Neurod1 is essential for the survival and maturation of adult-born neurons.
The transcriptional program that controls adult neurogenesis is unknown. We generated mice with an inducible stem cell-specific deletion of Neurod1, resulting in substantially fewer newborn neurons in the hippocampus and olfactory bulb. Thus, Neurod1 is cell-intrinsically required for the survival and maturation of adult-born neurons.
Gao
Zhengliang
Z
Department of Molecular Biology and Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Ure
Kerstin
K
Ables
Jessica L
JL
Lagace
Diane C
DC
Nave
Klaus-Armin
KA
Goebbels
Sandra
S
Eisch
Amelia J
AJ
Hsieh
Jenny
J
D053687:Adult Stem Cells / Q000502:physiology*; D000818:Animals; D001253:Astrocytes / Q000502:physiology; D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics / Q000378:metabolism*; D002454:Cell Differentiation / Q000502:physiology; D002470:Cell Survival / Q000502:physiology; D002478:Cells, Cultured; D006624:Hippocampus / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D055495:Neurogenesis / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D009830:Olfactory Bulb / Q000502:physiology*; D013997:Time Factors
D051792:Basic Helix-Loop-Helix Proteins; C501008:Neurod1 protein, mouse
J Neurosci. 2000 Aug 15;20(16):6095-105
10934259
Neuron. 2004 May 27;42(4):535-52
15157417
J Neurosci. 2007 Nov 14;27(46):12623-9
18003841
Genes Dev. 1997 Sep 15;11(18):2323-34
9308961
J Neurosci. 2000 May 15;20(10):3714-24
10804213
Neuroreport. 2000 Jun 26;11(9):1991-6
10884058
Science. 1995 May 12;268(5212):836-44
7754368
Prog Neurobiol. 2007 Sep;83(1):37-52
17517461
Neuron. 2004 Jan 22;41(2):229-41
14741104
Genesis. 2005 Aug;42(4):247-52
16028233
Nat Neurosci. 2009 Sep;12(9):1097-105
19701198
Genes Dev. 1995 Apr 15;9(8):1009-19
7774807