title: Opportunity for catch-up HPV vaccination in young women after first delivery.
abstract: BACKGROUND
  Early age at first delivery has been identified as a risk factor for high-risk HPV-type infection and cervical cancer development.
  
  
  METHODS
  A cross-sectional study was carried out in a large public maternity hospital in São Paulo, Brazil. During June 2006 to February 2007, 301 women aged 15-24 years who gave birth to their first child were recruited between 43 and 60 days after delivery. Detection of HPV DNA in cervical specimens was performed using a standardised PCR protocol with PGMY09/11 primers. The association of selected factors with HPV infection was assessed by using a Generalised Linear Model.
  
  
  RESULTS
  HPV DNA was detected in 58.5% (95% CI 52.7% to 64.0%) of the enrolled young women. The most common types of HPV found were: HPV16, HPV51, HPV52, HPV58 and HPV71. The overall prevalence of HPV types targeted by the HPV prophylactic vaccines was: HPV 16-12.0%, HPV 18- 2.3% and HPV 6 and 11 4.3%. In the multivariate analysis, only age (inversely, p for trend=0.02) and smoking habits were independently associated with HPV infection.
  
  
  CONCLUSIONS
  The findings show that these young primiparous women had high cervical HPV prevalence, suggesting that this is a high-risk group for cervical cancer development. Nevertheless, 17.3% were positive for any of the four HPV types included in HPV vaccines (HPV6, 11, 16 or 18), with 13.3% positive for HPV 16 or 18 and only 1.0% having both vaccine related-oncogenic HPV types. Thus, young primiparous women could benefit from catch-up HPV vaccination programmes.
authors.affiliation: Hospital Maternidade Leonor Mendes de Barros, Av Celso Garcia, 2477, 03015-000 Belenzinho São Paulo-SP, Brazil. crisrama@usp.br
authors.forename: Cristina Helena
authors.initials: CH
authors.lastname: Rama
authors.forename: Luisa L
authors.initials: LL
authors.lastname: Villa
authors.forename: Sonia
authors.initials: S
authors.lastname: Pagliusi
authors.forename: Maria A
authors.initials: MA
authors.lastname: Andreoli
authors.forename: Maria C
authors.initials: MC
authors.lastname: Costa
authors.forename: Patricia
authors.initials: P
authors.lastname: Thomann
authors.forename: Venancio A F
authors.initials: VA
authors.lastname: Alves
authors.forename: Adhemar
authors.initials: A
authors.lastname: Longatto-Filho
authors.forename: Jose
authors.initials: J
authors.lastname: Eluf-Neto
mesh_terms: D000293:Adolescent; D000328:Adult; D052685:Alphapapillomavirus / Q000235:genetics; D001938:Brazil; D003430:Cross-Sectional Studies; D004279:DNA, Viral / Q000235:genetics; D005260:Female; D006801:Humans; D008423:Maternal Age; D030361:Papillomavirus Infections / Q000453:epidemiology / Q000517:prevention & control* / Q000821:virology; D053918:Papillomavirus Vaccines / Q000008:administration & dosage*; D010298:Parity; D049590:Postpartum Period; D011203:Poverty; D011247:Pregnancy; D015995:Prevalence; D012307:Risk Factors; D013997:Time Factors; D014626:Vaginal Smears; D055815:Young Adult
chemical_list: D004279:DNA, Viral; D053918:Papillomavirus Vaccines