Efficient syntheses of alpha-pyridones and 3(2H)-isoquinolones through ruthenium-catalyzed cycloisomerization of 3-en-5-ynyl and o-alkynylphenyl nitrones.
We report a new catalytic synthesis of alpha-pyridones and 3(2H)-isoquinolones from readily available 3-en-5-ynyl nitrones and o-alkynylphenyl nitrones; the reaction mechanism is proposed to involve iminyl ketene species through an oxygen transfer process.
Pati
Kamalkishore
K
Department of Chemistry, National Tsing-Hua University, Hsinchu, 30043, Taiwan, ROC.
Liu
Rai-Shung
RS
D002384:Catalysis; D007536:Isomerism; D009589:Nitrogen Oxides / Q000737:chemistry*; D010100:Oxygen / Q000737:chemistry; D011728:Pyridones / Q000138:chemical synthesis* / Q000737:chemistry; D015363:Quinolones / Q000138:chemical synthesis* / Q000737:chemistry; D012428:Ruthenium / Q000737:chemistry*
D009589:Nitrogen Oxides; D011728:Pyridones; D015363:Quinolones; C015388:nitrones; D012428:Ruthenium; D010100:Oxygen