title: Comparison of assessment of oxygen consumption, Etest, and CLSI M38-A2 broth microdilution methods for evaluation of the susceptibility of Aspergillus fumigatus to posaconazole.
abstract: Posaconazole MICs for 50 Aspergillus fumigatus isolates with distinct genotypes were determined by three methods. MICs were > or = 0.5 microg/ml for 5, 11, and 15 strains by the CLSI reference M38-A2, Etest (48-h), and oxygen consumption methods, respectively. The levels of categorical agreement between the results obtained by the CLSI method and those obtained by the oxygen consumption and Etest methods were 80 and 84%, respectively.
authors.affiliation: IPATIMUP, Institute of Pathology and Molecular Immunology, University of Porto, Rua Dr. Roberto Frias, s/n, 4200-465 Porto, Portugal. ricjparaujo@yahoo.com
authors.forename: Ricardo
authors.initials: R
authors.lastname: Araujo
authors.forename: Ana
authors.initials: A
authors.lastname: Espinel-Ingroff
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D001232:Aspergillus fumigatus / Q000187:drug effects* / Q000378:metabolism; D025141:Drug Resistance, Fungal; D008826:Microbial Sensitivity Tests / Q000379:methods*; D010101:Oxygen Consumption / Q000187:drug effects*; D014230:Triazoles / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D014230:Triazoles; C101425:posaconazole
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