title: T1r3 and alpha-gustducin in gut regulate secretion of glucagon-like peptide-1.
abstract: Glucagon-like peptide-1 (GLP-1) is an incretin hormone that underlies the augmented insulin release from the pancreas in response to glucose in the gut lumen more than to intravenous injected glucose (the "incretin effect"). GLP-1, found in enteroendocrine L cells of the gut, regulates appetite and gut motility and is released from L cells in response to glucose. GLP-1-expressing duodenal L cells also express T1r taste receptors, alpha-gustducin, and many other taste transduction elements. Knockout mice lacking alpha-gustducin or T1r3 have deficiencies in secretion of GLP-1 and in the regulation of plasma levels of insulin and glucose. Gut-expressed taste-signaling elements underlie multiple chemosensory functions of the gut including the incretin effect. Modulating hormone secretion from gut "taste cells" may provide novel treatments for obesity, diabetes, and malabsorption.
authors.affiliation: Department of Neuroscience, Mount Sinai School of Medicine, New York, New York 10029, USA.
authors.forename: Zaza
authors.initials: Z
authors.lastname: Kokrashvili
authors.forename: Bedrich
authors.initials: B
authors.lastname: Mosinger
authors.forename: Robert F
authors.initials: RF
authors.lastname: Margolskee
mesh_terms: D000818:Animals; D041981:Gastrointestinal Tract / Q000378:metabolism* / Q000502:physiology; D052216:Glucagon-Like Peptide 1 / Q000378:metabolism*; D051379:Mice; D018345:Mice, Knockout; D055099:Neuroendocrine Cells / Q000378:metabolism / Q000502:physiology; D043562:Receptors, G-Protein-Coupled / Q000502:physiology*; D015293:Transducin / Q000502:physiology*
chemical_list: D043562:Receptors, G-Protein-Coupled; C431926:taste receptors, type 1; C075192:gustducin; D052216:Glucagon-Like Peptide 1; D015293:Transducin