Acute kidney injury in the elderly population.
The elderly population is more prone to acute kidney injury (AKI) than younger populations. Older patients have less renal reserve because of reduced glomerular filtration rates due to anatomic/functional changes, and concomitant diseases such as hypertension, diabetes, atherosclerosis, heart failure, ischemic renal disease, and obstructive uropathy. The risk of AKI may also increase as a result of aggressive diagnostic and therapeutic procedures, which include medical agents, radiology, and surgical intervention. AKI in the elderly has a multifactorial physiopathology due to different etiologies. Studies that have specifically compared prognosis of AKI in elderly versus young over the recent years suggest that age is a predictor of long-term outcome. In most cases, the treatment of AKI is similar for all age groups. The majority of critically ill patients with AKI will eventually need renal replacement therapy (RRT). The influence of RRT on renal outcome remains a subject of intense investigation and debate. Avoiding situations that could damage the kidney is an important strategy to prevent AKI development in the elderly, besides medical and interventional therapeutics.
Yilmaz
Rahmi
R
School of Medicine, Nephrology Department, Hacettepe University, 06100, Ankara, Turkey.
Erdem
Yunus
Y
D058186:Acute Kidney Injury / Q000209:etiology / Q000628:therapy; D000368:Aged; D006801:Humans; D011379:Prognosis
J Am Coll Nutr. 1983;2(1):33-44
6411791
Curr Opin Crit Care. 2003 Dec;9(6):496-502
14639069
Contrib Nephrol. 2001;(132):258-65
11395894
Ann Pharmacother. 2002 Jun;36(6):1068-74
12022910
Int Urol Nephrol. 2001;32(4):539-47
11989542
Crit Care. 2004 Oct;8(5):325-6
15469592
Crit Care Med. 2003 Oct;31(10):2421-8
14530746
BMJ. 1993 Feb 20;306(6876):481-3
8448456
JAMA. 2005 Aug 17;294(7):813-8
16106006
J Clin Epidemiol. 2001 Jul;54(7):661-74
11438406
Am J Kidney Dis. 2002 Aug;40(2):275-9
12148099
Ren Fail. 1996 Jul;18(4):601-5
8875685
Intensive Care Med. 2001 Nov;27(11):1685-8
11810109
Medicine (Baltimore). 2008 Jul;87(4):203-209
18626303
Am J Kidney Dis. 2007 Sep;50(3):371-8
17720516
Am Surg. 2005 Jan;71(1):36-9
15757054
Crit Care Med. 1990 Jan;18(1):29-31
2104581
Am J Kidney Dis. 1991 Feb;17(2):191-8
1992662
Intensive Care Med. 2000 Apr;26(4):400-6
10872131
Am J Med. 1999 Apr;106(4):459-65
10225250
Int Urol Nephrol. 2001;32(4):531-7
11989541
Int Urol Nephrol. 2008;40(2):453-60
18368506
JAMA. 2002 Nov 27;288(20):2547-53
12444861
Exp Gerontol. 1982;17(5):321-31
7169092
J Am Soc Nephrol. 1998 Apr;9(4):710-8
9555674
Nephron. 1984;36(3):169-72
6700808
Kidney Int. 1996 Sep;50(3):811-8
8872955
J Appl Behav Anal. 1984 Fall;17(3):397-401
6511704
Int Urol Nephrol. 2002;34(1):151-7
12549659
Nephrol Dial Transplant. 1999 Nov;14(11):2570-3
10534488
Int Urol Nephrol. 2007;39(1):339-44
17203349
Crit Care Clin. 2005 Apr;21(2):223-37
15781159
Kidney Int. 2001 Mar;59(3):1052-8
11231360
Ren Fail. 2006;28(7):549-55
17050237
Am J Pathol. 1995 Mar;146(3):742-52
7887455
Curr Opin Crit Care. 2006 Dec;12(6):561-6
17077687
Int Urol Nephrol. 2010 Mar;42(1):273-7
19277890
Kidney Int. 2006 May;69(10):1806-13
16598197
Nephrol Dial Transplant. 1995 Nov;10(11):1992-2000
8643157
Curr Opin Crit Care. 2006 Dec;12(6):544-50
17077684
Int Urol Nephrol. 2009;41(3):629-34
19137409
J Urol. 1977 Nov;118(5):707-10
410950
Am J Physiol. 1994 Dec;267(6 Pt 2):F1059-62
7810692
Nephrol Dial Transplant. 1987;2(5):316-22
3122108
Int Urol Nephrol. 2009 Dec;41(4):933-9
18696251
Crit Care. 2005;9(6):R700-9
16280066
Intensive Care Med. 2000 Dec;26(12):1824-31
11271091
Clin Nephrol. 2005 May;63(5):335-45
15909592
Crit Care Med. 2008 May;36(5):1397-403
18434915
J Am Soc Nephrol. 1996 Jul;7(7):1045-51
8829120
Nephrol Dial Transplant. 2006 May;21(5):1248-52
16449291
Int Urol Nephrol. 2006;38(2):391-6
16868717
Blood Purif. 2009;27(3):261-70
19218794
Am J Kidney Dis. 2004 Sep;44(3):402-9
15332212
Int Urol Nephrol. 2006;38(2):381-5
16868715
Ann Intern Med. 1999 Mar 16;130(6):461-70
10075613
FASEB J. 2003 May;17(8):908-10
12670885
Nephrol Dial Transplant. 2000 Feb;15(2):212-7
10648667
Int Urol Nephrol. 2009 Dec;41(4):919-26
19031110
Contrib Nephrol. 1993;105:98-101
8252879
N Engl J Med. 2006 Feb 2;354(5):449-61
16452557
Crit Care Med. 1991 Jan;19(1):8-11
1986894
IDrugs. 2000 Oct;3(10):1206-16
16049842
Am J Kidney Dis. 2000 Mar;35(3):433-47
10692269
N Engl J Med. 2002 Jan 31;346(5):305-10
11821506
Minerva Anestesiol. 2007 Nov;73(11):559-65
17952028
Int Urol Nephrol. 2008;40(3):855-8
18587662
Am J Kidney Dis. 2002 May;39(5):930-6
11979336
J Am Geriatr Soc. 2005 Apr;53(4):660-5
15817014
Arch Intern Med. 1986 Sep;146(9):1790-6
3530166
Int Urol Nephrol. 2008;40(3):731-9
18368509
Int Urol Nephrol. 2006;38(3-4):759-65
17245550
Artif Organs. 1996 Mar;20(3):281
8694703
J Am Soc Nephrol. 1996 Aug;7(8):1106-22
8866401
Ren Fail. 2007;29(2):163-8
17365931
Int Urol Nephrol. 2003;35(2):283-8
15072510
Int J Artif Organs. 2007 Apr;30(4):281-92
17520564
Geriatr Nephrol Urol. 1999;9(3):153-65
10701138
J Intensive Care Med. 2008 May-Jun;23(3):195-203
18474503
Nephrol Dial Transplant. 2008 Jul;23(7):2235-41
18408072
Int Urol Nephrol. 2009 Dec;41(4):967-72
19280360
Am J Kidney Dis. 1993 Dec;22(6):759-82
8250022
Nephrol Dial Transplant. 2009 Feb;24(2):512-8
18854418
Lancet. 2000 Jul 1;356(9223):26-30
10892761
Crit Care Med. 2003 Feb;31(2):449-55
12576950
Crit Care. 2006;10(3):R73
16696865
J Ren Nutr. 2005 Jan;15(1):63-70
15648010
J Urol. 2003 Aug;170(2 Pt 1):480-4
12853804
Kidney Int. 1997 Apr;51(4):1196-204
9083286
CMAJ. 2004 Jan 20;170(2):197-204
14734433
Arch Intern Med. 2001 Jan 22;161(2):272-6
11176743
Crit Care Resusc. 2007 Mar;9(1):60-8
17352669
J Am Geriatr Soc. 1998 Jun;46(6):721-5
9625188
Nephrol Dial Transplant. 2007 Sep;22(9):2513-9
17517795
J Am Coll Cardiol. 2007 Feb 13;49(6):716-26
17291938
J Am Soc Nephrol. 2004 Aug;15(8):2115-24
15284297
Scott Med J. 1992 Dec;37(6):175-8
1492213
Kidney Int. 2001 Sep;60(3):1154-63
11532112
Int Urol Nephrol. 2006;38(3-4):787-93
17160631
Kidney Int. 2004 Feb;65(2):649-53
14717937
Am J Physiol Renal Physiol. 2004 Oct;287(4):F797-805
15213068
Am J Kidney Dis. 2007 Nov;50(5):712-20
17954284
Scand J Clin Lab Invest. 1989 Nov;49(7):641-6
2609107
J Am Geriatr Soc. 1994 Sep;42(9):968-71
8064106
J Am Geriatr Soc. 1990 Jan;38(1):25-30
2295766
Nephrol Dial Transplant. 2005 Aug;20(8):1630-7
15886217
Crit Care. 2004 Aug;8(4):R204-12
15312219
Arch Intern Med. 1987 Aug;147(8):1430-3
3453695
Int Urol Nephrol. 2002;34(2):255-6
12775107
Can J Anaesth. 2005 Mar;52(3):327-32
15753507
Kidney Int Suppl. 2008 Apr;(108):S87-93
18379555
Am J Pathol. 1990 Feb;136(2):429-39
2305836
Semin Nephrol. 1995 Sep;15(5):463-7
8525149
Am J Kidney Dis. 2008 Aug;52(2):262-71
18511164
Nephron Clin Pract. 2008;109(4):c182-7
18802365
Adv Ren Replace Ther. 1995 Apr;2(2):160-3
7614347
Arch Intern Med. 2000 May 8;160(9):1309-13
10809034
Clin J Am Soc Nephrol. 2008 May;3(3):674-81
18354075
Am J Kidney Dis. 2004 Dec;44(6):1000-7
15558520
Kidney Int. 2003 Oct;64(4):1417-24
12969161
Transplant Proc. 2007 Mar;39(2):421-3
17362746
Int Urol Nephrol. 2009;41(3):727-31
19115077
Crit Care Med. 2004 Aug;32(8):1669-77
15286542
Nephron. 2002 Jul;91(3):406-15
12119470
Mayo Clin Proc. 2000 Nov;75(11):1141-7
11075743
J Nephrol. 2008 Sep-Oct;21(5):645-56
18949718
Am J Kidney Dis. 1993 Jun;21(6):659-62
8503421
Reproduction. 2003 Jul;126(1):91-9
12814351