New cyclodextrin derivative 6-O-(2-hydroxybutyl)-beta-cyclodextrin: preparation and its application in molecular binding and recognition.
A new soluble cyclodextrin derivative 6-O-(2-hydroxybutyl)-beta-cyclodextrin (6-HB-beta-CD) was prepared. Its molecular binding and recognition ability were investigated with the comparison of beta-cyclodextrin (beta-CD), 2-O-(2-hydroxypropyl)-beta-cyclodextrin (2-HP-beta-CD), 6-O-(2-hydroxypropyl)-beta-cyclodextrin (6-HP-beta-CD), and 2-O-(2-hydroxybutyl)-beta-cyclodextrin (2-HB-beta-CD). The relationship between the complex stability constants and the possible structures of inclusion compounds was discussed with the interaction of hosts and guests, including the weak hydrophobic interactions, the size/shape matching, the steric hindrance, and the hydrophilic property.
Sun
Hong Yuan
HY
Shandong University, Jinan, PR China.
Bai
Yan
Y
Zhao
Ming Gang
MG
Hao
Ai You
AY
Xu
Gui Ying
GY
Shen
Jian
J
Li
Jian Ye
JY
Sun
Tao
T
Zhang
Hua Cheng
HC
D002942:Circular Dichroism; D004852:Epoxy Compounds / Q000737:chemistry; D015394:Molecular Structure; D047392:beta-Cyclodextrins / Q000138:chemical synthesis* / Q000737:chemistry*
D004852:Epoxy Compounds; D047392:beta-Cyclodextrins; C027488:1,2-epoxybutane; C031215:betadex