title: The Impact of HIV and Malaria Coinfection: What Is Known and Suggested Venues for Further Study.
abstract: HIV and malaria have similar global distributions. Annually, 500 million are infected and 1 million die because of malaria. 33 million have HIV and 2 million die from it each year. Minor effects of one infection on the disease course or outcome for the other would significantly impact public health because of the sheer number of people at risk for coinfection. While early population-based studies showed no difference in outcomes between HIV-positive and HIV-negative individuals with malaria, more recent work suggests that those with HIV have more frequent episodes of symptomatic malaria and that malaria increases HIV plasma viral load and decreases CD4+ T cells. HIV and malaria each interact with the host's immune system, resulting in a complex activation of immune cells, and subsequent dysregulated production of cytokines and antibodies. Further investigation of these interactions is needed to better define effects of coinfection.
authors.affiliation: Department of Medicine, Division of Infectious Diseases, Montefiore Medical Center, Albert Einstein College of Medicine, Ullmann 1205, 1300 Morris Park Avenue, Bronx, NY 10461, USA.
authors.forename: Sarah
authors.initials: S
authors.lastname: Hochman
authors.forename: Kami
authors.initials: K
authors.lastname: Kim
references.citation: Parasitol Today. 2000 Nov;16(11):469-76
references.pmid: 11063857
references.citation: J Investig Med. 2003 May;51(3):128-40
references.pmid: 12769195
references.citation: J Neurosci. 2006 Jan 25;26(4):1098-106
references.pmid: 16436595
references.citation: Lancet. 2005 Jan 15-21;365(9455):233-40
references.pmid: 15652606
references.citation: J Acquir Immune Defic Syndr. 2004 Mar 1;35(3):223-32
references.pmid: 15076236
references.citation: Pediatr Infect Dis J. 1997 Sep;16(9):876-81
references.pmid: 9306483
references.citation: J Infect Dis. 2006 Jul 15;194(2):198-207
references.pmid: 16779726
references.citation: Antimicrob Agents Chemother. 2005 Jul;49(7):2983-5
references.pmid: 15980379
references.citation: Infect Immun. 2004 Oct;72(10):5630-7
references.pmid: 15385460
references.citation: Exp Parasitol. 1995 Feb;80(1):54-63
references.pmid: 7821411
references.citation: Infect Immun. 2000 Jul;68(7):4135-44
references.pmid: 10858230
references.citation: Parasitol Int. 2006 Jun;55(2):107-12
references.pmid: 16388977
references.citation: AIDS. 2003 Mar 7;17(4):595-603
references.pmid: 12598780
references.citation: AIDS. 1999 Mar 11;13(4):487-94
references.pmid: 10197377
references.citation: J Immunol. 2005 May 15;174(10):5921-5
references.pmid: 15879082
references.citation: Int J Parasitol. 1996 Jun;26(6):647-55
references.pmid: 8875310
references.citation: Clin Infect Dis. 2005 Dec 1;41(11):1631-7
references.pmid: 16267737
references.citation: Am J Trop Med Hyg. 1999 May;60(5):733-7
references.pmid: 10344643
references.citation: J Thromb Haemost. 2007 Jan;5(1):155-65
references.pmid: 17002660
references.citation: J Acquir Immune Defic Syndr. 2006 Nov 1;43(3):363-7
references.pmid: 17079994
references.citation: Blood. 2007 Nov 1;110(9):3426-35
references.pmid: 17693580
references.citation: Am J Trop Med Hyg. 2009 Jan;80(1):119-25
references.pmid: 19141849
references.citation: Trends Immunol. 2003 Sep;24(9):491-9
references.pmid: 12967673
references.citation: J Acquir Immune Defic Syndr. 2005 Mar 1;38(3):310-3
references.pmid: 15735450
references.citation: J Immunol. 2006 Jan 1;176(1):441-50
references.pmid: 16365437
references.citation: Lancet. 2006 Apr 15;367(9518):1256-61
references.pmid: 16631881
references.citation: Antimicrob Agents Chemother. 2007 Feb;51(2):759-62
references.pmid: 17088482
references.citation: Virology. 2009 Mar 1;385(1):126-33
references.pmid: 19135225
references.citation: PLoS Med. 2007 May;4(5):e181
references.pmid: 17535103
references.citation: AIDS. 2004 Feb 20;18(3):547-54
references.pmid: 15090809
references.citation: Am J Trop Med Hyg. 2000 Jan;62(1):38-44
references.pmid: 10761722
references.citation: AIDS. 2008 Mar 30;22(6):785-7
references.pmid: 18356610
references.citation: Antimicrob Agents Chemother. 2006 Feb;50(2):639-48
references.pmid: 16436721
references.citation: Immunol Today. 1993 Mar;14(3):107-11
references.pmid: 8096699
references.citation: Microcirculation. 2008 Feb;15(2):81-107
references.pmid: 18260002
references.citation: Emerg Infect Dis. 2005 Sep;11(9):1410-9
references.pmid: 16229771
references.citation: Clin Vaccine Immunol. 2008 Apr;15(4):617-21
references.pmid: 18199738
references.citation: J Dev Behav Pediatr. 2002 Oct;23(5):353-64
references.pmid: 12394524
references.citation: J Infect Dis. 2006 Jan 1;193(1):9-15
references.pmid: 16323126
references.citation: J Infect Dis. 2009 Jan 1;199(1):134-41
references.pmid: 19032102
references.citation: Am J Trop Med Hyg. 2003 Oct;69(4):447-9
references.pmid: 14640507
references.citation: Int J Parasitol. 2006 May 1;36(5):555-68
references.pmid: 16616145
references.citation: J Pathol. 2008 Jan;214(2):231-41
references.pmid: 18161758
references.citation: Am J Trop Med Hyg. 2001 Mar-Apr;64(3-4):207-13
references.pmid: 11442219
references.citation: J Immunol. 1993 Nov 1;151(9):4811-20
references.pmid: 8409439
references.citation: Emerg Infect Dis. 2004 Apr;10(4):643-52
references.pmid: 15200854
references.citation: Pediatr Infect Dis J. 2003 Dec;22(12):1057-63
references.pmid: 14688565
references.citation: Int J Epidemiol. 1998 Apr;27(2):296-301
references.pmid: 9602413
references.citation: Lancet. 2003 Sep 27;362(9389):1039-41
references.pmid: 14522535
references.citation: AIDS. 2006 Jan 9;20(2):275-80
references.pmid: 16511422
references.citation: Infect Immun. 2009 May;77(5):1917-23
references.pmid: 19223480
references.citation: Nature. 1999 Jul 1;400(6739):73-7
references.pmid: 10403251
references.citation: J Virol. 2008 Aug;82(15):7591-600
references.pmid: 18508884
references.citation: Eur J Immunol. 1997 Jul;27(7):1719-25
references.pmid: 9247583
references.citation: J Leukoc Biol. 2000 Sep;68(3):383-90
references.pmid: 10985255
references.citation: J Infect Dis. 2004 Dec 1;190(11):1998-2000
references.pmid: 15529265
references.citation: Lancet. 2000 Sep 23;356(9235):1051-6
references.pmid: 11009139
references.citation: Br J Haematol. 1980 Oct;46(2):171-83
references.pmid: 7000157
references.citation: J Neuroimmune Pharmacol. 2006 Jun;1(2):160-81
references.pmid: 18040782
references.citation: Clin Lab Haematol. 1988;10(1):33-40
references.pmid: 3284694
references.citation: J Acquir Immune Defic Syndr. 2006 Jan 1;41(1):129-30
references.pmid: 16340488