Telomere-mediated effects on melanogenesis and skin aging.
UV-induced melanogenesis (tanning) and "premature aging" or photoaging result in large part from DNA damage. This article reviews data tying both phenomena to telomere-based DNA damage signaling and develops a conceptual framework in which both responses may be understood as cancer-avoidance protective mechanisms.Journal of Investigative Dermatology Symposium Proceedings (2009) 14, 25-31; doi:10.1038/jidsymp.2009.9.
Gilchrest
Barbara A
BA
Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts, USA. bgilchre@bu.edu
Eller
Mark S
MS
Yaar
Mina
M
D000818:Animals; D001483:Base Sequence; D016922:Cellular Senescence; D004249:DNA Damage; D004260:DNA Repair; D006801:Humans; D008543:Melanins / Q000096:biosynthesis*; D008954:Models, Biological; D009838:Oligodeoxyribonucleotides / Q000235:genetics / Q000494:pharmacology; D015398:Signal Transduction; D015595:Skin Aging / Q000235:genetics / Q000502:physiology* / Q000528:radiation effects*; D055107:Suntan / Q000235:genetics / Q000502:physiology* / Q000528:radiation effects*; D016615:Telomere / Q000235:genetics / Q000502:physiology* / Q000528:radiation effects*; D014466:Ultraviolet Rays / Q000009:adverse effects
D008543:Melanins; D009838:Oligodeoxyribonucleotides