title: Involvement of interleukin-21 in the epidermal hyperplasia of psoriasis.
abstract: T cells are crucial mediators of the skin damage in psoriasis. We here show that interleukin-21 (IL-21), a T cell-derived cytokine, is highly expressed in the skin of individuals with psoriasis, stimulates human keratinocytes to proliferate and causes epidermal hyperplasia when injected intradermally into mice. In the human psoriasis xenograft mouse model, blockade of IL-21 activity resolves inflammation and reduces keratinocyte proliferation. Blocking IL-21 may represent a new therapeutic strategy in psoriasis.
authors.affiliation: Gastroenterology, University Tor Vergata of Rome, Rome, Italy.
authors.forename: Roberta
authors.initials: R
authors.lastname: Caruso
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Botti
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Sarra
authors.forename: Maria
authors.initials: M
authors.lastname: Esposito
authors.forename: Carmine
authors.initials: C
authors.lastname: Stolfi
authors.forename: Laura
authors.initials: L
authors.lastname: Diluvio
authors.forename: Maria Laura
authors.initials: ML
authors.lastname: Giustizieri
authors.forename: Valentina
authors.initials: V
authors.lastname: Pacciani
authors.forename: Annamaria
authors.initials: A
authors.lastname: Mazzotta
authors.forename: Elena
authors.initials: E
authors.lastname: Campione
authors.forename: Thomas T
authors.initials: TT
authors.lastname: Macdonald
authors.forename: Sergio
authors.initials: S
authors.lastname: Chimenti
authors.forename: Francesco
authors.initials: F
authors.lastname: Pallone
authors.forename: Antonio
authors.initials: A
authors.lastname: Costanzo
authors.forename: Giovanni
authors.initials: G
authors.lastname: Monteleone
mesh_terms: D000818:Animals; D016022:Case-Control Studies; D049109:Cell Proliferation / Q000187:drug effects; D004195:Disease Models, Animal; D006801:Humans; D006965:Hyperplasia; D007378:Interleukins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000494:pharmacology / Q000502:physiology*; D015603:Keratinocytes / Q000187:drug effects / Q000276:immunology / Q000473:pathology / Q000637:transplantation; D051379:Mice; D011565:Psoriasis / Q000235:genetics / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D011994:Recombinant Proteins / Q000494:pharmacology; D013601:T-Lymphocytes / Q000276:immunology; D014183:Transplantation, Heterologous; D000098546:Interleukin-21
chemical_list: D007378:Interleukins; D012333:RNA, Messenger; D011994:Recombinant Proteins; D000098546:Interleukin-21
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