title: The Twisted Dwarf's ABC: How Immunophilins Regulate Auxin Transport.
abstract: There is increasing evidence that immunophilins function as key regulators of plant development. One of the best investigated members, the multi-domain FKBP TWISTED DWARF1 (TWD1)/FKBP42, has been shown to reside on both the vacuolar and plasma membranes where it interacts in mirror image with two pairs of ABC transporters, MRP1/ MRP2 and PGP1/PGP19(MDR1), respectively. Twisted dwarf1 and pgp1/pgp19 mutants display strongly overlapping phenotypes, including reduction and disorientation of growth, suggesting functional interaction.In a recent work using plant and heterologous expression systems, TWD1 has been demonstrated to modulate PGP-mediated export of the plant hormone auxin, which controls virtually all plant developmental processes. Here we summarize recent molecular models on TWD1 function in plant development and PGP-mediated auxin tranport and discuss open questions.
authors.affiliation: Zurich-Basel Plant Science Center; University of Zurich; Institute of Plant Biology; Zurich, Switzerland.
authors.forename: Aurélien
authors.initials: A
authors.lastname: Bailly
authors.forename: Valpuri
authors.initials: V
authors.lastname: Sovero
authors.forename: Markus
authors.initials: M
authors.lastname: Geisler
references.citation: J Biomol NMR. 2006 Mar;34(3):197-202
references.pmid: 16604427
references.citation: Plant Physiol. 2004 Apr;134(4):1241-3
references.pmid: 15084722
references.citation: Eur Biophys J. 2007 Apr;36(4-5):393-404
references.pmid: 17033777
references.citation: Cell. 1996 Aug 9;86(3):435-44
references.pmid: 8756725
references.citation: Plant J. 2005 Oct;44(2):179-94
references.pmid: 16212599
references.citation: Curr Med Chem. 2000 Jul;7(7):731-48
references.pmid: 10702636
references.citation: J Biol Chem. 2006 Sep 1;281(35):25475-84
references.pmid: 16803883
references.citation: Plant J. 2002 Nov;32(3):263-76
references.pmid: 12410806
references.citation: Science. 2006 May 12;312(5775):914-8
references.pmid: 16601150
references.citation: Science. 1991 Jan 18;251(4991):283-7
references.pmid: 1702904
references.citation: FEBS Lett. 2001 Apr 20;495(1-2):1-6
references.pmid: 11322937
references.citation: Mol Biol Cell. 2003 Oct;14(10):4238-49
references.pmid: 14517332
references.citation: Methods Enzymol. 1998;290:323-38
references.pmid: 9534173
references.citation: Proc Natl Acad Sci U S A. 2004 Mar 23;101(12):4153-7
references.pmid: 15010530
references.citation: Curr Opin Plant Biol. 2005 Feb;8(1):86-92
references.pmid: 15653405
references.citation: Mol Cell Biol. 1998 May;18(5):3034-43
references.pmid: 9566922
references.citation: Anal Biochem. 2005 Jun 15;341(2):344-51
references.pmid: 15907881
references.citation: J Biol Chem. 1996 Aug 2;271(31):18527-34
references.pmid: 8702500
references.citation: Curr Top Med Chem. 2003;3(12):1315-47
references.pmid: 12871165
references.citation: Nature. 2002 Jun 6;417(6889):618-24
references.pmid: 12050657
references.citation: J Biol Chem. 2001 May 4;276(18):14884-9
references.pmid: 11278753
references.citation: J Biol Chem. 1992 May 15;267(14):9474-7
references.pmid: 1374404
references.citation: Development. 1998 Mar;125(5):909-18
references.pmid: 9449673
references.citation: J Biol Chem. 2006 Oct 13;281(41):30603-12
references.pmid: 16887800
references.citation: Mol Biol Cell. 2004 Jul;15(7):3393-405
references.pmid: 15133126
references.citation: Cancer Chemother Pharmacol. 1999;44(2):152-8
references.pmid: 10412950
references.citation: Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12631-6
references.pmid: 16894144
references.citation: Plant Physiol. 2004 Jan;134(1):101-17
references.pmid: 14730066
references.citation: FEBS Lett. 2006 Jan 9;580(1):251-5
references.pmid: 16364310
references.citation: Cell. 1995 Nov 3;83(3):463-72
references.pmid: 8521476
references.citation: Trends Plant Sci. 2001 Sep;6(9):426-31
references.pmid: 11544132