Association of the herpes simplex virus major tegument structural protein VP22 with chromatin.
The abundant tegument protein VP22 has homologs throughout the alphaherpesvirus family. Numerous groups have been involved in the examination of these homologs, trying to decipher their multiple functions. Investigations early on indicated that VP22 associates with chromatin and further evidence has accumulated in recent years, correlating this protein with chromatin and its components. Ongoing and future studies will determine whether this association with chromatin is specific and whether it serves a function during infection in a physiologically relevant setting.
Ingvarsdottir
Kristin
K
Virology Research Division, Medical Diagnostic Laboratories, LLC, 2439 Kuser Road, Hamilton, NJ 08690-3303, USA.
Blaho
John A
JA
D000595:Amino Acid Sequence; D000818:Animals; D002843:Chromatin / Q000378:metabolism*; D015967:Gene Expression Regulation, Viral; D006801:Humans; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid; D015678:Viral Structural Proteins / Q000378:metabolism*
D002843:Chromatin; D015678:Viral Structural Proteins; C073413:herpes simplex virus type 1 protein VP22