Venom-sweet-venom: N-linked glycosylation in snake venom toxins.
Protein glycosylation represents one of the most important post-translational events, and is a mean of diversifying a protein without recourse to the genome. The venoms produced by snakes contain an abundance of glycoproteins with N-linked carbohydrates. N-linked glycosylation can ensure the correct folding of important functional domains. Characterization of carbohydrates structures aids in development of human therapeutics by snake venom toxins.
Soares
Sandro G
SG
Departamento de Biologia Celular e Molecular e Bioagentes Patogênicos, Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo, FMRP-USP, Ribeirão Preto, SP, Brasil.
Oliveira
Leandro L
LL
D000595:Amino Acid Sequence; D000818:Animals; D006023:Glycoproteins / Q000737:chemistry*; D006031:Glycosylation; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D030162:Reptilian Proteins / Q000737:chemistry*; D016415:Sequence Alignment; D012697:Serine Endopeptidases / Q000737:chemistry; D012910:Snake Venoms / Q000737:chemistry* / Q000201:enzymology; D012911:Snakes
D006023:Glycoproteins; D030162:Reptilian Proteins; D012910:Snake Venoms; D012697:Serine Endopeptidases