[The expression pattern and possible function of microRNA-34a in neurons].
Using Northern blotting, ISH and FISH, we demonstrated miR-34a expresses with aging in the brain of rhesus monkey and rat. Correspondingly, the same trend was found in the primary cultures of cortical neurons. Moreover, we found that induction of miR-34a led to neuronal apoptosis by targeting BCL-2. Our study suggests that miR-34a may play critical roles in neuronal development and ageing.
Qi
Yan Ting
YT
Institute of Molecular and Chemical Biology, East China Normal University, Shanghai 200062, China.
Zhao
Yu
Y
Zhang
Zhi
Z
Li
Dan
D
Gu
Ji Yi
JY
Fu
Xiao Nan
XN
Chen
Xiao Na
XN
Yuan
Chong Gang
CG
Lai
Li Hui
LH
D000375:Aging / Q000235:genetics; D000818:Animals; D017209:Apoptosis / Q000235:genetics; D002478:Cells, Cultured; D005260:Female; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D006801:Humans; D008253:Macaca mulatta / Q000235:genetics*; D035683:MicroRNAs / Q000235:genetics*; D009474:Neurons / Q000166:cytology / Q000378:metabolism*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism; D051381:Rats
D035683:MicroRNAs; D019253:Proto-Oncogene Proteins c-bcl-2