title: Serotonin transporter availability in the amygdala and bed nucleus of the stria terminalis predicts anxious temperament and brain glucose metabolic activity.
abstract: The serotonin transporter (5-HTT) plays a critical role in regulating serotonergic neurotransmission and is implicated in the pathophysiology of anxiety and affective disorders. Positron emission tomography scans using [(11)C]DASB [(11)C]-3-amino-4-(2-dimethylaminomethylphenylsulfanyl)-benzonitrile] to measure 5-HTT availability (an index of receptor density and binding) were performed in 34 rhesus monkeys in which the relationship between regional brain glucose metabolism and anxious temperament was previously established. 5-HTT availability in the amygdalohippocampal area and bed nucleus of the stria terminalis correlated positively with individual differences in a behavioral and neuroendocrine composite of anxious temperament. 5-HTT availability also correlated positively with stress-induced metabolic activity within these regions. Collectively, these findings suggest that serotonergic modulation of neuronal excitability in the neural circuitry associated with anxiety mediates the developmental risk for affect-related psychopathology.
authors.affiliation: Departments of Psychiatry, HealthEmotions Research Institute, University of Wisconsin-Madison, 53719, USA.
authors.forename: Jonathan A
authors.initials: JA
authors.lastname: Oler
authors.forename: Andrew S
authors.initials: AS
authors.lastname: Fox
authors.forename: Steven E
authors.initials: SE
authors.lastname: Shelton
authors.forename: Bradley T
authors.initials: BT
authors.lastname: Christian
authors.forename: Dhanabalan
authors.initials: D
authors.lastname: Murali
authors.forename: Terrence R
authors.initials: TR
authors.lastname: Oakes
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Davidson
authors.forename: Ned H
authors.initials: NH
authors.lastname: Kalin
mesh_terms: D000679:Amygdala / Q000000981:diagnostic imaging / Q000502:physiology*; D000814:Aniline Compounds; D000818:Animals; D001007:Anxiety / Q000000981:diagnostic imaging / Q000503:physiopathology*; D001522:Behavior, Animal; D005260:Female; D019788:Fluorodeoxyglucose F18; D005947:Glucose / Q000378:metabolism*; D016014:Linear Models; D008253:Macaca mulatta; D008297:Male; D049268:Positron-Emission Tomography; D012686:Septal Nuclei / Q000000981:diagnostic imaging / Q000502:physiology*; D050486:Serotonin Plasma Membrane Transport Proteins / Q000378:metabolism*; D013440:Sulfides; D013694:Temperament / Q000502:physiology*
chemical_list: C412822:3-amino-4-(2-dimethylaminomethylphenylsulfanyl)benzonitrile; D000814:Aniline Compounds; D050486:Serotonin Plasma Membrane Transport Proteins; D013440:Sulfides; D019788:Fluorodeoxyglucose F18; D005947:Glucose
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