sTNFR-1 is an early inflammatory marker in community versus institutionalized elderly women.
OBJECTIVE
To evaluate plasma sTNFR-1 and IL-6 levels and correlate with hand grip in the institutionalized and community living Brazilian elderly.


METHODS
A convenience sample of 110 elderly women (71.17 + or - 7.44 years) was selected. Plasma sTNFR-1 and IL-6 levels were measured by ELISA. For the measurement of hand grip, a JAMAR dynamometer was used.


RESULTS
Plasma concentrations of inflammatory markers were significantly higher in institutionalized elderly (sTNFR-1: 479 + or - 22 pg/mL; IL-6: 6.3 + or - 0.8 pg/mL) than in community-dwelling elderly (sTNFR-1: 329 + or - 24 pg/mL; IL-6: 2.5 + or - 0.4 pg/mL; P < 0.0001). Institutionalized elderly had reduced hand grip (15 + or - 0.8 Kgf) in comparison to community dwelling elderly (23 + or - 0.6 Kgf; P < 0.05). When individuals were subdivided in age groups, sTNFR-1 was higher in community dwelling versus institutionalized elderly in the 60-70 age range.


CONCLUSIONS
Our results demonstrate that being institutionalized has an impact on levels of inflammatory markers.
Coelho
Fernanda Matos
FM
Laboratório da Dor e Inflamação em Reabilitação Sala 2102-A., Departamento de Fisioterapia da Escola de Educação Física, Fisioterapia e Terapia, Ocupacional, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Av. Antonio Carlos 6627, Pampulha, 31270-901 Belo Horizonte, MG, Brazil. fematoscoelho@gmail.com
Narciso
F M S
FM
Oliveira
D M G
DM
Pereira
D S
DS
Teixeira
A L
AL
Teixeira
M M
MM
Souza
D G
DG
Pereira
L S M
LS
D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D001938:Brazil; D003430:Cross-Sectional Studies; D005260:Female; D018737:Hand Strength / Q000502:physiology; D006801:Humans; D057187:Independent Living; D007249:Inflammation / Q000097:blood*; D007326:Institutionalization; D015850:Interleukin-6 / Q000097:blood; D008875:Middle Aged; D053581:Muscle Strength Dynamometer; D047888:Receptors, Tumor Necrosis Factor, Type I / Q000097:blood*; D012111:Residence Characteristics; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
D015415:Biomarkers; D015850:Interleukin-6; D047888:Receptors, Tumor Necrosis Factor, Type I; D014409:Tumor Necrosis Factor-alpha
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