Response to oxaliplatin with cetuximab in minor salivary gland adenoid cystic carcinoma.
Esophageal localization of adenoid cystic carcinoma of minor salivary glands is rare; it may occur in the early to mid-sixties' age group and is more frequently encountered in men than women. In the majority of cases, it arises from subepithelial glands of the middle to lower third of the esophagus, a similar distribution as squamous cell carcinoma. Prognosis depends mostly on tumor staging and resectability, which represents the only chance of cure. Due to the extreme rarity of this condition, there is limited experience with systemic therapy for advanced disease. We report a case of a patient with metastatic primary esophageal adenoid cystic carcinoma progressing on platinum- and irinotecan-based regimens, who achieved an objective response with oxaliplatin-based chemotherapy in combination with cetuximab.
De Dosso
Sara
S
Division of Medical Oncology Oncology, Institute of Southern Switzerland, Bellinzona, Switzerland. sara.dedosso@eoc.ch
Mazzucchelli
Luca
L
Ghielmini
Michele
M
Saletti
Piercarlo
P
D000911:Antibodies, Monoclonal / Q000008:administration & dosage; D061067:Antibodies, Monoclonal, Humanized; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000032:analysis; D003528:Carcinoma, Adenoid Cystic / Q000737:chemistry / Q000188:drug therapy* / Q000556:secondary*; D000068818:Cetuximab; D066246:ErbB Receptors / Q000032:analysis; D004938:Esophageal Neoplasms / Q000737:chemistry / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009944:Organoplatinum Compounds / Q000008:administration & dosage; D000077150:Oxaliplatin; D012468:Salivary Gland Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D016896:Treatment Outcome
D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D014408:Biomarkers, Tumor; D009944:Organoplatinum Compounds; D000077150:Oxaliplatin; D066246:ErbB Receptors; D000068818:Cetuximab