Validation of the association between AGTRL1 polymorphism and coronary artery disease in the Japanese and Korean populations.
Coronary artery disease (CAD) and stroke are the major health problems in many countries because of their increasing prevalence and high mortality. It is well known that CAD and stroke are based on atherosclerosis and shared environmental and genetic risk factors. Recently, an association of a functional sequence variation -154G>A in the angiotensin receptor-like 1 (AGTRL1) with a susceptibility to stroke was reported. In this study, we investigated a total of 1479 CAD cases and 2062 controls from the Japanese and Korean populations to validate the association of AGTRL1 with CAD. However, we obtained no evidence of the association in both the Japanese (odds ratio (OR)=0.95, 95% confidence interval (CI); 0.82-1.10, P=0.47, allele count model) and Korean (OR=0.90, 95% CI; 0.77-1.05, P=0.18, allele count model) populations. In addition, there was no trend of association between the risk allele and severity of coronary atherosclerosis. These data suggested that AGTRL1 did not contribute much to the atherosclerosis of the coronary artery.
Hinohara
Kunihiko
K
Department of Molecular Pathogenesis, Medical Research Institute, and Laboratory of Genome Diversity, Graduate School of Biomedical Science, Tokyo Medical and Dental University, Tokyo, Japan.
Nakajima
Toshiaki
T
Sasaoka
Taishi
T
Sawabe
Motoji
M
Lee
Bok-Soo
BS
Ban
Ji-Min
JM
Park
Jeong-Euy
JE
Izumi
Toru
T
Kimura
Akinori
A
D000368:Aged; D000075244:Apelin Receptors; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000235:genetics*; D005260:Female; D006801:Humans; D007723:Korea; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D043562:Receptors, G-Protein-Coupled / Q000235:genetics*
C104575:APLNR protein, human; D000075244:Apelin Receptors; D043562:Receptors, G-Protein-Coupled