sites revealed that allelic similarity/identity possibly reflected common ancestry and were not due to adaptive convergence. At the same time, trans-species evolution was also evidenced that the allelic diversity of the three MHC loci clearly pre-dated species divergence events according to the relaxed molecular clock. It may be the forces of balancing selection acting to maintain the high sequence variability and identical alleles in trans-specific manner at the MHC-I and DQB loci.
Xu
Shi Xia
SX
Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing 210046, China.
Ren
Wen Hua
WH
Li
Shu Zhen
SZ
Wei
Fu Wen
FW
Zhou
Kai Ya
KY
Yang
Guang
G
D000483:Alleles; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002591:Cetacea / Q000235:genetics*; D019143:Evolution, Molecular; D006649:Histocompatibility Antigens / Q000737:chemistry / Q000235:genetics; D016013:Likelihood Functions; D008285:Major Histocompatibility Complex / Q000235:genetics*; D008957:Models, Genetic; D008969:Molecular Sequence Data; D021141:Nucleic Acid Amplification Techniques; D010802:Phylogeny; D011110:Polymorphism, Genetic; D012641:Selection, Genetic
D006649:Histocompatibility Antigens
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