title: Regulation of neuron mitochondrial biogenesis and relevance to brain health.
abstract: Mitochondrial dysfunction has severe cellular consequences, and is linked to aging and neurological disorders in humans. Impaired energy supply or Ca(2+) buffering, increased ROS production, or control of apoptosis by mitochondria may contribute to the progressive decline of long-lived postmitotic cells. Mitochondrial biogenesis refers to the process via which cells increase their individual mitochondrial mass. Mitochondrial biogenesis may represent an attempt by cells to increase their aerobic set point, or an attempt to maintain a pre-existing aerobic set point in the face of declining mitochondrial function. Neuronal mitochondrial biogenesis itself has been poorly studied, but investigations from other tissues and model systems suggest a series of transcription factors, transcription co-activators, and signal transduction proteins should function to regulate mitochondrial number and mass within neurons. We review data pertinent to the mitochondrial biogenesis field, and discuss implications for brain aging and neurodegenerative disease research efforts.
authors.affiliation: Department of Neurology, University of Kansas School of Medicine, Kansas City, KS 66160, USA. ionyango@kumc.edu
authors.forename: Isaac G
authors.initials: IG
authors.lastname: Onyango
authors.forename: Jianghua
authors.initials: J
authors.lastname: Lu
authors.forename: Mariana
authors.initials: M
authors.lastname: Rodova
authors.forename: E
authors.initials: E
authors.lastname: Lezi
authors.forename: Adam B
authors.initials: AB
authors.lastname: Crafter
authors.forename: Russell H
authors.initials: RH
authors.lastname: Swerdlow
mesh_terms: D000375:Aging; D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D024101:Mitochondrial Proteins / Q000378:metabolism; D019636:Neurodegenerative Diseases / Q000378:metabolism; D009474:Neurons / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D024101:Mitochondrial Proteins; D017382:Reactive Oxygen Species