title: Macrophage metalloelastase: stretching therapeutic opportunities.
abstract: While tissue macrophages are at the first line of microbial host defense, they are also convenient hideouts for pathogens escaping immune attack. Houghton et al. discovered that alveolar macrophage mobilizes macrophage metalloelastase to destroy bacteria present inside the cell.
authors.affiliation: Department of Immunology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
authors.forename: Jeannie Q
authors.initials: JQ
authors.lastname: He
authors.affiliation: Department of Immunology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA. menno@gene.com
authors.forename: Menno
authors.initials: M
authors.lastname: van Lookeren Campagne
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000378:metabolism*; D001419:Bacteria / Q000166:cytology / Q000187:drug effects; D006801:Humans; D008247:Lysosomes / Q000187:drug effects / Q000382:microbiology; D008264:Macrophages / Q000166:cytology / Q000187:drug effects / Q000201:enzymology; D053508:Matrix Metalloproteinase 12 / Q000378:metabolism*; D050296:Microbial Viability / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D053508:Matrix Metalloproteinase 12