title: Treatment outcomes and prognostic factors of patients with breast cancer: a retrospective review.
abstract: OBJECTIVE
  To determine overall survival (OS), disease-free survival (DFS), and prognostic factors for survival in patients with invasive breast cancer treated with combined-modality therapy at BMA Medical College and Vajira Hospital.
  
  
  METHODS
  The authors retrospectively analyzed the patient-tumor characteristic and treatment outcomes of 615 patients with invasive breast cancer who were treated in our radiation oncology division between 1997 and 2006. The authors used the Kaplan-Meier method to describe OS and DFS. The authors analyzed associations of patients and tumor characteristics with OS using the log-rank test and Cox proportional hazards models.
  
  
  RESULTS
  The median follow-up time of 60 months, there were 46 loco-regional relapses, 108 distant relapses, and 129 deaths. The 5-year OS and DFS were 77.5% and 73.8%, respectively. The median times to local recurrence (LR) and to distant recurrence (DR) were 23 months (range, 10-67 months) and 24 months (range, 5-91 months). Characteristic statistically significant associated with decreased OS included lymphocascular invasion (LVI), estrogen receptor (ER) and progesterone receptor (PR) status, tumor stage, nodal stage, lymph node involvement > or =20%, and stage of disease.
  
  
  CONCLUSIONS
  Overall, the prognosis of patients with breast cancer was good However the subgroup of patients who presented with LVI, ER, and PR negative, T3-4 stage, N3-nodal stage, lymph node involvement > OR =20%, and higher stage of disease had a poor long-term outcome.
authors.affiliation: Division of Radiation Oncology, Department of Radiology, Bangkok Metropolitan Administration Medical College and Vajira Hospital, Bangkok, Thailand.
authors.forename: Thanatip
authors.initials: T
authors.lastname: Tantivatana
authors.forename: Marisa
authors.initials: M
authors.lastname: Chongthanakorn
authors.forename: Kanisa
authors.initials: K
authors.lastname: Rongsriyam
authors.forename: Kanyarat
authors.initials: K
authors.lastname: Katanyoo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000188:drug therapy / Q000401:mortality* / Q000601:surgery; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D015999:Multivariate Analysis; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D016019:Survival Analysis; D013785:Thailand; D016896:Treatment Outcome