Accuracy of teledermatology for pigmented neoplasms.
BACKGROUND
Accurate diagnosis and management of pigmented lesions is critical because of the morbidity and mortality associated with melanoma.


OBJECTIVE
We sought to compare accuracy of store-and-forward teledermatology for pigmented neoplasms with standard, in-person clinic dermatology.


METHODS
We conducted a repeated measures equivalence trial involving veterans with pigmented skin neoplasms. Each lesion was evaluated by a clinic dermatologist and a teledermatologist; both generated a primary diagnosis, up to two differential diagnoses, and a management plan. The primary outcome was aggregated diagnostic accuracy (match of any chosen diagnosis with histopathology). We also compared the severity of inappropriately managed lesions and, for teledermatology, evaluated the incremental change in accuracy when polarized light dermatoscopy or contact immersion dermatoscopy images were viewed.


RESULTS
We enrolled 542 patients with pigmented lesions, most were male (96%) and Caucasian (97%). The aggregated diagnostic accuracy rates for teledermatology (macro images, polarized light dermatoscopy, and contact immersion dermatoscopy) were not equivalent (95% confidence interval for difference within +/-10%) and were inferior (95% confidence interval lower bound <10%) to clinic dermatology. In general, the addition of dermatoscopic images did not significantly change teledermatology diagnostic accuracy rates. In contrast to diagnostic accuracy, rates of appropriate management plans for teledermatology were superior and/or equivalent to clinic dermatology (all image types: all lesions, and benign lesions). However, for the subgroup of malignant lesions (n = 124), the rate of appropriate management was significantly worse for teledermatology than for clinic dermatology (all image types). Up to 7 of 36 index melanomas would have been mismanaged via teledermatology.


CONCLUSIONS
Nondiverse study population and relatively small number of melanomas were limitations.


CONCLUSIONS
In general, the diagnostic accuracy of teledermatology was inferior whereas management was equivalent to clinic dermatology. However, for the important subgroup of malignant pigmented lesions, both diagnostic and management accuracy of teledermatology was generally inferior to clinic dermatology and up to 7 of 36 index melanomas would have been mismanaged via teledermatology. Teledermatology and teledermatoscopy should be used with caution for patients with suspected malignant pigmented lesions.
Warshaw
Erin M
EM
Minneapolis Veterans Affairs Medical Center, Center for Chronic Disease Outcomes Research, Minneapolis, Minnesota, USA. erin.warshaw@med.va.gov
Lederle
Frank A
FA
Grill
Joseph P
JP
Gravely
Amy A
AA
Bangerter
Ann K
AK
Fortier
Lawrence A
LA
Bohjanen
Kimberly A
KA
Chen
Karen
K
Lee
Peter K
PK
Rabinovitz
Harold S
HS
Johr
Robert H
RH
Kaye
Valda N
VN
Bowers
Sacharitha
S
Wenner
Rachel
R
Askari
Sharone K
SK
Kedrowski
Deborah A
DA
Nelson
David B
DB
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002280:Basal Cell Carcinoma / Q000175:diagnosis; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis; D003430:Cross-Sectional Studies; D003880:Dermatology / Q000379:methods / Q000592:standards*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000175:diagnosis*; D008875:Middle Aged; D009508:Nevus, Pigmented / Q000175:diagnosis*; D015203:Reproducibility of Results; D012871:Skin Diseases / Q000175:diagnosis; D012878:Skin Neoplasms / Q000175:diagnosis*; D017216:Telemedicine / Q000379:methods / Q000592:standards*; D055815:Young Adult