Mechanisms of gap junction traffic in health and disease.
Gap junctions (GJs) allow direct communication between cells. In the heart, GJs mediate the electrical coupling of cardiomyocytes and as such dictate the speed and direction of cardiac conduction. A prominent feature of acquired structural heart disease is remodeling of GJ protein expression and localization concomitant with increased susceptibility to lethal arrhythmias, leading many to hypothesize that the two are causally linked. Detailed understanding of the cellular mechanisms that regulate GJ localization and function within cardiomyocytes may therefore uncover potential therapeutic strategies for a significant clinical problem. This review will outline our current understanding of GJ cell biology with the intent of highlighting cellular mechanisms responsible for GJ remodeling associated with cardiac disease.
Hesketh
Geoffrey G
GG
Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Van Eyk
Jennifer E
JE
Tomaselli
Gordon F
GF
D000818:Animals; D002450:Cell Communication / Q000502:physiology; D017630:Connexins / Q000378:metabolism; D017629:Gap Junctions / Q000378:metabolism / Q000502:physiology* / Q000648:ultrastructure; D006329:Heart Conduction System / Q000502:physiology; D006331:Heart Diseases / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D032383:Myocytes, Cardiac / Q000378:metabolism / Q000502:physiology; D010766:Phosphorylation; D054730:Protein Interaction Domains and Motifs
D017630:Connexins
Circ Res. 2004 Feb 6;94(2):215-22
14699011
J Cell Biol. 2002 Apr 29;157(3):381-94
11980915
Curr Biol. 2001 Sep 4;11(17):1364-8
11553331
J Biol Chem. 2005 May 20;280(20):19925-36
15741167
J Mol Cell Cardiol. 2008 Mar;44(3):597-606
18201716
Mol Biol Cell. 1992 Aug;3(8):865-74
1327298
Science. 1995 Mar 24;267(5205):1831-4
7892609
J Cell Sci. 2008 Dec 15;121(Pt 24):4069-78
19033388
J Cell Sci. 2004 Apr 15;117(Pt 10):2087-96
15054109
Am J Physiol Cell Physiol. 2003 Feb;284(2):C511-20
12388103
Mol Cell Biol. 2007 Nov;27(21):7522-37
17785437
Science. 1988 Jan 22;239(4838):398-401
2447651
J Cell Biol. 2007 Dec 17;179(6):1301-9
18086922
J Cell Physiol. 2002 Dec;193(3):373-9
12384989
J Biol Chem. 2001 Mar 16;276(11):8544-9
11124251
Neurobiol Dis. 2002 Oct;11(1):43-52
12460545
Mol Biol Cell. 2003 Jun;14(6):2470-81
12808044
Cell Commun Adhes. 2001;8(4-6):219-23
12064592
Biochim Biophys Acta. 2005 Jun 10;1711(2):172-82
15955302
Circ Res. 2002 Oct 4;91(7):640-7
12364393
J Biol Chem. 2004 Dec 24;279(52):54695-701
15492000
J Cell Sci. 2004 Mar 1;117(Pt 7):1211-20
14970263
J Biol Chem. 2003 May 16;278(20):18682-8
12637502
J Cell Biol. 2007 Jun 4;177(5):881-91
17535964
Cell Commun Adhes. 2008 May;15(1):65-74
18649179
Biochem J. 2006 Jan 1;393(Pt 1):59-67
16162097
Cell Commun Adhes. 2003 Jul-Dec;10(4-6):329-33
14681037
Exp Cell Res. 1997 Nov 1;236(2):482-92
9367633
J Cell Mol Med. 2001 Oct-Dec;5(4):355-66
12067469
Science. 2002 Apr 19;296(5567):503-7
11964472
Cardiovasc Pathol. 2007 May-Jun;16(3):159-64
17502245
Circ Res. 2004 Oct 1;95(7):717-25
15345654
J Cell Sci. 2005 Oct 1;118(Pt 19):4451-62
16159960
Cell Commun Adhes. 2007 Sep-Oct;14(5):211-26
18163231
J Cell Sci. 2001 Mar;114(Pt 6):1229-35
11228166
Circ Res. 2005 Sep 2;97(5):474-81
16100040
J Cell Sci. 1995 Sep;108 ( Pt 9):3079-90
8537447
Circ Res. 1998 Jul 13;83(1):27-32
9670915
Cell Regul. 1990 Dec;1(13):989-1002
1966893
Heart Rhythm. 2004 May;1(1):3-11
15851108
Mol Cell Biol. 1990 Apr;10(4):1754-63
1690850
Cell Commun Adhes. 2008 May;15(1):75-84
18649180
J Biol Chem. 1998 May 22;273(21):12725-31
9582296
J Biol Chem. 2002 Jun 7;277(23):20911-8
11929864
Circ Res. 2002 Feb 22;90(3):317-24
11861421
Dev Biol. 1996 Oct 10;179(1):1-16
8873750
Am J Physiol Heart Circ Physiol. 2004 May;286(5):H2001-9
14704225
J Cell Sci. 2000 Sep;113 ( Pt 17):3037-49
10934042
Prog Biophys Mol Biol. 2007 May-Jun;94(1-2):107-19
17507079
Circ Res. 1999 Oct 15;85(8):672-81
10521240
Mol Biol Cell. 2000 Jun;11(6):1933-46
10848620
Cell. 2007 Feb 9;128(3):547-60
17289573
Cardiovasc Res. 2008 Oct 1;80(1):9-19
18519446
Am J Physiol Heart Circ Physiol. 2004 Oct;287(4):H1762-70
15205174
J Cell Biol. 2001 Aug 20;154(4):815-27
11514593
Cardiovasc Res. 2008 Mar 1;77(4):757-65
18056766
J Biol Chem. 1996 Feb 16;271(7):3779-86
8631994
FEBS Lett. 2008 Aug 20;582(19):2887-92
18656476
J Cell Sci. 2003 Jun 1;116(Pt 11):2213-22
12730291
Eur J Neurosci. 2004 Apr;19(8):2132-46
15090040
FEBS Lett. 2008 Dec 10;582(29):4039-46
18992245
Neuron. 2005 Jun 2;46(5):731-44
15924860
J Biol Chem. 2002 Mar 22;277(12):10482-8
11790776
J Cell Biol. 1986 Sep;103(3):755-66
3528172
Cardiovasc Res. 2005 Aug 15;67(3):539-47
15913582
J Cell Biol. 1999 Mar 8;144(5):1033-45
10085299
J Biol Chem. 2003 Aug 8;278(32):30005-14
12767974
Mol Biol Cell. 1999 Jun;10(6):2033-50
10359613
J Cell Sci. 2006 Sep 1;119(Pt 17):3634-42
16931598
Neuroscience. 2004;126(3):611-30
15183511
J Biol Chem. 2008 Feb 29;283(9):5748-59
18079109
FEBS Lett. 2002 Nov 6;531(2):132-6
12417300
J Cell Biol. 1979 Dec;83(3):576-87
574870
Biochem J. 2006 Mar 15;394(Pt 3):527-43
16492141
J Clin Invest. 1997 Apr 15;99(8):1991-8
9109444
Biochem Biophys Res Commun. 2008 Oct 3;374(4):679-82
18675253
Mol Biol Cell. 2005 Nov;16(11):5247-57
16135529
J Biol Chem. 1998 Apr 10;273(15):9188-96
9535909
Nat Clin Pract Cardiovasc Med. 2008 May;5(5):258-67
18382419
Q Rev Biophys. 2001 Aug;34(3):325-472
11838236
J Biol Chem. 1995 May 26;270(21):12751-61
7539006
J Biol Chem. 2001 Jan 19;276(3):1780-8
11035005
Circ Res. 1996 Oct;79(4):647-58
8831488
Exp Cell Res. 2002 Apr 15;275(1):67-80
11925106
J Biol Chem. 1999 Apr 9;274(15):10489-96
10187840
Heart Rhythm. 2007 Sep;4(9):1196-205
17765621
Circ Res. 2007 Dec 7;101(12):1283-91
17932323
J Membr Biol. 1995 Dec;148(3):243-53
8747556
Curr Biol. 2004 Apr 20;14(8):650-8
15084279
J Biol Chem. 2000 Aug 18;275(33):25207-15
10940315
Nature. 2009 Apr 2;458(7238):597-602
19340074
J Biol Chem. 2001 Jun 22;276(25):23051-5
11313345
Trends Cell Biol. 2006 Mar;16(3):159-66
16490353
J Biol Chem. 1997 Sep 5;272(36):22824-31
9278444
Heart Rhythm. 2008 Dec;5(12):1715-23
19084810
J Biol Chem. 2005 Mar 25;280(12):11458-66
15644317
Biochem Biophys Res Commun. 2007 Dec 14;364(2):313-7
17945186
Cell Commun Adhes. 2003 Jul-Dec;10(4-6):211-4
14681018
J Cell Biol. 2000 Jun 26;149(7):1503-12
10871288
Mol Biol Cell. 2007 Feb;18(2):337-47
17108328
Curr Biol. 1998 Jul 30-Aug 13;8(16):931-4
9707407
J Biol Chem. 1995 Nov 3;270(44):26399-403
7592854
Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12545-50
18719117
Eur J Cell Biol. 1999 Dec;78(12):856-66
10669104
Biochim Biophys Acta. 2005 Jun 10;1711(2):154-63
15955300
J Cell Biol. 1998 Mar 9;140(5):1199-209
9490732
N Engl J Med. 2009 Mar 12;360(11):1075-84
19279339
Biol Chem. 2006 Sep;387(9):1227-36
16972791
Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10446-51
12149451
Biochemistry. 2005 Feb 22;44(7):2385-96
15709751
Protein Sci. 2006 Oct;15(10):2344-55
17008717
Circ Res. 2001 Feb 16;88(3):333-9
11179202
J Membr Biol. 2007 Aug;218(1-3):65-71
17585361
Nat Rev Mol Cell Biol. 2003 Apr;4(4):285-94
12671651
J Biol Chem. 2003 Mar 7;278(10):8326-32
12506110
Mol Biol Cell. 2005 Dec;16(12):5686-98
16195341
Circ Res. 2009 May 8;104(9):1103-12
19342602
Circ Res. 2007 Sep 28;101(7):703-11
17673670
Cell. 1993 Sep 24;74(6):1065-77
7691412