Effect of transplantation of bone marrow cells on morphology of rat myocardium after cryodestruction.
We studied the effects of bone marrow cell transplantation on myocardium of the prenecrotic zone in Wistar rats. Intramyocardial cell transplantation reduced the severity of hypertrophy of myocardium and the degree of its cicatricial degeneration on day 40 after cryodestruction. The morphology of the myocardium in the prenecrotic zone depended on the type of transplanted cells. The course of inflammation was swifter; vascularization of the myocardium was more intensive. The best effect, evaluated by the number of new vessels, was observed after MSC transplantation. Hence, the positive effect of bone marrow cell transplantation is realized at the expense of more rapid structural organization of the damaged site and stimulation of myocardial vascularization.
Afanasyev
S A
SA
Institute of Cardiology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences. lpf@cardio.tsu.ru
Rogovskaya
E V
EV
Sviridov
I N
IN
Falaleeva
L P
LP
Shakhov
V P
VP
Popov
S V
SV
Karpov
R S
RS
D000818:Animals; D001835:Body Weight; D016026:Bone Marrow Transplantation; D006348:Cardiac Surgical Procedures; D006332:Cardiomegaly / Q000473:pathology / Q000601:surgery; D003080:Cold Temperature / Q000009:adverse effects*; D006335:Heart Injuries / Q000276:immunology / Q000473:pathology* / Q000601:surgery*; D006352:Heart Ventricles / Q000276:immunology / Q000473:pathology / Q000601:surgery; D007249:Inflammation / Q000473:pathology / Q000601:surgery; D008297:Male; D009206:Myocardium / Q000276:immunology / Q000473:pathology*; D018919:Neovascularization, Physiologic; D009929:Organ Size; D051381:Rats; D017208:Rats, Wistar