title: Pt-catalyzed enantioselective diboration of terminal alkenes with B2(pin)2.
abstract: The Pt-catalyzed enantioselective addition of bis(pinacolato)diboron to simple monosubstituted alkenes is described. This reaction occurs in the presence of a readily available chiral phosphonite ligand and is effective with a variety of terminal alkene substrates. Importantly, the reaction can operate with catalyst loadings of only 1 mol % Pt. While oxidation of the intermediate 1,2-bis(boronate) ester provides the chiral 1,2-diol as the reaction product, the intermediate may also be subjected to homologation/oxidation to furnish a chiral 1,4-diol as the reaction product.
authors.affiliation: Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, USA.
authors.forename: Laura T
authors.initials: LT
authors.lastname: Kliman
authors.forename: Scott N
authors.initials: SN
authors.lastname: Mlynarski
authors.forename: James P
authors.initials: JP
authors.lastname: Morken
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D001895:Boron / Q000737:chemistry*; D002384:Catalysis; D010984:Platinum / Q000737:chemistry*; D013237:Stereoisomerism; D013379:Substrate Specificity
chemical_list: D000475:Alkenes; D010984:Platinum; D001895:Boron
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