title: DWI lesion volume reduction following acute stroke treatment with transient partial aortic obstruction.
abstract: OBJECTIVE
  Diffusion-weighted imaging (DWI) identifies acute cerebral ischemia and DWI lesions are thought to indicate irreversibly damaged areas. However, new evidence suggests that DWI lesions may be reversible, especially with reperfusion. We present a patient who showed substantial reversal of her acute DWI lesion following partial aortic occlusion with Neuroflo™, a novel dual balloon catheter (Neuroflo™, CoAxia, MN).
  
  
  METHODS
  Case report/literature review.
  
  
  RESULTS
  A 48-year-old woman presented with left-sided weakness and demonstrated an acute DWI lesion in the right middle cerebral artery territory, with diffusion-perfusion mismatch. She was enrolled into an experimental study in which a dual balloon catheter was inflated in the lower aorta. The patient improved and her postprocedure magnetic resonance image showed a significant reduction in lesion volume on diffusion and perfusion-weighted imaging. At 1 month, a repeat computed tomography scan showed a small infarction in the right insula, lentiform nucleus, and frontal cortex. The patient had recovered with no significant disability at her 3-month follow-up.
  
  
  CONCLUSIONS
  Reperfusion can improve DWI lesions. Partial aortic obstruction with a novel dual balloon catheter may be useful to promote reperfusion.
authors.affiliation: Division of Neurology, Department of Medicine, University of Alberta, Edmonton, Canada.
authors.forename: Muhammad S
authors.initials: MS
authors.lastname: Hussain
authors.forename: Yusuf A
authors.initials: YA
authors.lastname: Bhagat
authors.forename: Songling
authors.initials: S
authors.lastname: Liu
authors.forename: James
authors.initials: J
authors.lastname: Scozzafava
authors.forename: Khurshid A
authors.initials: KA
authors.lastname: Khan
authors.forename: William P
authors.initials: WP
authors.lastname: Dillon
authors.forename: Ashfaq
authors.initials: A
authors.lastname: Shuaib
mesh_terms: D001011:Aorta / Q000601:surgery*; D021721:Balloon Occlusion / Q000379:methods*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D020521:Stroke / Q000473:pathology* / Q000601:surgery*; D016896:Treatment Outcome