title: Peginterferon (PEG-IFN) plus ribavirin combination therapy, but neither interferon nor PGE-IFN alone, induced type 1 diabetes in a patient with chronic hepatitis C.
abstract: Interferon (IFN) therapies, including IFN, peginterferon (PEG-IFN) and ribavirin (RBV) plus PEG-IFN combination, are widely used for patients with chronic hepatitis C. We encountered a patient with chronic hepatitis C in whom previous IFN or PEG-IFN alone had not induced type 1 diabetes (T1D), while the addition of RBV to PEG-IFN did induce T1D. The patient had HLA types conferring highly susceptibility to T1D. Thus, adding RBV to PEG-IFN may render chronic hepatitis C patients, with T1D-susceptible HLA types, more prone to developing T1D than IFN or PEG-IFN alone. To prevent T1D development, we recommend HLA typing prior to initiating RBV plus PEG-IFN administration.
authors.affiliation: Department of Diabetes and Metabolism, Tohoku University Hospital, Sendai.
authors.forename: Takehide
authors.initials: T
authors.lastname: Ogihara
authors.forename: Hideki
authors.initials: H
authors.lastname: Katagiri
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Yamada
authors.forename: Hirohito
authors.initials: H
authors.lastname: Kudo
authors.forename: Junta
authors.initials: J
authors.lastname: Imai
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Ishigaki
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Hinokio
authors.forename: Yoko
authors.initials: Y
authors.lastname: Yamagiwa
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Ueno
authors.forename: Tooru
authors.initials: T
authors.lastname: Shimosegawa
authors.forename: Yoshitomo
authors.initials: Y
authors.lastname: Oka
mesh_terms: D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000139:chemically induced; D004359:Drug Therapy, Combination; D005260:Female; D019698:Hepatitis C, Chronic / Q000097:blood* / Q000188:drug therapy; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000008:administration & dosage* / Q000009:adverse effects; D008875:Middle Aged; D011092:Polyethylene Glycols / Q000008:administration & dosage* / Q000009:adverse effects; D011994:Recombinant Proteins; D012254:Ribavirin / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D001786:Blood Glucose; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D011092:Polyethylene Glycols; D012254:Ribavirin; C100416:peginterferon alfa-2a