title: In vitro studies on the relationship between the  anti-inflammatory activity of Physalis peruviana  extracts and the phagocytic process.
abstract: The study of plants used in traditional medicine has drawn the attention of researchers as an alternative in the development of new therapeutics agents, such as the American Solanaceae Physalis peruviana, which has significant anti-inflammatory activity. The Physalis peruviana anti-inflammatory effect of ethanol or ether calyces extracts on the phagocytic process was assessed by using an in vitro phagocytosis model (Leishmania panamensis infection to murine macrophages). The Physalis peruviana extracts do not inhibit microorganism internalization and have no parasiticide effect. Most ET and EP extracts negatively affected the parasite's invasion of macrophages (Infected cells increased.). This observation might result from a down-regulation of the macrophage's microbicide ability associated with a selective reduction of proinflammatory cytokines levels. Physalis peruviana's anti-inflammatory activity described in this model is related to an immunomodulatory effect exerted on macrophages infected, which directly or indirectly "blocks" their ability to secrete soluble proinflammatory mediators.
authors.affiliation: Immunotoxicology Research Group, Science Faculty, National University of Colombia, Bogotá, Colombia.
authors.forename: Willington
authors.initials: W
authors.lastname: Martínez
authors.forename: Luis Fernando
authors.initials: LF
authors.lastname: Ospina
authors.forename: Diana
authors.initials: D
authors.lastname: Granados
authors.forename: Gabriela
authors.initials: G
authors.lastname: Delgado
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D002460:Cell Line; D007891:Leishmania / Q000276:immunology; D008264:Macrophages / Q000276:immunology / Q000469:parasitology; D051379:Mice; D010587:Phagocytosis / Q000187:drug effects*; D032321:Physalis; D010936:Plant Extracts / Q000494:pharmacology*
chemical_list: D000893:Anti-Inflammatory Agents; D010936:Plant Extracts