Cycloartane triterpenes from dikamali, the gum resin of Gardenia gummifera and Gardenia lucida.
We report on the chemical investigation of dikamali gum, which is the resin of Gardenia gummifera and G. lucida (Rubiaceae). Six new cycloartane triterpenes, dikamaliartanes A-F (1-6, resp.), together with a known flavonoid (7), were isolated and identified by NMR spectroscopy. All six cycloartanes are characterized by an open A-ring with a free COOH group at C(3). In four of them, the C-atoms C(23)-C(27) form a 4-methylfuran-2-yl moiety. Bacterial assays using Staphylococcus aureus, Candida albicans, and Mycobacteria have been carried out but did not reveal significant activity.
Kunert
Olaf
O
Institute of Pharmaceutical Sciences, Karl-Franzens-University Graz, Graz.
Sreekanth
Gandhe
G
Babu
Gummadi Sreedhar
GS
Rao
Belvotagi Venkat Rao Adavi
BV
Radhakishan
Marupaka
M
Kumar
Bobbala Ravi
BR
Saf
Robert
R
Rao
Achanta Venkata Narasimha Appa
AV
Schühly
Wolfgang
W
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D032062:Gardenia / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D053149:Plant Gums / Q000737:chemistry*; D012116:Resins, Plant / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D053149:Plant Gums; D012116:Resins, Plant; D014315:Triterpenes