title: Dysoxylum binectariferum Hook.f (Meliaceae), a rich source of rohitukine.
abstract: Rohitukine, a chromane alkaloid, is a precursor of flavopiridol, a promising anti-cancer compound. Currently in Phase III clinical trials, flavopiridol is a potent inhibitor of several cyclin-dependent kinases (CDKs). Rohitukine was first reported from Amoora rohituka (0.083% dry weight) followed by that in Dysoxylum binectariferum (0.9% dry weight), both belonging to the family Meliaceae. Here, we report incredibly high yields of rohitukine (7% dry weight) in trees of D. binectariferum from the Western Ghats, India. Crude extracts of the tree were found to be highly effective against ovarian and breast cancer lines tested.
authors.affiliation: Department of Crop Physiology, University of Agricultural Sciences, GKVK Campus, Bangalore 560065, India.
authors.forename: Patel
authors.initials: P
authors.lastname: Mohanakumara
authors.forename: Nambiar
authors.initials: N
authors.lastname: Sreejayan
authors.forename: Vaidayanathan
authors.initials: V
authors.lastname: Priti
authors.forename: Bheemanahally Thimmappa
authors.initials: BT
authors.lastname: Ramesha
authors.forename: Gudasalamani
authors.initials: G
authors.lastname: Ravikanth
authors.forename: Kotiganahalli Narayanagowda
authors.initials: KN
authors.lastname: Ganeshaiah
authors.forename: Ramesh
authors.initials: R
authors.lastname: Vasudeva
authors.forename: John
authors.initials: J
authors.lastname: Mohan
authors.forename: Thankayyan Retnabai
authors.initials: TR
authors.lastname: Santhoshkumar
authors.forename: Prabhu Dutt
authors.initials: PD
authors.lastname: Mishra
authors.forename: Viswakarma
authors.initials: V
authors.lastname: Ram
authors.forename: Ramanan Uma
authors.initials: RU
authors.lastname: Shaanker
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy; D045744:Cell Line, Tumor; D005260:Female; D005419:Flavonoids / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D007194:India; D036701:Limonins / Q000302:isolation & purification* / Q000627:therapeutic use; D029582:Meliaceae / Q000737:chemistry*; D009369:Neoplasms / Q000188:drug therapy*; D010051:Ovarian Neoplasms / Q000188:drug therapy; D008517:Phytotherapy; D010880:Piperidines / Q000494:pharmacology* / Q000627:therapeutic use; D024301:Plant Bark; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification* / Q000627:therapeutic use; D018547:Plant Stems; D047428:Protein Kinase Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D014197:Trees / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids; D036701:Limonins; D010880:Piperidines; D010936:Plant Extracts; D047428:Protein Kinase Inhibitors; C077990:alvocidib; C105839:rohitukin