title: TPH2 polymorphisms may modify clinical picture in treatment-resistant depression.
abstract: The association of two tryptophan hydroxylase 2 (TPH2) polymorphisms and treatment response in electroconvulsive therapy (ECT) and the risk of depression was studied. The patient sample consisted of 119 subjects with treatment-resistant major depressive disorder who were treated with ECT. Treatment response was assessed by the Montgomery and Asberg Depression Rating Scale (MADRS) scores. Patients who had <8 scores in post-treatment MADRS were considered remitters; scores >15 indicated non-response. The polymorphisms studied (rs1386494 and rs1843809) were not associated with treatment response to ECT. However, TPH2 rs1386494 A/A genotype carrying patients had significantly higher MADRS scores before ECT than A/G+G/G genotype carriers (p<0.001). A/A genotype carriers also had a greater decline in MADRS scores than A/G+G/G genotype carriers during the course of ECT treatment (p=0.03). This polymorphism may be associated with the severity of treatment-resistant depression. ECT may able to counteract a putative genetically driven worse depressive phenotype.
authors.affiliation: University of Tampere, Medical School, 33014 University of Tampere, Finland.
authors.forename: Sami
authors.initials: S
authors.lastname: Anttila
authors.forename: Merja
authors.initials: M
authors.lastname: Viikki
authors.forename: Kaija
authors.initials: K
authors.lastname: Huuhka
authors.forename: Martti
authors.initials: M
authors.lastname: Huuhka
authors.forename: Heini
authors.initials: H
authors.lastname: Huhtala
authors.forename: Riikka
authors.initials: R
authors.lastname: Rontu
authors.forename: Terho
authors.initials: T
authors.lastname: Lehtimäki
authors.forename: Esa
authors.initials: E
authors.lastname: Leinonen
mesh_terms: D003865:Major Depressive Disorder / Q000235:genetics* / Q000628:therapy; D004565:Electroconvulsive Therapy; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D014365:Tryptophan Hydroxylase / Q000235:genetics*
chemical_list: C494784:TPH2 protein, human; D014365:Tryptophan Hydroxylase