Initial response to treatment was highly associated with the prognosis of childhood rhabdomyosarcoma: a retrospective analysis of a single center experience in Korea.
OBJECTIVE
Following the introduction of a multimodal approach to diagnosis and treatment, the prognosis of rhabdomyosarcoma (RMS) has markedly improved over the last three decades. However, there are few data on treatment outcomes in Korean patients.


METHODS
We performed a retrospective analysis of 77 patients with RMS diagnosed and treated at Seoul National University Children's Hospital between 1986 and 2005.


RESULTS
The overall 5-year survival and event-free survival rates for all patients were 77% and 59%, respectively. The Intergroup Rhabdomyosarcoma Study clinical grouping and initial response to treatment (20-week response) were important prognostic factors.


CONCLUSIONS
The outcome of childhood RMS was closely associated with the initial staging and the initial response to treatment. Modulating therapies according to initial responses and risk factors is critical, and new treatment strategies for high-risk patients are needed.
Park
Jeong A
JA
Department of Pediatrics and Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea.
Kim
Eun Kyung
EK
Kang
Hyoung Jin
HJ
Shin
Hee Young
HY
Kim
Il Han
IH
Ahn
Hyo Seop
HS
J Clin Oncol. 1995 Mar;13(3):610-30
7884423
J Clin Oncol. 2007 Nov 1;25(31):4909-13
17971587
J Clin Oncol. 1999 Dec;17(12):3706-19
10577842
Bone Marrow Transplant. 1997 Feb;19(3):227-31
9028550
Pediatr Blood Cancer. 2004 Jan;42(1):64-73
14752797
Br J Cancer. 1977 Jan;35(1):1-39
831755
Cancer. 2005 Apr 1;103(7):1475-83
15712283
N Engl J Med. 1991 Feb 14;324(7):461-71
1988832
Cancer. 1994 Jan 1;73(1):109-17
8275414
J Clin Oncol. 2004 Dec 1;22(23):4787-94
15570080
Cell Death Differ. 2003 Jun;10(6):729-39
12761581
Eur J Cancer. 2008 Apr;44(6):876-84
18342500
J Clin Oncol. 2004 May 15;22(10):1902-8
15143083
J Pediatr Hematol Oncol. 1995 Aug;17(3):265-9
7620926
J Clin Oncol. 2000 Nov 1;18(21):3643-50
11054437
Cancer. 1988 Jan 15;61(2):209-20
3275486
Bone Marrow Transplant. 2000 Sep;26(6):627-32
11035368
J Clin Oncol. 1999 Sep;17(9):2796-803
10561355