title: Antifungal activity of micafungin in serum.
abstract: We have evaluated the antifungal activity of micafungin in serum by using the disk diffusion method with serum-free and serum-added micafungin standard curves. Serum samples from micafungin-treated patients have been shown to exhibit adequate antifungal activity, which was in proportion to both the applied dose and the actual concentration of micafungin measured by high-performance liquid chromatography. The antifungal activity of micafungin in serum was also confirmed with the broth microdilution method.
authors.affiliation: Department of Hematology and Oncology, Osaka University School of Medicine, Suita, Osaka, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Ishikawa
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Maeda
authors.forename: Itaru
authors.initials: I
authors.lastname: Matsumura
authors.forename: Masato
authors.initials: M
authors.lastname: Yasumi
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Ujiie
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Masaie
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Nakazawa
authors.forename: Nobuo
authors.initials: N
authors.lastname: Mochizuki
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kishino
authors.forename: Yuzuru
authors.initials: Y
authors.lastname: Kanakura
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000493:pharmacokinetics / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects*; D002851:Chromatography, High Pressure Liquid; D054714:Echinocandins / Q000493:pharmacokinetics / Q000494:pharmacology*; D005260:Female; D006801:Humans; D055666:Lipopeptides / Q000493:pharmacokinetics / Q000494:pharmacology*; D008297:Male; D000077551:Micafungin; D008875:Middle Aged; D044967:Serum / Q000382:microbiology*; D055815:Young Adult
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D000077551:Micafungin
references.citation: Antimicrob Agents Chemother. 2007 Nov;51(11):4214-6
references.pmid: 17785512
references.citation: Antimicrob Agents Chemother. 2007 Jun;51(6):2253-6
references.pmid: 17420211
references.citation: Clin Infect Dis. 2002 Jan 1;34(1):7-14
references.pmid: 11731939
references.citation: Biol Pharm Bull. 2006 Aug;29(8):1706-11
references.pmid: 16880629
references.citation: Antimicrob Agents Chemother. 2000 Jan;44(1):57-62
references.pmid: 10602723
references.citation: Leuk Lymphoma. 2009 Jan;50(1):92-100
references.pmid: 19172498
references.citation: Infection. 1995 Sep-Oct;23(5):292-7
references.pmid: 8557388
references.citation: Microbiol Immunol. 2008 Aug;52(8):383-91
references.pmid: 18667037