title: [Affects of transmission capability of nose mucociliary in radiotherapy].
abstract: OBJECTIVE
  To investigate the effects of radioactive ray on transmission capability of nose mucociliary.
  
  
  METHODS
  Forty-six patients with NPC were selected and saccharin clearance time (SCT) for 7 phases were detected in both pre- and post-radiotherapy respectively.
  
  
  RESULTS
  Among 46 patients with NPC, the shortest SCT was 247 seconds and the longest 601 seconds in pre-radiotherapy phases; from 4th week of introradiotherapy to 18 months of postradiotherapy, the longest SCT was in 12 months after radiotherapy, which was 903 seconds. There were no significant differences in SCT before radiotherapy and 18 months after radiotherapy. There were significant differences in SCT of preradiotherapy and introdiotherapy, post radiotherapy, after radiotherapy 3 months, 6 months, 12 months after radiotherapy.
  
  
  CONCLUSIONS
  Radiotherapy is the important factors in influencing transmission capability of nose cavity and sinus mucociliary and hints that gender and nasal cavity side don't affect SCT. Detection of SCT in different stages of NPC patients can be helpful to protect nasal mucous membrane effectively, and to reduce incidence rate of RNS.
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, Second People's Hospital of Guangdong, Guangzhou, 510310, China. huangping64@163.com
authors.forename: Xuehui
authors.initials: X
authors.lastname: Zhang
authors.forename: Xiangjun
authors.initials: X
authors.lastname: Fu
authors.forename: Jiannan
authors.initials: J
authors.lastname: Huang
authors.forename: Shupeng
authors.initials: S
authors.lastname: Xiao
authors.forename: Ping
authors.initials: P
authors.lastname: Xiao
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009079:Mucociliary Clearance / Q000528:radiation effects*; D009297:Nasal Mucosa / Q000503:physiopathology*; D009303:Nasopharyngeal Neoplasms / Q000503:physiopathology* / Q000532:radiotherapy*; D012439:Saccharin / Q000378:metabolism; D055815:Young Adult
chemical_list: D012439:Saccharin