Captopril and 6-mercaptopurine: whose SH possesses higher antioxidant ability?
Antioxidant capacities of captopril (CAP), 6-mercaptopurine (6-MP) and 9-(beta-D-ribofuranosyl)-6-mercaptopurine (6-MPR) were investigated by interacting them with 2,2'-diphenyl-1-picrylhydrazyl (DPPH), galvinoxyl radical, and 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonate) cation radical (ABTS(+)(*)), and by protecting DNA and erythrocyte against 2,2'-azobis(2-amidinopropane hydrochloride) (AAPH) induced oxidation. It was found that CAP possessed the highest ability to donate the hydrogen atom in -SH to DPPH and galvinoxyl, while 6-MPR had the strongest ability to reduce ABTS(+)(*). In the process of protecting DNA and erythrocytes against AAPH-induced oxidation, CAP can trap 0.5 and 1.3 radicals, 6-MP can trap 0.6 and 2.2, and 6-MPR can trap 1.0 and 3.0 radicals, respectively. CAP can also protect erythrocytes against hemin-induced hemolysis.
Li
Guo-Xiang
GX
Department of Organic Chemistry, College of Chemistry, Jilin University, No. 2519 Jiefang Road, Changchun 130021, China.
Liu
Zai-Qun
ZQ
D000975:Antioxidants / Q000494:pharmacology*; D002216:Captopril / Q000737:chemistry* / Q000494:pharmacology*; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism; D016166:Free Radical Scavengers / Q000494:pharmacology*; D006427:Hemin / Q000737:chemistry; D006461:Hemolysis / Q000187:drug effects*; D006801:Humans; D015122:Mercaptopurine / Q000737:chemistry* / Q000494:pharmacology; D015394:Molecular Structure; D013438:Sulfhydryl Compounds / Q000737:chemistry
D000975:Antioxidants; D016166:Free Radical Scavengers; D013438:Sulfhydryl Compounds; D006427:Hemin; D002216:Captopril; D015122:Mercaptopurine