Amphiphilic polymer nanoparticles: characterization and assessment as new drug carriers.
An amino-acid-based hydrophobically modified biocompatible copolymer, poly[(sodium N-acryloyl-L-valinate)-co-(N-octylacrylamide)] was synthesized and characterized. Techniques such as fluorescence probes, DLS, and TEM were used to investigate its aggregation behavior in aqueous solution. The copolymer was observed to form micellar aggregates having diameters in the nanometer range in aqueous solution (pH = 8) through inter-chain hydrophobic association. This behavior was found to be similar to that of poly[(sodium N-acryloyl-L-valinate)-co-(N-dodecylacrylamide)]. The compact micellar nanostructures were observed to be stable with respect to changes of pH and temperature. The encapsulation and release of griseofulvin, a hydrophobic model drug, was studied.
Dutta
Pranabesh
P
Department of Chemistry, Indian Institute of Technology, Kharagpur 721302, India.
Shrivastava
Saurabh
S
Dey
Joykrishna
J
D001672:Biocompatible Materials / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D006118:Griseofulvin / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008422:Materials Testing; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D013696:Temperature
D001672:Biocompatible Materials; D004337:Drug Carriers; D011108:Polymers; D006118:Griseofulvin