title: A millisecond micromixer via single-bubble-based acoustic streaming.
abstract: We present ultra-fast homogeneous mixing inside a microfluidic channel via single-bubble-based acoustic streaming. The device operates by trapping an air bubble within a "horse-shoe" structure located between two laminar flows inside a microchannel. Acoustic waves excite the trapped air bubble at its resonance frequency, resulting in acoustic streaming, which disrupts the laminar flows and triggers the two fluids to mix. Due to this technique's simple design, excellent mixing performance, and fast mixing speed (a few milliseconds), our single-bubble-based acoustic micromixer may prove useful for many biochemical studies and applications.
authors.affiliation: Department of Engineering Science and Mechanics, The Pennsylvania State University, University Park, PA 16802, USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Ahmed
authors.forename: Xiaole
authors.initials: X
authors.lastname: Mao
authors.forename: Jinjie
authors.initials: J
authors.lastname: Shi
authors.forename: Bala Krishna
authors.initials: BK
authors.lastname: Juluri
authors.forename: Tony Jun
authors.initials: TJ
authors.lastname: Huang
mesh_terms: D000161:Acoustic Stimulation; D000465:Algorithms; D004129:Dimethylpolysiloxanes / Q000737:chemistry; D004867:Equipment Design; D044085:Microfluidics / Q000295:instrumentation*; D010316:Particle Size; D013500:Surface Tension
chemical_list: D004129:Dimethylpolysiloxanes; C013830:baysilon