title: Intensity of renal replacement therapy in acute kidney injury: perspective from within the Acute Renal Failure Trial Network Study.
abstract: Determination of the optimal dose of renal replacement therapy in critically ill patients with acute kidney injury has been controversial. Questions have recently been raised regarding the design and execution of the US Department of Veterans Affairs/National Institutes of Health Acute Renal Failure Trial Network (ATN) Study, which demonstrated no improvement in 60-day all-cause mortality with more intensive management of renal replacement therapy. In the present article we present our rationale for these aspects of the design and conduct of the study, including our use of both intermittent and continuous modalities of renal support, our approach to initiation of study therapy and the volume management during study therapy. In addition, the article presents data on hypotension during therapy and recovery of kidney function in the perspective of other studies of renal support in acute kidney injury. Finally, we address the implications of the ATN Study results for clinical practice from the perspective of the study investigators.
authors.affiliation: VA Pittsburgh Healthcare System, University Drive, Pittsburgh, PA 15240, USA. Palevsky@pitt.edu
authors.forename: Paul M
authors.initials: PM
authors.lastname: Palevsky
authors.forename: Theresa Z
authors.initials: TZ
authors.lastname: O'Connor
authors.forename: Glenn M
authors.initials: GM
authors.lastname: Chertow
authors.forename: Susan T
authors.initials: ST
authors.lastname: Crowley
authors.forename: Jane Hongyuan
authors.initials: JH
authors.lastname: Zhang
authors.forename: John A
authors.initials: JA
authors.lastname: Kellum
mesh_terms: D058186:Acute Kidney Injury / Q000401:mortality / Q000628:therapy*; D003422:Critical Care; D006801:Humans; D007022:Hypotension / Q000209:etiology; D015337:Multicenter Studies as Topic; D017063:Outcome Assessment, Health Care; D016032:Randomized Controlled Trials as Topic; D006435:Renal Dialysis / Q000379:methods*; D012107:Research Design; D014481:United States / Q000453:epidemiology; D014493:United States Department of Veterans Affairs
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