title: Cellular morphogenesis in silico.
abstract: We describe a model that simulates spherical cells of different types that can migrate and interact either attractively or repulsively. We find that both expected morphologies and previously unreported patterns spontaneously self-assemble. Among the newly discovered patterns are a segmented state of alternating discs, and a "shish-kebab" state, in which one cell type forms a ring around a second type. We show that these unique states result from cellular attraction that increases with distance (e.g., as membranes stretch viscoelastically), and would not be seen in traditional, e.g., molecular, potentials that diminish with distance. Most of the states found computationally have been observed in vitro, and it remains to be established what role these self-assembled states may play in in vivo morphogenesis.
authors.affiliation: Department of Biomedical Engineering, Rutgers University, Piscataway, New Jersey 08854, USA. shinbrot@soemail.rutgers.edu
authors.forename: Troy
authors.initials: T
authors.lastname: Shinbrot
authors.forename: Young
authors.initials: Y
authors.lastname: Chun
authors.forename: Carlos
authors.initials: C
authors.lastname: Caicedo-Carvajal
authors.forename: Ramsey
authors.initials: R
authors.lastname: Foty
mesh_terms: D000818:Animals; D002450:Cell Communication / Q000502:physiology*; D002465:Cell Movement; D048429:Cell Size; D003198:Computer Simulation; D006801:Humans; D008954:Models, Biological; D009024:Morphogenesis / Q000502:physiology*
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