title: Interleukin-8 producing hepatocellular carcinoma with pyrexia.
abstract: We discuss a patient who had poorly differentiated HCC with pyrexia and high CRP in laboratory data, which are not commonly observed in the usual HCC. A 50-year-old man with a history of liver dysfunction was admitted with a chief complaint of a prolonged fever and general fatigue. Preoperative diagnosis was HCC with portal vein tumor thrombus. Posterior segmentectomy of the liver and thrombectomy was performed. Rapid tumor recurrence occurred after surgery, and he died 79 days after the operation. Immunohistochemical stain of HCC in this patient revealed the production of proinflammatory cytokine, interleukin-8 (IL-8). IL-8 production may have contributed to the high fever, high inflammatory reaction, and poor prognosis in this case.
authors.affiliation: Department of Surgery, Iizuka Hospital, Fukuoka 820-8505, Japan. nharimotoh1@aih-net.com
authors.forename: Norifumi
authors.initials: N
authors.lastname: Harimoto
authors.forename: Ken
authors.initials: K
authors.lastname: Shirabe
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Abe
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Kajiyama
authors.forename: Takashi
authors.initials: T
authors.lastname: Nagaie
authors.forename: Tomonobu
authors.initials: T
authors.lastname: Gion
authors.forename: Yousuke
authors.initials: Y
authors.lastname: Kuroda
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Maehara
mesh_terms: D002097:C-Reactive Protein / Q000378:metabolism; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D017809:Fatal Outcome; D005334:Fever / Q000209:etiology; D006801:Humans; D007150:Immunohistochemistry; D016209:Interleukin-8 / Q000096:biosynthesis*; D008113:Liver Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D014057:Tomography, X-Ray Computed
chemical_list: D016209:Interleukin-8; D002097:C-Reactive Protein
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