title: Activation of pregnane X receptor (PXR) and constitutive androstane receptor (CAR) by herbal medicines.
abstract: Pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are transcription factors that control the expression of a broad array of genes involved not only in transcellular transport and biotransformation of many drugs, other xenochemicals, and endogenous substances, such as bile acid, bilirubin, and certain vitamins, but also in various physiological/pathophysiological processes such as lipid metabolism, glucose homeostasis, and inflammation. Ligands of PXR and CAR are chemicals of diverse structures, including naturally occurring compounds present in herbal medicines. The overall aim of this article is to provide an overview of our current understanding of the role of herbal medicines as modulators of PXR and CAR.
authors.affiliation: Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, BC, Canada. tchang@interchange.ubc.ca
authors.forename: Thomas K H
authors.initials: TK
authors.lastname: Chang
mesh_terms: D000818:Animals; D000090702:Constitutive Androstane Receptor; D029001:Herbal Medicine; D006801:Humans; D010944:Plants / Q000145:classification; D000077297:Pregnane X Receptor; D051381:Rats; D018160:Receptors, Cytoplasmic and Nuclear / Q000819:agonists*; D011987:Receptors, Steroid / Q000819:agonists*
chemical_list: D000090702:Constitutive Androstane Receptor; D000077297:Pregnane X Receptor; D018160:Receptors, Cytoplasmic and Nuclear; D011987:Receptors, Steroid
references.citation: Mol Cell Biol. 1999 Sep;19(9):6318-22
references.pmid: 10454578
references.citation: Pharmacopsychiatry. 1998 Jun;31 Suppl 1:16-21
references.pmid: 9684943
references.citation: Food Chem Toxicol. 1994 Nov;32(11):1007-14
references.pmid: 7959454
references.citation: Indian J Med Res. 1988 Apr;87:327-35
references.pmid: 3049326
references.citation: J Pharmacol Exp Ther. 2004 Aug;310(2):528-35
references.pmid: 15075359
references.citation: Biochemistry. 2003 Feb 18;42(6):1430-8
references.pmid: 12578355
references.citation: Mol Pharmacol. 2004 Sep;66(3):413-9
references.pmid: 15322232
references.citation: J Clin Invest. 2008 Sep;118(9):3228-39
references.pmid: 18677425
references.citation: J Endocrinol. 2000 Sep;166(3):R11-6
references.pmid: 10974665
references.citation: Mol Pharmacol. 2002 Sep;62(3):439-45
references.pmid: 12181418
references.citation: Drug Metab Rev. 2006;38(1-2):75-87
references.pmid: 16684649
references.citation: Nature. 2000 Oct 19;407(6806):920-3
references.pmid: 11057673
references.citation: Drug Metab Dispos. 2007 Jun;35(6):995-1000
references.pmid: 17353348
references.citation: J Ethnopharmacol. 2008 Mar 28;116(3):383-96
references.pmid: 18308492
references.citation: Med Res Rev. 2007 Jan;27(1):133-48
references.pmid: 16888751
references.citation: Annu Rev Nutr. 2003;23:303-13
references.pmid: 12626688
references.citation: Xenobiotica. 2006 Oct-Nov;36(10-11):1152-63
references.pmid: 17118922
references.citation: Pharmacopsychiatry. 1997 Sep;30 Suppl 2:102-7
references.pmid: 9342769
references.citation: Annu Rev Pharmacol Toxicol. 2008;48:1-32
references.pmid: 17608617
references.citation: Mol Pharmacol. 2002 Sep;62(3):638-46
references.pmid: 12181440
references.citation: Chem Biol Interact. 2009 Jan 15;177(1):58-64
references.pmid: 18805405
references.citation: J Clin Invest. 1998 Sep 1;102(5):1016-23
references.pmid: 9727070
references.citation: Genes Dev. 1998 Oct 15;12(20):3195-205
references.pmid: 9784494
references.citation: Drug Metab Dispos. 2007 Feb;35(2):194-200
references.pmid: 17093002
references.citation: J Biol Chem. 2007 Dec 14;282(50):36766-76
references.pmid: 17962186
references.citation: J Nutr. 2006 Mar;136(3 Suppl):716S-725S
references.pmid: 16484550
references.citation: Int J Cardiol. 2007 Sep 14;121(1):9-22
references.pmid: 17363091
references.citation: Drug Metab Rev. 2006;38(1-2):51-73
references.pmid: 16684648
references.citation: Phytomedicine. 2006 Jan;13(1-2):119-31
references.pmid: 16360942
references.citation: J Pharm Pharmacol. 2006 Apr;58(4):521-7
references.pmid: 16597370
references.citation: J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Dec 5;812(1-2):203-14
references.pmid: 15556499
references.citation: J Biomol Screen. 2004 Sep;9(6):533-40
references.pmid: 15452340
references.citation: Drug Metab Dispos. 1992 Mar-Apr;20(2):142-7
references.pmid: 1352202
references.citation: J Biochem Mol Toxicol. 2005;19(1):1-11
references.pmid: 15736155
references.citation: Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):7500-2
references.pmid: 10852961
references.citation: Pharmacogenomics J. 2002;2(2):117-26
references.pmid: 12049174
references.citation: J Pharmacol Exp Ther. 2007 Jul;322(1):391-8
references.pmid: 17442842
references.citation: Eur J Pharmacol. 2005 Apr 4;512(1):9-13
references.pmid: 15814084
references.citation: J Pharmacol Exp Ther. 2006 Mar;316(3):1369-77
references.pmid: 16267138
references.citation: J Biol Chem. 2004 Jul 9;279(28):29295-301
references.pmid: 15123723
references.citation: Mol Pharm. 2008 Jan-Feb;5(1):35-41
references.pmid: 18159929
references.citation: Mol Cell Biol. 1994 Mar;14(3):1544-52
references.pmid: 8114692
references.citation: Curr Drug Metab. 2008 Dec;9(10):1027-37
references.pmid: 19075619
references.citation: Mol Pharmacol. 2009 Feb;75(2):363-73
references.pmid: 18978041
references.citation: Curr Drug Metab. 2008 Sep;9(7):614-21
references.pmid: 18781913
references.citation: Nature. 2000 Jul 27;406(6794):435-9
references.pmid: 10935643
references.citation: Mol Endocrinol. 2005 Sep;19(9):2258-72
references.pmid: 15905360
references.citation: J Psychopharmacol. 2005 Jul;19(4):414-21
references.pmid: 15982998
references.citation: Expert Opin Drug Metab Toxicol. 2006 Dec;2(6):847-57
references.pmid: 17125405
references.citation: Biochem Pharmacol. 2002 Sep;64(5-6):913-7
references.pmid: 12213586
references.citation: Clin Pharmacol Ther. 1979 May;25(5 Pt 1):591-7
references.pmid: 35298
references.citation: Drug Metab Dispos. 2008 Nov;36(11):2270-6
references.pmid: 18725505
references.citation: J Clin Endocrinol Metab. 2003 Sep;88(9):4446-54
references.pmid: 12970323
references.citation: Planta Med. 1997 Dec;63(6):548-9
references.pmid: 9434608
references.citation: J Pharmacol Exp Ther. 2005 Feb;312(2):849-56
references.pmid: 15459237
references.citation: Drug Metab Dispos. 2008 Aug;36(8):1538-45
references.pmid: 18474680
references.citation: Planta Med. 1985 Dec;51(6):473-7
references.pmid: 17345261
references.citation: Curr Drug Metab. 2006 May;7(4):375-88
references.pmid: 16724927
references.citation: J Pharm Sci. 1988 Dec;77(12):1003-6
references.pmid: 3244102
references.citation: Mol Endocrinol. 2003 Jul;17(7):1268-82
references.pmid: 12663745
references.citation: Environ Mol Mutagen. 2009 Apr;50(3):247-65
references.pmid: 19253339
references.citation: J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2008 Jan-Mar;26(1):89-112
references.pmid: 18322868
references.citation: Cell Mol Neurobiol. 2003 Jun;23(3):305-14
references.pmid: 12825829
references.citation: Pharmacol Rev. 2006 Dec;58(4):685-704
references.pmid: 17132848
references.citation: Basic Clin Pharmacol Toxicol. 2008 Jun;102(6):515-26
references.pmid: 18331392
references.citation: AIDS. 2005 Jan 3;19(1):95-7
references.pmid: 15627040
references.citation: J Altern Complement Med. 2005 Apr;11(2):245-56
references.pmid: 15865490
references.citation: Eur J Pharmacol. 2006 Sep 1;545(1):51-64
references.pmid: 16904103
references.citation: Drug Metab Dispos. 2004 Nov;32(11):1317-24
references.pmid: 15282211
references.citation: Drug Metab Dispos. 2005 Jan;33(1):38-48
references.pmid: 15466163
references.citation: Arch Biochem Biophys. 1999 Aug 1;368(1):14-22
references.pmid: 10415106
references.citation: J Pharmacol Exp Ther. 2007 Mar;320(3):1153-62
references.pmid: 17135343
references.citation: Drug Metab Dispos. 2003 Jan;31(1):7-10
references.pmid: 12485946
references.citation: Am J Chin Med. 2007;35(6):995-1009
references.pmid: 18186586
references.citation: Drug Metab Rev. 2006;38(3):515-97
references.pmid: 16877263
references.citation: J Pharmacol Exp Ther. 2006 Jun;317(3):1200-9
references.pmid: 16513849
references.citation: Drug Metab Dispos. 2009 Jun;37(6):1259-68
references.pmid: 19307295
references.citation: Dev Pharmacol Ther. 1991;16(1):59-64
references.pmid: 1879254
references.citation: Nat Rev Drug Discov. 2005 Mar;4(3):206-20
references.pmid: 15729362
references.citation: J Ethnopharmacol. 2008 Dec 8;120(3):419-26
references.pmid: 18930799
references.citation: Pharm Res. 2009 Apr;26(4):872-82
references.pmid: 19034627
references.citation: Mol Pharmacol. 2001 Feb;59(2):278-84
references.pmid: 11160864
references.citation: J Ethnopharmacol. 2008 Jul 23;118(2):183-212
references.pmid: 18515024
references.citation: Steroids. 2007 Mar;72(3):231-46
references.pmid: 17284330
references.citation: J Chromatogr A. 2009 Mar 13;1216(11):2002-32
references.pmid: 19195661
references.citation: Clin Cancer Res. 1999 Aug;5(8):2103-7
references.pmid: 10473093
references.citation: J Biol Chem. 2003 May 9;278(19):17277-83
references.pmid: 12611900
references.citation: J Pharm Biomed Anal. 2007 Sep 21;45(1):30-37
references.pmid: 17629436
references.citation: Mol Pharmacol. 2008 Dec;74(6):1512-20
references.pmid: 18768384
references.citation: Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12208-13
references.pmid: 9770465
references.citation: J Clin Invest. 2004 Jan;113(1):137-43
references.pmid: 14702117
references.citation: Am J Chin Med. 2004;32(2):221-34
references.pmid: 15315260
references.citation: Jpn J Pharmacol. 2002 Dec;90(4):345-51
references.pmid: 12501011
references.citation: Drug Metab Dispos. 2003 May;31(5):533-9
references.pmid: 12695340
references.citation: Mol Endocrinol. 2002 Jul;16(7):1590-7
references.pmid: 12089353
references.citation: Cell. 1998 Jan 9;92(1):73-82
references.pmid: 9489701
references.citation: J Agric Food Chem. 2008 Jul 9;56(13):5366-73
references.pmid: 18540626
references.citation: Mol Endocrinol. 2000 Jan;14(1):27-39
references.pmid: 10628745
references.citation: J Pharmacol Exp Ther. 2005 Jul;314(1):120-7
references.pmid: 15833898