title: Association between hepatic lipase -514 C/T promoter polymorphism and myocardial infarction is modified by history of hypercholesterolemia and waist circumference.
abstract: OBJECTIVE
  To examine whether the association between the -514 C/T polymorphism of the hepatic lipase gene and myocardial infarction (MI) is modified by history of hypercholesterolemia and increased waist circumference.
  
  
  RESULTS
  A total of 1940 pairs of nonfatal MI cases and population-based controls were genotyped. Multiple conditional logistic regression was used for data analyses. The -514T variant was not associated with MI in the whole population. However, among people with history of hypercholesterolemia the T allele increased MI risk for heterozygous and homozygous carriers, respectively [OR=1.25 (95%CI=0.92-1.70) and OR=1.59 (95%CI=1.09-2.32). In contrast, the T allele decreased MI risk among people with no history of hypercholesterolemia [OR=0.85 (95%CI=0.70-1.03) and OR=0.76 (95%CI=0.60-0.97)], p for interaction=0.004. Among subjects with normal waist circumference there was no association between the -514T allele and MI for heterozygous and homozygous carriers, respectively [OR=1.04 (95%CI=0.86-1.25) and OR=0.96 (95%CI=0.77-1.21)], while among subjects with waist circumference above the limits of the metabolic syndrome definition there was a protective association [OR=0.63 (95%CI=0.45-0.90) and OR=0.81 (95%CI=0.53-1.25) p for interaction=0.04].
  
  
  CONCLUSIONS
  The -514T allele is associated with MI in opposite directions depending on the background of the studied population. This could explain what seem like inconsistent results across studies.
authors.affiliation: Department of Community Health, Warren Alpert Medical School, Brown University, Providence, RI 0203, USA. ana_baylin@brown.edu
authors.forename: A
authors.initials: A
authors.lastname: Baylin
authors.forename: E
authors.initials: E
authors.lastname: Ruiz-Narvaez
authors.forename: M K
authors.initials: MK
authors.lastname: Jensen
authors.forename: E
authors.initials: E
authors.lastname: Rimm
authors.forename: H
authors.initials: H
authors.lastname: Campos
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D003364:Costa Rica; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D006937:Hypercholesterolemia / Q000150:complications*; D016013:Likelihood Functions; D008049:Lipase / Q000235:genetics*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000201:enzymology / Q000235:genetics*; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D018570:Risk Assessment; D012307:Risk Factors; D055105:Waist Circumference
chemical_list: C504173:LIPC protein, human; D008049:Lipase
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