title: Clinical characteristics of tumors derived from colorectal cancer patients who harbor the tumor necrosis factor alpha-1031T/T and NOD2 3020insC polymorphism.
abstract: BACKGROUND
  Genetic predispositions to disease have focused on highly penetrant causative changes in tumor suppressor genes or genes associated with DNA mismatch repair. New investigations are revealing new genetic associations with disease that are more subtle in their association with disease and require characterization.
  
  
  METHODS
  In this report we have examined the tumor characteristics in a group of patients who have been shown to harbor two polymorphisms in two genes that are associated with the immune system NOD2 and TNFalpha.
  
  
  RESULTS
  Colorectal cancers from patients with NOD2 3020insC and TNFalpha-1031T/T constitutional changes are mostly right-sided disease (OR=2.21, p=0.03) with a tendency to higher stages (OR=2.41, p=0.06), increased number of associated polyps (OR=1.77, p=0.16) and later age of average age of disease onset (p=0.039).
  
  
  CONCLUSIONS
  The results reveal that there appear to be specific characteristics associated with the tumors that may aid in determining management strategies to reduce the risk of disease.
authors.affiliation: Department of General and Oncological Surgery, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Józef
authors.initials: J
authors.lastname: Kładny
authors.forename: Janina
authors.initials: J
authors.lastname: Suchy
authors.forename: Ewa
authors.initials: E
authors.lastname: Kłujszo-Grabowska
authors.forename: Tomasz
authors.initials: T
authors.lastname: Kacperski
authors.forename: Rodney J
authors.initials: RJ
authors.lastname: Scott
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Kurzawski
authors.forename: Jan
authors.initials: J
authors.lastname: Lubiński
mesh_terms: D000368:Aged; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D053473:Nod2 Signaling Adaptor Protein / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D011379:Prognosis; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
chemical_list: C429018:NOD2 protein, human; D053473:Nod2 Signaling Adaptor Protein; D014409:Tumor Necrosis Factor-alpha