Synthesis and characterization of ultra-small superparamagnetic iron oxide nanoparticles thinly coated with silica.
Ultra-small superparamagnetic iron oxide nanoparticles (SPIOs) were synthesized by co-precipitation of iron chloride salts with ammonia and then encapsulated with thin (~2nm) layers of silica. The particles have been characterized for size, diffraction pattern, surface charge, and magnetic properties. This rapid and economical synthesis has a number of industrial applications; however, the silica-coated particles have been optimized for use in medical applications as MR contrast agents, biosensors, DNA capturing, bioseparation and enzyme immobilization.
Bumb
A
A
Oxford University Begbroke Science Park, Sandy Lane, Kidlington, Oxon OX5 1PF, UK. Email: Ambika.Bumb@eng.ox.ac.uk , Peter.Dobson@begbroke.ox.ac.uk.
Brechbiel
M W
MW
Choyke
P L
PL
Fugger
L
L
Eggeman
A
A
Prabhakaran
D
D
Hutchinson
J
J
Dobson
P J
PJ
Biomaterials. 2005 Jun;26(18):3995-4021
15626447
Science. 1974 May 3;184(4136):585-6
4821961
Eur Radiol. 2001;11(11):2319-31
11702180
J Am Chem Soc. 2003 Mar 12;125(10):3150-8
12617683
Analyst. 2001 Aug;126(8):1274-8
11534592
Nat Biotechnol. 2004 Feb;22(2):211-3
14716316
Magn Reson Med. 1993 May;29(5):599-604
8505895
J Colloid Interface Sci. 1998 Sep 15;205(2):205-212
9735184
J Chromatogr. 1988 Jun 29;443:55-62
2459150
Nanotechnology. 2008 Feb 27;19(8):085601
21730725
Nat Mater. 2003 Mar;2(3):145-50
12612669
Int J Pharm. 2000 Mar 10;196(2):257-61
10699731
Anal Chem. 2001 Oct 15;73(20):4988-93
11681477
J Biosci Bioeng. 2002;94(6):606-13
16233357
Chem Rev. 1996 Jun 20;96(4):1533-1554
11848802
Biotechniques. 1996 Nov;21(5):876-80
8922629
Jpn J Cancer Res. 1998 Apr;89(4):463-9
9617354
Jpn J Cancer Res. 1997 Jul;88(7):630-2
9310134