title: Quality of life and functional outcome at 3, 6 and 12 months after acute necrotising pancreatitis.
abstract: OBJECTIVE
  To prospectively determine the quality of life and functional outcome at 3, 6 and 12 months following acute necrotising pancreatitis.
  
  
  METHODS
  Thirty-one consecutive patients with acute necrotising pancreatitis requiring intensive care in our hospital were identified. Survivors were assessed at 3, 6 and 12 months following hospital discharge by an investigator blinded to their previous treatment. Health-related quality of life was assessed by the Short Form 36 (SF-36) questionnaire and functional outcome by the six minute walk test.
  
  
  RESULTS
  Twenty-one patients (68%) survived to leave hospital. The median score for the physical function domain increased from 32 at 3 months to 38 and 12 months (P = 0.013), but remained lower than the score in the normal population of 88 (P < 0.001). The median physical component summary score increased from 33 at 3 months to 40 at 12 months (P = 0.030), but remained lower than the score in the normal population of 50 (P = 0.009). Between 3 and 12 months the median distance walked in 6-min increased from 358 to 424 m (P = 0.021), but remained lower than the predicted distance of 503 m (P = 0.014).
  
  
  CONCLUSIONS
  In the first year after acute necrotising pancreatitis patients showed improvement in their physical components of quality of life and in their physical function, but their outcome at 12 months was still poor compared to the general population. This patient group in particular may benefit from a structured rehabilitation programme continuing after hospital discharge.
authors.affiliation: Department of Perioperative and Critical Care, Freeman Hospital, High Heaton, Newcastle upon Tyne, NE7 7DN, UK. stephen.wright@nuth.nhs.uk
authors.forename: Stephen E
authors.initials: SE
authors.lastname: Wright
authors.forename: Rajiv
authors.initials: R
authors.lastname: Lochan
authors.forename: Karen
authors.initials: K
authors.lastname: Imrie
authors.forename: Catherine
authors.initials: C
authors.lastname: Baker
authors.forename: Ian D
authors.initials: ID
authors.lastname: Nesbitt
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Kilner
authors.forename: Richard M
authors.initials: RM
authors.lastname: Charnley
mesh_terms: D000203:Activities of Daily Living / Q000523:psychology; D000328:Adult; D000368:Aged; D003422:Critical Care / Q000458:organization & administration; D004739:England; D005080:Exercise Test; D005260:Female; D006304:Health Status; D006306:Health Surveys; D006801:Humans; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D019283:Pancreatitis, Acute Necrotizing / Q000503:physiopathology / Q000523:psychology / Q000628:therapy; D011446:Prospective Studies; D011788:Quality of Life / Q000523:psychology; D016037:Single-Blind Method; D018709:Statistics, Nonparametric; D011795:Surveys and Questionnaires; D017741:Survivors / Q000523:psychology / Q000706:statistics & numerical data; D016138:Walking
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