Biological determinants of endocrine resistance in breast cancer.
Endocrine therapies targeting oestrogen action (anti-oestrogens, such as tamoxifen, and aromatase inhibitors) decrease mortality from breast cancer, but their efficacy is limited by intrinsic and acquired therapeutic resistance. Candidate molecular biomarkers and gene expression signatures of tamoxifen response emphasize the importance of deregulation of proliferation and survival signalling in endocrine resistance. However, definition of the specific genetic lesions and molecular processes that determine clinical endocrine resistance is incomplete. The development of large-scale computational and genetic approaches offers the promise of identifying the mediators of endocrine resistance that may be exploited as potential therapeutic targets and biomarkers of response in the clinic.
Musgrove
Elizabeth A
EA
Cancer Research Program, Garvan Institute of Medical Research, Sydney, New South Wales 2010, Australia. e.musgrove@garvan.org.au
Sutherland
Robert L
RL
D001943:Breast Neoplasms / Q000188:drug therapy*; D019008:Drug Resistance, Neoplasm; D005260:Female; D006727:Hormone Antagonists / Q000627:therapeutic use*; D006801:Humans; D009376:Neoplasms, Hormone-Dependent / Q000188:drug therapy*; D015398:Signal Transduction / Q000187:drug effects
D006727:Hormone Antagonists
Proc Natl Acad Sci U S A. 2004 Feb 10;101(6):1566-71
14745018
Endocr Relat Cancer. 2003 Jun;10(2):179-86
12790780
Vitam Horm. 2005;71:201-37
16112269
Cancer Res. 2002 Dec 1;62(23):6916-23
12460907
FASEB J. 2007 Dec;21(14):4013-27
17660348
Best Pract Res Clin Endocrinol Metab. 2008 Aug;22(4):615-23
18971122
J Clin Oncol. 1999 May;17(5):1474-81
10334533
Clin Cancer Res. 2005 Jul 15;11(14):5319-28
16033851
Clin Cancer Res. 1995 Feb;1(2):189-98
9815973
Nat Rev Cancer. 2002 Feb;2(2):101-12
12635173
Mol Cancer Res. 2009 Mar;7(3):402-14
19276186
PLoS One. 2008 Aug 20;3(8):e2987
18714337
Endocr Rev. 2008 Apr;29(2):217-33
18216219
N Engl J Med. 2004 Dec 30;351(27):2817-26
15591335
Int J Oncol. 2006 May;28(5):1031-42
16596219
Cancer Res. 2008 Jul 15;68(14):5628-38
18632615
Nat Rev Cancer. 2007 Jan;7(1):46-53
17186017
J Biol Chem. 2008 Oct 31;283(44):29897-903
18708351
Cancer Res. 2008 Feb 1;68(3):852-60
18245487
J Natl Cancer Inst. 2006 Feb 15;98(4):262-72
16478745
N Engl J Med. 2006 Aug 10;355(6):560-9
16899776
Ann Oncol. 2004 Jun;15(6):885-90
15151944
Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10393-8
12917485
Breast Cancer Res Treat. 2007 Apr;102(2):173-9
17004114
Clin Cancer Res. 2004 Dec 1;10(23):8059-67
15585641
Cancer Lett. 2007 Oct 18;256(1):1-24
17475399
Nature. 2008 Oct 2;455(7213):679-83
18716624
Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8418-23
12829800
Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):9042-6
10908655
J Clin Oncol. 2007 Dec 20;25(36):5815-24
17893378
Clin Cancer Res. 2004 Nov 15;10(22):7764-74
15570011
Breast Cancer. 2006;13(2):137-44
16755107
Clin Cancer Res. 2006 Feb 1;12(3 Pt 2):1024s-1030s
16467120
Ann Oncol. 2003 Jul;14(7):1051-6
12853346
Mol Endocrinol. 1993 Jul;7(7):870-8
8413311
Cancer Res. 2003 Oct 15;63(20):6802-8
14583477
Breast Cancer Res. 2004;6(5):213-8
15318928
Mol Cancer Ther. 2005 Jan;4(1):33-41
15657351
Cancer Cell. 2004 Mar;5(3):207-13
15050912
J Biol Chem. 2005 May 6;280(18):17617-25
15757889
Bioinformatics. 2005 Jan 15;21(2):171-8
15308542
Clin Cancer Res. 2004 Sep 1;10(17):5902-6
15355923
Endocr Rev. 1999 Jun;20(3):358-417
10368776
Int J Cancer. 1997 Aug 7;72(4):700-5
9259413
Endocrinology. 2001 Jul;142(7):2776-88
11415996
Endocr Relat Cancer. 2006 Jun;13(2):327-34
16728566
Clin Cancer Res. 2006 Jun 1;12(11 Pt 1):3288-96
16740749
Clin Cancer Res. 2006 Apr 15;12(8):2468-75
16638854
J Natl Cancer Inst. 2008 Oct 1;100(19):1380-8
18812550
BMC Genomics. 2008 May 22;9:239
18498629
Eur J Cancer. 2006 May;42(8):1104-12
16603346
Lancet. 2005 May 14-20;365(9472):1687-717
15894097
Clin Cancer Res. 2004 Sep 15;10(18 Pt 1):6194-202
15448007
J Biol Chem. 2008 Nov 7;283(45):31079-86
18790736
Cell. 2007 Jun 29;129(7):1275-86
17570480
J Clin Oncol. 2005 Mar 10;23(8):1636-43
15755971
J Clin Oncol. 2005 Feb 1;23(4):732-40
15681518
Int J Oncol. 2006 Jan;28(1):67-76
16327981
N Engl J Med. 1983 Dec 1;309(22):1343-7
6633596
Breast Cancer Res Treat. 2009 May;115(1):77-85
18521745
J Clin Invest. 2007 Jan;117(1):218-28
17160137
Cancer Res. 2008 Nov 1;68(21):8796-804
18974122
Nat Rev Mol Cell Biol. 2005 Jul;6(7):542-54
15957004
Breast Cancer Res Treat. 2009 Mar;114(1):23-30
18351453
J Cell Biochem. 2006 Feb 1;97(2):261-74
16267837
Breast Cancer Res Treat. 2009 Jan;113(2):275-83
18311582
PLoS One. 2007 Dec 05;2(12):e1256
18060053
Int J Cancer. 2008 Jul 1;123(1):85-8
18386815
J Clin Oncol. 2008 Sep 1;26(25):4078-85
18757322
Mol Cell Biol. 1998 Aug;18(8):4499-508
9671459
J Biol Chem. 2003 Jul 25;278(30):28264-73
12740391
Clin Cancer Res. 2008 Mar 15;14(6):1744-52
18347175
J Natl Cancer Inst. 2003 Mar 5;95(5):353-61
12618500
Clin Cancer Res. 1999 Feb;5(2):251-6
10037172
Pharmacol Rev. 1998 Jun;50(2):151-96
9647865
J Natl Cancer Inst. 2007 Jan 17;99(2):167-70
17228000
J Pathol. 2005 Oct;207(2):139-46
16088978
BMC Cancer. 2007 Apr 03;7:59
17407600
BMC Cancer. 2007 Sep 25;7:182
17894856
J Clin Oncol. 2009 Feb 1;27(4):542-9
19075277
Lancet. 2005 Feb 19-25;365(9460):671-9
15721472
Clin Cancer Res. 2003 Aug 1;9(8):2933-9
12912939
J Clin Oncol. 2008 Aug 1;26(22):3727-34
18669459
Mol Cancer Res. 2006 Jun;4(6):379-86
16778085
Breast Cancer Res. 2008;10(4):R65
18662380
Mol Cancer Ther. 2002 Jul;1(9):707-17
12479367
Mod Pathol. 2005 Feb;18(2):250-9
15475931
J Clin Oncol. 2009 Jul 20;27(21):3423-9
19487384
Neoplasia. 2008 Jan;10(1):79-88
18231641
Endocr Relat Cancer. 2005 Jul;12 Suppl 1:S47-59
16113099
Breast Cancer Res Treat. 2008 Dec;112(3):475-88
18327671
Cancer Res. 2008 Nov 1;68(21):8908-17
18974135
Gene. 2002 Oct 16;299(1-2):35-55
12459251
Br J Cancer. 2000 Dec;83(12):1688-95
11104567
Mol Cell. 2008 Jul 25;31(2):212-21
18657504
Clin Cancer Res. 2009 Mar 15;15(6):2098-106
19276281
Lancet. 1985 Feb 16;1(8425):364-6
2857419
Nat Rev Cancer. 2003 Nov;3(11):821-31
14668813
Oncogene. 2009 Apr 16;28(15):1812-20
19287456
J Natl Cancer Inst. 2000 Jan 19;92(2):112-20
10639512
Cancer Res. 2003 Aug 1;63(15):4322-6
12907598
J Clin Oncol. 2006 Apr 10;24(11):1656-64
16505416
Neoplasia. 2007 May;9(5):443-54
17534450
Clin Cancer Res. 2003 Jun;9(6):1980-9
12796359
J Clin Oncol. 2003 Oct 1;21(19):3594-600
14512390
Oncogene. 2002 Jul 11;21(30):4626-34
12096339
Breast Cancer Res Treat. 2003 Sep;81(1):81-93
14531500
Cancer Res. 2009 Mar 15;69(6):2252-9
19276356
Breast Cancer Res. 2007;9(5):112
17980056
Endocr Rev. 2004 Dec;25(6):869-98
15583021
J Natl Cancer Inst. 1998 Jun 3;90(11):814-23
9625169
Science. 2002 May 31;296(5573):1642-4
12040178
Breast Cancer Res Treat. 2009 Jan;113(2):253-60
18299979
J Clin Oncol. 2007 Apr 1;25(10):1239-46
17401012
Breast Cancer Res. 2008;10(5):R88
18928543
Clin Cancer Res. 2004 Sep 1;10(17):5670-6
15355892
Cancer Chemother Pharmacol. 2007 Sep;60(4):535-43
17186241
J Biol Chem. 2000 Dec 8;275(49):38221-9
10991938
Endocr Relat Cancer. 2008 Mar;15(1):101-11
18310279
Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10869-74
11553815
Nat Rev Cancer. 2006 Sep;6(9):735-41
16915294
Mol Cell Biol. 2009 Sep;29(17):4623-39
19564413
J Clin Oncol. 2006 Apr 10;24(11):1770-83
16603719
Nature. 2008 Dec 4;456(7222):663-6
19005469
Endocrinology. 2003 Mar;144(3):1032-44
12586780
Clin Cancer Res. 2008 Sep 1;14(17):5555-64
18765548
Cancer Res. 2009 May 15;69(10):4192-201
19435893
JAMA. 2008 Apr 2;299(13):1574-87
18387932
Cancer Res. 1989 Jan 1;49(1):112-6
2642286
Breast Cancer Res Treat. 2010 Apr;120(2):401-8
19412734
J Clin Oncol. 2005 Apr 10;23(11):2469-76
15753463
Apoptosis. 2001 Dec;6(6):469-77
11595837
Autophagy. 2009 Apr;5(3):400-3
19221464
J Natl Cancer Inst. 2000 Jan 19;92(2):120-7
10639513
Cancer Res. 2000 Oct 15;60(20):5887-94
11059787
Cancer Cell. 2004 Jun;5(6):607-16
15193263
Cancer Cell. 2006 Dec;10(6):529-41
17157792
Breast Cancer Res Treat. 2008 Aug;110(3):427-37
17902051
Endocr Relat Cancer. 2005 Jul;12 Suppl 1:S37-46
16113098
Clin Cancer Res. 2006 Feb 1;12(3 Pt 2):1001s-1007s
16467116
Nat Rev Cancer. 2009 Aug;9(8):576-86
19629072
EMBO J. 1998 May 15;17(10):2799-808
9582273
Biochem J. 2009 Jan 1;417(1):361-70
18976239
Int J Cancer. 2002 May 1;99(1):35-42
11948489
Cancer Res. 2006 Jun 15;66(12):5985-8
16778166
N Engl J Med. 2009 Feb 19;360(8):790-800
19228622
Endocr Relat Cancer. 2004 Dec;11(4):643-58
15613444
Oncogene. 2003 Oct 20;22(47):7316-39
14576841
Breast Cancer Res Treat. 2008 Dec;112(3):489-501
18338247
J Natl Cancer Inst. 2000 Dec 6;92(23):1926-34
11106684
Breast Cancer Res. 2007;9(5):306
17980055
J Cell Biochem. 2009 May 15;107(2):364-75
19330798
Rev Endocr Metab Disord. 2007 Sep;8(3):241-53
17486454
Cancer Res. 2002 Jun 15;62(12):3428-37
12067985
Oncogene. 2003 Jul 31;22(31):4898-904
12894232
Trans Am Clin Climatol Assoc. 2008;119:77-90; discussion 90-2
18596862
Nat Rev Cancer. 2008 Apr;8(4):253-67
18354415