Microencapsulation of isoniazid in genipin-crosslinked gelatin-A-κ-carrageenan polyelectrolyte complex.
BACKGROUND
Microspheres of gelatin-A and κ-carrageenan were prepared by using genipin, a naturally occurring crosslinker, and sunflower oil as reaction media.


METHODS
The variations in the size of the microspheres formed by varying the amount of surfactant (0.33-1.0 g/g of polymer), polymer (1.5-3.0 g), and crosslinker (0.2-0.8 mmol) were studied by scanning electron microscopy. The encapsulation of isoniazid was carried out by absorption. The isoniazid content in the prepared microspheres was determined. The release characteristic of isoniazid was also studied at pH values 1.2 and 7.4 by using UV-spectrophotometer.


RESULTS
Characterization of the isoniazid-loaded microspheres was carried out by using Fourier transform infrared spectrophotometry, differential scanning calorimetry, and X-ray diffractometery.
Devi
Nirmala
N
Department of Chemical Sciences, Tezpur University, Napaam, Assam, India.
Maji
Tarun K
TK
D000995:Antitubercular Agents / Q000008:administration & dosage; D002152:Calorimetry, Differential Scanning; D002351:Carrageenan / Q000737:chemistry*; D003432:Cross-Linking Reagents / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry; D004573:Electrolytes / Q000737:chemistry; D005780:Gelatin / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D039823:Iridoids / Q000737:chemistry*; D007538:Isoniazid / Q000008:administration & dosage*; D008863:Microspheres; D010316:Particle Size; D010938:Plant Oils / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D000074242:Sunflower Oil; D013501:Surface-Active Agents / Q000737:chemistry; D014961:X-Ray Diffraction
D000995:Antitubercular Agents; D003432:Cross-Linking Reagents; D004337:Drug Carriers; D004573:Electrolytes; D039823:Iridoids; D010938:Plant Oils; D000074242:Sunflower Oil; D013501:Surface-Active Agents; D002351:Carrageenan; D005780:Gelatin; C007834:genipin; D007538:Isoniazid