title: Improved metabolic control after 12-week dietary intervention with low glycaemic isomalt in patients with type 2 diabetes mellitus.
abstract: The polyol isomalt (Palatinit) is a very low glycaemic sugar replacer. The effect of food supplemented with isomalt instead of higher glycaemic ingredients like sucrose and/or starch hydrolysates on metabolic control in patients with type 2 diabetes was examined in this open study. Thirty-three patients with type 2 diabetes received a diet with foods containing 30 g/d isomalt instead of higher-glycaemic carbohydrates for 12 weeks. Metformin and/or thiazolidindiones were the only concomitant oral antidiabetics allowed during the study. Otherwise, the participants maintained their usual diet during the test phase, but were instructed to refrain from additional sweetened foods. Before start, after 6 weeks and 12 weeks (completion of the study), blood samples were taken and analysed for clinical routine parameters, metabolic, and risk markers. Thirty-one patients completed the study. The test diet was well accepted and tolerated. After 12 weeks, significant reductions were observed for: glycosylated haemoglobin, fructosamine, fasting blood glucose, insulin, proinsulin, C-peptide, insulin resistance (HOMA-IR), and oxidised LDL (an atherosclerosis risk factor). In addition, significant lower nonesterified fatty acid concentrations were found in female participants. Routine blood measurements and blood lipids remained unchanged. The substitution of glycaemic ingredients by isomalt and the consequent on reduction of the glycaemic load within otherwise unchanged diet was accompanied by significant improvement in the metabolic control of diabetes. The present study is in agreement with findings of previous reported studies in human subjects demonstrating beneficial effects of low glycaemic diets on glucose metabolism in patients with diabetes mellitus type 2.
authors.affiliation: University of Würzburg, Department of Medicine II, Division of Gastroenterology, 97080 Würzburg, Germany. holub_i@medizin.uniwuerzburg.de
authors.forename: I
authors.initials: I
authors.lastname: Holub
authors.forename: A
authors.initials: A
authors.lastname: Gostner
authors.forename: S
authors.initials: S
authors.lastname: Hessdörfer
authors.forename: S
authors.initials: S
authors.lastname: Theis
authors.forename: G
authors.initials: G
authors.lastname: Bender
authors.forename: B
authors.initials: B
authors.lastname: Willinger
authors.forename: J
authors.initials: J
authors.lastname: Schauber
authors.forename: R
authors.initials: R
authors.lastname: Melcher
authors.forename: B
authors.initials: B
authors.lastname: Allolio
authors.forename: W
authors.initials: W
authors.lastname: Scheppach
mesh_terms: D054392:Adipokines / Q000097:blood; D001835:Body Weight; D050260:Carbohydrate Metabolism; D002326:Cariogenic Agents / Q000627:therapeutic use*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000178:diet therapy* / Q000378:metabolism* / Q000652:urine; D004032:Diet; D004187:Disaccharides / Q000627:therapeutic use*; D005243:Feces / Q000737:chemistry; D005260:Female; D038321:Glycemic Index / Q000502:physiology*; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D012307:Risk Factors; D013402:Sugar Alcohols / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D054392:Adipokines; D002326:Cariogenic Agents; D004187:Disaccharides; D008055:Lipids; D013402:Sugar Alcohols; C016640:Palatinit