The sickness unto Deaf.
While promiscuous expression of tissue-specific antigens (TSAs) in the thymus is essential for self-tolerance, immunologically relevant TSA expression may also occur in the secondary lymphoid organs. A new study links the transcriptional regulator Deaf1 with altered TSA expression in the secondary lymphoid organs and autoimmune diabetes.
Gardner
James M
JM
Anderson
Mark S
MS
D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D004268:DNA-Binding Proteins; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology*; D008198:Lymph Nodes / Q000276:immunology*; D051379:Mice; D016688:Mice, Inbred NOD; D009687:Nuclear Proteins / Q000502:physiology*; D010179:Pancreas / Q000276:immunology*; D017634:Self Tolerance; D014157:Transcription Factors / Q000502:physiology; D000096927:AIRE Protein
D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; D014157:Transcription Factors; D000096927:AIRE Protein; C116013:DEAF1 protein, human
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