title: Single institute study of FLT3 mutation in acute myeloid leukemia with near tetraploidy in Serbia.
abstract: Patients with de novo acute myeloid leukemia (AML) and near-tetraploid or completely tetraploid karyotype at presentation are rare. We present four patients with near-tetraploidy/tetraploidy in a cohort of 426 consecutive AML patients (0.98%) in respect to their cytogenetic findings, immunophenotype pattern, response to chemotherapy, course of disease and molecular analyses including tyrosine kinase receptor FLT3 gene, NRAS gene, and tumour suppressor gene, p53. We have found FLT3/ITD mutation only in one patient among the four with near-tetraploidy. The main finding is that these patients had a variable clinical course, with two having a long period of remission (36 and 12 months) and two died, not having achieved remission.
authors.affiliation: Institute of Hematology, Medical School, 11000 Belgrade, Serbia. vdvd@mailcity.com
authors.forename: Vladimir
authors.initials: V
authors.lastname: Jurisić
authors.forename: Sonja
authors.initials: S
authors.lastname: Pavlović
authors.forename: Natasa
authors.initials: N
authors.lastname: Colović
authors.forename: Vesna
authors.initials: V
authors.lastname: Djordjevic
authors.forename: Vera
authors.initials: V
authors.lastname: Bunjevacki
authors.forename: Gradimir
authors.initials: G
authors.lastname: Janković
authors.forename: Milica
authors.initials: M
authors.lastname: Colović
mesh_terms: D006801:Humans; D016130:Immunophenotyping; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D011123:Polyploidy; D055771:Serbia; D051941:fms-Like Tyrosine Kinase 3 / Q000235:genetics*
chemical_list: C497970:FLT3 protein, human; D051941:fms-Like Tyrosine Kinase 3
references.citation: Ann Hematol. 2000 Jan;79(1):36-9
references.pmid: 10663619
references.citation: Ann Intern Med. 1985 Oct;103(4):620-5
references.pmid: 3862359
references.citation: Blood. 2001 Sep 15;98(6):1752-9
references.pmid: 11535508
references.citation: Cancer Genet Cytogenet. 1985 Jan 1;14(1-2):45-59
references.pmid: 3855276
references.citation: Blood. 2001 Apr 15;97(8):2434-9
references.pmid: 11290608
references.citation: Ann Hematol. 2007 Oct;86(10):741-7
references.pmid: 17579862
references.citation: Cancer Genet Cytogenet. 1995 Aug;83(1):1-4
references.pmid: 7656196
references.citation: Blood. 1983 Jan;61(1):71-8
references.pmid: 6571716
references.citation: Clin Lab Haematol. 2004 Feb;26(1):25-30
references.pmid: 14738434
references.citation: Eur J Intern Med. 2006 Oct;17(6):434-5
references.pmid: 16962953
references.citation: Blood. 2001 Jun 1;97(11):3589-95
references.pmid: 11369655
references.citation: Int J Hematol. 2001 Oct;74(3):316-21
references.pmid: 11721969