The effect of regular exercise on quality of life among breast cancer survivors.
The authors evaluated the effect of regular exercise during the first 36 months after cancer diagnosis on quality of life (QOL) in a population-based cohort study of 1,829 Chinese women diagnosed with breast cancer. The women were identified between 2002 and 2004 and were invited to participate in the study about 6 months after cancer diagnosis. Exercise was assessed approximately 6, 18, and 36 months after diagnosis, and a metabolic equivalent task (MET) score in hours per week was derived. A cumulative, weighted exercise-MET score was created for regular exercise during the 36-month postdiagnosis period. QOL was evaluated at 6 and 36 months postdiagnosis. Multiple linear regression and mixed models were conducted to evaluate the association between regular exercise and QOL, with adjustment for clinical prognostic factors and other potential confounders. Both exercise-MET scores measured during the first 6 or 36 months postdiagnosis and the weighted exercise-MET score over the 36-month postdiagnosis period were positively associated with total QOL score and physical, psychological, and social well-being scores assessed at 36 months postdiagnosis (all P for trend < 0.05). Compared with nonregular exercisers, women with higher exercise-MET scores (> or =8.3 MET-hours/week) were more likely to have higher scores for total QOL and specific QOL domains (all P < 0.05). The exercise-QOL association remained stable over time after cancer diagnosis. This study suggests that regular exercise after breast cancer diagnosis improves QOL.
Chen
Xiaoli
X
Vanderbilt Epidemiology Center, Nashville, TN 37203-1738, USA.
Zheng
Ying
Y
Zheng
Wei
W
Gu
Kai
K
Chen
Zhi
Z
Lu
Wei
W
Shu
Xiao Ou
XO
D000223:Adaptation, Psychological; D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000534:rehabilitation*; D016022:Case-Control Studies; D002681:China; D015444:Exercise; D005260:Female; D006304:Health Status; D006801:Humans; D016014:Linear Models; D008875:Middle Aged; D015999:Multivariate Analysis; D011788:Quality of Life; D017741:Survivors
Exerc Sport Sci Rev. 2001 Apr;29(2):60-4
11337824
J Cancer Surviv. 2007 Jun;1(2):116-28
18648952
Qual Life Res. 2005 Mar;14(2):361-71
15892425
J Clin Epidemiol. 2006 Mar;59(3):274-80
16488358
J Clin Oncol. 2008 May 1;26(13):2198-204
18445845
Int J Behav Nutr Phys Act. 2007 Dec 17;4:65
18081938
Cancer Epidemiol Biomarkers Prev. 2009 Feb;18(2):656-63
19190157
Oncol Nurs Forum. 1991 May-Jun;18(4):751-7
2067964
J Clin Oncol. 2001 Feb 1;19(3):657-65
11157015
Breast Cancer Res Treat. 2007 Apr;102(2):201-10
16850242
N Engl J Med. 2001 Jun 28;344(26):1997-2008
11430330
Am J Epidemiol. 2003 Dec 1;158(11):1114-22
14630608
Br J Cancer. 2008 Jul 8;99(1):30-6
18577993
Psychooncology. 2003 Jun;12(4):357-74
12748973
Behav Med. 1998 Winter;23(4):149-59
9494692
Breast J. 2009 Jan-Feb;15(1):45-51
19120381
Breast Cancer Res Treat. 2009 Mar;114(2):357-69
18409069
J Exp Clin Cancer Res. 2008 Aug 29;27:32
18759983
Psychooncology. 2007 Dec;16(12):1059-68
17549801
Psychooncology. 2009 Apr;18(4):343-52
19242918
J Clin Oncol. 2000 Feb;18(4):743-53
10673515
Int J Med Sci. 2008 Jan 15;5(1):24-8
18219372
Prev Med. 2003 Nov;37(5):389-95
14572423
J Clin Oncol. 2007 Jun 10;25(17):2352-9
17557948
Oncol Nurs Forum. 2001 Nov-Dec;28(10):1617-21
11759309
Cancer. 2007 Oct 15;110(8):1851-9
17847016
Med Sci Sports Exerc. 1993 Jan;25(1):71-80
8292105
J Clin Oncol. 2003 May 1;21(9):1660-8
12721239
Psychooncology. 2002 Sep-Oct;11(5):389-400
12228872
CA Cancer J Clin. 2008 Mar-Apr;58(2):71-96
18287387
J Clin Oncol. 2007 Oct 1;25(28):4396-404
17785708
Psychooncology. 2006 Oct;15(10):891-7
16374892
CMAJ. 2006 Jul 4;175(1):34-41
16818906
Yonsei Med J. 2008 Jun 30;49(3):443-50
18581595
Breast J. 2006 Jan-Feb;12 Suppl 1:S70-80
16430400
Psychooncology. 2002 Sep-Oct;11(5):447-56
12228878
Ann Behav Med. 1999 Spring;21(2):171-9
10499138
Breast Cancer Res Treat. 2008 Mar;108(2):279-88
17530428
BMJ. 2007 Mar 10;334(7592):517
17307761