title: Two 22S-solanidine-type steroidal alkaloids from Fritillaria anhuiensis.
abstract: Phytochemical investigation of the fresh bulbs of Fritillaria anhuiensis S. C. Chen et S. E. Yin, resulted in the isolation of a known steroidal alkaloid solanidine of (22S,25S)-solanid-5-en-3beta-ol (1), which has never yet been found as a natural substance, and of a new steroidal alkaloid (22S,25S)-solanid-5,20(21)-dien-3beta-ol. Compounds 1 and 2 were the first solanidine-type alkaloids with 22-S configuration discovered from nature. Their structures were elucidated based on spectroscopic analysis, including 1D and 2D NMR experiments.
authors.affiliation: School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, People's Republic of China.
authors.forename: Qing Yao
authors.initials: QY
authors.lastname: Shou
authors.forename: Qing
authors.initials: Q
authors.lastname: Tan
authors.forename: Zheng
authors.initials: Z
authors.lastname: Wu Shen
mesh_terms: D004144:Diosgenin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification; D031410:Fritillaria / Q000737:chemistry*; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry*; D018517:Plant Roots
chemical_list: C550888:(22S,25S)-solanid-5,20(21)-dien-3beta-ol; C550889:(22S,25S)-solanid-5-en-3beta-ol; D010936:Plant Extracts; D004144:Diosgenin; C013255:solanidine