title: "Primary" leptomeningeal medulloblastoma.
abstract: We report the case of an 8-year-old boy who presented with a 2-month history of headaches and mild visual impairment and was found to have a medulloblastoma with primary leptomeningeal involvement. No mass lesion was found on imaging studies, during subsequent intraoperative surgical inspection or at autopsy. The pathologic findings were first documented on cerebrospinal fluid cytologic examination and biopsy of the cerebellum and were later confirmed at necropsy. To our knowledge, this is the third reported case of medulloblastoma identified with primary leptomeningeal involvement without a cerebellar mass and the first such case with documented autopsy findings.
authors.affiliation: Department of Pathology and Laboratory Medicine (Section of Neuropathology), University of California, Los Angeles, CA 90024, USA. rmehta@mednet.ucla.edu
authors.forename: Rupal I
authors.initials: RI
authors.lastname: Mehta
authors.forename: Aaron R
authors.initials: AR
authors.lastname: Cutler
authors.forename: Joseph L
authors.initials: JL
authors.lastname: Lasky
authors.forename: William H
authors.initials: WH
authors.lastname: Yong
authors.forename: Jason T
authors.initials: JT
authors.lastname: Lerner
authors.forename: Brandon K
authors.initials: BK
authors.lastname: Hirota
authors.forename: Noriko
authors.initials: N
authors.lastname: Salamon
authors.forename: Gary W
authors.initials: GW
authors.lastname: Mathern
authors.forename: Harry V
authors.initials: HV
authors.lastname: Vinters
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002528:Cerebellar Neoplasms / Q000473:pathology* / Q000628:therapy; D002648:Child; D003131:Combined Modality Therapy; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008527:Medulloblastoma / Q000473:pathology* / Q000628:therapy; D008577:Meningeal Neoplasms / Q000473:pathology* / Q000628:therapy; D019635:Neurosurgical Procedures