title: 2-year results of the AUTAX (Austrian Multivessel TAXUS-Stent) registry beyond the SYNTAX (synergy between percutaneous coronary intervention with TAXUS and cardiac surgery) study.
abstract: OBJECTIVE
  The multicenter AUTAX (Austrian Multivessel TAXUS-Stent) registry investigated the 2-year clinical/angiographic outcomes of patients with multivessel coronary artery disease after implantation of TAXUS Express stents (Boston Scientific, Natick, Massachusetts), in a "real-world" setting.
  
  
  BACKGROUND
  The AUTAX registry included patients with 2- or 3-vessel disease, with/without previous percutaneous coronary intervention (PCI) and concomitant surgery.
  
  
  METHODS
  Patients (n = 441, 64 +/- 12 years, 78% men) (n = 1,080 lesions) with possible complete revascularization by PCI were prospectively included. Median clinical follow-up was 753 (quartiles 728 to 775) days after PCI in 95.7%, with control angiography of 78% at 6 months. The primary end point was the composite of major adverse cardiac (nonfatal acute myocardial infarction [AMI], all-cause mortality, target lesion revascularization [TLR]) and cerebrovascular events (MACCE). Potential risk factor effects on 2-year MACCE were evaluated using Cox regression.
  
  
  RESULTS
  Complete revascularization was successful in 90.5%, with left main PCI of 6.8%. Rates of acute, subacute, and late stent thrombosis were 0.7%, 0.5%, and 0.5%. Two-year follow-up identified AMI (1.4%), death (3.6%), stroke (0.2%), and TLR (13.1%), for a composite MACCE of 18.3%. The binary restenosis rate was 10.8%. The median of cumulative SYNTAX score was 23.0 (range 12.0 to 56.5). The SYNTAX score did not predict TLR or MACCE, due to lack of scoring of restenotic or bypass stenoses (29.8%). Age (hazard ratio [HR]: 1.03, p = 0.019) and acute coronary syndrome (HR: 2.1, p = 0.001) were significant predictors of 2-year MACCE. Incomplete revascularization predicted death or AMI (HR: 3.84, p = 0.002).
  
  
  CONCLUSIONS
  With the aim of complete revascularization, TAXUS stent implantations can be safe for patients with multivessel disease. The AUTAX registry including patients with post-PCI lesions provides additional information to the SYNTAX (Synergy Between Percutaneous Coronary Intervention With TAXUS and Cardiac Surgery) study. (Austrian Multivessel TAXUS-Stent Registry; NCT00738686).
authors.affiliation: Department of Cardiology, Medical University of Vienna, Vienna, Austria. mariann.gyongyosi@meduniwien.ac.at
authors.forename: Mariann
authors.initials: M
authors.lastname: Gyöngyösi
authors.forename: Günter
authors.initials: G
authors.lastname: Christ
authors.forename: Irene
authors.initials: I
authors.lastname: Lang
authors.forename: Gerhard
authors.initials: G
authors.lastname: Kreiner
authors.forename: Heinz
authors.initials: H
authors.lastname: Sochor
authors.forename: Peter
authors.initials: P
authors.lastname: Probst
authors.forename: Thomas
authors.initials: T
authors.lastname: Neunteufl
authors.forename: Rosa
authors.initials: R
authors.lastname: Badr-Eslam
authors.forename: Susanne
authors.initials: S
authors.lastname: Winkler
authors.forename: Noemi
authors.initials: N
authors.lastname: Nyolczas
authors.forename: Aniko
authors.initials: A
authors.lastname: Posa
authors.forename: Franz
authors.initials: F
authors.lastname: Leisch
authors.forename: Ronald
authors.initials: R
authors.lastname: Karnik
authors.forename: Peter
authors.initials: P
authors.lastname: Siostrzonek
authors.forename: Stefan
authors.initials: S
authors.lastname: Harb
authors.forename: Matthias
authors.initials: M
authors.lastname: Heigert
authors.forename: Gerald
authors.initials: G
authors.lastname: Zenker
authors.forename: Werner
authors.initials: W
authors.lastname: Benzer
authors.forename: Gerhard
authors.initials: G
authors.lastname: Bonner
authors.forename: Alexandra
authors.initials: A
authors.lastname: Kaider
authors.forename: Dietmar
authors.initials: D
authors.lastname: Glogar
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects / Q000295:instrumentation* / Q000401:mortality; D001317:Austria; D017023:Coronary Angiography; D001026:Coronary Artery Bypass / Q000009:adverse effects / Q000401:mortality; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000401:mortality / Q000601:surgery / Q000628:therapy*; D023903:Coronary Restenosis / Q000209:etiology; D054855:Drug-Eluting Stents; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000209:etiology; D016017:Odds Ratio; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D016016:Proportional Hazards Models; D011446:Prospective Studies; D011474:Prosthesis Design; D012042:Registries; D018570:Risk Assessment; D012307:Risk Factors; D012720:Severity of Illness Index; D020521:Stroke / Q000209:etiology; D013927:Thrombosis / Q000209:etiology; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D010975:Platelet Aggregation Inhibitors