[Effect and significance of Shenmai injection on value of vascular endothelial active factors of heart valve replacement patients].
OBJECTIVE
To observe the effect of Shenmai injection on the value of vascular endothelial active factors nitric oxide (NO), endothelin-1 (ET-1) of patients undergoing heart valve rveplacement and cardiac pulmonary bypass (CPB).


METHODS
Thirty patients of cardiac valve replacement undergoing open heart surgery under cardiopulmonary bypass (CPB) were randomized single-blind method divided into Shenmai injection group (SM) and control group (C) with 15 cases each. Shenmai injection group (SM) were injected Shenmai injection 0.6 mL x kg(-1) added to physiological saline 250 mL after anaesthesia before CPB, the control control group were injected only physiological saline 250 mL at the same time. Blood samples were taken before induction of anesthesia and at 0.5, 2, 6, 24 hours after terminating CPB. To calculate P(A-a) DO2 and respiratory indexs (RI) by blood gas analysis, nitric oxide (NO) and endothelin-1 (ET-1) ET-1 were measured. At the same time, the time of CPB and artery blockage were recorded.


RESULTS
There was no statistical significance before operation between 2 groups to every blood index. After CPB, P(A-a) DO2 , RI and ET-1 was higher than pre-operation after CPB (P < 0.05). But P(A-a) DO2, RI and ET-I of Shenmai group were lower than control group evidently at every point after CPB (P < 0.05 or P < 0.01). The concentrations of NO were reduced obveiously after CPB (P < 0.05), but in shenmai group, the range of descent was lower than control group (P < 0.01 or P < 0.05).


CONCLUSIONS
The concentrations of NO and ET-1 is connected with the lung injury after CPB. Through rise the level of NO and reduce the level of ET-1, Shenmai injection can alleviate the lung injury in some degree after CPB and improve pulmonary oxygenation function.
Lin
Lina
L
The First Affiliated Hospital, Wenzhou Medical College, Wenzhou 325000, China. wzlinlina@tom.com
Wang
Liangrong
L
Chen
Feifei
F
Hu
Minglun
M
Miao
Jianxia
J
Wang
Jun
J
D000328:Adult; D001784:Blood Gas Analysis; D002315:Cardiopulmonary Bypass; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage* / Q000494:pharmacology*; D042783:Endothelial Cells / Q000187:drug effects* / Q000378:metabolism*; D019332:Endothelin-1 / Q000097:blood; D005260:Female; D006350:Heart Valve Prosthesis; D006801:Humans; D007267:Injections; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D019332:Endothelin-1; C009252:fructus schizandrae, radix ginseng, radix ophiopogonis drug combination; D009569:Nitric Oxide