[Plasticity of the motor system in multiple sclerosis].
Multiple Sclerosis (MS) is associated with a chronic demyelinating and axonal injury to the central nervous system. Functional activation studies in MS patients have demonstrated that performance of simple motor tasks may activate non-canonical brain regions. Using virtual lesion induction by transcranial magnetic stimulation, it is possible to show that this activation is functionally relevant. Rapid-onset neuronal plasticity in patients with mild-to-moderate MS is uncompromised despite many plasticity-impeding factors. Long-term adaptive mechanisms, relying on the formation on new neuronal connections, most likely are the principal mechanism underlying compensation of brain injury in MS.
Classen
J
J
Klinik und Poliklinik für Neurologie, Universität Leipzig A. ö. R., Liebigstrasse 20, Leipzig. Joseph.Classen@medizin.unileipzig.de
Zeller
D
D
aufm Kampe
K
K
Dang
S
S
D004525:Efferent Pathways / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D009068:Movement / Q000502:physiology; D009103:Multiple Sclerosis / Q000473:pathology / Q000503:physiopathology*; D009434:Neural Pathways / Q000473:pathology; D009473:Neuronal Plasticity / Q000502:physiology*; D050781:Transcranial Magnetic Stimulation