Stress-related modulation of inflammation in experimental models of bowel disease and post-infectious irritable bowel syndrome: role of corticotropin-releasing factor receptors.
The interaction between gut inflammatory processes and stress is gaining increasing recognition. Corticotropin-releasing factor (CRF)-receptor activation in the brain is well established as a key signaling pathway initiating the various components of the stress response including in the viscera. In addition, a local CRF signaling system has been recently established in the gut. This review summarize the present knowledge on mechanisms through which both brain and gut CRF receptors modulate intestinal inflammatory processes and its relevance towards increased inflammatory bowel disease (IBD) activity and post-infectious irritable bowel syndrome (IBS) susceptibility induced by stress.
Kiank
Cornelia
C
David Geffen School of Medicine at UCLA, CURE: Digestive Diseases Research Center-Animal Core, VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA. ckiank@mednet.ucla.edu
Taché
Yvette
Y
Larauche
Muriel
M
D000818:Animals; D006801:Humans; D007249:Inflammation / Q000473:pathology*; D015212:Inflammatory Bowel Diseases / Q000473:pathology*; D043183:Irritable Bowel Syndrome / Q000473:pathology*; D018019:Receptors, Corticotropin-Releasing Hormone / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D013315:Stress, Psychological / Q000473:pathology*
D018019:Receptors, Corticotropin-Releasing Hormone
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