title: Rhodium-catalyzed highly enantioselective direct intermolecular hydroacylation of 1,1-disubstituted alkenes with unfunctionalized aldehydes.
abstract: We have established that a cationic rhodium(I)/(R,R)-QuinoxP* complex catalyzes the highly enantioselective direct intermolecular hydroacylation of alpha-substituted acrylamides with unfunctionalized aliphatic aldehydes to yield the corresponding gamma-ketoamides in high yields with excellent ee values.
authors.affiliation: Department of Applied Chemistry, Graduate School of Engineering, Tokyo University of Agriculture and Technology, Koganei, Tokyo 184-8588, Japan.
authors.forename: Yu
authors.initials: Y
authors.lastname: Shibata
authors.forename: Ken
authors.initials: K
authors.lastname: Tanaka