title: Hydroperoxy-cycloartane triterpenoids from the leaves of Markhamia lutea, a plant ingested by wild chimpanzees.
abstract: In the framework of the phytochemical investigation of plant species eaten by wild chimpanzees in their natural environment in Uganda, leaf samples of Markhamia lutea were selected and collected. The crude ethyl acetate extract of M. lutea leaves exhibited significant in vitro anti-parasitic activity and low cytotoxicity against MRC5 and KB cells. Fractionation of this extract led to six cycloartane triterpenoids, musambins A-C and their 3-O-xyloside derivatives musambiosides A-C. The structures were elucidated on the basis of spectral studies including mass spectroscopy and extensive 2D NMR. Most of the compounds exhibited mild anti-leishmanial and anti-trypanosomal activities.
authors.affiliation: Molécules de Communication et Adaptation des Micro-organismes, Unité Associée au CNRS, Muséum National d'Histoire Naturelle, 57 Rue Cuvier, 75005 Paris, France.
authors.forename: Damien
authors.initials: D
authors.lastname: Lacroix
authors.forename: Soizic
authors.initials: S
authors.lastname: Prado
authors.forename: Alexandre
authors.initials: A
authors.lastname: Deville
authors.forename: Sabrina
authors.initials: S
authors.lastname: Krief
authors.forename: Vincent
authors.initials: V
authors.lastname: Dumontet
authors.forename: John
authors.initials: J
authors.lastname: Kasenene
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Mouray
authors.forename: Christian
authors.initials: C
authors.lastname: Bories
authors.forename: Bernard
authors.initials: B
authors.lastname: Bodo
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000494:pharmacology; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D007891:Leishmania / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D019684:Magnoliopsida / Q000737:chemistry*; D015394:Molecular Structure; D002679:Pan troglodytes; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects; D014315:Triterpenes / Q000737:chemistry / Q000494:pharmacology*; D014344:Trypanocidal Agents / Q000737:chemistry / Q000494:pharmacology; D014349:Trypanosoma cruzi / Q000187:drug effects
chemical_list: D000962:Antimalarials; D000981:Antiprotozoal Agents; D010936:Plant Extracts; D014315:Triterpenes; D014344:Trypanocidal Agents; C085352:cycloartane