title: Fatigue with systolic heart failure.
abstract: OBJECTIVE
  Fatigue is one of the most prevalent symptoms in persons with systolic heart failure (HF). There remains insufficient information about the physiological and psychosocial underpinnings of fatigue in HF. The specific aims of this study were to (1) determine the psychometric properties of 2 fatigue questionnaires in patients with HF, (2) compare fatigue in patients with HF to published scores of healthy adults and patients with cancer undergoing treatment, and (3) identify the physiological (eg, hemoglobin, B-type natriuretic peptide, body mass index, and ejection fraction) and psychosocial (eg, depressed mood) correlates of fatigue in HF.
  
  
  METHODS
  A convenience sample of 87 HF outpatients was recruited from 2 urban medical centers. Patients completed the Fatigue Symptom Inventory, Profile of Mood States, and Short Form-36 Health Survey.
  
  
  CONCLUSIONS
  Patients with HF and patients with cancer reported similar levels of fatigue, and both patient groups reported significantly more fatigue than did healthy adults. Physical functioning and hemoglobin categories explained 30% of the variance in Fatigue Symptom Inventory-Interference Scale scores, whereas depressed mood and physical functioning explained 47% of the variance in Profile of Mood States Fatigue subscale scores. Patients with HF experienced substantial fatigue that is comparable with cancer-related fatigue. Low physical functioning, depressed mood, and low hemoglobin level were associated with HF-related fatigue.
authors.affiliation: Department of Biobehavioral Health Science, University of Illinois at Chicago, Chicago, IL 60612-7350, USA.
authors.forename: Anne M
authors.initials: AM
authors.lastname: Fink
authors.forename: Shawna L
authors.initials: SL
authors.lastname: Sullivan
authors.forename: Julie J
authors.initials: JJ
authors.lastname: Zerwic
authors.forename: Mariann R
authors.initials: MR
authors.lastname: Piano
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D000740:Anemia / Q000097:blood / Q000150:complications; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D003866:Depressive Disorder / Q000150:complications; D005221:Fatigue / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D054143:Heart Failure, Systolic / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood; D009369:Neoplasms / Q000150:complications; D015995:Prevalence; D011446:Prospective Studies; D011594:Psychometrics; D012044:Regression Analysis; D012307:Risk Factors; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires / Q000592:standards*
chemical_list: D020097:Natriuretic Peptide, Brain
references.citation: Oncologist. 2007 Feb;12(2):221-30
references.pmid: 17296818
references.citation: Nat Clin Pract Cardiovasc Med. 2005 Apr;2(4):194-201
references.pmid: 16265483
references.citation: J Adv Nurs. 1993 Feb;18(2):260-8
references.pmid: 8436716
references.citation: Eur J Heart Fail. 2004 Mar 15;6(3):351-4
references.pmid: 14987587
references.citation: Ann N Y Acad Sci. 2006 Nov;1083:329-44
references.pmid: 17148748
references.citation: Heart Lung. 2008 Mar-Apr;37(2):122-31
references.pmid: 18371505
references.citation: Arthritis Care Res. 1990 Sep;3(3):154-7
references.pmid: 2285754
references.citation: Neuroimmunomodulation. 1995 Nov-Dec;2(6):319-28
references.pmid: 8840334
references.citation: J Pain Symptom Manage. 1997 Feb;13(2):63-74
references.pmid: 9095563
references.citation: Cancer. 2005 Jan 15;103(2):377-82
references.pmid: 15558809
references.citation: Qual Life Res. 1998 May;7(4):301-10
references.pmid: 9610214
references.citation: Eur J Heart Fail. 2006 Nov;8(7):744-9
references.pmid: 16690352
references.citation: Clin J Pain. 2005 May-Jun;21(3):200-6
references.pmid: 15818071
references.citation: J Clin Psychol. 1999 Jan;55(1):79-86
references.pmid: 10100834
references.citation: Med Care. 1994 Jan;32(1):40-66
references.pmid: 8277801
references.citation: Cancer Nurs. 1994 Oct;17(5):367-78
references.pmid: 7954384
references.citation: J Psychosom Res. 1991;35(4-5):399-407
references.pmid: 1920171
references.citation: J Cardiovasc Nurs. 2004 Nov-Dec;19(6 Suppl):S57-66
references.pmid: 15529075
references.citation: J Psychosom Res. 2006 Jun;60(6):559-66
references.pmid: 16731230
references.citation: Sleep Breath. 2008 Nov;12(4):397-9
references.pmid: 18516635
references.citation: Heart Lung. 1995 Nov-Dec;24(6):512-8
references.pmid: 8582827
references.citation: J Am Geriatr Soc. 2008 Oct;56(10):1915-9
references.pmid: 18771452
references.citation: Qual Life Res. 2000;9(7):847-54
references.pmid: 11297027
references.citation: J Am Acad Nurse Pract. 2008 Jun;20(6):326-32
references.pmid: 18588660
references.citation: Psychosom Med. 2003 Mar-Apr;65(2):181-93
references.pmid: 12651985
references.citation: J Am Coll Cardiol. 2002 Jun 5;39(11):1780-6
references.pmid: 12039491
references.citation: J Clin Epidemiol. 2002 Mar;55(3):239-44
references.pmid: 11864794
references.citation: Disabil Rehabil. 1996 May;18(5):249-54
references.pmid: 8743303
references.citation: J Pain Symptom Manage. 2004 Oct;28(4):373-80
references.pmid: 15471655
references.citation: Curr Opin Support Palliat Care. 2008 Sep;2(3):180-6
references.pmid: 18685418
references.citation: J Am Coll Cardiol. 2006 Oct 17;48(8):1527-37
references.pmid: 17045884
references.citation: J Card Fail. 2008 Aug;14(6):465-6
references.pmid: 18672193
references.citation: J Pain Symptom Manage. 2006 Sep;32(3):208-16
references.pmid: 16939845
references.citation: Psychosom Med. 2003 Jan-Feb;65(1):119-28
references.pmid: 12554823
references.citation: Eur J Heart Fail. 2007 Sep;9(9):922-7
references.pmid: 17631047
references.citation: Cardiovasc Drugs Ther. 2004 May;18(3):219-24
references.pmid: 15229390
references.citation: Nurs Res. 2000 Jul-Aug;49(4):181-90
references.pmid: 10929689
references.citation: Prog Cardiovasc Nurs. 2008 Winter;23(1):12-7
references.pmid: 18326992
references.citation: J Rheumatol. 1995 Apr;22(4):639-43
references.pmid: 7791155
references.citation: Heart Fail Clin. 2008 Jan;4(1):71-86
references.pmid: 18313626
references.citation: Circulation. 2005 Sep 20;112(12):e154-235
references.pmid: 16160202
references.citation: J Card Fail. 2005 May;11(4):288-92
references.pmid: 15880338
references.citation: Obesity (Silver Spring). 2008 Jul;16(7):1545-51
references.pmid: 18451777