title: ent-Kaurane and cembrane diterpenoids from Isodon sculponeatus and their cytotoxicity.
abstract: Nine new ent-kauranoids, sculponins D-L (1-9), and 14 known diterpenoids (10-23) were isolated from the aerial parts of Isodon sculponeatus. The structures of the new diterpenoids were determined by detailed interpretation of their 1D and 2D NMR spectra and HRESIMS. The isolated compounds were evaluated for their cytotoxic activities against a small panel of human cancer cell lines.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
authors.forename: Li-Mei
authors.initials: LM
authors.lastname: Li
authors.forename: Guo-You
authors.initials: GY
authors.lastname: Li
authors.forename: Jian-Xin
authors.initials: JX
authors.lastname: Pu
authors.forename: Wei-Lie
authors.initials: WL
authors.lastname: Xiao
authors.forename: Li-Sheng
authors.initials: LS
authors.lastname: Ding
authors.forename: Han-Dong
authors.initials: HD
authors.lastname: Sun
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D045786:Diterpenes, Kaurane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D037602:Isodon / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D045786:Diterpenes, Kaurane; D004365:Drugs, Chinese Herbal