title: Temporal lobectomy: resection volume, neuropsychological effects, and seizure outcome.
abstract: OBJECTIVE
  The goal of the work described here was to evaluate relationships among resection volume, seizure outcome, and cognitive morbidity after temporal lobectomy for intractable epilepsy.
  
  
  METHODS
  Thirty patients with mesial temporal sclerosis were evaluated pre- and postoperatively with the Wechsler Adult Intelligence Scale III, Wechsler Memory Scale III, and three-dimensional coronal spoiled gradient recall acquisition MRI. Preoperative whole-brain volumes were calculated with Statistical Parametric Mapping. Resection volume was calculated by manual tracing. Systat was used for statistical analysis.
  
  
  RESULTS
  All resections included the temporal tip, at least 1cm of the superior temporal gyrus, and 3 to 5cm of the middle and inferior temporal gyri. Left were significantly smaller than right temporal resections. Seizure-free patients had significantly larger resections. Immediate verbal memory was significantly worse after left temporal lobectomy. Surgical outcome and resection volume did not affect postoperative neuropsychological results.
  
  
  CONCLUSIONS
  Dominant temporal lobe resections are associated with immediate verbal memory deficits. Larger resection volume was associated with improved seizure control but not worse cognitive outcome.
authors.affiliation: Clinical Epilepsy Section, NINDS, NIH, Bethesda, MD, USA.
authors.forename: Sadat
authors.initials: S
authors.lastname: Shamim
authors.forename: Edythe
authors.initials: E
authors.lastname: Wiggs
authors.forename: John
authors.initials: J
authors.lastname: Heiss
authors.forename: Susumu
authors.initials: S
authors.lastname: Sato
authors.forename: Clarissa
authors.initials: C
authors.lastname: Liew
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Solomon
authors.forename: William H
authors.initials: WH
authors.lastname: Theodore
mesh_terms: D000161:Acoustic Stimulation; D000293:Adolescent; D000328:Adult; D038481:Anterior Temporal Lobectomy / Q000379:methods*; D004569:Electroencephalography / Q000379:methods; D004833:Epilepsy, Temporal Lobe / Q000503:physiopathology / Q000523:psychology / Q000601:surgery; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007360:Intelligence / Q000502:physiology*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008568:Memory / Q000502:physiology*; D008875:Middle Aged; D009483:Neuropsychological Tests; D011184:Postoperative Period; D016896:Treatment Outcome; D055815:Young Adult
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