Antinociceptive and anti-inflammatory activities of iridoid glycosides extract of Lamiophlomis rotata (Benth.) Kudo.
Lamiophlomis rotata (Benth.) Kudo is a perennial herb (Labiatae) used as the Tibetan traditional medicine with the effects of alleviating pain, detumescence, hemostasis, promoting blood circulation to remove blood stasis and reinforcing marrow. In this study, we investigated the antinociceptive and anti-inflammatory activities of iridoid glycosides extract of L. rotata (IGLR) in mice. Our results showed that the iridoid glycosides extract could decrease acetic-acid-induced writhings times and formalin-induced lickings times, inhibit carrageenan-induced hind paw edema and xylene-induced ear swelling, and suppress peritoneal capillary permeability and leukocyte infiltration also induced by acetic acid in mice. All of these results suggested that the iridoid glycosides extract possesses the significant antinociceptive and anti-inflammatory activities.
Li
Maoxing
M
Department of Pharmacy, Lanzhou General Hospital of PLA, Lanzhou, PR China. limaox2005@yahoo.com.cn
Shang
Xiaofei
X
Zhang
Ruxue
R
Jia
Zhengping
Z
Fan
Pengcheng
P
Ying
Qiang
Q
Wei
Lili
L
D019342:Acetic Acid; D000700:Analgesics / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001522:Behavior, Animal / Q000187:drug effects; D002199:Capillary Permeability / Q000187:drug effects; D004427:Ear Diseases / Q000139:chemically induced / Q000188:drug therapy; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D005557:Formaldehyde; D006027:Glycosides / Q000494:pharmacology / Q000627:therapeutic use*; D039823:Iridoids / Q000494:pharmacology / Q000627:therapeutic use*; D019686:Lamiaceae / Q000737:chemistry*; D051379:Mice; D008807:Mice, Inbred BALB C; D020556:Neutrophil Infiltration / Q000187:drug effects; D010146:Pain / Q000188:drug therapy; D010529:Peritoneal Cavity; D008517:Phytotherapy; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D014992:Xylenes
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D006027:Glycosides; D039823:Iridoids; D010936:Plant Extracts; D014992:Xylenes; D005557:Formaldehyde; D019342:Acetic Acid