A hypervariable STR polymorphism in the complement factor I (CFI) gene: Asian-specific alleles.
In this study, a short tandem repeat (STR) polymorphism in intron 7 of the human complement factor I (CFI) gene was studied in 637 DNA samples obtained from African, German, Thai, and Japanese populations and German and Japanese families. A total of 41 alleles were observed and classified into two groups, L and H, based on size differences. Group H, which consisted of 16 alleles, was observed only in Thai and Japanese populations at frequencies of 0.162 and 0.116, respectively, and was strongly associated with c.1217A in exon 11 (CFI*Ah). The heterozygosity values ranged from 0.89 in German to 0.93 in Thai populations. This STR would be a useful supplementary marker for forensic individualization.
Yuasa
Isao
I
Division of Legal Medicine, Faculty of Medicine, Tottori University, Yonago, 683-8503, Japan. yuasai@med.tottori-u.ac.jp
Irizawa
Yoshito
Y
Nishimukai
Hiroaki
H
Fukumori
Yasuo
Y
Umetsu
Kazuo
K
Nakayashiki
Nori
N
Saitou
Naruya
N
Henke
Lotte
L
Henke
Jürgen
J
D017244:Complement Factor I / Q000235:genetics*; D005091:Exons; D005787:Gene Frequency; D006239:Haplotypes; D006579:Heterozygote; D006801:Humans; D007438:Introns; D015810:Linkage Disequilibrium; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D044469:Racial Groups / Q000235:genetics; D020080:Tandem Repeat Sequences
D017244:Complement Factor I
Forensic Sci Int Genet. 2008 Jun;2(3):e49-52
19083816
Nat Genet. 2007 Oct;39(10):1251-5
17828266
Int J Legal Med. 2007 Mar;121(2):85-9
16642351
Evol Bioinform Online. 2007 Feb 23;1:47-50
19325852
Forensic Sci Int Genet. 2008 Dec;3(1):7-13
19083860
Trends Genet. 2007 Sep;23(9):432-9
17655965
Int J Legal Med. 1997;110(4):175-6
9274938
J Hum Genet. 2008;53(11-12):1016-1021
18825487
Int J Legal Med. 2008 Jan;122(1):67-71
17273877
Biol Lett. 2007 Apr 22;3(2):218-23
17301009
Int J Legal Med. 1998;111(5):267-72
9728756
Int J Legal Med. 2009 May;123(3):259-61
19156434