What can be learned from the history of recurrence in migraine? A comment.
Recurrence was first recognised as a clinical problem in 1989 with the advent of sumatriptan. The history of recurrence in early sumatriptan randomised clinical trials is described. Recurrence has been ascribed to patient-dependent factors but experience with ergot alkaloids suggested that recurrence can also be treatment-dependent. Possible mechanisms for recurrence are discussed.
Tfelt-Hansen
Peer
P
Danish Headache Centre, Department of Neurology, Glostrup Hospital, University of Copenhagen, Glostrup, Denmark. ptha@glo.regionh.dk
D002986:Clinical Trials as Topic; D006801:Humans; D008881:Migraine Disorders / Q000517:prevention & control*; D012008:Recurrence; D018170:Sumatriptan / Q000627:therapeutic use*; D014662:Vasoconstrictor Agents / Q000627:therapeutic use*
D014662:Vasoconstrictor Agents; D018170:Sumatriptan
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