Antidiarrhoeal activity of carbazole alkaloids from Murraya koenigii Spreng (Rutaceae) seeds.
The bioassay guided fractionation of the n-hexane extract of the seeds of Murraya koenigii Spreng (Rutaceae) resulted in the isolation of three bioactive carbazole alkaloids, kurryam (I), koenimbine (II) and koenine (III). The structures of the compounds were confirmed from their (1)H-, (13)C-, and 2D-NMR spectral data. Of the three compounds (I) and (II) exhibited significant inhibitory activity against castor oil-induced diarrhoea and PGE(2)-induced enteropooling in rats. The compounds also produced a significant reduction in gastrointestinal motility in the charcoal meal test in Wistar rats.
Mandal
Suvra
S
Department of Chemistry, National Research Institute of Ayurveda for Drug Development, Bidhannagar, Kolkata - 700091, India.
Nayak
Anupam
A
Kar
Manoj
M
Banerjee
Samir K
SK
Das
Ashes
A
Upadhyay
S N
SN
Singh
R K
RK
Banerji
Avijit
A
Banerji
Julie
J
D000818:Animals; D000930:Antidiarrheals / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D002368:Castor Oil; D002400:Cathartics; D003967:Diarrhea / Q000139:chemically induced / Q000188:drug therapy*; D015232:Dinoprostone; D004157:Diphenoxylate; D004353:Drug Evaluation, Preclinical; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects; D026121:Indole Alkaloids / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D015394:Molecular Structure; D010120:Oxytocics; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D027821:Rutaceae / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry
D000930:Antidiarrheals; D002400:Cathartics; D026121:Indole Alkaloids; D010120:Oxytocics; D010936:Plant Extracts; D004157:Diphenoxylate; D002368:Castor Oil; D015232:Dinoprostone