title: Antibody responses in oral fluid after administration of prophylactic human papillomavirus vaccines.
abstract: We sought to determine whether oral fluid can be used to assess serum human papillomavirus (HPV) antibody status by enrolling women who had received a prophylactic HPV-16 vaccine in a new follow-up study. After the prophylactic HPV-6/11/16/18 vaccine was licensed in the United States, we administered it to consenting participants. With serologic findings used as the reference standard, The sensitivity of oral fluid was 49.6% (95% confidence interval [CI], 42.0%-57.3%) before and 100% (95% CI, 92.0%-100%) after administration of the quadrivalent vaccine. Oral fluid may have the potential to be used for monitoring of prophylactic HPV vaccines in the future.
authors.affiliation: Department of Epidemiology, University of Washington, Seattle, WA 98125, USA. rowhani@u.washington.edu
authors.forename: Ali
authors.initials: A
authors.lastname: Rowhani-Rahbar
authors.forename: Joseph J
authors.initials: JJ
authors.lastname: Carter
authors.forename: Stephen E
authors.initials: SE
authors.lastname: Hawes
authors.forename: James P
authors.initials: JP
authors.lastname: Hughes
authors.forename: Noel S
authors.initials: NS
authors.lastname: Weiss
authors.forename: Denise A
authors.initials: DA
authors.lastname: Galloway
authors.forename: Laura A
authors.initials: LA
authors.lastname: Koutsky
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis / Q000276:immunology*; D005122:Exudates and Transudates / Q000276:immunology*; D005260:Female; D000068857:Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18; D052162:Human papillomavirus 16 / Q000276:immunology*; D006801:Humans; D007117:Immunization, Secondary; D007074:Immunoglobulin G / Q000032:analysis / Q000276:immunology*; D009061:Mouth Mucosa / Q000276:immunology; D053918:Papillomavirus Vaccines / Q000276:immunology*; D012372:ROC Curve; D016032:Randomized Controlled Trials as Topic
chemical_list: D000914:Antibodies, Viral; D000068857:Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18; D007074:Immunoglobulin G; D053918:Papillomavirus Vaccines
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