title: In vivo anti-inflammatory and wound healing activities of Centaurea iberica Trev. ex Spreng.
abstract: OBJECTIVE
  Several Centaurea species (Asteraceae) are used in Turkish folk medicine to alleviate pain and inflammatory symptoms in rheumatoid arthritis, high fever, head ache and for wound healing. Particularly, the aerial part of Centaurea iberica Trev. ex Spreng. has been practiced on wounds for healing. In order to evaluate the anti-inflammatory and wound healing activities of the plant, extracts were prepared with variety of solvents: hexane, chloroform, ethyl acetate and aqueous methanol (85%) from the aerial parts of Centaurea iberica.
  
  
  METHODS
  The incision by using tensiometer and excision models were used in order to assess the effect of the plant extracts on wound healing in mice and rats. Results were also evaluated histopathologically. In vivo inhibitory effect of the extracts on acetic acid-induced increase in capillary permeability was studied for the assessment of anti-inflammatory activity.
  
  
  RESULTS
  The wound healing effect was comparatively evaluated with a reference ointment Madecassol. Noteworthy wound healing activity was observed for the ointment formulation prepared with 1% methanol extract. The results of histopathological evaluation supported the outcome of both incision and excision wound models. Moreover, the methanol extract exerted remarkable wound healing activity and also demonstrated a significant and dose-dependent anti-inflammatory activity.
  
  
  CONCLUSIONS
  The experimental study revealed that Centaurea iberica displays remarkable wound healing and anti-inflammatory activity.
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Etiler 06330, Ankara, Turkey.
authors.forename: Ufuk
authors.initials: U
authors.lastname: Koca
authors.forename: Ipek Peşin
authors.initials: IP
authors.lastname: Süntar
authors.forename: Hikmet
authors.initials: H
authors.lastname: Keles
authors.forename: Erdem
authors.initials: E
authors.lastname: Yesilada
authors.forename: Esra Küpeli
authors.initials: EK
authors.lastname: Akkol
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D031179:Centaurea / Q000737:chemistry*; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D000893:Anti-Inflammatory Agents; D010936:Plant Extracts