title: Successful treatment of severe iatrogenic calcinosis cutis with intravenous sodium thiosulfate in a child affected by T-acute lymphoblastic leukemia.
abstract: Sodium thiosulfate has been successfully used to treat calcyphilaxis in adults and children, but its effect on iatrogenic calcinosis cutis secondary to extravasation of calcium solutions is less known. We describe a 5-year-old boy with acute lymphoblastic leukemia who developed severe calcinosis cutis in the right forearm and hand, and in the left leg and foot after extravasation of calcium gluconate during treatment for tumor-lysis-syndrome-related hypocalcaemia. Surgical debridement, local wound care, hyperbaric oxygen therapy, and sodium thiosulfate infusion achieved a complete healing of all lesions in an eight-month period with a short discontinuation of chemotherapy. No functional or sensitive impairment remained.
authors.affiliation: Clinic of Pediatric Oncology-Hematology, Department of Pediatrics, University of Padova, Padova, Italy. rcolombatti@gmail.com
authors.forename: Colombatti
authors.initials: C
authors.lastname: Raffaella
authors.forename: Calò
authors.initials: C
authors.lastname: Annapaola
authors.forename: Iacopetti
authors.initials: I
authors.lastname: Tullio
authors.forename: Rosolen
authors.initials: R
authors.lastname: Angelo
authors.forename: Lombardi
authors.initials: L
authors.lastname: Giuseppe
authors.forename: Cesaro
authors.initials: C
authors.lastname: Simone
mesh_terms: D002114:Calcinosis / Q000188:drug therapy* / Q000209:etiology; D002125:Calcium Gluconate / Q000009:adverse effects; D002614:Chelating Agents / Q000008:administration & dosage*; D002675:Child, Preschool; D005119:Extravasation of Diagnostic and Therapeutic Materials / Q000150:complications; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D054218:Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / Q000628:therapy*; D012871:Skin Diseases / Q000188:drug therapy* / Q000209:etiology; D013885:Thiosulfates / Q000008:administration & dosage*
chemical_list: D002614:Chelating Agents; D013885:Thiosulfates; C017717:sodium thiosulfate; D002125:Calcium Gluconate