Amoxicillin-clavulanic acid-induced linear immunoglobulin A bullous dermatosis: case report and review of the literature.
BACKGROUND
Linear immunoglobulin A bullous dermatosis (LABD) is an autoimmune subepidermal blistering disease, rarely induced by drugs.


METHODS
We describe a case of a 47-year-old man who developed a severe blistering eruption after therapy with amoxicillin-clavulanic acid.


RESULTS
Histopathologic examination and direct immunofluorescence were consistent with a diagnosis of LABD. Therapy with dapsone controlled the disease but, after sun exposure, there was a worsening of the illness.


CONCLUSIONS
To our knowledge, this is the first case of amoxicillin-clavulanic acid-induced LABD in an adult.
Panasiti
Vincenzo
V
Department of Dermatology, University of Rome La Sapienza, Rome, Italy. ilcapo75@gmx.net
Rossi
Mariarita
M
Devirgiliis
Valeria
V
Curzio
Michela
M
Bottoni
Ugo
U
Calvieri
Stefano
S
D019980:Amoxicillin-Potassium Clavulanate Combination / Q000009:adverse effects*; D006801:Humans; D007070:Immunoglobulin A; D008297:Male; D008875:Middle Aged; D012872:Skin Diseases, Vesiculobullous / Q000139:chemically induced* / Q000276:immunology*
D007070:Immunoglobulin A; D019980:Amoxicillin-Potassium Clavulanate Combination