title: Successful extracorporeal membranous oxygenation for a patient with life-threatening transfusion-related acute lung injury.
abstract: A case of transfusion-related acute lung injury (TRALI) that was successfully treated with extracorporeal membranous oxygenation (ECMO) is reported. A 58-year-old male patient underwent hepatectomy, and pulmonary edema occurred after the administration of fresh-frozen plasma and packed red cells. In the postoperative period, the impaired oxygenation progressively worsened, resulting in life-threatening hypoxemia, despite vigorous treatments. ECMO was therefore applied to the patient as a method of safe emergency support. Aggressive treatments under ECMO led to the successful improvement of the impaired oxygenation. TRALI is recognized as part of acute respiratory distress syndrome (ARDS). As a treatment for ARDS, ECMO does not cure the underlying disease of the lungs, however, with ECMO, TRALI, usually improves within 96 h with respiratory support. ECMO for TRALI-induced lethal hypoxemia is useful for providing time to allow the injured lung to recover. It is suggested that ECMO might be a useful option for the treatment of TRALI-induced, potentially lethal hypoxemia.
authors.affiliation: Department of Anesthesiology, Sapporo Medical University School of Medicine, Sapporo, Japan.
authors.forename: Hiromitsu
authors.initials: H
authors.lastname: Kuroda
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Masuda
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Imaizumi
authors.forename: Yuji
authors.initials: Y
authors.lastname: Kozuka
authors.forename: Yasufumi
authors.initials: Y
authors.lastname: Asai
authors.forename: Akiyoshi
authors.initials: A
authors.lastname: Namiki
mesh_terms: D000768:Anesthesia, General; D006528:Carcinoma, Hepatocellular / Q000601:surgery; D017707:Erythrocyte Transfusion / Q000009:adverse effects; D015199:Extracorporeal Membrane Oxygenation; D006498:Hepatectomy; D006801:Humans; D007431:Intraoperative Complications / Q000000981:diagnostic imaging / Q000628:therapy*; D008113:Liver Neoplasms / Q000601:surgery; D008171:Lung Diseases / Q000000981:diagnostic imaging / Q000209:etiology* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D010949:Plasma; D011175:Positive-Pressure Respiration; D011654:Pulmonary Edema / Q000209:etiology; D014057:Tomography, X-Ray Computed; D065227:Transfusion Reaction
chemical_list: D010100:Oxygen
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