A new effective scaffold to facilitate peripheral nerve regeneration: chitosan tube coated with maggot homogenate product.
Recent efforts in scientific research in the field of peripheral nerve regeneration have been directed towards the development of artificial nerve guides. Chitosan tubes applied as a biocompatible and biodegradable bilateral guide for nerve repair is a hot spot in research to date. In previous study, we have found the homogenate product from disinfected maggot larvae can promote wound nerve regeneration and neuropeptides release. Wound nerves belong to the peripheral nerve system. We thus hypothesize that maggot homogenate product use as an external layer outside the chitosan tube will be an effective therapy to facilitate peripheral nerve regeneration.
Zhang
Zhen
Z
Department of Orthopedic Surgery, First Affiliated Hospital, Dalian Medical University, Dalian 116011, Liaoning Province, China.
Wang
Shouyu
S
Tian
Xiliang
X
Zhao
Zexu
Z
Zhang
Jianing
J
Lv
Decheng
D
D000818:Animals; D001369:Axons / Q000502:physiology; D001672:Biocompatible Materials / Q000737:chemistry; D001673:Biodegradation, Environmental; D002448:Cell Adhesion; D048271:Chitosan / Q000737:chemistry*; D006801:Humans; D007814:Larva; D008264:Macrophages / Q000378:metabolism; D008962:Models, Theoretical; D009416:Nerve Regeneration / Q000502:physiology*; D017933:Peripheral Nervous System / Q000473:pathology*; D012583:Schwann Cells / Q000166:cytology; D014945:Wound Healing
D001672:Biocompatible Materials; D048271:Chitosan