Evidence-based medicine in the treatment of peritoneal carcinomatosis: Past, present, and future.
The current treatment of peritoneal surface malignancies (PSMs) is moving from a nihilistic approach, into a combined modality approach offering selected patients long-term survival. As primary PSM are rare, extrapolation of data from clinical trials of related disease is necessary to develop treatment guidelines. Secondary PSM are more common, and therefore, treatment guidelines should be developed based on prospective clinical trials. We reviewed the published and ongoing clinical trials studying the treatment of PSM.
Nissan
Aviram
A
Department of Surgery, Hadassah-Hebrew University Medical Center Mount Scopus, Jerusalem, Israel. anissan@hadassah.org.il
Stojadinovic
Alexander
A
Garofalo
Alfredo
A
Esquivel
Jesus
J
Piso
Pompiliu
P
D002986:Clinical Trials as Topic; D006801:Humans; D010534:Peritoneal Neoplasms / Q000628:therapy*