title: Post-operative oral contraceptive use reduces the risk of ovarian endometrioma recurrence after laparoscopic excision.
abstract: BACKGROUND
  The aim of this study was to evaluate the impact of post-operative oral contraceptives (OCs) use on the rate of recurrence after laparoscopic excision of ovarian endometrioma.
  
  
  METHODS
  In May 2005, we introduced a 'post-operative OC recommendation' for patients treated with laparoscopic excision of endometrioma. That is, at the time of the operation, we provided each patient with information about OC, known and possible benefits and risks and let her decide whether to take OC. A retrospective cohort study included 87 patients who underwent a laparoscopy after May 2005. The endometrioma recurrence rate at 24 months was compared between those who used OC for the entire follow-up period OC (n = 34) and all of the others (n = 53). We also performed logistic regression analysis to identify variables associated with recurrence. A before-after study included another 224 patients who underwent a laparoscopy before May 2005 and compared the recurrence rate before and after introduction of the 'post-operative OC recommendation'.
  
  
  RESULTS
  The recurrence rate in those who used OC for the entire period was significantly lower than in the 'others' group (2.9 versus 35.8%, relative risk 0.082, 95% CI 0.012-0.58, P < 0.001). Post-operative OC was determined as an independent variable associated with lower recurrence (OR 0.054, 95% CI 0.007-0.429, P < 0.001). The overall recurrence rate in patients who underwent laparoscopy after the introduction of the 'post-operative OC recommendation' was significantly lower than that in patients who received laparoscopy before the introduction (18.6 versus 33.1%, relative risk 0.56, 95% CI 0.32-0.97, P < 0.05).
  
  
  CONCLUSIONS
  Post-operative OC use reduces the risk of ovarian endometrioma recurrence after laparoscopic excision. This information will help in appropriate planning of pre- and post-operative management.
authors.affiliation: Department of Obstetrics and Gynecology, University of Tokyo, 7-3-1 Hongo Bunkyo, Tokyo 113-8655, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Takamura
authors.forename: K
authors.initials: K
authors.lastname: Koga
authors.forename: Y
authors.initials: Y
authors.lastname: Osuga
authors.forename: Y
authors.initials: Y
authors.lastname: Takemura
authors.forename: K
authors.initials: K
authors.lastname: Hamasaki
authors.forename: Y
authors.initials: Y
authors.lastname: Hirota
authors.forename: O
authors.initials: O
authors.lastname: Yoshino
authors.forename: Y
authors.initials: Y
authors.lastname: Taketani
mesh_terms: D000328:Adult; D002985:Clinical Protocols; D003131:Combined Modality Therapy / Q000706:statistics & numerical data; D003276:Contraceptives, Oral / Q000627:therapeutic use*; D004715:Endometriosis / Q000188:drug therapy* / Q000517:prevention & control / Q000601:surgery; D005260:Female; D006801:Humans; D010535:Laparoscopy / Q000706:statistics & numerical data; D010049:Ovarian Diseases / Q000188:drug therapy* / Q000517:prevention & control / Q000601:surgery; D010052:Ovariectomy / Q000706:statistics & numerical data; D010349:Patient Compliance; D011184:Postoperative Period; D012189:Retrospective Studies; D012306:Risk; D055502:Secondary Prevention; D013223:Statistics as Topic
chemical_list: D003276:Contraceptives, Oral