[Pharmacokinetic study of amrubicin in a case of small lung cancer on hemodialysis].
Amrubicin is a new anticancer drug that has been shown to exert efficacy against small cell lung cancer. The pharmacokinetic parameters of amrubicin have not yet been investigated in hemodialysis patients, although it had been expected that amrubicin might not be cleared by hemodialysis because of its high lipid solubility, high protein binding rate and low urinary excretion rate. We encountered a case of small cell lung cancer on hemodialysis who was treated with amrubicin. We assayed the plasma concentrations of amrubicin and amrubicinol (its active metabolite) and analyzed the pharmacokinetic parameters of the drug in this hemodialysis patient. The results revealed that the pharmacokinetic parameters of the drug in this patient undergoing hemodialysis were similar to those in patients not on hemodialysis. Our results suggest that amrubicin and amrubicinol are cleared by hemodialysis, and that dose adjustment of amrubicin might not be required in hemodialysis patients.
Ohsawa
Machiko
M
Dept. of Pharmacy, Itami City Hospital.
Demizu
Mutsuko
M
Chihara
Satomi
S
Ueda
Hiroshi
H
Igarashi
Tsutomu
T
Tomiyama
Naoki
N
Nakashima
Yuko
Y
Hosoi
Keita
K
Min
Kyonyobi
K
D018943:Anthracyclines / Q000493:pharmacokinetics*; D000970:Antineoplastic Agents / Q000493:pharmacokinetics*; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D055752:Small Cell Lung Carcinoma / Q000188:drug therapy / Q000378:metabolism*
D018943:Anthracyclines; D000970:Antineoplastic Agents; C116173:amrubicinol; C055866:amrubicin