Is Gas6 protein associated with sticky platelet syndrome?
The aim of this study was to detect the prevalence of the polymorphisms of growth arrest-specific gene 6 (Gas6; Gas6 c. 834 + 7G > A) in patients with sticky platelet syndrome (SPS). Sticky platelet syndrome is a hereditary, autosomal dominant thrombophilia characterized by platelet hyperaggregation after low concentrations of platelet inducers-adenosine diphosphate (ADP) and epinephrine (EPI). The cause of SPS still remains unknown, but in recent years it was suggested that Gas6 protein may have a potential role in the pathogenesis of SPS. To assess the Gas6 polymorphisms (Gas6 c. 834 + 7G > A), 128 patients with SPS were included in the study and examined by polymerase chain reaction (PCR) method. GG genotype was detected in 63 (49.2%) patients, GA genotype in 53 (41.4%) patients, and AA genotype in 12 (9.4%) patients. The results in controls did not differ significantly compared to patients with SPS. Our findings did not prove allele A to be less associated with thrombosis and that ''prothrombotic'' allele G may be associated with higher risk of thrombosis. We cannot support the idea that Gas6 protein and Gas6 polymorphisms may be associated with thrombosis in SPS.
Kubisz
Peter
P
Clinic of Hematology and Transfusiology, National Center of Hemostasis and Thrombosis, Comenius University, Martin, Slovakia. kubisz@jfmed.uniba.sk
Bartosová
Lenka
L
Ivanková
Jela
J
Holly
Pavol
P
Stasko
Ján
J
Skerenová
Mária
M
Pullmann
Rudolf
R
D000328:Adult; D001157:Arterial Occlusive Diseases / Q000097:blood / Q000235:genetics*; D001791:Blood Platelet Disorders / Q000097:blood / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D013577:Syndrome; D000099255:Growth Arrest-Specific Protein 6
D036341:Intercellular Signaling Peptides and Proteins; D000099255:Growth Arrest-Specific Protein 6