title: Mathematical modelling of the agr operon in Staphylococcus aureus.
abstract: Staphylococcus aureus is a pathogenic bacterium that utilises quorum sensing (QS), a cell-to-cell signalling mechanism, to enhance its ability to cause disease. QS allows the bacteria to monitor their surroundings and the size of their population, and S. aureus makes use of this to regulate the production of virulence factors. Here we describe a mathematical model of this QS system and perform a detailed time-dependent asymptotic analysis in order to clarify the roles of the distinct interactions that make up the QS process, demonstrating which reactions dominate the behaviour of the system at various timepoints. We couple this analysis with numerical simulations and are thus able to gain insight into how a large population of S. aureus shifts from a relatively harmless state to a highly virulent one, focussing on the need for the three distinct phases which form the feedback loop of this particular QS system.
authors.affiliation: Division of Theoretical Mechanics, School of Mathematical Sciences, University of Nottingham, Nottingham, NG7 2RD, UK. sara.jabbari@nottingham.ac.uk
authors.forename: Sara
authors.initials: S
authors.lastname: Jabbari
authors.forename: John R
authors.initials: JR
authors.lastname: King
authors.forename: Adrian J
authors.initials: AJ
authors.lastname: Koerber
authors.forename: Paul
authors.initials: P
authors.lastname: Williams
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics; D003198:Computer Simulation; D008957:Models, Genetic; D009876:Operon / Q000235:genetics*; D010456:Peptides, Cyclic; D011494:Protein Kinases / Q000235:genetics; D053038:Quorum Sensing / Q000235:genetics*; D013203:Staphylococcal Infections / Q000382:microbiology; D013211:Staphylococcus aureus / Q000235:genetics / Q000472:pathogenicity*; D037521:Virulence Factors / Q000235:genetics
chemical_list: C414533:AgrB protein, Staphylococcus aureus; C414532:AgrD protein, Staphylococcus; D001426:Bacterial Proteins; D010456:Peptides, Cyclic; D037521:Virulence Factors; D011494:Protein Kinases; C531166:AgrC protein, Staphylococcus
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