title: In vivo assessment of blood flow patterns in abdominal aorta of mice with MRI: implications for AAA localization.
abstract: Abdominal aortic aneurysms (AAA) localize in the infrarenal aorta in humans, while they are found in the suprarenal aorta in mouse models. It has been shown previously that humans experience a reversal of flow during early diastole in the infrarenal aorta during each cardiac cycle. This flow reversal causes oscillatory wall shear stress (OWSS) to be present in the infrarenal aorta of humans. OWSS has been linked to a variety of proatherogenic and proinflammatory factors. The presence of reverse flow in the mouse aorta is unknown. In this study we investigated blood flow in mice, using phase-contrast magnetic resonance (PCMR) imaging. We measured blood flow in the suprarenal and infrarenal abdominal aorta of 18 wild-type C57BL/6J mice and 15 apolipoprotein E (apoE)-/- mice. Although OWSS was not directly evaluated, results indicate that, unlike humans, there is no reversal of flow in the infrarenal aorta of wild-type or apoE-/- mice. Distensibility of the mouse aortic wall in both the suprarenal and infrarenal segments is higher than reported values for the human aorta. We conclude that normal mice do not experience the reverse flow in the infrarenal aorta that is observed in humans.
authors.affiliation: Department of Radiology, Emory University School of Medicine, Georgia Institute of Technology, Atlanta, Georgia 30322, USA. smbat_amirbekian@yahoo.com
authors.forename: Smbat
authors.initials: S
authors.lastname: Amirbekian
authors.forename: Robert C
authors.initials: RC
authors.lastname: Long
authors.forename: Michelle A
authors.initials: MA
authors.lastname: Consolini
authors.forename: Jin
authors.initials: J
authors.lastname: Suo
authors.forename: Nick J
authors.initials: NJ
authors.lastname: Willett
authors.forename: Sam W
authors.initials: SW
authors.lastname: Fielden
authors.forename: Don P
authors.initials: DP
authors.lastname: Giddens
authors.forename: W Robert
authors.initials: WR
authors.lastname: Taylor
authors.forename: John N
authors.initials: JN
authors.lastname: Oshinski
mesh_terms: D000818:Animals; D001012:Aorta, Abdominal / Q000033:anatomy & histology / Q000502:physiology*; D017544:Aortic Aneurysm, Abdominal / Q000473:pathology / Q000503:physiopathology*; D001057:Apolipoproteins E / Q000172:deficiency / Q000235:genetics; D001783:Blood Flow Velocity; D002932:Cineangiography; D004548:Elasticity; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D018810:Magnetic Resonance Angiography; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D011673:Pulsatile Flow; D012039:Regional Blood Flow; D015203:Reproducibility of Results; D013045:Species Specificity; D013314:Stress, Mechanical
chemical_list: D001057:Apolipoproteins E
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