Processing umami and other tastes in mammalian taste buds.
Neuroscientists are now coming to appreciate that a significant degree of information processing occurs in the peripheral sensory organs of taste prior to signals propagating to the brain. Gustatory stimulation causes taste bud cells to secrete neurotransmitters that act on adjacent taste bud cells (paracrine transmitters) as well as on primary sensory afferent fibers (neurocrine transmitters). Paracrine transmission, representing cell-cell communication within the taste bud, has the potential to shape the final signal output that taste buds transmit to the brain. The following paragraphs summarize current thinking about how taste signals generally, and umami taste in particular, are processed in taste buds.
Roper
Stephen D
SD
Department of Physiology and Biophysics, and Program in Neuroscience, Miller School of Medicine, University of Miami, Miami, Florida 33136, USA. sroper@med.miami.edu
Chaudhari
Nirupa
N
D000818:Animals; D008954:Models, Biological; D009435:Synaptic Transmission; D013649:Taste; D013650:Taste Buds / Q000166:cytology / Q000502:physiology*
Eur J Neurosci. 2000 Sep;12(9):3163-71
10998100
Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6436-41
17389364
J Neurosci. 2000 Nov 1;20(21):7978-85
11050118
J Neurosci. 2006 Apr 12;26(15):3971-80
16611813
BMC Biol. 2006 Mar 30;4:7
16573824
Adv Anat Embryol Cell Biol. 1978;55(1):3-94
358774
J Neurosci. 1994 Jun;14(6):3791-804
8207488
J Comp Neurol. 2004 Jan 12;468(3):311-21
14681927
J Neurosci. 2003 Apr 1;23(7):2608-17
12684446
J Comp Neurol. 2001 Nov 5;440(1):97-108
11745610
J Physiol. 2008 Jun 15;586(12):2903-12
18420705
Chem Senses. 1996 Jun;21(3):353-65
8670715
Annu Rev Neurosci. 1989;12:329-53
2648951
J Neurosci. 2005 Jan 26;25(4):843-7
15673664
J Comp Neurol. 2007 Nov 20;505(3):302-13
17879273
Zh Evol Biokhim Fiziol. 1983 Jan-Feb;19(1):62-7
6601342
Am J Physiol Regul Integr Comp Physiol. 2004 Apr;286(4):R649-58
14715493
EMBO J. 2007 Feb 7;26(3):657-67
17235286
BMC Neurosci. 2008 Jan 02;9:1
18171468
J Neurosci. 2008 Dec 3;28(49):13088-93
19052199
J Neurosci. 2007 Oct 3;27(40):10840-8
17913917
Science. 2005 Dec 2;310(5753):1495-9
16322458
J Comp Neurol. 2006 Jul 1;497(1):1-12
16680780
J Neurophysiol. 1992 May;67(5):1316-24
1597715