Imaging of macroaneurysms occurring during retinal vein occlusion and diabetic retinopathy by indocyanine green angiography and high resolution optical coherence tomography.
BACKGROUND
Macular edema occurring after retinal vein occlusion (RVO) or diabetic retinopathy (DR) may be due to the development of capillary and/or venous macroaneurysms (MAs). Here, we investigated the respective contribution of fluorescein angiography (FA), of indocyanine green angiography (ICGA) and of high-resolution optical coherence tomography (HR-OCT) to their detection.


METHODS
Review of the charts of six consecutive patients with MAs secondary to RVO (n = 4) or DR (n = 2). For each patient, FA, ICGA and HR-OCT data were analyzed and compared.


RESULTS
All detectable MAs were detected by ICGA, while in three eyes FA failed to show them. Overall, ICGA provided a better delineation of MAs than FA. In all cases, HR-OCT identified MAs under the form of a vascular structure with a reflective wall surrounding a lumen containing variably reflective material.


CONCLUSIONS
MAs can develop during the course of RVO and DR. ICGA and HR-OCT improves the identification of capillary and venous MAs, and may thus be of interest to better identify sites of blood-retinal barrier rupture during chronic macular edema due to RVO or DR.
Bourhis
Alexandre
A
Department of Ophthalmology of the Fondation Ophtalmologique Rothschild, Université Pierre et Marie Curie Paris6, 75019 Paris, France.
Girmens
Jean-François
JF
Boni
Severin
S
Pecha
Florence
F
Favard
Catherine
C
Sahel
José-Alain
JA
Paques
Michel
M
D000368:Aged; D000783:Aneurysm / Q000209:etiology / Q000473:pathology*; D000792:Angiography / Q000379:methods*; D004396:Coloring Agents; D003930:Diabetic Retinopathy / Q000150:complications / Q000473:pathology*; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D007208:Indocyanine Green; D007834:Lasers; D008269:Macular Edema / Q000209:etiology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D019721:Ophthalmoscopes; D012170:Retinal Vein Occlusion / Q000150:complications / Q000473:pathology*; D012171:Retinal Vessels / Q000473:pathology; D041623:Tomography, Optical Coherence / Q000379:methods*
D004396:Coloring Agents; D007208:Indocyanine Green
Ophthalmic Physiol Opt. 2008 Jan;28(1):21-8
18201332
Acta Ophthalmol Scand. 1998 Dec;76(6):671-4
9881549
Am J Ophthalmol. 1998 Aug;126(2):238-47
9727518
Am J Ophthalmol. 2000 Jan;129(1):33-7
10653410
Klin Monbl Augenheilkd. 1995 Dec;207(6):372-6
8583749
Surv Ophthalmol. 2000 Jul-Aug;45(1):15-27
10946079
Ophthalmologica. 1997;211(2):115-8
9097320
Int Ophthalmol. 1997;21(3):161-4
9587834
Br J Ophthalmol. 1981 Jan;65(1):36-41
7192568
Am J Ophthalmol. 1990 May 15;109(5):567-70
2333919
Ann Ophthalmol. 1984 May;16(5):464-8
6742685
Ophthalmologica. 1995;209(5):248-50
8570146