title: E2F and retinoblastoma related proteins may regulate GL1 expression in developing Arabidopsis trichomes.
abstract: This is an addendum to our recent paper published in The Plant Journal (52:352-61). The major findings were: (1) trichomes on the leaves of gl3-sst sim double mutants developed as large multi-cellular clusters whereas wild type trichomes are composed of single cells; (2) ectopic CYCD3;1 expression in gl3-sst trichomes also resulted in trichome cluster formation; and (3) that GL1 expression is prolonged in the gl3-sst sim trichome clusters. This addendum shows that ectopic CYCD3;1 expression in gl3-sst also enhanced GL1 expression. An analysis of the GL1 promoter found two overlapping potential E2F binding sites in a region of the promoter known to be essential for GL1 function. This finding indicates that GL1 may be directly regulated by the activity of a CYCD3/CDKA complex that phosphorylates E2F-RB bound to the GL1 promoter.
authors.affiliation: Department of Plant Biology; University of Minnesota; St. Paul, Minnesota USA.
authors.forename: Jonathan P
authors.initials: JP
authors.lastname: Wenger
authors.forename: M David
authors.initials: MD
authors.lastname: Marks
references.citation: Cell. 1991 Nov 1;67(3):483-93
references.pmid: 1934056
references.citation: Development. 2003 Oct;130(20):4859-69
references.pmid: 12917293
references.citation: Cell. 1994 Feb 11;76(3):555-66
references.pmid: 8313475
references.citation: Plant Cell. 1993 Dec;5(12):1739-1748
references.pmid: 12271054
references.citation: Plant Physiol. 2007 May;144(1):105-20
references.pmid: 17351056
references.citation: Int J Dev Biol. 2005;49(5-6):579-84
references.pmid: 16096966
references.citation: Plant Cell. 1999 Jul;11(7):1337-50
references.pmid: 10402433
references.citation: Development. 2000 Sep;127(18):3931-40
references.pmid: 10952891
references.citation: Curr Opin Plant Biol. 2003 Feb;6(1):74-8
references.pmid: 12495754
references.citation: Philos Trans R Soc Lond B Biol Sci. 2002 Jun 29;357(1422):823-6
references.pmid: 12079678
references.citation: Annu Rev Genet. 2006;40:77-105
references.pmid: 17094738
references.citation: Trends Plant Sci. 2000 May;5(5):214-9
references.pmid: 10785667
references.citation: Plant Cell. 2002 Aug;14(8):1847-57
references.pmid: 12172026
references.citation: Plant Physiol. 2005 Sep;139(1):316-28
references.pmid: 16126853
references.citation: Plant Cell. 2006 Nov;18(11):3145-57
references.pmid: 17098811
references.citation: EMBO J. 2002 Oct 1;21(19):5036-46
references.pmid: 12356720
references.citation: Proc Natl Acad Sci U S A. 2002 Apr 30;99(9):6410-5
references.pmid: 11983922
references.citation: Development. 1998 Apr;125(7):1161-71
references.pmid: 9477315
references.citation: Genetics. 2000 Nov;156(3):1349-62
references.pmid: 11063707
references.citation: Trends Plant Sci. 2002 Nov;7(11):505-11
references.pmid: 12417151
references.citation: Development. 2003 Dec;130(24):5885-94
references.pmid: 14561633
references.citation: Plant J. 2004 Dec;40(6):860-9
references.pmid: 15584952
references.citation: Plant J. 1999 May;18(3):243-52
references.pmid: 10377991
references.citation: Plant J. 2007 Oct;52(2):352-61
references.pmid: 17764505