Potential therapeutic failure of generic vancomycin in a liver transplant patient with MRSA peritonitis and bacteremia.
We report a case of generic vancomycin treatment failure in a liver transplant patient with MRSA peritonitis and bacteremia, followed by a rapid sterilization of blood and peritoneal fluid after switching to the branded product. It raises concern about therapeutic equivalence of generic vancomycin.
Rodriguez
Carlos A
CA
GRIPE: Grupo Investigador de Problemas en Enfermedades Infecciosas, University of Antioquia Medical School, Medellín, Colombia.
Agudelo
Maria
M
Cataño
Juan C
JC
Zuluaga
Andres F
AF
Vesga
Omar
O
D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D016470:Bacteremia / Q000188:drug therapy*; D016568:Drugs, Generic / Q000627:therapeutic use; D006801:Humans; D016031:Liver Transplantation; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus; D008875:Middle Aged; D010538:Peritonitis / Q000188:drug therapy*; D013203:Staphylococcal Infections / Q000188:drug therapy*; D016896:Treatment Outcome; D014640:Vancomycin / Q000627:therapeutic use*
D000900:Anti-Bacterial Agents; D016568:Drugs, Generic; D014640:Vancomycin