title: Regulatory T cells that become autoaggressive.
abstract: Foxp3 expression is not stable and may be extinguished both in vitro and in vivo in regulatory T cells that convert into proinflammatory effector T cells. The loss of Foxp3 in regulatory T cells under autoimmune conditions may result in the conversion of suppressor T cells into highly autoaggressive lymphocytes.
authors.forename: Daniel
authors.initials: D
authors.lastname: Hawiger
authors.forename: Richard A
authors.initials: RA
authors.lastname: Flavell
mesh_terms: D000818:Animals; D015551:Autoimmunity; D051858:Forkhead Transcription Factors / Q000502:physiology*; D019426:Integrases / Q000502:physiology; D051379:Mice; D011948:Receptors, Antigen, T-Cell / Q000502:physiology; D050378:T-Lymphocytes, Regulatory / Q000502:physiology*
chemical_list: D051858:Forkhead Transcription Factors; C498833:Foxp3 protein, mouse; D011948:Receptors, Antigen, T-Cell; C045073:Cre recombinase; D019426:Integrases
references.citation: Nat Immunol. 2009 Jul;10(7):689-95
references.pmid: 19536194
references.citation: Nat Immunol. 2009 Sep;10(9):1000-7
references.pmid: 19633673
references.citation: Science. 2009 Mar 13;323(5920):1488-92
references.pmid: 19286559
references.citation: Immunity. 2009 May;30(5):626-35
references.pmid: 19464985
references.citation: Nat Immunol. 2003 Apr;4(4):330-6
references.pmid: 12612578
references.citation: Eur J Immunol. 2008 Apr;38(4):915-7
references.pmid: 18395859
references.citation: Nat Immunol. 2007 Mar;8(3):277-84
references.pmid: 17220892
references.citation: Nature. 2007 Feb 15;445(7129):771-5
references.pmid: 17220874
references.citation: Immunity. 2009 May;30(5):646-55
references.pmid: 19464987
references.citation: J Clin Immunol. 2008 Nov;28(6):619-24
references.pmid: 18841451
references.citation: Annu Rev Immunol. 2004;22:531-62
references.pmid: 15032588