Efficient microwave assisted syntheses of 2,5-diketopiperazines in aqueous media.
Aqueous in situ one-pot N-Boc-deprotection-cyclization of N alpha-Boc-dipeptidyl-tert-butyl and methyl esters under microwave irradiation afforded 2,5-diketopiperazines (DKPs) in excellent yields. This protocol is rapid, safe, environmentally friendly, and highly efficient, and showed that the tert-butoxy moiety is also an excellent leaving group for these cyclizations.
Pérez-Picaso
Lemuel
L
Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa, 62209 Cuernavaca, Morelos, México.
Escalante
Jaime
J
Olivo
Horacio F
HF
Rios
María Yolanda
MY
D054659:Diketopiperazines / Q000138:chemical synthesis* / Q000737:chemistry*; D004952:Esters / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008872:Microwaves; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000737:chemistry
D054659:Diketopiperazines; D004952:Esters; D010456:Peptides, Cyclic
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