title: Computing power of quantitative trait locus association mapping for haploid loci.
abstract: BACKGROUND
  Statistical power calculations are a critical part of any study design for gene mapping. Most calculations assume that the locus of interest is biallelic. However, there are common situations in human genetics such as X-linked loci in males where the locus is haploid. The purpose of this work is to mathematically derive the biometric model for haploid loci, and to compute power for QTL mapping when the loci are haploid.
  
  
  RESULTS
  We have derived the biometric model for power calculations for haploid loci and have developed software to perform these calculations. We have verified our calculations with independent mathematical methods.
  
  
  CONCLUSIONS
  Our results fill a need in power calculations for QTL mapping studies. Furthermore, failure to appropriately model haploid loci may cause underestimation of power.
authors.affiliation: Department of Genetics, Rutgers University, 145 Bevier Road, Piscataway, NJ 08854, USA. gordon@biology.rutgers.edu
authors.forename: Derek
authors.initials: D
authors.lastname: Gordon
authors.forename: Andrew R
authors.initials: AR
authors.lastname: Zinn
mesh_terms: D002874:Chromosome Mapping / Q000379:methods*; D003198:Computer Simulation; D006238:Haploidy; D006801:Humans; D008297:Male; D040641:Quantitative Trait Loci
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