Endocytosis of lipid-anchored proteins: excluding GEECs from the crowd.
Endocytosis of glycosylphosphatidylinositol (GPI)-linked proteins via a specific pathway into GPI-enriched early endosomal compartments (GEECs) has been proposed. How sorting into this pathway may take place is unclear. In this issue, Bhagatji et al. (2009. J. Cell Biol. doi:10.1083/jcb.200903102) provide an original mechanism for the sorting of lipid-anchored proteins that involves exclusion of bulky extracellular domains from clathrin-coated pits.
Nichols
Ben
B
Medical Research Council Laboratory of Molecular Biology, Cambridge CB20QH, England, UK. ben@mrc-lmb.cam.ac.uk
D002462:Cell Membrane / Q000737:chemistry / Q000378:metabolism; D002966:Clathrin / Q000378:metabolism; D003034:Coated Pits, Cell-Membrane / Q000378:metabolism; D004705:Endocytosis / Q000502:physiology*; D011992:Endosomes / Q000737:chemistry / Q000378:metabolism; D017261:Glycosylphosphatidylinositols / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism*; D015394:Molecular Structure
D002966:Clathrin; D017261:Glycosylphosphatidylinositols; D008565:Membrane Proteins
Nat Cell Biol. 2006 Jan;8(1):46-54
16341206
J Biol Chem. 1987 Nov 25;262(33):16127-34
3680245
Curr Biol. 2007 Jul 3;17(13):1151-6
17600709
J Cell Biol. 2009 Aug 24;186(4):615-28
19687251
Mol Biol Cell. 2004 Aug;15(8):3542-52
15146059
Cell. 2003 Nov 14;115(4):377-88
14622593
Cell. 2004 Feb 20;116(4):577-89
14980224
Dev Cell. 2002 Apr;2(4):411-23
11970892
Mol Biol Cell. 2001 Oct;12(10):3031-45
11598189
Nat Rev Mol Cell Biol. 2004 Feb;5(2):110-20
15040444
FEBS Lett. 2006 Oct 9;580(23):5559-64
16996501
Curr Biol. 2008 Nov 25;18(22):1802-8
19036340
Cell. 1992 Feb 21;68(4):673-82
1739974
Nature. 1997 Jun 5;387(6633):569-72
9177342
Nat Rev Mol Cell Biol. 2007 Aug;8(8):603-12
17609668
J Biol Chem. 2005 Jun 17;280(24):22839-46
15817446