Dysoxylum binectariferum Hook.f (Meliaceae), a rich source of rohitukine.
Rohitukine, a chromane alkaloid, is a precursor of flavopiridol, a promising anti-cancer compound. Currently in Phase III clinical trials, flavopiridol is a potent inhibitor of several cyclin-dependent kinases (CDKs). Rohitukine was first reported from Amoora rohituka (0.083% dry weight) followed by that in Dysoxylum binectariferum (0.9% dry weight), both belonging to the family Meliaceae. Here, we report incredibly high yields of rohitukine (7% dry weight) in trees of D. binectariferum from the Western Ghats, India. Crude extracts of the tree were found to be highly effective against ovarian and breast cancer lines tested.
Mohanakumara
Patel
P
Department of Crop Physiology, University of Agricultural Sciences, GKVK Campus, Bangalore 560065, India.
Sreejayan
Nambiar
N
Priti
Vaidayanathan
V
Ramesha
Bheemanahally Thimmappa
BT
Ravikanth
Gudasalamani
G
Ganeshaiah
Kotiganahalli Narayanagowda
KN
Vasudeva
Ramesh
R
Mohan
John
J
Santhoshkumar
Thankayyan Retnabai
TR
Mishra
Prabhu Dutt
PD
Ram
Viswakarma
V
Shaanker
Ramanan Uma
RU
D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy; D045744:Cell Line, Tumor; D005260:Female; D005419:Flavonoids / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D007194:India; D036701:Limonins / Q000302:isolation & purification* / Q000627:therapeutic use; D029582:Meliaceae / Q000737:chemistry*; D009369:Neoplasms / Q000188:drug therapy*; D010051:Ovarian Neoplasms / Q000188:drug therapy; D008517:Phytotherapy; D010880:Piperidines / Q000494:pharmacology* / Q000627:therapeutic use; D024301:Plant Bark; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification* / Q000627:therapeutic use; D018547:Plant Stems; D047428:Protein Kinase Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D014197:Trees / Q000737:chemistry
D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids; D036701:Limonins; D010880:Piperidines; D010936:Plant Extracts; D047428:Protein Kinase Inhibitors; C077990:alvocidib; C105839:rohitukin