title: IGF-1: elixir for motor neuron diseases.
abstract: Modulation of testosterone levels is a therapeutic approach for spinal and bulbar muscular atrophy (SBMA), a polyglutamine disorder that affects the motor neurons. The article by Palazzolo et al. in this issue of Neuron provides compelling evidence that the expression of insulin growth hormone is a potential therapeutic for SBMA.
authors.affiliation: The Buck Institute for Age Research, Novato, CA 94945, USA.
authors.forename: Theodora
authors.initials: T
authors.lastname: Papanikolaou
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Ellerby
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000235:genetics / Q000378:metabolism*; D016472:Motor Neuron Disease / Q000235:genetics / Q000378:metabolism* / Q000473:pathology / Q000628:therapy*; D018482:Muscle, Skeletal / Q000378:metabolism
chemical_list: D007334:Insulin-Like Growth Factor I