Epinephrine kinetics in septic shock--a means to understand variable catecholamine efficiency?
It is well-established that the hemodynamic response to infusing catecholamines, the most frequently applied drugs for circulatory support during shock states, may vary markedly within and between individuals. In this context it is striking that only scarce data are available on the pharmacokinetics of catecholamines in critically ill patients. Furthermore, the existing literature comprises fairly equivocal observations. Abboud and colleagues now report that, in patients with septic shock, epinephrine kinetics are linear and its clearance directly depends on body weight and is inversely related to the severity of the disease. The authors conclude that the endogenous adrenal axis hormones do not assume any additional importance.
Calzia
Enrico
E
Sektion Anästhesiologische Pathopyhsiologie und Verfahrensentwicklung, Klinik für Anästhesiologie, Parkstrasse 11, 89073 Ulm, Germany. enrico.calzia@uni-ulm.de
Georgieff
Michael
M
Huber-Lang
Markus
M
Radermacher
Peter
P
D002395:Catecholamines / Q000494:pharmacology*; D004837:Epinephrine / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D012772:Shock, Septic / Q000188:drug therapy*; D016896:Treatment Outcome; D014662:Vasoconstrictor Agents / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use
D002395:Catecholamines; D014662:Vasoconstrictor Agents; D004837:Epinephrine
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