The reduction of alcohol consumption with novel pharmacological intervention.
The development of pharmacological agents in treating alcoholism represents one of many different ways to suppress alcohol intake. Regarding the hypothetical involvement of different neurochemical systems in "alcohol craving", specific substances have been examined in animals models (especially rats) and increasingly in man. Promising results in reducing "alcohol craving" were described in the use of different kinds of chemical substances. "Craving" therefore can hardly be explained on the basis of a deficit in only one neurochemical (neurotransmitter) system. This conclusion is supported by the data. The efficiacy of many anti-craving substances described in smaller studies must first be confirmed in clinical studies on a wider scale.
Sperling
W
W
Department of Psychiatry, Friedrich Alexander University of Erlangen, Schwabachanlage 6-10, 91054 Erlangen, Germany.
Lesch
O M
OM