title: Uncombable hair syndrome.
abstract: Uncombable hair syndrome is a relatively rare anomaly of the hair shaft, with less than 100 cases reported to date, that results in a disorganized, unruly hair pattern that is impossible to comb flat. The characteristic longitudinal grooves along the hair shaft, along with the triangular or kidney-shaped cross section allows this condition to be diagnosed microscopically. The majority of cases are inherited in an autosomal-dominant manner with either complete or incomplete penetrance. There is no definitive treatment, and most cases improve with the onset of puberty.
authors.affiliation: Department of Dermatology and Skin Science, University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: Pamela
authors.initials: P
authors.lastname: Calderon
authors.forename: Nina
authors.initials: N
authors.lastname: Otberg
authors.forename: Jerry
authors.initials: J
authors.lastname: Shapiro
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004476:Ectodermal Dysplasia / Q000235:genetics* / Q000473:pathology*; D005260:Female; D005799:Genes, Dominant; D006197:Hair / Q000473:pathology* / Q000648:ultrastructure; D006201:Hair Diseases / Q000235:genetics / Q000473:pathology*; D006203:Hair Preparations; D006801:Humans; D008854:Microscopy, Electron
chemical_list: D006203:Hair Preparations