title: Selectively functionalized cyclodextrins and their metal complexes.
abstract: Cyclodextrins (CDs) are cyclic oligomers of alpha-1,4-linked D-glucopyranose. Due to their unique structure, marked by a chiral and hydrophobic cavity, CDs have been extensively used as chiral selectors and drug delivery systems. The functionalization both improve the CD applications and widen their use in many other fields, such as molecular recognition and enzyme mimicking. Moreover, the functionalization highly increases the metal binding properties of the CDs. This critical review is a report of recent applications concerning the CD derivatives and their metal complexes. The metal ion assists the host-guest interaction often increasing the properties of CDs to act as chiral receptors. Furthermore, it can act as a catalytic center in the mimicking of metalloenzymes based on functionalized CDs (164 references).
authors.affiliation: Dipartimento di Scienze Chimiche, University of Catania, viale A. Doria 6, 95125, Catania, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Bellia
authors.forename: Diego
authors.initials: D
authors.lastname: La Mendola
authors.forename: Carlo
authors.initials: C
authors.lastname: Pedone
authors.forename: Enrico
authors.initials: E
authors.lastname: Rizzarelli
authors.forename: Michele
authors.initials: M
authors.lastname: Saviano
authors.forename: Graziella
authors.initials: G
authors.lastname: Vecchio
mesh_terms: D003505:Cyclodextrins / Q000737:chemistry / Q000378:metabolism / Q000502:physiology; D008670:Metals / Q000737:chemistry / Q000378:metabolism; D009930:Organic Chemicals / Q000737:chemistry / Q000378:metabolism
chemical_list: D003505:Cyclodextrins; D008670:Metals; D009930:Organic Chemicals