title: Vitex agnus-castus (Chaste-Tree/Berry) in the treatment of menopause-related complaints.
abstract: BACKGROUND
  The origin of the current practice of administering Vitex agnus-castus in menopause-related complaints is uncertain, but appears to be relatively recent. Here we review the evidence for this application of Vitex based on evidence from pharmacological studies and clinical research.
  
  
  METHODS
  The mechanisms of potential relevance in the context of menopause are explored with reference to the current understanding of the endocrinology and neuroendocrinology of menopause and associated symptoms.
  
  
  CONCLUSIONS
  We conclude that, while evidence from rigorous randomized controlled trials is lacking for the individual herb in this context, emerging pharmacological evidence supports a role for V. agnus-castus in the alleviation of menopausal symptoms and suggests that further investigation may be appropriate.
authors.affiliation: Royal Melbourne Institute of Technology (RMIT) University, Bundoora, Victoria, Australia. diana.vandie@rmit.edu.au
authors.forename: Margaret Diana
authors.initials: MD
authors.lastname: van Die
authors.forename: Henry G
authors.initials: HG
authors.lastname: Burger
authors.forename: Helena J
authors.initials: HJ
authors.lastname: Teede
authors.forename: Kerry M
authors.initials: KM
authors.lastname: Bone
mesh_terms: D005260:Female; D005638:Fruit; D019584:Hot Flashes / Q000188:drug therapy; D006801:Humans; D008593:Menopause / Q000187:drug effects*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic; D020950:Vitex
chemical_list: D010936:Plant Extracts