Schiff bases as potential fungicides and nitrification inhibitors.
A number of substituted Schiff bases were synthesized and characterized by (1)H NMR and mass spectrometry. These compounds were screened for antifungal activity in vitro against pathogenic fungi, namely, Sclerotium rolfsii and Rhizoctonia bataticola, and for their effect on nitrification inhibition under laboratory conditions. Maximum antifungal activity was exhibited by (2,4-dichlorobenzylidene)-(2,4,5-trichlorophenyl)-amine and (3-nitrobenzylidene)-(2,4,5-trichlorophenyl)-amine against both fungi (ED(50) with range from 3 to 24 microg/mL). Maximum nitrification inhibition (NI) was exhibited by (2,4-dichlorobenzylidene)-(2-fluorophenyl)-amine, (4-fluorophenyl)-(3-nitrobenzylidene)-amine, (2,6-dichlorobenzylidene)-(4-fluorophenyl)-amine, and (2,6-dichlorobenzylidene)-(3 fluorophenyl)-amine (NI in the range 91-96%).
Aggarwal
Nisha
N
Department of Chemistry, University of Delhi, Delhi 110 007, India.
Kumar
Rajesh
R
Dureja
Prem
P
Rawat
Diwan S
DS
D001203:Ascomycota / Q000187:drug effects; D005659:Fungicides, Industrial / Q000494:pharmacology*; D007097:Imines / Q000138:chemical synthesis / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D009566:Nitrates / Q000032:analysis; D009573:Nitrites / Q000032:analysis; D009584:Nitrogen / Q000032:analysis*; D000644:Quaternary Ammonium Compounds / Q000032:analysis; D012232:Rhizoctonia / Q000187:drug effects; D012545:Schiff Bases / Q000138:chemical synthesis / Q000494:pharmacology*; D012987:Soil / Q000032:analysis*
D005659:Fungicides, Industrial; D007097:Imines; D009566:Nitrates; D009573:Nitrites; D000644:Quaternary Ammonium Compounds; D012545:Schiff Bases; D012987:Soil; D009584:Nitrogen