title: Comparison of shape-based analysis of retinal nerve fiber layer data obtained From OCT and GDx-VCC.
abstract: OBJECTIVE
  To directly compare in 1 population: (1) the performance of Optical Coherence Tomograph (OCT) and GDx-Variable Corneal Compensator (VCC) when using Wavelet-Fourier Analysis (WFA) and Fast-Fourier Analysis (FFA), (2) the performance of these shape-based and standard metrics, and (3) the shape of the retinal nerve fiber layer (RNFL) temporal, superior, nasal, inferior, temporal (TSNIT) curves obtained by the 2 different devices.
  
  
  METHODS
  RNFL estimates were obtained from 136 eyes of 136 individuals (73 healthy and 63 mild glaucoma). WFA and FFA with and without asymmetry measures were performed on the TSNIT RNFL estimates to identify glaucoma from healthy eyes. Performance of WFA, FFA, and the standard metrics of OCT (Inferior Average) and GDX-VCC (Nerve Fiber Indicator) was evaluated by calculating receiver operating characteristic area. Measurements were obtained at a custom radius (33 to 41 pixels) for GDx-VCC to match the OCT radius (1.73 mm).
  
  
  RESULTS
  WFA and FFA shape analysis significantly improved performance of both OCT (0.937) and GDx-VCC (0.913) compared with Inferior Average and Nerve Fiber Indicator (0.852 and 0.833, respectively). With either shape-based or standard metrics, OCT performance was slightly, but not significantly, better than GDx-VCC performance. Comparison of RNFL curves revealed that the GDx-VCC curves were more jagged and the peaks shifted more nasally when compared with the OCT RNFL curves.
  
  
  CONCLUSIONS
  Performance of both OCT and GDx-VCC devices are improved by shape-based analysis methods. Classification performance was greater when using WFA for the OCT, and greater with FFA for the GDx-VCC. Significant differences between the machines exist in the measured TSNIT thicknesses, possibly because of GDx-VCC's measurements being affected by polarization magnitude varying with angle.
authors.affiliation: Department of Research, Southern College of Optometry, TN 38104-2222, USA. contact@pinakin-gunvant.com
authors.forename: Pinakin
authors.initials: P
authors.lastname: Gunvant
authors.forename: Yufeng
authors.initials: Y
authors.lastname: Zheng
authors.forename: Edward A
authors.initials: EA
authors.lastname: Essock
authors.forename: Rajul S
authors.initials: RS
authors.lastname: Parikh
authors.forename: Selvaraj
authors.initials: S
authors.lastname: Prabakaran
authors.forename: Jonnadula Ganesh
authors.initials: JG
authors.lastname: Babu
authors.forename: Chandra G
authors.initials: CG
authors.lastname: Shekar
authors.forename: Ravi
authors.initials: R
authors.lastname: Thomas
mesh_terms: D003941:Diagnostic Techniques, Ophthalmological; D005583:Fourier Analysis; D005902:Glaucoma, Open-Angle / Q000175:diagnosis*; D006801:Humans; D007429:Intraocular Pressure; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D009898:Optic Disk / Q000473:pathology*; D009901:Optic Nerve Diseases / Q000175:diagnosis*; D011446:Prospective Studies; D012372:ROC Curve; D012165:Retinal Ganglion Cells / Q000473:pathology*; D041623:Tomography, Optical Coherence; D014065:Tonometry, Ocular; D058609:Visual Field Tests; D014794:Visual Fields