Cholestane glycosides and trihydroxy fatty acids from the rhizomes of Dioscorea septemloba.
Two new steroidal glycosides, named dioseptemlosides I (1) and J (2), along with two known trihydroxy fatty acids, (12 Z,15 Z)-9,10,11-trihydroxy-12,15-octadecadienoic acid (3) and (12 Z)-9,10,11-trihydroxy-12-octadecenoic acid (4), were isolated from the rhizomes of Dioscorea septemloba. Their structures were determined by HRESIMS, 1D and 2D NMR experiments, physical data, and chemical methods. The antitumor activity of compounds 1-4 was evaluated against three tumor cell lines and all of them were inactive at a concentration of 10 microM.
Liu
Xue-Ting
XT
State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, PR China. liuxueting_cn@hotmail.com
Wang
Zhen-Zhong
ZZ
Xiao
Wei
W
Zhao
Hui-Wu
HW
Yu
Biao
B
D045744:Cell Line, Tumor; D002776:Cholestanes / Q000737:chemistry / Q000302:isolation & purification*; D027742:Dioscorea / Q000737:chemistry*; D005227:Fatty Acids / Q000737:chemistry / Q000302:isolation & purification*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification*; D006801:Humans; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry*; D027343:Rhizome
D002776:Cholestanes; D005227:Fatty Acids; D006027:Glycosides; D010936:Plant Extracts; C549780:dioseptemloside I; C549779:dioseptemloside J