title: [In vitro activity of gallic acid against Candida albicans biofilms].
abstract: OBJECTIVE
  To investigate the effects of gallic acid against Candida albicans biofilms in vitro.
  
  
  METHODS
  XTT reduction assay was performed to determine the effect of gallic acid on C. albicans biofilms and its adherence, and microscopic examination was conducted to assess the effect of gallic acid on morphogenesis of C. albicans biofilms; and cytotoxic assay was used to measure the adverse effects of gallic acid.
  
  
  RESULTS
  SMIC50, SMIC50 of gallic acid against C. albicans biofilms were 500, 1000 mg x L(-1), respectively; 100 mg x L(-1) and 1000 mg x L(-1) of gallic acid could inhibit the initial adherence and filamentous growth, and the agent showed poor cytotoxic activity.
  
  
  CONCLUSIONS
  gallic acid displayed potent activity against C. albicans biofilm.
authors.affiliation: School of Integrated Traditional and Western Medicine, Anhui University of Traditional Chinese Medicine, Hefei 230038, China. ahwcz63@sina.com
authors.forename: Changzhong
authors.initials: C
authors.lastname: Wang
authors.forename: Huijuan
authors.initials: H
authors.lastname: Cheng
authors.forename: Yan
authors.initials: Y
authors.lastname: Guan
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.forename: Yun
authors.initials: Y
authors.lastname: Yun
mesh_terms: D018441:Biofilms / Q000187:drug effects*; D002176:Candida albicans / Q000166:cytology / Q000187:drug effects* / Q000502:physiology*; D002448:Cell Adhesion / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005707:Gallic Acid / Q000494:pharmacology*
chemical_list: D005707:Gallic Acid