title: Rapid oscillatory activity in delta brushes of premature and term neonatal EEG.
abstract: We compared frequency and power of neonatal EEG delta brush rapid oscillatory activity (ROA) using multiple band frequency analysis (MBFA) in three groups; pre-term (PT, post-conceptional age 33-35.6 weeks, n=5); full-term (FT, 39.4-40.6 weeks, n=5) and pre-term or full-term with phenobarbital exposure (PB, n=5). Mean number of delta brushes analyzed was 29.4 (range 26-47) in PT, 20.8 (14-33) in FT and 20 (7-37) in PB. Mean frequency+/-standard deviation (s.d.) was 16.9+/-2.1 Hz (range 15-20 Hz) in PT, 17.3+/-1.9 Hz (15-20 Hz) in FT and 16.1+/-1.6 Hz (14-19 Hz) in PB. Mean power+/-s.d. was 22.9+/-6.2 microV(2) (range 16-39 microV(2)) in PT, 11.9+/-4.1 microV(2) (7-19 microV(2)) in FT and 17.1+/-6.2 microV(2) (9-26 microV(2)) in PB. Power was significantly higher in PT than FT (p<0.005). Power after merging PB into respective PT (PT', n=8) and FT (FT', n=7) groups, remained significantly higher in PT' (mean+/-s.d. 21.8+/-7.4 microV(2)) than FT' (11.4+/-3.6 microV(2)) (p<0.05). We characterise ROA in delta brushes in maturing neonates using MBFA, which may provide additional information for assessing future seizure recurrence and epilepsy risk.
authors.affiliation: Clinical Neurophysiology, Division of Neurology, The Hospital for Sick Children, Toronto, Ont, Canada.
authors.forename: Derrick W S
authors.initials: DW
authors.lastname: Chan
authors.forename: Madoka
authors.initials: M
authors.lastname: Yamazaki
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Akiyama
authors.forename: Bill
authors.initials: B
authors.lastname: Chu
authors.forename: Elizabeth J
authors.initials: EJ
authors.lastname: Donner
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Otsubo
mesh_terms: D000927:Anticonvulsants / Q000494:pharmacology; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D003700:Delta Rhythm; D004569:Electroencephalography; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000502:physiology*; D010507:Periodicity; D010634:Phenobarbital / Q000494:pharmacology; D012189:Retrospective Studies; D012815:Signal Processing, Computer-Assisted
chemical_list: D000927:Anticonvulsants; D010634:Phenobarbital