Supplementation with magnesium and vitamin E were more effective than magnesium alone to decrease plasma lipids and blood viscosity in diabetic rats.
Although magnesium and vitamin E (VE) have differing effects on diabetes, both are beneficial. We hypothesized that preventive supplementation of magnesium combined with VE could improve the metabolism of lipids and blood viscosity more effectively than the use of magnesium or VE alone. Our objective was to detect the effects of preventive supplementation of magnesium combined with VE on lipid peroxidation, lipid metabolic parameters, and blood viscosity in diabetic rats. Six dietary groups, all fed with high-energy diets, were formed and studied for 8 weeks: control group (C); VE group (E); middle-dose magnesium group (MM); high-dose magnesium group (HM); VE plus middle-dose magnesium group (EMM); and VE plus high-dose magnesium group (EHM). Compared with C group, malondialdehyde was inhibited in the E, EMM, and EHM groups (all P < .05); total cholesterol decreased in all 5 treated groups, and significant differences were found in groups E (P = .004), MM (P = .017), EMM (P = .016), and EHM (P = .020). Compared with the C group, high-density lipoprotein levels were elevated in the HM (P = .027) and EHM (P = .021) groups, and low-density lipoprotein levels were lower in the E (P = .010), EMM (P = .025), and EHM (P = .015) groups. Differences between middle and high shear rates of blood viscosity were significant in all treated groups compared with the C group (all P <or= .001). Statistical analysis showed that there was no interaction between magnesium and VE. We concluded that preventive supplementation of VE combined with magnesium was more beneficial to improve the plasma lipid parameters and blood viscosity in diabetic rats than magnesium alone.
Dou
Mei
M
Department of Marine Biology, Ocean University of China, Qingdao, PR China.
Ma
Ai Guo
AG
Wang
Qiu Zhen
QZ
Liang
Hui
H
Li
Yong
Y
Yi
Xue Mei
XM
Zhang
Shi Cui
SC
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001809:Blood Viscosity / Q000187:drug effects*; D002784:Cholesterol / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy*; D004032:Diet; D019587:Dietary Supplements; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D005260:Female; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D008055:Lipids / Q000097:blood*; D008274:Magnesium / Q000494:pharmacology*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D051381:Rats; D017208:Rats, Wistar; D014810:Vitamin E / Q000494:pharmacology*
D000975:Antioxidants; D000960:Hypolipidemic Agents; D008055:Lipids; D014810:Vitamin E; D008315:Malondialdehyde; D002784:Cholesterol; D008274:Magnesium