[Behavior study of ketamine-induced symptoms similar to schizophrenia in mice].
OBJECTIVE
To observe the symptoms similar to schizophrenia in mice after ketamine single or continuous injection and to evaluate the feasibility of schizophrenia model injected with different dose of ketamine.


METHODS
A total of 40 male mice were randomly divided into 4 groups, which were injected intraperitoneally with physiological saline (control group), 25 mg/kg ketamine (low dose group), 50 mg/kg ketamine (middle dose group), and 100 mg/kg ketamine (high dose group) qd for 7 days continuously. The behavior changes of mice were observed.


RESULTS
Hyperactivity, stereotyped behavior and ataxia (P < 0.01) were observed in high dose group after single injection. After continuous injection of ketamine for 7 days, the middle dose group showed hyperactivity, stereotyped behavior and ataxia (P < 0.05), stereotyped behavior and ataxia were more significant in high dose group (P < 0.01).


CONCLUSIONS
Ketamine can induce the symptoms similar to schizophrenia in mice after single or continuous injection. The symptoms induced by high dose ketamine will be more prominent and stable after continuous injection.
Liu
Wei-Li
WL
Department of Forensic Medicine, Medical College of Soochow University, Suzhou 215123, China. liuweilisuda@sohu.com
Bian
Shi-Zhong
SZ
Gu
Zhen-Lun
ZL
Jiang
Xiao-Gang
XG
Guo
Ci-Yi
CY
Zhao
Yan-Bo
YB
D000818:Animals; D001259:Ataxia / Q000139:chemically induced / Q000473:pathology; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005555:Forensic Psychiatry; D007274:Injections, Intraperitoneal; D007649:Ketamine / Q000008:administration & dosage*; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D011897:Random Allocation; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors*; D012559:Schizophrenia / Q000139:chemically induced / Q000473:pathology*; D013239:Stereotyped Behavior / Q000187:drug effects*
D016194:Receptors, N-Methyl-D-Aspartate; D007649:Ketamine