title: Application of Snyder-Dolan classification scheme to the selection of "orthogonal" columns for fast screening of illicit drugs and impurity profiling of pharmaceuticals--I. Isocratic elution.
abstract: Fourteen judiciously selected reversed phase columns were tested with 18 cationic drug solutes under the isocratic elution conditions advised in the Snyder-Dolan (S-D) hydrophobic subtraction method of column classification. The standard errors (S.E.) of the least squares regressions of logk' vs. logk'(REF) were obtained for a given column against a reference column and used to compare and classify columns based on their selectivity. The results are consistent with those obtained with a study of the 16 test solutes recommended by Snyder and Dolan. To the extent these drugs are representative, these results show that the S-D classification scheme is also generally applicable to pharmaceuticals under isocratic conditions. That is, those columns judged to be similar based on the 16 S-D solutes were similar based on the 18 drugs; furthermore those columns judged to have significantly different selectivities based on the 16 S-D probes appeared to be quite different for the drugs as well. Given that the S-D method has been used to classify more than 400 different types of reversed phases the extension to cationic drugs is a significant finding.
authors.affiliation: University of Minnesota, Department of Chemistry, 207 Pleasant Street SE, Minneapolis, MN 55455, USA.
authors.forename: Wenzhe
authors.initials: W
authors.lastname: Fan
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Peter W
authors.initials: PW
authors.lastname: Carr
authors.forename: Sarah C
authors.initials: SC
authors.lastname: Rutan
authors.forename: Melanie
authors.initials: M
authors.lastname: Dumarey
authors.forename: Adam P
authors.initials: AP
authors.lastname: Schellinger
authors.forename: Wayne
authors.initials: W
authors.lastname: Pritts
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000295:instrumentation* / Q000379:methods*; D013287:Illicit Drugs / Q000032:analysis*; D004364:Pharmaceutical Preparations / Q000032:analysis*
chemical_list: D013287:Illicit Drugs; D004364:Pharmaceutical Preparations
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