Association and impact of XPG Asp 1104 His gene polymorphism in HIV 1 disease progression to AIDS among north Indian HIV seropositive individuals.
Various efforts made to stop the deadly epidemic of HIV since its discovery in 1983 remain unsuccessful and this virus still continues to claim the lives of millions of individuals every year. The viral effect in the cell is complicated and the overall disease outcome is the result of interaction between a few viral proteins and complex host immune response. Because it has been reported that XPG (Xeroderma pigementesum group G) gene does play a role in reducing UV induced apoptosis and participate in Nucleotide Excision Repair (NER) process of DNA damage, it was hypothesized that polymorphism in this gene may have a role in HIV 1 disease progression to AIDS. The aim of the present study, therefore, was to find out the association between XPG gene polymorphism and its effect on the rate of HIV 1 disease progression to AIDS. 300 HIV seropositive cases and an equal number of age and sex matched controls were recruited for the study from north Indian population. The PCR-RFLP method was utilized to genotype 600 study subject for the XPG Asp (1104) His gene polymorphism. There was significant difference in the frequency of the His/His variant genotype (OR 1.95, 95% CI = 1.93-3.63, P = 0.04) between cases and controls indicating a probable role of this gene in host viral interactions.
Sobti
Ranbir Chander
RC
Department of Biotechnology, Panjab University, Chandigarh, India. rcsobti@pu.ac.in
Berhane
Nega
N
Mehedi
Salih Abedule
SA
Kler
Rupinder
R
Hosseini
Seyed Ali
SA
Kuttiat
Vijish
V
Wanchu
Ajay
A
D000163:Acquired Immunodeficiency Syndrome / Q000235:genetics* / Q000635:transmission; D000293:Adolescent; D000328:Adult; D019943:Amino Acid Substitution / Q000235:genetics; D001224:Aspartic Acid / Q000235:genetics; D016022:Case-Control Studies; D004268:DNA-Binding Proteins / Q000235:genetics*; D018450:Disease Progression; D004720:Endonucleases / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006679:HIV Seropositivity / Q000235:genetics*; D015497:HIV-1 / Q000502:physiology*; D006639:Histidine / Q000235:genetics; D006801:Humans; D007194:India; D008297:Male; D017533:Marital Status; D008875:Middle Aged; D009687:Nuclear Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D018454:Spouses; D014157:Transcription Factors / Q000235:genetics*; D055815:Young Adult; D000099250:DNA Excision Repair Protein ERCC-5
D001224:Aspartic Acid; D004268:DNA-Binding Proteins; D004720:Endonucleases; D006639:Histidine; D009687:Nuclear Proteins; D014157:Transcription Factors; D000099250:DNA Excision Repair Protein ERCC-5
Biochemistry (Mosc). 2002 Jul;67(7):730-6
12139469
Science. 1992 Jul 10;257(5067):217-9
1352911
Nat Rev Cancer. 2004 Sep;4(9):727-37
15343279
Annu Rev Cell Dev Biol. 1999;15:269-90
10611963
Int J Med Sci. 2007 Feb 01;4(2):59-71
17299578
Science. 1993 May 28;260(5112):1269-70
8098552
J Clin Invest. 1990 Jul;86(1):148-59
2114424
J Gen Virol. 2003 Jul;84(Pt 7):1649-1661
12810858
Nature. 2001 May 17;411(6835):366-74
11357144
Oncogene. 2005 Nov 3;24(48):7135-44
16044158
Genes Dev. 1999 Apr 1;13(7):768-85
10197977
J Immunol. 1996 May 1;156(9):3509-20
8617980
AIDS Rev. 2007 Oct-Dec;9(4):195-207
18219363
J Clin Invest. 1989 Sep;84(3):733-7
2474573
Cancer Epidemiol Biomarkers Prev. 2009 Mar;18(3):987-93
19240242
Mol Cell. 2005 Oct 28;20(2):187-98
16246722
Nat Rev Cancer. 2001 Oct;1(1):22-33
11900249
Nucleic Acids Res. 2001 Apr 1;29(7):1443-52
11266544
Trends Mol Med. 2006 Sep;12(9):440-50
16899408
Immunol Cell Biol. 2000 Dec;78(6):586-95
11114968
Cell Death Differ. 2006 Mar;13(3):478-88
16167068
Oncogene. 1999 Dec 13;18(53):7644-55
10618704
Carcinogenesis. 2003 Oct;24(10):1677-81
12869423
Cell. 2002 Jun 28;109(7):823-34
12110180
Neoplasia. 2008 Mar;10(3):255-65
18320070
AIDS Res Ther. 2007 May 14;4:11
17502001
AIDS. 1989 Nov;3(11):695-9
2515876
Int J Cancer. 2006 Feb 1;118(3):714-20
16094634
Ann Intern Med. 1995 Apr 15;122(8):573-9
7887550
Mol Cell. 1999 Jan;3(1):33-42
10024877
Carcinogenesis. 2004 May;25(5):729-34
14688016
J Pathol. 2008 Jan;214(2):231-41
18161758
Blood. 1990 Dec 1;76(11):2303-10
2257304
J Exp Med. 1992 Feb 1;175(2):331-40
1346269
Nat Med. 1995 Feb;1(2):129-34
7585008
J Virol. 1995 Apr;69(4):2092-2100
7884855
J Zhejiang Univ Sci B. 2007 Jun;8(6):377-97
17565509
AIDS. 1991 Sep;5(9):1139-40
1930778
J Virol. 2001 Apr;75(7):3121-8
11238839