Underpowered clinical trials: time for a change.
van Kleef
Maarten
M
Maastricht University Medical Centre, Department of Anesthesiology and Pain Management, Mail Box 5800, 6202 AZ Maastricht, The Netherlands Maastricht University Medical Centre, Department of Clinical Epidemiology and Medical, Technology Assessment, The Netherlands.
Kessels
Alfons G H
AGH
D004311:Double-Blind Method; D006801:Humans; D017116:Low Back Pain / Q000628:therapy; D017063:Outcome Assessment, Health Care; D016032:Randomized Controlled Trials as Topic; D012107:Research Design; D018401:Sample Size; D013997:Time Factors
Kvarstein G, Måwe L, Indahl A, Hol PK, Tennøe B, Digernes R, Stubhaug A, Tornnessen TI, Breivek H. A randomised double blind controlled trial of intra-annular radiofrequency thermal disc therapy – a 12 month follow-up. Pain. 2009;145:279-286.
Luoma K, Riihimaki H, Luukkonen R, Raininko R, Viikari-Juntura E, Lamminen A. Low back pain in relation to lumbar disc degeneration. Spine. 2000;25:487-492.
Miller JA, Schmatz C, Schultz AB. Lumbar disc degeneration: correlation with age, sex, and spine level in 600 autopsy specimens. Spine. 1988;13:173-178.
O'Brien PC. Procedures for comparing samples with multiple endpoints. Biometrics. 1984;40:1079-1087.
Pauza KJ, Howell S, Dreyfuss P, Peloza JH, Dawson K, Bogduk N. A randomized, placebo-controlled trial of intradiscal electrothermal therapy for the treatment of discogenic low back pain [see comment]. Spine J. 2004;4:27-35.
Schellings R, Kessels AG, ter Riet G, Sturmans F, Widdershoven GA, Knottnerus JA. Indications and requirements for the use of prerandomization. J Clin Epidemiol. 2009;62:393-399.
Snapinn SM. Monitoring clinical trials with a conditional probability stopping rule. Stat Med. 1992;11:659-672.