title: Complete remission in a patient with human herpes virus-8 negative multicentric Castleman disease using CHOP chemotherapy.
abstract: Multicentric Castleman disease (MCD) is a rare lymphoproliferative disorder. Although MCD pathogenesis is unclear, studies have suggested that human herpesvirus 8 (HHV-8) may be associated with the disorder. Recent reports have identified MCD cases without viral infection. A 43-year-old woman presented to our hospital for fever and myalgia of 6 months' duration. The complete blood count revealed an elevated leukocyte count (15.1x10(3)/microL) and a decreased hemoglobin level of 10.0 g/dL. The C-reactive protein level was elevated at 276.5 mg/L. Thoracic computed tomography (CT) scans revealed bilateral axillary lymphadenopathy. There was no evidence of HHV-8, human immunodeficiency virus (HIV), or Mycobacterium infection. Histologic evaluation of a lymph node biopsy from the left axilla yielded a diagnosis of MCD. Cyclophosphamide, adriamycin, vincristine, and prednisone (CHOP) were administered for a total of 4 cycles. The patient's fever and lymphadenopathy resolved after the course of chemotherapy. She has been in complete remission for 24 months at this writing. As previously reported, this case report suggests that MCD can develop without viral infection. CHOP chemotherapy may be an effective treatment option for newly diagnosed MCD patients.
authors.affiliation: Division of Oncology and Hematology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
authors.forename: Hee Yeon
authors.initials: HY
authors.lastname: Seo
authors.forename: Eui Bae
authors.initials: EB
authors.lastname: Kim
authors.forename: Jee Won
authors.initials: JW
authors.lastname: Kim
authors.forename: Bong Kyoung
authors.initials: BK
authors.lastname: Shin
authors.forename: Seok Jin
authors.initials: SJ
authors.lastname: Kim
authors.forename: Byung Soo
authors.initials: BS
authors.lastname: Kim
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