title: Effect of perioperative blood transfusion on clinical outcomes in hepatic surgery for cancer.
abstract: Allogeneic blood transfusion during liver resection for malignancies has been associated with an increased incidence of different types of complications: infectious complications, tumor recurrence, decreased survival. Even if there is clear evidence of transfusion-induced immunosuppression, it is difficult to demonstrate that transfusion is the only determinant factor that decisively affects the outcome. In any case there are several motivations to reduce the practice of blood transfusion. The advantages and drawbacks of different transfusion alternatives are reviewed here, emphasizing that surgeons and anesthetists who practice in centers with a high volume of liver resections, should be familiar with all the possible alternatives.
authors.forename: Gianlorenzo
authors.initials: G
authors.lastname: Dionigi
authors.forename: Luigi
authors.initials: L
authors.lastname: Boni
authors.forename: Francesca
authors.initials: F
authors.lastname: Rovera
authors.forename: Stefano
authors.initials: S
authors.lastname: Rausei
authors.forename: Salvatore
authors.initials: S
authors.lastname: Cuffari
authors.forename: Giovanni
authors.initials: G
authors.lastname: Cantone
authors.forename: Alessandro
authors.initials: A
authors.lastname: Bacuzzi
authors.forename: Renzo
authors.initials: R
authors.lastname: Dionigi
mesh_terms: D001803:Blood Transfusion / Q000379:methods*; D001804:Blood Transfusion, Autologous / Q000379:methods*; D006528:Carcinoma, Hepatocellular; D006801:Humans; D015994:Incidence; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000601:surgery*; D008495:Medical Oncology / Q000379:methods; D011183:Postoperative Complications; D012307:Risk Factors; D065227:Transfusion Reaction; D016896:Treatment Outcome
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