Frequency of PRRS live vaccine virus (European and North American genotype) in vaccinated and non-vaccinated pigs submitted for respiratory tract diagnostics in North-Western Germany.
The frequency of PRRSV corresponding to live vaccines and wild-type was determined in 902 pigs from North-Western Germany submitted for post-mortem examination. Overall, 18.5% of the samples were positive for the EU wild-type virus. EU genotype vaccine virus was detected in 1.3% and the NA genotype vaccine virus in 8.9% of all samples. The detection of the EU vaccine was significantly higher in pigs vaccinated with the corresponding vaccine (OR=9.4). Pigs vaccinated with NA genotype had significantly higher detection chances for the corresponding vaccine virus when compared to non-vaccinated animals (OR=3.34) animals, however, NA vaccine was also frequently detected in non-vaccinated pigs. Concluding, the dynamics of NA genotype vaccine and EU wild-type virus corresponds with studies on PRRSV spread in endemically infected herds. The potential of spontaneous spread of the NA genotype vaccine should be considered in the planning of eradication programs.
grosse Beilage
Elisabeth
E
Field Station for Epidemiology, University of Veterinary Medicine Hannover, Buescheler Str. 9, D-49456 Bakum, Germany. elisabeth.grosse.beilage@tiho-hannover.de
Nathues
Heiko
H
Meemken
Diana
D
Harder
Timm C
TC
Doherr
Marcus G
MG
Grotha
Inga
I
Greiser-Wilke
Irene
I
D000818:Animals; D005838:Genotype; D005858:Germany / Q000453:epidemiology; D016015:Logistic Models; D016017:Odds Ratio; D019318:Porcine Reproductive and Respiratory Syndrome / Q000453:epidemiology / Q000517:prevention & control*; D019316:Porcine respiratory and reproductive syndrome virus / Q000235:genetics* / Q000276:immunology; D013552:Swine; D014765:Viral Vaccines / Q000276:immunology*
D014765:Viral Vaccines
Prev Vet Med. 2002 Feb 14;53(1-2):83-101
11821139
Arch Virol. 2000;145(6):1149-61
10948988
Vet J. 2008 Sep;177(3):345-51
17644436
Transbound Emerg Dis. 2008;55(2):140-3
18397502
Vet Microbiol. 2005 May 20;107(3-4):171-8
15863276
Vet Microbiol. 2008 Feb 5;127(1-2):128-35
17869032
Arch Virol. 1999;144(12):2389-401
10664392
Zentralbl Veterinarmed B. 1995 Jun;42(4):209-15
8546019
Theriogenology. 2006 Aug;66(3):655-62
16730057
J Gen Virol. 2006 Jul;87(Pt 7):1835-1841
16760385
Vet Microbiol. 1997 May;56(1-2):21-32
9228679
Arch Virol. 2006 Nov;151(11):2269-76
16763729
Vet Rec. 1997 Nov 8;141(19):497-9
9402722
J Virol Methods. 2005 Nov;129(2):134-44
15992937
Vet Microbiol. 1998 Nov;64(1):7-22
9874099
Can J Vet Res. 2003 May;67(2):114-20
12760476
Arch Virol. 2008;153(8):1479-88
18592131
J Gen Virol. 1999 Feb;80 ( Pt 2):307-315
10073689
Vet Microbiol. 1999 Aug 31;68(3-4):187-95
10510038
Nucleic Acids Res. 1997 Dec 15;25(24):4876-82
9396791
Virology. 2003 Dec 20;317(2):197-207
14698660