title: Synthesis and structure-activity relationships of allosteric potentiators of the m(4) muscarinic acetylcholine receptor.
authors.affiliation: Department of Chemistry, Vanderbilt University, 12475 MRB4, Nashville, TN 37232-6600 (USA).
authors.forename: J Phillip
authors.initials: JP
authors.lastname: Kennedy
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Bridges
authors.forename: Patrick R
authors.initials: PR
authors.lastname: Gentry
authors.forename: John T
authors.initials: JT
authors.lastname: Brogan
authors.forename: Alexander S
authors.initials: AS
authors.lastname: Kane
authors.forename: Carrie K
authors.initials: CK
authors.lastname: Jones
authors.forename: Ashley E
authors.initials: AE
authors.lastname: Brady
authors.forename: Jana K
authors.initials: JK
authors.lastname: Shirey
authors.forename: P Jeffrey
authors.initials: PJ
authors.lastname: Conn
authors.forename: Craig W
authors.initials: CW
authors.lastname: Lindsley
mesh_terms: D000494:Allosteric Regulation / Q000187:drug effects; D000818:Animals; D016466:CHO Cells; D006224:Cricetinae; D003412:Cricetulus; D018721:Muscarinic Agonists / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D043588:Receptor, Muscarinic M4 / Q000819:agonists*; D013329:Structure-Activity Relationship
chemical_list: D018721:Muscarinic Agonists; D043588:Receptor, Muscarinic M4
references.citation: Br J Pharmacol. 2008 Jul;154(6):1166-81
references.pmid: 18469850
references.citation: Neuron. 1988 Jul;1(5):403-10
references.pmid: 3272174
references.citation: J Neurosci. 2008 Oct 8;28(41):10422-33
references.pmid: 18842902
references.citation: Science. 1987 Jul 31;237(4814):527-32
references.pmid: 3037705
references.citation: ACS Chem Biol. 2008 Sep 19;3(9):530-41
references.pmid: 18652471
references.citation: Curr Pharm Des. 2005;11(26):3353-61
references.pmid: 16250841
references.citation: Br J Pharmacol. 2008 Jul;154(5):1104-15
references.pmid: 18454168
references.citation: Nat Rev Drug Discov. 2007 Sep;6(9):721-33
references.pmid: 17762886
references.citation: Pharmacol Ther. 1993 Jun;58(3):319-79
references.pmid: 7504306
references.citation: Drug Discov Today. 2005 Dec;10(23-24):1613-27
references.pmid: 16376822
references.citation: Nat Rev Drug Discov. 2009 Jan;8(1):41-54
references.pmid: 19116626
references.citation: J Med Chem. 2000 Nov 16;43(23):4333-53
references.pmid: 11087557
references.citation: J Pharmacol Exp Ther. 2008 Dec;327(3):941-53
references.pmid: 18772318
references.citation: Neurochem Res. 2003 Apr;28(3-4):437-42
references.pmid: 12675128
references.citation: Mol Pharmacol. 2002 Jun;61(6):1297-302
references.pmid: 12021390
references.citation: Pharmacol Ther. 2008 Feb;117(2):232-43
references.pmid: 18082893
references.citation: Nat Chem Biol. 2008 Jan;4(1):42-50
references.pmid: 18059262