title: Cerecyte versus platinum coils in the treatment of intracranial aneurysms: packing attenuation and clinical and angiographic midterm results.
abstract: OBJECTIVE
  As modifications are made to coils, monitoring the safety profile, ability to achieve high packing attenuation, and durability of occlusion as compared to the standard bare platinum coils is of paramount importance. We compared packing attenuation, initial occlusion, and recanalization rates between Cerecyte and bare platinum coils in the treatment of ruptured and unruptured cerebral aneurysms.
  
  
  METHODS
  We compared 63 patients (67 aneurysms) treated with Cerecyte coils with 65 patients (70 aneurysms) treated by using bare platinum coils. Results were classified by the Raymond score. Clinical outcomes were assessed by using a modified Rankin Scale. Angiographic and clinical follow-ups were performed routinely at 6 and 12 months after the intervention.
  
  
  RESULTS
  In the Cerecyte group, complete occlusion of the aneurysm (grade 1) was accomplished in 49% (33/67), a small residual neck (grade 2) was seen in 21% (14/67), and dome filling (grade 3) was seen in 30% (20/67). In the platinum group, 41% (29/70) were grade 1, 39% (27/70) were grade 2, and 20% (14/70) were grade 3 immediately postembolization. Mean packing attenuation was 43 +/- 28% in the Cerecyte group and 40 +/- 23% in the bare platinum group (P = .68). Twelve-month follow-up data were available for 54% (36/67) of the Cerecyte population and 43% (30/70) of the bare platinum population. There were 5 cases of neck recanalization (11%) in the Cerecyte group and 11 cases (23%) in the bare platinum group (P = .17). No rebleeds were noted in the follow-up period.
  
  
  CONCLUSIONS
  Cerecyte coils have a satisfactory safety profile. We were able to achieve high packing attenuations and initial occlusion rates similar to those obtainable with platinum coils.
authors.affiliation: Baptist Cardiac and Vascular Institute, Miami, FL, USA.
authors.forename: I
authors.initials: I
authors.lastname: Linfante
authors.forename: M J
authors.initials: MJ
authors.lastname: DeLeo
authors.forename: M J
authors.initials: MJ
authors.lastname: Gounis
authors.forename: C S
authors.initials: CS
authors.lastname: Brooks
authors.forename: A K
authors.initials: AK
authors.lastname: Wakhloo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000792:Angiography; D004621:Embolization, Therapeutic / Q000295:instrumentation* / Q000379:methods*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D010984:Platinum; D016896:Treatment Outcome
chemical_list: D010984:Platinum
references.citation: J Neurosurg. 1999 Aug;91(2):284-93
references.pmid: 10433317
references.citation: Stroke. 2007 Oct;38(10):2855-7
references.pmid: 17717311
references.citation: Neurosurgery. 2008 Apr;62(4):799-805; discussion 805-6
references.pmid: 18496185
references.citation: AJNR Am J Neuroradiol. 2005 Aug;26(7):1723-31
references.pmid: 16091521
references.citation: AJNR Am J Neuroradiol. 2006 Feb;27(2):289-92
references.pmid: 16484394
references.citation: AJNR Am J Neuroradiol. 2002 May;23(5):762-7
references.pmid: 12006273
references.citation: Neurosurgery. 1997 Jun;40(6):1233-43; discussion 1243-4
references.pmid: 9179897
references.citation: Lancet. 2005 Sep 3-9;366(9488):809-17
references.pmid: 16139655
references.citation: AJNR Am J Neuroradiol. 2004 Apr;25(4):577-83
references.pmid: 15090345
references.citation: J Neurosurg. 1997 Jan;86(1):109-12
references.pmid: 8988088
references.citation: Stroke. 2005 Sep;36(9):1948-53
references.pmid: 16051893
references.citation: Radiology. 2003 Jun;227(3):720-4
references.pmid: 12773678
references.citation: Radiology. 1998 May;207(2):519-23
references.pmid: 9577504
references.citation: AJNR Am J Neuroradiol. 2003 Aug;24(7):1446-8
references.pmid: 12917143
references.citation: J Neurosurg. 2003 May;98(5):959-66
references.pmid: 12744354
references.citation: Stroke. 2002 Jan;33(1):210-7
references.pmid: 11779912
references.citation: AJNR Am J Neuroradiol. 2007 Aug;28(7):1395-400
references.pmid: 17698550
references.citation: Neurosurgery. 2006 Jan;58(1):51-9; discussion 51-9
references.pmid: 16385329
references.citation: Stroke. 2003 Jun;34(6):1398-403
references.pmid: 12775880
references.citation: Stroke. 2006 Apr;37(4):1028-32
references.pmid: 16514098
references.citation: Stroke. 2001 Mar;32(3):597-605
references.pmid: 11239174
references.citation: Stroke. 2006 Jun;37(6):1443-50
references.pmid: 16675742
references.citation: AJNR Am J Neuroradiol. 2001 Aug;22(7):1410-7
references.pmid: 11498439
references.citation: Lancet. 2002 Oct 26;360(9342):1267-74
references.pmid: 12414200
references.citation: AJNR Am J Neuroradiol. 1999 Apr;20(4):549-52
references.pmid: 10319957
references.citation: AJNR Am J Neuroradiol. 2008 Jan;29(1):53-6
references.pmid: 17921230
references.citation: Stroke. 2003 Aug;34(8):2031-7
references.pmid: 12869719
references.citation: AJNR Am J Neuroradiol. 2001 Feb;22(2):323-33
references.pmid: 11156778
references.citation: AJNR Am J Neuroradiol. 2006 Nov-Dec;27(10):2053-7
references.pmid: 17110665