Can the protein occupancy landscape show the topologically isolated chromosomal domains in the E. coli genome?: An exciting prospect.
In a recent issue of Molecular Cell, Vora et al. (2009) introduce an in vivo protein occupancy display (IPOD) technology and propose that the domains extensively occupied by proteins with inactive transcription in bacteria are mainly topologically isolated chromosomal domains.
Cho
Byung-Kwan
BK
Department of Bioengineering, University of California, San Diego, La Jolla, 92093, USA.
Palsson
Bernhard Ø
BØ
D001665:Binding Sites; D047369:Chromatin Immunoprecipitation; D002876:Chromosomes, Bacterial / Q000737:chemistry / Q000378:metabolism*; D018983:DNA Footprinting; D004926:Escherichia coli / Q000235:genetics* / Q000378:metabolism; D029968:Escherichia coli Proteins / Q000235:genetics / Q000378:metabolism*; D016680:Genome, Bacterial
D029968:Escherichia coli Proteins