Identification of a novel cytosolic aldehyde dehydrogenase allele, ALDH1A1*4.
This paper reports the identification of a novel cytosolic aldehyde dehydrogenase 1 ( ALDH1A1 ) allele. One hundred and sixty-two Indo-Trinidadian and 85 Afro-Trinidadian individuals were genotyped. A novel ALDH1A1 allele, ALDH1A1*4 , was identified in an Indo-Trinidadian alcoholic with an A inserted at position -554 relative to the translational start site, +1. It was concluded that a wider cross-section of individuals needs to be evaluated in order to determine the representative frequency of the allele, and to see if it is associated with risk of alcoholism.
Moore
Shelley M
SM
Pharmacology Unit, Department of Paraclinical Sciences, Faculty of Medical Sciences, The University of the West Indies, St Augustine, Trinidad and Tobago. smmatrix2k1@yahoo.com
Liang
Tiebing
T
Graves
Tamara J
TJ
McCall
Kevin M
KM
Carr
Lucinda G
LG
Ehlers
Cindy L
CL
D000444:Aldehyde Dehydrogenase / Q000235:genetics*; D000483:Alleles; D001483:Base Sequence; D003600:Cytosol / Q000201:enzymology*; D017931:DNA Primers; D005838:Genotype; D006801:Humans; D016133:Polymerase Chain Reaction; D014300:Trinidad and Tobago
D017931:DNA Primers; D000444:Aldehyde Dehydrogenase
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