Differential-absorption photoacoustic imaging.
We present differential-absorption photoacoustic imaging, which detects the difference between transient and ground-state absorption, for contrast enhancement based on suppressing undesired objects. Two tubes were imaged. One contains a Pt(II) octaethylporphine (PtOEP) dye solution and serves as an object of interest, while the other contains an IR-783 (from Sigma-Aldrich) dye solution and serves as an object to suppress. Although the IR-783 tube dominates the conventional photoacoustic image, it is suppressed by 43 dB and consequently significantly overwhelmed by the PtOEP tube in the differential-absorption photoacoustic image. Imaging depth in this mode is also discussed.
Huang
Sheng-Wen
SW
Department of Bioengineering, University of Washington, 1705 NE Pacific Street, Seattle, Washington 98195, USA. shengwen@u.washington.edu
Eary
Janet F
JF
Jia
Congxian
C
Huang
Lingyun
L
Ashkenazi
Shai
S
O'Donnell
Matthew
M
D000042:Absorption; D000162:Acoustics; D004396:Coloring Agents; D008027:Light; D057054:Molecular Imaging / Q000379:methods*; D009942:Organometallic Compounds
D004396:Coloring Agents; D009942:Organometallic Compounds