title: Evaluation of effects of topic melatonin on implant surface at 5 and 8 weeks in Beagle dogs.
abstract: OBJECTIVE
  The aim of this study was to evaluate the effect of the topical application of melatonin on osteointegration of dental implants in Beagle dogs 5 and 8 weeks after their insertion.
  
  
  METHODS
  For subsequent insertion of dental implants, upper and lower premolars and molars were extracted from 12 Beagle dogs. Each mandible received cylindrical screw implants of 3.25 mm in diameter and 10 mm in length. The implants were randomly assigned to the mesial and distal sites on each side of the mandible. Prior to implanting, 1.2 mg lyophylized powder melatonin was applied to one bone hole at each side of the mandible. None was applied at the control sites. Eight histological sections per implant were obtained for histomorphometric studies.
  
  
  RESULTS
  After 5- and 8-week treatment periods, melatonin significantly increased the inter-thread bone (p < 0.05) and new bone formation (p < 0.05) in comparison to control implants in both weeks. There were no significant increases in the bone-to-implant contact and peri-implant bone (p > 0.05).
  
  
  CONCLUSIONS
  Topical application of melatonin may act as a biomimetic agent in the placement of endo-osseous dental implants at 5 and 8 weeks after the implantation.
authors.affiliation: Department of Dentistry, University of Granada, Granada, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Guardia
authors.forename: Gerardo
authors.initials: G
authors.lastname: Gómez-Moreno
authors.forename: María José
authors.initials: MJ
authors.lastname: Ferrera
authors.forename: Antonio
authors.initials: A
authors.lastname: Cutando
mesh_terms: D000287:Administration, Topical; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage*; D001641:Bicuspid / Q000601:surgery; D040761:Biomimetic Materials / Q000008:administration & dosage; D015519:Bone Density / Q000187:drug effects; D003758:Dental Implantation, Endosseous / Q000379:methods; D015921:Dental Implants; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D008297:Male; D008334:Mandible / Q000187:drug effects / Q000473:pathology; D008550:Melatonin / Q000008:administration & dosage*; D008963:Molar / Q000601:surgery; D016348:Osseointegration / Q000187:drug effects*; D010012:Osteogenesis / Q000187:drug effects; D011897:Random Allocation; D013997:Time Factors; D014081:Tooth Extraction; D020390:Tooth Socket / Q000187:drug effects / Q000473:pathology; D014945:Wound Healing / Q000502:physiology
chemical_list: D000975:Antioxidants; D015921:Dental Implants; D008550:Melatonin