Premature ejaculation.
Premature ejaculation (PE) is a common male sexual disorder. Recent normative data suggests that men with an intravaginal ejaculatory latency time (IELT) of less than 1 minute have "definite" PE, while men with IELTs between 1 and 1.5 minutes have "probable" PE. Although there is insufficient empirical evidence to identify the etiology of PE, there is limited correlational evidence to suggest that men with PE have high levels of sexual anxiety and inherited altered sensitivity of central 5-HT (5-hydroxytryptamine, serotonin) receptors. Pharmacological modulation of the ejaculatory threshold using off-label daily or on-demand selective serotonin re-uptake inhibitors is well tolerated and offers patients a high likelihood of achieving improved ejaculatory control within a few days of initiating treatment, consequential improvements in sexual desire and other sexual domains. Investigational drugs such as the ejaculo-selective serotonin transport inhibitor, dapoxetine represent a major development in sexual medicine. These drugs offer patients the convenience of on-demand dosing, significant improvements in IELT, ejaculatory control and sexual satisfaction with minimal adverse effects.
McMahon
Chris G
CG
Australian Centre For Sexual Health Suite 2-4, Berry Road Medical Centre 1a Berry Rd St. Leonards, Australia.
Br J Psychiatry. 1987 Jul;151:107-12
3315086
J Abnorm Psychol. 1984 May;93(2):242-5
6725760
J Sex Marital Ther. 2000 Oct-Dec;26(4):293-320
11056895
J Sex Marital Ther. 1999 Apr-Jun;25(2):89-101
10327378
Arch Sex Behav. 1987 Aug;16(4):327-36
3675186
Psychiatr Genet. 1998 Spring;8(1):37-40
9564687
Neurosci Lett. 1996 Feb 9;204(3):215-7
8938269
J Clin Psychopharmacol. 1998 Aug;18(4):274-81
9690692
Neuroreport. 1993 Oct 25;5(1):87-9
8280866
J Sex Med. 2005 Jul;2(4):508-12
16422845
J Urol. 2002 Dec;168(6):2486-9
12441946
South Med J. 1956 Apr;49(4):353-8
13311629
Clin Neuropharmacol. 2004 May-Jun;27(3):150-1
15190240
Arch Sex Behav. 1997 Feb;26(1):27-47
9015578
Int J Impot Res. 2004 Dec;16(6):547-51
15057258
J Obstet Gynaecol. 2006 Oct;26(7):682-6
17071440
Brain Res. 1992 Nov 20;596(1-2):73-9
1468004
Arch Sex Behav. 1985 Dec;14(6):467-89
4084048
Int J Androl. 2002 Oct;25(5):301-5
12270028
Science. 2002 Aug 30;297(5586):1566-9
12202834
Int J Impot Res. 2006 Jan-Feb;18(1):104-10
16307008
BJU Int. 2007 Feb;99(2):369-75
17129234
J Sex Med. 2005 Jul;2(4):492-7
16422843
Yonsei Med J. 1997 Apr;38(2):91-5
9175486
J Urol. 1999 Jun;161(6):1826-30
10332446
Int J Impot Res. 2003 Jun;15(3):225-8
12904810
Urology. 2003 Jun;61(6):1079-85
12809865
Arch Sex Behav. 1998 Jun;27(3):309-14
9604119
BJU Int. 2004 May;93(7):1018-21
15142155
J Urol. 1995 Oct;154(4):1360-1
7658537
Urology. 1999 Sep;54(3):544-7
10475369
J Sex Marital Ther. 2003 Oct-Dec;29(5):361-70
14504007
Arch Gen Psychiatry. 1982 May;39(5):614-9
7092493
Physiol Behav. 1999 Oct;67(4):561-6
10549894
Neuroreport. 1996 Dec 20;8(1):31-4
9051747
Asian J Androl. 2004 Jun;6(2):121-6
15154086
Andrologia. 2009 Jun;41(3):169-75
19400851
J Reprod Fertil. 1984 Jan;70(1):197-202
6694137
Int J Impot Res. 2004 Aug;16(4):369-81
14961051
Br J Med Psychol. 1986 Dec;59(4):351-8
3801344
Am J Physiol. 1998 Jan;274(1):R243-7
9458924
J Urol. 2004 Jul;172(1):290-4
15201797
Hum Reprod. 2000 Jan;15(1):131-4
10611201
Pharmacol Biochem Behav. 1981 Nov;15(5):785-92
6458826
Arch Sex Behav. 2003 Jun;32(3):261-70
12807298
Int J Impot Res. 2007 May-Jun;19(3):321-5
17136103
Lancet. 2006 Sep 9;368(9539):929-37
16962882
Urology. 2006 Feb;67(2):388-91
16461091
J Sex Med. 2005 May;2(3):358-67
16422867
Arch Sex Behav. 1974 Sep;3(5):443-52
4413604
Arch Sex Behav. 1990 Aug;19(4):389-408
2205172
Br J Psychiatry. 1991 Nov;159:691-5
1756347
J Urol. 2002 Dec;168(6):2359-67
12441918
Behav Res Ther. 1986;24(6):665-75
3800838
Zhonghua Nan Ke Xue. 2004 May;10(5):366-7, 370
15190831
Arch Sex Behav. 1986 Apr;15(2):157-65
3718204
Int J Impot Res. 2001 Feb;13(1):41-5
11313839
Behav Brain Res. 1998 May;92(2):111-8
9638953
J Reprod Med. 1981 Oct;26(10):499-507
7310763
Arch Sex Behav. 1980 Dec;9(6):457-75
7458655
Psychopharmacol Bull. 1989;25(1):36-40
2672070
J Sex Marital Ther. 2006 Mar-Apr;32(2):97-114
16418103
Int J Impot Res. 2005 Jan-Feb;17(1):39-57
15215881
J Sex Med. 2005 May;2(3):376-82
16422869
J Sex Med. 2004 Sep;1(2):225-32
16429622
BJU Int. 2006 Sep;98(3):613-8
16925762
Arch Sex Behav. 2001 Jun;30(3):235-53
11330115
Eur Urol. 2007 Mar;51(3):816-23; discussion 824
16934919
Am J Public Health. 2003 Jun;93(6):894-8
12773346
Depress Anxiety. 2006;23(3):153-7
16502416
J Sex Med. 2005 Jul;2(4):498-507
16422844
Urology. 2003 Feb;61(2):479-83
12597985
Int J Clin Pract. 2005 Dec;59(12):1482-7
16351684
Am J Psychiatry. 1976 Jan;133(1):82-5
1247127
BJU Int. 2006 Aug;98(2):259-72
16879663
Aust N Z J Psychiatry. 1984 Dec;18(4):333-40
6596940
Arch Sex Behav. 1979 Jan;8(1):81-100
369478
J Clin Psychopharmacol. 2006 Feb;26(1):27-31
16415702
J Sex Marital Ther. 1986 Winter;12(4):267-81
3493350
Urology. 2003 Jan;61(1):197-200
12559295
Neuropharmacology. 1994 Nov;33(11):1499-504
7532834
Int Clin Psychopharmacol. 1998 Jul;13 Suppl 6:S9-14
9728669
Zhonghua Nan Ke Xue. 2005 Jul;11(7):520-2, 525
16078671
Int J Impot Res. 2003 Oct;15(5):309-13
14562129
Arzneimittelforschung. 1996 Nov;46(11):1029-36
8955860
J Sex Med. 2006 Mar;3(2):337-43
16490029
Eur Urol. 2004 Nov;46(5):555-8
15474262
Int J Psychiatry Clin Pract. 1998;2(4):287-93
24927094
Arch Sex Behav. 1984 Feb;13(1):69-83
6712463
J Sex Med. 2005 May;2(3):368-75
16422868
Nucl Med Biol. 1994 May;21(4):669-75
9234326
Anaesth Intensive Care. 2004 Aug;32(4):575-7
15675220
JAMA. 1999 Feb 10;281(6):537-44
10022110
Zhonghua Nan Ke Xue. 2003;9(4):266-9
12931367
Acta Psychiatr Belg. 1986 Jan-Feb;86(1):57-63
3962693
Arch Sex Behav. 1990 Jun;19(3):251-7
2360874
J Sex Med. 2006 May;3(3):465-75
16681472