Clinical evaluation of a new collagen matrix (Mucograft prototype) to enhance the width of keratinized tissue in patients with fixed prosthetic restorations: a randomized prospective clinical trial.
OBJECTIVE
The aim of this study was to test a new collagen matrix (CM) aimed to increase keratinized gingiva/mucosa when compared with the free connective tissue graft (CTG).


METHODS
This randomized longitudinal parallel controlled clinical trial studied 20 patients with at least one location with minimal keratinized tissue (<or=1 mm).


METHODS
The 6-month width of keratinized tissue. As secondary outcomes, the aesthetic outlook, the maintenance of periodontal health and the patient morbidity were assessed pre-operatively at 1, 3 and 6 months.


RESULTS
At 6 months, the CTG attained a mean width of keratinized tissue of 2.6 (0.9) mm, while the CM was 2.5 (0.9) mm, these differences being insignificant. In both groups, there was a marked contraction (60% and 67%, respectively) although the periodontal parameters were not affected. The CM group had a significantly lower patient morbidity (pain and medication intake) as well as reduced surgery time.


CONCLUSIONS
These results prove that this new CM was as effective and predictable as the CTG for attaining a band of keratinized tissue, but its use was associated with a significantly lower patient morbidity.
Sanz
Mariano
M
Faculty of Odontology, University Complutense of Madrid, Madrid, Spain. marianosanz@odon.ucm.es
Lorenzo
Ramón
R
Aranda
Juan J
JJ
Martin
Conchita
C
Orsini
Marco
M
D000328:Adult; D000368:Aged; D000700:Analgesics / Q000627:therapeutic use; D001672:Biocompatible Materials / Q000627:therapeutic use*; D003094:Collagen / Q000627:therapeutic use*; D003238:Connective Tissue / Q000637:transplantation; D019094:Dental Prosthesis, Implant-Supported; D003830:Denture, Partial, Fixed; D004955:Esthetics, Dental; D005260:Female; D005500:Follow-Up Studies; D005881:Gingiva / Q000473:pathology / Q000637:transplantation; D005889:Gingival Recession / Q000601:surgery; D005893:Gingivoplasty / Q000379:methods*; D006801:Humans; D007633:Keratins; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000601:surgery; D010149:Postoperative Pain / Q000209:etiology; D017622:Periodontal Attachment Loss / Q000601:surgery; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000601:surgery; D011446:Prospective Studies; D013524:Surgical Flaps; D013997:Time Factors; D016896:Treatment Outcome
D000700:Analgesics; D001672:Biocompatible Materials; D007633:Keratins; D003094:Collagen