title: Urinary levoglucosan as a biomarker of wood smoke: results of human exposure studies.
abstract: Urinary levoglucosan was investigated as a potential biomarker of wood smoke exposure in two different controlled experimental settings. Nine subjects were exposed to smoke from a campfire in a controlled setting, and four were exposed to smoke from an older-model wood stove. All subjects were asked to provide urine samples before and after exposure, and to wear personal particulate matter with a diameter of < or =2.5 microm (PM(2.5)) monitors during exposure. Urinary levoglucosan measurements from both studies showed no consistent response to the smoke exposure. A third experiment was conducted to assess the contribution of dietary factors to urinary levoglucosan levels. Nine subjects were asked to consume caramel and provide urine samples before and after consumption. Urinary levoglucosan levels increased within 2 h of caramel consumption and returned to pre-exposure levels within 24 h. These studies suggest that diet is a major factor in determining urinary levoglucosan levels and that recent dietary history needs to be taken into account for future work involving levoglucosan as a biomarker of wood smoke exposure.
authors.affiliation: Department of Chemistry, The University of Montana, Missoula, Montana 59801, USA.
authors.forename: Megan A
authors.initials: MA
authors.lastname: Bergauff
authors.forename: Tony J
authors.initials: TJ
authors.lastname: Ward
authors.forename: Curtis W
authors.initials: CW
authors.lastname: Noonan
authors.forename: Christopher T
authors.initials: CT
authors.lastname: Migliaccio
authors.forename: Christopher D
authors.initials: CD
authors.lastname: Simpson
authors.forename: Ashley R
authors.initials: AR
authors.lastname: Evanoski
authors.forename: Christopher P
authors.initials: CP
authors.lastname: Palmer
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000652:urine; D004032:Diet; D004781:Environmental Exposure / Q000032:analysis*; D005260:Female; D005947:Glucose / Q000031:analogs & derivatives* / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D052638:Particulate Matter / Q000032:analysis; D012906:Smoke; D014934:Wood; D055815:Young Adult
chemical_list: D015415:Biomarkers; D052638:Particulate Matter; D012906:Smoke; C014989:1,6-anhydro-beta-glucopyranose; D005947:Glucose
references.citation: J Expo Sci Environ Epidemiol. 2009 May;19(4):349-58
references.pmid: 18446186
references.citation: Inhal Toxicol. 2007 Jan;19(1):67-106
references.pmid: 17127644
references.citation: Environ Sci Technol. 2007 May 15;41(10):3481-7
references.pmid: 17547167
references.citation: Am J Respir Crit Care Med. 2006 Mar 15;173(6):667-72
references.pmid: 16424447
references.citation: Environ Sci Technol. 2005 Dec 1;39(23):9049-56
references.pmid: 16382924
references.citation: Clin Chim Acta. 1986 Aug 30;159(1):11-6
references.pmid: 3757263
references.citation: J Chromatogr A. 1999 Jun 4;844(1-2):283-93
references.pmid: 10399331
references.citation: Scand J Work Environ Health. 2003 Aug;29(4):251-60
references.pmid: 12934718
references.citation: Environ Sci Technol. 2002 Jun 1;36(11):2281-95
references.pmid: 12075778
references.citation: Int J Hyg Environ Health. 2007 May;210(3-4):229-38
references.pmid: 17157561
references.citation: J Agric Food Chem. 1977 Mar-Apr;25(2):310-20
references.pmid: 838966
references.citation: J Air Waste Manag Assoc. 2006 Dec;56(12):1669-78
references.pmid: 17195486
references.citation: Ann Allergy Asthma Immunol. 2003 Oct;91(4):346-53
references.pmid: 14582813
references.citation: Environ Health Perspect. 2009 Jan;117(1):74-9
references.pmid: 19165390
references.citation: Environ Sci Technol. 2001 Jul 1;35(13):2665-75
references.pmid: 11452590
references.citation: Environ Sci Technol. 2005 Oct 15;39(20):419A-423A
references.pmid: 16295833
references.citation: Indoor Air. 2008 Oct;18(5):408-15
references.pmid: 18665872
references.citation: Sci Total Environ. 2008 Aug 25;402(1):139-46
references.pmid: 18511108
references.citation: Environ Res. 2003 Jan;91(1):21-8
references.pmid: 12550084
references.citation: Environ Res. 2001 Feb;85(2):145-58
references.pmid: 11161664
references.citation: Environ Sci Technol. 2002 Apr 1;36(7):1442-51
references.pmid: 11999049
references.citation: Environ Sci Technol. 2006 Apr 1;40(7):2163-70
references.pmid: 16646448