Parvovirus B19 induced hepatic failure in an adult requiring liver transplantation.
Parvovirus B19 induced acute hepatitis and hepatic failure have been previously reported, mainly in children. Very few cases of parvovirus induced hepatic failure have been reported in adults and fewer still have required liver transplantation. We report the case of a 55-year-old immunocompetent woman who developed fulminant hepatic failure after acute infection with Parvovirus B19 who subsequently underwent orthotopic liver transplantation. This is believed to be the first reported case in the literature in which an adult patient with fulminant hepatic failure associated with acute parvovirus B19 infection and without hematologic abnormalities has been identified prior to undergoing liver transplantation. This case suggests that Parvovirus B19 induced liver disease can affect adults, can occur in the absence of hematologic abnormalities and can be severe enough to require liver transplantation.
Krygier
Darin S
DS
Division of Gastroenterology, Department of Medicine, Vancouver General Hospital, Vancouver, BC V5Z 1M9, Canada.
Steinbrecher
Urs P
UP
Petric
Martin
M
Erb
Siegfried R
SR
Chung
Stephen W
SW
Scudamore
Charles H
CH
Buczkowski
Andrzej K
AK
Yoshida
Eric M
EM
D000208:Acute Disease; D004279:DNA, Viral / Q000378:metabolism; D005260:Female; D006505:Hepatitis / Q000628:therapy* / Q000821:virology*; D006801:Humans; D017114:Liver Failure, Acute / Q000628:therapy* / Q000821:virology*; D016031:Liver Transplantation / Q000379:methods*; D008875:Middle Aged; D010322:Parvoviridae Infections / Q000628:therapy* / Q000821:virology; D016732:Parvovirus B19, Human / Q000378:metabolism*; D016133:Polymerase Chain Reaction; D016896:Treatment Outcome
D004279:DNA, Viral
Am J Gastroenterol. 1998 Mar;93(3):468-70
9517662
Intern Med J. 2007 Mar;37(3):192-5
17316340
Rheum Dis Clin North Am. 1998 May;24(2):375-401
9606764
Lancet. 1996 Mar 30;347(9005):868-9
8622394
Arch Virol. 1999;144(9):1713-24
10542021
J Infect Chemother. 2000 Mar;6(1):63-4
11810534
Am J Gastroenterol. 1993 Sep;88(9):1463
8362857
Liver Transpl. 2008 Aug;14(8):1100-6
18668666
N Engl J Med. 2004 Feb 5;350(6):586-97
14762186
J Infect Dis. 2003 May 15;187(10):1581-6
12721938
Can J Gastroenterol. 2005 Mar;19(3):161-2
15776137
Hepatology. 1995 Dec;22(6):1661-5
7489971