title: Stress-related modulation of inflammation in experimental models of bowel disease and post-infectious irritable bowel syndrome: role of corticotropin-releasing factor receptors.
abstract: The interaction between gut inflammatory processes and stress is gaining increasing recognition. Corticotropin-releasing factor (CRF)-receptor activation in the brain is well established as a key signaling pathway initiating the various components of the stress response including in the viscera. In addition, a local CRF signaling system has been recently established in the gut. This review summarize the present knowledge on mechanisms through which both brain and gut CRF receptors modulate intestinal inflammatory processes and its relevance towards increased inflammatory bowel disease (IBD) activity and post-infectious irritable bowel syndrome (IBS) susceptibility induced by stress.
authors.affiliation: David Geffen School of Medicine at UCLA, CURE: Digestive Diseases Research Center-Animal Core, VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA. ckiank@mednet.ucla.edu
authors.forename: Cornelia
authors.initials: C
authors.lastname: Kiank
authors.forename: Yvette
authors.initials: Y
authors.lastname: Taché
authors.forename: Muriel
authors.initials: M
authors.lastname: Larauche
mesh_terms: D000818:Animals; D006801:Humans; D007249:Inflammation / Q000473:pathology*; D015212:Inflammatory Bowel Diseases / Q000473:pathology*; D043183:Irritable Bowel Syndrome / Q000473:pathology*; D018019:Receptors, Corticotropin-Releasing Hormone / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D013315:Stress, Psychological / Q000473:pathology*
chemical_list: D018019:Receptors, Corticotropin-Releasing Hormone
references.citation: Peptides. 2000 Dec;21(12):1799-809
references.pmid: 11150640
references.citation: Gastroenterology. 2007 Mar;132(3):913-20
references.pmid: 17383420
references.citation: Annu Rev Physiol. 2009;71:219-39
references.pmid: 18928406
references.citation: J Neuroimmunol. 2001 Sep 3;119(1):37-50
references.pmid: 11525798
references.citation: Curr Allergy Asthma Rep. 2004 Jan;4(1):47-54
references.pmid: 14680622
references.citation: Endocrinology. 1990 Jun;126(6):2837-44
references.pmid: 2161737
references.citation: J Immunol. 2006 Feb 1;176(3):1869-77
references.pmid: 16424218
references.citation: Ann N Y Acad Sci. 2008 Nov;1144:56-60
references.pmid: 19076364
references.citation: FEBS Lett. 2005 Aug 15;579(20):4259-64
references.pmid: 16054139
references.citation: J Gastroenterol. 2007 Jan;42 Suppl 17:48-51
references.pmid: 17238026
references.citation: Mol Endocrinol. 2008 Nov;22(11):2505-19
references.pmid: 18772229
references.citation: Ann N Y Acad Sci. 2008 Dec;1148:29-41
references.pmid: 19120089
references.citation: Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):11008-13
references.pmid: 18669662
references.citation: Biochem Biophys Res Commun. 1994 Oct 28;204(2):828-34
references.pmid: 7980549
references.citation: Peptides. 2007 Jul;28(7):1453-60
references.pmid: 17586086
references.citation: Expert Opin Ther Targets. 2007 Nov;11(11):1401-13
references.pmid: 18028006
references.citation: Curr Mol Med. 2008 Jun;8(4):258-73
references.pmid: 18537634
references.citation: Curr Opin Immunol. 2007 Aug;19(4):435-40
references.pmid: 17629469
references.citation: Neurosci Lett. 1990 Dec 11;120(2):151-4
references.pmid: 2293102
references.citation: Ann N Y Acad Sci. 2009 Feb;1153:120-30
references.pmid: 19236335
references.citation: Inflamm Bowel Dis. 2007 Jul;13(7):918-32
references.pmid: 17343284
references.citation: J Neuroendocrinol. 2008 Jun;20(6):880-4
references.pmid: 18601712
references.citation: Inflamm Bowel Dis. 2007 Feb;13(2):175-81
references.pmid: 17206699
references.citation: J Comp Neurol. 2006 Jan 1;494(1):63-74
references.pmid: 16304680
references.citation: Am J Gastroenterol. 2009 May;104(5):1205-12
references.pmid: 19367268
references.citation: Gastroenterology. 2002 Aug;123(2):505-15
references.pmid: 12145804
references.citation: Curr Gastroenterol Rep. 2007 Oct;9(5):378-84
references.pmid: 17991338
references.citation: Pharmacol Rev. 2003 Mar;55(1):21-6
references.pmid: 12615952
references.citation: Gut. 2006 Nov;55(11):1640-9
references.pmid: 17047110
references.citation: J Nerv Ment Dis. 2009 Mar;197(3):154-60
references.pmid: 19282680
references.citation: Exp Dermatol. 2009 Mar;18(3):199-204
references.pmid: 18803662
references.citation: J Clin Invest. 2007 Jan;117(1):33-40
references.pmid: 17200704
references.citation: Mucosal Immunol. 2008 Jan;1(1):11-22
references.pmid: 19079156
references.citation: J Allergy Clin Immunol. 2009 Jul;124(1):3-20; quiz 21-2
references.pmid: 19560575
references.citation: J Pediatr. 2009 Sep;155(3):416-20
references.pmid: 19535093
references.citation: Curr Gastroenterol Rep. 2009 Aug;11(4):270-7
references.pmid: 19615302
references.citation: J Clin Gastroenterol. 2004 Sep;38(8):658-63
references.pmid: 15319647
references.citation: Endocrinology. 2008 Jul;149(7):3403-9
references.pmid: 18403481
references.citation: Ann N Y Acad Sci. 2008 Nov;1143:83-104
references.pmid: 19076346
references.citation: Dig Dis Sci. 2002 Aug;47(8):1716-22
references.pmid: 12184520
references.citation: J Physiol. 2007 Apr 1;580(Pt 1):347-56
references.pmid: 17234701
references.citation: J Biol Chem. 2008 Nov 21;283(47):32900-12
references.pmid: 18801728
references.citation: Neurogastroenterol Motil. 2009 Apr;21(4):389-98
references.pmid: 19126184
references.citation: Gut. 2007 Jun;56(6):802-8
references.pmid: 17148502
references.citation: Annu Rev Psychol. 2009;60:501-24
references.pmid: 19035829
references.citation: J Physiol. 2004 May 15;557(Pt 1):191-205
references.pmid: 15020692
references.citation: Curr Mol Med. 2008 Jun;8(4):247-52
references.pmid: 18537632
references.citation: World J Gastroenterol. 2007 Jun 14;13(22):3027-30
references.pmid: 17589915
references.citation: J Clin Invest. 2007 Feb;117(2):289-96
references.pmid: 17273548
references.citation: Curr Gastroenterol Rep. 2008 Aug;10(4):385-90
references.pmid: 18627650
references.citation: Annu Rev Immunol. 2007;25:193-219
references.pmid: 17129180
references.citation: Cell. 2006 Feb 24;124(4):783-801
references.pmid: 16497588
references.citation: J Neuropsychiatry Clin Neurosci. 1998 Spring;10(2):230-1
references.pmid: 9722327
references.citation: Neurogastroenterol Motil. 2008 Oct;20(10):1147-56
references.pmid: 18761632
references.citation: J Clin Endocrinol Metab. 2004 Nov;89(11):5352-61
references.pmid: 15531481
references.citation: Curr Gastroenterol Rep. 2007 Dec;9(6):508-12
references.pmid: 18377804
references.citation: Endocr Rev. 2006 May;27(3):260-86
references.pmid: 16484629
references.citation: J Mol Endocrinol. 2000 Aug;25(1):43-52
references.pmid: 10915217
references.citation: Gut. 2008 Jan;57(1):50-8
references.pmid: 17525093
references.citation: J Immunol. 2007 Apr 15;178(8):4937-46
references.pmid: 17404275
references.citation: Science. 1991 Oct 18;254(5030):421-3
references.pmid: 1925600
references.citation: Science. 2004 Mar 12;303(5664):1624-5
references.pmid: 15016988
references.citation: Gut. 2008 Apr;57(4):468-73
references.pmid: 18194987
references.citation: Trends Pharmacol Sci. 2004 Nov;25(11):563-8
references.pmid: 15491778
references.citation: Life Sci. 1994;54(8):539-43
references.pmid: 8107531
references.citation: Gut. 2007 Sep;56(9):1210-7
references.pmid: 17412781
references.citation: Life Sci. 2009 Jun 5;84(23-24):847-52
references.pmid: 19345697
references.citation: J Immunol. 2006 Sep 1;177(5):3355-61
references.pmid: 16920976
references.citation: Drug Discov Today. 2009 Jul;14(13-14):713-20
references.pmid: 19379831
references.citation: Front Neuroendocrinol. 2007 Apr;28(1):1-27
references.pmid: 17083971
references.citation: Gut. 2005 Oct;54(10):1396-401
references.pmid: 15923667
references.citation: Neurogastroenterol Motil. 2005 Feb;17(1):4-15
references.pmid: 15670258
references.citation: J Cell Physiol. 2007 Mar;210(3):774-83
references.pmid: 17117478
references.citation: Pain. 2006 Jul;123(1-2):179-86
references.pmid: 16630696
references.citation: J Neurochem. 2004 Jul;90(2):309-16
references.pmid: 15228587
references.citation: Brain Behav Immun. 2002 Dec;16(6):622-53
references.pmid: 12480495
references.citation: Am J Physiol Gastrointest Liver Physiol. 2002 Dec;283(6):G1388-97
references.pmid: 12388206
references.citation: J Mol Endocrinol. 2009 May;42(5):397-405
references.pmid: 19211730
references.citation: Neurogastroenterol Motil. 2009 Jun;21(6):644-50, e27
references.pmid: 19222763
references.citation: Infect Immun. 2002 Nov;70(11):6068-74
references.pmid: 12379683
references.citation: Nat Rev Immunol. 2007 Jan;7(1):52-63
references.pmid: 17186031
references.citation: Cell Immunol. 2008 Mar-Apr;252(1-2):16-26
references.pmid: 18279846
references.citation: Gut. 1995 Oct;37(4):544-51
references.pmid: 7489943
references.citation: World J Gastroenterol. 2008 Jan 21;14(3):390-400
references.pmid: 18200661
references.citation: Gastroenterology. 2009 May;136(6):1979-88
references.pmid: 19457422
references.citation: Front Biosci (Landmark Ed). 2009 Jan 01;14(7):2765-78
references.pmid: 19273235
references.citation: Cell Physiol Biochem. 2009;23(1-3):87-96
references.pmid: 19255503
references.citation: Gut. 2009 Oct;58(10):1333-41
references.pmid: 19324867
references.citation: Mol Pharmacol. 2009 Mar;75(3):648-57
references.pmid: 19098121
references.citation: Curr Med Chem. 2005;12(13):1503-12
references.pmid: 15974983