title: High therapy adherence but substantial limitations to daily activities amongst members of the Dutch inflammatory bowel disease patients' organization: a patient empowerment study.
abstract: BACKGROUND
  Adherence is important for successful treatment in inflammatory bowel disease (IBD) patients. Previous studies demonstrated high prevalence of non-adherence.
  
  
  OBJECTIVE
  To assess IBD-patients' perceptions of therapy adherence and disease-related functional status in members of the Dutch patients' association of Crohn's disease and ulcerative colitis (CCUVN).
  
  
  METHODS
  Inflammatory bowel disease-patients completed anonymously a survey at the website of the CCUVN. Statistical analysis was performed using principal component analysis, univariate and multivariate logistic regression.
  
  
  RESULTS
  The questionnaire was completed by 1067 patients [617 (58%) Crohn's disease (CD) and 450 (42%) ulcerative colitis (UC)]. Mean age was 43 years (s.d. 13.7); women (66%). Of 920 patients currently using medication, 797 (87%) were adherent. Of the patients using 5-ASA, 91% were adherent (527/582), vs. 96% using corticosteroids (316/330) and 97% (414/425) using immunosuppressives. CD patients (OR 1.54; 95% CI 1.05-2.27), patients with duration of disease <or=8 years (OR 2.25; 95% CI 1.49-3.39) were more adherent. Fifty percent of patients reported a low functional status and were limited in daily activities.
  
  
  CONCLUSIONS
  This population-based study shows high therapy adherence, but low functional status in Dutch CCUVN-related IBD-patients. The high adherence rate in this present study could be an effect of CCUVN membership.
authors.affiliation: Department of Gastroenterology and Hepatology, Erasmus MC, Rotterdam, The Netherlands. j.baars@erasmusmc.nl
authors.forename: J E
authors.initials: JE
authors.lastname: Baars
authors.forename: Z
authors.initials: Z
authors.lastname: Zelinkova
authors.forename: P B F
authors.initials: PB
authors.lastname: Mensink
authors.forename: T
authors.initials: T
authors.lastname: Markus
authors.forename: C W N
authors.initials: CW
authors.lastname: Looman
authors.forename: E J
authors.initials: EJ
authors.lastname: Kuipers
authors.forename: C J
authors.initials: CJ
authors.lastname: Van Der Woude
mesh_terms: D000203:Activities of Daily Living; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000328:Adult; D010131:Aminosalicylic Acid / Q000627:therapeutic use*; D003093:Colitis, Ulcerative / Q000188:drug therapy* / Q000453:epidemiology; D003424:Crohn Disease / Q000188:drug therapy* / Q000453:epidemiology; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D010349:Patient Compliance; D010817:Physician-Patient Relations
chemical_list: D000305:Adrenal Cortex Hormones; D007166:Immunosuppressive Agents; D010131:Aminosalicylic Acid