title: Images-based suppression of unwanted global signals in resting-state functional connectivity studies.
abstract: Correlated fluctuations of low-frequency fMRI signal have been suggested to reflect functional connectivity among the involved regions. However, large-scale correlations are especially prone to spurious global modulations induced by coherent physiological noise. Cardiac and respiratory rhythms are the most offending component, and a tailored preprocessing is needed in order to reduce their impact. Several approaches have been proposed in the literature, generally based on the use of physiological recordings acquired during the functional scans, or on the extraction of the relevant information directly from the images. In this paper, the performances of the denoising approach based on general linear fitting of global signals of noninterest extracted from the functional scans were assessed. Results suggested that this approach is sufficiently accurate for the preprocessing of functional connectivity data.
authors.affiliation: MARBILab, Museo storico della fisica e Centro di studi e ricerche "Enrico Fermi" Roma, Italy. federico.giove@roma1.infn.it
authors.forename: Federico
authors.initials: F
authors.lastname: Giove
authors.forename: Tommaso
authors.initials: T
authors.lastname: Gili
authors.forename: Vittorio
authors.initials: V
authors.lastname: Iacovella
authors.forename: Emiliano
authors.initials: E
authors.lastname: Macaluso
authors.forename: Bruno
authors.initials: B
authors.lastname: Maraviglia
mesh_terms: D000465:Algorithms; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods*; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity