The cell-based model of coagulation.
OBJECTIVE
To review the current model describing coagulation processes, including the critical contributions of cells.


METHODS
Original research articles, scientific reviews, and textbooks.


RESULTS
Normal hemostasis is vital for prevention of blood loss, but controls are necessary to limit coagulation to the site of injury. The previous cascade model of blood coagulation, although refined and updated over the last few decades, is flawed as a description of how hemostasis occurs in vivo. The recently proposed model incorporates the vital role of cells in coagulation processes, and corrects deficiencies of the older cascade models.


CONCLUSIONS
The cell-based model of coagulation provides a description of coagulation that more likely reflects hemostatic processes as they occur in vivo.
Smith
Stephanie A
SA
Department of Internal Medicine, University of Illinois at Urbana-Champaign, Urbana, IL, USA. sasmith6@illinois.edu
D000818:Animals; D001777:Blood Coagulation / Q000502:physiology*; D001779:Blood Coagulation Factors / Q000378:metabolism; D006801:Humans; D008954:Models, Biological
D001779:Blood Coagulation Factors