Convenient solution-phase synthesis and conformational studies of novel linear and cyclic alpha,beta-alternating peptoids.
The synthesis of a novel family of peptidomimetics composed of linear and cyclic alpha,beta-alternating peptoids is described. Oligomers consisting of up to six peptoid residues (n = 1-3) were synthesized on large scale with use of an efficient iterative solution-phase method and longer oligomers (n = 4, 5) were obtained by the coupling of appropriately protected shorter oligomers. Preliminary conformational studies of these hybrid peptoids are reported.
Hjelmgaard
Thomas
T
Clermont Université, Université Blaise Pascal, Laboratoire SEESIB (UMR 6504-CNRS), 24 avenue des Landais, 63177 Aubière cedex, France.
Faure
Sophie
S
Caumes
Cécile
C
De Santis
Emiliana
E
Edwards
Alison A
AA
Taillefumier
Claude
C
D000595:Amino Acid Sequence; D008969:Molecular Sequence Data; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000737:chemistry*; D034444:Peptoids / Q000737:chemistry*; D011487:Protein Conformation; D055672:Static Electricity
D010456:Peptides, Cyclic; D034444:Peptoids