title: Navigating the cell: UNC-53 and the navigators, a family of cytoskeletal regulators with multiple roles in cell migration, outgrowth and trafficking.
abstract: Changes in cell shape are associated with a variety of processes including cell migration, axon outgrowth, cell division and vesicle trafficking. C. elegans UNC-53 and its vertebrate homologs, the Navigators, are required for the migration of cells and the outgrowth of neuronal processes. The identification of novel molecular interactions and live imaging studies have revealed that UNC-53/NAVs are signal transducers associated with actin filaments, microtubules and intermediate filaments. In addition to modulating cytoskeletal dynamics at the leading edge of migrating or outgrowing cells, both UNC-53 and the navigators are expressed in adult cells, conspicuously those with specialized roles in endocytosis or secretion. Collectively, these results suggest that UNC-53/NAVs may be a central regulator of cytoskeletal dynamics, responsible for integrating signaling cues to multiple components of the cytoskeleton to coordinate rearrangement during cell outgrowth or trafficking.
authors.affiliation: Department of Biology, Trinity Western University, Langley, BC, Canada. stringha@twu.ca
authors.forename: Eve G
authors.initials: EG
authors.lastname: Stringham
authors.forename: Kristopher L
authors.initials: KL
authors.lastname: Schmidt
mesh_terms: D000818:Animals; D001692:Biological Transport / Q000502:physiology; D029742:Caenorhabditis elegans Proteins / Q000502:physiology*; D049108:Cell Enlargement; D002465:Cell Movement / Q000502:physiology*; D003599:Cytoskeleton / Q000378:metabolism*; D006801:Humans; D008840:Microfilament Proteins / Q000502:physiology*
chemical_list: D029742:Caenorhabditis elegans Proteins; D008840:Microfilament Proteins; C465016:UNC-53 protein, C elegans
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