Acute valproic acid overdose: enhance elimination with multiple-doses activated charcoal.
Multiple dose activated charcoal (MDAC) is used to enhance elimination of toxic substance in acute poisoning. However, its role in acute valproic acid (VA) overdose is controversial. The authors report a case of VA overdose that successfully recovered with MDAC treatment. The half-life of VA in the presented patient was decreased from 12 to 8 hours during MDAC administration. MDAC treatment in acute poisoning enhanced VA elimination four times than without treatment. MDAC should be considered for the treatment of acute VA intoxication.
Vannaprasaht
Suda
S
Department of Pharmacology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Tiamkao
Somsak
S
Sirivongs
Dhavee
D
Piyavhatkul
Nawanant
N
D000138:Acidosis; D000208:Acute Disease; D000328:Adult; D000931:Antidotes / Q000627:therapeutic use*; D002606:Charcoal / Q000627:therapeutic use*; D062787:Drug Overdose / Q000188:drug therapy*; D005260:Female; D015600:Glasgow Coma Scale; D006801:Humans; D012372:ROC Curve; D014635:Valproic Acid / Q000506:poisoning*
D000931:Antidotes; D002606:Charcoal; D014635:Valproic Acid