Isocyanides and arylacetic acids: synthesis and reactivity of 3-aryl-2-acyloxyacrylamides, an example of serendipity-oriented synthesis.
Research progress is often promoted by unexpected results that open the way to new scenarios. In this communication, an unprecedented condensation of arylacetic acids and isocyanides and the unusual base-mediated rearrangement of the resulting products to give two novel classes of polysubstituted pyrrolones and pyrrolidinediones are reported.
Basso
Andrea
A
Dipartimento di Chimica e Chimica Industriale, Università degli Studi di Genova, Genova, Italy. andreab@chimica.unige.it
Banfi
Luca
L
Galatini
Andrea
A
Guanti
Giuseppe
G
Rastrelli
Federico
F
Riva
Renata
R