title: Induction of autoimmunity by pristane and other naturally occurring hydrocarbons.
abstract: Tetramethylpentadecane (TMPD, or commonly known as pristane)-induced lupus is a murine model of systemic lupus erythematosus (SLE). Renal disease and autoantibody production strictly depend on signaling through the interferon (IFN)-I receptor. The major source of IFN-I is immature monocytes bearing high levels of the surface marker Ly6C. Interferon production is mediated exclusively by signaling through TLR7 and the adapter protein MyD88. It is likely that endogenous TLR7 ligands such as components of small nuclear ribonucleoprotein complexes are involved in triggering disease. Lupus autoantibodies are produced in ectopic lymphoid tissue developing in response to TMPD. This model is well suited for examining links between dysregulated IFN-I production and the pathogenesis of human SLE, which like TMPD-lupus, is associated with high levels of IFN-I.
authors.affiliation: Division of Rheumatology & Clinical Immunology, & Laboratory Medicine, University of Florida, PO Box 100221, Gainesville, FL 32610-0221, United States. whreeves@ufl.edu
authors.forename: Westley H
authors.initials: WH
authors.lastname: Reeves
authors.forename: Pui Y
authors.initials: PY
authors.lastname: Lee
authors.forename: Jason S
authors.initials: JS
authors.lastname: Weinstein
authors.forename: Minoru
authors.initials: M
authors.lastname: Satoh
authors.forename: Li
authors.initials: L
authors.lastname: Lu
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000276:immunology*; D004195:Disease Models, Animal; D006801:Humans; D007370:Interferon Type I / Q000276:immunology* / Q000378:metabolism; D008180:Lupus Erythematosus, Systemic / Q000139:chemically induced / Q000276:immunology*; D051379:Mice; D015398:Signal Transduction / Q000276:immunology; D013729:Terpenes / Q000276:immunology*; D055517:snRNP Core Proteins / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D007370:Interferon Type I; D013729:Terpenes; D055517:snRNP Core Proteins; C009042:pristane
references.citation: J Rheumatol. 1992 Sep;19(9):1342-7
references.pmid: 1432998
references.citation: J Immunol. 1996 Oct 1;157(7):3200-6
references.pmid: 8816434
references.citation: Blood. 2006 Apr 15;107(8):3229-34
references.pmid: 16368889
references.citation: J Immunol. 2008 Oct 1;181(7):4807-14
references.pmid: 18802084
references.citation: Food Addit Contam. 1997 Jan;14(1):83-8
references.pmid: 9059586
references.citation: J Immunol. 2008 Sep 1;181(5):3259-67
references.pmid: 18713997
references.citation: Am J Pathol. 2006 Apr;168(4):1227-40
references.pmid: 16565497
references.citation: J Exp Med. 1994 Dec 1;180(6):2341-6
references.pmid: 7964507
references.citation: Arthritis Rheum. 1989 Aug;32(8):1022-30
references.pmid: 2765002
references.citation: J Autoimmun. 2003 Aug;21(1):1-9
references.pmid: 12892730
references.citation: Carcinogenesis. 1992 Oct;13(10):1681-97
references.pmid: 1423827
references.citation: Toxicology. 2006 Feb 1;218(2-3):186-96
references.pmid: 16309812
references.citation: J Exp Med. 2005 Dec 5;202(11):1575-85
references.pmid: 16330816
references.citation: Kidney Int. 2001 Dec;60(6):2173-80
references.pmid: 11737591
references.citation: Nucleic Acids Res. 1985 Feb 25;13(4):1267-81
references.pmid: 2860635
references.citation: Hum Pathol. 1984 Aug;15(8):731-7
references.pmid: 6204920
references.citation: Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2610-5
references.pmid: 12604793
references.citation: J Clin Invest. 2005 Feb;115(2):407-17
references.pmid: 15668740
references.citation: Arthritis Rheum. 1998 Jul;41(7):1241-50
references.pmid: 9663482
references.citation: J Immunol. 2005 Dec 15;175(12):7867-79
references.pmid: 16339522
references.citation: Clin Immunol. 2005 Feb;114(2):110-8
references.pmid: 15639644
references.citation: J Exp Med. 2003 Mar 17;197(6):777-88
references.pmid: 12642605
references.citation: J Immunol. 2004 Apr 1;172(7):4418-24
references.pmid: 15034057
references.citation: J Exp Med. 1998 Sep 7;188(5):985-90
references.pmid: 9730900
references.citation: Toxicol Sci. 2004 Apr;78(2):222-8
references.pmid: 14718649
references.citation: Science. 2006 Jun 16;312(5780):1669-72
references.pmid: 16709748
references.citation: Immunol Rev. 2004 Dec;202:8-32
references.pmid: 15546383
references.citation: Clin Exp Immunol. 1999 Mar;115(3):547-53
references.pmid: 10193432
references.citation: Arthritis Rheum. 2007 Nov;56(11):3770-83
references.pmid: 17968932
references.citation: Genes Cells. 2001 Jul;6(7):631-40
references.pmid: 11473581
references.citation: Clin Exp Immunol. 2000 Aug;121(2):399-405
references.pmid: 10931159
references.citation: J Immunol. 2005 Mar 1;174(5):2499-506
references.pmid: 15728455
references.citation: Eur J Immunol. 2001 Sep;31(9):2726-32
references.pmid: 11536171
references.citation: Br J Rheumatol. 1997 Oct;36(10):1129
references.pmid: 9374935
references.citation: Immunology. 1974 Aug;27(2):311-30
references.pmid: 4214125
references.citation: Food Chem Toxicol. 2002 May;40(5):555-71
references.pmid: 11955662
references.citation: J Clin Invest. 2007 Jan;117(1):195-205
references.pmid: 17200719
references.citation: Immunity. 2006 Sep;25(3):383-92
references.pmid: 16979570
references.citation: Am J Clin Pathol. 1982 Jul;78(1):35-41
references.pmid: 7102605
references.citation: N Engl J Med. 1979 Jul 5;301(1):5-8
references.pmid: 449915
references.citation: Arthritis Res Ther. 2005;7(6):R1296-303
references.pmid: 16277683
references.citation: J Immunol. 1999 Dec 1;163(11):6306-13
references.pmid: 10570325
references.citation: J Lipid Res. 1968 May;9(3):350-2
references.pmid: 5646185
references.citation: Science. 2002 Sep 20;297(5589):2066-70
references.pmid: 12242446
references.citation: J Immunol. 2004 Apr 1;172(7):4410-7
references.pmid: 15034056
references.citation: J Exp Med. 1996 Apr 1;183(4):1461-72
references.pmid: 8666904
references.citation: J Exp Med. 2005 Oct 17;202(8):1131-9
references.pmid: 16230478
references.citation: Arthritis Rheum. 2000 Jul;43(7):1431-42
references.pmid: 10902743
references.citation: Arch Pathol Lab Med. 1985 Mar;109(3):283-6
references.pmid: 3838459
references.citation: J Clin Invest. 2008 Apr;118(4):1417-26
references.pmid: 18340381
references.citation: Genes Immun. 2007 Dec;8(8):653-62
references.pmid: 17882225
references.citation: J Immunol. 1981 Oct;127(4):1591-5
references.pmid: 7276572
references.citation: J Exp Med. 2008 Dec 22;205(13):2995-3006
references.pmid: 19047436
references.citation: Arch Intern Med. 1994 Mar 28;154(6):686-92
references.pmid: 8129503
references.citation: Nat Genet. 1998 Dec;20(4):401-4
references.pmid: 9843218
references.citation: Proc Natl Acad Sci U S A. 1995 Nov 21;92(24):10934-8
references.pmid: 7479913
references.citation: Eur J Immunol. 1995 Oct;25(10):2775-82
references.pmid: 7589071
references.citation: Am J Ind Med. 2003 May;43(5):539-42
references.pmid: 12704627
references.citation: J Am Soc Nephrol. 2007 Aug;18(8):2350-8
references.pmid: 17625118
references.citation: Clin Exp Immunol. 2005 Aug;141(2):230-7
references.pmid: 15996187
references.citation: Cancer Biochem Biophys. 1990 Apr;11(2):145-54
references.pmid: 2383857
references.citation: Nat Rev Immunol. 2008 Jan;8(1):22-33
references.pmid: 18097447
references.citation: Nature. 1969 Jun 7;222(5197):994-5
references.pmid: 5789334
references.citation: Nat Rev Immunol. 2006 Mar;6(3):205-17
references.pmid: 16498451
references.citation: Environ Health. 2007 Feb 22;6:8
references.pmid: 17316448
references.citation: Kidney Int. 2003 Sep;64(3):897-905
references.pmid: 12911539
references.citation: Immunity. 2003 Aug;19(2):225-34
references.pmid: 12932356
references.citation: Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):221-5
references.pmid: 8552609
references.citation: Arthritis Rheum. 2005 May;52(5):1491-503
references.pmid: 15880830
references.citation: Scand J Immunol. 1995 May;41(5):481-6
references.pmid: 7725067
references.citation: Hum Pathol. 1984 Aug;15(8):724-30
references.pmid: 6745914
references.citation: Clin Immunol. 2005 Dec;117(3):238-50
references.pmid: 16126005
references.citation: Clin Immunol. 2007 Jan;122(1):101-7
references.pmid: 17084107
references.citation: J Immunol. 2003 Sep 15;171(6):3296-302
references.pmid: 12960360
references.citation: J Clin Invest. 2004 Jun;113(12):1722-33
references.pmid: 15199407
references.citation: Ann Intern Med. 1991 Aug 1;115(3):178-83
references.pmid: 2058872
references.citation: Arthritis Rheum. 2008 Apr;58(4):1107-15
references.pmid: 18383384
references.citation: Food Addit Contam. 1994 Jan-Feb;11(1):79-89
references.pmid: 8181636
references.citation: J Clin Invest. 2007 Jan;117(1):185-94
references.pmid: 17200718
references.citation: Nature. 1962 Mar 17;193:1086-7
references.pmid: 14488296
references.citation: J Immunol. 2008 Apr 1;180(7):5101-8
references.pmid: 18354236
references.citation: Science. 1998 Feb 13;279(5353):1052-4
references.pmid: 9461440
references.citation: Arthritis Rheum. 2006 Sep;54(9):2951-62
references.pmid: 16947629
references.citation: Rheumatology (Oxford). 2007 Sep;46(9):1405-10
references.pmid: 17576695
references.citation: Arthritis Res Ther. 2006;8(4):R87
references.pmid: 16684366
references.citation: Nat Immunol. 2006 Feb;7(2):131-7
references.pmid: 16424890
references.citation: Curr Top Microbiol Immunol. 1985;122:221-33
references.pmid: 4042678
references.citation: EMBO J. 1990 Apr;9(4):1105-11
references.pmid: 2108862
references.citation: J Autoimmun. 1989 Aug;2(4):559-68
references.pmid: 2789658
references.citation: J Exp Med. 2003 Mar 17;197(6):711-23
references.pmid: 12642603
references.citation: J Immunol. 2009 Apr 1;182(7):4226-36
references.pmid: 19299721
references.citation: J Immunol. 2000 Jul 15;165(2):1036-43
references.pmid: 10878381