Signaling via Histidine-Containing Phosphotransfer Proteins in Arabidopsis.
The Arabidopsis genome encodes a number of proteins with similarity to two-component phosphorelay signaling elements, including hybrid receptor histidine kinases, two classes of response regulator proteins (type-A and type-B ARRs) and a family of six histidine-containing phosphotransfer proteins (AHPs), five of which contain a conserved His residue that is required for phosphorelay signaling. The current model for cytokinin signaling includes a multistep phosphorelay: three histidine kinases and at least five type-B ARRs have been shown to act as positive regulators of cytokinin signaling, while a number of type-A ARRs, and AHP6, act as negative regulators of the pathway. In our recent Plant Cell paper, we provided genetic evidence that at least four AHPs can act as positive regulators of cytokinin signaling, affecting responses to cytokinin in the root and the shoot. In this addendum, we discuss the role of AHPs in cytokinin signaling and speculate on their potential interactions with other signaling pathways in Arabidopsis.
Hutchison
Claire E
CE
Department of Biology; University of North Carolina; Chapel Hill, North Carolina USA.
Kieber
Joseph J
JJ
Plant Cell. 2006 Jan;18(1):55-69
16326927
Plant Cell. 2006 Jan;18(1):40-54
16361392
Plant Cell. 2004 Jun;16(6):1365-77
15155880
Plant Cell Physiol. 1998 Dec;39(12):1258-68
10050311
Mol Genet Genomics. 2003 Jul;269(4):443-53
12774227
Plant Cell Physiol. 2001 Sep;42(9):1017-23
11577198
Plant Cell Physiol. 2007 Jan;48(1):84-96
17132632
Plant Cell. 2005 Nov;17(11):3007-18
16227453
Plant Physiol. 2004 Oct;136(2):2913-20
15466220
Proc Natl Acad Sci U S A. 2004 Jun 8;101(23):8821-6
15166290
Proc Natl Acad Sci U S A. 2006 Jul 18;103(29):11081-5
16832061
Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15800-5
12426401
Plant Cell Physiol. 2001 Jan;42(1):37-45
11158442
Annu Rev Plant Physiol Plant Mol Biol. 2001 Jun;52:89-118
11337393
FEBS Lett. 2004 Jan 30;558(1-3):85-8
14759521
Plant Cell Physiol. 2007 Feb;48(2):375-80
17202180
Plant Cell Physiol. 2004 Sep;45(9):1299-305
15509853
J Bacteriol. 2007 Jan;189(2):325-35
17071758
Science. 2006 Jan 6;311(5757):94-8
16400151
Trends Microbiol. 1999 Mar;7(3):115-20
10203840
Nature. 2001 Sep 27;413(6854):383-9
11574878
Plant Cell. 1999 Sep;11(9):1743-54
10488240
Plant Cell Physiol. 2002 Jan;43(1):123-9
11828030
Biosci Biotechnol Biochem. 2004 Feb;68(2):462-5
14981318
Plant Cell. 2004 Mar;16(3):658-71
14973166
Plant Physiol. 2004 Oct;136(2):2961-70
15466228
Nature. 2001 Feb 22;409(6823):1060-3
11234017
FEBS Lett. 2000 Aug 4;478(3):227-32
10930573
Nature. 2005 Dec 22;438(7071):1172-5
16372013