Synthesis of 1,2,4-triazine derivatives as potential anti-anxiety and anti-inflammatory agents.
A series of 1,2,4-triazine derivatives Va (1-24) and Vb (1-24) were synthesized and evaluated for their anti-anxiety and anti-inflammatory activities. The structures of the synthesized compounds were confirmed on the basis of their spectral data. Many of the triazine compounds were found to possess good activity. Especially, compounds bearing the sulfur atom showed better activity than those bearing the oxygen atom.
Mullick
Pooja
P
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard (Hamdard University) Hamdard Nagar, New Delhi-1 10062, India. poojamullick7@rediffmail.com
Khan
Suroor A
SA
Begum
Tauseef
T
Verma
Surajpal
S
Kaushik
Darpan
D
Alam
Ozair
O
D000818:Animals; D014151:Anti-Anxiety Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006835:Hydrazones / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology; D051381:Rats; D013329:Structure-Activity Relationship; D014227:Triazines / Q000138:chemical synthesis* / Q000494:pharmacology
D014151:Anti-Anxiety Agents; D000893:Anti-Inflammatory Agents; D006835:Hydrazones; D014227:Triazines; C093444:1,2,4-triazine