An association between floor vacuuming and dust-mite and serum eosinophil cationic protein in young asthmatics.
Although vacuum cleaning is recommended to reduce allergen levels and improve asthma and allergic rhinitis symptoms, some studies suggest it may increase allergen load in homes. We conducted a cross-sectional study to determine if home floor vacuuming was associated with sensitization to dust-mites and cockroaches, and serum eosinophil cationic protein (ECP), a biomarker for atopy, in 102 physician-diagnosed spirometry-confirmed asthmatics. We collected data on floor type, floor cleaning method and frequency, asthma severity, allergy medications used, serum ECP and skin prick tests (SPT) to three dust-mites [Dermatophagoides pteronyssisinus (Der p), Dermatophagoides farinae (Der f) and Blomia tropicalis (Blo t)] and two cockroaches [Periplanata americana (Per a) and Blatella germanica (Bla g)]. Those who vacuumed had increased sensitization to three dust-mites [adjusted ORs (95%CI) = Der p: 26.6 (1.8-405.2); Der f: 44.8 (3.2-620.9); Blo t: 14.1 (1.8-108.1)] but not to cockroaches, adjusted for cleaning frequency and other methods of floor cleaning. Subjects who vacuumed their floor had higher levels of serum ECP than those who did not [adjusted median difference (95%CI): 9.4 (1.1-17.7)], adjusted for use of nasal corticosteroids among those with allergic rhinitis. Vacuuming is associated with increased sensitization to dust-mite allergens and higher serum ECP.


CONCLUSIONS
We found an association between floor vacuuming and increased sensitization to dust-mite allergens and higher levels of an atopy biomarker. Current recommendations to use vacuuming to control allergen exposure and allergic conditions may need to be reconsidered until further studies are performed.
Koh
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GC
Department of Epidemiology and Public Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. ephkohch@nus.edu.sg
Shek
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Kee
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Tai
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Wee
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Ng
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Koh
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D000293:Adolescent; D000818:Animals; D001249:Asthma / Q000097:blood / Q000276:immunology / Q000517:prevention & control*; D020048:Blattellidae / Q000276:immunology*; D002648:Child; D003430:Cross-Sectional Studies; D040001:Dermatophagoides farinae / Q000276:immunology*; D040002:Dermatophagoides pteronyssinus / Q000276:immunology*; D047150:Eosinophil Cationic Protein / Q000097:blood*; D005260:Female; D006798:Housing; D006801:Humans; D008297:Male; D010526:Periplaneta / Q000276:immunology*; D014618:Vacuum
D047150:Eosinophil Cationic Protein