Emerging hematological targets and therapy for cardiovascular disease: From bench to bedside.
Atherosclerotic cardiovascular disease is the leading cause of death and a major part of its pathophysiology remains obscure. Some hematological targets have been related to the development and clinical outcome of this disease, especially soluble cytokines, leukocytes, red blood cells, hemostatic factors and platelets, and bone-marrow vascular progenitors. These emerging factors may be modulated by current antiatherosclerotic pharmacotherapy, target-designed novel drugs or progenitor cell therapy. The aim of current review article is to comprehensively review the role of these antiatherosclerotic targets and therapy.
Villegas
Ana
A
Service of Hematology and Hemotherapy, Hospital, Clinico Universitario, San Carlos, Madrid, Spain.
Gonzalez
Fernando A
FA
Llorente
Leopoldo
L
Redondo
Santiago
S
Cardiovasc Res. 2003 Mar;57(3):816-23
12618243
J Am Coll Cardiol. 2002 Oct 2;40(7):1333-8
12383583
Free Radic Biol Med. 2006 May 15;40(10):1796-803
16678017
Circulation. 2005 Nov 22;112(21):3337-47
16301360
Am J Physiol Heart Circ Physiol. 2004 Dec;287(6):H2651-8
15284068
J Card Fail. 2007 Nov;13(9):701-8
17996817
J Am Coll Cardiol. 2007 May 1;49(17):1772-80
17466227
FASEB J. 2005 Aug;19(10):1323-5
15946993
Circulation. 2006 Apr 25;113(16):1983-92
16531621
Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3566-71
9520406
N Engl J Med. 2003 Feb 13;348(7):593-600
12584367
N Engl J Med. 2006 Apr 20;354(16):1706-17
16531616
Circulation. 2002 Feb 26;105(8):993-8
11864931
Science. 1997 Feb 14;275(5302):964-7
9020076
Lancet. 2000 May 13;355(9216):1688-91
10905245
Hypertens Res. 2007 Jun;30(6):541-8
17664858
Circ Res. 2008 Feb 1;102(2):209-17
17991882
J Cell Mol Med. 2004 Oct-Dec;8(4):498-508
15601578
Circulation. 2004 Sep 7;110(10):1209-12
15249502
Eur Heart J. 2007 Feb;28(4):499-509
17242014
Nutr Rev. 1989 Jan;47(1):23-5
2649802
Vasc Med. 2007 Nov;12(4):275-83
18048463
Arch Intern Med. 2005 Nov 28;165(21):2473-8
16314543
Hypertension. 2000 Oct;36(4):517-22
11040229
Blood. 2005 Sep 1;106(5):1525-31
15905185
Arterioscler Thromb Vasc Biol. 2004 Aug;24(8):1529-34
15205218
Arterioscler Thromb Vasc Biol. 2000 May;20(5):1362-73
10807755
Circulation. 2006 Mar 14;113(10):1287-94
16520413
N Engl J Med. 2007 Nov 22;357(21):2123-32
18032762
Cardiovasc Drugs Ther. 2006 Apr;20(2):135-41
16761193
Circ Res. 2001 Jul 6;89(1):E1-7
11440984
Arterioscler Thromb Vasc Biol. 2003 Sep 1;23(9):1690-6
12855480
Int J Mol Med. 2006 Feb;17(2):203-8
16391816
Oncologist. 2007 Jun;12(6):713-8
17602060
Scand J Immunol. 2006 Sep;64(3):336-44
16918703
Mol Cancer Res. 2002 Dec;1(2):89-95
12496355
Nat Rev Immunol. 2006 Jul;6(7):508-19
16778830
Atherosclerosis. 2001 Oct;158(2):277-87
11583705
Cardiovasc Res. 2007 Jul 1;75(1):21-8
17412313
Stroke. 2004 Jul;35(7):1619-24
15155967
Diabetes. 2005 Aug;54(8):2415-23
16046309
Arterioscler Thromb Vasc Biol. 2005 Dec;25(12):2636-41
16195475
J Cardiovasc Pharmacol. 2007 Jul;50(1):61-7
17666917
J Cell Mol Med. 2006 Jul-Sep;10(3):727-33
16989732
Circ Res. 2005 Apr 1;96(6):612-6
15802619
Ann Intern Med. 2006 Jul 4;145(1):35-42
16818927
Arterioscler Thromb Vasc Biol. 2001 Jun;21(6):997-1003
11397710
J Am Coll Cardiol. 2007 Jun 19;49(24):2341-9
17572250
PLoS Med. 2005 May;2(5):e133
15916467
Circulation. 2004 Mar 23;109(11):1392-400
14993120
Thromb Haemost. 2007 Jun;97(6):979-87
17549301
Stroke. 2005 Apr;36(4):715-9
15746459
Circulation. 2002 Apr 9;105(14):1650-5
11940542
Circ Res. 2007 Apr 27;100(8):1234-41
17379833
Cardiovasc Res. 2005 Oct 1;68(1):47-55
16023093
J Am Coll Cardiol. 2006 Oct 17;48(8):1579-87
17045891
JAMA. 2007 Dec 12;298(22):2634-43
18073359
Arterioscler Thromb Vasc Biol. 2006 Sep;26(9):2140-6
16857948
J Am Coll Cardiol. 2006 Oct 17;48(8):1588-90
17045892
Circulation. 2003 Jan 28;107(3):391-7
12551861
Nat Med. 1995 Jan;1(1):74-9
7584958
N Engl J Med. 2003 Dec 11;349(24):2316-25
14668457
J Am Coll Cardiol. 2002 Jan 16;39(2):241-6
11788214
Circulation. 2005 Jun 7;111(22):2981-7
15927972
J Mol Cell Cardiol. 2006 Jul;41(1):34-43
16678199
JAMA. 2006 Mar 1;295(9):1003-10
16507801
Eur J Pharmacol. 2007 May 7;562(1-2):111-8
17320859
Nat Med. 2002 Apr;8(4):403-9
11927948
Atherosclerosis. 2007 Jun;192(2):413-20
16837000
N Engl J Med. 1999 Jan 14;340(2):115-26
9887164
J Am Coll Cardiol. 2001 Nov 1;38(5):1307-12
11691500
Arch Intern Med. 2007 May 28;167(10):989-97
17533201
Exp Hematol. 2007 Dec;35(12):1884-90
17923244
Arterioscler Thromb Vasc Biol. 2006 Oct;26(10):2238-43
16902165
Hypertension. 2005 Apr;45(4):526-9
15767470
Cardiovasc Res. 2008 Apr 1;78(1):185-96
18065445
Circ Res. 2006 Jun 9;98(11):1405-13
16645141
Rev Esp Cardiol. 2005 Mar;58(3):253-61
15766447
Am Heart J. 2006 Dec;152(6):1051.e1-8
17161050
Atherosclerosis. 2005 Dec;183(2):301-7
16285993
Arterioscler Thromb Vasc Biol. 2007 Jan;27(1):134-40
17068284
Circulation. 2001 Jun 19;103(24):2885-90
11413075
Med Hypotheses. 2008;70(3):512-4
17764856
BMJ. 1994 Jan 8;308(6921):81-106
8298418
Circulation. 2004 Apr 27;109(16):2001-8
15078795
Diabetes Care. 2006 Jun;29(6):1363-9
16732022
Atherosclerosis. 2006 Dec;189(2):288-96
16455087
Atherosclerosis. 2005 Aug;181(2):305-10
16039284
Circ Res. 2007 Mar 2;100(4):590-7
17272812
Exp Cell Res. 2006 Sep 10;312(15):2933-41
16893539
Diabetes. 2007 Oct;56(10):2609-15
17623816
Circ Res. 2006 Sep 1;99(5):553-60
16873716
J Clin Invest. 2001 Aug;108(3):391-7
11489932
Blood. 2008 Jan 15;111(2):905-14
17911385
Eur Heart J. 2005 Jun;26(12):1196-204
15734770
J Hypertens. 2005 Jan;23(1):97-104
15643130
Stroke. 2007 Nov;38(11):2900-5
17901385
FASEB J. 2005 Jun;19(8):992-4
15814609
Blood. 2005 Dec 1;106(12):4002-8
16105977
Haematologica. 2006 Oct;91(10):1329-35
17018381
BMJ. 2002 Jan 12;324(7329):71-86
11786451
Eur Heart J. 2006 Dec;27(23):2775-83
17098754
Nat Med. 2007 Aug;13(8):952-61
17660828
Cardiology. 1998 Jul;90(1):52-7
9693172
Am Heart J. 2006 Jul;152(1):190-5
16824855
J Am Coll Cardiol. 2005 Sep 20;46(6):937-54
16168274
J Am Coll Cardiol. 2004 Nov 16;44(10):1945-56
15542275
Lancet. 2007 Oct 6;370(9594):1209-18
17920916
Nat Med. 2003 Jun;9(6):736-43
12740573
Circulation. 2003 Dec 16;108(24):2993-9
14638538
J Clin Invest. 2004 May;113(9):1249-51
15124012
Ann Pharmacother. 2003 Apr;37(4):478-84
12659599
Acta Pharmacol Sin. 2006 Apr;27(4):430-6
16539843
Blood. 2004 Apr 15;103(8):2908-13
15070662
Circulation. 1999 Aug 24;100(8):793-8
10458713
Nat Clin Pract Cardiovasc Med. 2006 Mar;3 Suppl 1:S73-7
16501636
Circulation. 2007 Oct 30;116(18):2053-61
17938286
J Cardiopulm Rehabil Prev. 2007 Mar-Apr;27(2):65-73
17558240
J Am Coll Cardiol. 2007 Oct 30;50(18):1761-7
17964040
Eur Heart J. 2006 Jun;27(11):1338-40
16543252
Inflammation. 1998 Aug;22(4):367-79
9675608
Circulation. 2004 Dec 21;110(25):e554-9
15611381
Stem Cells. 2006 Oct;24(10):2279-83
16794269
Transfusion. 2005 Mar;45(3):295-300
15752146
N Engl J Med. 2006 Sep 21;355(12):1274-7
16990391
Blood. 2002 Jun 15;99(12):4475-85
12036878
PLoS One. 2007 Oct 10;2(10):e975
17925881
Circulation. 2004 Apr 27;109(16):2016-22
15051635
Blood. 2005 Apr 1;105(7):2733-40
15591120
Blood. 2006 Mar 15;107(6):2531-5
16317105
BMC Cardiovasc Disord. 2005 May 20;5(1):10
15943888
Arterioscler Thromb Vasc Biol. 2007 Mar;27(3):690-6
17185615
Cytokine Growth Factor Rev. 2007 Jun-Aug;18(3-4):279-86
17485238
Am J Cardiol. 2007 Jun 1;99(11):1500-3
17531569
Proc Natl Acad Sci U S A. 2003 Sep 30;100(20):11612-7
14500913
Int J Cardiol. 2004 Oct;97(1):155-6
15336829
Atherosclerosis. 2006 Aug;187(2):351-62
16253262
Circulation. 2000 Mar 14;101(10):1206-18
10715270
Thromb Haemost. 2007 Jul;98(1):201-9
17598014
J Am Coll Cardiol. 2003 Feb 19;41(4 Suppl S):7S-14S
12644335
Curr Pharm Des. 2006;12(21):2689-99
16842167
Circulation. 2000 Aug 8;102(6):624-9
10931801
Circulation. 2004 Jan 20;109(2):220-6
14691039
J Am Coll Cardiol. 2006 May 2;47(9):1786-95
16682302
Handb Exp Pharmacol. 2006;(174):283-98
16370332
Am J Cardiol. 2007 Jun 1;99(11):1598-602
17531588
N Engl J Med. 2006 Sep 21;355(12):1199-209
16990383
Circulation. 2003 Mar 4;107(8):1164-9
12615796
Cell. 2007 Nov 2;131(3):463-75
17981115
J Immunol. 2007 Sep 1;179(5):3242-8
17709540
Stem Cells. 2006 Feb;24(2):333-6
16223854
Arterioscler Thromb Vasc Biol. 2004 Jun;24(6):E137; author reply E137-8
15178573
Blood. 2005 Apr 15;105(8):3286-94
15618473
Rev Esp Cardiol. 2005 Jun;58(6):631-9
15970118
Arterioscler Thromb Vasc Biol. 2003 Jul 1;23(7):1185-9
12714439
Arch Intern Med. 2004 Feb 23;164(4):433-9
14980995
Arterioscler Thromb Vasc Biol. 2005 Mar;25(3):633-8
15591214
Blood. 2005 Sep 1;106(5):1867-74
15890685
J Am Coll Cardiol. 2004 Oct 19;44(8):1690-9
15489105
Stem Cells. 2006 Feb;24(2):357-67
16141361