[C-arm CT for chemo-embolization of liver tumors].
Local efficacy of transarterial chemo-embolization (TACE) is enhanced if selective treatment is performed. Selectivity of TACE mainly depends on vascular anatomy but also on the identification and catheterization of tumor feeding arteries. Correlation of vascular territories and target tumor volume in angiographic projection images is more difficult if tumors are not hypervascularized and contrast of liver parenchyma is inhomogeneous.C-arm CT offers the option of selective perfusion imaging via tumor-feeding arteries. This allows the comparison of perfusion images and baseline cross-sectional imaging to evaluate if tumors are covered completely by local treatment and to change the catheter position if necessary. Furthermore the uptake of embolization material, such as lipiodol can be checked by C-arm CT.In a prospective study of 75 TACE of liver tumors and liver metastases we evaluated the appropriateness of 85 catheter positions ready for delivery by perfusion C-arm CT and compared the diagnostic confidence of angiography and perfusion C-arm CT in terms of judgment of correct catheter position for the planned treatment. Diagnostic confidence was improved by perfusion C-arm CT in 55% of cases and in 11 cases (13%) catheter positions were inappropriate and had to be corrected. The reasons for catheter repositioning were incomplete coverage of the target tumor by perfusion volume (mismatch) in 6 cases, inappropriate perfusion of adjacent liver parenchyma in 2 cases and non-selective tumor perfusion via collateral arteries in 3 cases. C-arm CT allowed sufficient visualization of uptake of lipiodol in all cases evaluated.The diagnostic benefit of C-arm CT increases if tumors are treated more selectively, are not strongly hypervascular, are located centrally and if the enhancement of liver parenchyma is inhomogeneous. C-arm CT causes additional working time and contrast load, which is relatively low compared to angiography. Radiation exposure of 151 microGy per C-arm series necessitates careful and therapy-oriented assessment of indications.
Huppert
P E
PE
Institut für Diagnostische und Interventionelle Radiologie, Klinikum Darmstadt, Grafenstrasse 9, Darmstadt, Germany. Huppert@klinikum-darmstadt.de
Firlbeck
G
G
Meissner
O A
OA
Wietholtz
H
H
D000792:Angiography / Q000379:methods*; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D016461:Chemoembolization, Therapeutic / Q000379:methods*; D006801:Humans; D008113:Liver Neoplasms / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000628:therapy*; D015641:Radiography, Interventional / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000379:methods*
D000970:Antineoplastic Agents
AJR Am J Roentgenol. 2009 Apr;192(4):1057-63
19304714
J Vasc Interv Radiol. 2007 Dec;18(12):1500-7
18057284
J Vasc Interv Radiol. 2009 May;20(5):606-13
19345589
J Vasc Interv Radiol. 2007 Dec;18(12):1508-16
18057285
J Vasc Interv Radiol. 1999 Jun;10(6):811-5
10392953
J Vasc Interv Radiol. 2007 Oct;18(10):1305-9
17911523