title: SKP2A protein, an F-box that regulates cell division, is degraded via the ubiquitin pathway.
abstract: The ubiquitin pathway is emerging as a powerful system that controls the stability of key regulatory proteins. In plants, this pathway plays an important role in controlling several developmental processes, responses to environmental changes and also cell division. Arabidopsis SKP2A is an F-box protein that regulates the stability of the E2FC-DPB transcription factor, a repressor of cell proliferation. Although the function of SKP2A is to recruit targets for degradation, we have shown that SKP2A is also degraded through the Ub/26S pathway and, interestingly, auxin stimulates such degradation. Overexpression of SKP2A positively regulates cell division, increasing the number of cells in G(2)/M, reducing the level of ploidy and developing higher number of lateral root primordia. In addition, we showed in this report that overexpression of SKP2A increased the survival of Arabidopsis plants when they grown on a medium with high levels of sucrose, likely by maintaining cell division active. Thus, it is likely that SKP2A connects cell division with stress responses.
authors.affiliation: Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria; Department Biotecnología (INIA); Madrid, Spain;
authors.forename: Silvia
authors.initials: S
authors.lastname: Jurado
authors.forename: Sara Díaz
authors.initials: SD
authors.lastname: Triviño
authors.forename: Zamira
authors.initials: Z
authors.lastname: Abraham
authors.forename: Concepción
authors.initials: C
authors.lastname: Manzano
authors.forename: Crisanto
authors.initials: C
authors.lastname: Gutierrez
authors.forename: Carlos
authors.initials: C
authors.lastname: Del Pozo
references.citation: Curr Opin Plant Biol. 2007 Dec;10(6):624-32
references.pmid: 17851112
references.citation: Ann Bot. 2007 May;99(5):787-822
references.pmid: 17220175
references.citation: Curr Opin Plant Biol. 2006 Dec;9(6):631-8
references.pmid: 17005440
references.citation: Plant J. 2008 Mar;53(5):828-41
references.pmid: 18036202
references.citation: Annu Rev Plant Biol. 2004;55:555-90
references.pmid: 15377232
references.citation: Plant Cell. 2006 Sep;18(9):2224-35
references.pmid: 16920782
references.citation: Plant Cell. 2002 Feb;14(2):421-33
references.pmid: 11884684
references.citation: Physiol Rev. 2002 Apr;82(2):373-428
references.pmid: 11917093
references.citation: PLoS One. 2007 Aug 08;2(8):e718
references.pmid: 17684564
references.citation: Curr Opin Plant Biol. 2005 Feb;8(1):93-102
references.pmid: 15653406
references.citation: Nature. 2005 May 26;435(7041):441-5
references.pmid: 15917797
references.citation: Plant Physiol. 2007 Apr;143(4):1467-83
references.pmid: 17293439
references.citation: Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):11519-24
references.pmid: 12169662
references.citation: Plant J. 2008 Mar;53(5):705-16
references.pmid: 18005227
references.citation: Plant Cell. 2002 Dec;14(12):3057-71
references.pmid: 12468727
references.citation: Plant J. 2003 Jun;34(6):753-67
references.pmid: 12795696
references.citation: Plant Cell. 2004 Dec;16(12):3181-95
references.pmid: 15579807
references.citation: Nature. 2007 Apr 5;446(7136):640-5
references.pmid: 17410169