Hyperthermia exacerbates ischaemic brain injury.
Hyperthermia frequently occurs in stroke patients. Hyperthermia negatively correlates with clinical outcome and adversely effects treatment regiments otherwise successful under normothermic conditions. Preclinical studies also demonstrate that hyperthermia converts salvageable penumbra to ischaemic infarct. The present article reviews the knowledge accumulated from both clinical and preclinical studies about hyperthermia and ischaemic brain injury, examines current treatment strategies and discusses future research directions.
Wang
C X
CX
The Central Illinois Neuroscience Foundation, Bloomington, IL, USA. cwang@ilstu.edu
Stroink
A
A
Casto
J M
JM
Kattner
K
K
D001833:Body Temperature Regulation / Q000502:physiology; D001921:Brain / Q000473:pathology; D002545:Brain Ischemia / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D005334:Fever / Q000150:complications* / Q000378:metabolism; D006801:Humans; D007239:Infections / Q000150:complications; D018696:Neuroprotective Agents / Q000627:therapeutic use; D020521:Stroke / Q000209:etiology* / Q000473:pathology; D015912:Thrombolytic Therapy; D016896:Treatment Outcome
D018696:Neuroprotective Agents