Preparation and evaluation of 99mTc(CO)3-labeled pentadecanoic acid derivative and its suspension in lipiodol.
Abstract Transarterial embolization by the intra-arterial administration of 131I-lipiodol is a modality used in the treatment of liver cancer. Long-chain fatty acids, being highly lipophilic, are also known to localize in the liver, thus constituting favorable vectors for this modality of treatment. Toward this, we envisaged the derivatization of 15-bromopentadecanoic acid, rendering it suitable for incorporation of a tridentate chelating moiety, for radiolabeling with the [99mTc(CO)3(H2O)3]+ precursor. The complex prepared, being lipophilic, was expected to behave as a lipiodol surrogate. The radiolabeled complex could be obtained in >95% radiochemical yield, as characterized by high-performance liquid chromatography. The intravenous injection of the radiolabeled complex in mice resulted in 23.5% +/- 4.3% uptake of injected dose (ID) organ in the liver at 3 hours postinjection. However, the uptake of the lipiodol suspension of the complex at 3 hours postinjection in the liver was found to be 43.8 +/- 13.4% ID/organ, when injected via the portal vein.
Satpati
Drishty
D
Radiopharmaceuticals Division, Bhabha Atomic Research Center, Mumbai, India.
Pandey
Usha
U
Sarma
H D
HD
Venkatesh
Meera
M
Banerjee
Sharmila
S
D000818:Animals; D005227:Fatty Acids / Q000737:chemistry / Q000493:pharmacokinetics; D007457:Iodine Radioisotopes / Q000737:chemistry; D007459:Iodized Oil / Q000737:chemistry* / Q000493:pharmacokinetics; D008099:Liver / Q000378:metabolism; D019275:Radiopharmaceuticals / Q000737:chemistry* / Q000493:pharmacokinetics; D051381:Rats; D017208:Rats, Wistar; D017556:Technetium Compounds / Q000737:chemistry* / Q000493:pharmacokinetics; D014018:Tissue Distribution
D005227:Fatty Acids; D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D017556:Technetium Compounds; D007459:Iodized Oil; C117025:pentadecanoic acid