Coenzyme Q10 improves diastolic function in children with idiopathic dilated cardiomyopathy.
We aimed to determine the effect of supplementation with coenzyme Q10 on conventional therapy of children with cardiac failure due to idiopathic dilated cardiomyopathy. In a prospective, randomized, double-blinded, placebo-controlled trial, we randomized 38 patients younger than 18 years with idiopathic dilated cardiomyopathy to receive either coenzyme Q10, chosen for 17 patients, or placebo, administered in the remaining 21. Echocardiographic systolic and diastolic function parameters were determined for every patient at baseline, and after 6 months of supplementation. The index score for cardiac failure in children as established in New York was used for assessing the functional class of the patients. After 6 months supplementation, 10 patients randomized to receive coenzyme Q10 showed improvements in the grading of diastolic function, this being significantly more than that achieved by those randomized to the placebo group (p value = 0.011). The mean score for the index of cardiac failure index for those receiving coenzyme Q10 was also lower than the control group (p value = 0.024).Our results, therefore, indicate that administration of coenzyme Q10 is useful in ameliorating cardiac failure in patients with idiopathic dilated cardiomyopathy through its significant effect on improving diastolic function.
Kocharian
Armen
A
Department of Pediatric Cardiology, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
Shabanian
Reza
R
Rafiei-Khorgami
Mohammad
M
Kiani
Abdolrazagh
A
Heidari-Bateni
Giv
G
D000293:Adolescent; D002311:Cardiomyopathy, Dilated / Q000150:complications*; D002648:Child; D002675:Child, Preschool; D004311:Double-Blind Method; D006333:Heart Failure / Q000188:drug therapy* / Q000209:etiology*; D006801:Humans; D007223:Infant; D011446:Prospective Studies; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D014815:Vitamins / Q000627:therapeutic use*
D014815:Vitamins; D014451:Ubiquinone; C024989:coenzyme Q10