title: Duloxetine for the treatment of recurrent major depressive disorder in elderly patients: treatment outcomes in patients with comorbid arthritis.
abstract: BACKGROUND
  Evaluation and treatment of major depression (MDD) in elderly patients is frequently complicated by the presence of comorbid medical conditions, which can reduce the effect of depression treatment, leading to lower rates of depressive-symptom improvement and higher rates of relapse.
  
  
  OBJECTIVE
  The authors investigated results of antidepressant concurrent with arthritis pain treatment in elderly patients.
  
  
  METHODS
  Patients age 65 and over with recurrent MDD were stratified by arthritis status and randomized to duloxetine (a dual reuptake-inhibitor of serotonin and norepinephrine) or placebo treatment for 8 weeks (duloxetine, N=117; placebo, N=55).
  
  
  RESULTS
  Duloxetine significantly reduced MDD symptom severity in elderly patients with and without arthritis, and produced significant reduction in several pain measures in those patients with comorbid arthritis.
  
  
  CONCLUSIONS
  The magnitude and time-course of depressive symptom improvement did not differ significantly between patients with and without arthritis. Some studies have suggested that the severity of pain in arthritis patients may be linked to depression severity.
authors.affiliation: correspondence and M.D., Eli Lilly and Company, Lilly Corporate Center, Drop Code 4103, Indianapolis, IN 46285, USA. mwmd@lilly.com
authors.forename: Madelaine M
authors.initials: MM
authors.lastname: Wohlreich
authors.forename: Mark D
authors.initials: MD
authors.lastname: Sullivan
authors.forename: Craig H
authors.initials: CH
authors.lastname: Mallinckrodt
authors.forename: Amy S
authors.initials: AS
authors.lastname: Chappell
authors.forename: Tina M
authors.initials: TM
authors.lastname: Oakes
authors.forename: John G
authors.initials: JG
authors.lastname: Watkin
authors.forename: Joel
authors.initials: J
authors.lastname: Raskin
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D000928:Antidepressive Agents / Q000627:therapeutic use*; D001168:Arthritis / Q000150:complications; D003866:Depressive Disorder / Q000150:complications / Q000188:drug therapy*; D004311:Double-Blind Method; D000068736:Duloxetine Hydrochloride; D005260:Female; D006801:Humans; D008297:Male; D010919:Placebos; D012008:Recurrence; D013876:Thiophenes / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents; D010919:Placebos; D013876:Thiophenes; D000068736:Duloxetine Hydrochloride