Paramyxovirus disruption of interferon signal transduction: STATus report.
RNA viruses in the paramyxovirus family have evolved a number of strategies to escape host cell surveillance and antiviral responses. One mechanism exploited by a number of viruses in this family is direct targeting of cytokine-inducible transcription regulators in the STAT family. Diverse members of this large virus family effectively suppress STAT signaling by the actions of their V proteins, or the related proteins derived from alternate viral mRNAs. These viral proteins have distinct means of targeting STATs, resulting in a variety of negative effects on STATs and their signal transduction. Recent developments in understanding STAT targeting will be reviewed.
Ramachandran
Aparna
A
Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Evanston, Illinois 60208, USA.
Horvath
Curt M
CM
D000818:Animals; D015536:Down-Regulation; D006801:Humans; D007113:Immunity, Innate; D007372:Interferons / Q000276:immunology*; D010252:Paramyxoviridae / Q000276:immunology* / Q000472:pathogenicity; D018184:Paramyxoviridae Infections / Q000235:genetics / Q000276:immunology* / Q000821:virology*; D050791:STAT Transcription Factors / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D014764:Viral Proteins / Q000276:immunology / Q000378:metabolism
D050791:STAT Transcription Factors; C502891:V protein, Paramyxovirus; D014764:Viral Proteins; D007372:Interferons
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