Toxicodynamics of itraconazole: implications for therapeutic drug monitoring.
We explored concentration-toxicity relationships for itraconazole among 216 patients. Logistic regression revealed a progressive increase in the probability of toxicity with increasing concentrations of itraconazole. Classification and regression tree analysis suggested that 17.1 mg/L of itraconazole (measured using a bioassay) was the concentration level at which the population of patients was separated into 2 groups, each with a high and a low probability of toxicity.
Lestner
Jodi M
JM
The University of Manchester, Manchester Academic Health Science Centre, NIHR Translational Research Facility in Respiratory Medicine, University Hospital of South Manchester NHS Foundation Trust, Manchester, UK.
Roberts
Steven A
SA
Moore
Caroline B
CB
Howard
Susan J
SJ
Denning
David W
DW
Hope
William W
WW
D000935:Antifungal Agents / Q000009:adverse effects* / Q000097:blood / Q000493:pharmacokinetics / Q000627:therapeutic use; D001229:Aspergillosis, Allergic Bronchopulmonary / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D016903:Drug Monitoring; D005767:Gastrointestinal Diseases / Q000139:chemically induced*; D006801:Humans; D016867:Immunocompromised Host; D017964:Itraconazole / Q000009:adverse effects* / Q000097:blood / Q000493:pharmacokinetics / Q000627:therapeutic use; D016015:Logistic Models; D016377:Organ Transplantation; D055732:Pulmonary Aspergillosis / Q000188:drug therapy; D012372:ROC Curve; D016896:Treatment Outcome; D014882:Water-Electrolyte Balance / Q000187:drug effects*
D000935:Antifungal Agents; D017964:Itraconazole