Coumarins from Angelica lucida L.--antibacterial activities.
The first phytochemical investigation of the fruits of Angelica lucida has led to the isolation and characterization of five known coumarins (imperatorin, isoimperatorin, heraclenol, oxypeucedanin hydrate and heraclenin). All isolated compounds were identified by means of spectral and literature data. The extracts and the isolated constituents from A. lucida have been also evaluated for their antimicrobial activity against six Gram positive and negative bacteria, two oral pathogens and three human pathogenic fungi, exhibiting an interesting antimicrobial profile.
Widelski
Jaroslaw
J
Department of Pharmacognosy with Medicinal Plant Laboratory, Skubiszewski Medicinal University of Lublin, 1 Chodzki str., 20-093, Poland.
Popova
Milena
M
Graikou
Konstantia
K
Glowniak
Kazimierz
K
Chinou
Ioanna
I
D029969:Angelica / Q000737:chemistry*; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D001578:Benzopyrans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D003374:Coumarins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D005638:Fruit / Q000737:chemistry; D005658:Fungi / Q000187:drug effects; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D011564:Furocoumarins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
D000890:Anti-Infective Agents; D001578:Benzopyrans; D003374:Coumarins; D005663:Furans; D011564:Furocoumarins; D010936:Plant Extracts; C055542:isoimperatorin; C087805:heraclenol; C047845:heraclenin; C031534:imperatorin; C031535:oxypeucadanin
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