title: Mesenteric venous thrombosis secondary to an unsuspected JAK2 V617F-positive myeloproliferative disorder.
abstract: BACKGROUND
  Mesenteric venous thrombosis (MVT) is a rare but potentially fatal cause of mesenteric ischaemia. It presents insidiously and often diagnosis is made at emergency surgery. In half of the cases MVT develops without a causative factor, while in cases in which a pro-thrombotic state is found to exist MVT may be the first clinically detected consequence of that state. The myeloproliferative disorders (MPD) are known to contribute to the development of pro-thrombotic states. Recently, the JAK2 V617F mutation has been associated with the MPDs.
  
  
  CONCLUSIONS
  We describe a case of MVT occurring secondary to an unsuspected MPD, in which the patient was subsequently found to carry this mutation. We highlight the necessity to screen for this mutation in cases of intra-abdominal thromboses so that appropriate systemic anticoagulation may be instituted, and the patient may be followed so as to detect the development of an overt MPD.
authors.affiliation: Department of Surgery, Mayo General Hospital, Mayo, Ireland. mikebourkecork@yahoo.co.uk
authors.forename: M G
authors.initials: MG
authors.lastname: Bourke
authors.forename: S T
authors.initials: ST
authors.lastname: Martin
authors.forename: M
authors.initials: M
authors.lastname: O'Dwyer
authors.forename: J
authors.initials: J
authors.lastname: Hanaghan
authors.forename: F
authors.initials: F
authors.lastname: Bennani
authors.forename: M K
authors.initials: MK
authors.lastname: Barry
mesh_terms: D002432:Cecum / Q000098:blood supply*; D005260:Female; D006801:Humans; D007082:Ileum / Q000098:blood supply*; D007238:Infarction / Q000209:etiology* / Q000601:surgery; D053614:Janus Kinase 2 / Q000235:genetics; D008642:Mesenteric Veins; D008875:Middle Aged; D009196:Myeloproliferative Disorders / Q000150:complications* / Q000235:genetics; D017354:Point Mutation; D020246:Venous Thrombosis / Q000209:etiology*
chemical_list: C507924:JAK2 protein, human; D053614:Janus Kinase 2
references.citation: Blood. 2007 Jan 1;109(1):339-42
references.pmid: 16946305
references.citation: Gastroenterology. 2006 Jun;130(7):2031-8
references.pmid: 16762626
references.citation: Blood. 2007 Aug 1;110(3):840-6
references.pmid: 17379742
references.citation: J Thromb Haemost. 2007 Apr;5(4):708-14
references.pmid: 17263783
references.citation: Curr Opin Genet Dev. 2007 Feb;17(1):8-14
references.pmid: 17208428
references.citation: N Engl J Med. 2005 Apr 28;352(17):1779-90
references.pmid: 15858187
references.citation: N Engl J Med. 2001 Dec 6;345(23):1683-8
references.pmid: 11759648
references.citation: Lancet. 2005 Mar 19-25;365(9464):1054-61
references.pmid: 15781101