title: Experimental and clinical pharmacokinetics of amitryptiline: comparative analysis.
abstract: Pharmacokinetics of two amitriptyline tablets, Amitryptiline Nycomed and Amitryptiline, was investigated clinically and experimentally after a single oral dose of 50 mg. A statistically significant correlation between amitryptiline serum concentrations in dogs and healthy humans (r=0.683, p<0.006) was established. In humans, standartized values of peak concentration and area under the concentration curve were significantly higher, specific volume of distribution and total clearance were lower, and half-life and mean retention time were significantly higher than in dogs. Characteristics of apparent bioavailability in dogs and healthy people did not statistically differ.
authors.affiliation: Department of Clinical Pharmacology and Propedeutics of Internal Disease, I.M. Sechenov Moscow Medical Academy, Moscow.
authors.forename: V G
authors.initials: VG
authors.lastname: Kukes
authors.forename: S N
authors.initials: SN
authors.lastname: Kondratenko
authors.forename: M I
authors.initials: MI
authors.lastname: Savelyeva
authors.forename: A K
authors.initials: AK
authors.lastname: Starodubtsev
authors.forename: E T
authors.initials: ET
authors.lastname: Gneushev
mesh_terms: D000328:Adult; D000639:Amitriptyline / Q000097:blood* / Q000493:pharmacokinetics*; D000818:Animals; D000928:Antidepressive Agents / Q000097:blood* / Q000493:pharmacokinetics*; D019540:Area Under Curve; D004285:Dogs; D005260:Female; D006207:Half-Life; D006801:Humans; D016014:Linear Models; D008297:Male; D013045:Species Specificity; D055815:Young Adult
chemical_list: D000928:Antidepressive Agents; D000639:Amitriptyline