The role of nutrients in the prevention and treatment of Alzheimer's disease: methodology for a systematic review.
There is a large body of existing data on nutrition in Alzheimer's disease (AD). We are conducting a systematic review of published scientific literature to determine the role of specific nutrients, both individually and in combination, in the prevention and treatment of AD. This will contribute towards a structured evidence base to help inform the clinical management of AD. The objective of the systematic review is to evaluate the strength of evidence from both observational cohort studies and randomized controlled trials on the role of fats, vitamins, antioxidants and other nutrients in the prevention and treatment of AD. We present here the methodology of our systematic review.
George
D R
DR
Department of Medical Anthropology, University of Oxford, Oxford, UK.
Dangour
A D
AD
Smith
L
L
Ruddick
J
J
Vellas
B
B
Whitehouse
P J
PJ
D000544:Alzheimer Disease / Q000178:diet therapy* / Q000378:metabolism / Q000517:prevention & control*; D000975:Antioxidants / Q000378:metabolism / Q000627:therapeutic use*; D001361:Avitaminosis / Q000150:complications / Q000178:diet therapy / Q000378:metabolism; D015331:Cohort Studies; D004041:Dietary Fats / Q000009:adverse effects / Q000378:metabolism / Q000627:therapeutic use*; D006801:Humans; D044342:Malnutrition / Q000150:complications / Q000178:diet therapy* / Q000378:metabolism; D015201:Meta-Analysis as Topic; D016032:Randomized Controlled Trials as Topic / Q000379:methods / Q000706:statistics & numerical data; D014815:Vitamins / Q000378:metabolism / Q000627:therapeutic use*
D000975:Antioxidants; D004041:Dietary Fats; D014815:Vitamins