title: Limb sparing treatment of bleeding melanoma recurrence by electrochemotherapy.
abstract: OBJECTIVE
  Electrochemotherapy is an effective local treatment for tumors that combines administration of a chemotherapeutic drug with the subsequent application of electric pulses to the tumor. In addition, it was also found to have a vascular-disrupting effect. We report a case of limb-sparing treatment of bleeding melanoma recurrence by electrochemotherapy
  
  
  METHODS
  After intravenous application of bleomycin (15,000 IU/m2), 15 runs of electric pulses were applied by hexagonal needle electrodes (1.7 cm in diameter) in the center of the bleeding melanoma recurrence, and an additional 10 runs of electric pulses were delivered via plate electrodes (8 mm) on the rim of the tumor.
  
  
  RESULTS
  Immediately after the administration of electric pulses, the bleeding stopped and did not recur. Crust formation was observed and the lesion decreased in size in a matter of weeks.
  
  
  CONCLUSIONS
  We conclude that electrochemotherapy should be considered as a treatment option when dealing with bleeding melanoma recurrences as well as a limb-preserving treatment.
authors.affiliation: Institute of Oncology Ljubljana, Zaloska 2, Ljubljana, Slovenia.
authors.forename: Marko
authors.initials: M
authors.lastname: Snoj
authors.forename: Maja
authors.initials: M
authors.lastname: Cemazar
authors.forename: Tinkara
authors.initials: T
authors.lastname: Srnovrsnik
authors.forename: Snezna Paulin
authors.initials: SP
authors.lastname: Kosir
authors.forename: Gregor
authors.initials: G
authors.lastname: Sersa
mesh_terms: D000369:Aged, 80 and over; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage*; D001761:Bleomycin / Q000008:administration & dosage*; D053672:Electrochemotherapy; D017809:Fatal Outcome; D006470:Hemorrhage / Q000209:etiology*; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary; D008297:Male; D008545:Melanoma / Q000150:complications / Q000188:drug therapy* / Q000532:radiotherapy / Q000556:secondary; D010166:Palliative Care / Q000379:methods; D012878:Skin Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy
chemical_list: D000903:Antibiotics, Antineoplastic; D001761:Bleomycin