Correlation of hepatic venous pressure gradient with variceal bleeding, size of esophageal varices, etiology, ascites and degree of liver dysfunction in cirrhosis of liver.
An elevated hepatic venous pressure gradient (HVPG) has been associated with risk of variceal bleeding, and outcome and survival after variceal bleeding. In this pilot study, we measured HVPG in 40 patients with liver cirrhosis and studied its relationship with etiology of liver disease, esophageal variceal size, history of variceal bleeding or ascites, biochemical liver tests and Child-Pugh class. There was no procedurerelated complication. The mean (SD) HVPG was similar in patients who had history of variceal bleeding as compared to those who did not (15.4 [2.8] mmHg vs. 13.9 [2.7] mmHg, p=0.1); HVPG had no significant association with etiology of cirrhosis (p=0.4). HVPG levels were significantly higher in patients with larger esophageal varices (grade III/IV vs. I/II: 15.2 [2.7] mmHg vs.13.1 [2.8] mmHg, p=0.04), poorer Child-Pugh class (B or C versus A), and presence of ascites (p=0.04). Thus, HVPG correlated with variceal size, Child-Pugh class, and presence of ascites, but not with variceal bleeding status.
Gulzar
Ghulam Mohamad
GM
Department of Gastroenterology, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, 190 011, India.
Zargar
Showkat Ali
SA
Jalal
Sheikh
S
Alaie
Mohamad Sultan
MS
Javid
Gul
G
Suri
Pawan Kumar
PK
Shah
Nisar Ahmad
NA
Bilal-Ul-Rehman
Hakeem
Mohamad Shafi
MS
Shoukat
Abid
A
Dar
Gulzar Ahmad
GA
D000293:Adolescent; D000328:Adult; D000368:Aged; D001201:Ascites / Q000209:etiology* / Q000503:physiopathology; D002405:Catheterization, Central Venous; D016099:Endoscopy, Gastrointestinal; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications* / Q000503:physiopathology; D017093:Liver Failure / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology*; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011379:Prognosis; D012189:Retrospective Studies; D012720:Severity of Illness Index; D014690:Venous Pressure / Q000502:physiology*; D055815:Young Adult
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