ABC transporters as potential targets for modulation of drug resistance.
ATP binding cassette transporters are implicated in multidrug resistant phenotypes of tumor cells and may be cancer stem cell markers. Inhibitors of drug efflux pumps represent an emerging group of potentially useful agents for the improvement of antitumor therapy. Here we provide an overview of drug transporter functions and modulation.
Gatti
L
L
Department of Experimental Oncology and Laboratories, Fondazione IRCCS Istituto Nazionale Tumori, 20133 Milan, Italy.
Beretta
G L
GL
Cossa
G
G
Zunino
F
F
Perego
P
P
D018528:ATP-Binding Cassette Transporters / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D000818:Animals; D019008:Drug Resistance, Neoplasm / Q000187:drug effects*; D006801:Humans
D018528:ATP-Binding Cassette Transporters