title: Thyrotoxicosis due to functioning metastatic follicular thyroid carcinoma after twelve I-131 therapies.
abstract: We present a case of functioning metastatic follicular thyroid carcinoma (FTC) causing severe thyrotoxicosis despite four years 12 iodine-131 therapies (1.461 Ci cumulatively). Initially, the patient had ostalgia and fracture in the right femur. Surgery-confirmed metastatic bone FTC and thyroidectomy-confirmed FTC. One month later, iodine-131 treatment commenced. During the follow-up, different metastatic sites showed different outcomes. Lung metastases disappeared, a thigh metastasis persisted, a new metastasis in the head occurred and pelvic metastases deteriorated into a huge mass elevating thyroglobulin and causing thyrotoxicosis within 3 months. Presurgical PET/CT also demonstrated the massiveness of the pelvic metastases. Thyrotoxicosis disappeared after surgical removal of the pelvic lesion.
authors.affiliation: Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin, People's Republic of China.
authors.forename: Jian
authors.initials: J
authors.lastname: Tan
authors.forename: Guizhi
authors.initials: G
authors.lastname: Zhang
authors.forename: Wengui
authors.initials: W
authors.lastname: Xu
authors.forename: Zhaowei
authors.initials: Z
authors.lastname: Meng
authors.forename: Feng
authors.initials: F
authors.lastname: Dong
authors.forename: Fuhai
authors.initials: F
authors.lastname: Zhang
authors.forename: Qiang
authors.initials: Q
authors.lastname: Jia
authors.forename: Xuehui
authors.initials: X
authors.lastname: Liu
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D009362:Neoplasm Metastasis; D049268:Positron-Emission Tomography; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000532:radiotherapy*; D013971:Thyrotoxicosis / Q000209:etiology*; D014057:Tomography, X-Ray Computed
chemical_list: D007457:Iodine Radioisotopes