title: A hypervariable STR polymorphism in the complement factor I (CFI) gene: Asian-specific alleles.
abstract: In this study, a short tandem repeat (STR) polymorphism in intron 7 of the human complement factor I (CFI) gene was studied in 637 DNA samples obtained from African, German, Thai, and Japanese populations and German and Japanese families. A total of 41 alleles were observed and classified into two groups, L and H, based on size differences. Group H, which consisted of 16 alleles, was observed only in Thai and Japanese populations at frequencies of 0.162 and 0.116, respectively, and was strongly associated with c.1217A in exon 11 (CFI*Ah). The heterozygosity values ranged from 0.89 in German to 0.93 in Thai populations. This STR would be a useful supplementary marker for forensic individualization.
authors.affiliation: Division of Legal Medicine, Faculty of Medicine, Tottori University, Yonago, 683-8503, Japan. yuasai@med.tottori-u.ac.jp
authors.forename: Isao
authors.initials: I
authors.lastname: Yuasa
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Irizawa
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Nishimukai
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Fukumori
authors.forename: Kazuo
authors.initials: K
authors.lastname: Umetsu
authors.forename: Nori
authors.initials: N
authors.lastname: Nakayashiki
authors.forename: Naruya
authors.initials: N
authors.lastname: Saitou
authors.forename: Lotte
authors.initials: L
authors.lastname: Henke
authors.forename: Jürgen
authors.initials: J
authors.lastname: Henke
mesh_terms: D017244:Complement Factor I / Q000235:genetics*; D005091:Exons; D005787:Gene Frequency; D006239:Haplotypes; D006579:Heterozygote; D006801:Humans; D007438:Introns; D015810:Linkage Disequilibrium; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D044469:Racial Groups / Q000235:genetics; D020080:Tandem Repeat Sequences
chemical_list: D017244:Complement Factor I
references.citation: Forensic Sci Int Genet. 2008 Jun;2(3):e49-52
references.pmid: 19083816
references.citation: Nat Genet. 2007 Oct;39(10):1251-5
references.pmid: 17828266
references.citation: Int J Legal Med. 2007 Mar;121(2):85-9
references.pmid: 16642351
references.citation: Evol Bioinform Online. 2007 Feb 23;1:47-50
references.pmid: 19325852
references.citation: Forensic Sci Int Genet. 2008 Dec;3(1):7-13
references.pmid: 19083860
references.citation: Trends Genet. 2007 Sep;23(9):432-9
references.pmid: 17655965
references.citation: Int J Legal Med. 1997;110(4):175-6
references.pmid: 9274938
references.citation: J Hum Genet. 2008;53(11-12):1016-1021
references.pmid: 18825487
references.citation: Int J Legal Med. 2008 Jan;122(1):67-71
references.pmid: 17273877
references.citation: Biol Lett. 2007 Apr 22;3(2):218-23
references.pmid: 17301009
references.citation: Int J Legal Med. 1998;111(5):267-72
references.pmid: 9728756
references.citation: Int J Legal Med. 2009 May;123(3):259-61
references.pmid: 19156434