title: [Intestinal failure: from adaptation to transplantation].
abstract: Optimised Home Parenteral Nutrition is still, after 35 years of progress, the << gold standard >> of benign but chronic Intestinal Failure. A better recognition of chronic Intestinal Failure, in its multiple facets, is warranted for a better approach of associated treatment to Home Parenteral Nutrition, i.e., intestinal trophic factors (growth hormone, Glucagon Like Peptide-2), rehabilitative surgery (reestablishment of colonic continuity, reverse jejunal segment in severe short gut type II) and/or reconstructive surgery (intestinal transplantation for end stage intestinal failure patients). Boundaries of permanent, judged irreversible, intestinal failure will be certainly modified in the following years by combining the various and effective therapies which optimise management by ameliorating absorption of the remnant short gut. The work done on short bowel syndrome in the past 20 years should be done in the next years for chronic-intestinal - pseudo-obstruction patients presenting with intestinal failure on a large European scale because chronic-intestinal - pseudo-obstruction is a group of heterogeneous but rare intestinal diseases. Intestinal transplantation is now a mature therapy with formal indication especially in case of Home Parenteral Nutrition failure (mainly Home Parenteral Nutrition-associated severe liver disease) where combined Liver-intestine transplantation is indicated before end-stage liver failure occurs. For high-risk patients, "preemptive" indication for intestinal transplantation alone will be discussed before home parenteral nutrition complications occur. No doubt that, for improving overall outcome in intestinal failure patients, reference centres should have in expert hands the whole spectrum of medicosurgical therapies for intestinal failure.
authors.affiliation: Service de Gastroentérologie et Assistance Nutritive, Centre Agréé de Nutrition Parentérale à Domicile, Labellisé Pour les Maladies Intestinales Rares et la Transplantation Intestinale, Pôle des Maladies de l'Appareil Digestif, Hôpital Beaujon, Assistance Publique-Hôpitaux de Paris, 92110 Clichy, France. bernard.messing@bjn.aphp.fr
authors.forename: B
authors.initials: B
authors.lastname: Messing
authors.forename: O
authors.initials: O
authors.lastname: Corcos
authors.forename: A
authors.initials: A
authors.lastname: Amiot
authors.forename: F
authors.initials: F
authors.lastname: Joly
mesh_terms: D000222:Adaptation, Physiological; D006801:Humans; D007410:Intestinal Diseases / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D007422:Intestines / Q000637:transplantation*; D010288:Parenteral Nutrition