Randomized clinical trial comparing whitening strips, paint-on gel and negative control.
OBJECTIVE
To evaluate efficacy and safety of peroxide-containing whitening strips and a paint-on gel relative to a non-peroxide experimental control.


METHODS
After informed consent, 52 healthy adults in Shanghai, China were randomized to one of three treatment groups: 6% hydrogen peroxide whitening strips (Crest Whitestrips), 5.9% hydrogen peroxide paint-on gel (Colgate Simply White), or water rinse which served as a negative experimental control. Strip use was twice daily over 7 days, while the paint-on gel and rinse were used twice daily over 14 days. Efficacy was measured from standard digital images of the maxillary anterior teeth, and safety was assessed from interview and intraoral examination.


RESULTS
Whitening strips provided the greatest end-of-treatment reduction in yellowness (Deltab*), with adjusted means +/- standard errors of -1.72 +/- 0.18 for the strip group, -0.48 +/- 0.10 for the paint-on gel group, and 0.13 +/- 0.09 for the water rinse group. For DeltaL* (lightness), end-of-treatment adjusted means +/- standard errors were 1.88 +/- 0.21 for the strip group, 0.60 +/- 0.15 for the paint-on gel, and -0.10 +/- 0.18 for the negative control. Groups differed significantly (P< 0.007) with respect to Deltab* and DeltaL* at end-of-treatment, as well as other color parameters. All treatments were well-tolerated.
Xu
Xiao
X
School of Medicine, No. 9 People's Hospital, Shanghai Jiao Tong University, Shanghai, China. xuxiao@smmail.cn
Zhu
Lingyi
L
Tang
Yu
Y
Wang
Yi
Y
Zhang
Ken
K
Li
Sarah
S
Bohman
Lisa C
LC
Gerlach
Robert W
RW
D000293:Adolescent; D000328:Adult; D002681:China; D003116:Color; D003481:Cuspid / Q000473:pathology; D005260:Female; D005782:Gels; D006801:Humans; D006861:Hydrogen Peroxide / Q000008:administration & dosage / Q000627:therapeutic use*; D007091:Image Processing, Computer-Assisted / Q000379:methods; D007180:Incisor / Q000473:pathology; D008297:Male; D008437:Maxilla; D008875:Middle Aged; D016877:Oxidants / Q000008:administration & dosage / Q000627:therapeutic use*; D023861:Photography, Dental / Q000379:methods; D011446:Prospective Studies; D012449:Safety; D016037:Single-Blind Method; D013997:Time Factors; D014073:Tooth Bleaching / Q000295:instrumentation / Q000379:methods*; D014075:Tooth Discoloration / Q000473:pathology / Q000628:therapy; D016896:Treatment Outcome; D055815:Young Adult
D005782:Gels; D016877:Oxidants; D006861:Hydrogen Peroxide