title: Prediction of biochemical failure in localized carcinoma of prostate after radical prostatectomy by neuro-fuzzy.
abstract: OBJECTIVE
  To predict biochemical failure in localized prostate cancer after radical prostatectomy using preoperative variables.
  
  
  METHODS
  Twenty-six patients of early carcinoma of prostate underwent open retropubic radical prostatectomy from June 2002 to June 2006. Preoperative variables included age, family history, digital rectal examination, serum prostatic specific antigen (S. PSA), prostate biopsy Gleason score, MRI of pelvis variables like periprostatic extension, seminal vesical invasion, weight of gland and pathological stage. With application of neuro-fuzzy, these variables were fed into system as input and output, that is S. PSA at six months (predicted value) was calculated. Neuro-fuzzy system is a system to combine fuzzy system with learning techniques derived from neural networks. Here, we applied Takagi Sugeno Kang model (TSK) due to its close solution to our aim. All the patients were followed up for a minimum of six months. At six month S. PSA of all patients was done (observed value). Predicted and observed values were compared.
  
  
  RESULTS
  Predicted and observed values were plotted on 1:1 slop line. Coefficient of correlation was 0.9935.
  
  
  CONCLUSIONS
  Coefficient of correlation is close to one. It indicates that the neuro-fuzzy is accurate in predicting biochemical failure in localized carcinoma of prostate after radical prostatectomy.
authors.affiliation: Department of Urology, Institute of Medical Sciences, Banaras Hindu University, Varanasi - 221 005, India.
authors.forename: Neeraj Kumar
authors.initials: NK
authors.lastname: Goyal
authors.forename: Abhay
authors.initials: A
authors.lastname: Kumar
authors.forename: Rajiba L
authors.initials: RL
authors.lastname: Acharya
authors.forename: Udai Shankar
authors.initials: US
authors.lastname: Dwivedi
authors.forename: Sameer
authors.initials: S
authors.lastname: Trivedi
authors.forename: Pratap Bahadur
authors.initials: PB
authors.lastname: Singh
authors.forename: T N
authors.initials: TN
authors.lastname: Singh
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