title: Cassiaindoline, a new analgesic and anti-inflammatory alkaloid from Cassia alata.
abstract: Cassiaindoline is a new dimeric indole alkaloid isolated from Cassia alata L. leaves whose structure was elucidated through spectroscopic analyses. It exhibited analgesic activity at a dosage of 125.0 mg/kg mouse and decreased the number of writhings induced by acetic acid by 49.4%. It also showed a 57.1% anti-inflammatory activity at a dosage of 75 mg/kg mouse.
authors.affiliation: Institute of Chemistry, University of the Philippines, Diliman, Quezon City 1101, Philippines. irene.villasenor@up.edu.ph
authors.forename: Irene M
authors.initials: IM
authors.lastname: Villaseñor
authors.forename: Arlyn C
authors.initials: AC
authors.lastname: Sanchez
mesh_terms: D000470:Alkaloids / Q000302:isolation & purification* / Q000627:therapeutic use; D000700:Analgesics / Q000302:isolation & purification* / Q000627:therapeutic use; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification* / Q000627:therapeutic use; D002351:Carrageenan / Q000633:toxicity; D002366:Cassia / Q000737:chemistry*; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D018514:Plant Structures
chemical_list: D000470:Alkaloids; D000700:Analgesics; D000893:Anti-Inflammatory Agents; D002351:Carrageenan