title: Reclassification of leiomyosarcoma as an extra-gastrointestinal stromal tumor of the gynecologic tract.
abstract: Extra-gastrointestinal stromal tumors (EGISTs) are rare, and may have similar histologic appearance to leiomyosarcomas. Thus, these tumors are often misdiagnosed when occurring in gynecologic organs. We present the fourth case of EGIST occurring in the rectovaginal septum and a review of the literature. A 56-year-old woman presented with a rectovaginal mass that was initially diagnosed as leiomyosarcoma and was treated with resection and adjuvant radiation. She presented with recurrence 4 years later and underwent a second resection. After a 5-year disease-free interval, she experienced a second recurrence and after resection was diagnosed with recurrent EGIST. EGISTs are rare but should be considered in the differential diagnosis of spindle-cell neoplasms located in or near the gynecologic tract.
authors.affiliation: Division of Gynecologic Oncology, The Ohio State University College of Medicine, Columbus, OH, USA.
authors.forename: Isela
authors.initials: I
authors.lastname: Molina
authors.forename: Leigh G
authors.initials: LG
authors.lastname: Seamon
authors.forename: Larry J
authors.initials: LJ
authors.lastname: Copeland
authors.forename: Adrian
authors.initials: A
authors.lastname: Suarez
mesh_terms: D003937:Diagnosis, Differential; D003951:Diagnostic Errors; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000175:diagnosis* / Q000628:therapy; D005833:Genital Neoplasms, Female / Q000175:diagnosis* / Q000628:therapy; D013509:Gynecologic Surgical Procedures; D006801:Humans; D007150:Immunohistochemistry; D007890:Leiomyosarcoma / Q000473:pathology* / Q000628:therapy; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000628:therapy; D011878:Radiotherapy