title: New data favouring that neurotrophins are of importance in arthritis.
abstract: Neurotrophins are important in inflammation. In an article in Arthritis Research & Therapy, Barthel and collaborators give new information on the existence of neurotrophin production in the synovial tissue of arthritic joints. These findings, together with other recent findings, stress that neurotrophins should be considered important factors in arthritis. This is reinforced by the facts that they are also produced by articular chondrocytes and that receptors for these are present in the synovial tissue and on chondrocytes. The importance of neurotrophins in joints should be further studied, including examinations on the efficacy of interfering with their effects in arthritis.
authors.forename: Sture
authors.initials: S
authors.lastname: Forsgren
mesh_terms: D001172:Arthritis, Rheumatoid / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D009414:Nerve Growth Factors / Q000378:metabolism*; D013583:Synovial Membrane / Q000378:metabolism*
chemical_list: D009414:Nerve Growth Factors
references.citation: Ann N Y Acad Sci. 2006 Jun;1069:438-43
references.pmid: 16855171
references.citation: Arthritis Res Ther. 2009;11(3):R82
references.pmid: 19490633
references.citation: Scand J Rheumatol. 2009 May-Jun;38(3):207-15
references.pmid: 19177265
references.citation: Cells Tissues Organs. 2008;188(3):299-309
references.pmid: 18349525
references.citation: Clin Rheumatol. 2008 Oct;27(10):1289-97
references.pmid: 18484150
references.citation: Ann Rheum Dis. 2005 Jan;64(1):13-20
references.pmid: 15608299
references.citation: Pharmacol Res. 2008 Apr;57(4):253-8
references.pmid: 18329283
references.citation: Clin Exp Rheumatol. 2003 Sep-Oct;21(5):617-24
references.pmid: 14611111
references.citation: Ann Rheum Dis. 2005 Nov;64(11):1542-9
references.pmid: 15817657
references.citation: J Orthop Res. 2008 Jul;26(7):957-64
references.pmid: 18302239