title: Recurrent acute cerebellar ataxia associated with anti-cardiolipin antibodies.
abstract: Various autoantibodies are detected in patients with acute cerebellar ataxia (ACA). Although an autoimmune process may contribute to the mechanism of ACA, its pathophysiology is not completely understood. We report a girl with recurrent ACA and anti-cardiolipin antibodies. Her cerebral blood flow imaging showed hypoperfusion in the cerebellum, which improved when the anti-cardiolipin antibodies disappeared. Our case suggests that vasculopathy or non-vascular neurotoxicity in the cerebellum caused by antiphospholipid antibodies leads to acute cerebellar ataxia.
authors.affiliation: Department of Pediatrics, Hiroshima University Graduate School of Biomedical Sciences, Minami-ku, Hiroshima 734-8551, Japan. ishikan@hiroshima-u.ac.jp
authors.forename: Nobutsune
authors.initials: N
authors.lastname: Ishikawa
authors.forename: Masao
authors.initials: M
authors.lastname: Kobayashi
mesh_terms: D017153:Antibodies, Anticardiolipin / Q000009:adverse effects / Q000097:blood / Q000276:immunology; D002524:Cerebellar Ataxia / Q000097:blood / Q000209:etiology / Q000276:immunology; D002531:Cerebellum / Q000473:pathology / Q000503:physiopathology; D002675:Child, Preschool; D005260:Female; D006801:Humans; D012008:Recurrence; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D017153:Antibodies, Anticardiolipin