The mechanisms of vision loss associated with a cotton wool spot.
We characterized the perceptual, functional, and structural abnormalities associated with retinal ischemia during a cotton wool spot episode and its sequelae. The border of the visually salient field anomaly mirrored the quantitatively measured relative scotoma. Results of resolution perimetry and high resolution imaging indicated that there was a substantial loss of retinal ganglion cells within the affected region. A disruption in retinal nerve fiber arrangement was found at the cotton wool spot and within the arcuate relative scotoma. The presence of the arcuate relative scotoma is consistent with the hypothesis of failed signal transmission along the axons that pass through the cotton wool spot. The different levels of loss associated with the arcuate and focal scotomas indicate different underlying pathologies.
Chui
Toco Y P
TY
School of Optometry, Indiana University, 800 E. Atwater Ave., Bloomington, IN 47405, USA. ypchui@indiana.edu
Thibos
Larry N
LN
Bradley
Arthur
A
Burns
Stephen A
SA
D016923:Cell Death; D015350:Contrast Sensitivity / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009887:Ophthalmoscopy; D011601:Psychophysics; D012165:Retinal Ganglion Cells / Q000473:pathology; D012607:Scotoma / Q000150:complications* / Q000473:pathology / Q000523:psychology; D041623:Tomography, Optical Coherence; D014786:Vision Disorders / Q000209:etiology* / Q000473:pathology; D014792:Visual Acuity / Q000502:physiology; D058609:Visual Field Tests; D014794:Visual Fields / Q000502:physiology
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