title: Hepatoprotective and antioxidant activity of two iridoids from Mussaenda 'dona aurora'.
abstract: Mussaenda 'dona aurora' (sepals) has been investigated for its hepatoprotective and antioxidant activities. The highest activity was observed in the ethyl acetate fraction. The separation of the ethyl acetate fraction gave two iridoids, sanshiside-D and lamalbide. Sanshiside-D exhibited a hepatoprotective activity greater than silimarin as was evidenced by significant reduction of ALT and AST in the serum enzyme levels.
authors.affiliation: Department of Chemistry, SASTRA University, Thanjavur, Tamilnadu, India. vidyakumbak@yahoo.co.in
authors.forename: Kandulva Sethuraman
authors.initials: KS
authors.lastname: Vidyalakshmi
authors.forename: Sulochana
authors.initials: S
authors.lastname: Nagarajan
authors.forename: Hannah Rachel
authors.initials: HR
authors.lastname: Vasanthi
authors.lastname: Venkappaya
authors.forename: Victor
authors.initials: V
authors.lastname: Rajamanickam
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology; D002252:Carbon Tetrachloride Poisoning / Q000188:drug therapy; D005260:Female; D035264:Flowers / Q000737:chemistry*; D016166:Free Radical Scavengers / Q000302:isolation & purification / Q000494:pharmacology; D039823:Iridoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology* / Q000627:therapeutic use; D008099:Liver / Q000187:drug effects / Q000473:pathology*; D008297:Male; D051379:Mice; D008958:Models, Molecular; D010936:Plant Extracts / Q000737:chemistry; D019666:Rubiaceae / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D016166:Free Radical Scavengers; D039823:Iridoids; D010936:Plant Extracts