title: Cancer: CINful centrosomes.
abstract: The regulation of centrosome number is lost in many tumors and the presence of extra centrosomes correlates with chromosomal instability. Recent work now reveals how extra centrosomes cause chromosome mis-segregation in tumor cells.
authors.affiliation: Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755, USA.
authors.forename: Samuel F
authors.initials: SF
authors.lastname: Bakhoum
authors.forename: Duane A
authors.initials: DA
authors.lastname: Compton
mesh_terms: D002455:Cell Division; D018385:Centrosome / Q000502:physiology*; D043171:Chromosomal Instability / Q000502:physiology*; D018386:Kinetochores / Q000502:physiology; D008870:Microtubules / Q000502:physiology; D008954:Models, Biological; D009369:Neoplasms / Q000503:physiopathology*
references.citation: Nature. 2005 Oct 13;437(7061):1043-7
references.pmid: 16222300
references.citation: Nat Cell Biol. 2009 Jan;11(1):27-35
references.pmid: 19060894
references.citation: Dev Cell. 2007 Aug;13(2):190-202
references.pmid: 17681131
references.citation: Nature. 2009 Jul 9;460(7252):278-82
references.pmid: 19506557
references.citation: Proc Natl Acad Sci U S A. 2004 Jun 8;101(23):8699-704
references.pmid: 15159543
references.citation: Nat Rev Cancer. 2002 Nov;2(11):815-25
references.pmid: 12415252
references.citation: Nat Rev Mol Cell Biol. 2007 Jun;8(6):451-63
references.pmid: 17505520
references.citation: J Cell Sci. 2002 Feb 1;115(Pt 3):507-15
references.pmid: 11861758
references.citation: Cell. 2008 Jun 13;133(6):1032-42
references.pmid: 18555779
references.citation: Science. 2008 Oct 31;322(5902):703-9
references.pmid: 18974345
references.citation: Genes Dev. 2008 Aug 15;22(16):2189-203
references.pmid: 18662975
references.citation: Genes Chromosomes Cancer. 2000 Feb;27(2):183-90
references.pmid: 10612807
references.citation: Cancer Cell. 2008 Aug 12;14(2):111-22
references.pmid: 18656424
references.citation: Oncogene. 2002 Sep 9;21(40):6146-53
references.pmid: 12214243
references.citation: Cancer Res. 2001 Mar 1;61(5):2212-9
references.pmid: 11280789
references.citation: J Cell Biol. 2001 Apr 30;153(3):517-27
references.pmid: 11331303
references.citation: Nature. 1998 Dec 17;396(6712):643-9
references.pmid: 9872311
references.citation: Science. 2005 Jan 7;307(5706):127-9
references.pmid: 15637283
references.citation: J Cell Sci. 2003 Oct 15;116(Pt 20):4213-25
references.pmid: 12953065
references.citation: J Cell Biol. 2008 Feb 25;180(4):665-72
references.pmid: 18283116