Spatial distribution of long-term potentiation in the surround of visual cortex lesions in vitro.
Focal visual cortex lesions lead to functional changes in the surrounding cortical network, possibly mediated through synaptic long-term potentiation (LTP). Although a post-lesional facilitation of LTP has been observed, nothing is known about the spatial profile of LTP in the normal and focally lesioned visual cortex of rats. We used a 64-multielectrode array to characterise the spread of LTP induced by theta-burst stimulation in layer IV. Measurements were made at comparable distances from the midline in the visual cortex of controls, sham-operated and lesioned animals. In control rats, LTP was elicited in projections to all visual cortex layers. However, we completely failed to observe LTP in sham-operated animals 1-4 days after surgery. At comparable survival times, no LTP could be elicited in the lesion-treated rats in direct vicinity of the border of the injury, while LTP was successfully induced at larger distances from the lesion. The maximal reach of this restored post-lesion LTP was spatially more limited than in controls and equal in all directions, accordingly absolute distance and not maximal length or density of connections seems to rule local lesion-induced functional remodelling.
Dohle
Carolin I
CI
Department of Neurology, Yale School of Medicine, New Haven, CT 06520, USA.
Eysel
Ulf T
UT
Mittmann
Thomas
T
D000818:Animals; D017774:Long-Term Potentiation / Q000502:physiology*; D009415:Nerve Net / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D014793:Visual Cortex / Q000502:physiology*
J Neurosci. 2007 Sep 5;27(36):9648-52
17804625
Proc Natl Acad Sci U S A. 2006 Jul 11;103(28):10805-10
16818873
Science. 1990 Apr 13;248(4952):229-31
2326637
Cereb Cortex. 1996 Nov-Dec;6(6):751-8
8922331
J Neurosci. 1994 Mar;14(3 Pt 2):1634-45
8126560
Brain Res. 2003 Nov 14;990(1-2):120-8
14568336
Nat Neurosci. 2008 Oct;11(10):1162-7
18758460
Cereb Cortex. 1999 Mar;9(2):101-9
10220223
J Neurosci Res. 2006 May 1;83(6):1141-50
16498613
J Neurochem. 1983 May;40(5):1497-9
6300337
J Physiol. 2004 Sep 15;559(Pt 3):875-82
15284339
Neuroscience. 1999;93(4):1233-40
10501447
Eur J Neurosci. 2002 May;15(10):1641-5
12059971
Brain Res Dev Brain Res. 1990 Jul 1;54(2):287-90
1975777
J Neurosci. 2007 Apr 11;27(15):4101-9
17428988
J Physiol. 1989 Jul;414:125-44
2575160
Adv Neurol. 1997;73:195-206
8959215
J Toxicol Environ Health A. 1998 Jun 12;54(3):209-26
9643873
Brain Res. 1987 Mar 3;405(1):100-7
3567587
Eur J Neurosci. 2000 Jan;12(1):264-72
10651881
Adv Neurol. 1997;73:207-27
8959216
Restor Neurol Neurosci. 1999;15(2-3):153-64
12671230
Neuroscience. 2002;112(1):195-215
12044484
Ann Neurol. 1998 Aug;44(2):255-8
9708549
Muscle Nerve. 2001 Aug;24(8):1000-19
11439375
Nature. 1994 Apr 21;368(6473):737-40
8152484
Neuroreport. 2001 Oct 8;12(14):3023-8
11568630
Physiol Behav. 1994 Jun;55(6):1141-6
8047583
J Comp Neurol. 1989 Jan 8;279(2):171-86
2913064
Neuroreport. 2001 Oct 29;12(15):3341-7
11711883
Neuroreport. 2000 Dec 18;11(18):4021-5
11192622
J Neurophysiol. 1992 Apr;67(4):841-51
1350308
J Physiol. 1993 Feb;461:247-62
8350264
Nat Neurosci. 1998 Jul;1(3):230-4
10195148
J Neurophysiol. 1989 Apr;61(4):747-58
2542471
Science. 1993 Jun 4;260(5113):1518-21
8502997