Serum 25-OH vitamin D levels in patients with fibromyalgia.
BACKGROUND
The association between low levels of 25-hydroxyvitamin D and non-specific musculoskeletal pain, including fibromyalgia syndrome, is controversial. Several studies have reported a "positive association" and two others found "no association."


OBJECTIVE
To test levels of 25OHD in patients with fibromyalgia syndrome and in matched controls.


METHODS
The study population comprised 68 premenopausal women with a diagnosis offibromyalgia and 82 age-matched premenopausal women without. The former were identified from the computerized medical databases of five primary care urban clinics in the south of Israel, and the control subjects were attending the participating clinics for regular periodic blood tests. For each patient, the matched control interview and blood test were performed within a week or two from the patient's interview and blood test, thus controlling for expected seasonal variations.


RESULTS
Serum 25OHD was measured using different cutoff levels and compared between the groups (< 30 ng/ml, < 20 ng/ml and <15 ng/ml). No statistically significant differences were found between the groups regardless of the cutoff level used. A logistic regression model for predicting women with 25OHD levels 20 ng/ml showed that all the variables examined in both groups (age, country of birth, education) were not statistically significant. We found the expected seasonal variations of 25OHD levels, though these were not statistically significant.


CONCLUSIONS
We found no association between fibromyalgia and low 25OHD levels as previously suggested in other studies.
Tandeter
Howard
H
Department of Family Medicine, Siaal Research Center for Family Medicine and Primary Care, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel. howard@bgu.ac.il
Grynbaum
Mirta
M
Zuili
Irene
I
Shany
Shraga
S
Shvartzman
Pesach
P
D000328:Adult; D016022:Case-Control Studies; D016208:Databases, Factual; D005260:Female; D005356:Fibromyalgia / Q000097:blood* / Q000453:epidemiology; D006801:Humans; D007557:Israel / Q000453:epidemiology; D016015:Logistic Models; D008875:Middle Aged; D011320:Primary Health Care / Q000706:statistics & numerical data; D012307:Risk Factors; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood* / Q000453:epidemiology
D014807:Vitamin D; C104450:25-hydroxyvitamin D