Macrophage metalloelastase: stretching therapeutic opportunities.
While tissue macrophages are at the first line of microbial host defense, they are also convenient hideouts for pathogens escaping immune attack. Houghton et al. discovered that alveolar macrophage mobilizes macrophage metalloelastase to destroy bacteria present inside the cell.
He
Jeannie Q
JQ
Department of Immunology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
van Lookeren Campagne
Menno
M
Department of Immunology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA. menno@gene.com
D000818:Animals; D000900:Anti-Bacterial Agents / Q000378:metabolism*; D001419:Bacteria / Q000166:cytology / Q000187:drug effects; D006801:Humans; D008247:Lysosomes / Q000187:drug effects / Q000382:microbiology; D008264:Macrophages / Q000166:cytology / Q000187:drug effects / Q000201:enzymology; D053508:Matrix Metalloproteinase 12 / Q000378:metabolism*; D050296:Microbial Viability / Q000187:drug effects
D000900:Anti-Bacterial Agents; D053508:Matrix Metalloproteinase 12