title: A review of lipidomic technologies applicable to sphingolipidomics and their relevant applications.
abstract: Sphingolipidomics, a branch of lipidomics, focuses on the large-scale study of the cellular sphingolipidomes. In the current review, two main approaches for the analysis of cellular sphingolipidomes (i.e. LC-MS- or LC-MS/MS-based approach and shotgun lipidomics-based approach) are briefly discussed. Their advantages, some considerations of these methods, and recent applications of these approaches are summarized. It is the authors' sincere hope that this review article will add to the readers understanding of the advantages and limitations of each developed method for the analysis of a cellular sphingolipidome.
authors.affiliation: Division of Bioorganic Chemistry and Molecular Pharmacology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, USA.
authors.forename: Xianlin
authors.initials: X
authors.lastname: Han
authors.forename: Xuntian
authors.initials: X
authors.lastname: Jiang
references.citation: Mol Genet Metab. 2008 Apr;93(4):437-43
references.pmid: 18162427
references.citation: Cell Mol Biol (Noisy-le-grand). 2003 Jul;49(5):779-87
references.pmid: 14528915
references.citation: J Lipid Res. 2004 Feb;45(2):281-6
references.pmid: 14595000
references.citation: FASEB J. 2006 Jun;20(8):1152-61
references.pmid: 16770014
references.citation: Anal Biochem. 2000 May 15;281(1):36-44
references.pmid: 10847608
references.citation: Cell Mol Biol (Noisy-le-grand). 2003 Jul;49(5):809-18
references.pmid: 14528918
references.citation: Yeast. 2006 Apr 30;23(6):465-77
references.pmid: 16652392
references.citation: Arch Pathol Lab Med. 2004 Dec;128(12):1337-45
references.pmid: 15578876
references.citation: Prostaglandins Other Lipid Mediat. 2005 Sep;77(1-4):15-22
references.pmid: 16099387
references.citation: J Biol Chem. 2004 Jun 18;279(25):26167-75
references.pmid: 15078881
references.citation: J Lipid Res. 2001 Dec;42(12):1959-68
references.pmid: 11734568
references.citation: Mol Genet Metab. 2007 Dec;92(4):336-45
references.pmid: 17881272
references.citation: Anal Chem. 2006 Sep 1;78(17):6202-14
references.pmid: 16944903
references.citation: Anal Biochem. 2005 Apr 1;339(1):129-36
references.pmid: 15766719
references.citation: Anal Chem. 2007 Jun 1;79(11):4083-93
references.pmid: 17474710
references.citation: J Lipid Res. 1999 Aug;40(8):1539-46
references.pmid: 10428992
references.citation: Lipids. 2007 Apr;42(3):275-90
references.pmid: 17393232
references.citation: Front Biosci. 2007 Jan 01;12:2750-60
references.pmid: 17127277
references.citation: Nat Rev Drug Discov. 2005 Jul;4(7):594-610
references.pmid: 16052242
references.citation: Anal Biochem. 2001 Aug 1;295(1):88-100
references.pmid: 11476549
references.citation: Methods Enzymol. 2007;433:175-91
references.pmid: 17954235
references.citation: J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Jun 1;852(1-2):562-70
references.pmid: 17368999
references.citation: Front Biosci. 2007 Jan 01;12:2494-506
references.pmid: 17127258
references.citation: Anal Biochem. 2007 Dec 15;371(2):135-45
references.pmid: 17920553
references.citation: Annu Rev Anal Chem (Palo Alto Calif). 2008;1:357-96
references.pmid: 20636083
references.citation: J Lipid Res. 2005 Jul;46(7):1548-60
references.pmid: 15834120
references.citation: J Lipid Res. 2003 Nov;44(11):2209-16
references.pmid: 12897185
references.citation: Anal Chem. 2002 Mar 1;74(5):941-9
references.pmid: 11924996
references.citation: Proc Natl Acad Sci U S A. 1997 Mar 18;94(6):2339-44
references.pmid: 9122196
references.citation: Anal Biochem. 2005 May 1;340(1):113-22
references.pmid: 15802137
references.citation: Exp Biol Med (Maywood). 2007 Apr;232(4):471-2
references.pmid: 17392481
references.citation: J Biol Chem. 1966 Aug 25;241(16):3724-30
references.pmid: 5916387
references.citation: Biochim Biophys Acta. 2003 Nov 15;1634(3):61
references.pmid: 14643793
references.citation: J Lipid Res. 2006 Jul;47(7):1559-71
references.pmid: 16639079
references.citation: Prostaglandins Other Lipid Mediat. 2005 Sep;77(1-4):4-14
references.pmid: 16099386
references.citation: J Am Soc Mass Spectrom. 2006 Feb;17(2):264-74
references.pmid: 16413201
references.citation: Expert Rev Proteomics. 2005 Apr;2(2):253-64
references.pmid: 15892569
references.citation: J Lipid Res. 2002 Jul;43(7):1125-32
references.pmid: 12091497
references.citation: J Lipid Res. 2003 Jun;44(6):1071-9
references.pmid: 12671038
references.citation: Anal Biochem. 2002 Mar 15;302(2):199-212
references.pmid: 11878798
references.citation: J Mass Spectrom. 2006 Mar;41(3):372-89
references.pmid: 16498600
references.citation: Front Biosci. 2007 Jan 01;12:2568-79
references.pmid: 17127263
references.citation: Anal Chem. 2005 Apr 1;77(7):2166-75
references.pmid: 15801751
references.citation: Nat Rev Mol Cell Biol. 2003 May;4(5):397-407
references.pmid: 12728273
references.citation: J Lipid Res. 2004 Sep;45(9):1777-82
references.pmid: 15210839
references.citation: J Biol Chem. 2003 Mar 7;278(10):8043-51
references.pmid: 12501252
references.citation: J Biol Chem. 2002 Aug 30;277(35):31994-2002
references.pmid: 12077151
references.citation: Methods. 2005 Jun;36(2):207-24
references.pmid: 15894491
references.citation: J Neurochem. 2007 Apr;101(1):57-76
references.pmid: 17241120
references.citation: J Neurochem. 2007 Nov;103 Suppl 1:3-13
references.pmid: 17986134
references.citation: Biochim Biophys Acta. 2007 Apr;1768(4):923-40
references.pmid: 17078925
references.citation: Microbiol Mol Biol Rev. 2005 Jun;69(2):197-216
references.pmid: 15944454
references.citation: Curr Opin Mol Ther. 2007 Dec;9(6):586-91
references.pmid: 18041669
references.citation: Front Biosci. 2007 Jan 01;12:2601-15
references.pmid: 17127266
references.citation: J Lipid Res. 1970 Jan;11(1):23-30
references.pmid: 4983716
references.citation: Anal Biochem. 2004 Jul 15;330(2):317-31
references.pmid: 15203339
references.citation: EMBO Rep. 2004 Aug;5(8):777-82
references.pmid: 15289826
references.citation: Methods. 2006 Jun;39(2):82-91
references.pmid: 16828308
references.citation: J Lipid Res. 2006 Oct;47(10):2101-11
references.pmid: 16902246
references.citation: Mol Interv. 2004 Apr;4(2):86-96
references.pmid: 15087482
references.citation: Mass Spectrom Rev. 2005 May-Jun;24(3):367-412
references.pmid: 15389848
references.citation: Sci STKE. 2001 Jan 30;2001(67):pl1
references.pmid: 11752637
references.citation: Biochem J. 2008 Feb 15;410(1):81-92
references.pmid: 17939778
references.citation: Biochim Biophys Acta. 2006 Dec;1758(12):1864-84
references.pmid: 17052686
references.citation: J Mass Spectrom. 2001 Aug;36(8):849-65
references.pmid: 11523084
references.citation: Front Biosci. 2007 May 01;12:3203-46
references.pmid: 17485294
references.citation: Biochemistry. 2004 Dec 14;43(49):15584-94
references.pmid: 15581371
references.citation: Anal Chem. 2006 Jan 15;78(2):585-95
references.pmid: 16408944
references.citation: Anal Biochem. 2005 Jun 15;341(2):251-8
references.pmid: 15907870
references.citation: Rapid Commun Mass Spectrom. 2003;17(19):2168-76
references.pmid: 14515314
references.citation: Prostaglandins Other Lipid Mediat. 2005 Sep;77(1-4):35-45
references.pmid: 16099389
references.citation: Proc Natl Acad Sci U S A. 1994 Oct 25;91(22):10635-9
references.pmid: 7938005