title: Regional dissemination of KPC-producing Klebsiella pneumoniae.
abstract: Production of a Klebsiella pneumoniae carbapenemase (KPC) is the most common mechanism of carbapenem resistance in the United States; however, until now, KPC-producing isolates have not been found in western Michigan. Molecular typing of two KPC-producing K. pneumoniae isolates from Michigan showed their similarity to other Midwestern isolates. They were also unrelated to the dominant sequence type observed throughout the United States, multilocus sequence type 258. This could represent regional dissemination of another KPC-producing K. pneumoniae strain.
authors.affiliation: Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. bkitchel@cdc.gov
authors.forename: Brandon
authors.initials: B
authors.lastname: Kitchel
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Sundin
authors.forename: Jean B
authors.initials: JB
authors.lastname: Patel
mesh_terms: D001426:Bacterial Proteins / Q000378:metabolism*; D015780:Carbapenems / Q000494:pharmacology; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000201:enzymology / Q000502:physiology*; D008824:Michigan; D014481:United States; D001618:beta-Lactamases / Q000378:metabolism*
chemical_list: D001426:Bacterial Proteins; D015780:Carbapenems; D001618:beta-Lactamases; C063912:carbapenemase
references.citation: Antimicrob Agents Chemother. 2009 Aug;53(8):3365-70
references.pmid: 19506063
references.citation: Antimicrob Agents Chemother. 2007 Apr;51(4):1553-5
references.pmid: 17261621
references.citation: Clin Infect Dis. 2004 Jul 1;39(1):55-60
references.pmid: 15206053
references.citation: Arch Intern Med. 2005 Jun 27;165(12):1430-5
references.pmid: 15983294
references.citation: J Clin Microbiol. 2005 Aug;43(8):4178-82
references.pmid: 16081970
references.citation: J Clin Microbiol. 2008 Jun;46(6):2066-9
references.pmid: 18385437
references.citation: Antimicrob Agents Chemother. 2008 Jun;52(6):2014-8
references.pmid: 18332176
references.citation: Antimicrob Agents Chemother. 2005 Oct;49(10):4423-4
references.pmid: 16189140
references.citation: Antimicrob Agents Chemother. 2008 Apr;52(4):1257-63
references.pmid: 18227185
references.citation: J Antimicrob Chemother. 2007 Jul;60(1):78-82
references.pmid: 17490999
references.citation: J Antimicrob Chemother. 2009 Apr;63(4):654-8
references.pmid: 19218573
references.citation: Foodborne Pathog Dis. 2006 Spring;3(1):20-31
references.pmid: 16602976
references.citation: J Antimicrob Chemother. 2008 Dec;62(6):1261-4
references.pmid: 18812425
references.citation: MMWR Morb Mortal Wkly Rep. 2009 Mar 20;58(10):256-60
references.pmid: 19300408
references.citation: J Antimicrob Chemother. 2007 Sep;60(3):470-82
references.pmid: 17595289