Forms of iron binding in the cells and the chemical features of chelation therapy.
Iron is essential for human life, however it can be toxic through Fe ability to generate oxygen-derived radicals. This work reviews the main features of Fe binding in the cell and its association to these processes. The chemical nature of the Fe extracted by chelation therapy in pathophysiological situations is also analyzed.
Puntarulo
S
S
Physical Chemistry-PRALIB, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina. susanap@ffyb.uba.ar
Galleano
M
M
D000818:Animals; D015913:Chelation Therapy; D006801:Humans; D007501:Iron / Q000378:metabolism*; D007502:Iron Chelating Agents / Q000737:chemistry* / Q000627:therapeutic use*
D007502:Iron Chelating Agents; D007501:Iron