title: Encapsulating peritoneal sclerosis in patients on peritoneal dialysis in Slovenia.
abstract: Encapsulating peritoneal sclerosis (EPS) is a rare complication in patients on peritoneal dialysis (PD), the prevalence of which increases with the time spent on PD. Various causative factors have been proposed, but the pathogenesis still remains unclear. The aim of our retrospective study was to analyze the basic clinical characteristics and outcomes of five patients diagnosed with EPS out of 423 patients treated with PD between January 1983 and December 2003. One patient was admitted due to ultrafiltration failure of the peritoneal membrane, and four patients were admitted for acute peritonitis. All of our patients presented with clinical symptoms suggestive of obstructive ileus. We confirmed the diagnosis of EPS with a computer tomography scan, a diagnostic laparotomy or laparoscopy, and a biopsy of the parietal peritoneum. We treated all of our patients with catheter removal, transferal to hemodialysis, antibiotics, complete parenteral nutrition, methylprednisolone, and tamoxifen for 6 months. One patient was treated with surgical enterolysis and died of septic complications, another patient died of sudden cardiac death during treatment. Three patients were doing well for 4-7 months after the treatment was started. The incidence of EPS was 1.2% and the mortality rate was 40%. EPS is a rare complication in longstanding PD patients in our institution. Despite treatment with hemodialysis, complete parenteral nutrition, steroids, tamoxifen and surgical intervention, the mortality rate is high and comparable to other reports.
authors.affiliation: Department of Nephrology, University Medical Center Ljubljana, SI-1000 Ljubljana, Slovenia. jelka.lindic@kclj.si
authors.forename: Jelka
authors.initials: J
authors.lastname: Lindic
authors.forename: Alijana Trost
authors.initials: AT
authors.lastname: Rupnik
authors.forename: Janez
authors.initials: J
authors.lastname: Tomazic
authors.forename: Andrej
authors.initials: A
authors.lastname: Skoberne
authors.forename: Andrej
authors.initials: A
authors.lastname: Gucek
authors.forename: Dusan
authors.initials: D
authors.lastname: Ferluga
authors.forename: Tadeja
authors.initials: T
authors.lastname: Pintar
authors.forename: Andreja
authors.initials: A
authors.lastname: Ales
authors.forename: Damjan
authors.initials: D
authors.lastname: Kovac
authors.forename: Radoslav
authors.initials: R
authors.lastname: Kveder
authors.forename: Jernej
authors.initials: J
authors.lastname: Pajek
authors.forename: Barbara
authors.initials: B
authors.lastname: Savicki-Ponikvar
authors.forename: Andrej
authors.initials: A
authors.lastname: Bren
mesh_terms: D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis / Q000009:adverse effects*; D010532:Peritoneal Diseases / Q000209:etiology* / Q000401:mortality / Q000628:therapy; D010537:Peritoneum / Q000473:pathology; D012189:Retrospective Studies; D012598:Sclerosis / Q000209:etiology* / Q000401:mortality / Q000628:therapy; D017524:Slovenia / Q000453:epidemiology; D055815:Young Adult