title: Serum proteins and fractions, HDL-cholesterol and total IgG and IgE levels in cases of acute and chronic paracoccidioidomycosis.
abstract: This study evaluated serum protein fractions, HDL-cholesterol, total immunoglobulin G and total immunoglobulin E levels in patients with acute and chronic paracoccidioidomycosis, by means of electrophoresis, enzymatic reaction and immunoenzymatic assay. The results demonstrated elevated levels of total immunoglobulin G, total immunoglobulin E, alpha-2 and gamma-globulins, which were more evident in acute than in chronic PCM, but no increase in HDL-cholesterol levels. There was a correlation between the levels of total immunoglobulin E and gamma-globulins and the alpha-2 and beta-globulin fractions in the acute form and between beta and gamma-globulins in both the acute and the chronic form. In conclusion, changes in total immunoglobulin G and immunoglobulin E levels and in the electrophoretic profile may be important markers for the prognosis and therapeutic follow-up of PCM cases, especially because protein electrophoresis is a simple laboratory test that can be applied when specific PCM serological tests are not available. In addition, levels of the gamma-globulin fraction greater than 2.0 g/dl may suggest that the patient is developing a more severe form of PCM.
authors.affiliation: Microbiology Post-Graduation Program, Department of Microbiology, State University of Londrina, Londrina, PR, Brazil.
authors.forename: Audrey de Souza
authors.initials: Ade S
authors.lastname: Marquez
authors.forename: Adriana Pardini Vicentini
authors.initials: AP
authors.lastname: Moreira
authors.forename: Paula Cesar
authors.initials: PC
authors.lastname: Leonello
authors.forename: Fernanda Akemi
authors.initials: FA
authors.lastname: Nakanishi
authors.forename: Eiko Nakagawa
authors.initials: EN
authors.lastname: Itano
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D001798:Blood Proteins / Q000032:analysis*; D002648:Child; D008076:Cholesterol, HDL / Q000097:blood*; D002908:Chronic Disease; D004588:Electrophoresis, Cellulose Acetate; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D005779:Immunodiffusion; D007073:Immunoglobulin E / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010229:Paracoccidioidomycosis / Q000097:blood* / Q000276:immunology; D012016:Reference Values; D055815:Young Adult
chemical_list: D015415:Biomarkers; D001798:Blood Proteins; D008076:Cholesterol, HDL; D007074:Immunoglobulin G; D007073:Immunoglobulin E