title: Gamma probe (99m)Tc-pertechnetate assisted completion thyroidectomy vs conventional thyroidectomy in differentiated thyroid carcinoma.
abstract: Patients undergoing partial thyroidectomy for benign diseases may need re-operation if differentiated thyroid carcinoma (DTC) is detected on histopathology. The aim of this study was to determine if using gamma probe during the above surgery in a procedure called: gamma probe completion thyroidectomy (GPCT) could support the diagnosis of DTC tissue and offer an advantage in the surgical treatment of DTC patients. We have studied 100 patients who after bilateral subtotal thyroidectomy for benign disease in several hospitals, were found to have DTC histopathologically and referred to our clinic for subsequent re-operation. Of these, 50 underwent conventional completion thyroidectomy (Group I) and 50 underwent GPCT (Group II). We compared retrospectively Group I and Group II in terms of volume of residual thyroid tissue, thyroid stimulating hormone (TSH) values, complication rates and incidence of tumor found in the residual thyroid. Our results showed that one month postoperatively, TSH was significantly higher in Group II (P<0.001). Volumes of residual thyroid were also significantly less in Group II (P<0.000). Complications and the incidence of tumor cells found in the residual thyroid tissue between the groups were not statistically different (P>0.05). In conclusion, GPCT in patients with DTC significantly increased the success of this operation in localizing and removing residual thyroid tissue.
authors.affiliation: Department of Surgery, Okmeydani Training and Research Hospital, Sisli- Istanbul, Turkey.
authors.forename: Omer
authors.initials: O
authors.lastname: Bender
authors.forename: Savas
authors.initials: S
authors.lastname: Karyagar
authors.forename: Fatih
authors.initials: F
authors.lastname: Levent Balci
authors.forename: Enis
authors.initials: E
authors.lastname: Yuney
authors.forename: Sedat
authors.initials: S
authors.lastname: Kamali
authors.forename: Tevfik
authors.initials: T
authors.lastname: Ozpacaci
authors.forename: Mehmet
authors.initials: M
authors.lastname: Mulazimoglu
authors.forename: Ercan
authors.initials: E
authors.lastname: Uyanik
authors.forename: Sevda S
authors.initials: SS
authors.lastname: Karyagar
authors.forename: Yavuz Selim
authors.initials: YS
authors.lastname: Sari
mesh_terms: D000293:Adolescent; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D013670:Sodium Pertechnetate Tc 99m; D025321:Surgery, Computer-Assisted / Q000379:methods*; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery*; D013965:Thyroidectomy / Q000379:methods*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D019275:Radiopharmaceuticals; D013670:Sodium Pertechnetate Tc 99m