title: Retrospective analysis of outcome of pregnancy in women with congenital heart disease: single-centre experience from North India.
abstract: OBJECTIVE
  To study maternal and perinatal outcome in congenital heart disease (CHD) and to compare outcome between cyanotic and acyanotic CHD.
  
  
  METHODS
  A retrospective analysis of 196 cases of CHD was undertaken, and maternal and perinatal outcome of pregnancy was compared in cyanotic and acyanotic cases and between surgically corrected and uncorrected cases.
  
  
  RESULTS
  Maternal and perinatal outcome was better in the acyanotic group. Maternal complications included higher incidence of cardiac complications in cyanotic group, (33.3% vs 3.4% in acyanotic group, P = 0.001), abruption (12.5% vs nil) and pregnancy-induced hypertension (16.6% vs 5.2%). Rate of prematurity (25% vs 11.6%), intrauterine growth retardation (50% vs 15.1%, P = 0.003) and abortion (4.1% vs 2.1%) was higher in cyanotic group. Mean gestational age at delivery was better in corrected group, 37.13 vs 34.93 weeks in uncorrected group. There was no case of infective endocarditis. There were four cases of maternal mortality in cyanotic group, two of which were in women with Eisenmenger syndrome. In acyanotic heart disease one case died undelivered and one died on first postoperative day.
  
  
  CONCLUSIONS
  Maternal and perinatal outcome is better in acyanotic CHD compared to cyanotic CHD. Surgical correction of cardiac lesions prior to conception improves outcome.
authors.affiliation: Department of Obstetrics and Gynaecology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: Neelam
authors.initials: N
authors.lastname: Aggarwal
authors.forename: Vanita
authors.initials: V
authors.lastname: Suri
authors.forename: Harpreet
authors.initials: H
authors.lastname: Kaur
authors.forename: Seema
authors.initials: S
authors.lastname: Chopra
authors.forename: Meenakshi
authors.initials: M
authors.lastname: Rohila
authors.forename: Rajesh
authors.initials: R
authors.lastname: Vijayvergiya
mesh_terms: D000022:Abortion, Spontaneous / Q000453:epidemiology; D000328:Adult; D005260:Female; D005317:Fetal Growth Retardation; D005865:Gestational Age; D006330:Heart Defects, Congenital / Q000453:epidemiology*; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000453:epidemiology; D015994:Incidence; D007194:India / Q000453:epidemiology; D007752:Obstetric Labor, Premature / Q000453:epidemiology; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000453:epidemiology*; D011256:Pregnancy Outcome / Q000453:epidemiology*; D012189:Retrospective Studies; D013771:Tetralogy of Fallot / Q000453:epidemiology; D055815:Young Adult