Serotonin transporter promoter variant: Analysis in Indian IBS patients and control population.
BACKGROUND
Studies of serotonin reuptake transporter (SERT-P) polymorphism and irritable bowel syndrome (IBS) have shown diverse results among different populations, which might be due to racial and ethnic difference.


OBJECTIVE
This study was to investigate the potential association between the SERT-P polymorphism and clinical subtypes of IBS patients in the Indian population.


METHODS
This prospective case-control study included 151 IBS patients. Ninety-two patients were diarrhea-predominant IBS, 44 were constipation-predominant IBS (C-IBS), 15 were alternating diarrhea and constipation IBS, and 100 were healthy controls. SERT gene polymorphism was studied by polymerase chain reaction.


RESULTS
A genotypic association was observed between SS genotype of SERT-P polymorphism and C-IBS (P<0.05). When the L/S and L/L genotypes were combined into one group, the frequency of the S/S genotype was significantly higher than that of the non-S/S genotype between C-IBS and the control group (P<0.05). There was no significant difference in the SERT-P genotype and allele frequency between c-ibs, alternating diarrhea and constipation IBS, all types of IBS cases, and controls.


CONCLUSIONS
A significant association was observed between the SS genotype of SERT-P polymorphism and C-IBS in the Indian population.
Sikander
Arbab
A
Department of Super Specialty of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Rana
Satya Vati
SV
Sinha
Saroj Kant
SK
Prasad
Kaushal Kishor
KK
Arora
Sunil K
SK
Sharma
Sanjeev Kumar
SK
Singh
Kartar
K
D000328:Adult; D016022:Case-Control Studies; D003248:Constipation / Q000209:etiology; D003967:Diarrhea / Q000209:etiology; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007194:India; D043183:Irritable Bowel Syndrome / Q000208:ethnology / Q000235:genetics* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011446:Prospective Studies; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*
C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins