Zuclopenthixol, D(1)/D(2) antagonist, for treatment of chronic aggressive schizophrenia and psychotic oligophrenic patients.
An open label trial was conducted to study the efficacy of zuclopenthixol decanoate, a D(1)/D(2) antagonist, in the treatment of chronic (> 10 years) neuroleptic-resistant aggressive schizophrenia (n = 10) and psychotic oligophrenic patients (n = 6). A significant reduction was noted in the Brief Psychiatric Rating Scale score, especially in the clusters of hostility-suspiciousness and excitement. After many years of seclusion, ten of the 16 patients were transferred to an open psychiatric department and were allowed to visit their families.
Grinshpoon
A
A
Mental Health Service, Israel Ministry of Health and Israel Defence Forces, Israel.
Moskowitz
M
M
Valevski
A
A
Kreizman
A
A
Palei
L
L
Mar
M
M
Weizman
A
A