title: Disubstituted 4(3H) quinazolones: a novel class of antitumor agents.
abstract: A series of disubstituted 4(3H) quinazolines were designed for potential application in tumors. Firstly, N-benzoyl anthranilic acid is formed, which undergoes cyclization in the presence of pyridine. Subsequently, nucleophilic attack by semicarbazide on the carbonyl carbon gives 2-substituted 3-carbamido 4(3H) quinazolones, which gives final compound with appropriate substitution. The final as well as intermediate products were confirmed by NMR, FT-IR, and mass spectrometry. In vitro toxicity was performed with different cell lines and showed that the connection of hydrophilic styryl to quinazoline moiety increases its efficacy.
authors.affiliation: Department of Chemistry, Meerut College/MIET, Meerut, India.
authors.forename: Vikas
authors.initials: V
authors.lastname: Srivastava
authors.forename: Anand Mohan
authors.initials: AM
authors.lastname: Srivastava
authors.forename: Anjani K
authors.initials: AK
authors.lastname: Tiwari
authors.forename: Rakesh
authors.initials: R
authors.lastname: Srivastava
authors.forename: Rajbala
authors.initials: R
authors.lastname: Sharma
authors.forename: Himanshu
authors.initials: H
authors.lastname: Sharma
authors.forename: Vinay K
authors.initials: VK
authors.lastname: Singh
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy; D021281:Quantitative Structure-Activity Relationship; D011799:Quinazolines / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity
chemical_list: D000970:Antineoplastic Agents; D011799:Quinazolines