Delivery of recombinant bone morphogenetic proteins for bone regeneration and repair. Part B: Delivery systems for BMPs in orthopaedic and craniofacial tissue engineering.
Localized and release-controlled delivery systems for the sustained expression of the biologic potency of rhBMPs are essential. A substantial number of biomaterials have been investigated thus far. Most fail after implantation or administration mainly due to either being too soft, difficult to control and/or stabilize mechanically. In the second part of this review, we review a representative selection of rhBMP-2 and rhBMP-7 carrier materials and delivery systems ranging from simple nano/microparticles to complex 3-D scaffolds in sites of orthopaedic and craniofacial bone regeneration and repair.
Haidar
Ziyad S
ZS
Faculty of Dentistry, McGill University, 740 Rue Dr. Penfield Suite # 4300, Montréal, QC, H3A 1A4, Canada.
Hamdy
Reggie C
RC
Tabrizian
Maryam
M
D001847:Bone Diseases / Q000628:therapy*; D055396:Bone Morphogenetic Protein 2 / Q000008:administration & dosage* / Q000235:genetics / Q000627:therapeutic use; D055419:Bone Morphogenetic Protein 7 / Q000008:administration & dosage* / Q000235:genetics / Q000627:therapeutic use; D001861:Bone Regeneration / Q000502:physiology*; D019465:Craniofacial Abnormalities / Q000628:therapy*; D003692:Delayed-Action Preparations / Q000627:therapeutic use; D006801:Humans; D053758:Nanoparticles; D019637:Orthopedic Procedures / Q000379:methods*; D011994:Recombinant Proteins / Q000008:administration & dosage* / Q000235:genetics / Q000627:therapeutic use
C525718:BMP2 protein, human; D055396:Bone Morphogenetic Protein 2; D055419:Bone Morphogenetic Protein 7; D003692:Delayed-Action Preparations; D011994:Recombinant Proteins