title: Neurohumoral mechanisms in deoxycorticosterone acetate (DOCA)-salt hypertension in rats.
abstract: This brief review describes the role of neural and non-neural mechanisms during different phases of deoxycorticosterone acetate (DOCA)-salt hypertension. There are contradictory data for and against a role of the sympathetic nervous system and neurohumoral agents, including endothelin and vasopressin. Elucidating the factors responsible for DOCA-salt hypertension will be helpful in understanding the causes of hypertension resulting from hypervolaemia, hyperaldosteronism and high salt intake.
authors.affiliation: Department of Pharmacological and Physiological Science, St Louis University School of Medicine, 1402 South Grand Boulevard, St Louis, MO 63104, USA.
authors.forename: Henok
authors.initials: H
authors.lastname: Yemane
authors.forename: Marius
authors.initials: M
authors.lastname: Busauskas
authors.forename: Sarah K
authors.initials: SK
authors.lastname: Burris
authors.forename: Mark M
authors.initials: MM
authors.lastname: Knuepfer
mesh_terms: D000818:Animals; D003900:Desoxycorticosterone / Q000633:toxicity*; D004195:Disease Models, Animal; D006801:Humans; D006973:Hypertension / Q000139:chemically induced* / Q000378:metabolism*; D018377:Neurotransmitter Agents / Q000378:metabolism*; D051381:Rats; D017673:Sodium Chloride, Dietary / Q000009:adverse effects
chemical_list: D018377:Neurotransmitter Agents; D017673:Sodium Chloride, Dietary; D003900:Desoxycorticosterone