miRNA regulation through ligand occupancy of a nuclear hormone receptor.
MicroRNAs (miRNAs) posttranscriptionally regulate gene expression, but the factors that direct transcription of miRNAs are not well characterized. Activation versus repression of key developmental miRNAs in Caenorhabditis elegans is directly mediated by ligand occupancy of a nuclear hormone receptor that acts to couple nutrient availability to developmental programs.
Rougvie
Ann E
AE
University of Minnesota, Department of Genetics, Cell Biology and Development, Minneapolis, 55455, USA. rougvie@umn.edu
D020413:3' Untranslated Regions / Q000235:genetics / Q000378:metabolism; D000818:Animals; D017173:Caenorhabditis elegans / Q000187:drug effects / Q000235:genetics / Q000254:growth & development; D029742:Caenorhabditis elegans Proteins / Q000819:agonists / Q000235:genetics / Q000378:metabolism*; D002782:Cholestenes / Q000494:pharmacology; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D049452:Green Fluorescent Proteins / Q000235:genetics / Q000378:metabolism; D008024:Ligands; D035683:MicroRNAs / Q000235:genetics*; D008954:Models, Biological; D009154:Mutation; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D018160:Receptors, Cytoplasmic and Nuclear / Q000819:agonists / Q000235:genetics / Q000378:metabolism*; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism
D020413:3' Untranslated Regions; D029742:Caenorhabditis elegans Proteins; D002782:Cholestenes; C410905:DAF-12 protein, C elegans; C492744:Din-1 protein, C elegans; D008024:Ligands; C539890:MIRN241 microRNA, C elegans; D035683:MicroRNAs; D012333:RNA, Messenger; D018160:Receptors, Cytoplasmic and Nuclear; D011993:Recombinant Fusion Proteins; D014157:Transcription Factors; C533800:dafachronic acid; C474488:let-7 microRNA, C elegans; D049452:Green Fluorescent Proteins; D003577:Cytochrome P-450 Enzyme System; C486228:DAF-9 protein, C elegans