title: Polymorphism in the IL10 promoter region and early markers of atherosclerosis: the Cardiovascular Risk in Young Finns Study.
abstract: OBJECTIVE
  Inflammatory factors modify the risk of coronary heart disease. Pleiotropic cytokine interleukin-10 (IL-10) has been suggested as modifying risk for atherosclerosis. Promoter region genetic polymorphism of IL-10 gene (IL10) is known to be associated with the variation of IL-10 production. We investigated whether single-base exchange polymorphisms -1082 G>A (rs1800896), -819 C>T (rs1800871) and -592 C>A (rs1800872) at IL10 gene are associated with risk factors and early markers of atherosclerosis in young subjects.
  
  
  RESULTS
  As a part of the Cardiovascular Risk in Young Finns Study, we determined carotid artery compliance (CAC), stiffness index (SI) and Young's elastic modulus (YEM), intima media thickness (IMT), IL10 genotype and atherosclerosis risk parameters for 2260 subjects aged 24-39 years. In male subjects CAC was lower in carriers of IL-10 high- to intermediate-producer haplotype -1082 G; -819 C; -592 C (GCC+, 1.96+/-0.67) than in noncarriers (GCC-, 2.10+/-0.62, %/10 mmHg, mean+/-SD, p=0.0010). An inverse association was observed in SI (GCC+, 5.76+/-2.12 and GCC-, 5.26+/-1.46, p=0.0034) and YEM (GCC+, 347+/-165 and GCC-, 305+/-110, mm Hg.mm, p=0.0005). Associations remained significant when adjusted to age, BMI, smoking and serum lipids as well as fasting glucose and insulin levels. The genetic effect size for these parameters was not significant in women.
  
  
  CONCLUSIONS
  IL10 promoter region high- to intermediate-producer haplotype GCC associates with decreased arterial elasticity in men. These results are in disconcordance with the supposed antiatheromatous properties of IL-10.
authors.affiliation: The Medical School at the University of Tampere, Finland.
authors.forename: Miikael
authors.initials: M
authors.lastname: Heiskanen
authors.forename: Mika
authors.initials: M
authors.lastname: Kähönen
authors.forename: Mikko
authors.initials: M
authors.lastname: Hurme
authors.forename: Terho
authors.initials: T
authors.lastname: Lehtimäki
authors.forename: Nina
authors.initials: N
authors.lastname: Mononen
authors.forename: Markus
authors.initials: M
authors.lastname: Juonala
authors.forename: Nina
authors.initials: N
authors.lastname: Hutri-Kähönen
authors.forename: Jorma
authors.initials: J
authors.lastname: Viikari
authors.forename: Olli
authors.initials: O
authors.lastname: Raitakari
authors.forename: Janne
authors.initials: J
authors.lastname: Hulkkonen
mesh_terms: D000328:Adult; D050197:Atherosclerosis / Q000235:genetics*; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic / Q000235:genetics*; D012307:Risk Factors
chemical_list: D005819:Genetic Markers; D016753:Interleukin-10