title: Expression of the decay-accelerating factor (CD55) in renal transplants--a possible prediction marker of allograft survival.
abstract: BACKGROUND
  Decay-accelerating factor (CD55) accelerates the decay of C3 and C5 convertases, participating in classical and alternative complement activation pathways. Complement activation plays a major role in antibody-mediated rejection of allografts (AMR); C4d is used as a marker of AMR. Emerging evidence suggests an important role of CD55 in the pathogenesis of AMR. The aim of this study was to investigate the expression of CD55 in renal allografts and to correlate it with the expression of C4d, allograft survival, changes in serum creatinine (SC).
  
  
  METHODS
  More than 200 renal allograft biopsies, performed for allograft dysfunction, were assessed for peritubular capillary (PTC) C4d and CD55 expression.
  
  
  RESULTS
  We found significant correlation between changes in SC and PTC CD55 staining pattern in patients with no PTC C4d staining. In these patients, SC increased from baseline by 2.2+0.34, 1.7+0.36, and 0.93+0.24 mg/dL in negative, focal, and diffuse PTC CD55 staining subgroups, respectively. Survival of renal allografts was better in diffuse PTC CD55 staining subgroup than in negative PTC CD55 staining subgroup.
  
  
  CONCLUSIONS
  These data suggest that CD55 expression has a protective effect on PTC C4d negative renal allografts, and the pattern of PTC CD55 expression may be used as a potential marker of renal allograft survival in patients with no evidence of AMR.
authors.affiliation: Department of Pathology, The Ohio State University, Columbus, OH 43210, USA.
authors.forename: Sergey V
authors.initials: SV
authors.lastname: Brodsky
authors.forename: Gyongyi M
authors.initials: GM
authors.lastname: Nadasdy
authors.forename: Ronald
authors.initials: R
authors.lastname: Pelletier
authors.forename: Anjali
authors.initials: A
authors.lastname: Satoskar
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Birmingham
authors.forename: Gregg A
authors.initials: GA
authors.lastname: Hadley
authors.forename: Khaled
authors.initials: K
authors.lastname: Obeidat
authors.forename: Tibor
authors.initials: T
authors.lastname: Nadasdy
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D018958:CD55 Antigens / Q000378:metabolism*; D002196:Capillaries / Q000276:immunology; D015935:Complement C4b / Q000378:metabolism; D003170:Complement Pathway, Alternative; D005260:Female; D006085:Graft Survival / Q000276:immunology*; D006801:Humans; D007150:Immunohistochemistry; D007518:Isoantibodies / Q000378:metabolism; D053208:Kaplan-Meier Estimate; D007668:Kidney / Q000098:blood supply / Q000276:immunology / Q000473:pathology; D016030:Kidney Transplantation / Q000276:immunology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000378:metabolism; D014184:Transplantation, Homologous
chemical_list: D015415:Biomarkers; D018958:CD55 Antigens; D007518:Isoantibodies; D010446:Peptide Fragments; D015935:Complement C4b; C032261:complement C4d