title: Weight loss and body fat reduction under sibutramine therapy in obesity with the C825T polymorphism in the GNB3 gene.
abstract: The relationship between weight reduction after sibutramine treatment and a single nucleotide polymorphism, rs5443 (C825T), in the guanine nucleotide binding protein beta polypeptide 3 (GNB3) gene is currently inconsistent. In this study, we aimed to reassess whether the GNB3 rs5443 single nucleotide polymorphism could influence weight reduction and body composition change under sibutramine therapy in 131 obese Taiwanese patients. By comparing the sibutramine and placebo groups with analysis of covariance, our data showed a strong effect of sibutramine on weight reduction (7.4+/-1.4 vs. 3.4+/-1.2 kg; P<0.001) and on body fat percentage loss (4.2+/-0.1 vs. 2.1+/-0.1%; P<0.001) in the combined TT+TC carriers. In contrast, sibutramine caused no significant additional effect on weight loss (P = 0.078) or on body fat percentage loss (P = 0.441) in homozygous C allele carriers.
authors.affiliation: College of Public Health and Nutrition, Taipei Medical University, Taipei, Taiwan.
authors.forename: Dun-Jen
authors.initials: DJ
authors.lastname: Hsiao
authors.forename: Lawrence Shih-Hsin
authors.initials: LS
authors.lastname: Wu
authors.forename: Shih-Yi
authors.initials: SY
authors.lastname: Huang
authors.forename: Eugene
authors.initials: E
authors.lastname: Lin
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects*; D000293:Adolescent; D000328:Adult; D000368:Aged; D001067:Appetite Depressants / Q000627:therapeutic use*; D015992:Body Mass Index; D003503:Cyclobutanes / Q000627:therapeutic use*; D005260:Female; D020962:Heterotrimeric GTP-Binding Proteins / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000188:drug therapy* / Q000235:genetics; D010919:Placebos; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D013624:Taiwan; D015431:Weight Loss / Q000187:drug effects* / Q000235:genetics; D055815:Young Adult
chemical_list: D001067:Appetite Depressants; D003503:Cyclobutanes; C454420:G-protein beta3 subunit; D010919:Placebos; D020962:Heterotrimeric GTP-Binding Proteins; C058254:sibutramine