title: On the origin of event-related potentials indexing covert attentional selection during visual search.
abstract: Despite nearly a century of electrophysiological studies recording extracranially from humans and intracranially from monkeys, the neural generators of nearly all human event-related potentials (ERPs) have not been definitively localized. We recorded an attention-related ERP component, known as the N2pc, simultaneously with intracranial spikes and local field potentials (LFPs) in macaques to test the hypothesis that an attentional-control structure, the frontal eye field (FEF), contributed to the generation of the macaque homologue of the N2pc (m-N2pc). While macaques performed a difficult visual search task, the search target was selected earliest by spikes from single FEF neurons, later by FEF LFPs, and latest by the m-N2pc. This neurochronometric comparison provides an empirical bridge connecting macaque and human experiments and a step toward localizing the neural generator of this important attention-related ERP component.
authors.affiliation: Department of Psychology, Vanderbilt Vision Research Center, Center for Integrative and Cognitive Neuroscience, Vanderbilt Brain Institute, Vanderbilt University, Nashville, Tennessee 37240, USA.
authors.forename: Jeremiah Y
authors.initials: JY
authors.lastname: Cohen
authors.forename: Richard P
authors.initials: RP
authors.lastname: Heitz
authors.forename: Jeffrey D
authors.initials: JD
authors.lastname: Schall
authors.forename: Geoffrey F
authors.initials: GF
authors.lastname: Woodman
mesh_terms: D000200:Action Potentials; D000818:Animals; D001288:Attention / Q000502:physiology*; D004569:Electroencephalography; D005071:Evoked Potentials / Q000502:physiology*; D005625:Frontal Lobe / Q000502:physiology*; D008255:Macaca radiata; D008297:Male; D009474:Neurons / Q000502:physiology*; D009483:Neuropsychological Tests; D011930:Reaction Time; D013647:Task Performance and Analysis; D013997:Time Factors; D014793:Visual Cortex / Q000502:physiology*; D014796:Visual Perception / Q000502:physiology*
references.citation: Brain Res. 1971 Nov;34(1):19-35
references.pmid: 5001429
references.citation: Annu Rev Neurosci. 1995;18:193-222
references.pmid: 7605061
references.citation: Neuron. 2008 Feb 28;57(4):614-25
references.pmid: 18304489
references.citation: Clin Neurophysiol. 2004 Oct;115(10):2195-222
references.pmid: 15351361
references.citation: Electroencephalogr Clin Neurophysiol. 1992 May-Jun;84(3):269-79
references.pmid: 1375886
references.citation: Psychol Sci. 2003 Nov;14(6):605-11
references.pmid: 14629693
references.citation: J Neurosci. 2004 Feb 25;24(8):1822-32
references.pmid: 14985422
references.citation: Cereb Cortex. 2008 Oct;18(10):2410-5
references.pmid: 18326522
references.citation: Electroencephalogr Clin Neurophysiol. 1992 Jul;83(1):87-90
references.pmid: 1376671
references.citation: Brain. 1980 Jun;103(2):221-44
references.pmid: 6772266
references.citation: J Neurosci. 2001 Jan 15;21(2):713-25
references.pmid: 11160450
references.citation: Cereb Cortex. 2007 Feb;17(2):391-9
references.pmid: 16525126
references.citation: Psychol Rev. 2005 Apr;112(2):291-328
references.pmid: 15783288
references.citation: J Clin Neurophysiol. 1997 Nov;14(6):470-83
references.pmid: 9458053
references.citation: Cereb Cortex. 2000 Dec;10(12):1233-41
references.pmid: 11073872
references.citation: Science. 1995 May 12;268(5212):889-93
references.pmid: 7754376
references.citation: J Neurophysiol. 2009 Feb;101(2):912-6
references.pmid: 19052112
references.citation: J Neurol Psychiatry. 1938 Oct;1(4):359-85
references.pmid: 21610936
references.citation: Cereb Cortex. 2001 Apr;11(4):298-311
references.pmid: 11278193
references.citation: J Neurosci Methods. 2008 Mar 30;169(1):141-57
references.pmid: 18242715
references.citation: Biol Psychol. 2002 Sep;60(2-3):173-98
references.pmid: 12270590
references.citation: J Neurophysiol. 1997 Feb;77(2):1046-50
references.pmid: 9065870
references.citation: Neuron. 2006 Jun 1;50(5):791-8
references.pmid: 16731516
references.citation: J Neurophysiol. 1996 Dec;76(6):4040-55
references.pmid: 8985899
references.citation: Neuron. 2003 May 22;38(4):637-48
references.pmid: 12765614
references.citation: Cogn Psychol. 1997 Jun;33(1):64-87
references.pmid: 9212722
references.citation: Psychophysiology. 1994 May;31(3):291-308
references.pmid: 8008793
references.citation: Nature. 1993 Dec 2;366(6454):467-9
references.pmid: 8247155
references.citation: J Exp Psychol Hum Percept Perform. 2003 Feb;29(1):121-38
references.pmid: 12669752
references.citation: J Neurophysiol. 2009 Apr;101(4):1699-704
references.pmid: 19176607
references.citation: J Physiol Paris. 2003 Jul-Nov;97(4-6):613-28
references.pmid: 15242670
references.citation: Isr J Med Sci. 1965 Jan;1:104-17
references.pmid: 14256941
references.citation: Vision Res. 1991;31(7-8):1143-57
references.pmid: 1891808
references.citation: Cereb Cortex. 2000 Apr;10(4):343-58
references.pmid: 10769247
references.citation: Vision Res. 1992 May;32(5):797-807
references.pmid: 1604849
references.citation: Science. 1984 Jan 13;223(4632):186-8
references.pmid: 6691145
references.citation: J Neurophysiol. 1998 Jun;79(6):3272-8
references.pmid: 9636126
references.citation: Biol Psychol. 1980 Nov-Dec;11(3-4):181-91
references.pmid: 7272391
references.citation: Proc Natl Acad Sci U S A. 1998 Feb 3;95(3):781-7
references.pmid: 9448241
references.citation: Psychol Rev. 1989 Jul;96(3):433-58
references.pmid: 2756067
references.citation: Trends Neurosci. 2000 Nov;23(11):571-9
references.pmid: 11074267
references.citation: J Neurosci. 2005 Oct 12;25(41):9479-87
references.pmid: 16221858
references.citation: Science. 2009 May 29;324(5931):1207-10
references.pmid: 19478185
references.citation: J Neurophysiol. 1983 May;49(5):1268-84
references.pmid: 6864250
references.citation: J Neurosci. 1988 Jun;8(6):1831-45
references.pmid: 3385477
references.citation: Cereb Cortex. 2000 Apr;10(4):359-70
references.pmid: 10769248
references.citation: J Physiol. 1934 Jul 31;81(4):440-71
references.pmid: 16994555
references.citation: Proc Natl Acad Sci U S A. 1980 May;77(5):3033-7
references.pmid: 6771765
references.citation: J Exp Psychol Hum Percept Perform. 1994 Oct;20(5):1000-14
references.pmid: 7964526
references.citation: J Neurosci. 2000 May 1;20(9):3263-81
references.pmid: 10777791
references.citation: Electroencephalogr Clin Neurophysiol. 1991 Jan-Feb;80(1):65-72
references.pmid: 1703952
references.citation: Nature. 1999 Aug 26;400(6747):867-9
references.pmid: 10476964
references.citation: Prog Brain Res. 2005;147:251-62
references.pmid: 15581711
references.citation: Electroencephalogr Clin Neurophysiol. 1964 Nov;17:520-3
references.pmid: 14229852
references.citation: J Physiol. 2003 Jul 15;550(Pt 2):529-34
references.pmid: 12807983
references.citation: Electroencephalogr Clin Neurophysiol. 1967 Feb;22(2):159-66
references.pmid: 4163686
references.citation: Cogn Psychol. 1980 Jan;12(1):97-136
references.pmid: 7351125
references.citation: Nature. 1994 Dec 8;372(6506):543-6
references.pmid: 7990926
references.citation: Annu Rev Physiol. 2004;66:735-69
references.pmid: 14977420
references.citation: Neuron. 2001 May;30(2):583-91
references.pmid: 11395016
references.citation: Proc Natl Acad Sci U S A. 2007 Sep 18;104(38):15111-6
references.pmid: 17848520
references.citation: J Neurophysiol. 1985 Mar;53(3):603-35
references.pmid: 3981231
references.citation: J Neurosci. 1992 Dec;12(12):4745-65
references.pmid: 1464765
references.citation: Vision Res. 2004 Jun;44(12):1453-67
references.pmid: 15066404
references.citation: Electroencephalogr Clin Neurophysiol. 1992 May-Jun;84(3):219-31
references.pmid: 1375881
references.citation: Front Neuroanat. 2009 May 22;3:2
references.pmid: 19506705
references.citation: Trends Cogn Sci. 2004 Jul;8(7):315-24
references.pmid: 15242691
references.citation: Neuron. 2009 Jan 15;61(1):35-41
references.pmid: 19146811
references.citation: Electroencephalogr Clin Neurophysiol. 1965 Feb;18:217-28
references.pmid: 14255050