Sheehan's syndrome with pancytopenia--complete recovery after hormone replacement (case series with review).
Reports of pancytopenia in patients with Sheehan's syndrome are rare, because the disorder is not commonly seen in western countries. A case series of pancytopenia in three patients of Sheehan's syndrome is presented. Three women aged 22, 30, and 34 years developed Sheehan's syndrome preceded by post partum hemorrhage. During investigations, they were found to have pancytopenia with hypocellular marrow. Treatment with thyroxine and glucocorticoids resulted in complete recovery after attaining euthyroid and eucortisolemic state. Review of literature revealed the rarity of the disorder, with only four cases reported so far. Multiple anterior pituitary hormone deficiencies in Sheehan's syndrome are responsible for pancytopenia; replacement of thyroid and cortisol hormones results in complete recovery.
Laway
Bashir Ahmad
BA
Department of Endocrinology, Sher-i-Kashmir Institute of Medical Sciences, Soura, Srinagar, Jammu and Kashmir, India.
Bhat
Javid Rasool
JR
Mir
Shahnaz Ahmad
SA
Khan
Raja Sultan Zaman
RS
Lone
Mohd Iqbal
MI
Zargar
Abdul Hamid
AH
D000328:Adult; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007018:Hypopituitarism / Q000150:complications* / Q000188:drug therapy; D010198:Pancytopenia / Q000188:drug therapy / Q000209:etiology*; D010907:Pituitary Hormones / Q000172:deficiency; D006473:Postpartum Hemorrhage; D011247:Pregnancy; D013974:Thyroxine / Q000627:therapeutic use; D016896:Treatment Outcome; D055815:Young Adult
D005938:Glucocorticoids; D010907:Pituitary Hormones; D013974:Thyroxine