Signalling crosstalk in B cells: managing worth and need.
The B cell receptor (BCR) and the receptor for B cell-activating factor (BAFFR) have complementary roles in B cells: BCR signals provide a cell-intrinsic measure of suitability for negative or positive selection, whereas BAFFR responds to homeostatic demands based on a cell-extrinsic measure of the size of the mature B cell pool. Because continuous signals from both receptors are required for B cell survival, it is probable that there are mechanisms to integrate the selective and homeostatic signals from these receptors. In this Opinion article, I describe recent evidence to indicate that crosstalk between the downstream biochemical pathways of these receptors mediates this interdependence, such that BCR signals generate a limiting substrate for BAFFR signal propagation.
Cancro
Michael P
MP
284 John Morgan Building, University of Pennsylvania School of Medicine, 36th and Hamilton Walk, Philadelphia, Pennsylvania 19104, USA. cancro@mail.med.upenn.edu
D000818:Animals; D053264:B-Cell Activating Factor / Q000276:immunology* / Q000378:metabolism; D053265:B-Cell Activation Factor Receptor / Q000276:immunology* / Q000378:metabolism; D001402:B-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D002450:Cell Communication / Q000276:immunology*; D002454:Cell Differentiation / Q000276:immunology; D006801:Humans; D011947:Receptors, Antigen, B-Cell / Q000276:immunology* / Q000378:metabolism; D015398:Signal Transduction / Q000276:immunology
D053264:B-Cell Activating Factor; D053265:B-Cell Activation Factor Receptor; D011947:Receptors, Antigen, B-Cell
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