title: Conservative surgical management of stage IA endometrial carcinoma for fertility preservation.
abstract: OBJECTIVE
  To describe an innovative method to preserve fertility in young women with stage IA endometrial cancer with use of hysteroscopic resection followed by administration of 160 mg of megestrol acetate.
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  Division of Gynecologic Oncology, Catholic University of the Sacred Heart, and the Endoscopic Gynecologic Unit, Nuova Villa Claudia, Rome, Italy.
  
  
  METHODS
  Six young patients with stage IA endometrial cancer.
  
  
  METHODS
  Conservative resectoscopic treatment using a three-step technique in which each step is characterized by a pathologic analysis: the removal of the tumor (step 1), the removal of the endometrium adjacent to the tumor (step 2), and the removal of the myometrium underlying the tumor (step 3).
  
  
  METHODS
  Therapy of stage IA endometrial cancer and pregnancy.
  
  
  RESULTS
  The conservative surgery was effective because results of transvaginal ultrasound examination and diagnostic hysteroscopy with target biopsies at 3, 6, 9, and 12 months after surgery were negative for atypia or malignancy. Moreover, four out of six patients (66%) achieved childbearing.
  
  
  CONCLUSIONS
  This method, under a close postsurgical follow-up, might represent a novel therapeutic option for those women with stage IA endometrial cancer who wish to preserve fertility.
authors.affiliation: Endoscopic Gynecologic Unit, Nuova Villa Claudia, Via Flaminia Nuova, 280-00191 Rome, Italy. i.mazzon@arborvitae.it
authors.forename: Ivan
authors.initials: I
authors.lastname: Mazzon
authors.forename: Giacomo
authors.initials: G
authors.lastname: Corrado
authors.forename: Valeria
authors.initials: V
authors.lastname: Masciullo
authors.forename: Daniela
authors.initials: D
authors.lastname: Morricone
authors.forename: Gabriella
authors.initials: G
authors.lastname: Ferrandina
authors.forename: Giovanni
authors.initials: G
authors.lastname: Scambia
mesh_terms: D000328:Adult; D019468:Disease Management; D016889:Endometrial Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D005260:Female; D005298:Fertility / Q000187:drug effects / Q000502:physiology; D020249:Hormone Replacement Therapy / Q000379:methods; D006801:Humans; D009367:Neoplasm Staging / Q000379:methods; D011446:Prospective Studies; D014594:Uterine Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*