title: Relapsing polychondritis: new therapeutic strategies with biological agents.
abstract: Relapsing polychondritis (RP) is a rare disease of unknown etiology characterized by recurrent episodes of inflammation resulting in the destruction of cartilaginous tissues. We describe a young girl with RP unresponsive to conventional therapy.
authors.affiliation: Department of Pediatrics, Pediatric Rheumatology, Ospedale Pediatrico Bambino Gesù IRCCS, Piazza S. Onofrio, 4, 00135, Rome, Italy. psabrina.buonuomo@opbg.net
authors.forename: Paola Sabrina
authors.initials: PS
authors.lastname: Buonuomo
authors.forename: Claudia
authors.initials: C
authors.lastname: Bracaglia
authors.forename: Andrea
authors.initials: A
authors.lastname: Campana
authors.forename: Maya
authors.initials: M
authors.lastname: El Hachem
authors.forename: Andrea
authors.initials: A
authors.lastname: Diociaiuti
authors.forename: Antonella
authors.initials: A
authors.lastname: Insalaco
authors.forename: Fabrizio
authors.initials: F
authors.lastname: De Benedetti
authors.forename: Beatrice Chiarini
authors.initials: BC
authors.lastname: Testa
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Cortis
authors.forename: Giovanni Carlo
authors.initials: GC
authors.lastname: De Vincentiis
authors.forename: Alberto G
authors.initials: AG
authors.lastname: Ugazio
mesh_terms: D000293:Adolescent; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D000069285:Infliximab; D053590:Interleukin 1 Receptor Antagonist Protein / Q000627:therapeutic use*; D007442:Intubation, Intratracheal; D011081:Polychondritis, Relapsing / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D020551:Pulse Therapy, Drug; D012121:Respiration, Artificial; D012128:Respiratory Distress Syndrome / Q000209:etiology / Q000628:therapy; D013256:Steroids / Q000008:administration & dosage; D014139:Tracheostomy; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D000911:Antibodies, Monoclonal; D007166:Immunosuppressive Agents; D053590:Interleukin 1 Receptor Antagonist Protein; D013256:Steroids; D000069285:Infliximab
references.citation: J Rheumatol. 2003 Jun;30(6):1394-5
references.pmid: 12784426
references.citation: Medicine (Baltimore). 1976 May;55(3):193-215
references.pmid: 775252
references.citation: Joint Bone Spine. 2008 Oct;75(5):622-4
references.pmid: 18674946
references.citation: Clin Exp Rheumatol. 2004 Sep-Oct;22(5):629-31
references.pmid: 15485019
references.citation: Mod Rheumatol. 2007;17(2):144-7
references.pmid: 17437170
references.citation: Rheumatology (Oxford). 2006 Apr;45(4):491-2
references.pmid: 16510529
references.citation: Semin Arthritis Rheum. 2002 Jun;31(6):384-95
references.pmid: 12077711
references.citation: Br J Dermatol. 1992 Sep;127(3):300
references.pmid: 1390179
references.citation: Rheumatology (Oxford). 2003 Sep;42(9):1117-8
references.pmid: 12923271
references.citation: Ann Intern Med. 1986 Jan;104(1):74-8
references.pmid: 3484422