title: The junctions that don't fit the scheme: special symmetrical cell-cell junctions of their own kind.
abstract: Immunocytochemical, electron-, and immunoelectron-microscopical studies have revealed that, in addition to the four major "textbook categories" of cell-cell junctions (gap junctions, tight junctions, adherens junctions, and desmosomes), a broad range of other junctions exists, such as the tiny puncta adhaerentia minima, the taproot junctions (manubria adhaerentia), the plakophilin-2-containing adherens junctions of mesenchymal or mesenchymally derived cell types including malignantly transformed cells, the composite junctions (areae compositae) of the mature mammalian myocardium, the cortex adhaerens of the eye lens, the interdesmosomal "sandwich" or "stud" junctions in the subapical layers of stratified epithelia and the tumors derived therefrom, and the complexus adhaerentes of the endothelial and virgultar cells of the lymph node sinus. On the basis of their sizes and shapes, other morphological criteria, and their specific molecular ensembles, these junctions and the genes that encode them cannot be subsumed under one of the major categories mentioned above but represent special structures in their own right, appear to serve special functions, and can give rise to specific pathological disorders.
authors.affiliation: Helmholtz Group for Cell Biology, German Cancer Research Center, 69120, Heidelberg, Germany. w.franke@dkfz.de
authors.forename: Werner W
authors.initials: WW
authors.lastname: Franke
authors.forename: Steffen
authors.initials: S
authors.lastname: Rickelt
authors.forename: Mareike
authors.initials: M
authors.lastname: Barth
authors.forename: Sebastian
authors.initials: S
authors.lastname: Pieperhoff
mesh_terms: D000818:Animals; D015820:Cadherins / Q000378:metabolism; D006801:Humans; D007365:Intercellular Junctions / Q000145:classification / Q000378:metabolism / Q000648:ultrastructure*; D008565:Membrane Proteins / Q000378:metabolism*; D008856:Microscopy, Fluorescence; D016253:Microscopy, Immunoelectron; D051191:Plakophilins / Q000378:metabolism
chemical_list: D015820:Cadherins; D008565:Membrane Proteins; D051191:Plakophilins
references.citation: Histochem Cell Biol. 2008 May;129(5):539-50
references.pmid: 18386044
references.citation: Heart. 2006 Dec;92(12):1720-3
references.pmid: 16698823
references.citation: Cell Tissue Res. 2006 Apr;324(1):55-67
references.pmid: 16372193
references.citation: Heart Rhythm. 2006 Aug;3(8):939-44
references.pmid: 16876743
references.citation: Mol Biol Cell. 2004 Sep;15(9):4310-20
references.pmid: 15240821
references.citation: J Clin Invest. 2006 Jul;116(7):2012-21
references.pmid: 16823493
references.citation: Cell Tissue Res. 2007 Jun;328(3):499-514
references.pmid: 17372769
references.citation: Exp Cell Res. 2008 Dec 10;314(20):3669-83
references.pmid: 18845141
references.citation: Circ Res. 2006 Sep 15;99(6):646-55
references.pmid: 16917092
references.citation: Neth Heart J. 2007;15(10):348-53
references.pmid: 18167567
references.citation: Cell. 2000 Jan 21;100(2):209-19
references.pmid: 10660044
references.citation: Chin Med J (Engl). 2009 Feb 20;122(4):403-7
references.pmid: 19302745
references.citation: Cell. 1999 May 28;97(5):599-607
references.pmid: 10367889
references.citation: J Cell Biol. 1996 Nov;135(4):1009-25
references.pmid: 8922383
references.citation: Circulation. 2006 Apr 4;113(13):1650-8
references.pmid: 16567567
references.citation: Microvasc Res. 2001 Jan;61(1):40-8
references.pmid: 11162194
references.citation: Science. 2004 Feb 13;303(5660):1007-10
references.pmid: 14963329
references.citation: Eur J Cell Biol. 2007 Dec;86(11-12):645-55
references.pmid: 17291627
references.citation: Circulation. 2007 Apr 3;115(13):1710-20
references.pmid: 17372169
references.citation: Curr Opin Cardiol. 2006 Jan;21(1):55-63
references.pmid: 16355031
references.citation: J Am Coll Cardiol. 2003 Jul 16;42(2):319-27
references.pmid: 12875771
references.citation: Curr Opin Cell Biol. 2007 Oct;19(5):515-20
references.pmid: 17951043
references.citation: Proc Natl Acad Sci U S A. 2001 Jul 3;98(14):7795-800
references.pmid: 11416169
references.citation: Circulation. 2006 Jan 24;113(3):356-64
references.pmid: 16415378
references.citation: Int J Cancer. 2009 Nov 1;125(9):2036-48
references.pmid: 19551809
references.citation: J Cell Mol Med. 2009 Oct;13(10):4219-28
references.pmid: 18662195
references.citation: Eur J Cell Biol. 2007 Jul;86(7):377-91
references.pmid: 17532539
references.citation: Cell Tissue Res. 2008 Dec;334(3):381-99
references.pmid: 19005682
references.citation: Mol Cell Biol. 2002 Jul;22(13):4760-70
references.pmid: 12052883
references.citation: Eur J Cell Biol. 2004 Dec;83(11-12):655-65
references.pmid: 15679110
references.citation: Circulation. 2005 Aug 2;112(5):636-42
references.pmid: 16061754
references.citation: Dev Growth Differ. 1989 Jun;31(3):209-218
references.pmid: 37282144
references.citation: Heart. 2009 May;95(9):766-73
references.pmid: 19366719
references.citation: Am J Hum Genet. 2007 Nov;81(5):964-73
references.pmid: 17924338
references.citation: J Cell Sci. 2003 Dec 15;116(Pt 24):4985-95
references.pmid: 14625392
references.citation: Eur J Cell Biol. 1993 Aug;61(2):274-89
references.pmid: 8223718
references.citation: J Cell Biol. 2004 Oct 11;167(1):149-60
references.pmid: 15479741
references.citation: Am J Hum Genet. 2006 Nov;79(5):978-84
references.pmid: 17033975
references.citation: J Cell Sci. 2007 Jun 15;120(Pt 12):2126-36
references.pmid: 17535849
references.citation: Hum Mol Genet. 2000 Nov 1;9(18):2761-6
references.pmid: 11063735
references.citation: Circulation. 2006 Apr 4;113(13):1641-9
references.pmid: 16549640
references.citation: J Cell Sci. 2004 Jul 1;117(Pt 15):3129-40
references.pmid: 15190119
references.citation: J Cell Sci. 2009 Jan 1;122(Pt 1):21-4
references.pmid: 19092057
references.citation: Circ J. 2006 Jul;70(7):933-5
references.pmid: 16799251
references.citation: Eur J Cell Biol. 2006 Feb;85(2):69-82
references.pmid: 16406610
references.citation: J Cell Biol. 2002 Mar 18;156(6):1099-111
references.pmid: 11889141
references.citation: J Cell Sci. 1998 Oct;111 ( Pt 20):3045-57
references.pmid: 9739078
references.citation: Dev Biol. 2006 Jan 15;289(2):430-41
references.pmid: 16337936
references.citation: EMBO J. 1983;2(5):735-42
references.pmid: 6416832
references.citation: Cold Spring Harb Perspect Biol. 2009 Sep;1(3):a003061
references.pmid: 20066111
references.citation: Trends Cardiovasc Med. 2003 Jan;13(1):30-8
references.pmid: 12554098
references.citation: J Cell Sci. 1996 Aug;109 ( Pt 8):2141-9
references.pmid: 8856510
references.citation: Am J Cardiol. 2009 May 15;103(10):1439-44
references.pmid: 19427443
references.citation: Eur J Cell Biol. 2006 Jun;85(6):469-85
references.pmid: 16600422
references.citation: Nat Rev Microbiol. 2006 Jun;4(6):423-34
references.pmid: 16710323
references.citation: Int Rev Cytol. 2007;264:65-163
references.pmid: 17964922
references.citation: Differentiation. 1983;25(2):121-41
references.pmid: 6198231
references.citation: Cell Tissue Res. 2009 Jan;335(1):109-41
references.pmid: 19015886
references.citation: Int J Cardiol. 2008 May 7;126(1):92-100
references.pmid: 17521752
references.citation: BMC Med Genet. 2007 Oct 26;8:65
references.pmid: 17963498
references.citation: Nat Cell Biol. 2009 Mar;11(3):328-36
references.pmid: 19198598
references.citation: J Formos Med Assoc. 2008 Jul;107(7):548-58
references.pmid: 18632414
references.citation: Nat Clin Pract Cardiovasc Med. 2008 May;5(5):258-67
references.pmid: 18382419
references.citation: Eur J Cell Biol. 2002 Aug;81(8):419-35
references.pmid: 12234014
references.citation: Cell. 2007 Nov 30;131(5):966-79
references.pmid: 18045538
references.citation: Differentiation. 1994 Aug;57(2):97-117
references.pmid: 8070626
references.citation: Cell Tissue Res. 2009 Jul;337(1):63-77
references.pmid: 19475424
references.citation: Eur J Cell Biol. 2003 Aug;82(8):385-400
references.pmid: 14533737
references.citation: J Cardiovasc Electrophysiol. 2008 Nov;19(11):1212-4
references.pmid: 18554203
references.citation: Tissue Cell. 1985;17(5):605-48
references.pmid: 3904080
references.citation: Eur Heart J. 2007 Mar;28(5):581-8
references.pmid: 17105751
references.citation: Eur Heart J. 2006 Sep;27(18):2208-16
references.pmid: 16893920
references.citation: Eur J Immunol. 2008 Aug;38(8):2142-55
references.pmid: 18629939
references.citation: Am J Hum Genet. 2006 Jul;79(1):136-42
references.pmid: 16773573
references.citation: Am J Hum Genet. 2006 Dec;79(6):1081-8
references.pmid: 17186466
references.citation: Am J Cardiol. 1970 Feb;25(2):169-83
references.pmid: 5513797
references.citation: Nat Cell Biol. 2009 Mar;11(3):235-6
references.pmid: 19255567
references.citation: Histochem Cell Biol. 2008 Jul;130(1):21-54
references.pmid: 18386043
references.citation: Proc Natl Acad Sci U S A. 1995 Jun 20;92(13):6022-6
references.pmid: 7597073
references.citation: Heart Rhythm. 2008 Dec;5(12):1715-23
references.pmid: 19084810
references.citation: J Cardiovasc Electrophysiol. 2005 Aug;16(8):927-35
references.pmid: 16101641
references.citation: Microsc Res Tech. 1993 Nov 1;26(4):301-28
references.pmid: 8305722
references.citation: J Invest Dermatol. 1998 Jun;110(6):862-6
references.pmid: 9620290
references.citation: J Exp Med. 2007 Oct 1;204(10):2349-62
references.pmid: 17846148
references.citation: Eur J Cell Biol. 2008 Jul;87(7):399-411
references.pmid: 18261826
references.citation: Heart Rhythm. 2008 Dec;5(12):1724-5
references.pmid: 19084811
references.citation: Nat Cell Biol. 2008 Feb;10(2):211-9
references.pmid: 18193035
references.citation: N Engl J Med. 2009 Mar 12;360(11):1075-84
references.pmid: 19279339
references.citation: Nat Genet. 2004 Nov;36(11):1162-4
references.pmid: 15489853
references.citation: Circulation. 2006 Mar 7;113(9):1171-9
references.pmid: 16505173
references.citation: Am J Hum Genet. 2002 Nov;71(5):1200-6
references.pmid: 12373648
references.citation: Mol Biol Cell. 2006 May;17(5):2366-76
references.pmid: 16525026
references.citation: Clin Res Cardiol. 2009 Mar;98(3):141-58
references.pmid: 19205777
references.citation: Eur J Cell Biol. 2002 May;81(5):253-63
references.pmid: 12067061
references.citation: Development. 2001 Mar;128(6):929-41
references.pmid: 11222147
references.citation: Circ Res. 2007 Sep 28;101(7):703-11
references.pmid: 17673670