title: Genetic variation in the G72 (DAOA) gene affects temporal lobe and amygdala structure in subjects affected by bipolar disorder.
abstract: BACKGROUND
  Variation in the G72 (DAOA) gene is understood to convey susceptibility for bipolar disorder through an uncertain mechanism. Little is known about the structural brain phenotypes associated with this gene. We hypothesised that reductions in temporal lobe and amygdala gray matter would be associated with variation at two loci in the gene for which evidence of genetic linkage has been repeatedly demonstrated.
  
  
  METHODS
  We examined the temporal lobe and amygdala gray matter associations of the risk variants M23 and M24 at the 5' end of the gene encoding G72 in 81 controls and 38 people with bipolar disorder.
  
  
  RESULTS
  Genetic variation at both the M23 and M24 loci in G72 were associated with decreased gray matter density within the left temporal pole in people with bipolar disorder. M23 was also associated with reductions in right amygdala gray matter density. The genetic imaging associations were found only in patients with bipolar disorder.
  
  
  CONCLUSIONS
  Genetic variation at single nucleotide polymorphisms in the G72 gene previously associated with bipolar disorder is related to reductions in temporal pole and amygdala gray matter structure in people with bipolar disorder.
authors.affiliation: Clinica di Psichiatria, Psicologia Medica e Psicosomatica, DPMSC, University of Udine, Udine, Italy.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Zuliani
authors.forename: T William J
authors.initials: TW
authors.lastname: Moorhead
authors.forename: Dominic
authors.initials: D
authors.lastname: Job
authors.forename: James
authors.initials: J
authors.lastname: McKirdy
authors.forename: Jessika E D
authors.initials: JE
authors.lastname: Sussmann
authors.forename: Eve C
authors.initials: EC
authors.lastname: Johnstone
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Lawrie
authors.forename: Paolo
authors.initials: P
authors.lastname: Brambilla
authors.forename: Jeremy
authors.initials: J
authors.lastname: Hall
authors.forename: Andrew M
authors.initials: AM
authors.lastname: McIntosh
mesh_terms: D000328:Adult; D000679:Amygdala / Q000473:pathology*; D001714:Bipolar Disorder / Q000235:genetics* / Q000473:pathology*; D002352:Carrier Proteins / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D013702:Temporal Lobe / Q000473:pathology*
chemical_list: D002352:Carrier Proteins; C475071:DAOA protein, human; D047908:Intracellular Signaling Peptides and Proteins