title: Atomic diversity, molecular diversity, and chemical diversity: the concept of chemodiversity.
abstract: This minireview is meant as an introduction to the following paper. To this end, it presents the general background against which the joint paper should be understood. The first objective of the present paper is thus to clarify some concepts and related terminology, drawing a clear distinction between i) atomic diversity (i.e., atomic-property space), ii) molecular or macromolecular diversity (i.e., molecular- or macromolecular-property spaces), and iii) chemical diversity (i.e., chemical-diversity space). The first refers to the various electronic states an atom can occupy. The second encompasses the conformational and property spaces of a given (macro)molecule. The third pertains to the diversity in structure and properties exhibited by a library or a supramolecular assembly of different chemical compounds. The ground is thus laid for the content of the joint paper, which pertains to case ii, to be placed in its broader chemodiversity context. The second objective of this paper is to point to the concepts of chemodiversity and biodiversity as forming a continuum. Chemodiversity is indeed the material substratum of organisms. In other words, chemodiversity is the material condition for life to emerge and exist. Increasing our knowledge of chemodiversity is thus a condition for a better understanding of life as a process.
authors.affiliation: Department of Pharmacy, University Hospital Center (CHUV), Lausanne.
authors.forename: Bernard
authors.initials: B
authors.lastname: Testa
authors.forename: Giulio
authors.initials: G
authors.lastname: Vistoli
authors.forename: Alessandro
authors.initials: A
authors.lastname: Pedretti
authors.forename: Andrzej J
authors.initials: AJ
authors.lastname: Bojarski
mesh_terms: D044822:Biodiversity; D055598:Chemical Phenomena; D003198:Computer Simulation; D007477:Ions / Q000737:chemistry; D046911:Macromolecular Substances / Q000737:chemistry; D008968:Molecular Conformation; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D007477:Ions; D046911:Macromolecular Substances