Challenging the rationale of routine vasopressor therapy for management of hypotension.
There is persuasive evidence, including the present report by Dubin and colleagues, of a dissociation between increases in arterial pressure produced by vasopressor agents and improvement in microvascular perfusion and delivery of vital substrates. Especially in settings of septic shock, the current routine administration of adrenergic vasopressor therapy therefore may fail to reverse the primary defect.
Weil
Max Harry
MH
Weil Institute of Critical Care Medicine, Rancho Mirage, CA 92270, USA. weilm@weiliccm.org
Tang
Wanchun
W
D001794:Blood Pressure / Q000187:drug effects; D006801:Humans; D007022:Hypotension / Q000188:drug therapy*; D014662:Vasoconstrictor Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
D014662:Vasoconstrictor Agents
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