Three-dimensional T2-weighted MRI of the human femoral arterial vessel wall at 3.0 Tesla.
OBJECTIVE
To evaluate the potential use of a novel 3D turbo spin-echo (TSE) T2-weighted (T2w) technique for assessing the vessel wall in the superficial femoral artery at 3.0 T.


BACKGROUND
Magnetic resonance imaging can be used for the noninvasive assessment of atherosclerotic plaque burden in the peripheral circulation. Although black-blood 2D TSE techniques have been used for femoral arterial wall imaging, these techniques require prolonged imaging time to cover a large field of view required to cover the leg. Recently, variable-flip-angle 3D TSE T2w (SPACE) has been introduced as a fast vessel wall imaging technique with submillimeter spatial resolution. A systematic investigation of the application of this technique to femoral arterial wall imaging has yet to be performed.


METHODS
Fifteen healthy volunteers and 3 patients with peripheral arterial disease (PAD) underwent 3D SPACE imaging of the superficial femoral artery at 3.0 T, with the conventional 2D TSE T2w imaging as a reference. Muscle-lumen contrast to noise ratio (CNR) and wall/lumen volumes (WV, LV) were measured at the matched locations on the 3D and 2D image sets. Statistical comparison on a per-subject basis was conducted to determine the difference and agreement between 3D SPACE and the 2D TSE techniques.


RESULTS
The 3D SPACE data sets enabled vessel visualization from arbitrary orientation through multiplanar reformation technique. Muscle-lumen CNR was significantly higher with 3D SPACE than with the 2D TSE (3.12 +/- 0.84 vs. 2.17 +/- 0.34, P < 0.01). This trend was confirmed when CNR efficiency (CNR(eff)) values were further compared. A similar trend was observed in PAD patients (SPACE vs. 2D TSE T2w: CNR 2.35 +/- 0.13 vs. 1.77 +/- 0.25; CNR(eff) 15.35 +/- 0.61 vs. 3.59 +/- 2.62. all P < 0.05). Measurements of WV and LV from the 3D and 2D techniques were highly correlated in volunteers and PAD patients (volunteers, WV: linear regression r2 = 0.98, LV: r2 = 0.98, P < 0.001 for both; patients, WV: linear regression r2 = 0.96, LV: r2 = 0.94, P < 0.001 for both).


CONCLUSIONS
We established the feasibility of using the 3D SPACE technique for vessel wall imaging in the superficial femoral artery at 3.0T. High, isotropic-resolution SPACE images, with the aid of multiplanar reformation, enable superior vessel wall visualization. Superior blood signal suppression comparable to vessel wall morphologic measurements, and superior time efficiency compared to conventional 2D TSE imaging indicate the great potential of the SPACE method as a noninvasive imaging technique for the assessment of atherosclerotic plaque burden in PAD patients.
Zhang
Zhuoli
Z
Department of Radiology, Northwestern University, Chicago, IL, USA.
Fan
Zhaoyang
Z
Carroll
Timothy J
TJ
Chung
YiuCho
Y
Weale
Peter
P
Jerecic
Renate
R
Li
Debiao
D
D000328:Adult; D005260:Female; D005263:Femoral Artery / Q000473:pathology*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D016491:Peripheral Vascular Diseases / Q000175:diagnosis*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D055815:Young Adult
Magn Reson Med. 1998 Aug;40(2):298-310
9702712
J Magn Reson Imaging. 2007 May;25(5):1035-43
17457802
J Vasc Interv Radiol. 2003 Feb;14(2 Pt 1):227-31
12582191
Magn Reson Med. 2002 Mar;47(3):616-20
11870851
J Cardiovasc Magn Reson. 2007;9(1):33-42
17178678
J Am Coll Cardiol. 2006 Mar 21;47(6):1239-312
16545667
J Magn Reson Imaging. 2007 May;25(5):1000-6
17410562
J Cardiovasc Magn Reson. 2007;9(1):71-6
17178683
Am Heart J. 2008 Feb;155(2):348-55
18215607
Circulation. 2007 Feb 6;115(5):e69-171
17194875
J Magn Reson Imaging. 2005 Nov;22(5):628-33
16215965
Circulation. 1998 Aug 11;98(6):509-18
9714107
J Interv Cardiol. 2003 Apr;16(2):129-42
12768916
Radiology. 2001 Nov;221(2):285-99
11687667
J Gen Intern Med. 1997 Apr;12(4):209-15
9127224
Can J Cardiol. 2005 Oct;21(12):997-1006
16234879
Magn Reson Med. 2006 May;55(5):1030-7
16598719
J Magn Reson Imaging. 2007 Apr;25(4):815-23
17345637
Atherosclerosis. 2000 Jun;150(2):321-9
10856524
Coron Artery Dis. 2006 Sep;17(6):553-60
16905968
NMR Biomed. 2006 Oct;19(6):636-54
16986119