title: Regional cerebral blood volume ratio on perfusion MRI on the growth of infarct size in acute ischemic stroke.
abstract: We hypothesized that the relative regional cerebral blood volume (rCBV) ratio could help predict the risk of infarct growth on follow-up magnetic resonance imaging (MRI) in patients with diffusion perfusion mismatch (DPM) on the time-to-peak (TTP) map. We recruited 60 patients with acute middle cerebral arterial (MCA) infarction who had been evaluated by perfusion MRI within 24 h of initial ischemic events, and assessed the predictive role of the rCBV ratio on infarct growth in patients with DPM. Among 60 patients with acute MCA ischemic stroke, 41 (68.3%) patients had DPM on the initial MRI. Follow-up MRI revealed ischemic lesion enlargement in 19 (31.7%) of these 41 patients. The presence of DPM had no effect on the rate of lesion enlargement. Patients with ischemic lesion growth in follow-up images had a significantly lower rCBV ratio than patients without (0.81 +/- 0.22 vs. 1.08 +/- 0.20, p < 0.01). In this study, the decreased rCBV ratio on perfusion MRI has a predictive value for the growth of ischemic lesions after acute ischemic stroke with DPM on the TTP map.
authors.affiliation: Stroke Center, Dong-A University Hospital, Seo-Gu, Busan, Republic of Korea.
authors.forename: Su-Yun
authors.initials: SY
authors.lastname: Lee
authors.forename: Jae-Kwan
authors.initials: JK
authors.lastname: Cha
authors.forename: Myong-Jin
authors.initials: MJ
authors.lastname: Kang
mesh_terms: D000368:Aged; D001783:Blood Flow Velocity; D001921:Brain / Q000473:pathology*; D001931:Brain Mapping; D002560:Cerebrovascular Circulation; D018450:Disease Progression; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D020244:Infarction, Middle Cerebral Artery / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012189:Retrospective Studies