title: Hemoglobin-based red blood cell substitutes and nitric oxide.
abstract: Hemoglobin-based oxygen carriers (HBOCs) have been studied for decades as red blood cell substitutes. Profound vasoconstrictor effects have limited the clinical utility of HBOCs and are attributable to avid scavenging of nitric oxide (NO). Inhaling NO can charge the body's stores of NO metabolites without producing hypotension and can prevent systemic hypertension induced when HBOCs are subsequently infused. Concurrent breathing of low NO doses can prevent pulmonary vasoconstriction after HBOC infusion without augmenting plasma methemoglobinemia.
authors.affiliation: Anesthesia Center for Critical Care Research of the Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
authors.forename: Binglan
authors.initials: B
authors.lastname: Yu
authors.forename: Kenneth D
authors.initials: KD
authors.lastname: Bloch
authors.forename: Warren M
authors.initials: WM
authors.lastname: Zapol
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001802:Blood Substitutes / Q000009:adverse effects / Q000494:pharmacology*; D002302:Cardiac Output / Q000187:drug effects; D016166:Free Radical Scavengers; D006454:Hemoglobins / Q000009:adverse effects / Q000494:pharmacology*; D006801:Humans; D006973:Hypertension / Q000139:chemically induced* / Q000378:metabolism / Q000517:prevention & control; D051379:Mice; D009569:Nitric Oxide / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D012756:Sheep; D014655:Vascular Resistance / Q000187:drug effects; D014661:Vasoconstriction / Q000187:drug effects*
chemical_list: D001802:Blood Substitutes; D016166:Free Radical Scavengers; D006454:Hemoglobins; C096798:HBOC 201; D009569:Nitric Oxide
references.citation: ASAIO J. 2001 Sep-Oct;47(5):492-5
references.pmid: 11575824
references.citation: Am J Physiol Heart Circ Physiol. 2006 May;290(5):H1826-9
references.pmid: 16299267
references.citation: BMJ. 2007 Apr 14;334(7597):779
references.pmid: 17383982
references.citation: Circulation. 1991 Jun;83(6):2038-47
references.pmid: 2040056
references.citation: Free Radic Biol Med. 2008 Apr 15;44(8):1506-28
references.pmid: 18261470
references.citation: EuroIntervention. 2008 Mar;3(5):600-9
references.pmid: 19608488
references.citation: J Intern Med. 2003 May;253(5):508-17
references.pmid: 12702028
references.citation: Cardiovasc Res. 2007 Jul 15;75(2):339-48
references.pmid: 17544387
references.citation: J Intern Med. 2008 Jan;263(1):4-15
references.pmid: 18042220
references.citation: JAMA. 2008 May 21;299(19):2304-12
references.pmid: 18443023
references.citation: J Clin Invest. 1998 Jun 1;101(11):2497-505
references.pmid: 9616221
references.citation: Nat Rev Drug Discov. 2008 Feb;7(2):156-67
references.pmid: 18167491
references.citation: Proc Am Thorac Soc. 2006 Apr;3(2):170-2
references.pmid: 16565427
references.citation: N Engl J Med. 1997 Feb 27;336(9):597-604
references.pmid: 9036320
references.citation: Am J Physiol Heart Circ Physiol. 2006 Jul;291(1):H379-84
references.pmid: 16443673
references.citation: Crit Care Clin. 2009 Apr;25(2):373-82, Table of Contents
references.pmid: 19341914
references.citation: Anesthesiology. 2007 Aug;107(2):273-80
references.pmid: 17667572
references.citation: J Am Coll Surg. 2009 Jan;208(1):1-13
references.pmid: 19228496
references.citation: J Hypertens. 2007 Mar;25(3):599-608
references.pmid: 17278977
references.citation: Anesthesiology. 2008 Oct;109(4):675-82
references.pmid: 18813047
references.citation: J Lab Clin Med. 1998 Oct;132(4):313-9
references.pmid: 9794703
references.citation: J Clin Invest. 2005 Dec;115(12):3409-17
references.pmid: 16294219
references.citation: Am J Physiol Heart Circ Physiol. 2009 Feb;296(2):H524-33
references.pmid: 19074675
references.citation: Nat Biotechnol. 1998 Jul;16(7):672-6
references.pmid: 9661203
references.citation: J Clin Invest. 2001 Jul;108(2):279-87
references.pmid: 11457881
references.citation: Clin Pharmacol Ther. 1978 Jan;23(1):73-80
references.pmid: 618711
references.citation: Trans R Soc Trop Med Hyg. 2006 Sep;100(9):817-25
references.pmid: 16527319