Production of autoantibodies to glutamate during Alzheimer's dementia.
Increased production of autoantibodies to glutamate was found in blood plasma from patients with Alzheimer's dementia. The content of autoantibodies to glutamate in patients with early-onset Alzheimer's disease was much lower than in those with late-onset Alzheimer's disease (1.40+/-0.07 and 1.80+/-0.07 arb. units, p<0.001). The level of autoantibodies to glutamate in patients with mixed - Alzheimer's disease was 1.60+/-0.01 arb. units.
Davydova
T V
TV
Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, N. A. Alekseev Moscow Clinical Psychiatric Hospital No. 1, Moscow. dav-ta@yandex.ru
Voskresenskaya
N I
NI
Gorbatov
V Yu
VY
Fomina
V G
VG
Doronina
O A
OA
Maksunova
I V
IV
D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood* / Q000453:epidemiology / Q000276:immunology*; D000704:Analysis of Variance; D001323:Autoantibodies / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D018698:Glutamic Acid / Q000097:blood* / Q000276:immunology*; D006801:Humans
D001323:Autoantibodies; D018698:Glutamic Acid