Rhodium-catalyzed highly enantioselective direct intermolecular hydroacylation of 1,1-disubstituted alkenes with unfunctionalized aldehydes.
We have established that a cationic rhodium(I)/(R,R)-QuinoxP* complex catalyzes the highly enantioselective direct intermolecular hydroacylation of alpha-substituted acrylamides with unfunctionalized aliphatic aldehydes to yield the corresponding gamma-ketoamides in high yields with excellent ee values.
Shibata
Yu
Y
Department of Applied Chemistry, Graduate School of Engineering, Tokyo University of Agriculture and Technology, Koganei, Tokyo 184-8588, Japan.
Tanaka
Ken
K