Increased tissue factor expression and poor nephroblastoma prognosis.
OBJECTIVE
There is potential interaction between malignant cell growth and the coagulation pathway. Recent studies suggest that tissue factor, a primary initiator of the extrinsic coagulation pathway, is expressed in various solid tumors in association with increased angiogenesis. To our knowledge we report for the first time the detection of tissue factor expression by immunohistochemistry in Wilms tumors and its correlation with clinical outcomes.


METHODS
Tissue factor expression detected by immunohistochemistry was assessed in 41 formalin fixed, paraffin embedded Wilms tumor cases treated at university hospitals. We correlated findings with tumor recurrence and cancer specific survival.


RESULTS
Positive immunohistochemistry detection of tissue factor was observed in 88.3% of the tumors analyzed. Tissue factor on immunohistochemistry was associated with tumor recurrence and survival (p = 0.01 and 0.02, respectively). Increased immunohistochemical detection of tissue factor was the most important risk factor for recurrence and mortality in our population on bivariate and multivariate analysis.


CONCLUSIONS
Tissue factor is a promising research subject as a prognostic factor for Wilms tumor. More studies are needed to clarify the mechanisms by which tissue factor affects cancer progression and outcome, and its potential role as a therapeutic target.
Maciel
Elinês O
EO
Department of Pediatric Surgery, Pontifícia Universidade Católica, Porto Alegre, Brazil.
Carvalhal
Gustavo F
GF
da Silva
Vinícius D
VD
Batista
Eraldo L
EL
Garicochea
Bernardo
B
D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D007680:Kidney Neoplasms / Q000737:chemistry / Q000378:metabolism* / Q000401:mortality; D008297:Male; D011379:Prognosis; D015996:Survival Rate; D013925:Thromboplastin / Q000032:analysis / Q000096:biosynthesis*; D009396:Wilms Tumor / Q000737:chemistry / Q000378:metabolism* / Q000401:mortality
D013925:Thromboplastin