title: No evidence demonstrating hepatotoxicity associated with hydroxycitric acid.
abstract: Although a number of cases of hepatotoxicity are associated with the use of Hydroxycut weight management products, it has been alleged that their effects are primarily due to the presence of hydroxycitric acid (HCA, as Super CitriMax) in the formulations. However, while these products contain up to 20 different ingredients, some do not contain HCA. Case studies reported to date have not considered in depth the literature on the numerous animal and human studies that have been conducted on the safety and efficacy of HCA. No HCA-associated hepatotoxicity or treatment-related adverse effects have been reported in these studies, and thus it is premature to make the assumptions presented in the recent case studies regarding Hydroxycut. If it is established in well controlled studies that the use of these formulations with and/or without HCA can result in the occurrence or progression of hepatotoxicity, additional studies should be conducted to characterize the causative factor(s).
authors.forename: Sidney J
authors.initials: SJ
authors.lastname: Stohs
authors.forename: Harry G
authors.initials: HG
authors.lastname: Preuss
authors.forename: Sunny E
authors.initials: SE
authors.lastname: Ohia
authors.forename: Gilbert R
authors.initials: GR
authors.lastname: Kaats
authors.forename: Carl L
authors.initials: CL
authors.lastname: Keen
authors.forename: Lonnie D
authors.initials: LD
authors.lastname: Williams
authors.forename: George A
authors.initials: GA
authors.lastname: Burdock
mesh_terms: D016907:Adverse Drug Reaction Reporting Systems; D000818:Animals; D019440:Anti-Obesity Agents / Q000009:adverse effects*; D002951:Citrates / Q000633:toxicity*; D002986:Clinical Trials as Topic; D019587:Dietary Supplements / Q000009:adverse effects*; D006801:Humans; D008099:Liver / Q000187:drug effects*; D015431:Weight Loss / Q000187:drug effects*
chemical_list: D019440:Anti-Obesity Agents; D002951:Citrates; C007999:hydroxycitric acid
references.citation: World J Gastroenterol. 2009 Apr 14;15(14):1786-7
references.pmid: 19360927
references.citation: Diabetes Obes Metab. 2004 May;6(3):171-80
references.pmid: 15056124
references.citation: Dig Dis Sci. 2009 Feb;54(2):406-8
references.pmid: 18661239
references.citation: J Med. 2004;35(1-6):33-48
references.pmid: 18084863
references.citation: Mol Cell Biochem. 2004 May;260(1-2):171-86
references.pmid: 15228099
references.citation: Toxicol Mech Methods. 2008;18(5):443-51
references.pmid: 20020869
references.citation: Mol Cell Biochem. 2003 Dec;254(1-2):339-46
references.pmid: 14674714
references.citation: Hepatology. 2004 Jul;40(1):6-9
references.pmid: 15239078
references.citation: Indian J Physiol Pharmacol. 2001 Jul;45(3):345-50
references.pmid: 11881574
references.citation: Int J Clin Pharmacol Res. 2005;25(3):133-44
references.pmid: 16366421
references.citation: Mol Cell Biochem. 2002 Sep;238(1-2):89-103
references.pmid: 12349913
references.citation: Toxicol Mech Methods. 2008;18(5):433-42
references.pmid: 20020868
references.citation: Phytother Res. 2002 Feb;16(1):80-3
references.pmid: 11807973
references.citation: Indian J Exp Biol. 2002 Jan;40(1):58-62
references.pmid: 12561970
references.citation: Food Chem Toxicol. 2004 Sep;42(9):1513-29
references.pmid: 15234082
references.citation: Gene Expr. 2004;11(5-6):251-62
references.pmid: 15200237