title: Clinical evaluation of topical tacalcitol efficacy in extending the remission period between nb-UVB phototherapy cycles in psoriatic patients.
abstract: Psoriasis is a very common dermatological disease affecting a large part of the world population. In its most common form, psoriasis vulgaris, many topical drugs are available to treat the localized forms, and the recurrence of the dermatosis. Among topicals, tacalcitol has been proven to be effective and devoid of side effects which are typical of Vitamin-D3 analogues or derivates. The aim of this retrospective study was to evaluate the efficacy of topical tacalcitol vs. calcipotriol and emollient treatment of the first recurring lesion in order to induce a longer remission period before the retreatment with nb-UVB phototherapy in a population of 90 psoriatic patients. In this trial, the time between the first relapsing plaque appearance and retreatment with nb-UVB resulted in 25, 16 and 11 days for tacalcitol, calcipotriol and emollient respectively, with a statistically significant difference for tacalcitol (p < 0.0001). These results proved that tacalcitol treatment is effective in increasing the time interval in consecutive phototherapy cycles and in reducing the total amount of UV exposure.
authors.affiliation: Departmentof Dermatological Sciences, University of Firenze, Firenze, Italy. francesca.prignano@unifi.it
authors.forename: Francesca
authors.initials: F
authors.lastname: Prignano
authors.forename: Gionata
authors.initials: G
authors.lastname: Buggiani
authors.forename: Torello
authors.initials: T
authors.lastname: Lotti
mesh_terms: D000287:Administration, Topical; D000328:Adult; D002117:Calcitriol / Q000031:analogs & derivatives / Q000627:therapeutic use; D015331:Cohort Studies; D003879:Dermatologic Agents / Q000008:administration & dosage*; D004100:Dihydroxycholecalciferols / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000188:drug therapy* / Q000532:radiotherapy*; D012189:Retrospective Studies; D016896:Treatment Outcome; D014467:Ultraviolet Therapy / Q000379:methods*
chemical_list: D003879:Dermatologic Agents; D004100:Dihydroxycholecalciferols; C055085:calcipotriene; C023850:1 alpha,24-dihydroxyvitamin D3; D002117:Calcitriol