title: New secoisolariciresinol derivatives from Lindera obtusiloba stems and their neuroprotective activities.
abstract: A methanolic extract of Lindera obtusiloba (Lauraceae) stems significantly attenuated glutamate-induced oxidative stress in HT22 hippocampal cells. Two new secoisolariciresinol derivatives, characterized as 9,9'- O-di-(E)-feruloyl-meso-5,5'-dimethoxysecoisolariciresinol (1) and 9,9'-O-di-(E)-sinapinoyl-meso-5,5'-dimethoxysecoisolariciresinol (2), were isolated, along with the known compound 9,9'-O-di-(E)-feruloyl-meso-secoisolariciresinol (3), from the methanolic extract of L. obtusiloba stems. Compounds 1, 2, and 3 showed neuroprotective effects on glutamate-induced toxicity in HT22 cells.
authors.affiliation: College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Seoul, Republic of Korea.
authors.forename: Ki Yong
authors.initials: KY
authors.lastname: Lee
authors.forename: Soon-Han
authors.initials: SH
authors.lastname: Kim
authors.forename: Eun Ju
authors.initials: EJ
authors.lastname: Jeong
authors.forename: Jung Hyun
authors.initials: JH
authors.lastname: Park
authors.forename: Seung Hyun
authors.initials: SH
authors.lastname: Kim
authors.forename: Young Choong
authors.initials: YC
authors.lastname: Kim
authors.forename: Sang Hyun
authors.initials: SH
authors.lastname: Sung
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002460:Cell Line; D018698:Glutamic Acid / Q000633:toxicity; D006624:Hippocampus; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D027443:Lindera / Q000737:chemistry*; D051379:Mice; D015394:Molecular Structure; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism; D018696:Neuroprotective Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018547:Plant Stems
chemical_list: C549781:9,9'- O-di-(E)-feruloyl-meso-5,5'-dimethoxysecoisolariciresinol; C549782:9,9'-O-di-(E)-sinapinoyl-meso-5,5'-dimethoxysecoisolariciresinol; D000975:Antioxidants; D017705:Lignans; D018696:Neuroprotective Agents; D010936:Plant Extracts; D018698:Glutamic Acid