Flavonoids and brain health: multiple effects underpinned by common mechanisms.
The neuroprotective actions of dietary flavonoids involve a number of effects within the brain, including a potential to protect neurons against injury induced by neurotoxins, an ability to suppress neuroinflammation, and the potential to promote memory, learning and cognitive function. This multiplicity of effects appears to be underpinned by two processes. Firstly, they interact with important neuronal signalling cascades leading to an inhibition of apoptosis triggered by neurotoxic species and to a promotion of neuronal survival and differentiation. These interactions include selective actions on a number of protein kinase and lipid kinase signalling cascades, most notably the PI3K/Akt and MAP kinase pathways which regulate pro-survival transcription factors and gene expression. Secondly, they induce peripheral and cerebral vascular blood flow in a manner which may lead to the induction of angiogenesis, and new nerve cell growth in the hippocampus. Therefore, the consumption of flavonoid-rich foods, such as berries and cocoa, throughout life holds a potential to limit the neurodegeneration associated with a variety of neurological disorders and to prevent or reverse normal or abnormal deteriorations in cognitive performance.
Spencer
Jeremy P E
JP
Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, University of Reading, Reading, RG2 6AP, UK, j.p.e.spencer@reading.ac.uk.
J Neurochem. 2007 Nov;103(4):1355-67
17961201
Biochem J. 2001 Mar 15;354(Pt 3):493-500
11237853
J Neurochem. 2001 Sep;78(5):1073-82
11553681
Genes Nutr. 2008 Dec;3(3-4):115-26
18937002
Glia. 2003 Jan 15;41(2):152-60
12509805
Science. 2000 Feb 25;287(5457):1433-8
10688783
J Cell Mol Med. 2001 Jan-Mar;5(1):1-17
12067447
Biochem Biophys Res Commun. 2007 Oct 19;362(2):340-6
17716620
J Agric Food Chem. 2008 Feb 13;56(3):636-41
18211020
Am J Med. 2006 Sep;119(9):751-9
16945610
J Hist Behav Sci. 2002 Winter;38(1):3-25
11835218
Br J Nutr. 2008 May;99 E Suppl 1:ES60-77
18503736
J Neurochem. 2007 Jun;101(6):1596-606
17298385
Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12197-202
12213959
FASEB J. 2003 Oct;17(13):1943-4
12897065
Arch Biochem Biophys. 2008 Aug 15;476(2):145-51
18394421
J Biol Chem. 1999 Jan 22;274(4):2234-42
9890986
Free Radic Biol Med. 1996;20(7):933-56
8743980
J Comp Neurol. 2000 Oct 2;425(4):479-94
10975875
Neurosignals. 2005;14(1-2):46-60
15956814
J Neurochem. 1998 Nov;71(5):2112-22
9798937
Am J Clin Nutr. 2006 Feb;83(2):355-61
16469995
Biochem Biophys Res Commun. 2006 Dec 1;350(4):960-8
17045238
Genes Nutr. 2007 Dec;2(3):257-73
18850181
Parkinsonism Relat Disord. 2005 Jun;11 Suppl 1:S9-S15
15885630
J Neurochem. 1995 Feb;64(2):919-24
7830086
Free Radic Biol Med. 2004 Dec 1;37(11):1683-93
15528027
Eur J Pharmacol. 2005 Oct 3;521(1-3):9-20
16171798
Eur Neurol. 2003;50(1):1-9
12824705
Chem Soc Rev. 2009 Apr;38(4):1152-61
19421586
Ann Neurol. 2005 Jun;57(6):789-94
15929050
J Neurosci Res. 2007 Apr;85(5):1010-7
17265471
Neuroimage. 2008 Feb 1;39(3):973-8
17988892
Curr Mol Med. 2003 Jun;3(4):361-72
12776991
Am J Physiol. 1999 Sep;277(3):C403-11
10484327
J Neurochem. 2007 Feb;100(4):992-1002
17156130
Bull Math Biol. 1990;52(1-2):99-115; discussion 73-97
2185863
Proc Nutr Soc. 2008 May;67(2):238-52
18412998
Ann N Y Acad Sci. 2007 Apr;1100:470-85
17460212
J Neurosci. 1998 Oct 1;18(19):8047-55
9742171
J Cardiovasc Pharmacol. 2006;47 Suppl 2:S210-4
16794460
J Nutr. 2006 Apr;136(4):1043-7
16549472
Arch Biochem Biophys. 2009 Apr 1;484(1):100-9
19467635
Eur J Epidemiol. 2000 Apr;16(4):357-63
10959944
Free Radic Biol Med. 2008 Aug 1;45(3):295-305
18457678
Future Lipidol. 2007 Aug;2(4):403-422
18176634
FEBS J. 2005 May;272(10):2347-61
15885086
Free Radic Biol Med. 2004 Aug 1;37(3):304-17
15223064
Kidney Int. 2000 Sep;58(3):1078-87
10972672
Proc Natl Acad Sci U S A. 2008 May 27;105(21):7534-9
18490655
J Biol Chem. 2003 Sep 12;278(37):34783-93
12826665
Annu Rev Neurosci. 1994;17:341-71
8210179
Biochem J. 2001 Sep 15;358(Pt 3):547-57
11535118
J Biol Chem. 2002 Aug 16;277(33):29584-92
12048217
Endeavour. 2003 Mar;27(1):32-6
12642144
J Alzheimers Dis. 2008 Oct;15(2):211-22
18953110
Am J Clin Nutr. 2005 Jan;81(1 Suppl):313S-316S
15640496
J Cardiovasc Pharmacol. 2006;47 Suppl 2:S215-20
16794461
Br J Pharmacol. 2006 May;148(2):147-53
16547523
Ann N Y Acad Sci. 2002 Apr;959:128-32
11976192
Free Radic Biol Med. 2004 Apr 1;36(7):838-49
15019969
Proc Natl Acad Sci U S A. 2006 Jan 24;103(4):1024-9
16418281
Nutrition. 2006 Mar;22(3):295-302
16412610
Oncogene. 2003 Feb 20;22(7):1035-44
12592390
J Neurosci. 1999 Sep 15;19(18):8114-21
10479711
Exp Gerontol. 2004 Jul;39(7):1027-34
15236762
Int Immunopharmacol. 2008 Mar;8(3):484-94
18279803
Biochem Pharmacol. 2002 Jan 1;63(1):21-9
11754870
J Neurosci Res. 2004 Dec 1;78(5):723-31
15478178
J Neurosci. 1998 Mar 1;18(5):1633-41
9464988
Free Radic Biol Med. 2001 Nov 1;31(9):1139-46
11677047
CNS Neurosci Ther. 2008 Winter;14(4):352-65
19040558
J Neurosci Res. 2005 Dec 1;82(5):717-28
16247808
Trends Mol Med. 2003 Mar;9(3):126-32
12657434
Nutr Neurosci. 2003 Jun;6(3):153-62
12793519
Nephron. 2002 May;91(1):142-7
12021531
Neurosci Lett. 2000 Aug 11;289(3):201-4
10961664
Neurosci Lett. 2000 Jun 30;287(3):191-4
10863027
Prog Neuropsychopharmacol Biol Psychiatry. 2003 Aug;27(5):741-9
12921904
J Neurochem. 2002 Apr;81(1):122-9
12067224