Out of the box binding determines specificity of SH2 domain interaction.
SH2 domains are phosphotyrosine specific interaction modules with largely overlapping sequence specificities. A recent structure by Bae et al. revealed that SH2 domain specificity can be mediated by secondary binding sites located outside the phosphotyrosine binding pocket.
Müller
Susanne
S
Knapp
Stefan
S
D001665:Binding Sites / Q000235:genetics; D009154:Mutation; D019000:Phosphotyrosine / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D011485:Protein Binding; D015398:Signal Transduction; D018909:src Homology Domains
D019000:Phosphotyrosine
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