Cell Adhesion and Transcriptional Activity - Defining the Role of the Novel Protooncogene LPP.
Integrating signals from the extracellular matrix through the cell surface into the nucleus is an essential feature of metazoan life. To date, many signal transducers known as shuttle proteins have been identified to act as both a cytoskeletal and a signaling protein. Among them, the most prominent representatives are zyxin and lipoma preferred (translocation) partner (LPP). These proteins belong to the LIM domain protein family and are associated with cell migration, proliferation, and transcription. LPP was first identified in benign human lipomas and was subsequently found to be overexpressed in human malignancies such as lung carcinoma, soft tissue sarcoma, and leukemia. This review portrays LPP in the context of human neoplasia based on a study of the literature to define its important role as a novel protooncogene in carcinogenesis.
Grunewald
Thomas Gp
TG
Department of Pediatrics, Klinikum rechts der Isar, Technische Universität München, Pediatric Oncology Center, Kölner Platz 1, D-80804 Munich, Germany.
Pasedag
Saskia M
SM
Butt
Elke
E
Neoplasia. 2009 Feb;11(2):207-19
19177205
Curr Biol. 2001 Nov 13;11(22):1739-48
11719215
J Biol Chem. 2000 Jul 21;275(29):22503-11
10801818
Cancer Genet Cytogenet. 2005 Nov;163(1):68-70
16271958
J Med Genet. 2009 Jan;46(1):60-3
18805825
Eur J Cell Biol. 2008 Sep;87(8-9):517-25
18342394
Cytogenet Genome Res. 2006;112(1-2):60-6
16276091
FEBS Lett. 2005 Sep 12;579(22):5061-8
16137684
Genomics. 1998 Apr 15;49(2):314-6
9598321
Int J Oncol. 2008 Feb;32(2):289-305
18202751
Genes Dev. 2006 Jun 15;20(12):1545-56
16778073
Circ Res. 2006 Feb 17;98(3):378-85
16397143
Mol Cancer. 2008 Apr 17;7:31
18419822
Cancer Lett. 2008 Aug 18;267(1):55-66
18439753
Int Rev Cytol. 2005;246:31-58
16164966
J Biol Chem. 2004 Apr 2;279(14):14398-408
14736876
J Cell Biol. 1998 Mar 23;140(6):1383-93
9508771
Gastroenterology. 2005 Jan;128(1):51-62
15633123
Cancer Genet Cytogenet. 2007 Oct 1;178(1):36-41
17889706
EMBO J. 1992 Dec;11(12):4573-82
1330539
Genes Dev. 2007 May 1;21(9):1005-9
17473167
Br J Cancer. 2007 Jan 29;96(2):296-305
17211471
Cell. 2008 Nov 28;135(5):865-78
19041750
Mol Cell Biol. 2000 Nov;20(21):8244-53
11027293
Cancer Genet Cytogenet. 2002 Oct 15;138(2):160-4
12505264
Mol Cell Proteomics. 2008 Sep;7(9):1763-77
18515860
Am J Physiol Cell Physiol. 2003 Sep;285(3):C674-85
12760907
Biochim Biophys Acta. 2006 Aug;1766(1):79-87
16546322
Genomics. 1995 Aug 10;28(3):367-76
7490069
BMC Cell Biol. 2005 Jan 13;6(1):1
15649318
J Biol Chem. 2006 Jun 9;281(23):16178-88
16613855
Oncogene. 2007 Apr 5;26(16):2272-82
17043654
Biochem Biophys Res Commun. 2009 Feb 6;379(2):368-73
19111675
Stem Cell Rev. 2007 Jan;3(1):7-17
17873377
Cancer Genet Cytogenet. 2006 Sep;169(2):102-13
16938567
Carcinogenesis. 2001 Oct;22(10):1583-91
11576996
Mol Cell Biol. 2006 Jun;26(12):4529-38
16738319
Lung Cancer. 2007 Jan;55(1):43-51
17109992
Gene. 2001 Oct 17;277(1-2):63-81
11602345
Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):6062-7
15075390
Cell. 1998 Dec 11;95(6):741-8
9865692
Circ Res. 2007 Mar 30;100(6):817-25
17322171
Exp Cell Res. 2005 Apr 1;304(2):443-56
15748890
Mech Dev. 2000 Mar 1;91(1-2):5-17
10704826
Virchows Arch. 2005 Nov;447(5):855-8
16133369
Cytogenet Cell Genet. 2001;95(3-4):153-6
12063392
Oncogene. 2009 Jan 29;28(4):587-98
18978809
PLoS Med. 2006 Dec;3(12):e516
17194196
Biochem Biophys Res Commun. 2006 Feb 10;340(2):476-81
16375854
Biochem Biophys Res Commun. 2004 Nov 5;324(1):308-16
15465019
Biochem Biophys Res Commun. 2008 Jun 20;371(1):144-8
18413140
Dev Biol. 2008 Aug 1;320(1):267-77
18582857
Cell Mol Life Sci. 2008 Sep;65(17):2688-701
18488141
Mol Cancer Res. 2005 Feb;3(2):63-70
15755872
J Muscle Res Cell Motil. 2009;30(1-2):41-55
19205907
Oncogene. 1998 Jul 30;17(4):413-8
9696033
J Neuropathol Exp Neurol. 2006 Aug;65(8):776-82
16896311
Oncogene. 1991 Sep;6(9):1583-92
1923525
Cancer Genet Cytogenet. 1998 Oct 1;106(1):18-23
9772904
J Cell Biol. 2000 Aug 7;150(3):643-56
10931874
Biochim Biophys Acta. 2003 Feb 17;1593(2-3):115-20
12581855
Trends Genet. 1998 Apr;14(4):156-62
9594664
Circ Res. 2006 Feb 17;98(3):306-8
16484626
Cell. 2003 Apr 4;113(1):37-47
12679033
Histochem Cell Biol. 2006 May;125(5):457-74
16267652
Leukemia. 2008 Oct;22(10):1917-24
18615101
Biochim Biophys Acta. 2001 Apr 23;1538(2-3):260-72
11336797
Adv Exp Med Biol. 2000;480:107-16
10959416
Oncogene. 1995 Apr 6;10(7):1461-3
7731700
Development. 2009 Feb;136(3):383-92
19091770
Cancer Genet Cytogenet. 2001 Sep;129(2):161-4
11566348
Br J Cancer. 2004 Jan 12;90(1):194-9
14710229
Am J Surg Pathol. 2008 Jun;32(6):951-4
18551755
Cell. 2002 May 17;109(4):509-21
12086607
Cell. 1995 Jul 14;82(1):57-65
7606786
Leukemia. 2002 Nov;16(11):2309-17
12399977
Cancer. 2007 Dec 15;110(12):2672-81
17960614
Genes Chromosomes Cancer. 2000 Dec;29(4):363-6
11066083
Mol Biol Cell. 2000 Oct;11(10):3299-313
11029037
Mol Cell Biol. 2003 Jan;23(1):70-9
12482962
Nat Genet. 1995 Aug;10(4):436-44
7670494
Exp Cell Res. 2006 Apr 15;312(7):974-82
16430883
Oncol Rep. 2008 Oct;20(4):929-39
18813837
J Cell Sci. 2003 Apr 1;116(Pt 7):1359-66
12615977
Thorax. 2005 Jul;60(7):576-81
15994266
FEBS Lett. 1995 Oct 16;373(3):245-9
7589475
Genomics. 1996 Aug 15;36(1):118-29
8812423
Semin Cell Dev Biol. 2006 Apr;17(2):185-93
16765615
Mod Pathol. 2006 Aug;19(8):1108-16
16680155
J Biol Chem. 2003 Jan 24;278(4):2157-68
12441356
Genes Chromosomes Cancer. 1998 Jun;22(2):100-4
9598796
Nat Rev Mol Cell Biol. 2004 Nov;5(11):920-31
15520811
Development. 2000 May;127(10):2227-38
10769246
J Cell Biol. 2006 Jul 17;174(2):175-83
16831886
Traffic. 2003 Aug;4(8):503-11
12839493
BMC Cancer. 2007 Oct 23;7:198
17956604
J Hepatol. 2009 Mar;50(3):528-37
19155088
J Cell Biol. 2000 May 29;149(5):1073-86
10831611
Glia. 2001 Dec;36(3):375-90
11746774
Genome Res. 2003 Aug;13(8):1838-54
12869577
Nat Rev Cancer. 2007 Dec;7(12):899-910
18004397
FEBS Lett. 2004 Sep 10;574(1-3):1-8
15358530
J Cell Sci. 2006 Aug 15;119(Pt 16):3316-24
16868024
Acta Biochim Biophys Sin (Shanghai). 2009 Jan;41(1):63-8
19129951
Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):1834-9
14766979
J Biol Chem. 2001 Sep 14;276(37):34759-67
11395501
Genes Chromosomes Cancer. 2001 Aug;31(4):382-9
11433529
Eur J Pharmacol. 2009 Mar 15;606(1-3):172-9
19171136
Mol Biol Cell. 2000 Jan;11(1):117-29
10637295
J Cell Sci. 2002 Dec 15;115(Pt 24):4721-6
12432060
Circ Res. 2008 Jul 3;103(1):61-9
18511849
J Biol Chem. 2003 Apr 4;278(14):12175-81
12496242
Mol Biol Cell. 2008 Sep;19(9):3745-57
18579687
Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4465-70
11904358