Pd-catalyzed cross-coupling of functionalized organozinc reagents with thiomethyl-substituted heterocycles.
Various thiomethyl-substituted N-heterocycles (pyridines, pyrimidines, pyrazines, pyridazines, triazines, benzothiazoles, benzoxazoles, pyrazoles, benzindazoles, quinazolines, etc.) undergo smooth Pd-catalyzed cross-coupling reactions with functionalized aryl-, heteroaryl-, benzylic-, and alkylzinc reagents using Pd(OAc)(2)/S-Phos as the catalytic system mostly at 25 degrees C. No copper salt is required to perform these reactions.
Metzger
Albrecht
A
Department Chemie und Biochemie, Ludwig-Maximilians-University, Butenandtstr. 5-13, 81377, Munich, Germany.
Melzig
Laurin
L
Despotopoulou
Christina
C
Knochel
Paul
P