Hemoglobin-based red blood cell substitutes and nitric oxide.
Hemoglobin-based oxygen carriers (HBOCs) have been studied for decades as red blood cell substitutes. Profound vasoconstrictor effects have limited the clinical utility of HBOCs and are attributable to avid scavenging of nitric oxide (NO). Inhaling NO can charge the body's stores of NO metabolites without producing hypotension and can prevent systemic hypertension induced when HBOCs are subsequently infused. Concurrent breathing of low NO doses can prevent pulmonary vasoconstriction after HBOC infusion without augmenting plasma methemoglobinemia.
Yu
Binglan
B
Anesthesia Center for Critical Care Research of the Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Bloch
Kenneth D
KD
Zapol
Warren M
WM
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001802:Blood Substitutes / Q000009:adverse effects / Q000494:pharmacology*; D002302:Cardiac Output / Q000187:drug effects; D016166:Free Radical Scavengers; D006454:Hemoglobins / Q000009:adverse effects / Q000494:pharmacology*; D006801:Humans; D006973:Hypertension / Q000139:chemically induced* / Q000378:metabolism / Q000517:prevention & control; D051379:Mice; D009569:Nitric Oxide / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D012756:Sheep; D014655:Vascular Resistance / Q000187:drug effects; D014661:Vasoconstriction / Q000187:drug effects*
D001802:Blood Substitutes; D016166:Free Radical Scavengers; D006454:Hemoglobins; C096798:HBOC 201; D009569:Nitric Oxide
ASAIO J. 2001 Sep-Oct;47(5):492-5
11575824
Am J Physiol Heart Circ Physiol. 2006 May;290(5):H1826-9
16299267
BMJ. 2007 Apr 14;334(7597):779
17383982
Circulation. 1991 Jun;83(6):2038-47
2040056
Free Radic Biol Med. 2008 Apr 15;44(8):1506-28
18261470
EuroIntervention. 2008 Mar;3(5):600-9
19608488
J Intern Med. 2003 May;253(5):508-17
12702028
Cardiovasc Res. 2007 Jul 15;75(2):339-48
17544387
J Intern Med. 2008 Jan;263(1):4-15
18042220
JAMA. 2008 May 21;299(19):2304-12
18443023
J Clin Invest. 1998 Jun 1;101(11):2497-505
9616221
Nat Rev Drug Discov. 2008 Feb;7(2):156-67
18167491
Proc Am Thorac Soc. 2006 Apr;3(2):170-2
16565427
N Engl J Med. 1997 Feb 27;336(9):597-604
9036320
Am J Physiol Heart Circ Physiol. 2006 Jul;291(1):H379-84
16443673
Crit Care Clin. 2009 Apr;25(2):373-82, Table of Contents
19341914
Anesthesiology. 2007 Aug;107(2):273-80
17667572
J Am Coll Surg. 2009 Jan;208(1):1-13
19228496
J Hypertens. 2007 Mar;25(3):599-608
17278977
Anesthesiology. 2008 Oct;109(4):675-82
18813047
J Lab Clin Med. 1998 Oct;132(4):313-9
9794703
J Clin Invest. 2005 Dec;115(12):3409-17
16294219
Am J Physiol Heart Circ Physiol. 2009 Feb;296(2):H524-33
19074675
Nat Biotechnol. 1998 Jul;16(7):672-6
9661203
J Clin Invest. 2001 Jul;108(2):279-87
11457881
Clin Pharmacol Ther. 1978 Jan;23(1):73-80
618711
Trans R Soc Trop Med Hyg. 2006 Sep;100(9):817-25
16527319