title: [Natural history of monochorionic diamniotic twin pregnancies with and without twin-twin transfusion syndrome].
abstract: OBJECTIVE
  to evaluate the evolution of monochorionic-diamniotic twin pregnancies with and without the twin-twin transfusion syndrome (TTTS), followed up in an expectant way.
  
  
  METHODS
  retrospective study in which the pregnancies with and without TTTS and with mild (Quintero's stage I) and severe (Quintero's stages II, III, IV and V) disease manifestations were compared according to extreme preterm delivery, neurological impairment and the twins' nursery discharge. The extreme preterm twins who had had TTTS, or not, were compared whether they had or not neurological impairment. The chi2 or Fisher's exact test were used.
  
  
  RESULTS
  among 149 monochorionic-diamniotic twin pregnancies, 15 presented TTTS, 11 (11/15 - 73.3%) in the severe form and 4 (4/15 - 26.7%) at stage I. The extreme preterm delivery was more frequent (p<0.001) in the cases with the disease (11/15 - 73.3%) than in the cases without it (25/134 - 18.7%), and more common (p=0.033) in severe (10/11 - 91.1%) than in mild cases (1/4 - 25.0%). Neurological impairment in at least one twin was more frequent in cases with (5/8 - 62.5%) than in cases without (9/134 - 6.7%) the disease (p<0.001). Nursery discharge of at least one twin was more common (p<0.001) in cases without (132/134 - 98.5%) than in cases with the disease (8/15 - 53.0%). Neurological impairment in at least one of the twins was more frequent (p=0.04) in the severe (5/5 - 100%) than in the mild (1/4 - 25%) form of the disease. Nursery discharge of both twins was more common (p=0.004) at stage I (4/4 - 100%), than in the severe form of the disease (1/11 - 9.0%). Among the 47 extreme preterm twins, the neurological impairment was more frequent (p=0.001) among the ones who had (6/6 - 100%), than among those who did not have TTTS (11/41 - 26.8%).
  
  
  CONCLUSIONS
  cases with twin-twin transfusion syndrome, followed up in an expectant way have bad perinatal prognosis, with high neonatal mortality and high rates of neurological arrest among the survivors.
authors.affiliation: Departamento de Obstetrícia e Ginecologia, Centro de Atenção Integral à Saúde da Mulher, CEP 13083-970 - Campinas, SP, Brasil. cfaperalta@hotmail.com
authors.forename: Cleisson Fábio Andrioli
authors.initials: CF
authors.lastname: Peralta
authors.forename: Luciana Emy
authors.initials: LE
authors.lastname: Ishikawa
authors.forename: Renato
authors.initials: R
authors.lastname: Passini Júnior
authors.forename: João Renato
authors.initials: JR
authors.lastname: Bennini Júnior
authors.forename: Marcelo Luiz
authors.initials: ML
authors.lastname: Nomura
authors.forename: Izilda Rodrigues Machado
authors.initials: IR
authors.lastname: Rosa
authors.forename: Ricardo
authors.initials: R
authors.lastname: Barini
mesh_terms: D000650:Amnion; D002823:Chorion; D005260:Female; D005330:Fetofetal Transfusion / Q000150:complications; D006801:Humans; D009422:Nervous System Diseases / Q000209:etiology; D011247:Pregnancy; D011272:Pregnancy, Multiple; D012189:Retrospective Studies