title: Acral peeling skin syndrome: a case of two brothers.
abstract: We report two brothers of Middle Eastern descent with consanguineous parents who present with numerous fragile, flaccid blisters on the hands and feet. In addition to spontaneous peeling, they can manually peel skin from acral areas without pain. The symptoms worsen with warm temperatures, excessive water exposure, and perspiration. Two biopsies from flaccid blisters on the feet were taken from the older brother, which revealed cleavage at the level of the stratum corneum. A diagnosis of acral peeling skin syndrome was made.
authors.affiliation: Wayne State University, School of Medicine, Detroit, MI 48202, USA.
authors.forename: Oojwala
authors.initials: O
authors.lastname: Wakade
authors.forename: Beth
authors.initials: B
authors.lastname: Adams
authors.forename: Tor
authors.initials: T
authors.lastname: Shwayder
mesh_terms: D000293:Adolescent; D002648:Child; D005533:Foot Dermatoses / Q000235:genetics* / Q000473:pathology; D006229:Hand Dermatoses / Q000235:genetics* / Q000473:pathology; D006801:Humans; D008297:Male; D012867:Skin / Q000473:pathology; D012871:Skin Diseases / Q000235:genetics* / Q000473:pathology