New concepts in treatment of pediatric traumatic brain injury.
Emerging evidence suggests unique age-dependent responses following pediatric traumatic brain injury. The anesthesiologist plays a pivotal role in the acute treatment of the head-injured pediatric patient. This review provides important updates on the pathophysiology, diagnosis, and age-appropriate acute management of infants and children with severe traumatic brain injury. Areas of important clinical and basic science investigations germane to the anesthesiologist, such as the role of anesthetics and apoptosis in the developing brain, are discussed.
Huh
Jimmy W
JW
Critical Care and Pediatrics, Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Critical Care Office, Philadelphia, PA 19104-4399, USA. huh@email.chop.edu
Raghupathi
Ramesh
R
D000293:Adolescent; D000367:Age Factors; D000465:Algorithms; D000758:Anesthesia / Q000379:methods*; D017209:Apoptosis / Q000502:physiology; D001929:Brain Edema / Q000209:etiology; D002560:Cerebrovascular Circulation / Q000502:physiology; D002648:Child; D002675:Child, Preschool; D006259:Craniocerebral Trauma / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D019299:Decompression, Surgical; D004322:Drainage; D004630:Emergencies; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D019586:Intracranial Hypertension / Q000628:therapy; D010808:Physical Examination / Q000379:methods / Q000639:trends; D017410:Practice Guidelines as Topic
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