title: Structural and pharmacological features of phospholipases A2 from snake venoms.
abstract: Phospholipases A(2) enzymes are found in many biological sources, including snake venoms. Here we reviewed aspects of PLA(2)s including biological and structural features, interaction with binding receptors, inhibitors used on structure-function relationship studies and highlighting the mechanism of action and role of the snake venom PLA(2)s products, the lysophosphatidylcholine.
authors.affiliation: Departamento de Biologia Celular e Molecular, Instituto de Biologia, Universidade Federal Fluminense, Niterói, RJ, Brasil.
authors.forename: Rafael Cisne
authors.initials: RC
authors.lastname: de Paula
authors.forename: Helena Carla
authors.initials: HC
authors.lastname: Castro
authors.forename: Carlos Rangel
authors.initials: CR
authors.lastname: Rodrigues
authors.forename: Paulo Assis
authors.initials: PA
authors.lastname: Melo
authors.forename: André Lopes
authors.initials: AL
authors.lastname: Fuly
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D064801:Phospholipase A2 Inhibitors; D054467:Phospholipases A2 / Q000737:chemistry* / Q000494:pharmacology*; D016415:Sequence Alignment; D012910:Snake Venoms / Q000201:enzymology*; D012911:Snakes
chemical_list: D064801:Phospholipase A2 Inhibitors; D012910:Snake Venoms; D054467:Phospholipases A2