Caenorhabditis elegans BAH-1 is a DUF23 protein expressed in seam cells and required for microbial biofilm binding to the cuticle.
The cuticle of Caenorhabditis elegans, a complex, multi-layered extracellular matrix, is a major interface between the animal and its environment. Biofilms produced by the bacterial genus Yersinia attach to the cuticle of the worm, providing an assay for surface characteristics. A C. elegans gene required for biofilm attachment, bah-1, encodes a protein containing the domain of unknown function DUF23. The DUF23 domain is found in 61 predicted proteins in C. elegans, which can be divided into three distinct phylogenetic clades. bah-1 is expressed in seam cells, which are among the hypodermal cells that synthesize the cuticle, and is regulated by a TGF-beta signaling pathway.
Drace
Kevin
K
Department of Cell and Tissue Biology, Program in Microbial Pathogenesis and Host Defense, University of California San Francisco, San Francisco, California, USA. drace_km@mercer.edu
McLaughlin
Stephanie
S
Darby
Creg
C
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D018441:Biofilms; D017173:Caenorhabditis elegans / Q000235:genetics / Q000378:metabolism*; D029742:Caenorhabditis elegans Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D017931:DNA Primers; D005455:Fluorescent Antibody Technique; D008969:Molecular Sequence Data; D010802:Phylogeny; D034622:RNA Interference; D020133:Reverse Transcriptase Polymerase Chain Reaction; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction; D016212:Transforming Growth Factor beta / Q000378:metabolism
D029742:Caenorhabditis elegans Proteins; D017931:DNA Primers; D016212:Transforming Growth Factor beta
Genetics. 1993 Aug;134(4):1105-17
8375650
WormBook. 2007 Mar 19;:1-15
18050497
Microbiology (Reading). 2003 Nov;149(Pt 11):3221-3229
14600234
Science. 2001 Sep 14;293(5537):2087-92
11557892
Appl Environ Microbiol. 2008 Jul;74(14):4509-15
18515487
J Cell Biol. 1981 Jul;90(1):7-17
7251677
J Biol Chem. 2004 Dec 17;279(51):52893-903
15452127
Nature. 2002 May 16;417(6886):243-4
12015591
Proc Natl Acad Sci U S A. 1990 Apr;87(8):2901-5
1691498
Nucleic Acids Res. 2001 Jan 1;29(1):82-6
11125056
Dev Biol. 2005 Jun 1;282(1):231-45
15936343
Dev Biol. 2000 Jan 1;217(1):192-204
10625546
WormBook. 2007 Aug 08;:1-19
17988074
Genes Brain Behav. 2007 Apr;6(3):240-52
16879619
J Bacteriol. 2004 Aug;186(15):5087-92
15262945
Proc Natl Acad Sci U S A. 1996 Oct 29;93(22):12388-93
8901591
Nature. 1996 Jul 18;382(6588):268-72
8717044
Methods. 2003 Aug;30(4):313-21
12828945
WormBook. 2006 Oct 25;:1-29
18050433
Curr Biol. 2002 Sep 17;12(18):1566-73
12372248
Parasitology. 1993 Jul;107 ( Pt 1):107-17
8355993
Nat Protoc. 2007;2(4):953-71
17446895
Genetics. 2007 Feb;175(2):681-97
17151260
Genetics. 2005 Nov;171(3):1033-45
16079230
Genetics. 1998 Sep;150(1):129-55
9725835
BMC Dev Biol. 2004 Sep 20;4:11
15380030
Infect Immun. 2005 Nov;73(11):7236-42
16239518
J Cell Biol. 1991 Dec;115(5):1237-47
1955471
Nature. 1993 Dec 2;366(6454):461-4
8247153
PLoS Biol. 2005 Oct;3(10):e312
16122351
Mol Biochem Parasitol. 1994 May;65(1):147-59
7935621
Nucleic Acids Res. 2006 Jan 1;34(Database issue):D247-51
16381856
Genetics. 1992 Aug;131(4):867-81
1516818
Nucleic Acids Res. 2008 Jan;36(Database issue):D281-8
18039703
Genetics. 1992 Jan;130(1):105-23
1732156
J Infect Dis. 2004 Aug 15;190(4):783-92
15272407
Genetics. 1987 Nov;117(3):467-76
3692138
J Biol Chem. 2004 Jul 16;279(29):30440-8
15123614
Genetics. 2007 May;176(1):221-30
17339204
WormBook. 2005 Sep 09;:1-12
18050404
Mol Biol Evol. 2007 Aug;24(8):1596-9
17488738
Exp Parasitol. 1992 Aug;75(1):72-86
1639165
Aging Cell. 2003 Apr;2(2):111-21
12882324
Curr Biol. 2006 Jan 10;16(1):89-94
16401427
Protein Sci. 2003 Jul;12(7):1418-31
12824488
J Biol Chem. 1993 Mar 25;268(9):6600-9
8503957
Mol Cell Biol. 1985 Feb;5(2):363-72
2983191
Nucleic Acids Res. 2007 Jul;35(Web Server issue):W585-7
17517783