title: O-Spiro C-aryl glucosides as novel sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors.
abstract: Two series of O-spiro C-aryl glucosides were synthesized and tested for inhibition of hSGLT1 and hSGLT2. 6'-O-Spiro C-aryl glucosides exhibited potent in vitro hSGLT2 inhibitory activity but 2'-O-spiro C-aryl glucosides showed no in vitro hSGLT2 inhibitory activity at a screening concentration of 1microM.
authors.affiliation: Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, Sichuan 610041, PR China. xubaihua2002@163.com
authors.forename: Baihua
authors.initials: B
authors.lastname: Xu
authors.forename: Binhua
authors.initials: B
authors.lastname: Lv
authors.forename: Yan
authors.initials: Y
authors.lastname: Feng
authors.forename: Ge
authors.initials: G
authors.lastname: Xu
authors.forename: Jiyan
authors.initials: J
authors.lastname: Du
authors.forename: Ajith
authors.initials: A
authors.lastname: Welihinda
authors.forename: Zelin
authors.initials: Z
authors.lastname: Sheng
authors.forename: Brian
authors.initials: B
authors.lastname: Seed
authors.forename: Yuanwei
authors.initials: Y
authors.lastname: Chen
mesh_terms: D005947:Glucose / Q000378:metabolism; D005960:Glucosides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D051269:Sodium-Glucose Transporter 1 / Q000037:antagonists & inhibitors / Q000378:metabolism; D051297:Sodium-Glucose Transporter 2 / Q000378:metabolism; D000077203:Sodium-Glucose Transporter 2 Inhibitors; D013141:Spiro Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D005960:Glucosides; D051269:Sodium-Glucose Transporter 1; D051297:Sodium-Glucose Transporter 2; D000077203:Sodium-Glucose Transporter 2 Inhibitors; D013141:Spiro Compounds; D005947:Glucose