Solitary cutaneous nodule of blastic plasmacytoid dendritic cell neoplasm progressing to overt leukemia cutis after chemotherapy: immunohistology and FISH analysis confirmed the diagnosis.
Blastic plasmacytoid dendritic cell (BPDC) neoplasm, formerly called blastic natural killer cell lymphoma or CD4+/CD56+ hematodermic neoplasm, is a rare tumor entity, now regarded to be derived from the plasmacytoid dendritic cell (PDC) lineage. Because over 90% of patients present with skin lesions usually early in their disease, dermatologists have to be familiar with the specific diagnostic features and the clinical course of this devastating disease. We present a woman with a long standing solitary skin tumor of BPDC neoplasm, who experienced a deleterious clinical course, which is typical for this disease. Phenotypic and karyotypic characteristics distinguishing this tumor from myelomonocytic leukemia with skin involvement are presented.
Kaune
Kjell Matthias
KM
Departments of Dermatology and Venereology, Georg August University Göttingen, Göttingen, Germany. kkaune@gwdg.de
Baumgart
Mario
M
Bertsch
Hans Peter
HP
Mitteldorf
Christina
C
Müller-Hermelink
Hans Konrad
HK
Haase
Detlef
D
Ghadimi
B Michael
BM
Schön
Michael Peter
MP
Neumann
Christine
C
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000150:complications; D014408:Biomarkers, Tumor / Q000032:analysis; D003713:Dendritic Cells / Q000473:pathology*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D018450:Disease Progression; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D007938:Leukemia / Q000235:genetics / Q000473:pathology*; D008223:Lymphoma / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*; D016609:Neoplasms, Second Primary / Q000473:pathology*; D012878:Skin Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*
D014408:Biomarkers, Tumor