Boosting the suppressive effects of Ascaris suum components in IFN-gamma-deficient mice.
High molecular weight components from Ascaris suum extract suppress ovalbumin-specific immunity in mice. In IFN-gamma-deficient mice, ovalbumin-specific delayed-type hypersensitivity reactions are more strongly downregulated by these suppressive components. Here, the cellularity of the delayed-type hypersensitivity reaction in IFN-gamma-deficient mice and the increased downregulation induced by Ascaris suum components were analyzed. IL-12p40-dependent neutrophilic influx was predominant. Suboptimal doses of the suppressive fraction from this nematode completely inhibited the hypersensitivity reaction, thus indicating intensification of the immunosuppression under conditions of intense recruitment of IFN-gamma-independent neutrophils.
Souza
Valdênia Maria Oliveira
VM
Laboratory of Immunopathology Keizo Asami, Department of Pharmaceutical Sciences, Federal University of Pernambuco, Recife, PE, Brazil. valdenia.souza@ufpe.br
Macedo
Mahasti Sahihi
MS
D000818:Animals; D017165:Ascaris suum / Q000276:immunology*; D006968:Hypersensitivity, Delayed / Q000235:genetics / Q000276:immunology*; D007073:Immunoglobulin E / Q000096:biosynthesis; D007074:Immunoglobulin G / Q000096:biosynthesis; D007371:Interferon-gamma / Q000172:deficiency* / Q000235:genetics / Q000276:immunology; D007378:Interleukins / Q000096:biosynthesis; D051379:Mice; D010047:Ovalbumin / Q000008:administration & dosage / Q000276:immunology
D007074:Immunoglobulin G; D007378:Interleukins; D007073:Immunoglobulin E; D007371:Interferon-gamma; D010047:Ovalbumin