An M-CSF receptor c-Fms antibody inhibits mechanical stress-induced root resorption during orthodontic tooth movement in mice.
OBJECTIVE
To examine the effect of anti-c-Fms antibody on odontoclastogenesis and root resorption in an orthodontic tooth movement mouse model.


METHODS
We used orthodontic tooth movement in which an Ni-Ti coil spring was inserted between the upper incisors and the upper first molar. Root resorption occurred in this model. Anti-c-Fms antibody was injected daily into a local site for 12 days during mechanical loading. Odontoclastogenesis and root resorption were assessed by histology and scanning electron microscopy.


RESULTS
The anti-c-Fms antibody significantly inhibited odontoclastogenesis and root resorption during orthodontic tooth movement.


CONCLUSIONS
M-CSF and/or its receptor is a potential therapeutic target in mechanical stress- induced odontoclastogenesis, and injection of an anti-c-Fms antibody might be useful for inhibition of mechanical stress-induced root resorption during orthodontic tooth movement.
Kitaura
Hideki
H
Divisions of Orthodontic and Dentofacial Orthopedics, Department of Translational Medicine, Course of Medical and Dental Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan. kitaura@net.nagasaki-u.ac.jp
Fujimura
Yuji
Y
Yoshimatsu
Masako
M
Eguchi
Toshiko
T
Kohara
Haruka
H
Jang
Insan
I
Morita
Yukiko
Y
Yoshida
Noriaki
N
D016301:Alveolar Bone Loss / Q000209:etiology / Q000517:prevention & control; D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology* / Q000627:therapeutic use; D003799:Dental Stress Analysis; D007074:Immunoglobulin G / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010010:Osteoclasts / Q000187:drug effects*; D016186:Receptor, Macrophage Colony-Stimulating Factor / Q000037:antagonists & inhibitors*; D012391:Root Resorption / Q000209:etiology / Q000517:prevention & control*; D014087:Tooth Movement Techniques / Q000009:adverse effects*
D000911:Antibodies, Monoclonal; D007074:Immunoglobulin G; D016186:Receptor, Macrophage Colony-Stimulating Factor