title: Synthesis and glycogen phosphorylase inhibitory activity of N-(beta-D-glucopyranosyl)amides possessing 1,4-benzodioxane moiety.
abstract: A series of N-(beta-D-glucopyranosyl)amides 5d-i were synthesized by PMe(3) mediated Staudinger reaction of O-peracetylated beta-D-glucopyranosyl azide (1) followed by acylation with carboxylic acids 3d-i and subsequent Zemplén deacetylation. The new compounds were tested for their inhibitory activity against rabbit muscle glycogen phosphorylase and the structure-activity relationships of these compounds are also discussed in this paper.
authors.affiliation: Department of Organic Chemistry, University of Debrecen, H-4010 Debrecen, PO Box 20, Hungary.
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Czakó
authors.forename: László
authors.initials: L
authors.lastname: Juhász
authors.forename: Agnes
authors.initials: A
authors.lastname: Kenéz
authors.forename: Katalin
authors.initials: K
authors.lastname: Czifrák
authors.forename: László
authors.initials: L
authors.lastname: Somsák
authors.forename: Tibor
authors.initials: T
authors.lastname: Docsa
authors.forename: Pál
authors.initials: P
authors.lastname: Gergely
authors.forename: Sándor
authors.initials: S
authors.lastname: Antus
mesh_terms: D000577:Amides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D000818:Animals; D004146:Dioxanes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D024982:Glycogen Phosphorylase, Muscle Form / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D015394:Molecular Structure; D011817:Rabbits; D013329:Structure-Activity Relationship
chemical_list: D000577:Amides; D004146:Dioxanes; D024982:Glycogen Phosphorylase, Muscle Form