title: Evaluating the mitochondrial timescale of human evolution.
abstract: Different methodologies and modes of calibration have produced disparate, sometimes irreconcilable, reconstructions of the evolutionary and demographic history of our species. We discuss how date estimates are affected by the choice of molecular data and methodology, and evaluate various mitochondrial estimates of the timescale of human evolution in the context of the contemporary palaeontological and archaeological evidence for key stages in human prehistory. We contend that some of the most widely-cited mitochondrial rate estimates have several significant shortcomings, including a reliance on a human-chimpanzee calibration, and highlight the pressing need for revised rate estimates.
authors.affiliation: Départment Hommes Natures Sociétés, Musée de l'Homme, Paris, France.
authors.forename: Phillip
authors.initials: P
authors.lastname: Endicott
authors.forename: Simon Y W
authors.initials: SY
authors.lastname: Ho
authors.forename: Mait
authors.initials: M
authors.lastname: Metspalu
authors.forename: Chris
authors.initials: C
authors.lastname: Stringer
mesh_terms: D005075:Biological Evolution; D004272:DNA, Mitochondrial / Q000737:chemistry; D019143:Evolution, Molecular; D005580:Fossils; D054629:Genome, Mitochondrial; D006801:Humans; D008928:Mitochondria / Q000235:genetics*; D010802:Phylogeny; D013997:Time Factors
chemical_list: D004272:DNA, Mitochondrial