title: Daunorubicin and doxorubicin inhibit the [(11)C]choline accumulation in cancer cells.
abstract: We studied how very short (10-40min) incubation with anthracycline derivatives modifies the accumulation of PET tumor-diagnostic radiotracers in cancer cells. The human ovarian A2780 and A2780AD, human B lymphoid JY, human epidermoid KB-3-1 and KB-V-1, and smooth muscle DDT1 MF-2 cells were pre-incubated with daunorubicin and doxorubicin, and the uptake of [(18)F]FDG and [(11)C]choline was measured. Anthracycline treatment decreased remarkably the [(11)C]choline accumulation in a concentration dependent manner, while it did not modify significantly the [(18)F]FDG uptake of the cells.
authors.affiliation: Department of Nuclear Medicine, University of Debrecen, Medical and Health Science Centre, Debrecen, Hungary. pal@pet.dote.hu
authors.forename: Pál
authors.initials: P
authors.lastname: Mikecz
authors.forename: Teréz
authors.initials: T
authors.lastname: Márián
authors.forename: Tünde
authors.initials: T
authors.lastname: Miklovicz
authors.forename: László
authors.initials: L
authors.lastname: Galuska
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Krasznai
authors.forename: Agnes
authors.initials: A
authors.lastname: Tóth
authors.forename: Katalin
authors.initials: K
authors.lastname: Goda
authors.forename: Lajos
authors.initials: L
authors.lastname: Trón
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Hernádi
authors.forename: Zoárd T
authors.initials: ZT
authors.lastname: Krasznai
mesh_terms: D002250:Carbon Radioisotopes; D045744:Cell Line, Tumor; D002794:Choline / Q000378:metabolism*; D003630:Daunorubicin / Q000494:pharmacology*; D004317:Doxorubicin / Q000494:pharmacology*; D019788:Fluorodeoxyglucose F18; D006801:Humans
chemical_list: D002250:Carbon Radioisotopes; D019788:Fluorodeoxyglucose F18; D004317:Doxorubicin; D002794:Choline; D003630:Daunorubicin