Epidermodysplasia-verruciformis-like eruption associated with gamma-papillomavirus infection in a patient with adult T-cell leukemia.
Epidermodysplasia verruciformis (EV) is a genodermatosis characterized by widespread and persistent cutaneous lesions caused by beta-papillomaviruses. Rare cases of acquired EV-like eruption associated with beta-papillomavirus infection have been reported in immunosuppressed patients. We report a case of acquired EV-like eruption in an immunosuppressed patient with adult T-cell leukemia. The cutaneous lesions clinically resembled pityriasis versicolor and exhibited the typical histological features of EV, but in some areas of the same biopsy specimen characteristic homogeneous intracytoplasmic inclusion bodies were observed. Although beta-papillomavirus was not detected by highly sensitive polymerase chain reaction, a putative novel type of gamma-papillomavirus was identified. This is the first documentation of an association between EV-like eruption and gamma-papillomavirus infection.
Kawai
Kazuhiro
K
Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan. kazkawai@m2.kufm.kagoshima-u.ac.jp
Egawa
Nagayasu
N
Kiyono
Tohru
T
Kanekura
Takuro
T
D001706:Biopsy; D004279:DNA, Viral / Q000032:analysis*; D003937:Diagnosis, Differential; D004819:Epidermodysplasia Verruciformis / Q000150:complications* / Q000175:diagnosis / Q000821:virology; D052689:Gammapapillomavirus / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000150:complications* / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D030361:Papillomavirus Infections / Q000150:complications* / Q000175:diagnosis / Q000821:virology; D016133:Polymerase Chain Reaction; D012867:Skin / Q000473:pathology* / Q000821:virology
D004279:DNA, Viral