Malignant fibrous histiocytoma of larynx with giant cell: case report and histological-clinical considerations.
BACKGROUND
Malignant fibrous histiocytoma (MFH) is a tumor which has a mesenchymal origin, and an uncertain histogenesis. MFH with giant cell accounts for 3-15% of all malignant fibrous histiocytomas.


OBJECTIVE
To explore the histopathology, the diagnosis and the treatment of MFH with giant cell of larynx.


METHODS
We report a case of a glottic MFH at a 59-year-old male, who has been smoking for 30 years, and was hospitalized in June 2008 at Emergency County Hospital of Craiova.


RESULTS
The largely-sized tumor was originated in glottic area, upper a left vocal cord, with no paresis. The tumor determined respiratory failure and dysphonia. Patient underwent surgical excision of the tumor after an emergency tracheotomy. The immunohistochemical techniques proved positive for vimentin, smooth muscle actin, CD68, CD34, bcl2, EGFR, S100, Ki67, and negative for CD117, NFT, chromogranin, c-erbB2, CK34betaE12, MNF116, and p53.


CONCLUSIONS
Malignant fibrous histiocytomas (MFH) with giant cell of larynx are very rare mesenchymal neoplasm (this case seems the first reported). The diagnosis of MFH of larynx was difficult and the immunohistochemistry could have been helpful.
Anghelina
Fl
F
ENT Department, University of Medicine and Pharmacy of Craiova, Romania. dr_anghelina_florin@yahoo.com
Ioniţă
Elena
E
Chiuţu
Luminiţa
L
Mogoantă
Carmen Aurelia
CA
Ciolofan
S
S
Iosif
Cristina
C
Ceauşu
M
M
D000199:Actins / Q000378:metabolism; D018952:Antigens, CD34 / Q000378:metabolism; D049109:Cell Proliferation; D066246:ErbB Receptors / Q000378:metabolism; D015726:Giant Cells / Q000378:metabolism / Q000473:pathology*; D051677:Histiocytoma, Malignant Fibrous / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000378:metabolism; D007830:Larynx / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D013194:Staining and Labeling
D000199:Actins; D018952:Antigens, CD34; D019394:Ki-67 Antigen; D066246:ErbB Receptors