Phylogenetic analysis of rubella viruses isolated in 2008 outbreak in Argentina.
BACKGROUND
A rubella outbreak was recorded in Buenos Aires during 2008.


OBJECTIVE
The objective of this communication is to present the genetic and phylogenetic analyses of wild-type RUBV circulating in Buenos Aires during the 2008 outbreak.


METHODS
Throat swab samples collected from patients diagnosed with rubella between June 2008 and December 2008 were inoculated in cell culture and 23 isolates were sequenced.


RESULTS
Phylogenetic analysis of the WHO-recommended window (nt 8731-9469) of the E1 envelope glycoprotein was performed and all isolates clustered with the 2B genotype.


CONCLUSIONS
Genotype 2B seems to be endemically circulating in the Southern cone of Latin America, thus causing recent outbreaks.
Valinotto
Laura E
LE
Laboratorio de Virología, Hospital de Niños R. Gutiérrez, Buenos Aires, Argentina.
Viegas
Mariana
M
Acevedo
María Elina
ME
Barrero
Paola R
PR
Mistchenko
Alicia S
AS
D000293:Adolescent; D000328:Adult; D000595:Amino Acid Sequence; D001118:Argentina / Q000453:epidemiology; D002648:Child; D019143:Evolution, Molecular; D006801:Humans; D017720:Molecular Epidemiology / Q000379:methods; D010614:Pharynx / Q000821:virology; D010802:Phylogeny; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012409:Rubella / Q000453:epidemiology / Q000821:virology*; D012412:Rubella virus / Q000235:genetics* / Q000302:isolation & purification; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA