Need for related multipronged approaches to understand olfactory bulb signal processing.
Recent work from our laboratory in awake behaving animals shows that olfactory bulb processing changes depending profoundly on behavioral context. Thus, we find that when recording from the olfactory bulb in a mouse during a go-no go association learning task, it is not unusual to find a mitral cell that initially does not respond to the rewarded or unrewarded odors but develops a differential response to the stimuli during the learning session. This places a challenge on how to approach understanding of olfactory bulb processing, because neural interactions differ depending on the status of the animal. Here we address the question of how the different approaches to study olfactory bulb neuron responses, including studies in anesthetized and unanesthetized animals in vivo and recordings in slices, complement each other. We conclude that more critical understanding of the relationship between the measurements in the different preparations is necessary for future advances in the understanding of olfactory bulb processing of odor information.
Restrepo
Diego
D
Department of Cell and Developmental Biology, Neuroscience Program, and Rocky Mountain Taste and Smell Center, University of Colorado Denver School of Medicine, Aurora, Colorado 80045, USA. Diego.Restrepo@uchsc.edu
Whitesell
Jennifer
J
Doucette
Wilder
W
D000818:Animals; D001522:Behavior, Animal; D051379:Mice; D009812:Odorants; D009830:Olfactory Bulb / Q000502:physiology*; D055696:Olfactory Perception
Behav Neurosci. 1985 Oct;99(5):964-78
3843313
J Neurosci. 2006 Jan 25;26(4):1247-59
16436612
PLoS Biol. 2008 Oct 28;6(10):e258
18959481
J Physiol (Paris). 1980 Nov;76(6):551-8
7441566
Annu Rev Neurosci. 2006;29:163-201
16776583
Exp Neurol. 1987 May;96(2):430-42
3569465
J Neurosci. 2008 Sep 10;28(37):9227-38
18784303
J Neurosci. 2007 Feb 21;27(8):2091-101
17314304
J Neurophysiol. 1999 Oct;82(4):1786-92
10515968
Brain Res. 1978 Oct 13;154(2):301-6
687996
J Neurophysiol. 1989 Jun;61(6):1161-77
2746317
Curr Opin Neurobiol. 2003 Aug;13(4):476-81
12965296
J Neurosci. 2007 May 23;27(21):5621-32
17522307
Proc Natl Acad Sci U S A. 1995 Apr 11;92(8):3371-5
7724568
Behav Neurosci. 1986 Aug;100(4):585-96
3017376
J Neurophysiol. 2003 Mar;89(3):1623-39
12612023
J Neurophysiol. 1986 Dec;56(6):1571-89
3806183
Exp Brain Res. 1989;75(2):390-400
2721617
Trends Neurosci. 2005 Nov;28(11):620-7
16182387
PLoS Biol. 2007 Jul;5(7):e178
17608564
J Neurophysiol. 2004 Jun;91(6):2532-40
14960563
Exp Brain Res. 1988;69(2):378-86
3345814
Nat Neurosci. 1999 Nov;2(11):1003-9
10526340
J Comp Neurol. 2007 Jul 1;503(1):1-34
17480025
Neuron. 2006 Jun 15;50(6):937-49
16772174
Physiol Rev. 2006 Apr;86(2):409-33
16601265
J Neurophysiol. 1966 Jul;29(4):675-83
5966429
Cell. 1991 Apr 5;65(1):175-87
1840504
Neuron. 2006 Jan 19;49(2):271-83
16423700
Annu Rev Neurosci. 1996;19:517-44
8833453
J Physiol Paris. 2007 Jan-May;101(1-3):40-5
18054211
J Neurophysiol. 2008 Jul;100(1):422-30
18497360
Exp Brain Res. 1987;68(1):210-2
3691694
Nature. 1995 Jan 5;373(6509):33-6
7800036
Electroencephalogr Clin Neurophysiol. 1979 Jun;46(6):665-74
87311
Cell. 1999 Mar 5;96(5):713-23
10089886
PLoS Biol. 2006 Jun;4(6):e163
16689623
Physiol Behav. 1974 Feb;12(2):189-95
4816076
PLoS Biol. 2008 Apr 8;6(4):e82
18399719
Nat Neurosci. 2007 May;10(5):631-9
17450136
Neuron. 2008 Sep 11;59(5):802-14
18786363
J Neurosci. 2007 Oct 10;27(41):10969-81
17928438
Neuron. 2001 Dec 20;32(6):1165-79
11754845
Neuron. 2007 Mar 15;53(6):789-803
17359915
Nature. 2005 Mar 24;434(7032):470-7
15724148
Trends Neurosci. 2003 Sep;26(9):501-6
12948662
J Neurosci. 2006 Aug 23;26(34):8857-65
16928875
Nat Neurosci. 2008 Jan;11(1):80-7
18084286