Convulsant activity of sitafloxacin and its interactions with anti-inflammatory drugs in mice.
We studied the convulsant activity of sitafloxacin, a newly developed quinolone, and its interaction with anti-inflammatory drugs in mice. Intraventricular injections of sitafloxacin and levofloxacin induced convulsions dose-dependently in the mice. The value of the effective dose for producing convulsions in 50% of the mice (ED(50)) of sitafloxacin was 50.6 nmol/head, whereas that of levofloxacin was 76.7 nmol/head. The convulsant activity of these quinolones was not affected by concurrent administration with anti-inflammatory drugs. From these results obtained in a mouse model, it is suggested that sitafloxacin has weak convulsant activity and that the convulsant activity of sitafloxacin is not enhanced when it is administered with anti-inflammatory drugs.
Hori
Seiji
S
Department of Pharmacology, Jikei University School of Medicine, 3-25-8 Nishi-Shinbashi, Minato-ku, Tokyo, 105-8461, Japan. horis@jikei.ac.jp
D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000009:adverse effects*; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D024841:Fluoroquinolones / Q000008:administration & dosage / Q000009:adverse effects*; D007276:Injections, Intraventricular; D064704:Levofloxacin; D051379:Mice; D015242:Ofloxacin / Q000008:administration & dosage / Q000009:adverse effects; D012640:Seizures / Q000139:chemically induced*
D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D024841:Fluoroquinolones; D064704:Levofloxacin; C076246:sitafloxacin; D015242:Ofloxacin