Effect of food restriction on adipose tissue in spontaneously diabetic Torii fatty rats.
Spontaneously Diabetic Torii-fa/fa (SDT fatty) rat is a new model of obese type 2 diabetes. SDT fatty rat exhibits obesity associated with hyperphagia. In this study, SDT fatty rats were subjected to pair-feeding with SDT-+/+ (SDT) rats from 6 to 22 weeks of age. The ratio of visceral fat weight to subcutaneous fat weight (V/S) decreased at 12 weeks of age in the pair-feeding rats. The intraperitoneal fat weight such as epididymal and retroperitoneal fat weight decreased, whereas mesenteric fat weight had no change. Cell size of the epididymal fat in the pair-feeding rats tended to decrease. Glucose oxidation level in epididymal fat in the pair-feeding rats at 12 weeks of age was recovered to a similar level with that in SDT rats. These results indicated that SDT fatty rat is a useful model to evaluate the functional or the morphological features in adipose tissue and develop a novel drug for antiobesity.
Morinaga
Hisayo
H
Japan Tobacco Inc., Central Pharmaceutical Research Institute, 1-1, Murasaki-cho, Takatsuki, Osaka 569-1125, Japan. hisayo.morinaga@jt.com
Ohta
Takeshi
T
Matsui
Kenichi
K
Sasase
Tomohiko
T
Fukuda
Sumiaki
S
Ito
Makoto
M
Ueda
Masatoshi
M
Ishii
Yukihito
Y
Miyajima
Katsuhiro
K
Matsushita
Mutsuyoshi
M
D000123:Acetyltransferases / Q000235:genetics; D017667:Adipocytes / Q000473:pathology; D000273:Adipose Tissue / Q000378:metabolism / Q000473:pathology*; D000818:Animals; D001483:Base Sequence; D031204:Caloric Restriction; D048429:Cell Size; D017931:DNA Primers / Q000235:genetics; D003924:Diabetes Mellitus, Type 2 / Q000178:diet therapy* / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D004195:Disease Models, Animal; D005947:Glucose / Q000378:metabolism; D051275:Glucose Transporter Type 4 / Q000235:genetics; D008071:Lipoprotein Lipase / Q000235:genetics; D008297:Male; D009765:Obesity / Q000178:diet therapy* / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D010084:Oxidation-Reduction; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051381:Rats; D011922:Rats, Mutant Strains; D011924:Rats, Zucker; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics
D017931:DNA Primers; D051275:Glucose Transporter Type 4; D012333:RNA, Messenger; C495694:Slc2a4 protein, rat; D014409:Tumor Necrosis Factor-alpha; D000123:Acetyltransferases; C055210:aminoglycoside N1-acetyltransferase; D008071:Lipoprotein Lipase; D005947:Glucose
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