Fly antiviral RNA silencing and miRNA biogenesis claim ARS2.
In plants and invertebrates, small silencing RNAs function in antiviral defense and developmental patterning through pathways that were so far considered genetically distinct. In a recent issue of Cell, Sabin and colleagues report the identification of Drosophila Ars2, a protein required for both these small RNA-mediated functions.
Voinnet
Olivier
O
Institut de Biologie Moléculaire des Plantes, Université de Strasbourg, CNRS UPR 2357, 67084 Strasbourg Cedex, France. olivier.voinnet@ibmp-ulp.u-strasbg.fr
D000818:Animals; D004330:Drosophila / Q000235:genetics / Q000276:immunology* / Q000502:physiology* / Q000821:virology; D029721:Drosophila Proteins / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental; D020868:Gene Silencing; D035683:MicroRNAs / Q000378:metabolism*
C542810:Ars2 protein, Drosophila; D029721:Drosophila Proteins; D035683:MicroRNAs