Parents' interest in predictive genetic testing for their children when a disease has no treatment.
OBJECTIVE
The goal was to measure parents' interest in obtaining predictive genetic testing for their children for a disease that has no treatment.


METHODS
We conducted a nationally representative, Internet-based survey of parents. Parents received 2 vignettes describing hypothetical diseases without treatments. The first vignette described a disease in which symptoms were severe and timing of symptom onset was uncertain. The second vignette described a disease in which both symptom severity and timing of symptom onset were uncertain. Parents reported their interest in predictive genetic testing for their youngest child in each vignette by using a 5-point Likert scale. We collected information on parents' demographic features and parents' general opinions about genetic testing. We conducted logistic regression analyses to evaluate the independent associations between these factors and parents' interest in testing for both vignettes.


RESULTS
The response rate was 71%. For the first vignette, 35% of parents were definitely or probably interested in predictive genetic testing for their youngest child, 35% were unsure, and 31% were definitely or probably not interested. Responses were similar for the second vignette. More than one fourth of parents consistently expressed interest in testing in both vignettes.


CONCLUSIONS
Approximately one third of parents are interested in predictive genetic testing for their children, even for disorders with no treatment. Uncertainty about the severity of symptoms was not related to parents' testing preferences.
Tarini
Beth A
BA
Department of Pediatrics, Child Health Evaluation and Research Unit, Division of General Pediatrics, University of Michigan, Ann Arbor, MI 48109-0456, USA. btarini@umich.edu
Singer
Dianne
D
Clark
Sarah J
SJ
Davis
Matthew M
MM
D000328:Adult; D001294:Attitude to Health; D005260:Female; D005820:Genetic Testing; D006801:Humans; D008297:Male; D010290:Parents / Q000523:psychology