title: Successful topical treatment of sorafenib-induced hand-foot skin reaction in a child with hepatocellular carcinoma.
abstract: Orally active kinase inhibitors such as Sorafenib are known to elicit cutaneous side effects in the majority of adult patients, whereas specific cutaneous complications of this agent have not been described in children so far. We here present the first pediatric case of Sorafenib-induced hand-foot-skin reaction and its successful topical therapy facilitating continuation of kinase inhibitor treatment.
authors.affiliation: Department of Pediatrics and Adolescent Medicine, RWTH Aachen University Hospital, Aachen, Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Hütten
authors.forename: Lisa
authors.initials: L
authors.lastname: Lassay
authors.forename: Bernhardt
authors.initials: B
authors.lastname: Sachs
authors.forename: Peter
authors.initials: P
authors.lastname: Deutz
authors.forename: Roland
authors.initials: R
authors.lastname: Mertens
authors.forename: Jens Malte
authors.initials: JM
authors.lastname: Baron
authors.forename: Hans-Friedrich
authors.initials: HF
authors.lastname: Merk
authors.forename: Hagen
authors.initials: H
authors.lastname: Ott
mesh_terms: D000293:Adolescent; D000970:Antineoplastic Agents / Q000009:adverse effects*; D001557:Benzenesulfonates / Q000009:adverse effects*; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy*; D005533:Foot Dermatoses / Q000139:chemically induced* / Q000188:drug therapy; D006229:Hand Dermatoses / Q000139:chemically induced* / Q000188:drug therapy; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy*; D008297:Male; D009536:Niacinamide / Q000031:analogs & derivatives; D010671:Phenylurea Compounds; D047428:Protein Kinase Inhibitors / Q000009:adverse effects*; D011725:Pyridines / Q000009:adverse effects*; D000077157:Sorafenib
chemical_list: D000970:Antineoplastic Agents; D001557:Benzenesulfonates; D010671:Phenylurea Compounds; D047428:Protein Kinase Inhibitors; D011725:Pyridines; D009536:Niacinamide; D000077157:Sorafenib