title: Hearing sensitivity in women following chemotherapy treatment for breast cancer: results from a pilot study.
abstract: OBJECTIVE
  Our aim was to examine in a prospective pilot study whether standard adjuvant treatments for breast cancer can adversely affect hearing.
  
  
  METHODS
  Eight pre/peri-menopausal women with breast cancer had middle ear analysis (tympanometry) and pure tone audiometry conducted prior to and 6 months following Fluorouracil, Epirubicin, Cyclophosphamide (FEC) or FEC plus taxotere chemotherapy treatments.
  
  
  RESULTS
  The mean hearing thresholds in both ears showed an elevation (that is a decline) post chemotherapy treatment at 6 and 8kHz of between 20 and 30dB, which is graded as a mild hearing impairment at the higher frequency range. There were individual differences in pattern and grade within the group.
  
  
  CONCLUSIONS
  The variability noted in the data is more than that would be anticipated for test-retest variance, suggesting that the hearing impairments are complex but genuine. The most likely cause of the reduction in hearing sensitivity is a change in oestrogen levels resulting from the breast cancer treatments.
authors.affiliation: Cancer Research UK Psychosocial Oncology Group, Brighton and Sussex Medical School, University of Sussex, Brighton, UK. val@sussex.ac.uk
authors.forename: V
authors.initials: V
authors.lastname: Jenkins
authors.forename: R
authors.initials: R
authors.lastname: Low
authors.forename: S
authors.initials: S
authors.lastname: Mitra
mesh_terms: D000158:Acoustic Impedance Tests; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001301:Audiometry, Pure-Tone; D001943:Breast Neoplasms / Q000097:blood / Q000188:drug therapy*; D003520:Cyclophosphamide / Q000627:therapeutic use; D015251:Epirubicin / Q000627:therapeutic use; D004958:Estradiol / Q000097:blood; D004967:Estrogens / Q000502:physiology; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use; D006309:Hearing / Q000502:physiology*; D006319:Hearing Loss, Sensorineural / Q000503:physiopathology; D006801:Humans; D008875:Middle Aged; D038781:Otoscopy; D010865:Pilot Projects; D011446:Prospective Studies; D013237:Stereoisomerism
chemical_list: D004967:Estrogens; D015251:Epirubicin; D004958:Estradiol; D003520:Cyclophosphamide; D005472:Fluorouracil