Notch signaling: linking delta endocytosis and cell polarity.
Activation of Notch by its transmembrane ligand Delta requires the E3 ubiquitin ligases Neuralized or Mind bomb and endocytosis of the ubiquitinated ligand. In this issue of Developmental Cell, Ossipova et al. show that the polarity regulator PAR-1 phosphorylates Mind bomb, leading to the degradation of Mind bomb and to changes in cell fate due to loss of Notch signaling.
Krahn
Michael P
MP
Abteilung Stammzellbiologie, DFG Research Center for Molecular Physiology of the Brain, Georg-August-Universität Göttingen, Justus-von-Liebig-Weg 11, Göttingen 37077, Germany.
Wodarz
Andreas
A
D000818:Animals; D016764:Cell Polarity; D029721:Drosophila Proteins / Q000378:metabolism; D004705:Endocytosis / Q000502:physiology*; D038362:Glycogen Synthase Kinase 3; D047908:Intracellular Signaling Peptides and Proteins; D007527:Isoenzymes / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism*; D011493:Protein Kinase C / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D051880:Receptors, Notch / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism
D029721:Drosophila Proteins; D047908:Intracellular Signaling Peptides and Proteins; D007527:Isoenzymes; D008565:Membrane Proteins; D051880:Receptors, Notch; C064045:delta protein; C502570:Mib1 protein, Drosophila; D044767:Ubiquitin-Protein Ligases; D017346:Protein Serine-Threonine Kinases; D011493:Protein Kinase C; D038362:Glycogen Synthase Kinase 3; C472496:Par-1 protein, Drosophila