title: Stranger in a strange land: roles of glycogen turnover in adipose tissue metabolism.
abstract: Triglyceride storage in adipose tissue comprises the principal energy reserve in mammals. Additionally glucose can be stored as glycogen in the fed state, primarily in liver and skeletal muscle, for mobilization during times of energy deficit. Adipose tissue also contains glycogen stores albeit at very low levels. The physiological role of glycogen metabolism in adipocytes remains unclear. However, both classical literature and more recent work demonstrate that the dynamic regulation of adipose glycogen may serve as an energy sensing modality in the coordination of glucose and lipid metabolism in adipose tissue, especially during the fasted to fed transition.
authors.affiliation: Department of Medicine, Section of Endocrinology, Diabetes and Metabolism, The University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA.
authors.forename: Kathleen R
authors.initials: KR
authors.lastname: Markan
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Jurczak
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Brady
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D006003:Glycogen / Q000378:metabolism*; D006801:Humans
chemical_list: D006003:Glycogen
references.citation: Proc Natl Acad Sci U S A. 2007 Oct 2;104(40):15753-8
references.pmid: 17898166
references.citation: J Clin Invest. 2000 Feb;105(4):479-88
references.pmid: 10683377
references.citation: J Physiol. 1942 Mar 31;100(4):385-409
references.pmid: 16991534
references.citation: Arch Biochem Biophys. 1960 Dec;91:194-200
references.pmid: 13760945
references.citation: Cell. 1994 Nov 4;79(3):427-36
references.pmid: 7954810
references.citation: Lancet. 1963 Apr 13;1(7285):785-9
references.pmid: 13990765
references.citation: Diabetes Metab. 2004 Sep;30(4):294-309
references.pmid: 15525872
references.citation: Biophys J. 1999 Sep;77(3):1327-32
references.pmid: 10465745
references.citation: J Biol Chem. 2003 Aug 15;278(33):30835-42
references.pmid: 12805359
references.citation: J Biol Chem. 2000 Dec 22;275(51):39991-5
references.pmid: 10998419
references.citation: Curr Biol. 2003 May 13;13(10):867-71
references.pmid: 12747837
references.citation: J Lipid Res. 2006 Sep;47(9):1984-93
references.pmid: 16738357
references.citation: J Clin Invest. 2003 May;111(9):1423-32
references.pmid: 12727934
references.citation: Am J Physiol Gastrointest Liver Physiol. 2007 Jul;293(1):G1-4
references.pmid: 17218471
references.citation: J Cell Sci. 2002 Jan 15;115(Pt 2):241-56
references.pmid: 11839776
references.citation: J Mol Med (Berl). 2002 Dec;80(12):753-69
references.pmid: 12483461
references.citation: J Biol Chem. 1954 May;208(1):431-8
references.pmid: 13174552
references.citation: Circ Res. 2007 Feb 16;100(3):328-41
references.pmid: 17307971
references.citation: Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):12985-90
references.pmid: 18753616
references.citation: Bioessays. 2002 Apr;24(4):371-81
references.pmid: 11948623
references.citation: Am J Physiol Endocrinol Metab. 2001 Oct;281(4):E789-93
references.pmid: 11551856
references.citation: FEBS J. 2005 Mar;272(6):1478-89
references.pmid: 15752363
references.citation: Experientia. 1968 Jun 15;24(6):628-30
references.pmid: 5697761
references.citation: J Biol Chem. 1962 Nov;237:3354-8
references.pmid: 13996476
references.citation: Science. 1997 Mar 7;275(5305):1475-8
references.pmid: 9045612
references.citation: J Biol Chem. 2004 Nov 5;279(45):46474-82
references.pmid: 15322104
references.citation: Prog Nucleic Acid Res Mol Biol. 1997;57:289-316
references.pmid: 9175437
references.citation: J Biol Chem. 1964 Mar;239:675-85
references.pmid: 14154437
references.citation: J Biol Chem. 2000 Aug 25;275(34):26396-403
references.pmid: 10862764
references.citation: J Biol Chem. 2000 Nov 10;275(45):35034-9
references.pmid: 10938087
references.citation: IUBMB Life. 2008 Apr;60(4):204-9
references.pmid: 18344204
references.citation: Am J Physiol Endocrinol Metab. 2007 Mar;292(3):E952-63
references.pmid: 17132821
references.citation: Proc Natl Acad Sci U S A. 1995 Oct 10;92(21):9866-70
references.pmid: 7568234
references.citation: J Biol Chem. 1967 Jun 10;242(11):2746-50
references.pmid: 6027245
references.citation: Trends Endocrinol Metab. 2008 Dec;19(10):356-61
references.pmid: 18929494
references.citation: Biochem J. 1942 Feb;36(1-2):232-41
references.pmid: 16747483
references.citation: Mol Cell Biol. 2006 Jan;26(1):334-42
references.pmid: 16354703
references.citation: J Biol Chem. 1993 Aug 25;268(24):17665-8
references.pmid: 7688729
references.citation: Biochim Biophys Acta. 1955 Dec;18(4):504-10
references.pmid: 13304032
references.citation: J Biol Chem. 2002 Jan 11;277(2):1514-23
references.pmid: 11600496