Effect of estrogen replacement on the histologic response to polypropylene mesh implanted in the rabbit vagina model.
OBJECTIVE
The aim of this study was to determine the effect of estrogen replacement after ovariectomy on the histologic response to polypropylene mesh implanted in rabbit vagina.


METHODS
Thirty rabbits were assigned to 5 groups: sham laparotomy, ovariectomy, ovariectomy-preoperative estrogen, ovariectomy-postoperative estrogen, or ovariectomy-preoperative and postoperative estrogen. Rabbits underwent sham surgery or ovariectomy and were infused with vehicle or 17beta-estradiol (200 microg/d) for 4 weeks ("preoperative" estrogen). Polypropylene mesh was implanted in the posterior vaginal wall, and rabbits were infused with vehicle or "postoperative" estrogen for an additional 8 weeks. Grafts were harvested and underwent histologic evaluation.


RESULTS
Vaginal atrophy in ovariectomized rabbits was reversed by estrogen replacement. Scores for inflammation (P = .33) and neovascularization (P = .23) at the graft site were not different among estrogen replacement groups, but estrogen administration was associated with increased collagen deposition (P = .005).


CONCLUSIONS
Estrogen replacement administered for 8 weeks postoperatively increases collagen deposition into polypropylene mesh.
Higgins
Edmund W
EW
Department of Obstetrics and Gynecology, Scott & White Memorial Hospital and Clinic, Texas A&M University Health Science Center College of Medicine, Temple, TX, USA.
Rao
Arundhati
A
Baumann
Shannon S
SS
James
Rebecca L
RL
Kuehl
Thomas J
TJ
Muir
Tristi W
TW
Pierce
Lisa M
LM
D000818:Animals; D015914:Estrogen Replacement Therapy; D004967:Estrogens / Q000494:pharmacology; D005260:Female; D010052:Ovariectomy; D011126:Polypropylenes; D011817:Rabbits; D013526:Surgical Mesh; D014621:Vagina / Q000187:drug effects / Q000473:pathology* / Q000601:surgery*
D004967:Estrogens; D011126:Polypropylenes