title: Processing umami and other tastes in mammalian taste buds.
abstract: Neuroscientists are now coming to appreciate that a significant degree of information processing occurs in the peripheral sensory organs of taste prior to signals propagating to the brain. Gustatory stimulation causes taste bud cells to secrete neurotransmitters that act on adjacent taste bud cells (paracrine transmitters) as well as on primary sensory afferent fibers (neurocrine transmitters). Paracrine transmission, representing cell-cell communication within the taste bud, has the potential to shape the final signal output that taste buds transmit to the brain. The following paragraphs summarize current thinking about how taste signals generally, and umami taste in particular, are processed in taste buds.
authors.affiliation: Department of Physiology and Biophysics, and Program in Neuroscience, Miller School of Medicine, University of Miami, Miami, Florida 33136, USA. sroper@med.miami.edu
authors.forename: Stephen D
authors.initials: SD
authors.lastname: Roper
authors.forename: Nirupa
authors.initials: N
authors.lastname: Chaudhari
mesh_terms: D000818:Animals; D008954:Models, Biological; D009435:Synaptic Transmission; D013649:Taste; D013650:Taste Buds / Q000166:cytology / Q000502:physiology*
references.citation: Eur J Neurosci. 2000 Sep;12(9):3163-71
references.pmid: 10998100
references.citation: Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6436-41
references.pmid: 17389364
references.citation: J Neurosci. 2000 Nov 1;20(21):7978-85
references.pmid: 11050118
references.citation: J Neurosci. 2006 Apr 12;26(15):3971-80
references.pmid: 16611813
references.citation: BMC Biol. 2006 Mar 30;4:7
references.pmid: 16573824
references.citation: Adv Anat Embryol Cell Biol. 1978;55(1):3-94
references.pmid: 358774
references.citation: J Neurosci. 1994 Jun;14(6):3791-804
references.pmid: 8207488
references.citation: J Comp Neurol. 2004 Jan 12;468(3):311-21
references.pmid: 14681927
references.citation: J Neurosci. 2003 Apr 1;23(7):2608-17
references.pmid: 12684446
references.citation: J Comp Neurol. 2001 Nov 5;440(1):97-108
references.pmid: 11745610
references.citation: J Physiol. 2008 Jun 15;586(12):2903-12
references.pmid: 18420705
references.citation: Chem Senses. 1996 Jun;21(3):353-65
references.pmid: 8670715
references.citation: Annu Rev Neurosci. 1989;12:329-53
references.pmid: 2648951
references.citation: J Neurosci. 2005 Jan 26;25(4):843-7
references.pmid: 15673664
references.citation: J Comp Neurol. 2007 Nov 20;505(3):302-13
references.pmid: 17879273
references.citation: Zh Evol Biokhim Fiziol. 1983 Jan-Feb;19(1):62-7
references.pmid: 6601342
references.citation: Am J Physiol Regul Integr Comp Physiol. 2004 Apr;286(4):R649-58
references.pmid: 14715493
references.citation: EMBO J. 2007 Feb 7;26(3):657-67
references.pmid: 17235286
references.citation: BMC Neurosci. 2008 Jan 02;9:1
references.pmid: 18171468
references.citation: J Neurosci. 2008 Dec 3;28(49):13088-93
references.pmid: 19052199
references.citation: J Neurosci. 2007 Oct 3;27(40):10840-8
references.pmid: 17913917
references.citation: Science. 2005 Dec 2;310(5753):1495-9
references.pmid: 16322458
references.citation: J Comp Neurol. 2006 Jul 1;497(1):1-12
references.pmid: 16680780
references.citation: J Neurophysiol. 1992 May;67(5):1316-24
references.pmid: 1597715