title: Multi-fiber reconstruction from DW-MRI using a continuous mixture of hyperspherical von Mises-Fisher distributions.
abstract: Multi-fiber reconstruction has attracted immense attention lately in the field of diffusion weighted MRI analysis. Several mathematical models have been proposed in literature but there is still scope for improvement. The key issues of importance in multi-fiber reconstruction are, fiber detection accuracy, robustness to noise and computational efficiency. To this end, we propose a novel mathematical model for representing the MR signal attenuation in the presence of multiple fibers at a single voxel and estimate the parameters of this model given the diffusion weighted MRI data. Our model for the diffusion MR signal consists of a continuous mixture of Hyperspherical von Mises-Fisher distributions. Being a continuous mixture, our model does not require the specification of the number of mixture components. We present a closed form expression for this continuous mixture that leads to a computationally efficient implementation. To validate our model we present extensive results on both synthetic and real data (human and rat brain) and demonstrate that even in presence of noise, our model clearly outperforms the state-of-the-art methods in fiber orientation estimation while maintaining a substantial computational advantage.
authors.affiliation: Dept. of CISE, University of Florida, Gainesville, FL, USA.
authors.forename: Ritwik
authors.initials: R
authors.lastname: Kumar
authors.forename: Baba C
authors.initials: BC
authors.lastname: Vemuri
authors.forename: Fei
authors.initials: F
authors.lastname: Wang
authors.forename: Tanveer
authors.initials: T
authors.lastname: Syeda-Mahmood
authors.forename: Paul R
authors.initials: PR
authors.lastname: Carney
authors.forename: Thomas H
authors.initials: TH
authors.lastname: Mareci
mesh_terms: D000465:Algorithms; D001185:Artificial Intelligence; D001921:Brain / Q000033:anatomy & histology*; D016000:Cluster Analysis; D003198:Computer Simulation; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008959:Models, Neurological; D015233:Models, Statistical; D009413:Nerve Fibers, Myelinated / Q000648:ultrastructure*; D010363:Pattern Recognition, Automated / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D016008:Statistical Distributions