title: Extrapyramidal symptoms and medication use in Mucopolysaccharidosis type III.
abstract: BACKGROUND
  We report the case of a 16-year-old male with Mucopolysaccharidosis III type A (Sanfilippo syndrome) who was commenced on risperidone for behaviour management. He rapidly developed extrapyramidal symptoms that have not resolved.
  
  
  METHODS
  The medication histories of 20 patients with Mucopolysaccharidosis III seen at a Lysosomal Storage Diseases Clinic were reviewed to determine the incidence of extrapyramidal side effects.
  
  
  RESULTS
  Six patients had been treated with risperidone, olanzapine, or lamotrigine. Five of these patients developed extrapyramidal side effects.
  
  
  CONCLUSIONS
  The incidence of extrapyramidal side effects was considerably higher than expected. We suggest that these medications be used with considerable caution in these patients.
authors.affiliation: The Children's Hospital at Westmead, Sydney, Australia. michelt@chw.edu.au
authors.forename: Michel C
authors.initials: MC
authors.lastname: Tchan
authors.forename: David
authors.initials: D
authors.lastname: Sillence
mesh_terms: D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001480:Basal Ganglia Diseases / Q000139:chemically induced* / Q000453:epidemiology; D001569:Benzodiazepines / Q000009:adverse effects / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D006801:Humans; D015994:Incidence; D000077213:Lamotrigine; D008297:Male; D001523:Mental Disorders / Q000188:drug therapy* / Q000209:etiology*; D009084:Mucopolysaccharidosis III / Q000523:psychology*; D000077152:Olanzapine; D018967:Risperidone / Q000009:adverse effects / Q000627:therapeutic use; D014227:Triazines / Q000009:adverse effects / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D000927:Anticonvulsants; D014150:Antipsychotic Agents; D014227:Triazines; D001569:Benzodiazepines; D018967:Risperidone; D000077152:Olanzapine; D000077213:Lamotrigine