Total-tau and phospho-tau(181Thr) in cerebrospinal fluid of neurologically intact population increase with age.
Tau protein is a microtubule-associated molecule playing a crucial role in maintenance of neuronal integrity and in many neurodegenerative processes; its pathology has become a hallmark feature at the tissue level. The aim of the study was to estimate total tau and phospho-tau (Thr181) concentrations in cerebrospinal fluid of healthy population. Cerebrospinal fluid samples were taken from 129 subjects (age 18-77 years) without known neurologic or psychiatric condition. Both total-tau and phospho-tau levels showed significant correlation with age, which was more pronounced in older population.
Jaworski
J
J
Department of Neurology, Medical University of Lublin, Lublin, Poland. jjawor@onet.eu
Psujek
M
M
Bartosik-Psujek
H
H
D000328:Adult; D017677:Age Distribution; D000368:Aged; D000375:Aging / Q000134:cerebrospinal fluid*; D016001:Confidence Intervals; D005260:Female; D006262:Health; D006801:Humans; D008297:Male; D008875:Middle Aged; D010750:Phosphoproteins / Q000134:cerebrospinal fluid*; D012044:Regression Analysis; D055815:Young Adult; D016875:tau Proteins / Q000134:cerebrospinal fluid*
D010750:Phosphoproteins; D016875:tau Proteins