title: Fetuses with single umbilical artery: analysis of 45 cases.
abstract: OBJECTIVE
  The aim of this study was to analyze cases and determine the clinical significance of a prenatally detected single umbilical artery (SUA) in our population.
  
  
  METHODS
  All second and third trimester sonographic examinations carried out between January 2004 and September 2007 in our perinatology unit were reviewed. The postnatal results of the fetuses with SUA were obtained from the medical records and the patients.
  
  
  RESULTS
  From a total of 5,620 pregnant patients who were examined by ultrasound (US) scan between 15-36 weeks, a single umbilical artery was found in 45 cases, representing an incidence of 0.8%. Of these, 20 (45%) also presented with other malformations. There were six neonatal deaths, one fetal demise, and six terminations of pregnancy due to severe malformations in this group. Three cases with associated anomalies underwent surgery and one case required intensive care in the neonatal period. The only cytogenetic abnormality was trisomy 18 in one case. Six of 45 fetuses (13%) with single umbilical arteries had abnormal echocardiographic findings. In two of the fetuses associated anomalies (cleft palate and esophageal atresia) were detected after birth. In pregnancies without associated anomalies no aneuploidy was found and they were completely normal at birth and during the neonatal period.
  
  
  CONCLUSIONS
  Scanning the umbilical cord is one of the essential parts of US examination. As the rate of cardiac malformations seen with single umbilical arteries is high, fetal echocardiography should be performed in suspected cases. The newborn should be reexamined immediately after birth due to the possibility of undetected anomalies.
authors.affiliation: Department of Gynecology & Obstetrics, Haseki Training & Research Hospital, Division of Perinatology, Istanbul, Turkey.
authors.forename: B
authors.initials: B
authors.lastname: Dane
authors.forename: C
authors.initials: C
authors.lastname: Dane
authors.forename: M
authors.initials: M
authors.lastname: Kiray
authors.forename: A
authors.initials: A
authors.lastname: Cetin
authors.forename: M
authors.initials: M
authors.lastname: Yayla
mesh_terms: D000015:Abnormalities, Multiple / Q000000981:diagnostic imaging*; D004452:Echocardiography; D005260:Female; D006801:Humans; D011247:Pregnancy; D012189:Retrospective Studies; D016216:Ultrasonography, Prenatal; D014469:Umbilical Arteries / Q000002:abnormalities* / Q000000981:diagnostic imaging*