title: Dynamic dual-tracer PET reconstruction.
abstract: Although of important medical implications, simultaneous dual-tracer positron emission tomography reconstruction remains a challenging problem, primarily because the photon measurements from dual tracers are overlapped. In this paper, we propose a simultaneous dynamic dual-tracer reconstruction of tissue activity maps based on guidance from tracer kinetics. The dual-tracer reconstruction problem is formulated in a state-space representation, where parallel compartment models serve as continuous-time system equation describing the tracer kinetic processes of dual tracers, and the imaging data is expressed as discrete sampling of the system states in measurement equation. The image reconstruction problem has therefore become a state estimation problem in a continuous-discrete hybrid paradigm, and H infinity filtering is adopted as the estimation strategy. As H infinity filtering makes no assumptions on the system and measurement statistics, robust reconstruction results can be obtained for the dual-tracer PET imaging system where the statistical properties of measurement data and system uncertainty are not available a priori, even when there are disturbances in the kinetic parameters. Experimental results on digital phantoms, Monte Carlo simulations and physical phantoms have demonstrated the superior performance.
authors.affiliation: State Key Laboratory of Modern Optical Instrumentation, Zhejiang University, HangZhou, Zhejiang, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Gao
authors.forename: Huafeng
authors.initials: H
authors.lastname: Liu
authors.forename: Yiqiang
authors.initials: Y
authors.lastname: Jian
authors.forename: Pengcheng
authors.initials: P
authors.lastname: Shi
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008954:Models, Biological; D019047:Phantoms, Imaging; D049268:Positron-Emission Tomography / Q000379:methods*; D011865:Radioisotope Dilution Technique; D011868:Radioisotopes / Q000008:administration & dosage*; D019275:Radiopharmaceuticals / Q000008:administration & dosage; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D011868:Radioisotopes; D019275:Radiopharmaceuticals