The toxic effect of different concentrations of povidone iodine on the rabbit's cornea.
OBJECTIVE
To investigate the effects of polyvinylpyrrolidone (i.e., povidone) iodine (PVP-I) in different concentrations on the rabbit's cornea.


METHODS
PVP-I in various concentrations was instilled into the conjunctival sac and injected into the anterior chamber independently. The toxicity to the cornea was assessed by fluorescence dye, specular microscopy, and corneal pachymetry.


RESULTS
After conjunctival sac PVP-I instillation, severe epithelial damage was observed at the concentrations of 5.0% and 2.5%. After anterior chamber PVP-I injection, significant corneal edema was observed at the concentrations of 2.0% and 1.5%.


CONCLUSIONS
It can be safe and feasible to use 0.5% or 1.0% concentrations of PVP-I in conjunctival sac instillation for preoperative antisepsis.
Jiang
Jin
J
Department of Ophthalmology, Zhejiang Provincial People's Hospital, Hangzhou, China.
Wu
Miaoqin
M
Shen
Ting
T
D000818:Animals; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage / Q000633:toxicity*; D002452:Cell Count; D003228:Conjunctiva / Q000187:drug effects; D003315:Cornea / Q000187:drug effects* / Q000473:pathology / Q000601:surgery; D004305:Dose-Response Relationship, Drug; D004728:Endothelium, Corneal / Q000187:drug effects / Q000473:pathology; D019573:Epithelium, Corneal / Q000187:drug effects / Q000473:pathology; D009883:Ophthalmic Solutions; D013508:Ophthalmologic Surgical Procedures; D011206:Povidone-Iodine / Q000008:administration & dosage / Q000633:toxicity*; D011300:Preoperative Care; D011817:Rabbits; D018675:Toxicity Tests / Q000379:methods*
D000891:Anti-Infective Agents, Local; D009883:Ophthalmic Solutions; D011206:Povidone-Iodine