Measurement of donor kidney functional renal volume and glomerular filtration rate to predict allograft function during the post-transplantation period.
BACKGROUND
We measured donor kidney weight (D-KW), functional renal volume (D-FRV), and single-kidney glomerular filtration rate (D-SKGFR), and then evaluated the impact of the indices to recipient body weight (R-BW) on graft function.


METHODS
This study included 44 recipients of live donor transplants without delayed graft function or acute rejection within 2 years of transplantation.


RESULTS
There was a statistically significant difference in serum creatinine between recipients with a D-KW/R-BW ratio of <or=4.25, D-FRV/R-BW ratio of <or=5.14, or D-SKGFR/R-BW ratio of <or=1.06 and recipients with a D-KW/R-BW ratio of >4.25, D-FRV/R-BW ratio of >5.14, or D-SKGFR/R-BW ratio of >1.06, respectively. D-KW/R-BW, D-FRV/R-BW, and D-SKGFR/R-BW strongly correlated with serum creatinine at 1 year and 2 years post-transplantation. In multivariate analysis, D-FRV and donor age were statistically significant risk factors which influenced serum creatinine at 1 year and 2 years post-transplantation.


CONCLUSIONS
D-FRV/R-BW and donor age have significant impact on graft function. D-FRV/R-BW can be measured ahead of surgery. Therefore, measuring the D-FRV is useful to select a more optimal donor kidney among otherwise similar candidates during preoperative evaluation to improve posttransplant graft function.
Huh
Kyu Ha
KH
Department of Surgery, Yonsei University College of Medicine, Seoul, Korea.
Yun
Mijin
M
Kim
Tae Sung
TS
Cho
Arthur
A
Lee
Jong Doo
JD
Myoung
Sung Min
SM
Kim
Yu Seun
YS
Kim
Myoung Soo
MS
D000328:Adult; D005260:Female; D005919:Glomerular Filtration Rate; D006084:Graft Rejection / Q000175:diagnosis* / Q000209:etiology*; D006801:Humans; D007668:Kidney / Q000000981:diagnostic imaging*; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D011184:Postoperative Period; D011866:Radioisotope Renography / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D016896:Treatment Outcome; D055815:Young Adult