Challenges in cardiac tissue engineering.
Cardiac tissue engineering aims to create functional tissue constructs that can reestablish the structure and function of injured myocardium. Engineered constructs can also serve as high-fidelity models for studies of cardiac development and disease. In a general case, the biological potential of the cell-the actual "tissue engineer"-is mobilized by providing highly controllable three-dimensional environments that can mediate cell differentiation and functional assembly. For cardiac regeneration, some of the key requirements that need to be met are the selection of a human cell source, establishment of cardiac tissue matrix, electromechanical cell coupling, robust and stable contractile function, and functional vascularization. We review here the potential and challenges of cardiac tissue engineering for developing therapies that could prevent or reverse heart failure.
Vunjak-Novakovic
Gordana
G
Department of Biomedical Engineering, Columbia University, New York, New York 10032, USA.
Tandon
Nina
N
Godier
Amandine
A
Maidhof
Robert
R
Marsano
Anna
A
Martens
Timothy P
TP
Radisic
Milica
M
D000818:Animals; D004558:Electric Stimulation / Q000379:methods; D006321:Heart / Q000502:physiology*; D016027:Heart Transplantation / Q000379:methods / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D009206:Myocardium / Q000166:cytology; D009924:Organ Culture Techniques; D010477:Perfusion / Q000379:methods; D023822:Tissue Engineering / Q000379:methods* / Q000592:standards
Am J Physiol. 1986 Mar;250(3 Pt 2):H453-63
3953838
Anat Rec A Discov Mol Cell Evol Biol. 2003 Feb;270(2):109-16
12524686
Proc Natl Acad Sci U S A. 2009 Jun 2;106(22):8918-22
19458047
Nat Clin Pract Cardiovasc Med. 2006 Mar;3 Suppl 1:S57-64
16501633
Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7808-11
12805561
Nat Med. 1999 Apr;5(4):434-8
10202935
Nature. 2008 May 22;453(7194):524-8
18432194
Circulation. 2008 Jul 29;118(5):498-506
18625891
Nat Biotechnol. 2005 Jul;23(7):845-56
16003373
Cell. 2008 Feb 22;132(4):598-611
18295578
Coron Artery Dis. 2005 Mar;16(2):105-10
15735403
Semin Cell Dev Biol. 2007 Feb;18(1):153-60
17321172
Int J Biochem Cell Biol. 2005 Apr;37(4):715-9
15694831
Science. 1997 Feb 14;275(5302):964-7
9020076
Circulation. 2006 Jul 4;114(1 Suppl):I72-8
16820649
Nature. 2001 Apr 5;410(6829):701-5
11287958
Tissue Eng. 2002 Apr;8(2):175-88
12031108
Circ Res. 1974 Aug;35(2):suppl II:17-26
4276486
Nat Clin Pract Cardiovasc Med. 2008 Aug;5 Suppl 2:S96-102
18641613
Am J Physiol Heart Circ Physiol. 2005 Mar;288(3):H1278-89
15539422
J Membr Biol. 1979 Dec 12;51(1):75-96
522130
Circulation. 2007 Feb 20;115(7):896-908
17283259
Nature. 2007 Dec 6;450(7171):819-24
18064002
Biotechnol Prog. 2008 Jul-Aug;24(4):907-20
19194900
Nature. 2004 Apr 8;428(6983):668-73
15034594
Circ Res. 2005 Dec 9;97(12):1220-31
16339494
Nature. 2008 May 15;453(7193):345-51
18480816
Circulation. 1992 Jul;86(1):38-46
1535573
Nat Clin Pract Cardiovasc Med. 2006 Mar;3 Suppl 1:S23-8
16501626
Blood. 2003 Aug 15;102(4):1548-9
12900350
Cardiovasc Res. 2003 Mar;57(3):793-803
12618241
Biomaterials. 2003 Dec;24(27):5009-14
14559014
Nat Biotechnol. 2008 Jan;26(1):101-6
18059259
Tissue Eng Part A. 2009 Apr;15(4):851-60
18847360
Biomaterials. 2007 Jun;28(17):2706-17
17346788
Transfusion. 2000 Jan;40(1):35-43
10644809
Genes Dev. 2005 Aug 1;19(15):1787-98
16077007
Circulation. 2002 Sep 24;106(12 Suppl 1):I151-7
12354725
Nat Med. 2006 Apr;12(4):452-8
16582915
Tissue Eng Part A. 2009 Feb;15(2):205-19
18694293
Acta Biomater. 2008 May;4(3):477-89
18328795
Nature. 2008 May 15;453(7193):302-5
18480810
FASEB J. 1997 Jul;11(8):683-94
9240969
Bioessays. 2000 Feb;22(2):188-99
10655038
Science. 1995 Jan 6;267(5194):104-8
7528940
Nat Med. 2008 Feb;14(2):213-21
18193059
Circ Res. 2007 May 11;100(9):1249-60
17495232
Nature. 2006 Jun 29;441(7097):1075-9
16810242
Circulation. 2005 Jan 18;111(2):150-6
15642764
Nat Med. 2001 Apr;7(4):430-6
11283669
Adv Drug Deliv Rev. 2008 Jan 14;60(2):199-214
18006108
J Cell Sci. 2008 Feb 1;121(Pt 3):255-64
18216330
Circ Res. 2002 Feb 22;90(3):e40
11861428
J Clin Invest. 1999 Mar;103(5):697-705
10074487
Development. 2008 Jan;135(2):193-205
18156162
Nat Mater. 2008 Aug;7(8):617-8
18654587
Am J Physiol Heart Circ Physiol. 2006 Sep;291(3):H1015-26
16617141
Nat Photonics. 2007;1(9):526-530
18974848
Biomaterials. 2008 Apr;29(11):1610-9
18194813
Circ Res. 2008 May 9;102(9):1008-10
18436793
Tissue Eng. 2005 Jul-Aug;11(7-8):1122-32
16144448
Basic Res Cardiol. 2005 Jul;100(4):337-45
15822004
Plast Reconstr Surg. 1998 May;101(6):1552-60
9583486
Circulation. 2004 Dec 21;110(25):3803-7
15596566
J Orthop Res. 2007 Aug;25(8):1018-28
17457824
Am J Physiol. 1999 Aug;277(2):H433-44
10444466
Nature. 2005 Feb 10;433(7026):647-53
15703750
Proc Natl Acad Sci U S A. 2003 May 13;100(10):5807-12
12716973
Nat Protoc. 2008;3(4):719-38
18388955
Adv Drug Deliv Rev. 2008 Jan 14;60(2):215-28
17997187
Nat Biotechnol. 2002 Jun;20(6):602-6
12042865
Tissue Eng. 2006 Aug;12(8):2077-91
16968150
J Biol Chem. 1990 Mar 5;265(7):3595-8
2105950
J Biomed Mater Res A. 2008 Sep;86(3):713-24
18041719
Circulation. 2007 Jan 23;115(3):353-60
17200440
Biotechnol Bioeng. 2007 Dec 15;98(6):1195-208
17614333
Cell. 2006 Aug 25;126(4):677-89
16923388
Nature. 2008 Feb 21;451(7181):937-42
18288183
Circ Res. 2006 Jan 6;98(1):25-35
16397155
Curr Opin Mol Ther. 2005 Aug;7(4):293-9
16121694
Circulation. 2005 Sep 20;112(12):1748-55
16172284
Circ Res. 2004 Feb 6;94(2):223-9
14656930
Blood. 2005 Feb 15;105(4):1815-22
15494428
Nat Protoc. 2009;4(2):155-73
19180087
Biotechnol Bioeng. 2003 May 20;82(4):403-14
12632397
Nature. 2008 May 15;453(7193):322-9
18480813
Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11474-9
16061805
Nat Clin Pract Cardiovasc Med. 2006 Mar;3 Suppl 1:S18-22
16501624
Tissue Eng. 2007 Sep;13(9):2185-93
17518740
Differentiation. 2008 Dec;76(10):1044-56
18637024
Nat Clin Pract Cardiovasc Med. 2006 Mar;3 Suppl 1:S46-51
16501631
Biotechnol Bioeng. 1999 Sep 5;64(5):580-9
10404238
Biomaterials. 2007 Oct;28(29):4277-93
17604100
N Engl J Med. 2006 Sep 21;355(12):1210-21
16990384
Biotechnol Bioeng. 2006 Feb 5;93(2):332-43
16270298
N Engl J Med. 2006 Sep 21;355(12):1222-32
16990385
Nat Med. 2003 Sep;9(9):1195-201
12910262
Adv Drug Deliv Rev. 2008 Jan 14;60(2):277-85
18006178
Circ Res. 2002 Feb 8;90(2):223-30
11834716
Am J Physiol Heart Circ Physiol. 2004 Feb;286(2):H507-16
14551059
Lancet. 2006 Jan 14;367(9505):113-21
16413875
FASEB J. 2000 Apr;14(5):669-79
10744624
Nat Biotechnol. 2007 Sep;25(9):1015-24
17721512
Biochem Biophys Res Commun. 2007 Oct 5;361(4):847-53
17689494
Annu Rev Physiol. 1997;59:551-71
9074777
Proc Natl Acad Sci U S A. 2004 Dec 28;101(52):18129-34
15604141
Cell. 2008 Sep 5;134(5):877-86
18691744
Anal Biochem. 1985 Mar;145(2):302-7
4014661
Circulation. 2004 Aug 24;110(8):962-8
15302801
Circ Res. 2004 Jul 9;95(1):9-20
15242981
Nat Med. 2007 Aug;13(8):901-2
17679999
Circ Res. 2007 Feb 2;100(2):263-72
17218605
Birth Defects Res C Embryo Today. 2008 Dec;84(4):335-47
19067427
Am J Physiol. 1996 May;270(5 Pt 1):C1284-92
8967427
Circ Res. 2006 Mar 17;98(5):573-5
16543504
Cell. 2003 Sep 19;114(6):763-76
14505575
N Engl J Med. 2006 Sep 21;355(12):1199-209
16990383
Stem Cell Rev. 2006;2(3):185-201
17625255
FASEB J. 2007 May;21(7):1345-57
17284483
Nano Lett. 2007 Oct;7(10):3071-9
17887799
FASEB J. 2006 Apr;20(6):708-10
16439619
Tissue Eng. 2006 Dec;12(12):3285-305
17518670
Blood. 2005 Apr 1;105(7):2631-9
15585658
Bioprocess Biosyst Eng. 2008 Aug;31(5):393-400
18026758
Tissue Eng. 2006 Oct;12(10):2843-52
17518653