SOSS1/2: Sensors of single-stranded DNA at a break.
In this issue of Molecular Cell, Huang et al. (2009) describe two heterotrimeric single-stranded DNA binding complexes, SOSS1 and SOSS2, that function downstream of the MRN complex to promote DNA repair and the G2/M checkpoint.
Nam
Edward A
EA
Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Cortez
David
D
D002453:Cell Cycle / Q000235:genetics; D053903:DNA Breaks, Double-Stranded; D004260:DNA Repair / Q000235:genetics; D004277:DNA, Single-Stranded / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D042822:Genomic Instability; D006801:Humans; D055550:Protein Stability; D021122:Protein Subunits / Q000235:genetics / Q000378:metabolism / Q000502:physiology
D004277:DNA, Single-Stranded; D004268:DNA-Binding Proteins; D021122:Protein Subunits
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