Novel targets for immunotherapy in glomerulonephritis.
Glomerulonephritis is a common cause of chronic kidney disease and end stage renal failure. Current therapy relies on variably effective, nonspecific and toxic immunosuppression. Recent insights into underlying biology and disease pathogenesis in human glomerulonephritis combined with advances in the fields of inflammation and autoimmunity promise a cadre of novel targeted interventions. This review highlights the therapeutic potential of two antigens, alpha3 (IV)NC1 collagen and podocyte neutral endopeptidase, and two cell signaling and effector molecules, IgG Fc receptors and complement, judged to be particularly amenable to therapeutic manipulation in man. It is anticipated that continued dissection of pathogenesis in the diverse disorders that comprise the glomerulonephritides will provide the basis for individualized disease-specific therapy.
Foster
Mary H
MH
Department of Medicine and Research Service, Duke University Medical Center and Durham Veterans Affairs Medical Center, Durham, North Carolina, USA.
Eur J Immunol. 2001 Apr;31(4):1255-60
11298352
Am J Physiol Renal Physiol. 2005 Oct;289(4):F660-71
16159900
J Immunol. 2004 Sep 1;173(5):3542-8
15322219
Nat Genet. 2002 Aug;31(4):424-8
12091909
J Exp Med. 1992 Apr 1;175(4):939-50
1532415
Science. 2005 Jan 28;307(5709):590-3
15681388
JAMA. 2007 Nov 7;298(17):2038-47
17986697
J Immunol. 2005 May 1;174(9):5750-7
15843577
J Immunol. 1994 Aug 1;153(3):1281-92
8027555
J Nephrol. 2006 Nov-Dec;19(6):699-705
17173240
Eur J Immunol. 2002 Sep;32(9):2672-9
12207352
J Immunol. 2005 Mar 15;174(6):3247-55
15749855
Adv Immunol. 2007;96:179-204
17981207
Hum Immunol. 2005 Apr;66(4):395-402
15866703
Mol Immunol. 2003 Sep;40(2-4):159-70
12914822
J Exp Med. 2000 Mar 6;191(5):899-906
10704470
Semin Nephrol. 2007 Jan;27(1):47-58
17336688
Curr Drug Targets Inflamm Allergy. 2005 Jun;4(3):353-62
16101545
J Immunol. 2002 Jun 1;168(11):5943-53
12023401
Mol Immunol. 2006 Jan;43(1-2):97-106
16026839
N Engl J Med. 2002 Jul 11;347(2):103-9
12110738
Hum Mol Genet. 2005 Oct 1;14(19):2881-92
16115811
Kidney Int. 1995 Jun;47(6):1604-14
7643529
Eur J Immunol. 2000 Apr;30(4):1182-90
10760808
J Nephrol. 2007 May-Jun;20(3):268-87
17557260
Kidney Int. 2002 Dec;62(6):2087-96
12427132
Exp Clin Transplant. 2005 Jun;3(1):283-8
15989671
Mol Immunol. 2007 Jan;44(1-3):139-46
16887189
J Am Soc Nephrol. 2005 May;16(5):1350-9
15814836
Transplantation. 2000 Feb 27;69(4):679-83
10708133
Proc Natl Acad Sci U S A. 1996 Aug 6;93(16):8563-8
8710910
J Clin Invest. 2003 Jun;111(12):1875-85
12813023
Kidney Int Suppl. 2005 Sep;(98):S1-6
16108963
Arthritis Rheum. 2001 Feb;44(2):432-41
11229475
Exp Nephrol. 1996 Jul-Aug;4(4):205-12
8864724
J Autoimmun. 2007 Aug;29(1):30-7
17459659
J Am Soc Nephrol. 2007 Sep;18(9):2447-56
17675665
Eur J Immunol. 2005 Aug;35(8):2496-506
16052609
J Immunol. 2002 Feb 1;168(3):1036-41
11801636
J Clin Invest. 1998 Sep 15;102(6):1229-38
9739057
Kidney Int. 1998 Nov;54(5):1542-9
9844130
Semin Immunopathol. 2007 Nov;29(4):445-58
17899086
N Engl J Med. 2003 Jun 19;348(25):2543-56
12815141
Lancet. 1999 May 1;353(9163):1509-15
10232333
Lancet. 2004 Oct 2-8;364(9441):1252-9
15464186
Nat Genet. 1998 May;19(1):56-9
9590289
J Immunol. 2001 May 15;166(10):6444-51
11342671
J Am Soc Nephrol. 1995 Jul;6(1):35-47
7579068
J Immunol. 2004 Nov 1;173(9):5835-42
15494537
J Immunol. 2000 Jan 15;164(2):786-94
10623824
Nephrol Dial Transplant. 2006 Sep;21(9):2378-9
16864599
J Biol Chem. 2002 Oct 18;277(42):40075-83
12193605
J Immunol. 2005 Oct 15;175(8):5516-23
16210660
J Am Soc Nephrol. 2003 Mar;14(3):670-9
12595503
J Am Soc Nephrol. 2003 Sep;14(9):2271-9
12937303
Mol Immunol. 2004 Nov;41(11):1089-98
15476920
J Immunol. 2004 Feb 15;172(4):2636-42
14764738
Adv Nephrol Necker Hosp. 1994;23:91-131
8154367
J Biol Chem. 1988 Sep 15;263(26):13374-80
3417661
Nature. 2006 Feb 16;439(7078):851-5
16482158
J Am Soc Nephrol. 2001 Jan;12(1):61-70
11134251
Xenotransplantation. 2006 Mar;13(2):108-10
16623802
Kidney Int. 1998 Feb;53(2):402-7
9461099
J Biol Chem. 2000 Jun 30;275(26):20027-32
10748075
Nat Med. 2005 Oct;11(10):1056-8
16170323
Nat Genet. 2007 Jun;39(6):721-3
17529978
J Immunol. 2005 Dec 1;175(11):7728-37
16301683
J Biol Chem. 1999 Apr 16;274(16):11267-74
10196215
Ann N Y Acad Sci. 2007 Sep;1110:559-66
17911472
J Am Soc Nephrol. 2004 Mar;15(3):787-95
14978182
J Pediatr. 1980 Apr;96(4):697-9
7359277
Appl Pathol. 1989;7(2):85-98
2567175
J Clin Invest. 1978 Dec;62(6):1275-87
372233
Arthritis Rheum. 2003 Feb;48(2):442-54
12571854
Rheumatology (Oxford). 2007 Sep;46(9):1433-7
17686790
N Engl J Med. 2002 Jun 27;346(26):2053-60
12087141
Am J Pathol. 1994 Apr;144(4):807-19
8160779
Arch Immunol Ther Exp (Warsz). 2006 Jan-Feb;54(1):1-13
16642252
Science. 2005 Dec 2;310(5753):1510-2
16322460
Lab Invest. 1978 Apr;38(4):502-10
147961
J Biol Chem. 2000 Feb 25;275(8):6030-7
10681598
Immunol Rev. 2007 Oct;219:157-66
17850488
Kidney Int. 2005 May;67(5):1692-703
15840015
Proc Natl Acad Sci U S A. 1984 Jun;81(12):3838-42
6328527
Autoimmun Rev. 2005 Nov;4(8):515-9
16214088
Kidney Int. 1998 Feb;53(2):331-49
9461093
Immunity. 2000 Aug;13(2):277-85
10981970
Immunity. 2005 Jul;23(1):41-51
16039578
J Exp Med. 2000 Nov 6;192(9):1339-52
11067882
Kidney Int. 1982 Apr;21(4):642-52
7047864
J Biol Chem. 1999 Sep 3;274(36):25862-8
10464328
Proc Natl Acad Sci U S A. 1994 Oct 11;91(21):9725-9
7937880
Rheum Dis Clin North Am. 2006 Feb;32(1):149-56, x
16504827
J Clin Invest. 1995 Mar;95(3):1054-61
7883953
J Exp Med. 2006 Mar 20;203(3):789-97
16520389
Immunity. 1998 Nov;9(5):721-31
9846493
Clin Exp Immunol. 1997 Dec;110(3):403-9
9409643
Science. 2006 Aug 4;313(5787):670-3
16888140
Springer Semin Immunopathol. 2003 May;24(4):345-61
12778332
J Biol Chem. 2001 Mar 2;276(9):6370-7
11098057
Proc Natl Acad Sci U S A. 1982 Sep;79(18):5557-61
6752952
Immunity. 2006 Jan;24(1):19-28
16413920
Kidney Int. 2004 Jan;65(1):129-38
14675043
Kidney Int. 1991 Sep;40(3):533-8
1787650
J Immunol. 2002 Jul 15;169(2):1126-34
12097422
Curr Opin Nephrol Hypertens. 2005 May;14(3):223-8
15821414
Kidney Int. 2003 Mar;63(3):826-34
12631063
J Biol Chem. 2005 Jul 22;280(29):27147-54
15917228
Science. 1998 Feb 13;279(5353):1052-4
9461440
Kidney Int. 2001 Jul;60(1):137-46
11422745
J Exp Med. 2006 Sep 4;203(9):2157-64
16923849
Proc Natl Acad Sci U S A. 2006 Jun 20;103(25):9649-54
16769899
Kidney Int. 2003 Oct;64(4):1406-16
12969160
J Immunol. 2002 Apr 1;168(7):3601-7
11907125
Annu Rev Immunol. 2001;19:275-90
11244038
J Immunol. 2002 Mar 1;168(5):2538-43
11859149
Nat Biotechnol. 2007 Nov;25(11):1265-75
17989689
J Clin Invest. 1997 Nov 1;100(9):2263-75
9410904
J Clin Invest. 1986 Apr;77(4):1096-107
3514672
Nat Med. 2006 Jun;12(6):682-7
16715088
Am J Pathol. 1987 Oct;129(1):183-91
2444109
J Am Soc Nephrol. 2005 Dec;16(12):3563-71
16236801