[Determination of Th1/Th2 cytokines and chemokines in patients with allergic diseases and its significance].
OBJECTIVE
To determine Th1/Th2 cytokines and chemokines in patients with allergic diseases and its clinic significance.


METHODS
Serum levels of IFN-gamma, IL-4, IL-5, IL-13, Eotaxin, RANTES and LTB4 were determined from peripheral blood of 64 allergic patients and 21 healthy controls with ELISA.


RESULTS
IL-4, IL-5, IL-13 and Eotaxin, LTB4 were increased significantly in serum of allergic patients compared with those of controls (P<0.05). There were no significant differences in serum levels of IFN-gamma and RANTES between patients and controls (P>0.05). Serum levels of IL-4, IL-5, IL-13 and LTB4 were correlated with each other (P<0.01). Eotaxin, RANTES and IFN-gamma levels were also significantly correlated with each other (P<0.05). LTB4 was correlated with Eotaxin as well (P<0.01).


CONCLUSIONS
A wide range of cytokines and chemokines is involved in allergic diseases,which may play their roles in a complex interactive manner.
HAN
Rui
R
Department of Dermatology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou 310016, China.
LIN
Ai-hua
AH
ZHU
Ke-jian
KJ
CHENG
Hao
H
Wu
Shan-dong
SD
D000293:Adolescent; D000328:Adult; D000368:Aged; D018925:Chemokines / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000097:blood / Q000276:immunology*; D007371:Interferon-gamma / Q000097:blood; D018793:Interleukin-13 / Q000097:blood; D015847:Interleukin-4 / Q000097:blood; D007975:Leukotriene B4 / Q000097:blood; D008297:Male; D008875:Middle Aged; D018417:Th1 Cells / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology*; D055815:Young Adult
D018925:Chemokines; D016207:Cytokines; D018793:Interleukin-13; D007975:Leukotriene B4; D015847:Interleukin-4; D007371:Interferon-gamma