title: Antitumor and antimetastatic activities of Rhizoma Paridis saponins.
abstract: Rhizoma Paridis saponins (RPS) have been found to show strong antitumor activity. However, few studies have yet investigated its role on pulmonary metastasis treated with this herb. To investigate the molecular mechanisms related to metastasis, we studied RPS-treated T739 mice using histopathology, immunohistochemistry and reverse transcription polymerase chain reaction. Apoptosis was measured by TUNEL assay. As a result, RPS inhibited tumor growth by inducing apoptosis and upregulated the expression of TIMP-2 and down-regulated the level of MMP-2 and MMP-9. In conclusion, RPS is a potent anticancer agent that elicits programmed cell death and inhibits metastases in murine lung adenocarcinoma in vivo.
authors.affiliation: School of Pharmaceutical Science and Technology, Tianjin University, Weijin Road, Tianjin, China.
authors.forename: Shuli
authors.initials: S
authors.lastname: Man
authors.forename: Wenyuan
authors.initials: W
authors.lastname: Gao
authors.forename: Yanjun
authors.initials: Y
authors.lastname: Zhang
authors.forename: Lulu
authors.initials: L
authors.lastname: Yan
authors.forename: Chaoyi
authors.initials: C
authors.lastname: Ma
authors.forename: Changxiao
authors.initials: C
authors.lastname: Liu
authors.forename: Luqi
authors.initials: L
authors.lastname: Huang
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism / Q000556:secondary*; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D017209:Apoptosis; D029064:Araceae / Q000737:chemistry*; D045744:Cell Line, Tumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology*; D005260:Female; D008175:Lung Neoplasms / Q000378:metabolism / Q000473:pathology*; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism; D061965:Matrix Metalloproteinase Inhibitors; D051379:Mice; D027343:Rhizome / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry / Q000494:pharmacology*; D019716:Tissue Inhibitor of Metalloproteinase-2 / Q000819:agonists / Q000378:metabolism; D023041:Xenograft Model Antitumor Assays
chemical_list: D000970:Antineoplastic Agents; D004365:Drugs, Chinese Herbal; D061965:Matrix Metalloproteinase Inhibitors; D012503:Saponins; D019716:Tissue Inhibitor of Metalloproteinase-2; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9