title: Only two ways to achieve perfection.
abstract: The functional repertoire of a network is determined by its topology. Ma et al. (2009) analyze enzyme networks with three nodes and take a reverse-engineering approach to ask how many core network topologies can establish perfect adaptation, the ability to reset after perturbation. Surprisingly, the answer is just two.
authors.affiliation: Department of Pharmacology, Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
authors.forename: Alexander B
authors.initials: AB
authors.lastname: Artyukhin
authors.forename: Lani F
authors.initials: LF
authors.lastname: Wu
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Altschuler
mesh_terms: D000222:Adaptation, Physiological; D003198:Computer Simulation; D004798:Enzymes / Q000502:physiology; D008954:Models, Biological
chemical_list: D004798:Enzymes