title: Autologous peripheral blood stem cell transplantation for chronic acquired demyelinating neuropathy.
abstract: Six patients with chronic acquired demyelinating neuropathy (CADP) were treated with autologous peripheral blood stem cell transplantation (PBSCT). Two with polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes (POEMS) syndrome improved-improvement was sustained in one but relapsed and required repeat transplant in the other. Two of the three with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and one with an IgM paraprotein and antibodies to nerve improved--of the responders, one relapsed after 18 months and the other was in remission after 6 months. Four developed neutropenic septicemia and pneumonia. The role of PBSCT in CADP refractory to other treatment deserves further investigation but the serious adverse events and lack of sustained response in some patients emphasize the need for caution.
authors.affiliation: Department of Clinical Neuroscience, King's College London, London, UK.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Mahdi-Rogers
authors.forename: Majid
authors.initials: M
authors.lastname: Kazmi
authors.forename: Rosalie
authors.initials: R
authors.lastname: Ferner
authors.forename: Richard A C
authors.initials: RA
authors.lastname: Hughes
authors.forename: Susanne
authors.initials: S
authors.lastname: Renaud
authors.forename: Andreas J
authors.initials: AJ
authors.lastname: Steck
authors.forename: Peter
authors.initials: P
authors.lastname: Fuhr
authors.forename: Jörg
authors.initials: J
authors.lastname: Halter
authors.forename: Alois
authors.initials: A
authors.lastname: Gratwohl
authors.forename: Alan
authors.initials: A
authors.lastname: Tyndall
mesh_terms: D000328:Adult; D000368:Aged; D002908:Chronic Disease; D003711:Demyelinating Diseases / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000209:etiology; D016878:POEMS Syndrome / Q000628:therapy; D036102:Peripheral Blood Stem Cell Transplantation / Q000009:adverse effects; D011014:Pneumonia / Q000209:etiology; D020277:Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / Q000628:therapy; D012008:Recurrence; D012189:Retrospective Studies; D018805:Sepsis / Q000209:etiology; D014182:Transplantation, Autologous; D016896:Treatment Outcome