title: Does neoadjuvant chemotherapy for breast cancer increase complications during immediate breast reconstruction?
abstract: BACKGROUND
  Neoadjuvant chemotherapy (NAC) has been administered since the 1990s and is now one of the major treatments for breast cancer. It can achieve extremely positive results in some patients. Whether NAC affects immediate breast reconstruction (IBR) using an expander, however, remains unclear.
  
  
  METHODS
  A retrospective study was performed at Tokyo Medical and Dental University (TMDU) hospital. Seventy-five cases of immediate breast reconstruction using an expander were performed in 69 patients between January 2001 and January 2007. The patients were evaluated for tumor size, histological type, sites of invasion, staging, lymph node metastasis, NAC regimen, response to NAC, type of immediate breast reconstruction (IBR), complications, and prognosis.
  
  
  RESULTS
  In patients treated with an expander, there was no significant difference in the complication rate between those who underwent NAC and those who did not.
  
  
  CONCLUSIONS
  NAC did not increase the complication rate after IBR using an expander. However, for reconstruction using autologous tissue, more data are needed.
authors.affiliation: Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.forename: Hiroki
authors.initials: H
authors.lastname: Mori
authors.forename: Yuiro
authors.initials: Y
authors.lastname: Hata
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000601:surgery; D044584:Carcinoma, Ductal / Q000188:drug therapy* / Q000601:surgery; D005260:Female; D006801:Humans; D008875:Middle Aged; D020360:Neoadjuvant Therapy / Q000009:adverse effects*; D011183:Postoperative Complications / Q000209:etiology*; D019651:Plastic Surgery Procedures; D012189:Retrospective Studies; D013997:Time Factors; D015625:Tissue Expansion Devices