[Biofilm and bacterial microrganisms in genito-urinary infections].
Biofilms represent a cohesive matrix of microrganisms and other cellular constituents that might be present in any natural environment. Microrganisms able to produce biofilms undergo a number of distinctive and typical phenomenon, such as adhesiveness on infected cellular surfaces that consequently becomes irreversible, so deeply changing the microrganisms physiological status. In addition, biofilms play a central role in consenting microrganisms to survive and subsequently to spread in the host, since exocellular matrix protects pathogen bacteria from antibodies and immunocompetent cells devoted to their destruction, and from antimicrobial agents. So, use of antimicrobials able to penetrate cellular membrane and to act into the cell has to be considered as essential in the treatment of infections that may possibly involve biofilm-producer microrganisms, considering their aggressive and virulent behaviour and their intrinsic bacterial resistance.
Mazzoli
Sandra
S
Centro per le Malattie a Trasmissione Sessuale, ASL 10, Firenze, Italy.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics / Q000627:therapeutic use; D018441:Biofilms / Q000187:drug effects; D004352:Drug Resistance, Microbial; D005260:Female; D052776:Female Urogenital Diseases / Q000188:drug therapy / Q000382:microbiology*; D006090:Gram-Negative Bacteria / Q000187:drug effects / Q000472:pathogenicity / Q000502:physiology; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy / Q000382:microbiology*; D006094:Gram-Positive Bacteria / Q000187:drug effects / Q000472:pathogenicity / Q000502:physiology; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy / Q000382:microbiology*; D006801:Humans; D008297:Male; D052801:Male Urogenital Diseases / Q000188:drug therapy / Q000382:microbiology*; D051379:Mice; D014552:Urinary Tract Infections / Q000188:drug therapy / Q000382:microbiology; D014774:Virulence
D000900:Anti-Bacterial Agents