Paeoniae alba Radix Promotes Peripheral Nerve Regeneration.
The present study provides in vitro and in vivo evaluation of Paeoniae alba Radix (PR) on peripheral nerve regeneration. In the in vitro study, we found the PR caused a marked enhancement of the nerve growth factor-mediated neurite outgrowth from PC12 cells as well as their expression of growth associated protein 43 and synapsin I. In the in vivo study, silicone rubber chambers filled with the PR water extract were used to bridge a 10-mm sciatic nerve defect in rats. At the conclusion of 8 weeks, regenerated nerves in the PR groups, especially at 1.25 mg ml(-1) had a higher rate of successful regeneration across the wide gap, relatively larger mean values of total nerve area, myelinated axon count and blood vessel number, and a significantly larger nerve conductive velocity compared to the control group (P  <  .05). These results suggest that the PR extract can be a potential nerve growth-promoting factor, being salutary in aiding the growth of injured peripheral nerve.
Huang
Kun-Shan
KS
Graduate Institute of Chinese Medical Science, China Medical University, Taiwan.
Lin
Jaung-Geng
JG
Lee
Han-Chung
HC
Tsai
Fuu-Jen
FJ
Bau
Da-Tian
DT
Huang
Chih-Yang
CY
Yao
Chun-Hsu
CH
Chen
Yueh-Sheng
YS
J Neurosci. 1987 May;7(5):1300-6
3033168
Restor Neurol Neurosci. 2002;20(5):169-79
12515893
Brain Res. 2002 Sep 13;949(1-2):202-8
12213317
Biomaterials. 2004 Feb;25(3):509-14
14585700
J Neurosci. 2004 Feb 11;24(6):1521-9
14960625
J Hand Surg Br. 1994 Jun;19(3):273-6
8077807
Br J Pharmacol. 2006 Jun;148(3):314-25
16582933
Eur J Neurosci. 2002 Feb;15(4):589-601
11886440
Eur J Neurosci. 2002 Feb;15(4):613-26
11886442
Ann Neurol. 2001 Oct;50(4):434-42
11601494
Int J Artif Organs. 2002 Nov;25(11):1103-8
12487399
Chem Pharm Bull (Tokyo). 2005 Jun;53(6):677-83
15930782
Evid Based Complement Alternat Med. 2009 Sep;6(3):325-30
18955245
Proc Natl Acad Sci U S A. 1976 Jul;73(7):2424-8
1065897
J Neurosci. 1987 May;7(5):1294-9
3106589
Evid Based Complement Alternat Med. 2006 Sep;3(3):349-57
16951719
J Neurosci Res. 2004 Jul 15;77(2):229-39
15211589
Br J Pharmacol. 2005 Oct;146(4):604-11
16086036
Electromyogr Clin Neurophysiol. 1998 Jul-Aug;38(5):301-4
9741008