Ustekinumab in the therapy of chronic plaque psoriasis.
Psoriasis is a chronic inflammatory disorder characterized by T cell dysregulation and a chronic inflammatory infiltrate within the epidermis. Several cytokines play an important role in the pathogenesis of psoriasis, including interleukin-12 (IL-12) and IL-23. These cytokines act via induction of pro-inflammatory cytokines which promote chronic inflammation and auto-reactivity. Ustekinumab is a fully human monoclonal antibody against the common p40 subunit of IL-12 and IL-23. Two randomized, double-blind, placebo-controlled trials of ustekinumab have demonstrated significant and prolonged efficacy in the treatment of plaque psoriasis. Adverse events were generally similar across treatment and control groups. Studies are ongoing to assess the long term safety and efficacy profiles of ustekinumab.
O'Neill
Jenna L
JL
State University of New York, at Buffalo, School of Medicine and Biomedical Sciences, Department of Dermatology, NY, USA.
Kalb
Robert E
RE
N Engl J Med. 2007 Feb 8;356(6):580-92
17287478
J Immunol. 1999 Apr 1;162(7):4069-78
10201930
Arch Dermatol Res (1975). 1977 Mar 25;258(1):9-16
857738
J Invest Dermatol. 1999 Nov;113(5):752-9
10571730
J Am Acad Dermatol. 2007 Dec;57(6):1059-68
17706835
J Exp Med. 1995 Jan 1;181(1):381-6
7528773
Curr Med Res Opin. 2007 May;23(5):1081-92
17519075
Br J Dermatol. 2008 May;158(5):1107-16
18373710
Lancet Neurol. 2008 Sep;7(9):796-804
18703004
Nat Immunol. 2002 Jun;3(6):549-57
12006974
Nat Immunol. 2007 Sep;8(9):950-7
17676044
J Exp Med. 2006 Nov 27;203(12):2577-87
17074928
Nat Immunol. 2005 Nov;6(11):1133-41
16200068
Clin Exp Immunol. 1998 Feb;111(2):377-83
9486407
Arch Dermatol. 1974 Feb;109(2):207-11
4814926
Arch Dermatol. 1999 Sep;135(9):1104-10
10490116
N Engl J Med. 2003 Nov 20;349(21):2004-13
14627785
Int J Biochem Cell Biol. 2009 Apr;41(4):733-5
18725317
J Exp Med. 2004 Mar 1;199(5):731-6
14981113
Immunity. 2000 Nov;13(5):715-25
11114383
JAMA. 2008 Oct 22;300(16):1887-96
18940975
Arch Dermatol. 2003 Jun;139(6):719-27
12810502
J Immunol. 2006 Oct 1;177(7):4917-26
16982934
Cochrane Database Syst Rev. 2000;(2):CD001976
10796842
J Invest Dermatol. 2004 Dec;123(6):1037-44
15610511
Immunity. 1996 May;4(5):471-81
8630732
J Invest Dermatol. 1998 Oct;111(4):645-9
9764847
J Immunol. 1991 Aug 1;147(3):874-82
1713608
Lancet. 2008 May 17;371(9625):1675-84
18486740
Eur J Immunol. 2002 Jan;32(1):261-9
11782017
J Immunol. 2004 Mar 1;172(5):2827-33
14978083
J Biol Chem. 2003 Jan 17;278(3):1910-4
12417590
Immunol Rev. 2004 Dec;202:96-105
15546388
J Immunol. 2006 May 1;176(9):5213-22
16621986
Eur J Immunol. 1996 Jul;26(7):1621-7
8766570
Science. 1998 May 29;280(5368):1435-8
9603733
Cytokine. 1999 Nov;11(11):822-30
10547269
J Invest Dermatol. 1998 Dec;111(6):1053-7
9856816
Lancet. 2008 May 17;371(9625):1665-74
18486739
N Engl J Med. 2005 May 5;352(18):1899-912
15872205
Eur J Immunol. 2006 May;36(5):1309-23
16619290
J Clin Invest. 1999 Dec;104(11):1527-37
10587516
Adv Immunol. 2001;79:55-92
11680011
Arch Dermatol. 2007 Jun;143(6):719-26
17576937
J Immunol. 2004 Aug 1;173(3):1887-93
15265921
Trends Immunol. 2006 Jan;27(1):17-23
16290228
J Exp Med. 1996 Aug 1;184(2):747-52
8760829
J Exp Med. 1996 Jan 1;183(1):147-57
8551218
J Dermatolog Treat. 2008;19(5):259-66
18629676
J Am Acad Dermatol. 2006 Nov;55(5):829-35
17052489
J Immunol. 1997 Aug 15;159(4):1658-65
9257825
J Exp Med. 2006 Oct 2;203(10):2271-9
16982811
J Clin Invest. 2002 Aug;110(4):493-7
12189243
Crit Rev Immunol. 2004;24(2):111-28
15581393
J Immunol. 2002 Jun 1;168(11):5699-708
12023369
Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):14002-7
8943050
Cytokine Growth Factor Rev. 2003 Oct;14(5):361-8
12948519
J Immunol. 1999 Jun 15;162(12):7480-91
10358203
Arch Dermatol Res. 1983;275(3):181-9
6604503
Expert Opin Ther Targets. 2005 Dec;9(6):1123-36
16300465
J Immunol. 2002 Jun 1;168(11):5448-54
12023338
Eur J Immunol. 1993 Aug;23(8):1762-70
8102100
Annu Rev Immunol. 1989;7:145-73
2523712
N Engl J Med. 2003 Nov 20;349(21):2014-22
14627786
Immunity. 1998 Sep;9(3):315-23
9768751
Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):15137-42
11752460
Nature. 2007 Feb 8;445(7128):648-51
17187052
Gut. 2007 Oct;56(10):1333-6
17872562
Eur J Immunol. 1996 Jul;26(7):1647-51
8766574
J Immunol. 2002 Dec 1;169(11):6554-63
12444167
Curr Opin Immunol. 2007 Jun;19(3):281-6
17433650
Mol Immunol. 2002 May;38(12-13):903-9
12009568
Arch Dermatol. 1972 Feb;105(2):197-207
5060862
J Exp Med. 2000 Jul 3;192(1):123-8
10880533
Arch Dermatol. 1990 Nov;126(11):1523
2241215
Nat Immunol. 2005 Nov;6(11):1069-70
16239919
Curr Opin Immunol. 2006 Dec;18(6):670-5
17010592
Gastroenterology. 2008 Oct;135(4):1130-41
18706417
J Exp Med. 2004 Jan 5;199(1):125-30
14707118
Cytokine Growth Factor Rev. 2002 Apr;13(2):155-68
11900991
N Engl J Med. 1979 Sep 6;301(10):555
460314