Normalization of diabetic wound healing.
Impaired wound healing in diabetics is due to pathologic angiogenesis, which is a result of aberrant sphingosine-1-phosphate signaling. Pharmacologic modulation of sphingosine-1-phosphate-dependent signaling normalizes healing in diabetic wounds.
Francis-Goforth
Kellie N
KN
Department of General Surgery, University of California San Francisco-East Bay, Oakland, CA, USA.
Harken
Alden H
AH
Saba
Julie D
JD
D048909:Diabetes Complications / Q000209:etiology* / Q000503:physiopathology / Q000517:prevention & control*; D006801:Humans; D008246:Lysophospholipids / Q000502:physiology*; D012883:Skin Ulcer / Q000209:etiology* / Q000503:physiopathology / Q000517:prevention & control*; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000502:physiology; D014945:Wound Healing / Q000502:physiology*
D008246:Lysophospholipids; C060506:sphingosine 1-phosphate; D013110:Sphingosine
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