The Short-Form Six-Dimension utility index predicted mortality in the European Prospective Investigation into Cancer-Norfolk prospective population-based study.
OBJECTIVE
To examine the relationship between the Short-Form Six-Dimension (SF-6D) and mortality.


METHODS
Participants were 17,736 men and women aged 40-79 years at baseline who lived in Norfolk, UK, and had no known cardiovascular disease or cancer, and completed the anglicized Short-Form 36 (SF-36)-item during 1996-2000 in the European Prospective Investigation into Cancer-Norfolk prospective population study. The SF-36 data were converted to SF-6D. The relationship between SF-6D and all-cause and cause-specific mortality were examined.


RESULTS
One thousand and seventy deaths occurred during a total of 115,255 person years of follow-up (mean 6.5 years). Lower SF-6D was associated with increased risk of all-cause mortality in men and women. A decrease of 1 standard deviation (0.12 point) in SF-6D was associated with a 35% increase in all-cause mortality (hazards ratio = 1.35; 95% CI: 1.26, 1.45) after controlling for age, gender, body mass index, systolic blood pressure, cholesterol, diabetes, smoking, and social class. Similar results were observed for cardiovascular, cancer, and other causes of deaths.


CONCLUSIONS
Poor health utility measured by the SF-6D predicted increased risk of all-cause and cause-specific mortality in men and women. The present study provides the first evidence of the sensitivity of the SF-6D in predicting mortality in an apparently healthy population.
Myint
Phyo K
PK
Ageing and Stroke Medicine Section, Health & Social Sciences Research Institute, School of Medicine, Health Policy and Practice, University of East Anglia, Chancellors Drive, Norwich, Norfolk NR4 7TJ, UK. Phyo.K.Myint@uea.ac.uk
Smith
Richard D
RD
Luben
Robert N
RN
Surtees
Paul G
PG
Wainwright
Nicholas W J
NW
Wareham
Nicholas J
NJ
Bingham
Sheila A
SA
Khaw
Kay-Tee
KT
D000328:Adult; D000368:Aged; D002318:Cardiovascular Diseases / Q000401:mortality; D004739:England / Q000453:epidemiology; D005260:Female; D006305:Health Status Indicators; D006801:Humans; D008297:Male; D008875:Middle Aged; D009026:Mortality; D009369:Neoplasms / Q000401:mortality; D011379:Prognosis; D011446:Prospective Studies; D011788:Quality of Life; D012907:Smoking / Q000401:mortality; D012923:Social Class