[A case of severe electrolytic disorder after adjuvant chemotherapy for esophageal cancer].
A 69-year-old female who had undergone esophagectomy for esophageal cancer was given adjuvant chemotherapy (5-FU 750 mg/body x 5 day, cisplatinum (CDDP) 100 mg/body x 1 day). An electrolytic disorder was found on day 2, and her consciousness became unclear on 5 day (respective Na, K and Cl values of 113, 2.2 and 67 mEq/L in blood). It took 59 days for infusion therapy to control electrolyte for loss in urine. As the b2-microglobulin level was high in urine and the ADH level in blood was normal, cisplatinum nephrotoxicity was thought to make this accident. Electrolytes should be checked carefully for disorder during chemotherapy.
Fukuhara
Kenichiro
K
Dept. of Surgery, Fujiidera City Hospital.
Omura
Toru
T
Katsuragi
Kunihiro
K
Osugi
Harushi
H
Lee
Shigeru
S
Kishida
Satoru
S
D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D017024:Chemotherapy, Adjuvant / Q000009:adverse effects*; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects; D004938:Esophageal Neoplasms / Q000188:drug therapy* / Q000601:surgery; D016629:Esophagectomy; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D014883:Water-Electrolyte Imbalance / Q000139:chemically induced*
D000964:Antimetabolites, Antineoplastic; D000970:Antineoplastic Agents; D002945:Cisplatin; D005472:Fluorouracil