Molecular evolution of novel swine-origin A/H1N1 influenza viruses among and before human.
We find that the novel A/H1N1 influenza viruses exhibit very low genetic divergence and suffer strong purifying selection among human population and confirm that they originated from the reassortment of previous triple-reassortant swine influenza viruses including genomic segments from both avian and human lineages with North American and Eurasian swine lineages. The longer phylogenetic branch length to their nearest genetic neighbors indicates that the origin of the novel A/H1N1 is unlikely to be a very recent event. Seventy-six new unique mutations are found to be monomorphically fixed in the novel A/H1N1 virus lineages, suggesting a role of selective sweep in the early evolution of this virus.
Ding
Na
N
Institute of Life Sciences, Jiangsu University, Jiangsu, China.
Wu
Nana
N
Xu
Qinggang
Q
Chen
Keping
K
Zhang
Chiyu
C
D000818:Animals; D016000:Cluster Analysis; D019143:Evolution, Molecular; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000235:genetics*; D007251:Influenza, Human / Q000821:virology; D009976:Orthomyxoviridae Infections / Q000821:virology; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics*; D016865:Reassortant Viruses / Q000235:genetics; D017385:Sequence Homology
D012367:RNA, Viral
Nucleic Acids Res. 2008 Jul 1;36(Web Server issue):W157-62
18515345
N Engl J Med. 2009 Jun 18;360(25):2605-15
19423869
Science. 2004 Mar 12;303(5664):1666-9
14752165
N Engl J Med. 2009 Jun 18;360(25):2616-25
19423871
Philos Trans R Soc Lond B Biol Sci. 2001 Dec 29;356(1416):1817-28
11779380
Mol Biol Evol. 2007 Aug;24(8):1586-91
17483113
Science. 2009 Jul 10;325(5937):197-201
19465683
N Engl J Med. 2008 Jan 17;358(3):261-73
18199865
Science. 2006 Apr 21;312(5772):394-7
16627737
Euro Surveill. 2009 Feb 19;14(7):
19232229
Mol Biol Evol. 2007 Aug;24(8):1596-9
17488738
Mol Biol Evol. 2005 Dec;22(12):2472-9
16107592
MMWR Morb Mortal Wkly Rep. 2009 Apr 24;58(15):400-2
19390508
Proc Natl Acad Sci U S A. 2005 Feb 15;102(7):2430-5
15695582
Microbiol Mol Biol Rev. 2008 Sep;72(3):457-70
18772285
Nature. 2009 Jun 25;459(7250):1122-5
19516283
BMC Microbiol. 2006 Oct 04;6:88
17020602
MMWR Morb Mortal Wkly Rep. 2009 May 8;58(17):467-70
19444150
EMBO J. 2005 Apr 20;24(8):1634-43
15791205
Emerg Infect Dis. 2008 Sep;14(9):1470-2
18760023
Vet Microbiol. 2009 Oct 20;139(1-2):132-9
19477087
Genetics. 2000 May;155(1):431-49
10790415