title: Dramatic response of scarring scalp discoid lupus erythematosus (DLE) to intravenous methylprednisolone, oral corticosteroids, and hydroxychloroquine in a 5-year-old child.
abstract: Discoid lupus erythematosus (DLE) is rare in childhood. We report the case of a 5-year-old girl who presented with erythematous scaly plaques, with scarring alopecia, involving approximately 40% of her scalp. Histopathology confirmed the diagnosis of DLE. Treatment with intravenous methylprednisolone, hydroxychloroquine, oral prednisone, topical corticosteroids, and sunscreen lead to reversal of scarring alopecia and re-growth of hair.
authors.affiliation: Division of Rheumatology, Department of Pediatrics, University of Calgary, Calgary, Canada. Paivi.Miettunen@CalgaryHealthRegion.ca
authors.forename: Paivi M H
authors.initials: PM
authors.lastname: Miettunen
authors.forename: Andrea
authors.initials: A
authors.lastname: Bruecks
authors.forename: Todd
authors.initials: T
authors.lastname: Remington
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage*; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D002675:Child, Preschool; D002921:Cicatrix / Q000473:pathology; D004359:Drug Therapy, Combination; D004791:Enzyme Inhibitors; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage; D006197:Hair / Q000254:growth & development; D006801:Humans; D006886:Hydroxychloroquine / Q000008:administration & dosage*; D007223:Infant; D007262:Infusions, Intravenous; D008179:Lupus Erythematosus, Discoid / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D008775:Methylprednisolone / Q000008:administration & dosage*; D011241:Prednisone / Q000008:administration & dosage; D012536:Scalp Dermatoses / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000305:Adrenal Cortex Hormones; D000893:Anti-Inflammatory Agents; D004791:Enzyme Inhibitors; D005938:Glucocorticoids; D006886:Hydroxychloroquine; D011241:Prednisone; D008775:Methylprednisolone