title: African swine fever: how can global spread be prevented?
abstract: African swine fever (ASF) is a devastating haemorrhagic fever of pigs with mortality rates approaching 100 per cent. It causes major economic losses, threatens food security and limits pig production in affected countries. ASF is caused by a large DNA virus, African swine fever virus (ASFV). There is no vaccine against ASFV and this limits the options for disease control. ASF has been confined mainly to sub-Saharan Africa, where it is maintained in a sylvatic cycle and/or among domestic pigs. Wildlife hosts include wild suids and arthropod vectors. The relatively small numbers of incursions to other continents have proven to be very difficult to eradicate. Thus, ASF remained endemic in the Iberian peninsula until the mid-1990s following its introductions in 1957 and 1960 and the disease has remained endemic in Sardinia since its introduction in 1982. ASF has continued to spread within Africa to previously uninfected countries, including recently the Indian Ocean islands of Madagascar and Mauritius. Given the continued occurrence of ASF in sub-Saharan Africa and increasing global movements of people and products, it is not surprising that further transcontinental transmission has occurred. The introduction of ASF to Georgia in the Caucasus in 2007 and dissemination to neighbouring countries emphasizes the global threat posed by ASF and further increases the risks to other countries. We review the mechanisms by which ASFV is maintained within wildlife and domestic pig populations and how it can be transmitted. We then consider the risks for global spread of ASFV and discuss possibilities of how disease can be prevented.
authors.affiliation: The Royal Veterinary College, Hatfield, Hertfordshire AL9 7TA, UK.
authors.forename: Solenne
authors.initials: S
authors.lastname: Costard
authors.forename: Barbara
authors.initials: B
authors.lastname: Wieland
authors.forename: William
authors.initials: W
authors.lastname: de Glanville
authors.forename: Ferran
authors.initials: F
authors.lastname: Jori
authors.forename: Rebecca
authors.initials: R
authors.lastname: Rowlands
authors.forename: Wilna
authors.initials: W
authors.lastname: Vosloo
authors.forename: Francois
authors.initials: F
authors.lastname: Roger
authors.forename: Dirk U
authors.initials: DU
authors.lastname: Pfeiffer
authors.forename: Linda K
authors.initials: LK
authors.lastname: Dixon
mesh_terms: D017954:Africa South of the Sahara / Q000453:epidemiology; D000357:African Swine Fever / Q000276:immunology / Q000517:prevention & control* / Q000635:transmission; D000358:African Swine Fever Virus / Q000254:growth & development* / Q000276:immunology; D000818:Animals; D000829:Animals, Domestic; D000835:Animals, Wild; D026863:Ixodidae / Q000821:virology*; D013552:Swine; D013984:Tick Infestations / Q000662:veterinary* / Q000821:virology
references.citation: Prev Vet Med. 1997 Oct;32(3-4):235-41
references.pmid: 9443330
references.citation: Vet Microbiol. 2007 Mar 31;121(1-2):45-55
references.pmid: 17174485
references.citation: Transbound Emerg Dis. 2008;55(1):57-72
references.pmid: 18397509
references.citation: Rev Sci Tech. 1995 Sep;14(3):655-66
references.pmid: 8593399
references.citation: Onderstepoort J Vet Res. 1985 Sep;52(3):201-9
references.pmid: 3911134
references.citation: J Hyg (Lond). 1985 Oct;95(2):309-23
references.pmid: 4067292
references.citation: J Comp Pathol. 1989 Feb;100(2):145-54
references.pmid: 2715397
references.citation: Acta Trop. 1976;33(1):57-67
references.pmid: 13634
references.citation: Res Vet Sci. 1985 Nov;39(3):353-6
references.pmid: 4081341
references.citation: Rev Sci Tech. 1997 Apr;16(1):65-78
references.pmid: 9329109
references.citation: J Gen Virol. 2008 Feb;89(Pt 2):397-408
references.pmid: 18198370
references.citation: Trop Anim Health Prod. 1990 May;22(2):127-31
references.pmid: 2371751
references.citation: Virology. 1994 Jan;198(1):350-4
references.pmid: 8259670
references.citation: J Virol. 2000 Feb;74(3):1275-85
references.pmid: 10627538
references.citation: Prev Vet Med. 2005 May 10;68(2-4):115-22
references.pmid: 15820111
references.citation: Trop Anim Health Prod. 1984 May;16(2):123-5
references.pmid: 6485098
references.citation: J Hyg (Lond). 1986 Jun;96(3):535-44
references.pmid: 3734435
references.citation: Parasitol Res. 2007 Sep;101 Suppl 2:S159-62
references.pmid: 17823819
references.citation: Virus Genes. 2007 Dec;35(3):729-35
references.pmid: 17674176
references.citation: Rev Sci Tech. 2006 Apr;25(1):93-103
references.pmid: 16796039
references.citation: Onderstepoort J Vet Res. 2007 Jun;74(2):149-60
references.pmid: 17883201
references.citation: Virology. 1998 Apr 10;243(2):461-71
references.pmid: 9568043
references.citation: Virology. 1996 Apr 1;218(1):285-9
references.pmid: 8615037
references.citation: Vet Rec. 1994 Feb 19;134(8):183-7
references.pmid: 8171792
references.citation: Res Vet Sci. 1987 Jul;43(1):109-12
references.pmid: 2820006
references.citation: Rev Sci Tech. 2006 Apr;25(1):105-17
references.pmid: 16796040
references.citation: J Gen Virol. 2004 Aug;85(Pt 8):2177-2187
references.pmid: 15269356
references.citation: J Gen Virol. 2001 Mar;82(Pt 3):513-523
references.pmid: 11172092
references.citation: Arch Virol. 2003 Apr;148(4):693-706
references.pmid: 12664294
references.citation: Vet Microbiol. 2004 Nov 15;103(3-4):169-82
references.pmid: 15504588
references.citation: Prev Vet Med. 2001 Mar 29;48(4):261-71
references.pmid: 11259819
references.citation: Virus Genes. 2005 Dec;31(3):357-60
references.pmid: 16175341
references.citation: Vet Parasitol. 1987 Dec;26(1-2):145-55
references.pmid: 3326244
references.citation: Onderstepoort J Vet Res. 1983 Jun;50(2):145-8
references.pmid: 6634088
references.citation: Exp Appl Acarol. 2001;25(3):263-9
references.pmid: 11523921
references.citation: Arch Inst Pasteur Madagascar. 2001;67(1-2):31-3
references.pmid: 12471744
references.citation: Jpn J Vet Res. 1996 Aug;44(2):119-24
references.pmid: 8870391
references.citation: Lancet. 2008 Aug 23;372(9639):615-8
references.pmid: 18727178
references.citation: Epidemiol Infect. 1989 Jun;102(3):507-22
references.pmid: 2737257
references.citation: Curr Top Microbiol Immunol. 1985;116:151-70
references.pmid: 3893908
references.citation: J Gen Virol. 1990 Oct;71 ( Pt 10):2331-40
references.pmid: 2230738
references.citation: Epidemiol Infect. 1988 Aug;101(1):173-85
references.pmid: 3402546
references.citation: Emerg Infect Dis. 2008 Dec;14(12):1870-4
references.pmid: 19046509
references.citation: Onderstepoort J Vet Res. 1980 Mar;47(1):19-22
references.pmid: 7454231
references.citation: Rev Sci Tech. 2002 Dec;21(3):465-75
references.pmid: 12530354
references.citation: Vet Rec. 1998 Aug 1;143(5):136-9
references.pmid: 9725185
references.citation: Vet J. 2008 May;176(2):158-69
references.pmid: 17420149
references.citation: Virus Genes. 2000;20(2):139-42
references.pmid: 10872875
references.citation: Adv Vet Sci. 1963;8:299-333
references.pmid: 14272339
references.citation: Vet Immunol Immunopathol. 2006 Apr 15;110(3-4):279-92
references.pmid: 16325923
references.citation: Arch Virol. 2005 Dec;150(12):2439-52
references.pmid: 16052280
references.citation: Nature. 1969 Mar 15;221(5185):1071-3
references.pmid: 5813153
references.citation: Vet Rec. 1994 Aug 27;135(9):207-9
references.pmid: 7998382
references.citation: Vet Rec. 2007 Jan 13;160(2):58-9
references.pmid: 17220525
references.citation: J Med Entomol. 1989 Jul;26(4):314-7
references.pmid: 2769711
references.citation: Epidemiol Infect. 1988 Dec;101(3):547-64
references.pmid: 3215286
references.citation: J Gen Virol. 1988 Dec;69 ( Pt 12):2981-93
references.pmid: 3199101
references.citation: Res Vet Sci. 1970 Nov;11(6):582-4
references.pmid: 5532269
references.citation: Rev Sci Tech. 1998 Dec;17(3):660-73
references.pmid: 9850537
references.citation: Rev Sci Tech. 1996 Mar;15(1):141-54
references.pmid: 8924700
references.citation: J Gen Virol. 1998 Jun;79 ( Pt 6):1439-43
references.pmid: 9634086
references.citation: Rev Sci Tech. 2006 Apr;25(1):125-35
references.pmid: 16796042
references.citation: Mol Phylogenet Evol. 2007 Nov;45(2):757-62
references.pmid: 17629713
references.citation: J Gen Virol. 2005 Sep;86(Pt 9):2445-2450
references.pmid: 16099902
references.citation: Rev Sci Tech. 1997 Aug;16(2):594-8
references.pmid: 9501373
references.citation: Arch Virol. 2006 Dec;151(12):2475-94
references.pmid: 16817033
references.citation: Vet Rec. 1990 Jan 13;126(2):32-7
references.pmid: 2301109
references.citation: Vet Microbiol. 1998 Apr 30;62(1):1-15
references.pmid: 9659687
references.citation: J Am Vet Med Assoc. 1984 Mar 15;184(6):644-7
references.pmid: 6725096
references.citation: Rev Sci Tech. 1997 Apr;16(1):104-10
references.pmid: 9329110
references.citation: Emerg Infect Dis. 2007 Dec;13(12):1928-31
references.pmid: 18258050
references.citation: J Am Vet Med Assoc. 1981 Sep 1;179(5):441-6
references.pmid: 7309606