The left ventral occipito-temporal response to words depends on language lateralization but not on visual familiarity.
The sensitivity of the left ventral occipito-temporal (vOT) cortex to visual word processing has triggered a considerable debate about the role of this region in reading. One popular view is that the left vOT underlies the perceptual expertise needed for rapid skilled reading. Because skilled reading breaks down when words are presented in a visually unfamiliar format, we tested this hypothesis by analyzing vOT responses to horizontally presented words (familiar format) and vertically presented words (unfamiliar format). In addition, we compared the activity in participants with left and right cerebral dominance for language generation. Our results revealed 1) that the vOT activity during reading is lateralized to the same side as the inferior frontal activity during word generation, 2) that vertically and horizontally presented words triggered the same amount of activity in the vOT of the dominant hemisphere, but 3) that there was significantly more activity for vertically presented words in the vOT of the nondominant hemisphere. We suggest that the reading-related activity in vOT reflects the integration of general perceptual processes with language processing in the anterior brain regions and is not limited to skilled reading in the familiar horizontal format.
Cai
Qing
Q
Laboratory of Language, Brain and Cognition (L2C2), CNRS-University of Lyon UMR 5230, 69675 Bron, France. qing.cai@isc.cnrs.fr
Paulignan
Yves
Y
Brysbaert
Marc
M
Ibarrola
Danielle
D
Nazir
Tatjana A
TA
D000328:Adult; D000704:Analysis of Variance; D001931:Brain Mapping; D003657:Decision Making / Q000502:physiology; D004569:Electroencephalography / Q000379:methods; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D007802:Language; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009778:Occipital Lobe / Q000098:blood supply / Q000502:physiology*; D010100:Oxygen / Q000097:blood; D010775:Photic Stimulation / Q000379:methods; D011932:Reading; D021641:Recognition, Psychology / Q000502:physiology*; D013702:Temporal Lobe / Q000098:blood supply / Q000502:physiology*; D014825:Vocabulary; D055815:Young Adult
D010100:Oxygen