title: Metabolites from the sea hare Aplysia fasciata.
abstract: Examination of the digestive and hermaphroditic glands' organic extract of the sea hare Aplysia fasciata yielded 16 metabolites, including eight sesquiterpenes, three diterpenes, and five C(15)-acetogenins. Among them, three sesquiterpenes, 6-hydroxy-1-brasilene (1), epibrasilenol acetate (2), and 6-epi-beta-snyderol (3), one acetogenin, (3Z,9Z)-7-chloro-6-hydroxy-12-oxo-pentadeca-3,9-dien-1-yne (4), and one diterpene, 16-acetoxy-15-bromo-7-hydroxy-9(11)-parguerene (5), are new natural products. The structure elucidation and the assignment of the relative configurations of the isolated natural products were established on the basis of extensive analyses of their spectroscopic data (NMR, MS, IR).
authors.affiliation: Department of Pharmacognosy and Chemistry of Natural Products, School of Pharmacy, University of Athens, Panepistimiopolis Zografou, Athens, Greece.
authors.forename: Efstathia
authors.initials: E
authors.lastname: Ioannou
authors.forename: Michela
authors.initials: M
authors.lastname: Nappo
authors.forename: Conxita
authors.initials: C
authors.lastname: Avila
authors.forename: Constantinos
authors.initials: C
authors.lastname: Vagias
authors.forename: Vassilios
authors.initials: V
authors.lastname: Roussis
mesh_terms: D000818:Animals; D001048:Aplysia / Q000737:chemistry* / Q000378:metabolism; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification*; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009792:Oceans and Seas; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D004224:Diterpenes; D012717:Sesquiterpenes