Cellular morphogenesis in silico.
We describe a model that simulates spherical cells of different types that can migrate and interact either attractively or repulsively. We find that both expected morphologies and previously unreported patterns spontaneously self-assemble. Among the newly discovered patterns are a segmented state of alternating discs, and a "shish-kebab" state, in which one cell type forms a ring around a second type. We show that these unique states result from cellular attraction that increases with distance (e.g., as membranes stretch viscoelastically), and would not be seen in traditional, e.g., molecular, potentials that diminish with distance. Most of the states found computationally have been observed in vitro, and it remains to be established what role these self-assembled states may play in in vivo morphogenesis.
Shinbrot
Troy
T
Department of Biomedical Engineering, Rutgers University, Piscataway, New Jersey 08854, USA. shinbrot@soemail.rutgers.edu
Chun
Young
Y
Caicedo-Carvajal
Carlos
C
Foty
Ramsey
R
D000818:Animals; D002450:Cell Communication / Q000502:physiology*; D002465:Cell Movement; D048429:Cell Size; D003198:Computer Simulation; D006801:Humans; D008954:Models, Biological; D009024:Morphogenesis / Q000502:physiology*
Proc Natl Acad Sci U S A. 1984 Mar;81(5):1460-4
6584892
Phys Rev E Stat Nonlin Soft Matter Phys. 2001 Jan;63(1 Pt 2):017101
11304390
Nature. 2003 Apr 10;422(6932):583-8
12660735
Phys Rev Lett. 1994 Apr 4;72(14):2298-2301
10055839
Genes Dev. 1998 Mar 1;12(5):667-78
9499402
J Biol Chem. 2005 Jan 7;280(1):137-45
15504723
Cell. 1996 May 3;85(3):357-68
8616891
Cell. 1996 Sep 6;86(5):755-66
8797822
Development. 2003 Oct;130(19):4497-500
12925578
Science. 1963 Aug 2;141(3579):401-8
13983728
Nature. 1999 Jul 1;400(6739):77-81
10403252
Development. 2002 Jan;129(1):13-24
11782397
Cell. 1997 Aug 8;90(3):403-4
9267020
Phys Rev Lett. 2000 Feb 7;84(6):1240-3
11017488
Nat Cell Biol. 2003 Oct;5(10):851-3
14523393
Nat Rev Neurosci. 2000 Nov;1(2):116-24
11252774
Ann Biomed Eng. 2002 Mar;30(3):305-14
12051616
Curr Biol. 2005 Mar 29;15(6):536-42
15797022
Int J Dev Biol. 2004;48(5-6):397-409
15349815
Dev Biol. 2003 Jan 15;253(2):309-23
12645933
Nature. 1980 Oct 30;287(5785):795-801
6776413
Philos Trans R Soc Lond B Biol Sci. 2015 Apr 19;370(1666):
25750229
Development. 2002 Jun;129(11):2577-89
12015287
Dev Biol. 2005 Aug 15;284(2):523-35
15982648
Annu Rev Biomed Eng. 2005;7:187-221
16004570
Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics. 1994 Jul;50(1):R28-R31
9962022
Nat Rev Mol Cell Biol. 2002 Jul;3(7):475-86
12094214
Development. 2003 Aug;130(15):3447-57
12810592
Development. 1997 Feb;124(4):871-80
9043068
Biophys J. 1998 Jan;74(1):514-22
9449351
Annu Rev Biomed Eng. 2000;2:189-226
11701511
J Theor Biol. 2007 Jul 7;247(1):186-204
17416390
BMC Neurosci. 2004 Jul 08;5:22
15242518
Bull Math Biol. 2004 Jan;66(1):167-93
14670535
Dev Biol. 2001 Jun 15;234(2):470-82
11397014
EMBO J. 1994 Sep 15;13(18):4212-22
7925267
Nature. 1999 May 20;399(6733):267-71
10353250
Development. 1993 Apr;117(4):1183-98
8404525
J Biol Chem. 1995 Mar 10;270(10):5636-41
7890684
J Theor Biol. 2006 Oct 7;242(3):764-73
16780892
Nat Mater. 2003 May;2(5):329-32
12704382
Trends Biochem Sci. 2004 Jul;29(7):364-70
15236744
Development. 1996 May;122(5):1611-20
8625847
Cell. 1996 Feb 9;84(3):359-69
8608589
Mol Biol Cell. 2004 Mar;15(3):973-81
14718567
Mech Dev. 2007 Apr;124(4):318-26
17293093
Hepatology. 2008 Apr;47(4):1394-400
18307210
Ann Biomed Eng. 2005 Nov;33(11):1469-90
16341917
Dev Biol. 2008 Mar 15;315(2):397-403
18272146
Annu Rev Biochem. 2000;69:277-302
10966460
Heredity (Edinb). 2006 Sep;97(3):200-10
16835593
Biophys J. 1991 Apr;59(4):838-48
2065188
J Biomech Eng. 2003 Jun;125(3):334-41
12929237
Proc Natl Acad Sci U S A. 2000 Sep 12;97(19):10448-53
10984537