Synthesis and olfactory evaluation of bulky moiety-modified analogues to the sandalwood odorant Polysantol.
Five new bulky moiety-modified analogues of the sandalwood odorant Polysantol have been synthesized by aldol condensation of appropriate aldehydes with butanone, deconjugative alpha-methylation of the resulting alpha,beta-unsaturated ketones, and reduction of the corresponding beta,gamma-unsaturated ketones. The final compounds were evaluated organoleptically and one of them seemed to be of special interest for its natural sandalwood scent.
Chapado
Laura
L
Departamento de Química Inorgánica y Orgánica, Facultad de Ciencias Experimentales, Universidad de Jaén, 23071 Jaén, Spain.
Linares-Palomino
Pablo J
PJ
Badía
Concepción
C
Salido
Sofía
S
Nogueras
Manuel
M
Sánchez
Adolfo
A
Altarejos
Joaquín
J
D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009812:Odorants / Q000032:analysis*; D009930:Organic Chemicals / Q000138:chemical synthesis* / Q000737:chemistry*; D000081223:Polycyclic Sesquiterpenes; D032123:Santalum / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry; D013329:Structure-Activity Relationship
D009930:Organic Chemicals; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; C043206:santalol
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