Mobilization of progenitor cells into the blood by immobilized granulocytic colony-stimulating factor.
The effects of granulocytic CSF immobilized on polyethylenoxide by nanotechnology on the bone marrow and circulating pools of mesenchymal and hemopoietic precursors were studied. Immobilized granulocytic CSF caused the release of progenitor cells of different classes into the blood. The effect of injected immobilized granulocytic CSF was superior to that of nonconjugated granulocytic CSF. Specific activity of oral immobilized granulocytic CSF after oral administration was demonstrated.
Dygai
A M
AM
Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk. mmu@pharm.tsu.ru
Vereshchagin
E I
EI
Zyuz'kov
G N
GN
Zhdanov
V V
VV
Madonov
P G
PG
Simanina
E V
EV
Stavrova
L A
LA
Udut
E V
EV
Khrichkova
T Yu
TY
Miroshnichenko
L A
LA
Minakova
M Yu
MY
Ermakova
N N
NN
Firsova
T V
TV
D000818:Animals; D001790:Blood Physiological Phenomena / Q000187:drug effects*; D001853:Bone Marrow / Q000187:drug effects; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000008:administration & dosage / Q000494:pharmacology*; D006133:Growth Substances / Q000008:administration & dosage / Q000494:pharmacology*; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000502:physiology; D059630:Mesenchymal Stem Cells / Q000187:drug effects / Q000502:physiology; D051379:Mice; D008808:Mice, Inbred CBA; D013234:Stem Cells / Q000187:drug effects* / Q000502:physiology*; D013997:Time Factors
D006133:Growth Substances; D016178:Granulocyte-Macrophage Colony-Stimulating Factor