title: Pulmonary epithelial lining fluid concentrations after use of systemic amphotericin B lipid formulations.
abstract: Amphotericin B (AMB) concentrations were determined in pulmonary epithelial lining fluid (ELF) of 44 critically ill patients, who were receiving treatment with liposomal AMB (LAMB) (n = 11), AMB colloidal dispersion (ABCD) (n = 28), or AMB lipid complex (ABLC) (n = 5). Mean AMB levels (+/- standard errors of the means) in ELF amounted to 1.60 +/- 0.58, 0.38 +/- 0.07, and 1.29 +/- 0.71 microg/ml in LAMB-, ABCD-, and ABLC-treated patients, respectively (differences are not significant).
authors.affiliation: Inflammation Research Laboratory, Department of Internal Medicine I, Innsbruck Medical University, Anichstrasse 35, A-6020 Innsbruck, Austria.
authors.forename: Stefan
authors.initials: S
authors.lastname: Weiler
authors.forename: Gerda
authors.initials: G
authors.lastname: Falkensammer
authors.forename: Angelika
authors.initials: A
authors.lastname: Hammerer-Lercher
authors.forename: Markus
authors.initials: M
authors.lastname: Anliker
authors.forename: Helene
authors.initials: H
authors.lastname: Vogelsinger
authors.forename: Michael
authors.initials: M
authors.lastname: Joannidis
authors.forename: Stefan
authors.initials: S
authors.lastname: Dunzendorfer
authors.forename: Markus
authors.initials: M
authors.lastname: Stein
authors.forename: Romuald
authors.initials: R
authors.lastname: Bellmann
mesh_terms: D000328:Adult; D000666:Amphotericin B / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000935:Antifungal Agents / Q000493:pharmacokinetics*; D004848:Epithelium / Q000378:metabolism; D005260:Female; D006801:Humans; D008168:Lung / Q000378:metabolism*; D008297:Male; D008875:Middle Aged
chemical_list: D000935:Antifungal Agents; C068538:liposomal amphotericin B; D000666:Amphotericin B
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