title: Bioresistive identification of heat shock protein 90.
abstract: 90 kDa heat shock protein (HSP90) is a ubiquitous molecular chaperone and is one of the abundant proteins present in a cell under normal and stressed conditions. The adenosine triphosphate (ATP) binding region of HSP90 is currently under a great degree of study because of the interest of its role in cancer and protein maintenance; the binding of ATP to HSP90 induces a large conformational change in the protein as a result of the activity of different types of stressors within the cells. In the present paper, a simple microfluidic biosensor is proposed for the characterization of ATP-HSP90 interactions through the principle of bioresistive variation. The experimental results prove that the present biosensor system is highly suitable for the detection of heat shock proteins present in a real-time biological sample, which is very useful for in-situ biomedical applications and rapid pathogenic detections.
authors.forename: Arvind
authors.initials: A
authors.lastname: Chandrasekaran
authors.forename: Shanmugasundaram
authors.initials: S
authors.lastname: Pakkiriswami
authors.forename: Jian Liang
authors.initials: JL
authors.lastname: You
authors.forename: Ashwin
authors.initials: A
authors.lastname: Acharya
authors.forename: Muthukumaran
authors.initials: M
authors.lastname: Packirisamy
authors.forename: Denis
authors.initials: D
authors.lastname: Maxwell
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