title: Activity-dependent extrinsic regulation of adult olfactory bulb and hippocampal neurogenesis.
abstract: The adult mammalian brain continuously generates new neurons in the olfactory bulb and hippocampus throughout life. Adult neurogenesis, a highly dynamic process, has been shown to be exquisitely modulated by neuronal circuit activity at different stages, from proliferation of adult neural progenitors, to differentiation, maturation, integration, and survival of newborn neurons in the adult brain. Strategic activity-dependent addition of new neurons into the existing neuronal circuitry represents a prominent form of structural plasticity and may contribute to specific brain functions, such as learning, memory, and mood modulation. Here we review extrinsic mechanisms through which adult neurogenesis is regulated by environmental cues, physiological learning-related stimuli, and neuronal activities.
authors.affiliation: The Solomon Snyder Department of Neuroscience, Institute for Cell Engineering , Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
authors.forename: Dengke K
authors.initials: DK
authors.lastname: Ma
authors.forename: Woon Ryoung
authors.initials: WR
authors.lastname: Kim
authors.forename: Guo-li
authors.initials: GL
authors.lastname: Ming
authors.forename: Hongjun
authors.initials: H
authors.lastname: Song
mesh_terms: D000818:Animals; D006624:Hippocampus / Q000166:cytology / Q000254:growth & development / Q000502:physiology*; D051379:Mice; D055495:Neurogenesis; D009830:Olfactory Bulb / Q000166:cytology / Q000254:growth & development / Q000502:physiology*
references.citation: Trends Neurosci. 2007 Jan;30(1):1-8
references.pmid: 17116335
references.citation: Nature. 2008 Feb 21;451(7181):1004-7
references.pmid: 18235445
references.citation: Science. 2007 Jul 6;317(5834):94-9
references.pmid: 17556551
references.citation: Annu Rev Neurosci. 2008;31:563-90
references.pmid: 18558867
references.citation: Prog Brain Res. 2007;163:217-32
references.pmid: 17765721
references.citation: J Neurosci. 2005 Nov 16;25(46):10729-39
references.pmid: 16291946
references.citation: Nat Neurosci. 2007 Aug;10(8):1003-11
references.pmid: 17603480
references.citation: Prog Brain Res. 2007;163:529-40
references.pmid: 17765736
references.citation: Nat Rev Neurosci. 2006 Mar;7(3):179-93
references.pmid: 16495940
references.citation: Brain Res. 1995 Mar 20;674(2):245-51
references.pmid: 7796103
references.citation: Neuron. 2005 Sep 15;47(6):803-15
references.pmid: 16157276
references.citation: J Neurosci. 2006 May 31;26(22):5888-93
references.pmid: 16738230
references.citation: Nat Neurosci. 2004 Apr;7(4):347-56
references.pmid: 15034584
references.citation: J Comp Neurol. 2001 Mar 12;431(3):311-9
references.pmid: 11170007
references.citation: Nat Neurosci. 1999 Mar;2(3):266-70
references.pmid: 10195220
references.citation: Curr Opin Neurobiol. 2005 Feb;15(1):121-8
references.pmid: 15721754
references.citation: Eur J Neurosci. 2008 Mar;27(6):1485-93
references.pmid: 18336568
references.citation: Prog Brain Res. 2007;163:755-73
references.pmid: 17765749
references.citation: J Neurosci. 2006 Oct 11;26(41):10508-13
references.pmid: 17035535
references.citation: J Neurosci. 2006 Apr 12;26(15):4095-103
references.pmid: 16611826
references.citation: Neuron. 2008 Aug 28;59(4):568-80
references.pmid: 18760694
references.citation: J Neurosci. 2007 Dec 26;27(52):14392-403
references.pmid: 18160647
references.citation: J Neurosci. 2008 Apr 23;28(17):4488-500
references.pmid: 18434527
references.citation: Eur J Neurosci. 2005 Dec;22(11):2863-70
references.pmid: 16324121
references.citation: Eur J Neurosci. 2001 Feb;13(3):512-20
references.pmid: 11168558
references.citation: Science. 2003 Jan 3;299(5603):117-20
references.pmid: 12511652
references.citation: Nat Neurosci. 2006 Feb;9(2):268-75
references.pmid: 16415867
references.citation: Nature. 2006 Aug 24;442(7105):929-33
references.pmid: 16906136
references.citation: J Physiol. 2008 Aug 15;586(16):3739-43
references.pmid: 18467361
references.citation: Nat Rev Neurosci. 2000 Dec;1(3):191-8
references.pmid: 11257907
references.citation: Prog Brain Res. 2007;163:577-99
references.pmid: 17765739
references.citation: Nature. 2006 Feb 2;439(7076):589-93
references.pmid: 16341203
references.citation: J Neurosci. 2007 Mar 21;27(12):3252-9
references.pmid: 17376985
references.citation: Science. 1996 Feb 16;271(5251):978-81
references.pmid: 8584933
references.citation: Behav Pharmacol. 2007 Sep;18(5-6):391-418
references.pmid: 17762509
references.citation: Nat Neurosci. 2005 Sep;8(9):1179-87
references.pmid: 16116450
references.citation: Nat Neurosci. 2007 Sep;10(9):1110-5
references.pmid: 17726477
references.citation: Curr Opin Neurobiol. 2005 Oct;15(5):514-20
references.pmid: 16144763
references.citation: Neurosurg Clin N Am. 2007 Jan;18(1):105-13, x
references.pmid: 17244558
references.citation: Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15570-5
references.pmid: 18832146
references.citation: J Neurosci. 2004 Sep 22;24(38):8354-65
references.pmid: 15385618
references.citation: Nat Neurosci. 1999 Mar;2(3):260-5
references.pmid: 10195219
references.citation: Neuron. 2007 May 24;54(4):559-66
references.pmid: 17521569
references.citation: J Neurosci. 2008 Jun 25;28(26):6720-30
references.pmid: 18579746
references.citation: Annu Rev Neurosci. 2005;28:223-50
references.pmid: 16022595
references.citation: PLoS Biol. 2007 Aug;5(8):e214
references.pmid: 17683201
references.citation: Curr Opin Neurobiol. 1999 Feb;9(1):135-41
references.pmid: 10072370
references.citation: Neuron. 2008 Aug 14;59(3):399-412
references.pmid: 18701066
references.citation: Science. 1977 Sep 9;197(4308):1092-4
references.pmid: 887941
references.citation: Nature. 1965 Aug 28;207(5000):953-6
references.pmid: 5886931
references.citation: Nature. 1997 Apr 3;386(6624):493-5
references.pmid: 9087407
references.citation: Curr Opin Neurobiol. 2004 Apr;14(2):186-91
references.pmid: 15082323
references.citation: Physiol Rev. 2005 Apr;85(2):523-69
references.pmid: 15788705
references.citation: Nat Med. 1998 Nov;4(11):1313-7
references.pmid: 9809557
references.citation: J Neurosci. 1995 Jun;15(6):4687-92
references.pmid: 7790933
references.citation: J Neurosci. 1997 Oct 1;17(19):7433-40
references.pmid: 9295389
references.citation: J Neurosci. 2002 Apr 1;22(7):2679-89
references.pmid: 11923433
references.citation: Curr Opin Neurobiol. 2008 Feb;18(1):108-15
references.pmid: 18514504
references.citation: Neuroscience. 1994 Aug;61(4):739-44
references.pmid: 7838373
references.citation: Cell. 2008 Feb 22;132(4):645-60
references.pmid: 18295581
references.citation: Nat Neurosci. 2007 Mar;10(3):355-62
references.pmid: 17277773
references.citation: J Physiol. 2008 Aug 15;586(16):3759-65
references.pmid: 18499723
references.citation: Mol Cell Neurosci. 2006 May-Jun;32(1-2):174-86
references.pmid: 16730455
references.citation: Neurobiol Learn Mem. 2006 Nov;86(3):322-9
references.pmid: 16824772
references.citation: Science. 2003 Aug 8;301(5634):805-9
references.pmid: 12907793
references.citation: Neuron. 2004 Mar 4;41(5):683-6
references.pmid: 15003168
references.citation: Physiol Rev. 2006 Jul;86(3):1033-48
references.pmid: 16816145
references.citation: Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1823-8
references.pmid: 10677540