Plasma levels of inflammatory and thrombotic/fibrinolytic markers in acute ischemic strokes: relationship with TOAST subtype, outcome and infarct site.
BACKGROUND
The aim of our study was to evaluate in patients with acute ischemic stroke the relationship between immuno-inflammatory variables, clinical outcome and infarct site.


METHODS
We evaluated plasma levels of IL-1beta, TNF-alpha, IL-6 and IL-10, E-selectin, P-selectin, sICAM-1 ,sVCAM-1 vWF, TPA and PAI-1.


RESULTS
Patients with cardioembolic subtype showed significantly higher median plasma levels of TNF-alpha, IL-6, IL-1beta whereas the lacunar subtype showed significantly lower median plasma levels of TNF-alpha, IL-6 and IL-1beta.


CONCLUSIONS
A significant association was noted between the severity of neurological deficit at admission, the diagnostic subtype and some inflammatory variables.
Tuttolomondo
Antonino
A
Dipartimento Biomedico di Medicina Interna e Specialistica, Università degli Studi di Palermo, P.zza delle Cliniche, Palermo, Italy. brunotutto@unipa.it
Di Sciacca
Riccardo
R
Di Raimondo
Domenico
D
Serio
Antonia
A
D'Aguanno
Gisella
G
La Placa
Sergio
S
Pecoraro
Rosaria
R
Arnao
Valentina
V
Marino
Luciana
L
Monaco
Serena
S
Natalè
Eraldo
E
Licata
Giuseppe
G
Pinto
Antonio
A
D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D002545:Brain Ischemia / Q000097:blood* / Q000145:classification* / Q000473:pathology; D002544:Cerebral Infarction / Q000097:blood / Q000145:classification / Q000473:pathology; D005260:Female; D005342:Fibrinolysis / Q000502:physiology*; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D020767:Intracranial Thrombosis / Q000097:blood / Q000145:classification / Q000473:pathology; D008297:Male; D008875:Middle Aged; D020521:Stroke / Q000097:blood* / Q000145:classification* / Q000473:pathology
D015415:Biomarkers; D018836:Inflammation Mediators