Effects of caffeic acid and cinnamic acid on glucose uptake in insulin-resistant mouse hepatocytes.
Tumor necrosis factor-alpha was used to induce insulin resistance of mouse liver FL83B cells. Two phenolic acids, caffeic acid and cinnamic acid, were then added separately to investigate their effects on glucose uptake of the insulin-resistant cells. The results suggest that these two phenolic acids may promote insulin receptor tyrosyl phosphorylation, up-regulate the expression of insulin signal associated proteins, including insulin receptor, phosphatidylinositol-3 kinase, glycogen synthase, and glucose transporter-2, increase the uptake of glucose, and alleviate insulin resistance in cells as a consequence.
Huang
Da-Wei
DW
Graduate Institute of Food Science and Technology, College of Bioresources and Agriculture, National Taiwan University, Taipei 106, Taiwan.
Shen
Szu-Chuan
SC
Wu
James Swi-Bea
JS
D000818:Animals; D002109:Caffeic Acids / Q000494:pharmacology*; D002460:Cell Line; D002934:Cinnamates / Q000494:pharmacology*; D005947:Glucose / Q000378:metabolism*; D022781:Hepatocytes / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism*; D007333:Insulin Resistance; D051379:Mice; D019869:Phosphatidylinositol 3-Kinases / Q000032:analysis; D010766:Phosphorylation / Q000187:drug effects; D011972:Receptor, Insulin / Q000032:analysis / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology; D014443:Tyrosine / Q000378:metabolism
D002109:Caffeic Acids; D002934:Cinnamates; D005947:Glucose; D019869:Phosphatidylinositol 3-Kinases; D011972:Receptor, Insulin; D014409:Tumor Necrosis Factor-alpha; D014443:Tyrosine; C029010:cinnamic acid; C040048:caffeic acid