title: Rho family GTPases and their regulators in lymphocytes.
abstract: Rho family GTPases, and the proteins that regulate them, have important roles in many cellular processes, including cell division, survival, migration and adhesion. Although most of our understanding of these proteins has come from studies using cell lines, more recent gene targeting studies in mice are providing insights into the in vivo function of these proteins. Here we review recent progress revealing crucial roles for these proteins in lymphocyte development, activation, differentiation and migration. The emerging picture shows that Rho family GTPases transduce signals from receptors for antigens, chemokines and cytokines, as well as adhesion molecules and pattern recognition receptors, and that they function as focal points for crosstalk between different signalling pathways.
authors.affiliation: Division of Immune Cell Biology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK. vtybule@nimr.mrc.ac.uk
authors.forename: Victor L J
authors.initials: VL
authors.lastname: Tybulewicz
authors.forename: Robert B
authors.initials: RB
authors.lastname: Henderson
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000201:enzymology / Q000276:immunology*; D002465:Cell Movement / Q000276:immunology; D003599:Cytoskeleton / Q000276:immunology / Q000378:metabolism; D006801:Humans; D016023:Integrins / Q000276:immunology / Q000378:metabolism; D051379:Mice; D010802:Phylogeny; D043562:Receptors, G-Protein-Coupled / Q000276:immunology / Q000378:metabolism; D015398:Signal Transduction / Q000276:immunology; D013601:T-Lymphocytes / Q000201:enzymology / Q000276:immunology*; D020741:rho GTP-Binding Proteins / Q000096:biosynthesis* / Q000145:classification*
chemical_list: D016023:Integrins; D043562:Receptors, G-Protein-Coupled; D020741:rho GTP-Binding Proteins
references.citation: J Biol Chem. 2003 Oct 31;278(44):43541-9
references.pmid: 12923183
references.citation: Genes Dev. 2005 Sep 1;19(17):1974-9
references.pmid: 16107613
references.citation: Immunity. 2000 Feb;12(2):151-60
references.pmid: 10714681
references.citation: Nat Immunol. 2007 Oct;8(10):1067-75
references.pmid: 17767160
references.citation: Nat Rev Mol Cell Biol. 2008 Sep;9(9):690-701
references.pmid: 18719708
references.citation: Nat Immunol. 2009 Feb;10(2):185-94
references.pmid: 19136961
references.citation: J Cell Biol. 2001 Oct 29;155(3):331-8
references.pmid: 11684704
references.citation: Nat Immunol. 2004 Mar;5(3):272-9
references.pmid: 14758359
references.citation: J Exp Med. 2008 Apr 14;205(4):853-68
references.pmid: 18362175
references.citation: Mol Cell Biol. 1997 Mar;17(3):1346-53
references.pmid: 9032261
references.citation: J Exp Med. 2005 Aug 1;202(3):371-7
references.pmid: 16061726
references.citation: J Immunol. 2004 Sep 1;173(5):3209-14
references.pmid: 15322182
references.citation: J Immunol. 2002 Apr 1;168(7):3376-86
references.pmid: 11907095
references.citation: Immunity. 2003 Mar;18(3):403-14
references.pmid: 12648457
references.citation: J Biol Chem. 2004 Apr 30;279(18):18239-46
references.pmid: 14764585
references.citation: Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):3035-40
references.pmid: 10077632
references.citation: Blood. 2007 Mar 15;109(6):2346-55
references.pmid: 17119112
references.citation: Immunol Cell Biol. 2002 Jun;80(3):231-40
references.pmid: 12067410
references.citation: Nat Immunol. 2006 Aug;7(8):827-34
references.pmid: 16845395
references.citation: Science. 2003 Oct 17;302(5644):459-62
references.pmid: 14564011
references.citation: Nat Immunol. 2004 Sep;5(9):961-7
references.pmid: 15300248
references.citation: J Cell Biol. 2006 Aug 28;174(5):647-52
references.pmid: 16943182
references.citation: Eur J Immunol. 1999 May;29(5):1709-18
references.pmid: 10359126
references.citation: J Exp Med. 2002 May 6;195(9):1115-27
references.pmid: 11994417
references.citation: Science. 2007 Jan 5;315(5808):107-11
references.pmid: 17204652
references.citation: Blood. 2006 Oct 1;108(7):2150-8
references.pmid: 16772603
references.citation: Nat Immunol. 2006 Nov;7(11):1143-9
references.pmid: 17053799
references.citation: Immunity. 2003 Jul;19(1):119-29
references.pmid: 12871644
references.citation: J Immunol. 2006 Dec 15;177(12):8620-5
references.pmid: 17142761
references.citation: Immunol Rev. 2007 Aug;218:65-81
references.pmid: 17624944
references.citation: J Biol Chem. 2000 Jan 21;275(3):2185-90
references.pmid: 10636924
references.citation: Nature. 1992 Mar 5;356(6364):68-71
references.pmid: 1311423
references.citation: Science. 2000 Jun 23;288(5474):2219-22
references.pmid: 10864872
references.citation: Curr Biol. 1998 May 7;8(10):554-62
references.pmid: 9601639
references.citation: Oncogene. 1997 Jul 31;15(5):601-5
references.pmid: 9247314
references.citation: J Immunol. 2000 Apr 15;164(8):3971-81
references.pmid: 10754287
references.citation: Mol Cell. 2005 Jan 21;17(2):205-14
references.pmid: 15664190
references.citation: J Exp Med. 2001 Oct 1;194(7):903-14
references.pmid: 11581313
references.citation: Immunol Rev. 2003 Apr;192:42-52
references.pmid: 12670394
references.citation: Biochem J. 2007 Jun 15;404(3):487-97
references.pmid: 17355222
references.citation: J Exp Med. 2007 Mar 19;204(3):497-510
references.pmid: 17325199
references.citation: J Exp Med. 1998 Dec 7;188(11):2099-111
references.pmid: 9841924
references.citation: Immunity. 1997 Oct;7(4):451-60
references.pmid: 9354466
references.citation: Curr Opin Immunol. 2005 Jun;17(3):267-74
references.pmid: 15886116
references.citation: Biochem J. 2006 Jul 1;397(1):213-22
references.pmid: 16515536
references.citation: J Cell Biol. 2002 Apr 15;157(2):253-63
references.pmid: 11956228
references.citation: EMBO J. 1997 May 1;16(9):2397-407
references.pmid: 9171353
references.citation: FEBS Lett. 2007 Sep 4;581(22):4309-17
references.pmid: 17716670
references.citation: Proc Natl Acad Sci U S A. 2000 Aug 29;97(18):10150-5
references.pmid: 10963677
references.citation: J Biol Chem. 2006 Oct 27;281(43):32385-94
references.pmid: 16905544
references.citation: Nat Immunol. 2005 Jun;6(6):608-17
references.pmid: 15864311
references.citation: Mol Biol Evol. 2007 Jan;24(1):203-16
references.pmid: 17035353
references.citation: Blood. 2005 Oct 1;106(7):2391-8
references.pmid: 15941910
references.citation: Mol Cell Biol. 2009 Apr;29(7):1796-813
references.pmid: 19158271
references.citation: Nature. 1995 Mar 30;374(6521):474-7
references.pmid: 7700360
references.citation: J Immunol. 2006 Dec 15;177(12):8512-21
references.pmid: 17142749
references.citation: Immunity. 2008 Nov 14;29(5):704-19
references.pmid: 18976935
references.citation: Transpl Int. 2007 Apr;20(4):353-64
references.pmid: 17326776
references.citation: Bioessays. 2007 Apr;29(4):356-70
references.pmid: 17373658
references.citation: Eur J Immunol. 2005 Jun;35(6):1977-86
references.pmid: 15884057
references.citation: Immunity. 2001 Nov;15(5):703-13
references.pmid: 11728333
references.citation: Nat Immunol. 2004 Mar;5(3):247-53
references.pmid: 14985712
references.citation: J Immunol. 2005 Jul 1;175(1):350-7
references.pmid: 15972668
references.citation: Nat Immunol. 2001 Jun;2(6):542-7
references.pmid: 11376342
references.citation: Mol Cell Biol. 2001 Oct;21(20):6906-12
references.pmid: 11564874
references.citation: Immunity. 2008 Jan;28(1):88-99
references.pmid: 18191593
references.citation: Mol Cell Biol. 2004 Jan;24(2):719-29
references.pmid: 14701744
references.citation: Blood. 2008 Sep 1;112(5):1767-75
references.pmid: 18579797
references.citation: Nat Rev Mol Cell Biol. 2005 Feb;6(2):167-80
references.pmid: 15688002
references.citation: J Cell Sci. 2004 Mar 15;117(Pt 8):1301-12
references.pmid: 15020670
references.citation: Biochem Biophys Res Commun. 2008 Aug 8;372(4):941-6
references.pmid: 18541143
references.citation: Eur J Immunol. 2003 Mar;33(3):790-7
references.pmid: 12616499
references.citation: Nat Immunol. 2005 Mar;6(3):261-70
references.pmid: 15696170
references.citation: Blood. 2008 Mar 1;111(5):2714-24
references.pmid: 18094331
references.citation: Blood. 2005 Apr 15;105(8):3026-34
references.pmid: 15618472
references.citation: Eur J Immunol. 2004 Mar;34(3):806-816
references.pmid: 14991610
references.citation: Hum Immunol. 2003 Apr;64(4):389-401
references.pmid: 12651066
references.citation: Nature. 2001 Aug 23;412(6849):826-31
references.pmid: 11518968
references.citation: Proc Natl Acad Sci U S A. 1995 May 23;92(11):5027-31
references.pmid: 7761442
references.citation: Biol Cell. 2007 Feb;99(2):67-86
references.pmid: 17222083
references.citation: J Exp Med. 2002 Jan 21;195(2):189-200
references.pmid: 11805146
references.citation: Nat Immunol. 2001 Sep;2(9):855-62
references.pmid: 11526402
references.citation: J Immunol. 2006 Oct 15;177(8):5024-31
references.pmid: 17015685
references.citation: Trends Cell Biol. 2005 Jul;15(7):356-63
references.pmid: 15921909
references.citation: Blood. 2009 Apr 23;113(17):3990-8
references.pmid: 19088377
references.citation: Immunity. 2008 Aug 15;29(2):193-204
references.pmid: 18701083
references.citation: Blood. 2005 Aug 15;106(4):1286-95
references.pmid: 15845902
references.citation: J Clin Invest. 2007 Aug;117(8):2164-75
references.pmid: 17657315
references.citation: Immunity. 2004 Sep;21(3):429-41
references.pmid: 15357953
references.citation: Nat Immunol. 2001 Jun;2(6):548-55
references.pmid: 11376343
references.citation: Immunity. 2002 Mar;16(3):331-43
references.pmid: 11911819
references.citation: J Exp Med. 2003 Nov 17;198(10):1595-608
references.pmid: 14623913
references.citation: Nat Immunol. 2000 Oct;1(4):348-52
references.pmid: 11017108
references.citation: J Clin Invest. 2006 Mar;116(3):703-14
references.pmid: 16470246
references.citation: Nature. 1995 Mar 30;374(6521):470-3
references.pmid: 7700359
references.citation: Eur J Immunol. 1999 Feb;29(2):477-87
references.pmid: 10064063
references.citation: Nat Immunol. 2006 Nov;7(11):1182-90
references.pmid: 17028588
references.citation: Nature. 1992 Mar 5;356(6364):71-4
references.pmid: 1531699
references.citation: J Neuroimmunol. 2003 Jun;139(1-2):17-26
references.pmid: 12799016
references.citation: Mol Cell Biol. 2008 Jun;28(11):3776-89
references.pmid: 18378701
references.citation: J Cell Biol. 2007 Mar 12;176(6):863-75
references.pmid: 17353362
references.citation: Eur J Immunol. 1999 Nov;29(11):3609-20
references.pmid: 10556816
references.citation: Blood. 2005 Jul 15;106(2):635-40
references.pmid: 15811961
references.citation: J Immunol. 1999 Jul 1;163(1):137-42
references.pmid: 10384109
references.citation: Curr Biol. 1998 May 7;8(10):563-72
references.pmid: 9601640
references.citation: Int Immunol. 2003 Feb;15(2):215-21
references.pmid: 12578851
references.citation: Nature. 1997 Jan 9;385(6612):169-72
references.pmid: 8990121
references.citation: Nature. 1995 Mar 30;374(6521):467-70
references.pmid: 7700358
references.citation: J Biol Chem. 2002 May 3;277(18):15376-84
references.pmid: 11859076
references.citation: Immunity. 2005 Nov;23(5):527-38
references.pmid: 16286020
references.citation: Nat Immunol. 2009 Apr;10(4):361-4
references.pmid: 19295633
references.citation: Immunity. 2008 Dec 19;29(6):899-911
references.pmid: 19062315
references.citation: J Exp Med. 2001 Oct 1;194(7):915-26
references.pmid: 11581314
references.citation: Blood. 2002 Dec 1;100(12):3968-74
references.pmid: 12393632
references.citation: Mol Cell Biol. 1998 Jul;18(7):3936-46
references.pmid: 9632778
references.citation: Cell. 2005 May 6;121(3):425-36
references.pmid: 15882624
references.citation: EMBO J. 2002 Sep 16;21(18):4809-19
references.pmid: 12234921
references.citation: Immunity. 1997 Jul;7(1):163-74
references.pmid: 9252129
references.citation: J Cell Sci. 2003 Aug 1;116(Pt 15):3123-33
references.pmid: 12799414
references.citation: J Exp Med. 2002 May 6;195(9):1103-14
references.pmid: 11994416