title: Phototropin receptor kinase activation by blue light.
abstract: Phototropins (phot1 and phot2) are blue light-activated serine/threonine protein kinases that function to mediate a variety of adaptive processes that serve to optimize the photosynthetic efficiency of plants and thereby promote their growth. Light sensing by the phototropins is mediated by a repeated motif located within the N-terminal region of the protein designated the LOV domain. Although phototropins possess two LOV photosensors (LOV1 and LOV2), recent biophysical and structure-function analyses clearly indicate that the LOV2 domain plays a predominant role in regulating phototropin kinase activity owing to specific protein changes that occur in response to LOV2 photoexcitation. In particular, the central beta-sheet scaffold plays a role in propagating the photochemical signal generated from within LOV2 to protein changes at the surface that are necessary for kinase activation.
authors.affiliation: Plant Science Group; Division of Biochemistry and Molecular Biology; Institute of Biomedical and Life Sciences; University of Glasgow; Glasgow, Scotland UK.
authors.forename: Matthew A
authors.initials: MA
authors.lastname: Jones
authors.forename: John M
authors.initials: JM
authors.lastname: Christie
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