Diversity synthesis of pyrimido[4,5-b][1,6]naphthyridine and its derivatives under microwave irradiation.
A series of new heterocyclic compounds, involving pyrimido[4,5-b][1,6]-, benzo[b][1,6]-, pyrazolo[3,4-b][1,6]naphthyridine, and aza-benzo[b]fluorene skeletons were successfully synthesized via the reaction of structurally diverse 3,5-dibenzylidenepiperidin-4-one with various enamine-likes (2,6-diaminopyrimidin-4(3H)-one, 3-amino-5,5-dimethylcyclohex-2-enone, 3-methyl-1-phenyl-1H-pyrazol-5-amine and 1H-benzo[d]imidazol-2-amine) in glycol under microwave irradiation. This method has the advantages of short synthetic route, operational simplicity, and increased safety for small-scale fast synthesis for biomedical screening.
Han
Zheng-Guo
ZG
School of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou, Jiangsu, 221116, PR China.
Zhang
Ge
G
Jiang
Bo
B
Ma
Ning
N
Shi
Feng
F
Tu
Shu-Jiang
SJ
D008872:Microwaves; D008958:Models, Molecular; D015394:Molecular Structure; D009287:Naphthyridines / Q000138:chemical synthesis* / Q000737:chemistry
D009287:Naphthyridines; C545233:pyrimido(4,5-b)(1,6)naphthyridine