Proinflammatory cytokine effects on mesenchymal stem cell therapy for the ischemic heart.
Mesenchymal stem cells (MSCs) hold great promise for improving myocardial recovery after ischemia. The cardiothoracic surgeon is uniquely positioned to be at the forefront of any clinical application of this therapy. As such, a basic understanding of stem cells and the cytokines that affect stem cell function will be an essential component of the surgeon's ever-expanding knowledge base. This review provides: (1) a general overview of stem cells and MSCs in particular, (2) critically analyzes several cytokines known to alter MSC function, and (3) discusses methods to manipulate cytokine-activated MSCs to improve MSC function for potential clinical application.
Abarbanell
Aaron M
AM
Clarian Cardiovascular Surgery, Methodist Hospital, Indianapolis, Indiana, USA.
Coffey
Arthur C
AC
Fehrenbacher
John W
JW
Beckman
Daniel J
DJ
Herrmann
Jeremy L
JL
Weil
Brent
B
Meldrum
Daniel R
DR
D000818:Animals; D016207:Cytokines / Q000097:blood*; D006082:Graft Enhancement, Immunologic / Q000379:methods; D024002:HMGB Proteins / Q000097:blood; D017228:Hepatocyte Growth Factor / Q000097:blood; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D045164:Mesenchymal Stem Cell Transplantation; D017202:Myocardial Ischemia / Q000276:immunology* / Q000601:surgery*; D019899:Paracrine Communication / Q000276:immunology; D053773:Transforming Growth Factor beta1 / Q000097:blood; D014181:Transplantation Immunology / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D016207:Cytokines; D024002:HMGB Proteins; D018836:Inflammation Mediators; D053773:Transforming Growth Factor beta1; D014409:Tumor Necrosis Factor-alpha; D017228:Hepatocyte Growth Factor; D007334:Insulin-Like Growth Factor I