Multitargeted tyrosine kinase inhibitor stimulates expression of IL-6 and activates JAK2/STAT5 signaling in acute myelogenous leukemia cells.
Nishioka
C
C
Ikezoe
T
T
Yang
J
J
Yokoyama
A
A
D045744:Cell Line, Tumor; D016503:Drug Delivery Systems / Q000379:methods; D006801:Humans; D015850:Interleukin-6 / Q000096:biosynthesis; D053614:Janus Kinase 2 / Q000378:metabolism; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy* / Q000378:metabolism; D047428:Protein Kinase Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors*; D050799:STAT5 Transcription Factor / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects
D015850:Interleukin-6; D047428:Protein Kinase Inhibitors; D050799:STAT5 Transcription Factor; D011505:Protein-Tyrosine Kinases; D053614:Janus Kinase 2