APOBEC3B deletion and risk of HIV-1 acquisition.
The human APOBEC3 family of cytidine deaminases provides intrinsic immunity to retroviral infection. A naturally occurring 29.5-kb deletion removes the entire APOBEC3B gene. We examined the impact of the APOBEC3B gene deletion in >4000 individuals from 5 human immunodeficiency virus type 1 (HIV-1) natural history cohorts. The hemizygous genotype had no effect on either acquisition of HIV-1 infection or progression to AIDS. However, the homozygous deletion was significantly associated with unfavorable outcomes for HIV-1 acquisition (odds ratio, 7.37; P= .024), progression to AIDS (relative hazard, 4.01; P=. 03), and viral set point (P= .04). These findings suggest that the loss of APOBEC3B may increase host susceptibility to HIV-1 acquisition and progression to AIDS and warrant further study.
An
Ping
P
Laboratory of Genomic Diversity, SAIC-Frederick, National Cancer Institute-Frederick, Frederick, MD 21702, USA.
Johnson
Randall
R
Phair
John
J
Kirk
Gregory D
GD
Yu
Xiao-Fang
XF
Donfield
Sharyne
S
Buchbinder
Susan
S
Goedert
James J
JJ
Winkler
Cheryl A
CA
D003564:Cytidine Deaminase / Q000235:genetics*; D005006:Ethnicity; D017353:Gene Deletion; D005786:Gene Expression Regulation / Q000502:physiology; D020022:Genetic Predisposition to Disease; D015658:HIV Infections / Q000235:genetics*; D015497:HIV-1; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D015778:Minor Histocompatibility Antigens
D015778:Minor Histocompatibility Antigens; C495794:APOBEC3B protein, human; D003564:Cytidine Deaminase
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