title: [Application of Doehlert design for compatibility research of Dachengqi decoction].
abstract: OBJECTIVE
  To study the compatibility of dosage change of Zhishi, Houpo and Mangxiao affecting the yields of Anthraquinone components in Dachengqi decoction.
  
  
  METHODS
  Response surface methodology (RSM) with Doehlert design was adopted to evaluate the yields of Anthraquinone components in Dachengqi decoction by dosage change of Zhishi, Houpo and Mangxiao and the analysis time was shorten through a desirability function.
  
  
  RESULTS
  Results show that Anthraquinone components were got a high yields when the dosage ratio of Dachengqi decoction were compatible as follows: Dahuang-Zhishi-Houpo-Mangxiao (1:4:2. 31:2).
  
  
  CONCLUSIONS
  The Doehlert design with a desirability function, which allow a sequential response methodology, is a good methods, and, of cause, the mathematical model can be further extended and applied to the compatibility research of Chinese material medicine.
authors.affiliation: Department of Chinese Material Medicine Analysis, Guangzhou University of Chinese Medicine, Guangzhou 510006, China. xie_zhen@126.com
authors.forename: Zhen
authors.initials: Z
authors.lastname: Xie
authors.forename: Cheng
authors.initials: C
authors.lastname: Cao
authors.forename: Yuaner
authors.initials: Y
authors.lastname: Zeng
authors.forename: Bin
authors.initials: B
authors.lastname: Jiang
mesh_terms: D000880:Anthraquinones / Q000032:analysis; D004304:Dosage Forms; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000737:chemistry; D008956:Models, Chemical; D010936:Plant Extracts / Q000008:administration & dosage* / Q000737:chemistry*
chemical_list: D000880:Anthraquinones; D004304:Dosage Forms; D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; C477169:dachengqi decoction