Chapter 10: Conduit luminal additives for peripheral nerve repair.
The use of nerve conduits as an alternative for nerve grafting has a long experimental and clinical history. Luminal additives, factors introduced into these nerve conduits, were later developed to enhance the nerve regeneration through conduits. This chapter generalizes the types of additives used, and the reported performance of luminal additives in conduits to present a preference list for the most effective additives to use over specific distances of nerve defect.
Yan
Hede
H
Division of Plastic Surgery, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Zhang
Feng
F
Chen
Michael B
MB
Lineaweaver
William C
WC
D000818:Animals; D001842:Bone and Bones / Q000378:metabolism; D020934:Ciliary Neurotrophic Factor / Q000627:therapeutic use; D003094:Collagen / Q000627:therapeutic use; D005337:Fibrin / Q000627:therapeutic use; D005346:Fibroblast Growth Factors / Q000627:therapeutic use; D005347:Fibroblasts / Q000378:metabolism; D051100:Glial Cell Line-Derived Neurotrophic Factor / Q000627:therapeutic use; D007797:Laminin / Q000627:therapeutic use; D020932:Nerve Growth Factor / Q000627:therapeutic use; D009416:Nerve Regeneration / Q000187:drug effects*; D020890:Neuregulin-1 / Q000627:therapeutic use; D019635:Neurosurgical Procedures / Q000379:methods; D010525:Peripheral Nerves / Q000187:drug effects* / Q000601:surgery*; D012583:Schwann Cells / Q000378:metabolism; D017154:Stromal Cells / Q000378:metabolism; D054457:Tissue Scaffolds; D042461:Vascular Endothelial Growth Factor A / Q000627:therapeutic use
D020934:Ciliary Neurotrophic Factor; D051100:Glial Cell Line-Derived Neurotrophic Factor; D007797:Laminin; D020890:Neuregulin-1; D042461:Vascular Endothelial Growth Factor A; D005346:Fibroblast Growth Factors; D005337:Fibrin; D003094:Collagen; D020932:Nerve Growth Factor