Scan quality effect on glaucoma discrimination by glaucoma imaging devices.
OBJECTIVE
To evaluate, within ocular imaging scans of acceptable quality as determined by manufacturers' guidelines, the effects of image quality on glaucoma discrimination capabilities.


METHODS
One hundred and four healthy and 75 glaucomatous eyes from the Advanced Imaging in Glaucoma Study (AIGS) were imaged with GDx-VCC, HRT II and StratusOCT. Quality score (QS>/=8), pixel standard deviation (SD</=50) and signal strength (SS>/=5) were used as quality parameter cut-offs, respectively. GDx nerve fibre indicator (NFI) and HRT Moorfields regression analysis (MRA) classifications and OCT mean retinal nerve fibre layer (RNFL) thickness were used as the discriminatory parameters. Logistic regression models were used to model the dichotomous clinical classification (healthy vs glaucoma) as a function of image-quality parameters and discriminatory parameters.


RESULTS
Quality parameter covariates were statistically non-significant for GDx and HRT but had an inverse effect on OCT in predicting disease (a higher SS had a lower probability of glaucoma). Age was a significant covariate for GDx and HRT, but not OCT, while ethnicity and interaction between the image quality and the institute where scans were acquired were significant covariates in the OCT models.


CONCLUSIONS
Scan quality within the range recommended as acceptable by the manufacturer of each imaging device does not affect the glaucoma discriminating ability of GDx or HRT but does affect Stratus OCT glaucoma discrimination.
Sung
K R
KR
UPMC Eye Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, 203 Lothrop Street, Eye and Ear Institute, Suite 816, Pittsburgh, PA 15213, USA. schumanjs@upmc.edu
Wollstein
G
G
Schuman
J S
JS
Bilonick
R A
RA
Ishikawa
H
H
Townsend
K A
KA
Kagemann
L
L
Gabriele
M L
ML
D000328:Adult; D000368:Aged; D005260:Female; D005901:Glaucoma / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009887:Ophthalmoscopy / Q000592:standards; D057109:Scanning Laser Polarimetry / Q000592:standards; D041623:Tomography, Optical Coherence / Q000592:standards; D014794:Visual Fields
Surv Ophthalmol. 2008 Nov;53 Suppl1:S3-10
19038621
Invest Ophthalmol Vis Sci. 2006 May;47(5):2006-10
16639009
Ophthalmology. 2006 Feb;113(2):285-93
16406542
Arch Ophthalmol. 1997 Aug;115(8):983-90
9258219
Br J Ophthalmol. 2006 Feb;90(2):186-90
16424531
Ophthalmology. 2004 Oct;111(10):1860-5
15465547
Ophthalmology. 2006 Jun;113(6):985-991
16751039
Invest Ophthalmol Vis Sci. 2006 Oct;47(10):4254-61
17003413
Am J Ophthalmol. 2005 Jan;139(1):18-29
15652824
Invest Ophthalmol Vis Sci. 2003 Sep;44(9):3783-9
12939292
Ophthalmology. 2008 Jan;115(1):85-93
17629563
Ophthalmology. 2006 Sep;113(9):1613-7
16828504
Ophthalmology. 2005 Dec;112(12):2157-63
16290196
Invest Ophthalmol Vis Sci. 2006 Mar;47(3):1008-15
16505035
Br J Ophthalmol. 2005 Nov;89(11):1427-32
16234446
Invest Ophthalmol Vis Sci. 2006 Jul;47(7):2782-8
16799014
Ophthalmology. 2008 Apr;115(4):673-7
17719642
Am J Ophthalmol. 2003 Jul;136(1):26-33
12834666
Am J Ophthalmol. 2004 Aug;138(2):218-25
15289130
Arch Ophthalmol. 2004 Jun;122(6):827-37
15197057