title: Pharmacokinetic optimization of immunosuppressive therapy in thoracic transplantation: part II.
abstract: Part I of this article, which appeared in the previous issue of the Journal, reviewed calcineurin inhibitors--ciclosporin and tacrolimus. In part II, we review the pharmacokinetics and therapeutic drug monitoring of mycophenolate and mammalian target of rapamycin inhibitors--sirolimus and everolimus--in thoracic transplantation, and we provide an overall discussion and suggest various areas for future study.
authors.affiliation: INSERM Unit 850, CHU Limoges, University of Limoges, Limoges, France.
authors.forename: Caroline
authors.initials: C
authors.lastname: Monchaud
authors.forename: Pierre
authors.initials: P
authors.lastname: Marquet
mesh_terms: D000818:Animals; D016027:Heart Transplantation / Q000379:methods* / Q000502:physiology / Q000639:trends; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods* / Q000639:trends; D007166:Immunosuppressive Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D016040:Lung Transplantation / Q000379:methods* / Q000502:physiology / Q000639:trends; D019616:Thoracic Surgical Procedures / Q000379:methods / Q000639:trends; D014018:Tissue Distribution / Q000187:drug effects / Q000502:physiology
chemical_list: D007166:Immunosuppressive Agents
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