title: Whole-genome scan for guttural pouch tympany in Arabian and German warmblood horses.
abstract: Equine guttural pouch tympany (GPT) is a hereditary disease in foals of several breeds, including thoroughbreds, Arabian, Quarter and warmblood horses. We performed a whole-genome scan for GPT in 143 horses from five Arabian and five German warmblood families and genotyped 257 microsatellites. Chromosome-wide significant linkage was detected on ECA2 and ECA15 using multipoint non-parametric linkage analyses. Analyses stratified by sex revealed chromosome-wide significant linkage on ECA2 for fillies and chromosome-wide significant linkage on ECA15 for colts. For Arabian colts, the quantitative trait locus (QTL) on ECA15 was genome-wide significant. Haplotypes including two to four microsatellites within the QTL on ECA2 and 15 in fillies and colts, respectively, were significantly associated with GPT for both breeds. Thus, our analysis indicated sex-specific QTL, a fact which is in agreement with a two- to fourfold higher incidence of GPT in females. This is the first report of QTL for equine GPT and a first step towards identifying genes responsible for GPT.
authors.affiliation: Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Bünteweg 17p, 30559 Hannover, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Zeitz
authors.forename: A
authors.initials: A
authors.lastname: Spötter
authors.forename: I
authors.initials: I
authors.lastname: Blazyczek
authors.forename: U
authors.initials: U
authors.lastname: Diesterbeck
authors.forename: B
authors.initials: B
authors.lastname: Ohnesorge
authors.forename: E
authors.initials: E
authors.lastname: Deegen
authors.forename: O
authors.initials: O
authors.lastname: Distl
mesh_terms: D000818:Animals; D055106:Genome-Wide Association Study; D006734:Horse Diseases / Q000235:genetics*; D006736:Horses / Q000235:genetics; D008297:Male; D010375:Pedigree; D010608:Pharyngeal Diseases / Q000235:genetics / Q000662:veterinary*; D040641:Quantitative Trait Loci