Quorum sensing and social networking in the microbial world.
For many years, bacterial cells were considered primarily as selfish individuals, but, in recent years, it has become evident that, far from operating in isolation, they coordinate collective behaviour in response to environmental challenges using sophisticated intercellular communication networks. Cell-to-cell communication between bacteria is mediated by small diffusible signal molecules that trigger changes in gene expression in response to fluctuations in population density. This process, generally referred to as quorum sensing (QS), controls diverse phenotypes in numerous Gram-positive and Gram-negative bacteria. Recent advances have revealed that bacteria are not limited to communication within their own species but are capable of 'listening in' and 'broadcasting to' unrelated species to intercept messages and coerce cohabitants into behavioural modifications, either for the good of the population or for the benefit of one species over another. It is also evident that QS is not limited to the bacterial kingdom. The study of two-way intercellular signalling networks between bacteria and both uni- and multicellular eukaryotes as well as between eukaryotes is just beginning to unveil a rich diversity of communication pathways.
Atkinson
Steve
S
Centre for Biomolecular Sciences, School of Molecular Medical Sciences, University of Nottingham, Nottingham NG7 2RD, UK. steve.atkinson@nottingham.ac.uk
Williams
Paul
P
D018407:Bacterial Physiological Phenomena; D056890:Eukaryota / Q000502:physiology*; D015964:Gene Expression Regulation, Bacterial; D054884:Host-Pathogen Interactions / Q000502:physiology; D056265:Microbial Interactions / Q000502:physiology*; D015394:Molecular Structure; D011156:Population Density; D021382:Protein Sorting Signals; D053038:Quorum Sensing / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D013045:Species Specificity
D021382:Protein Sorting Signals
Nat Rev Microbiol. 2008 Aug;6(8):635-43
18536728
Curr Opin Biotechnol. 2006 Jun;17(3):268-73
16650977
Mol Plant Microbe Interact. 1998 Nov;11(11):1119-29
9805399
Infect Immun. 2004 Nov;72(11):6463-70
15501777
Science. 1996 Jun 14;272(5268):1655-8
8658141
Science. 2001 May 11;292(5519):1115-8
11352068
Mol Microbiol. 1997 May;24(3):555-66
9179849
Mol Microbiol. 1998 Apr;28(1):193-203
9593307
Mol Microbiol. 2004 Dec;54(5):1212-23
15554963
J Biol Chem. 2005 May 20;280(20):19563-8
15790567
Mol Microbiol. 2000 Dec;38(5):986-1003
11123673
Microbiology (Reading). 2002 Apr;148(Pt 4):909-922
11932438
Periodontol 2000. 2006;42:47-79
16930306
Bioorg Med Chem Lett. 2003 Aug 4;13(15):2449-53
12852941
J Bacteriol. 2006 Jan;188(2):784-8
16385067
Bioorg Med Chem Lett. 2009 Jul 15;19(14):3941-4
19394822
Mol Microbiol. 2004 Feb;51(3):903-12
14731288
FEMS Microbiol Rev. 2005 Nov;29(5):935-47
16219513
Curr Top Microbiol Immunol. 1994;192:29-41
7859511
Int J Med Microbiol. 2006 Apr;296(2-3):111-6
16503197
J Bacteriol. 2001 Jun;183(12):3537-47
11371516
Cancer Res. 1996 Jul 15;56(14):3207-10
8764108
Cell Host Microbe. 2007 Jun 14;1(4):248-9
18005705
J Bacteriol. 1997 Sep;179(17):5271-81
9286976
Microbiology (Reading). 2000 Oct;146 ( Pt 10):2469-2480
11021923
Biochemistry. 2006 Oct 31;45(43):12929-41
17059210
Eur J Clin Microbiol Infect Dis. 2002 Nov;21(11):767-74
12461585
J Mass Spectrom. 2007 Apr;42(4):490-6
17295415
Mol Microbiol. 2004 Sep;53(6):1563-71
15341639
J Bacteriol. 2008 Jan;190(2):743-6
17933897
Infect Immun. 2005 Jun;73(6):3197-209
15908344
Philos Trans R Soc Lond B Biol Sci. 2007 Jul 29;362(1483):1223--33
17360272
Curr Issues Mol Biol. 2006 Jan;8(1):1-10
16450882
Mol Microbiol. 2008 Jul;69(1):137-51
18466299
Microbiology (Reading). 2006 Apr;152(Pt 4):895-904
16549654
Nat Rev Mol Cell Biol. 2002 Sep;3(9):685-95
12209128
FEMS Immunol Med Microbiol. 2004 Jan 15;40(1):1-9
14734180
Science. 2008 Jul 11;321(5886):259-63
18566250
J Bacteriol. 1999 Sep;181(18):5766-70
10482519
Nature. 1961 Apr 8;190:190
13789858
Mol Microbiol. 2001 Jul;41(2):503-12
11489134
Mol Microbiol. 2001 Jul;41(2):463-76
11489131
Mol Microbiol. 2004 May;52(4):933-45
15130116
Science. 2002 Nov 8;298(5596):1207
12424372
Philos Trans R Soc Lond B Biol Sci. 2007 Jul 29;362(1483):1201-11
17360274
J Bacteriol. 2007 Jul;189(14):5034-40
17496085
J Biochem. 1983 Sep;94(3):777-83
6358202
J Bacteriol. 2006 May;188(9):3365-70
16621831
Org Biomol Chem. 2005 Jan 21;3(2):253-62
15632967
Curr Opin Microbiol. 2009 Apr;12(2):182-91
19249239
Int J Med Microbiol. 2006 Apr;296(2-3):163-70
16503195
Dis Aquat Organ. 2005 Jun 14;65(1):43-52
16042042
Mol Cell. 2004 Sep 10;15(5):677-87
15350213
J Biol Chem. 2000 Mar 17;275(11):7713-22
10713083
Mol Microbiol. 2003 Nov;50(4):1411-27
14622426
Nat Rev Microbiol. 2007 Mar;5(3):230-9
17304251
Microbiology (Reading). 2007 Dec;153(Pt 12):3923-3938
18048907
Clin Exp Metastasis. 2009;26(1):67-76
18516689
J Bacteriol. 2006 Nov;188(21):7686-8
16936013
Dev Cell. 2003 Oct;5(4):647-56
14536065
Nature. 2007 Dec 6;450(7171):883-6
18004304
Nature. 1965 Oct 9;208(5006):155-9
5884251
Chem Biol. 2007 Oct;14(10):1119-27
17961824
J Bacteriol. 1962 Sep;84:546-51
13932286
Cell. 2002 Aug 9;110(3):303-14
12176318
Can J Microbiol. 1966 Aug;12(4):763-70
6007992
Int J Med Microbiol. 2006 Apr;296(2-3):61-71
16487746
Annu Rev Microbiol. 1996;50:727-51
8905097
Cancer Res. 2005 Jul 1;65(13):5917-24
15994970
Med Res Rev. 2009 Jan;29(1):65-124
18956421
Acta Diabetol. 2005 Oct;42(3):119-22
16258734
Mol Microbiol. 1999 Sep;33(6):1267-77
10510240
J Bacteriol. 2006 May;188(9):3169-71
16621807
J Bacteriol. 2006 Aug;188(16):5668-81
16885435
Environ Microbiol. 2005 Feb;7(2):229-40
15658990
J Med Chem. 2003 Jan 2;46(1):97-104
12502363
Microbiology (Reading). 2001 Dec;147(Pt 12):3249-62
11739757
J Bacteriol. 2007 Jul;189(13):4964-8
17468254
FEMS Microbiol Lett. 2007 Jan;266(1):1-9
17233715
Biochem J. 1992 Dec 15;288 ( Pt 3):997-1004
1335238
J Bacteriol. 2006 Feb;188(4):1451-61
16452428
Curr Opin Microbiol. 1999 Dec;2(6):582-7
10607620
Appl Environ Microbiol. 2007 May;73(10):3225-31
17351095
Annu Rev Cell Dev Biol. 2005;21:319-46
16212498
N Engl J Med. 1989 Jul 6;321(1):16-24
2659991
Cell. 2004 Jul 9;118(1):69-82
15242645
Cancer Biol Ther. 2003 Jul-Aug;2(4):364-9
14508106
FEMS Microbiol Rev. 2008 Aug;32(5):842-57
18557946
Chem Biol. 2007 Jan;14(1):87-96
17254955
Br J Pharmacol. 2001 Aug;133(7):1047-54
11487515
Annu Rev Genet. 2008;42:541-64
18713030
Am J Physiol Cell Physiol. 2006 Apr;290(4):C1018-30
16306130
J Bacteriol. 2003 Feb;185(4):1357-66
12562806
Nat Rev Microbiol. 2004 Jul;2(7):581-92
15197393
Mol Microbiol. 2003 Dec;50(5):1477-91
14651632
Mol Cell. 2005 May 27;18(5):507-18
15916958
ACS Chem Biol. 2007 May 22;2(5):315-9
17480049
Curr Opin Plant Biol. 2004 Aug;7(4):429-33
15231266
Curr Opin Microbiol. 2003 Apr;6(2):191-7
12732311
Appl Environ Microbiol. 2006 Jul;72(7):5135-7
16820523
Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1218-23
9990004
Mol Cell. 2008 Oct 10;32(1):150-8
18851841
Environ Microbiol. 2004 Apr;6(4):424-33
15008819
Nucleic Acids Res. 1993 Apr 25;21(8):1747-52
8493092
J Bacteriol. 2005 Jan;187(1):238-48
15601708
Appl Environ Microbiol. 2007 Jan;73(2):650-4
17098922
BMC Microbiol. 2008 Sep 20;8:154
18803868
Dokl Akad Nauk SSSR. 1967 Nov-Dec;177(1):232-5
5622968
Nature. 2008 May 29;453(7195):620-5
18509436
Mol Microbiol. 2003 Oct;50(1):101-4
14507367
PLoS Pathog. 2008 Apr 25;4(4):e1000052
18437240
ACS Chem Biol. 2007 May 22;2(5):293-5
17518429
Curr Opin Chem Biol. 2003 Oct;7(5):586-91
14580562
J Bacteriol. 1970 Oct;104(1):313-22
5473898
Mol Microbiol. 2001 Apr;40(2):414-21
11309123
Lancet Infect Dis. 2002 Nov;2(11):667-76
12409047
Peptides. 2001 Oct;22(10):1519-27
11587781
Mol Microbiol. 2005 Sep;57(6):1734-49
16135237
Appl Environ Microbiol. 2001 Jul;67(7):2982-92
11425711
Anal Bioanal Chem. 2007 Jan;387(2):497-511
16967185
J Bacteriol. 2006 Jul;188(14):5273-85
16816200
Cancer Res. 1958 May;18(4):478-84
13537000
J Infect Dis. 2004 Aug 15;190(4):783-92
15272407
Cell Host Microbe. 2007 Jun 14;1(4):299-308
18005709
Infect Immun. 2001 Nov;69(11):7074-82
11598083
Proc Natl Acad Sci U S A. 2006 Nov 7;103(45):16948-52
17075036
Annu Rev Microbiol. 2007;61:401-22
17506679
Mol Plant Microbe Interact. 2008 Sep;21(9):1184-92
18700823
J Bacteriol. 1997 Jun;179(12):4043-5
9190823
Mol Plant Pathol. 2007 Jul;8(4):529-38
20507519
Anal Bioanal Chem. 2007 Jan;387(2):425-35
16912860
J Bacteriol. 2006 Dec;188(23):8321-6
16980448
Mol Microbiol. 2006 Jan;59(2):610-22
16390454
Infect Immun. 2006 Feb;74(2):910-9
16428734
J Bacteriol. 2009 Mar;191(5):1393-403
19074399
Proc Natl Acad Sci U S A. 1999 Nov 23;96(24):14043-8
10570195
Mol Microbiol. 2009 Mar;71(5):1177-89
19154329
Microbiology (Reading). 1997 Dec;143 ( Pt 12):3703-3711
9421896
Nature. 2008 Jul 31;454(7204):595-9
18563084
Science. 2009 Jan 30;323(5914):614-7
19179525
Clin Infect Dis. 1994 Oct;19(4):655-61; quiz 662-3
7803628
J Bacteriol. 2001 Oct;183(19):5733-42
11544237
Philos Trans R Soc Lond B Biol Sci. 2007 Jul 29;362(1483):1241-9
17360270
Br J Biomed Sci. 2006;63(1):5-11
16613134
Environ Health Perspect. 2004 May;112(6):648-53
15121505
J Bacteriol. 2008 Jan;190(2):769-71
18024511
Nat Rev Microbiol. 2006 Apr;4(4):249-58
16501584
Nat Rev Microbiol. 2005 May;3(5):383-96
15864263
Philos Trans R Soc Lond B Biol Sci. 2007 Jul 29;362(1483):1119-34
17360280
Mol Microbiol. 2007 Aug;65(4):896-906
17640272
Mol Microbiol. 2006 Jan;59(2):602-9
16390453
J Med Chem. 2009 Mar 26;52(6):1569-75
19260689
Mol Microbiol. 2001 Nov;42(3):777-93
11722742
Chem Biol. 2008 Nov 24;15(11):1141-7
19022174
J Am Chem Soc. 2006 Mar 8;128(9):2802-3
16506750
PLoS Pathog. 2008 Oct;4(10):e1000184
18949036
J Pharmacol Exp Ther. 2005 Feb;312(2):417-23
15528454
ISME J. 2008 Jan;2(1):27-36
18049456
Infect Immun. 2003 Nov;71(11):6624-6
14573686
Adv Microb Physiol. 2001;45:199-270
11450110
Appl Environ Microbiol. 2006 Jun;72(6):3805-13
16751484
FEMS Microbiol Lett. 2004 Dec 1;241(1):109-17
15556717
Proc Natl Acad Sci U S A. 2006 Mar 7;103(10):3828-33
16537456
Philos Trans R Soc Lond B Biol Sci. 2007 Jul 29;362(1483):1149-63
17360278
Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):8951-6
12847292
Proc Natl Acad Sci U S A. 2006 Apr 25;103(17):6712-7
16611728
J Bacteriol. 2004 Oct;186(20):6902-14
15466044
Org Biomol Chem. 2004 Nov 21;2(22):3329-36
15534711
Nat Med. 2003 Sep;9(9):1118-9
12949525
PLoS Pathog. 2008 Sep 26;4(9):e1000166
18818733
Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):10995-1000
12960398
Mol Microbiol. 1995 Jul;17(2):345-56
7494483
FEMS Microbiol Rev. 2005 Sep;29(4):813-35
16102604
Gene. 1992 Jul 1;116(1):87-91
1628848
J Bacteriol. 2004 Jun;186(12):3794-805
15175293
Trends Microbiol. 2002 Aug;10(8):365-70
12160634
FEMS Microbiol Lett. 1998 Jun 15;163(2):185-92
9673021
Proc Natl Acad Sci U S A. 1999 Apr 27;96(9):4832-7
10220379
J Bacteriol. 2008 Jul;190(13):4408-15
18178738
FEMS Microbiol Lett. 2006 Mar;256(1):83-9
16487323
Curr Opin Microbiol. 2002 Apr;5(2):216-22
11934621
Philos Trans R Soc Lond B Biol Sci. 2007 Jul 29;362(1483):1135-48
17360279
Curr Opin Gastroenterol. 2007 Jan;23(1):10-5
17133078
Methods Enzymol. 1999;310:43-55
10547781
J Med Chem. 2004 Sep 9;47(19):4633-41
15341477
Nat Rev Microbiol. 2008 Feb;6(2):111-20
18197168
Clin Microbiol Rev. 1996 Oct;9(4):499-511
8894349
Philos Trans R Soc Lond B Biol Sci. 2007 Jul 29;362(1483):1165-83
17360277