Determination of the performance characteristics of a new multi-residue method for non-steroidal anti-inflammatory drugs, corticosteroids and anabolic steroids in food animal tissues.
A new LC-MS/MS method was developed for the analysis of 29 veterinary drug residues, spanning three different drug classes, in animal tissues. The procedures used to measure the characteristic performance parameters of the method and the results obtained using fortified blank bovine muscle and kidney tissue are described. For a quantitative and confirmatory method, the characteristic performance parameters to be determined are the limits of quantification, trueness, recovery, precision, selectivity, ruggedness, and stability. The characteristic performance parameters defined for the method will be verified during a validation study by an independent experienced analyst to determine whether the method is suitable for use in a regulatory monitoring and control program for residues of the 29 analytes.
Chrusch
J
J
Centre for Veterinary Drug Residues, Saskatoon, Saskatchewan, Canada.
Lee
S
S
Fedeniuk
R
R
Boison
J O
JO
D045930:Anabolic Agents / Q000032:analysis; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000032:analysis; D002417:Cattle; D002853:Chromatography, Liquid / Q000379:methods; D004350:Drug Residues / Q000032:analysis*; D004355:Drug Stability; D005504:Food Analysis / Q000379:methods; D005506:Food Contamination / Q000032:analysis*; D005938:Glucocorticoids / Q000032:analysis; D007668:Kidney / Q000737:chemistry; D008460:Meat / Q000032:analysis*; D018482:Muscle, Skeletal / Q000737:chemistry; D015203:Reproducibility of Results; D053719:Tandem Mass Spectrometry / Q000379:methods; D019155:Veterinary Drugs / Q000032:analysis*
D045930:Anabolic Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D005938:Glucocorticoids; D019155:Veterinary Drugs