title: Calcium-independent membrane damage by venom phospholipases A2.
abstract: Many snake venom phospholipase A(2)s (vPLA(2)s) present biological effects that are independent of hydrolytic activity. Here we review the evidence for the calcium-independent membrane damaging activity of vPLA(2)s, the possible relevance of this activity on their biological effects, and models for the mechanism of membrane permeabilization by these proteins.
authors.affiliation: Departamento de Química, FFCLRP-USP, Universidade de São Paulo, Brazil.
authors.forename: A H C
authors.initials: AH
authors.lastname: de Oliveira
authors.forename: E A
authors.initials: EA
authors.lastname: Aragão
authors.forename: J M
authors.initials: JM
authors.lastname: Sá
authors.forename: L
authors.initials: L
authors.lastname: Chioato
authors.forename: R
authors.initials: R
authors.lastname: Bugs-Bortoleto
authors.forename: R
authors.initials: R
authors.lastname: Ruller
authors.forename: T L
authors.initials: TL
authors.lastname: Ferreira
authors.forename: R J
authors.initials: RJ
authors.lastname: Ward
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D002463:Cell Membrane Permeability; D006801:Humans; D016297:Mutagenesis, Site-Directed; D054467:Phospholipases A2 / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D012910:Snake Venoms / Q000201:enzymology*; D012911:Snakes
chemical_list: D012910:Snake Venoms; D054467:Phospholipases A2