title: Functional neuroimaging studies of aging and emotion: fronto-amygdalar differences during emotional perception and episodic memory.
abstract: Emotional processes are enhanced in aging, such that aging is characterized by superior emotional regulation. This article provides a brief review of the neural bases supporting this effect with a focus on functional neuroimaging studies of perception and episodic memory. The most consistent finding across these studies is that older adults show an alteration in the recruitment of the amygdala, but greater recruitment of the frontal cortex. These Fronto-amygdalar Age-related Differences in Emotion (FADE) may reflect emotional regulation strategies mediated by frontal brain regions that dampen emotion-related activations in the amygdala.
authors.affiliation: Center for Cognitive Neuroscience and Department of Psychology and Neuroscience, Duke University, Durham, NC 27708, USA. peggy.st.jacques@duke.edu
authors.forename: Peggy L
authors.initials: PL
authors.lastname: St Jacques
authors.forename: Brandy
authors.initials: B
authors.lastname: Bessette-Symons
authors.forename: Roberto
authors.initials: R
authors.lastname: Cabeza
mesh_terms: D000375:Aging / Q000502:physiology*; D000679:Amygdala / Q000502:physiology*; D001931:Brain Mapping; D003952:Diagnostic Imaging; D004644:Emotions / Q000502:physiology*; D005625:Frontal Lobe / Q000502:physiology*; D006801:Humans; D008568:Memory / Q000502:physiology*; D009434:Neural Pathways / Q000502:physiology; D010465:Perception / Q000502:physiology*
references.citation: J Neurosci. 2006 Jun 14;26(24):6422-30
references.pmid: 16775129
references.citation: J Neuropsychiatry Clin Neurosci. 1997 Summer;9(3):471-81
references.pmid: 9276848
references.citation: Nat Neurosci. 2007 Jun;10(6):787-91
references.pmid: 17468751
references.citation: Neurosci Biobehav Rev. 2006;30(6):730-48
references.pmid: 16919333
references.citation: Psychol Aging. 2008 Mar;23(1):209-15
references.pmid: 18361668
references.citation: Neuroimage. 2001 Jul;14(1 Pt 1):21-36
references.pmid: 11525331
references.citation: Ann N Y Acad Sci. 2008 Mar;1124:127-44
references.pmid: 18400928
references.citation: Annu Rev Neurosci. 2001;24:167-202
references.pmid: 11283309
references.citation: Neuroreport. 2008 Mar 5;19(4):447-52
references.pmid: 18287944
references.citation: Neuroimage. 2002 Jun;16(2):331-48
references.pmid: 12030820
references.citation: Cereb Cortex. 2008 May;18(5):1201-9
references.pmid: 17925295
references.citation: J Cogn Neurosci. 2006 Feb;18(2):227-41
references.pmid: 16494683
references.citation: Nat Rev Neurosci. 2006 Apr;7(4):268-77
references.pmid: 16552413
references.citation: Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):4259-64
references.pmid: 11259662
references.citation: Hum Brain Mapp. 2005 Aug;25(4):391-401
references.pmid: 15852381
references.citation: Trends Cogn Sci. 2005 May;9(5):242-9
references.pmid: 15866151
references.citation: Psychol Sci. 2004 Apr;15(4):259-63
references.pmid: 15043644
references.citation: Neurobiol Aging. 2006 Feb;27(2):361-74
references.pmid: 16399218
references.citation: Trends Cogn Sci. 2005 Oct;9(10):496-502
references.pmid: 16154382
references.citation: Neuroimage. 2008 Aug 15;42(2):956-68
references.pmid: 18586522
references.citation: Neuroimage. 2004 Sep;23(1):64-74
references.pmid: 15325353
references.citation: Neurosci Lett. 2005 Sep 30;386(2):99-104
references.pmid: 15993537
references.citation: J Neurosci. 2006 Apr 19;26(16):4415-25
references.pmid: 16624961
references.citation: Arch Neurol. 2001 Sep;58(9):1403-8
references.pmid: 11559311
references.citation: Biol Psychiatry. 2007 Dec 15;62(12):1388-95
references.pmid: 17336945
references.citation: Memory. 2007 Nov;15(8):822-37
references.pmid: 18033620
references.citation: Cogn Affect Behav Neurosci. 2008 Jun;8(2):153-64
references.pmid: 18589506
references.citation: Cereb Cortex. 2005 Nov;15(11):1676-89
references.pmid: 15703252
references.citation: Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):1942-7
references.pmid: 19171889
references.citation: J Comp Neurol. 1984 Dec 20;230(4):465-96
references.pmid: 6520247
references.citation: Trends Cogn Sci. 2007 May;11(5):219-27
references.pmid: 17382578
references.citation: J Cogn Neurosci. 2008 Jul;20(7):1161-73
references.pmid: 18284340
references.citation: Soc Neurosci. 2007;2(2):117-33
references.pmid: 18633811
references.citation: Neurobiol Aging. 2010 Feb;31(2):315-27
references.pmid: 18455837
references.citation: Trends Cogn Sci. 2004 Mar;8(3):102-7
references.pmid: 15301749
references.citation: Neurobiol Aging. 2003 Mar-Apr;24(2):285-95
references.pmid: 12498962
references.citation: Neuroimage. 1998 Apr;7(3):176-84
references.pmid: 9597659
references.citation: J Cogn Neurosci. 2009 Oct;21(10):1920-33
references.pmid: 18823239
references.citation: Nat Rev Neurosci. 2006 Jan;7(1):54-64
references.pmid: 16371950
references.citation: Hippocampus. 2002;12(3):352-62
references.pmid: 12099486
references.citation: Psychol Sci. 2009 Jan;20(1):74-84
references.pmid: 19152542
references.citation: Psychiatry Res. 2005 May 30;139(1):9-18
references.pmid: 15936178