title: Automated two column generator systems for medical radionuclides.
abstract: This work describes automated chromatographic methods for the separation of medically useful radionuclides from source material containing their parent radionuclides. The separation techniques employ two chromatographic columns to ensure high chemical and radiochemical purity of the product radionuclide. The separations were performed using an automated system, the automated radionuclide separator (ARS2), consisting of syringe pumps and multiport valves controlled through a computer interface. Generator systems for (68)Ga, (99m)Tc, (188)Re and (213)Bi will be described.
authors.affiliation: PG Research Foundation Inc, Lisle, IL 60532, USA. dmcalister@pgrf.com
authors.forename: Daniel R
authors.initials: DR
authors.lastname: McAlister
authors.forename: E
authors.initials: E
authors.lastname: Philip Horwitz
mesh_terms: D002845:Chromatography / Q000295:instrumentation*; D045424:Complex Mixtures / Q000302:isolation & purification*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D044085:Microfluidics / Q000295:instrumentation*; D011868:Radioisotopes / Q000302:isolation & purification*; D012371:Robotics / Q000295:instrumentation*; D013594:Syringes
chemical_list: D045424:Complex Mixtures; D011868:Radioisotopes