title: High oxidative stress is correlated with frailty in elderly chinese.
abstract: OBJECTIVE
  To evaluate the relationship between oxidative stress and frailty in elderly people.
  
  
  METHODS
  Cross-sectional study.
  
  
  METHODS
  Community and hospital-based outpatient clinic.
  
  
  METHODS
  Ninety participants aged 65 and older.
  
  
  METHODS
  Frailty status was determined according to the presence of weak handgrip strength, weight loss, slow walking speed, exhaustion, and low activity level and was classified as frail (> or =3 criteria), prefrail (1 or 2 criteria), or robust (0 criteria). An oxidative stress marker (serum 8-hydroxy-2'-deoxyguanosine, 8-OHdG), metabolic markers (body mass index, waist-hip ratio, serum lipids, glucose, and albumin), an inflammatory marker (serum high-sensitivity C-reactive protein, hs-CRP), demographic information, and comorbidities (diabetes mellitus, hypertension, congestive heart failure, osteoarthritis, overweight or obesity, impaired fasting plasma glucose, renal insufficiency, and depression) were assessed.
  
  
  RESULTS
  Of the 90 participants, 21 (23.3%) were frail, 56 (62.2%) were prefrail, and 13 (14.4%) were robust. Frail subjects had higher median (range) serum 8-OHdG (2.5 ng/mL (1.5-6.2 ng/mL) vs 2.3 ng/mL (0.5-8.1 ng/mL) and 1.0 ng/mL (0.5-5.3 ng/mL)) and serum hs-CRP (2.5 mg/L (0.3-32.1 mg/L) vs 1.8 mg/L (0.3-50.5 mg/L) and 1.7 mg/L (0.3-4.0 mg/L)) levels, lower mean+/-standard deviation serum albumin levels (4.1+/-0.4 g/dL vs 4.4+/-0.4 g/dL and 4.6+/-0.2 g/dL) and higher mean waist-hip ratios (0.96+/-0.11 vs 0.91+/-0.07 and 0.89+/-0.05)) than prefrail and robust subjects, respectively (P<.05 for all). In multivariable regression analysis, high serum 8-OHdG level was still significantly associated with frailty after adjusting for age, smoking status, comorbidities, waist-hip ratio, serum albumin level, and hs-CRP level.
  
  
  CONCLUSIONS
  High oxidative stress, characterized by high serum 8-OHdG level, was independently associated with frailty in the selected sample of elderly Chinese.
authors.affiliation: Department of Internal Medicine, College of Medicine, National Cheng Kung University, Tainan 70403, Taiwan.
authors.forename: I-Chien
authors.initials: IC
authors.lastname: Wu
authors.forename: Shu-Chu
authors.initials: SC
authors.lastname: Shiesh
authors.forename: Po-Hsiu
authors.initials: PH
authors.lastname: Kuo
authors.forename: Xi-Zhang
authors.initials: XZ
authors.lastname: Lin
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D003430:Cross-Sectional Studies; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000097:blood; D005260:Female; D016330:Frail Elderly; D006306:Health Surveys; D006801:Humans; D008297:Male; D018384:Oxidative Stress / Q000502:physiology*; D012016:Reference Values; D013624:Taiwan; D049629:Waist-Hip Ratio
chemical_list: D015415:Biomarkers; D000080242:8-Hydroxy-2'-Deoxyguanosine; D003849:Deoxyguanosine