Pulmonary epithelial lining fluid concentrations after use of systemic amphotericin B lipid formulations.
Amphotericin B (AMB) concentrations were determined in pulmonary epithelial lining fluid (ELF) of 44 critically ill patients, who were receiving treatment with liposomal AMB (LAMB) (n = 11), AMB colloidal dispersion (ABCD) (n = 28), or AMB lipid complex (ABLC) (n = 5). Mean AMB levels (+/- standard errors of the means) in ELF amounted to 1.60 +/- 0.58, 0.38 +/- 0.07, and 1.29 +/- 0.71 microg/ml in LAMB-, ABCD-, and ABLC-treated patients, respectively (differences are not significant).
Weiler
Stefan
S
Inflammation Research Laboratory, Department of Internal Medicine I, Innsbruck Medical University, Anichstrasse 35, A-6020 Innsbruck, Austria.
Falkensammer
Gerda
G
Hammerer-Lercher
Angelika
A
Anliker
Markus
M
Vogelsinger
Helene
H
Joannidis
Michael
M
Dunzendorfer
Stefan
S
Stein
Markus
M
Bellmann
Romuald
R
D000328:Adult; D000666:Amphotericin B / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000935:Antifungal Agents / Q000493:pharmacokinetics*; D004848:Epithelium / Q000378:metabolism; D005260:Female; D006801:Humans; D008168:Lung / Q000378:metabolism*; D008297:Male; D008875:Middle Aged
D000935:Antifungal Agents; C068538:liposomal amphotericin B; D000666:Amphotericin B
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