title: Influence of menopause on diabetes and diabetes risk.
abstract: Many postmenopausal women live with diabetes mellitus; however, little information is available about how the changes that occur around the time of menopause might uniquely affect management of diabetes mellitus in this population. Although the weight gain that commonly occurs during the menopausal transition is largely attributable to aging rather than the transition itself, changes in body composition have been independently associated with menopausal status. These changes in body composition have, in turn, been associated with alterations in insulin sensitivity and glucose metabolism in postmenopausal women. Hormone therapy seems to have neutral or beneficial effects on the adverse changes in body composition associated with menopause. Whether menopausal status independently influences diabetes risk remains controversial. Nevertheless, consistent findings from large clinical trials suggest that postmenopausal hormone therapy decreases the risk of developing diabetes mellitus. Similarly, many studies suggest that postmenopausal hormone therapy has neutral or beneficial effects on glycemic control among women already diagnosed as having diabetes mellitus. Future studies are needed to elucidate the mechanisms that underlie these relationships and to determine how these observations should influence recommendations for the care of postmenopausal women with diabetes mellitus.
authors.affiliation: Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University, Chicago, IL, USA.
authors.forename: Emily D
authors.initials: ED
authors.lastname: Szmuilowicz
authors.forename: Cynthia A
authors.initials: CA
authors.lastname: Stuenkel
authors.forename: Ellen W
authors.initials: EW
authors.lastname: Seely
mesh_terms: D001823:Body Composition; D003920:Diabetes Mellitus / Q000139:chemically induced / Q000453:epidemiology* / Q000209:etiology; D015914:Estrogen Replacement Therapy; D005260:Female; D006801:Humans; D008593:Menopause / Q000502:physiology*; D012307:Risk Factors
references.citation: Fertil Steril. 2001 Nov;76(5):874-8
references.pmid: 11704104
references.citation: N Engl J Med. 2004 May 13;350(20):2068-79
references.pmid: 15141045
references.citation: Circulation. 2007 Mar 20;115(11):1481-501
references.pmid: 17309915
references.citation: Nature. 2006 Dec 14;444(7121):881-7
references.pmid: 17167477
references.citation: J Clin Endocrinol Metab. 2005 May;90(5):2701-7
references.pmid: 15687338
references.citation: Diabetes Obes Metab. 2006 Sep;8(5):538-54
references.pmid: 16918589
references.citation: J Clin Endocrinol Metab. 2007 Apr;92(4):1289-95
references.pmid: 17244779
references.citation: Maturitas. 1998 Jun 17;29(3):247-52
references.pmid: 9699196
references.citation: Diabetes Care. 2006 Feb;29(2):312-6
references.pmid: 16443879
references.citation: Climacteric. 2003 Mar;6(1):67-74
references.pmid: 12776693
references.citation: J Clin Endocrinol Metab. 2003 Jun;88(6):2404-11
references.pmid: 12788835
references.citation: Diabetes Care. 2002 Jan;25(1):55-60
references.pmid: 11772901
references.citation: Ann Intern Med. 1999 Apr 6;130(7):545-53
references.pmid: 10189323
references.citation: J Clin Endocrinol Metab. 2001 Jan;86(1):48-52
references.pmid: 11231977
references.citation: Menopause. 1999 Summer;6(2):174-8
references.pmid: 10374226
references.citation: Metabolism. 1991 Dec;40(12):1323-6
references.pmid: 1961129
references.citation: Diabetologia. 1997 Jul;40(7):843-9
references.pmid: 9243107
references.citation: Am J Med. 2005 Dec 19;118 Suppl 12B:64-73
references.pmid: 16414329
references.citation: Ann Intern Med. 2003 Jan 7;138(1):1-9
references.pmid: 12513038
references.citation: Med Sci Sports Exerc. 2005 Jul;37(7):1195-202
references.pmid: 16015138
references.citation: J Clin Endocrinol Metab. 2001 Mar;86(3):1140-3
references.pmid: 11238498
references.citation: Am J Clin Nutr. 1999 Sep;70(3):405-11
references.pmid: 10479203
references.citation: Maturitas. 1996 Aug;25(1):11-9
references.pmid: 8887304
references.citation: JAMA. 2002 Jul 17;288(3):321-33
references.pmid: 12117397
references.citation: Gend Med. 2006 Jun;3(2):131-58
references.pmid: 16860272
references.citation: Arch Intern Med. 2002 Jan 28;162(2):209-16
references.pmid: 11802755
references.citation: Diabetes Care. 2003 Nov;26(11):2977-82
references.pmid: 14578226
references.citation: Am J Obstet Gynecol. 1996 Dec;175(6):1594-600
references.pmid: 8987946
references.citation: Diabetes. 2001 Aug;50(8):1857-62
references.pmid: 11473049
references.citation: Am J Epidemiol. 1993 Nov 1;138(9):688-96
references.pmid: 8237984
references.citation: Diabetes Care. 2003 Apr;26(4):1016-21
references.pmid: 12663566
references.citation: JAMA. 2004 Apr 14;291(14):1701-12
references.pmid: 15082697
references.citation: Am J Epidemiol. 2006 Dec 15;164(12):1150-9
references.pmid: 17041127
references.citation: Fertil Steril. 2000 Jan;73(1):61-5
references.pmid: 10632413
references.citation: Diabetes Care. 1996 Apr;19(4):333-40
references.pmid: 8729156
references.citation: Arch Intern Med. 2008 Jul 28;168(14):1568-75
references.pmid: 18663170
references.citation: J Clin Endocrinol Metab. 1997 Feb;82(2):638-43
references.pmid: 9024268
references.citation: Diabetologia. 2006 Mar;49(3):459-68
references.pmid: 16440209
references.citation: Diabetes Care. 2002 Oct;25(10):1675-80
references.pmid: 12351460
references.citation: JAMA. 2006 May 3;295(17):2057-71
references.pmid: 16670414
references.citation: Maturitas. 2000 Dec 29;37(2):95-104
references.pmid: 11137328
references.citation: Am J Clin Nutr. 1992 May;55(5):950-4
references.pmid: 1570802
references.citation: Diabetes Care. 1999 Sep;22(9):1401-7
references.pmid: 10480500
references.citation: J Clin Endocrinol Metab. 2007 Mar;92(3):895-901
references.pmid: 17192296
references.citation: Menopause. 2009 Jul-Aug;16(4):817-21
references.pmid: 19387417
references.citation: JAMA. 1996 Jan 3;275(1):46-9
references.pmid: 8531286
references.citation: Metabolism. 2005 Dec;54(12):1626-31
references.pmid: 16311096
references.citation: Am J Hypertens. 2009 Apr;22(4):364-70
references.pmid: 19214164
references.citation: JAMA. 1998 Dec 2;280(21):1843-8
references.pmid: 9846779
references.citation: Maturitas. 1997 Sep;28(1):35-45
references.pmid: 9391993
references.citation: Am J Epidemiol. 2001 May 1;153(9):865-74
references.pmid: 11323317
references.citation: Arch Mal Coeur Vaiss. 1991 Aug;84(8):1111-5
references.pmid: 1953259
references.citation: Maturitas. 2000 Mar 31;34(3):239-47
references.pmid: 10717490
references.citation: Arch Intern Med. 2001 Jul 23;161(14):1772-6
references.pmid: 11485511
references.citation: Metabolism. 1995 Mar;44(3):369-73
references.pmid: 7885283
references.citation: Diabetes Care. 2001 Jul;24(7):1144-50
references.pmid: 11423493
references.citation: J Clin Endocrinol Metab. 2008 Apr;93(4):1276-84
references.pmid: 18182456
references.citation: Am J Public Health. 1997 Mar;87(3):443-5
references.pmid: 9096551
references.citation: Am J Clin Nutr. 1994 Dec;60(6):843-8
references.pmid: 7985622
references.citation: Diabetes Care. 2005 Jul;28(7):1730-8
references.pmid: 15983327
references.citation: Diabetes Care. 1998 Oct;21(10):1589-95
references.pmid: 9773716
references.citation: Lancet. 2008 Mar 1;371(9614):760-70
references.pmid: 18313505
references.citation: Ann Epidemiol. 1992 Sep;2(5):665-73
references.pmid: 1342318
references.citation: J Clin Endocrinol Metab. 1997 May;82(5):1549-56
references.pmid: 9141548
references.citation: Circulation. 2001 Jan 2;103(1):32-7
references.pmid: 11136682
references.citation: Diabetes Self Manag. 2007 Jan-Feb;24(1):84-7
references.pmid: 17283513
references.citation: Diabetes Care. 2004 Mar;27(3):645-9
references.pmid: 14988279
references.citation: Diabetologia. 2004 Jul;47(7):1175-1187
references.pmid: 15252707