title: Characterization of c-Maf transcription factor in normal and neoplastic hematolymphoid tissue and its relevance in plasma cell neoplasia.
abstract: c-Maf, a leucine zipper-containing transcription factor, is involved in the t(14;16)(q32;q23) translocation found in 5% of myelomas. A causal role for c-Maf in myeloma pathogenesis has been proposed, but data on c-Maf protein expression are lacking. We therefore studied the expression of c-Maf protein by immunohistochemical analysis in myelomas and in a wide variety of hematopoietic tissue. c-Maf protein was detected in a small minority (4.3%) of myelomas, including a t(14;16)(q32;q22-23)/IgH-Maf+ case, suggesting that c-Maf protein is not expressed in the absence of c-Maf rearrangement. In contrast, c-Maf was strongly expressed in hairy cell leukemia (4/4) and in a significant proportion of T-cell (24/42 [57%]) and NK/T-cell (49/97 [51%]) lymphomas, which is in keeping with prior gene expression profiling and transgenic mouse studies. Up-regulation of c-Maf protein occurs in a small subset of myelomas, in hairy cell leukemia, and in T- and NK-cell neoplasms. Its detection may be of particular value in the differential diagnosis of small cell lymphomas.
authors.affiliation: Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
authors.forename: Yasodha
authors.initials: Y
authors.lastname: Natkunam
authors.forename: Sara
authors.initials: S
authors.lastname: Tedoldi
authors.forename: Jennifer C
authors.initials: JC
authors.lastname: Paterson
authors.forename: Shuchun
authors.initials: S
authors.lastname: Zhao
authors.forename: Manuel
authors.initials: M
authors.lastname: Rodriguez-Justo
authors.forename: Andrew H
authors.initials: AH
authors.lastname: Beck
authors.forename: Reiner
authors.initials: R
authors.lastname: Siebert
authors.forename: David Y
authors.initials: DY
authors.lastname: Mason
authors.forename: Teresa
authors.initials: T
authors.lastname: Marafioti
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D015153:Blotting, Western; D015870:Gene Expression; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D008223:Lymphoma / Q000235:genetics / Q000378:metabolism*; D009101:Multiple Myeloma / Q000235:genetics / Q000378:metabolism*; D014066:Palatine Tonsil / Q000378:metabolism; D051257:Proto-Oncogene Proteins c-maf / Q000096:biosynthesis*
chemical_list: D014408:Biomarkers, Tumor; C495607:MAF protein, human; D051257:Proto-Oncogene Proteins c-maf
references.citation: Leuk Lymphoma. 2003 Oct;44(10):1761-6
references.pmid: 14692531
references.citation: Oncologist. 2006 Jul-Aug;11(7):780-9
references.pmid: 16880237
references.citation: Blood. 1998 Jun 15;91(12):4457-63
references.pmid: 9616139
references.citation: Semin Hematol. 2006 Apr;43(2 Suppl 2):S11-21
references.pmid: 16549109
references.citation: Oncol Rep. 2007 Nov;18(5):1099-106
references.pmid: 17914559
references.citation: Nat Immunol. 2006 May;7(5):466-74
references.pmid: 16565720
references.citation: Nat Rev Cancer. 2002 Mar;2(3):175-87
references.pmid: 11990854
references.citation: Blood. 1999 Sep 1;94(5):1578-89
references.pmid: 10477683
references.citation: Oncogene. 2006 Mar 2;25(9):1299-310
references.pmid: 16247450
references.citation: Cell. 1996 Jun 28;85(7):973-83
references.pmid: 8674125
references.citation: Blood. 2005 May 15;105(10):3979-86
references.pmid: 15677569
references.citation: Proc Natl Acad Sci U S A. 1998 Dec 8;95(25):14863-8
references.pmid: 9843981
references.citation: Nat Rev Cancer. 2006 Jun;6(6):437-48
references.pmid: 16723990
references.citation: Leukemia. 2005 Mar;19(3):449-55
references.pmid: 15674420
references.citation: Am J Clin Pathol. 2004 Feb;121(2):254-63
references.pmid: 14983940
references.citation: Hematology Am Soc Hematol Educ Program. 2005;:346-52
references.pmid: 16304402
references.citation: Cancer Genet Cytogenet. 2005 Jan 15;156(2):150-3
references.pmid: 15642395
references.citation: J Clin Oncol. 2005 Sep 10;23(26):6333-8
references.pmid: 16155016
references.citation: J Exp Med. 2004 Jan 5;199(1):59-68
references.pmid: 14707115
references.citation: Am J Surg Pathol. 2005 Apr;29(4):474-8
references.pmid: 15767800
references.citation: Br J Haematol. 2005 Feb;128(3):333-42
references.pmid: 15667535
references.citation: Pancreas. 2006 May;32(4):408-16
references.pmid: 16670624
references.citation: Genes Chromosomes Cancer. 2005 Feb;42(2):117-27
references.pmid: 15543617
references.citation: Oncogene. 2005 Apr 7;24(15):2461-73
references.pmid: 15735737
references.citation: Leukemia. 2001 May;15(5):840-5
references.pmid: 11368447
references.citation: Blood. 2006 Jan 1;107(1):213-21
references.pmid: 16160011
references.citation: Cancer Cell. 2004 Feb;5(2):191-9
references.pmid: 14998494
references.citation: Immunity. 1999 Jun;10(6):745-51
references.pmid: 10403649
references.citation: J Pathol. 2005 May;206(1):76-86
references.pmid: 15772984
references.citation: Lancet. 2004 Jun 5;363(9424):1869-70
references.pmid: 15183626
references.citation: Cancer Res. 2006 Jan 15;66(2):812-9
references.pmid: 16424013
references.citation: Blood. 2004 Jan 1;103(1):188-93
references.pmid: 12881301
references.citation: J Mol Biol. 2005 Aug 19;351(3):453-69
references.pmid: 16023139
references.citation: Mod Pathol. 2001 Jul;14(7):686-94
references.pmid: 11455001
references.citation: Haematologica. 2006 Apr;91(4):467-74
references.pmid: 16585013
references.citation: J Clin Oncol. 2005 Sep 10;23(26):6339-44
references.pmid: 16155017
references.citation: Nat Immunol. 2006 May;7(5):457-65
references.pmid: 16565721
references.citation: Proc Natl Acad Sci U S A. 1989 Oct;86(20):7711-5
references.pmid: 2554284
references.citation: Leukemia. 2000 Mar;14(3):449-56
references.pmid: 10720141