Regulation of spermatogenesis in the microenvironment of the seminiferous epithelium: new insights and advances.
Spermatogenesis is a complex biochemical event, involving the participation of the hypothalamus and the pituitary gland via secretion of the hypothalamus hormone GnRH, and two pituitary hormones FSH and LH. Thus, the hypothalamic-pituitary-testicular axis is a crucial regulatory axis for testicular function. Recent studies have shown that in the microenvironment of the seminiferous epithelium, wherein each Sertoli cell supports approximately 30-50 germ cells at different stages of development, locally produced autocrine and paracrine factors are also involved in spermatogenesis, in particular at the level of cell junctions. These cell junctions at the Sertoli-Sertoli and Sertoli-germ cell interface are crucial for coordinating different events of spermatogenesis by sending signals back-and-forth between Sertoli and germ cells, in order to precisely regulate spermatogonial cell renewal by mitosis, cell cycle progression, meiosis, spermiogenesis, germ cell movement across the epithelium, spermiation and germ cell apoptosis. In this minireview, we provide an update on these latest findings for an emerging new concept regarding the presence of a local "apical ectoplasmic specialization-blood-testis barrier-hemidesmosome/basement membrane" functional axis that regulates the events of spermiation and blood-testis barrier (BTB) restructuring via paracrine/autocrine factors and polarity proteins produced locally in the seminiferous epithelium. These findings provide a new window of research for investigators in the field to tackle the functional regulation of spermatogenesis.
Cheng
C Yan
CY
Center for Biomedical Research, Population Council, 1230 York Avenue, New York, NY 10065, USA. Y-Cheng@popcbr.rockefeller.edu
Wong
Elissa W P
EW
Yan
Helen H N
HH
Mruk
Dolores D
DD
D000818:Animals; D001485:Basement Membrane / Q000378:metabolism; D001814:Blood-Testis Barrier / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D005854:Germ Cells / Q000502:physiology; D007365:Intercellular Junctions / Q000378:metabolism; D008297:Male; D012670:Seminiferous Epithelium / Q000166:cytology / Q000502:physiology*; D012708:Sertoli Cells / Q000166:cytology / Q000502:physiology; D013091:Spermatogenesis / Q000502:physiology*; D013739:Testosterone / Q000378:metabolism
D016207:Cytokines; D013739:Testosterone
Biol Reprod. 1993 Oct;49(4):840-9
8218650
Biol Reprod. 2004 Apr;70(4):945-64
14645107
Dev Biol. 2009 Mar 1;327(1):48-61
19103189
Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9657-62
18621709
Endocrinology. 2006 Dec;147(12):5624-33
16973730
Int J Androl. 2003 Jun;26(3):147-60
12755993
Semin Cell Dev Biol. 1998 Aug;9(4):417-21
9813188
Microsc Res Tech. 2009 Aug;72(8):620-8
19263422
J Endocrinol. 2006 Aug;190(2):313-29
16899565
Biol Reprod. 1998 Feb;58(2):371-8
9475391
Proc Natl Acad Sci U S A. 2009 Jun 23;106(25):10213-8
19509333
Endocrinology. 1993 Jul;133(1):389-96
8319585
Clin Immunol Immunopathol. 1992 Jan;62(1 Pt 2):S3-10
1728986
Adv Exp Med Biol. 2008;636:212-33
19856170
Proc Natl Acad Sci U S A. 1975 Sep;72(9):3666-70
1103152
Cell. 1996 Jan 26;84(2):299-308
8565075
Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9298-303
19470647
Mol Cell Biol. 2004 Apr;24(7):2593-604
15024051
Endocrinology. 2005 Mar;146(3):1268-84
15591133
Endocrinology. 2003 May;144(5):2141-63
12697723
Toxicol Appl Pharmacol. 2009 Aug 1;238(3):240-9
19236889
Hum Reprod. 2008 Aug;23(8):1865-72
18579514
J Cell Sci. 2004 Feb 15;117(Pt 5):783-98
14734653
Biol Reprod. 1992 Dec;47(6):1173-82
1283530
Endocrinology. 1995 Aug;136(8):3519-26
7628389
Biol Reprod. 2003 May;68(5):1597-612
12606350
Biol Reprod. 2003 Apr;68(4):1299-307
12606480
Endocrinology. 2001 May;142(5):1865-77
11316752
J Steroid Biochem Mol Biol. 1995 Jun;53(1-6):215-8
7626457
Reprod Biol Endocrinol. 2003 Jul 09;1:52
12904263
Sci STKE. 2007 Apr 10;2007(381):re3
17426346
Exp Cell Res. 1961;Suppl 8:174-87
13698424
Int J Androl. 2007 Aug;30(4):377-84; discussion 384
17705810
FASEB J. 2008 Jun;22(6):1945-59
18192323
Ann N Y Acad Sci. 2005 Dec;1061:208-20
16467270
Endocrinology. 2001 May;142(5):1878-88
11316753
Endocrinology. 1993 Jun;132(6):2438-44
8504748
Proc Natl Acad Sci U S A. 2008 Jul 1;105(26):8950-5
18579774
Endocrinology. 2009 Jul;150(7):3336-44
19213829
Endocrinology. 2003 Apr;144(4):1139-42
12639893
Curr Top Dev Biol. 2008;80:57-92
17950372
Endocr Rev. 1982 Fall;3(4):404-17
6295753
J Immunol. 2000 Jul 15;165(2):743-9
10878347
Endocr Rev. 2004 Oct;25(5):747-806
15466940
Physiol Rev. 1972 Jan;52(1):198-236
4621362
J Biol Chem. 2006 Jun 23;281(25):17286-17303
16608848
Biochem Biophys Res Commun. 1996 Jul 25;224(3):631-7
8713100
Ann N Y Acad Sci. 1952 Nov 20;55(4):548-73
13139144
Endocrinology. 1984 Nov;115(5):1925-32
6541571
J Endocrinol. 1970 May;47(1):81-6
5428920
Endocrinology. 1997 Mar;138(3):1097-105
9048615
Steroids. 2009 Jul;74(7):602-7
19095000
Endocr Rev. 1994 Feb;15(1):102-15
8156935
Adv Exp Med Biol. 2008;636:92-114
19856164
J Biol Chem. 2006 Jun 16;281(24):16799-813
16617054
Mol Cell Endocrinol. 2003 Mar 28;201(1-2):1-12
12706288
Endocrinology. 2003 Jan;144(1):371-87
12488366
Endocrinology. 2009 Oct;150(10):4713-23
19608648
Biochim Biophys Acta. 2008 Mar;1778(3):692-708
18068662
Endocrinology. 1998 Jun;139(6):2863-8
9607795
Endocrinology. 1991 Sep;129(3):1489-96
1908377
Apoptosis. 2007 Sep;12(9):1681-90
17520191
Pharmacol Rev. 2008 Jun;60(2):146-80
18483144
Physiol Rev. 2002 Oct;82(4):825-74
12270945
Bioessays. 2004 Sep;26(9):978-92
15351968
J Endocrinol. 2006 Sep;190(3):759-70
17003277
J Cell Physiol. 2005 Oct;205(1):141-57
15880438
Proc Natl Acad Sci U S A. 2005 Nov 15;102(46):16696-700
16275920
Microsc Res Tech. 2000 Aug 1;50(3):184-95
10891884
Bioessays. 2007 Jan;29(1):36-48
17187371