title: [Correlation index amylase-creatinine clearance to endogenous creatinine clearance in severe preeclampsia].
abstract: BACKGROUND
  Tubular lesion may cause acute renal insufficiency in pregnant patients with severe preeclampsia.
  
  
  OBJECTIVE
  To describe the correlation between the amylase/creatinine clearance ratio and endogenous creatinine depuration in pregnant patients with severe preeclampsia.
  
  
  METHODS
  Transversal study (pilot study) twenty eight women with pregnancies of 20 to 40 weeks complicated by severe preeclampsia were studied. Subjects had serum and urine creatinine and amylase determinations to calculate the amylase/creatinine clearance ratio (%). According to the results, two groups were formed: group A (> 3%) and group B (< or = 3%). The correlation between amylase/creatinine clearance ratio and endogenous creatinine depuration was evaluated.
  
  
  METHODS
  measures of central tendency and dispersion, Student's t-test, Pearson correlation coefficient (r) and linear regression were used.
  
  
  RESULTS
  Group A included 23 cases (82%) and group B included 5 cases (18%). Amylase/creatinine clearance ratio (%) for group A was 5.22 +/- 1.6 and for group B was 2.41 +/- 0.41 (p = 0.001). The endogenous creatinine depuration (mL /min. /1.73 m2 SC) for group A was 105.6 +/- 9.71 and for group B was 132.10 +/- 7.95 (p = 0.54). The r between amylase/creatinine clearance ratio and endogenous creatinine depuration for group A was -0.43 and for group B was -0.25.
  
  
  CONCLUSIONS
  A moderately significant negative correlation exists between amylase/creatinine clearance ratio and endogenous creatinine depuration.
authors.affiliation: Unidad de Cuidados Intensivos de Adultos, Unidad Médica de Alta Especialidad, Hospital de Ginecología y Obstetricia número 3, Centro Médico Nacional La Raza, IMSS, DF México. juangustavovazquez@hotmail.com
authors.forename: Juan Gustavo
authors.initials: JG
authors.lastname: Vázquez Rodríguez
authors.forename: Polita del Rocío
authors.initials: Pdel R
authors.lastname: Cruz Cruz
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Márquez Hubert
mesh_terms: D000328:Adult; D000681:Amylases / Q000378:metabolism*; D003404:Creatinine / Q000378:metabolism*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D010865:Pilot Projects; D011225:Pre-Eclampsia / Q000378:metabolism*; D011247:Pregnancy; D012720:Severity of Illness Index
chemical_list: D003404:Creatinine; D000681:Amylases