High procalcitonin in a patient with drug hypersensitivity syndrome.
We present a patient who developed carbamazepine (CBZ)-induced Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) syndrome associated with high serum procalcitonin (PCT). The presentation (high fever, hepatosplenomegaly, leukocytosis), high PCT and CRP initially suggested sepsis, and he was treated with antibiotics, while CBZ was continued. The rash and hepatitis worsened. After withdrawal of CBZ, corticosteroid therapy was administered and the patient recovered with normalization of PCT. This case demonstrates that PCT may be increased in patients with DRESS. This is the first report of CBZ-induced DRESS associated with high PCT, and the second case of increased PCT in DRESS.
Bonaci-Nikolic
Branka
B
Institute of Allergy and Clinical Immunology, Clinical Center of Serbia, Belgrade, Serbia.
Jeremic
Ivica
I
Nikolic
Milos
M
Andrejevic
Sladjana
S
Lavadinovic
Lidija
L
D000293:Adolescent; D002116:Calcitonin / Q000096:biosynthesis* / Q000097:blood; D015740:Calcitonin Gene-Related Peptide; D002220:Carbamazepine / Q000009:adverse effects; D004342:Drug Hypersensitivity / Q000097:blood* / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D008297:Male; D011498:Protein Precursors / Q000096:biosynthesis* / Q000097:blood; D013577:Syndrome
C000606589:CALCA protein, human; D011498:Protein Precursors; D002220:Carbamazepine; D002116:Calcitonin; D015740:Calcitonin Gene-Related Peptide