When mutants gain new powers: news from the mutant p53 field.
Ample data indicate that mutant p53 proteins not only lose their tumour suppressive functions, but also gain new abilities that promote tumorigenesis. Moreover, recent studies have modified our view of mutant p53 proteins, portraying them not as inert mutants, but rather as regulated proteins that influence the cancer cell transcriptome and phenotype. This influence is clinically manifested as association of TP53 mutations with poor prognosis and drug resistance in a growing array of malignancies. Here, we review recent studies on mutant p53 regulation, gain-of-function mechanisms, transcriptional effects and prognostic association, with a focus on the clinical implications of these findings.
Brosh
Ran
R
Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel.
Rotter
Varda
V
D000818:Animals; D004195:Disease Models, Animal; D016158:Genes, p53 / Q000235:genetics*; D006801:Humans; D051379:Mice; D009154:Mutation; D009369:Neoplasms / Q000378:metabolism*; D011379:Prognosis; D014158:Transcription, Genetic / Q000235:genetics*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
D016159:Tumor Suppressor Protein p53
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