title: Oral cavity squamous cell carcinoma in 260 patients aged 80years or more.
abstract: OBJECTIVE
  We report the experience of two French cancer centers in the treatment of oral cavity squamous cell carcinoma (SCC) in patients aged 80 years.
  
  
  METHODS
  Two hundred and sixty patients aged 80 years with a primary oral cavity SCC were included in this retrospective analysis.
  
  
  RESULTS
  Sex ratio was near to 1. Tobacco or alcohol intoxication was the main risk factor for 66% of men and 16% of women and leukoplakia, lichen planus, or oral traumatism for 55% of women and 11% of men (p<0.0001). Two hundred patients received a loco-regional (LR) treatment with a curative intent (surgery and/or radiotherapy), 29 with a palliative intent and 31 did not receive a LR treatment. Curative treatments were initially planned to be adapted to age in 118 patients (59%). The median disease-specific survival (DSS) was 29 months. In multivariate analysis, the independent prognostic factors for DSS were stage (HR=0.42 [0.24-0.72]), age (HR=0.43 [0.24-0.75]) and performance status (HR=0.50 [0.27-0.95]). The median overall survival (OS) was 14 months. In multivariate analysis, the independent prognostic factors for OS were age (HR=0.52 [0.35-0.79]), stage (HR=0.56 [0.38-0.84]), tumor differentiation (HR=0.60 [0.33-0.93]) and performance status (HR=0.6 [0.37-0.97]). In patients treated with a curative intent, treatment adapted to age was not associated with a decreased overall survival or disease-specific survival as compared with the standard treatment. However, prophylactic lymph node treatment in stages I-II tumors decreased the rate of nodal recurrence from 38% to 6% (p=0.01).
  
  
  CONCLUSIONS
  This study emphasizes the need for prospective evaluation of standard and adapted schedules in elderly patients with oral cavity cancer.
authors.affiliation: Department of Radiotherapy, Centre Antoine-Lacassagne, Nice, France. c.ortholan@wanadoo.fr
authors.forename: Cécile
authors.initials: C
authors.lastname: Ortholan
authors.forename: Antoine
authors.initials: A
authors.lastname: Lusinchi
authors.forename: Antoine
authors.initials: A
authors.lastname: Italiano
authors.forename: René-Jean
authors.initials: RJ
authors.lastname: Bensadoun
authors.forename: Anne
authors.initials: A
authors.lastname: Auperin
authors.forename: Gilles
authors.initials: G
authors.lastname: Poissonnet
authors.forename: Alexandre
authors.initials: A
authors.lastname: Bozec
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Arriagada
authors.forename: Stéphane
authors.initials: S
authors.lastname: Temam
authors.forename: Karen
authors.initials: K
authors.lastname: Benezery
authors.forename: Juliette
authors.initials: J
authors.lastname: Thariat
authors.forename: Yungan
authors.initials: Y
authors.lastname: Tao
authors.forename: François
authors.initials: F
authors.lastname: Janot
authors.forename: Gérard
authors.initials: G
authors.lastname: Mamelle
authors.forename: Jacques
authors.initials: J
authors.lastname: Vallicioni
authors.forename: Philippe
authors.initials: P
authors.lastname: Follana
authors.forename: Frédéric
authors.initials: F
authors.lastname: Peyrade
authors.forename: Anne
authors.initials: A
authors.lastname: Sudaka
authors.forename: Jean
authors.initials: J
authors.lastname: Bourhis
authors.forename: Olivier
authors.initials: O
authors.lastname: Dassonville
mesh_terms: D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000209:etiology / Q000401:mortality / Q000532:radiotherapy* / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D009062:Mouth Neoplasms / Q000209:etiology / Q000401:mortality / Q000532:radiotherapy* / Q000601:surgery; D010166:Palliative Care; D012307:Risk Factors; D015996:Survival Rate