title: Synthesis and SAR of 1,4,5,6-tetrahydropyridazines as potent cannabinoid CB1 receptor antagonists.
abstract: The synthesis and structure-activity relationship studies of 1,4,5,6-tetrahydropyridazines are described. The target compounds 3-5 represent a novel class of potent and selective CB1 receptor antagonists.
authors.affiliation: Solvay Pharmaceuticals, Chemical Design and Synthesis Unit, Research Laboratories, C. J. van Houtenlaan 36, 1381 CP Weesp, The Netherlands. jos.lange@solvay.com
authors.forename: Jos H M
authors.initials: JH
authors.lastname: Lange
authors.forename: Arnold P
authors.initials: AP
authors.lastname: den Hartog
authors.forename: Martina A W
authors.initials: MA
authors.lastname: van der Neut
authors.forename: Bernard J
authors.initials: BJ
authors.lastname: van Vliet
authors.forename: Chris G
authors.initials: CG
authors.lastname: Kruse
mesh_terms: D000818:Animals; D016466:CHO Cells; D006224:Cricetinae; D003412:Cricetulus; D006801:Humans; D011724:Pyridazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D043884:Receptor, Cannabinoid, CB1 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D011724:Pyridazines; D043884:Receptor, Cannabinoid, CB1