Effect of selective vaccination on a decrease in the rate of hepatitis B virus-positive Japanese first-time blood donors.
The government of Japan started a selective vaccination programme to prevent mother-to-infant infection by hepatitis B virus (HBV) since January 1986. The effect of the programme on first-time blood donors has not been examined in detail. Data of first-time blood donors aged 16-25 years from 1996 to 2007 were extracted from the Japanese Red Cross (JRC) donors' database. Principal component analysis (PCA) was used to visualize the birth-year-dependent group of rate of HBV-positive donors. According to the birth of year, donors were divided into four groups by PCA. After the start of the programme, donors born in 1986-1989 comprised a single group. Before the start of the programme, three groups (1980, 1981-1984 and 1985) were identified. Although a significant time-dependent decrease in the rate of HBV-positive donors was observed before the start of the programme, a significant difference in the rate of HBV-positive donors was observed around the start of the programme by regression analysis for 16-19-year-old first-time blood donors. The selective vaccination programme has been effective to prevent the vertical transmission of HBV from the analysis of first-time blood donors. On the other hand, vaccination of blood donors should be considered to reduce the risk of post-transfusion HBV infection, because the horizontal transmission increases in HBV-positive blood donors.
Yoshikawa
A
A
Japanese Red Cross Saitama Blood Center, Hidaka-shi, Saitama-ken 350-1213, Japan. yoshikawa@saitama.bc.jrc.or.jp
Suzuki
K
K
Abe
A
A
Tanaka
T
T
Yamaguchi
K
K
Tanaka
T
T
Ishikawa
Y
Y
Minegishi
K
K
Gotanda
Y
Y
Yugi
H
H
Uchida
S
S
Satake
M
M
Mizoguchi
H
H
Tadokoro
K
K
D000293:Adolescent; D000328:Adult; D001782:Blood Donors; D005260:Female; D006509:Hepatitis B / Q000517:prevention & control* / Q000635:transmission; D006515:Hepatitis B virus; D006801:Humans; D007564:Japan; D008297:Male; D012011:Red Cross; D012189:Retrospective Studies; D014611:Vaccination