From IL-10 to IL-12: how pathogens and their products stimulate APCs to induce T(H)1 development.
The authors recount their discovery of how pathogen-induced interleukin 12 production leads to T(H)1 T cell polarization. Simultaneously they discovered the suppressive cytokine interleukin 10 inhibits antigen-presenting cells, thus regulating development of T(H)1 cells.
O'Garra
Anne
A
Division of Immunoregulation, The Medical Research Council National Institute for Medical Research, London, UK. aogarra@nimr.mrc.ac.uk
Murphy
Kenneth M
KM
D000818:Animals; D000938:Antigen-Presenting Cells / Q000502:physiology*; D002454:Cell Differentiation; D016764:Cell Polarity; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis; D016753:Interleukin-10 / Q000502:physiology*; D018664:Interleukin-12 / Q000502:physiology*; D008264:Macrophages / Q000502:physiology; D018417:Th1 Cells / Q000502:physiology*; D018418:Th2 Cells / Q000502:physiology
D016753:Interleukin-10; D018664:Interleukin-12; D007371:Interferon-gamma
Int Immunol. 1990;2(9):821-32
1703785
J Exp Med. 1989 Dec 1;170(6):2081-95
2531194
J Exp Med. 1994 Jul 1;180(1):223-31
7516409
Proc Natl Acad Sci U S A. 1992 Jul 1;89(13):6065-9
1385868
J Exp Med. 1995 May 1;181(5):1755-62
7722452
Science. 1990 Dec 21;250(4988):1720-3
2125367
Science. 1993 Apr 23;260(5107):547-9
8097338
J Exp Med. 1996 Mar 1;183(3):901-13
8642294
Proc Natl Acad Sci U S A. 1991 Feb 15;88(4):1172-6
1847510
J Immunol. 1991 May 1;146(9):3074-81
1673147
Cell. 1996 Sep 20;86(6):973-83
8808632
Annu Rev Immunol. 2000;18:451-94
10837066
Nature. 1997 Jul 24;388(6640):394-7
9237759
Int Immunol. 1993 Sep;5(9):1119-28
7902129
J Immunol. 1991 May 15;146(10):3444-51
1827484
Science. 1990 Jun 8;248(4960):1230-4
2161559
Annu Rev Immunol. 1993;11:165-90
8386517
Proc Natl Acad Sci U S A. 1998 Jan 20;95(2):588-93
9435236
Immunity. 1995 Jun;2(6):665-75
7796298
J Immunol. 1993 May 1;150(9):3755-65
8097224
J Immunol. 1990 Dec 1;145(11):3796-806
2147202
J Exp Med. 1991 Apr 1;173(4):869-79
1672545
J Immunol. 1986 Apr 1;136(7):2348-57
2419430
Immunol Rev. 2008 Jun;223:114-31
18613832
J Exp Med. 1990 Sep 1;172(3):921-9
2117636
Mol Cell Biol. 1995 Oct;15(10):5258-67
7565674
Cold Spring Harb Symp Quant Biol. 1989;54 Pt 1:1-13
2700931
Nat Rev Immunol. 2002 Jan;2(1):55-60
11905838
Annu Rev Immunol. 2001;19:683-765
11244051
J Immunol. 1991 Dec 1;147(11):3815-22
1940369
J Immunol. 1995 May 15;154(10):5071-9
7730613
Immunol Today. 1988 Feb;9(2):45-54
3151436
Nat Rev Immunol. 2005 Apr;5(4):271-83
15775993
Eur J Immunol. 1992 Mar;22(3):711-7
1547817
Annu Rev Immunol. 1989;7:145-73
2523712
Science. 1998 Dec 11;282(5396):2085-8
9851930
Immunity. 2002 Jun;16(6):755-8
12121657
Int Immunol. 1993 Apr;5(4):371-82
8494824