title: A score test for assessing the cured proportion in the long-term survivor mixture model.
abstract: The long-term survivor mixture model is commonly applied to analyse survival data when some individuals may never experience the failure event of interest. A score test is presented to assess whether the cured proportion is significant to justify the long-term survivor mixture model. Sampling distribution and power of the test statistic are evaluated by simulation studies. The results confirm that the proposed test statistic performs well in finite sample situations. The test procedure is illustrated using a breast cancer survival data set and the clustered multivariate failure times from a multi-centre clinical trial of carcinoma.
authors.affiliation: School of Public Health, Curtin Health Innovation Research Institute, Curtin University of Technology, GPO Box U 1987, Perth, WA 6845, Australia.
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhao
authors.forename: Andy H
authors.initials: AH
authors.lastname: Lee
authors.forename: Kelvin K W
authors.initials: KK
authors.lastname: Yau
authors.forename: Valerie
authors.initials: V
authors.lastname: Burke
authors.forename: Geoffrey J
authors.initials: GJ
authors.lastname: McLachlan
mesh_terms: D001943:Breast Neoplasms / Q000401:mortality; D003198:Computer Simulation; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D037102:Lectins / Q000737:chemistry; D008954:Models, Biological; D015233:Models, Statistical; D017741:Survivors
chemical_list: D037102:Lectins
references.citation: Stat Med. 2007 Mar 30;26(7):1608-22
references.pmid: 16794991
references.citation: Stat Med. 2004 Sep 15;23(17):2729-44
references.pmid: 15316955
references.citation: Lancet. 1987 May 9;1(8541):1054-6
references.pmid: 2883395
references.citation: Biometrics. 2000 Mar;56(1):227-36
references.pmid: 10783800
references.citation: Biometrics. 2000 Mar;56(1):237-43
references.pmid: 10783801
references.citation: Stat Med. 2006 May 30;25(10):1660-71
references.pmid: 16143993
references.citation: Stat Med. 2001 Jun 15;20(11):1591-607
references.pmid: 11391690