sRNATarget: a web server for prediction of bacterial sRNA targets.
In bacteria, there exist some small non-coding RNAs (sRNAs) with 40-500 nucleotides in length. Most of them function as posttranscriptional regulation of gene expression through binding to their target mRNAs, in which Hfq protein acts as RNA chaperone. With the increase of identified sRNA genes in the bacterium, prediction of sRNA targets plays a more important role in determining sRNA functions. However, there are few available computational tools for predicting sRNA targets at present. Here we introduced a web server, sRNATarget, for genome-scale prediction of bacterial sRNA targets. The server is based on a recently published model which uses Naive Bayes method as the supervised method and take RNA secondary structure profile as the feature. The prediction results will be returned to the users through E-mail.


BACKGROUND
sRNATarget web server is freely available athttp://ccb.bmi.ac.cn/srnatarget/
Cao
Yuan
Y
Beijing Institute of Basic Medical Sciences, Taiping Road 27, Haidian district, Beijing 100850, China.
Zhao
Yalin
Y
Cha
Lei
L
Ying
Xiaomin
X
Wang
Ligui
L
Shao
Ningsheng
N
Li
Wuju
W
Biochem Biophys Res Commun. 2006 May 12;343(3):950-5
16574072
Curr Opin Microbiol. 2007 Jun;10(3):262-70
17574901
Bioinformatics. 2008 Dec 15;24(24):2849-56
18940824
Nucleic Acids Res. 2006 May 22;34(9):2791-802
16717284
Biochem Biophys Res Commun. 2008 Jul 25;372(2):346-50
18501192
Nucleic Acids Res. 2007;35(3):962-74
17259222
Mol Syst Biol. 2008;4:221
18854820