Searching for MIND: microRNAs in neurodegenerative diseases.
In few years our understanding of microRNA (miRNA) biogenesis, molecular mechanisms by which miRNAs regulate gene expression, and the functional roles of miRNAs has been expanded. Interestingly, numerous miRNAs are expressed in a spatially and temporally controlled manner in the nervous system, suggesting that their posttrascriptional regulation may be particularly relevant in neural development and function. MiRNA studies in neurobiology showed their involvement in synaptic plasticity and brain diseases. In this review ,correlations between miRNA-mediated gene silencing and Alzheimer's, Parkinson's, and other neurodegenerative diseases will be discussed. Molecular and cellular neurobiological studies of the miRNAs in neurodegeneration represent the exploration of a new Frontier of miRNAs biology and the potential development of new diagnostic tests and genetic therapies for neurodegenerative diseases.
Barbato
Christian
C
European Brain Research Institute (EBRI), Fondazione EBRI- Rita Levi-Montalcini, Roma, Italy. c.barbato@inmm.cnr.it
Ruberti
Francesca
F
Cogoni
Carlo
C
D000818:Animals; D020868:Gene Silencing; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D019636:Neurodegenerative Diseases / Q000235:genetics*
D035683:MicroRNAs
J Cell Physiol. 2006 Jul;208(1):39-46
16447254
Neurobiol Dis. 2008 Mar;29(3):438-45
18082412
J Exp Med. 2007 Jul 9;204(7):1553-8
17606634
Nat Genet. 2006 Dec;38(12):1375-7
17072315
RNA. 2004 Mar;10(3):544-50
14970398
J Cell Sci. 2007 May 15;120(Pt 10):1707-16
17502481
Annu Rev Neurosci. 2008;31:439-77
18558863
Nat Rev Neurosci. 2006 Dec;7(12):911-20
17115073
Annu Rev Pathol. 2006;1:151-70
18039111
Eur J Neurosci. 2008 Jun;27(11):2803-20
18588526
Hum Mol Genet. 2008 Dec 1;17(23):3631-42
18723524
BMC Genomics. 2008 Mar 03;9:114
18315872
Am J Hum Genet. 2008 Feb;82(2):283-9
18252210
Nat Methods. 2007 Sep;4(9):721-6
17694064
Mol Cell. 2006 Oct 6;24(1):157-63
17018300
Mol Neurodegener. 2008 Aug 06;3:10
18684319
Acta Neuropathol. 1991;82(4):239-59
1759558
J Neurosci. 2008 Jan 30;28(5):1213-23
18234899
Nat Neurosci. 2008 Oct;11(10):1137-9
18758459
Neuroreport. 2007 Feb 12;18(3):297-300
17314675
Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2422-7
16461918
Front Biosci. 2008 May 01;13:4467-84
18508523
Nat Rev Mol Cell Biol. 2007 Feb;8(2):101-12
17245412
Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10820-5
18669659
Dev Biol. 2008 Mar 15;315(2):418-25
18262516
PLoS One. 2008;3(11):e3652
18987751
Nature. 2008 Sep 4;455(7209):58-63
18668040
J Biol Chem. 2009 Jan 23;284(4):1971-81
18986979
Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6415-20
18434550
Acta Neuropathol. 2007 Jul;114(1):5-22
17579875
Mamm Genome. 2008 Aug;19(7-8):541-51
18670804
Science. 2007 Aug 31;317(5842):1220-4
17761882
Cell. 2004 Jan 23;116(2):281-97
14744438
Nature. 2008 Sep 4;455(7209):64-71
18668037
J Alzheimers Dis. 2008 May;14(1):27-41
18525125
Genes Dev. 2005 Jul 15;19(14):1674-9
15985611