title: Guidelines for the treatment of bacterial vaginosis: focus on tinidazole.
abstract: Bacterial vaginosis (BV) is a complex vaginal infection most commonly associated with women of child-bearing age. Risk factors for BV are numerous. There are currently multiple clinical and laboratory tests for diagnosis of BV, including the most commonly used diagnostic methods: Amsel's criteria or Nugent's Gram stain scale. The mainstay of BV therapy is metronidazole, but tinidazole as well as a few other agents have also been used successfully. Tinidazole is the second nitroimidazole antiprotozoal agent and a structural derivative of metronidazole. With a favorable pharmacokinetic profile and reduced side effects, tinidazole is an alternative agent for BV treatment. There are minimal head-to-head comparative data to establish tinidazole's superiority to metronidazole or other therapeutic agents. Available data suggest tinidazole has a role in special populations particularly for refractory or relapsing BV.
authors.affiliation: Department of Pharmacy Services, Detroit Receiving Hospital, Detroit, MI, USA.
authors.forename: Laura J
authors.initials: LJ
authors.lastname: Dickey
authors.forename: Michael D
authors.initials: MD
authors.lastname: Nailor
authors.forename: Jack D
authors.initials: JD
authors.lastname: Sobel
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