Diversity-oriented synthesis of Kröhnke pyridines.
An efficient reagent-controlled approach for the regiospecific synthesis of new 2,2'-bipyridine derivatives in high-temperature water via microwave-assisted multicomponent reactions of aldehydes, 3-aryl-3-oxopropanenitrile, 2-acetylpyridine, and ammonium acetate is reported. Furthermore, aromatic aldehydes reacted with 1,2-diphenylethanone, resulting in structurally complex penta-arylpyridines. This chemistry provides an efficient and promising synthetic strategy to diversity-oriented construct poly arylpyridine skeleton.
Jiang
Bo
B
School of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou, 221116, PR China.
Hao
Wen-Juan
WJ
Wang
Xiang
X
Shi
Feng
F
Tu
Shu-Jiang
SJ
D000447:Aldehydes / Q000737:chemistry*; D006358:Hot Temperature; D008958:Models, Molecular; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry
D000447:Aldehydes; D011725:Pyridines