Daunorubicin and doxorubicin inhibit the [(11)C]choline accumulation in cancer cells.
We studied how very short (10-40min) incubation with anthracycline derivatives modifies the accumulation of PET tumor-diagnostic radiotracers in cancer cells. The human ovarian A2780 and A2780AD, human B lymphoid JY, human epidermoid KB-3-1 and KB-V-1, and smooth muscle DDT1 MF-2 cells were pre-incubated with daunorubicin and doxorubicin, and the uptake of [(18)F]FDG and [(11)C]choline was measured. Anthracycline treatment decreased remarkably the [(11)C]choline accumulation in a concentration dependent manner, while it did not modify significantly the [(18)F]FDG uptake of the cells.
Mikecz
Pál
P
Department of Nuclear Medicine, University of Debrecen, Medical and Health Science Centre, Debrecen, Hungary. pal@pet.dote.hu
Márián
Teréz
T
Miklovicz
Tünde
T
Galuska
László
L
Krasznai
Zoltán
Z
Tóth
Agnes
A
Goda
Katalin
K
Trón
Lajos
L
Hernádi
Zoltán
Z
Krasznai
Zoárd T
ZT
D002250:Carbon Radioisotopes; D045744:Cell Line, Tumor; D002794:Choline / Q000378:metabolism*; D003630:Daunorubicin / Q000494:pharmacology*; D004317:Doxorubicin / Q000494:pharmacology*; D019788:Fluorodeoxyglucose F18; D006801:Humans
D002250:Carbon Radioisotopes; D019788:Fluorodeoxyglucose F18; D004317:Doxorubicin; D002794:Choline; D003630:Daunorubicin