title: High-yielding synthesis of Nefopam analogues (functionalized benzoxazocines) by sequential one-pot cascade operations.
abstract: An efficient amine-/ruthenium-catalyzed three-step process for the synthesis of Nefopam analogues was achieved through combinations of cascade enamine amination/iso-aromatization/allylation and diene or enyne metathesis as key steps starting from functionalized Hagemann's esters. In this communication, we discovered the application of ruthenium-catalysis on olefins containing free amines without in situ formation of salts.
authors.affiliation: School of Chemistry, University of Hyderabad, Hyderabad-500 046, India. ramsc@uohyd.ernet.in
authors.forename: Dhevalapally B
authors.initials: DB
authors.lastname: Ramachary
authors.forename: Vidadala V
authors.initials: VV
authors.lastname: Narayana
authors.forename: M Shiva
authors.initials: MS
authors.lastname: Prasad
authors.forename: Kinthada
authors.initials: K
authors.lastname: Ramakumar
mesh_terms: D000475:Alkenes / Q000737:chemistry; D000588:Amines / Q000737:chemistry; D001583:Benzoxazoles / Q000737:chemistry*; D002384:Catalysis; D009340:Nefopam / Q000031:analogs & derivatives* / Q000138:chemical synthesis*; D055601:Organic Chemistry Phenomena; D012428:Ruthenium
chemical_list: D000475:Alkenes; D000588:Amines; D001583:Benzoxazoles; D009340:Nefopam; D012428:Ruthenium