title: Review article: management of acute severe and near-fatal asthma.
abstract: Despite a decline in the Australian overall asthma mortality, near-fatal/critical asthma continues to be a significant management issue for emergency physicians and intensivists. Near-fatal asthma is a unique subtype of asthma, with a variety of clinical presentations, requiring rapid and aggressive intervention. The pharmacological and non-pharmacological management of near-fatal asthma remains very complex. The present review discusses recent advances and evidence for current available strategies targeting this time critical emergency.
authors.affiliation: Department of Intensive Care Medicine, The University of Queensland, Queensland, Australia. Anthony_holley@health.qld.gov.au
authors.forename: Anthony D
authors.initials: AD
authors.lastname: Holley
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Boots
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000316:Adrenergic alpha-Agonists / Q000627:therapeutic use; D000318:Adrenergic beta-Agonists / Q000627:therapeutic use*; D000368:Aged; D000420:Albuterol / Q000627:therapeutic use*; D000628:Aminophylline / Q000627:therapeutic use; D001249:Asthma / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D001993:Bronchodilator Agents / Q000627:therapeutic use; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D018680:Cholinergic Antagonists / Q000627:therapeutic use; D004837:Epinephrine / Q000627:therapeutic use; D017408:Guidelines as Topic; D006801:Humans; D009241:Ipratropium / Q000627:therapeutic use; D008278:Magnesium Sulfate / Q000627:therapeutic use; D010100:Oxygen / Q000008:administration & dosage / Q000627:therapeutic use*; D012121:Respiration, Artificial / Q000379:methods; D012131:Respiratory Insufficiency / Q000209:etiology / Q000628:therapy*; D012307:Risk Factors
chemical_list: D000305:Adrenal Cortex Hormones; D000316:Adrenergic alpha-Agonists; D000318:Adrenergic beta-Agonists; D001993:Bronchodilator Agents; D002121:Calcium Channel Blockers; D018680:Cholinergic Antagonists; D000628:Aminophylline; D008278:Magnesium Sulfate; D009241:Ipratropium; D000420:Albuterol; D010100:Oxygen; D004837:Epinephrine