title: Validation of the association between AGTRL1 polymorphism and coronary artery disease in the Japanese and Korean populations.
abstract: Coronary artery disease (CAD) and stroke are the major health problems in many countries because of their increasing prevalence and high mortality. It is well known that CAD and stroke are based on atherosclerosis and shared environmental and genetic risk factors. Recently, an association of a functional sequence variation -154G>A in the angiotensin receptor-like 1 (AGTRL1) with a susceptibility to stroke was reported. In this study, we investigated a total of 1479 CAD cases and 2062 controls from the Japanese and Korean populations to validate the association of AGTRL1 with CAD. However, we obtained no evidence of the association in both the Japanese (odds ratio (OR)=0.95, 95% confidence interval (CI); 0.82-1.10, P=0.47, allele count model) and Korean (OR=0.90, 95% CI; 0.77-1.05, P=0.18, allele count model) populations. In addition, there was no trend of association between the risk allele and severity of coronary atherosclerosis. These data suggested that AGTRL1 did not contribute much to the atherosclerosis of the coronary artery.
authors.affiliation: Department of Molecular Pathogenesis, Medical Research Institute, and Laboratory of Genome Diversity, Graduate School of Biomedical Science, Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Hinohara
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Nakajima
authors.forename: Taishi
authors.initials: T
authors.lastname: Sasaoka
authors.forename: Motoji
authors.initials: M
authors.lastname: Sawabe
authors.forename: Bok-Soo
authors.initials: BS
authors.lastname: Lee
authors.forename: Ji-Min
authors.initials: JM
authors.lastname: Ban
authors.forename: Jeong-Euy
authors.initials: JE
authors.lastname: Park
authors.forename: Toru
authors.initials: T
authors.lastname: Izumi
authors.forename: Akinori
authors.initials: A
authors.lastname: Kimura
mesh_terms: D000368:Aged; D000075244:Apelin Receptors; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000235:genetics*; D005260:Female; D006801:Humans; D007723:Korea; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D043562:Receptors, G-Protein-Coupled / Q000235:genetics*
chemical_list: C104575:APLNR protein, human; D000075244:Apelin Receptors; D043562:Receptors, G-Protein-Coupled