title: Biomarkers of lung-related diseases: current knowledge by proteomic approaches.
abstract: The lung epithelial surface is one of the vital barriers or sensors in the body responding to the external atmosphere and thereby always subjecting to direct toxicological exposure, stress, stimulus, or infection. Due to its relatively higher sensitivity in response to toxicants, the use of lung epithelial cell culture and lung tissue from animal models or patients has facilitated our learning to lung physiopathology and toxicopharmacology. The recent advancement of proteomics has made it possible to investigate the cellular response at a global level. In this review, the potential applications of proteomic approach in studying lung-related diseases and biomarker discovery will be discussed.
authors.affiliation: Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, People's Republic of China.
authors.forename: Andy T Y
authors.initials: AT
authors.lastname: Lau
authors.forename: Jen-Fu
authors.initials: JF
authors.lastname: Chiu
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood / Q000378:metabolism* / Q000652:urine; D003141:Communicable Diseases / Q000378:metabolism; D003550:Cystic Fibrosis / Q000378:metabolism; D006801:Humans; D006967:Hypersensitivity / Q000378:metabolism; D008171:Lung Diseases / Q000097:blood / Q000378:metabolism* / Q000652:urine; D008175:Lung Neoplasms / Q000378:metabolism; D040901:Proteomics / Q000379:methods*
chemical_list: D015415:Biomarkers
references.citation: Science. 1995 Aug 11;269(5225):847-50
references.pmid: 7543698
references.citation: Clin Chem. 2005 Jan;51(1):47-55
references.pmid: 15364884
references.citation: Int J Cancer. 2005 Oct 10;116(6):963-71
references.pmid: 15880414
references.citation: Proteomics. 2004 Feb;4(2):492-504
references.pmid: 14760722
references.citation: N Engl J Med. 2000 Dec 14;343(24):1742-9
references.pmid: 11114312
references.citation: Chest. 2007 Aug;132(2):489-96
references.pmid: 17550934
references.citation: Proteomics. 2006 May;6(9):2886-94
references.pmid: 16649161
references.citation: J Clin Microbiol. 2000 Jun;38(6):2354-61
references.pmid: 10835002
references.citation: Respir Res. 2001;2(2):80-4
references.pmid: 11686869
references.citation: Annu Rev Genet. 1995;29:777-807
references.pmid: 8825494
references.citation: Mol Cell Proteomics. 2005 Nov;4(11):1762-75
references.pmid: 16099848
references.citation: N Engl J Med. 2003 May 15;348(20):1953-66
references.pmid: 12690092
references.citation: Clin Chem. 2006 Mar;52(3):421-9
references.pmid: 16423906
references.citation: Eur Respir J. 2003 Oct;22(4):672-88
references.pmid: 14582923
references.citation: Lung Cancer. 2006 Oct;54(1):87-94
references.pmid: 16876904
references.citation: Proteomics. 2004 Nov;4(11):3308-17
references.pmid: 15378753
references.citation: Methods Mol Biol. 2008;425:101-12
references.pmid: 18369890
references.citation: Proteomics. 2004 Nov;4(11):3477-84
references.pmid: 15378763
references.citation: Toxicol Appl Pharmacol. 1997 Jul;145(1):10-22
references.pmid: 9221819
references.citation: Mol Cell Proteomics. 2005 Jul;4(7):902-13
references.pmid: 15784933
references.citation: Clin Chest Med. 1995 Dec;16(4):583-602
references.pmid: 8565402
references.citation: Respir Care Clin N Am. 2003 Sep;9(3):283-96, vii-viii
references.pmid: 14690067
references.citation: Proteomics. 2005 Mar;5(4):1140-9
references.pmid: 15693063
references.citation: Radiology. 2005 Apr;235(1):259-65
references.pmid: 15695622
references.citation: J Immunol. 2006 May 1;176(9):5587-97
references.pmid: 16622028
references.citation: N Engl J Med. 2000 May 4;342(18):1334-49
references.pmid: 10793167
references.citation: Cancer Res. 2007 Mar 1;67(5):2107-13
references.pmid: 17332340
references.citation: J Proteome Res. 2009 Apr;8(4):1631-8
references.pmid: 19714806
references.citation: Clin Chim Acta. 2008 Feb;388(1-2):173-8
references.pmid: 18036563
references.citation: Infect Immun. 2003 Dec;71(12):6871-83
references.pmid: 14638775
references.citation: J Proteome Res. 2004 Jul-Aug;3(4):728-35
references.pmid: 15359725
references.citation: J Pathol. 2009 Jan;217(1):54-64
references.pmid: 18798225
references.citation: Glycobiology. 2007 Jul;17(7):698-712
references.pmid: 17392389
references.citation: Proteomics. 2005 May;5(8):2210-26
references.pmid: 15852339
references.citation: Cancer Sci. 2007 Aug;98(8):1265-74
references.pmid: 17537172
references.citation: Eur Respir J. 1998 Mar;11(3):529-33
references.pmid: 9596097
references.citation: J Proteome Res. 2007 Mar;6(3):1083-92
references.pmid: 17284061
references.citation: N Engl J Med. 2003 May 15;348(20):1967-76
references.pmid: 12690091
references.citation: Mol Cell Proteomics. 2007 Jan;6(1):56-63
references.pmid: 17028300
references.citation: Proteomics. 2007 Dec;7(23):4388-97
references.pmid: 17963277
references.citation: Science. 1962 Aug 24;137(3530):577-85
references.pmid: 14005590
references.citation: J Biol Chem. 2003 Dec 12;278(50):50781-90
references.pmid: 14522998
references.citation: Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17039-44
references.pmid: 15572443
references.citation: Am J Respir Med. 2003;2(4):299-309
references.pmid: 14719996
references.citation: J Clin Oncol. 2007 Dec 10;25(35):5578-83
references.pmid: 18065730
references.citation: Annu Rev Microbiol. 2003;57:517-49
references.pmid: 14527290
references.citation: Clin Cancer Res. 2002 Jul;8(7):2298-305
references.pmid: 12114434
references.citation: Proteomics. 2004 Nov;4(11):3299-307
references.pmid: 15378731
references.citation: J Proteome Res. 2008 Dec;7(12):5125-32
references.pmid: 19367700
references.citation: Respirology. 2006 May;11(3):269-75
references.pmid: 16635084
references.citation: Proteomics. 2006 Jun;6(11):3381-8
references.pmid: 16637013
references.citation: Respir Res. 2005 Apr 13;6:34
references.pmid: 15829015
references.citation: Am J Pathol. 2006 Jul;169(1):86-95
references.pmid: 16816363
references.citation: Mol Genet Metab. 2006 Apr;87(4):303-10
references.pmid: 16406648
references.citation: J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Feb 5;815(1-2):169-78
references.pmid: 15652807
references.citation: Proteomics. 2004 Nov;4(11):3328-34
references.pmid: 15378764
references.citation: Am J Respir Crit Care Med. 2005 Dec 1;172(11):1416-26
references.pmid: 16166615
references.citation: Mol Cell Proteomics. 2005 Aug;4(8):1052-60
references.pmid: 15901828
references.citation: Clin Diagn Lab Immunol. 2002 Jul;9(4):883-91
references.pmid: 12093690
references.citation: Am J Respir Crit Care Med. 2008 Oct 1;178(7):701-9
references.pmid: 18658106
references.citation: CA Cancer J Clin. 2005 Jan-Feb;55(1):10-30
references.pmid: 15661684
references.citation: Am J Respir Crit Care Med. 2005 Nov 1;172(9):1090-6
references.pmid: 16100010
references.citation: Am Rev Respir Dis. 1992 Feb;145(2 Pt 1):317-25
references.pmid: 1310575
references.citation: Expert Rev Proteomics. 2007 Oct;4(5):627-37
references.pmid: 17941818
references.citation: J Mol Biol. 2004 Jul 30;341(1):271-9
references.pmid: 15312778
references.citation: Biochem Biophys Res Commun. 2001 Nov 30;289(2):507-12
references.pmid: 11716502
references.citation: J Clin Pathol. 2001 Aug;54(8):577-89
references.pmid: 11477111
references.citation: Proteomics. 2005 Jul;5(11):2972-80
references.pmid: 16075419
references.citation: Am J Respir Crit Care Med. 2008 Feb 1;177(3):269-78
references.pmid: 18006888
references.citation: Proteomics. 2006 Apr;6(8):2485-94
references.pmid: 16548060
references.citation: Environ Health Perspect. 1976 Aug;16:55-60
references.pmid: 797568
references.citation: Thorax. 1996 Dec;51(12):1216-22
references.pmid: 8994518
references.citation: J Anat. 2002 Oct;201(4):313-8
references.pmid: 12430955
references.citation: Neoplasia. 2002 Sep-Oct;4(5):440-8
references.pmid: 12192603
references.citation: Environ Health Perspect. 2005 Apr;113(4):454-60
references.pmid: 15811836
references.citation: Clin Chem. 2007 Oct;53(10):1782-91
references.pmid: 17702859
references.citation: Lancet. 2006 Sep 16;368(9540):1012-21
references.pmid: 16980117
references.citation: Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4011-6
references.pmid: 16537477
references.citation: Proteomics. 2006 Jul;6(13):3949-57
references.pmid: 16767788
references.citation: Cancer. 2007 Mar 15;109(6):1164-73
references.pmid: 17315157
references.citation: Int Rev Cytol. 1988;111:231-69
references.pmid: 3074961
references.citation: Annu Rev Med. 2002;53:477-98
references.pmid: 11818486
references.citation: Mol Cell Proteomics. 2006 Sep;5(9):1628-37
references.pmid: 16829594
references.citation: Am J Respir Cell Mol Biol. 1995 Feb;12(2):220-6
references.pmid: 7865220
references.citation: Proteomics. 2005 Jul;5(11):2799-807
references.pmid: 15996009
references.citation: Am J Respir Cell Mol Biol. 2005 Sep;33(3):290-6
references.pmid: 15961726
references.citation: Am J Respir Crit Care Med. 1995 Mar;151(3 Pt 2):S47-53
references.pmid: 7533605
references.citation: Mol Cell Proteomics. 2005 Oct;4(10):1591-601
references.pmid: 16014420
references.citation: Am J Respir Cell Mol Biol. 2008 May;38(5):541-50
references.pmid: 18079489
references.citation: Proteomics. 2006 Jan;6(2):547-58
references.pmid: 16342241
references.citation: Chest. 2009 Feb;135(2):344-352
references.pmid: 18753468
references.citation: Lancet. 2004 Aug 21-27;364(9435):709-21
references.pmid: 15325838
references.citation: J Proteome Res. 2004 May-Jun;3(3):549-55
references.pmid: 15253436
references.citation: Environ Health Perspect. 2002 Aug;110(8):A440-1
references.pmid: 12153769
references.citation: Proteomics. 2007 Nov;7(21):3906-18
references.pmid: 17922515
references.citation: Lancet. 2003 Apr 19;361(9366):1319-25
references.pmid: 12711465
references.citation: J Toxicol Environ Health A. 2003 Jun 27;66(12):1087-112
references.pmid: 12854532
references.citation: Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 2003 Nov;35(11):965-75
references.pmid: 14614532
references.citation: Environ Health Perspect. 2000 Oct;108(10):941-7
references.pmid: 11049813