A case report supporting the concept that some women have a predisposition for maternal meiosis errors resulting in digyny.
OBJECTIVE
To determine if a primary aborter with recurrent miscarriage times three with her only two fetal products that were evaluated with chromosome analysis demonstrating triploidy in both fetuses could have a predisposition for maternal meiosis errors.


METHODS
In vitro fertilization with intracytoplasmic sperm injection was performed. Embryo biopsy was performed on 3-day old embryos and a single blastomere was evaluated by fluorescent in situ hybridization (FISH). Embryo transfer would be performed on day 5 at the blastocyst stage.


RESULTS
There were six normal and seven abnormal embryos. One of the seven was a tetraploid embryo (92XXXX).


CONCLUSIONS
The majority of triploidies are related to polyspermy but this factor was excluded by performing ICSI. Thus this woman showed a marked predisposition to digyny. Though the tetraploidy could be explained by fertilization of a digynic egg by a diploid sperm the probability was that in this instance the meiosis error extended back to failure to extrude the first polar body.
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J H
JH
The University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden, Cooper Hospital/University Medical Center, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology & Infertility, Camden, NJ, USA. laurie@ccivf.com
Katsoff
B
B
Summers-Chase
D
D
Breitbart
J
J
D000026:Abortion, Habitual / Q000235:genetics*; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D008540:Meiosis / Q000235:genetics*; D010063:Ovum; D011123:Polyploidy; D011247:Pregnancy; D019836:Preimplantation Diagnosis; D055815:Young Adult