title: Trigochilides A and B, two highly modified daphnane-type diterpenoids from Trigonostemon chinensis.
abstract: Trigochilides A (1) and B (2), two highly modified daphnane-type diterpenoids with 12-carbon-containing polyketide appendages at C-16 forming a macro-lactone with C-3, were isolated from the twigs and leaves of Trigonostemon chinensis. Their structures were elucidated by spectroscopic analysis. Trigochilides A (1) showed modest cytotoxicity against two tumor cell lines.
authors.affiliation: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, PR China.
authors.forename: Hua-Dong
authors.initials: HD
authors.lastname: Chen
authors.forename: Xiu-Feng
authors.initials: XF
authors.lastname: He
authors.forename: Jing
authors.initials: J
authors.lastname: Ai
authors.forename: Mei-Yu
authors.initials: MY
authors.lastname: Geng
authors.forename: Jian-Min
authors.initials: JM
authors.lastname: Yue
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004224:Diterpenes / Q000145:classification / Q000627:therapeutic use*; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry; D019665:Euphorbiaceae / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D020014:K562 Cells; D007783:Lactones / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D004224:Diterpenes; D004365:Drugs, Chinese Herbal; D007783:Lactones