title: Fortuitous detection of endocervical adenocarcinoma in situ: a report of 2 cases.
abstract: BACKGROUND
  The Pap smear and oncogenic human papillomavirus (HPV) testing are highly effective in screening for cervical cancer precursors. Cervical glandular abnormalities, however, are more difficult to detect and monitor than are squamous lesions.
  
  
  METHODS
  We present 2 cases of premenopausal women with normal Pap smears, but oncogenic HPV infection and metrorrhagia. Biopsies revealed adenocarcinoma in situ, and cold-knife conization was performed.
  
  
  CONCLUSIONS
  Because glandular cancerous precursors can remain undetected by Pap screening, thorough evaluation of symptomatic patients with high-risk HPV is imperative.
authors.affiliation: Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, New York University School of Medicine, New York, New York, USA.
authors.forename: Elizabeth P
authors.initials: EP
authors.lastname: Gurney
authors.forename: Stephanie V
authors.initials: SV
authors.lastname: Blank
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D000328:Adult; D019092:Conization; D016889:Endometrial Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D008796:Metrorrhagia / Q000209:etiology / Q000473:pathology; D065006:Papanicolaou Test; D030361:Papillomavirus Infections / Q000473:pathology*; D011230:Precancerous Conditions / Q000473:pathology* / Q000821:virology; D017697:Premenopause; D002583:Uterine Cervical Neoplasms / Q000473:pathology*; D014626:Vaginal Smears / Q000379:methods*; D002578:Uterine Cervical Dysplasia / Q000473:pathology*