title: Rhinovirus infections in children: a retrospective and prospective hospital-based study.
abstract: To analyze clinical characteristics and prevalence of rhinovirus infections in children in the hospital, we reviewed a retrospective dataset from a 20-year period, and conducted a short-term prospective study. Records of children and adolescents treated at our hospital during 1987-2006 with a documented rhinovirus infection were reviewed and compared with patients with other respiratory virus infections. Prospective study included all children >or=1 month of age admitted to pediatric infectious disease ward during an autumn period. Rhinoviruses were detected by reverse transcription-PCR and/or culture, and sequence analysis was used for virus typing. In the retrospective study, the median age of 580 children with rhinovirus infection was 1.9 years (interquartile range, 1.0-4.3 years), and 27% had an underlying medical condition. Eighty-four children (16% of in-patients) were treated at pediatric intensive care unit. Twenty-one children (4%) had a hospital-acquired rhinovirus infection. In the prospective study, rhinoviruses were detected in 28% of 163 hospital episodes. Acute wheezing illness was diagnosed in 61% of children with rhinovirus and in 31% of children with respiratory syncytial virus, enterovirus, or no study virus (P < 0.001). One-half of sequence-analyzed rhinovirus strains belonged to the newly identified C group. In conclusion, rhinovirus infections are a frequent cause of pediatric hospitalizations, and they are common also at the intensive care unit. Acute wheezing is the most frequent manifestation in hospital setting, but the range of clinical presentations is wide. Group C rhinoviruses may account for a large part of rhinovirus hospitalizations.
authors.affiliation: Department of Pediatrics, Turku University Hospital, Turku, Finland. ville.peltola@utu.fi
authors.forename: Ville
authors.initials: V
authors.lastname: Peltola
authors.forename: Tuomas
authors.initials: T
authors.lastname: Jartti
authors.forename: Anne
authors.initials: A
authors.lastname: Putto-Laurila
authors.forename: Jussi
authors.initials: J
authors.lastname: Mertsola
authors.forename: Raija
authors.initials: R
authors.lastname: Vainionpää
authors.forename: Matti
authors.initials: M
authors.lastname: Waris
authors.forename: Timo
authors.initials: T
authors.lastname: Hyypiä
authors.forename: Olli
authors.initials: O
authors.lastname: Ruuskanen
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003428:Cross Infection / Q000453:epidemiology / Q000473:pathology / Q000503:physiopathology; D005260:Female; D005838:Genotype; D006761:Hospitals; D006801:Humans; D007223:Infant; D008297:Male; D010850:Picornaviridae Infections / Q000453:epidemiology* / Q000473:pathology / Q000503:physiopathology; D015995:Prevalence; D011446:Prospective Studies; D012189:Retrospective Studies; D012229:Rhinovirus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*
references.citation: Thorax. 2009 Mar;64(3):252-7
references.pmid: 19052043
references.citation: Clin Infect Dis. 2003 Feb 1;36(3):299-305
references.pmid: 12539071
references.citation: Crit Care. 2006;10(5):R142
references.pmid: 17022805
references.citation: Pediatr Infect Dis J. 2008 Nov;27(11):974-80
references.pmid: 18833026
references.citation: Pediatrics. 1977 Sep;60(3):367-71
references.pmid: 197478
references.citation: J Allergy Clin Immunol. 2003 Jan;111(1):66-71
references.pmid: 12532098
references.citation: J Pediatr. 2006 Nov;149(5):721-4
references.pmid: 17095353
references.citation: J Infect Dis. 2008 Feb 1;197(3):382-9
references.pmid: 18248302
references.citation: Eur Respir J. 2008 Aug;32(2):314-20
references.pmid: 18448489
references.citation: Clin Infect Dis. 2006 Jul 15;43(2):266-8
references.pmid: 16779762
references.citation: Pediatr Infect Dis J. 2006 Aug;25(8):680-6
references.pmid: 16874165
references.citation: Pediatr Infect Dis J. 2007 Oct;26(10):904-8
references.pmid: 17901795
references.citation: J Allergy Clin Immunol. 2005 Sep;116(3):571-7
references.pmid: 16159626
references.citation: Pediatr Infect Dis J. 2008 Mar;27(3):213-7
references.pmid: 18277932
references.citation: Pediatr Infect Dis J. 2007 Dec;26(12):1133-6
references.pmid: 18043451
references.citation: J Infect Dis. 2003 Apr 15;187(8):1314-8
references.pmid: 12696012
references.citation: J Virol Methods. 1989 Jan;23(1):29-40
references.pmid: 2643611
references.citation: J Clin Microbiol. 1998 Jul;36(7):2081-3
references.pmid: 9650967
references.citation: PLoS One. 2007 Oct 03;2(10):e966
references.pmid: 17912345
references.citation: J Infect Dis. 2007 Dec 15;196(12):1754-60
references.pmid: 18190255
references.citation: Emerg Infect Dis. 2004 Jun;10(6):1095-101
references.pmid: 15207063
references.citation: J Clin Microbiol. 1987 Sep;25(9):1662-7
references.pmid: 2821062
references.citation: J Med Virol. 1999 Nov;59(3):378-84
references.pmid: 10502272
references.citation: J Infect Dis. 1987 Jul;156(1):43-9
references.pmid: 3036962
references.citation: Pediatr Infect Dis J. 2005 Oct;24(10):901-4
references.pmid: 16220089
references.citation: Pediatr Infect Dis J. 2001 Jun;20(6):574-81
references.pmid: 11419498
references.citation: J Clin Virol. 2006 Apr;35(4):463-6
references.pmid: 16406692
references.citation: Clin Infect Dis. 2004 Sep 1;39(5):681-6
references.pmid: 15356783
references.citation: J Infect Dis. 2007 Mar 15;195(6):773-81
references.pmid: 17299706
references.citation: J Clin Microbiol. 1995 Mar;33(3):648-53
references.pmid: 7751371
references.citation: Pediatr Infect Dis J. 2007 Nov;26(11):995-1000
references.pmid: 17984805
references.citation: J Med Virol. 2006 Sep;78(9):1232-40
references.pmid: 16847968
references.citation: J Allergy Clin Immunol. 2007 Mar;119(3):570-5
references.pmid: 17196244
references.citation: Am J Respir Crit Care Med. 2008 Oct 1;178(7):667-72
references.pmid: 18565953
references.citation: Am J Respir Crit Care Med. 2004 Jun 1;169(11):1187-90
references.pmid: 14754759
references.citation: J Pediatr. 1982 May;100(5):722-6
references.pmid: 6279812
references.citation: J Infect Dis. 2006 Nov 15;194(10):1398-402
references.pmid: 17054069
references.citation: Pediatr Infect Dis J. 2000 Apr;19(4):293-8
references.pmid: 10783017
references.citation: J Clin Microbiol. 1988 Dec;26(12):2581-5
references.pmid: 3068251
references.citation: Pediatr Infect Dis J. 2008 Dec;27(12):1103-7
references.pmid: 18978518