title: Correlation of serum and salivary CA15-3 levels in patients with breast cancer.
abstract: OBJECTIVE
  The aim of this study was to assess the relationship between serum and saliva levels of cancer antigen (CA) 15-3 and to compare them between women with and without breast cancer.
  
  
  METHODS
  A case-control study was carried out on 61 women aged 28-69 years, including women with and without breast cancer (26 as part of the case study and 35 as part of the control group) conducted at the Emam Khomeini Hospital, Tehran University of Medical Sciences. CA 15-3 levels were assayed in serum and unstimulated whole saliva by EIA. Unpaired t-test, one-way ANOVA and Pearson correlation were used as statistical analysis.
  
  
  RESULTS
  The salivary and serological levels of CA 15-3 in the cancer patients were significantly higher (P <0.01) than the salivary and serum levels of healthy controls. They were also higher in stage 2 than in stage 1 in cancer patients. However, the saliva flow rate was significantly lower in the cancer patients (P <0.01). There was a significant positive correlation between serum and saliva CA 15-3 concentration (r = 0.614) and also between serum concentration and saliva output of CA 15-3 (r = 0.541).
  
  
  CONCLUSIONS
  The results of the study suggest that salivary CA 15-3 may have potential use in the initial detection of breast cancer in women.
authors.affiliation: Department of Oral Medicine, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran. aghahose@sina.tums.ac.ir
authors.forename: Farzaneh
authors.initials: F
authors.lastname: Agha-Hosseini
authors.forename: Iraj
authors.initials: I
authors.lastname: Mirzaii-Dizgah
authors.forename: Asieh
authors.initials: A
authors.lastname: Rahimi
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000097:blood / Q000378:metabolism*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008875:Middle Aged; D018396:Mucin-1 / Q000032:analysis*; D012463:Saliva / Q000737:chemistry*
chemical_list: D018396:Mucin-1