[Role of thermo TRP channels in cutaneous neurogenic inflammation and itch].
The temperature-sensitive transient receptor potential (TRP) channels, is also called thermo TRP, including TRPV1, TRPV2, TRPV3, TRPV4, TRPM8 and TRPA1, which are expressed in sensory neurons and non-neuronal cells (e.g.keratinocyte, mast cell) of the skin. Thermo TRP channels are activated/sensitized by physical and chemical mediators, which participate in thermosensation and thermoregulation, so that they are key players in pruritus or pain pathogenesis. Thermo TRP channels are also involved in cutaneous neurogenic inflammation, thus they are regarded as molecular targets for future therapy in skin inflammation, pruritus and pain. In addition, following a basic syntax and molecular substrate of nociception and pruriception established by TRP channels-centered concept, the sensory categories can be distinguished and re-defined. Thermo TRP channels should be taken into account when analyzing the pathogenesis and management of itch or pruritic dermatosis.
XIE
Zhi-qiang
ZQ
Department of Dermatology, Peking University Third Hospital, Beijing 100191, China. zhiqx@sohu.com
D006801:Humans; D007249:Inflammation / Q000378:metabolism* / Q000503:physiopathology; D018836:Inflammation Mediators / Q000502:physiology; D011537:Pruritus / Q000378:metabolism*; D011984:Sensory Receptor Cells / Q000378:metabolism; D012867:Skin / Q000294:innervation / Q000378:metabolism*; D013823:Thermoreceptors / Q000378:metabolism; D050051:Transient Receptor Potential Channels / Q000378:metabolism / Q000502:physiology*
D018836:Inflammation Mediators; D050051:Transient Receptor Potential Channels