Antitumoractive endoperoxides from triterpenes.
A series of triterpene endoperoxides was synthesized and screened for antitumor activity in a panel of 15 human cancer cell lines by a sulforhodamine-B (SRB) assay. The compounds induce apoptosis and show excellent antitumor activity.
Niesen
Anja
A
Martin-Luther-Universität Halle-Wittenberg, Organische Chemie, Halle (Saale), Germany.
Barthel
Alexander
A
Kluge
Ralph
R
Köwitzsch
Alexander
A
Ströhl
Dieter
D
Schwarz
Stefan
S
Csuk
René
R
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D010545:Peroxides / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014315:Triterpenes / Q000138:chemical synthesis / Q000494:pharmacology*
D000970:Antineoplastic Agents; D010545:Peroxides; D014315:Triterpenes