title: Serotonin transporter promoter variant: Analysis in Indian IBS patients and control population.
abstract: BACKGROUND
  Studies of serotonin reuptake transporter (SERT-P) polymorphism and irritable bowel syndrome (IBS) have shown diverse results among different populations, which might be due to racial and ethnic difference.
  
  
  OBJECTIVE
  This study was to investigate the potential association between the SERT-P polymorphism and clinical subtypes of IBS patients in the Indian population.
  
  
  METHODS
  This prospective case-control study included 151 IBS patients. Ninety-two patients were diarrhea-predominant IBS, 44 were constipation-predominant IBS (C-IBS), 15 were alternating diarrhea and constipation IBS, and 100 were healthy controls. SERT gene polymorphism was studied by polymerase chain reaction.
  
  
  RESULTS
  A genotypic association was observed between SS genotype of SERT-P polymorphism and C-IBS (P<0.05). When the L/S and L/L genotypes were combined into one group, the frequency of the S/S genotype was significantly higher than that of the non-S/S genotype between C-IBS and the control group (P<0.05). There was no significant difference in the SERT-P genotype and allele frequency between c-ibs, alternating diarrhea and constipation IBS, all types of IBS cases, and controls.
  
  
  CONCLUSIONS
  A significant association was observed between the SS genotype of SERT-P polymorphism and C-IBS in the Indian population.
authors.affiliation: Department of Super Specialty of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: Arbab
authors.initials: A
authors.lastname: Sikander
authors.forename: Satya Vati
authors.initials: SV
authors.lastname: Rana
authors.forename: Saroj Kant
authors.initials: SK
authors.lastname: Sinha
authors.forename: Kaushal Kishor
authors.initials: KK
authors.lastname: Prasad
authors.forename: Sunil K
authors.initials: SK
authors.lastname: Arora
authors.forename: Sanjeev Kumar
authors.initials: SK
authors.lastname: Sharma
authors.forename: Kartar
authors.initials: K
authors.lastname: Singh
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003248:Constipation / Q000209:etiology; D003967:Diarrhea / Q000209:etiology; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007194:India; D043183:Irritable Bowel Syndrome / Q000208:ethnology / Q000235:genetics* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011446:Prospective Studies; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*
chemical_list: C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins