Intracranial recording and source localization of auditory brain responses elicited at the 50 ms latency in three children aged from 3 to 16 years.
Maturational studies of the auditory-evoked brain response at the 50 ms latency provide an insight into why this response is aberrant in a number of psychiatric disorders that have developmental origin. Here, using intracranial recordings we found that neuronal activity of the primary contributors to this response can be localised at the lateral part of Heschl's gyrus already at the age of 3.5 years. This study provides results to support the notion that deviations in cognitive function(s) attributed to the auditory P50 in adults might involve abnormalities in neuronal activity of the frontal lobe or in the interaction between the frontal and temporal lobes. Validation and localisation of progenitors of the adults' P50 in young children is a much-needed step in the understanding of the biological significance of different subcomponents that comprise the auditory P50 in the adult brain. In combination with other approaches investigating neuronal mechanisms of auditory P50, the present results contribute to the greater understanding of what and why neuronal activity underlying this response is aberrant in a number of brain dysfunctions. Moreover, the present source localisation results of auditory response at the 50 ms latency might be useful in paediatric neurosurgery practice.
Korzyukov
Oleg
O
Carman and Ann Adams Department of Pediatrics, Children's Hospital of Michigan, Wayne State University, Detroit, MI 48201, USA. okorzyuk@med.wayne.edu
Asano
Eishi
E
Gumenyuk
Valentina
V
Juhász
Csaba
C
Wagner
Michael
M
Rothermel
Robert D
RD
Chugani
Harry T
HT
D000161:Acoustic Stimulation; D000293:Adolescent; D001306:Auditory Pathways / Q000502:physiology*; D001307:Auditory Perception / Q000502:physiology; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000502:physiology*; D002648:Child; D002675:Child, Preschool; D004569:Electroencephalography; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D012815:Signal Processing, Computer-Assisted; D013017:Sound Localization / Q000502:physiology
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