title: GC-MS Analysis of beta-Carotene Ethenolysis Products and their Synthesis as Potentially Active Vitamin A Analogues.
abstract: beta-Carotene ethenolysis under promotion of well-defined ruthenium catalysts were examined as a novel method of synthesis of vitamin A derivatives. Efficient reaction was promoted by the second-generation Hoveyda catalyst. The products of ethenolysis in positions C15-C15', C11-C12, and C9-C10 were detected, but cleavage of the C11-C12 double bond predominated. Even better regioselectivity at this position was observed for cross-metathesis between beta-carotene and functionalized alkenes.
authors.affiliation: Institute of Chemistry, University of Bialystok, Al. Pilsudskiego 11/4, 15-443, Bialystok, Poland.
authors.forename: I
authors.initials: I
authors.lastname: Jermacz
authors.forename: J
authors.initials: J
authors.lastname: Maj
authors.forename: J W
authors.initials: JW
authors.lastname: Morzycki
authors.forename: A
authors.initials: A
authors.lastname: Wojtkielewicz
references.citation: Org Lett. 2003 May 29;5(11):2007-9
references.pmid: 12762708
references.citation: Org Lett. 2007 Jan 4;9(1):5-8
references.pmid: 17192071
references.citation: Angew Chem Int Ed Engl. 2003 Apr 29;42(17):1900-23
references.pmid: 12730969
references.citation: Org Lett. 2003 Sep 18;5(19):3439-42
references.pmid: 12967294
references.citation: Free Radic Biol Med. 2003 Dec 1;35(11):1480-90
references.pmid: 14642396
references.citation: Org Lett. 2003 May 29;5(11):1855-8
references.pmid: 12762670
references.citation: Lancet. 1995 Jan 7;345(8941):31-5
references.pmid: 7799706