title: In vitro activity of colistin (polymyxin E) against 3,480 isolates of gram-negative bacilli obtained from patients in Canadian hospitals in the CANWARD study, 2007-2008.
abstract: The in vitro activity of colistin was evaluated versus 3,480 isolates of gram-negative bacilli using CLSI broth microdilution methods. The MIC(90) of colistin was < or = 2 microg/ml against a variety of clinically important gram-negative bacilli, including Escherichia coli, Klebsiella spp., Enterobacter spp., Acinetobacter baumannii, and Pseudomonas aeruginosa. All multidrug-resistant (n = 76) P. aeruginosa isolates were susceptible to colistin (MIC, < or = 2 microg/ml). These data support a role for colistin in the treatment of infections caused by multidrug-resistant P. aeruginosa.
authors.affiliation: Health Sciences Centre, Department of Medicine, Winnipeg, Manitoba, Canada R3A 1R9. awalkty@mts.net
authors.forename: A
authors.initials: A
authors.lastname: Walkty
authors.forename: M
authors.initials: M
authors.lastname: DeCorby
authors.forename: K
authors.initials: K
authors.lastname: Nichol
authors.forename: J A
authors.initials: JA
authors.lastname: Karlowsky
authors.forename: D J
authors.initials: DJ
authors.lastname: Hoban
authors.forename: G G
authors.initials: GG
authors.lastname: Zhanel
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003091:Colistin / Q000494:pharmacology*; D024901:Drug Resistance, Multiple, Bacterial; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D003091:Colistin
references.citation: Clin Microbiol Infect. 2006 Apr;12(4):315-21
references.pmid: 16524407
references.citation: Clin Infect Dis. 2003 May 1;36(9):1111-8
references.pmid: 12715304
references.citation: Lancet Infect Dis. 2006 Sep;6(9):589-601
references.pmid: 16931410
references.citation: Crit Care. 2003 Oct;7(5):R78-83
references.pmid: 12974973
references.citation: Int J Antimicrob Agents. 2006 Oct;28(4):366-9
references.pmid: 16971093
references.citation: Clin Infect Dis. 2005 May 1;40(9):1333-41
references.pmid: 15825037
references.citation: Int J Infect Dis. 2007 Sep;11(5):402-6
references.pmid: 17291803
references.citation: Intensive Care Med. 2005 Aug;31(8):1058-65
references.pmid: 15983759
references.citation: J Antimicrob Chemother. 1997 Feb;39(2):255-60
references.pmid: 9069549
references.citation: Singapore Med J. 2006 Jul;47(7):621-4
references.pmid: 16810437