Recent findings on the pathogenesis of bronchial asthma. Part II. The role of hormonal predisposition, environmental influences and conditioning leading to bronchial asthma.
In this second part of the review on the pathogenesis of asthma the hormonal factors and adverse external events are shortly reviewed which skew the balance of Th1 vs. Th2 CD4+ lymphocytes towards the latter ones and this way increase the probability of atopic diseases. Among other the role of transplacental priming, insulin, insulin-like and other growth factors, lack of the usual microbial infections in the early childhood (the so-called hygiene hypothesis), gender, diminished testosterone production, gastroesophageal reflux, adverse effects during pregnancy are discussed. A separate chapter deals with the role of central nervous system in the etiology and finally the most common allergizing and airway tissue damaging agents are listed in tabulated form.
Székely
József Iván
JI
Human Physiology Department, Semmelweis University, Tuzoltó u. 37-47, Budapest, Hungary.
Pataki
A
A
D000485:Allergens / Q000009:adverse effects*; D000818:Animals; D001249:Asthma / Q000209:etiology* / Q000276:immunology / Q000378:metabolism / Q000503:physiopathology; D002490:Central Nervous System / Q000503:physiopathology; D015897:Comorbidity; D004777:Environment; D005260:Female; D006728:Hormones / Q000378:metabolism*; D006801:Humans; D008297:Male; D011247:Pregnancy; D018570:Risk Assessment; D012307:Risk Factors; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology
D000485:Allergens; D006728:Hormones