Small molecule ligands for bulged RNA secondary structures.
A class of wedge-shaped small molecules has been designed, synthesized, and shown to bind bulged RNA secondary structures. These minimally cationic ligands exhibit good affinity and selectivity for certain RNA bulges as demonstrated in a fluorescent intercalator displacement assay.
Meyer
S Todd
ST
Department of Chemistry, Roger Adams Laboratory, University of Illinois, Urbana, Illinois 61801, USA.
Hergenrother
Paul J
PJ
D054856:G-Quadruplexes / Q000187:drug effects*; D007364:Intercalating Agents / Q000494:pharmacology*; D008956:Models, Chemical; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D012313:RNA / Q000737:chemistry*; D013329:Structure-Activity Relationship
D007364:Intercalating Agents; D012313:RNA
Chem Biol. 2002 Aug;9(8):925-31
12204692
Chembiochem. 2003 Oct 6;4(10):998-1007
14523917
Science. 1996 Jun 28;272(5270):1943-6
8658168
Chemistry. 2006 Mar 8;12(9):2488-503
16389623
J Med Chem. 1989 Feb;32(2):391-6
2521519
Biochemistry. 2003 Oct 7;42(39):11391-403
14516190
Chem Rev. 1997 Aug 5;97(5):1489-1514
11851457
Curr Opin Chem Biol. 2000 Dec;4(6):678-86
11102874
Org Lett. 2004 Dec 23;6(26):4833-6
15606078
Biochemistry. 2003 Jul 22;42(28):8472-83
12859193
Chem Rev. 2008 Apr;108(4):1171-224
18361529
Biochemistry. 2006 Sep 12;45(36):10928-38
16953578
Biochemistry. 2007 Jan 16;46(2):561-7
17209566
Bioorg Med Chem. 2009 Mar 15;17(6):2428-32
19243952
Acc Chem Res. 2001 Oct;34(10):836-43
11601968
J Am Chem Soc. 2004 Aug 4;126(30):9196-7
15281805
J Am Chem Soc. 2001 Jun 27;123(25):5878-91
11414820
Chem Commun (Camb). 2006 Nov 13;(42):4431-3
17057867
J Am Chem Soc. 2005 Sep 14;127(36):12434-5
16144359
Curr Top Med Chem. 2008;8(6):436-47
18397167
Angew Chem Int Ed Engl. 2002 Apr 15;41(8):1386-9
19750773