title: Antimalarial activity of the novel quinoline/6-thiopurine conjugate in Gallus gallus Linnaeus, infected experimentally by Plasmodium (Novyella) juxtanucleare.
abstract: This study aimed to evaluate the 4-(6'-thiopurine)-7-chloroquinoline, a novel quinoline/6-thiopurine conjugate, for the treatment of Gallus gallus experimentally infected with Plasmodium juxtanucleare, an avian malaria agent. The avian group treated with 4-(6'-thiopurine)-7-chloroquinoline showed a significative parasite clearance and maintained a low level of parasitaemia, when compared with the untreated control group and to the chloroquine treated avian group.
authors.affiliation: Departamento de Biologia, Instituto de Ciências Biológicas, Universidade Federal de Juiz de Fora, Juiz de Fora, M.G. 36036-900, Brazil.
authors.forename: Usha
authors.initials: U
authors.lastname: Vashist
authors.forename: Rafael
authors.initials: R
authors.lastname: Carvalhaes
authors.forename: Marta
authors.initials: M
authors.lastname: D'agosto
authors.forename: Adilson David
authors.initials: AD
authors.lastname: da Silva
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002645:Chickens; D002738:Chloroquine / Q000737:chemistry / Q000494:pharmacology; D004195:Disease Models, Animal; D008289:Malaria, Avian / Q000188:drug therapy; D018512:Parasitemia / Q000188:drug therapy; D010961:Plasmodium / Q000187:drug effects*; D011687:Purines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D011804:Quinolines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: C545295:4-(6'-thiopurine)-7-chloroquinoline; D000962:Antimalarials; D011687:Purines; D011804:Quinolines; D002738:Chloroquine