title: Inbreeding, pedigree size, and the most recent common ancestor of humanity.
abstract: How many generations ago did the common ancestor of all present-day individuals live, and how does inbreeding affect this estimate? The number of ancestors within family trees determines the timing of the most recent common ancestor of humanity. However, mating is often non-random and inbreeding is ubiquitous in natural populations. Rates of pedigree growth are found for multiple types of inbreeding. This data is then combined with models of global population structure to estimate biparental coalescence times. When pedigrees for regular systems of mating are constructed, the growth rates of inbred populations contain Fibonacci n-step constants. The timing of the most recent common ancestor depends on global population structure, the mean rate of pedigree growth, mean fitness, and current population size. Inbreeding reduces the number of ancestors in a pedigree, pushing back global common ancestry times. These results are consistent with the remarkable findings of previous studies: all humanity shares common ancestry in the recent past.
authors.affiliation: Graduate Program in Genetics, Department of Ecology and Evolution, Stony Brook University, Stony Brook, NY 11794-5222, USA. Joseph.Lachance@sunysb.edu
authors.forename: Joseph
authors.initials: J
authors.lastname: Lachance
mesh_terms: D000818:Animals; D005260:Female; D015186:Hominidae / Q000235:genetics / Q000502:physiology*; D007178:Inbreeding; D008297:Male; D008954:Models, Biological; D010375:Pedigree; D011156:Population Density; D012098:Reproduction / Q000502:physiology; D013997:Time Factors
references.citation: Nature. 2004 Sep 30;431(7008):562-6
references.pmid: 15457259
references.citation: Science. 2008 Feb 8;319(5864):813-6
references.pmid: 18258915
references.citation: Ann Hum Genet. 2005 Sep;69(Pt 5):549-58
references.pmid: 16138913
references.citation: Theor Popul Biol. 2008 Sep;74(2):182-90
references.pmid: 18634815
references.citation: Am J Hum Genet. 2003 Mar;72(3):717-21
references.pmid: 12592608
references.citation: Hum Hered. 1997 May-Jun;47(3):165-72
references.pmid: 9156328
references.citation: Am J Hum Genet. 2006 Feb;78(2):334-8
references.pmid: 16358217
references.citation: Science. 1995 Dec 22;270(5244):1930-6
references.pmid: 8533083
references.citation: Genetics. 1921 Mar;6(2):124-43
references.pmid: 17245959
references.citation: Genetics. 1987 Oct;117(2):353-60
references.pmid: 3666446
references.citation: Genet Res. 1999 Dec;74(3):329-40
references.pmid: 10689809
references.citation: Proc Natl Acad Sci U S A. 1996 Dec 24;93(26):15276-8
references.pmid: 8986801
references.citation: Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):7360-5
references.pmid: 10861004
references.citation: PLoS Genet. 2008 Sep 26;4(9):e1000200
references.pmid: 18818760
references.citation: Nature. 2004 Sep 30;431(7008):518-9
references.pmid: 15457241
references.citation: Nature. 1987 Jan 1-7;325(6099):31-6
references.pmid: 3025745
references.citation: Nat Genet. 1994 Oct;8(2):117-21
references.pmid: 7842008
references.citation: Genet Res. 1991 Oct;58(2):167-75
references.pmid: 1765264
references.citation: Clin Genet. 2001 Aug;60(2):89-98
references.pmid: 11553039
references.citation: Genetics. 1998 May;149(1):429-34
references.pmid: 9584114