title: Stem cell donation--what advice can be given to the donor?
abstract: Haematopoietic stem cell transplantation (HSCT) is widely used to treat patients with a range of haematological and non-haematological disorders. Both bone marrow and peripheral blood stem cell collection are associated with morbidity and, very rarely, mortality. We investigated the information that exists to adequately inform donors about the relative merits of each procedure. We carried out a systematic review analysing data from six prospective randomised controlled trials of related donors and discuss here the merits and drawbacks of this approach. Registry data mostly describes patient outcome but stem cell donor registries collect and report information on unrelated donors which could easily be extended to related donors. Further well-designed, randomised studies are required.
authors.affiliation: NHS Blood and Transplant Bristol Centre, Bristol, UK. derwood.pamphilon@nhsbt.nhs.uk
authors.forename: Derwood
authors.initials: D
authors.lastname: Pamphilon
authors.forename: Samreen
authors.initials: S
authors.lastname: Siddiq
authors.forename: Susan
authors.initials: S
authors.lastname: Brunskill
authors.forename: Carolyn
authors.initials: C
authors.lastname: Dorée
authors.forename: Chris
authors.initials: C
authors.lastname: Hyde
authors.forename: Mary
authors.initials: M
authors.lastname: Horowitz
authors.forename: Simon
authors.initials: S
authors.lastname: Stanworth
mesh_terms: D046148:Donor Selection / Q000592:standards; D019317:Evidence-Based Medicine / Q000379:methods; D006266:Health Education / Q000379:methods*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D016032:Randomized Controlled Trials as Topic / Q000379:methods; D012042:Registries; D014019:Tissue Donors / Q000523:psychology*; D020858:Tissue and Organ Harvesting / Q000009:adverse effects* / Q000379:methods
references.citation: Lancet. 1999 Feb 13;353(9152):555
references.pmid: 10028986
references.citation: Blood. 1996 Oct 15;88(8):2819-25
references.pmid: 8874177
references.citation: Haematologica. 2006 May;91(5 Suppl):ECR08
references.pmid: 16709516
references.citation: Bone Marrow Transplant. 2008 Apr;41(8):687-705
references.pmid: 18084334
references.citation: Biol Blood Marrow Transplant. 2008 Sep;14(9 Suppl):29-36
references.pmid: 18721778
references.citation: Bone Marrow Transplant. 2003 Nov;32(9):873-80
references.pmid: 14561987
references.citation: Blood. 2009 Apr 9;113(15):3604-11
references.pmid: 19190248
references.citation: Blood. 2001 May 1;97(9):2541-8
references.pmid: 11313239
references.citation: Bone Marrow Transplant. 2002 Mar;29(6):479-86
references.pmid: 11960266
references.citation: Bone Marrow Transplant. 2003 Jun;31(11):1033-5
references.pmid: 12774056
references.citation: Transfusion. 2004 Aug;44(8):1260-1
references.pmid: 15265137
references.citation: J Clin Oncol. 2009 Jan 10;27(2):256-63
references.pmid: 19064984
references.citation: Cochrane Database Syst Rev. 2009 Jan 21;(1):CD006406
references.pmid: 19160282
references.citation: Biol Blood Marrow Transplant. 2002;8(5):257-60
references.pmid: 12064362
references.citation: Bone Marrow Transplant. 2008 Jul;42(1):61-2
references.pmid: 18362903
references.citation: Bone Marrow Transplant. 1996 Mar;17 Suppl 2:S28-30
references.pmid: 8722330
references.citation: Bone Marrow Transplant. 2001 May;27(9):917-23
references.pmid: 11436101
references.citation: Bone Marrow Transplant. 2002 Jan;29(2):145-9
references.pmid: 11850709
references.citation: Transfusion. 2008 Jul;48(7):1495-501
references.pmid: 18373639
references.citation: Biol Blood Marrow Transplant. 2004 Jun;10(6):405-14
references.pmid: 15148494
references.citation: J Pediatr Hematol Oncol. 2004 Nov;26(11):761-3
references.pmid: 15543014
references.citation: Hematology Am Soc Hematol Educ Program. 2005;:469-75
references.pmid: 16304422
references.citation: Haematologica. 2008 May;93(5):735-40
references.pmid: 18387976
references.citation: Blood. 2006 Dec 15;108(13):4288-90
references.pmid: 16946302
references.citation: Biol Blood Marrow Transplant. 2008 Sep;14(9 Suppl):16-22
references.pmid: 18721776
references.citation: Blood. 1984 Sep;64(3):630-4
references.pmid: 6380620
references.citation: Exp Hematol. 2004 Jan;32(1):122-30
references.pmid: 14725909
references.citation: Blood. 2000 Apr 1;95(7):2219-25
references.pmid: 10733488
references.citation: Bone Marrow Transplant. 2004 Jul;34(2):103-10
references.pmid: 15170173
references.citation: Haematologica. 2009 Jan;94(1):94-101
references.pmid: 19059940
references.citation: Bone Marrow Transplant. 2007 Jan;39(2):71-87
references.pmid: 17213849