title: Synaptic organization of connections between the temporal cortex and pulvinar nucleus of the tree shrew.
abstract: We examined the synaptic organization of reciprocal connections between the temporal cortex and the dorsal (Pd) and central (Pc) subdivisions of the tree shrew pulvinar nucleus, regions innervated by the medial and lateral superior colliculus, respectively. Both Pd and Pc subdivisions project topographically to 2 separate regions of the temporal cortex; small injections of anterograde tracers placed in either Pd or Pc labeled 2 foci of terminals in the temporal cortex. Pulvinocortical pathways innervated layers I-IV, with beaded axons oriented perpendicular to the cortical surface, where they synapsed with spines that did not contain gamma amino butyric acid (GABA), likely located on the apical dendrites of pyramidal cells. Projections from the temporal cortex to the Pd and Pc originate from layer VI cells, and form small terminals that contact small caliber non-GABAergic dendrites. These results suggest that cortical terminals are located distal to tectopulvinar terminals on the dendritic arbors of Pd and Pc projection cells, which subsequently contact pyramidal cells in the temporal cortex. This circuitry could provide a mechanism for the pulvinar nucleus to activate subcortical visuomotor circuits and modulate the activity of other visual cortical areas. The potential relation to primate tecto-pulvino-cortical pathways is discussed.
authors.affiliation: Department of Anatomical Sciences, University of Louisville, Louisville, KY 40292, USA.
authors.forename: Ranida D
authors.initials: RD
authors.lastname: Chomsung
authors.forename: Haiyang
authors.initials: H
authors.lastname: Wei
authors.forename: Jonathan D
authors.initials: JD
authors.lastname: Day-Brown
authors.forename: Heywood M
authors.initials: HM
authors.lastname: Petry
authors.forename: Martha E
authors.initials: ME
authors.lastname: Bickford
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D001931:Brain Mapping; D002772:Cholera Toxin / Q000378:metabolism; D003911:Dextrans / Q000378:metabolism; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D046529:Microscopy, Electron, Transmission / Q000379:methods; D008959:Models, Neurological; D009434:Neural Pathways / Q000378:metabolism / Q000502:physiology; D020649:Pulvinar / Q000033:anatomy & histology* / Q000378:metabolism / Q000648:ultrastructure; D012235:Rhodamines / Q000378:metabolism; D013266:Stilbamidines / Q000378:metabolism; D013569:Synapses / Q000378:metabolism / Q000502:physiology* / Q000648:ultrastructure; D013702:Temporal Lobe / Q000033:anatomy & histology* / Q000378:metabolism / Q000648:ultrastructure; D014418:Tupaiidae / Q000033:anatomy & histology*
chemical_list: C049774:2-hydroxy-4,4'-diamidinostilbene, methanesulfonate salt; D003911:Dextrans; D012235:Rhodamines; D013266:Stilbamidines; C051311:rhodamine dextran; D002772:Cholera Toxin; D000110:Acetylcholinesterase
references.citation: J Neurosci. 1992 Apr;12(4):1319-34
references.pmid: 1313492
references.citation: J Comp Neurol. 1986 Apr 8;246(2):254-64
references.pmid: 3958252
references.citation: J Comp Neurol. 2008 Sep 1;510(1):24-46
references.pmid: 18615501
references.citation: J Comp Neurol. 1970 Jul;139(3):273-306
references.pmid: 5433195
references.citation: J Physiol. 1998 Aug 1;510 ( Pt 3):829-43
references.pmid: 9660897
references.citation: Science. 1969 Apr 18;164(3877):251-62
references.pmid: 4887561
references.citation: Brain Behav Evol. 2002;59(5-6):262-72
references.pmid: 12207083
references.citation: J Comp Neurol. 1994 Nov 8;349(2):259-68
references.pmid: 7860782
references.citation: J Comp Neurol. 2005 May 2;485(2):87-107
references.pmid: 15776451
references.citation: J Comp Neurol. 1987 Jun 1;260(1):63-75
references.pmid: 3597835
references.citation: Brain Res. 1971 Mar 5;26(2):277-92
references.pmid: 5547178
references.citation: J Comp Neurol. 1993 Oct 1;336(1):1-30
references.pmid: 8254107
references.citation: J Comp Neurol. 1978 Oct 1;181(3):477-512
references.pmid: 690275
references.citation: J Comp Neurol. 1998 Nov 9;401(1):109-28
references.pmid: 9802703
references.citation: J Physiol. 1971 Sep;217(2):473-96
references.pmid: 5097609
references.citation: J Comp Physiol Psychol. 1979 Apr;93(2):247-59
references.pmid: 457949
references.citation: J Comp Neurol. 2006 Aug 20;497(6):847-63
references.pmid: 16802329
references.citation: J Neurophysiol. 2004 Oct;92(4):2185-97
references.pmid: 15140908
references.citation: Eur J Neurosci. 1999 Feb;11(2):469-80
references.pmid: 10051748
references.citation: J Comp Neurol. 1987 May 8;259(2):165-92
references.pmid: 3584556
references.citation: J Comp Neurol. 2004 Jul 26;475(3):406-15
references.pmid: 15221954
references.citation: J Comp Neurol. 1975 Jun 1;161(3):419-58
references.pmid: 50331
references.citation: J Comp Neurol. 2003 Sep 29;464(4):472-86
references.pmid: 12900918
references.citation: J Comp Neurol. 1998 Feb 22;391(4):429-43
references.pmid: 9486823
references.citation: Vis Neurosci. 2000 Jul-Aug;17(4):529-49
references.pmid: 11016573
references.citation: J Comp Neurol. 1982 Oct 20;211(2):193-214
references.pmid: 7174890
references.citation: Z Zellforsch Mikrosk Anat. 1971;114(4):460-81
references.pmid: 5550728
references.citation: J Comp Neurol. 1998 Jun 8;395(3):281-95
references.pmid: 9596524
references.citation: J Anat. 1995 Dec;187 ( Pt 3):583-92
references.pmid: 8586557
references.citation: J Neurophysiol. 1996 Sep;76(3):1367-95
references.pmid: 8890259
references.citation: Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):7121-6
references.pmid: 9618549
references.citation: Brain Res. 1978 Sep 22;153(2):333-9
references.pmid: 687984
references.citation: Exp Brain Res. 2010 Jan;200(1):3-24
references.pmid: 19568736
references.citation: J Comp Neurol. 1979 Oct 15;187(4):655-78
references.pmid: 114556
references.citation: J Hirnforsch. 1991;32(2):165-73
references.pmid: 1724257
references.citation: Trends Neurosci. 2006 Jun;29(6):307-16
references.pmid: 16713635
references.citation: J Comp Neurol. 2003 Dec 22;467(4):607-27
references.pmid: 14624492
references.citation: J Comp Neurol. 2009 Aug 20;515(6):647-63
references.pmid: 19496169
references.citation: J Comp Neurol. 2005 Apr 25;485(1):11-31
references.pmid: 15776444
references.citation: J Comp Neurol. 1999 Apr 5;406(2):221-50
references.pmid: 10096608
references.citation: J Comp Neurol. 2009 Sep 1;516(1):20-35
references.pmid: 19562768
references.citation: J Comp Neurol. 1983 Jun 20;217(2):137-57
references.pmid: 6886048
references.citation: J Comp Neurol. 1979 Nov 1;188(1):179-99
references.pmid: 115908
references.citation: Science. 1969 Feb 28;163(3870):895-902
references.pmid: 5763873
references.citation: J Comp Neurol. 1974 Jul;156(2):207-37
references.pmid: 4424699
references.citation: Proc R Soc Lond B Biol Sci. 1969 Mar 11;172(1027):173-85
references.pmid: 4388108
references.citation: J Comp Neurol. 2003 Dec 22;467(4):593-606
references.pmid: 14624491
references.citation: J Comp Neurol. 1980 Sep 1;193(1):1-40
references.pmid: 7430424
references.citation: J Comp Neurol. 1988 Jul 1;273(1):67-86
references.pmid: 2463276
references.citation: Brain Res. 1983 Nov 21;279(1-2):258-61
references.pmid: 6640346
references.citation: Brain Behav Evol. 1974;9(4):264-79
references.pmid: 4218798
references.citation: Neuron. 2002 Feb 28;33(5):779-88
references.pmid: 11879654
references.citation: J Comp Neurol. 1997 Oct 20;387(2):266-78
references.pmid: 9336228
references.citation: J Comp Neurol. 2003 Jun 2;460(3):394-409
references.pmid: 12692857
references.citation: J Comp Neurol. 1981 Aug 1;200(2):231-54
references.pmid: 7287920
references.citation: Anat Rec (Hoboken). 2009 Jul;292(7):994-1027
references.pmid: 19462403
references.citation: J Comp Neurol. 1984 Dec 10;230(3):337-51
references.pmid: 6520238
references.citation: Neuron. 2002 Jan 17;33(2):163-75
references.pmid: 11804565
references.citation: Somatosens Res. 1985;3(1):1-31
references.pmid: 4070891
references.citation: Exp Brain Res. 1996 Apr;109(1):63-70
references.pmid: 8740209
references.citation: J Comp Neurol. 1977 May 15;173(2):389-416
references.pmid: 853144
references.citation: J Comp Neurol. 1973 Aug;150(4):393-440
references.pmid: 4727888
references.citation: Prog Brain Res. 2008;171:467-73
references.pmid: 18718342
references.citation: J Comp Neurol. 2008 Mar 10;507(2):1209-27
references.pmid: 18181153
references.citation: J Comp Physiol Psychol. 1975 Dec;89(10):1109-35
references.pmid: 811692
references.citation: J Comp Physiol Psychol. 1971 Jan;74(1):Suppl 2:1-29
references.pmid: 5577168
references.citation: Brain Res Rev. 2007 Oct;55(2):285-96
references.pmid: 17433837
references.citation: Proc Natl Acad Sci U S A. 1997 Feb 18;94(4):1517-20
references.pmid: 9037085
references.citation: Brain Res. 1984 Apr 23;298(1):171-4
references.pmid: 6202365
references.citation: J Comp Neurol. 2001 Aug 6;436(4):508-19
references.pmid: 11447593
references.citation: Brain Res. 1985 Aug 5;340(1):163-70
references.pmid: 4027643
references.citation: Exp Brain Res. 1990;80(2):387-96
references.pmid: 2358052
references.citation: J Comp Neurol. 2000 Apr 10;419(3):306-19
references.pmid: 10723007
references.citation: J Comp Neurol. 1990 Dec 15;302(3):500-14
references.pmid: 1702114
references.citation: J Neurophysiol. 1976 Mar;39(2):354-69
references.pmid: 815517
references.citation: Cell Tissue Res. 1982;224(1):207-23
references.pmid: 7094009
references.citation: J Comp Neurol. 2005 Apr 18;484(4):458-73
references.pmid: 15770654