Molecular neurodevelopment: an in vivo 31P-1H MRSI study.
Synaptic development and elimination are normal neurodevelopmental processes, which if altered could contribute to various neuropsychiatric disorders. 31P-1H magnetic resonance spectroscopic imaging (MRSI) and structural magnetic resonance imaging (MRI) exams were conducted on 105 healthy children ages 6-18 years old to identify neuromolecular indices of synaptic development and elimination. Over the age range studied, age-related changes in high-energy phosphate (phosphocreatine), membrane phospholipid metabolism (precursors and breakdown products), and percent gray matter volume were found. These neuromolecular and structural indices of synaptic development and elimination are associated with development of several cognitive domains. Monitoring of these molecular markers is essential for devising treatment strategies for neurodevelopmental disorders.
Goldstein
Gerald
G
VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, USA.
Panchalingam
Kanagasabai
K
McClure
Richard J
RJ
Stanley
Jeffrey A
JA
Calhoun
Vince D
VD
Pearlson
Godfrey D
GD
Pettegrew
Jay W
JW
D000293:Adolescent; D000367:Age Factors; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D001921:Brain / Q000000981:diagnostic imaging* / Q000254:growth & development / Q000502:physiology*; D001931:Brain Mapping; D002648:Child; D003071:Cognition / Q000502:physiology*; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009483:Neuropsychological Tests; D010725:Phosphocreatine / Q000378:metabolism; D010761:Phosphorus Radioisotopes / Q000378:metabolism; D011522:Protons; D011877:Radionuclide Imaging; D013057:Spectrum Analysis; D013223:Statistics as Topic
D010761:Phosphorus Radioisotopes; D011522:Protons; D010725:Phosphocreatine; D001224:Aspartic Acid; C000179:N-acetylaspartate
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