title: The in vitro transport of model thiodipeptide prodrugs designed to target the intestinal oligopeptide transporter, PepT1.
abstract: A thiodipeptide carrier system is shown to be effective at enabling a range of covalently bound molecules, including benzyl, benzoyl and ibuprofen conjugates, to be transported via the intestinal peptide transporter PepT1, demonstrating its potential as a rational drug delivery target.
authors.affiliation: School of Chemistry, University of Manchester, Manchester, M13 9PL, UK.
authors.forename: David
authors.initials: D
authors.lastname: Foley
authors.forename: Myrtani
authors.initials: M
authors.lastname: Pieri
authors.forename: Rachel
authors.initials: R
authors.lastname: Pettecrew
authors.forename: Richard
authors.initials: R
authors.lastname: Price
authors.forename: Steven
authors.initials: S
authors.lastname: Miles
authors.forename: Stephen
authors.initials: S
authors.lastname: Miles
authors.forename: Ho Kam
authors.initials: HK
authors.lastname: Lam
authors.forename: Patrick
authors.initials: P
authors.lastname: Bailey
authors.forename: David
authors.initials: D
authors.lastname: Meredith
mesh_terms: D018938:Caco-2 Cells; D004151:Dipeptides / Q000737:chemistry* / Q000378:metabolism*; D004337:Drug Carriers / Q000737:chemistry / Q000378:metabolism; D015195:Drug Design; D006801:Humans; D007422:Intestines; D000074011:Peptide Transporter 1; D011355:Prodrugs / Q000378:metabolism*; D013455:Sulfur / Q000737:chemistry*; D027981:Symporters / Q000378:metabolism*
chemical_list: D004151:Dipeptides; D004337:Drug Carriers; D000074011:Peptide Transporter 1; D011355:Prodrugs; D027981:Symporters; D013455:Sulfur