The interleukin-18 inhibitory activities of echinocystic acid and its saponins from Impatiens pritzellii var. hupehensis.
Echinocystic acid (1), an echinocystic acid saponin, 2, and four of its ester saponins, 3-6, obtained from the active fraction of Impatiens pritzellii var. hupehensis, an traditional Chinese medicine for rheumatoid arthritis, were investigated for their effects on lipopolysaccharide (LPS)-induced interleukin (IL)-18 in human peripheral blood mononuclear cells. Three of them, 1, 2 and 6, showed obvious activity to inhibit the production of IL-18, especially the ester saponins with a sugar chain at C-28, 6. Structure-activity relationships are discussed in brief.
Zhou
Xue-Feng
XF
Key Laboratory of Marine Bio-resources Sustainable Utilization, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China.
Tang
Lan
L
Zhang
Peng
P
Zhaod
Xiao-Ya
XY
Pi
Hui-Fang
HF
Zhang
Yong-Hui
YH
Ruan
Han-Li
HL
Liu
Yonghong
Y
Wu
Ji-Zhou
JZ
D006801:Humans; D029069:Impatiens / Q000737:chemistry*; D020382:Interleukin-18 / Q000037:antagonists & inhibitors*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008516:Medicine, Chinese Traditional; D009000:Monocytes / Q000187:drug effects / Q000502:physiology*; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D012503:Saponins / Q000302:isolation & purification / Q000494:pharmacology*
D020382:Interleukin-18; D008070:Lipopolysaccharides; D012503:Saponins; D009828:Oleanolic Acid; C022999:echinocystic acid