title: Biocatalytic production of acyclic bis[bibenzyls] from dihydroresveratrol by crude Momordica charantia peroxidase.
abstract: Biotransformation of dihydroresveratrol by crude Momordica charantia peroxidase provided six new acyclic bis[bibenzyls] 1-6. Their structures were established on the basis of NMR and MS analyses as C-C, C-O-C, and C-CH(2)-C dimers of dihydroresveratrol. Compounds 1-6 were tested for antiproliferative activity against human prostate cancer PC3 cell line in vitro, and 2 and 6 were found to be more potent than the parent compound.
authors.affiliation: School of Pharmaceutical Sciences, Shandong University, Jinan, PR China.
authors.forename: Chun-Feng
authors.initials: CF
authors.lastname: Xie
authors.forename: Hui-Qing
authors.initials: HQ
authors.lastname: Yuan
authors.forename: Jian-Bo
authors.initials: JB
authors.lastname: Qu
authors.forename: Jie
authors.initials: J
authors.lastname: Xing
authors.forename: Bei-Bei
authors.initials: BB
authors.lastname: Lü
authors.forename: Xiao-Ning
authors.initials: XN
authors.lastname: Wang
authors.forename: Mei
authors.initials: M
authors.lastname: Ji
authors.forename: Hong-Xiang
authors.initials: HX
authors.lastname: Lou
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000096:biosynthesis / Q000627:therapeutic use; D001632:Bibenzyls / Q000378:metabolism* / Q000627:therapeutic use; D055162:Biocatalysis; D001711:Biotransformation; D045744:Cell Line, Tumor; D002851:Chromatography, High Pressure Liquid; D019281:Dimerization; D006801:Humans; D008297:Male; D029777:Momordica charantia / Q000201:enzymology*; D010544:Peroxidases / Q000378:metabolism*; D011471:Prostatic Neoplasms / Q000188:drug therapy; D021241:Spectrometry, Mass, Electrospray Ionization; D013267:Stilbenes / Q000378:metabolism*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D001632:Bibenzyls; D013267:Stilbenes; C544754:dihydroresveratrol; D010544:Peroxidases