title: CO(2) laser therapy in Tis and T1 glottic cancer: indications and results.
abstract: BACKGROUND
  Laser cordectomy for glottic cancer is still hampered by recurrence, which is more frequent upon anterior commissure (AC) involvement. Analysis of results may be a step to improve the efficacy of this therapy for early glottic cancer.
  
  
  METHODS
  In all, 81 patients who underwent surgery with CO(2) laser for Tis and T1, AC0 to AC2 glottic carcinoma were followed up to 55 months.
  
  
  RESULTS
  The incidence of recurrence increased significantly with T and AC classifications. The disease-free interval decreased with increasing T and AC classifications and with increasing severity of histology, but only the AC classification appeared significant. Recurrences occurred in 5 of 35 patients upon type I and type II cordectomy, in 16 of 24 patients upon type V cordectomy, and never upon type III and IV cordectomy.
  
  
  CONCLUSIONS
  Type I to type IV cordectomy, when indicated, can achieve radical treatment of most T1 glottic cancer. Type V cordectomy requires that any suspicion of cartilage invasion, even microscopic, be excluded.
authors.affiliation: Department of Oto-Neuro-Ophthalmological Surgical Sciences, Division of Otorhinolaryngology-Head and Neck Surgery, University of Florence, Florence, Italy. lucio.rucci@unifi.it
authors.forename: Lucio
authors.initials: L
authors.lastname: Rucci
authors.forename: Paolo
authors.initials: P
authors.lastname: Romagnoli
authors.forename: Jacopo
authors.initials: J
authors.lastname: Scala
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D005931:Glottis; D006801:Humans; D053208:Kaplan-Meier Estimate; D007822:Laryngeal Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D053685:Laser Therapy; D054020:Lasers, Gas / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D012189:Retrospective Studies; D016896:Treatment Outcome