Hyperspectral excitation-resolved fluorescence tomography of quantum dots.
The proposed method exploits the spectral properties of tissue hemoglobin for the purpose of 3D image reconstruction of quantum dot reporter probes inside scattering tissue. It advances fluorescence tomography in such way that only a single light source with tunable wavelength selection is required for fluorescence stimulation and image reconstruction. Numerical results suggest that current planar surface imaging technology could easily be retrofitted for performing fluorescence tomography without the use of elaborate source-detector multiplexing.
Klose
Alexander D
AD
Department of Radiology, Columbia University, ET351 Mudd Building, MC 8904, 500 West 120th Street,New York, New York 10027, USA. ak2083@columbia.edu
D000042:Absorption; D000818:Animals; D005453:Fluorescence; D006454:Hemoglobins / Q000378:metabolism; D007091:Image Processing, Computer-Assisted; D045663:Quantum Dots; D014054:Tomography / Q000379:methods*
D006454:Hemoglobins
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