DNA polymerases at the eukaryotic fork-20 years later.
Function of the eukaryotic genome depends on efficient and accurate replication of anti-parallel DNA strands. Eukaryotic DNA polymerases have different properties adapted to perform a wide spectrum of DNA transactions. Here we focus on major players in the bulk replication, DNA polymerases of the B-family. We review the organization of the replication fork in eukaryotes in a historical perspective, analyze contemporary models and propose a new integrative model of the fork.
Pavlov
Youri I
YI
Eppley Institute for Research in Cancer, University of Nebraska Medical Center, Omaha, NE 68198-6805, USA. ypavlov@unmc.edu
Shcherbakova
Polina V
PV
D004261:DNA Replication; D004259:DNA-Directed DNA Polymerase / Q000737:chemistry / Q000378:metabolism*; D005057:Eukaryotic Cells; D008957:Models, Genetic
D004259:DNA-Directed DNA Polymerase
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