Role of prions in neuroprotection and neurodegeneration: a mechanism involving glutamate receptors?
There is increasing evidence that cellular prion protein plays important roles in neurodegeneration and neuroprotection. One of the possible mechanism by which this may occur is a functional inhibition of ionotropic glutamate receptors, including N-Methyl-D-Aspartate (NMDA) receptors. Here we review recent evidence implicating a possible interplay between NMDA receptors and prions in the context of neurodegenerative disorders. Such is a functional link between NMDA receptors and normal prion protein, and therefore possibly between these receptors and pathological prion isoforms, raises interesting therapeutic possibilities for prion diseases.
Zamponi
Gerald W
GW
Department of Physiology and Pharmacology, Hotchkiss Brain Institute, University of Calgary, CAL, CA. Zamponi@ucalgary.ca
Stys
Peter K
PK
D000818:Animals; D006801:Humans; D009410:Nerve Degeneration / Q000378:metabolism*; D017096:Prion Diseases / Q000378:metabolism; D011328:Prions / Q000378:metabolism*; D017470:Receptors, Glutamate / Q000378:metabolism*; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism
D011328:Prions; D017470:Receptors, Glutamate; D016194:Receptors, N-Methyl-D-Aspartate
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