title: Economic impact of a rotavirus vaccination program in Mexico.
abstract: OBJECTIVE
  To evaluate the cost and benefits of a national rotavirus childhood vaccination program in Mexico.
  
  
  METHODS
  A decision-analysis model was designed to take the Mexican health care system's perspective on a comparison of two alternatives: to vaccinate against rotavirus or not. Using published, national data, estimations were calculated for the rotavirus illnesses, deaths, and disability-adjusted life years (DALYs) that would be averted and the incremental cost-effectiveness ratios (US$/DALY) of a hypothetical annual birth cohort of 2 285 000 children, with certain assumptions made for cost, coverage, and efficacy rates.
  
  
  RESULTS
  With 93% coverage and a vaccine price of US$ 16 per course (2 doses), a rotavirus vaccination program in Mexico would prevent an estimated 651 deaths (or 0.28 deaths per 1 000 children); 13 833 hospitalizations (6.05 hospitalizations per 1 000 children); and 414 927 outpatient visits (182 outpatient visits per 1 000 children) for rotavirus-related acute gastroenteritis (AGE). Vaccination is likely to reduce the economic burden of rotavirus AGE in Mexico by averting US$ 14 million (71% of the overall health care burden). At a vaccine price of US$ 16 per course, the cost-effectiveness ratio would be US$ 1 139 per DALY averted. A reduction in the price of the rotavirus vaccination program (US$ 8 per course) would yield a lower incremental cost-effectiveness ratio of US$ 303 per DALY averted.
  
  
  CONCLUSIONS
  A national rotavirus vaccination program in Mexico is projected to reduce childhood incidence and mortality and to be highly cost-effective based on the World Health Organization's thresholds for cost-effective interventions.
authors.affiliation: Department of Global Health, Emory University, Atlanta, Georgia, United States of America. dagnaconstenla@yahoo.com
authors.forename: Dagna
authors.initials: D
authors.lastname: Constenla
authors.forename: F Raúl
authors.initials: FR
authors.lastname: Velázquez
authors.forename: Richard D
authors.initials: RD
authors.lastname: Rheingans
authors.forename: Lynn
authors.initials: L
authors.lastname: Antil
authors.forename: Yolanda
authors.initials: Y
authors.lastname: Cervantes
mesh_terms: D002675:Child, Preschool; D003362:Cost-Benefit Analysis; D005260:Female; D006801:Humans; D008297:Male; D008800:Mexico; D018803:Models, Economic; D012400:Rotavirus Infections / Q000191:economics* / Q000453:epidemiology / Q000517:prevention & control*; D022243:Rotavirus Vaccines / Q000191:economics*
chemical_list: D022243:Rotavirus Vaccines