Obesity and thromboembolic disease.
Various abnormalities of hemostasis have been described in obesity, mainly concerning increased levels of plasminogen activator inhibitor-1, but other abnormalities of coagulation and platelet activation have been reported as well. Circulating microparticles have also been observed in obese patients. These suggest that obesity would be a risk factor for venous thromboembolism (VTE). Analysis of the database of the National Hospital Discharge Survey showed compelling evidence that obesity is, in fact, a risk factor for VTE. Obesity is also a risk factor for recurrent VTE. A synergistic effect of oral contraceptives with obesity has been shown.
Stein
Paul D
PD
Department of Research, St. Joseph Mercy Oakland Hospital, Pontiac, MI 48341-5023, USA. steinp@trinity-health.org
Goldman
Jose
J
D006487:Hemostasis / Q000502:physiology; D006801:Humans; D009765:Obesity / Q000150:complications* / Q000503:physiopathology* / Q000628:therapy; D011655:Pulmonary Embolism / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D020246:Venous Thrombosis / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy