title: Early features in frontotemporal dementia.
abstract: Frontotemporal dementia is a disorder of paralimbic prefrontal-insular circuitry. The disorder is often sporadic but can be caused by genetic mutations in tau, progranulin, valosin, TDP-43 and CHMP2b. The major clinical manifestations of FTD include addictive behaviors, disinhibition, apathy, overeating and loss of sympathy and empathy for others. Treatment is currently focused around symptoms but disease-modifying therapies seem feasible.
authors.affiliation: Memory and Aging Center, Department of Neurology, UCSF, USA. krascovsky@memory.ucsf.edu
authors.forename: Ana María Villamizar
authors.initials: AM
authors.lastname: Caycedo
authors.forename: Bruce
authors.initials: B
authors.lastname: Miller
authors.forename: Joel
authors.initials: J
authors.lastname: Kramer
authors.forename: Katya
authors.initials: K
authors.lastname: Rascovsky
mesh_terms: D000342:Affective Symptoms / Q000503:physiopathology; D001284:Atrophy; D003072:Cognition Disorders / Q000503:physiopathology; D003704:Dementia / Q000175:diagnosis*; D005625:Frontal Lobe / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D013702:Temporal Lobe / Q000473:pathology* / Q000503:physiopathology