title: Association and impact of XPG Asp 1104 His gene polymorphism in HIV 1 disease progression to AIDS among north Indian HIV seropositive individuals.
abstract: Various efforts made to stop the deadly epidemic of HIV since its discovery in 1983 remain unsuccessful and this virus still continues to claim the lives of millions of individuals every year. The viral effect in the cell is complicated and the overall disease outcome is the result of interaction between a few viral proteins and complex host immune response. Because it has been reported that XPG (Xeroderma pigementesum group G) gene does play a role in reducing UV induced apoptosis and participate in Nucleotide Excision Repair (NER) process of DNA damage, it was hypothesized that polymorphism in this gene may have a role in HIV 1 disease progression to AIDS. The aim of the present study, therefore, was to find out the association between XPG gene polymorphism and its effect on the rate of HIV 1 disease progression to AIDS. 300 HIV seropositive cases and an equal number of age and sex matched controls were recruited for the study from north Indian population. The PCR-RFLP method was utilized to genotype 600 study subject for the XPG Asp (1104) His gene polymorphism. There was significant difference in the frequency of the His/His variant genotype (OR 1.95, 95% CI = 1.93-3.63, P = 0.04) between cases and controls indicating a probable role of this gene in host viral interactions.
authors.affiliation: Department of Biotechnology, Panjab University, Chandigarh, India. rcsobti@pu.ac.in
authors.forename: Ranbir Chander
authors.initials: RC
authors.lastname: Sobti
authors.forename: Nega
authors.initials: N
authors.lastname: Berhane
authors.forename: Salih Abedule
authors.initials: SA
authors.lastname: Mehedi
authors.forename: Rupinder
authors.initials: R
authors.lastname: Kler
authors.forename: Seyed Ali
authors.initials: SA
authors.lastname: Hosseini
authors.forename: Vijish
authors.initials: V
authors.lastname: Kuttiat
authors.forename: Ajay
authors.initials: A
authors.lastname: Wanchu
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000235:genetics* / Q000635:transmission; D000293:Adolescent; D000328:Adult; D019943:Amino Acid Substitution / Q000235:genetics; D001224:Aspartic Acid / Q000235:genetics; D016022:Case-Control Studies; D004268:DNA-Binding Proteins / Q000235:genetics*; D018450:Disease Progression; D004720:Endonucleases / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006679:HIV Seropositivity / Q000235:genetics*; D015497:HIV-1 / Q000502:physiology*; D006639:Histidine / Q000235:genetics; D006801:Humans; D007194:India; D008297:Male; D017533:Marital Status; D008875:Middle Aged; D009687:Nuclear Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D018454:Spouses; D014157:Transcription Factors / Q000235:genetics*; D055815:Young Adult; D000099250:DNA Excision Repair Protein ERCC-5
chemical_list: D001224:Aspartic Acid; D004268:DNA-Binding Proteins; D004720:Endonucleases; D006639:Histidine; D009687:Nuclear Proteins; D014157:Transcription Factors; D000099250:DNA Excision Repair Protein ERCC-5
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