title: Effect of selective vaccination on a decrease in the rate of hepatitis B virus-positive Japanese first-time blood donors.
abstract: The government of Japan started a selective vaccination programme to prevent mother-to-infant infection by hepatitis B virus (HBV) since January 1986. The effect of the programme on first-time blood donors has not been examined in detail. Data of first-time blood donors aged 16-25 years from 1996 to 2007 were extracted from the Japanese Red Cross (JRC) donors' database. Principal component analysis (PCA) was used to visualize the birth-year-dependent group of rate of HBV-positive donors. According to the birth of year, donors were divided into four groups by PCA. After the start of the programme, donors born in 1986-1989 comprised a single group. Before the start of the programme, three groups (1980, 1981-1984 and 1985) were identified. Although a significant time-dependent decrease in the rate of HBV-positive donors was observed before the start of the programme, a significant difference in the rate of HBV-positive donors was observed around the start of the programme by regression analysis for 16-19-year-old first-time blood donors. The selective vaccination programme has been effective to prevent the vertical transmission of HBV from the analysis of first-time blood donors. On the other hand, vaccination of blood donors should be considered to reduce the risk of post-transfusion HBV infection, because the horizontal transmission increases in HBV-positive blood donors.
authors.affiliation: Japanese Red Cross Saitama Blood Center, Hidaka-shi, Saitama-ken 350-1213, Japan. yoshikawa@saitama.bc.jrc.or.jp
authors.forename: A
authors.initials: A
authors.lastname: Yoshikawa
authors.forename: K
authors.initials: K
authors.lastname: Suzuki
authors.forename: A
authors.initials: A
authors.lastname: Abe
authors.forename: T
authors.initials: T
authors.lastname: Tanaka
authors.forename: K
authors.initials: K
authors.lastname: Yamaguchi
authors.forename: T
authors.initials: T
authors.lastname: Tanaka
authors.forename: Y
authors.initials: Y
authors.lastname: Ishikawa
authors.forename: K
authors.initials: K
authors.lastname: Minegishi
authors.forename: Y
authors.initials: Y
authors.lastname: Gotanda
authors.forename: H
authors.initials: H
authors.lastname: Yugi
authors.forename: S
authors.initials: S
authors.lastname: Uchida
authors.forename: M
authors.initials: M
authors.lastname: Satake
authors.forename: H
authors.initials: H
authors.lastname: Mizoguchi
authors.forename: K
authors.initials: K
authors.lastname: Tadokoro
mesh_terms: D000293:Adolescent; D000328:Adult; D001782:Blood Donors; D005260:Female; D006509:Hepatitis B / Q000517:prevention & control* / Q000635:transmission; D006515:Hepatitis B virus; D006801:Humans; D007564:Japan; D008297:Male; D012011:Red Cross; D012189:Retrospective Studies; D014611:Vaccination