[Pulmonary and cardiovascular syndrome due to hantavirus: clinical aspects of an emerging disease in southeastern Brazil].
Pulmonary and cardiovascular syndrome due to hantavirus is a disease caused by inhalation of aerosols from the excreta of wild rodents contaminated by viruses of the Bunyaviridae family. We studied the clinical and laboratory manifestations of 70 cases that occurred in the region of Ribeirão Preto, SP, Brazil, between 1998 and 2007. The frequency of symptoms was as follows: dyspnea (87%), fever (81%), coughing (44%), headache (34%), tachycardia (81%), low arterial blood pressure (56%), metabolic acidosis (57%), lymphocytopenia (51%), hematocrit > 45% (70%), leukocytosis with left deviation (67%), creatinine (51%) and urea (42%). Mortality (54.3%) occurred mainly on the fourth day. Respiratory insufficiency, low arterial blood pressure and shock occurred after 24 to 48 hours. High hematocrit and decreased platelet levels were signs strongly suggestive of the disease. The diagnostic hypothesis of atypical pneumonia was associated with a good prognosis (p = 0.0136). Fluid infusion greater than 2,000 ml and arterial hypotension were associated with a poor prognosis (p = 0.0286 and p = 0.0453).
Campos
Gelse Mazzoni
GM
Centro de Pesquisa em Virologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Av Bandeirantes 3900, Ribeirão Preto, SP. gelse@usp.br
Borges
Alessandra Abel
AA
Badra
Soraya Jabur
SJ
Figueiredo
Glauciane Garcia
GG
Souza
Ricardo Luiz Moro de
RL
Moreli
Marcos Lázaro
ML
Figueiredo
Luiz Tadeu Moraes
LT
D000328:Adult; D001938:Brazil / Q000453:epidemiology; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000401:mortality* / Q000628:therapy / Q000821:virology; D021821:Communicable Diseases, Emerging / Q000175:diagnosis / Q000401:mortality* / Q000628:therapy / Q000821:virology; D005260:Female; D018804:Hantavirus Pulmonary Syndrome / Q000175:diagnosis / Q000401:mortality* / Q000628:therapy; D006801:Humans; D015994:Incidence; D008297:Male; D011379:Prognosis; D012189:Retrospective Studies; D055815:Young Adult