Control of alpha-herpesvirus IE gene expression by HCF-1 coupled chromatin modification activities.
The immediate early genes of the alpha-herpesviruses HSV and VZV are transcriptionally regulated by viral and cellular factors in a complex combinatorial manner. Despite this complexity and the apparent redundancy of activators, the expression of the viral IE genes is critically dependent upon the cellular transcriptional coactivator HCF-1. Although the role of HCF-1 had remained elusive, recent studies have demonstrated that the protein is a component of multiple chromatin modification complexes including the Set1/MLL1 histone H3K4 methyltransferases. Studies using model viral promoter-reporter systems as well as analyses of components recruited to the viral genome during the initiation of infection have elucidated the significance of HCF-1 chromatin modification complexes in contributing to the final state of modified histones assembled on the viral IE promoters. Strikingly, the absence of HCF-1 results in the accumulation of nucleosomes bearing repressive marks on the viral IE promoters and silencing of viral gene expression.
Kristie
Thomas M
TM
Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 4-129, 4 Center Drive, Bethesda, Maryland 20892, USA. Thomas_kristie@nih.gov
Liang
Yu
Y
Vogel
Jodi L
JL
D018138:Alphaherpesvirinae / Q000502:physiology*; D002843:Chromatin / Q000378:metabolism*; D019175:DNA Methylation; D015967:Gene Expression Regulation, Viral / Q000502:physiology*; D017781:Genes, Immediate-Early / Q000235:genetics*; D006657:Histones / Q000378:metabolism; D051863:Host Cell Factor C1 / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D014158:Transcription, Genetic
D002843:Chromatin; C497692:HCFC1 protein, human; D006657:Histones; D051863:Host Cell Factor C1
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