Impairment in anthropometric parameters and body composition in females with classical 21-hydroxylase deficiency.
The aim of this study was to evaluate the physical measurements and body composition of female patients with the classic form of congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency. Twenty-eight girls with CAH were classified according to both hormonal control (well or not well controlled) and the clinical form of the disease (simple virilizing or salt-wasting). In the control group, 112 healthy individuals were included, divided into two subgroups (male and female). Both patients and controls were subdivided by age into three groups according to pubertal stage: < or =10 years (prepubertal), 11-15 years (pubertal), and > or =15 years (postpubertal). Anthropometrical evaluations and bioelectrical impedance were used to obtain the physical measurement and body composition data. The patients with the simple virilizing form presented higher values for BMI, waist, arm fat area, and fat mass percentage. The not well controlled group presented shorter leg length. Values obtained for BMI as well as for arm fat area, brachial circumference, waist, hip, bi-iliac diameter and fat mass percentage were significantly higher in the patients than in the controls, whereas leg length, hand size and the percentages of water and lean mass were lower. Alterations in body composition were observed in all age groups, mainly by increase of fat mass with age. After puberty, impairments in limb measurements (leg, hand and foot) were more evident. Patients with CAH presented differences in anthropometric parameters but mainly in body composition. Hence, more comprehensive and careful anthropometric evaluation during monitoring of patients with CAH is recommended.
Gonçalves
Ezequiel Moreira
EM
Department of Pediatrics, Faculty of Medical Sciences, University of Campinas, Brazil.
de Lemos-Marini
Sofia Helena Valente
SH
de Mello
Maricilda Palandi
MP
Baptista
Maria Tereza Matias
MT
D'Souza-Li
Lilia Freire Rodrigues
LF
Baldin
Alexandre Duarte
AD
Carvalho
Wellington Roberto Gomes
WR
Farias
Edson Santos
ES
Guerra-Junior
Gil
G
D000293:Adolescent; D000312:Adrenal Hyperplasia, Congenital / Q000097:blood* / Q000503:physiopathology; D000886:Anthropometry; D001823:Body Composition / Q000235:genetics*; D015992:Body Mass Index; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D017097:Electric Impedance; D005260:Female; D006801:Humans; D008297:Male; D011446:Prospective Studies; D013255:Steroid 21-Hydroxylase / Q000097:blood*; D055815:Young Adult
D013255:Steroid 21-Hydroxylase