Chronic prenatal caffeine exposure impairs novel object recognition and radial arm maze behaviors in adult rats.
In this report, we demonstrate that chronic prenatal exposure to a moderate dose of caffeine disrupts novel object recognition and radial arm maze behaviors in adult male and female rats. Pregnant dams were administered either tap water or 75 mg/L caffeinated tap water throughout gestation. Oral self-administration in the drinking water led to an approximate maternal intake of 10mg/kg/day, equivalent to 2-3 cups of coffee/day in humans based on a metabolic body weight conversion. In adulthood, the offspring underwent testing on novel object recognition, radial arm maze, and Morris water maze tasks. Prenatal caffeine exposure was found to impair 24-h memory retention in the novel object recognition task and impair both working and reference memory in the radial arm maze. However, prenatal caffeine exposure did not alter Morris water maze performance in either a simple water maze procedure or in an advanced water maze procedure that included reversal and working memory paradigms. These findings demonstrate that chronic oral intake of caffeine throughout gestation can alter adult cognitive behaviors in rats.
Soellner
Deborah E
DE
Neuroscience Program, Michigan State University, East Lansing, MI 48824, USA. soellner@msu.edu
Grandys
Theresa
T
Nuñez
Joseph L
JL
D000818:Animals; D002110:Caffeine / Q000008:administration & dosage / Q000009:adverse effects*; D000697:Central Nervous System Stimulants / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D007859:Learning Disabilities / Q000139:chemically induced*; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008569:Memory Disorders / Q000139:chemically induced*; D008570:Memory, Short-Term / Q000187:drug effects; D009483:Neuropsychological Tests; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D021641:Recognition, Psychology / Q000187:drug effects; D012193:Reversal Learning / Q000187:drug effects
D000697:Central Nervous System Stimulants; D002110:Caffeine
Semin Perinatol. 1981 Oct;5(4):310-4
7302604
Brain Res Dev Brain Res. 1996 Jul 20;94(2):205-23
8836580
Eur J Pharmacol. 2005 Feb 21;509(2-3):155-9
15733550
Neuroscience. 2008 Oct 15;156(3):630-9
18706486
J Pediatr. 1981 Apr;98(4):640-1
7205496
Life Sci. 1986 Mar 10;38(10):861-8
3951312
J Neurochem. 2002 Aug;82(3):625-34
12153486
Behav Pharmacol. 1993 Oct;4(5):541-544
11224223
Neuroscience. 1987 Sep;22(3):827-39
2825071
Synapse. 2005 Jul;57(1):8-16
15858837
J Neurochem. 2005 Jul;94(2):440-51
15998294
Behav Brain Res. 1988 Nov 1;31(1):47-59
3228475
Brain Res Mol Brain Res. 1993 Dec;20(4):313-27
8114618
Brain Res Dev Brain Res. 1993 Oct 15;75(2):193-9
8261611
Synapse. 1997 Dec;27(4):322-35
9372555
Arch Dis Child. 1979 Dec;54(12):946-9
533298
Neurosci Lett. 1987 Oct 16;81(1-2):69-74
3696476
Paediatr Perinat Epidemiol. 2003 Oct;17(4):324-31
14629313
Behav Brain Res. 1992 Oct 31;51(1):83-92
1482548
Pharmacol Rev. 1999 Mar;51(1):83-133
10049999
Prog Neurobiol. 1999 Nov;59(4):355-96
10501634
Physiol Behav. 1987;40(6):793-7
3313453
Cell Mol Life Sci. 2004 Apr;61(7-8):857-72
15095008
Neurotoxicol Teratol. 1991 Nov-Dec;13(6):641-7
1779952
J Pediatr. 1977 Mar;90(3):467-72
14241
J Neurosci Methods. 1984 May;11(1):47-60
6471907
Neuroreport. 2002 Jul 2;13(9):1199-204
12151769
Pharmacol Biochem Behav. 1991 Aug;39(4):883-8
1763107
Peptides. 1990 Sep-Oct;11(5):927-32
2284203
Eur J Clin Pharmacol. 1981;21(2):121-6
7341280
Synapse. 2006 Nov;60(6):450-5
16892188
Neurotoxicol Teratol. 1994 Nov-Dec;16(6):531-43
7862054
Mol Genet Metab. 2001 Sep-Oct;74(1-2):160-71
11592813
Neurobiol Learn Mem. 2007 Jan;87(1):42-56
16824773
PLoS One. 2008;3(12):e3977
19092996
J Appl Toxicol. 1982 Dec;2(6):307-14
7185911
Psychopharmacology (Berl). 2007 Mar;191(1):119-25
17096081
Pediatr Res. 2000 Aug;48(2):177-83
10926292
Neuropharmacology. 1991 May;30(5):489-96
1865995
Biol Neonate. 1987;51(6):332-9
3607108
Behav Brain Res. 2005 May 7;160(1):99-106
15836904
Brain Dev. 1984;6(4):355-61
6496872
Annu Rev Neurosci. 2001;24:31-55
11283304
Dev Pharmacol Ther. 1983;6(5):315-22
6628163
Brain Res Dev Brain Res. 1997 Jan 2;98(1):145-9
9027414
Toxicol Lett. 1988 Nov;44(1-2):167-75
3188075
J Endocrinol. 2003 Jul;178(1):45-54
12844335