Is urinary indolyl-3-acryloylglycine a biomarker for autism with gastrointestinal symptoms?
An autism spectrum disorder (ASD) diagnosis is based on clinical behaviours as there are no validated biological diagnostic tools. Indolyl-3-acryloylglycine (IAG) is a chemical produced by gut microflora and there are conflicting reports as to whether urinary levels are elevated in children with ASD compared with controls. Urinary IAG levels in morning urine samples were statistically significantly higher in children with ASD whose caregivers reported the presence of chronic gastrointestinal (GI) disturbance than children with ASD without chronic GI disturbance. Urinary IAG, however, was not statistically significantly higher in children with ASD, compared with siblings or unrelated controls without ASD.
Wang
Lv
L
Sansom Institute, University of South Australia, South Australia, Australia.
Angley
Manya T
MT
Gerber
Jacobus P
JP
Young
Robyn L
RL
Abarno
Damien V
DV
McKinnon
Ross A
RA
Sorich
Michael J
MJ
D001321:Autistic Disorder / Q000150:complications / Q000652:urine*; D015415:Biomarkers; D002648:Child; D002659:Child Development Disorders, Pervasive / Q000175:diagnosis / Q000652:urine*; D003404:Creatinine / Q000652:urine; D005260:Female; D005767:Gastrointestinal Diseases / Q000150:complications / Q000652:urine*; D005998:Glycine / Q000031:analogs & derivatives* / Q000652:urine; D006801:Humans; D008297:Male
D015415:Biomarkers; C001807:indolylacryloylglycine; D003404:Creatinine; D005998:Glycine