[Does acidosis in brain play a role in Alzheimer's disease?].
Alzheimer's disease is characterized by beta-amyloid plaques, tau pathology, cell death of cholinergic neurons, inflammatory processes and cerebrovascular damage. The reasons for the development of this chronic disease are not known yet. We hypothesize that chronic long lasting mild damage of the cerebrovascular brain capillaries cause hypoperfusion, acidosis and neurodegeneration, and induces a cell death cascade with beta-amyloid dysfunction and tau-pathology and inflammation. Vascular risk factors, such as hyperhomocysteinemia or hypercholesterolemia, may play a role in this process. The accumulation of chronic silent strokes may cause cognitive defects as seen in vascular dementia and Alzheimer's disease. This summary tries to link the different events, which occur in Alzheimer's disease, focusing on the cerebrovascular hypothesis.
Pirchl
Michael
M
Psychiatrisches Labor für Experimentelle Alzheimerforschung, Univ. Klinik für Allgemeine Psychiatrie und Sozialpsychiatrie, Medizinische Universität Innsbruck.
Humpel
Christian
C
D000138:Acidosis / Q000503:physiopathology*; D000544:Alzheimer Disease / Q000503:physiopathology*; D016229:Amyloid beta-Peptides / Q000378:metabolism; D001812:Blood-Brain Barrier / Q000502:physiology; D001921:Brain / Q000503:physiopathology*; D002545:Brain Ischemia / Q000503:physiopathology; D016923:Cell Death / Q000502:physiology; D002536:Cerebral Arteries / Q000503:physiopathology; D002784:Cholesterol / Q000378:metabolism; D006710:Homocysteine / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D019344:Lactic Acid / Q000378:metabolism; D009474:Neurons / Q000502:physiology; D012307:Risk Factors; D016875:tau Proteins / Q000378:metabolism
D016229:Amyloid beta-Peptides; D016875:tau Proteins; D006710:Homocysteine; D019344:Lactic Acid; D002784:Cholesterol