title: Lead and cognitive function in ALAD genotypes in the third National Health and Nutrition Examination Survey.
abstract: The relationship between the blood lead concentration and cognitive function in children and adults with different ALAD genotypes who participated in the third National Health and Nutrition Examination Survey was investigated. The relationship between blood lead and serum homocysteine concentrations was also investigated. In children 12 to 16 years old, no difference in the relationship between cognitive function and blood lead concentration between genotypes was found. In adults 20 to 59 years old, mean reaction time decreased as the blood lead concentration increased in the ALAD rs1800435 CC/CG group. This represents an improvement in performance. In adults 60 years and older, no difference in the relationship between cognitive function and blood lead concentration between genotypes was found. The serum homocysteine concentration increased as the blood lead concentration increased in adults 20 to 59 years old and 60 years and older, but there were no differences between genotypes. The mean blood lead concentration of children with the ALAD rs1800435 CC/CG genotype was less than that of children with the GG genotype.
authors.affiliation: National Institute for Occupational Safety and Health, Robert A. Taft Laboratories, Cincinnati, Ohio 45226, USA. erk3@cdc.gov
authors.forename: Edward F
authors.initials: EF
authors.lastname: Krieg
authors.forename: Mary Ann
authors.initials: MA
authors.lastname: Butler
authors.forename: Man-huei
authors.initials: MH
authors.lastname: Chang
authors.forename: Tiebin
authors.initials: T
authors.lastname: Liu
authors.forename: Ajay
authors.initials: A
authors.lastname: Yesupriya
authors.forename: Mary Lou
authors.initials: ML
authors.lastname: Lindegren
authors.forename: Nicole
authors.initials: N
authors.lastname: Dowling
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D003071:Cognition / Q000187:drug effects*; D004781:Environmental Exposure; D004785:Environmental Pollutants; D005260:Female; D005838:Genotype; D006710:Homocysteine / Q000097:blood; D006801:Humans; D007854:Lead / Q000097:blood / Q000633:toxicity*; D007855:Lead Poisoning / Q000097:blood / Q000235:genetics / Q000523:psychology*; D008297:Male; D011939:Mental Recall / Q000187:drug effects; D008875:Middle Aged; D009749:Nutrition Surveys; D020641:Polymorphism, Single Nucleotide; D000623:Porphobilinogen Synthase / Q000235:genetics*; D011597:Psychomotor Performance / Q000187:drug effects
chemical_list: D004785:Environmental Pollutants; D006710:Homocysteine; D007854:Lead; D000623:Porphobilinogen Synthase