title: Significance and relationship between Yes-associated protein and survivin expression in gastric carcinoma and precancerous lesions.
abstract: OBJECTIVE
  To analyze the differences and relevance of Yes-associated protein (YAP) and survivin, and to explore the correlation and significance of their expression in gastric carcinoma and precancerous lesions.
  
  
  METHODS
  The PV9000 immunohistochemical method was used to detect the expression of YAP and survivin in 98 cases of normal gastric mucosa, 58 intestinal metaplasia (IM), 32 dysplasia and 98 gastric carcinoma.
  
  
  RESULTS
  The positive rates of YAP in dysplasia (37.5%) and gastric carcinoma (48.0%) were significantly higher than that in normal gastric mucosa (13.3%), P < 0.01. The positive rates of survivin in IM (53.4%), dysplasia (59.4%) and gastric carcinoma (65.3%) were significantly higher than in normal gastric mucosa (11.2%), P < 0.01. Survivin expression gradually increased from 41.7% in well differentiated adenocarcinoma through 58.3% in moderately differentiated adenocarcinoma to 75.6% in poorly differentiated adenocarcinoma, with significant Rank correlation, r(k) = 0.279, P < 0.01. The positive rate of survivin in gastric carcinoma of diffused type (74.6%) was significantly higher than that in intestinal type (51.3%), P < 0.05. In gastric carcinoma with lymph node metastasis (76.9%), the positive rate of survivin was significantly higher than that in the group without lymph node metastasis (41.2%), P < 0.01. In 98 cases of gastric carcinoma, the expression of YAP and of survivin were positively correlated, r(k) = 0.246, P < 0.01.
  
  
  CONCLUSIONS
  YAP may play an important role as a carcinogenic factor and may induce survivin expression. Detecting both markers together may help in early diagnosis of gastric carcinoma.
authors.affiliation: The Fourth Laboratory of Cancer Institute, Department of Tumor Pathology of General Surgery Institute, the First Hospital of China Medical University, Shenyang 110001, Liaoning Province, China.
authors.forename: Chun-Li
authors.initials: CL
authors.lastname: Da
authors.forename: Yan
authors.initials: Y
authors.lastname: Xin
authors.forename: Jing
authors.initials: J
authors.lastname: Zhao
authors.forename: Xiang-Dong
authors.initials: XD
authors.lastname: Luo
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D000230:Adenocarcinoma / Q000378:metabolism; D000368:Aged; D017209:Apoptosis; D002277:Carcinoma / Q000378:metabolism*; D005260:Female; D005753:Gastric Mucosa; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins; D007413:Intestinal Mucosa / Q000378:metabolism; D008207:Lymphatic Metastasis; D008297:Male; D008869:Microtubule-Associated Proteins / Q000378:metabolism*; D008875:Middle Aged; D010750:Phosphoproteins / Q000378:metabolism*; D011230:Precancerous Conditions / Q000378:metabolism*; D013274:Stomach Neoplasms / Q000378:metabolism*; D000077022:Survivin; D014157:Transcription Factors; D000091102:YAP-Signaling Proteins
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C107489:BIRC5 protein, human; D051034:Inhibitor of Apoptosis Proteins; D008869:Microtubule-Associated Proteins; D010750:Phosphoproteins; D000077022:Survivin; D014157:Transcription Factors; D000091102:YAP-Signaling Proteins; C088374:YAP1 protein, human
references.citation: Biochem Cell Biol. 2009 Feb;87(1):77-91
references.pmid: 19234525
references.citation: Acta Obstet Gynecol Scand. 2002 Feb;81(2):162-7
references.pmid: 11942908
references.citation: Mol Cell. 2008 Dec 26;32(6):803-14
references.pmid: 19111660
references.citation: Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12405-10
references.pmid: 16894141
references.citation: Int J Gastrointest Cancer. 2006;37(4):103-9
references.pmid: 18175224
references.citation: Biochemistry. 2005 Jan 11;44(1):11-7
references.pmid: 15628841
references.citation: Cell. 2007 Sep 21;130(6):1120-33
references.pmid: 17889654
references.citation: Genes Dev. 2007 Nov 1;21(21):2747-61
references.pmid: 17974916
references.citation: Prostate. 2005 Aug 1;64(3):293-302
references.pmid: 15754318
references.citation: Biochem Biophys Res Commun. 2005 Aug 19;334(1):207-12
references.pmid: 15993841
references.citation: Cell. 2005 Mar 11;120(5):675-85
references.pmid: 15766530
references.citation: Nat Med. 1997 Aug;3(8):917-21
references.pmid: 9256286
references.citation: Cell. 2006 Jan 27;124(2):267-73
references.pmid: 16439203
references.citation: Mol Biol Cell. 2006 Mar;17(3):1483-93
references.pmid: 16407408
references.citation: Nat Genet. 1999 Dec;23(4):387-8
references.pmid: 10581018
references.citation: Oncogene. 1994 Aug;9(8):2145-52
references.pmid: 8035999
references.citation: Biochem Biophys Res Commun. 2009 Jun 19;384(1):114-9
references.pmid: 19393221
references.citation: Mol Cell. 2003 Jan;11(1):11-23
references.pmid: 12535517
references.citation: Mol Cancer Ther. 2006 Sep;5(9):2337-47
references.pmid: 16985068
references.citation: Cell. 2006 Jun 30;125(7):1253-67
references.pmid: 16814713
references.citation: Exp Cell Res. 2002 Apr 15;275(1):44-53
references.pmid: 11925104