title: Computerized cognitive assessment of mild cognitive impairment in urban African Americans.
abstract: Few objective cognitive assessment tools have been validated for mild cognitive impairment (MCI) in African Americans despite higher prevalence of disease. This preliminary study evaluated discriminant validity of a computerized cognitive assessment battery for MCI in an urban African American cohort. Twenty-seven participants with MCI and 22 cognitively healthy individuals completed a multidomain battery (Mindstreams, NeuroTrax Corp, New Jersey). Mild cognitive impairment participants performed more poorly than cognitively healthy participants in all domains, with significant differences in memory (P = .003; d = 0.96), executive function (P = .046; d = 0.64), and overall battery performance (P = .041; d = 0.63). Adjustment for intelligence quotient (IQ) yielded significant differences in memory (P < .001; d = 1.34), executive function (P = .007; d = 0.86), attention (P = .014; d = .80), and overall performance (P = .001; d = 1.09). Such a validated battery may help to address an important clinical need in this population.
authors.affiliation: Department of Clinical Science, NeuroTrax Corporation, Newark, New Jersey 07103, USA. glen.doniger@neurotrax.com
authors.forename: Glen M
authors.initials: GM
authors.lastname: Doniger
authors.forename: Mi-Yeoung
authors.initials: MY
authors.lastname: Jo
authors.forename: Ely S
authors.initials: ES
authors.lastname: Simon
authors.forename: Howard A
authors.initials: HA
authors.lastname: Crystal
mesh_terms: D000328:Adult; D001741:Black or African American / Q000706:statistics & numerical data; D000368:Aged; D003072:Cognition Disorders / Q000175:diagnosis* / Q000208:ethnology; D003936:Diagnosis, Computer-Assisted / Q000379:methods* / Q000592:standards; D005260:Female; D006801:Humans; D007361:Intelligence Tests; D008297:Male; D008568:Memory; D009483:Neuropsychological Tests; D015995:Prevalence; D015203:Reproducibility of Results; D012720:Severity of Illness Index; D012984:Software; D014505:Urban Population / Q000706:statistics & numerical data; D014706:Verbal Learning
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