title: Cyclobutane-containing alkaloids: origin, synthesis, and biological activities.
abstract: Present review describes research on novel natural cyclobutane-containing alkaloids isolated from terrestrial and marine species. More than 60 biological active compounds have been confirmed to have antimicrobial, antibacterial, antitumor, and other activities. The structures, synthesis, origins, and biological activities of a selection of cyclobutane-containing alkaloids are reviewed. With the computer program PASS some additional biological activities are also predicted, which point toward new possible applications of these compounds. This review emphasizes the role of cyclobutane-containing alkaloids as an important source of leads for drug discovery.
authors.affiliation: Institute of Biomedical Chemistry, Russian Academy of the Medical Sciences, Moscow 119121, Russia.
authors.forename: Anastasia
authors.initials: A
authors.lastname: Sergeiko
authors.forename: Vladimir V
authors.initials: VV
authors.lastname: Poroikov
authors.forename: Lumir O
authors.initials: LO
authors.lastname: Hanus
authors.forename: Valery M
authors.initials: VM
authors.lastname: Dembitsky
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