title: Hoffmann's syndrome: a case report.
abstract: This syndrome is characterized by the presence of hypothyroidism with myxoedema, muscle stiffness and pseudo hypertrophy. We describe the disorder in a 21 year old male, who got admitted with complaints of generalized weakness, cold intolerance, constipation, and hoarse voice, difficulty in walking and progressive enlargement of muscles of thighs and back with crampy pains for two years. Examination revealed mild mental retardation, enlarged tongue, dry and rough skin, enlargement of thighs and back muscles, motor weakness in flexors of hips and knees with delayed relaxation of deep tendon reflexes. Investigations revealed evidence of hypothyroidism with marked elevation of muscle enzymes. Following institution of replacement therapy with thyroxine, the patient showed marked clinical and biochemical improvements after six months, but insignificant decrease in muscle mass. In this report we review relevant literature.
authors.affiliation: SMHS Hospital, Srinagar, Kashmir, India.
authors.forename: Waseem
authors.initials: W
authors.lastname: Qureshi
authors.forename: Ghulam
authors.initials: G
authors.lastname: Hassan
authors.forename: Ghulam Qadir
authors.initials: GQ
authors.lastname: Khan
authors.forename: Syed Manzoor
authors.initials: SM
authors.lastname: Kadri
authors.forename: Manish
authors.initials: M
authors.lastname: Kak
authors.forename: Manzoor
authors.initials: M
authors.lastname: Ahmad
authors.forename: Shahid
authors.initials: S
authors.lastname: Tak
authors.forename: Darshan Lal
authors.initials: DL
authors.lastname: Kundal
authors.forename: Showkat
authors.initials: S
authors.lastname: Hussain
authors.forename: Abdul Rashid
authors.initials: AR
authors.lastname: Rather
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Masoodi
authors.forename: Sabia
authors.initials: S
authors.lastname: Sikander
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