Obesity and acute lung injury.
Acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS) are common indications for ICU admission and mechanical ventilation. ALI/ARDS also consumes significant health care resources and is a common cause of death in ICU patients. Obesity produces changes in respiratory system physiology that could affect outcomes for ALI/ARDS patients and their response to treatment. Additionally, the biochemical alterations seen in obese patients, such as increased inflammation and altered metabolism, could affect the risk of developing ALI/ARDS in patients with another risk factor (eg, sepsis). The few studies that have examined the influence of obesity on the outcomes from ALI/ARDS are inconclusive. Furthermore, observed results could be biased by disparities in provided care.
McCallister
Jennifer W
JW
Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Center for Critical Care, The Ohio State University Medical Center, Columbus, OH 43210, USA.
Adkins
Eric J
EJ
O'Brien
James M
JM
D055371:Acute Lung Injury / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D009102:Multiple Organ Failure / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D009765:Obesity / Q000150:complications* / Q000503:physiopathology* / Q000628:therapy; D012128:Respiratory Distress Syndrome / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D015656:Respiratory Mechanics / Q000502:physiology
Radiology. 2006 Aug;240(2):435-9
16801372
N Engl J Med. 2000 May 4;342(18):1301-8
10793162
Diabetes Care. 1998 Nov;21(11):1967-72
9802752
Int J Obes Relat Metab Disord. 2001 Aug;25(8):1246-52
11477511
AJR Am J Roentgenol. 2007 Feb;188(2):433-40
17242253
J Clin Endocrinol Metab. 1998 Jan;83(1):280-3
9435456
JAMA. 2000 Apr 19;283(15):1995-2002
10789668
N Engl J Med. 2001 Nov 8;345(19):1368-77
11794169
Crit Care Med. 2001 Dec;29(12):2325-31
11801836
Biochem Biophys Res Commun. 1999 Apr 2;257(1):79-83
10092513
Br J Anaesth. 1981 Aug;53(8):811-6
7272144
J Appl Physiol. 1960 May;15:377-82
14425845
Am J Respir Crit Care Med. 1997 Apr;155(4):1187-205
9105054
Curr Opin Crit Care. 2004 Dec;10(6):529-38
15616397
Obesity (Silver Spring). 2008 Jan;16(1):23-8
18223607
Anesth Analg. 1991 Dec;73(6):790-3
1835321
Clin Chest Med. 1982 Jan;3(1):35-56
7075161
Int J Obes. 1991 Apr;15(4):295-302
2071319
Cytokine Growth Factor Rev. 2003 Dec;14(6):523-35
14563354
J Clin Invest. 1967 Apr;46(4):475-81
6021200
Cell Mol Immunol. 2007 Feb;4(1):1-13
17349207
N Engl J Med. 2000 May 4;342(18):1334-49
10793167
J Clin Invest. 1958 Jul;37(7):1049-60
13563634
Semin Respir Crit Care Med. 2006 Aug;27(4):337-49
16909368
Chest. 1996 Dec;110(6):1425-9
8989055
Anesthesiology. 1999 Nov;91(5):1221-31
10551570
Anesthesiology. 2006 Jan;104(1):21-6
16394685
Chest. 2004 Feb;125(2):446-52
14769723
Br J Nutr. 1991 Mar;65(2):105-14
2043597
J Infect Dis. 1998 Sep;178(3):887-90
9728566
Women Health. 1993;20(2):45-57
8372479
Arch Intern Med. 2002 Jul 8;162(13):1477-81
12090884
Crit Care Med. 2000 Jul;28(7):2187-92
10921539
Nat Med. 2004 Jun;10(6):563-9
15170194
Am J Cardiol. 1997 Sep 15;80(6):736-40
9315579
Chest. 2007 Feb;131(2):342-8
17296631
Ann Intern Med. 2004 Mar 2;140(5):338-45
14996675
Crit Care Med. 2002 Jan;30(1):1-6
11902249
Anesthesiology. 1978 Apr;48(4):280-1
345874
Anesthesiology. 1984 Jul;61(1):27-35
6742481
Respir Med. 2001 Apr;95(4):281-6
11316110
Int J Biochem Cell Biol. 2006 Feb;38(2):267-78
16223598
J Clin Immunol. 1984 Nov;4(6):479-83
6511865
Crit Care Med. 2005 Jun;33(6):1191-8
15942330
Am J Respir Crit Care Med. 2004 Mar 1;169(5):557-61
14982823
Obes Surg. 2009 Jun;19(6):745-50
18629594
Anesthesiology. 1993 Apr;78(4):657-65
8466066
Am J Crit Care. 1994 Mar;3(2):102-6
8167771
Med Sci Monit. 2003 Feb;9(2):RA55-61
12601307
J Allergy Clin Immunol. 2005 May;115(5):911-9; quiz 920
15867843
Chest. 1993 May;103(5):1470-6
8486029
Int J Obes Relat Metab Disord. 1993 Dec;17(12):723-5
8118478
Anesth Analg. 2000 Dec;91(6):1520-5
11094011
Clin Chim Acta. 2005 Oct;360(1-2):9-26
15982646
Horm Metab Res. 1998 Dec;30(12):726-9
9930630
N Engl J Med. 2005 Oct 20;353(16):1685-93
16236739
Biochem Biophys Res Commun. 2004 Oct 15;323(2):630-5
15369797
Am J Respir Crit Care Med. 1994 Mar;149(3 Pt 1):818-24
7509706
N Engl J Med. 1962 Apr 26;266:861-3
13891266
Clin Chest Med. 2001 Dec;22(4):759-67
11787663
J Appl Physiol (1985). 1998 Oct;85(4):1236-43
9760311
Arterioscler Thromb Vasc Biol. 2003 Mar 1;23(3):434-9
12615693
Surgery. 1986 Jun;99(6):763-8
3715720
Respir Res. 2001;2(2):90-101
11686871
Chest. 2001 May;119(5):1401-8
11348945
Clin Pharmacokinet. 1996 Oct;31(4):275-92
8896944
Clin Pharmacokinet. 1993 Aug;25(2):103-14
8403734
Obes Surg. 2002 Apr;12(2):230-5
11975218
Chest. 2006 Nov;130(5):1579-95
17099041
Thorax. 1989 May;44(5):382-6
2503905
Eur J Surg. 1991 May;157(5):341-6
1678648
Crit Care Med. 2006 Mar;34(3):738-44
16521268
Chest. 1999 Jul;116(1 Suppl):18S-24S
10424566
Am J Cardiol. 1995 Dec 1;76(16):1194-7
7484912
Crit Care Med. 1996 Sep;24(9):1448-54
8797614
Am Rev Respir Dis. 1983 Sep;128(3):501-6
6614644
N Engl J Med. 2000 May 18;342(20):1471-7
10816184
Medicina (B Aires). 1991;51(6):524-8
7476105
Am Rev Respir Dis. 1960 Dec;82:787-91
13778537
Int J Obes. 1990 Feb;14(2):175-83
2111293
J Clin Invest. 2005 May;115(5):1111-9
15864338
J Infect Dis. 1999 Sep;180(3):908-11
10438392
Arch Surg. 2004 Sep;139(9):983-7
15381617
J Clin Anesth. 2005 Mar;17(2):134-45
15809132
Ann Surg. 1976 Jul;184(1):35-42
938116
Clin Endocrinol (Oxf). 2001 Feb;54(2):225-33
11207638
Obes Res. 1998 Sep;6 Suppl 2:51S-209S
9813653
Chest. 1996 Jan;109(1):144-51
8549177
J Trauma. 1991 Sep;31(9):1253-7
1920556
Obes Res. 1998 Nov;6(6):422-9
9845232
Lancet. 2008 Jan 12;371(9607):126-34
18191684
Clin Sci (Lond). 2008 Feb;114(4):275-88
18194136
Diabetes. 2008 Feb;57(2):378-86
18025413
Annu Rev Physiol. 2000;62:413-37
10845097
Am Rev Respir Dis. 1973 Oct;108(4):819-30
4741876
Anesth Analg. 1998 Sep;87(3):654-60
9728848
Am J Respir Crit Care Med. 2007 Mar 15;175(6):587-94
17185651
Chest. 2008 Jun;133(6 Suppl):381S-453S
18574271
Am J Med Sci. 1999 Nov;318(5):293-7
10555090
Chest. 2006 Sep;130(3):827-33
16963682
Am Rev Respir Dis. 1993 Nov;148(5):1169-73
8239149
Ann Intern Med. 1990 Jun 1;112(11):828-32
2378649
Lung. 2007 Dec;185(6):367-72
17909895
Arch Environ Health. 1972 Aug;25(2):146-50
5045066
Chest. 2008 Nov;134(5):974-980
18719063