title: sTNFR-1 is an early inflammatory marker in community versus institutionalized elderly women.
abstract: OBJECTIVE
  To evaluate plasma sTNFR-1 and IL-6 levels and correlate with hand grip in the institutionalized and community living Brazilian elderly.
  
  
  METHODS
  A convenience sample of 110 elderly women (71.17 + or - 7.44 years) was selected. Plasma sTNFR-1 and IL-6 levels were measured by ELISA. For the measurement of hand grip, a JAMAR dynamometer was used.
  
  
  RESULTS
  Plasma concentrations of inflammatory markers were significantly higher in institutionalized elderly (sTNFR-1: 479 + or - 22 pg/mL; IL-6: 6.3 + or - 0.8 pg/mL) than in community-dwelling elderly (sTNFR-1: 329 + or - 24 pg/mL; IL-6: 2.5 + or - 0.4 pg/mL; P < 0.0001). Institutionalized elderly had reduced hand grip (15 + or - 0.8 Kgf) in comparison to community dwelling elderly (23 + or - 0.6 Kgf; P < 0.05). When individuals were subdivided in age groups, sTNFR-1 was higher in community dwelling versus institutionalized elderly in the 60-70 age range.
  
  
  CONCLUSIONS
  Our results demonstrate that being institutionalized has an impact on levels of inflammatory markers.
authors.affiliation: Laboratório da Dor e Inflamação em Reabilitação Sala 2102-A., Departamento de Fisioterapia da Escola de Educação Física, Fisioterapia e Terapia, Ocupacional, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Av. Antonio Carlos 6627, Pampulha, 31270-901 Belo Horizonte, MG, Brazil. fematoscoelho@gmail.com
authors.forename: Fernanda Matos
authors.initials: FM
authors.lastname: Coelho
authors.forename: F M S
authors.initials: FM
authors.lastname: Narciso
authors.forename: D M G
authors.initials: DM
authors.lastname: Oliveira
authors.forename: D S
authors.initials: DS
authors.lastname: Pereira
authors.forename: A L
authors.initials: AL
authors.lastname: Teixeira
authors.forename: M M
authors.initials: MM
authors.lastname: Teixeira
authors.forename: D G
authors.initials: DG
authors.lastname: Souza
authors.forename: L S M
authors.initials: LS
authors.lastname: Pereira
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D001938:Brazil; D003430:Cross-Sectional Studies; D005260:Female; D018737:Hand Strength / Q000502:physiology; D006801:Humans; D057187:Independent Living; D007249:Inflammation / Q000097:blood*; D007326:Institutionalization; D015850:Interleukin-6 / Q000097:blood; D008875:Middle Aged; D053581:Muscle Strength Dynamometer; D047888:Receptors, Tumor Necrosis Factor, Type I / Q000097:blood*; D012111:Residence Characteristics; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D015415:Biomarkers; D015850:Interleukin-6; D047888:Receptors, Tumor Necrosis Factor, Type I; D014409:Tumor Necrosis Factor-alpha
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