title: Cerebral metabolism and sleep homeostasis: a comment on Vyazovskiy et al.
abstract: In this journal, Vyazovskiy et al. reported deoxyglucose data that they interpreted as supporting the Tononi and Cirelli hypothesis that cerebral metabolic rate (CMR) increases across waking. We summarize contradictory PET-deoxyglucose data that show CMR is the same in the morning and evening and that it decreases rather than increases after a night of sleep deprivation. We propose an alternative model of CMR-sleep homeostasis relations that points to novel experiments.
authors.forename: Irwin
authors.initials: I
authors.lastname: Feinberg
authors.forename: Ian G
authors.initials: IG
authors.lastname: Campbell
mesh_terms: D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging / Q000502:physiology*; D002940:Circadian Rhythm / Q000502:physiology; D003847:Deoxyglucose; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D051379:Mice; D008954:Models, Biological; D017440:Photoperiod; D049268:Positron-Emission Tomography; D012890:Sleep / Q000502:physiology*; D012892:Sleep Deprivation / Q000378:metabolism; D014851:Wakefulness / Q000502:physiology
chemical_list: D003847:Deoxyglucose
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