title: Effect of prepartum dry cow antibiotic treatment in dairy heifers on udder health and milk production.
abstract: A high percentage of heifers calve with intramammary infections. One of the measures available to control intramammary infections is treatment with antibiotics before calving. In this study, the effects of prepartum treatment of nonlactating heifers with a 600-mg cloxacillin dry cow treatment on the prevalence of culture-positive milk samples at calving and 10 to 14 d in milk (DIM), the incidence of clinical mastitis, somatic cell count (SCC), and milk production during first lactation were quantified. A total of 184 heifers on 13 dairy farms were treated with antibiotics 8 to 10 wk before the expected calving date. Another 185 heifers served as untreated controls. Coagulase-negative staphylococci were the most frequently isolated group of bacteria in the treatment and control groups at calving (32 and 42%), and at 10 to 14 DIM (15 and 19%), respectively. The prevalence of minor pathogens at calving was lower in the treatment group compared with the control group (34 and 43%, respectively). Staphylococcus aureus was the most frequently isolated major pathogen in the treated and control heifers at calving (4 and 5%) and at 10 to 14 DIM (2 and 3%), respectively. The prevalence of major pathogens was lower in the treated heifers at 10 to 14 DIM compared with the control group (4 and 6%, respectively). Cumulative incidence risk of clinical mastitis during the lactation was 9 and 18% in the treatment and control groups, respectively. Treatment with cloxacillin 8 to 10 wk before calving resulted in a lower prevalence of culture-positive milk samples at calving and lower quarter milk SCC in early lactation [30,000 +/- 4,600 (standard deviation) cells/mL in treated heifers versus 40,000 +/- 4,600 cells/mL in control heifers], and was associated with lower average test-day SCC (55,000 +/- 1,400 cells/mL in treated heifers versus 71,000 +/- 1,500 cells/mL in control heifers) and lower incidence of clinical mastitis throughout lactation. The improved udder health resulted in a higher average test-day milk production in the first lactation (24.5 +/- 3.2 kg in treated heifers versus 23.6 +/- 3.1 kg in control heifers). Dairy farms with heifer mastitis problems need to analyze their mastitis management. Prepartum treatment of heifers with dry cow antibiotics may be helpful by decreasing the prevalence of mastitis-causing pathogens at calving and at 10 to 14 DIM.
authors.affiliation: GD Animal Health Service Ltd., Deventer, the Netherlands. o.sampimon@gddeventer.com
authors.forename: O C
authors.initials: OC
authors.lastname: Sampimon
authors.forename: S
authors.initials: S
authors.lastname: De Vliegher
authors.forename: H W
authors.initials: HW
authors.lastname: Barkema
authors.forename: J
authors.initials: J
authors.lastname: Sol
authors.forename: T J G M
authors.initials: TJ
authors.lastname: Lam
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001419:Bacteria; D001424:Bacterial Infections / Q000188:drug therapy / Q000382:microbiology / Q000517:prevention & control / Q000662:veterinary*; D002417:Cattle; D003023:Cloxacillin / Q000627:therapeutic use*; D003612:Dairying; D005260:Female; D015994:Incidence; D007774:Lactation / Q000187:drug effects*; D008321:Mammary Glands, Animal / Q000382:microbiology / Q000502:physiology*; D008414:Mastitis, Bovine / Q000188:drug therapy* / Q000382:microbiology / Q000517:prevention & control; D008892:Milk / Q000166:cytology / Q000378:metabolism; D011247:Pregnancy; D012307:Risk Factors; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D003023:Cloxacillin