Characterization of chitin-metal silicates as binding superdisintegrants.
When chitin is used in pharmaceutical formulations, processing of chitin with metal silicates is advantageous, from both an industrial and pharmaceutical perspective, compared to processing using silicon dioxide. Unlike the use of acidic and basic reagents for the industrial preparation of chitin-silica particles, coprecipitation of metal silicates is dependent upon a simple replacement reaction between sodium silicate and metal chlorides. When coprecipitated onto chitin particles, aluminum, magnesium, or calcium silicates result in nonhygroscopic, highly compactable/disintegrable compacts. Disintegration and hardness parameters for coprocessed chitin compacts were investigated and found to be independent of the particle size. Capillary action appears to be the major contributor to both water uptake and the driving force for disintegration of compacts. The good compaction and compression properties shown by the chitin-metal silicates were found to be strongly dependent upon the type of metal silicate coprecipitated onto chitin. In addition, the inherent binding and disintegration abilities of chitin-metal silicates are useful in pharmaceutical applications when poorly compressible and/or highly nonpolar drugs need to be formulated.
Rashid
Iyad
I
The Jordanian Pharmaceutical Manufacturing Co., PO Box 94, Naor 11710, Jordan.
Daraghmeh
Nidal
N
Al-Remawi
Mayyas
M
Leharne
Stephen A
SA
Chowdhry
Babur Z
BZ
Badwan
Adnan
A
D000465:Algorithms; D002626:Chemistry, Pharmaceutical; D002686:Chitin / Q000737:chemistry*; D005079:Excipients; D006244:Hardness; D006245:Hardness Tests; D017633:Magnesium Silicates / Q000737:chemistry; D008670:Metals / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D010316:Particle Size; D011208:Powders; D017640:Silicates / Q000737:chemistry*; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D013607:Tablets; D014867:Water; D014961:X-Ray Diffraction
D005079:Excipients; D017633:Magnesium Silicates; D008670:Metals; D011208:Powders; D017640:Silicates; D013607:Tablets; D014867:Water; C005013:Florisil; D002686:Chitin