title: Macular morphology and visual acuity after macular hole surgery with or without internal limiting membrane peeling.
abstract: OBJECTIVE
  To examine postoperative macular morphology and visual outcome after 12 months in relation to internal limiting membrane (ILM) peeling versus no peeling, indocyanine green (ICG) staining and re-operation in eyes that achieved macular hole closure after surgery.
  
  
  METHODS
  Seventy-four eyes with closed stage 2 or 3 macular holes were recruited from a randomised clinical trial comparing: (1) vitrectomy without ILM peeling; (2) vitrectomy with 0.05% isotonic ICG-assisted ILM peeling; and (3) vitrectomy with 0.15% trypan blue-assisted ILM peeling. Contrast-enhanced Stratus optical coherence tomography was used to assess central foveal thickness, central photoreceptor layer thickness (CPRT), central photoreceptor layer discontinuity (PRD) and relative reflectivity of the outer nuclear layer. Outcomes were correlated with best corrected visual acuity (BCVA) 12 months after surgery.
  
  
  RESULTS
  BCVA was correlated with CPRT and PRD. Regression analysis and receiver operating characteristics curve analysis showed that CPRT >33 microm (OR 12.5) and PRD <177 microm (OR 9.86) were highly predictive for regaining reading vision (> or =69 Early Treatment of Diabetic Retinopathy Study letters) 12 months after surgery. No significant difference was found in postoperative macular morphology between subgroups.
  
  
  CONCLUSIONS
  Poor vision after 12 months despite macular hole closure was associated with attenuation and disruption of the foveolar photoreceptor matrix. The extent of attenuation and disruption was independent of peeling and staining.
  
  
  BACKGROUND
  NCT00302328.
authors.affiliation: Department of Ophthalmology, Glostrup Hospital, Nordre Ringvej 57, DK-2600 Glostrup, Denmark. ulrikchristensen@dadlnet.dk
authors.forename: U C
authors.initials: UC
authors.lastname: Christensen
authors.forename: K
authors.initials: K
authors.lastname: Krøyer
authors.forename: B
authors.initials: B
authors.lastname: Sander
authors.forename: T M
authors.initials: TM
authors.lastname: Jorgensen
authors.forename: M
authors.initials: M
authors.lastname: Larsen
authors.forename: M
authors.initials: M
authors.lastname: la Cour
mesh_terms: D000368:Aged; D019773:Epiretinal Membrane / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007208:Indocyanine Green; D008266:Macula Lutea / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D020419:Photoreceptor Cells, Vertebrate / Q000473:pathology; D011379:Prognosis; D012167:Retinal Perforations / Q000473:pathology / Q000601:surgery*; D041623:Tomography, Optical Coherence; D016896:Treatment Outcome; D014792:Visual Acuity; D014821:Vitrectomy / Q000379:methods*
chemical_list: D007208:Indocyanine Green