title: [Case report of mucormycosis in a patient with secondary methimazole-induced agranulocytosis].
abstract: Agranulocytosis is a rare side effect of antithyroid drugs, it occurs in less than 0.5% of patients, usually during the first few months of treatment. It is considered to be the most serious adverse effect of these medications since it may be complicated by serious, life-threatening infections. Mucormycosis is a severe mycotic infection that usually develops in immunocompromised hosts, such aspatients with diabetes mellitus, hematologic malignancies or immunosuppressive therapy. The association of mucormycosis with methimazole-induced agranulocytosis has not been previously described. The objective of this case presentation is to analyze the case ofa woman with diffuse toxic goiter and methimazole-induced agranulocytosis who developed rhino-palatal mucormycosis.
authors.affiliation: Departamentos de Endocrinologla, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, México D.F., México.
authors.forename: Claudia
authors.initials: C
authors.lastname: Ramírez
authors.forename: Alex Francisco
authors.initials: AF
authors.lastname: Hernández
authors.forename: Verna
authors.initials: V
authors.lastname: Méndez
authors.forename: Silvia
authors.initials: S
authors.lastname: Trejo
authors.forename: Roxana
authors.initials: R
authors.lastname: Contreras
authors.forename: Ana Laura
authors.initials: AL
authors.lastname: Espinosa de los Monteros
authors.forename: Luz Maria
authors.initials: LM
authors.lastname: Gómez
authors.forename: Moisés
authors.initials: M
authors.lastname: Mercado
mesh_terms: D000328:Adult; D000380:Agranulocytosis / Q000139:chemically induced*; D013956:Antithyroid Agents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008713:Methimazole / Q000009:adverse effects*; D009091:Mucormycosis / Q000139:chemically induced*
chemical_list: D013956:Antithyroid Agents; D008713:Methimazole