title: [Effectiveness of S-1 plus CPT-11 therapy for an elderly patient with recurrent colon cancer].
abstract: In May 2006, a 79-year-old man underwent left colectomy and D2 lymphadenectomy for descending colon cancer (fStage II , Cur A). No adjuvant chemotherapy was done. Eighteen months after surgery, the serum tumor marker level was increased (CA19-9 526 U/mL), and multiple liver metastases (H2) and peritoneal dissemination were detected using abdominal CT. He was treated with S-1 plus CPT-11 therapy, because mFOLFOX6 as a standard chemotherapy for advanced colorectal cancer was rejected. After 4 courses, tumor markers normalized and abdominal CT revealed a partial response. At present, progression-free survival (PFS) is 240 days. In our case, this regimen was found to be convenient and safe in an outpatient compared with FOLFIRI and FOLFOX. This case suggested that S-1 plus CPT-11 therapy could well be a promising systemic chemotherapy for patients with advanced colorectal cancer.
authors.affiliation: Dept. of Surgery, International University of Health and Welfare Atami Hospital.
authors.forename: Joji
authors.initials: J
authors.lastname: Samejima
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Iwasaki
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Hatori
authors.forename: Masakazu
authors.initials: M
authors.lastname: Kawamoto
authors.forename: Naoki
authors.initials: N
authors.lastname: Gotou
authors.forename: Hiroo
authors.initials: H
authors.lastname: Wada
authors.forename: Norio
authors.initials: N
authors.lastname: Yukawa
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Rino
authors.forename: Toshio
authors.initials: T
authors.lastname: Imada
mesh_terms: D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives; D003082:Colectomy; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000601:surgery; D006801:Humans; D000077146:Irinotecan; D008197:Lymph Node Excision; D008297:Male; D009364:Neoplasm Recurrence, Local; D005641:Tegafur / Q000008:administration & dosage
chemical_list: D000964:Antimetabolites, Antineoplastic; D000972:Antineoplastic Agents, Phytogenic; D005641:Tegafur; D000077146:Irinotecan; D002166:Camptothecin