title: The temporal course of mucoperiosteal flap revascularization at guided bone regeneration-treated implant sites: a pilot study.
abstract: OBJECTIVE
  To investigate post-operative capillary density regeneration in healing mucoperiosteal flaps at guided bone regeneration-treated implant sites.
  
  
  METHODS
  A non-invasive post-operative investigation was performed in 10 patients using orthogonal polarization spectral (OPS) imaging for assessment of capillary density during the course of mucoperiosteal flap wound healing for 6 weeks in patients receiving dental implants.
  
  
  RESULTS
  The greatest increase in capillary regeneration occurred in the early wound-healing phase, during weeks 1 and 2, and recovery to baseline was achieved between weeks 4 and 5. A comparison of adjacent OPS measurements indicated that differences between the time point immediately following administration of local anaesthesia and directly post-operatively ( p=0.002), between a directly post-operative time point and after 1 week (p=0.009), and between post-operative weeks 1 and 2 (p=0.036) were statistically significant.
  
  
  CONCLUSIONS
  The early healing phase of mucoperiosteal flaps is characterized by rapid capillary regeneration. OPS imaging enabled the possibility to monitor and quantify the temporal development of mucoperiosteal flap revascularization following periodontal surgery.
authors.affiliation: Department of Translational Physiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. d.m.milstein@amc.uva.nl
authors.forename: Dan M J
authors.initials: DM
authors.lastname: Milstein
authors.forename: Keshen R
authors.initials: KR
authors.lastname: Mathura
authors.forename: Jérôme A H
authors.initials: JA
authors.lastname: Lindeboom
authors.forename: Dewkoemar
authors.initials: D
authors.lastname: Ramsoekh
authors.forename: Robert
authors.initials: R
authors.lastname: Lindeboom
authors.forename: Can
authors.initials: C
authors.lastname: Ince
mesh_terms: D000328:Adult; D016301:Alveolar Bone Loss / Q000601:surgery; D001672:Biocompatible Materials; D001861:Bone Regeneration / Q000502:physiology*; D016025:Bone Transplantation; D002196:Capillaries / Q000254:growth & development; D003094:Collagen; D003758:Dental Implantation, Endosseous; D015921:Dental Implants; D005260:Female; D005500:Follow-Up Studies; D005881:Gingiva / Q000098:blood supply; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008567:Membranes, Artificial; D008859:Microscopy, Polarization; D018919:Neovascularization, Physiologic / Q000502:physiology*; D010483:Periapical Diseases / Q000601:surgery; D010865:Pilot Projects; D011446:Prospective Studies; D013524:Surgical Flaps / Q000098:blood supply*; D013997:Time Factors; D020390:Tooth Socket / Q000601:surgery; D014945:Wound Healing / Q000502:physiology
chemical_list: C106416:Bio-Gide; D001672:Biocompatible Materials; D015921:Dental Implants; D008567:Membranes, Artificial; D003094:Collagen