title: Modulation and transmission of sweet taste information for energy homeostasis.
abstract: Perception of sweet taste is important for animals to detect external energy source of calories. In mice, sweet-sensitive cells possess a leptin receptor. Increase of plasma leptin with increasing internal energy storage in the adipose tissue suppresses sweet taste responses via this receptor. Data from our recent studies indicate that leptin may also modulate sweet taste sensation in humans with a diurnal variation in sweet sensitivity. This leptin modulation of sweet taste information to the brain may influence individuals' preference and ingestive behavior, thereby playing important roles in regulation of energy homeostasis.
authors.affiliation: Section of Oral Neuroscience, Kyushu University, Graduate School of Dental Sciences, Fukuoka, Japan.
authors.forename: Keisuke
authors.initials: K
authors.lastname: Sanematsu
authors.forename: Nao
authors.initials: N
authors.lastname: Horio
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Murata
authors.forename: Ryusuke
authors.initials: R
authors.lastname: Yoshida
authors.forename: Tadahiro
authors.initials: T
authors.lastname: Ohkuri
authors.forename: Noriatsu
authors.initials: N
authors.lastname: Shigemura
authors.forename: Yuzo
authors.initials: Y
authors.lastname: Ninomiya
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D006706:Homeostasis; D006801:Humans; D007328:Insulin / Q000097:blood*; D020738:Leptin / Q000502:physiology*; D051379:Mice; D013649:Taste
chemical_list: D001786:Blood Glucose; D007328:Insulin; D020738:Leptin