Bacterial jailbreak sounds cellular alarm: phagosome membrane remnants trigger signaling.
Shigella flexneri and other invasive bacteria rupture the phagosome membrane and escape to the host cytoplasm. Now, Dupont et al. address the fate and signaling functions of pathogen vacuole remnants and show that these membrane fragments trigger host-cell-signaling responses, including polyubiquitination, autophagy, and pyroptosis.
Hilbi
Hubert
H
Institute of Zoology, University of Zurich, Winterthurerstrasse 190, Zurich CH-8057, Switzerland. hilbi@zool.uzh.ch
D001343:Autophagy; D002462:Cell Membrane / Q000378:metabolism*; D008954:Models, Biological; D010588:Phagosomes / Q000382:microbiology*; D012763:Shigella flexneri / Q000472:pathogenicity*; D015398:Signal Transduction; D054875:Ubiquitination