title: Unusual intramolecular N-->O acyl group migration occurring during conjugation of (-)-DHMEQ with cysteine.
abstract: Previously we found that (-)-DHMEQ, a specific NF-kappaB inhibitor, covalently bound to a specific cysteine of NF-kappaB component proteins. In the course of formation of the (-)-DHMEQ and protected cysteine conjugate, we observed an unusual intramolecular N-->O acyl group migration.
authors.affiliation: Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan.
authors.forename: Ikuko
authors.initials: I
authors.lastname: Kozawa
authors.forename: Kuniki
authors.initials: K
authors.lastname: Kato
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Teruya
authors.forename: Kiyotake
authors.initials: K
authors.lastname: Suenaga
authors.forename: Kazuo
authors.initials: K
authors.lastname: Umezawa
mesh_terms: D001549:Benzamides / Q000378:metabolism*; D003512:Cyclohexanones / Q000378:metabolism*; D003545:Cysteine / Q000378:metabolism*; D008968:Molecular Conformation; D016328:NF-kappa B / Q000037:antagonists & inhibitors*
chemical_list: D001549:Benzamides; D003512:Cyclohexanones; D016328:NF-kappa B; C464444:dehydroxymethylepoxyquinomicin; D003545:Cysteine