WNTs tune up the neuromuscular junction.
Although WNTs have been long thought of as regulators of cell fate, recent studies highlight their involvement in crucial aspects of synaptic development in the nervous system. Particularly compelling are recent studies of the neuromuscular junction in nematodes, insects, fish and mammals. These studies place WNTs as major determinants of synapse differentiation and neurotransmitter receptor clustering.
Korkut
Ceren
C
Department of Neurobiology, Aaron Lazare Biomedical Research Building, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.
Budnik
Vivian
V
D000818:Animals; D006801:Humans; D009469:Neuromuscular Junction / Q000737:chemistry / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D013569:Synapses / Q000737:chemistry / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology; D051153:Wnt Proteins / Q000737:chemistry / Q000502:physiology*
D051153:Wnt Proteins
Neuroscientist. 2002 Oct;8(5):497-511
12374432
Development. 2005 Jul;132(13):3079-92
15930100
J Cell Biol. 2004 Jan 19;164(2):243-53
14734535
J Neurosci. 2008 Oct 22;28(43):10875-84
18945895
Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2483-8
17284594
Growth Factors. 2005 Jun;23(2):111-6
16019432
Nat Cell Biol. 2001 Sep;3(9):802-8
11533659
Dev Neurobiol. 2008 Feb 1;68(2):152-65
17963254
Dev Cell. 2008 Nov;15(5):635-6
19000826
Neuron. 2008 Mar 13;57(5):705-18
18341991
Annu Rev Neurosci. 2008;31:339-58
18558859
Brain Res Brain Res Rev. 2000 Aug;33(1):1-12
10967351
Neuron. 2001 May;30(2):399-410
11395002
Nat Neurosci. 2008 Mar;11(3):262-8
18278041
Cell. 1996 May 17;85(4):501-12
8653786
Cell. 1996 May 17;85(4):513-23
8653787
Genetics. 2008 Dec;180(4):2057-71
18832361
Nat Cell Biol. 2005 May;7(5):463-73
15892196
Neuron. 2008 Oct 23;60(2):285-97
18957220
J Neurosci. 2004 Jul 28;24(30):6776-84
15282282
Mol Cell Neurosci. 2006 Oct;33(2):188-99
16949836
Nat Rev Neurosci. 2001 Nov;2(11):791-805
11715056
Cell. 2007 Aug 24;130(4):704-16
17719547
J Biol Chem. 2008 Aug 1;283(31):21668-75
18541538
J Cell Biol. 2000 Jul 10;150(1):205-12
10893268
Nat Neurosci. 2005 Jul;8(7):906-15
15965473
Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18812-7
19020093
Nat Neurosci. 2002 Feb;5(2):141-6
11753421
Curr Opin Cell Biol. 2005 Feb;17(1):47-54
15661518
J Biol Chem. 2003 Oct 3;278(40):38522-7
12885777
Nature. 1994 Dec 1;372(6505):461-4
7984239
Proc Natl Acad Sci U S A. 2006 May 16;103(20):7841-6
16682643
Dev Biol. 1997 Dec 1;192(1):31-44
9405095
Bioinform Biol Insights. 2008 Nov 03;2:369-81
19812789
Nature. 1993 Jan 28;361(6410):350-3
8426654
Annu Rev Neurosci. 1999;22:389-442
10202544
Neuron. 2009 Mar 12;61(5):721-33
19285469
Neuron. 2001 Jul 19;31(1):15-22
11498047
Nature. 2001 Apr 26;410(6832):1057-64
11323662
Neuron. 2002 Nov 14;36(4):635-48
12441053
Science. 2005 Nov 25;310(5752):1344-7
16311339
J Neurochem. 2006 Jun;97(6):1520-33
16805766
Trends Neurosci. 2007 Jun;30(6):268-75
17467065
Nat Neurosci. 2003 Oct;6(10):1017-8
14502292
J Mol Histol. 2008 Jun;39(3):329-37
18392598
Dev Cell. 2008 Nov;15(5):773-80
19000841
Nat Neurosci. 2008 Jan;11(1):19-27
18084289
Rev Endocr Metab Disord. 2006 Jun;7(1-2):41-9
16944325
Cell. 2006 Nov 3;127(3):591-606
17081980
Development. 2006 Dec;133(24):4993-5000
17119023
Commun Integr Biol. 2008;1(2):158-60
19704879
Neuron. 2002 Sep 12;35(6):1043-56
12354395
Cell. 2002 Nov 1;111(3):319-30
12419243
J Neurosci. 2007 Apr 11;27(15):3968-73
17428970
Neuron. 2005 May 19;46(4):581-94
15944127
Neuron. 2006 Jan 5;49(1):11-6
16387635
Mol Membr Biol. 2002 Jan-Mar;19(1):27-38
11989820
J Cell Sci. 1998 May;111 ( Pt 10):1351-61
9570753
Neuron. 2008 Nov 26;60(4):526-8
19038209
J Neurosci. 2003 May 1;23(9):3577-87
12736328
Curr Opin Neurobiol. 2006 Feb;16(1):74-82
16386415
Int Rev Neurobiol. 2006;75:267-85
17137932
J Neurosci. 2007 Jan 3;27(1):111-23
17202478
Cancer Cell. 2002 Oct;2(4):323-34
12398896
Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9924-9
11493710
J Biol Chem. 2003 Feb 21;278(8):6450-5
12473646
Cell. 2008 Oct 17;135(2):334-42
18848351
Mol Cell Neurosci. 2008 Jun;38(2):138-52
18407517
Hum Mol Genet. 2003 Apr 1;12(7):739-48
12651869
Neurochem Int. 2002 Nov;41(5):341-4
12176076
Dev Cell. 2009 Mar;16(3):325-7
19289078
Biosci Rep. 2005 Oct-Dec;25(5-6):309-27
16307379
Bioessays. 1994 Jun;16(6):395-404
8080429
Neuron. 2002 Aug 1;35(3):489-505
12165471
Nature. 2004 Sep 30;431(7008):578-82
15457263
Mol Cell Neurosci. 2006 Feb;31(2):251-62
16243537
Nat Neurosci. 2005 Jan;8(1):34-42
15608632
BMC Neurosci. 2005 Jun 28;6:44
15985179