title: Volumetric effects of motor cortex injury on recovery of dexterous movements.
abstract: Due to the heterogeneous nature of most brain injuries, the contributions of gray and white matter involvement to motor deficits and recovery potential remain obscure. We tested the hypothesis that duration of hand motor impairment and recovery of skilled arm and hand motor function depends on the volume of gray and white matter damage of the frontal lobe. Lesions of the primary motor cortex (M1), M1 + lateral premotor cortex (LPMC), M1 + LPMC + supplementary motor cortex (M2) or multifocal lesions affecting motor areas and medial prefrontal cortex were evaluated in rhesus monkeys. Fine hand motor function was quantitatively assessed pre-lesion and for 3-12 months post-lesion using two motor tests. White and gray matter lesion volumes were determined using histological and quantitative methods. Regression analyses showed that duration of fine hand motor impairment was strongly correlated (R(2)>0.8) with the volume of gray and white matter lesions, with white matter lesion volume being the primary predictor of impairment duration. Level of recovery of fine hand motor skill was also well correlated (R(2)>0.5) with gray and white matter lesion volume. In some monkeys post-lesion skill exceeded pre-lesion skill in one or both motor tasks demonstrating that continued post-injury task practice can improve motor performance after localized loss of frontal motor cortex. These findings will assist in interpreting acute motor deficits, predicting the time course and expected level of functional recovery, and designing therapeutic strategies in patients with localized frontal lobe injury or neurosurgical resection.
authors.affiliation: Department of Integrative Physiology, Motor Performance Laboratory, The University of Iowa, Iowa City, IA 52242, USA. warren-darling@uiowa.edu
authors.forename: Warren G
authors.initials: WG
authors.lastname: Darling
authors.forename: Marc A
authors.initials: MA
authors.lastname: Pizzimenti
authors.forename: Diane L
authors.initials: DL
authors.lastname: Rotella
authors.forename: Clayton R
authors.initials: CR
authors.lastname: Peterson
authors.forename: Stephanie M
authors.initials: SM
authors.lastname: Hynes
authors.forename: Jizhi
authors.initials: J
authors.lastname: Ge
authors.forename: Kathryn
authors.initials: K
authors.lastname: Solon
authors.forename: David W
authors.initials: DW
authors.lastname: McNeal
authors.forename: Kimberly S
authors.initials: KS
authors.lastname: Stilwell-Morecraft
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Morecraft
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D001930:Brain Injuries / Q000473:pathology* / Q000503:physiopathology; D004185:Disability Evaluation; D004195:Disease Models, Animal; D006225:Hand / Q000294:innervation / Q000503:physiopathology; D008253:Macaca mulatta; D009044:Motor Cortex / Q000293:injuries* / Q000473:pathology* / Q000503:physiopathology; D009048:Motor Skills / Q000502:physiology; D009069:Movement Disorders / Q000473:pathology* / Q000503:physiopathology; D009413:Nerve Fibers, Myelinated / Q000473:pathology; D009434:Neural Pathways / Q000293:injuries / Q000473:pathology / Q000503:physiopathology; D010291:Paresis / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D020127:Recovery of Function / Q000502:physiology*; D012720:Severity of Illness Index
references.citation: J Neurosci Methods. 2006 Jun 30;154(1-2):38-44
references.pmid: 16464505
references.citation: Neurorehabil Neural Repair. 2008 Jan-Feb;22(1):64-71
references.pmid: 17687024
references.citation: Stroke. 2000 Mar;31(3):672-9
references.pmid: 10700503
references.citation: J Neurophysiol. 1996 May;75(5):2144-9
references.pmid: 8734610
references.citation: J Neurophysiol. 1995 Feb;73(2):891-5
references.pmid: 7760146
references.citation: J Comp Neurol. 1992 Sep 15;323(3):341-58
references.pmid: 1460107
references.citation: J Neurol Sci. 1977 Jan-Feb;31(1):29-49
references.pmid: 833609
references.citation: J Neurosci. 2006 Mar 1;26(9):2579-82
references.pmid: 16510736
references.citation: Neuroscience. 2008 Nov 19;157(2):297-308
references.pmid: 18848605
references.citation: J Neurol Neurosurg Psychiatry. 1993 Apr;56(4):344-51
references.pmid: 8482953
references.citation: Neuroimage. 2005 May 15;26(1):57-65
references.pmid: 15862205
references.citation: Brain Behav Evol. 1975;12(3):161-200
references.pmid: 1212616
references.citation: J Neurosci Methods. 1999 Jul 15;89(2):111-7
references.pmid: 10491941
references.citation: Epilepsy Behav. 2005 Nov;7(3):559-62
references.pmid: 16194627
references.citation: Anat Embryol (Berl). 2000 Dec;202(6):443-74
references.pmid: 11131014
references.citation: Exp Brain Res. 1999 Sep;128(1-2):101-8
references.pmid: 10473747
references.citation: J Neurophysiol. 2008 Feb;99(2):773-86
references.pmid: 18094104
references.citation: Brain. 1955;78(2):174-98
references.pmid: 13239907
references.citation: Cerebrovasc Dis. 2001;11(3):273-81
references.pmid: 11306779
references.citation: J Physiol. 1986 Dec;381:497-527
references.pmid: 3625543
references.citation: Stroke. 2006 Sep;37(9):2348-53
references.pmid: 16931787
references.citation: Brain. 1983 Sep;106 (Pt 3):675-705
references.pmid: 6640276
references.citation: Science. 2007 Nov 16;318(5853):1150-5
references.pmid: 18006750
references.citation: Ann N Y Acad Sci. 1977;290:348-65
references.pmid: 96722
references.citation: Eur J Neurosci. 2003 Oct;18(7):1950-62
references.pmid: 14622227
references.citation: Brain Behav Evol. 1983;23(3-4):165-83
references.pmid: 6667369
references.citation: J Neurotrauma. 2007 Nov;24(11):1719-42
references.pmid: 18001202
references.citation: J Neurophysiol. 1989 Oct;62(4):959-70
references.pmid: 2681562
references.citation: Neuropharmacology. 2000 Mar 3;39(5):788-805
references.pmid: 10699445
references.citation: Curr Opin Neurobiol. 1996 Dec;6(6):773-81
references.pmid: 9000024
references.citation: Behav Brain Res. 2005 Jul 1;162(1):71-82
references.pmid: 15922067
references.citation: J Neurophysiol. 2005 Aug;94(2):1312-24
references.pmid: 15872062
references.citation: Stroke. 1999 Jul;30(7):1380-3
references.pmid: 10390310
references.citation: J Neurophysiol. 2007 Aug;98(2):1015-29
references.pmid: 17553948
references.citation: Somatosens Mot Res. 1997;14(4):268-80
references.pmid: 9443367
references.citation: J Comp Neurol. 1997 May 12;381(3):307-19
references.pmid: 9133570
references.citation: J Neurosci. 2008 Jan 30;28(5):1022-9
references.pmid: 18234880
references.citation: Stroke. 2001 Feb;32(2):424-30
references.pmid: 11157177
references.citation: Bull Chic Med Soc. 1949 Apr 30;51(44):863-6
references.pmid: 18151251
references.citation: Acta Neurochir (Wien). 1964;11:731-8
references.pmid: 14213898
references.citation: J Comp Neurol. 2004 Jan 26;469(1):37-69
references.pmid: 14689472
references.citation: Cereb Cortex. 1996 May-Jun;6(3):342-53
references.pmid: 8670662
references.citation: Epilepsy Behav. 2007 Nov;11(3):384-8
references.pmid: 17709300
references.citation: Brain. 1975 Jun;98(2):239-60
references.pmid: 1148818
references.citation: J Neurophysiol. 1998 Feb;79(2):537-54
references.pmid: 9463420
references.citation: Exp Brain Res. 2002 Jun;144(3):419-22
references.pmid: 12021823
references.citation: J Nerv Ment Dis. 1950 Jul;112(1):1-45
references.pmid: 15422381
references.citation: Exp Brain Res. 1985;59(1):125-38
references.pmid: 4018192
references.citation: Muscle Nerve. 2005 Sep;32(3):261-79
references.pmid: 15806550
references.citation: Brain. 1955;78(2):155-73
references.pmid: 13239906
references.citation: Brain. 1990 Feb;113 ( Pt 1):177-89
references.pmid: 2302531
references.citation: Trans Am Neurol Assoc. 1971;96:173-7
references.pmid: 5003552
references.citation: J Comp Neurol. 2007 Sep 10;504(2):149-67
references.pmid: 17626268
references.citation: J Anat. 1995 Dec;187 ( Pt 3):515-37
references.pmid: 8586553
references.citation: Handb Clin Neurol. 2007;82:15-37
references.pmid: 18808887
references.citation: J Comp Neurol. 2010 Mar 1;518(5):586-621
references.pmid: 20034062
references.citation: J Neurosci. 1992 Aug;12(8):2918-47
references.pmid: 1494940
references.citation: Exp Brain Res. 1999 Sep;128(1-2):149-59
references.pmid: 10473753
references.citation: J Microsc. 1987 Sep;147(Pt 3):229-63
references.pmid: 3430576
references.citation: J Neurosurg. 1991 Jul;75(1):62-8
references.pmid: 2045920
references.citation: J Neurotrauma. 2010 Mar;27(3):565-85
references.pmid: 20030560
references.citation: J Microsurg. 1980 Jan-Feb;1(4):305-20
references.pmid: 7430939
references.citation: J Comp Neurol. 2005 Oct 10;491(1):27-45
references.pmid: 16127695
references.citation: Brain. 2002 Jan;125(Pt 1):176-98
references.pmid: 11834603
references.citation: Brain. 2001 Jan;124(Pt 1):176-208
references.pmid: 11133797
references.citation: Neuropsychologia. 1978;16(2):151-68
references.pmid: 99681