Pattern separation and completion in olfaction.
The nervous system must provide a mechanism for very precise discrimination of differing patterns of activity, yet at the same time, there must be a mechanism for generalization to prevent all experiences from being independent and novel. Pattern separation and completion by cortical circuits contribute to these processes, respectively. Based on theoretical and computational models of the piriform cortex and experimental designs developed for hippocampal spatial memory, we provide evidence for pattern separation and completion in the olfactory system and demonstrate the predictive power of these two processes for behavioral odor perception.
Wilson
Donald A
DA
Emotional Brain Institute, Nathan Kline Institute for Psychiatric Research, and Child and Adolescent Psychiatry, New York University School of Medicine, Orangeburg, New York 10962, USA. dwilson@nki.rfmh.org
D000818:Animals; D006624:Hippocampus / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D009812:Odorants; D009830:Olfactory Bulb / Q000502:physiology; D012903:Smell / Q000502:physiology*
J Neurosci. 2006 Jan 25;26(4):1247-59
16436612
Science. 1999 Oct 22;286(5440):711-5
10531048
Physiol Behav. 2001 Jan;72(1-2):51-63
11239981
Chem Senses. 2001 Jun;26(5):551-76
11418502
Science. 1999 Oct 22;286(5440):723-8
10531051
Neuron. 2001 Nov 20;32(4):723-35
11719211
Cold Spring Harb Symp Quant Biol. 1990;55:599-610
2132840
Behav Neurosci. 2006 Dec;120(6):1337-45
17201479
J Neurosci. 2000 Sep 15;20(18):6974-82
10995842
Neuron. 2004 Nov 18;44(4):581-4
15541306
J Neurophysiol. 1994 Aug;72(2):659-77
7527075
Proc Natl Acad Sci U S A. 1991 Aug 1;88(15):6462-6
1862075
Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):1953-8
17261800
Hippocampus. 1996;6(6):654-65
9034852
J Comp Neurol. 2000 Jul 10;422(4):496-509
10861522
Behav Neurosci. 2000 Feb;114(1):32-41
10718260
Neuron. 2006 Jun 15;50(6):937-49
16772174
Neuron. 1999 Jul;23(3):499-511
10433262
Chem Senses. 2001 Jun;26(5):585-94
11418504
J Neurosci. 2007 Sep 12;27(37):10015-23
17855616
Science. 2004 Aug 27;305(5688):1295-8
15272123
Learn Mem. 2001 Sep-Oct;8(5):279-85
11584075
Neuron. 2006 Feb 2;49(3):357-63
16446140
Philos Trans R Soc Lond B Biol Sci. 1971 Jul 1;262(841):23-81
4399412
Science. 2007 Jul 6;317(5834):94-9
17556551
Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3329-33
8475076
J Agric Food Chem. 2003 Feb 26;51(5):1377-81
12590484
Nat Neurosci. 2008 Dec;11(12):1378-80
18978781
J Neurosci. 2002 Jan 15;22(2):RC201
11784813
Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12506-11
10535952
Curr Opin Neurobiol. 1991 Aug;1(2):209-14
1821183
Brain Res. 1990 Aug 13;525(1):175-9
1978790
J Neurosci. 2004 Jul 21;24(29):6611-20
15269273
Science. 2007 Feb 16;315(5814):961-6
17303747
Science. 2008 Mar 21;319(5870):1640-2
18356518