Anti-interleukin-2 receptor antibodies-basiliximab and daclizumab-for the prevention of acute rejection in renal transplantation.
The use of antibody induction after kidney transplantation has increased from 25% to 63% in the past decade and roughly one half of the induction agent used is anti-interleukin-2 receptor antibody (IL-2RA, ie, basiliximab or daclizumab). When combined with calcineurin inhibitor (CNI)-based immunosuppression, IL-2RAs have been shown to reduce the incidence of acute rejection, one of the predictors of poor graft survival, without increasing risks of infections and malignancies in kidney transplantation. For low-immunological-risk patients, IL-2RAs, as compared with lymphocyte-depleting antibodies, are equally efficacious and have better safety profiles. For high-risk patients, however, IL-2RAs may be inferior to lymphocyte-depleting antibodies for the prophylaxis of acute rejection. In an effort to reduce toxicities of other immunosuppressive medications without increasing the risk of acute rejection and chronic graft loss, IL-2RAs have often been combined with steroid- and CNI-sparing immunosuppression protocols. More data support the benefits of early steroid withdrawal with IL-2RA in low-risk patients, but preferred induction therapy for high-risk patients has yet to be determined. Although CNI-sparing protocols with IL-2RA may preserve renal function and improve long-term survival in selected patients, further studies are needed to identify those who benefit most from this strategy.
Sageshima
Junichiro
J
DeWitt Daughtry Family Department of Surgery, Division of Kidney and Pancreas Transplantation, Lillian Jean Kaplan Renal Transplant Center, University of Miami Leonard M. Miller School of Medicine, Miami, FL, USA.
Ciancio
Gaetano
G
Chen
Linda
L
Burke
George W
GW
Transplantation. 2005 Apr 15;79(7):807-14
15818323
Transplantation. 2001 Oct 15;72(7):1261-7
11602853
Nephrol Dial Transplant. 2008 Feb;23(2):707-14
17890244
BMJ. 2003 Apr 12;326(7393):789
12689974
Am J Transplant. 2004 Apr;4(4):626-35
15023156
Transplant Proc. 2002 Aug;34(5):1730-2
12176554
Clin Transplant. 2007 May-Jun;21(3):295-300
17488375
Lancet. 2000 Oct 14;356(9238):1327-8
11073027
Transplantation. 2004 Aug 27;78(4):584-90
15446319
Transplantation. 2005 Aug 27;80(4):457-65
16123718
N Engl J Med. 2007 Dec 20;357(25):2562-75
18094377
Cochrane Database Syst Rev. 2009 Jan 21;(1):CD005632
19160257
Transpl Int. 2000;13(2):151-9
10836653
Clin Transplant. 2008 Mar-Apr;22(2):200-10
18339140
Transplantation. 2005 Dec 27;80(12):1734-41
16378069
Am J Transplant. 2007 Mar;7(3):560-70
17229079
Transplantation. 2005 Feb 15;79(3):344-8
15699766
Transplant Proc. 2004 May;36(4):1080-1
15194375
Transplant Proc. 2001 Feb-Mar;33(1-2):1011-2
11267168
N Engl J Med. 1998 Jan 15;338(3):161-5
9428817
Am J Transplant. 2004 Nov;4(11):1776-85
15476476
Clin Transplant. 2006 May-Jun;20(3):325-9
16824149
Transplant Proc. 2001 Aug;33(5):2767-9
11498153
Am J Kidney Dis. 2008 Jan;51(1 Suppl 1):S1-320
18086389
Transplantation. 2007 Apr 15;83(7):883-92
17460558
Transplantation. 2001 May 15;71(9):1282-7
11397963
Transplant Proc. 1999 Sep;31(6):2206-7
10500546
Clin Transplant. 2000 Oct;14(5):509-13
11048998
Transplantation. 2000 Nov 15;70(9):1352-9
11087152
Transplantation. 1991 Jan;51(1):107-13
1846250
Transplantation. 2004 Jan 27;77(2):166-76
14742976
N Engl J Med. 2005 Aug 25;353(8):770-81
16120857
Transplantation. 1999 Nov 27;68(10):1597-603
10589961
Transplant Proc. 2001 Nov-Dec;33(7-8):3184-6
11750366
Transplantation. 1994 Mar 27;57(6):857-9
8154032
Transplantation. 2001 Sep 15;72(5):845-50
11571448
Transplantation. 2002 Apr 15;73(7):1100-6
11965039
N Engl J Med. 2000 Mar 2;342(9):605-12
10699159
Am J Transplant. 2002 Jul;2(6):568-73
12118902
Transplantation. 2006 Dec 15;82(11):1533-6
17164728
Transpl Int. 2000;13(2):142-5
10836651
Am J Transplant. 2008 Feb;8(2):307-16
18211506
Clin Transplant. 2009 Jan-Feb;23(1):23-32
18798851
N Engl J Med. 2008 Oct 16;359(16):1736-8
18923181
Am J Transplant. 2004 May;4(5):803-10
15084178
Transplantation. 1997 Dec 27;64(12):1701-5
9422405
Clin Transplant. 2003 Aug;17(4):369-76
12868995
Transplant Proc. 2000 Jun;32(4):790-2
10856587
Transpl Int. 2007 Jan;20(1):27-36
17181650
Transplantation. 1989 Jan;47(1):55-9
2643232
Transplant Proc. 2002 Aug;34(5):1617-8
12176508
Transplantation. 1995 Aug 15;60(3):248-52
7645037
Am J Transplant. 2003 Mar;3(3):306-11
12614286
J Am Soc Nephrol. 2000 Oct;11(10):1903-1909
11004222
Lancet. 1997 Oct 25;350(9086):1193-8
9652559
Ann Surg. 2008 Oct;248(4):564-77
18936569
Mol Immunol. 2003 Jul;39(17-18):1083-8
12835081
Transplantation. 2004 Nov 27;78(10):1560-3
15599323
Transplantation. 2004 Nov 15;78(9):1332-40
15548972
Clin Transplant. 2001 Apr;15(2):123-30
11264639
Am J Transplant. 2003 Aug;3(8):1010-6
12859538
Transplant Proc. 2001 Feb-Mar;33(1-2):2032-3
11267613
Transplantation. 2000 Sep 15;70(5):784-90
11003358
Transplantation. 1993 Apr;55(4):752-6; discussion 756-7
8475548
Transplantation. 2007 Jul 15;84(1):75-82
17627241
Transplantation. 2006 Mar 27;81(6):832-9
16570004
Transplantation. 2005 Sep 27;80(6):807-14
16210969
Transplant Proc. 2001 Feb-Mar;33(1-2):1057-8
11267189
Transplantation. 2002 Oct 15;74(7):966-71
12394838
Am J Transplant. 2002 Jan;2(1):48-56
12095056
Transplant Proc. 2003 Mar;35(2):873-4
12644172
Clin Transplant. 2000 Dec;14(6):550-4
11127307
Am J Transplant. 2008 Mar;8(3):574-85
18294153
Am J Transplant. 2005 Aug;5(8):1976-85
15996248
Transplantation. 2001 Dec 27;72(12):1915-9
11773888
Am J Transplant. 2005 Jan;5(1):157-66
15636625
Transplantation. 1999 Nov 15;68(9):1288-94
10573065
Am J Transplant. 2003 Apr;3(4):416-23
12694063
Clin Transplant. 2003 Oct;17(5):428-32
14703925
Transplantation. 1999 Jan 15;67(1):110-5
9921806
Transplantation. 2001 May 15;71(9):1320-8
11397971
Transplantation. 1988 Jan;45(1):226-8
3122385
Transplantation. 1999 Jan 27;67(2):276-84
10075594
Transplantation. 2004 Nov 27;78(10):1548-56
15599321
Transplantation. 2008 Jul 15;86(1):67-74
18622280
Am J Transplant. 2006 May;6(5 Pt 1):1042-8
16611342
Transplantation. 2003 Jan 15;75(1):37-43
12544868
Am J Transplant. 2003 Jan;3(1):50-2
12492710
Transplant Proc. 2001 Feb-Mar;33(1-2):1013-4
11267169
Transplantation. 2001 Sep 15;72(5):839-45
11571447
Transplantation. 2001 Dec 27;72(12 Suppl):S75-80
11833145
Transplant Proc. 2005 Mar;37(2):802-3
15848537
Am J Transplant. 2006 Jul;6(7):1617-23
16827862
Transplantation. 2001 Nov 27;72(10):1709-10
11726840
Am J Transplant. 2005 Oct;5(10):2539-48
16162205
Transplantation. 2004 Aug 27;78(4):557-65
15446315
N Engl J Med. 2006 Nov 9;355(19):1967-77
17093248
Transplantation. 1999 Dec 27;68(12):1865-74
10628766
Transplantation. 1995 Oct 15;60(7):748-56
7570988
CMAJ. 1992 Sep 1;147(5):645-57
1521210
Transplantation. 1997 Jan 15;63(1):33-8
9000657