title: Bakkenolides from Petasites tatewakianus.
abstract: A new bakkenolide and a known one were isolated from Petasites tatewakianus. The structure of the new compound was elucidated on the basis of spectroscopic methods including IR, EIMS, HRESIMS, 1D and 2D NMR, and the known compound was established by single crystal X-ray structural analysis. The in vitro cytotoxic activity of these two compounds against cultured human cervical carcinoma (HeLa), human breast cancer (MCF-7) and murine Lewis lung carcinoma (LLC) cell lines was also evaluated.
authors.affiliation: Marine College, Shandong University at Weihai, Weihai, PR China. wdxie@sdu.edu.cn
authors.forename: Xie Wei
authors.initials: XW
authors.lastname: Dong
authors.forename: Rui Juan
authors.initials: RJ
authors.lastname: Li
authors.forename: Xue
authors.initials: X
authors.lastname: Gao
authors.forename: Kyung Ho
authors.initials: KH
authors.lastname: Row
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000627:therapeutic use; D002277:Carcinoma / Q000188:drug therapy*; D005260:Female; D006367:HeLa Cells; D006801:Humans; D051379:Mice; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy*; D036901:Petasites / Q000737:chemistry*; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification* / Q000627:therapeutic use; D027343:Rhizome; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000627:therapeutic use
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D012717:Sesquiterpenes; C551157:bakkenolide B; C551156:petatewalide A