title: Continuous positive airway pressure deepens sleep in patients with Alzheimer's disease and obstructive sleep apnea.
abstract: OBJECTIVE
  Patients with Alzheimer's disease (AD) and obstructive sleep apnea (OSA) experience disrupted sleep. This study examined the effect of continuous positive airway pressure (CPAP) on sleep parameters in AD patients with OSA.
  
  
  METHODS
  A randomized placebo-controlled trial of 3 weeks of therapeutic CPAP (tCPAP) vs. 3 weeks placebo CPAP (pCPAP) followed by 3 weeks tCPAP in patients with AD and OSA. Polysomnography data from screening after one night and after 3 weeks of treatment were analyzed. Records were scored for percent of each sleep stage, total sleep time (TST), sleep efficiency (SE), sleep period (SP), time in bed (TIB), sleep onset (SO), wake time after sleep onset (WASO), and arousals. A randomized design comparing one night of pCPAP to tCPAP and a paired analysis combining 3 weeks of tCPAP were performed.
  
  
  RESULTS
  Fifty-two participants (mean age=77.8 years, SD=7.3) with AD and OSA were included. After one treatment night, the tCPAP group had significantly less % Stage 1 (p=0.04) and more % Stage 2 sleep (p=0.02) when compared to the pCPAP group. In the paired analysis, 3 weeks of tCPAP resulted in significant decreases in WASO (p=0.005), % Stage 1 (p=0.001), arousals (p=0.005), and an increase in % Stage 3 (p=0.006).
  
  
  CONCLUSIONS
  In mild to moderate AD patients with OSA, the use of tCPAP resulted in deeper sleep after just one night, with improvements maintained for 3 weeks.
authors.affiliation: Department of Medicine, University of California San Diego, La Jolla, Ca 92093-0733, USA.
authors.forename: Jana R
authors.initials: JR
authors.lastname: Cooke
authors.forename: Sonia
authors.initials: S
authors.lastname: Ancoli-Israel
authors.forename: Lianqi
authors.initials: L
authors.lastname: Liu
authors.forename: Jose S
authors.initials: JS
authors.lastname: Loredo
authors.forename: Loki
authors.initials: L
authors.lastname: Natarajan
authors.forename: Barton S
authors.initials: BS
authors.lastname: Palmer
authors.forename: Feng
authors.initials: F
authors.lastname: He
authors.forename: Jody
authors.initials: J
authors.lastname: Corey-Bloom
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000503:physiopathology / Q000628:therapy*; D001143:Arousal / Q000502:physiology; D002940:Circadian Rhythm / Q000502:physiology; D015897:Comorbidity; D045422:Continuous Positive Airway Pressure; D005260:Female; D006801:Humans; D008297:Male; D017286:Polysomnography; D020181:Sleep Apnea, Obstructive / Q000503:physiopathology / Q000628:therapy*; D012894:Sleep Stages / Q000502:physiology*; D012895:Sleep, REM / Q000502:physiology; D013997:Time Factors; D016896:Treatment Outcome
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