Rolling autogenetic dermis up to form a tube may be used as scaffold in tissue-engineered blood vessels.
Coronary and peripheral artery bypass grafting are widely being used to deal with vascular deficiencies currently, and a man-made synthetic tube or autogenous arteries or veins are needed a lot. But one's autogenous arteries or veins are limited, and artificial graft substitute isn't yet available in clinical applications because of many disadvantages. Various polymeric materials have been used as scaffolds, but without satisfying results due to intimal hyperplasia and the rate of degradation. Autogenetic dermis, which has the advantages of resistance to immunogenicity, good biocompatibility, and appropriate mechanical and physiological properties, has gained our attention to use it as a scaffold for tissue-engineered blood vessels. What is more, autogenetic dermis can be harvested easily. So we postulate that autogenetic dermis rolled up to form a tube may be an ideal scaffold for tissue-engineered blood vessels.
Diao
Jian-Sheng
JS
Institute of Plastic Surgery, Xijing Hospital, The Fourth Military Medical University, No 17 Changle Western Road, Xi'an 710032, PR China.
Yang
Sun
S
Xia
Wen-Sen
WS
Yi
Wei
W
Xia
Wei
W
Shu
Mao-Guo
MG
Zhang
Xi
X
Guo
Shu-Zhong
SZ
D000818:Animals; D001158:Arteries / Q000473:pathology; D001672:Biocompatible Materials; D001807:Blood Vessel Prosthesis; D019917:Blood Vessel Prosthesis Implantation / Q000379:methods; D020405:Dermis / Q000473:pathology / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D008962:Models, Theoretical; D013552:Swine; D023822:Tissue Engineering / Q000295:instrumentation / Q000379:methods*; D054457:Tissue Scaffolds; D014680:Veins / Q000473:pathology
D001672:Biocompatible Materials