title: Tissue proteomics in atherosclerosis: elucidating the molecular mechanisms of cardiovascular diseases.
abstract: Atherosclerosis is a disease with higher levels of mortality in developed countries. Comprehension of the molecular mechanisms can yield very useful information in clinics for prevention, diagnosis and recovery monitoring. Proteomics represents an ideal methodology for this purpose, as proteins constitute the effectors of the different biological processes running during pathogenesis. To date, studies in atherosclerosis have been mainly focused on the search for plasma biomarkers. However, tissue proteomics allows going deeper into tissue secretomes, arterial layers or particular cells of interest, which, in turn, constitutes a more direct approximation to in vivo operating mechanisms. The aim of this review is to report latest advances in tissue proteomics in atherosclerosis and related diseases (e.g., aortic stenosis and ischemic injury).
authors.affiliation: Department of Immunology, Fundacion Jimenez Diaz, Avenida Reyes Catolicos 2, 28040, Madrid, Spain.
authors.forename: Fernando
authors.initials: F
authors.lastname: de la Cuesta
authors.forename: Gloria
authors.initials: G
authors.lastname: Alvarez-Llamas
authors.forename: Felix
authors.initials: F
authors.lastname: Gil-Dones
authors.forename: Tatiana
authors.initials: T
authors.lastname: Martin-Rojas
authors.forename: Irene
authors.initials: I
authors.lastname: Zubiri
authors.forename: Carlos
authors.initials: C
authors.lastname: Pastor
authors.forename: Maria G
authors.initials: MG
authors.lastname: Barderas
authors.forename: Fernando
authors.initials: F
authors.lastname: Vivanco
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000378:metabolism* / Q000473:pathology; D002318:Cardiovascular Diseases / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D040901:Proteomics