Clamping down on transposon targeting.
The sliding beta clamp subunit of the DNA replication machinery in the bacterium Escherichia coli coordinates multiple functions in the cell beyond genome duplication. In this issue, Parks et al. (2009) find that the beta clamp interacts with the transposition protein TnsE to target the Tn7 transposon to discontinuously replicating DNA at the replication fork.
Chandler
Mick
M
Laboratoire de Microbiologie et Génétique Moléculaire UMR 5100, CNRS, 31062 Toulouse CEDEX, France. mike@ibcg.biotoul.fr
D004258:DNA Polymerase III / Q000378:metabolism; D004261:DNA Replication; D004251:DNA Transposable Elements; D004926:Escherichia coli / Q000235:genetics* / Q000378:metabolism
D004251:DNA Transposable Elements; C101139:beta subunit, DNA polymerase III; D004258:DNA Polymerase III