title: ArachnoServer: a database of protein toxins from spiders.
abstract: BACKGROUND
  Venomous animals incapacitate their prey using complex venoms that can contain hundreds of unique protein toxins. The realisation that many of these toxins may have pharmaceutical and insecticidal potential due to their remarkable potency and selectivity against target receptors has led to an explosion in the number of new toxins being discovered and characterised. From an evolutionary perspective, spiders are the most successful venomous animals and they maintain by far the largest pool of toxic peptides. However, at present, there are no databases dedicated to spider toxins and hence it is difficult to realise their full potential as drugs, insecticides, and pharmacological probes.
  
  
  METHODS
  We have developed ArachnoServer, a manually curated database that provides detailed information about proteinaceous toxins from spiders. Key features of ArachnoServer include a new molecular target ontology designed especially for venom toxins, the most up-to-date taxonomic information available, and a powerful advanced search interface. Toxin information can be browsed through dynamic trees, and each toxin has a dedicated page summarising all available information about its sequence, structure, and biological activity. ArachnoServer currently manages 567 protein sequences, 334 nucleic acid sequences, and 51 protein structures.
  
  
  CONCLUSIONS
  ArachnoServer provides a single source of high-quality information about proteinaceous spider toxins that will be an invaluable resource for pharmacologists, neuroscientists, toxinologists, medicinal chemists, ion channel scientists, clinicians, and structural biologists. ArachnoServer is available online at http://www.arachnoserver.org.
authors.affiliation: Queensland Facility for Advanced Bioinformatics, The University of Queensland, St Lucia, QLD 4072, Australia. d.wood@imb.uq.edu.au
authors.forename: David L A
authors.initials: DL
authors.lastname: Wood
authors.forename: Tomas
authors.initials: T
authors.lastname: Miljenović
authors.forename: Shuzhi
authors.initials: S
authors.lastname: Cai
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Raven
authors.forename: Quentin
authors.initials: Q
authors.lastname: Kaas
authors.forename: Pierre
authors.initials: P
authors.lastname: Escoubas
authors.forename: Volker
authors.initials: V
authors.lastname: Herzig
authors.forename: David
authors.initials: D
authors.lastname: Wilson
authors.forename: Glenn F
authors.initials: GF
authors.lastname: King
mesh_terms: D000818:Animals; D030562:Databases, Protein; D020407:Internet; D013111:Spider Venoms / Q000737:chemistry*; D013112:Spiders / Q000737:chemistry*; D014584:User-Computer Interface
chemical_list: D013111:Spider Venoms
references.citation: Nature. 2001 Jan 4;409(6816):35-6
references.pmid: 11343101
references.citation: Nucleic Acids Res. 2008 Jan;36(Database issue):D293-7
references.pmid: 17933766
references.citation: Transgenic Res. 2006 Jun;15(3):349-57
references.pmid: 16779650
references.citation: Toxicon. 2004 Apr;43(5):509-25
references.pmid: 15066410
references.citation: Nucleic Acids Res. 2000 Jan 1;28(1):235-42
references.pmid: 10592235
references.citation: Nat Neurosci. 2007 Aug;10(8):943-5
references.pmid: 17632507
references.citation: Bioinformatics. 2008 Feb 1;24(3):445-6
references.pmid: 18065428
references.citation: Toxicon. 2004 Apr;43(5):601-18
references.pmid: 15066416
references.citation: Toxicon. 2006 Mar;47(3):356-63
references.pmid: 16445955
references.citation: Nucleic Acids Res. 2008 Jan;36(Database issue):D25-30
references.pmid: 18073190
references.citation: Toxicon. 2004 Apr;43(5):527-42
references.pmid: 15066411
references.citation: Peptides. 2005 Jan;26(1):131-9
references.pmid: 15626513
references.citation: Toxicon. 2008 Aug 1;52(2):264-76
references.pmid: 18619481
references.citation: Nucleic Acids Res. 2003 Jan 1;31(1):365-70
references.pmid: 12520024
references.citation: Toxicon. 2008 Jun 1;51(7):1197-206
references.pmid: 18397797
references.citation: Toxicon. 2006 May;47(6):650-63
references.pmid: 16574177
references.citation: Nucleic Acids Res. 1997 Sep 1;25(17):3389-402
references.pmid: 9254694
references.citation: Toxicon. 2005 Mar 1;45(3):293-301
references.pmid: 15683867
references.citation: J Insect Physiol. 2004 Jan;50(1):61-71
references.pmid: 15037094
references.citation: Br J Pharmacol. 2008 Mar;153 Suppl 2:S1-209
references.pmid: 18347570