[Investigation to the levels of 3-nitrotyrosine and their correlation factors in type 2 diabetic patients].
OBJECTIVE
To investigate levels of 3-nitrotyrosine in blood serum, and their correlation factors in type 2 diabetic patients.


METHODS
A randomized case-control trial was carried out, in which 109 type 2 diabetic patients (case group) and 57 non-diabetic patients (control group) were enrolled. Anthropometric measurements, blood biochemical variables and 3-nitrotyrosine (3-NT) were measured.


RESULTS
There were no significant differences between two groups in age, body weight. However, blood glucose, glucosylated serum protein (GSP), total cholesterol, apolipoprotein C2 in case group were more higher than those in control group (P < 0.05). The levels of 3-NT in case group were more higher than those in control group, and 3-NT levels were higher in both male and female diabetic patients than those in non-diabetic male and female patients, respectively (P < 0.05). In case group, patients with BMI > or =28 had more higher 3-NT level than those with BMI < 24, and patients with blood glucose more than 6.1 mmol/L had more higher 3-NT level than those with glucose < or = 6.1 mmol/L (P < 0.05). The results of regression analysis in the case group showed that glucosylated hemoglobin (HbA1c), GSP, low density lipoprotein cholesterol (LDL-c) were the most correlated to 3-NT in blood.


CONCLUSIONS
Levels of 3-NT in case group were higher than those of control group. 3-NT level was closely correlated to HbAlc, GSP, and LDL-c in case group.
Wang
Boshi
B
Department of Nutrition, Chinese PLA General Hospital, Beijing 100853, China. wangboshi_2007@yahoo.com.cn
Liu
Yinghua
Y
Xu
Qing
Q
Wang
Jin
J
D000368:Aged; D016022:Case-Control Studies; D008078:Cholesterol, LDL / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis*; D017127:Glycation End Products, Advanced; D006801:Humans; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D012709:Serum Albumin / Q000032:analysis*; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000097:blood; D000093423:Glycated Serum Albumin
D008078:Cholesterol, LDL; D006442:Glycated Hemoglobin; D017127:Glycation End Products, Advanced; D012709:Serum Albumin; D014443:Tyrosine; D000093423:Glycated Serum Albumin; C002744:3-nitrotyrosine