The chemistry of Alzheimer's disease.
The chemistry of Alzheimer's disease is largely centred on the amyloid beta-peptide, its formation, structure, and interactions with metals, membranes, proteins and other species. This critical review summarizes the current state of knowledge (252 references).
Rauk
Arvi
A
Department of Chemistry, University of Calgary, Calgary, AB, Canada T2N 1N4. rauk@ucalgary.ca
D000544:Alzheimer Disease / Q000188:drug therapy / Q000378:metabolism; D016229:Amyloid beta-Peptides / Q000737:chemistry / Q000378:metabolism; D000818:Animals; D003300:Copper; D005609:Free Radicals; D006801:Humans; D051379:Mice; D008958:Models, Molecular; D010084:Oxidation-Reduction; D011485:Protein Binding; D055503:Protein Multimerization / Q000187:drug effects
D016229:Amyloid beta-Peptides; D005609:Free Radicals; D003300:Copper