Trypanosoma cruzi circulating in the southern region of the State of Mexico (Zumpahuacan) are pathogenic: a dog model.
Here we describe clinical and pathologic evidence of Chagas disease caused in dogs by circulating Trypanosoma cruzi from a newly recognized endemic area in Mexico. We show that the Zumpahuacan isolate, although less virulent than the Sylvio-X10 reference strain that caused acute myocarditis and death, was pathogenic in dogs. Dogs infected with the Zumpahuacan isolate exhibited electrocardiographic alterations, left- and right-ventricle dilation, and hydropericardium. Histologically, diffused perimysial and endomysial lymphoplasmacytic cell infiltration, cardiomyocyte necrosis, and amastigote nests were noted in Zumpahuacan-infected dogs. These findings suggest that the risk of T. cruzi infection and Chagas disease is present in the State of Mexico, and further research is needed to identify the T. cruzi bio-types circulating in southern State of Mexico.
Barbabosa-Pliego
Alberto
A
Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma del Estado de México, Toluca, México.
Díaz-Albiter
Hector M
HM
Ochoa-García
Laucel
L
Aparicio-Burgos
Esteban
E
López-Heydeck
Sandra M
SM
Velásquez-Ordoñez
Valente
V
Fajardo-Muñoz
Raul C
RC
Díaz-González
Sandra
S
De Oca-Jimenez
Roberto Montes
RM
Barbosa-Mireles
Marco
M
Guzmán-Bracho
Carmen
C
Estrada-Franco
Jose G
JG
Garg
Nisha Jain
NJ
Vázquez-Chagoyán
Juan C
JC
D000818:Animals; D002598:Chagas Cardiomyopathy / Q000453:epidemiology / Q000469:parasitology / Q000662:veterinary; D014355:Chagas Disease / Q000453:epidemiology / Q000469:parasitology / Q000473:pathology / Q000662:veterinary*; D004195:Disease Models, Animal; D004197:Disease Reservoirs / Q000662:veterinary; D004283:Dog Diseases / Q000453:epidemiology / Q000469:parasitology* / Q000473:pathology; D004285:Dogs; D008800:Mexico / Q000453:epidemiology; D051379:Mice; D008807:Mice, Inbred BALB C; D009206:Myocardium / Q000473:pathology; D014349:Trypanosoma cruzi / Q000472:pathogenicity*; D014774:Virulence
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