title: Continued effects of prenatal cocaine use: preschool development.
abstract: The relationship between prenatal cocaine use and preschooler's physical and cognitive development and behavioral characteristics was examined, controlling for other influences on child development. On average, children were 38.5 months old, women were 29.4 years old, had 12.3 years of education, and 47% were African American. During the first trimester, 18% of the women were frequent cocaine users (> or = 1 line/day). First trimester cocaine exposure predicted decreased head circumference at 3 years and lower scores on the short-term memory subscale of the Stanford-Binet Intelligence Scale (SBIS) [74]. There was no significant relationship between prenatal cocaine use and the other SBIS scales. First trimester cocaine use also predicted more total, internalizing, and externalizing behavior problems on the Child Behavior Checklist [3] and higher scores on the fussy/difficult scale of the Infant Characteristics Questionnaire [6]. Children who were exposed to cocaine throughout pregnancy had more behavior problems and were more fussy compared to children of women who never used cocaine prenatally. A repeated measures analysis showed that children of first trimester cocaine users became more fussy over time. These detrimental effects on growth and behavior are consistent with other reports in the literature and with the hypothesis that prenatal cocaine exposure affects development through changes in neurotransmitter systems.
authors.affiliation: University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O'Hara Street, Pittsburgh, PA 15213, USA. gar@pitt.edu
authors.forename: Gale A
authors.initials: GA
authors.lastname: Richardson
authors.forename: Lidush
authors.initials: L
authors.lastname: Goldschmidt
authors.forename: Jennifer
authors.initials: J
authors.lastname: Willford
mesh_terms: D000328:Adult; D000368:Aged; D001827:Body Height / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002653:Child Behavior Disorders / Q000139:chemically induced; D002657:Child Development / Q000187:drug effects*; D002675:Child, Preschool; D003042:Cocaine / Q000633:toxicity*; D019970:Cocaine-Related Disorders / Q000523:psychology*; D003071:Cognition / Q000187:drug effects; D005260:Female; D006257:Head / Q000033:anatomy & histology; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D011247:Pregnancy; D011248:Pregnancy Complications; D011261:Pregnancy Trimester, First; D011297:Prenatal Exposure Delayed Effects / Q000523:psychology*
chemical_list: D003042:Cocaine
references.citation: Neurotoxicol Teratol. 2005 Jan-Feb;27(1):15-28
references.pmid: 15681118
references.citation: Pediatrics. 2004 Jun;113(6):1677-85
references.pmid: 15173491
references.citation: J Dev Behav Pediatr. 2007 Jun;28(3):195-205
references.pmid: 17565286
references.citation: Pediatrics. 1989 Sep;84(3):536-41
references.pmid: 2771556
references.citation: Psychopharmacology (Berl). 1993;112(4):445-51
references.pmid: 7871055
references.citation: Neurotoxicol Teratol. 1999 Sep-Oct;21(5):513-25
references.pmid: 10492386
references.citation: J Clin Invest. 1994 Mar;93(3):1179-85
references.pmid: 8132758
references.citation: J Dev Behav Pediatr. 2003 Oct;24(5):345-51
references.pmid: 14578695
references.citation: Dev Psychopathol. 1997 Summer;9(3):473-89
references.pmid: 9327234
references.citation: J Pediatr Psychol. 2006 Jan-Feb;31(1):71-84
references.pmid: 15827351
references.citation: JAMA. 2004 May 26;291(20):2448-56
references.pmid: 15161895
references.citation: Ann N Y Acad Sci. 1998 Jun 21;846:165-81
references.pmid: 9668406
references.citation: J Dev Behav Pediatr. 2000 Feb;21(1):19-26
references.pmid: 10706345
references.citation: N Engl J Med. 1989 Mar 23;320(12):762-8
references.pmid: 2784193
references.citation: J Dev Behav Pediatr. 2006 Apr;27(2):83-92
references.pmid: 16682870
references.citation: J Pharmacol Exp Ther. 1992 Nov;263(2):413-21
references.pmid: 1331397
references.citation: J Pers Soc Psychol. 2004 Jan;86(1):112-29
references.pmid: 14717631
references.citation: Pediatrics. 2007 Oct;120(4):e1017-27
references.pmid: 17893189
references.citation: Clin Invest Med. 2001 Jun;24(3):129-37
references.pmid: 11437064
references.citation: Neurotoxicol Teratol. 2007 May-Jun;29(3):331-40
references.pmid: 17258430
references.citation: J Dev Behav Pediatr. 1999 Dec;20(6):418-24
references.pmid: 10608371
references.citation: J Child Psychol Psychiatry. 1994 Sep;35(6):1109-22
references.pmid: 7995846
references.citation: Brain Res Dev Brain Res. 1995 Mar 16;85(1):48-53
references.pmid: 7781166
references.citation: Pediatrics. 2007 Feb;119(2):e348-59
references.pmid: 17272597
references.citation: J Am Acad Child Adolesc Psychiatry. 1997 Mar;36(3):374-83
references.pmid: 9055518
references.citation: J Am Acad Child Adolesc Psychiatry. 2001 Jan;40(1):36-43
references.pmid: 11195559
references.citation: J Pediatr Psychol. 2004 Oct;29(7):543-54
references.pmid: 15347702
references.citation: Pediatrics. 2001 Feb;107(2):309-17
references.pmid: 11158464
references.citation: Dev Psychol. 2008 Jul;44(4):919-28
references.pmid: 18605824
references.citation: Drug Alcohol Depend. 1998 Jun-Jul;51(1-2):109-25
references.pmid: 9716934
references.citation: J Neurosci. 1990 Jul;10(7):2125-38
references.pmid: 2165520
references.citation: Adv Data. 2000 Jun 8;(314):1-27
references.pmid: 11183293
references.citation: Neurotoxicol Teratol. 1996 Sep-Oct;18(5):519-28
references.pmid: 8888016
references.citation: Neurotoxicol Teratol. 1994 Jan-Feb;16(1):81-7
references.pmid: 8183193
references.citation: Neurotoxicol Teratol. 2008 Mar-Apr;30(2):96-106
references.pmid: 18243651
references.citation: Dev Neurosci. 2009;31(1-2):149-58
references.pmid: 19372695
references.citation: J Pediatr Psychol. 2002 Apr-May;27(3):259-69
references.pmid: 11909933
references.citation: Dev Psychol. 2002 Sep;38(5):648-58
references.pmid: 12220044
references.citation: Pediatrics. 2000 Jan;105(1 Pt 1):39-48
references.pmid: 10617702
references.citation: Dev Psychol. 2006 Jul;42(4):688-97
references.pmid: 16802901
references.citation: J Am Acad Child Adolesc Psychiatry. 1987 Jul;26(4):491-8
references.pmid: 3654499
references.citation: Child Dev. 1979 Sep;50(3):794-803
references.pmid: 498854
references.citation: Acta Paediatr Suppl. 1994 Dec;406:3-9; discussion 10
references.pmid: 7734809
references.citation: J Dev Behav Pediatr. 2004 Feb;25(1):1-9
references.pmid: 14767350
references.citation: Child Dev. 1996 Apr;67(2):396-408
references.pmid: 8625720
references.citation: Crit Rev Neurobiol. 1995;9(4):395-418
references.pmid: 8829853
references.citation: Am J Drug Alcohol Abuse. 2004 May;30(2):299-320
references.pmid: 15230078
references.citation: Neurosci Biobehav Rev. 2004 Jan;27(8):751-64
references.pmid: 15019425
references.citation: Neurotoxicol Teratol. 1994 Mar-Apr;16(2):169-75
references.pmid: 8052191
references.citation: Pediatrics. 1999 Aug;104(2):e18
references.pmid: 10429136
references.citation: Neurotoxicol Teratol. 1991 May-Jun;13(3):329-34
references.pmid: 1886543
references.citation: Neurotoxicol Teratol. 2001 Nov-Dec;23(6):545-59
references.pmid: 11792524
references.citation: J Pediatr Psychol. 2006 Jan-Feb;31(1):41-9
references.pmid: 15827349
references.citation: Neurotoxicol Teratol. 1992 Nov-Dec;14(6):407-14
references.pmid: 1488035
references.citation: Neurotoxicol Teratol. 2002 Nov-Dec;24(6):703-10
references.pmid: 12460652
references.citation: J Am Acad Child Adolesc Psychiatry. 1994 Jan;33(1):20-7
references.pmid: 7511139
references.citation: Cell Tissue Res. 2001 Aug;305(2):177-86
references.pmid: 11545255
references.citation: Ann N Y Acad Sci. 1989;562:8-13
references.pmid: 2742287
references.citation: Neurotoxicol Teratol. 2007 Jul-Aug;29(4):446-57
references.pmid: 17412558
references.citation: J Dev Behav Pediatr. 2001 Feb;22(1):27-34
references.pmid: 11265920
references.citation: Clin Obstet Gynecol. 1993 Jun;36(2):302-18
references.pmid: 8513626
references.citation: Ann N Y Acad Sci. 1998 Jun;846(1):158-164
references.pmid: 29087559