Antiviral therapy in children with hydroa vacciniforme.
Hydroa vacciniforme is a rare, usually quite severe, photo-dermatosis. Association with Epstein-Barr virus infection and a possibly increased risk of lymphoproliferative malignancy have been demonstrated. We describe here four patients with Epstein-Barr virus-associated hydroa vacciniforme treated with acyclovir/valacyclovir therapy with a good clinical response. The children were reported to have less fatigue, fewer eruptions, less scarring, and increased ability to spend time outdoors without provoking new eruptions. This was also in agreement with clinical observations. However, one patient progressed into an anaplastic lymphoma kinase-1-negative anaplastic large-cell lymphoma in the upper jaw. This was preceded by an increase in EBV viral load. Acyclovir/valacyclovir therapy is a safe treatment. Further studies are required to confirm these results.
Lysell
Josefin
J
Department of Dermatology, Karolinska University Hospital, Solna SE-171 76 Stockholm, Sweden. josefn.lysell@karolinska.se
Wiegleb Edström
Desiree
D
Linde
Annika
A
Carlsson
Göran
G
Malmros-Svennilson
Johan
J
Westermark
Anders
A
Andersson
Jan
J
Wahlgren
Carl-Fredrik
CF
D000212:Acyclovir / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D000998:Antiviral Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004279:DNA, Viral / Q000032:analysis; D004359:Drug Therapy, Combination; D020031:Epstein-Barr Virus Infections / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D004854:Herpesvirus 4, Human / Q000235:genetics; D006801:Humans; D006837:Hydroa Vacciniforme / Q000175:diagnosis / Q000188:drug therapy* / Q000821:virology*; D007571:Jaw Diseases / Q000821:virology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000821:virology; D008297:Male; D019226:Oral Ulcer / Q000821:virology; D000077483:Valacyclovir; D014633:Valine / Q000031:analogs & derivatives* / Q000627:therapeutic use
D000998:Antiviral Agents; D004279:DNA, Viral; D014633:Valine; D000077483:Valacyclovir; D000212:Acyclovir