title: Synthesis and biological activity of 2-(4,5-dihydroisoxazol-5-yl)-1,3,4-oxadiazoles.
abstract: Acid hydrazides were coupled with acrylic acid derivatives and cyclodehydration gave 1,3,4-oxadiazoles. Lastly, in-situ nitrile oxide formation from aryl oximes treated with sodium hypochlorite, and subsequent 1,3-dipolar cycloaddition to the exomethylene moiety delivered 2-(4,5-dihydroisoxazol-5-yl)-1,3,4-oxadiazoles. This library was evaluated in a high-throughput screen at Dow AgroSciences. Several compounds were active against fungal pathogens and pest insects.
authors.affiliation: Department of Chemistry, One Shields Ave., University of California, Davis, CA 95616, USA.
authors.forename: Kristin A
authors.initials: KA
authors.lastname: Milinkevich
authors.forename: Choong L
authors.initials: CL
authors.lastname: Yoo
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Sparks
authors.forename: Beth A
authors.initials: BA
authors.lastname: Lorsbach
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Kurth
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D007306:Insecticides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D010069:Oxadiazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D054852:Small Molecule Libraries
chemical_list: D000935:Antifungal Agents; D007306:Insecticides; D010069:Oxadiazoles; D054852:Small Molecule Libraries