Structural polymorphism of the mannose-binding lectin 2 (MBL2 ) gene in HCV-infected patients with a serological marker for thyroid autoimmunity.
We studied the association of the mannose-binding lectin-2 (MBL2) polymorphism with anti-thyroid antibodies (ATA) in hepatitis C virus (HCV)-infected Brazilian patients (n = 162) and 124 healthy volunteers screened for ATA. Our results showed that patients with ATA had higher frequency of genotype 00 than controls. MBL may play a role as disease modifier in HCV infection.
Melo
F M
FM
Postgraduate Program in Tropical Medicine, Federal University of Pernambuco (UFPE), Pernambuco, Brazil.
Vasconcelos
L R S
LR
Silva
B S
BS
Moura
P
P
Cavalcanti
M S M
MS
Pereira
L M M B
LM
Lacerda
H R
HR
D000293:Adolescent; D000328:Adult; D000368:Aged; D015551:Autoimmunity / Q000235:genetics*; D001938:Brazil; D016022:Case-Control Studies; D005260:Female; D016174:Hepacivirus / Q000276:immunology*; D006526:Hepatitis C / Q000097:blood* / Q000235:genetics; D006801:Humans; D008297:Male; D037601:Mannose-Binding Lectin / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic; D013961:Thyroid Gland / Q000276:immunology*
C445619:MBL2 protein, human; D037601:Mannose-Binding Lectin