PPAR-gamma expression in peritoneal endometriotic lesions correlates with pain experienced by patients.
Endometriosis is a significant gynecologic condition that can cause both pain and infertility and affects up to 15% of women during their reproductive years. In peritoneal endometriotic lesions, the expression of peroxisome proliferation-activated receptor gamma, a nuclear receptor with antiinflammatory and neuroprotective roles, is positively correlated with the pain reported by patients.
McKinnon
Brett
B
Department of Obstetrics and Gynecology, Inselspital, Berne University Hospital, University of Berne, Berne, Switzerland. brett.mckinnon@dkf.unibe.ch
Bersinger
Nick A
NA
Huber
Alexander W
AW
Kuhn
Annette
A
Mueller
Michael D
MD
D004412:Dysmenorrhea / Q000209:etiology / Q000378:metabolism; D004414:Dyspareunia / Q000209:etiology / Q000378:metabolism; D004715:Endometriosis / Q000150:complications / Q000378:metabolism* / Q000601:surgery; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D010535:Laparoscopy; D047495:PPAR gamma / Q000032:analysis*; D010147:Pain Measurement; D017699:Pelvic Pain / Q000209:etiology* / Q000378:metabolism*; D010532:Peritoneal Diseases / Q000150:complications / Q000378:metabolism* / Q000601:surgery; D012720:Severity of Illness Index
D047495:PPAR gamma