title: Metalloproteins and metal sensing.
abstract: Almost half of all enzymes must associate with a particular metal to function. An ambition is to understand why each metal-protein partnership arose and how it is maintained. Metal availability provides part of the explanation, and has changed over geological time and varies between habitats but is held within vital limits in cells. Such homeostasis needs metal sensors, and there is an ongoing search to discover the metal-sensing mechanisms. For metalloproteins to acquire the right metals, metal sensors must correctly distinguish between the inorganic elements.
authors.affiliation: Cell & Molecular Biosciences, Medical School, Newcastle University, Newcastle NE2 4HH, UK.
authors.forename: Kevin J
authors.initials: KJ
authors.lastname: Waldron
authors.forename: Julian C
authors.initials: JC
authors.lastname: Rutherford
authors.forename: Dianne
authors.initials: D
authors.lastname: Ford
authors.forename: Nigel J
authors.initials: NJ
authors.lastname: Robinson
mesh_terms: D000494:Allosteric Regulation; D000818:Animals; D001419:Bacteria / Q000378:metabolism; D055162:Biocatalysis; D015870:Gene Expression; D008667:Metalloproteins / Q000378:metabolism*; D008670:Metals / Q000378:metabolism*; D020871:RNA Stability; D015003:Yeasts / Q000378:metabolism
chemical_list: D008667:Metalloproteins; D008670:Metals
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