Transfusion-related acute lung injury (TRALI): current concepts and misconceptions.
Transfusion-related acute lung injury (TRALI) is the most common cause of serious morbidity and mortality due to hemotherapy. Although the pathogenesis has been related to the infusion of donor antibodies into the recipient, antibody negative TRALI has been reported. Changes in transfusion practices, especially the use of male-only plasma, have decreased the number of antibody-mediated cases and deaths; however, TRALI still occurs. The neutrophil appears to be the effector cell in TRALI and the pathophysiology is centered on neutrophil-mediated endothelial cell cytotoxicity resulting in capillary leak and ALI. This review will detail the pathophysiology of TRALI including recent pre-clinical data, provide insight into newer areas of research, and critically assess current practices to decrease it prevalence and to make transfusion safer.
Silliman
Christopher C
CC
Research Department, Bonfils Blood Center, Denver CO 80230, USA. christopher.silliman@ucdenver.edu
Fung
Yoke Lin
YL
Ball
J Bradley
JB
Khan
Samina Y
SY
D000818:Animals; D001803:Blood Transfusion / Q000401:mortality*; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D055370:Lung Injury / Q000209:etiology* / Q000401:mortality; D008297:Male; D051379:Mice; D051381:Rats; D065227:Transfusion Reaction
Transfusion. 2009 Mar;49(3):440-52
18980623
Biochim Biophys Acta. 1998 Jan 23;1389(3):187-96
9512647
Transfusion. 2002 Nov;42(11):1523
12421228
Blood. 2006 Feb 1;107(3):1217-9
16210340
J Leukoc Biol. 1999 Jul;66(1):10-24
10410985
Transfusion. 2003 Apr;43(4):545-6
12662291
Am J Physiol Heart Circ Physiol. 2000 Sep;279(3):H1338-45
10993801
Transfus Apher Sci. 2003 Aug;29(1):25-7
12877889
Am J Clin Pathol. 2007 Jul;128(1):128-34
17580280
Intensive Care Med. 1988;14(6):654-7
3183192
Vox Sang. 2002 Aug;83 Suppl 1:299-303
12617157
J Leukoc Biol. 2003 Apr;73(4):511-24
12660226
J Gen Virol. 2004 Jul;85(Pt 7):1801-1813
15218164
Vox Sang. 2008 Jan;94(1):70-3
18171330
Blood. 2005 Mar 15;105(6):2266-73
15572582
Transfusion. 2002 Aug;42(8):1102
12385425
J Clin Invest. 1988 Mar;81(3):676-82
3278004
Clin Exp Immunol. 2003 Sep;133(3):476-84
12930377
Br J Haematol. 1999 May;105(2):322-9
10233400
Transfusion. 1996 Feb;36(2):133-9
8614963
Hum Immunol. 1988 Feb;21(2):115-24
3284856
Transfusion. 2007 Mar;47(3):545-50
17319838
J Burn Care Res. 2007 Jan-Feb;28(1):56-64
17211201
Semin Hematol. 1974 Jul;11(3):281-90
4134542
Crit Care Med. 2007 Jul;35(7):1645-8
17522583
Crit Care Med. 2004 May;32(5 Suppl):S202-8
15118518
Transfusion. 2003 Aug;43(8):1053-9
12869110
Crit Care Med. 2005 Apr;33(4):721-6
15818095
J Trauma. 2005 Sep;59(3):717-23
16361918
Am J Respir Crit Care Med. 2007 Nov 1;176(9):886-91
17626910
Blood. 2006 Oct 1;108(7):2455-62
16772606
J Immunol. 1993 Aug 1;151(3):1482-90
8335942
Science. 1989 Jul 14;245(4914):183-6
2749255
Anesthesiology. 2009 Feb;110(2):351-60
19164959
Vox Sang. 2007 Jul;93(1):78-82
17547569
Transfus Med. 2004 Jun;14(3):225-30
15180814
Chem Pharm Bull (Tokyo). 1987 Jan;35(1):436-9
3109754
J Exp Med. 1997 Oct 20;186(8):1401-6
9334381
Transfus Med Rev. 1996 Jul;10(3):222-32
8809971
Transfusion. 2009 Sep;49(9):1825-35
19453983
Shock. 2001 Aug;16(2):143-7
11508867
Transfusion. 2003 Dec;43(12):1683-6
14641864
Immunohematology. 2004;20(2):103-11
15373658
Intensive Care Med. 2007 Jun;33 Suppl 1:S17-21
17676435
Methods Mol Biol. 1999;120:119-44
10343315
Proc Am Thorac Soc. 2005;2(3):243-7
16222045
Shock. 2007 Dec;28(6):668-674
18092384
J Lab Clin Med. 1993 Mar;121(3):372-4
8445282
Am J Clin Pathol. 1999 Aug;112(2):216-21
10439802
Lancet. 1984 Feb 4;1(8371):244-6
6142994
Resuscitation. 2003 Jul;58(1):121
12867319
J Clin Invest. 2006 Jun;116(6):1615-23
16710475
Neurosci Lett. 2008 Nov 7;445(1):18-22
18782601
J Clin Invest. 1998 Apr 1;101(7):1458-67
9525989
Transfusion. 2001 Mar;41(3):317-22
11274583
Transfus Med. 2008 Dec;18(6):348-54
19140817
Transfusion. 2004 Dec;44(12):1683-8
15584980
J Crit Care. 1994 Mar;9(1):72-81
8199655
Microcirculation. 2001 Apr;8(2):71-88
11379793
Blood. 2007 Feb 15;109(4):1752-5
17038531
Br J Haematol. 1996 Jun;93(3):707-13
8652399
Hum Immunol. 1995 May;43(1):45-50
7558928
Vox Sang. 2005 Jul;89(1):1-10
15938734
J Infect Dis. 1998 Jun;177(6):1465-74
9607821
Vox Sang. 2009 Apr;96(3):266-9
19207164
Lab Invest. 1991 Aug;65(2):145-59
1908922
Transfusion. 2009 Mar;49(3):402-5
19243538
Vox Sang. 2008 Nov;95(4):313-7
19138261
JAMA. 2002 Apr 17;287(15):1968-71
11960539
Transfus Med. 2001 Dec;11(6):403-17
11851938
Transfusion. 1997 Jul;37(7):719-26
9225936
Blood Rev. 2006 May;20(3):139-59
16360246
J Immunol. 2005 Jun 1;174(11):7359-67
15905583
Immunol Res. 2006;36(1-3):255-64
17337786
Ann N Y Acad Sci. 1994 May 28;725:91-103
7518215
Lancet. 2002 Oct 5;360(9339):1073-4
12383991
Vox Sang. 2007 Jul;93(1):70-7
17547568
Transfusion. 2007 Apr;47(4):599-607
17381617
Blood. 2009 Feb 26;113(9):2079-87
19131548
FASEB J. 1994 May;8(8):504-12
8181668
Blood. 2003 Jan 15;101(2):454-62
12393667
N Engl J Med. 1995 Jan 5;332(1):27-37
7646623
Transfusion. 2003 May;43(5):633-40
12702186
Crit Care. 2007;11(3):R63
17553147
J Trauma. 2006 Jun;60(6 Suppl):S46-50
16763481
Crit Care Med. 2006 May;34(5 Suppl):S124-31
16617256
J Am Med Assoc. 1957 Oct 19;165(7):819-25
13462853
Shock. 2001 Apr;15(4):302-6
11303730
Transfusion. 2002 Apr;42(4):462-8
12076294
Hepatobiliary Pancreat Dis Int. 2002 Aug;1(3):330-4
14607702
Transfusion. 1992 Jul-Aug;32(6):589-92
1502715
Transfusion. 2008 Jun;48(6):1174-9
18422853
Transfus Med Rev. 1999 Jul;13(3):177-86
10425690
Chest. 2007 May;131(5):1308-14
17400669
J Biol Chem. 1996 Jul 26;271(30):17944-8
8663438
Langenbecks Arch Surg. 2006 Sep;391(5):489-94
16909292
J Immunol. 2001 Apr 1;166(7):4644-9
11254723
J Lab Clin Med. 1994 Nov;124(5):684-94
7964126
J Trauma. 2007 Jan;62(1):112-9
17215741
Artif Organs. 1995 Aug;19(8):801-7
8572999
Transfus Med. 2004 Oct;14(5):375-83
15500457
Transplantation. 2008 Aug 15;86(3):384-90
18698240
J Clin Invest. 1990 Apr;85(4):1135-43
2318970
Transfusion. 2003 Aug;43(8):1038-46
12869108
Ann Intern Med. 1983 May;98(5 Pt 1):593-7
6846973
Am Rev Respir Dis. 1993 Jan;147(1):168-76
8420413
Vox Sang. 1990;59(1):62
2396376
Transfusion. 2008 Dec;48(12):2549-58
18717778
Chest. 2004 Jul;126(1):249-58
15249468
Transfusion. 2001 Oct;41(10):1244-8
11606823
Am J Physiol Heart Circ Physiol. 2007 Sep;293(3):H1847-52
17616742
Am J Physiol Cell Physiol. 2002 Dec;283(6):C1592-603
12388071
Transfus Med. 2007 Apr;17(2):129-34
17430469
Blood. 1994 Oct 1;84(7):2068-101
7522621
Blood. 1990 Oct 1;76(7):1438-44
2207319
J Am Coll Surg. 1994 Nov;179(5):529-37
7952454
Transfusion. 2005 Aug;45(2 Suppl):109S-116S
16086797
Vox Sang. 2007 Apr;92(3):247-9
17348874
Anesthesiology. 1998 Oct;89(4):1020-3
9778020
Transfusion. 1990 Jan;30(1):42-5
2296790
JAMA. 2002 Jul 17;288(3):315-6; author reply 316
12117393
Arterioscler Thromb Vasc Biol. 2006 Mar;26(3):462-7
16357316
Transfus Med. 2004 Apr;14(2):157-64
15113380
Vox Sang. 1978;35(5):294-303
99875
Nat Med. 2009 Apr;15(4):384-91
19305412
Transfusion. 1985 Nov-Dec;25(6):573-7
4071603
Br J Anaesth. 2003 May;90(5):573-6
12697582
J Surg Res. 1999 Sep;86(1):42-9
10452867
Transfusion. 2003 Feb;43(2):185-91
12559014
Cytokine. 1995 Aug;7(6):479-82
8580362
Transfusion. 2003 Feb;43(2):177-84
12559013
Transfus Med Rev. 2004 Jul;18(3):184-8
15248168
Transfusion. 2004 Dec;44(12):1774-89
15584994
J Pediatr Hematol Oncol. 2006 Jun;28(6):391-4
16794510
Lancet. 2001 Jun 23;357(9273):2023-4
11438137
J Appl Physiol (1985). 1988 Oct;65(4):1861-71
3182546
Intern Med J. 2003 Jul;33(7):286-90
12823673
J Appl Physiol (1985). 1990 Nov;69(5):1767-78
2272970
Transfusion. 2007 Jan;47(1):154-61
17207244
Haematologica. 1998 Jun;83(6):573-5
9676035
J Leukoc Biol. 2001 Jul;70(1):80-6
11435489
Am J Surg. 1982 Jul;144(1):124-30
7091520
Lancet. 1998 Nov 14;352(9140):1601-2
9843115