[Aml1 gene abnormality in pediatric acute leukemia-review].
Acute leukemia, the most common cancer in childhood, affects children's health severely, whereas the pathogeny and mechanism have not been elucidated clearly yet. As many studies showed, it has been found that transformation of cytogenetics plays a crucial role in leukemia development, and is frequently involved in the transforming action of aml1 gene, one of which is essential for regulation of normal hematogenesis. Moreover, in children acute leukemia, more than one third children with acute leukemia can be detected with dysfunction of the aml1 gene. Our findings highlight the translocation of aml1 gene in children acute leukemia, indicating its mechanism, especailly provide a new target for clinical diagnosis and therapy. In this review, the structure and function of aml1 gene, the abnormality of aml1 gene in acute lymphocytic leukemia, abnormality of aml1 gene in acute myeloid leukemia and so on were summarized.
Wang
Xiao-Dong
XD
Department of Pediatric Hematology/Oncology, Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China.
Chen
Jing
J
D002648:Child; D050676:Core Binding Factor Alpha 2 Subunit / Q000235:genetics*; D006801:Humans; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*
D050676:Core Binding Factor Alpha 2 Subunit; C493728:RUNX1 protein, human