Influence of quaternary conformation on the biological activities of the Asp49-phospholipases A2s from snake venoms.
One of the main components of snake venoms are the Asp49-phospholipases A(2), also known as svPLA(2)s. The study of these toxins is a matter of great scientific interest due to their wide variety of biological effects. In this work we present strong evidences found in literature and other aspects which strengthen the importance of quaternary assembly for understanding the activities and molecular evolution of svPLA(2)s.
Magro
Angelo J
AJ
Departamento de Física e Biofísica, Instituto de Biociências, UNESP, Botucatu/SP, Brasil.
Fernandes
Carlos A H
CA
dos Santos
Juliana I
JI
Fontes
Marcos R M
MR
D000818:Animals; D008958:Models, Molecular; D054467:Phospholipases A2 / Q000737:chemistry* / Q000378:metabolism; D011487:Protein Conformation; D055503:Protein Multimerization; D012910:Snake Venoms / Q000201:enzymology*; D012911:Snakes
D012910:Snake Venoms; D054467:Phospholipases A2