title: Anti-interleukin-2 receptor antibodies-basiliximab and daclizumab-for the prevention of acute rejection in renal transplantation.
abstract: The use of antibody induction after kidney transplantation has increased from 25% to 63% in the past decade and roughly one half of the induction agent used is anti-interleukin-2 receptor antibody (IL-2RA, ie, basiliximab or daclizumab). When combined with calcineurin inhibitor (CNI)-based immunosuppression, IL-2RAs have been shown to reduce the incidence of acute rejection, one of the predictors of poor graft survival, without increasing risks of infections and malignancies in kidney transplantation. For low-immunological-risk patients, IL-2RAs, as compared with lymphocyte-depleting antibodies, are equally efficacious and have better safety profiles. For high-risk patients, however, IL-2RAs may be inferior to lymphocyte-depleting antibodies for the prophylaxis of acute rejection. In an effort to reduce toxicities of other immunosuppressive medications without increasing the risk of acute rejection and chronic graft loss, IL-2RAs have often been combined with steroid- and CNI-sparing immunosuppression protocols. More data support the benefits of early steroid withdrawal with IL-2RA in low-risk patients, but preferred induction therapy for high-risk patients has yet to be determined. Although CNI-sparing protocols with IL-2RA may preserve renal function and improve long-term survival in selected patients, further studies are needed to identify those who benefit most from this strategy.
authors.affiliation: DeWitt Daughtry Family Department of Surgery, Division of Kidney and Pancreas Transplantation, Lillian Jean Kaplan Renal Transplant Center, University of Miami Leonard M. Miller School of Medicine, Miami, FL, USA.
authors.forename: Junichiro
authors.initials: J
authors.lastname: Sageshima
authors.forename: Gaetano
authors.initials: G
authors.lastname: Ciancio
authors.forename: Linda
authors.initials: L
authors.lastname: Chen
authors.forename: George W
authors.initials: GW
authors.lastname: Burke
references.citation: Transplantation. 2005 Apr 15;79(7):807-14
references.pmid: 15818323
references.citation: Transplantation. 2001 Oct 15;72(7):1261-7
references.pmid: 11602853
references.citation: Nephrol Dial Transplant. 2008 Feb;23(2):707-14
references.pmid: 17890244
references.citation: BMJ. 2003 Apr 12;326(7393):789
references.pmid: 12689974
references.citation: Am J Transplant. 2004 Apr;4(4):626-35
references.pmid: 15023156
references.citation: Transplant Proc. 2002 Aug;34(5):1730-2
references.pmid: 12176554
references.citation: Clin Transplant. 2007 May-Jun;21(3):295-300
references.pmid: 17488375
references.citation: Lancet. 2000 Oct 14;356(9238):1327-8
references.pmid: 11073027
references.citation: Transplantation. 2004 Aug 27;78(4):584-90
references.pmid: 15446319
references.citation: Transplantation. 2005 Aug 27;80(4):457-65
references.pmid: 16123718
references.citation: N Engl J Med. 2007 Dec 20;357(25):2562-75
references.pmid: 18094377
references.citation: Cochrane Database Syst Rev. 2009 Jan 21;(1):CD005632
references.pmid: 19160257
references.citation: Transpl Int. 2000;13(2):151-9
references.pmid: 10836653
references.citation: Clin Transplant. 2008 Mar-Apr;22(2):200-10
references.pmid: 18339140
references.citation: Transplantation. 2005 Dec 27;80(12):1734-41
references.pmid: 16378069
references.citation: Am J Transplant. 2007 Mar;7(3):560-70
references.pmid: 17229079
references.citation: Transplantation. 2005 Feb 15;79(3):344-8
references.pmid: 15699766
references.citation: Transplant Proc. 2004 May;36(4):1080-1
references.pmid: 15194375
references.citation: Transplant Proc. 2001 Feb-Mar;33(1-2):1011-2
references.pmid: 11267168
references.citation: N Engl J Med. 1998 Jan 15;338(3):161-5
references.pmid: 9428817
references.citation: Am J Transplant. 2004 Nov;4(11):1776-85
references.pmid: 15476476
references.citation: Clin Transplant. 2006 May-Jun;20(3):325-9
references.pmid: 16824149
references.citation: Transplant Proc. 2001 Aug;33(5):2767-9
references.pmid: 11498153
references.citation: Am J Kidney Dis. 2008 Jan;51(1 Suppl 1):S1-320
references.pmid: 18086389
references.citation: Transplantation. 2007 Apr 15;83(7):883-92
references.pmid: 17460558
references.citation: Transplantation. 2001 May 15;71(9):1282-7
references.pmid: 11397963
references.citation: Transplant Proc. 1999 Sep;31(6):2206-7
references.pmid: 10500546
references.citation: Clin Transplant. 2000 Oct;14(5):509-13
references.pmid: 11048998
references.citation: Transplantation. 2000 Nov 15;70(9):1352-9
references.pmid: 11087152
references.citation: Transplantation. 1991 Jan;51(1):107-13
references.pmid: 1846250
references.citation: Transplantation. 2004 Jan 27;77(2):166-76
references.pmid: 14742976
references.citation: N Engl J Med. 2005 Aug 25;353(8):770-81
references.pmid: 16120857
references.citation: Transplantation. 1999 Nov 27;68(10):1597-603
references.pmid: 10589961
references.citation: Transplant Proc. 2001 Nov-Dec;33(7-8):3184-6
references.pmid: 11750366
references.citation: Transplantation. 1994 Mar 27;57(6):857-9
references.pmid: 8154032
references.citation: Transplantation. 2001 Sep 15;72(5):845-50
references.pmid: 11571448
references.citation: Transplantation. 2002 Apr 15;73(7):1100-6
references.pmid: 11965039
references.citation: N Engl J Med. 2000 Mar 2;342(9):605-12
references.pmid: 10699159
references.citation: Am J Transplant. 2002 Jul;2(6):568-73
references.pmid: 12118902
references.citation: Transplantation. 2006 Dec 15;82(11):1533-6
references.pmid: 17164728
references.citation: Transpl Int. 2000;13(2):142-5
references.pmid: 10836651
references.citation: Am J Transplant. 2008 Feb;8(2):307-16
references.pmid: 18211506
references.citation: Clin Transplant. 2009 Jan-Feb;23(1):23-32
references.pmid: 18798851
references.citation: N Engl J Med. 2008 Oct 16;359(16):1736-8
references.pmid: 18923181
references.citation: Am J Transplant. 2004 May;4(5):803-10
references.pmid: 15084178
references.citation: Transplantation. 1997 Dec 27;64(12):1701-5
references.pmid: 9422405
references.citation: Clin Transplant. 2003 Aug;17(4):369-76
references.pmid: 12868995
references.citation: Transplant Proc. 2000 Jun;32(4):790-2
references.pmid: 10856587
references.citation: Transpl Int. 2007 Jan;20(1):27-36
references.pmid: 17181650
references.citation: Transplantation. 1989 Jan;47(1):55-9
references.pmid: 2643232
references.citation: Transplant Proc. 2002 Aug;34(5):1617-8
references.pmid: 12176508
references.citation: Transplantation. 1995 Aug 15;60(3):248-52
references.pmid: 7645037
references.citation: Am J Transplant. 2003 Mar;3(3):306-11
references.pmid: 12614286
references.citation: J Am Soc Nephrol. 2000 Oct;11(10):1903-1909
references.pmid: 11004222
references.citation: Lancet. 1997 Oct 25;350(9086):1193-8
references.pmid: 9652559
references.citation: Ann Surg. 2008 Oct;248(4):564-77
references.pmid: 18936569
references.citation: Mol Immunol. 2003 Jul;39(17-18):1083-8
references.pmid: 12835081
references.citation: Transplantation. 2004 Nov 27;78(10):1560-3
references.pmid: 15599323
references.citation: Transplantation. 2004 Nov 15;78(9):1332-40
references.pmid: 15548972
references.citation: Clin Transplant. 2001 Apr;15(2):123-30
references.pmid: 11264639
references.citation: Am J Transplant. 2003 Aug;3(8):1010-6
references.pmid: 12859538
references.citation: Transplant Proc. 2001 Feb-Mar;33(1-2):2032-3
references.pmid: 11267613
references.citation: Transplantation. 2000 Sep 15;70(5):784-90
references.pmid: 11003358
references.citation: Transplantation. 1993 Apr;55(4):752-6; discussion 756-7
references.pmid: 8475548
references.citation: Transplantation. 2007 Jul 15;84(1):75-82
references.pmid: 17627241
references.citation: Transplantation. 2006 Mar 27;81(6):832-9
references.pmid: 16570004
references.citation: Transplantation. 2005 Sep 27;80(6):807-14
references.pmid: 16210969
references.citation: Transplant Proc. 2001 Feb-Mar;33(1-2):1057-8
references.pmid: 11267189
references.citation: Transplantation. 2002 Oct 15;74(7):966-71
references.pmid: 12394838
references.citation: Am J Transplant. 2002 Jan;2(1):48-56
references.pmid: 12095056
references.citation: Transplant Proc. 2003 Mar;35(2):873-4
references.pmid: 12644172
references.citation: Clin Transplant. 2000 Dec;14(6):550-4
references.pmid: 11127307
references.citation: Am J Transplant. 2008 Mar;8(3):574-85
references.pmid: 18294153
references.citation: Am J Transplant. 2005 Aug;5(8):1976-85
references.pmid: 15996248
references.citation: Transplantation. 2001 Dec 27;72(12):1915-9
references.pmid: 11773888
references.citation: Am J Transplant. 2005 Jan;5(1):157-66
references.pmid: 15636625
references.citation: Transplantation. 1999 Nov 15;68(9):1288-94
references.pmid: 10573065
references.citation: Am J Transplant. 2003 Apr;3(4):416-23
references.pmid: 12694063
references.citation: Clin Transplant. 2003 Oct;17(5):428-32
references.pmid: 14703925
references.citation: Transplantation. 1999 Jan 15;67(1):110-5
references.pmid: 9921806
references.citation: Transplantation. 2001 May 15;71(9):1320-8
references.pmid: 11397971
references.citation: Transplantation. 1988 Jan;45(1):226-8
references.pmid: 3122385
references.citation: Transplantation. 1999 Jan 27;67(2):276-84
references.pmid: 10075594
references.citation: Transplantation. 2004 Nov 27;78(10):1548-56
references.pmid: 15599321
references.citation: Transplantation. 2008 Jul 15;86(1):67-74
references.pmid: 18622280
references.citation: Am J Transplant. 2006 May;6(5 Pt 1):1042-8
references.pmid: 16611342
references.citation: Transplantation. 2003 Jan 15;75(1):37-43
references.pmid: 12544868
references.citation: Am J Transplant. 2003 Jan;3(1):50-2
references.pmid: 12492710
references.citation: Transplant Proc. 2001 Feb-Mar;33(1-2):1013-4
references.pmid: 11267169
references.citation: Transplantation. 2001 Sep 15;72(5):839-45
references.pmid: 11571447
references.citation: Transplantation. 2001 Dec 27;72(12 Suppl):S75-80
references.pmid: 11833145
references.citation: Transplant Proc. 2005 Mar;37(2):802-3
references.pmid: 15848537
references.citation: Am J Transplant. 2006 Jul;6(7):1617-23
references.pmid: 16827862
references.citation: Transplantation. 2001 Nov 27;72(10):1709-10
references.pmid: 11726840
references.citation: Am J Transplant. 2005 Oct;5(10):2539-48
references.pmid: 16162205
references.citation: Transplantation. 2004 Aug 27;78(4):557-65
references.pmid: 15446315
references.citation: N Engl J Med. 2006 Nov 9;355(19):1967-77
references.pmid: 17093248
references.citation: Transplantation. 1999 Dec 27;68(12):1865-74
references.pmid: 10628766
references.citation: Transplantation. 1995 Oct 15;60(7):748-56
references.pmid: 7570988
references.citation: CMAJ. 1992 Sep 1;147(5):645-57
references.pmid: 1521210
references.citation: Transplantation. 1997 Jan 15;63(1):33-8
references.pmid: 9000657