title: Fc-receptors and immunity to malaria: from models to vaccines.
abstract: The complexity and number of antigens (Ags) seen during an immune response has hampered the development of malaria vaccines. Antibodies (Abs) play an important role in immunity to malaria and their passive administration is effective at controlling the disease. Abs represent approximately 25% of all proteins undergoing clinical trials, and these 'smart biologicals' have undergone a major revival with the realization that Abs lie at the interface between innate and adaptive immunity. At least 18 Abs have FDA approval for clinical use and approximately 150 are in clinical trials, the majority for the treatment of cancer, allograft rejection or autoimmune disease. Despite these triumphs none are in development for malaria, principally because they are perceived as being too expensive for a disease mainly afflicting poor and marginalized populations. Although unlikely, at least in the foreseeable future, that Ab-based prophylaxis will be made available to the millions of people at risk from malaria, they may be incorporated into current vaccine approaches, since Abs act as correlates of protection in studies aimed at defining the best Ags to include in vaccines. Abs may also form the basis for novel vaccination strategies by targeting Ags to appropriate antigen presenting cells. Therefore, to develop the most efficacious vaccines it will be necessary to fully understand which Abs and Fc-receptors (FcRs) are best engaged for a positive outcome.
authors.affiliation: Institute of Genetics, Queen's Medical Centre, Nottingham NG7 2UH, UK. richard.pleass@nottingham.ac.uk
authors.forename: R J
authors.initials: RJ
authors.lastname: Pleass
mesh_terms: D000818:Animals; D006801:Humans; D008288:Malaria / Q000517:prevention & control*; D017780:Malaria Vaccines / Q000276:immunology*; D011961:Receptors, Fc / Q000276:immunology*
chemical_list: D017780:Malaria Vaccines; D011961:Receptors, Fc
references.citation: Immunity. 2008 Oct 17;29(4):578-88
references.pmid: 18835194
references.citation: Proc Natl Acad Sci U S A. 2005 Feb 22;102(8):2910-5
references.pmid: 15703291
references.citation: Blood. 1999 Jul 15;94(2):808-17
references.pmid: 10397749
references.citation: Proc Natl Acad Sci U S A. 2007 Apr 24;104(17):7169-74
references.pmid: 17435165
references.citation: Blood. 2009 Apr 16;113(16):3716-25
references.pmid: 19018092
references.citation: Monogr Allergy. 1986;19:40-51
references.pmid: 2429173
references.citation: Infect Immun. 1998 Aug;66(8):3925-30
references.pmid: 9673281
references.citation: Adv Immunol. 1999;72:149-77
references.pmid: 10361574
references.citation: J Exp Med. 1995 Aug 1;182(2):409-18
references.pmid: 7629503
references.citation: Nature. 1987 May 7-13;327(6117):59-61
references.pmid: 3472080
references.citation: Blood. 2003 Dec 15;102(13):4424-30
references.pmid: 12855589
references.citation: Semin Immunol. 1990 Nov;2(6):457-66
references.pmid: 2104282
references.citation: J Immunol. 2007 Jul 1;179(1):236-46
references.pmid: 17579043
references.citation: J Exp Med. 1999 Jan 18;189(2):371-80
references.pmid: 9892619
references.citation: Immunol Lett. 2006 Apr 15;104(1-2):46-52
references.pmid: 16448704
references.citation: Proc Natl Acad Sci U S A. 2008 Jul 8;105(27):9337-42
references.pmid: 18599440
references.citation: Trends Immunol. 2008 Aug;29(8):366-73
references.pmid: 18602341
references.citation: J Biol Chem. 2008 Jun 20;283(25):17615-23
references.pmid: 18411272
references.citation: Immunol Rev. 2004 Oct;201:268-90
references.pmid: 15361247
references.citation: Nat Rev Immunol. 2008 Jan;8(1):34-47
references.pmid: 18064051
references.citation: Nature. 2008 Dec 18;456(7224):989-92
references.pmid: 19011614
references.citation: Infect Immun. 2004 Sep;72(9):5412-8
references.pmid: 15322039
references.citation: J Exp Med. 2006 Jun 12;203(6):1603-14
references.pmid: 16754720
references.citation: J Immunol. 2008 Aug 1;181(3):1988-2000
references.pmid: 18641336
references.citation: Eur J Immunol. 2007 Dec;37(12):3540-50
references.pmid: 18000956
references.citation: J Immunol. 1998 Aug 15;161(4):1908-12
references.pmid: 9712060
references.citation: J Immunol. 2007 Mar 15;178(6):3702-12
references.pmid: 17339468
references.citation: Eur J Immunol. 2008 May;38(5):1341-50
references.pmid: 18398934
references.citation: Antimicrob Agents Chemother. 1994 Jul;38(7):1507-14
references.pmid: 7979280
references.citation: Nat Immunol. 2007 Jul;8(7):762-71
references.pmid: 17558411
references.citation: Immunity. 2005 Nov;23(5):503-14
references.pmid: 16286018
references.citation: Science. 2007 Sep 14;317(5844):1554-7
references.pmid: 17872445
references.citation: Nat Immunol. 2000 Nov;1(5):441-6
references.pmid: 11062505
references.citation: J Exp Med. 2002 Jan 7;195(1):125-33
references.pmid: 11781371
references.citation: Mol Immunol. 1986 Mar;23(3):319-30
references.pmid: 3487030
references.citation: J Immunol. 2006 Apr 15;176(8):4573-80
references.pmid: 16585547
references.citation: Blood. 2000 Nov 15;96(10):3544-52
references.pmid: 11071653
references.citation: Rheumatology (Oxford). 2007 Sep;46(9):1417-21
references.pmid: 17596285
references.citation: Biochem Biophys Res Commun. 2006 Sep 15;348(1):183-91
references.pmid: 16876123
references.citation: Eur J Immunol. 1995 Jan;25(1):154-8
references.pmid: 7843226
references.citation: Trends Parasitol. 2008 Sep;24(9):392-5
references.pmid: 18675589
references.citation: Ann Trop Med Parasitol. 1998 Apr;92(3):245-56
references.pmid: 9713539
references.citation: J Immunol. 2007 Mar 1;178(5):3099-106
references.pmid: 17312157
references.citation: Infect Immun. 2000 May;68(5):3019-22
references.pmid: 10769007
references.citation: Science. 2005 Dec 2;310(5753):1510-2
references.pmid: 16322460
references.citation: Bioinformatics. 2007 Jul 1;23(13):i159-66
references.pmid: 17646292
references.citation: Eur J Immunol. 2007 Apr;37(4):1139-48
references.pmid: 17393382
references.citation: Parasite Immunol. 2005 May;27(5):171-80
references.pmid: 15987340
references.citation: J Exp Med. 1994 Jul 1;180(1):389-93
references.pmid: 7516416
references.citation: Am J Trop Med Hyg. 2003 Dec;69(6):565-8
references.pmid: 14740869
references.citation: J Immunol. 1998 Jan 1;160(1):20-3
references.pmid: 9551950
references.citation: Nat Med. 2003 Oct;9(10):1287-92
references.pmid: 14502281
references.citation: Clin Sci (Lond). 2006 Jan;110(1):11-9
references.pmid: 16336201
references.citation: J Leukoc Biol. 1991 Jun;49(6):556-65
references.pmid: 1709200
references.citation: Immunity. 2005 Jul;23(1):41-51
references.pmid: 16039578
references.citation: J Exp Med. 1990 Dec 1;172(6):1633-41
references.pmid: 2258697
references.citation: Scand J Immunol Suppl. 1992;11:17-22
references.pmid: 1514035
references.citation: Nature. 1983 Mar 17-23;302(5905):256-8
references.pmid: 6835362
references.citation: Immunol Lett. 2006 Apr 15;104(1-2):38-45
references.pmid: 16364455
references.citation: J Immunol. 2001 Mar 1;166(5):3266-76
references.pmid: 11207281
references.citation: Immunity. 2002 Mar;16(3):379-89
references.pmid: 11911823
references.citation: Infect Immun. 2007 Mar;75(3):1424-35
references.pmid: 17220317
references.citation: Trends Parasitol. 2001 Nov;17(11):545-51
references.pmid: 11872400
references.citation: Immunity. 2002 Mar;16(3):391-402
references.pmid: 11911824
references.citation: Proc Natl Acad Sci U S A. 2004 Jul 13;101(28):10392-7
references.pmid: 15229321
references.citation: Nature. 1988 Apr 21;332(6166):738-40
references.pmid: 3258649
references.citation: Annu Rev Immunol. 1988;6:161-95
references.pmid: 2898251
references.citation: J Exp Med. 1998 Feb 16;187(4):641-8
references.pmid: 9463414
references.citation: J Clin Invest. 2005 Oct;115(10):2914-23
references.pmid: 16167082
references.citation: J Immunol. 2003 Mar 15;170(6):3134-8
references.pmid: 12626570
references.citation: J Mol Biol. 2001 Apr 13;307(5):1381-94
references.pmid: 11292349
references.citation: J Immunol. 2001 May 15;166(10):6236-41
references.pmid: 11342646
references.citation: J Immunol. 2000 Dec 15;165(12):6738-42
references.pmid: 11120792
references.citation: Parasite Immunol. 2009 Feb;31(2):61-3
references.pmid: 19149773
references.citation: J Exp Med. 2002 Jun 17;195(12):1653-9
references.pmid: 12070293
references.citation: J Biol Chem. 2001 Mar 16;276(11):8197-204
references.pmid: 11096107
references.citation: Infect Immun. 1992 Sep;60(9):3731-8
references.pmid: 1500183
references.citation: Eur J Immunol. 2009 Apr;39(4):1147-56
references.pmid: 19266484
references.citation: Nat Rev Microbiol. 2005 Nov;3(11):893-9
references.pmid: 16261172
references.citation: Science. 2006 Jul 21;313(5785):308-9
references.pmid: 16857927
references.citation: PLoS Pathog. 2007 May 18;3(5):e72
references.pmid: 17511516
references.citation: Infect Immun. 2001 Jun;69(6):3853-9
references.pmid: 11349051
references.citation: J Exp Med. 2008 May 12;205(5):1133-43
references.pmid: 18426986