title: Regulation and functional specialization of small RNA-target nodes during plant development.
abstract: The expansion of gene families for miRNA and tasiRNA, small RNA effector proteins (ARGONAUTEs or AGOs), and miRNA/tasiRNA targets has contributed to regulatory diversity in plants. Loss or acquisition of small RNA-generating loci and target site sequences in multigene families represent striking examples of subfunctionalization or neo-functionalization, where regulatory diversity is achieved at the post-transcriptional level. Differential regulation of small RNA and target gene family members, and evolution of unique functionality of distinct small RNA-AGO complexes, provide further regulatory diversity. Here, we focus on the idea of distinct small RNA-target transcript pairs as nodes within biological networks, and review progress toward understanding the role of small RNA-target nodes in the context of auxin signaling.
authors.affiliation: Department of Molecular Biology, Max Planck Institute for Developmental Biology, D-72076 Tuebingen, Germany.
authors.forename: Ignacio
authors.initials: I
authors.lastname: Rubio-Somoza
authors.forename: Joshua T
authors.initials: JT
authors.lastname: Cuperus
authors.forename: Detlef
authors.initials: D
authors.lastname: Weigel
authors.forename: James C
authors.initials: JC
authors.lastname: Carrington
mesh_terms: D018507:Gene Expression Regulation, Developmental; D018506:Gene Expression Regulation, Plant; D007210:Indoleacetic Acids / Q000378:metabolism; D035683:MicroRNAs / Q000378:metabolism*; D005810:Multigene Family; D010944:Plants / Q000235:genetics* / Q000378:metabolism; D018749:RNA, Plant / Q000378:metabolism; D034741:RNA, Small Interfering / Q000378:metabolism*; D014158:Transcription, Genetic
chemical_list: D007210:Indoleacetic Acids; D035683:MicroRNAs; D018749:RNA, Plant; D034741:RNA, Small Interfering