Mitochondrial (dys)function in adipocyte (de)differentiation and systemic metabolic alterations.
In mammals, adipose tissue, composed of BAT and WAT, collaborates in energy partitioning and performs metabolic regulatory functions. It is the most flexible tissue in the body, because it is remodeled in size and shape by modifications in adipocyte cell size and/or number, depending on developmental status and energy fluxes. Although numerous reviews have focused on the differentiation program of both brown and white adipocytes as well as on the pathophysiological role of white adipose tissues, the importance of mitochondrial activity in the differentiation or the dedifferentiation programs of adipose cells and in systemic metabolic alterations has not been extensively reviewed previously. Here, we address the crucial role of mitochondrial functions during adipogenesis and in mature adipocytes and discuss the cellular responses of white adipocytes to mitochondrial activity impairment. In addition, we discuss the increase in scientific knowledge regarding mitochondrial functions in the last 10 years and the recent suspicion of mitochondrial dysfunction in several 21st century epidemics (ie, obesity and diabetes), as well as in lipodystrophy found in HIV-treated patients, which can contribute to the development of new therapeutic strategies targeting adipocyte mitochondria.
De Pauw
Aurélia
A
Laboratory of Biochemistry and Cell Biology, University of Namur, 61 rue de Bruxelles, Namur, Belgium.
Tejerina
Silvia
S
Raes
Martine
M
Keijer
Jaap
J
Arnould
Thierry
T
D017667:Adipocytes / Q000166:cytology / Q000502:physiology*; D050156:Adipogenesis / Q000502:physiology*; D000818:Animals; D054337:Cell Dedifferentiation / Q000502:physiology; D054338:Cell Transdifferentiation / Q000502:physiology; D005947:Glucose / Q000378:metabolism; D015658:HIV Infections / Q000503:physiopathology; D039682:HIV-Associated Lipodystrophy Syndrome / Q000209:etiology / Q000378:metabolism / Q000628:therapy; D006801:Humans; D050356:Lipid Metabolism / Q000502:physiology; D050155:Lipogenesis / Q000502:physiology; D051379:Mice; D008928:Mitochondria / Q000502:physiology*; D009765:Obesity / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy
D005947:Glucose
Cell Metab. 2008 Nov;8(5):347-58
19046567
J Am Diet Assoc. 2005 Mar;105(3):428-40
15746832
Am J Physiol. 1996 May;270(5 Pt 1):E768-75
8967464
Nature. 2007 Nov 29;450(7170):712-6
18046409
Cell Metab. 2005 Jun;1(6):393-9
16054088
Nat Rev Mol Cell Biol. 2005 Mar;6(3):248-61
15738989
Diabetes. 2006 Jun;55(6):1792-9
16731844
J Biol Chem. 2005 Jul 1;280(26):25250-7
15878856
Curr Opin Lipidol. 2008 Feb;19(1):4-10
18196980
Diabetes. 2002 Aug;51(8):2459-66
12145158
Adv Exp Med Biol. 2000;475:143-52
10849656
J Am Coll Nutr. 2007 Aug;26(4):389S-395S
17906192
Eur J Biochem. 2002 Jan;269(1):19-28
11784294
J Biol Chem. 2002 Jan 25;277(4):2773-8
11707458
J Biol Chem. 2003 Aug 29;278(35):33370-6
12807871
Am J Physiol Endocrinol Metab. 2005 Oct;289(4):E617-26
15941786
Cell. 2006 Dec 15;127(6):1109-22
17112576
J Clin Invest. 2006 Jan;116(1):125-36
16374519
Dev Cell. 2002 Mar;2(3):331-41
11879638
J Biol Chem. 2004 Sep 24;279(39):40462-9
15265861
Int J Obes Relat Metab Disord. 2000 Nov;24 Suppl 4:S3-7
11126237
Nature. 2000 Jul 27;406(6794):415-8
10935638
Mol Pharmacol. 2006 Sep;70(3):779-85
16760360
Biochem Biophys Res Commun. 2007 Jul 6;358(3):813-8
17512501
J Biol Chem. 2007 May 25;282(21):15439-50
17416903
J Biol Chem. 2002 Sep 6;277(36):32892-8
12093799
Mol Endocrinol. 1997 Jan;11(1):27-38
8994185
Cell Metab. 2005 Jun;1(6):409-14
16054090
J Biol Chem. 1998 Jul 31;273(31):19834-9
9677418
Annu Rev Biochem. 1995;64:345-73
7574486
Int J Obes Relat Metab Disord. 2000 Nov;24 Suppl 4:S8-10
11126248
Apoptosis. 2003 Aug;8(4):327-35
12815275
J Clin Endocrinol Metab. 2007 Apr;92(4):1467-73
17244782
Diabetes Obes Metab. 2007 May;9(3):259-75
17391151
Mol Cell Biol. 2003 Feb;23(3):1085-94
12529412
J Agric Food Chem. 2008 Feb 13;56(3):642-6
18211021
Proc Natl Acad Sci U S A. 2004 Jun 1;101(22):8437-42
15155905
FEBS Lett. 2006 Jul 24;580(17):4126-30
16828089
J Lipid Res. 2005 Jun;46(6):1133-49
15741651
Biochem J. 2006 Sep 1;398(2):153-68
16898874
Nat Genet. 2000 Dec;26(4):435-9
11101840
Antivir Ther. 2006;11(6):729-40
17310817
Am J Physiol Endocrinol Metab. 2004 Oct;287(4):E799-803
15198934
J Clin Invest. 2004 Nov;114(9):1281-9
15520860
FASEB J. 2000 Sep;14(12):1793-800
10973929
Science. 1999 Mar 5;283(5407):1482-8
10066162
FEBS Lett. 2008 Jan 9;582(1):117-31
18037376
Nat Med. 2004 Jun;10(6):633-7
15146178
J Biol Chem. 2004 Apr 9;279(15):15130-41
14722061
Cell Metab. 2006 May;3(5):333-41
16679291
Novartis Found Symp. 2007;287:60-3; discussion 63-9
18074631
Nat Rev Mol Cell Biol. 2008 May;9(5):367-77
18401346
Mol Cell Biochem. 2004 Dec;267(1-2):157-66
15663197
J Endocrinol Invest. 2002 Nov;25(10):823-35
12508945
Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):2058-63
14769942
Diabetes. 2005 May;54(5):1392-9
15855325
Trends Endocrinol Metab. 2006 Aug;17(6):243-50
16815031
Antivir Ther. 2007;12(1):97-105
17503753
Cell. 2006 Jun 30;125(7):1241-52
16814712
Cell Death Differ. 2006 Dec;13(12):2154-6
16691210
J Cell Physiol. 2008 Apr;215(1):210-22
18064604
J Biol Chem. 2002 Jan 11;277(2):1426-32
11694510
J Cell Sci. 2009 Jan 1;122(Pt 1):145-55
19066287
Cell Mol Life Sci. 2006 Dec;63(23):2847-58
17103110
Proc Natl Acad Sci U S A. 2004 Nov 30;101(48):16801-6
15556998
Cell Metab. 2005 Jun;1(6):401-8
16054089
Nat Med. 2005 Jul;11(7):797-803
15965483
Obesity (Silver Spring). 2006 Aug;14 Suppl 5:242S-249S
17021375
Nat Rev Mol Cell Biol. 2007 Nov;8(11):870-9
17928812
Mol Cell Biochem. 2004 Jul;262(1-2):1-16
15532704
Eur J Gastroenterol Hepatol. 2004 Nov;16(11):1095-105
15489566
Mol Aspects Med. 2004 Aug;25(4):365-451
15302203
Nature. 1996 Aug 15;382(6592):622-6
8757131
Nature. 2006 Nov 16;444(7117):337-42
17086191
Diabetes. 2002 Mar;51(3):624-30
11872659
Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):625-30
11792850
Nat Genet. 2003 Jul;34(3):267-73
12808457
Obes Rev. 2001 Nov;2(4):255-65
12119996
Biochemistry. 2003 Feb 4;42(4):971-9
12549917
Minerva Med. 2008 Jun;99(3):241-51
18497722
N Engl J Med. 2009 Apr 9;360(15):1500-8
19357405
Mol Cell Biol. 2000 Oct;20(19):7292-9
10982846
Science. 2003 May 16;300(5622):1140-2
12750520
Clin Sci (Lond). 1997 Jan;92(1):3-11
9038586
EMBO J. 2002 Jan 15;21(1-2):53-63
11782425
Trends Pharmacol Sci. 2005 Feb;26(2):88-93
15681026
Mol Cell Biochem. 1976 Aug 30;12(2):113-25
958214
Science. 2005 Jan 21;307(5708):384-7
15662004
AIDS. 2004 Nov 5;18(16):2127-36
15577645
Horm Res. 2006;65(6):300-10
16641553
PLoS Genet. 2007 Feb 23;3(2):e24
17319745
Endocrinology. 2006 Nov;147(11):5325-32
16840543
Int J Obes Relat Metab Disord. 2004 Jan;28(1):176-9
14557831
Antivir Ther. 2006;11(1):25-34
16518957
Diabetologia. 2005 Nov;48(11):2365-75
16205884
Int J Obes (Lond). 2007 Dec;31(12):1763-76
17653062
Annu Rev Cell Dev Biol. 2000;16:145-71
11031233
Mol Cell. 1999 Oct;4(4):597-609
10549291
Circ Res. 2005 Jun 10;96(11):1200-7
15905464
Obesity (Silver Spring). 2006 Mar;14(3):388-97
16648609
J Lipid Res. 2007 Sep;48(9):1905-14
17699733
Genes Dev. 2004 Aug 15;18(16):1970-5
15289464
Nature. 2006 Dec 14;444(7121):847-53
17167472
J Clin Invest. 2006 Oct;116(10):2791-8
16981010
J Biol Chem. 2004 Aug 20;279(34):35914-22
15192111
FEBS Lett. 2003 Aug 28;550(1-3):163-7
12935904
Pharmacol Res Commun. 1974 Feb;6(1):1-21
4372642
Diabetes. 1998 Dec;47(12):1948-52
9836529
J Clin Invest. 1995 Dec;96(6):2914-23
8675663
Diabetes. 2007 Jul;56(7):1751-60
17456854
Mol Genet Metab. 2005 May;85(1):46-53
15862280
Drugs. 1999 Oct;58(4):743-60
10551441
Drug Discov Today. 2005 Sep 15;10(18):1219-30
16213414
Curr Opin Investig Drugs. 2008 Apr;9(4):371-8
18393104
J Cell Sci. 2006 Apr 1;119(Pt 7):1266-82
16537646
J Lipid Res. 1969 Jan;10(1):77-82
5764119
J Endocrinol. 2003 Jun;177(3):351-5
12773114
J Lipid Res. 2007 Apr;48(4):826-36
17202129
Diabetes. 2007 Dec;56(12):2973-81
17827403
Biochem Biophys Res Commun. 2007 Dec 28;364(4):972-7
17967414
Nature. 2004 May 27;429(6990):417-23
15164064
Nature. 2008 Aug 21;454(7207):961-7
18719582
Nat Clin Pract Endocrinol Metab. 2007 Sep;3(9):651-61
17710086
Trends Endocrinol Metab. 2003 Dec;14(10):439-41
14643055
J Clin Invest. 2004 Dec;114(12):1752-61
15599400
Nat Med. 2006 Jan;12(1):75-80
16397575
N Engl J Med. 2009 Apr 9;360(15):1518-25
19357407