Increased concentrations of serotonin and 5-hydroxyindoleacetic acid in blood plasma from patients with pulmonary hypertension due to mitral valve disease.
Serotonin content in the plasma and platelets and 5-hydroxyindoleacetic acid concentration in the plasma were shown to increase in patients with pulmonary arterial hypertension due to mitral valve disease. A positive correlation was found between the severity of pulmonary arterial hypertension and concentrations of serotonin (r=0.48) and 5-hydroxyindoleacetic acid in the plasma (r=0.9).
Kirillova
V V
VV
Department of Normal Physiology, Kazan State Medical University, Kazan, Tatarstan.
Nigmatullina
R R
RR
Dzhordzhikiya
R K
RK
Kudrin
V S
VS
Klodt
P M
PM
D000328:Adult; D000368:Aged; D001794:Blood Pressure; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006349:Heart Valve Diseases / Q000097:blood* / Q000150:complications; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000097:blood*; D006976:Hypertension, Pulmonary / Q000097:blood* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve; D012701:Serotonin / Q000097:blood*; D012720:Severity of Illness Index
D012701:Serotonin; D006897:Hydroxyindoleacetic Acid