title: Allopatric femtosecond laser gas-bubble formation in a closed system.
abstract: OBJECTIVE
  To test a possible mechanism for allopatric gas-bubble formation in femtosecond laser-assisted surgery using an experimental closed system.
  
  
  METHODS
  Bascom Palmer Eye Institute, University of Miami, Miami, Florida, USA.
  
  
  METHODS
  Plastic bottles were filled with balanced salt solution (BSS). Femtosecond laser (IntraLase) flap-mode cuts were made on the walls of the BSS bottles. After femtosecond laser application, the BSS bottles were viewed under the excimer laser microscope and the results photographed. Next, the BSS bottles and laser cuts were imaged with optical coherence tomography.
  
  
  RESULTS
  In-bottle gas bubbles were consistently produced in the closed system. No cut lines crossed the inner wall of the BSS bottles.
  
  
  CONCLUSIONS
  Results show that in situ gas-bubble formation as a mechanism for gas-bubble formation is a possible alternative to gas traveling through the anterior segment and into the intraflap laser space.
authors.affiliation: Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida 33136, USA.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Ide
authors.forename: Sonia H
authors.initials: SH
authors.lastname: Yoo
authors.forename: Richard K
authors.initials: RK
authors.lastname: Lee
authors.forename: Terrence P
authors.initials: TP
authors.lastname: O'Brien
mesh_terms: D005740:Gases; D053685:Laser Therapy; D054018:Lasers, Excimer; D045423:Microbubbles; D008954:Models, Biological; D010969:Plastics; D013524:Surgical Flaps; D041623:Tomography, Optical Coherence
chemical_list: D005740:Gases; D010969:Plastics