title: Chronic prenatal caffeine exposure impairs novel object recognition and radial arm maze behaviors in adult rats.
abstract: In this report, we demonstrate that chronic prenatal exposure to a moderate dose of caffeine disrupts novel object recognition and radial arm maze behaviors in adult male and female rats. Pregnant dams were administered either tap water or 75 mg/L caffeinated tap water throughout gestation. Oral self-administration in the drinking water led to an approximate maternal intake of 10mg/kg/day, equivalent to 2-3 cups of coffee/day in humans based on a metabolic body weight conversion. In adulthood, the offspring underwent testing on novel object recognition, radial arm maze, and Morris water maze tasks. Prenatal caffeine exposure was found to impair 24-h memory retention in the novel object recognition task and impair both working and reference memory in the radial arm maze. However, prenatal caffeine exposure did not alter Morris water maze performance in either a simple water maze procedure or in an advanced water maze procedure that included reversal and working memory paradigms. These findings demonstrate that chronic oral intake of caffeine throughout gestation can alter adult cognitive behaviors in rats.
authors.affiliation: Neuroscience Program, Michigan State University, East Lansing, MI 48824, USA. soellner@msu.edu
authors.forename: Deborah E
authors.initials: DE
authors.lastname: Soellner
authors.forename: Theresa
authors.initials: T
authors.lastname: Grandys
authors.forename: Joseph L
authors.initials: JL
authors.lastname: Nuñez
mesh_terms: D000818:Animals; D002110:Caffeine / Q000008:administration & dosage / Q000009:adverse effects*; D000697:Central Nervous System Stimulants / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D007859:Learning Disabilities / Q000139:chemically induced*; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008569:Memory Disorders / Q000139:chemically induced*; D008570:Memory, Short-Term / Q000187:drug effects; D009483:Neuropsychological Tests; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D021641:Recognition, Psychology / Q000187:drug effects; D012193:Reversal Learning / Q000187:drug effects
chemical_list: D000697:Central Nervous System Stimulants; D002110:Caffeine
references.citation: Semin Perinatol. 1981 Oct;5(4):310-4
references.pmid: 7302604
references.citation: Brain Res Dev Brain Res. 1996 Jul 20;94(2):205-23
references.pmid: 8836580
references.citation: Eur J Pharmacol. 2005 Feb 21;509(2-3):155-9
references.pmid: 15733550
references.citation: Neuroscience. 2008 Oct 15;156(3):630-9
references.pmid: 18706486
references.citation: J Pediatr. 1981 Apr;98(4):640-1
references.pmid: 7205496
references.citation: Life Sci. 1986 Mar 10;38(10):861-8
references.pmid: 3951312
references.citation: J Neurochem. 2002 Aug;82(3):625-34
references.pmid: 12153486
references.citation: Behav Pharmacol. 1993 Oct;4(5):541-544
references.pmid: 11224223
references.citation: Neuroscience. 1987 Sep;22(3):827-39
references.pmid: 2825071
references.citation: Synapse. 2005 Jul;57(1):8-16
references.pmid: 15858837
references.citation: J Neurochem. 2005 Jul;94(2):440-51
references.pmid: 15998294
references.citation: Behav Brain Res. 1988 Nov 1;31(1):47-59
references.pmid: 3228475
references.citation: Brain Res Mol Brain Res. 1993 Dec;20(4):313-27
references.pmid: 8114618
references.citation: Brain Res Dev Brain Res. 1993 Oct 15;75(2):193-9
references.pmid: 8261611
references.citation: Synapse. 1997 Dec;27(4):322-35
references.pmid: 9372555
references.citation: Arch Dis Child. 1979 Dec;54(12):946-9
references.pmid: 533298
references.citation: Neurosci Lett. 1987 Oct 16;81(1-2):69-74
references.pmid: 3696476
references.citation: Paediatr Perinat Epidemiol. 2003 Oct;17(4):324-31
references.pmid: 14629313
references.citation: Behav Brain Res. 1992 Oct 31;51(1):83-92
references.pmid: 1482548
references.citation: Pharmacol Rev. 1999 Mar;51(1):83-133
references.pmid: 10049999
references.citation: Prog Neurobiol. 1999 Nov;59(4):355-96
references.pmid: 10501634
references.citation: Physiol Behav. 1987;40(6):793-7
references.pmid: 3313453
references.citation: Cell Mol Life Sci. 2004 Apr;61(7-8):857-72
references.pmid: 15095008
references.citation: Neurotoxicol Teratol. 1991 Nov-Dec;13(6):641-7
references.pmid: 1779952
references.citation: J Pediatr. 1977 Mar;90(3):467-72
references.pmid: 14241
references.citation: J Neurosci Methods. 1984 May;11(1):47-60
references.pmid: 6471907
references.citation: Neuroreport. 2002 Jul 2;13(9):1199-204
references.pmid: 12151769
references.citation: Pharmacol Biochem Behav. 1991 Aug;39(4):883-8
references.pmid: 1763107
references.citation: Peptides. 1990 Sep-Oct;11(5):927-32
references.pmid: 2284203
references.citation: Eur J Clin Pharmacol. 1981;21(2):121-6
references.pmid: 7341280
references.citation: Synapse. 2006 Nov;60(6):450-5
references.pmid: 16892188
references.citation: Neurotoxicol Teratol. 1994 Nov-Dec;16(6):531-43
references.pmid: 7862054
references.citation: Mol Genet Metab. 2001 Sep-Oct;74(1-2):160-71
references.pmid: 11592813
references.citation: Neurobiol Learn Mem. 2007 Jan;87(1):42-56
references.pmid: 16824773
references.citation: PLoS One. 2008;3(12):e3977
references.pmid: 19092996
references.citation: J Appl Toxicol. 1982 Dec;2(6):307-14
references.pmid: 7185911
references.citation: Psychopharmacology (Berl). 2007 Mar;191(1):119-25
references.pmid: 17096081
references.citation: Pediatr Res. 2000 Aug;48(2):177-83
references.pmid: 10926292
references.citation: Neuropharmacology. 1991 May;30(5):489-96
references.pmid: 1865995
references.citation: Biol Neonate. 1987;51(6):332-9
references.pmid: 3607108
references.citation: Behav Brain Res. 2005 May 7;160(1):99-106
references.pmid: 15836904
references.citation: Brain Dev. 1984;6(4):355-61
references.pmid: 6496872
references.citation: Annu Rev Neurosci. 2001;24:31-55
references.pmid: 11283304
references.citation: Dev Pharmacol Ther. 1983;6(5):315-22
references.pmid: 6628163
references.citation: Brain Res Dev Brain Res. 1997 Jan 2;98(1):145-9
references.pmid: 9027414
references.citation: Toxicol Lett. 1988 Nov;44(1-2):167-75
references.pmid: 3188075
references.citation: J Endocrinol. 2003 Jul;178(1):45-54
references.pmid: 12844335