Endolymphatic hydrops revealed by intravenous gadolinium injection in patients with Ménière's disease.
CONCLUSIONS
Visualization of endolymphatic hydrops became possible after intravenous gadolinium (Gd) injection in patients with Ménière's disease.


OBJECTIVE
To visualize endolymphatic hydrops after intravenous Gd injection.


METHODS
Gd (gadoteridol; 0.2 mmol/kg) was injected intravenously in three patients with unilateral Ménière's disease. We performed three-dimensional fluid attenuated inversion recovery (3D-FLAIR) and three-dimensional real inversion recovery (3D-real IR) magnetic resonance imaging (MRI) 4 h after the injection using a 3-Tesla MRI unit. We used a 32-channel array coil to obtain a high signal-to-noise ratio.


RESULTS
Endolymphatic hydrops was observed in the ears of patients with Ménière's disease. However, Gd concentration in the perilymph was lower compared with that obtained after intratympanic Gd injection.
Nakashima
Tsutomu
T
Department of Otorhinolaryngology, Nagoya University, Nagoya, Japan. tsutomun@med.nagoya-u.ac.jp
Naganawa
Shinji
S
Teranishi
Masaaki
M
Tagaya
Mitsuhiko
M
Nakata
Seiichi
S
Sone
Michihiko
M
Otake
Hironao
H
Kato
Ken
K
Iwata
Tomoyuki
T
Nishio
Naoki
N
D000328:Adult; D000368:Aged; D003051:Cochlea / Q000473:pathology; D003287:Contrast Media; D018159:Endolymphatic Hydrops / Q000175:diagnosis*; D005260:Female; D005682:Gadolinium; D006319:Hearing Loss, Sensorineural / Q000175:diagnosis; D006571:Heterocyclic Compounds; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D007275:Injections, Intravenous; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008575:Meniere Disease / Q000175:diagnosis*; D008875:Middle Aged; D009464:Neuroma, Acoustic / Q000473:pathology; D009942:Organometallic Compounds; D014722:Vestibule, Labyrinth / Q000473:pathology
D003287:Contrast Media; D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; C062402:gadoteridol; D005682:Gadolinium