Cerebellum development during childhood and adolescence: a longitudinal morphometric MRI study.
In addition to its well-established role in balance, coordination, and other motor skills, the cerebellum is increasingly recognized as a prominent contributor to a wide array of cognitive and emotional functions. Many of these capacities undergo dramatic changes during childhood and adolescence. However, accurate characterization of co-occurring anatomical changes has been hindered by lack of longitudinal data and methodologic challenges in quantifying subdivisions of the cerebellum. In this study we apply an innovative image analysis technique to quantify total cerebellar volume and 11 subdivisions (i.e. anterior, superior posterior, and inferior posterior lobes, corpus medullare, and three vermal regions) from anatomic brain MRI scans from 25 healthy females and 25 healthy males aged 5-24 years, each of whom was scanned at least three times at approximately 2-year intervals. Total cerebellum volume followed an inverted U shaped developmental trajectory peaking at age 11.8 years in females and 15.6 years in males. Cerebellar volume was 10% to 13% larger in males depending on the age of comparison and the sexual dimorphism remained significant after covarying for total brain volume. Subdivisions of the cerebellum had distinctive developmental trajectories with more phylogenetically recent regions maturing particularly late. The cerebellum's unique protracted developmental trajectories, sexual dimorphism, preferential vulnerability to environmental influences, and frequent implication in childhood onset disorders such as autism and ADHD make it a prime target for pediatric neuroimaging investigations.
Tiemeier
Henning
H
Child Psychiatry Branch, National Institute of Mental Health/NIH, Bethesda, MD 20892, USA. h.tiemeier@erasmusmc.nl
Lenroot
Rhoshel K
RK
Greenstein
Deanna K
DK
Tran
Lan
L
Pierson
Ronald
R
Giedd
Jay N
JN
D000293:Adolescent; D000328:Adult; D002525:Cerebellar Cortex / Q000033:anatomy & histology / Q000254:growth & development; D002531:Cerebellum / Q000033:anatomy & histology* / Q000254:growth & development*; D002648:Child; D015331:Cohort Studies; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D012044:Regression Analysis; D012727:Sex Characteristics; D055815:Young Adult
Comput Med Imaging Graph. 2002 Jul-Aug;26(4):251-64
12074920
Arch Neurol. 1998 Dec;55(12):1561-8
9865801
Biol Psychiatry. 2007 Jun 15;61(12):1361-9
16950217
Neuropsychopharmacology. 2004 Feb;29(2):373-84
14583743
J Neuropsychiatry Clin Neurosci. 2004 Summer;16(3):367-78
15377747
Proc Natl Acad Sci U S A. 2004 May 25;101(21):8174-9
15148381
Cortex. 2002 Sep;38(4):491-8
12465664
Neural Comput. 1999 Nov 15;11(8):2061-80
10578044
Nat Neurosci. 2003 Mar;6(3):309-15
12548289
Annu Rev Neurosci. 1997;20:61-90
9056708
AJNR Am J Neuroradiol. 2003 Apr;24(4):644-7
12695196
Neurosci Lett. 1999 Aug 6;270(3):149-52
10462116
Trends Neurosci. 1998 Sep;21(9):367-9
9735943
IEEE Trans Med Imaging. 2002 Oct;21(10):1280-91
12585710
J Hum Evol. 2003 Apr;44(4):401-29
12727461
IEEE Trans Med Imaging. 1998 Feb;17(1):87-97
9617910
Science. 1997 Oct 17;278(5337):412-9
9334292
Biol Psychiatry. 2005 Jun 1;57(11):1263-72
15949998
Child Dev. 2000 Jan-Feb;71(1):44-56
10836557
Neuroimage. 2002 Sep;17(1):61-76
12482068
Brain Res. 1979 Mar 16;163(2):195-205
427544
J Chem Neuroanat. 2003 Dec;26(4):243-52
14729127
J Neurosci. 2001 Jan 15;21(2):700-12
11160449
Neuroimage. 2007 Jul 15;36(4):1065-73
17513132
J Steroid Biochem Mol Biol. 2006 Dec;102(1-5):187-94
17113981
J Neurosci. 1993 Jul;13(7):2801-20
8331373
Neuroimage. 2009 May 15;46(1):39-46
19457380
Cereb Cortex. 1996 Sep-Oct;6(5):726-36
8921207
Cereb Cortex. 1996 Jul-Aug;6(4):551-60
8670681
Neuroimage. 1998 May;7(4 Pt 1):368-76
9626676
Brain Res. 2006 Apr 14;1083(1):39-49
16542644
Neuroimage. 2009 Jan 15;44(2):489-501
18835452
J Comput Assist Tomogr. 1994 Mar-Apr;18(2):192-205
8126267
Nat Rev Neurosci. 2006 Jul;7(7):511-22
16791141
Eur Psychiatry. 2008 Jun;23(4):289-99
17765485
Development. 1990 Jan;108(1):19-31
2351063
Eur J Neurosci. 1993 Sep 1;5(9):1145-55
8281319
Acta Neurobiol Exp (Wars). 1994;54(2):151-4
8053411
AJNR Am J Neuroradiol. 2001 Jun-Jul;22(6):1161-7
11415913
Neuroimage. 2005 May 1;25(4):1146-60
15850732
AJR Am J Roentgenol. 1994 Jan;162(1):123-30
8273650
Crit Rev Biomed Eng. 1994;22(5-6):401-65
8631195
Brain Res Dev Brain Res. 2003 Oct 10;145(1):117-39
14519499
J Neurocytol. 2002 Mar-Jun;31(3-5):373-85
12815254
Brain. 2000 May;123 ( Pt 5):1051-61
10775549
Cerebellum. 2006;5(2):77-88
16818382
Rev Neurol (Paris). 1990;146(10):564-9
2263818
Int Rev Neurobiol. 1997;41:61-82
9378611