Fighting tuberculosis: old drugs, new formulations.
This review reports the state of the art on innovative drug delivery strategies designed for antitubercular chemotherapeutics. The introduction contains the fundamental biological background concerning tuberculosis and a review of the current antitubercular therapy, and is followed by a critical report of the micrometric and nanometric particulate systems designed and investigated to improve tuberculosis chemotherapy.
Blasi
Paolo
P
University of Perugia, School of Pharmacy, Department of Chemistry and Technology of Drugs, Perugia, Italy. kaolino@unipg.it
Schoubben
Aurélie
A
Giovagnoli
Stefano
S
Rossi
Carlo
C
Ricci
Maurizio
M
D000818:Animals; D000995:Antitubercular Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D016503:Drug Delivery Systems; D006801:Humans; D008863:Microspheres; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000302:isolation & purification; D054118:Nanospheres; D014376:Tuberculosis / Q000188:drug therapy* / Q000382:microbiology / Q000503:physiopathology
D000995:Antitubercular Agents