title: Audiogenic epilepsy in mice with different genotypes after neonatal treatments enhancing neurogenesis in dentate gyrus.
abstract: Pups of Wistar and KM rats (with predisposition to audiogenic epilepsy) were daily injected with neuropeptide semax (50 mg/kg) or NO-synthase inhibitor L-NAME (50 mg/kg) on days 7-11 of life. Alterations of audiogenic seizures pattern were revealed in rats of both strains at the age of 1 month, while changes in seizure severity were genotype-dependent. Both agents enhance neurogenesis in the dentate gyrus of the hippocampus and the delayed effect in the form of altered seizure pattern seems to be determined by this factor. Genotype-dependent alterations of seizure severity after administration of semax and L-NAME were differently directed. These effects are suggested to be underlined by physiological and biochemical mechanisms not related to the intensity of postnatal neurogenesis.
authors.affiliation: Biological Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia.
authors.forename: T V
authors.initials: TV
authors.lastname: Timoshenko
authors.forename: O V
authors.initials: OV
authors.lastname: Perepelkina
authors.forename: N V
authors.initials: NV
authors.lastname: Markina
authors.forename: A V
authors.initials: AV
authors.lastname: Revischin
authors.forename: G V
authors.initials: GV
authors.lastname: Pavlova
authors.forename: I I
authors.initials: II
authors.lastname: Poletaeva
authors.forename: G T
authors.initials: GT
authors.lastname: Sukhih
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000031:analogs & derivatives / Q000494:pharmacology; D000818:Animals; D000831:Animals, Newborn; D018891:Dentate Gyrus / Q000187:drug effects* / Q000503:physiopathology; D004791:Enzyme Inhibitors / Q000494:pharmacology; D020195:Epilepsy, Reflex / Q000188:drug therapy* / Q000235:genetics*; D005260:Female; D005838:Genotype; D008297:Male; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D055495:Neurogenesis / Q000187:drug effects* / Q000502:physiology; D018696:Neuroprotective Agents / Q000494:pharmacology; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors; D010446:Peptide Fragments / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000188:drug therapy / Q000235:genetics; D012720:Severity of Illness Index; D013045:Species Specificity; D013997:Time Factors
chemical_list: D004791:Enzyme Inhibitors; D018696:Neuroprotective Agents; D010446:Peptide Fragments; C048487:ACTH (4-7), Pro-Gly-Pro-; D000324:Adrenocorticotropic Hormone; D019001:Nitric Oxide Synthase; D019331:NG-Nitroarginine Methyl Ester