Gemfibrozil, stretching arms beyond lipid lowering.
Gemfibrozil is long known for its ability to reduce the level of triglycerides in the blood circulation and to decrease the risk of hyperlipidemia. However, a number of recent studies reveal that apart from its lipid-lowering effects, gemfibrozil can also regulate many other signaling pathways responsible for inflammation, switching of T-helper cells, cell-to-cell contact, migration, and oxidative stress. In this review, we have made an honest attempt to analyze various biological activities of gemfibrozil and associated mechanisms that may help to consider this drug for different human disorders as primary or adjunct therapy.
Roy
Avik
A
Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA.
Pahan
Kalipada
K
D002450:Cell Communication / Q000187:drug effects* / Q000276:immunology; D002465:Cell Movement / Q000187:drug effects* / Q000276:immunology; D015248:Gemfibrozil / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000276:immunology / Q000517:prevention & control; D000960:Hypolipidemic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D007249:Inflammation / Q000097:blood / Q000276:immunology; D018384:Oxidative Stress / Q000187:drug effects* / Q000276:immunology; D015398:Signal Transduction / Q000187:drug effects* / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*; D014280:Triglycerides / Q000097:blood / Q000276:immunology
D000960:Hypolipidemic Agents; D014280:Triglycerides; D015248:Gemfibrozil
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