Variations in Hedgehog signaling: divergence and perpetuation in Sufu regulation of Gli.
The Hedgehog (Hh) proteins play a universal role in metazoan development. Nevertheless, fundamental differences exist between Drosophila and vertebrates in the transduction of the Hh signal, notably regarding the role of primary cilia in mammalian cells. In this issue of Genes & Development, Chen and colleagues (pp. 1910-1928) demonstrate that mouse Suppressor of fused (Sufu) regulates the stability of the transcription factors Gli2 and Gli3 by antagonizing the conserved Gli degradation device mediated by Hib/Spop in a cilia-independent manner.
Ruel
Laurent
L
Institut Biologie du Développement et Cancer-IBDC, Université de Nice-Sophia Antipolis, CNRS UMR 6543, Centre de Biochimie, Nice Cedex 02, France.
Thérond
Pascal P
PP
D000818:Animals; D002923:Cilia / Q000502:physiology; D019143:Evolution, Molecular; D005786:Gene Expression Regulation; D053823:Hedgehog Proteins / Q000502:physiology*; D051741:Kruppel-Like Transcription Factors / Q000378:metabolism*; D051379:Mice; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009687:Nuclear Proteins / Q000378:metabolism; D055550:Protein Stability; D012097:Repressor Proteins / Q000378:metabolism*; D015398:Signal Transduction; D043743:Ubiquitin-Protein Ligase Complexes; D000075746:Zinc Finger Protein Gli2; D000074290:Zinc Finger Protein Gli3
C000618551:Gli2 protein, mouse; C465571:Gli3 protein, mouse; D053823:Hedgehog Proteins; D051741:Kruppel-Like Transcription Factors; D009419:Nerve Tissue Proteins; D009687:Nuclear Proteins; D012097:Repressor Proteins; C490763:Sufu protein, mouse; D000075746:Zinc Finger Protein Gli2; D000074290:Zinc Finger Protein Gli3; C509762:Spop protein, mouse; D043743:Ubiquitin-Protein Ligase Complexes
J Biol Chem. 2006 Sep 29;281(39):28584-95
16867986
Curr Biol. 2009 Aug 11;19(15):1320-6
19592253
Genes Dev. 2009 Aug 15;23(16):1910-28
19684112
Nature. 2004 Nov 18;432(7015):324-31
15549094
Nat Cell Biol. 2003 Oct;5(10):907-13
14523402
Dev Cell. 2006 Feb;10(2):187-97
16459298
Nature. 1980 Oct 30;287(5785):795-801
6776413
Dev Cell. 2006 Feb;10(2):177-86
16459297
Dev Biol. 2006 Jun 1;294(1):258-70
16595130
Proc Natl Acad Sci U S A. 2006 May 30;103(22):8408-13
16707575
Dev Cell. 2006 Jun;10(6):719-29
16740475
Dev Cell. 2007 Oct;13(4):481-95
17925225
Cell. 2008 May 2;133(3):537-48
18455992
Dev Biol. 2009 Jun 15;330(2):452-60
19371734
Mol Cell Biol. 2005 Aug;25(16):7054-68
16055717
Mol Cell Biol. 2005 Aug;25(16):7042-53
16055716
Nat Cell Biol. 1999 Sep;1(5):312-9
10559945
Genes Dev. 2000 Nov 15;14(22):2893-905
11090136
Sci Signal. 2008 Sep 30;1(39):ra7
18827223
Development. 2000 Sep;127(18):4001-10
10952898
Dev Cell. 2005 Feb;8(2):267-78
15691767
Science. 2007 Jul 20;317(5836):372-6
17641202
Sci Signal. 2009 Jun 23;2(76):ra29
19549984
Development. 2006 Jan;133(1):3-14
16339192
Development. 2005 Feb;132(4):625-34
15647323
Development. 2007 Oct;134(20):3677-89
17881487
Nature. 2009 May 7;459(7243):98-102
19305393
Trends Cell Biol. 2007 Sep;17(9):438-47
17845852
Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5442-7
11960000
Nature. 2002 Aug 22;418(6900):892-7
12192414
Mol Cell. 2003 Nov;12(5):1261-74
14636583
Nature. 1998 Dec 24-31;396(6713):749-53
9874371
Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3196-201
19218434
Genetics. 1992 Nov;132(3):725-36
1468628
Development. 2005 Oct;132(19):4407-17
16155214
Curr Top Dev Biol. 2003;53:1-114
12509125