Bordetella pertussis infection or vaccination substantially protects mice against B. bronchiseptica infection.
Although B. bronchiseptica efficiently infects a wide range of mammalian hosts and efficiently spreads among them, it is rarely observed in humans. In contrast to the many other hosts of B. bronchiseptica, humans are host to the apparently specialized pathogen B. pertussis, the great majority having immunity due to vaccination, infection or both. Here we explore whether immunity to B. pertussis protects against B. bronchiseptica infection. In a murine model, either infection or vaccination with B. pertussis induced antibodies that recognized antigens of B. bronchiseptica and protected the lower respiratory tract of mice against three phylogenetically disparate strains of B. bronchiseptica that efficiently infect naïve animals. Furthermore, vaccination with purified B. pertussis-derived pertactin, filamentous hemagglutinin or the human acellular vaccine, Adacel, conferred similar protection against B. bronchiseptica challenge. These data indicate that individual immunity to B. pertussis affects B. bronchiseptica infection, and suggest that the high levels of herd immunity against B. pertussis in humans could explain the lack of observed B. bronchiseptica transmission. This could also explain the apparent association of B. bronchiseptica infections with an immunocompromised state.
Goebel
Elizabeth M
EM
Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, Pennsylvania, USA.
Zhang
Xuqing
X
Harvill
Eric T
ET
D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology; D001885:Bordetella Infections / Q000382:microbiology / Q000517:prevention & control*; D016950:Bordetella bronchiseptica / Q000472:pathogenicity*; D001886:Bordetella pertussis / Q000276:immunology* / Q000472:pathogenicity; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL
D000942:Antigens, Bacterial
Infect Immun. 2003 Apr;71(4):1719-24
12654784
J Gen Microbiol. 1970 Oct;63(2):211-20
4324651
Microbes Infect. 2001 Jan;3(1):61-72
11226855
Scand J Infect Dis. 1999;31(3):281-6
10482058
Infect Immun. 2007 Sep;75(9):4416-22
17591791
Clin Infect Dis. 1995 Jan;20(1):193-4
7727654
J Clin Microbiol. 1995 Aug;33(8):2002-6
7559937
Expert Rev Vaccines. 2007 Feb;6(1):47-56
17280478
Immunology. 2002 Mar;105(3):286-94
11918690
PLoS Pathog. 2005 Dec;1(4):e45
16389302
Microbiol Mol Biol Rev. 2008 Sep;72(3):457-70
18772285
Emerg Infect Dis. 1999 May-Jun;5(3):441-3
10341183
Pediatr Infect Dis J. 1995 Mar;14(3):209-14
7761186
Annu Rev Microbiol. 2002;56:539-65
12142495
Infect Immun. 2005 Oct;73(10):6508-13
16177324
PLoS Pathog. 2005 Sep;1(1):e1
16201010
J Clin Microbiol. 1988 Dec;26(12):2558-60
2906641
Infect Immun. 1999 Nov;67(11):6109-18
10531274
Cent Eur J Public Health. 2003 Dec;11 Suppl:S17-22
15080254
J Bacteriol. 2008 Aug;190(15):5502-11
18556799
JAMA. 1998 Aug 19;280(7):635-7
9718056
Microbes Infect. 2007 Apr;9(4):442-8
17317263
Rev Infect Dis. 1991 Jul-Aug;13(4):771-2
1925302
Vaccine. 1998 Feb;16(4):410-6
9607064
Pediatr Infect Dis J. 2003 Apr;22(4):380-1
12712975
Microbiol Rev. 1980 Dec;44(4):722-38
7010115
Clin Microbiol Rev. 2005 Apr;18(2):326-82
15831828
J Clin Microbiol. 2002 Sep;40(9):3146-54
12202545
Immunopharmacology. 1999 May;42(1-3):135-49
10408374
J Clin Microbiol. 1998 Apr;36(4):999-1002
9542925
Clin Microbiol Rev. 1991 Jul;4(3):243-55
1889042
Pediatrics. 1998 Jan;101(1 Pt 1):1-11
9417143
Infection. 2005 Feb;33(1):13-7
15750754
J Immunol. 2005 Dec 1;175(11):7504-11
16301658
Infect Immun. 1998 Dec;66(12):5921-9
9826374
J Clin Microbiol. 1983 May;17(5):781-6
6306047
Expert Rev Anti Infect Ther. 2004 Jun;2(3):447-54
15482209
Science. 2006 Apr 21;312(5772):394-7
16627737
P R Health Sci J. 2005 Sep;24(3):197-202
16331860
Infect Immun. 2002 May;70(5):2598-604
11953401
Vaccine. 2000 Dec 8;19(9-10):1118-28
11137247
Infect Immun. 2007 Oct;75(10):4972-9
17698566
Vaccine. 2004 May 7;22(15-16):1892-8
15121300
Eur J Immunol. 2004 Jan;34(1):184-93
14971044
Infect Immun. 1994 Aug;62(8):3381-90
8039908
Infect Immun. 2000 Dec;68(12):6511-8
11083759
Arch Bronconeumol. 2006 May;42(5):255-6
16740243
Arch Dis Child. 2003 Aug;88(8):684-7
12876162
Crit Rev Microbiol. 2007;33(4):243-99
18033595
Clin Infect Dis. 1999 Mar;28(3):602-4
10194085
Trends Microbiol. 2005 Aug;13(8):355-9
15990312
Infect Immun. 1998 Oct;66(10):4579-87
9746553
Proc Biol Sci. 2006 Feb 22;273(1585):409-16
16615206
J Bacteriol. 1991 Jul;173(14):4288-96
2066330