title: Metabotropic glutamate receptors and dendrodendritic synapses in the main olfactory bulb.
abstract: The main olfactory bulb (MOB) is the first site of synaptic processing in the central nervous system for odor information that is relayed from olfactory receptor neurons in the nasal cavity via the olfactory nerve (ON). Glutamate and ionotropic glutamate receptors (iGluRs) play a dominant role at ON synapses. Similarly, glutamate and iGluRs mediate dendrodendritic transmission between several populations of neurons within the MOB network. Neuroanatomical studies demonstrate that metabotropic glutamate receptors (mGluRs) are densely expressed through the MOB network, and they are particularly abundant at dendrodendritic synapses. Until recently, the physiological roles of mGluRs in the MOB were poorly understood. Over the past several years, mGluRs have been shown to play surprisingly powerful neuromodulatory roles at ON synapses and in dendrodendritic neurotransmission in the MOB. This chapter focuses on recent advances in our understanding of mGluR-mediated signaling components at dendrodendritic synapses.
authors.affiliation: Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA.
authors.forename: Hong-Wei
authors.initials: HW
authors.lastname: Dong
authors.forename: Thomas
authors.initials: T
authors.lastname: Heinbockel
authors.forename: Kathryn A
authors.initials: KA
authors.lastname: Hamilton
authors.forename: Abdallah
authors.initials: A
authors.lastname: Hayar
authors.forename: Matthew
authors.initials: M
authors.lastname: Ennis
mesh_terms: D000818:Animals; D003712:Dendrites / Q000502:physiology*; D006801:Humans; D051379:Mice; D009830:Olfactory Bulb / Q000502:physiology*; D009832:Olfactory Nerve / Q000502:physiology; D018094:Receptors, Metabotropic Glutamate / Q000502:physiology*; D013569:Synapses / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000502:physiology
chemical_list: D018094:Receptors, Metabotropic Glutamate; D005680:gamma-Aminobutyric Acid
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