title: Plasma levels of inflammatory and thrombotic/fibrinolytic markers in acute ischemic strokes: relationship with TOAST subtype, outcome and infarct site.
abstract: BACKGROUND
  The aim of our study was to evaluate in patients with acute ischemic stroke the relationship between immuno-inflammatory variables, clinical outcome and infarct site.
  
  
  METHODS
  We evaluated plasma levels of IL-1beta, TNF-alpha, IL-6 and IL-10, E-selectin, P-selectin, sICAM-1 ,sVCAM-1 vWF, TPA and PAI-1.
  
  
  RESULTS
  Patients with cardioembolic subtype showed significantly higher median plasma levels of TNF-alpha, IL-6, IL-1beta whereas the lacunar subtype showed significantly lower median plasma levels of TNF-alpha, IL-6 and IL-1beta.
  
  
  CONCLUSIONS
  A significant association was noted between the severity of neurological deficit at admission, the diagnostic subtype and some inflammatory variables.
authors.affiliation: Dipartimento Biomedico di Medicina Interna e Specialistica, Università degli Studi di Palermo, P.zza delle Cliniche, Palermo, Italy. brunotutto@unipa.it
authors.forename: Antonino
authors.initials: A
authors.lastname: Tuttolomondo
authors.forename: Riccardo
authors.initials: R
authors.lastname: Di Sciacca
authors.forename: Domenico
authors.initials: D
authors.lastname: Di Raimondo
authors.forename: Antonia
authors.initials: A
authors.lastname: Serio
authors.forename: Gisella
authors.initials: G
authors.lastname: D'Aguanno
authors.forename: Sergio
authors.initials: S
authors.lastname: La Placa
authors.forename: Rosaria
authors.initials: R
authors.lastname: Pecoraro
authors.forename: Valentina
authors.initials: V
authors.lastname: Arnao
authors.forename: Luciana
authors.initials: L
authors.lastname: Marino
authors.forename: Serena
authors.initials: S
authors.lastname: Monaco
authors.forename: Eraldo
authors.initials: E
authors.lastname: Natalè
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Licata
authors.forename: Antonio
authors.initials: A
authors.lastname: Pinto
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D002545:Brain Ischemia / Q000097:blood* / Q000145:classification* / Q000473:pathology; D002544:Cerebral Infarction / Q000097:blood / Q000145:classification / Q000473:pathology; D005260:Female; D005342:Fibrinolysis / Q000502:physiology*; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D020767:Intracranial Thrombosis / Q000097:blood / Q000145:classification / Q000473:pathology; D008297:Male; D008875:Middle Aged; D020521:Stroke / Q000097:blood* / Q000145:classification* / Q000473:pathology
chemical_list: D015415:Biomarkers; D018836:Inflammation Mediators