title: Solifenacin for therapy resistant overactive bladder.
abstract: OBJECTIVE
  With the availability of the once daily oral antimuscarinic agent solifenacin (5 mg), we started to use it for therapy resistant overactive bladder. We evaluate side effects and efficacy.
  
  
  METHODS
  We reviewed the charts of children treated with solifenacin succinate between August 2005 and August 2008 for therapy resistant OAB. Incontinence was compared at study entry and study end.
  
  
  RESULTS
  During the study period 84 boys and 54 girls with a mean age of 9 years 2 months received solifenacin. Mean followup was 22.59 months. While on solifenacin, side effects were observed in 9 of 138 patients (6.5%). Efficacy evaluation included only 99 patients after 3 months of therapy. Mean voided volume after treatment was 253.5 ml, showing a significant 25% increase compared to the mean value before therapy (50.5 vs 203.0 ml, p <0.01). Of the patients 84 (85%) were considered responders, including 45 who were completely dry (full response) and 39 who had fewer nocturnal enuresis or diurnal incontinence symptoms (partial response). Of these 39 patients 17 became dry during the day, 1 became dry during the night and 21 had more than a 50% decrease in nocturnal enuresis and diurnal incontinence symptoms. In 15 patients the outcome was unchanged or worse (no response).
  
  
  CONCLUSIONS
  In this group of children with OAB we noted favorable results with solifenacin with few side effects. Despite the uncontrolled, retrospective study design the effect is attributable to solifenacin intake.
authors.affiliation: Division of Pediatric Urology, Department of Urology, Ghent University Hospital, Ghent, Belgium. Piet.hoebeke@ugent.be
authors.forename: Piet
authors.initials: P
authors.lastname: Hoebeke
authors.forename: Jan
authors.initials: J
authors.lastname: De Pooter
authors.forename: Karel
authors.initials: K
authors.lastname: De Caestecker
authors.forename: Ann
authors.initials: A
authors.lastname: Raes
authors.forename: Joke
authors.initials: J
authors.lastname: Dehoorne
authors.forename: Erik
authors.initials: E
authors.lastname: Van Laecke
authors.forename: Johan
authors.initials: J
authors.lastname: Vande Walle
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D018727:Muscarinic Antagonists / Q000627:therapeutic use*; D011812:Quinuclidines / Q000627:therapeutic use*; D012189:Retrospective Studies; D000069464:Solifenacin Succinate; D044005:Tetrahydroisoquinolines / Q000627:therapeutic use*; D016896:Treatment Outcome; D053201:Urinary Bladder, Overactive / Q000188:drug therapy*
chemical_list: D018727:Muscarinic Antagonists; D011812:Quinuclidines; D044005:Tetrahydroisoquinolines; D000069464:Solifenacin Succinate