title: Expression of VEGF and VEGF receptors in childhood precursor B-cell acute lymphoblastic leukemia evaluated by immunohistochemistry.
abstract: Perturbation in the expression and signaling pathways of vascular endothelial growth factor (VEGF) has been linked to pathogenesis of hematologic malignancies. We investigated the expression and clinical importance of VEGF and two of its receptors, VEGFR-1 and VEGFR-2, in childhood precursor B-cell acute lymphoblastic leukemia (pre-B ALL) by using immunohistochemistry. These angiogenic proteins were expressed in the majority of leukemic bone marrow samples. Notably, pre-B ALL patients had significantly increased expression of VEGFR-1 compared with no expression in the nonmalignant group, indicating a link between VEGFR-1 protein expression and pre-B ALL. These novel findings suggest that VEGFR-1 may have clinical importance in childhood pre-B ALL.
authors.affiliation: Department of Laboratory Medicine, Clinical Research Center, Lund University, Sweden.
authors.forename: Eva
authors.initials: E
authors.lastname: Diffner
authors.forename: Fredrika
authors.initials: F
authors.lastname: Gauffin
authors.forename: Lola
authors.initials: L
authors.lastname: Anagnostaki
authors.forename: Ann
authors.initials: A
authors.lastname: Nordgren
authors.forename: Bertil
authors.initials: B
authors.lastname: Gustafsson
authors.forename: Birgitta
authors.initials: B
authors.lastname: Sander
authors.forename: Britt
authors.initials: B
authors.lastname: Gustafsson
authors.forename: Jenny Liao
authors.initials: JL
authors.lastname: Persson
mesh_terms: D000293:Adolescent; D001853:Bone Marrow / Q000378:metabolism / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D015973:Gene Expression Regulation, Leukemic; D006801:Humans; D007124:Immunoenzyme Techniques; D007223:Infant; D008297:Male; D009363:Neoplasm Proteins / Q000032:analysis* / Q000096:biosynthesis / Q000235:genetics; D009389:Neovascularization, Pathologic / Q000235:genetics; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics / Q000378:metabolism*; D011379:Prognosis; D042461:Vascular Endothelial Growth Factor A / Q000032:analysis* / Q000096:biosynthesis / Q000235:genetics; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000032:analysis* / Q000096:biosynthesis / Q000235:genetics; D040301:Vascular Endothelial Growth Factor Receptor-2 / Q000032:analysis* / Q000096:biosynthesis / Q000235:genetics
chemical_list: D009363:Neoplasm Proteins; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D040281:Vascular Endothelial Growth Factor Receptor-1; D040301:Vascular Endothelial Growth Factor Receptor-2