title: Mycoplasma genitalium as a contributor to the multiple etiologies of cervicitis in women attending sexually transmitted disease clinics.
abstract: OBJECTIVE
  The purpose of this study was to investigate the prevalence of Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, and Mycoplasma genitalium, in women attending a sexually transmitted disease (STD) clinic, as well as the frequency of coinfections, and relationship of each organism to cervicitis.
  
  
  METHODS
  In this cross-sectional study of 324 women attending Baltimore City STD Clinics, C. trachomatis, N. gonorrhoeae, T. vaginalis, and M. genitalium were detected using nucleic acid amplification tests. Demographic characteristics and risk factors were ascertained.
  
  
  RESULTS
  Overall prevalence of infection with C. trachomatis, N. gonorrhoeae, T. vaginalis, and M. genitalium was found to be 11.1%, 4.6%, 15.3%, and 19.2%, respectively. Prevalence in women with cervicitis was 15.8%, 6%, 18.9%, and 28.6% for C. trachomatis, N. gonorrhoeae, T. vaginalis, and M. genitalium, respectively. Percentages of coinfections were high. C. trachomatis and M. genitalium were significantly associated with cervicitis in univariate analysis, but only M. genitalium was significantly associated with cervicitis (AOR: 2.5) in multiple logistic regression models.
  
  
  CONCLUSIONS
  Knowledge of the statistical association of M. genitalium with cervicitis in this study increases the need for further confirmation of the etiologic significance of this organism with cervicitis in more diverse populations. The high prevalence merits more study and may have implications for diagnosis and treatment of cervicitis.
authors.affiliation: Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. cgaydos@jhmi.edu
authors.forename: Charlotte
authors.initials: C
authors.lastname: Gaydos
authors.forename: Nancy E
authors.initials: NE
authors.lastname: Maldeis
authors.forename: Andrew
authors.initials: A
authors.lastname: Hardick
authors.forename: Justin
authors.initials: J
authors.lastname: Hardick
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Quinn
mesh_terms: D000328:Adult; D002692:Chlamydia trachomatis / Q000302:isolation & purification; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D016015:Logistic Models; D045704:Mycoplasma genitalium / Q000302:isolation & purification*; D009344:Neisseria gonorrhoeae / Q000302:isolation & purification; D012307:Risk Factors; D014246:Trichomonas vaginalis / Q000302:isolation & purification; D002575:Uterine Cervicitis / Q000209:etiology* / Q000382:microbiology
references.citation: Emerg Infect Dis. 2006 Jul;12(7):1149-52
references.pmid: 16836839
references.citation: J Clin Microbiol. 2005 Jan;43(1):127-31
references.pmid: 15634960
references.citation: J Clin Microbiol. 2003 Jan;41(1):304-9
references.pmid: 12517865
references.citation: Sex Transm Dis. 2008 Mar;35(3):250-4
references.pmid: 18490867
references.citation: Am J Obstet Gynecol. 1989 Jul;161(1):128-35
references.pmid: 2502013
references.citation: N Engl J Med. 1984 Jul 5;311(1):1-6
references.pmid: 6427611
references.citation: Sex Transm Infect. 2003 Apr;79(2):151-3
references.pmid: 12690140
references.citation: Infect Dis Obstet Gynecol. 2006;2006:30184
references.pmid: 17485798
references.citation: J Clin Microbiol. 2002 Apr;40(4):1451-5
references.pmid: 11923372
references.citation: Am J Obstet Gynecol. 1997 Nov;177(5):1184-7
references.pmid: 9396917
references.citation: J Clin Microbiol. 2006 Jun;44(6):2078-83
references.pmid: 16757601
references.citation: Sex Transm Infect. 2005 Dec;81(6):458-62
references.pmid: 16326846
references.citation: Int J STD AIDS. 1996;7 Suppl 2:17-24
references.pmid: 8799790
references.citation: Am J Obstet Gynecol. 2004 Jan;190(1):281-90
references.pmid: 14749674
references.citation: Perspect Sex Reprod Health. 2004 Jan-Feb;36(1):6-10
references.pmid: 14982671
references.citation: Ann Intern Med. 2003 Aug 5;139(3):178-85
references.pmid: 12899585
references.citation: Clin Infect Dis. 2009 Jan 1;48(1):41-7
references.pmid: 19025498
references.citation: Lancet. 1984 May 19;1(8386):1102-3
references.pmid: 6144831
references.citation: Lancet. 2002 Mar 2;359(9308):765-6
references.pmid: 11888591
references.citation: Am J Obstet Gynecol. 1986 Mar;154(3):556-64
references.pmid: 3485379
references.citation: J Clin Microbiol. 2006 Apr;44(4):1236-40
references.pmid: 16597844
references.citation: Sex Transm Infect. 2005 Feb;81(1):73-8
references.pmid: 15681728
references.citation: Genitourin Med. 1988 Jun;64(3):169-71
references.pmid: 3137151
references.citation: Infect Dis Clin North Am. 2005 Jun;19(2):333-49, viii
references.pmid: 15963875
references.citation: J Clin Microbiol. 2002 Jan;40(1):89-95
references.pmid: 11773098
references.citation: Int J STD AIDS. 2002 Mar;13(3):145-51
references.pmid: 11860689
references.citation: Eur J Epidemiol. 2001;17(1):89-95
references.pmid: 11523583
references.citation: Sex Transm Dis. 2005 Dec;32(12):725-8
references.pmid: 16314767
references.citation: J Clin Microbiol. 1998 Nov;36(11):3205-10
references.pmid: 9774566
references.citation: J Clin Microbiol. 2003 Jan;41(1):261-6
references.pmid: 12517858
references.citation: Sex Transm Dis. 2002 Jan;29(1):59-64
references.pmid: 11773880
references.citation: J Clin Microbiol. 2004 Oct;42(10):4636-40
references.pmid: 15472322
references.citation: Sex Transm Dis. 1997 May;24(5):284-6
references.pmid: 9153738
references.citation: Sex Transm Dis. 1997 Mar;24(3):131-41
references.pmid: 9132979
references.citation: J Clin Microbiol. 2003 Dec;41(12):5619-22
references.pmid: 14662951
references.citation: J Clin Microbiol. 2006 Nov;44(11):4197-9
references.pmid: 16943353
references.citation: Obstet Gynecol. 2002 Sep;100(3):579-84
references.pmid: 12220782
references.citation: Sex Transm Infect. 2003 Aug;79(4):318-9
references.pmid: 12902584
references.citation: J Clin Pathol. 2003 Aug;56(8):616-8
references.pmid: 12890814
references.citation: Sex Transm Infect. 2005 Dec;81(6):463-6
references.pmid: 16326847
references.citation: Clin Infect Dis. 2002 Sep 1;35(5):576-80
references.pmid: 12173132
references.citation: Am J Med. 1983 Jan;74(1):14-22
references.pmid: 6600371
references.citation: J Infect Dis. 2003 Feb 15;187(4):650-7
references.pmid: 12599082