title: Genome-wide location analysis reveals a role for Sub1 in RNA polymerase III transcription.
abstract: Human PC4 and the yeast ortholog Sub1 have multiple functions in RNA polymerase II transcription. Genome-wide mapping revealed that Sub1 is present on Pol III-transcribed genes. Sub1 was found to interact with components of the Pol III transcription system and to stimulate the initiation and reinitiation steps in a system reconstituted with all recombinant factors. Sub1 was required for optimal Pol III gene transcription in exponentially growing cells.
authors.affiliation: Commissariat à l'Energie Atomique, Institut de Biologie et de Technologies de Saclay, F-91101 Gif sur Yvette, France.
authors.forename: Arounie
authors.initials: A
authors.lastname: Tavenet
authors.forename: Audrey
authors.initials: A
authors.lastname: Suleau
authors.forename: Géraldine
authors.initials: G
authors.lastname: Dubreuil
authors.forename: Roberto
authors.initials: R
authors.lastname: Ferrari
authors.forename: Cécile
authors.initials: C
authors.lastname: Ducrot
authors.forename: Magali
authors.initials: M
authors.lastname: Michaut
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Aude
authors.forename: Giorgio
authors.initials: G
authors.lastname: Dieci
authors.forename: Olivier
authors.initials: O
authors.lastname: Lefebvre
authors.forename: Christine
authors.initials: C
authors.lastname: Conesa
authors.forename: Joël
authors.initials: J
authors.lastname: Acker
mesh_terms: D026481:Blotting, Far-Western; D047369:Chromatin Immunoprecipitation; D002874:Chromosome Mapping; D015825:Chromosomes, Fungal / Q000235:genetics; D004271:DNA, Fungal / Q000235:genetics / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000235:genetics* / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D015966:Gene Expression Regulation, Fungal; D016681:Genome, Fungal; D009154:Mutation; D020411:Oligonucleotide Array Sequence Analysis; D011485:Protein Binding; D012320:RNA Polymerase III / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000254:growth & development / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics* / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism; D019474:Transcription Factors, TFIII / Q000378:metabolism; D014158:Transcription, Genetic; D000098832:Transcription Factor TFIIIC
chemical_list: D004271:DNA, Fungal; D004268:DNA-Binding Proteins; C101206:SUB1 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors; D019474:Transcription Factors, TFIII; D000098832:Transcription Factor TFIIIC; D012320:RNA Polymerase III
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