Bioactive Nortriterpenoids from Schisandra grandiflora.
Three new nortriterpenoids, schigrandilactones A-C (1-3), along with eight known compounds, were isolated from an organic solvent extract of Schisandra grandiflora. Compounds 1 and 2 feature a spirocyclic moiety in their structures, and compound 3 was characterized with a new oxygenated pattern. The relative configurations of 1 and 3 were determined through single-crystal X-ray experiments. In addition, compounds 1 and 2 displayed cytotoxic activity against two human cancer cell lines, and compound 3 showed anti-HIV-1 inhibition in infected C8166 cells.
Xiao
Wei-Lie
WL
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, People's Republic of China.
Gong
Yan-Qing
YQ
Wang
Rui-Rui
RR
Weng
Zhi-Ying
ZY
Luo
Xiao
X
Li
Xiao-Nian
XN
Yang
Guang-Yu
GY
He
Fei
F
Pu
Jian-Xin
JX
Yang
Liu-Meng
LM
Zheng
Yong-Tang
YT
Lu
Yang
Y
Sun
Han-Dong
HD
D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D008968:Molecular Conformation; D015394:Molecular Structure; D032141:Schisandra / Q000737:chemistry*; D018609:Tibet; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
D019380:Anti-HIV Agents; D004365:Drugs, Chinese Herbal; D014315:Triterpenes; C544366:schigrandilactone A; C544368:schigrandilactone B; C544367:schigrandilactone C