Using new tools to define the genetic underpinnings of risky traits associated with coronary artery disease: the SardiNIA study.
Genomewide association studies are increasingly being applied to search for novel genes that might underlie cardiovascular diseases. In this article, we briefly review the principles that underlie modern genetic analyses and provide several illustrations from the SardiNIA study of genomewide association studies for cardiovascular risk factor traits.
Strait
James B
JB
Laboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
Uda
Manuela
M
Lakatta
Edward G
EG
Najjar
Samer S
SS
D001783:Blood Flow Velocity / Q000235:genetics; D001786:Blood Glucose / Q000235:genetics; D003324:Coronary Artery Disease / Q000235:genetics*; D006580:Genetic Carrier Screening / Q000379:methods*; D005819:Genetic Markers; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D007558:Italy; D015810:Linkage Disequilibrium / Q000235:genetics; D008074:Lipoproteins / Q000235:genetics; D009765:Obesity / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D019655:Quantitative Trait, Heritable; D014527:Uric Acid / Q000097:blood
D001786:Blood Glucose; D005819:Genetic Markers; D008074:Lipoproteins; D014527:Uric Acid
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