Fluoride protects boronic acids in the copper(I)-mediated click reaction.
Fluoride has been found to protect boronic acids from copper(i)-mediated decomposition; such findings should be very useful for the preparation of boronic acid-based carbohydrate sensors and boronic acid conjugates using the copper(i)-mediated click reaction.
Jin
Shan
S
Department of Chemistry and Center for Biotechnology and Drug Design, Georgia State University, Atlanta, GA 30302-4098, USA.
Choudhary
Gaurav
G
Cheng
Yunfeng
Y
Dai
Chaofeng
C
Li
Minyong
M
Wang
Binghe
B
D001897:Boronic Acids / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D005459:Fluorides / Q000737:chemistry*; D014230:Triazoles / Q000138:chemical synthesis / Q000737:chemistry
D001897:Boronic Acids; D014230:Triazoles; D003300:Copper; D005459:Fluorides