Human papillomavirus infection in Honduran women with normal cytology.
OBJECTIVE
This study was aimed at estimating type-specific HPV prevalence and its cofactors among Honduran women with normal cytology in order to provide valuable information to health policymakers about the epidemiology of this important sexually transmitted infection.


METHODS
A total of 591 women with normal cytology from Tegucigalpa, Honduras were interviewed and tested for HPV using the SPF10 LiPA25. A structured epidemiological questionnaire was administered to each woman.


RESULTS
The overall HPV prevalence was 51%. Twenty-three types of HPV were detected; HPV 16, 51, 31, 18, and 11 were the most common. The highest prevalence of cancer associated HPV types (15.0%) was found in the women less than 35 years. Besides the association with age, the main independent predictors of HPV infection were the lifetime number of sexual partners and having a low socioeconomic status and less than 5 previous Pap smears.


CONCLUSIONS
In the population studied, there was a broad diversity of HPV infections, with high-risk types being the most common types detected. The establishment of a well-characterized population with regard to the community prevalence of type-specific HPV infection will provide a valuable baseline for monitoring population effectiveness of an HPV vaccine.
Tábora
N
N
Department of Microbiology, Universidad Nacional Autónoma de Honduras (UNAH), Tegucigalpa, Honduras.
Bakkers
J M J E
JM
Quint
W G V
WG
Massuger
L F A G
LF
Matute
J A
JA
Melchers
W J G
WJ
Ferrera
A
A
D000328:Adult; D017677:Age Distribution; D000367:Age Factors; D005260:Female; D006721:Honduras / Q000453:epidemiology; D006801:Humans; D008875:Middle Aged; D027383:Papillomaviridae / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000821:virology*; D016133:Polymerase Chain Reaction; D011230:Precancerous Conditions / Q000453:epidemiology; D015995:Prevalence; D012307:Risk Factors; D012959:Socioeconomic Factors
Virus Res. 2007 May;125(2):176-82
17257705
Cancer Epidemiol Biomarkers Prev. 1999 Jul;8(7):615-20
10428199
J Natl Cancer Inst. 1998 Jan 7;90(1):43-9
9428782
Rev Inst Med Trop Sao Paulo. 2004 Jan-Feb;46(1):9-12
15057326
Cancer Epidemiol Biomarkers Prev. 2004 Dec;13(12):2271-6
15598792
J Clin Virol. 2000 Oct;19(1-2):1-5
11091143
Sex Transm Dis. 1996 Jul-Aug;23(4):333-41
8836027
J Clin Microbiol. 1990 Mar;28(3):495-503
1691208
Mutat Res. 1994 Mar 1;305(2):293-301
8121439
J Infect Dis. 2001 Jun 1;183(11):1554-64
11343204
Salud Publica Mex. 2003;45 Suppl 3:S306-14
14746023
Int J Cancer. 1998 Feb 9;75(4):546-54
9466654
Int J Cancer. 1993 Apr 1;53(6):919-23
8386137
Am J Trop Med Hyg. 1994 Feb;50(2):137-42
8116803
J Med Virol. 2004 Jun;73(2):262-8
15122802
Int J Cancer. 2000 Jul 15;87(2):221-7
10861478
CMAJ. 2001 Apr 3;164(7):1017-25
11314432
J Natl Cancer Inst. 1998 Jan 7;90(1):50-7
9428783
Int J Cancer. 2001 Feb 1;91(3):412-20
11169968
Infect Dis Obstet Gynecol. 2006;2006 Suppl:83084
16967913
N Engl J Med. 1989 Jun 1;320(22):1437-41
2541336
Int J Cancer. 2002 Nov 20;102(3):237-43
12397642
J Natl Cancer Inst. 1991 Jul 17;83(14):997-1003
1649312
Int J Cancer. 1999 Sep 9;82(6):799-803
10446444
CMAJ. 2000 Sep 5;163(5):503-8
11006760
Eur J Cancer. 2001 Jan;37(2):246-50
11166153
J Natl Cancer Inst. 2000 Mar 15;92(6):464-74
10716964
Int J Epidemiol. 2000 Oct;29(5):817-25
11034963
J Indian Med Assoc. 2000 Feb;98(2):49-52
11016150
Sex Transm Dis. 1993 Sep-Oct;20(5):274-8
8235925
J Clin Pathol. 2004 Jan;57(1):68-72
14693839
Br J Cancer. 2002 Jul 29;87(3):324-33
12177803
Int J Cancer. 2000 Feb 15;85(4):486-91
10699919
Cancer Epidemiol Biomarkers Prev. 1997 Oct;6(10):799-805
9332762
Clin Microbiol Rev. 2003 Jan;16(1):1-17
12525422
J Infect Dis. 1999 Nov;180(5):1415-23
10515798
J Natl Cancer Inst. 1995 Jun 7;87(11):796-802
7791229