title: [Modulatory effect of isoniazid and rifampicin in vitro on cytokine secretion in pulmonary tuberculosis].
abstract: The effects of isoniazid and rifampicin on the peripheral mononuclear production of IL-2, IL-12, IL-10, IFN-gamma, and TGF-beta were evaluated in patients with infiltrative pulmonary tuberculosis. Irrespective of the susceptibility of the causative agent to the essential antituberculous drugs, rifampicin was ascertained to initiate increased IL-2 secretion and to reduce the generation of IL-12, IFN-gamma and TGF-beta. Isoniazid suppressed the mononuclear leukocytic production of IFN-gamma in drug-sensitive pulmonary tuberculosis, and conversely, stimulated it in the drug-resistant type. Rifampicin showed a more significant negative effect on mononuclear cytokine-producing activity. In drug-resistant pulmonary tuberculosis, the imbalance of spontaneous, protein- and drug-induced mononuclear secretion of cytokines was established to be more pronounced than in drug-sensitive tuberculosis.
authors.forename: V A
authors.initials: VA
authors.lastname: Serebriakova
authors.forename: O A
authors.initials: OA
authors.lastname: Vasil'eva
authors.forename: O I
authors.initials: OI
authors.lastname: Urazova
authors.forename: V V
authors.initials: VV
authors.lastname: Novitskiĭ
authors.forename: O V
authors.initials: OV
authors.lastname: Voronkova
authors.forename: A K
authors.initials: AK
authors.lastname: Strelis
authors.forename: T E
authors.initials: TE
authors.lastname: Budkina
authors.forename: R R
authors.initials: RR
authors.lastname: Khasanova
authors.forename: I O
authors.initials: IO
authors.lastname: Naslednikova
authors.forename: E G
authors.initials: EG
authors.lastname: Churina
authors.forename: A E
authors.initials: AE
authors.lastname: Kolosova
mesh_terms: D000293:Adolescent; D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use; D016207:Cytokines / Q000378:metabolism*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007538:Isoniazid / Q000627:therapeutic use*; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012293:Rifampin / Q000627:therapeutic use*; D014397:Tuberculosis, Pulmonary / Q000097:blood* / Q000188:drug therapy; D055815:Young Adult
chemical_list: D000995:Antitubercular Agents; D016207:Cytokines; D007538:Isoniazid; D012293:Rifampin