title: Keloid treatment: is there a role for acellular human dermis (Alloderm)?
abstract: BACKGROUND
  Keloid management is faced with high recurrence rates. Keloid fibroblasts lack the normal negative feedback mechanism resulting in an exuberant scar formation. Alloderm doesn't undergo the same proliferative process as keloidal scar dermis.
  
  
  OBJECTIVE
  To evaluate Alloderm as a treatment modality for keloids
  
  
  METHODS
  A retrospective chart review of six patients with a total of eight large recurrent keloids was performed. Patients were treated with excision of the keloid followed by placement of Alloderm. Each patient was evaluated for recurrence and complications.
  
  
  RESULTS
  During follow-up ranging from 1 month to 4(1/2) years there were 0% recurrences. Two out of 8 (25%) had residual induration. one of the two patients with residual induration, required an intralesional injection of kenalog at 6 months post-op.
  
  
  CONCLUSIONS
  Our results from this small study show that with the use of Alloderm after keloid excision, recurrence is low. Further study is warranted.
authors.affiliation: Summa Health System/Northeast Ohio Universities College of Medicine, Division of Plastic and Reconstructive Surgery, Akron, Ohio 44304, USA. illin79@aol.com
authors.forename: Nima P
authors.initials: NP
authors.lastname: Patel
authors.forename: A
authors.initials: A
authors.lastname: Lawrence Cervino
mesh_terms: D002648:Child; D003094:Collagen / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D015552:Injections, Intralesional; D007627:Keloid / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D019651:Plastic Surgery Procedures / Q000379:methods*; D012189:Retrospective Studies; D017768:Skin, Artificial; D013997:Time Factors; D016896:Treatment Outcome; D014222:Triamcinolone Acetonide / Q000008:administration & dosage; D055815:Young Adult
chemical_list: C440568:Alloderm; D005938:Glucocorticoids; D003094:Collagen; D014222:Triamcinolone Acetonide