title: Fatal lactic acidosis precipitated by nifedipine in a patient treated with disulfiram and antiretrovirals.
abstract: A 43 year old man with HIV and HCV infection and liver cirrhosis developed fatal lactic acidosis within five days from starting nifedipine for arterial hypertension. Multiple drug interactions, current and accumulated drug toxicities and the reduced liver function, might in combination have led to the acute lactic acidosis.
authors.affiliation: Division of Infectious Diseases, Ospedale Generale, Bolzano 39100, Italy. molosw@hotmail.com
authors.forename: Oswald
authors.initials: O
authors.lastname: Moling
authors.forename: Giovanni
authors.initials: G
authors.lastname: Rimenti
authors.forename: Raffaele
authors.initials: R
authors.lastname: Pristerà
authors.forename: Claudio
authors.initials: C
authors.lastname: Vedovelli
authors.forename: Leonardo
authors.initials: L
authors.lastname: Pagani
authors.forename: Greta
authors.initials: G
authors.lastname: Spoladore
authors.forename: Peter
authors.initials: P
authors.lastname: Mian
mesh_terms: D000140:Acidosis, Lactic / Q000139:chemically induced* / Q000378:metabolism; D000328:Adult; D000427:Alcohol Deterrents / Q000009:adverse effects* / Q000493:pharmacokinetics; D000437:Alcoholism / Q000150:complications / Q000188:drug therapy; D044966:Anti-Retroviral Agents / Q000009:adverse effects* / Q000493:pharmacokinetics; D000959:Antihypertensive Agents / Q000009:adverse effects* / Q000493:pharmacokinetics; D023241:Antiretroviral Therapy, Highly Active; D004221:Disulfiram / Q000009:adverse effects* / Q000493:pharmacokinetics; D004347:Drug Interactions; D017809:Fatal Outcome; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy*; D006526:Hepatitis C / Q000150:complications*; D006801:Humans; D006973:Hypertension / Q000139:chemically induced / Q000188:drug therapy*; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008103:Liver Cirrhosis / Q000209:etiology; D008297:Male; D009102:Multiple Organ Failure / Q000139:chemically induced; D009543:Nifedipine / Q000009:adverse effects* / Q000493:pharmacokinetics
chemical_list: D000427:Alcohol Deterrents; D044966:Anti-Retroviral Agents; D000959:Antihypertensive Agents; D009543:Nifedipine; D004221:Disulfiram