Association between hepatic lipase -514 C/T promoter polymorphism and myocardial infarction is modified by history of hypercholesterolemia and waist circumference.
OBJECTIVE
To examine whether the association between the -514 C/T polymorphism of the hepatic lipase gene and myocardial infarction (MI) is modified by history of hypercholesterolemia and increased waist circumference.


RESULTS
A total of 1940 pairs of nonfatal MI cases and population-based controls were genotyped. Multiple conditional logistic regression was used for data analyses. The -514T variant was not associated with MI in the whole population. However, among people with history of hypercholesterolemia the T allele increased MI risk for heterozygous and homozygous carriers, respectively [OR=1.25 (95%CI=0.92-1.70) and OR=1.59 (95%CI=1.09-2.32). In contrast, the T allele decreased MI risk among people with no history of hypercholesterolemia [OR=0.85 (95%CI=0.70-1.03) and OR=0.76 (95%CI=0.60-0.97)], p for interaction=0.004. Among subjects with normal waist circumference there was no association between the -514T allele and MI for heterozygous and homozygous carriers, respectively [OR=1.04 (95%CI=0.86-1.25) and OR=0.96 (95%CI=0.77-1.21)], while among subjects with waist circumference above the limits of the metabolic syndrome definition there was a protective association [OR=0.63 (95%CI=0.45-0.90) and OR=0.81 (95%CI=0.53-1.25) p for interaction=0.04].


CONCLUSIONS
The -514T allele is associated with MI in opposite directions depending on the background of the studied population. This could explain what seem like inconsistent results across studies.
Baylin
A
A
Department of Community Health, Warren Alpert Medical School, Brown University, Providence, RI 0203, USA. ana_baylin@brown.edu
Ruiz-Narvaez
E
E
Jensen
M K
MK
Rimm
E
E
Campos
H
H
D000368:Aged; D016022:Case-Control Studies; D003364:Costa Rica; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D006937:Hypercholesterolemia / Q000150:complications*; D016013:Likelihood Functions; D008049:Lipase / Q000235:genetics*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000201:enzymology / Q000235:genetics*; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D018570:Risk Assessment; D012307:Risk Factors; D055105:Waist Circumference
C504173:LIPC protein, human; D008049:Lipase
Am J Epidemiol. 2001 Dec 15;154(12):1126-35
11744518
J Am Coll Cardiol. 2003 Jun 4;41(11):1972-82
12798568
J Biochem Mol Biol. 2003 Mar 31;36(2):237-42
12689525
Clin Biochem. 2000 Jun;33(4):291-6
10936588
J Lipid Res. 2002 Sep;43(9):1352-62
12235167
Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4532-7
9114024
Am J Clin Nutr. 2005 Jun;81(6):1429-35
15941898
Eur J Clin Invest. 2007 Jun;37(6):472-7
17537154
Arterioscler Thromb Vasc Biol. 1999 Aug;19(8):1975-8
10446080
Curr Opin Lipidol. 2000 Jun;11(3):277-83
10882343
Diabetologia. 2006 Jul;49(7):1552-9
16570154
J Clin Invest. 1998 Mar 1;101(5):956-60
9486964
Arterioscler Thromb. 1991 Jul-Aug;11(4):1077-88
2065029
Clin Biochem. 2003 Sep;36(6):421-9
12951168
Am J Clin Nutr. 2002 Oct;76(4):750-7
12324287
Circulation. 2001 Dec 18;104(25):3057-62
11748100
Circulation. 2002 Oct 29;106(18):2315-21
12403660
J Lipid Res. 1987 Apr;28(4):371-80
3585172
J Cardiovasc Risk. 2002 Apr;9(2):105-13
12006918
Clin Genet. 2006 Aug;70(2):114-21
16879193
Am Heart J. 2005 Aug;150(2):243-50
16086925
Am J Med. 2007 Mar;120(3 Suppl 1):S3-S11
17320520
J Med Genet. 2005 Sep;42(9):720-4
16141008
Curr Opin Lipidol. 2006 Aug;17(4):399-403
16832163
Arterioscler Thromb Vasc Biol. 2004 Oct;24(10):1750-4
15284087
J Clin Endocrinol Metab. 2002 Oct;87(10):4766-70
12364471
Arterioscler Thromb Vasc Biol. 2003 May 1;23(5):853-8
12637336
Circulation. 2003 Apr 1;107(12):1586-91
12668490
Eur J Clin Invest. 2001 Jul;31(7):574-80
11454011
J Lipid Res. 2000 Jan;41(1):155-8
10627514
Arterioscler Thromb Vasc Biol. 1997 Nov;17(11):2837-42
9409263
Am J Epidemiol. 2003 Nov 1;158(9):836-43
14585761
J Lipid Res. 2003 Jul;44(7):1279-86
12639974
J Med Genet. 2004 Mar;41(3):e28
14985399
Int J Epidemiol. 2000 Jun;29(3):429-37
10869314