Pressure-driven transport of particles through a converging-diverging microchannel.
Pressure-driven transport of particles through a symmetric converging-diverging microchannel is studied by solving a coupled nonlinear system, which is composed of the Navier-Stokes and continuity equations using the arbitrary Lagrangian-Eulerian finite-element technique. The predicted particle translation is in good agreement with existing experimental observations. The effects of pressure gradient, particle size, channel geometry, and a particle's initial location on the particle transport are investigated. The pressure gradient has no effect on the ratio of the translational velocity of particles through a converging-diverging channel to that in the upstream straight channel. Particles are generally accelerated in the converging region and then decelerated in the diverging region, with the maximum translational velocity at the throat. For particles with diameters close to the width of the channel throat, the usual acceleration process is divided into three stages: Acceleration, deceleration, and reacceleration instead of a monotonic acceleration. Moreover, the maximum translational velocity occurs at the end of the first acceleration stage rather than at the throat. Along the centerline of the microchannel, particles do not rotate, and the closer a particle is located near the channel wall, the higher is its rotational velocity. Analysis of the transport of two particles demonstrates the feasibility of using a converging-diverging microchannel for passive (biological and synthetic) particle separation and ordering.
Ai
Ye
Y
Joo
Sang W
SW
Jiang
Yingtao
Y
Xuan
Xiangchun
X
Qian
Shizhi
S
J Colloid Interface Sci. 2008 Jan 15;317(2):620-30
17949729
Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):3853-7
12629208
Lab Chip. 2003 Nov;3(4):217-20
15007448
Lab Chip. 2007 Nov;7(11):1532-8
17960282
Electrophoresis. 2009 Jul;30(14):2499-506
19639572
Lab Chip. 2007 Dec;7(12):1644-59
18030382
Cytometry A. 2004 Jun;59(2):246-53
15170604
J Biomech. 2007;40(9):2088-95
17188279
Anal Chem. 2005 Jul 15;77(14):4323-8
16013842
J Colloid Interface Sci. 2005 Sep 1;289(1):286-90
16009235
Lab Chip. 2006 Sep;6(9):1187-99
16929398
J Colloid Interface Sci. 2004 Apr 15;272(2):480-8
15028514
J Colloid Interface Sci. 2006 Nov 1;303(1):288-97
16920138
Biotechnol Appl Biochem. 2009 Jan;52(Pt 1):29-40
18251714
J Colloid Interface Sci. 2006 Nov 15;303(2):579-92
16979648
Biomicrofluidics. 2009 Jan 07;3(1):12803
19693392
Proc Natl Acad Sci U S A. 2006 Oct 24;103(43):15853-8
17047033
Anal Chem. 2008 Mar 15;80(6):2204-11
18275222
Lab Chip. 2003 Feb;3(1):34-9
15100803
Proc Natl Acad Sci U S A. 2007 Nov 27;104(48):18892-7
18025477
Curr Opin Chem Biol. 2006 Dec;10(6):584-91
17056296
Nat Rev Drug Discov. 2006 Mar;5(3):210-8
16518374
Electrophoresis. 2004 Nov;25(21-22):3720-9
15565695
Biomed Microdevices. 2008 Apr;10(2):243-9
17899384