BARD1 may be renamed ROW1 because it functions mainly as a REPRESSOR OF WUSCHEL1.
Human BRCA1 (BRreast CAncer susceptible gene1) is known to involve in cell cycle control, transcriptional regulation, DNA recombination, DNA repair and many other processes. hBARD1 (BRCA1-Associated Ring Domain 1) forms heterodimer via its N-terminal conserved RING domain with BRCA1. In Arabidopsis, two genes, At4g21070 and At1g04020, that share N-terminal RING domain and C-terminal BRCT (for BRCA1 C-Terminal) domains with no substantial similarities for other motifs, have been identified. AtBRCA1 was induced by gamma-ray while AtBARD1 was required for DNA repair. Recently, we find that AtBARD1 may function to confine WUS transcription in the shoot apical meristem organization center, together with the ATPase-dependent chromatin remodeling factor, SYD. In bard1-3 Arabidopsis knockout mutant, WUS was released to the outer layers and expressed at extremely high level comparing to wild-type. Our data suggest that BARD1 mainly function as a REPRESSOR OF WUSCHEL1 (ROW1). Extensive motif analyses carried out here showed that ROW1 possesses substantial sequence identity with a reported transcription repressor, MLL and also a potential PHD domain which recognizes histone tail codes, in its uncharacterized middle region. We suggest that ROW1 represses transcription in a chromatin-related mechanism.
Han
Pei
P
The National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University, Beijing, China.
Zhu
Yu-Xian
YX
Plant J. 1993 Jul;4(1):137-50
8106082
Nat Rev Cancer. 2007 Dec;7(12):937-48
18034184
Cell. 2000 Sep 1;102(5):549-52
11007473
Nat Genet. 2000 Jan;24(1):88-91
10615135
Nature. 2006 Jul 6;442(7098):96-9
16728974
Biochim Biophys Acta. 2006 Jan;1765(1):67-73
16249056
Cell. 2004 Jan 23;116(2):259-72
14744436
EMBO J. 2006 Sep 20;25(18):4326-37
16957774
Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8342-7
12829790
Cell. 2001 Apr 6;105(1):149-60
11301010
Nature. 2006 Jul 6;442(7098):91-5
16728978
Science. 1994 Oct 7;266(5182):66-71
7545954
Nature. 2006 Jul 6;442(7098):86-90
16728976
J Biol Chem. 1999 Apr 16;274(16):11334-8
10196224
Nucleic Acids Res. 2003 Feb 15;31(4):1148-55
12582233
Science. 2007 Jun 22;316(5832):1718-23
17510324
Plant J. 2001 Oct;28(1):27-39
11696184
FEBS Lett. 1997 Jan 2;400(1):25-30
9000507
Proc Natl Acad Sci U S A. 1990 Mar;87(6):2112-6
2107543
Proc Natl Acad Sci U S A. 2004 Feb 24;101(8):2357-62
14983014
Cell. 2003 Jul 11;114(1):99-111
12859901
Cell. 2000 Jul 21;102(2):257-65
10943845
Plant Cell. 2008 Jun;20(6):1482-93
18591352
Science. 2000 Jul 28;289(5479):617-9
10915624
Plant Mol Biol. 1996 Feb;30(3):439-53
8605297
Genomics. 2001 May 15;74(1):79-88
11374904
Nature. 2006 Jul 6;442(7098):100-3
16728977
Genes Dev. 2005 Apr 15;19(8):992-1003
15833920
Nat Genet. 1996 Dec;14(4):430-40
8944023
Curr Opin Genet Dev. 2002 Feb;12(1):86-91
11790560
Curr Opin Cell Biol. 2003 Jun;15(3):345-50
12787778
Plant Cell. 2003 Jun;15(6):1281-95
12782723
Oncogene. 2002 Jul 18;21(31):4849-54
12101424
Oncogene. 1997 Jul 10;15(2):143-57
9244350
Nat Rev Cancer. 2006 May;6(5):382-91
16633366
Nat Rev Cancer. 2004 Sep;4(9):665-76
15343273
Cell. 2000 Mar 17;100(6):635-44
10761929
Plant Cell. 2006 May;18(5):1188-98
16603652