Lasting reduction of postsurgical hyperalgesia after single injection of botulinum toxin type A in rat.
A single injection of low doses of botulinum toxin type A (3.5 U/kg) completely abolished secondary mechanical hyperalgesia throughout its duration in a model of post surgical pain after gastrocnemius incision in rat.
Filipović
Boris
B
Laboratory of Molecular Neuropharmacology, Department of Pharmacology and Croatian Brain Research Institute, University of Zagreb School of Medicine, Zagreb, Croatia.
Bach-Rojecky
Lidija
L
Lacković
Zdravko
Z
D000818:Animals; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage / Q000627:therapeutic use*; D004195:Disease Models, Animal; D006930:Hyperalgesia / Q000188:drug therapy*; D007279:Injections, Subcutaneous; D008297:Male; D009465:Neuromuscular Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D010149:Postoperative Pain / Q000188:drug therapy*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A