Treatment of short stature and growth hormone deficiency in children with somatotropin (rDNA origin).
Somatotropin (growth hormone, GH) of recombinant DNA origin has provided a readily available and safe drug that has greatly improved management of children and adolescents with GH deficiency (GHD) and other disorders of growth. In the US and Europe, regulatory agencies have given approval for the use of GH in children and adults who meet specific criteria. However, clinical and ethical controversies remain regarding the diagnosis of GHD, dosing of GH, duration of therapy and expected outcomes. Areas which also require consensus include management of pubertal patients, transitioning pediatric patients to adulthood, management of children with idiopathic short stature and the role of recombinant IGF-1 in treatment. Additionally, studies have demonstrated anabolic benefits of GH in children who have inflammatory-based underlying disease and efficacy of GH in overcoming growth delays in people treated chronically with corticosteroids. These areas are open for possible new uses of this drug. This review summarizes current indications for GH use in children and discusses areas of clinical debate and potential anabolic uses in chronic illness.
Hardin
Dana S
DS
Ohio State University and Columbus Children's Hospital, Columbus, Ohio, USA.
AIDS. 2000 Apr 14;14(6):683-90
10807191
Paediatr Drugs. 2004;6(2):93-106
15035650
J Clin Endocrinol Metab. 1995 Aug;80(8):2298-301
7629222
Pediatr Res. 2005 Feb;57(2):216-22
15585685
J Clin Endocrinol Metab. 1994 Mar;78(3):744-52
8126152
Pediatrics. 2001 Nov;108(5):E92
11694676
J Pediatr. 1994 Jul;125(1):29-35
8021781
Pediatrics. 1998 Aug;102(2 Pt 3):527-30
9685459
Horm Res. 2004;62 Suppl 1:59-65
15761234
J Clin Endocrinol Metab. 2001 May;86(5):1936-41
11344188
J Clin Endocrinol Metab. 2000 Nov;85(11):3990-3
11095419
J Indian Soc Pedod Prev Dent. 2007 Jul-Sep;25(3):144-7
17951933
J Clin Endocrinol Metab. 1998 Aug;83(8):2824-9
9709954
Acta Paediatr Suppl. 1999 Dec;88(433):109-11
10626558
Horm Res. 1997;48 Suppl 5:16-20
9434040
J Clin Endocrinol Metab. 1996 May;81(5):1704-10
8626820
Clin Endocrinol (Oxf). 2007 Jan;66(1):85-94
17201806
J Bone Miner Res. 1999 Oct;14(10):1680-90
10491215
J Clin Endocrinol Metab. 2002 Mar;87(3):1088-93
11889170
J Clin Endocrinol Metab. 1996 Aug;81(8):3077-83
8768878
J Clin Endocrinol Metab. 2000 Jul;85(7):2439-45
10902791
J Pediatr. 2000 Oct;137(4):455-9
11035820
Pediatr Nephrol. 2000 Jul;14(7):701-6
10912546
J Clin Endocrinol Metab. 2003 May;88(5):2206-12
12727976
J Pediatr. 1998 Feb;132(2):319-24
9506648
J Pediatr Endocrinol. 1994 Jan-Mar;7(1):1-12
8186819
J Clin Endocrinol Metab. 2005 Sep;90(9):5247-53
15998780
J Nutr. 2000 Oct;130(10):2498-502
11015480
J Pediatr. 2005 Mar;146(3):324-8
15756212
J Pediatr. 1994 Mar;124(3):374-82
8120705
J Clin Endocrinol Metab. 1999 Dec;84(12):4607-12
10599727
J Pediatr. 1999 Feb;134(2):215-21
9931532
J Pediatr. 2004 May;144(5):648-52
15127004
Eur J Endocrinol. 2005 Feb;152(2):165-70
15745921
Horm Res. 2003;60(Suppl 1):52-7
12955018
J Pediatr. 2001 Nov;139(5):636-42
11713439
J Pediatr Endocrinol Metab. 2003 May;16 Suppl 3:619-24
12795363
J Pediatr Endocrinol Metab. 2004 Sep;17 Suppl 4:1297-306
15506076
J Clin Endocrinol Metab. 2002 Apr;87(4):1581-5
11932286
Eur J Pediatr. 1992 Aug;151(8):601-7
1380459
J Clin Endocrinol Metab. 2000 Oct;85(10):3653-60
11061518
Clin Endocrinol (Oxf). 2003 Jul;59(1):12-21
12807497
J Pediatr Endocrinol Metab. 1999 Sep-Oct;12(5):611-22
10703532
J Clin Endocrinol Metab. 2007 Sep;92(9):3406-16
17595258
J Clin Endocrinol Metab. 1996 May;81(5):1806-9
8626839
Eur J Pediatr. 2001 Jun;160(6):359-63
11421415
Clin Endocrinol (Oxf). 2005 Sep;63(3):259-62
16117811
Horm Res. 2003;60(6):291-6
14646407
Pediatr Res. 1995 Aug;38(2):267-71
7478827
Trends Endocrinol Metab. 2004 Jan-Feb;15(1):12-20
14693421
J Clin Endocrinol Metab. 2006 Dec;91(12):4925-9
17018651
N Engl J Med. 2000 Sep 28;343(13):923-30
11006368
N Engl J Med. 1999 Feb 18;340(7):502-7
10021470
Eur J Endocrinol. 2005 Jan;152(1):67-75
15762189
J Pediatr. 2004 Jan;144(1):129-31
14722532
Arch Pediatr Adolesc Med. 1995 May;149(5):497-502
7735401
J Clin Endocrinol Metab. 2003 Dec;88(12):5753-8
14671164
J Pediatr Endocrinol Metab. 2001 Sep-Oct;14(8):1097-105
11592566
J Clin Endocrinol Metab. 2001 May;86(5):1868-70
11344173
Arch Dis Child. 2001 May;84(5):440-3
11316696
Endocr Rev. 2001 Aug;22(4):425-50
11493578
J Pediatr Endocrinol Metab. 2000 Sep;13 Suppl 2:1035-44
11086659
J Clin Endocrinol Metab. 2005 Sep;90(9):5156-60
15956085
J Am Soc Nephrol. 2001 Jun;12(6):1297-1306
11373355
J Clin Endocrinol Metab. 2004 Jul;89(7):3140-8
15240584
Pediatrics. 2003 Jun;111(6 Pt 1):1253-61
12777538
Metabolism. 2002 Jan;51(1):127-35
11782884
Arch Pediatr Adolesc Med. 2002 Mar;156(3):230-40
11876666
J Pediatr. 2003 Oct;143(4):415-21
14571209
Clin Endocrinol (Oxf). 2003 Dec;59(6):779-87
14974922
Horm Metab Res. 1998 Oct;30(10):636-41
9851673
J Pediatr. 2004 Apr;144(4):430-6
15069388
J Clin Endocrinol Metab. 2003 Nov;88(11):5273-80
14602761
J Am Coll Nutr. 1998 Oct;17(5):419-24
9791837
Gastroenterology. 2003 Feb;124(2):293-302
12557135
J Clin Endocrinol Metab. 2003 Aug;88(8):3584-90
12915640
Treat Endocrinol. 2003;2(3):165-72
15966565
J Pediatr. 2004 Dec;145(6):744-9
15580194
J Clin Endocrinol Metab. 2005 Jun;90(6):3168-73
15769991
Horm Res. 2005;63(1):33-9
15604598
Pediatrics. 2007 Jun;119(6):e1230-8
17545356