Hepatoid carcinoma of the ovary. A case report and review of the literature.
Hepatoid carcinoma (HCO) is a rare ovarian tumor and is thought to be a different subtype from hepatoid-type yolk sac tumor based on its pathologic features. In contrast to hepatoid yolk sac tumor in which the patients are usually young, patients with HCO are elderly with a peak incidence during the sixth decade of life. None of the patients with HCO have had gonadal dysgenesis or recognizable germ cell components within the tumors. We describe a case of a 42-year-old woman who presented to our hospital complaining of abdominal pain. Physical examination and CT scan revealed a large tumor in the left adnexa. She underwent total hysterectomy and bilateral salpingo-oophorectomy with omentectomy. A left ovarian mass measuring 11 cm in diameter was found. Histological diagnosis was hepatoid carcinoma of the left ovary. Immunohistochemical findings suggest that hepatoid carcinoma of the ovary is probably a most likely variant of a common epithelial carcinoma by a process of neometaplasia or transdifferentiation.
Zizi-Sermpetzoglou
A
A
Department of Pathology, Tzaneion General Hospital of Pireaus, Piraeus, Greece. adserbet@yahoo.gr
Petrakopoulou
N
N
Nikolaidou
M E
ME
Tepelenis
N
N
Savvaidou
V
V
Vasilakaki
Th
T
D002277:Carcinoma / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000473:pathology*