title: The role of tissue factor and tissue factor pathway inhibitor in health and disease states.
abstract: OBJECTIVE
  To review the veterinary and human literature on the role of tissue factor (TF) and tissue factor pathway inhibitor (TFPI) in health and disease states.
  
  
  METHODS
  Original research articles and scientific reviews from both human and veterinary literature were searched for relevance to TF and TFPI.
  
  
  RESULTS
  Interest in both TF and TFPI has grown widely over the last several years. The impact TF plays in coagulation, inflammation, angiogenesis, tumor metastasis, and cellular signaling has become apparent. Treatment with TFPI for severe sepsis has been examined and is still currently under investigation. Inhibition of the TF pathway is being studied as an aid in the treatment of neoplasia. The important physiologic and pathophysiologic role these molecules play has only begun to be understood.
  
  
  RESULTS
  There is a paucity of publications that discuss the importance of TF and TFPI in veterinary medicine. An enhanced understanding of the TF pathway in human medicine, in experimental animal models treating sepsis with TFPI, and in animal models demonstrating the proangiogenic properties of TF provides relevance to veterinary medicine.
  
  
  CONCLUSIONS
  It is apparent that TF and TFPI are important in health and disease. An enhanced understanding of the physiologic and pathophysiologic roles of these factors provides better insight into coagulation, inflammation, angiogenesis, disseminated intravascular coagulation, and tumor metastasis. This greater understanding may provide for the development of therapeutics for sepsis, disseminated intravascular coagulation, and neoplasia.
authors.affiliation: Animal Emergency and Referral Hospital, Pittston, PA, USA. loudel@epix.net
authors.forename: Louis A
authors.initials: LA
authors.lastname: DelGiudice
authors.forename: George A
authors.initials: GA
authors.lastname: White
mesh_terms: D000818:Animals; D001777:Blood Coagulation / Q000502:physiology*; D001778:Blood Coagulation Disorders / Q000378:metabolism / Q000662:veterinary*; D006801:Humans; D008074:Lipoproteins / Q000378:metabolism; D013925:Thromboplastin / Q000037:antagonists & inhibitors* / Q000378:metabolism*
chemical_list: D008074:Lipoproteins; C051928:lipoprotein-associated coagulation inhibitor; D013925:Thromboplastin