title: Probabilistic atlas can improve reconstruction from optical imaging of the neonatal brain.
abstract: Diffuse optical imaging is an emerging medical imaging modality based on near-infrared and visible red light. The method can be used for imaging activations in the human brain. In this study, a deformable probabilistic atlas of the distribution of tissue types within the term neonatal head was created based on MR images. The use of anatomical prior information provided by such atlas in reconstructing brain activations from optical imaging measurements was studied using Monte Carlo simulations. The results suggest that use of generic anatomical information can greatly improve the spatial accuracy and robustness of the reconstruction when noise is present in the data.
authors.affiliation: BioMag Laboratory, HUSLAB, Helsinki University Central Hospital, PO Box 340, FI-00029 HUS, Finland. Juha.Heiskala@iki.fi
authors.forename: Juha
authors.initials: J
authors.lastname: Heiskala
authors.forename: Mika
authors.initials: M
authors.lastname: Pollari
authors.forename: Marjo
authors.initials: M
authors.lastname: Metsäranta
authors.forename: P Ellen
authors.initials: PE
authors.lastname: Grant
authors.forename: Ilkka
authors.initials: I
authors.lastname: Nissilä
mesh_terms: D000465:Algorithms; D001921:Brain / Q000033:anatomy & histology* / Q000473:pathology*; D001931:Brain Mapping / Q000379:methods; D003952:Diagnostic Imaging / Q000295:instrumentation / Q000379:methods; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D007091:Image Processing, Computer-Assisted; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*; D009010:Monte Carlo Method; D055095:Optics and Photonics; D010363:Pattern Recognition, Automated / Q000379:methods; D017785:Photons; D011336:Probability