title: Factors predictive of use and of benefit from continuous glucose monitoring in type 1 diabetes.
abstract: OBJECTIVE
  To evaluate factors associated with successful use of continuous glucose monitoring (CGM) among participants with intensively treated type 1 diabetes in the Juvenile Diabetes Research Foundation Continuous Glucose Monitoring Randomized Clinical Trial.
  
  
  METHODS
  The 232 participants randomly assigned to the CGM group (165 with baseline A1C >or=7.0% and 67 with A1C <7.0%) were asked to use CGM on a daily basis. The associations of baseline factors and early CGM use with CGM use >or=6 days/week in the 6th month and with change in A1C from baseline to 6 months were evaluated in regression models.
  
  
  RESULTS
  The only baseline factors found to be associated with greater CGM use in month 6 were age >or=25 years (P < 0.001) and more frequent self-reported prestudy blood glucose meter measurements per day (P < 0.001). CGM use and the percentage of CGM glucose values between 71 and 180 mg/dl during the 1st month were predictive of CGM use in month 6 (P < 0.001 and P = 0.002, respectively). More frequent CGM use was associated with a greater reduction in A1C from baseline to 6 months (P < 0.001), a finding present in all age-groups.
  
  
  CONCLUSIONS
  After 6 months, near-daily CGM use is more frequent in intensively treated adults with type 1 diabetes than in children and adolescents, although in all age-groups near-daily CGM use is associated with a similar reduction in A1C. Frequency of blood glucose meter monitoring and initial CGM use may help predict the likelihood of long-term CGM benefit in intensively treated patients with type 1 diabetes of all ages.
authors.affiliation: jdrfapp@jaeb.org
authors.forename: Roy W
authors.initials: RW
authors.lastname: Beck
authors.forename: Bruce
authors.initials: B
authors.lastname: Buckingham
authors.forename: Kellee
authors.initials: K
authors.lastname: Miller
authors.forename: Howard
authors.initials: H
authors.lastname: Wolpert
authors.forename: Dongyuan
authors.initials: D
authors.lastname: Xing
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: Block
authors.forename: H Peter
authors.initials: HP
authors.lastname: Chase
authors.forename: Irl
authors.initials: I
authors.lastname: Hirsch
authors.forename: Craig
authors.initials: C
authors.lastname: Kollman
authors.forename: Lori
authors.initials: L
authors.lastname: Laffel
authors.forename: Jean M
authors.initials: JM
authors.lastname: Lawrence
authors.forename: Kerry
authors.initials: K
authors.lastname: Milaszewski
authors.forename: Katrina J
authors.initials: KJ
authors.lastname: Ruedy
authors.forename: William V
authors.initials: WV
authors.lastname: Tamborlane
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis*; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000188:drug therapy; D005500:Follow-Up Studies; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007328:Insulin / Q000627:therapeutic use; D007332:Insulin Infusion Systems; D008875:Middle Aged; D018670:Monitoring, Ambulatory / Q000379:methods*; D018579:Patient Selection
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D007328:Insulin
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