Early enteral feeding in conservatively managed stage II necrotizing enterocolitis is associated with a reduced risk of catheter-related sepsis.
OBJECTIVE
To compare the effect of fasting period duration on complication rates in neonates managed conservatively for necrotizing enterocolitis (NEC) Bell stage II.


METHODS
We conducted a multicenter study to analyze retrospectively multiple data collected by standardized questionnaire on all admissions for NEC between January 2000 and December 2006. NEC was staged using modified Bell criteria. We divided the conservatively managed neonates with NEC Bell stage II into two groups (those fasted for <5 days and those fasted for >5 days) and compared the complication rates.


RESULTS
Of the 47 conservatively managed neonates Bell stage II, 30 (64%) fasted for <5 days (range 1-4 days) and 17 (36%) for >5 days (range 6-16 days). There were no significant differences for any of the patient characteristics analyzed. One (3%) and four (24%) neonates, respectively, developed post-NEC bowel stricture. One (3%) and two neonates (12%) suffered NEC relapse. None and five (29%) neonates developed catheter-related sepsis.


CONCLUSIONS
Shorter fasting after NEC appears to lower morbidity after the acute phase of the disease. In particular, shorter-fasted neonates have significantly less catheter-related sepsis. We found no benefit in longer fasting.
Brotschi
Barbara
B
Department of Intensive Care and Neonatology, University Children's Hospital, Zurich, Switzerland.
Baenziger
Oskar
O
Frey
Bernhard
B
Bucher
Hans Ulrich
HU
Ersch
Jörg
J
D055499:Catheter-Related Infections / Q000517:prevention & control*; D004750:Enteral Nutrition; D020345:Enterocolitis, Necrotizing / Q000145:classification / Q000150:complications / Q000628:therapy*; D005215:Fasting / Q000009:adverse effects; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007415:Intestinal Obstruction / Q000209:etiology / Q000517:prevention & control; D008297:Male; D011247:Pregnancy; D012008:Recurrence; D012189:Retrospective Studies; D011795:Surveys and Questionnaires; D013557:Switzerland; D013997:Time Factors