ISCR2, another vehicle for bla(VEB) gene acquisition.
The expanded-spectrum beta-lactamase (ESBL) gene bla(VEB-1), identified worldwide in Enterobacteriaceae and Pseudomonas aeruginosa, is associated with either class 1 integrons or repeated elements. We report here the first association of bla(VEB-1a) with the insertion sequence ISCR2 in six Acinetobacter species isolates recovered from Argentina. That genetic structure was likely at the origin of the mobilization of this ESBL gene.
Poirel
Laurent
L
Service de Bactériologie-Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris-Sud et Université Paris-Sud, Le Kremlin-Bicêtre, France.
Mugnier
Pauline D
PD
Toleman
Mark A
MA
Walsh
Timothy R
TR
Rapoport
Melina J
MJ
Petroni
Alejandro
A
Nordmann
Patrice
P
D000150:Acinetobacter / Q000201:enzymology / Q000235:genetics*; D000595:Amino Acid Sequence; D001483:Base Sequence; D004251:DNA Transposable Elements; D029968:Escherichia coli Proteins; D008969:Molecular Sequence Data; D001618:beta-Lactamases / Q000737:chemistry / Q000235:genetics*
D004251:DNA Transposable Elements; D029968:Escherichia coli Proteins; C119424:beta-lactamase VEB-1, E coli; D001618:beta-Lactamases
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