title: Analysis of the relative deformation of lung lobes before and after surgery in patients with NSCLC.
abstract: An accurate assessment of the extent of the tumor is critical for successful local treatment of lung cancer by surgery and/or radiotherapy. Guidelines to establish the extent of treatment margins may be derived from correlation studies between pre-treatment imaging and histopathology. Deformations occur, however, between in-vivo CT imaging and ex-vivo pathology due to the softness of lung tissue and pathology processing. The first aim of this study was to quantify these deformations in tissue around non-small cell lung cancer. The second aim was to explore factors associated with the magnitude of the deformations. The study was performed in 25 patients who underwent lobectomy after preoperative CT. Non-rigid registration was employed to evaluate tissue deformations around the gross tumor volume (GTV), taking into account potential differences in elasticity between tumor and healthy lung tissue. Tissue was found to be compacted by approximately 60% depending on circularity of the tumor and orientation of the specimen on the pathology table during processing. The deformations give rise to potential underestimation of the treatment margins in pathology studies that do not take this aspect into account.
authors.affiliation: The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Radiotherapy Department, Amsterdam, The Netherlands.
authors.forename: Ch
authors.initials: Ch
authors.lastname: Siedschlag
authors.forename: J
authors.initials: J
authors.lastname: van Loon
authors.forename: A
authors.initials: A
authors.lastname: van Baardwijk
authors.forename: M M G
authors.initials: MM
authors.lastname: Rossi
authors.forename: R
authors.initials: R
authors.lastname: van Pel
authors.forename: J L G
authors.initials: JL
authors.lastname: Blaauwgeers
authors.forename: R J
authors.initials: RJ
authors.lastname: van Suylen
authors.forename: L
authors.initials: L
authors.lastname: Boersma
authors.forename: J
authors.initials: J
authors.lastname: Stroom
authors.forename: K G A
authors.initials: KG
authors.lastname: Gilhuijs
mesh_terms: D000328:Adult; D000368:Aged; D000465:Algorithms; D002289:Carcinoma, Non-Small-Cell Lung / Q000000981:diagnostic imaging* / Q000601:surgery*; D005260:Female; D006801:Humans; D008168:Lung; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D011856:Radiographic Image Enhancement / Q000379:methods; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods*