title: Resonance Raman spectroscopy as an effective tool for the determination of antioxidative stability of cosmetic formulations.
abstract: Carotenoids beta-carotene, lutein, lycopene and others are well-known powerful antioxidants acting as an effective neutralizer of free radicals produced in the human organism as a result of the influence of stress factors, such as UV irradiation. The protective effect of antioxidants is used in cosmetic products to increase the skin protection against the destructive action of free radicals and for the stabilization of formulations against oxidation. In the skin, the different antioxidant substances form protection chains to avoid their destruction by the interaction with the free radicals. Similar effects have to be expected also in topically applied formulations. In the present study the influence of different mixtures of antioxidants (beta-carotene, vitamins C and E) on the stability of antioxidants in formulations used for skin treatment was investigated. The measurements were carried out by using non-invasive resonance Raman spectroscopy for the detection of the carotenoid concentration in the cosmetic formulations.
authors.affiliation: Center of Experimental and Applied Cutaneous Physiology, Department of Dermatology and Allergology, Charité-Universitätsmedizin Berlin, Germany. max_darvin@mail.ru
authors.forename: Maxim E
authors.initials: ME
authors.lastname: Darvin
authors.forename: Wolfram
authors.initials: W
authors.lastname: Sterry
authors.forename: Jürgen
authors.initials: J
authors.lastname: Lademann
mesh_terms: D000975:Antioxidants / Q000737:chemistry* / Q000528:radiation effects; D001205:Ascorbic Acid / Q000737:chemistry / Q000528:radiation effects; D002338:Carotenoids / Q000737:chemistry / Q000528:radiation effects; D003358:Cosmetics / Q000737:chemistry* / Q000528:radiation effects; D005609:Free Radicals / Q000737:chemistry; D006801:Humans; D007700:Kinetics; D013059:Spectrum Analysis, Raman / Q000295:instrumentation / Q000379:methods*; D014466:Ultraviolet Rays; D014810:Vitamin E / Q000737:chemistry / Q000528:radiation effects; D019207:beta Carotene / Q000737:chemistry / Q000528:radiation effects
chemical_list: D000975:Antioxidants; D003358:Cosmetics; D005609:Free Radicals; D019207:beta Carotene; D014810:Vitamin E; D002338:Carotenoids; D001205:Ascorbic Acid