title: Differential involvement of prefrontal cortex, striatum, and hippocampus in DRL performance in mice.
abstract: Behavioral effects of neurotoxic lesions of the hippocampus, medial prefrontal (prelimbic, infralimbic and anterior cingulate) cortex or dorsal striatum were assessed using a DRL-10s schedule in mice. Post-operative acquisition data indicate that mice with hippocampal, but not prefrontal or striatal lesions received fewer reinforcements during daily 30-min sessions, and were less efficient in the timing of their responses. Additional analysis of inter-response-time (IRT) distributions revealed that the responses of hippocampal-lesioned mice exhibited undistinguishable responses for short IRTs (up to 9s). In addition, prefrontal-lesioned mice demonstrated a degradation of performance with further testing, and a flattened IRT distribution at late test phase, while striatal-lesioned mice behaved similarly to sham-lesioned mice. These results are interpreted in terms of known functions of the hippocampus in behavioral inhibition, and of the prefrontal cortex in executive control/decision making (and time production).
authors.affiliation: Centre de Neurosciences Intégratives et Cognitives, CNRS UMR 5228, Avenue des Facultés, 33405 Talence Cedex, France. y.cho@cnic.u-bordeaux1.fr
authors.forename: Yoon H
authors.initials: YH
authors.lastname: Cho
authors.forename: Yannick
authors.initials: Y
authors.lastname: Jeantet
mesh_terms: D000818:Animals; D003216:Conditioning, Operant / Q000502:physiology*; D003342:Corpus Striatum / Q000293:injuries / Q000502:physiology*; D003657:Decision Making / Q000502:physiology; D056344:Executive Function / Q000502:physiology; D006624:Hippocampus / Q000293:injuries / Q000502:physiology*; D007175:Impulsive Behavior / Q000503:physiopathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009483:Neuropsychological Tests; D017397:Prefrontal Cortex / Q000293:injuries / Q000502:physiology*; D011597:Psychomotor Performance / Q000502:physiology*; D012054:Reinforcement, Psychology; D013997:Time Factors