title: Constituents from fruits of Cupressus sempervirens.
abstract: Two new phenolic glycosides (1, 2), along with fourteen known compounds (3-16) have been isolated from the fruit of Cupressus sempervirens. The structures of these compounds were determined by spectroscopic analysis and were evaluated for their inhibitory activity against glycogen phosphorylase and glucose-6-phosphatase enzymes. Compounds 14 showed a moderate inhibition against glucose-6-phosphatase and 15 against glycogen phosphorylase enzymes.
authors.affiliation: Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow, India.
authors.forename: Preeti
authors.initials: P
authors.lastname: Rawat
authors.forename: Mohammad F
authors.initials: MF
authors.lastname: Khan
authors.forename: Manmeet
authors.initials: M
authors.lastname: Kumar
authors.forename: Akhilesh K
authors.initials: AK
authors.lastname: Tamarkar
authors.forename: Arvind K
authors.initials: AK
authors.lastname: Srivastava
authors.forename: Kamal R
authors.initials: KR
authors.lastname: Arya
authors.forename: Rakesh
authors.initials: R
authors.lastname: Maurya
mesh_terms: D045784:Abietanes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D029781:Cupressus / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D005638:Fruit; D005952:Glucose-6-Phosphatase / Q000037:antagonists & inhibitors*; D024981:Glycogen Phosphorylase / Q000037:antagonists & inhibitors*; D006027:Glycosides / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D010636:Phenols / Q000302:isolation & purification / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology; D018515:Plant Leaves
chemical_list: C551159:15-acetoxyimbricatolic acid; D045784:Abietanes; D004224:Diterpenes; D004791:Enzyme Inhibitors; D006027:Glycosides; D010636:Phenols; D010936:Plant Extracts; C431074:ferruginol; D024981:Glycogen Phosphorylase; D005952:Glucose-6-Phosphatase