The Key Events Dose-Response Framework: its potential for application to foodborne pathogenic microorganisms.
The Key Events Dose-Response Framework (KEDRF) is an analytical approach that facilitates the use of currently available data to gain insight regarding dose-response relationships. The use of the KEDRF also helps identify critical knowledge gaps that once filled, will reduce reliance on assumptions. The present study considers how the KEDRF might be applied to pathogenic microorganisms, using fetal listeriosis resulting from maternal ingestion of food contaminated with L. monocytogenes as an initial example. Major biological events along the pathway between food ingestion and the endpoint of concern are systematically considered with regard to dose (i.e., number of organisms), pathogen factors (e.g., virulence), and protective host mechanisms (e.g., immune response or other homeostatic mechanisms). It is concluded that the KEDRF provides a useful structure for systematically evaluating the complex array of host and pathogen factors that influence the dose-response relationship. In particular, the KEDRF supports efforts to specify and quantify the sources of variability, a prerequisite to strengthening the scientific basis for food safety decision making.
Buchanan
Robert L
RL
Center for Food Safety and Security Systems, University of Maryland, College Park, MD, USA.
Havelaar
Arie H
AH
Smith
Mary Alice
MA
Whiting
Richard C
RC
Julien
Elizabeth
E
D004196:Disease Outbreaks; D005260:Female; D005516:Food Microbiology; D006706:Homeostasis; D006801:Humans; D008089:Listeria monocytogenes; D008088:Listeriosis / Q000517:prevention & control*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D011634:Public Health
Microb Pathog. 2000 Sep;29(3):137-44
10968945
Mol Microbiol. 1993 Sep;9(5):931-41
7934921
J Food Prot. 1997 Aug;60(8):918-922
31207816
J Infect Dis. 2001 Sep 15;184(6):732-7
11517434
Proc Natl Acad Sci U S A. 1990 Aug;87(16):6068-72
2117270
Symp Ser Soc Appl Microbiol. 1998;27:7S-14S
9750357
Reprod Toxicol. 2008 Oct;26(2):151-5
18793713
EMBO J. 1999 Jul 15;18(14):3956-63
10406800
EMBO Rep. 2003 May;4(5):523-9
12776739
J Food Prot. 2008 May;71(5):1028-34
18522041
Risk Anal. 2002 Jun;22(3):455-63
12088225
Mol Microbiol. 1991 Feb;5(2):367-72
1645839
Infect Immun. 1997 Dec;65(12):5309-19
9393831
Foodborne Pathog Dis. 2009 Jan-Feb;6(1):57-70
19014275
Infect Immun. 1990 Apr;58(4):1048-58
2108086
Int J Food Microbiol. 2003 Aug 15;85(1-2):1-9
12810266
Appl Environ Microbiol. 1992 Dec;58(12):3991-4000
1476441
Science. 2001 Jun 1;292(5522):1722-5
11387478
J Food Prot. 1990 Dec;53(12):1003-1009
31018273
Infect Immun. 2003 Mar;71(3):1574-9
12595480
J Infect Dis. 2005 Jun 1;191(11):1889-97
15871123
J Gen Microbiol. 1957 Feb;16(1):38-58
13406218
Infect Immun. 1997 Jan;65(1):101-9
8975898
Infect Immun. 2007 Feb;75(2):950-7
17118980
Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):6152-7
15073336
Int J Food Microbiol. 1999 Sep 15;50(1-2):93-100
10488846
Mol Microbiol. 2000 Jan;35(2):289-98
10652090
Int J Food Microbiol. 2000 Jul 15;58(3):159-72
10939266
J Cell Biol. 1990 Dec;111(6 Pt 2):2979-88
2125302
J Cell Biol. 1989 Oct;109(4 Pt 1):1597-608
2507553
FEMS Immunol Med Microbiol. 2003 Apr 1;35(3):177-82
12648834
Infect Immun. 1998 Jan;66(1):232-8
9423863
Appl Environ Microbiol. 1993 Oct;59(10):3495-7
8250571
Arch Microbiol. 2008 Jul;190(1):101-4
18327567
Infect Immun. 1992 Sep;60(9):3609-19
1500169
Appl Environ Microbiol. 2007 May;73(9):2919-30
17337550
Nature. 2008 Oct 30;455(7217):1244-7
18815593
Nature. 2008 Oct 30;455(7217):1186-7
18972010
Infect Immun. 1987 Nov;55(11):2822-9
3117693
Appl Environ Microbiol. 1996 May;62(5):1693-8
8633868
Epidemiol Infect. 2008 Jun;136(6):761-70
17672927
Infect Immun. 1995 Nov;63(11):4231-7
7591052
J Exp Med. 1991 Mar 1;173(3):751-4
1847723
Proc Biol Sci. 2009 Jun 22;276(1665):2233-42
19324752
Infect Immun. 1995 Nov;63(11):4531-4
7591098
Appl Environ Microbiol. 1991 Sep;57(9):2666-70
1662937
Proc Natl Acad Sci U S A. 2005 Sep 6;102(36):12927-31
16118276
Regul Toxicol Pharmacol. 2001 Oct;34(2):146-52
11603957
Infect Immun. 2008 Feb;76(2):726-31
18070908
J Bacteriol. 1998 Jul;180(14):3650-6
9658010
FEMS Immunol Med Microbiol. 1995 Oct;12(2):143-52
8589664
Infect Immun. 1986 Jan;51(1):314-9
3079734
Infect Immun. 2005 Oct;73(10):6322-31
16177303
Infect Immun. 2003 Sep;71(9):5163-8
12933860
Proc Natl Acad Sci U S A. 1978 Mar;75(3):1534-6
306628
Foodborne Pathog Dis. 2007 Summer;4(2):222-32
17600490
Emerg Infect Dis. 1999 Sep-Oct;5(5):607-25
10511517
Am J Epidemiol. 1983 Oct;118(4):573-82
6637984
EMBO J. 1994 Feb 15;13(4):758-63
8112291
Reprod Toxicol. 2008 Oct;26(2):123-9
18708136
Infect Immun. 2004 Jun;72(6):3543-8
15155663
Appl Environ Microbiol. 2007 May;73(9):2806-14
17337561
Crit Rev Food Sci Nutr. 2009 Sep;49(8):682-9
19690994
Cell. 1992 Feb 7;68(3):521-31
1739966
Int J Food Microbiol. 2008 Mar 31;123(1-2):142-50
18258322
Lab Anim (NY). 2009 Apr;38(4):126-30
19308063
Appl Environ Microbiol. 2007 Jun;73(11):3742-6
17434996
J Food Prot. 2007 May;70(5):1122-8
17536670
Rev Infect Dis. 1987 May-Jun;9(3):488-93
3299635
J Food Prot. 2007 Jan;70(1):65-9
17265862
Risk Anal. 2004 Apr;24(2):401-7
15078310
Environ Microbiol. 2009 Feb;11(2):432-45
19196274
Infect Immun. 1995 Nov;63(11):4268-76
7591057