Plasmapheresis treatment of antibody-mediated rejection in an A2 donor to O pediatric liver transplant recipient.
It is safe to transplant kidneys from blood group A2 donors into O recipients if the latter have low titers of anti-A antibodies. However, in liver transplantation, O and B recipients of A2 donor livers are not routinely screened for anti-blood group antibodies because of the immuno-absorptive capacity of the liver and the low incidence of antibody-mediated rejection. Herein, we report a rare case of combined cell and antibody-mediated rejection in a pediatric blood group O recipient of an A2 donor liver, and rescue of the allograft using PP and IVIG.
Martin
T
T
Division of GI/Hepatology and Liver Transplantation, Department of Pediatrics, University of Utah Hospital, Salt Lake City, UT 84113, USA. triscia.martin@hsc.utah.edu
Schwartz
J
J
Demetris
A
A
Comstock
J
J
Lowichik
A
A
Book
L
L
D000293:Adolescent; D001706:Biopsy; D001787:Blood Group Incompatibility; D058625:End Stage Liver Disease / Q000628:therapy*; D005260:Female; D006084:Graft Rejection; D006801:Humans; D056724:Immunity, Humoral; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007223:Infant; D007249:Inflammation; D007511:Ischemia; D016031:Liver Transplantation / Q000379:methods*; D010956:Plasmapheresis / Q000379:methods*; D014184:Transplantation, Homologous / Q000379:methods
D007166:Immunosuppressive Agents