title: VEGF-B: a survival, or an angiogenic factor?
abstract: Despite its early discovery and high sequence homology to the other VEGF family members, the biological function of VEGF-B remained debatable for a long time, and VEGF-B has received little attention from the field thus far. Recently, we and others have found that (1) VEGF-B is a potent survival factor for different types of cells by inhibiting apoptosis via suppressing the expression of BH3-only protein and other apoptotic/cell death-related genes. (2) VEGF-B has a negligible role in inducing blood vessel growth in most organs. Instead, it is critically required for blood vessel survival. VEGF-B targeting inhibited pathological angiogenesis by abolishing blood vessel survival in different animal models. (3) Using different types of neuro-injury and neurodegenerative disease models, VEGF-B treatment protected endangered neurons from apoptosis without inducing undesired blood vessel growth or permeability. Thus, VEGF-B is the first member of the VEGF family that has a potent survival/anti-apoptotic effect, while lacking a general angiogenic activity. Our work thus advocates that the major function of VEGF-B is to act as a "survival", rather than an "angiogenic" factor and implicates a therapeutic potential of VEGF-B in treating different types of vascular and neurodegenerative diseases.
authors.affiliation: National Eye Institute, National Institutes of Health, Bethesda, MD, USA. lixur@nei.nih.gov
authors.forename: Xuri
authors.initials: X
authors.lastname: Li
authors.forename: Chunsik
authors.initials: C
authors.lastname: Lee
authors.forename: Zhongshu
authors.initials: Z
authors.lastname: Tang
authors.forename: Fan
authors.initials: F
authors.lastname: Zhang
authors.forename: Pachiappan
authors.initials: P
authors.lastname: Arjunan
authors.forename: Yang
authors.initials: Y
authors.lastname: Li
authors.forename: Xu
authors.initials: X
authors.lastname: Hou
authors.forename: Anil
authors.initials: A
authors.lastname: Kumar
authors.forename: Lijin
authors.initials: L
authors.lastname: Dong
mesh_terms: D042501:Angiogenic Proteins / Q000502:physiology*; D000818:Animals; D051017:Apoptosis Regulatory Proteins / Q000502:physiology*; D002470:Cell Survival / Q000502:physiology; D006801:Humans; D042561:Vascular Endothelial Growth Factor B / Q000502:physiology*
chemical_list: D042501:Angiogenic Proteins; D051017:Apoptosis Regulatory Proteins; D042561:Vascular Endothelial Growth Factor B
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