Cancer Cells Expressing Toll-like Receptors and the Tumor Microenvironment.
Toll-like receptors (TLRs) play a crucial role in the innate immune response and the subsequent induction of adaptive immune responses against microbial infection or tissue injury. Recent findings show that functional TLRs are expressed not only on immune cells but also on cancer cells. TLRs play an active role in carcinogenesis and tumor progression during chronic inflammation that involves the tumor microenvironment. Damage-associated molecular patterns (DAMPs) derived from injured normal epithelial cells and necrotic cancer cells appear to be present at significant levels in the tumor microenvironment, and their stimulation of specific TLRs can foster chronic inflammation. This review discusses how carcinogenesis, cancer progression, and site-specific metastasis are related to interactions between cancer cells, immune cells, and DAMPs through TLR activation in the tumor microenvironment.
Sato
Yusuke
Y
Department of Molecular Oncology, John Wayne Cancer Institute at Saint John's Health Center, 2200 Santa Monica Blvd., Santa Monica, CA, 90404, USA.
Goto
Yasufumi
Y
Narita
Norihiko
N
Hoon
Dave S B
DS
Clin Cancer Res. 2007 Dec 1;13(23):7119-25
18056192
PLoS Med. 2009 Jan 13;6(1):e10
19143470
Immunology. 2005 Aug;115(4):565-74
16011525
Cell Cycle. 2009 Feb 15;8(4):589-95
19182519
Gastroenterology. 2008 Aug;135(2):518-28
18538140
Int J Immunopharmacol. 1999 Jan;21(1):1-14
10411278
Nat Rev Cancer. 2005 Apr;5(4):263-74
15776005
Methods Mol Biol. 2006;336:123-34
16916258
Prostate. 2008 Feb 1;68(2):223-9
18092352
Int J Gynecol Cancer. 2008 Mar-Apr;18(2):300-5
17587322
Gastroenterology. 2007 Dec;133(6):1869-81
18054559
Int J Cancer. 2007 Oct 1;121(7):1433-44
17565747
Angiogenesis. 2008;11(1):91-9
18264787
Br J Cancer. 2005 Jun 6;92(11):1955-8
15900299
J Immunol. 2009 Feb 1;182(3):1469-80
19155494
Clin Cancer Res. 2008 Sep 1;14(17):5512-8
18765543
Nat Rev Cancer. 2009 Jan;9(1):57-63
19052556
Immunol Rev. 2008 Apr;222:180-91
18364002
Eur J Cancer. 2008 Sep;44(13):1875-82
18617393
J Biol Chem. 2004 Mar 26;279(13):12542-50
14729660
Cancer Res. 2006 Apr 1;66(7):3859-68
16585214
Clin Cancer Res. 2007 May 15;13(10):2836-48
17504981
Oncogene. 2008 Oct 6;27(45):5904-12
18836471
Int J Oncol. 2008 Nov;33(5):929-36
18949355
Int J Dermatol. 2005 Jan;44(1):14-9
15663652
Mol Cancer Res. 2006 Jul;4(7):437-47
16849519
Biol Pharm Bull. 2005 May;28(5):886-92
15863899
Cancer Immunol Immunother. 2009 Sep;58(9):1375-85
19184006
Cancer Res. 2003 Jul 15;63(14):3966-8
12873992
Science. 2004 Feb 6;303(5659):848-51
14764882
BMC Cancer. 2006 Dec 08;6:281
17156435
Oncogene. 2008 Jan 7;27(2):161-7
18176597
Front Biosci. 2008 Jan 01;13:453-61
17981560
Nature. 2008 Jul 24;454(7203):436-44
18650914
Br J Cancer. 2007 Sep 3;97(5):598-604
17667928
J Intern Med. 2000 Sep;248(3):171-83
10971784
Mol Cancer Ther. 2008 Nov;7(11):3642-53
19001446
Clin Cancer Res. 2006 Jan 15;12(2):577-83
16428503
BMC Immunol. 2008 Jul 24;9:39
18652679
Cancer Biol Ther. 2007 Nov;6(11):1704-9
17986857
Clin Cancer Res. 2007 Aug 1;13(15 Pt 1):4565-74
17671143
Biochem Biophys Res Commun. 2009 Feb 20;379(4):1027-32
19141294
Respir Res. 2005 Jan 04;6:1
15631627
Mol Med. 2008 Sep-Oct;14(9-10):645-59
18584047
Clin Cancer Res. 2008 May 15;14(10):2909-17
18483357
J Cell Biochem. 2007 Jul 1;101(4):805-15
17226777
Clin Cancer Res. 2008 Feb 1;14(3):856-64
18245549
Cancer Cell. 2004 Sep;6(3):297-305
15380520
Blood. 2003 Sep 1;102(5):1740-2
12714497
Clin Chem. 2002 Aug;48(8):1212-7
12142376
Pancreas. 1998 Jul;17(1):89-97
9667526
Oncology. 2005;69 Suppl 3:4-10
16301830
Cancer Res. 2005 Jan 15;65(2):465-72
15695388
J Clin Oncol. 2005 Dec 20;23(36):9351-8
16361635
J Drugs Dermatol. 2005 Nov-Dec;4(6):708-17
16302556
Br J Cancer. 2004 Mar 22;90(6):1211-5
15026803
Immunity. 2008 Jul 18;29(1):12-20
18631453
Int J Med Microbiol. 2005 Jun;295(3):179-85
16044857
J Drugs Dermatol. 2008 Jan;7(1 Suppl 1):s7-14
18277457
Immunol Rev. 2007 Dec;220:60-81
17979840
Nat Cell Biol. 2008 Nov;10(11):1349-55
18820689
Nature. 2004 Sep 23;431(7007):461-6
15329734
Eur Arch Otorhinolaryngol. 2007 May;264(5):525-30
17165086
Immunol Res. 2005;32(1-3):155-68
16106066
Mol Carcinog. 2007 Nov;46(11):941-7
17440926
Prostate. 2007 May 15;67(7):774-81
17373717
Mol Immunol. 2007 Apr;44(11):2850-9
17328955
Cancer Immunol Immunother. 1989;29(2):133-8
2720706
Immunol Rev. 2008 Apr;222:162-79
18364001
Biochem Soc Trans. 2007 Dec;35(Pt 6):1473-8
18031248
J Infect Chemother. 2008 Apr;14(2):86-92
18622669
J Biol Chem. 2004 Feb 13;279(7):5405-12
14645242
J Immunol. 2009 Jan 1;182(1):240-9
19109155
J Immunol. 2005 Dec 15;175(12):8242-52
16339564