title: Chemical constituents of Baeckea frutescens leaves inhibit copper-induced low-density lipoprotein oxidation.
abstract: Oxidative modification of LDL plays an important role in the genesis of arteriosclerosis. This study focused on the effects of the leaves of Baeckea frutescens in the prevention of arteriosclerosis. The leaves of B. frutescens have afforded, besides known flavonoid and chromone glycosides, a novel biflavonoid glycoside, characterized as 3-O-alpha-L-rhamnopyranosylmyricetinyl-(I-2'',II-2'')-3-O-alpha-L-rhamnopyranosylmyricetin on the basis of chemical and spectral evidence. This compound exhibited marked inhibition of copper-induced LDL oxidation.
authors.affiliation: Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Minatojima, Chuo-ku, Kobe, Japan. kamiya@pharm.kobegakuin.ac.jp
authors.forename: Kohei
authors.initials: K
authors.lastname: Kamiya
authors.forename: Toshiko
authors.initials: T
authors.lastname: Satake
mesh_terms: D000704:Analysis of Variance; D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology*; D001161:Arteriosclerosis / Q000517:prevention & control; D008078:Cholesterol, LDL / Q000378:metabolism*; D002867:Chromones / Q000302:isolation & purification / Q000494:pharmacology; D003300:Copper; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D006027:Glycosides / Q000302:isolation & purification / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D027822:Myrtaceae / Q000737:chemistry*; D010084:Oxidation-Reduction / Q000187:drug effects; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves; D017392:Thiobarbituric Acid Reactive Substances
chemical_list: C551160:3-O-rhamnopyranosylmyricetinyl-(I-2',II-2')-3O-rhamnopyranosylmyricetin; D000975:Antioxidants; D008078:Cholesterol, LDL; D002867:Chromones; D005419:Flavonoids; D006027:Glycosides; D010936:Plant Extracts; D017392:Thiobarbituric Acid Reactive Substances; D003300:Copper