title: Bone hydatid disease refractory to nitazoxanide treatment.
abstract: We report a patient with bone hydatid disease that was refractory to both long-term daily treatment with albendazole, combined with cimetidine or administered as monotherapy ( approximately 15 years) and a relatively short course of nitazoxanide combined with albendazole (3 months). Despite continuous daily medical treatment, bone invasion and destruction proceeded. His pain and disability progressively increased.
authors.affiliation: Department of Internal Medicine, Division of Infectious Diseases, Tropical Medicine and AIDS, Amsterdam, The Netherlands. H.G.Schipper@amc.uva.nl
authors.forename: Hans G
authors.initials: HG
authors.lastname: Schipper
authors.forename: Suat
authors.initials: S
authors.lastname: Simsek
authors.forename: Michiel A
authors.initials: MA
authors.lastname: van Agtmael
authors.forename: Krijn P
authors.initials: KP
authors.lastname: van Lienden
mesh_terms: D000328:Adult; D015766:Albendazole / Q000008:administration & dosage / Q000627:therapeutic use; D000871:Anthelmintics / Q000008:administration & dosage / Q000627:therapeutic use*; D001847:Bone Diseases / Q000188:drug therapy* / Q000469:parasitology / Q000473:pathology; D002927:Cimetidine / Q000008:administration & dosage / Q000627:therapeutic use; D004351:Drug Resistance; D004443:Echinococcosis / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D006635:Histamine H2 Antagonists / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D008159:Lumbar Vertebrae / Q000469:parasitology / Q000473:pathology / Q000601:surgery; D008297:Male; D009574:Nitro Compounds; D013844:Thiazoles / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000871:Anthelmintics; D006635:Histamine H2 Antagonists; D009574:Nitro Compounds; D013844:Thiazoles; D002927:Cimetidine; D015766:Albendazole; C041747:nitazoxanide