Mechanisms of evasion of the type I interferon antiviral response by flaviviruses.
Virus survival and the ability to cause disease in mammalian hosts depend on their ability to avoid recognition and control by the interferon signal transduction and effector pathways. Flaviviruses comprise a large family of nonsegmented positive sense enveloped cytoplasmic RNA viruses, many of which are globally important human pathogens. Although the mechanistic details are still being dissected, new insight has emerged as to how a flavivirus minimizes the antiviral activity of type I interferon (IFN) to establish productive and potentially lethal infection. This review will summarize our current understanding of how mammalian cells recognize flaviviruses to induce an inhibitory IFN response and the countermeasures this group of viruses has evolved to antagonize this response.
Diamond
Michael S
MS
Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA. diamond@borcim.wustl.edu
D000818:Animals; D005416:Flavivirus / Q000276:immunology* / Q000472:pathogenicity; D018177:Flavivirus Infections / Q000235:genetics / Q000276:immunology* / Q000635:transmission / Q000821:virology*; D005786:Gene Expression Regulation; D006801:Humans; D007113:Immunity, Innate; D050835:Interferon Regulatory Factors / Q000378:metabolism; D007370:Interferon Type I / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000378:metabolism; D011956:Receptors, Cell Surface; D050791:STAT Transcription Factors / Q000378:metabolism; D015398:Signal Transduction; D051193:Toll-Like Receptors / Q000378:metabolism; D017361:Viral Nonstructural Proteins / Q000276:immunology / Q000378:metabolism*; D014774:Virulence; D000097905:Roundabout Proteins
D050835:Interferon Regulatory Factors; D007370:Interferon Type I; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D011956:Receptors, Cell Surface; D050791:STAT Transcription Factors; D051193:Toll-Like Receptors; D017361:Viral Nonstructural Proteins; C118348:Robo3 protein, mouse; D000097905:Roundabout Proteins