Isolated skull base metastasis as the first manifestation of hepatocellular carcinoma--a rare case report with review of literature.
BACKGROUND
Hepatocellular carcinoma rarely metastasizes to skull base.


METHODS
We report an extremely rare case of solitary skull base metastasis without metastasis to any other site, with right third, fourth, and sixth cranial nerve palsy as the initial manifestation of the disease.


CONCLUSIONS
The biopsy specimen of skull base lytic lesion suggested metastatic hepatocellular carcinoma. Subsequent examination revealed a large mass involving superior segment of right lobe of liver, which was confirmed as hepatocellular carcinoma on histopathological examination.


CONCLUSIONS
Until now, there have been only 24 cases of hepatocellular carcinoma metastasizing to skull base cited in literature. We report here an unusual case of solitary skull base metastasis from hepatocellular carcinoma prior to the diagnosis of primary tumor.
Trivedi
Priti
P
Department of Pathology, The Gujarat Cancer & Research Institute, Ahmedabad, Gujarat, India. priti_patho@yahoo.co.in
Gupta
Anuja
A
Pasricha
Sunil
S
Agrawal
Gaurav
G
Shah
Manoj
M
D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000556:secondary*; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D019292:Skull Base Neoplasms / Q000473:pathology*
Hong Kong Med J. 2002 Feb;8(1):48-51
11861994
Radiology. 1986 Jul;160(1):175-8
3012630
Acta Neurochir (Wien). 2007 Feb;149(2):185-90
17180305
World J Gastroenterol. 2006 Nov 7;12(41):6727-9
17075993
HNO. 2001 Feb;49(2):126-9
11270194
J Neurol Neurosurg Psychiatry. 1992 Nov;55(11):1037-9
1335033
J Gastroenterol Hepatol. 1995 Jul-Aug;10(4):413-8
8527707
Taiwan Yi Xue Hui Za Zhi. 1979 Jun;78(6):594-604
226652
Korean J Gastroenterol. 2008 Dec;52(6):389-93
19096257
Eur J Neurol. 2007 Apr;14(4):408-12
17388989
Neurol Med Chir (Tokyo). 1985 Mar;25(3):229-34
2409470
Skull Base Surg. 2000;10(2):81-6
17171106
Eur J Gastroenterol Hepatol. 2001 Sep;13(9):1083-8
11564960
Radiology. 2000 Sep;216(3):698-703
10966697
Surg Neurol. 1985 Jan;23(1):41-8
2981120
Neurol Med Chir (Tokyo). 1993 Dec;33(12):839-44
7512232
Neurol Med Chir (Tokyo). 1992 Mar;32(3):166-8
1377801
J Surg Oncol. 1988 Sep;39(1):33-4
2843717
Bull Soc Med Afr Noire Lang Fr. 1968;13(3):577-85
4306564
Neurosurgery. 1990 May;26(5):863-6
2162018
J Neurol Neurosurg Psychiatry. 1981 Dec;44(12):1171-2
6278095
J Neurooncol. 2005 Oct;75(1):63-9
16215817