Solid-phase synthesis of 2-pyridones, 1,4-diazepines, and 1,4-oxazepines from resin-bound 3-amino-2-seleno ester.
A versatile combinatorial approach was developed for the rapid synthesis of 2-pyridones, 1,4-diazepines, and 1,4-oxazepines libraries. The synthetic strategy includes electrophilic addition, nucleophilic substitution, amine-acid condensation, Dieckmann condensation, lactamization, ester hydrolysis, lactonization, and oxidation-elimination.
Xu
Jian-Feng
JF
Department of Chemistry, Zhejiang University (Xixi Campus), Hangzhou 310028, PR China.
Huang
Xian
X
D001381:Azepines / Q000138:chemical synthesis*; D002851:Chromatography, High Pressure Liquid; D004952:Esters; D010077:Oxazepines / Q000138:chemical synthesis*; D011728:Pyridones / Q000138:chemical synthesis*; D018036:Selenium Compounds / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared
D001381:Azepines; D004952:Esters; D010077:Oxazepines; D011728:Pyridones; D018036:Selenium Compounds