Analysis of central blood pressure during diphtheria intoxication in rabbits.
Diphtheria intoxication was induced in rabbits by a single intravenous injection of native diphtheria toxin in dose of 0.3 MLD/kg, preliminary titrated on guinea pigs. Significant decrease in diastolic and systolic blood pressure and in intraventricular pressure in the left ventricle was established to take place during intoxication. Pulse wave propagation time was prolonged, likely due to prolongation of pressure wave, while the reflection wave appeared at the same time. Reduction of central blood pressure was concluded to result from changes in biomechanical characteristics of the left ventricle, and not to be associated with changes in elastic properties of the arterial wall.
Blagonravov
M L
ML
Department of General Pathology and Pathological Physiology, People's Friendship University of Russia, Moscow, Russia. blagonravovm@mail.ru
Frolov
V A
VA
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D004167:Diphtheria Toxin / Q000633:toxicity*; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects*; D011042:Poisons / Q000494:pharmacology*; D011817:Rabbits; D013997:Time Factors; D016277:Ventricular Function, Left / Q000187:drug effects
D004167:Diphtheria Toxin; D011042:Poisons