title: Successful Primary Treatment of a Hydatidiform Mole with Methotrexate and EMA/CO.
abstract: Background. The preferred treatment method of most hydatidiform moles is suction aspiration. In rare circumstances uterine abnormalities may preclude surgical treatment. Case. We report a case of complete molar pregnancy successfully treated with methotrexate followed by EMA/CO. A 38-year-old woman with a complete hydatidiform mole and multiple uterine fibroids underwent a failed attempt at suction aspiration. Following treatment with methotrexate, a nonmetastatic persistent trophoblastic tumour developed. Six cycles of EMA/CO led to complete remission. Conclusion. We propose that primary treatment of molar pregnancies with chemotherapy is a useful treatment option in cases where uterine abnormalities interfere with suction aspiration.
authors.affiliation: Department of Gynaecology, Academic Hospital, Brussels Free University - (VUB), UZ Brussel, 1090 Brussels, Belgium.
authors.forename: M
authors.initials: M
authors.lastname: De Vos
authors.forename: M
authors.initials: M
authors.lastname: Leunen
authors.forename: C
authors.initials: C
authors.lastname: Fontaine
authors.forename: Ph
authors.initials: P
authors.lastname: De Sutter
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