Elevated levels of numerous cytokines in drainage fluid after primary total hip arthroplasty.
As cytokines are involved in wound healing and other inflammatory processes, it could be valuable to measure their levels at the operative site. This study was conducted to investigate whether different cytokines are measurable in drainage fluid and, when measurable, whether we can find a difference in cytokine levels between one and six hours postoperatively. Samples from the drainage system in 30 consecutive patients undergoing primary total hip replacement were collected at one and six hours after closure of the wound. Levels of several cytokines were measured in the drainage fluids. A significant elevation of almost all cytokines was observed between the sample after one hour and six hours postoperatively. We found a strong correlation between the different pro-inflammatory cytokines. The IL-6 to IL-10 ratio were also raised, showing a pro-inflammatory predominance. Levels were much higher than those previously shown in serum.
van der Heide
Huub J L
HJ
Department of Orthopaedic Surgery, Radboud University Nijmegen Medical Centre, The Netherlands. h.j.l.van_der_heide@lumc.nl
van der Kraan
Peter M
PM
Rijnberg
Willard J
WJ
Buma
Pieter
P
Schreurs
B Willem
BW
D019644:Arthroplasty, Replacement, Hip; D001826:Body Fluids / Q000737:chemistry*; D016207:Cytokines / Q000032:analysis*; D004322:Drainage; D006801:Humans; D014945:Wound Healing / Q000502:physiology*
D016207:Cytokines
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