Cancer: CINful centrosomes.
The regulation of centrosome number is lost in many tumors and the presence of extra centrosomes correlates with chromosomal instability. Recent work now reveals how extra centrosomes cause chromosome mis-segregation in tumor cells.
Bakhoum
Samuel F
SF
Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755, USA.
Compton
Duane A
DA
D002455:Cell Division; D018385:Centrosome / Q000502:physiology*; D043171:Chromosomal Instability / Q000502:physiology*; D018386:Kinetochores / Q000502:physiology; D008870:Microtubules / Q000502:physiology; D008954:Models, Biological; D009369:Neoplasms / Q000503:physiopathology*
Nature. 2005 Oct 13;437(7061):1043-7
16222300
Nat Cell Biol. 2009 Jan;11(1):27-35
19060894
Dev Cell. 2007 Aug;13(2):190-202
17681131
Nature. 2009 Jul 9;460(7252):278-82
19506557
Proc Natl Acad Sci U S A. 2004 Jun 8;101(23):8699-704
15159543
Nat Rev Cancer. 2002 Nov;2(11):815-25
12415252
Nat Rev Mol Cell Biol. 2007 Jun;8(6):451-63
17505520
J Cell Sci. 2002 Feb 1;115(Pt 3):507-15
11861758
Cell. 2008 Jun 13;133(6):1032-42
18555779
Science. 2008 Oct 31;322(5902):703-9
18974345
Genes Dev. 2008 Aug 15;22(16):2189-203
18662975
Genes Chromosomes Cancer. 2000 Feb;27(2):183-90
10612807
Cancer Cell. 2008 Aug 12;14(2):111-22
18656424
Oncogene. 2002 Sep 9;21(40):6146-53
12214243
Cancer Res. 2001 Mar 1;61(5):2212-9
11280789
J Cell Biol. 2001 Apr 30;153(3):517-27
11331303
Nature. 1998 Dec 17;396(6712):643-9
9872311
Science. 2005 Jan 7;307(5706):127-9
15637283
J Cell Sci. 2003 Oct 15;116(Pt 20):4213-25
12953065
J Cell Biol. 2008 Feb 25;180(4):665-72
18283116