[Effects of (-)-epigallocatechin-3-gallate on interleukin-1beta expression in mouse wound healing].
(-)-Epigallocatechin-3-gallate (EGCG), a main constituent of green tea polyphenols, plays important roles in antioxidative, anti-senescence, anti-tumor, anti-inflammation and bacterail action. In this study, effects of EGCG on the expression of IL-1beta gene and the IL-1beta level at wound sites during cutaneous wound healing were investigated with histological stain, ELISA and RT-PCR technique. The results show that EGCG (50 mg/L) inhibited the expression of IL-1beta gene and reduced the IL-beta level at wound sites at 72 h after cutaneous wound, but not change the expression of IL-1beta gene and the IL-1beta level at early stage (< or =24 h).
Shen
Yu Jia
YJ
College of Life Sciences, Henan Normal University, Henan Xinxiang 453007.
Li
Wei Guo
WG
Zhang
Hui
H
Li
Bin
B
Yuan
Hong Xu
HX
Zhang
Jiang Jiang
JJ
D000818:Animals; D002392:Catechin / Q000031:analogs & derivatives* / Q000494:pharmacology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects*; D053583:Interleukin-1beta / Q000235:genetics* / Q000378:metabolism; D008297:Male; D051379:Mice; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects* / Q000235:genetics*
D053583:Interleukin-1beta; D002392:Catechin; C045651:epigallocatechin gallate