A case of nephrotic syndrome in a patient with Churg-Strauss syndrome.
Renal involvement in Churg-Strauss syndrome (CSS) is not uncommon, but nephrotic syndrome is rarely reported in patients with CSS. A 25-year-old woman with a long history of bronchial asthma presented to our hospital with a chief complaint of generalized edema. Laboratory studies revealed normocytic normochromic anemia, marked eosinophilia, positive anti-neutrophil cytoplasmic antibody, hypoalbuminemia, and hypercholesterolemia. Urinalysis showed heavy proteinuria (4+) without significant casts. The 24-hour urinary protein excretion was 6.5 g with a selective index of 0.35. Echocardiography and X-ray of the paranasal sinuses suggested restrictive cardiomyopathy and maxillary sinusitis, respectively. Diagnoses of CSS and nephrotic syndrome were made on the basis of clinical and laboratory findings. Renal biopsy was performed, and pathologic findings revealed focal segmental glomerulosclerosis with mesangiolysis. The patient's clinical symptoms and proteinuria improved markedly after combined treatment with corticosteroids and cyclophosphamide. Herein, we report a case of nephrotic syndrome in a patient with CSS.
Park
Sun Young
SY
Department of Internal Medicine, College of Medicine, Brain Korea 21, Yonsei University, 134 Shinchon-Dong Seodaemoon-Gu, Seoul, 120-752, Korea.
Chang
Jae Hyun
JH
Kim
Hyun-Wook
HW
Kim
Dong Ki
DK
Kim
Eun Young
EY
Park
Jung Tak
JT
Chang
Tae Ik
TI
Park
Jung Won
JW
Jeong
Hyeon Joo
HJ
Han
Dae-Suk
DS
Kang
Shin-Wook
SW
D000328:Adult; D015267:Churg-Strauss Syndrome / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D003520:Cyclophosphamide / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D005920:Glomerular Mesangium / Q000648:ultrastructure; D005923:Glomerulosclerosis, Focal Segmental / Q000150:complications / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D009404:Nephrotic Syndrome / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D011239:Prednisolone / Q000627:therapeutic use; D011507:Proteinuria / Q000150:complications / Q000188:drug therapy / Q000473:pathology; D020551:Pulse Therapy, Drug; D016896:Treatment Outcome
D007166:Immunosuppressive Agents; D003520:Cyclophosphamide; D011239:Prednisolone
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