Infection of mosquitoes with Plasmodium falciparum by feeding on humans and on Aotus monkeys.
Of 1,004 positive lots of mosquitoes fed on 229 humans infected with Plasmodium falciparum, 46.2% had 1-10 oocysts/(+)gut, 21.2% had 10-30 oocysts/(+)gut, 22.2% had 30-100 oocysts/(+)gut, and 10.4% had > 100 oocysts/(+) gut. The highest levels of infection occurred between 6 and 15 days after the peak in the asexual parasite count. Of 2,281 lots of Anopheles freeborni mosquitoes fed on splenectomized Aotus monkeys infected with the Santa Lucia strain of P. falciparum, 1,191 were infected (52.2%). The highest intensity infections ranged from 2.78 oocysts per positive gut in mosquitoes fed on Aotus vociferans to 6.08 oocysts per positive gut for those fed on A. lemurinus griseimembra to 10.4 oocysts per positive gut for those fed on A. nancymaae. The pattern of infection for mosquitoes fed on splenectomized Aotus monkeys was similar to that obtained by feeding on humans, but the intensity, based on oocyst/(+)gut, was much lower.
Collins
William E
WE
Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, US Public Health Service, Atlanta, Georgia 30341, USA. wec1@cdc.gov
Jeffery
Geoffrey M
GM
Sullivan
Joann S
JS
Nace
Douglas
D
Williams
Tyrone
T
Galland
G Gale
GG
Williams
Allison
A
Barnwell
John W
JW
D000818:Animals; D000852:Anopheles / Q000469:parasitology*; D016645:Aotidae / Q000469:parasitology*; D006790:Host-Parasite Interactions; D006801:Humans; D007303:Insect Vectors / Q000469:parasitology*; D016778:Malaria, Falciparum / Q000635:transmission*; D008992:Monkey Diseases / Q000635:transmission*; D010963:Plasmodium falciparum / Q000502:physiology*