Effect of dexamethasone on differentiation of multipotent stromal cells from human adipose tissue.
Effect of dexamethasone on differentiation of multipotent stromal cells from human adipose tissue was evaluated. Addition of dexamethasone to growth medium resulted in active adipogenesis. Addition of dexamethasone to the osteogenic medium (containing active vitamin D3 form as the main inductor) led to simultaneous realization of the adipogenic and osteogenic potencies of multipotent stromal cells of the adipose tissue. Hence, the quality of the transplant on the basis of predifferentiated multipotent stromal cells from the adipose tissue for bone tissue repair can be deteriorated by dexamethasone directing some cells to adipogenic development.
Arutyunyan
I V
IV
ReMeTex Company, Moscow. remetex@yandex.ru
Rzhaninova
A A
AA
Volkov
A V
AV
Goldstein
D V
DV
D050156:Adipogenesis / Q000187:drug effects; D000273:Adipose Tissue / Q000166:cytology / Q000187:drug effects* / Q000502:physiology*; D000469:Alkaline Phosphatase / Q000378:metabolism; D018931:Antineoplastic Agents, Hormonal / Q000494:pharmacology*; D002454:Cell Differentiation / Q000187:drug effects*; D002478:Cells, Cultured; D002762:Cholecalciferol / Q000378:metabolism; D003470:Culture Media; D003907:Dexamethasone / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D039902:Multipotent Stem Cells / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D015675:Osteocalcin / Q000378:metabolism; D010012:Osteogenesis / Q000187:drug effects; D017154:Stromal Cells / Q000166:cytology / Q000187:drug effects / Q000502:physiology
D018931:Antineoplastic Agents, Hormonal; D003470:Culture Media; D015675:Osteocalcin; D002762:Cholecalciferol; D003907:Dexamethasone; D000469:Alkaline Phosphatase