Regeneration of myocardium--dawn of a new era!
The notion of repairing or regenerating lost myocardium via cell based therapies is highly appealing. The identification of adult bone marrow stem cells and their supportive pre-clinical data fueled the interest in utilizing these cells for physiological relevant cardiomyogenesis. Enthusiasm for cardiac regeneration via cell therapy has further increased by many encouraging reports in both animal and human studies. Further intensive research in basic science paralleled with clinical trials may make cardiovascular regenerative medicine a reality in fighting against congestive heart failure, the leading cause of morbidity and mortality associated with loss of functional cardiomyocytes. Here we review the preclinical phase to clinical phase of stem cell therapy for myocardium and provide a brief overview on unresolved issue and mechanistic insight of the repair.
Shah
Vinod K
VK
Sir H. N. Hospital and Research Centre, Raja Rammohan Roy Road, Mumbai.
Shali
Kavita K
KK
D000818:Animals; D016026:Bone Marrow Transplantation; D009202:Cardiomyopathies / Q000628:therapy; D064987:Cell- and Tissue-Based Therapy; D006801:Humans; D032446:Myoblasts / Q000166:cytology* / Q000502:physiology; D009203:Myocardial Infarction / Q000628:therapy*; D009206:Myocardium / Q000166:cytology*; D012038:Regeneration; D044968:Regenerative Medicine; D033581:Stem Cell Transplantation