Reproducible and persistent weakness in adult rats after surgical resection of motor cortex: evaluation with limb placement test.
OBJECTIVE
The purpose of this study was to develop a new rat model for surgical brain injury with motor weakness and to find an adequate behavior test for the application of the model.


METHODS
Thirty rats were divided into three groups: craniectomy (n = 10), durotomy (n = 10), and corticectomy (n = 10) groups. The coordinates of the three points from the bregma (coordinate A = +4,+1, B = -2,+1, and C = +4,+6). We evaluated right limb motor performance by the modified limb placement test and the cylinder test.


CONCLUSIONS
Persistent motor weakness was observed for 2 months in the corticectomy group by the limb placement test, whereas the cylinder test could not detect the weakness. We established a reproducible and persistent rat brain injury model and found that the modified limb placement test is sensitive enough to evaluate residual subtle weakness in this model.
Lee
Do-Hun
DH
Department of Neurosurgery, Seoul National University College of Medicine, 103 Daehang-no, Jongno-gu, Seoul 110-744, Korea.
Hong
Seok Ho
SH
Kim
Seung-Ki
SK
Lee
Chang-Sub
CS
Phi
Ji Hoon
JH
Cho
Byung-Kyu
BK
Wang
Kyu-Chang
KC
D000704:Analysis of Variance; D000818:Animals; D004195:Disease Models, Animal; D008297:Male; D009044:Motor Cortex / Q000293:injuries*; D009048:Motor Skills / Q000502:physiology*; D010291:Paresis / Q000209:etiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D020127:Recovery of Function; D015203:Reproducibility of Results; D045442:Rotarod Performance Test; D013997:Time Factors
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