title: Structure, function and regulation of the conserved serine proteases DegP and DegS of Escherichia coli.
abstract: Two members of the widely conserved HtrA family of serine proteases, DegP and DegS, are key players in extracytoplasmic protein quality control. The underlying mechanisms of their main functions in stress sensing, regulation and protection during the unfolded protein response are discussed.
authors.affiliation: Centre for Medical Biotechnology, FB Biology and Geography, University Duisburg-Essen, Unistr. 2, 45117 Essen, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Meltzer
authors.forename: Sonja
authors.initials: S
authors.lastname: Hasenbein
authors.forename: Nicolette
authors.initials: N
authors.lastname: Mamant
authors.forename: Melisa
authors.initials: M
authors.lastname: Merdanovic
authors.forename: Simon
authors.initials: S
authors.lastname: Poepsel
authors.forename: Patrick
authors.initials: P
authors.lastname: Hauske
authors.forename: Markus
authors.initials: M
authors.lastname: Kaiser
authors.forename: Robert
authors.initials: R
authors.lastname: Huber
authors.forename: Tobias
authors.initials: T
authors.lastname: Krojer
authors.forename: Tim
authors.initials: T
authors.lastname: Clausen
authors.forename: Michael
authors.initials: M
authors.lastname: Ehrmann
mesh_terms: D004926:Escherichia coli / Q000201:enzymology* / Q000235:genetics; D029968:Escherichia coli Proteins / Q000737:chemistry* / Q000378:metabolism*; D015964:Gene Expression Regulation, Bacterial; D006360:Heat-Shock Proteins / Q000737:chemistry* / Q000378:metabolism*; D033903:Periplasmic Proteins / Q000737:chemistry* / Q000378:metabolism*; D012697:Serine Endopeptidases / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D029968:Escherichia coli Proteins; D006360:Heat-Shock Proteins; D033903:Periplasmic Proteins; C489349:degS protein, Escherichia coli; C061682:DegP protease; D012697:Serine Endopeptidases