title: Critical role of external axial ligands in chirality amplification of trans-cyclohexane-1,2-diamine in salen complexes.
abstract: A series of Mn(IV)(salen)(L)(2) complexes bearing different external axial ligands (L = Cl, NO(3), N(3), and OCH(2)CF(3)) from chiral salen ligands with trans-cyclohexane-1,2-diamine as a chiral scaffold are synthesized, to gain insight into conformational properties of metal salen complexes. X-ray crystal structures show that Mn(IV)(salen)(OCH(2)CF(3))(2) and Mn(IV)(salen)(N(3))(2) adopt a stepped conformation with one of two salicylidene rings pointing upward and the other pointing downward due to the bias from the trans-cyclohexane-1,2-diamine moiety, which is in clear contrast to a relatively planar solid-state conformation for Mn(IV)(salen)(Cl)(2). The CH(2)Cl(2) solution of Mn(IV)(salen)(L)(2) shows circular dichroism of increasing intensity in the order L = Cl < NO(3) << N(3) < OCH(2)CF(3), which indicates Mn(IV)(salen)(L)(2) adopts a solution conformation of an increasing chiral distortion in this order. Quantum-chemical calculations with a symmetry adapted cluster-configuration interaction method indicate that a stepped conformation exhibits more intense circular dichroism than a planar conformation. The present study clarifies an unexpected new finding that the external axial ligands (L) play a critical role in amplifying the chirality in trans-cyclohexane-1,2-diamine in Mn(IV)(salen)(L)(2) to facilitate the formation of a chirally distorted conformation, possibly a stepped conformation.
authors.affiliation: Institute for Molecular Science, National Institutes of Natural Sciences, Myodaiji, Okazaki, Aichi 444-8787, Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Kurahashi
authors.forename: Masahiko
authors.initials: M
authors.lastname: Hada
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Fujii
mesh_terms: D002942:Circular Dichroism; D018360:Crystallography, X-Ray; D003514:Cyclohexylamines / Q000737:chemistry*; D008024:Ligands; D008958:Models, Molecular; D008968:Molecular Conformation; D009942:Organometallic Compounds / Q000737:chemistry*; D012996:Solutions; D013237:Stereoisomerism
chemical_list: D003514:Cyclohexylamines; D008024:Ligands; C542902:Mn-salen; D009942:Organometallic Compounds; D012996:Solutions; C030435:1,2-cyclohexanediamine