Phosphonate terminated PPH dendrimers: influence of pendant alkyl chains on the in vitro anti-HIV-1 properties.
The synthesis, characterization and in vitro anti-HIV activity of a series of generation one dendrimers having phosphonate groups with pendant alkyl chains are described. The influence of the lateral alkyl chains on the biological properties was correlated to (1)H-(1)H NOESY experiments.
Pérez-Anes
Alexandra
A
Laboratoire de Chimie de Coordination du CNRS, UPR 8241, 205 route de Narbonne, F-31077, Toulouse, France.
Spataro
Grégory
G
Coppel
Yannick
Y
Moog
Christiane
C
Blanzat
Muriel
M
Turrin
Cédric-Olivier
CO
Caminade
Anne-Marie
AM
Rico-Lattes
Isabelle
I
Majoral
Jean-Pierre
JP
D019380:Anti-HIV Agents / Q000138:chemical synthesis / Q000494:pharmacology; D002460:Cell Line; D050091:Dendrimers / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D063065:Organophosphonates / Q000737:chemistry*; D013329:Structure-Activity Relationship
D019380:Anti-HIV Agents; D050091:Dendrimers; D063065:Organophosphonates