title: Synthesis of 1,2,4-triazine derivatives as potential anti-anxiety and anti-inflammatory agents.
abstract: A series of 1,2,4-triazine derivatives Va (1-24) and Vb (1-24) were synthesized and evaluated for their anti-anxiety and anti-inflammatory activities. The structures of the synthesized compounds were confirmed on the basis of their spectral data. Many of the triazine compounds were found to possess good activity. Especially, compounds bearing the sulfur atom showed better activity than those bearing the oxygen atom.
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard (Hamdard University) Hamdard Nagar, New Delhi-1 10062, India. poojamullick7@rediffmail.com
authors.forename: Pooja
authors.initials: P
authors.lastname: Mullick
authors.forename: Suroor A
authors.initials: SA
authors.lastname: Khan
authors.forename: Tauseef
authors.initials: T
authors.lastname: Begum
authors.forename: Surajpal
authors.initials: S
authors.lastname: Verma
authors.forename: Darpan
authors.initials: D
authors.lastname: Kaushik
authors.forename: Ozair
authors.initials: O
authors.lastname: Alam
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006835:Hydrazones / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology; D051381:Rats; D013329:Structure-Activity Relationship; D014227:Triazines / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D014151:Anti-Anxiety Agents; D000893:Anti-Inflammatory Agents; D006835:Hydrazones; D014227:Triazines; C093444:1,2,4-triazine