[Distribution of aconitum alkaloids in the corpse died of acute aconite intoxication].
OBJECTIVE
To investigate the distribution of aconite alkaloids in biological fluids and tissues in the corpse died of acute aconite intoxication and to provide information for sample selection and result evaluation in forensic identification.


METHODS
The content of aconite alkaloids in biological fluids and tissues were determined by liquid chromatography-tandem mass spectrometry.


RESULTS
The content of aconite displayed in decending order of urine, bile, gastric content, heart blood, pancreas, heart, intestine, liver, kidney, stomach, lung, gallbladder and spleen, with no aconite detected in the brain.


CONCLUSIONS
It was indicated that urine, bile and blood are the best specimens for the determination of aconite in body of the acute aconite intoxication.
Liu
Wei
W
Department of Forensic Medicine, Shanghai Medical College, Fudan University, Shanghai 200032, China. liuwei0806@yahoo.com.cn
Shen
Min
M
Qin
Zhi-Qiang
ZQ
D000157:Aconitine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000652:urine; D031841:Aconitum / Q000737:chemistry / Q000506:poisoning*; D000208:Acute Disease; D001646:Bile / Q000737:chemistry*; D002853:Chromatography, Liquid / Q000379:methods; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000506:poisoning*; D005554:Forensic Medicine; D008401:Gas Chromatography-Mass Spectrometry; D005753:Gastric Mucosa / Q000378:metabolism*; D006801:Humans; D008099:Liver / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D014018:Tissue Distribution
D004365:Drugs, Chinese Herbal; C058309:hypaconitine; D000157:Aconitine