title: Nanoshell-based substrates for surface enhanced spectroscopic detection of biomolecules.
abstract: Nanoshells are optically tunable core-shell nanostructures with demonstrated uses in surface enhanced spectroscopies. Based on their ability to support surface plasmons, which give rise to strongly enhanced electromagnetic fields at their surface, nanoshells provide simple, scalable, high-quality substrates. In this article, we outline the development and use of nanoshell-based substrates for direct, spectroscopic detection of biomolecules. Recent advances in the use of these nanostructures lead to improved spectroscopic quality, selectivity, and reproducibility.
authors.affiliation: Department of Chemistry, Rice University, P.O. Box 1892, Houston, Texas 77251-1892, USA.
authors.forename: Carly S
authors.initials: CS
authors.lastname: Levin
authors.forename: Janardan
authors.initials: J
authors.lastname: Kundu
authors.forename: Aoune
authors.initials: A
authors.lastname: Barhoumi
authors.forename: Naomi J
authors.initials: NJ
authors.lastname: Halas
mesh_terms: D004247:DNA / Q000032:analysis; D008051:Lipid Bilayers / Q000032:analysis*; D057145:Nanoshells; D010455:Peptides / Q000032:analysis*; D011506:Proteins / Q000032:analysis; D013059:Spectrum Analysis, Raman / Q000379:methods; D020349:Surface Plasmon Resonance / Q000379:methods*
chemical_list: D008051:Lipid Bilayers; D010455:Peptides; D011506:Proteins; D004247:DNA