title: Hair as a novel noninvasive method to study the impact of pregnancy on CYP2D6 metabolizing capacity.
abstract: A novel method is described to investigate changes in the drug metabolizing capacity of CYP2D6 during pregnancy using hair analysis.
authors.affiliation: Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto, Ontario, Canada. lobrien14@gmail.com
authors.forename: Lisa
authors.initials: L
authors.lastname: O'Brien
authors.forename: Carina
authors.initials: C
authors.lastname: Baumer
authors.forename: Detlef
authors.initials: D
authors.lastname: Thieme
authors.forename: Hans
authors.initials: H
authors.lastname: Sachs
authors.forename: Gideon
authors.initials: G
authors.lastname: Koren
mesh_terms: D019943:Amino Acid Substitution; D019389:Cytochrome P-450 CYP2D6 / Q000235:genetics* / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D016903:Drug Monitoring; D005260:Female; D020440:Gene Duplication; D005838:Genotype; D006197:Hair / Q000378:metabolism*; D006200:Hair Color / Q000235:genetics*; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate / Q000235:genetics; D016297:Mutagenesis, Site-Directed; D004364:Pharmaceutical Preparations; D010641:Phenotype; D011247:Pregnancy; D011248:Pregnancy Complications; D013379:Substrate Specificity / Q000235:genetics
chemical_list: D004364:Pharmaceutical Preparations; D019389:Cytochrome P-450 CYP2D6