WEbcoli: an interactive and asynchronous web application for in silico design and analysis of genome-scale E.coli model.
CONCLUSIONS
WEbcoli is a WEb application for in silico designing, analyzing and engineering Escherichia coli metabolism. It is devised and implemented using advanced web technologies, thereby leading to enhanced usability and dynamic web accessibility. As a main feature, the WEbcoli system provides a user-friendly rich web interface, allowing users to virtually design and synthesize mutant strains derived from the genome-scale wild-type E.coli model and to customize pathways of interest through a graph editor. In addition, constraints-based flux analysis can be conducted for quantifying metabolic fluxes and charactering the physiological and metabolic states under various genetic and/or environmental conditions.


BACKGROUND
WEbcoli is freely accessible at http://webcoli.org.


BACKGROUND
cheld@nus.edu.sg.
Jung
Tae-Sung
TS
Department of Information Industrial Engineering, CBITRC, Chungbuk National University, Cheongju Chungbuk 361-763, Korea.
Yeo
Hock Chuan
HC
Reddy
Satty G
SG
Cho
Wan-Sup
WS
Lee
Dong-Yup
DY
D019295:Computational Biology / Q000379:methods*; D030541:Databases, Genetic; D004926:Escherichia coli / Q000235:genetics* / Q000378:metabolism; D016680:Genome, Bacterial; D020407:Internet; D012984:Software