High doses of GnRH antagonists are efficient in the management of severe ovarian hyperstimulation syndrome.
OBJECTIVE
To determine whether treatment of severe ovarian hyperstimulation syndrome (OHSS) with high-dose gonadotropin-releasing hormone (GnRH) antagonist, due to its luteolytic effect, is an effective method of management.


METHODS
Six infertile patients who had been scheduled for embryo transfer and developed early-onset severe OHSS with ascites and hemoconcentration were chosen for treatment with 3.0 mg of a GnRH antagonist (Cetrotide; Cetrorelix, Serono, Madrid, Spain). The response of these patients was compared with five patients with severe early-onset OHSS who received support therapy alone. All patients were evaluated clinically, echographically, and hematologically.


RESULTS
Estradiol (E2) levels dropped significantly a few days after treatment. Peritoneal fluid regression measured by ultrasound was faster on the study group compared with controls. Hematocrit remained comparable in both groups during follow-up. In two cases a second bolus of GnRH-antagonist was used due to clinical and biochemical findings during the four days of observation following the initial dose. None of the patients treated with GnRH antagonists required paracentesis.


CONCLUSIONS
Treatment with high doses of GnRH antagonists seems to be effective in the management of severe OHSS.
Bonilla-Musoles
F M
FM
Department of Obstetrics and Gynecology, Valencia University Faculty of Medicine, Valencia, Spain. bonilla_fer@gva.es
Raga
F
F
Castillo
J C
JC
Sanz
M
M
Dolz
M
M
Osborne
N
N
D000328:Adult; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors*; D006727:Hormone Antagonists / Q000008:administration & dosage*; D006801:Humans; D016471:Ovarian Hyperstimulation Syndrome / Q000188:drug therapy*; D010865:Pilot Projects
D006727:Hormone Antagonists; D007987:Gonadotropin-Releasing Hormone; C062876:cetrorelix