Ancestry informative markers and admixture proportions in northeastern Mexico.
To investigate the ancestral admixture in the Mestizo population in northeastern Mexico, we genotyped 74 ancestral informative markers (AIMs) and 15 Y-single-nucleotide polymorphisms (Y-SNPs) in 100 individuals. The Native American contribution is 56% (range: 27.4-81.2%), the European contribution is 38% (range: 16.7-70.5%) and the West African contribution is 6%. The results show a higher European contribution than was reported in other similar studies in the country, albeit with a predominant Native American ancestry. No remarkable differences in the ancestry proportions were observed using subgroups of 74, 54, 34 and 24 AIMs. The paternal lineage calculated by genotyping of 15 Y-SNPs, shows a major component of European and Eurasian ancestry markers ( approximately 78%), compared with Amerindian ( approximately 12%) and African markers (10%). This information will set a reference for future determinations of admixture proportions in the Mestizo population from Mexico and for population-based association studies of complex diseases.
Martinez-Fierro
Margarita L
ML
Department of Biochemistry and Molecular Medicine, School of Medicine, Universidad Autonoma de Nuevo Leon, Monterrey, Mexico.
Beuten
Joke
J
Leach
Robin J
RJ
Parra
Esteban J
EJ
Cruz-Lopez
Miguel
M
Rangel-Villalobos
Hector
H
Riego-Ruiz
Lina R
LR
Ortiz-Lopez
Rocio
R
Martinez-Rodriguez
Herminia G
HG
Rojas-Martinez
Augusto
A
D044383:Black People / Q000235:genetics*; D041322:Chromosomes, Human, Y / Q000235:genetics*; D004247:DNA / Q000235:genetics*; D005828:Genetics, Population; D006801:Humans; D007198:Indians, North American / Q000235:genetics*; D008297:Male; D008800:Mexico; D010802:Phylogeny; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D044465:White People / Q000235:genetics*
D004247:DNA