Viscerotropic disease following yellow fever vaccination in Peru.
Five suspected cases of yellow fever vaccine-associated viscerotropic disease (YEL-AVD) clustered in space and time following a vaccination campaign in Ica, Peru in 2007. All five people received the same lot of 17DD live attenuated yellow fever vaccine before their illness; four of the five died of confirmed YEL-AVD. The surviving case was classified as probable YEL-AVD. Intensive investigation yielded no abnormalities of the implicated vaccine lot and no common risk factors. This is the first described space-time cluster of yellow fever viscerotropic disease involving more than two cases. Mass yellow fever vaccination should be avoided in areas that present extremely low risk of yellow fever.
Whittembury
Alvaro
A
Ministerio de Salud, Lima, Peru.
Ramirez
Gladys
G
Hernández
Herminio
H
Ropero
Alba Maria
AM
Waterman
Steve
S
Ticona
María
M
Brinton
Margo
M
Uchuya
Jorge
J
Gershman
Mark
M
Toledo
Washington
W
Staples
Erin
E
Campos
Clarense
C
Martínez
Mario
M
Chang
Gwong-Jen J
GJ
Cabezas
Cesar
C
Lanciotti
Robert
R
Zaki
Sherif
S
Montgomery
Joel M
JM
Monath
Thomas
T
Hayes
Edward
E
D000328:Adult; D000368:Aged; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010568:Peru; D012307:Risk Factors; D014611:Vaccination / Q000009:adverse effects*; D014613:Vaccines, Attenuated / Q000009:adverse effects; D015004:Yellow Fever / Q000517:prevention & control*; D022341:Yellow Fever Vaccine / Q000009:adverse effects*; D055815:Young Adult
D014613:Vaccines, Attenuated; D022341:Yellow Fever Vaccine