The evaluation of doxepin concentrations in postmortem blood as optional cause of death.
The problems concerning an unstable data basis with regard to lethal Doxepin concentrations have been manifested based on a case about a 39-year-old man, who was found dead in his apartment with strangulation marks on his neck, for which a lethal Doxepin intoxication entered the differential diagnosis discussion. For a long time it has been known that postmortem redistribution leads to a falsely inflated concentration as measured in cardiac blood, while the concentrations in peripheral postmortem blood change comparatively little. Despite this, most of the current literature relies on published case report, which fails to mention the location of blood sampling, whereby it is fairly safe to assume that a central sample is intended. Only 9 cases of an isolated lethal Doxepin intoxication have been found, in which the concentrations in blood samples from peripheral vessels had been measured. These values lie between 1.5 and 7.0 mg/L, which is in the lowest quarter of the span of lethal concentrations mentioned in literature without specific mention of the location of the blood sample.
Dettling
Andrea
A
Institute of forensic and traffic medicine, University of Heidelberg, Vossstr, Heidelberg. andrea_dettling@med.uni-heidelberg.de
Haffner
Hans-Thomas
HT
Wehner
Heinz-Dieter
HD
D000328:Adult; D000929:Antidepressive Agents, Tricyclic / Q000097:blood*; D002851:Chromatography, High Pressure Liquid; D004316:Doxepin / Q000097:blood*; D049429:Forensic Pathology; D053593:Forensic Toxicology; D006801:Humans; D008297:Male; D019838:Neck Injuries / Q000473:pathology; D053120:Respiratory Aspiration / Q000473:pathology
D000929:Antidepressive Agents, Tricyclic; D004316:Doxepin