HPV as a model for the development of prophylactic and therapeutic cancer vaccines.
HPV has been linked to many human malignancies and, as such, represents a major public health crisis. The understanding of HPV biology, however, has helped tremendously in developing prophylactic vaccines, which should help in decreasing mortality due to HPV infections. Understanding HPV biology has allowed researchers to use the virus as a model for the development of not only prophylactic vaccines, but also therapeutic ones. The advantages of HPV as a model stem from the limited number of proteins encoded by the HPV genome that can be targeted by vaccines, and also from the restricted expression of certain viral proteins during different stages of infection. In this review, we discuss how HPV can be used as a model for the development of both prophylactic and therapeutic vaccines.
Samara
Raed N
RN
Cancer Vaccine Section, National Cancer Institute, NCI-NNMC, Bldg 10, Rm. 5101, Bethesda, MD 20889, USA.
Khleif
Samir N
SN
D019496:Cancer Vaccines / Q000627:therapeutic use*; D006801:Humans; D018448:Models, Immunological; D027383:Papillomaviridae / Q000276:immunology*; D030361:Papillomavirus Infections / Q000276:immunology / Q000517:prevention & control* / Q000628:therapy*; D053918:Papillomavirus Vaccines / Q000276:immunology / Q000627:therapeutic use; D014764:Viral Proteins / Q000276:immunology
D019496:Cancer Vaccines; D053918:Papillomavirus Vaccines; D014764:Viral Proteins
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