Hepatitis B in HIV: available treatment options and approach to therapy.
In the past 5 years, three new drugs were approved for hepatitis B, bringing the total number of therapies to five nucleos(-t)ide analogues and two interferons. Some of these drugs are also active against HIV. As the complexity of hepatitis B treatment increases, it becomes important for practitioners to be familiar with the potency, resistance patterns, and response rates for each hepatitis B agent. In this article, the efficacy in HIV and the best regimens for coinfected patients are discussed for those needing treatment for both infections. A particular emphasis is placed on cross-resistance among hepatitis B drugs.
Osborn
Melissa
M
Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, 550 Peachtree Street NE, Seventh Floor, Medical Office Tower at Emory University Hospital Midtown, Atlanta, GA 30308, USA. mkosbor@emory.edu
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