title: Surgery and radioablation therapy combined: introducing a 1-week-condensed procedure bonding total thyroidectomy and radioablation therapy with recombinant human TSH.
abstract: OBJECTIVE
  The objective of this study was to determine whether the use of recombinant human TSH (rhTSH) to stimulate radioiodine uptake after thyroidectomy is as efficacious as a period of withholding thyroid hormones, while at the same time avoiding hypothyroidism, reducing sick leave time and shortening the hospital stay.
  
  
  METHODS
  Our aim was to compare the standard procedure of differentiated thyroid cancer treatment, which consists of thyroidectomy followed by 4 weeks of hypothyroidism and a conclusive ablative activity of (131)iodine, with a new shortened treatment in which l-thyroxine (T(4)) medication is initiated a day after thyroidectomy, followed by application of rhTSH stimulation and subsequent ablation a few days after surgery. We presumed our treatment to represent the most sophisticated strategy for the reduction in sick leave days overall without any reduction in safety or the efficacy of ablative therapy.
  
  
  METHODS
  Patients (n=25) were randomized either for surgery and rhTSH stimulation or surgery and l-T(4) abstinence before the first application of radioiodine. Ablation success was determined by neck ultrasound and serum thyroglobulin during follow-up. RhTSH receivers were monitored for an average of 635 days (s.d.+/-289) and patients in l-T(4) abstinence for an average of 624 days (s.d.+/-205). Both groups were statistically compared for significant differences in treatment efficacy, safety and overall time of sick leave.
  
  
  CONCLUSIONS
  Our shortened treatment proved to be equally efficacious and safe in comparison with the conventional therapy regimen. At the same time, it showed economic advantages through the reduction in average sick leave time from approximately 29 days (l-T(4) abstinence) down to approximately 6 days (rhTSH stimulation) as well as sustaining the patient's quality of life by the complete avoidance of hypothyroidism.
authors.affiliation: Klinik für Viszeral- und Transplantationschirurgie Klinik für Nuklearmedizin, Medizinische Hochschule Hannover, Carl-Neuberg Strasse 1, Rudolf-Pichlmayr Transplantations-Forschungszentrum, OE 6220, D-30625 Hannover, Germany.
authors.forename: Nikos
authors.initials: N
authors.lastname: Emmanouilidis
authors.forename: Jörg A
authors.initials: JA
authors.lastname: Müller
authors.forename: Mark D
authors.initials: MD
authors.lastname: Jäger
authors.forename: Stephan
authors.initials: S
authors.lastname: Kaaden
authors.forename: Fabian A
authors.initials: FA
authors.lastname: Helfritz
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Güner
authors.forename: Holger
authors.initials: H
authors.lastname: Kespohl
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Knitsch
authors.forename: Wolfram H
authors.initials: WH
authors.lastname: Knapp
authors.forename: Jürgen
authors.initials: J
authors.lastname: Klempnauer
authors.forename: Georg F W
authors.initials: GF
authors.lastname: Scheumann
mesh_terms: D000328:Adult; D018265:Carcinoma, Papillary, Follicular / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery*; D015331:Cohort Studies; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000008:administration & dosage* / Q000652:urine; D008297:Male; D008875:Middle Aged; D019275:Radiopharmaceuticals / Q000008:administration & dosage / Q000652:urine; D011994:Recombinant Proteins / Q000008:administration & dosage; D013954:Thyroglobulin / Q000097:blood; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery*; D013965:Thyroidectomy / Q000379:methods*; D013972:Thyrotropin / Q000008:administration & dosage*; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood; D014463:Ultrasonography
chemical_list: D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D011994:Recombinant Proteins; D014284:Triiodothyronine; D013972:Thyrotropin; D013954:Thyroglobulin; D013974:Thyroxine