[Biology and immunotherapy advance of interleukin 2 and interleukin 15-review].
IL-2 and IL-15 play an important roles in regulating the lymphocyte function and homeostasis. Advances in understanding of the cellular and molecular biology of IL-2 and IL-15 and their receptor complex have provided rationale to better utilize them to expand and activate immune effectors in patients with cancer. These two cytokines stimulate similar responses from lymphocytes in vitro, but play markedly distinct roles in lymphoid biology in vivo. Their distinct physiological functions can be ascribed to distinct signaling pathways initiated by distinct cytokine receptor subunits, differential expression patterns of their receptors. Recently, the discovery of a novel mechanism of IL-15 cytokine signaling, trans-presentation, has provided insights into the divergent ways of these cytokine function. Although their heterotrimeric receptors have two receptor subunits in common, these two cytokines have contrasting roles in adaptive immune responses. The unique role of interleukin 2 is in the elimination of self-reactive T cells to prevent autoimmunity. By contrast, interleukin 15 is dedicated to the prolonged maintenance of memory T-cell responses to pathogens. As discussed in this article, the biology of IL-2 and IL-15 two cytokines will affect the development of novel treatment for malignancies and autoimmune diseases.
Chen
Guang-Hua
GH
Key laboratory of Thrombosis and Hemostasis, The First Affiliated Hospital, Suzhou University, Jiangsu Institute of Hematology, Suzhou 215006, Jiangsu Province, China.
Wu
De-Pei
DP
D006801:Humans; D007167:Immunotherapy; D019409:Interleukin-15 / Q000276:immunology* / Q000378:metabolism*; D007376:Interleukin-2 / Q000276:immunology* / Q000378:metabolism*
D019409:Interleukin-15; D007376:Interleukin-2