title: Cytokine array comparisons of plasma from cycling fertile women on cycle day 5 and ovulation.
abstract: OBJECTIVE
  To identify plasma immuno-regulatory molecules up or down regulated between the follicular phase and ovulation of the human menstrual cycle.
  
  
  METHODS
  RayBio cytokine arrays were used to screen 174 immuno-regulatory molecules in plasma collected during the follicular phase at menstrual cycle day 5 and at ovulation from five healthy, non-smoking, fertile women of reproductive age not using hormonal contraception.
  
  
  RESULTS
  A total of 23 differentially expressed molecules were found: 10 molecules were differentially up-regulated and 13 down-regulated at ovulation compared with that at the follicular phase (alpha = 0.05, false discovery rate of 0.45).
  
  
  CONCLUSIONS
  Circulating immuno-regulatory molecules fluctuate over the menstrual cycle in healthy women. The combination of differentially expressed molecules suggests roles in cyclical regulation of angiogenesis and immune cell trafficking.
authors.affiliation: Department of Microbiology and Immunology, Queen's University, Kingston, ON, Canada. 7kh17@queensu.ca
authors.forename: Kota
authors.initials: K
authors.lastname: Hatta
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Bilinski
authors.forename: J Kimberly
authors.initials: JK
authors.lastname: Haladyn
authors.forename: Jessica J
authors.initials: JJ
authors.lastname: Roy
authors.forename: Julie
authors.initials: J
authors.lastname: Horrocks
authors.forename: Marianne J
authors.initials: MJ
authors.lastname: van den Heuvel
authors.forename: Victor K
authors.initials: VK
authors.lastname: Han
authors.forename: B Anne
authors.initials: BA
authors.lastname: Croy
mesh_terms: D016207:Cytokines / Q000097:blood* / Q000235:genetics / Q000276:immunology; D016208:Databases, Factual; D015536:Down-Regulation; D005260:Female; D046910:Fertile Period; D006801:Humans; D010060:Ovulation; D015854:Up-Regulation
chemical_list: D016207:Cytokines
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