title: Solitary cutaneous nodule of blastic plasmacytoid dendritic cell neoplasm progressing to overt leukemia cutis after chemotherapy: immunohistology and FISH analysis confirmed the diagnosis.
abstract: Blastic plasmacytoid dendritic cell (BPDC) neoplasm, formerly called blastic natural killer cell lymphoma or CD4+/CD56+ hematodermic neoplasm, is a rare tumor entity, now regarded to be derived from the plasmacytoid dendritic cell (PDC) lineage. Because over 90% of patients present with skin lesions usually early in their disease, dermatologists have to be familiar with the specific diagnostic features and the clinical course of this devastating disease. We present a woman with a long standing solitary skin tumor of BPDC neoplasm, who experienced a deleterious clinical course, which is typical for this disease. Phenotypic and karyotypic characteristics distinguishing this tumor from myelomonocytic leukemia with skin involvement are presented.
authors.affiliation: Departments of Dermatology and Venereology, Georg August University Göttingen, Göttingen, Germany. kkaune@gwdg.de
authors.forename: Kjell Matthias
authors.initials: KM
authors.lastname: Kaune
authors.forename: Mario
authors.initials: M
authors.lastname: Baumgart
authors.forename: Hans Peter
authors.initials: HP
authors.lastname: Bertsch
authors.forename: Christina
authors.initials: C
authors.lastname: Mitteldorf
authors.forename: Hans Konrad
authors.initials: HK
authors.lastname: Müller-Hermelink
authors.forename: Detlef
authors.initials: D
authors.lastname: Haase
authors.forename: B Michael
authors.initials: BM
authors.lastname: Ghadimi
authors.forename: Michael Peter
authors.initials: MP
authors.lastname: Schön
authors.forename: Christine
authors.initials: C
authors.lastname: Neumann
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000150:complications; D014408:Biomarkers, Tumor / Q000032:analysis; D003713:Dendritic Cells / Q000473:pathology*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D018450:Disease Progression; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D007938:Leukemia / Q000235:genetics / Q000473:pathology*; D008223:Lymphoma / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*; D016609:Neoplasms, Second Primary / Q000473:pathology*; D012878:Skin Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor