title: Poly(ethylene glycol)-stabilized silver nanoparticles for bioanalytical applications of SERS spectroscopy.
abstract: The present work depicts the efficient one-step synthesis and detailed evaluation of stable aqueous colloids of silver nanoparticles (NPs) coated with poly(ethylene glycol) (PEG) covalently attached to their surface. Due to steric repulsion between polymer-modified surfaces, the stability of the nanoparticle suspension was preserved even at high ionic strength (0.1 M NaCl). At the same time, the PEG coating remains sufficiently permeable to allow surface-enhanced Raman scattering (SERS) from micromolar concentrations of small molecules such as the anticancer drug mitoxantrone (MTX). The enhancement efficiency of the hot spot-free Ag-PEG was compared to that of citrate-stabilized Ag colloids used after pre-aggregation. The potential of the polymer-stabilized colloids developed in this study is discussed in terms of bioanalytical applications of SERS spectroscopy.
authors.affiliation: EA 4244, Physicochimie des matériaux et des biomolécules, groupe Nanovecteurs magnétiques pour la chimiothérapie, Université F. Rabelais, Faculté de Pharmacie, 31 avenue Monge, F-37200 Tours, France.
authors.forename: Andriy
authors.initials: A
authors.lastname: Shkilnyy
authors.forename: Martin
authors.initials: M
authors.lastname: Soucé
authors.forename: Pierre
authors.initials: P
authors.lastname: Dubois
authors.forename: Fabienne
authors.initials: F
authors.lastname: Warmont
authors.forename: Marie-Louise
authors.initials: ML
authors.lastname: Saboungi
authors.forename: Igor
authors.initials: I
authors.lastname: Chourpa
mesh_terms: D003102:Colloids / Q000737:chemistry; D053768:Metal Nanoparticles / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D008942:Mitoxantrone / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry*; D012834:Silver / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D013059:Spectrum Analysis, Raman / Q000379:methods*; D020349:Surface Plasmon Resonance
chemical_list: D003102:Colloids; D012834:Silver; D011092:Polyethylene Glycols; D008942:Mitoxantrone