title: Apathy is not associated with basal ganglia atrophy in frontotemporal dementia.
abstract: OBJECTIVE
  To determine whether basal ganglia atrophy, known to be associated with apathy in nondementia populations, was associated with presence of apathy in patients with frontotemporal dementia (FTD).
  
  
  METHODS
  A cross-sectional case study was conducted at two tertiary dementia care clinics in Toronto, Ontario, Canada. Striatal and thalamic gray matter volumes and apathy measures were collected from 21 subjects with FTD, 6 of whom did not show apathy on the Neuropsychiatric Inventory.
  
  
  RESULTS
  No significant differences in gray matter volumes were found between apathetic and nonapathetic groups for the striatum or the thalamus.
  
  
  CONCLUSIONS
  Our findings imply that the etiology of apathy seen in patients with FTD differs from that of patients with apathy after acquired injuries to the basal ganglia. Further study is needed to determine whether posterior thalamic atrophy correlates with apathy in FTD or functional imaging techniques might successfully find a relationship between basal ganglia dysfunction and apathy.
authors.affiliation: Division of Neurology, Rotman Research Institute, Baycrest, Toronto, ON, Canada M6A 2E1.
authors.forename: Kira A
authors.initials: KA
authors.lastname: Links
authors.forename: Tiffany W
authors.initials: TW
authors.lastname: Chow
authors.forename: Malcolm
authors.initials: M
authors.lastname: Binns
authors.forename: Morris
authors.initials: M
authors.lastname: Freedman
authors.forename: Donald T
authors.initials: DT
authors.lastname: Stuss
authors.forename: Chris J M
authors.initials: CJ
authors.lastname: Scott
authors.forename: Joel
authors.initials: J
authors.lastname: Ramirez
authors.forename: Sandra E
authors.initials: SE
authors.lastname: Black
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001284:Atrophy / Q000473:pathology* / Q000503:physiopathology; D001479:Basal Ganglia / Q000473:pathology / Q000503:physiopathology*; D003430:Cross-Sectional Studies; D003704:Dementia / Q000473:pathology* / Q000503:physiopathology / Q000523:psychology; D003863:Depression / Q000209:etiology* / Q000473:pathology / Q000523:psychology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D009864:Ontario; D011788:Quality of Life; D011795:Surveys and Questionnaires
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