title: Association of monocyte chemoattractant protein-1 with adipocyte number, insulin resistance and liver function markers.
abstract: BACKGROUND
  Monocyte chemoattractant protein-1 (MCP-1) is an inflammatory chemokine known to induce adipocyte dedifferentiation and insulin resistance. Inflammation, insulin resistance, and obesity have been implicated in the pathogenesis of non-alcoholic fatty liver disease (NAFLD).
  
  
  METHODS
  Fasting plasma from 43 baboons were assayed for MCP-1, insulin, glucose, alanine aminotransferase (ALT), and aspartate aminotransferase (AST). Adipocyte number and volume were measured via biopsies of omental adipose tissue. The homeostatic model assessment method (HOMA) was used to estimate systemic insulin resistance.
  
  
  RESULTS
  Sex and age adjusted correlations were significant for MCP-1 with adipocyte number (r = -0.42; P = 0.01), adipocyte volume (r = 0.38; P = 0.02), HOMA (r = 0.45; P = 0.004), ALT (r = 0.46; P = 0.03) and AST (r = 0.45; P = 0.03).
  
  
  CONCLUSIONS
  These results suggest that MCP-1 is related with adipocyte dedifferentiation and systemic insulin resistance, thereby potentially contributing to the development of NAFLD.
authors.affiliation: Division of Nutritional Sciences, Department of Human Ecology, The University of Texas at Austin, Austin, TX, USA. tbose@calpoly.edu
authors.forename: Tanushree
authors.initials: T
authors.lastname: Bose
authors.forename: Juan Carlos Lopez
authors.initials: JC
authors.lastname: Alvarenga
authors.forename: M Elizabeth
authors.initials: ME
authors.lastname: Tejero
authors.forename: V Saroja
authors.initials: VS
authors.lastname: Voruganti
authors.forename: J Michael
authors.initials: JM
authors.lastname: Proffitt
authors.forename: Jeanne H
authors.initials: JH
authors.lastname: Freeland-Graves
authors.forename: Shelley A
authors.initials: SA
authors.lastname: Cole
authors.forename: Anthony G
authors.initials: AG
authors.lastname: Comuzzie
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D015415:Biomarkers / Q000097:blood; D018932:Chemokine CCL2 / Q000097:blood*; D005234:Fatty Liver / Q000097:blood / Q000209:etiology* / Q000473:pathology; D005260:Female; D007249:Inflammation / Q000097:blood / Q000150:complications*; D007333:Insulin Resistance; D050152:Intra-Abdominal Fat / Q000473:pathology*; D008111:Liver Function Tests; D008297:Male; D048529:Papio hamadryas
chemical_list: D015415:Biomarkers; D018932:Chemokine CCL2; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase
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