Hydroperoxy-cycloartane triterpenoids from the leaves of Markhamia lutea, a plant ingested by wild chimpanzees.
In the framework of the phytochemical investigation of plant species eaten by wild chimpanzees in their natural environment in Uganda, leaf samples of Markhamia lutea were selected and collected. The crude ethyl acetate extract of M. lutea leaves exhibited significant in vitro anti-parasitic activity and low cytotoxicity against MRC5 and KB cells. Fractionation of this extract led to six cycloartane triterpenoids, musambins A-C and their 3-O-xyloside derivatives musambiosides A-C. The structures were elucidated on the basis of spectral studies including mass spectroscopy and extensive 2D NMR. Most of the compounds exhibited mild anti-leishmanial and anti-trypanosomal activities.
Lacroix
Damien
D
Molécules de Communication et Adaptation des Micro-organismes, Unité Associée au CNRS, Muséum National d'Histoire Naturelle, 57 Rue Cuvier, 75005 Paris, France.
Prado
Soizic
S
Deville
Alexandre
A
Krief
Sabrina
S
Dumontet
Vincent
V
Kasenene
John
J
Mouray
Elisabeth
E
Bories
Christian
C
Bodo
Bernard
B
D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000494:pharmacology; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D007891:Leishmania / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D019684:Magnoliopsida / Q000737:chemistry*; D015394:Molecular Structure; D002679:Pan troglodytes; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects; D014315:Triterpenes / Q000737:chemistry / Q000494:pharmacology*; D014344:Trypanocidal Agents / Q000737:chemistry / Q000494:pharmacology; D014349:Trypanosoma cruzi / Q000187:drug effects
D000962:Antimalarials; D000981:Antiprotozoal Agents; D010936:Plant Extracts; D014315:Triterpenes; D014344:Trypanocidal Agents; C085352:cycloartane