Biocatalytic production of acyclic bis[bibenzyls] from dihydroresveratrol by crude Momordica charantia peroxidase.
Biotransformation of dihydroresveratrol by crude Momordica charantia peroxidase provided six new acyclic bis[bibenzyls] 1-6. Their structures were established on the basis of NMR and MS analyses as C-C, C-O-C, and C-CH(2)-C dimers of dihydroresveratrol. Compounds 1-6 were tested for antiproliferative activity against human prostate cancer PC3 cell line in vitro, and 2 and 6 were found to be more potent than the parent compound.
Xie
Chun-Feng
CF
School of Pharmaceutical Sciences, Shandong University, Jinan, PR China.
Yuan
Hui-Qing
HQ
Qu
Jian-Bo
JB
Xing
Jie
J
Lü
Bei-Bei
BB
Wang
Xiao-Ning
XN
Ji
Mei
M
Lou
Hong-Xiang
HX
D000972:Antineoplastic Agents, Phytogenic / Q000096:biosynthesis / Q000627:therapeutic use; D001632:Bibenzyls / Q000378:metabolism* / Q000627:therapeutic use; D055162:Biocatalysis; D001711:Biotransformation; D045744:Cell Line, Tumor; D002851:Chromatography, High Pressure Liquid; D019281:Dimerization; D006801:Humans; D008297:Male; D029777:Momordica charantia / Q000201:enzymology*; D010544:Peroxidases / Q000378:metabolism*; D011471:Prostatic Neoplasms / Q000188:drug therapy; D021241:Spectrometry, Mass, Electrospray Ionization; D013267:Stilbenes / Q000378:metabolism*
D000972:Antineoplastic Agents, Phytogenic; D001632:Bibenzyls; D013267:Stilbenes; C544754:dihydroresveratrol; D010544:Peroxidases