title: Mesotocin and nonapeptide receptors promote estrildid flocking behavior.
abstract: Proximate neural mechanisms that influence preferences for groups of a given size are almost wholly unknown. In the highly gregarious zebra finch (Estrildidae: Taeniopygia guttata), blockade of nonapeptide receptors by an oxytocin (OT) antagonist significantly reduced time spent with large groups and familiar social partners independent of time spent in social contact. Opposing effects were produced by central infusions of mesotocin (MT, avian homolog of OT). Most drug effects appeared to be female-specific. Across five estrildid finch species, species-typical group size correlates with nonapeptide receptor distributions in the lateral septum, and sociality in female zebra finches was reduced by OT antagonist infusions into the septum but not a control area. We propose that titration of sociality by MT represents a phylogenetically deep framework for the evolution of OT's female-specific roles in pair bonding and maternal functions.
authors.affiliation: Department of Biology, Indiana University, Bloomington, IN 47405, USA. jlgoodso@indiana.edu
authors.forename: James L
authors.initials: JL
authors.lastname: Goodson
authors.forename: Sara E
authors.initials: SE
authors.lastname: Schrock
authors.forename: James D
authors.initials: JD
authors.lastname: Klatt
authors.forename: David
authors.initials: D
authors.lastname: Kabelik
authors.forename: Marcy A
authors.initials: MA
authors.lastname: Kingsbury
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001665:Binding Sites; D005260:Female; D046369:Finches / Q000502:physiology*; D008297:Male; D009951:Ornipressin / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology; D010121:Oxytocin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000502:physiology; D016548:Prosencephalon / Q000378:metabolism; D018013:Receptors, Neuropeptide / Q000037:antagonists & inhibitors / Q000378:metabolism*; D018045:Receptors, Oxytocin / Q000037:antagonists & inhibitors / Q000378:metabolism; D020665:Septum of Brain / Q000378:metabolism*; D012727:Sex Characteristics; D012919:Social Behavior; D013045:Species Specificity; D014668:Vasotocin / Q000008:administration & dosage / Q000494:pharmacology
chemical_list: D018013:Receptors, Neuropeptide; D018045:Receptors, Oxytocin; C074541:vasotocin, desGly(NH2)(9)d(CH2)5-Tyr(Me)(2)-Thr(4)-Orn(8)-; D009951:Ornipressin; C001713:mesotocin; D010121:Oxytocin; D014668:Vasotocin
references.citation: Prog Brain Res. 2008;170:331-6
references.pmid: 18655893
references.citation: Behav Neurosci. 2004 Jun;118(3):620-6
references.pmid: 15174940
references.citation: Proc Natl Acad Sci U S A. 2006 Nov 7;103(45):17013-7
references.pmid: 17071744
references.citation: Philos Trans R Soc Lond B Biol Sci. 2007 Apr 29;362(1480):539-59
references.pmid: 17363359
references.citation: J Neurosci. 2005 Dec 7;25(49):11489-93
references.pmid: 16339042
references.citation: Nature. 2000 Feb 17;403(6771):769-72
references.pmid: 10693805
references.citation: Horm Behav. 2006 Nov;50(4):506-17
references.pmid: 16890230
references.citation: Horm Behav. 2006 Aug;50(2):223-36
references.pmid: 16643915
references.citation: Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4670-5
references.pmid: 17360582
references.citation: J Neurosci. 2009 Feb 4;29(5):1312-8
references.pmid: 19193878
references.citation: Adv Exp Med Biol. 1995;395:615-27
references.pmid: 8714026
references.citation: Horm Behav. 2004 Feb;45(2):136-43
references.pmid: 15019801
references.citation: Brain Res. 1983 Aug 29;273(2):307-17
references.pmid: 6311351
references.citation: J Neurosci. 2005 Jul 20;25(29):6807-15
references.pmid: 16033890
references.citation: J Comp Neurol. 2009 Mar 10;513(2):197-208
references.pmid: 19132730
references.citation: Comp Biochem Physiol B Biochem Mol Biol. 2006 Jan;143(1):12-9
references.pmid: 16311051
references.citation: Horm Behav. 2000 Feb;37(1):49-56
references.pmid: 10712858
references.citation: Front Neuroendocrinol. 2004 Sep-Dec;25(3-4):150-76
references.pmid: 15589267
references.citation: Prog Brain Res. 2008;170:261-76
references.pmid: 18655888
references.citation: Science. 2008 Nov 7;322(5903):900-4
references.pmid: 18988842
references.citation: Prog Brain Res. 2008;170:3-15
references.pmid: 18655867
references.citation: Behav Neurosci. 1995 Aug;109(4):782-9
references.pmid: 7576222
references.citation: Neuron. 2008 May 22;58(4):639-50
references.pmid: 18498743
references.citation: J Neurosci. 2001 Oct 15;21(20):8278-85
references.pmid: 11588199
references.citation: Curr Opin Pharmacol. 2008 Dec;8(6):731-4
references.pmid: 18656552