title: Polycystic ovary syndrome is associated with an increased prevalence of irritable bowel syndrome.
abstract: BACKGROUND
  Polycystic ovary syndrome (PCOS) affects 5-10% of reproductive-aged women. Irritable bowel syndrome (IBS) is a chronic intestinal disorder that affects up to 20% of adults, more often women. We evaluate if there is a relationship between these common conditions.
  
  
  METHODS
  Polycystic ovary syndrome and control subjects were prospectively recruited. A questionnaire was given to determine their gastrointestinal symptoms. Body mass index (BMI) and percent body fat were also calculated.
  
  
  RESULTS
  About 65 female subjects completed the study. Among the 36 PCOS patients, 15 subjects (42%) had IBS, compared to 3 subjects (10%) among controls (p < 0.01). Control subjects were leaner (BMI: 27.5 +/- 1.1 vs. 31.4 +/- 1.2 kg/m(2), p < 0.05) than PCOS patients. Among women with PCOS, those with IBS had a higher BMI (32.9 +/- 2.0 kg/m(2)) compared to those with PCOS but no IBS (30.3 +/- 1.6 kg/m(2)) and controls (27.5 +/- 1.1 kg/m(2); p < 0.05). This difference was true even after correcting for BMI and age (p < 0.01).
  
  
  CONCLUSIONS
  Women with PCOS have a higher prevalence of IBS compared to healthy controls. When IBS is present with PCOS, a higher BMI and percent body fat is seen compared to PCOS alone.
authors.affiliation: Department of Obstetrics/Gynecology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
authors.forename: Ruchi
authors.initials: R
authors.lastname: Mathur
authors.forename: Ara
authors.initials: A
authors.lastname: Ko
authors.forename: Laura J
authors.initials: LJ
authors.lastname: Hwang
authors.forename: Kimberly
authors.initials: K
authors.lastname: Low
authors.forename: Ricardo
authors.initials: R
authors.lastname: Azziz
authors.forename: Mark
authors.initials: M
authors.lastname: Pimentel
mesh_terms: D000273:Adipose Tissue; D000328:Adult; D001823:Body Composition; D015992:Body Mass Index; D015897:Comorbidity; D003430:Cross-Sectional Studies; D017097:Electric Impedance; D005260:Female; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000175:diagnosis / Q000453:epidemiology*; D011085:Polycystic Ovary Syndrome / Q000175:diagnosis / Q000453:epidemiology*; D011446:Prospective Studies
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