A division of labor: asymmetric roles for GPCR subunits in receptor dimers.
The functional architecture of dimeric or oligomeric GPCR signaling remains incompletely understood. Using a clever combination of receptor-G protein fusions and various receptor mutations, new research provides a glimpse into how oligomers might be arranged with respect to the G proteins they interact with.
Zylbergold
Peter
P
Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada.
Hébert
Terence E
TE
D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D008024:Ligands; D011485:Protein Binding; D055503:Protein Multimerization; D021122:Protein Subunits; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism* / Q000502:physiology*; D015398:Signal Transduction
D008024:Ligands; D021122:Protein Subunits; D043562:Receptors, G-Protein-Coupled
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