title: MWCNTs as reinforcing agent to the hap-gel nanocomposite for artificial bone grafting.
abstract: The essence of this investigation is to explore MWCNTs as reinforcing agents to strengthen Hap-Gel nanocomposites for artificial bone grafting applications without significantly compromising their biocompatibility. Hap-Gelatin composites, reinforced with various proportions of MWCNTs, were synthesized to optimize the MWCNT content in the composites which yield commendable improvement in the strength. The morphological studies reveal that the MWCNTs act as templates for nucleation of Hap crystals. The biocompatibility of MWCNT reinforced Hap-Gelatin composites were evaluated in animal model through the histopathological investigation of tissues from skin, kidney, and liver. On histopathological examination, no noticeable alteration due to toxicity was found for lower concentration of MWCNTs. Mild reversible changes in the liver and tubular damage in kidney have been observed for higher concentration (4 wt % of MWCNTs). It can be inferred from the findings that MWCNTs, in proportions less than 4%, can successfully be used to reinforce the Hap-Gel nanocomposite to improve its mechanical properties. However, how safe would these CNT reinforced bone implants would be when used for prolonged period in actual physiological conditions needs to be investigated further.
authors.affiliation: Department of Physics, Banaras Hindu University, Varanasi 221005, India.
authors.forename: Santosh K
authors.initials: SK
authors.lastname: Yadav
authors.forename: Tanmay
authors.initials: T
authors.lastname: Bera
authors.forename: Preeti S
authors.initials: PS
authors.lastname: Saxena
authors.forename: Ashok K
authors.initials: AK
authors.lastname: Maurya
authors.forename: Rajendra S
authors.initials: RS
authors.lastname: Garbyal
authors.forename: Robert
authors.initials: R
authors.lastname: Vajtai
authors.forename: P
authors.initials: P
authors.lastname: Ramachandrarao
authors.forename: Anchal
authors.initials: A
authors.lastname: Srivastava
mesh_terms: D000818:Animals; D018786:Bone Substitutes / Q000378:metabolism*; D016025:Bone Transplantation / Q000379:methods*; D017886:Durapatite / Q000494:pharmacology*; D004548:Elasticity / Q000187:drug effects; D005782:Gels; D008297:Male; D008422:Materials Testing; D055595:Mechanical Phenomena / Q000187:drug effects; D051379:Mice; D053761:Nanocomposites / Q000737:chemistry* / Q000648:ultrastructure; D037742:Nanotubes, Carbon / Q000737:chemistry* / Q000648:ultrastructure; D009928:Organ Specificity / Q000187:drug effects; D010316:Particle Size; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
chemical_list: D018786:Bone Substitutes; D005782:Gels; D037742:Nanotubes, Carbon; D017886:Durapatite