Gender differences relating to metabolic syndrome and proinflammation in Finnish subjects with elevated blood pressure.
Fasting insulin, adiponectin, high-sensitivity C-reactive protein (hs-CRP), and interleukin-1 receptor antagonist (IL-1Ra) were determined in 278 men and 273 women with blood pressure > or = 130 and/or > or = 85 mmHg and/or with antihypertensive medication. Metabolic syndrome (MetS) with the National Cholesterol Education Program (NCEP) criteria was observed in 35% of men and 34% of women. Men with MetS had lower hs-CRP and IL-1Ra than women. The absolute gender difference in adiponectin was smaller and those in IL-1Ra and hs-CRP were greater in subjects with MetS compared to those without. After adjustment with body mass index the association between insulin and the odd's ratio (OR) for MetS remained significant in both genders, in females also the association between the OR for MetS and adiponectin. There are gender differences in subjects with elevated blood pressure and MetS with respect to inflammatory markers and the relationship between adiponectin levels and MetS.
Ahonen
Tiina
T
Palokka Health Center, 40270 Jyväskylä, Finland. tiina.ahonen@fimnet.fi
Saltevo
Juha
J
Laakso
Markku
M
Kautiainen
Hannu
H
Kumpusalo
Esko
E
Vanhala
Mauno
M
D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D001794:Blood Pressure / Q000502:physiology*; D002097:C-Reactive Protein / Q000378:metabolism; D005260:Female; D005387:Finland; D006801:Humans; D007249:Inflammation / Q000378:metabolism / Q000503:physiopathology; D007328:Insulin / Q000097:blood; D053590:Interleukin 1 Receptor Antagonist Protein / Q000378:metabolism; D053583:Interleukin-1beta / Q000276:immunology; D008297:Male; D024821:Metabolic Syndrome / Q000378:metabolism / Q000503:physiopathology; D008875:Middle Aged; D016017:Odds Ratio; D012737:Sex Factors
D015415:Biomarkers; D007328:Insulin; D053590:Interleukin 1 Receptor Antagonist Protein; D053583:Interleukin-1beta; D002097:C-Reactive Protein
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