Very late stent thrombosis 42 months after implantation of sirolimus-eluting stent and discontinuation of antiplatelet therapy.
Although safety profiles of sirolimus-eluting stents do not seem to differ in short-to-medium term from those of bare-metal stents, late stent thrombosis after deployment of drug-eluting stents has emerged as a potential safety concern in the era of high-pressure stent implantation. Here, we describe the case of a patient with acute myocardial infarction due to stent thrombosis of a sirolimus-eluting stent 42 months after stent deployment and 5 weeks after discontinuation of aspirin treatment. To the best of our knowledge, this is one of the most delayed cases of sirolimus-eluting stent thrombosis described so far. The case emphasizes the potential risk that late stent thrombosis can unpredictably occur at any time point after drug-eluting stent deployment.
Sibbing
Dirk
D
Department of Cardiology, Deutsches Herzzentrum München & 1. Medizinische Klinik, Technische Universität München, Lazarettstrasse 36, 80636 München, Germany.
Laugwitz
Karl-Ludwig
KL
Bott-Flügel
Lorenz
L
Pache
Jürgen
J
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15870416
Lancet. 2004 Oct 23-29;364(9444):1519-21
15500897
Nat Clin Pract Cardiovasc Med. 2006 Dec;3(12):638-9
17122791
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14744976
Circulation. 2006 Feb 28;113(8):1108-13
16490815
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15963413