Genome-wide location analysis reveals a role for Sub1 in RNA polymerase III transcription.
Human PC4 and the yeast ortholog Sub1 have multiple functions in RNA polymerase II transcription. Genome-wide mapping revealed that Sub1 is present on Pol III-transcribed genes. Sub1 was found to interact with components of the Pol III transcription system and to stimulate the initiation and reinitiation steps in a system reconstituted with all recombinant factors. Sub1 was required for optimal Pol III gene transcription in exponentially growing cells.
Tavenet
Arounie
A
Commissariat à l'Energie Atomique, Institut de Biologie et de Technologies de Saclay, F-91101 Gif sur Yvette, France.
Suleau
Audrey
A
Dubreuil
Géraldine
G
Ferrari
Roberto
R
Ducrot
Cécile
C
Michaut
Magali
M
Aude
Jean-Christophe
JC
Dieci
Giorgio
G
Lefebvre
Olivier
O
Conesa
Christine
C
Acker
Joël
J
D026481:Blotting, Far-Western; D047369:Chromatin Immunoprecipitation; D002874:Chromosome Mapping; D015825:Chromosomes, Fungal / Q000235:genetics; D004271:DNA, Fungal / Q000235:genetics / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000235:genetics* / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D015966:Gene Expression Regulation, Fungal; D016681:Genome, Fungal; D009154:Mutation; D020411:Oligonucleotide Array Sequence Analysis; D011485:Protein Binding; D012320:RNA Polymerase III / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000254:growth & development / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics* / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism; D019474:Transcription Factors, TFIII / Q000378:metabolism; D014158:Transcription, Genetic; D000098832:Transcription Factor TFIIIC
D004271:DNA, Fungal; D004268:DNA-Binding Proteins; C101206:SUB1 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors; D019474:Transcription Factors, TFIII; D000098832:Transcription Factor TFIIIC; D012320:RNA Polymerase III
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