title: Nicotinic receptors, amyloid-beta, and synaptic failure in Alzheimer's disease.
abstract: Dysfunctional cholinergic transmission is thought to underlie, at least in part, memory impairment and cognitive deficits in Alzheimer's disease (AD). However, it is still unclear whether this is a consequence of the loss of cholinergic neurons and elimination of nicotinic acetycholine receptors (nAChRs) in AD brain or of a direct impact of molecular interactions of the amyloid-beta (Abeta) peptide with nAChRs, leading to dysregulation of receptor function. This review examines recent progress in our understanding of the roles of nicotinic receptors in mechanisms of synaptic plasticity, molecular interactions of Abeta with nAChRs, and how Abeta-induced dysregulation of nicotinic receptor function may underlie synaptic failure in AD.
authors.affiliation: Institute of Medical Biochemistry, Federal University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, 21944-590, Brazil.
authors.forename: Sofia
authors.initials: S
authors.lastname: Jürgensen
authors.forename: Sergio T
authors.initials: ST
authors.lastname: Ferreira
mesh_terms: D000109:Acetylcholine / Q000378:metabolism; D000544:Alzheimer Disease / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D002799:Cholinergic Fibers / Q000378:metabolism / Q000473:pathology; D006801:Humans; D009410:Nerve Degeneration / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology; D009473:Neuronal Plasticity / Q000502:physiology; D011978:Receptors, Nicotinic / Q000378:metabolism*; D013569:Synapses / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D009435:Synaptic Transmission / Q000502:physiology
chemical_list: D016229:Amyloid beta-Peptides; D011978:Receptors, Nicotinic; D000109:Acetylcholine
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