The ubiquitin-proteasome system in cardiac proteinopathy: a quality control perspective.
Protein quality control (PQC) depends on elegant collaboration between molecular chaperones and targeted proteolysis in the cell. The latter is primarily carried out by the ubiquitin-proteasome system, but recent advances in this area of research suggest a supplementary role for the autophagy-lysosomal pathway in PQC-related proteolysis. The (patho)physiological significance of PQC in the heart is best illustrated in cardiac proteinopathy, which belongs to a family of cardiac diseases caused by expression of aggregation-prone proteins in cardiomyocytes. Cardiac proteasome functional insufficiency (PFI) is best studied in desmin-related cardiomyopathy, a bona fide cardiac proteinopathy. Emerging evidence suggests that many common forms of cardiomyopathy may belong to proteinopathy. This review focuses on examining current evidence, as it relates to the hypothesis that PFI impairs PQC in cardiomyocytes and contributes to the progression of cardiac proteinopathies to heart failure.
Su
Huabo
H
Division of Basic Biomedical Sciences, Sanford School of Medicine of the University of South Dakota, Lee Medical Building, 414 E Clark Street, Vermillion, SD 57069, USA.
Wang
Xuejun
X
D000818:Animals; D001343:Autophagy; D009202:Cardiomyopathies / Q000209:etiology*; D003893:Desmin / Q000502:physiology; D006333:Heart Failure / Q000209:etiology; D006801:Humans; D018832:Molecular Chaperones / Q000502:physiology; D032383:Myocytes, Cardiac / Q000378:metabolism; D046988:Proteasome Endopeptidase Complex / Q000502:physiology*; D061988:Proteasome Inhibitors; D011506:Proteins / Q000737:chemistry / Q000378:metabolism*; D025801:Ubiquitin / Q000378:metabolism*
D003893:Desmin; D018832:Molecular Chaperones; D061988:Proteasome Inhibitors; D011506:Proteins; D025801:Ubiquitin; D046988:Proteasome Endopeptidase Complex
Autophagy. 2009 Jul;5(5):732-3
19398892
J Biol Chem. 2005 Dec 2;280(48):40282-92
16192271
Circulation. 2006 Oct 24;114(17):1821-8
17043166
Trends Biochem Sci. 2008 Dec;33(12):592-600
18926707
Mech Ageing Dev. 2008 Sep;129(9):515-21
18533226
Genet Med. 2000 Jul-Aug;2(4):232-41
11252708
Nature. 2001 Dec 6;414(6864):652-6
11740563
Mol Cell Biol. 2000 Oct;20(19):7214-9
10982838
J Mol Cell Cardiol. 2008 Dec;45(6):821-31
18805423
Nature. 2007 Aug 9;448(7154):704-8
17687326
FASEB J. 2006 Feb;20(2):362-4
16371426
Cardiovasc Res. 2010 Jan 15;85(2):321-9
19578073
J Mol Cell Cardiol. 2006 Apr;40(4):451-4
16481005
Cardiovasc Pathol. 2009 Nov-Dec;18(6):332-45
19144543
Circ Res. 2007 Mar 30;100(6):914-22
17332429
Cell. 2008 Jan 11;132(1):27-42
18191218
FASEB J. 2005 Dec;19(14):2051-3
16188962
Am J Physiol Heart Circ Physiol. 2008 Oct;295(4):H1599-607
18708438
J Cell Biol. 2008 Jun 2;181(5):761-75
18519735
Circ Res. 2006 Dec 8;99(12):1315-28
17158347
Circulation. 2003 Feb 25;107(7):984-91
12600911
Cardiovasc Pathol. 2010 May-Jun;19(3):158-64
19375358
Cardiovasc Res. 2010 Jan 15;85(2):312-20
19744947
Trends Biochem Sci. 2004 Dec;29(12):637-40
15544949
Circ Res. 2006 Aug 18;99(4):362-71
16857966
Proc Natl Acad Sci U S A. 2004 Jul 6;101(27):10132-6
15220483
Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4377-82
17360532
Autophagy. 2009 Apr;5(3):428-9
19202352
FEBS Lett. 2007 Nov 27;581(28):5543-7
17991438
Circulation. 2008 Jun 17;117(24):3070-8
18541737
Leuk Lymphoma. 2006 Jan;47(1):171-3
16321846
Am J Physiol Heart Circ Physiol. 2005 Jun;288(6):H2836-42
15665051
Cardiovasc Res. 2008 Jul 1;79(1):89-96
18346979
Autophagy. 2008 Feb;4(2):141-50
17986870
J Mol Cell Cardiol. 2006 Oct;41(4):669-79
16928382
Biochim Biophys Acta. 2008 Dec;1786(2):153-77
18558098
Cell. 2008 Aug 22;134(4):668-78
18724939
Nature. 2007 Jun 14;447(7146):859-63
17568747
Nat Rev Mol Cell Biol. 2008 Sep;9(9):679-90
18698327
J Biol Chem. 2007 Jan 5;282(1):555-63
17092938
Cardiovasc Res. 2010 Jan 15;85(2):347-56
19578074
Trends Biochem Sci. 2003 Jan;28(1):26-31
12517449
Mol Cell Proteomics. 2009 Feb;8(2):302-15
18931337
Circ Res. 2008 Dec 5;103(12):1473-82
18974385
Nat Rev Mol Cell Biol. 2009 Feb;10(2):104-15
19165213
Circ Res. 2009 Jan 30;104(2):150-8
19179668
Nature. 2009 Jun 11;459(7248):861-5
19412159
J Card Fail. 2002 Dec;8(6 Suppl):S287-92
12555134
J Mol Biol. 2008 Dec 26;384(4):896-907
18929575
Nat Cell Biol. 2009 Jul;11(7):852-8
19543272
Mol Cell Biol. 2008 Jun;28(12):4018-25
18411298
Circulation. 2008 May 27;117(21):2743-51
18490523
J Mol Cell Cardiol. 2008 Jul;45(1):11-27
18495153
Science. 2001 May 25;292(5521):1552-5
11375494
Autophagy. 2009 Jan;5(1):120-1
19001866
Cancer Sci. 2009 Jan;100(1):24-8
19037995
EMBO J. 2009 Apr 8;28(7):889-901
19229298
Nature. 2008 Aug 28;454(7208):1088-95
18756251
Mol Cell Biol. 2008 Sep;28(17):5275-87
18573876
Nat Biotechnol. 2003 Aug;21(8):921-6
12872131
J Clin Invest. 2007 Jul;117(7):1782-93
17607355
Circ Res. 2001 Jul 6;89(1):84-91
11440982
Ann Neurol. 2005 Mar;57(3):457-61
15732117
Circ Res. 2005 Nov 11;97(10):1018-26
16210548
Trends Cell Biol. 2008 Jun;18(6):264-72
18495480
J Cell Mol Med. 2009 Feb;13(2):373-87
18793351
Am J Pathol. 2009 May;174(5):1705-14
19342365
Trends Cardiovasc Med. 2008 Apr;18(3):88-93
18436146
Cardiovasc Res. 2010 Jan 15;85(2):330-8
19617224
Biochem Biophys Res Commun. 2006 Apr 7;342(2):361-4
16483544
J Biol Chem. 2008 Jan 18;283(3):1437-1444
18006506
Cell Death Differ. 2009 Jan;16(1):31-8
19008922
Mol Cell Biol. 2002 Jan;22(2):626-34
11756557
Proteomics. 2003 Feb;3(2):208-16
12601813
Mol Cell. 2005 Feb 4;17(3):351-65
15694337
Cardiovasc Res. 2010 Jan 15;85(2):272-80
19617222
Cell. 2007 Aug 10;130(3):427-39
17693254
Nature. 2000 Apr 13;404(6779):770-4
10783891
Eur J Heart Fail. 2007 Aug;9(8):762-9
17481944
Cardiovasc Res. 2008 Feb 1;77(3):497-505
18006445
Anticancer Res. 2009 Mar;29(3):797-807
19414312
J Biol Chem. 2003 Jun 13;278(24):21517-25
12676932
Cell. 2009 Apr 3;137(1):133-45
19345192
Mol Cell Biol. 2008 Jun;28(11):3790-803
18285456
Autophagy. 2008 Feb;4(2):237-9
18094623
Science. 2001 Apr 20;292(5516):468-72
11292861
Genes Dev. 1999 Jul 15;13(14):1822-33
10421634
Cardiovasc Res. 2008 Aug 1;79(3):472-80
18375498
Science. 2007 Jan 12;315(5809):201-5
17218518
J Biol Chem. 2004 Sep 24;279(39):41095-103
15272002
J Clin Invest. 2007 Sep;117(9):2486-95
17786241
Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13592-7
16155124
J Mol Cell Cardiol. 2008 Mar;44(3):618-21
18308332
Am J Physiol Heart Circ Physiol. 2004 Sep;287(3):H1417-25
15105173
Biochem Biophys Res Commun. 2006 Feb 24;340(4):1125-33
16403436
Antioxid Redox Signal. 2005 May-Jun;7(5-6):538-46
15889999
Am J Physiol Heart Circ Physiol. 2008 Oct;295(4):H1385-93
18676687
Hypertension. 2008 Feb;51(2):302-8
18086945
Curr Biol. 2004 Sep 21;14(18):R754-6
15380085
Am J Physiol Heart Circ Physiol. 2008 Sep;295(3):H1206-H1215
18641278
J Neurosci. 2008 Aug 13;28(33):8189-98
18701681
Int J Hematol. 2008 Sep;88(2):219-222
18633693
Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9745-50
18621691
Cardiovasc Res. 2010 Jan 15;85(2):367-75
19564153
J Biol Chem. 2006 Oct 6;281(40):29776-87
16882669
Circ Res. 2003 Apr 18;92(7):715-24
12649263
Br J Haematol. 2007 Aug;138(3):396-7
17561972
FASEB J. 2008 Dec;22(12):4248-57
18728217
BMC Cancer. 2006 May 11;6:129
16689991
Cell Mol Life Sci. 2007 Oct;64(19-20):2525-41
17565442
Int J Biochem Cell Biol. 2009 Mar;41(3):615-24
18706515
Circulation. 2001 May 15;103(19):2402-7
11352891
Nat Cell Biol. 2005 Aug;7(8):742-9
16056265
Endocrinology. 2008 Nov;149(11):5384-90
18653708