Nitric oxide, lipid peroxidation, and antioxidant enzyme levels in epileptic children using valproic acid.
In the present study, we investigated the effects of valproic acid (VPA) on nitric oxide (NO) level, lipid peroxidation, and antioxidant enzyme activities in 21 epileptic children and 26 healthy controls. The subjects were selected from those who visited for a checkup or medical treatment at the Mustafa Kemal University Research Hospital. Serum levels of NO(-2), NO(-3), malondialdehyde (MDA), superoxide dismutase (SOD), and catalase (CAT) were analyzed by redox or enzymatic reactions and spectrophotometry. Based on the NO(-2) and NO(-3) levels, the NO concentration was about 10% higher in VPA group than in the control group (p<0.001). However, no significant difference was detected for serum MDA, SOD, and CAT levels. It is suggested that NO would play a role in the mechanism of antiepileptic effects by VPA treatment.
Peker
Erdal
E
Medical Faculty, Department of Pediatrics, Yuzuncu Yil University, 65100 Van, Turkey. pekererdal@hotmail.com
Oktar
Süleyman
S
Ari
Mustafa
M
Kozan
Ramazan
R
Doğan
Murat
M
Cağan
Eren
E
Söğüt
Sadik
S
D000927:Anticonvulsants / Q000494:pharmacology* / Q000627:therapeutic use; D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood; D002374:Catalase / Q000097:blood; D002648:Child; D002675:Child, Preschool; D057075:Enzyme Assays; D004798:Enzymes / Q000097:blood*; D004827:Epilepsy / Q000097:blood* / Q000151:congenital / Q000188:drug therapy*; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects / Q000502:physiology; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D009569:Nitric Oxide / Q000097:blood*; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology; D013053:Spectrophotometry; D013482:Superoxide Dismutase / Q000097:blood; D014635:Valproic Acid / Q000494:pharmacology* / Q000627:therapeutic use
D000927:Anticonvulsants; D000975:Antioxidants; D015415:Biomarkers; D004798:Enzymes; D009569:Nitric Oxide; D008315:Malondialdehyde; D014635:Valproic Acid; D002374:Catalase; D013482:Superoxide Dismutase