title: Soya protein does not affect glycaemic control in adults with type 2 diabetes.
abstract: Evidence from observational, animal and human studies supports a role for soya protein and its isoflavones in the improvement of glycaemic control in type 2 diabetes. The objective of the present study was to determine the effect of isoflavone-rich soya protein on markers of glycaemic control in adults with type 2 diabetes. Using a randomised, crossover, double-blind, placebo-controlled design, adults with diet-controlled type 2 diabetes (n 29) consumed soya protein isolate (SPI) and milk protein isolate (MPI) for 57 d each separated by a 4-week washout. Blood was collected on days 1 and 57 of each treatment period for analysis of fasting HbA1C, and fasting and postprandial glucose, insulin and calculated indices of insulin sensitivity and resistance. Urine samples of 24 h were collected at the end of each treatment period for analysis of isoflavones. Urinary isoflavone excretion was significantly greater following consumption of SPI compared with MPI, and 20.7 % of the subjects (n 6) were classified as equol excretors. SPI consumption did not significantly affect fasting or postprandial glucose or insulin, fasting HbA1C, or indices of insulin sensitivity and resistance. These data do not support a role for soya protein in the improvement of glycaemic control in adults with diet-controlled type 2 diabetes and contribute to a limited literature of human studies on the effects of soya protein on the management of type 2 diabetes.
authors.affiliation: Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ont., Canada N1G 2W1.
authors.forename: Colleen P
authors.initials: CP
authors.lastname: Gobert
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Pipe
authors.forename: Sarah E
authors.initials: SE
authors.lastname: Capes
authors.forename: Gerarda A
authors.initials: GA
authors.lastname: Darlington
authors.forename: Johanna W
authors.initials: JW
authors.lastname: Lampe
authors.forename: Alison M
authors.initials: AM
authors.lastname: Duncan
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism*; D018592:Cross-Over Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000652:urine; D015930:Diet Records; D004311:Double-Blind Method; D002149:Energy Intake; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006029:Glycosuria; D006801:Humans; D007044:Hysterectomy; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D007529:Isoflavones / Q000652:urine; D008297:Male; D008875:Middle Aged; D008894:Milk Proteins / Q000494:pharmacology; D017698:Postmenopause; D019518:Postprandial Period; D018401:Sample Size; D030262:Soybean Proteins / Q000494:pharmacology*
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007328:Insulin; D007529:Isoflavones; D008894:Milk Proteins; D030262:Soybean Proteins