title: Antinociceptive and anti-inflammatory activities of iridoid glycosides extract of Lamiophlomis rotata (Benth.) Kudo.
abstract: Lamiophlomis rotata (Benth.) Kudo is a perennial herb (Labiatae) used as the Tibetan traditional medicine with the effects of alleviating pain, detumescence, hemostasis, promoting blood circulation to remove blood stasis and reinforcing marrow. In this study, we investigated the antinociceptive and anti-inflammatory activities of iridoid glycosides extract of L. rotata (IGLR) in mice. Our results showed that the iridoid glycosides extract could decrease acetic-acid-induced writhings times and formalin-induced lickings times, inhibit carrageenan-induced hind paw edema and xylene-induced ear swelling, and suppress peritoneal capillary permeability and leukocyte infiltration also induced by acetic acid in mice. All of these results suggested that the iridoid glycosides extract possesses the significant antinociceptive and anti-inflammatory activities.
authors.affiliation: Department of Pharmacy, Lanzhou General Hospital of PLA, Lanzhou, PR China. limaox2005@yahoo.com.cn
authors.forename: Maoxing
authors.initials: M
authors.lastname: Li
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Shang
authors.forename: Ruxue
authors.initials: R
authors.lastname: Zhang
authors.forename: Zhengping
authors.initials: Z
authors.lastname: Jia
authors.forename: Pengcheng
authors.initials: P
authors.lastname: Fan
authors.forename: Qiang
authors.initials: Q
authors.lastname: Ying
authors.forename: Lili
authors.initials: L
authors.lastname: Wei
mesh_terms: D019342:Acetic Acid; D000700:Analgesics / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001522:Behavior, Animal / Q000187:drug effects; D002199:Capillary Permeability / Q000187:drug effects; D004427:Ear Diseases / Q000139:chemically induced / Q000188:drug therapy; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D005557:Formaldehyde; D006027:Glycosides / Q000494:pharmacology / Q000627:therapeutic use*; D039823:Iridoids / Q000494:pharmacology / Q000627:therapeutic use*; D019686:Lamiaceae / Q000737:chemistry*; D051379:Mice; D008807:Mice, Inbred BALB C; D020556:Neutrophil Infiltration / Q000187:drug effects; D010146:Pain / Q000188:drug therapy; D010529:Peritoneal Cavity; D008517:Phytotherapy; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D014992:Xylenes
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D006027:Glycosides; D039823:Iridoids; D010936:Plant Extracts; D014992:Xylenes; D005557:Formaldehyde; D019342:Acetic Acid