title: Diversity-oriented synthesis of Kröhnke pyridines.
abstract: An efficient reagent-controlled approach for the regiospecific synthesis of new 2,2'-bipyridine derivatives in high-temperature water via microwave-assisted multicomponent reactions of aldehydes, 3-aryl-3-oxopropanenitrile, 2-acetylpyridine, and ammonium acetate is reported. Furthermore, aromatic aldehydes reacted with 1,2-diphenylethanone, resulting in structurally complex penta-arylpyridines. This chemistry provides an efficient and promising synthetic strategy to diversity-oriented construct poly arylpyridine skeleton.
authors.affiliation: School of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou, 221116, PR China.
authors.forename: Bo
authors.initials: B
authors.lastname: Jiang
authors.forename: Wen-Juan
authors.initials: WJ
authors.lastname: Hao
authors.forename: Xiang
authors.initials: X
authors.lastname: Wang
authors.forename: Feng
authors.initials: F
authors.lastname: Shi
authors.forename: Shu-Jiang
authors.initials: SJ
authors.lastname: Tu
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D006358:Hot Temperature; D008958:Models, Molecular; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000447:Aldehydes; D011725:Pyridines