title: Environment-mediated drug resistance: a major contributor to minimal residual disease.
abstract: Environment-mediated drug resistance is a form of de novo drug resistance that protects tumour cells from the initial effects of diverse therapies. Surviving foci of residual disease can then develop complex and permanent acquired resistance in response to the selective pressure of therapy. Recent evidence indicates that environment-mediated drug resistance arises from an adaptive, reciprocal signalling dialogue between tumour cells and the surrounding microenvironment. We propose that new therapeutic strategies targeting this interaction should be applied during initial treatment to prevent the emergence of acquired resistance.
authors.affiliation: Department of Experimental Therapeutics and Oncologic Sciences, H. Lee Moffitt Cancer Center, Florida 33612, USA.
authors.forename: Mark B
authors.initials: MB
authors.lastname: Meads
authors.forename: Robert A
authors.initials: RA
authors.lastname: Gatenby
authors.forename: William S
authors.initials: WS
authors.lastname: Dalton
mesh_terms: D019008:Drug Resistance, Neoplasm; D006801:Humans; D018365:Neoplasm, Residual / Q000473:pathology*; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D015398:Signal Transduction / Q000187:drug effects*; D017154:Stromal Cells / Q000187:drug effects* / Q000473:pathology
references.citation: Eur J Haematol. 2007 Sep;79(3):240-3
references.pmid: 17655704
references.citation: Clin Cancer Res. 2007 Apr 1;13(7):2128-35
references.pmid: 17404096
references.citation: Nat Med. 2008 May;14(5):518-27
references.pmid: 18438415
references.citation: Cancer Res. 1996 Sep 15;56(18):4146-9
references.pmid: 8797583
references.citation: J Clin Oncol. 2000 Jan;18(1):80-6
references.pmid: 10623696
references.citation: Cancer Cell. 2004 Aug;6(2):159-70
references.pmid: 15324699
references.citation: Nat Med. 2004 Mar;10(3):294-8
references.pmid: 14981514
references.citation: J Exp Med. 2007 Jan 22;204(1):49-55
references.pmid: 17210731
references.citation: J Clin Oncol. 2008 Dec 1;26(34):5610-7
references.pmid: 18981465
references.citation: Cancer Res. 2004 May 1;64(9):3215-22
references.pmid: 15126362
references.citation: J Immunol. 2008 Feb 1;180(3):1545-55
references.pmid: 18209050
references.citation: Annu Rev Pathol. 2006;1:119-50
references.pmid: 18039110
references.citation: Clin Cancer Res. 2006 Sep 1;12(17):5055-63
references.pmid: 16951221
references.citation: Blood. 2008 Oct 1;112(7):2935-45
references.pmid: 18535198
references.citation: Br J Haematol. 2007 Jan;136(2):269-75
references.pmid: 17233818
references.citation: Cell Death Differ. 2006 Oct;13(10):1776-88
references.pmid: 16410797
references.citation: Cancer Res. 2008 Jun 1;68(11):4398-405
references.pmid: 18519702
references.citation: Cancer Res. 2004 May 1;64(9):3191-7
references.pmid: 15126359
references.citation: Cell. 2005 May 6;121(3):335-48
references.pmid: 15882617
references.citation: Melanoma Res. 2007 Aug;17(4):215-23
references.pmid: 17625451
references.citation: Melanoma Res. 2004 Feb;14(1):29-37
references.pmid: 15091191
references.citation: Cancer Res. 2006 Feb 15;66(4):2338-45
references.pmid: 16489039
references.citation: Leukemia. 2004 Dec;18(12):1981-8
references.pmid: 15470488
references.citation: PLoS One. 2008 Feb 13;3(2):e1592
references.pmid: 18270579
references.citation: Clin Cancer Res. 2005 Nov 1;11(21):7851-60
references.pmid: 16278408
references.citation: J Biol Chem. 2005 Nov 4;280(44):37266-77
references.pmid: 16105842
references.citation: Cancer. 1999 Jan 1;85(1):134-44
references.pmid: 9921985
references.citation: Clin Cancer Res. 2005 Apr 1;11(7):2540-6
references.pmid: 15814631
references.citation: Blood. 2003 Apr 1;101(7):2775-83
references.pmid: 12517814
references.citation: Cancer Res. 1991 Feb 1;51(3):995-1002
references.pmid: 1988143
references.citation: N Engl J Med. 2008 Aug 28;359(9):906-17
references.pmid: 18753647
references.citation: J Natl Cancer Inst. 1993 Sep 1;85(17):1419-24
references.pmid: 7688814
references.citation: Cancer Cell. 2004 Jul;6(1):17-32
references.pmid: 15261139
references.citation: Blood. 2001 Jan 15;97(2):346-51
references.pmid: 11154207
references.citation: Nat Med. 2003 Sep;9(9):1158-65
references.pmid: 12897778
references.citation: Blood. 2007 Sep 1;110(5):1631-8
references.pmid: 17502456
references.citation: Trends Genet. 2009 Jan;25(1):30-8
references.pmid: 19054589
references.citation: N Engl J Med. 2005 Aug 25;353(8):793-802
references.pmid: 16120859
references.citation: Blood. 2004 Sep 15;104(6):1825-32
references.pmid: 15161667
references.citation: Proc Natl Acad Sci U S A. 2000 Aug 29;97(18):10026-31
references.pmid: 10944199
references.citation: Hematol Oncol. 2009 Mar;27(1):17-22
references.pmid: 18668701
references.citation: Immunity. 1999 Jan;10(1):105-15
references.pmid: 10023775
references.citation: Br J Cancer. 2006 Jun 5;94(11):1621-6
references.pmid: 16705310
references.citation: J Immunol. 2002 Mar 1;168(5):2544-53
references.pmid: 11859150
references.citation: Oncogene. 2003 Apr 24;22(16):2417-21
references.pmid: 12717418
references.citation: Blood. 2000 Apr 15;95(8):2630-6
references.pmid: 10753844
references.citation: J Cell Biochem. 2007 Oct 15;102(3):704-18
references.pmid: 17407140
references.citation: Clin Cancer Res. 2009 Jan 15;15(2):520-31
references.pmid: 19147757
references.citation: Clin Cancer Res. 2008 Jun 1;14(11):3306-11
references.pmid: 18519757
references.citation: Clin Cancer Res. 2004 Aug 15;10(16):5342-8
references.pmid: 15328170
references.citation: N Engl J Med. 2008 Nov 27;359(22):2313-23
references.pmid: 19038878
references.citation: Blood. 2001 Jan 15;97(2):483-9
references.pmid: 11154226
references.citation: Leuk Lymphoma. 2008 Jan;49(1):134-48
references.pmid: 17926185
references.citation: Cancer Treat Rep. 1983 Oct;67(10):923-31
references.pmid: 6627236
references.citation: Clin Cancer Res. 2007 Nov 1;13(21):6469-78
references.pmid: 17975159
references.citation: Am J Hematol. 2006 Apr;81(4):227-35
references.pmid: 16550517
references.citation: Science. 1999 Dec 3;286(5446):1946-9
references.pmid: 10583956
references.citation: J Histochem Cytochem. 2009 Mar;57(3):239-47
references.pmid: 19001640
references.citation: J Cell Biol. 1997 Apr 7;137(1):231-45
references.pmid: 9105051
references.citation: Clin Cancer Res. 2003 Sep 1;9(10 Pt 1):3808-14
references.pmid: 14506175
references.citation: Leukemia. 2003 Jun;17(6):1175-82
references.pmid: 12764386
references.citation: J Biol Chem. 1998 Jan 16;273(3):1662-9
references.pmid: 9430710
references.citation: J Clin Oncol. 2002 Apr 15;20(8):2005-16
references.pmid: 11956259
references.citation: Nat Med. 1996 Nov;2(11):1204-10
references.pmid: 8898746
references.citation: Anticancer Res. 2002 Mar-Apr;22(2B):1065-70
references.pmid: 12168902
references.citation: N Engl J Med. 2006 Jan 12;354(2):166-78
references.pmid: 16407512
references.citation: Blood. 1996 Jun 15;87(12):5251-6
references.pmid: 8652840
references.citation: Leukemia. 2004 Aug;18(8):1380-90
references.pmid: 15201848
references.citation: Cancer Cell. 2003 Apr;3(4):377-86
references.pmid: 12726863
references.citation: Leukemia. 2008 Feb;22(2):353-60
references.pmid: 17972943
references.citation: Blood. 2005 Jan 15;105(2):821-6
references.pmid: 15388585
references.citation: Endocrinology. 2003 Feb;144(2):681-92
references.pmid: 12538631
references.citation: Blood. 2009 Jul 16;114(3):619-29
references.pmid: 19443661
references.citation: Cancer Res. 2002 Apr 1;62(7):2162-8
references.pmid: 11929839
references.citation: Blood. 1999 Mar 1;93(5):1658-67
references.pmid: 10029595
references.citation: Proc Natl Acad Sci U S A. 1990 Sep;87(17):6698-702
references.pmid: 2168554
references.citation: Blood. 2007 Aug 15;110(4):1271-7
references.pmid: 17456722
references.citation: Blood. 2005 Sep 1;106(5):1824-30
references.pmid: 15905192
references.citation: Blood. 2004 May 1;103(9):3503-10
references.pmid: 14670925
references.citation: J Natl Cancer Inst. 1996 Sep 18;88(18):1285-96
references.pmid: 8797768
references.citation: Oncogene. 2000 Sep 7;19(38):4319-27
references.pmid: 10980607
references.citation: Clin Cancer Res. 2008 May 1;14(9):2519-26
references.pmid: 18451212
references.citation: J Clin Oncol. 2007 May 1;25(13):1637-8
references.pmid: 17470853
references.citation: J Biol Chem. 2004 Jan 23;279(4):2657-65
references.pmid: 14613935
references.citation: Blood. 2009 Jun 11;113(24):6215-24
references.pmid: 18955566
references.citation: Nat Med. 2001 Jun;7(6):687-92
references.pmid: 11385505
references.citation: Cell Cycle. 2006 Aug;5(16):1756-9
references.pmid: 16880738
references.citation: Cancer Res. 2008 Mar 1;68(5):1563-71
references.pmid: 18316622
references.citation: Cancer Res. 2007 Jan 15;67(2):659-64
references.pmid: 17234776
references.citation: Cancer Res. 2008 Apr 15;68(8):2717-25
references.pmid: 18413739
references.citation: Cancer Res. 2003 Nov 15;63(22):7900-6
references.pmid: 14633719
references.citation: Nat Med. 1999 Jun;5(6):662-8
references.pmid: 10371505
references.citation: Oncogene. 2005 Jun 23;24(27):4462-71
references.pmid: 15806155
references.citation: Blood. 2004 Oct 1;104(7):2149-54
references.pmid: 15138161
references.citation: Cancer Res. 2009 Feb 1;69(3):1009-15
references.pmid: 19155309
references.citation: Cell Signal. 2003 Mar;15(3):327-38
references.pmid: 12531431
references.citation: Blood. 2009 Jan 22;113(4):866-74
references.pmid: 18927435
references.citation: Cancer Treat Rep. 1979 Nov-Dec;63(11-12):1727-33
references.pmid: 526911
references.citation: Oncogene. 2006 Mar 2;25(9):1378-90
references.pmid: 16247454
references.citation: Science. 1990 Mar 23;247(4949 Pt 1):1457-61
references.pmid: 2108497
references.citation: Leukemia. 2007 Jan;21(1):158-63
references.pmid: 17096013
references.citation: J Biol Chem. 2004 Nov 5;279(45):46764-71
references.pmid: 15304496
references.citation: Cancer Res. 2006 Feb 1;66(3):1526-35
references.pmid: 16452209
references.citation: Biochem Biophys Res Commun. 2003 Nov 21;311(3):708-12
references.pmid: 14623330
references.citation: Br J Haematol. 2008 Nov;143(4):481-9
references.pmid: 18710378
references.citation: Blood. 2006 Aug 1;108(3):1050-7
references.pmid: 16627760
references.citation: Nat Rev Mol Cell Biol. 2003 Oct;4(10):767-76
references.pmid: 14570053
references.citation: Cancer Res. 2002 Sep 1;62(17):5019-26
references.pmid: 12208756