title: Liquid chromatography-mass spectrometry in metabolite profiling.
abstract: Recent advances in the use of liquid chromatography-mass spectrometry for the study of metabolomics are reviewed. Sample preparations of biofluids and practical aspects of ultra-high pressure liquid chromatography are discussed. Applicability of different kinds of mass spectrometers for metabolite profiling is described. New tools-ion mobility spectroscopy and automated chip-based nanoelectrospray system with potentials to be applied in the metabolomics analysis are described.
authors.affiliation: Molecular Medicine Research Center, Chang Gung University, Kwei-san, Tao-yuan, Taiwan.
authors.forename: Chiun-Gung
authors.initials: CG
authors.lastname: Juo
authors.forename: Daniel Tsun-Yee
authors.initials: DT
authors.lastname: Chiu
authors.forename: Ming-Shi
authors.initials: MS
authors.lastname: Shiao
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid; D002853:Chromatography, Liquid / Q000379:methods*; D006801:Humans; D013058:Mass Spectrometry / Q000379:methods*; D055432:Metabolomics / Q000379:methods*