title: Insulin resistance and secretion indexes in healthy Italian children and adolescents: a multicentre study.
abstract: OBJECTIVE
  To establish normal values of insulin resistance, secretion and sensitivity using respectively HOMA-IR, HOMA-beta% and QUICKI indexes in healthy Italian children and adolescents, based on fasting samples.
  
  
  METHODS
  We determined HOMA-IR, HOMA-beta% and QUICKI at baseline in 142 healthy subjects from Pediatric Centres, aged 2.7 to 19 years (10.6 +/- 3.8, Mean +/- SD), with different Tanner's pubertal Stages (TS). None had hypo/hyperglycemia (fasting plasma glucose ranging from 3.6 to 5.6 mmol/l), obesity (BMI (kg/m2) 17.9 +/- 2.4, M +/- SD), or family history for diabetes mellitus.
  
  
  RESULTS
  The HOMA-IR index slightly increases with Tanner's stage. As regards HOMA-beta% and QUICKI, a weak variation throughout puberty was observed. No significant correlation was observed between HOMA-IR, HOM A-beta%, QUICKI and BMI-SDS or chronologic age.
  
  
  CONCLUSIONS
  Normal values of HOMA-IR, HOMA-beta% and QUICKI are useful tools in the clinical and epidemiological practice for baseline screening and follow-up of subjects at risk for type 2 diabetes mellitus.
authors.affiliation: Pediatric Clinic, University of Genoa, Italy. giuseppedannunzio@ospedale-gaslini.ge.it
authors.forename: Giuseppe
authors.initials: G
authors.lastname: d'Annunzio
authors.forename: Maurizio
authors.initials: M
authors.lastname: Vanelli
authors.forename: Angela
authors.initials: A
authors.lastname: Pistorio
authors.forename: Nicola
authors.initials: N
authors.lastname: Minuto
authors.forename: Laura
authors.initials: L
authors.lastname: Bergamino
authors.forename: Dario
authors.initials: D
authors.lastname: Iafusco
authors.forename: Renata
authors.initials: R
authors.lastname: Lorini
mesh_terms: D000293:Adolescent; D000367:Age Factors; D001786:Blood Glucose / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005215:Fasting / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance / Q000208:ethnology / Q000502:physiology*; D050417:Insulin-Secreting Cells / Q000502:physiology; D007558:Italy; D011627:Puberty / Q000378:metabolism; D012016:Reference Values; D015203:Reproducibility of Results; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D007328:Insulin