title: Management of ascites due to gastrointestinal malignancy.
abstract: Ascites is the pathological accumulation of fluid within the abdominal cavity. The most common cancers associated with ascites are adenocarcinomas of the ovary, breast, colon, stomach and pancreas. Symptoms include abdominal distension, nausea, vomiting, early satiety, dyspnea, lower extremity edema, weight gain and reduced mobility. There are many potential causes of ascites in cancer patients, including peritoneal carcinomatosis, malignant obstruction of draining lymphatics, portal vein thrombosis, elevated portal venous pressure from cirrhosis, congestive heart failure, constrictive pericarditis, nephrotic syndrome and peritoneal infections. Depending on the clinical presentation and expected survival, a diagnostic evaluation is usually indicated as it will impact both prognosis and the treatment approach. Key tests include serum albumin and protein and a simultaneous diagnostic paracentesis, checking ascitic fluid, WBCs, albumin, protein and cytology. Median survival after diagnosis of malignant ascites is in the range of 1 to 4 months; survival is apt to be longer for ovarian and breast cancers if systemic anti-cancer treatments are available.
authors.affiliation: Department of Medical Oncology, Yale University School of Medicine, New Haven, Connecticut, USA. wasif.saif@yale.edu
authors.forename: Muhammad W
authors.initials: MW
authors.lastname: Saif
authors.forename: Imran A P
authors.initials: IA
authors.lastname: Siddiqui
authors.forename: Muhammad A
authors.initials: MA
authors.lastname: Sohail
mesh_terms: D000230:Adenocarcinoma / Q000150:complications* / Q000503:physiopathology / Q000628:therapy; D000818:Animals; D001201:Ascites / Q000209:etiology / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D002986:Clinical Trials as Topic; D006801:Humans; D009369:Neoplasms / Q000150:complications* / Q000503:physiopathology / Q000628:therapy; D011379:Prognosis; D015996:Survival Rate; D013997:Time Factors
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