The effect of doxycycline on canine hip osteoarthritis: design of a 6-months clinical trial.
Twenty-five dogs were included in a randomized, double-blind trial to assess the efficacy of doxycycline (DOX) orally administered twice a day at 4 mg/kg/day (n = 12) for the treatment of osteoarthritis of the hip. Chondroitin sulfate (CS; 525 mg/day) was used as a positive control (n = 13). Dogs were re-examined monthly for 6 months after initiation of treatment. The assessment protocol included clinical score, radiographic findings and serum osteoarthritis biomarkers. Dogs treated with DOX showed statistically significant improvements (p < 0.05) in lameness, joint mobility, pain on palpation, weight-bearing and overall score at 2, 6, 4, 4 and 4 months, respectively, after treatment. Biomarker levels of CS-WF6 epitope and hyaluronan were significantly increased and decreased (p < 0.05) at 2 and 3 months after treatment compared to pretreatment. These results showed that DOX had a positive therapeutic effect in dogs with osteoarthritis.
Nganvongpanit
Korakot
K
Bone and Joint Research Laboratory, Department of Veterinary Biosciences and Public Health, Faculty of Veterinary Medicine, Chiang Mai University, Chiang Mai 50100, Thailand. korakot@chiangmai.ac.th
Pothacharoen
Peraphan
P
Suwankong
Niyada
N
Ong-Chai
Siriwan
S
Kongtawelert
Prachya
P
D000818:Animals; D015415:Biomarkers / Q000097:blood; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004318:Doxycycline / Q000627:therapeutic use*; D005260:Female; D006820:Hyaluronic Acid / Q000097:blood; D007596:Joints / Q000187:drug effects; D007794:Lameness, Animal / Q000188:drug therapy; D008297:Male; D015207:Osteoarthritis, Hip / Q000188:drug therapy / Q000662:veterinary*; D013997:Time Factors; D016896:Treatment Outcome
D015415:Biomarkers; D006820:Hyaluronic Acid; D004318:Doxycycline
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