[Results of adjuvant chemoradiation after curative surgery for gastric cancer: a retrospective study].
BACKGROUND
Survival rates after curative surgery for gastric cancer are disappointing. Therefore adjuvant therapeutic strategies are required.


OBJECTIVE
To analyze survival and side effects of treatment among gastric cancer patients treated with adjuvant chemo radiotherapy after curative resection of gastric adenocarcinoma.


METHODS
Retrospective review of medical records of 74 patients aged 20 to 74 years, treated with complete resection of gastric adenocarcinoma followed by adjuvant chemo radiation. Survival analysis was based on the records and information from the National Mortality Registry.


RESULTS
Five years survival fluctuated from 50% among patients in stage IB to 25% among those is stage IV. Significant acute toxicity was observed in 23 patients (31%). No patients died due to acute toxicity. Eleven patients (16.4%) developed significant late toxicity, with two possible deaths related to treatment.


CONCLUSIONS
Postoperative chemo radiotherapy is feasible in our experience. Continues infusion of 5-fluoruracil is recommended to reduce toxicity.
Müller
Bettina
B
Servicio de Oncología Médica, Instituto Nacional del Cáncer, Santiago, Chile. bmuller@incancer.cl
Balbontín
Paulina
P
Cárcamo
Marcela
M
Trujillo
Cristian
C
Becerra
Sergio
S
Solá
Antonio
A
Neveu
Rodrigo
R
Fernández
Roberto
R
Buchholtz
Martín
M
Villanueva
Luis
L
Cerda
Berta
B
D000230:Adenocarcinoma / Q000401:mortality / Q000628:therapy*; D000328:Adult; D000368:Aged; D017024:Chemotherapy, Adjuvant / Q000009:adverse effects; D018572:Disease-Free Survival; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D018714:Radiotherapy, Adjuvant / Q000009:adverse effects; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000401:mortality / Q000628:therapy*; D016019:Survival Analysis; D016896:Treatment Outcome; D055815:Young Adult