title: Cell-type identity: a key to unlocking the function of neocortical circuits.
abstract: A central tenet of neuroscience is that the precise patterns of connectivity among neurons in a given brain area underlie its function. However, assigning any aspect of perception or behavior to the wiring of local circuits has been challenging. Here, we review recent work in sensory neocortex that demonstrates the power of identifying specific cell types when investigating the functional organization of brain circuits. These studies indicate that knowing the identity of both the presynaptic and postsynaptic cell type is key when analyzing neocortical circuits. Furthermore, identifying the circuit organization of particular cell types in the neocortex allows the recording and manipulation of each cell type's activity and the direct testing of its functional role in perception and behavior.
authors.affiliation: Department of Comparative Medicine, Stanford University, School of Medicine, 300 Pasteur Drive, R314, Stanford, CA 94305-5342, USA.
authors.forename: Solange P
authors.initials: SP
authors.lastname: Brown
authors.forename: Shaul
authors.initials: S
authors.lastname: Hestrin
mesh_terms: D000818:Animals; D009415:Nerve Net / Q000502:physiology*; D009433:Neural Inhibition / Q000502:physiology; D009474:Neurons / Q000502:physiology*; D013003:Somatosensory Cortex / Q000502:physiology*; D013569:Synapses / Q000502:physiology; D009435:Synaptic Transmission / Q000502:physiology
references.citation: Neuron. 2004 Jul 22;43(2):251-9
references.pmid: 15260960
references.citation: Nature. 2009 Feb 26;457(7233):1142-5
references.pmid: 19151697
references.citation: J Neurosci. 2007 Feb 21;27(8):2145-9
references.pmid: 17314309
references.citation: Proc Natl Acad Sci U S A. 2008 Jun 17;105(24):8428-33
references.pmid: 18550841
references.citation: J Neurosci. 2001 Oct 15;21(20):8062-71
references.pmid: 11588179
references.citation: Nature. 1999 Nov 4;402(6757):75-9
references.pmid: 10573419
references.citation: J Neurosci. 2005 Jul 6;25(27):6278-85
references.pmid: 16000617
references.citation: Nature. 2009 Jun 4;459(7247):663-7
references.pmid: 19396156
references.citation: Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12438-43
references.pmid: 12213962
references.citation: Cereb Cortex. 2008 Oct;18(10):2296-305
references.pmid: 18203691
references.citation: Nat Neurosci. 2006 Dec;9(12):1472-3
references.pmid: 17099707
references.citation: J Neurosci. 2006 Apr 19;26(16):4394-405
references.pmid: 16624959
references.citation: J Physiol. 2007 May 15;581(Pt 1):139-54
references.pmid: 17317752
references.citation: Science. 2006 Jan 13;311(5758):233-5
references.pmid: 16410524
references.citation: Nature. 2009 Feb 26;457(7233):1137-41
references.pmid: 19151696
references.citation: Nat Neurosci. 2005 Nov;8(11):1552-9
references.pmid: 16222228
references.citation: Nat Neurosci. 2007 Jun;10(6):743-53
references.pmid: 17515899
references.citation: Nature. 2009 Mar 26;458(7237):501-4
references.pmid: 19204731
references.citation: Cereb Cortex. 1997 Sep;7(6):523-33
references.pmid: 9276177
references.citation: J Neurosci. 2002 Aug 15;22(16):7055-64
references.pmid: 12177202
references.citation: PLoS Biol. 2005 Mar;3(3):e68
references.pmid: 15737062
references.citation: Cereb Cortex. 2008 Feb;18(2):315-30
references.pmid: 17517679
references.citation: Science. 2001 Aug 3;293(5531):868-72
references.pmid: 11486089
references.citation: J Neurophysiol. 2008 Nov;100(5):2640-52
references.pmid: 18799598
references.citation: J Neurophysiol. 2007 Dec;98(6):3330-40
references.pmid: 17898147
references.citation: Neuron. 2003 Jun 5;38(5):805-17
references.pmid: 12797964
references.citation: Nat Neurosci. 2005 Jun;8(6):782-90
references.pmid: 15880111
references.citation: J Neurosci. 2008 Oct 29;28(44):11186-95
references.pmid: 18971461
references.citation: Science. 2003 Mar 21;299(5614):1902-5
references.pmid: 12649485
references.citation: J Physiol. 2003 Aug 15;551(Pt 1):139-53
references.pmid: 12813147
references.citation: J Neurosci. 2004 Oct 27;24(43):9598-611
references.pmid: 15509747
references.citation: Curr Opin Neurobiol. 2008 Dec;18(6):617-23
references.pmid: 19349161
references.citation: Nature. 2009 Feb 26;457(7233):1133-6
references.pmid: 19151698
references.citation: Cereb Cortex. 2007 Sep;17(9):2204-13
references.pmid: 17124287
references.citation: Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16797-802
references.pmid: 18940923
references.citation: Neuron. 2007 Mar 1;53(5):735-46
references.pmid: 17329212
references.citation: Front Neurosci. 2007 Oct 15;1(1):19-42
references.pmid: 18982117
references.citation: Nature. 1999 Nov 4;402(6757):72-5
references.pmid: 10573418
references.citation: Nat Neurosci. 1998 Aug;1(4):279-85
references.pmid: 10195160
references.citation: J Neurosci. 2003 Jan 1;23(1):96-102
references.pmid: 12514205
references.citation: Curr Opin Neurobiol. 2008 Jun;18(3):346-53
references.pmid: 18801435
references.citation: Nat Rev Neurosci. 2008 Jul;9(7):557-68
references.pmid: 18568015
references.citation: Nat Neurosci. 2006 Apr;9(4):534-42
references.pmid: 16547512
references.citation: Science. 2005 May 6;308(5723):863-6
references.pmid: 15774725
references.citation: PLoS Comput Biol. 2009 Mar;5(3):e1000334
references.pmid: 19325892
references.citation: J Neurosci. 2004 Sep 29;24(39):8441-53
references.pmid: 15456817
references.citation: Nature. 2009 Jun 4;459(7247):698-702
references.pmid: 19396159
references.citation: Cereb Cortex. 2009 Jun;19(6):1345-59
references.pmid: 18842664