title: Effect of extended-release niacin on hormone-sensitive lipase and lipoprotein lipase in patients with HIV-associated lipodystrophy syndrome.
abstract: BACKGROUND
  HIV-associated lipodystrophy syndrome is strongly associated with antiretroviral treatment in patients with human immunodeficiency virus (HIV). Niacin is thought to affect hormone-sensitive lipase (HSL) and lipoprotein lipase (LPL) expression in peripheral and intra-abdominal fat (IAF).
  
  
  OBJECTIVE
  This study investigated the effect of extended-release niacin (ERN) on adipose HSL and LPL expression in patients with HIV-associated lipodystrophy syndrome.
  
  
  METHODS
  Changes in IAF and peripheral fat content and HSL and LPL expression were examined in 4 HIV-infected patients recruited from a prospective study treated with ERN. Patients underwent limited 8 slice computerized tomography abdominal scans, dual-energy X-ray absorptiometry scans, and skin punch biopsies of the mid-thigh at baseline and after 12 weeks of ERN. All subjects were on stable highly active antiretroviral therapy prior to and during the study. Changes in body habitus were self-reported.
  
  
  RESULTS
  Normalized HSL expression decreased in 3 patients and normalized LPL expression increased in all 4 patients when comparing pre- and post-ERN treated samples. All subjects showed a decrease in total cholesterol (TC) and triglyceride (TG) levels.
  
  
  CONCLUSIONS
  Preliminary analysis suggests ERN may induce changes in HSL and LPL expression. This method is a feasible approach to identify changes in adipose RNA expression involved with lipolysis.
authors.affiliation: Hawaii AIDS Clinical Research Program, University of Hawaii, Honolulu, HI, USA.
authors.forename: Dominic C
authors.initials: DC
authors.lastname: Chow
authors.forename: Anne
authors.initials: A
authors.lastname: Tasaki
authors.forename: Jill
authors.initials: J
authors.lastname: Ono
authors.forename: Bruce
authors.initials: B
authors.lastname: Shiramizu
authors.forename: Scott A
authors.initials: SA
authors.lastname: Souza
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