title: Bacterial quorum-sensing network architectures.
abstract: Quorum sensing is a cell-cell communication process in which bacteria use the production and detection of extracellular chemicals called autoinducers to monitor cell population density. Quorum sensing allows bacteria to synchronize the gene expression of the group, and thus act in unison. Here, we review the mechanisms involved in quorum sensing with a focus on the Vibrio harveyi and Vibrio cholerae quorum-sensing systems. We discuss the differences between these two quorum-sensing systems and the differences between them and other paradigmatic bacterial signal transduction systems. We argue that the Vibrio quorum-sensing systems are optimally designed to precisely translate extracellular autoinducer information into internal changes in gene expression. We describe how studies of the V. harveyi and V. cholerae quorum-sensing systems have revealed some of the fundamental mechanisms underpinning the evolution of collective behaviors.
authors.affiliation: Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544-1014, USA.
authors.forename: Wai-Leung
authors.initials: WL
authors.lastname: Ng
authors.forename: Bonnie L
authors.initials: BL
authors.lastname: Bassler
mesh_terms: D015964:Gene Expression Regulation, Bacterial; D053038:Quorum Sensing; D014733:Vibrio / Q000378:metabolism; D014734:Vibrio cholerae / Q000378:metabolism
references.citation: J Biol Chem. 2008 Jun 27;283(26):18113-23
references.pmid: 18411263
references.citation: Mol Microbiol. 1996 Aug;21(4):853-62
references.pmid: 8878046
references.citation: Mol Microbiol. 1994 May;12(3):403-12
references.pmid: 8065259
references.citation: J Bacteriol. 2004 Oct;186(20):6902-14
references.pmid: 15466044
references.citation: FEMS Microbiol Lett. 2004 Jan 15;230(1):27-34
references.pmid: 14734162
references.citation: J Bacteriol. 1985 Sep;163(3):1210-4
references.pmid: 3897188
references.citation: Science. 1996 Jun 14;272(5268):1655-8
references.pmid: 8658141
references.citation: Nat Rev Microbiol. 2006 Aug;4(8):597-607
references.pmid: 16845430
references.citation: Nature. 2002 Jan 31;415(6871):545-9
references.pmid: 11823863
references.citation: Proc Natl Acad Sci U S A. 1995 Nov 21;92(24):11140-4
references.pmid: 7479953
references.citation: J Bacteriol. 2003 Oct;185(19):5665-72
references.pmid: 13129937
references.citation: Annu Rev Genet. 2001;35:439-68
references.pmid: 11700290
references.citation: Proc Natl Acad Sci U S A. 1995 Feb 28;92(5):1490-4
references.pmid: 7878006
references.citation: J Bacteriol. 2001 Jun;183(12):3537-47
references.pmid: 11371516
references.citation: Mol Microbiol. 2003 Oct;50(1):319-31
references.pmid: 14507383
references.citation: Genes Dev. 2007 Jan 15;21(2):221-33
references.pmid: 17234887
references.citation: Mol Microbiol. 2002 Jun;44(6):1625-35
references.pmid: 12067349
references.citation: J Mol Microbiol Biotechnol. 1999 Aug;1(1):5-12
references.pmid: 10941779
references.citation: Genes Dev. 2006 Oct 1;20(19):2754-67
references.pmid: 17015436
references.citation: FEMS Microbiol Rev. 2009 Jan;33(1):206-24
references.pmid: 19067751
references.citation: Lett Appl Microbiol. 2006 Aug;43(2):119-24
references.pmid: 16869892
references.citation: Genes Dev. 1996 Aug 15;10(16):2014-24
references.pmid: 8769645
references.citation: J Bacteriol. 2003 Jan;185(1):349-58
references.pmid: 12486073
references.citation: Proc Natl Acad Sci U S A. 2004 Nov 16;101(46):16168-73
references.pmid: 15528279
references.citation: Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1507-12
references.pmid: 11171981
references.citation: Mol Microbiol. 1993 Aug;9(4):773-86
references.pmid: 8231809
references.citation: EMBO J. 2003 Feb 17;22(4):870-81
references.pmid: 12574123
references.citation: Cell. 2009 Feb 20;136(4):615-28
references.pmid: 19239884
references.citation: J Biol Chem. 2007 May 4;282(18):13592-600
references.pmid: 17363368
references.citation: J Bacteriol. 2004 Jun;186(12):3873-81
references.pmid: 15175301
references.citation: J Bacteriol. 1999 Sep;181(18):5766-70
references.pmid: 10482519
references.citation: Mol Microbiol. 2008 Nov;70(4):896-907
references.pmid: 18808382
references.citation: J Biol Chem. 1989 Dec 25;264(36):21670-6
references.pmid: 2600086
references.citation: Mol Microbiol. 2001 Jul;41(2):463-76
references.pmid: 11489131
references.citation: Mol Microbiol. 2008 Oct;70(1):76-88
references.pmid: 18681939
references.citation: Cell. 2006 Sep 22;126(6):1095-108
references.pmid: 16990134
references.citation: Mol Microbiol. 1994 Jul;13(2):273-86
references.pmid: 7984107
references.citation: J Mol Biol. 2002 Nov 8;323(5):785-93
references.pmid: 12417193
references.citation: Cell. 1983 Mar;32(3):773-81
references.pmid: 6831560
references.citation: J Bacteriol. 2008 Nov;190(21):7232-40
references.pmid: 18757542
references.citation: J Bacteriol. 1993 Nov;175(21):7024-32
references.pmid: 8226644
references.citation: Science. 1993 Mar 19;259(5102):1717-23
references.pmid: 8456299
references.citation: J Bacteriol. 2005 May;187(9):3013-9
references.pmid: 15838027
references.citation: J Bacteriol. 1996 Feb;178(4):971-6
references.pmid: 8576070
references.citation: J Bacteriol. 2000 Nov;182(21):6192-202
references.pmid: 11029442
references.citation: Proc Natl Acad Sci U S A. 1991 Dec 15;88(24):11057-61
references.pmid: 1662380
references.citation: Annu Rev Microbiol. 1996;50:591-624
references.pmid: 8905092
references.citation: Mol Microbiol. 2006 Jun;60(6):1446-56
references.pmid: 16796680
references.citation: J Biol Chem. 2008 Apr 4;283(14):8930-8
references.pmid: 18222919
references.citation: Trends Microbiol. 2005 Jan;13(1):27-33
references.pmid: 15639629
references.citation: Mol Cell. 2004 Sep 10;15(5):677-87
references.pmid: 15350213
references.citation: Proc Natl Acad Sci U S A. 1995 Sep 26;92(20):9427-31
references.pmid: 7568146
references.citation: Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1639-44
references.pmid: 9990077
references.citation: Proc Natl Acad Sci U S A. 2007 Oct 2;104(40):15876-81
references.pmid: 17898171
references.citation: Dev Cell. 2003 Oct;5(4):647-56
references.pmid: 14536065
references.citation: Nature. 2007 Dec 6;450(7171):883-6
references.pmid: 18004304
references.citation: Microbiol Mol Biol Rev. 1998 Dec;62(4):1301-14
references.pmid: 9841673
references.citation: Annu Rev Microbiol. 2004;58:303-28
references.pmid: 15487940
references.citation: Mol Cell. 2002 Mar;9(3):685-94
references.pmid: 11931774
references.citation: Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9505-9
references.pmid: 8790360
references.citation: Cell. 2002 Aug 9;110(3):303-14
references.pmid: 12176318
references.citation: Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):3129-34
references.pmid: 11854465
references.citation: Int J Med Microbiol. 2006 Apr;296(2-3):61-71
references.pmid: 16487746
references.citation: Proc Natl Acad Sci U S A. 2007 Jul 3;104(27):11145-9
references.pmid: 17556542
references.citation: Mol Microbiol. 1996 Sep;21(6):1137-46
references.pmid: 8898383
references.citation: Cell. 1994 Apr 22;77(2):207-16
references.pmid: 8168130
references.citation: Microbiol Rev. 1991 Mar;55(1):123-42
references.pmid: 2030669
references.citation: J Bacteriol. 2005 Jul;187(13):4372-80
references.pmid: 15968046
references.citation: ISME J. 2008 Apr;2(4):345-9
references.pmid: 18273067
references.citation: Mol Cell. 2010 Feb 26;37(4):567-79
references.pmid: 20188674
references.citation: Annu Rev Cell Dev Biol. 2005;21:319-46
references.pmid: 16212498
references.citation: J Bacteriol. 2000 May;182(10):2811-22
references.pmid: 10781550
references.citation: Proc Natl Acad Sci U S A. 2009 Jan 27;106(4):1216-21
references.pmid: 19147840
references.citation: Cell. 2004 Jul 9;118(1):69-82
references.pmid: 15242645
references.citation: J Bacteriol. 1997 May;179(10):3127-32
references.pmid: 9150205
references.citation: J Bacteriol. 2002 Mar;184(6):1617-29
references.pmid: 11872713
references.citation: Mol Microbiol. 2007 Feb;63(3):859-71
references.pmid: 17181781
references.citation: J Bacteriol. 1995 Sep;177(17):5000-8
references.pmid: 7665477
references.citation: Annu Rev Genet. 2008;42:541-64
references.pmid: 18713030
references.citation: Cell. 1997 Jun 13;89(6):917-25
references.pmid: 9200610
references.citation: EMBO J. 2009 Feb 18;28(4):429-39
references.pmid: 19165149
references.citation: Microbiology (Reading). 2003 Nov;149(Pt 11):3073-3081
references.pmid: 14600219
references.citation: J Bacteriol. 2004 Feb;186(3):631-7
references.pmid: 14729687
references.citation: Mol Microbiol. 2004 Aug;53(4):1135-46
references.pmid: 15306017
references.citation: Curr Biol. 2009 Feb 24;19(4):341-5
references.pmid: 19230668
references.citation: Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11229-34
references.pmid: 10500159
references.citation: Proc Natl Acad Sci U S A. 2004 Nov 9;101(45):15833-9
references.pmid: 15505212
references.citation: Mol Microbiol. 1997 Dec;26(5):1023-34
references.pmid: 9426139
references.citation: Mol Cell. 2005 May 27;18(5):507-18
references.pmid: 15916958
references.citation: Proc Natl Acad Sci U S A. 1984 Jul;81(13):4154-8
references.pmid: 6377310
references.citation: J Bacteriol. 1994 May;176(10):2796-806
references.pmid: 8188582
references.citation: Curr Opin Microbiol. 2003 Apr;6(2):191-7
references.pmid: 12732311
references.citation: Mol Microbiol. 2000 May;36(4):940-54
references.pmid: 10844680
references.citation: Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1218-23
references.pmid: 9990004
references.citation: Science. 2005 Dec 16;310(5755):1824-7
references.pmid: 16357262
references.citation: J Bacteriol. 2007 Apr;189(7):2945-8
references.pmid: 17259316
references.citation: Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1786-91
references.pmid: 16446460
references.citation: Mol Microbiol. 2003 Oct;50(2):623-33
references.pmid: 14617184
references.citation: J Bacteriol. 1999 Aug;181(16):5004-16
references.pmid: 10438773
references.citation: Nature. 2002 Jun 27;417(6892):971-4
references.pmid: 12087407
references.citation: Mol Microbiol. 2003 Oct;50(1):101-4
references.pmid: 14507367
references.citation: Dev Cell. 2003 Feb;4(2):253-63
references.pmid: 12586068
references.citation: Mol Microbiol. 1999 Jan;31(2):665-77
references.pmid: 10027982
references.citation: Nature. 1993 Apr 1;362(6419):448-50
references.pmid: 8464476
references.citation: Genes Dev. 1995 Mar 1;9(5):547-58
references.pmid: 7698645
references.citation: EMBO J. 2002 Sep 2;21(17):4393-401
references.pmid: 12198141
references.citation: PLoS Biol. 2008 Jan;6(1):e14
references.pmid: 18232735
references.citation: J Bacteriol. 1995 Feb;177(3):654-9
references.pmid: 7836299
references.citation: Nature. 2004 Mar 25;428(6981):437-41
references.pmid: 15042093
references.citation: PLoS Pathog. 2007 Jun;3(6):e81
references.pmid: 17559304
references.citation: Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15623-8
references.pmid: 16230637
references.citation: Proc Natl Acad Sci U S A. 1994 Jan 4;91(1):197-201
references.pmid: 8278364
references.citation: J Biol Chem. 2002 Feb 22;277(8):6247-53
references.pmid: 11733525
references.citation: J Bacteriol. 2000 Nov;182(22):6517-22
references.pmid: 11053400
references.citation: J Clin Invest. 2003 Nov;112(9):1291-9
references.pmid: 14597753
references.citation: J Bacteriol. 2003 Dec;185(23):7001-7
references.pmid: 14617666
references.citation: Proc Natl Acad Sci U S A. 1995 Dec 19;92(26):12055-9
references.pmid: 8618843
references.citation: Nature. 2008 Jul 31;454(7204):595-9
references.pmid: 18563084
references.citation: J Biol Chem. 2008 Aug 29;283(35):23610-8
references.pmid: 18579523
references.citation: Nat Rev Microbiol. 2005 May;3(5):383-96
references.pmid: 15864263
references.citation: Philos Trans R Soc Lond B Biol Sci. 2007 Jul 29;362(1483):1119-34
references.pmid: 17360280
references.citation: J Bacteriol. 2008 Jan;190(1):401-15
references.pmid: 17981981
references.citation: Science. 1997 Jun 27;276(5321):2027-30
references.pmid: 9197262
references.citation: Science. 1993 May 21;260(5111):1127-30
references.pmid: 8493556
references.citation: J Bacteriol. 2008 Nov;190(22):7532-47
references.pmid: 18805977
references.citation: Genes Dev. 2008 Jan 15;22(2):226-38
references.pmid: 18198339
references.citation: Cell. 2008 Aug 8;134(3):461-73
references.pmid: 18692469
references.citation: Proc Natl Acad Sci U S A. 1994 Dec 20;91(26):12619-23
references.pmid: 7809088
references.citation: J Bacteriol. 2005 May;187(9):3052-61
references.pmid: 15838032
references.citation: Mol Microbiol. 2004 Jun;52(6):1677-89
references.pmid: 15186417
references.citation: Cell Microbiol. 2007 Dec;9(12):2903-20
references.pmid: 17614967
references.citation: Mol Microbiol. 2002 Jul;45(1):131-43
references.pmid: 12100554
references.citation: J Bacteriol. 1997 Jun;179(12):3928-35
references.pmid: 9190808
references.citation: Proc Natl Acad Sci U S A. 1994 May 24;91(11):4639-43
references.pmid: 8197112
references.citation: J Bacteriol. 2004 Jun;186(12):3794-805
references.pmid: 15175293
references.citation: Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7687-92
references.pmid: 9636211
references.citation: Nature. 2007 Nov 15;450(7168):411-4
references.pmid: 18004383
references.citation: J Mol Biol. 2006 Jan 13;355(2):262-73
references.pmid: 16307757
references.citation: J Mol Biol. 2008 Aug 29;381(2):300-9
references.pmid: 18582472
references.citation: Biochemistry. 2002 Aug 6;41(31):10095-104
references.pmid: 12146974
references.citation: Mol Microbiol. 2000 Jan;35(1):139-49
references.pmid: 10632884
references.citation: Proc Natl Acad Sci U S A. 1999 Apr 27;96(9):4832-7
references.pmid: 10220379
references.citation: J Bacteriol. 1995 Dec;177(23):6946-51
references.pmid: 7592489
references.citation: Mol Microbiol. 1996 Apr;20(2):415-25
references.pmid: 8733239
references.citation: PLoS Biol. 2009 Mar 24;7(3):e68
references.pmid: 19320539