Association of monocyte chemoattractant protein-1 with adipocyte number, insulin resistance and liver function markers.
BACKGROUND
Monocyte chemoattractant protein-1 (MCP-1) is an inflammatory chemokine known to induce adipocyte dedifferentiation and insulin resistance. Inflammation, insulin resistance, and obesity have been implicated in the pathogenesis of non-alcoholic fatty liver disease (NAFLD).


METHODS
Fasting plasma from 43 baboons were assayed for MCP-1, insulin, glucose, alanine aminotransferase (ALT), and aspartate aminotransferase (AST). Adipocyte number and volume were measured via biopsies of omental adipose tissue. The homeostatic model assessment method (HOMA) was used to estimate systemic insulin resistance.


RESULTS
Sex and age adjusted correlations were significant for MCP-1 with adipocyte number (r = -0.42; P = 0.01), adipocyte volume (r = 0.38; P = 0.02), HOMA (r = 0.45; P = 0.004), ALT (r = 0.46; P = 0.03) and AST (r = 0.45; P = 0.03).


CONCLUSIONS
These results suggest that MCP-1 is related with adipocyte dedifferentiation and systemic insulin resistance, thereby potentially contributing to the development of NAFLD.
Bose
Tanushree
T
Division of Nutritional Sciences, Department of Human Ecology, The University of Texas at Austin, Austin, TX, USA. tbose@calpoly.edu
Alvarenga
Juan Carlos Lopez
JC
Tejero
M Elizabeth
ME
Voruganti
V Saroja
VS
Proffitt
J Michael
JM
Freeland-Graves
Jeanne H
JH
Cole
Shelley A
SA
Comuzzie
Anthony G
AG
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D015415:Biomarkers / Q000097:blood; D018932:Chemokine CCL2 / Q000097:blood*; D005234:Fatty Liver / Q000097:blood / Q000209:etiology* / Q000473:pathology; D005260:Female; D007249:Inflammation / Q000097:blood / Q000150:complications*; D007333:Insulin Resistance; D050152:Intra-Abdominal Fat / Q000473:pathology*; D008111:Liver Function Tests; D008297:Male; D048529:Papio hamadryas
D015415:Biomarkers; D018932:Chemokine CCL2; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase
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