[Affects of transmission capability of nose mucociliary in radiotherapy].
OBJECTIVE
To investigate the effects of radioactive ray on transmission capability of nose mucociliary.


METHODS
Forty-six patients with NPC were selected and saccharin clearance time (SCT) for 7 phases were detected in both pre- and post-radiotherapy respectively.


RESULTS
Among 46 patients with NPC, the shortest SCT was 247 seconds and the longest 601 seconds in pre-radiotherapy phases; from 4th week of introradiotherapy to 18 months of postradiotherapy, the longest SCT was in 12 months after radiotherapy, which was 903 seconds. There were no significant differences in SCT before radiotherapy and 18 months after radiotherapy. There were significant differences in SCT of preradiotherapy and introdiotherapy, post radiotherapy, after radiotherapy 3 months, 6 months, 12 months after radiotherapy.


CONCLUSIONS
Radiotherapy is the important factors in influencing transmission capability of nose cavity and sinus mucociliary and hints that gender and nasal cavity side don't affect SCT. Detection of SCT in different stages of NPC patients can be helpful to protect nasal mucous membrane effectively, and to reduce incidence rate of RNS.
Zhang
Xuehui
X
Department of Otolaryngology Head and Neck Surgery, Second People's Hospital of Guangdong, Guangzhou, 510310, China. huangping64@163.com
Fu
Xiangjun
X
Huang
Jiannan
J
Xiao
Shupeng
S
Xiao
Ping
P
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009079:Mucociliary Clearance / Q000528:radiation effects*; D009297:Nasal Mucosa / Q000503:physiopathology*; D009303:Nasopharyngeal Neoplasms / Q000503:physiopathology* / Q000532:radiotherapy*; D012439:Saccharin / Q000378:metabolism; D055815:Young Adult
D012439:Saccharin