Protein kinase C-inhibiting properties of the losartan metabolite EXP3179 make the difference.
Wenzel
Philip
P
Schulz
Eberhard
E
Münzel
Thomas
T
D047228:Angiotensin II Type 1 Receptor Blockers / Q000378:metabolism* / Q000627:therapeutic use*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000378:metabolism*; D019808:Losartan / Q000031:analogs & derivatives* / Q000378:metabolism* / Q000627:therapeutic use*; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism; D019255:NADPH Oxidases / Q000378:metabolism; D010586:Phagocytes / Q000378:metabolism; D011493:Protein Kinase C / Q000037:antagonists & inhibitors*
D047228:Angiotensin II Type 1 Receptor Blockers; C073600:2-butyl-4-chloro-1-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-1H-imidazole-5-carboxaldehyde; D019255:NADPH Oxidases; D011493:Protein Kinase C; D020780:Matrix Metalloproteinase 9; D019808:Losartan