title: Metaphysical and ethical perspectives on creating animal-human chimeras.
abstract: This paper addresses several questions related to the nature, production, and use of animal-human (a-h) chimeras. At the heart of the issue is whether certain types of a-h chimeras should be brought into existence, and, if they are, how we should treat such creatures. In our current research environment, we recognize a dichotomy between research involving nonhuman animal subjects and research involving human subjects, and the classification of a research protocol into one of these categories will trigger different ethical standards as to the moral permissibility of the research in question. Are a-h chimeras entitled to the more restrictive and protective ethical standards applied to human research subjects? We elucidate an Aristotelian-Thomistic metaphysical framework in which to argue how such chimeras ought to be defined ontologically. We then examine when the creation of, and experimentation upon, certain types of a-h chimeras may be morally permissible.
authors.affiliation: Indiana University-Purdue University Indianapolis,Indianapolis, IN 46202, USA. jeberl@iupui.edu
authors.forename: Jason T
authors.initials: JT
authors.lastname: Eberl
authors.forename: Rebecca A
authors.initials: RA
authors.lastname: Ballard
mesh_terms: D032761:Animal Experimentation / Q000941:ethics; D000818:Animals; D002678:Chimera; D026689:Ethical Analysis; D032984:Ethics, Research; D005818:Genetic Engineering / Q000941:ethics*; D006801:Humans; D008678:Metaphysics; D009014:Morals; D010686:Philosophy, Medical