title: A common mechanism in verb and noun naming deficits in Alzheimer's patients.
abstract: We tested the ability of Alzheimer's patients and elderly controls to name living and non-living nouns, and manner and instrument verbs. Patients' error patterns and relative performance with different categories showed evidence of graceful degradation for both nouns and verbs, with particular domain-specific impairments for living nouns and instrument verbs. Our results support feature-based, semantic representations for nouns and verbs and support the role of inter-correlated features in noun impairment, and the role of noun knowledge in instrument verb impairment.
authors.affiliation: University of South Carolina, Columbia, SC 29208, United States. almor@sc.edu
authors.forename: Amit
authors.initials: A
authors.lastname: Almor
authors.forename: Justin M
authors.initials: JM
authors.lastname: Aronoff
authors.forename: Maryellen C
authors.initials: MC
authors.lastname: MacDonald
authors.forename: Laura M
authors.initials: LM
authors.lastname: Gonnerman
authors.forename: Daniel
authors.initials: D
authors.lastname: Kempler
authors.forename: Houri
authors.initials: H
authors.lastname: Hintiryan
authors.forename: Unja L
authors.initials: UL
authors.lastname: Hayes
authors.forename: Sudha
authors.initials: S
authors.lastname: Arunachalam
authors.forename: Elaine S
authors.initials: ES
authors.lastname: Andersen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000503:physiopathology*; D003072:Cognition Disorders / Q000503:physiopathology; D005260:Female; D006801:Humans; D007806:Language Disorders / Q000503:physiopathology*; D008297:Male; D010364:Pattern Recognition, Visual / Q000502:physiology; D011930:Reaction Time / Q000502:physiology; D012660:Semantics; D013068:Speech Production Measurement; D014705:Verbal Behavior / Q000502:physiology; D014825:Vocabulary
references.citation: Brain Lang. 2006 Sep;98(3):332-40
references.pmid: 16843522
references.citation: Cortex. 1987 Sep;23(3):519-24
references.pmid: 3677738
references.citation: Brain Lang. 1997 Dec;60(3):443-63
references.pmid: 9398392
references.citation: Neuropsychologia. 2006;44(1):21-35
references.pmid: 15925392
references.citation: J Exp Psychol Hum Learn. 1980 Mar;6(2):174-215
references.pmid: 7373248
references.citation: J Exp Psychol Gen. 1997 Jun;126(2):99-130
references.pmid: 9163932
references.citation: Brain Lang. 2003 Sep;86(3):347-65
references.pmid: 12972366
references.citation: J Exp Psychol Gen. 1991 Dec;120(4):339-57
references.pmid: 1837294
references.citation: Neurology. 1996 Jul;47(1):178-82
references.pmid: 8710073
references.citation: Psychon Bull Rev. 1999 Mar;6(1):5-27
references.pmid: 12199314
references.citation: J Exp Psychol Gen. 2003 Jun;132(2):163-201
references.pmid: 12825636
references.citation: Psychol Rev. 1994 Oct;101(4):676-703
references.pmid: 7984711
references.citation: J Psychiatr Res. 1975 Nov;12(3):189-98
references.pmid: 1202204
references.citation: Neuropsychologia. 1995 Apr;33(4):441-59
references.pmid: 7617154
references.citation: Brain Lang. 1998 Oct 1;64(3):297-316
references.pmid: 9743544
references.citation: Cognition. 2002 Oct;85(3):B61-9
references.pmid: 12169413
references.citation: Brain. 1987 Oct;110 ( Pt 5):1273-96
references.pmid: 3676701
references.citation: Cognition. 2003 Sep;89(2):67-103
references.pmid: 12915295
references.citation: Brain Lang. 1997 Apr;57(2):254-79
references.pmid: 9126416
references.citation: Memory. 1995 Sep-Dec;3(3-4):463-95
references.pmid: 8574874
references.citation: Neuropsychology. 2001 Jul;15(3):371-9
references.pmid: 11499992
references.citation: Neurocase. 2001;7(6):459-71
references.pmid: 11788738
references.citation: J Cogn Neurosci. 1998 Jan;10(1):77-94
references.pmid: 9526084
references.citation: Brain. 1984 Sep;107 ( Pt 3):829-54
references.pmid: 6206910
references.citation: Cogn Psychol. 2004 Jun;48(4):422-88
references.pmid: 15099798
references.citation: Psychol Bull. 1993 Nov;114(3):510-32
references.pmid: 8272468
references.citation: Brain Lang. 2000 May;72(3):246-309
references.pmid: 10764520
references.citation: Cogn Neuropsychol. 2001 Mar 1;18(2):125-74
references.pmid: 20945209
references.citation: J Int Neuropsychol Soc. 1999 Nov;5(7):676-84
references.pmid: 10645709
references.citation: Cognition. 1991 Dec;41(1-3):197-229
references.pmid: 1790654
references.citation: Neurology. 1984 Jul;34(7):939-44
references.pmid: 6610841
references.citation: Trends Cogn Sci. 2001 Jun 1;5(6):244-252
references.pmid: 11390295
references.citation: J Cogn Neurosci. 1998 Jan;10(1):1-34
references.pmid: 9526080
references.citation: Behav Res Methods. 2006 Feb;38(1):153-7
references.pmid: 16817525
references.citation: Brain Lang. 1996 Jun;53(3):369-89
references.pmid: 8798334