title: Association between nonalcoholic fatty liver disease and coronary artery calcification.
abstract: BACKGROUND
  Both nonalcoholic fatty liver disease (NAFLD) and coronary artery disease (CAD) are closely related to many metabolic disorders. Multislice computed tomography (MSCT) is a reliable noninvasive method in demonstrating coronary plaque. However, the association between coronary artery calcium (CAC) score and NAFLD remains controversial.
  
  
  OBJECTIVE
  The aim of this study is to evaluate the association between CAC score and NAFLD.
  
  
  METHODS
  This retrospective study enrolled 295 consecutive asymptomatic subjects who had both coronary angiography by MSCT and hepatobiliary imaging during self-paid physical check-ups.
  
  
  RESULTS
  NAFLD was found in 41% of the enrolled 295 subjects; gall bladder stones were found in 10.8%, and CAC > 100 with moderate-high risk of CAD was found in 12.9% of subjects. Male gender (odds ratios (OR), 3.087; 95% confidence intervals (CI), 1.092-8.729), increased age (OR, 1.108; 95% CI, 1.067-1.151), diabetes mellitus (DM) (OR, 2.968; 95% CI, 1.129-7.803), and NAFLD (OR, 2.462; 95% CI, 1.065-5.691) were the independent factors that increased the risk of CAC > 100 in binary logistic regression. The prevalence of NAFLD also increased with the severity of CAC score (<or=100, 38.1%; 101-400, 58.3%; >400, 64.3%; P = 0.03).
  
  
  CONCLUSIONS
  Besides the traditional risk factors, such as male gender, increased age, and DM, NAFLD was also associated with moderate to high risk of CAD (CAC > 100).
authors.affiliation: Digestive Disease Center, Changhua Show-Chwan Memorial Hospital, Section 1, Changhua, Taiwan. peach@show.org.tw
authors.forename: Chien-Hua
authors.initials: CH
authors.lastname: Chen
authors.forename: Chiu-Kue
authors.initials: CK
authors.lastname: Nien
authors.forename: Chi-Chieh
authors.initials: CC
authors.lastname: Yang
authors.forename: Yung-Hsiang
authors.initials: YH
authors.lastname: Yeh
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002114:Calcinosis / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000209:etiology*; D016009:Chi-Square Distribution; D017023:Coronary Angiography / Q000379:methods; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000209:etiology*; D003920:Diabetes Mellitus / Q000453:epidemiology; D005234:Fatty Liver / Q000150:complications* / Q000000981:diagnostic imaging / Q000453:epidemiology; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D012720:Severity of Illness Index; D012737:Sex Factors; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography
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