On the origin of event-related potentials indexing covert attentional selection during visual search.
Despite nearly a century of electrophysiological studies recording extracranially from humans and intracranially from monkeys, the neural generators of nearly all human event-related potentials (ERPs) have not been definitively localized. We recorded an attention-related ERP component, known as the N2pc, simultaneously with intracranial spikes and local field potentials (LFPs) in macaques to test the hypothesis that an attentional-control structure, the frontal eye field (FEF), contributed to the generation of the macaque homologue of the N2pc (m-N2pc). While macaques performed a difficult visual search task, the search target was selected earliest by spikes from single FEF neurons, later by FEF LFPs, and latest by the m-N2pc. This neurochronometric comparison provides an empirical bridge connecting macaque and human experiments and a step toward localizing the neural generator of this important attention-related ERP component.
Cohen
Jeremiah Y
JY
Department of Psychology, Vanderbilt Vision Research Center, Center for Integrative and Cognitive Neuroscience, Vanderbilt Brain Institute, Vanderbilt University, Nashville, Tennessee 37240, USA.
Heitz
Richard P
RP
Schall
Jeffrey D
JD
Woodman
Geoffrey F
GF
D000200:Action Potentials; D000818:Animals; D001288:Attention / Q000502:physiology*; D004569:Electroencephalography; D005071:Evoked Potentials / Q000502:physiology*; D005625:Frontal Lobe / Q000502:physiology*; D008255:Macaca radiata; D008297:Male; D009474:Neurons / Q000502:physiology*; D009483:Neuropsychological Tests; D011930:Reaction Time; D013647:Task Performance and Analysis; D013997:Time Factors; D014793:Visual Cortex / Q000502:physiology*; D014796:Visual Perception / Q000502:physiology*
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