Involvement of glucose-6-phosphate dehydrogenase in reduced glutathione maintenance and hydrogen peroxide signal under salt stress.
Cellular redox homeostasis is essential for plant growth, development as well as for the resistance to biotic and abiotic stresses, which is governed by the complex network of prooxidant and antioxidant systems. Recently, new evidence has been published that NADPH, produced by glucose-6-phosephate dehydrogenase enzyme (G6PDH), not only acted as the reducing potential for the output of reduced glutathione (GSH), but was involved in the activity of plasma membrane (PM) NADPH oxidase under salt stress, which resulted in hydrogen peroxide (H(2)O(2)) accumulation. H(2)O(2) acts as a signal in regulating G6PDH activity and expression, and the activities of the enzymes in the glutathione cycle as well, through which the ability of GSH regeneration was increased under salt stress. Thus, G6PDH plays a critical role in maintaining cellular GSH levels under long-term salt stress. In this addendum, a hypothetical model for the roles of G6PDH in modulating the intracellular redox homeostasis under salt stress is presented.
Wang
Xiaomin
X
School of Life Sciences; Lanzhou University; Lanzhou, P.R. China.
Ma
Yuanyuan
Y
Huang
Chenghong
C
Li
Jisheng
J
Wan
Qi
Q
Bi
Yurong
Y
Plant Cell Physiol. 2007 Mar;48(3):511-22
17289795
Biochem J. 1997 May 1;323 ( Pt 3):801-6
9169615
J Biol Chem. 1999 Jan 29;274(5):2750-7
9915806
Annu Rev Plant Physiol Plant Mol Biol. 2000 Jun;51:463-499
15012199
Plant Signal Behav. 2007 Nov;2(6):473-4
19704588
EMBO J. 1995 Nov 1;14(21):5209-15
7489710
Plant Cell. 2005 Jul;17(7):1866-75
15987996
Plant Cell Environ. 2007 Jul;30(7):775-85
17547650
Annu Rev Plant Physiol Plant Mol Biol. 1998 Jun;49:249-279
15012235
FASEB J. 1994 Feb;8(2):174-81
8119488
Plant Cell. 1997 Nov;9(11):2077-2091
12237354