Cocoa, chocolate, and cardiovascular disease.
A significant body of evidence demonstrates that diets rich in fruits and vegetables promote health and attenuate, or delay, the onset of various diseases, including cardiovascular disease, diabetes, certain cancers, and several other age-related degenerative disorders. The concept that moderate chocolate consumption could be part of a healthy diet has gained acceptance in past years based on the health benefits ascribed to selected cocoa components. Specifically, cocoa as a plant and chocolate as food contain a series of chemicals that can interact with cell and tissue components, providing protection against the development and amelioration of pathological conditions. The most relevant effects of cocoa and chocolate have been related to cardiovascular disease. The mechanisms behind these effects are still under investigation. However, the maintenance or restoration of vascular NO production and bioavailability and the antioxidant effects are the mechanisms most consistently supported by experimental data. This review will summarize the most recent research on the cardiovascular effects of cocoa flavanols and related compounds.
Galleano
Monica
M
Physical Chemistry-Program of Free Radicals in Biochemistry (PRALIB), School of Pharmacy and Biochemistry, University of Buenos Aires-National Council of Scientific and Technological Research (CONICET), Argentina.
Oteiza
Patricia I
PI
Fraga
Cesar G
CG
D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D002099:Cacao / Q000737:chemistry*; D002318:Cardiovascular Diseases / Q000209:etiology / Q000517:prevention & control*; D005419:Flavonoids / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D016166:Free Radical Scavengers / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000378:metabolism
D000975:Antioxidants; D005419:Flavonoids; D016166:Free Radical Scavengers
J Nutr. 2003 Oct;133(10):3255S-3261S
14519823
Free Radic Biol Med. 2003 Oct 15;35(8):837-44
14556848
Free Radic Biol Med. 2002 Dec 15;33(12):1693-702
12488137
J Nutr. 2008 Oct;138(10):1939-45
18806104
Am J Clin Nutr. 2008 Dec;88(6):1685-96
19064532
J Agric Food Chem. 1999 Oct;47(10):4184-8
10552788
Clin Dev Immunol. 2005 Mar;12(1):11-7
15712594
J Nutr. 2002 Jul;132(7):1825-9
12097654
Br J Pharmacol. 2004 Jun;142(4):671-8
15159281
J Biol Chem. 1998 May 1;273(18):11038-43
9556586
J Nutr. 2006 May;136(5):1150-5
16614396
Free Radic Biol Med. 2004 Nov 1;37(9):1351-9
15454274
Am J Clin Nutr. 2000 Jul;72(1):30-5
10871557
J Cardiovasc Pharmacol. 2007 Feb;49(2):74-80
17312446
Biochem Biophys Res Commun. 2007 Aug 3;359(3):828-33
17560937
FASEB J. 2002 Dec;16(14):1958-60
12397093
Curr Opin Nephrol Hypertens. 2003 Mar;12(2):165-74
12589177
Am J Clin Nutr. 2002 Nov;76(5):1106-10
12399286
JAMA. 1986 Nov 28;256(20):2823-8
3773199
Free Radic Res. 2001 Jan;34(1):93-9
11235000
Am J Physiol. 1996 Oct;271(4 Pt 2):H1626-34
8897960
J Nutr. 2007 Jun;137(6):1436-41
17513403
Biochem Pharmacol. 1983 Sep 15;32(18):2822-5
6684926
Am J Clin Nutr. 2001 Nov;74(5):596-602
11684527
JAMA. 2003 Apr 23-30;289(16):2083-93
12709466
Bioorg Med Chem. 2007 Dec 1;15(23):7408-25
17869117
JAMA. 2003 Aug 27;290(8):1030-1
12941674
J Nutr. 2002 Dec;132(12):3663-7
12468604
Free Radic Biol Med. 1996;20(7):933-56
8743980
Biochem J. 2002 Sep 1;366(Pt 2):531-9
12030847
Am J Clin Nutr. 2002 Oct;76(4):798-804
12324293
Am J Clin Nutr. 2009 Jun;89(6):1784-91
19403635
Eur J Clin Nutr. 2009 Apr;63(4):588-9
17957191
Free Radic Res. 2004 Dec;38(12):1311-20
15763955
Am J Clin Nutr. 2002 Jul;76(1):93-9
12081821
FASEB J. 2006 Jun;20(8):1082-9
16770007
Biochem Biophys Res Commun. 2000 May 27;272(1):236-41
10872833
J Nutr Biochem. 2002 Nov;13(11):645-652
12550061
IUBMB Life. 2007 Apr-May;59(4-5):308-15
17505970
J Agric Food Chem. 2003 Nov 5;51(23):6893-8
14582992
Arch Biochem Biophys. 2008 Jan 15;469(2):209-19
17996190
Am J Clin Nutr. 2003 Jun;77(6):1466-73
12791625
Lancet. 1996 Nov 30;348(9040):1514
8942794
Biochem Biophys Res Commun. 2000 Oct 5;276(3):945-51
11027573
Prev Med. 1992 Jul;21(4):546-53
1409496
Biochem Biophys Res Commun. 2003 Jul 18;307(1):69-73
12849982
Anal Bioanal Chem. 2009 Jul;394(6):1545-56
19333587
J Lipid Res. 2001 May;42(5):725-34
11352979
Br J Nutr. 2009 Apr;101(7):931-40
19126261
J Biol Chem. 2008 Jul 25;283(30):20664-73
18519570
Circulation. 2001 Jun 12;103(23):2792-8
11401934
Nat Struct Mol Biol. 2004 Apr;11(4):380-1
15024383
Circulation. 2001 Jul 10;104(2):151-6
11447078
FEBS Lett. 1998 Nov 27;440(1-2):8-12
9862414
Circulation. 1992 Jun;85(6):2284-90
1591842
Free Radic Res. 2000 Nov;33(5):635-41
11200094
Ann N Y Acad Sci. 2002 May;957:279-83
12074981
Free Radic Biol Med. 2009 May 15;46(10):1319-27
19248828
Nat Rev Cancer. 2003 Oct;3(10):768-80
14570043
J Atheroscler Thromb. 2005;12(1):20-8
15725692
J Nutr. 2004 Jan;134(1):38-42
14704290
Clin Dev Immunol. 2005 Mar;12(1):1-9
15712593
Am J Clin Nutr. 2005 Mar;81(3):611-4
15755830
Free Radic Biol Med. 2003 Jan 1;34(1):84-92
12498983
Free Radic Biol Med. 1998 Feb;24(3):435-41
9438556
Arch Intern Med. 2007 Apr 9;167(7):626-34
17420419
Biochim Biophys Acta. 1992 Jul 29;1127(2):141-6
1643098
J Atheroscler Thromb. 2000;7(3):164-8
11480458
J Nutr. 2003 Mar;133(3):700-6
12612140
Hypertension. 2005 Aug;46(2):398-405
16027246
JAMA. 2007 Jul 4;298(1):49-60
17609490
J Nutr. 1998 Jul;128(7):1172-8
9649602
Adv Exp Med Biol. 2006;583:299-306
17153614
Arch Biochem Biophys. 2008 Aug 15;476(2):186-95
18275839
J Nutr. 2008 Apr;138(4):753-60
18356331
N Engl J Med. 1997 Apr 17;336(16):1117-24
9099655
Arterioscler Thromb Vasc Biol. 2006 Oct;26(10):2186-91
16990564
J Hypertens. 2003 Dec;21(12):2281-6
14654748
J Natl Cancer Inst. 2004 Nov 3;96(21):1577-84
15523086
Cancer Res. 2006 Mar 1;66(5):2500-5
16510563
J Agric Food Chem. 2002 Mar 13;50(6):1700-5
11879061
Biochim Biophys Acta. 1996 Dec 13;1304(3):210-22
8982267
Proc Soc Exp Biol Med. 2000 Oct;225(1):32-8
10998196
Biol Chem. 2001 Dec;382(12):1687-96
11843182
Free Radic Biol Med. 2006 Oct 15;41(8):1247-56
17015171
FEBS Lett. 1997 Dec 1;418(3):291-6
9428730
Biochem Biophys Res Commun. 2006 Jun 23;345(1):508-15
16681998
Biochem Pharmacol. 1987 Mar 1;36(5):717-20
3827953
Biochem J. 1980 Nov 1;191(2):421-7
6263247
FASEB J. 2004 Jan;18(1):167-9
14630700
Thromb Res. 1997 Jan 1;85(1):1-22
8983121
J Nutr Biochem. 2003 Feb;14(2):104-10
12667602
Pharmacol Rev. 2000 Dec;52(4):673-751
11121513
Biochem Biophys Res Commun. 2001 Jul 20;285(3):588-93
11453632
Arch Intern Med. 2006 Feb 27;166(4):411-7
16505260
FEBS Lett. 1975 Jul 1;54(3):311-4
236930
Am J Clin Nutr. 2005 Mar;81(3):541-2
15755820
Free Radic Biol Med. 2007 Apr 1;42(7):955-70
17349924
JAMA. 2003 Aug 27;290(8):1029-30
12941673
J Cardiovasc Pharmacol. 2006;47 Suppl 2:S128-35; discussion S172-6
16794450
J Am Coll Cardiol. 2005 Oct 4;46(7):1276-83
16198843
Arch Biochem Biophys. 2002 Oct 15;406(2):203-8
12361708
Am J Clin Nutr. 2008 Jul;88(1):58-63
18614724
Br J Nutr. 1997 Jul;78(1):41-55
9292758
Am J Clin Nutr. 2001 Jan;73(1):36-40
11124747
Curr Med Chem. 2001 Jun;8(7):797-807
11375750
Circulation. 2004 Sep 28;110(13):1861-7
15364805
J Nutr. 2001 Jun;131(6):1753-7
11385063
Free Radic Res. 2006 Oct;40(10):1086-94
17015253
Lancet. 1993 Oct 23;342(8878):1007-11
8105262
Am J Clin Nutr. 2000 Nov;72(5):1150-5
11063442
Proc Natl Acad Sci U S A. 2004 Mar 23;101(12):4003-8
15020765
N Engl J Med. 1989 Apr 6;320(14):915-24
2648148
Proc Natl Acad Sci U S A. 2006 Jan 24;103(4):1024-9
16418281
J Ethnopharmacol. 2009 Mar 18;122(2):261-7
19330924
Am J Clin Nutr. 2007 Mar;85(3):709-17
17344491
Curr Drug Metab. 2004 Jun;5(3):245-56
15180494
J Agric Food Chem. 2009 Feb 25;57(4):1589-94
19182941
Arch Intern Med. 2004 Jul 26;164(14):1534-40
15277285
N Engl J Med. 1995 Nov 16;333(20):1301-7
7566020
J Nutr. 2000 Aug;130(8S Suppl):2109S-14S
10917931
Mol Nutr Food Res. 2008 Nov;52(11):1340-8
18991246
Free Radic Biol Med. 2002 Jul 1;33(1):142-8
12086692
Clin Dev Immunol. 2005 Mar;12(1):19-25
15712595
J Agric Food Chem. 2005 Jun 15;53(12):5041-8
15941354
Hypertension. 2001 Aug;38(2):159-65
11509469
FEBS Lett. 2000 Jan 14;465(2-3):93-7
10631311
Circulation. 2007 Nov 20;116(21):2376-82
17984375
Lancet. 1992 Jun 20;339(8808):1523-6
1351198
J Nutr. 1999 Sep;129(9):1662-8
10460201
JAMA. 2004 Sep 22;292(12):1433-9
15383513
Biochem Pharmacol. 2003 Mar 1;65(5):773-81
12628491
Heart. 2006 Jan;92(1):119-20
16365364
J Cardiovasc Pharmacol. 2006;47 Suppl 2:S103-9; discussion 119-21
16794446
Free Radic Res. 2008 Oct;42(10):864-72
18946795
J Nutr. 2008 Sep;138(9):1671-6
18716168
Free Radic Biol Med. 2002 Jul 15;33(2):220-35
12106818