Progression and prognosis of gastric stump cancer.
OBJECTIVE
The incidence of gastric stump cancer (GSC) is increasing. The aim of this study is to determine the clinicopathologic feature and the differences of surgical outcome between GSC after partial gastrectomy for benign diseases (GSC-B) and GSC after partial gastrectomy for malignant tumors (GSC-M).


METHODS
Medical records of 42 patients with GSC-B and 47 patients with GSC-M who underwent surgical treatment were studied and analyzed retrospectively. Clinicopathologic parameters, the 5-year survival rate after operation and prognostic factors, were analyzed retrospectively.


RESULTS
GSC was frequently detected in anastomotic site. Poorly differentiated cancer was common. No difference was found between patients with GSC-B and patients with GSC-M in terms of histologic type, tumor location, and distribution of tumor stage. GSC-B patients had a higher incidence in No. 7, 8, 9 lymph nodes than GSC-M patients. In contrast, the patients with GSC-M had higher incidence of metastasis to jejunal mesentery lymph nodes and No. 10, 11 lymph nodes. The overall 5-year survival rates were 38.1% for GSC-B and 10.4% for GSC-M, with significant difference (P < 0.05).


CONCLUSIONS
GSC has a particular pattern in lymph node metastasis and organs invasion. Surgical resection is considered an effective therapeutic strategy for GSC.
Hu
Xiang
X
Department of General Surgery, The First Affiliated Hospital, Dalian Medical University, Dalian 116011, China. yui79@hotmail.com
Tian
Da-Yu
DY
Cao
Liang
L
Yu
Yi
Y
Yi
Yu
Y
D000368:Aged; D002277:Carcinoma / Q000401:mortality / Q000473:pathology / Q000601:surgery; D016022:Case-Control Studies; D003106:Colon / Q000473:pathology; D005260:Female; D005743:Gastrectomy / Q000379:methods; D018530:Gastric Stump / Q000473:pathology*; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D010179:Pancreas / Q000473:pathology; D011379:Prognosis; D012189:Retrospective Studies; D013154:Spleen / Q000473:pathology; D013274:Stomach Neoplasms / Q000401:mortality* / Q000473:pathology* / Q000601:surgery; D015996:Survival Rate