title: Aqueous extract of Zanthoxylum schinifolium elicits contractile and secretory responses via beta1-adrenoceptor activation in beating rabbit atria.
abstract: OBJECTIVE
  Although Zanthoxylum schinifolium has long been used in the traditional oriental medicine, cardiac effects have not well been documented. The aim of the present study was to investigate the effects of aqueous extract of leaves and stems from Zanthoxylum schinifolium (AZS) on inotropic effect and atrial natriuretic peptide (ANP) secretion.
  
  
  METHODS
  The AZS-induced changes in atrial dynamics, cAMP efflux and atrial ANP secretion were determined in isolated perfused beating rabbit atria.
  
  
  RESULTS
  AZS increased atrial pulse pressure, stroke volume, and cAMP efflux concomitantly with inhibition of ANP secretion in a concentration-dependent manner. The AZS-induced increases in atrial dynamics and cAMP efflux, and decrease in ANP secretion were attenuated by pretreatment with propranolol and CGP 20712 but not ICI 118,551. Also, the AZS-induced changes in atrial dynamics and ANP secretion were attenuated by diltiazem and KT 5720. Diltiazem and KT 5720 had not significant effect on the AZS-induced increase in cAMP efflux.
  
  
  CONCLUSIONS
  These results suggest that AZS elicits a positive inotropic effect and decrease in ANP secretion via beta(1)-adrenoceptor-cAMP-Ca(2+) signaling in beating rabbit atria.
authors.affiliation: Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan, Jeonbuk, 570-749, Republic of Korea.
authors.forename: Hao Zhen
authors.initials: HZ
authors.lastname: Cui
authors.forename: Hye Ran
authors.initials: HR
authors.lastname: Choi
authors.forename: Deok Ho
authors.initials: DH
authors.lastname: Choi
authors.forename: Kyung Woo
authors.initials: KW
authors.lastname: Cho
authors.forename: Dae Gill
authors.initials: DG
authors.lastname: Kang
authors.forename: Ho Sub
authors.initials: HS
authors.lastname: Lee
mesh_terms: D000818:Animals; D009320:Atrial Natriuretic Factor / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D002227:Carbazoles / Q000494:pharmacology; D002316:Cardiotonic Agents / Q000494:pharmacology*; D002317:Cardiovascular Agents / Q000494:pharmacology; D000242:Cyclic AMP / Q000378:metabolism*; D004110:Diltiazem / Q000494:pharmacology; D006325:Heart Atria / Q000187:drug effects* / Q000378:metabolism; D006439:Hemodynamics / Q000187:drug effects*; D007093:Imidazoles / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves; D018547:Plant Stems; D011412:Propanolamines / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D011758:Pyrroles / Q000494:pharmacology; D011817:Rabbits; D018342:Receptors, Adrenergic, beta-1 / Q000378:metabolism*; D013318:Stroke Volume / Q000187:drug effects; D032106:Zanthoxylum
chemical_list: D002227:Carbazoles; D002316:Cardiotonic Agents; D002317:Cardiovascular Agents; D007093:Imidazoles; D010936:Plant Extracts; D011412:Propanolamines; D011758:Pyrroles; D018342:Receptors, Adrenergic, beta-1; C026777:ICI 118551; C057416:KT 5720; D009320:Atrial Natriuretic Factor; D011433:Propranolol; C049763:CGP 20712A; D000242:Cyclic AMP; D004110:Diltiazem