Total antioxidant capacity and total oxidant status in patients with major depression: impact of antidepressant treatment.
OBJECTIVE
The purpose of the present study was to investigate whether total antioxidant capacity (TAC) and total oxidant status (TOS) are associated with major depressive disorder (MDD) and to evaluate the impact of antidepressant treatment on TAC and TOS in MDD.


METHODS
Fifty-seven MDD patients and 40 healthy controls participated in the study. Serum TAC and TOS were measured both in patients and controls using Erel's methods. Patients were treated with antidepressant drugs for 12 weeks. The treatment course was evaluated using the Montgomery-Asberg Depression Rating Scale (MADRS) in all patients.


RESULTS
TOS and oxidative stress index (OSI) were higher (P = 0.0001 for both) and TAC was lower (P = 0.0001) in the MDD group compared with those of the controls. After 3 months of antidepressant treatment, TOS and OSI were decreased and TAC was increased compared with the pretreatment values (P = 0.0001, for all). Furthermore, there were significant positive correlations between the severity of the disease and serum TOS and OSI (r = 0.584, P = 0.0001; r = 0.636, P = 0.0001, respectively). A negative correlation was found between the severity of the disease and serum TAC (r = -0.553, P = 0.0001) at the pre-treatment stage.


CONCLUSIONS
Treatment administered for 3 months to MDD patients increases TAC while decreasing TOS and OSI.
Cumurcu
Birgul Elbozan
BE
Department of Psychiatry, Gaziosmanpasa University School of Medicine, Tokat, Turkey. bcumurcu@gop.edu.tr
Ozyurt
Huseyin
H
Etikan
Ilker
I
Demir
Suleyman
S
Karlidag
Rifat
R
D000328:Adult; D016022:Case-Control Studies; D003865:Major Depressive Disorder / Q000097:blood* / Q000188:drug therapy; D005260:Female; D006801:Humans; D008297:Male; D016877:Oxidants / Q000097:blood*; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000187:drug effects*; D017382:Reactive Oxygen Species / Q000097:blood*; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology*; D012720:Severity of Illness Index; D013997:Time Factors
D016877:Oxidants; D017382:Reactive Oxygen Species; D017367:Selective Serotonin Reuptake Inhibitors