title: The Arc of synaptic memory.
abstract: The immediate early gene Arc is emerging as a versatile, finely tuned system capable of coupling changes in neuronal activity patterns to synaptic plasticity, thereby optimizing information storage in the nervous system. Here, we attempt to overview the Arc system spanning from transcriptional regulation of the Arc gene, to dendritic transport, metabolism, and translation of Arc mRNA, to post-translational modification, localization, and degradation of Arc protein. Within this framework we discuss the function of Arc in regulation of actin cytoskeletal dynamics underlying consolidation of long-term potentiation (LTP) and regulation of AMPA-type glutamate receptor endocytosis underlying long-term depression (LTD) and homeostatic plasticity. Behaviorally, Arc has a key role in consolidation of explicit and implicit forms of memory, with recent work implicating Arc in adaptation to stress as well as maladaptive plasticity connected to drug addiction. Arc holds considerable promise as a "master regulator" of protein synthesis-dependent forms of synaptic plasticity, but the mechanisms that modulate and switch Arc function are only beginning to be elucidated.
authors.affiliation: Department of Biomedicine and Bergen Mental Health Research Center, University of Bergen, Jonas Lies vei 91, 5009, Bergen, Norway. clive.bramham@biomed.uib.no
authors.forename: Clive R
authors.initials: CR
authors.lastname: Bramham
authors.forename: Maria N
authors.initials: MN
authors.lastname: Alme
authors.forename: Margarethe
authors.initials: M
authors.lastname: Bittins
authors.forename: Sjoukje D
authors.initials: SD
authors.lastname: Kuipers
authors.forename: Rajeevkumar R
authors.initials: RR
authors.lastname: Nair
authors.forename: Balagopal
authors.initials: B
authors.lastname: Pai
authors.forename: Debabrata
authors.initials: D
authors.lastname: Panja
authors.forename: Manja
authors.initials: M
authors.lastname: Schubert
authors.forename: Jonathan
authors.initials: J
authors.lastname: Soule
authors.forename: Adrian
authors.initials: A
authors.lastname: Tiron
authors.forename: Karin
authors.initials: K
authors.lastname: Wibrand
mesh_terms: D000818:Animals; D003598:Cytoskeletal Proteins / Q000378:metabolism*; D006801:Humans; D008568:Memory / Q000502:physiology*; D008959:Models, Neurological; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009473:Neuronal Plasticity / Q000502:physiology; D009474:Neurons / Q000502:physiology; D013569:Synapses / Q000502:physiology*
chemical_list: D003598:Cytoskeletal Proteins; D009419:Nerve Tissue Proteins; C092069:activity regulated cytoskeletal-associated protein
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