Solid-pseudopapillary neoplasm of the pancreas with massive central calcification in an old man.
Solid-pseudopapillary neoplasm (SPN) is a rare pancreatic tumor primarily affecting women in their twenties. It is characterized by a well-demarcated or encapsulated mass, indolent behavior and favorable prognosis. Capsular or punctate calcification is occasionally observed. Reported herein is a case of SPN of the pancreas with massive calcification in a 76-year-old Japanese man. Macroscopically, the pancreatic tumor appeared to be a simple calcified nodule, but histological examination revealed that it was an epithelioid tumor with massive calcification. The tumor cells, forming nests and cords, had eosinophilic cytoplasm and small eccentric nuclei. They were immunohistochemically positive for vimentin, CD56 and neuron-specific enolase. Nuclear accumulation of beta-catenin protein and a point mutation of the beta-catenin gene by genomic DNA sequencing confirmed that the tumor was SPN. This is a very rare case of pancreatic SPN with massive calcification in an old man.
Matsuda
Ikuo
I
Department of Surgical Pathology, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan.
Hao
Hiroyuki
H
Zozumi
Masataka
M
Koishi
Kenji
K
Matsumoto
Tomohiro
T
Kaibe
Nobuaki
N
Fujiwara
Yoshinori
Y
Sasako
Mitsuru
M
Hirota
Seiichi
S
D000230:Adenocarcinoma / Q000473:pathology; D000368:Aged; D001483:Base Sequence; D002114:Calcinosis / Q000473:pathology*; D002291:Carcinoma, Papillary / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D010190:Pancreatic Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D017354:Point Mutation; D013274:Stomach Neoplasms / Q000473:pathology; D051176:beta Catenin / Q000235:genetics
D051176:beta Catenin