title: eNOS haplotypes affect the responsiveness to antihypertensive therapy in preeclampsia but not in gestational hypertension.
abstract: Variations of the endothelial nitric oxide synthase (eNOS) gene have been associated with hypertensive disorders of pregnancy. We examined whether eNOS polymorphisms affect the therapeutic responses of women with gestational hypertension (GH) or preeclampsia (PE). We studied 304 hypertensive pregnant women (152 GH and 152 PE), who were stratified according to clinical and laboratorial parameters of therapeutic responsiveness. We compared the frequencies of three eNOS genetic polymorphisms (T-786C, Glu298Asp and b/a intron 4) in responsive and nonresponsive PE and GH patients. We found no significant differences in genotype or allele distributions when responsive and nonresponsive groups were compared (both PE or GH; all P>0.05). However, the eNOS haplotype distribution differed in PE (but not in GH)-responsive and -nonresponsive groups (P=0.0003). The 'C-Glu-a' and 'T-Asp-a' hapotypes were associated with responsiveness and nonresponsiveness to therapy, respectively (both P<0.001), thus suggesting that eNOS haplotypes affect the responsiveness to antihypertensive therapy in PE.
authors.affiliation: Santa Casa de Belo Horizonte, Av. Francisco Sales 1111, Belo Horizonte, MG, Brazil.
authors.forename: V C
authors.initials: VC
authors.lastname: Sandrim
authors.forename: A C T
authors.initials: AC
authors.lastname: Palei
authors.forename: M R
authors.initials: MR
authors.lastname: Luizon
authors.forename: T C
authors.initials: TC
authors.lastname: Izidoro-Toledo
authors.forename: R C
authors.initials: RC
authors.lastname: Cavalli
authors.forename: J E
authors.initials: JE
authors.lastname: Tanus-Santos
mesh_terms: D000328:Adult; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000188:drug therapy / Q000235:genetics*; D052250:Nitric Oxide Synthase Type III / Q000235:genetics*; D011110:Polymorphism, Genetic; D011225:Pre-Eclampsia / Q000188:drug therapy / Q000235:genetics*; D011247:Pregnancy
chemical_list: D000959:Antihypertensive Agents; C496314:NOS3 protein, human; D052250:Nitric Oxide Synthase Type III