title: Modulation of taste sensitivity by GLP-1 signaling in taste buds.
abstract: Modulation of sensory function can help animals adjust to a changing external and internal environment. Even so, mechanisms for modulating taste sensitivity are poorly understood. Using immunohistochemical, biochemical, and behavioral approaches, we found that the peptide hormone glucagon-like peptide-1 (GLP-1) and its receptor (GLP-1R) are expressed in mammalian taste buds. Furthermore, we found that GLP-1 signaling plays an important role in the modulation of taste sensitivity: GLP-1R knockout mice exhibit a dramatic reduction in sweet taste sensitivity as well as an enhanced sensitivity to umami-tasting stimuli. Together, these findings suggest a novel paracrine mechanism for the hormonal modulation of taste function in mammals.
authors.affiliation: National Institute on Aging/NIH, Baltimore, Maryland, USA.
authors.forename: Bronwen
authors.initials: B
authors.lastname: Martin
authors.forename: Cedrick D
authors.initials: CD
authors.lastname: Dotson
authors.forename: Yu-Kyong
authors.initials: YK
authors.lastname: Shin
authors.forename: Sunggoan
authors.initials: S
authors.lastname: Ji
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Drucker
authors.forename: Stuart
authors.initials: S
authors.lastname: Maudsley
authors.forename: Steven D
authors.initials: SD
authors.lastname: Munger
mesh_terms: D000818:Animals; D052216:Glucagon-Like Peptide 1 / Q000378:metabolism*; D000067757:Glucagon-Like Peptide-1 Receptor; D051379:Mice; D018345:Mice, Knockout; D018027:Receptors, Glucagon / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D015398:Signal Transduction; D013649:Taste; D013650:Taste Buds / Q000378:metabolism*
chemical_list: C000593834:Glp1r protein, mouse; D000067757:Glucagon-Like Peptide-1 Receptor; D018027:Receptors, Glucagon; D052216:Glucagon-Like Peptide 1
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