title: Single-nucleotide polymorphisms and expression of IL23R in Chinese ankylosing spondylitis patients.
abstract: The aim of this study was to investigate the association of single-nucleotide polymorphisms (SNPs) in IL23R with ankylosing spondylitis (AS) in Chinese Han population. Six SNPs were selected for analysis in AS patients and controls. The IL23R mRNA expression was detected using RT-PCR. The differences in the genotypes of rs11209032 and the differences in the genotypes and allele frequencies of rs6677188 between cases and controls were significant. The two SNPs rs11209032 and rs6677188 were in strong linkage disequilibrium. Haplotype analysis noted a higher proportion of GAC in cases and a higher proportion of GTC in controls. The patients with AS showed an elevated level of IL23R mRNA in PBMCs. This study suggested that IL23R polymorphisms were associated with susceptibility to AS in the Chinese population and that IL23R may be involved in the development of AS.
authors.affiliation: Department of Rheumatology, Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Road, Guangzhou, 510630, People's Republic of China.
authors.forename: Xinwei
authors.initials: X
authors.lastname: Wang
authors.forename: Jinxian
authors.initials: J
authors.lastname: Huang
authors.forename: Zhiming
authors.initials: Z
authors.lastname: Lin
authors.forename: Zetao
authors.initials: Z
authors.lastname: Liao
authors.forename: Chao
authors.initials: C
authors.lastname: Li
authors.forename: Qiujing
authors.initials: Q
authors.lastname: Wei
authors.forename: Yingjuan
authors.initials: Y
authors.lastname: Jiang
authors.forename: Like
authors.initials: L
authors.lastname: Zhao
authors.forename: Jieruo
authors.initials: J
authors.lastname: Gu
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics; D001483:Base Sequence / Q000235:genetics; D015415:Biomarkers / Q000032:analysis / Q000097:blood; D002681:China; D004252:DNA Mutational Analysis; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics*; D005820:Genetic Testing; D005838:Genotype; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D053760:Interleukin-23 Subunit p19 / Q000235:genetics; D015810:Linkage Disequilibrium / Q000235:genetics; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012333:RNA, Messenger / Q000378:metabolism; D018123:Receptors, Interleukin / Q000235:genetics*; D013167:Spondylitis, Ankylosing / Q000208:ethnology / Q000235:genetics* / Q000276:immunology*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D005819:Genetic Markers; C508840:IL23A protein, human; C515500:IL23R protein, human; D053760:Interleukin-23 Subunit p19; D012333:RNA, Messenger; D018123:Receptors, Interleukin
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