title: First isolation of Clostridium difficile PCR ribotype 027 from a patient with severe persistent diarrhoea in Hungary.
abstract: A recent Supplement to Clinical Microbiology and Infection entitled 'Infection control measures to limit the spread of C. difficile' pointed out that the incidence of C. difficile-associated diarrhoea (CDAD) has been increasing worldwide, and stressed the importance of research in the fields of epidemiology and infection control [1]. Since 2003, one of the main causes of the increasing prevalence of CDAD has been claimed to be the emergence of PCR ribotype 027/NAP1, which has caused epidemics in North America, the UK, the Netherlands, Belgium and France. The presence of PCR ribotype 027 in Austria, Japan, Ireland, Germany and Switzerland has also been reported recently [2,3]. The majority of publications have emphasized that the presence of this strain is usually associated with more severe symptoms and signs than those associated with the other more common toxin-positive strains [4,5]. Whereas PCR ribotype 027 was present in the population earlier, the majority of the historic strains were fluoroquinolone sensitive [6]. The overuse of antibiotics such as fluoroquinolones may lead to the selection and emergence of resistant strains, and may contribute to the spread of PCR ribotype 027, which is usually resistant to erythromycin. Here, the Eastern European spread of C. difficile PCR ribotype 027 is reported.
authors.forename: G
authors.initials: G
authors.lastname: Terhes
authors.forename: E
authors.initials: E
authors.lastname: Urbán
authors.forename: M
authors.initials: M
authors.lastname: Konkoly-Thege
authors.forename: E
authors.initials: E
authors.lastname: Székely
authors.forename: J S
authors.initials: JS
authors.lastname: Brazier
authors.forename: E J
authors.initials: EJ
authors.lastname: Kuijper
authors.forename: E
authors.initials: E
authors.lastname: Nagy
mesh_terms: D016360:Clostridioides difficile / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D003967:Diarrhea / Q000382:microbiology*; D006801:Humans; D006814:Hungary; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction / Q000379:methods*; D021521:Ribotyping