Acute neuroprotection to pilocarpine-induced seizures is not sustained after traumatic brain injury in the developing rat.
Following CNS injury there is a period of vulnerability when cells will not easily tolerate a secondary insult. However recent studies have shown that following traumatic brain injury (TBI), as well as hypoxic-ischemic injuries, the CNS may experience a period of protection termed "preconditioning." While there is literature characterizing the properties of vulnerability and preconditioning in the adult rodent, there is an absence of comparable literature in the developing rat. To determine if there is a window of vulnerability in the developing rat, post-natal day 19 animals were subjected to a severe lateral fluid percussion injury followed by pilocarpine (Pc)-induced status epilepticus at 1, 6 or 24 h post TBI. During the first 24 h after TBI, the dorsal hippocampus exhibited less status epilepticus-induced cell death than that normally seen following Pc administration alone. Instead of producing a state of hippocampal vulnerability to activation, TBI produced a state of neuroprotection. However, in a second group of animals evaluated 20 weeks post injury, double-injured animals were statistically indistinguishable in terms of seizure threshold, mossy fiber sprouting and cell survival when compared to those treated with Pc alone. TBI, therefore, produced a temporary state of neuroprotection from seizure-induced cell death in the developing rat; however, this ultimately conferred no long-term protection from altered hippocampal circuit rearrangements, enhanced excitability or later convulsive seizures.
Gurkoff
G G
GG
Department of Neurosurgery, David Geffen School of Medicine at University of California Los Angeles, 10833 Le Conte Avenue, 18-228 Semel Institute, Los Angeles, CA 90095-7039, USA.
Giza
C C
CC
Shin
D
D
Auvin
S
S
Sankar
R
R
Hovda
D A
DA
D000375:Aging; D000818:Animals; D001930:Brain Injuries / Q000473:pathology / Q000503:physiopathology*; D002452:Cell Count; D016923:Cell Death; D006624:Hippocampus / Q000254:growth & development* / Q000473:pathology / Q000503:physiopathology*; D007150:Immunohistochemistry; D008297:Male; D009474:Neurons / Q000473:pathology; D010862:Pilocarpine; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012640:Seizures / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology*; D013226:Status Epilepticus / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology*; D013997:Time Factors
D010862:Pilocarpine
Stroke. 2002 Dec;33(12):2738-43
12468763
J Basic Clin Physiol Pharmacol. 1996;7(1):23-43
8983334
Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2642-7
9482940
Behav Brain Res. 1983 Sep;9(3):315-35
6639740
Brain Res Bull. 1992 Sep-Oct;29(3-4):395-400
1327423
Neurosurgery. 2005 Feb;56(2):364-74; discussion 364-74
15670384
Neurology. 1978 May;28(5):488-94
306077
J Neurotrauma. 2000 Sep;17(9):739-49
11011814
Pediatr Res. 2006 Feb;59(2):237-43
16439585
Eur J Neurosci. 2006 Mar;23(5):1103-10
16553774
J Neurotrauma. 2003 May;20(5):409-20
12803974
Brain Res. 1986 Jul 30;379(1):104-11
3742206
J Neurotrauma. 1992 Mar;9 Suppl 1:S333-48
1588625
J Neurosurg. 1990 Dec;73(6):889-900
1977896
Exp Neurol. 1995 Dec;136(2):143-8
7498404
Brain Res. 1984 Oct 8;311(1):186-8
6488041
Brain Res. 2007 Dec 12;1184:270-6
18028886
J Comp Neurol. 1997 Oct 20;387(2):167-78
9336221
Epilepsy Res. 1997 Sep;28(2):129-36
9267777
J Neurotrauma. 2002 Apr;19(4):387-402
11990346
Brain Res. 1993 May 7;610(2):283-94
8319090
J Neurotrauma. 2005 Jul;22(7):763-71
16004579
J Neurotrauma. 2006 Jun;23(6):950-61
16774479
Behav Brain Res. 1995 Oct;70(2):125-31
8561903
J Neurotrauma. 2006 Jan;23(1):97-108
16430376
Exp Neurol. 1986 Mar;91(3):471-80
3948956
Ann Neurol. 2000 Oct;48(4):580-9
11026441
Behav Neurosci. 1989 Jun;103(3):574-84
2736072
Exp Neurol. 1988 Aug;101(2):267-75
3396644
Epilepsia. 2002;43 Suppl 5:47-53
12121295
J Cereb Blood Flow Metab. 1996 Mar;16(2):221-6
8594053
Crit Care Med. 2007 Dec;35(12):2830-6
18074483
J Cereb Blood Flow Metab. 1997 Feb;17(2):175-82
9040497
J Cereb Blood Flow Metab. 2003 Aug;23(8):900-10
12902834
Exp Brain Res. 1995;106(2):248-56
8566189
Epilepsia. 2003 Aug;44(8):1109-12
12887445
Brain Res Dev Brain Res. 1999 Dec 10;118(1-2):99-107
10611508
Science. 1983 Apr 15;220(4594):323-5
6301005
J Neurotrauma. 2002 May;19(5):573-85
12042093
J Neurochem. 1979 Aug;33(2):487-95
469539
APMIS. 1988 May;96(5):379-94
3288247
Brain Res. 1984 Apr 30;298(2):358-61
6722561
Neuroreport. 1998 Jun 22;9(9):2081-4
9674597
Brain Res. 1973 Dec 7;63:1-18
4587478
Brain Res. 1979 Mar 16;163(2):195-205
427544
Neurosurg Rev. 1989;12 Suppl 1:393-9
2812405
Brain. 1977 Jun;100(2):287-98
406963
J Neurosci. 1999 Sep 15;19(18):8152-62
10479715
Adv Tech Stand Neurosurg. 2005;30:3-49
16350451
Brain Res. 1997 May 16;757(1):119-32
9200506
Dev Neurosci. 2006;28(4-5):364-79
16943660
Exp Neurol. 1988 Dec;102(3):318-24
3197789
J Pharmacol Methods. 1985 Apr;13(2):135-46
3920448
Ann Neurol. 1982 May;11(5):491-8
7103425
Exp Eye Res. 2006 Nov;83(5):1128-34
16876158
J Neurochem. 1998 Sep;71(3):1215-20
9721747
J Neurosci Res. 2000 May 1;60(3):370-9
10797540
Brain Res. 1993 Jul 23;617(2):194-204
8402147
Neuroreport. 1999 Sep 29;10(14):2951-4
10549803
J Neurosurg. 1998 Dec;89(6):971-82
9833824
J Neurophysiol. 1947 Nov;10(6):409-14
20268874
J Neurotrauma. 1994 Dec;11(6):629-40
7723063
Intensive Care Med. 2008 Mar;34(3):551-60
17938889
Behav Neurosci. 1989 Aug;103(4):837-41
2765187
J Neurotrauma. 2000 Aug;17(8):649-65
10972242
Brain Res Brain Res Rev. 2000 Apr;32(1):269-76
10751677
Psychopharmacology (Berl). 1983;79(1):67-71
6403967
Brain Res. 1978 Jul 28;151(1):135-48
678999
J Neurosci. 1998 Oct 15;18(20):8382-93
9763481
J Head Trauma Rehabil. 2005 May-Jun;20(3):187-8
15908818
Brain Inj. 1987 Jul-Sep;1(1):27-32
3454667
Dev Med Child Neurol. 2000 Sep;42(9):591-4
11034451
Physiol Behav. 1988;44(1):27-37
2853377
Eur J Neurosci. 2002 Aug;16(3):501-13
12193194
Neurosci Lett. 1995 Feb 9;185(2):95-8
7746512
Electroencephalogr Clin Neurophysiol. 1972 Mar;32(3):281-94
4110397
Brain Res. 1992 Jun 26;583(1-2):120-6
1324090
Brain Res Bull. 1992 Nov;29(5):559-65
1330218
J Neurosci. 1998 Aug 1;18(15):5663-72
9671657
Neuroscience. 1987 Dec;23(3):953-68
3437996
Arch Neurol. 1973 Jan;28(1):10-7
4629379
Behav Brain Res. 2005 Feb 10;157(1):11-22
15617766
Epilepsy Res. 1994 Dec;19(3):191-204
7698095
J Neurotrauma. 2004 Jun;21(6):707-18
15253799
Brain Res. 1989 Jan 16;477(1-2):211-24
2702484
J Neurotrauma. 2003 Dec;20(12):1315-25
14748980
J Neurotrauma. 1994 Jun;11(3):275-87
7996582
J Neurotrauma. 1998 Oct;15(10):799-811
9814636
Acta Neuropathol. 1984;62(3):201-8
6695554
Pediatr Res. 2005 Feb;57(2):305-9
15611346
Brain Res Dev Brain Res. 1996 Sep 2;95(2):272-82
8874903
Brain Res. 1994 Jan 21;634(2):245-56
8131074
Brain Res. 2006 Mar 10;1077(1):24-36
16490184
Electroencephalogr Clin Neurophysiol. 1969 Jun;26(6):631
4181993
Epilepsia. 1999 May;40(5):584-9
10386527
Epilepsia. 2003 Apr;44(4):518-28
12681000
Brain Res. 1998 Nov 9;810(1-2):72-5
9813246
J Cereb Blood Flow Metab. 1992 Nov;12(6):996-1006
1356995
Dev Neurosci. 2001;23(3):219-23
11598324