Expression of the decay-accelerating factor (CD55) in renal transplants--a possible prediction marker of allograft survival.
BACKGROUND
Decay-accelerating factor (CD55) accelerates the decay of C3 and C5 convertases, participating in classical and alternative complement activation pathways. Complement activation plays a major role in antibody-mediated rejection of allografts (AMR); C4d is used as a marker of AMR. Emerging evidence suggests an important role of CD55 in the pathogenesis of AMR. The aim of this study was to investigate the expression of CD55 in renal allografts and to correlate it with the expression of C4d, allograft survival, changes in serum creatinine (SC).


METHODS
More than 200 renal allograft biopsies, performed for allograft dysfunction, were assessed for peritubular capillary (PTC) C4d and CD55 expression.


RESULTS
We found significant correlation between changes in SC and PTC CD55 staining pattern in patients with no PTC C4d staining. In these patients, SC increased from baseline by 2.2+0.34, 1.7+0.36, and 0.93+0.24 mg/dL in negative, focal, and diffuse PTC CD55 staining subgroups, respectively. Survival of renal allografts was better in diffuse PTC CD55 staining subgroup than in negative PTC CD55 staining subgroup.


CONCLUSIONS
These data suggest that CD55 expression has a protective effect on PTC C4d negative renal allografts, and the pattern of PTC CD55 expression may be used as a potential marker of renal allograft survival in patients with no evidence of AMR.
Brodsky
Sergey V
SV
Department of Pathology, The Ohio State University, Columbus, OH 43210, USA.
Nadasdy
Gyongyi M
GM
Pelletier
Ronald
R
Satoskar
Anjali
A
Birmingham
Daniel J
DJ
Hadley
Gregg A
GA
Obeidat
Khaled
K
Nadasdy
Tibor
T
D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D018958:CD55 Antigens / Q000378:metabolism*; D002196:Capillaries / Q000276:immunology; D015935:Complement C4b / Q000378:metabolism; D003170:Complement Pathway, Alternative; D005260:Female; D006085:Graft Survival / Q000276:immunology*; D006801:Humans; D007150:Immunohistochemistry; D007518:Isoantibodies / Q000378:metabolism; D053208:Kaplan-Meier Estimate; D007668:Kidney / Q000098:blood supply / Q000276:immunology / Q000473:pathology; D016030:Kidney Transplantation / Q000276:immunology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000378:metabolism; D014184:Transplantation, Homologous
D015415:Biomarkers; D018958:CD55 Antigens; D007518:Isoantibodies; D010446:Peptide Fragments; D015935:Complement C4b; C032261:complement C4d