title: Controlled detection in composite nanoresonant array for surface plasmon resonance sensing.
abstract: A composite nanoresonant structure is developed for sensitivity enhancement in biorecognition reactions by coupling between the localized resonance and the propagating surface plasmon polariton waves. The resonant structure was accomplished by combining holographic lithography with an oblique metallic deposition for cost-effective, large-area, and reconfigurable fabrication. The metallodielectric nanostructure was assembled with microfluidic channels and examined for biorecognition reactions, which showed pronounced improvement in the limit of detection compared to conventional nanohole array sensing configurations. The temperature influence on the binding affinity and the effectiveness of the control channel were also investigated to demonstrate the capability of the proposed composite nanoresonant surface plasmon resonance array sensor.
authors.affiliation: Department of Electrical of Computer Engineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. lpang@ece.ucsd.edu
authors.forename: Lin
authors.initials: L
authors.lastname: Pang
authors.forename: Haiping M
authors.initials: HM
authors.lastname: Chen
authors.forename: Lilin
authors.initials: L
authors.lastname: Wang
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Beechem
authors.forename: Yeshaiahu
authors.initials: Y
authors.lastname: Fainman
mesh_terms: D000818:Animals; D015374:Biosensing Techniques; D019921:Biotinylation; D002417:Cattle; D003362:Cost-Benefit Analysis; D004867:Equipment Design; D020342:Finite Element Analysis; D006696:Holography / Q000379:methods; D008670:Metals / Q000737:chemistry; D046210:Microfluidic Analytical Techniques / Q000379:methods; D053761:Nanocomposites / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D012031:Refractometry; D020349:Surface Plasmon Resonance / Q000379:methods*; D014867:Water / Q000737:chemistry
chemical_list: D008670:Metals; D014867:Water