title: Effect of plasma lipoproteins and their complexes with polysaccharides on interleukin-1beta concentration in macrophages of mice with HA-1 ascitic hepatoma.
abstract: Experiments on cultured peritoneal macrophage from mice with HA-1 ascitic hepatoma showed that plasma lipoproteins present in the incubation medium decreased intracellular concentration of interleukin-1beta. These changes were most pronounced for high-density lipoproteins (alone or in combination with cortisol). Bacterial and yeast polysaccharides had little effect on interleukin-1beta concentration in macrophages. Addition of polysaccharides in combination with lipoproteins was followed by a 2-3-fold decrease in interleukin-1beta concentration. A combination of polysaccharides and high-density lipoproteins had the strongest effect. These properties of plasma lipoproteins should be taken into account in the correction of macrophage function during tumor growth.
authors.affiliation: Institute of Biochemistry, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia. plm@soramn.ru
authors.forename: L M
authors.initials: LM
authors.lastname: Polyakov
authors.forename: D V
authors.initials: DV
authors.lastname: Sumenkova
authors.forename: L E
authors.initials: LE
authors.lastname: Panin
mesh_terms: D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000378:metabolism*; D002478:Cells, Cultured; D003470:Culture Media; D006854:Hydrocortisone / Q000378:metabolism; D053583:Interleukin-1beta / Q000378:metabolism*; D042541:Intracellular Space / Q000378:metabolism; D008074:Lipoproteins / Q000378:metabolism*; D008075:Lipoproteins, HDL / Q000378:metabolism; D008077:Lipoproteins, LDL / Q000378:metabolism; D008114:Liver Neoplasms, Experimental / Q000378:metabolism*; D008264:Macrophages / Q000166:cytology / Q000378:metabolism*; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D010529:Peritoneal Cavity / Q000166:cytology; D011134:Polysaccharides / Q000378:metabolism*; D011135:Polysaccharides, Bacterial / Q000378:metabolism
chemical_list: D003470:Culture Media; D053583:Interleukin-1beta; D008074:Lipoproteins; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D011134:Polysaccharides; D011135:Polysaccharides, Bacterial; D006854:Hydrocortisone