title: DLK is a novel immunohistochemical marker for adrenal gland tumors.
abstract: Delta-like protein (DLK) is expressed in fetal and adult adrenal glands. We have investigated if this expression is maintained in adrenal gland-derived tumors. All the studied 37 cortical tumors, including five carcinomas, stained positively as well as the 13 examined pheochromocytomas. Thus, DLK is a very sensitive marker for adrenal tumors of cortical and medullary origin. Renal cell carcinomas, presenting the major differential diagnostic problem for cortical tumors, were all negative, as well as melanomas, which are similar to high portion of adrenocortical tumors that react with melan-A. However, all paragangliomas, some carcinoids, and thyroid medullary carcinomas were also positive for DLK. Therefore, this novel immunohistochemical marker seems useful for the identification of adrenocortical tumors while it has limited value for the distinction of pheochromocytomas from diagnostically related neuroendocrine tumors.
authors.affiliation: First Department of Pathology and Experimental Cancer Research, Semmelweis University, Ulloi út 26, Budapest, 1085, Hungary.
authors.forename: Eszter
authors.initials: E
authors.lastname: Turányi
authors.forename: Katalin
authors.initials: K
authors.lastname: Dezso
authors.forename: Sándor
authors.initials: S
authors.lastname: Paku
authors.forename: Peter
authors.initials: P
authors.lastname: Nagy
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000737:chemistry*; D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis*; D002135:Calcium-Binding Proteins; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D036341:Intercellular Signaling Peptides and Proteins / Q000032:analysis*; D047908:Intracellular Signaling Peptides and Proteins; D008297:Male; D008565:Membrane Proteins / Q000032:analysis*; D008875:Middle Aged
chemical_list: D014408:Biomarkers, Tumor; D002135:Calcium-Binding Proteins; C512941:DLK1 protein, human; D036341:Intercellular Signaling Peptides and Proteins; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; C064045:delta protein
references.citation: Nucleic Acids Res. 1990 Feb 11;18(3):685
references.pmid: 2308864
references.citation: Differentiation. 2000 Aug;66(1):49-59
references.pmid: 10997592
references.citation: Histol Histopathol. 2000 Jan;15(1):119-29
references.pmid: 10668203
references.citation: Virchows Arch. 2008 Apr;452(4):443-8
references.pmid: 18236070
references.citation: Endocrinology. 1998 Jul;139(7):3316-28
references.pmid: 9645708
references.citation: Appl Immunohistochem Mol Morphol. 2008 Jan;16(1):32-9
references.pmid: 18091323
references.citation: Horm Res. 2008;70(5):294-9
references.pmid: 18824868
references.citation: Hum Reprod. 1993 Apr;8(4):635-41
references.pmid: 8501199
references.citation: J Biol Chem. 1993 Feb 25;268(6):3817-20
references.pmid: 8095043
references.citation: Appl Immunohistochem Mol Morphol. 2005 Dec;13(4):347-52
references.pmid: 16280664
references.citation: Semin Diagn Pathol. 2005 Feb;22(1):51-68
references.pmid: 16512599
references.citation: Eur J Biochem. 1994 Oct 1;225(1):83-92
references.pmid: 7925474
references.citation: Histochem Cell Biol. 1996 Dec;106(6):535-42
references.pmid: 8985741
references.citation: Mod Pathol. 2005 May;18(5):656-62
references.pmid: 15605081