Synthesis of functionalized Morita-Baylis-Hillman adducts by a conjugate addition-elimination sequence.
We have developed a new conjugate addition-elimination sequence for the diastereoselective synthesis of protected allylic syn 1,3-diols which are Morita-Baylis-Hillman adducts. The synthesis of the substrates involves a challenging cross-metathesis reaction that leads to hindered trisubstituted olefins.
Aouzal
Rémi
R
Laboratoire de Synthèse Organique, CNRS UMR 7652, Ecole Polytechnique, DCSO, F-91128 Palaiseau, France.
Prunet
Joëlle
J