title: [Differential aspects in children and adult patients with medulloblastoma].
abstract: OBJECTIVE
  Medulloblastoma is the more frequent malignant cerebral tumor in childhood.
  
  
  METHODS
  This is an observational study of a retrospective cohort in which there were included all the patients diagnosed of medulloblastoma in the last 19 years (1989-2007) in Hospital de Cruces of Baracaldo, Vizcaya, Spain.
  
  
  RESULTS
  There were included 37 patients, 20 men and 17 women, with ages between 1 and 48 years (average age 13.7 years with standard deviation 11.4). Tumor site and mortality according to initial dissemination were variables of statistic significance. Metastases were detected at diagnosis in two patients. The surgical resection was total in 75% of the patients. A relapse was diagnosed in the follow-up in 59.5% of the patients, with a positive spinal fluid in 27%. Sequelae were detected in 100% of the survivors, mainly with cerebellar and ocular alterations. One patient developed a meningioma and a maxillary sarcoma at the long term follow-up. It is important to emphasize the aggressiveness of medulloblastoma in both children and adults, with a global mortality of 56.8% and 48,6% at 5 years.
  
  
  CONCLUSIONS
  It is considered necessary a multidisciplinary treatment and a long term monitoring of the patients and the sequelae of the survivors, including the possibility of second tumours.
authors.affiliation: Unidad de Oncohematología Pediátrica, Hospital de Cruces, Baracaldo, Vizcaya, Spain.
authors.forename: Zuriñe
authors.initials: Z
authors.lastname: García Casales
authors.forename: Aizpea
authors.initials: A
authors.lastname: Echebarría Barona
authors.forename: Alejandro
authors.initials: A
authors.lastname: Urberuaga Pascual
authors.forename: Itziar
authors.initials: I
authors.lastname: Astigarraga Aguirre
authors.forename: Juan José
authors.initials: JJ
authors.lastname: Burgos Bretones
authors.forename: Aurora
authors.initials: A
authors.lastname: Navajas Gutiérrez
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002528:Cerebellar Neoplasms / Q000453:epidemiology / Q000401:mortality / Q000601:surgery; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D016001:Confidence Intervals; D003627:Data Interpretation, Statistical; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D008527:Medulloblastoma / Q000453:epidemiology / Q000401:mortality / Q000601:surgery; D008875:Middle Aged; D009362:Neoplasm Metastasis; D016011:Normal Distribution; D012189:Retrospective Studies; D013030:Spain / Q000453:epidemiology; D018709:Statistics, Nonparametric; D013997:Time Factors