title: Prevalence rates and antifungal susceptibility profiles of the Candida parapsilosis species complex: results from a nationwide surveillance of candidaemia in Brazil.
abstract: The genetically heterogeneous taxon Candida parapsilosis was recently reclassified into three species: Candida parapsilosis, Candida orthopsilosis and Candida metapsilosis. The prevalences of these species among 141 bloodstream isolates tested in Brazil were 88% for C. parapsilosis, 9% for C. orthopsilosis, and 3% for C. metapsilosis. Except for three C. orthopsilosis isolates that were considered resistant to 5-flucytosine, all isolates representing the different species of this complex were susceptible to polyenes, triazoles and caspofungin.
authors.affiliation: Laboratório Especial de Micologia, Disciplina de Infectologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: S S
authors.initials: SS
authors.lastname: Gonçalves
authors.forename: C S
authors.initials: CS
authors.lastname: Amorim
authors.forename: M
authors.initials: M
authors.lastname: Nucci
authors.forename: A C B
authors.initials: AC
authors.lastname: Padovan
authors.forename: M R S
authors.initials: MR
authors.lastname: Briones
authors.forename: A S A
authors.initials: AS
authors.lastname: Melo
authors.forename: A L
authors.initials: AL
authors.lastname: Colombo
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001938:Brazil / Q000453:epidemiology; D002175:Candida / Q000145:classification / Q000187:drug effects* / Q000302:isolation & purification; D002177:Candidiasis / Q000453:epidemiology* / Q000382:microbiology; D000077336:Caspofungin; D004271:DNA, Fungal / Q000032:analysis; D025141:Drug Resistance, Fungal; D054714:Echinocandins / Q000494:pharmacology / Q000627:therapeutic use; D005437:Flucytosine / Q000494:pharmacology / Q000627:therapeutic use; D016469:Fungemia / Q000453:epidemiology* / Q000382:microbiology; D006801:Humans; D055666:Lipopeptides; D008826:Microbial Sensitivity Tests; D016533:Mycological Typing Techniques; D011090:Polyenes / Q000494:pharmacology / Q000627:therapeutic use; D011159:Population Surveillance; D015995:Prevalence; D014230:Triazoles / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000935:Antifungal Agents; D004271:DNA, Fungal; D054714:Echinocandins; D055666:Lipopeptides; D011090:Polyenes; D014230:Triazoles; D005437:Flucytosine; D000077336:Caspofungin