title: pH clock-operated mechanized nanoparticles.
abstract: Mechanized nanoparticles (MNPs) consisting of supramolecular machines attached to the surface of mesoporous silica nanoparticles are designed to release encapsulated guest molecules controllably under pH activation. The molecular machines are comprised of cucurbit[6]uril (CB[6]) rings that encircle tethered trisammonium stalks and can be tuned to respond under specific pH conditions through chemical modification of the stalks. Luminescence spectroscopy demonstrates that the MNPs are able to contain guest molecules within nanopores at neutral pH levels and then release them once the pH is lowered or raised.
authors.affiliation: Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, USA.
authors.forename: Sarah
authors.initials: S
authors.lastname: Angelos
authors.forename: Niveen M
authors.initials: NM
authors.lastname: Khashab
authors.forename: Ying-Wei
authors.initials: YW
authors.lastname: Yang
authors.forename: Ali
authors.initials: A
authors.lastname: Trabolsi
authors.forename: Hussam A
authors.initials: HA
authors.lastname: Khatib
authors.forename: J Fraser
authors.initials: JF
authors.lastname: Stoddart
authors.forename: Jeffrey I
authors.initials: JI
authors.lastname: Zink
mesh_terms: D003692:Delayed-Action Preparations / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D053758:Nanoparticles / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D003692:Delayed-Action Preparations; D012822:Silicon Dioxide