The peptidylglycine alpha-amidating monooxygenase (PAM): a novel prodrug strategy for amidoximes and N-hydroxyguanidines?
Schade
Dennis
D
Department of Pharmaceutical and Medicinal Chemistry, Pharmaceutical Institute, Gutenbergstrasse 76, 24118 Kiel (Germany).
Kotthaus
Joscha
J
Hungeling
Helen
H
Kotthaus
Jürke
J
Clement
Bernd
B
D000818:Animals; D006146:Guanidines / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D006898:Hydroxylamines; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D009097:Multienzyme Complexes / Q000378:metabolism*; D010091:Oximes / Q000737:chemistry / Q000378:metabolism*; D011355:Prodrugs / Q000737:chemistry / Q000378:metabolism*
D006146:Guanidines; D006898:Hydroxylamines; D009097:Multienzyme Complexes; D010091:Oximes; D011355:Prodrugs; C029604:hydroxyguanidine; D006899:Mixed Function Oxygenases; C035189:peptidylglycine monooxygenase