Moving forward with nutrition in Alzheimer's disease.
Alzheimer's disease (AD) is the epidemic of the 21st century but still relatively little is known about the causes of the disease. Nutrient deficiencies, associated with loss of cognitive function, are frequently reported in patients with AD and currently available epidemiologic evidence suggests that an increased intake of certain nutrients may lower the risk of AD. Current treatment options offer only symptomatic relief, however, there is a growing body of evidence that nutrition in general and 'nutritional intervention' in a clinical setting may be able to play a key role in the management of the disease. However, randomized clinical trials are needed to test this approach. The Souvenir study is the first randomized, controlled, double-blind, multi-centre study designed to evaluate the efficacy of a multi-nutrient dietary approach on cognitive performance in drug-naïve early AD patients.
Scheltens
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Department of Neurology and Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands. p.scheltens@vumc.nl
D000544:Alzheimer Disease / Q000178:diet therapy* / Q000378:metabolism* / Q000503:physiopathology; D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000627:therapeutic use; D001921:Brain / Q000378:metabolism* / Q000503:physiopathology; D003072:Cognition Disorders / Q000178:diet therapy / Q000378:metabolism / Q000503:physiopathology; D019587:Dietary Supplements / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D008297:Male; D044342:Malnutrition / Q000150:complications / Q000178:diet therapy* / Q000378:metabolism*; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic / Q000706:statistics & numerical data; D014815:Vitamins / Q000378:metabolism / Q000627:therapeutic use
D000975:Antioxidants; D014815:Vitamins