Short- and long-term effects of UV radiation on the pigmentation of human skin.
The incidence of skin cancer, including cutaneous melanoma, has risen substantially in recent years, and epidemiological and laboratory studies show that UV radiation is a major causative factor of this increase. UV damage also underlies photoaging of the skin, and these deleterious effects of UV can be, in part, prevented in skin with higher levels of constitutive pigmentation. We review the clinical studies we have made in recent years regarding the rapid and the long-term responses of the pigmentary system in human skin to UV exposure.Journal of Investigative Dermatology Symposium Proceedings (2009) 14, 32-35; doi:10.1038/jidsymp.2009.10.
Coelho
Sergio G
SG
Pigment Cell Biology Section, Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Choi
Wonseon
W
Brenner
Michaela
M
Miyamura
Yoshinori
Y
Yamaguchi
Yuji
Y
Wolber
Rainer
R
Smuda
Christoph
C
Batzer
Jan
J
Kolbe
Ludger
L
Ito
Shosuke
S
Wakamatsu
Kazumasa
K
Zmudzka
Barbara Z
BZ
Beer
Janusz Z
JZ
Miller
Sharon A
SA
Hearing
Vincent J
VJ
D002452:Cell Count; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D007150:Immunohistochemistry; D008543:Melanins / Q000378:metabolism; D008544:Melanocytes / Q000378:metabolism / Q000473:pathology / Q000528:radiation effects; D012867:Skin / Q000378:metabolism / Q000473:pathology / Q000528:radiation effects; D012880:Skin Pigmentation / Q000528:radiation effects*; D013997:Time Factors; D014466:Ultraviolet Rays / Q000009:adverse effects*
D008543:Melanins
J Natl Cancer Inst. 2002 Jan 16;94(2):94-101
11792747
J Invest Dermatol. 2005 Jun;124(6):1326-32
15955111
N Engl J Med. 1999 Apr 29;340(17):1341-8
10219070
FASEB J. 2006 Jul;20(9):1486-8
16793869
J Investig Dermatol Symp Proc. 2001 Nov;6(1):99-104
11764295
J Invest Dermatol. 1987 Oct;89(4):384-8
3668281
J Investig Dermatol Symp Proc. 1998 Aug;3(1):47-51
9732058
Pigment Cell Melanoma Res. 2008 Aug;21(4):487-91
18627527
Br J Dermatol. 2008 Sep;159(4):921-30
18616777
Photochem Photobiol. 2008 May-Jun;84(3):539-49
18435612
J Invest Dermatol. 1998 May;110(5):806-10
9579550
J Invest Dermatol. 2009 Apr;129(4):1002-11
18946495
J Cell Biol. 2004 Apr 26;165(2):275-85
15117970
Photodermatol Photoimmunol Photomed. 2000 Dec;16(6):245-9
11132126
Eur J Dermatol. 1999 Mar;9(2):95-9
10066954
Dermatol Clin. 2003 Oct;21(4):725-32, x
14717413
Arch Dermatol Res. 2008 Apr;300 Suppl 1:S43-50
17985102
J Cell Biol. 1975 May;65(2):481-8
1127019
J Biol Chem. 2007 Sep 21;282(38):27557-61
17635904
N Engl J Med. 1993 Oct 14;329(16):1193-4
8377786
Pigment Cell Melanoma Res. 2009 Apr;22(2):238-41
19226313
Exp Dermatol. 2008 Nov;17(11):916-24
18363705
Pigment Cell Res. 2007 Feb;20(1):2-13
17250543
Photodermatol Photoimmunol Photomed. 2006 Jun;22(3):124-8
16719864
J Int Med Res. 1990;18 Suppl 3:8C-17C
2227089
FASEB J. 2003 Jun;17(9):1177-9
12692083
J Invest Dermatol. 1986 Nov;87(5):648-52
3772158