Computerized cognitive assessment of mild cognitive impairment in urban African Americans.
Few objective cognitive assessment tools have been validated for mild cognitive impairment (MCI) in African Americans despite higher prevalence of disease. This preliminary study evaluated discriminant validity of a computerized cognitive assessment battery for MCI in an urban African American cohort. Twenty-seven participants with MCI and 22 cognitively healthy individuals completed a multidomain battery (Mindstreams, NeuroTrax Corp, New Jersey). Mild cognitive impairment participants performed more poorly than cognitively healthy participants in all domains, with significant differences in memory (P = .003; d = 0.96), executive function (P = .046; d = 0.64), and overall battery performance (P = .041; d = 0.63). Adjustment for intelligence quotient (IQ) yielded significant differences in memory (P < .001; d = 1.34), executive function (P = .007; d = 0.86), attention (P = .014; d = .80), and overall performance (P = .001; d = 1.09). Such a validated battery may help to address an important clinical need in this population.
Doniger
Glen M
GM
Department of Clinical Science, NeuroTrax Corporation, Newark, New Jersey 07103, USA. glen.doniger@neurotrax.com
Jo
Mi-Yeoung
MY
Simon
Ely S
ES
Crystal
Howard A
HA
D000328:Adult; D001741:Black or African American / Q000706:statistics & numerical data; D000368:Aged; D003072:Cognition Disorders / Q000175:diagnosis* / Q000208:ethnology; D003936:Diagnosis, Computer-Assisted / Q000379:methods* / Q000592:standards; D005260:Female; D006801:Humans; D007361:Intelligence Tests; D008297:Male; D008568:Memory; D009483:Neuropsychological Tests; D015995:Prevalence; D015203:Reproducibility of Results; D012720:Severity of Illness Index; D012984:Software; D014505:Urban Population / Q000706:statistics & numerical data; D014706:Verbal Learning
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