title: The slender phenotype of pea is deficient in DELLA proteins.
abstract: The recent cloning of the pea genes LA and CRY has historical implications, since the combined effect of null mutations in these genes is the elongated, gibberellin-insensitive "slender" phenotype, which gave rise to the theory that gibberellins (GAs) are inhibitors of inhibitors of growth. Interestingly, the duplication event that produced the second gene (LA or CRY) appears to have occurred more than 100 mya, and yet the two genes have retained essentially similar functions. They both encode DELLA proteins, which inhibit growth while at the same time promoting the synthesis of the growth-promoting hormone, gibberellin (GA). This duality of function is discussed in the context of recent suggestions that DELLAs integrate multiple hormone signals, rather than just the GA signal. We also present new data showing that LA and CRY play a major role in regulating fruit growth.
authors.affiliation: School of Plant Science; University of Tasmania; Hobart; Tasmania; Australia.
authors.forename: John J
authors.initials: JJ
authors.lastname: Ross
authors.forename: James B
authors.initials: JB
authors.lastname: Reid
authors.forename: Ian C
authors.initials: IC
authors.lastname: Murfet
authors.forename: Diana E
authors.initials: DE
authors.lastname: Weston
references.citation: Plant Physiol. 1997 Sep;115(1):123-128
references.pmid: 12223795
references.citation: Plant Cell. 2001 May;13(5):999-1010
references.pmid: 11340177
references.citation: Symp Soc Exp Biol. 1957;11:166-82
references.pmid: 13486469
references.citation: J Plant Growth Regul. 2001 Dec;20(4):336-353
references.pmid: 11986760
references.citation: Plant Cell. 2003 Dec;15(12):2816-25
references.pmid: 14615596
references.citation: Nature. 2003 Feb 13;421(6924):740-3
references.pmid: 12610625
references.citation: Bioessays. 1998 Dec;20(12):1001-8
references.pmid: 10048300
references.citation: Plant Physiol. 2002 May;129(1):191-200
references.pmid: 12011350
references.citation: Curr Opin Plant Biol. 2005 Apr;8(2):122-8
references.pmid: 15752990
references.citation: J Exp Bot. 2008;59(3):585-93
references.pmid: 18250077
references.citation: Annu Rev Plant Physiol Plant Mol Biol. 2001 Jun;52:67-88
references.pmid: 11337392
references.citation: Plant Physiol. 1992 Sep;100(1):88-94
references.pmid: 16653006
references.citation: Science. 2006 Jan 6;311(5757):91-4
references.pmid: 16400150
references.citation: Annu Rev Plant Biol. 2004;55:197-223
references.pmid: 15377219
references.citation: Plant Cell. 2007 Oct;19(10):3037-57
references.pmid: 17933900
references.citation: Plant Physiol. 2008 May;147(1):199-205
references.pmid: 18375599
references.citation: Plant Physiol. 1993 Mar;101(3):759-764
references.pmid: 12231727
references.citation: Plant Cell. 2008 Feb;20(2):320-36
references.pmid: 18310462
references.citation: Plant Cell. 2001 Jul;13(7):1555-66
references.pmid: 11449051