The role of PTEN-induced kinase 1 in mitochondrial dysfunction and dynamics.
Mutations in parkin, PTEN-induced kinase 1 (PINK1) and DJ-1 can all cause autosomal recessive forms of Parkinson's disease. Recent data suggest that these recessive parkinsonism-associated genes converge within a single pathogenic pathway whose dysfunction leads to the loss of substantia nigra pars compacta neurons. The major common functional effects of all three genes relate to mitochondrial and oxidative damage, with a possible additional involvement of the ubiquitin proteasome system. This review highlights the role of the mitochondrial kinase, PINK1, in protection against mitochondrial dysfunction and how this might relate to loss of substantia nigra neurons in recessive parkinsonism.
Thomas
Kelly Jean
KJ
Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD 20892, USA.
Cookson
Mark R
MR
D000818:Animals; D006801:Humans; D008928:Mitochondria / Q000378:metabolism* / Q000473:pathology*; D008954:Models, Biological; D018384:Oxidative Stress / Q000235:genetics / Q000502:physiology; D020734:Parkinsonian Disorders / Q000201:enzymology / Q000503:physiopathology; D011494:Protein Kinases / Q000235:genetics / Q000378:metabolism*; D000099202:PTEN-Induced Putative Kinase
D011494:Protein Kinases; D000099202:PTEN-Induced Putative Kinase
Ann Neurol. 2006 Oct;60(4):414-9
16969854
FEBS Lett. 2002 Jul 17;523(1-3):171-6
12123827
Curr Biol. 2005 Apr 12;15(7):678-83
15823542
Neurobiol Aging. 2006 Apr;27(4):524-9
16213628
J Biol Chem. 2005 Jul 15;280(28):26185-92
15899901
J Neurochem. 2008 Jul;106(1):464-74
18397367
Nat Genet. 2006 May;38(5):515-7
16604074
Nat Rev Neurosci. 2008 Nov;9(11):826-38
18931696
J Neurochem. 2008 Jun;105(5):1806-19
18248624
J Cell Sci. 2004 Mar 1;117(Pt 7):1201-10
14996942
Neurology. 2000 Aug 22;55(4):533-8
10953187
Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14503-8
18799731
Proteomics. 2007 Jun;7(13):2189-200
17533645
Hum Genet. 2001 Dec;109(6):584-91
11810270
Hum Mol Genet. 2008 Feb 15;17(4):602-16
18003639
Proc Natl Acad Sci U S A. 2006 Jul 11;103(28):10793-8
16818890
Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):2696-701
8610103
Nature. 1995 Jul 27;376(6538):313-20
7630397
Biochem Biophys Res Commun. 2003 Jan 10;300(2):482-93
12504110
J Struct Biol. 2004 Sep;147(3):259-67
15450295
Hum Mol Genet. 2006 Mar 15;15(6):883-95
16449237
Neurology. 2004 Oct 26;63(8):1486-8
15505171
EMBO J. 2008 Jan 23;27(2):433-46
18200046
Ann Neurol. 1998 Dec;44(6):873-81
9851431
Ann Neurol. 2004 Sep;56(3):427-31
15349871
J Cell Sci. 2005 Sep 15;118(Pt 18):4141-51
16118244
PLoS Biol. 2007 Jul;5(7):e172
17579517
J Cell Biol. 2007 Aug 27;178(5):749-55
17709429
Brain. 2006 Jul;129(Pt 7):1720-31
16702191
J Cell Biol. 2007 Aug 27;178(5):757-64
17709430
Curr Opin Chem Biol. 2004 Dec;8(6):610-6
15556404
J Cell Biol. 2006 Jun 5;173(5):645-50
16735578
Biochemistry. 2009 Mar 10;48(9):2045-52
19152501
J Neurochem. 1989 Feb;52(2):381-9
2911023
J Cell Biol. 2005 Sep 26;170(7):1021-7
16186251
J Biol Chem. 2003 Mar 7;278(10):7743-6
12509422
J Mol Biol. 2003 Nov 28;334(3):445-58
14623186
Mol Biol Cell. 2004 Nov;15(11):5001-11
15356267
Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2653-8
16477035
Oncogene. 2001 Jul 27;20(33):4457-65
11494141
Ann Neurol. 1996 Oct;40(4):663-71
8871587
Neurosci Lett. 2008 Jan 3;430(1):13-7
18031932
J Cell Biol. 1998 Oct 19;143(2):333-49
9786946
PLoS One. 2008 Jun 18;3(6):e2455
18560593
J Cell Biol. 2003 Jan 20;160(2):189-200
12527753
J Cell Sci. 2002 Apr 15;115(Pt 8):1663-74
11950885
Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1638-43
18230723
Hum Mol Genet. 2005 Aug 1;14(15):2099-111
15961413
Ann Neurol. 1992 Jul;32(1):113-4
1642467
Cell. 2006 Oct 20;127(2):383-95
17055438
J Cell Biol. 2004 Sep 27;166(7):1027-39
15452144
Nat Genet. 2006 May;38(5):518-20
16604072
J Biochem. 2008 Apr;143(4):449-54
18174190
J Biol Chem. 2004 Aug 20;279(34):35967-74
15208300
Neurobiol Dis. 2007 Feb;25(2):401-11
17141510
Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):11664-8
8876193
Int J Biochem Cell Biol. 2005 Dec;37(12):2478-503
16103002
J Biol Chem. 2004 Apr 30;279(18):18792-8
14970223
Mol Cell Biol. 2003 Aug;23(15):5409-20
12861026
Dev Cell. 2007 May;12(5):793-806
17488629
Ann Neurol. 1989 Dec;26(6):719-23
2557792
Mov Disord. 2008 Apr 30;23(6):881-5
18307263
J Biol Chem. 2008 May 16;283(20):13501-5
18372247
Am J Physiol. 1997 Apr;272(4 Pt 1):C1286-94
9142854
Mol Biol Cell. 2001 Aug;12(8):2245-56
11514614
Hum Mol Genet. 2005 Nov 15;14(22):3477-92
16207731
Mol Cell Biochem. 2004 Jan-Feb;256-257(1-2):331-9
14977192
J Cell Sci. 2001 Mar;114(Pt 5):867-74
11181170
Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11364-9
18687901
Mov Disord. 2006 Jun;21(6):789-93
16482571
J Cell Biol. 2006 May 22;173(4):545-57
16717129
J Biol Chem. 2005 May 13;280(19):18598-603
15760898
Science. 2004 Sep 17;305(5691):1747-52
15297626
Mol Biol Cell. 2007 Aug;18(8):3105-18
17553932
Mov Disord. 1997 Jan;12(1):3-8
8990047
EMBO J. 2001 Dec 3;20(23):6627-36
11726499
Proc Natl Acad Sci U S A. 2007 Jul 10;104(28):11649-54
17606912
Neurosci Res. 2008 May;61(1):43-8
18359116
Ann Neurol. 1999 Dec;46(6):920-4
10589547
Lancet. 1989 Jun 3;1(8649):1269
2566813
Cancer Res. 2004 Feb 1;64(3):985-93
14871829
Cell. 2006 Jul 14;126(1):163-75
16839884
Nature. 2006 Jun 29;441(7097):1162-6
16672981
EMBO Rep. 2007 Oct;8(10):939-44
17721437
Toxicol Appl Pharmacol. 1996 Mar;137(1):34-41
8607139
Semin Cell Dev Biol. 1998 Aug;9(4):433-44
9813190
J Cell Biol. 2008 Dec 1;183(5):795-803
19029340
Proc Natl Acad Sci U S A. 1978 Aug;75(8):3863-6
80800
J Neurosci. 2003 Aug 27;23(21):7881-8
12944518
Nature. 2006 Jun 29;441(7097):1157-61
16672980
J Biol Chem. 2005 Apr 29;280(17):17154-62
15737990
Neurochem Res. 2008 Dec;33(12):2565-74
18473170
Exp Neurol. 2008 Aug;212(2):307-13
18511044
Hum Mol Genet. 2003 Mar 1;12(5):517-26
12588799
Proc Natl Acad Sci U S A. 2004 Nov 9;101(45):15927-32
15509649
Neurobiol Dis. 2007 Nov;28(2):216-26
17707122
EMBO J. 1998 May 1;17(9):2451-62
9564028
J Neurosci. 2007 Nov 7;27(45):12413-8
17989306
Brain Res. 2002 Mar 15;930(1-2):143-9
11879804
J Biol Chem. 2005 Oct 7;280(40):34025-32
16079129
Nat Struct Biol. 2001 Feb;8(2):176-83
11175909
Nature. 2006 May 25;441(7092):528-31
16648839
Dev Cell. 2007 May;12(5):807-16
17488630
J Biol Chem. 2007 Jul 27;282(30):21583-7
17553808
Development. 2004 May;131(9):2183-94
15073152
Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):12022-7
18687899
J Neurochem. 2007 Oct;103(1):303-11
17587308
J Biol Chem. 1991 Oct 15;266(29):19328-33
1655783
J Biol Chem. 2005 Apr 29;280(17):16619-24
15718234
J Cell Sci. 2004 Dec 15;117(Pt 26):6535-46
15572413
Ann Neurol. 1992 Dec;32(6):782-8
1471869
Ann Neurol. 2000 Nov;48(5):774-81
11079541
Annu Rev Genet. 2005;39:503-36
16285870
Science. 2004 Aug 6;305(5685):858-62
15297672
Hum Mutat. 2007 Jan;28(1):98
17154281
J Cell Biol. 1998 Oct 19;143(2):359-73
9786948
Biochem Biophys Res Commun. 2005 Dec 2;337(4):1133-8
16226715
J Cell Sci. 2007 Apr 1;120(Pt 7):1178-88
17341580
J Cell Biol. 2007 Jul 2;178(1):71-84
17606867
Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4078-83
12642658
Neuron. 2002 Dec 19;36(6):1063-77
12495622
Biophys J. 1999 Feb;76(2):725-34
9929477
Hum Mol Genet. 2006 Nov 1;15(21):3251-62
17000703
Dev Biol. 2007 Mar 1;303(1):108-20
17123504
Proteins. 2004 Jan 1;54(1):153-6
14705031
Mech Dev. 2002 Aug;116(1-2):213-6
12128227
J Neurosci Res. 2006 Nov 15;84(7):1543-54
16955485
Nat Rev Mol Cell Biol. 2004 Feb;5(2):133-47
15040446
J Cell Biol. 2007 May 7;177(3):439-50
17470634
Science. 2004 May 21;304(5674):1158-60
15087508
J Neurochem. 2006 Aug;98(3):951-61
16771836
Science. 1983 Feb 25;219(4587):979-80
6823561
Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1716-21
18218782
Ann Neurol. 2004 Sep;56(3):336-41
15349860
Biomed Khim. 2008 Jan-Feb;54(1):58-77
18421912
Cell. 1997 Jul 11;90(1):121-9
9230308
Hum Mol Genet. 2006 Jun 1;15(11):1816-25
16632486
Ann Neurol. 2000 Nov;48(5):737-44
11079537
Proc Natl Acad Sci U S A. 2007 Jul 3;104(27):11441-6
17563363
Brain Res. 1984 Feb 6;292(2):390-4
6607092
Proc Natl Acad Sci U S A. 2006 Sep 5;103(36):13520-5
16938835
Neurology. 2005 Jun 14;64(11):1955-7
15955953
Cell Death Differ. 2000 Feb;7(2):137-44
10713728
Proc Natl Acad Sci U S A. 2005 Apr 19;102(16):5703-8
15824318
J Biol Chem. 2007 Apr 13;282(15):11521-9
17301055
J Neurochem. 2006 Jul;98(1):156-69
16805805
Curr Biol. 2004 Feb 17;14(4):340-5
14972687
Annu Rev Biochem. 2007;76:751-80
17362197
J Biochem. 2003 Sep;134(3):333-44
14561718
Nat Rev Mol Cell Biol. 2005 Aug;6(8):657-63
16025099
J Biol Chem. 2000 Nov 17;275(46):35661-4
10973942
Antioxid Redox Signal. 2008 Aug;10(8):1313-42
18435594
Apoptosis. 2007 May;12(5):835-40
17136322
Neurosci Lett. 1992 Aug 17;142(2):128-30
1454205
J Cell Sci. 2004 Sep 1;117(Pt 19):4389-400
15304525
Nature. 2006 Oct 12;443(7112):658-62
17035996
Brain Res. 1986 Jun 18;376(1):117-24
3487376
Proc Natl Acad Sci U S A. 2008 May 13;105(19):7070-5
18443288
Mol Cell. 2006 Mar 17;21(6):761-73
16543146
Sci Am. 1997 Aug;277(2):40-7
9245840
Cancer Lett. 2003 Nov 25;201(2):195-201
14607334
Neurology. 2006 Apr 11;66(7):1129-30; author reply 1129-30
16606941
J Exp Med. 1999 Jan 18;189(2):381-94
9892620
Mov Disord. 2006 Jun;21(6):875-9
16547921
Traffic. 2007 May;8(5):500-11
17451553
Int J Biochem Cell Biol. 1995 Feb;27(2):97-108
7767791
Ann Neurol. 2008 Nov;64(5):555-65
19067348
PLoS Genet. 2008 Jan;4(1):e6
18193945
Brain Res. 2007 Dec 12;1184:10-6
17950257
Biochim Biophys Acta. 2006 May-Jun;1757(5-6):518-24
16829229
J Histochem Cytochem. 2000 Jan;48(1):45-56
10653585
Hum Mol Genet. 2003 Nov 15;12(22):2957-65
14519684
Clin Genet. 2005 Nov;68(5):468-70
16207217
J Neurosci. 2003 Apr 15;23(8):3316-24
12716939
J Biol Chem. 2006 Dec 8;281(49):37972-9
17003040
Acta Neurol Scand Suppl. 1989;126:47-54
2618593
Nat Cell Biol. 2007 Nov;9(11):1243-52
17906618
Nature. 2003 May 29;423(6939):537-41
12774122
Nat Neurosci. 2000 Dec;3(12):1301-6
11100151