title: An M-CSF receptor c-Fms antibody inhibits mechanical stress-induced root resorption during orthodontic tooth movement in mice.
abstract: OBJECTIVE
  To examine the effect of anti-c-Fms antibody on odontoclastogenesis and root resorption in an orthodontic tooth movement mouse model.
  
  
  METHODS
  We used orthodontic tooth movement in which an Ni-Ti coil spring was inserted between the upper incisors and the upper first molar. Root resorption occurred in this model. Anti-c-Fms antibody was injected daily into a local site for 12 days during mechanical loading. Odontoclastogenesis and root resorption were assessed by histology and scanning electron microscopy.
  
  
  RESULTS
  The anti-c-Fms antibody significantly inhibited odontoclastogenesis and root resorption during orthodontic tooth movement.
  
  
  CONCLUSIONS
  M-CSF and/or its receptor is a potential therapeutic target in mechanical stress- induced odontoclastogenesis, and injection of an anti-c-Fms antibody might be useful for inhibition of mechanical stress-induced root resorption during orthodontic tooth movement.
authors.affiliation: Divisions of Orthodontic and Dentofacial Orthopedics, Department of Translational Medicine, Course of Medical and Dental Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan. kitaura@net.nagasaki-u.ac.jp
authors.forename: Hideki
authors.initials: H
authors.lastname: Kitaura
authors.forename: Yuji
authors.initials: Y
authors.lastname: Fujimura
authors.forename: Masako
authors.initials: M
authors.lastname: Yoshimatsu
authors.forename: Toshiko
authors.initials: T
authors.lastname: Eguchi
authors.forename: Haruka
authors.initials: H
authors.lastname: Kohara
authors.forename: Insan
authors.initials: I
authors.lastname: Jang
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Morita
authors.forename: Noriaki
authors.initials: N
authors.lastname: Yoshida
mesh_terms: D016301:Alveolar Bone Loss / Q000209:etiology / Q000517:prevention & control; D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology* / Q000627:therapeutic use; D003799:Dental Stress Analysis; D007074:Immunoglobulin G / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010010:Osteoclasts / Q000187:drug effects*; D016186:Receptor, Macrophage Colony-Stimulating Factor / Q000037:antagonists & inhibitors*; D012391:Root Resorption / Q000209:etiology / Q000517:prevention & control*; D014087:Tooth Movement Techniques / Q000009:adverse effects*
chemical_list: D000911:Antibodies, Monoclonal; D007074:Immunoglobulin G; D016186:Receptor, Macrophage Colony-Stimulating Factor