title: [Long-term treatment with oral ketamine. Case report of a female patient with therapy-resistant post-herpetic neuralgia].
abstract: Postherpetic neuralgia can lead to therapy-resistant neuropathic pain. We report the case of a 74-year-old woman with postherpetic perineal neuralgia resistant to opioids and antiepileptic drugs who has been successfully treated with oral ketamine for 28 months. Pain scores were reduced by more than 50%, despite dose reduction of other analgetic drugs. Significant side effects have not yet been reported. Despite "off-label" use, ketamine is an important third line option in cases of therapy-resistant neuropathic pain.
authors.affiliation: Klinik für Anästhesiologie, Intensivmedizin und Schmerztherapie, Marienhospital Bottrop gGmbH, Josef-Albers-Str. 70, 46236 Bottrop. christian.zimmer@mhb-bottrop.de
authors.forename: C
authors.initials: C
authors.lastname: Zimmer
authors.forename: T A
authors.initials: TA
authors.lastname: Treschan
authors.forename: S
authors.initials: S
authors.lastname: Meier
authors.forename: M
authors.initials: M
authors.lastname: Nosch
mesh_terms: D000284:Administration, Oral; D000368:Aged; D000700:Analgesics / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007649:Ketamine / Q000008:administration & dosage*; D008134:Long-Term Care; D051474:Neuralgia, Postherpetic / Q000188:drug therapy*; D010147:Pain Measurement; D010148:Intractable Pain / Q000188:drug therapy
chemical_list: D000700:Analgesics; D007649:Ketamine
references.citation: Br J Anaesth. 1981 Aug;53(8):805-10
references.pmid: 7272143
references.citation: Pain. 1999 Nov;83(2):283-7
references.pmid: 10534600
references.citation: Pain. 1995 May;61(2):221-228
references.pmid: 7659432
references.citation: Pain Med. 2008 Mar;9(2):253-7
references.pmid: 18298710
references.citation: Anesth Analg. 2003 Dec;97(6):1730-1739
references.pmid: 14633551
references.citation: Neurobiol Dis. 1998 Oct;5(4):209-27
references.pmid: 9848092
references.citation: J Pain Symptom Manage. 1999 Jul;18(1):61-6
references.pmid: 10439575
references.citation: PLoS Med. 2005 Jul;2(7):e164
references.pmid: 16013891
references.citation: Pain. 1991 Mar;44(3):293-299
references.pmid: 1828878
references.citation: Clin J Pain. 1994 Sep;10(3):240-2
references.pmid: 7833583