[Effect of dietary Lactobacillus casei on cholesterol metabolism in apoE-deficient mice].
OBJECTIVE
To explore the effect of dietary Lactobacillus casei on cholesterol metabolism in apoE-deficient mice in order to find the possible active components of Lactobacillus casei in anti-atherogenesis.


METHODS
ApoE-deficient mice were randomly divided into 4 groups: control group (A), Lactobacillus casei 10(8) cfu/ml group (B), Lactobacillus casei 10(10) cfu/ml group (C), Lactobacillus casei 10(12) cfu/ml group (D). ApoE-deficient mice were administrated with dietary contenting Lactobacillus casei for 16 weeks and the cholesterol levels of serum, liver, aorta in different groups were determined by enzymatic method.


RESULTS
When compared with control group, total cholesterol accumulation in aortas and livers showed a significant reduction in dietary mice fed with contenting Lactobacillus casei (P < 0.05). At the same time, it had higher HDL-C level compared to control group.


CONCLUSIONS
This result suggested that Lactobacillus casei could have the capacity of improvement.
Tang
Zhihong
Z
School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. tangzhh@mail.sysu.edu.cn
Zhu
Huilian
H
Xia
Min
M
Hou
Mengjun
M
D000818:Animals; D001057:Apolipoproteins E / Q000172:deficiency / Q000235:genetics*; D050197:Atherosclerosis / Q000235:genetics / Q000378:metabolism / Q000517:prevention & control*; D002784:Cholesterol / Q000378:metabolism*; D007780:Lacticaseibacillus casei; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D019936:Probiotics; D011897:Random Allocation
D001057:Apolipoproteins E; D002784:Cholesterol