title: Epigenetic profiling in schizophrenia and major mental disorders.
abstract: Epigenetic alterations such as DNA methylation and histone modifications are important in the etiology or pathophysiology of mental disorders. Here, we review recent studies on the relationship between DNA methylation and major mental disorders. We will focus on the role of DNA methylation in postmitotic neurons, intra- and interindividual variations in DNA methylation, the possible involvement of methionine metabolism pathways, and candidate and genome-wide DNA methylation as they relate to mental disorders.
authors.affiliation: Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako, Japan. kaziwamoto@brain.riken.jp
authors.forename: Kazuya
authors.initials: K
authors.lastname: Iwamoto
authors.forename: Tadafumi
authors.initials: T
authors.lastname: Kato
mesh_terms: D019175:DNA Methylation; D044127:Epigenesis, Genetic; D006801:Humans; D001523:Mental Disorders / Q000235:genetics* / Q000378:metabolism; D008715:Methionine / Q000235:genetics / Q000378:metabolism; D012559:Schizophrenia / Q000235:genetics* / Q000378:metabolism
chemical_list: D008715:Methionine