Reference values of urinary neutrophil gelatinase-associated lipocalin in very low birth weight infants.
In very low birth weight (VLBW) infants, acute renal impairment (ARI) is common, but there is no consensus about criteria for its diagnosis. Neutrophil gelatinase-associated lipocalin (NGAL) is an early and sensitive indicator of renal impairment in experimental animals, children, and adults. Urinary NGAL (UNGAL) is detectable in VLBW infants; however, there is no reference range in this population. The objective of this study is to define the reference range for UNGAL in VLBW infants with no risk factors for acute renal impairment. UNGAL concentration was determined in urine samples collected from day of life (DOL) 4 through DOL 30 in 50 newborns with uncomplicated clinical courses, selected from a total of 145 prospectively enrolled appropriate for gestational age inborn VLBW premature infants. The birth weight and gestational age ranges were 790-1490 g and 26-33 wk, respectively. The median, 95th and 99th percentiles, and range of pooled UNGAL values were 5 ng/mL, 50 ng/mL, 120 ng/mL, and 2-150 ng/mL, respectively. Greater variability and higher quantile levels of UNGAL were observed in females versus males. In conclusion, a reference range for UNGAL in VLBW infants, similar to that in children and adults, has been established.
Huynh
Trang K
TK
Division of Newborn Medicine, Department of Pediatrics, New York Presbyterian Hospital-Weill Cornell Medical College, New York, New York 10065, USA. trangkhuynh@yahoo.com
Bateman
David A
DA
Parravicini
Elvira
E
Lorenz
John M
JM
Nemerofsky
Sheri L
SL
Sise
Meghan E
ME
Bowman
Teresa M
TM
Polesana
Elena
E
Barasch
Jonathan M
JM
D000209:Acute-Phase Proteins / Q000652:urine*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight / Q000652:urine*; D007674:Kidney Diseases / Q000175:diagnosis / Q000652:urine; D000071068:Lipocalin-2; D054834:Lipocalins / Q000652:urine*; D008297:Male; D011446:Prospective Studies; D011518:Proto-Oncogene Proteins / Q000652:urine*; D012016:Reference Values; D012044:Regression Analysis; D012307:Risk Factors; D012737:Sex Factors; D013997:Time Factors
D000209:Acute-Phase Proteins; C489506:LCN2 protein, human; D000071068:Lipocalin-2; D054834:Lipocalins; D011518:Proto-Oncogene Proteins
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