title: Coagulation and anticoagulation in pulmonary arterial hypertension.
abstract: Pulmonary arterial hypertension is a complex pulmonary vascular disease with a broad range of abnormal vascular abnormalities. Vasoconstriction, remodeling and thrombosis contribute to some extent to increased pulmonary vascular resistance and pressure. This review presents current knowledge on the role of the thrombotic process in the pathogenesis of PAH and evaluates the rationale for anticoagulation therapy.
authors.affiliation: Division for Pulmonary Medicine, Rambam Health Care Campus, Haifa, Israel. g_berger@rambam.health.gov.il
authors.forename: Gidon
authors.initials: G
authors.lastname: Berger
authors.forename: Zaher S
authors.initials: ZS
authors.lastname: Azzam
authors.forename: Ron
authors.initials: R
authors.lastname: Hoffman
authors.forename: Mordechai
authors.initials: M
authors.lastname: Yigla
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use*; D001777:Blood Coagulation; D001792:Blood Platelets / Q000502:physiology; D004730:Endothelium, Vascular / Q000503:physiopathology; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D013923:Thromboembolism / Q000188:drug therapy*; D014661:Vasoconstriction
chemical_list: D000925:Anticoagulants