Selective remodeling: refining neural connectivity at the neuromuscular junction.
A primer on new research by Fuentes-Medel and colleagues explains the important role of non-neural cells in clearing neural debris, which is continuously produced during the normal remodeling processes that establish and maintain neural connectivity.
Chung
Won-Suk
WS
Department of Neurobiology, Stanford University School of Medicine, Stanford, California, USA. wschung@stanford.edu
Barres
Ben A
BA
D000818:Animals; D004330:Drosophila / Q000166:cytology / Q000254:growth & development / Q000378:metabolism; D029721:Drosophila Proteins / Q000378:metabolism; D007814:Larva / Q000166:cytology / Q000254:growth & development / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism; D018613:Microscopy, Confocal; D009132:Muscles / Q000166:cytology / Q000502:physiology; D009457:Neuroglia / Q000166:cytology / Q000502:physiology; D009469:Neuromuscular Junction / Q000166:cytology* / Q000378:metabolism; D017729:Presynaptic Terminals / Q000378:metabolism / Q000502:physiology; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013569:Synapses / Q000378:metabolism / Q000502:physiology*; D009435:Synaptic Transmission
D029721:Drosophila Proteins; D008565:Membrane Proteins; C495322:drpr protein, Drosophila
PLoS Biol. 2009 Aug;7(8):e1000184
19707574
J Neurosci. 2008 Jan 2;28(1):264-78
18171944
Annu Rev Neurosci. 2009;32:383-412
19400716
Curr Opin Neurobiol. 2005 Feb;15(1):101-7
15721751
Hum Mol Genet. 2000 Mar 1;9(4):645-51
10699188
Nature. 2007 Nov 15;450(7168):430-4
17960134
Neurosci Lett. 1998 Jun 5;248(3):159-62
9654333
Cell. 2001 Jan 12;104(1):43-56
11163239
Science. 2005 May 27;308(5726):1314-8
15831717
Neuron. 2006 Jun 15;50(6):869-81
16772169
Neuron. 2003 Jan 9;37(1):67-73
12526773
Neuron. 2008 Mar 13;57(5):705-18
18341991
Glia. 1997 Jun;20(2):145-54
9179599
Neuron. 1996 Oct;17(4):655-67
8893023
Neuron. 2004 Nov 18;44(4):651-61
15541313
Semin Cell Dev Biol. 2005 Apr;16(2):295-306
15797839
Curr Opin Neurobiol. 2007 Feb;17(1):73-80
17254766
Proc Natl Acad Sci U S A. 2006 May 16;103(20):7841-6
16682643
Neuron. 2006 Jun 15;50(6):883-95
16772170
Curr Biol. 2004 Apr 20;14(8):678-84
15084282
J Cell Sci. 2005 Feb 1;118(Pt 3):539-53
15673687
Hum Reprod Update. 1998 Nov-Dec;4(6):763-75
10098468
Annu Rev Neurosci. 2007;30:79-97
17280523
Annu Rev Neurosci. 2005;28:127-56
16022592
Neuron. 2006 Oct 19;52(2):281-91
17046691
Cell. 2007 Dec 14;131(6):1164-78
18083105
Curr Opin Neurobiol. 2005 Oct;15(5):549-56
16143509
PLoS Biol. 2008 Mar 18;6(3):e61
18351800
Cell. 2008 May 2;133(3):498-509
18455990