Hoffmann's syndrome: a case report.
This syndrome is characterized by the presence of hypothyroidism with myxoedema, muscle stiffness and pseudo hypertrophy. We describe the disorder in a 21 year old male, who got admitted with complaints of generalized weakness, cold intolerance, constipation, and hoarse voice, difficulty in walking and progressive enlargement of muscles of thighs and back with crampy pains for two years. Examination revealed mild mental retardation, enlarged tongue, dry and rough skin, enlargement of thighs and back muscles, motor weakness in flexors of hips and knees with delayed relaxation of deep tendon reflexes. Investigations revealed evidence of hypothyroidism with marked elevation of muscle enzymes. Following institution of replacement therapy with thyroxine, the patient showed marked clinical and biochemical improvements after six months, but insignificant decrease in muscle mass. In this report we review relevant literature.
Qureshi
Waseem
W
SMHS Hospital, Srinagar, Kashmir, India.
Hassan
Ghulam
G
Khan
Ghulam Qadir
GQ
Kadri
Syed Manzoor
SM
Kak
Manish
M
Ahmad
Manzoor
M
Tak
Shahid
S
Kundal
Darshan Lal
DL
Hussain
Showkat
S
Rather
Abdul Rashid
AR
Masoodi
Ibrahim
I
Sikander
Sabia
S
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