title: [Neuroendocrine carcinoma with large cells of the breast: case report and review of the literature].
abstract: Neuroendocrine carcinoma with large cells is a slightly different tumor from the high rank of malignity. We report a case of breast localization in a 28-year-old patient. It is a locally advanced classified T4dN1M0 tumor that required neoadjuvant chemotherapy. The clinical answer was 75% of the level of the tumor. A standard surgery mastectomy with axillary lymph node dissection was realized, followed by external radiotherapy. The anatomopathologic and the immuno-histochemical study of the operational part confirmed the diagnosis of neuroendocrine carcinoma with large cells expressing the progesterone receptor. The patient is subjected to adjuvant hormonal treatment. After a 12 months retreat, a complete remission is maintained. Considering the scarcity of neuroendocrine carcinoma with large cells of the breast, the therapeutic standard is not yet available and the forecast remains difficult to determine.
authors.affiliation: Centre d'oncologie, CHU Ibn Rochd-Casablanca, Morocco. zouhourbourhaleb240@hotmail.com
authors.forename: Z
authors.initials: Z
authors.lastname: Bourhaleb
authors.forename: N
authors.initials: N
authors.lastname: Uri
authors.forename: H
authors.initials: H
authors.lastname: Haddad
authors.forename: S
authors.initials: S
authors.lastname: Azzouzi
authors.forename: S
authors.initials: S
authors.lastname: Zamiati
authors.forename: N
authors.initials: N
authors.lastname: Benchakroun
authors.forename: N
authors.initials: N
authors.lastname: Tawfiq
authors.forename: H
authors.initials: H
authors.lastname: Jouhadi
authors.forename: S
authors.initials: S
authors.lastname: Sahraoui
authors.forename: A
authors.initials: A
authors.lastname: Benider
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000473:pathology* / Q000628:therapy; D018278:Carcinoma, Neuroendocrine / Q000473:pathology* / Q000628:therapy; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D008408:Mastectomy; D020360:Neoadjuvant Therapy