title: The cell-based model of coagulation.
abstract: OBJECTIVE
  To review the current model describing coagulation processes, including the critical contributions of cells.
  
  
  METHODS
  Original research articles, scientific reviews, and textbooks.
  
  
  RESULTS
  Normal hemostasis is vital for prevention of blood loss, but controls are necessary to limit coagulation to the site of injury. The previous cascade model of blood coagulation, although refined and updated over the last few decades, is flawed as a description of how hemostasis occurs in vivo. The recently proposed model incorporates the vital role of cells in coagulation processes, and corrects deficiencies of the older cascade models.
  
  
  CONCLUSIONS
  The cell-based model of coagulation provides a description of coagulation that more likely reflects hemostatic processes as they occur in vivo.
authors.affiliation: Department of Internal Medicine, University of Illinois at Urbana-Champaign, Urbana, IL, USA. sasmith6@illinois.edu
authors.forename: Stephanie A
authors.initials: SA
authors.lastname: Smith
mesh_terms: D000818:Animals; D001777:Blood Coagulation / Q000502:physiology*; D001779:Blood Coagulation Factors / Q000378:metabolism; D006801:Humans; D008954:Models, Biological
chemical_list: D001779:Blood Coagulation Factors