title: PSA doubling time as a predictive factor on repeat biopsy for detection of prostate cancer.
abstract: OBJECTIVE
  Detection of prostate cancer needs a biopsy of the prostate. Suspecting cancer from an increase in prostate-specific antigen (PSA) has a high negative rate at an initial prostate biopsy. Cases with negative initial biopsy may be the candidates of subsequent biopsy. For lowering unnecessary repeat biopsy, the use of predictive factors before a repeat biopsy is applied for indication.
  
  
  METHODS
  Seventy-seven cases with negative initial prostate biopsy received a repeat biopsy and factors for the detection of cancer were examined.
  
  
  RESULTS
  PSA doubling time distinguished a part of cancer cases. Its sensitivity of 30, 50 and 70 months was 36.6%, 30.4% and 10%, respectively. Cancer case did not show PSA doubling time of >100 months in general. Values of PSA transition zone density, %Free/total PSA and PSA velocity were similar between cancer and no cancer cases.
  
  
  CONCLUSIONS
  PSA doubling time was one of the predictive factors for the detection of prostate cancer and was valuable for avoiding unnecessary repeat biopsy in some cases.
authors.affiliation: Department of Urology, Graduate School of Medicine, Chiba University, Inohana, Chuo-ku, Chiba-shi 260-8670, Japan. shimajun@opal.famille.ne.jp.
authors.forename: Masashi
authors.initials: M
authors.lastname: Shimbo
authors.forename: Susumu
authors.initials: S
authors.lastname: Tomioka
authors.forename: Makoto
authors.initials: M
authors.lastname: Sasaki
authors.forename: Takayuki
authors.initials: T
authors.lastname: Shima
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Suzuki
authors.forename: Shino
authors.initials: S
authors.lastname: Murakami
authors.forename: Hiroomi
authors.initials: H
authors.lastname: Nakatsu
authors.forename: Jun
authors.initials: J
authors.lastname: Shimazaki
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D001706:Biopsy; D055088:Early Detection of Cancer; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000276:immunology*; D012680:Sensitivity and Specificity; D013997:Time Factors; D019564:Unnecessary Procedures / Q000639:trends
chemical_list: D014408:Biomarkers, Tumor; D017430:Prostate-Specific Antigen