title: Levels of circulating biomarkers at rest and after exercise in coronary artery disease patients.
abstract: As traditional risk factors are unable to fully explain the pathogenesis of coronary artery disease (CAD), novel mechanisms became a target of many investigations. Our aim was to study the response of selected markers to physical exercise. High-sensitive C-reactive protein (hs-CRP), matrix metalloproteinases 2 and 9 (MMP-2, MMP-9), advanced oxidation protein products (AOPP), soluble receptor for advanced glycation end-products (sRAGE), pregnancy-associated plasma protein A (PAPP-A), E-selectin, vascular endothelial growth factor (VEGF) and B-type natriuretic peptide (BNP) levels were measured in serum of 21 CAD patients and in 22 healthy controls at rest and after exercise bicycle stress test performed up to the maximal tolerated effort. At rest, hs-CRP, AOPP, MMP-9 and BNP were significantly elevated in the CAD patients as compared with controls. In contrast, P-selectin was significantly lower in CAD patients and a tendency to lower levels of sRAGE was noted. After exercise MMP-9 and BNP, increased significantly in both groups. In conclusions, CAD patients have elevated hs-CRP, AOPP, MMP-9 and BNP--novel markers related to cardiovascular risk or left ventricular overload. MMP-9 and BNP increase significantly with exercise in both healthy individuals and CAD patients.
authors.affiliation: Second Department of Medicine, First Faculty of Medicine, General University Hospital, Charles University, Prague, Czech Republic.
authors.forename: V
authors.initials: V
authors.lastname: Danzig
authors.forename: B
authors.initials: B
authors.lastname: Míková
authors.forename: P
authors.initials: P
authors.lastname: Kuchynka
authors.forename: H
authors.initials: H
authors.lastname: Benáková
authors.forename: T
authors.initials: T
authors.lastname: Zima
authors.forename: O
authors.initials: O
authors.lastname: Kittnar
authors.forename: J
authors.initials: J
authors.lastname: Skrha
authors.forename: A
authors.initials: A
authors.lastname: Linhart
authors.forename: M
authors.initials: M
authors.lastname: Kalousová
mesh_terms: D000328:Adult; D000368:Aged; D001642:Bicycling; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000097:blood* / Q000503:physiopathology*; D015444:Exercise; D005080:Exercise Test; D017079:Exercise Tolerance; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress
chemical_list: D015415:Biomarkers; D018836:Inflammation Mediators