Aggressive sebaceous carcinoma of the head.
Cutaneous sebaceous carcinoma (SC) is a rare malignancy deriving from the adnexal epithelium of the sebaceous glands. Periorbital SC is approximately three times more common than extraorbital cutaneous SC. Extraocular SC is reported to be less aggressive than orbital sebaceous carcinoma and rarely metastasizes. We report a case of sebaceous carcinoma of the scalp, characterised by highly aggressive behaviour and huge invasion of the intracranial space. The patient was a 79-year-old woman who developed an infiltrating sebaceous carcinoma followed by lymph-node metastases shortly after excision of the primary lesion, resulting in death. In this case, aggressive biological behaviour was observed in a carcinoma arising in an extraorbital area, although it has traditionally been considered a less aggressive neoplasm.
Scuderi
Stefano
S
Department of Clinical Physiopathology, VIth General Surgery Division, Turin University, Turin.
Giaccone
Michele
M
D'Errico
Emanuele
E
Maorenzic
Marcela Alejandra
MA
Fontanellaa
Marco
M
Castellano
Isabella
I
Zanon
Claudio
C
Gaetini
Alessandro Maria
AM
D018266:Adenocarcinoma, Sebaceous / Q000473:pathology* / Q000601:surgery; D000368:Aged; D017809:Fatal Outcome; D005260:Female; D006258:Head and Neck Neoplasms / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008207:Lymphatic Metastasis; D009361:Neoplasm Invasiveness; D012535:Scalp / Q000473:pathology* / Q000601:surgery; D012626:Sebaceous Gland Neoplasms / Q000473:pathology* / Q000601:surgery