title: QSAR studies on 4-quinolone derivatives as high-affinity ligands at the benzodiazepine site of brain GABA(A) receptors.
abstract: Quantitative structure activity relationship approach using stepwise regression analysis was applied to a series of 4-quinolone derivatives as high-affinity ligands at the benzodiazepine site of brain GABA(A) receptors. For the purpose 25 compounds were used to develop models. Statistically significant equations were obtained with high squared correlation coefficient (r(2)=0.8761, 0.9295 and 0.8705) and low root mean square error (RMSE=0.4844, 0.3894 and 0.4952). The robustness of the model was confirmed with the help of leave one out cross validation method which exhibited high r(2)(cv) values (r(2)(cv)=0.7875, 0.8263 and 0.7927). A good correlation of various molecular shape parameters, like ovality, Szeged index, and energy of the molecule with the GABA(A) affinity was achieved.
authors.affiliation: School of Pharmaceutical Sciences, Shobhit University, Meerut, 250110, India. anand.pharma@gmail.com
authors.forename: Anand
authors.initials: A
authors.lastname: Gaurav
authors.forename: Mange R
authors.initials: MR
authors.lastname: Yadav
authors.forename: Rajani
authors.initials: R
authors.lastname: Giridhar
authors.forename: Vertika
authors.initials: V
authors.lastname: Gautam
authors.forename: Ranjit
authors.initials: R
authors.lastname: Singh
mesh_terms: D042462:4-Quinolones / Q000737:chemistry* / Q000378:metabolism*; D001569:Benzodiazepines / Q000378:metabolism*; D001665:Binding Sites; D055808:Drug Discovery; D008024:Ligands; D016014:Linear Models; D008958:Models, Molecular; D011485:Protein Binding; D021281:Quantitative Structure-Activity Relationship; D011963:Receptors, GABA-A / Q000737:chemistry* / Q000378:metabolism*; D015203:Reproducibility of Results
chemical_list: D042462:4-Quinolones; D008024:Ligands; D011963:Receptors, GABA-A; D001569:Benzodiazepines