Encephalomyelitis mimicking multiple sclerosis associated with chronic graft-versus-host disease after allogeneic bone marrow transplantation.
We describe a case of encephalomyelitis mimicking multiple sclerosis associated with chronic graft-versus-host disease (GVHD) occurring after allogeneic bone marrow transplantation (BMT) for myelodysplastic syndrome. Immunosuppressive therapy, consisting of a therapeutic dose of cyclosporine A and a maintenance dose of methylprednisolone, was effective in treating symptoms. Although central nervous system GVHD is very rare and remains controversial, presentation of neurological symptoms after allogeneic BMT warrants consideration of GVHD in the differential diagnosis.
Matsuo
Yayoi
Y
Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka.
Kamezaki
Kenjiro
K
Takeishi
Shoichiro
S
Takenaka
Katsuto
K
Eto
Tetsuya
T
Nonami
Atsushi
A
Miyamoto
Toshihiro
T
Iwasaki
Hiromi
H
Harada
Naoki
N
Nagafuji
Koji
K
Teshima
Takanori
T
Akashi
Koichi
K
D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D003937:Diagnosis, Differential; D004679:Encephalomyelitis / Q000175:diagnosis* / Q000209:etiology*; D005260:Female; D006086:Graft vs Host Disease / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D009103:Multiple Sclerosis / Q000175:diagnosis / Q000209:etiology; D014184:Transplantation, Homologous / Q000009:adverse effects; D055815:Young Adult