title: Hepatic Sinusoidal Obstruction Syndrome in a child after chemotherapy for medulloblastoma.
abstract: Hepatic Sinusoidal Obstruction Syndrome (HSOS), the new name given to veno-occlusive disease (VOD) of the liver, is a well-known complication of high-dose chemotherapy employed with hematopoietic stem cell transplantation, but it has rarely been observed in children who receive conventional chemotherapy. HSOS following standard chemotherapy has been reported in patients receiving vincristine, actinomycin D, and cyclophosphamide for the treatment of Wilms tumor and more rarely rhabdomyosarcoma. We report a 14-year-old boy with high risk medulloblastoma treated with craniospinal radiation followed by chemotherapy, who experienced severe HSOS after only one course of chemotherapy including carboplatin, vincristine, and cyclophosphamide. To our knowledge, this is the second report of HSOS after standard dose chemotherapy for brain tumor in childhood.
authors.affiliation: Division of Pediatric Hematology/Oncology, Tawam Hospital, Johns Hopkins Medicine, Al-Ain, United Arab Emirates. kishaqi@hotmail.com
authors.forename: M Kashif
authors.initials: MK
authors.lastname: Ishaqi
authors.forename: A
authors.initials: A
authors.lastname: Jamil
authors.forename: M
authors.initials: M
authors.lastname: Khanani
authors.forename: M
authors.initials: M
authors.lastname: Baroudi
authors.forename: Omar
authors.initials: O
authors.lastname: Trad
authors.forename: M
authors.initials: M
authors.lastname: El-Hayek
authors.forename: Eric
authors.initials: E
authors.lastname: Bouffet
mesh_terms: D000293:Adolescent; D000972:Antineoplastic Agents, Phytogenic / Q000009:adverse effects* / Q000627:therapeutic use; D002528:Cerebellar Neoplasms / Q000188:drug therapy; D003131:Combined Modality Therapy / Q000009:adverse effects*; D006504:Hepatic Veno-Occlusive Disease / Q000139:chemically induced*; D006801:Humans; D008297:Male; D008527:Medulloblastoma / Q000188:drug therapy; D014750:Vincristine / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D014750:Vincristine
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