title: Plasmapheresis treatment of antibody-mediated rejection in an A2 donor to O pediatric liver transplant recipient.
abstract: It is safe to transplant kidneys from blood group A2 donors into O recipients if the latter have low titers of anti-A antibodies. However, in liver transplantation, O and B recipients of A2 donor livers are not routinely screened for anti-blood group antibodies because of the immuno-absorptive capacity of the liver and the low incidence of antibody-mediated rejection. Herein, we report a rare case of combined cell and antibody-mediated rejection in a pediatric blood group O recipient of an A2 donor liver, and rescue of the allograft using PP and IVIG.
authors.affiliation: Division of GI/Hepatology and Liver Transplantation, Department of Pediatrics, University of Utah Hospital, Salt Lake City, UT 84113, USA. triscia.martin@hsc.utah.edu
authors.forename: T
authors.initials: T
authors.lastname: Martin
authors.forename: J
authors.initials: J
authors.lastname: Schwartz
authors.forename: A
authors.initials: A
authors.lastname: Demetris
authors.forename: J
authors.initials: J
authors.lastname: Comstock
authors.forename: A
authors.initials: A
authors.lastname: Lowichik
authors.forename: L
authors.initials: L
authors.lastname: Book
mesh_terms: D000293:Adolescent; D001706:Biopsy; D001787:Blood Group Incompatibility; D058625:End Stage Liver Disease / Q000628:therapy*; D005260:Female; D006084:Graft Rejection; D006801:Humans; D056724:Immunity, Humoral; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007223:Infant; D007249:Inflammation; D007511:Ischemia; D016031:Liver Transplantation / Q000379:methods*; D010956:Plasmapheresis / Q000379:methods*; D014184:Transplantation, Homologous / Q000379:methods
chemical_list: D007166:Immunosuppressive Agents