title: Computational design and in vitro characterization of an integrated maglev pump-oxygenator.
abstract: For the need for respiratory support for patients with acute or chronic lung diseases to be addressed, a novel integrated maglev pump-oxygenator (IMPO) is being developed as a respiratory assist device. IMPO was conceptualized to combine a magnetically levitated pump/rotor with uniquely configured hollow fiber membranes to create an assembly-free, ultracompact system. IMPO is a self-contained blood pump and oxygenator assembly to enable rapid deployment for patients requiring respiratory support or circulatory support. In this study, computational fluid dynamics (CFD) and computer-aided design were conducted to design and optimize the hemodynamics, gas transfer, and hemocompatibility performances of this novel device. In parallel, in vitro experiments including hydrodynamic, gas transfer, and hemolysis measurements were conducted to evaluate the performance of IMPO. Computational results from CFD analysis were compared with experimental data collected from in vitro evaluation of the IMPO. The CFD simulation demonstrated a well-behaved and streamlined flow field in the main components of this device. The results of hydrodynamic performance, oxygen transfer, and hemolysis predicted by computational simulation, along with the in vitro experimental data, indicate that this pump-lung device can provide the total respiratory need of an adult with lung failure, with a low hemolysis rate at the targeted operating condition. These detailed CFD designs and analyses can provide valuable guidance for further optimization of this IMPO for long-term use.
authors.affiliation: Artificial Organs Laboratory, Department of Surgery, University of Maryland School of Medicine, 10. S. Pine Street, Baltimore, MD 21201, USA.
authors.forename: Juntao
authors.initials: J
authors.lastname: Zhang
authors.forename: M Ertan
authors.initials: ME
authors.lastname: Taskin
authors.forename: Andrew
authors.initials: A
authors.lastname: Koert
authors.forename: Tao
authors.initials: T
authors.lastname: Zhang
authors.forename: Barry
authors.initials: B
authors.lastname: Gellman
authors.forename: Kurt A
authors.initials: KA
authors.lastname: Dasse
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Gilbert
authors.forename: Bartley P
authors.initials: BP
authors.lastname: Griffith
authors.forename: Zhongjun J
authors.initials: ZJ
authors.lastname: Wu
mesh_terms: D000328:Adult; D000818:Animals; D003198:Computer Simulation; D017076:Computer-Aided Design; D004867:Equipment Design; D015199:Extracorporeal Membrane Oxygenation / Q000009:adverse effects / Q000295:instrumentation*; D006461:Hemolysis; D018056:Hemorheology; D006801:Humans; D008280:Magnetics; D008422:Materials Testing; D010100:Oxygen / Q000097:blood; D010107:Oxygenators, Membrane / Q000009:adverse effects; D011312:Pressure; D012131:Respiratory Insufficiency / Q000097:blood / Q000628:therapy*; D012399:Rotation; D012756:Sheep; D013314:Stress, Mechanical; D013997:Time Factors
chemical_list: D010100:Oxygen