Vaccination as a triggering event for autoimmune hepatitis.
The pathogenesis of autoimmune hepatitis entails complex interactions between triggering factors, autoantigens, genetic predisposition, and immunoregulatory networks. Implicated triggering factors are numerous and include toxins, medications, and infectious agents. In this article, we present a unique case of a 31-year-old woman with severe autoimmune hepatitis apparently abruptly triggered by vaccination. All evidence suggests this was an idiosyncratic response to either hepatitis A or yellow fever vaccination.
Perumalswami
Ponni
P
Division of Liver Diseases, Department of Medicine, The Mount Sinai Medical Center, New York, New York 10029, USA.
Peng
Lan
L
Odin
Joseph A
JA
D000328:Adult; D015415:Biomarkers / Q000097:blood; D001707:Biopsy, Needle; D004359:Drug Therapy, Combination; D005260:Female; D022362:Hepatitis A Vaccines / Q000009:adverse effects*; D019693:Hepatitis, Autoimmune / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008099:Liver / Q000473:pathology; D016896:Treatment Outcome; D022341:Yellow Fever Vaccine / Q000009:adverse effects*
D015415:Biomarkers; D022362:Hepatitis A Vaccines; D007166:Immunosuppressive Agents; D022341:Yellow Fever Vaccine