Multicenter clinical study on the treatment of children's tic disorder with Qufeng Zhidong Recipe.
OBJECTIVE
To assess the effect and adverse reaction of Qufeng Zhidong Recipe (QZR) in treating children's tic disorder (TD).


METHODS
With multicenter randomized parallel open-controlled method adopted, the patients enrolled were assigned to two groups, 41 cases in the Chinese medicine (CM) group and 40 in the Western medicine (WM) group. They were treated by QZR and haloperidol plus trihexyphenidyl respectively for 12 weeks as one course. In total, two courses of treatment were given. The curative effect and adverse reactions were evaluated by scoring with Yale Global Tic Severity Scale (YGTSS), Traditional Chinese Medicine Syndrome Scale (TCMSS), and Treatment Emergent Symptom Scale (TESS), as well as results of laboratory examinations.


RESULTS
After one course of treatment, the markedly effective rate in the CM and the WM group was 14.6% and 17.5%, respectively, and the total effective rate 43.9% and 47.5%, respectively, which showed insignificant difference between groups (P>0.05). However, after two courses of treatment, markedly effective rate in them was 73.2% and 7.5%, and the total effective rate was 100.0% and 57.5%, both showing significant differences between groups (P<0.05). Besides, the adverse reactions occurred in the CM group was less than that in the WM group obviously.


CONCLUSIONS
QZR has definite curative effect with no apparent adverse reaction in treating TD, and it can obviously improve the symptoms and signs and upgrade the quality of life and learning capacities in such patients.
Wu
Min
M
Xinhua Hospital Affiliated to Medical School of Shanghai Jiaotong University, Shanghai, 200092, China. xinhuayiyuan123@126.com
Xiao
Guang-hua
GH
Yao
Min
M
Zhang
Jian-ming
JM
Zhang
Xin
X
Zhou
Ya-bing
YB
Zhang
Jing-yan
JY
Wang
Shu-xia
SX
Ma
Bo
B
Chen
Yan-ping
YP
D000978:Antiparkinson Agents / Q000008:administration & dosage / Q000009:adverse effects; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D055927:Cookbooks as Topic; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006220:Haloperidol / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D008297:Male; D013981:Tic Disorders / Q000188:drug therapy*; D016896:Treatment Outcome; D014282:Trihexyphenidyl / Q000008:administration & dosage / Q000009:adverse effects; D019366:Western World
D000978:Antiparkinson Agents; D014150:Antipsychotic Agents; D004365:Drugs, Chinese Herbal; C545315:qufeng zhidong; D014282:Trihexyphenidyl; D006220:Haloperidol
Arch Gen Psychiatry. 2002 Jul;59(7):649-56
12090818
J Am Acad Child Adolesc Psychiatry. 1989 Jul;28(4):566-73
2768151