Hair as a novel noninvasive method to study the impact of pregnancy on CYP2D6 metabolizing capacity.
A novel method is described to investigate changes in the drug metabolizing capacity of CYP2D6 during pregnancy using hair analysis.
O'Brien
Lisa
L
Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto, Ontario, Canada. lobrien14@gmail.com
Baumer
Carina
C
Thieme
Detlef
D
Sachs
Hans
H
Koren
Gideon
G
D019943:Amino Acid Substitution; D019389:Cytochrome P-450 CYP2D6 / Q000235:genetics* / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D016903:Drug Monitoring; D005260:Female; D020440:Gene Duplication; D005838:Genotype; D006197:Hair / Q000378:metabolism*; D006200:Hair Color / Q000235:genetics*; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate / Q000235:genetics; D016297:Mutagenesis, Site-Directed; D004364:Pharmaceutical Preparations; D010641:Phenotype; D011247:Pregnancy; D011248:Pregnancy Complications; D013379:Substrate Specificity / Q000235:genetics
D004364:Pharmaceutical Preparations; D019389:Cytochrome P-450 CYP2D6