title: Case presentation: xenograft resistance to protease degradation in a vasculitic ulcer.
abstract: Vasculitic ulcers are related to numerous underlying etiologies including autoimmune disease, rheumatoid arthritis and other inflammatory conditions.The resulting ulcerations are associated with high levels of pain, inflammation and tissue necrosis. Current therapies, including surgical intervention, are limited by the underlying inflammatory process and complications secondary to the wound etiology. conservative care has been relatively unsuccessful in promoting wound closure.This case presentations reviews the successful results of using a xenograft in the treatment of an inflammatory ulcer associated with cryoglobulinemia and vasculitis. Product integrity was maintained postoperatively, compared to an allograft, thereby allowing the wound treatment site to progress to closure.The type of cross linkage of acellular grafts may have a direct effect on product stability and treatment outcomes.
authors.affiliation: University of California, San Diego, CA, USA. gmulder@ucsd.edu
authors.forename: Gerit
authors.initials: G
authors.lastname: Mulder
authors.forename: Daniel K
authors.initials: DK
authors.lastname: Lee
mesh_terms: D003449:Cryoglobulinemia / Q000150:complications; D003646:Debridement / Q000379:methods*; D005500:Follow-Up Studies; D016523:Foot Ulcer / Q000209:etiology / Q000473:pathology / Q000601:surgery*; D006085:Graft Survival; D006801:Humans; D008297:Male; D008875:Middle Aged; D010447:Peptide Hydrolases / Q000378:metabolism*; D014183:Transplantation, Heterologous; D014657:Vasculitis / Q000150:complications* / Q000473:pathology / Q000601:surgery; D014945:Wound Healing
chemical_list: D010447:Peptide Hydrolases