title: Role of LINC proteins in plant nuclear morphology.
abstract: A common fate of post-mitotic interphase plant nuclei is morphological differentiation into an array of shapes and sizes. Development of nuclear morphology occurs in a cell-specific manner and is influenced by cell shape and nuclear DNA content. The LINC (LITTLE NUCLEI) proteins are plant-specific nuclear coiled-coil proteins that appear to couple nuclear development to cellular (shape) and nuclear (DNA content) cues. linc mutations cause a variety of defects, including smaller more spherical nuclei and whole-plant dwarfing. Supplementing our previous results, we constructed transgenic plants expressing LINC1-GFP from the native promoter and found that LINC1 is predominantly expressed in proliferating tissues. Moreover, LINC1-GFP signal was found to be concentrated at the nuclear periphery. These results suggest that LINC1 plays an important structural role at an early stage in nuclear development.
authors.affiliation: Department of Biology; Washington University; St. Louis, Missouri USA.
authors.forename: Travis A
authors.initials: TA
authors.lastname: Dittmer
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Richards
references.citation: Plant Physiol. 1991 Jul;96(3):985-9
references.pmid: 16668285
references.citation: Planta. 2004 Jan;218(3):327-36
references.pmid: 14610677
references.citation: Nat Rev Mol Cell Biol. 2005 Jan;6(1):21-31
references.pmid: 15688064
references.citation: Plant J. 1998 Dec;16(6):735-43
references.pmid: 10069079
references.citation: Mol Biol Cell. 2000 Aug;11(8):2733-41
references.pmid: 10930466
references.citation: Genes Dev. 2002 Mar 1;16(5):533-47
references.pmid: 11877373
references.citation: Plant Physiol. 2004 Mar;134(3):927-39
references.pmid: 15020757
references.citation: Mol Biol Cell. 2004 Jun;15(6):2664-73
references.pmid: 15034145
references.citation: J Exp Bot. 2007;58(1):27-34
references.pmid: 16804054
references.citation: Exp Cell Res. 1997 Apr 10;232(1):173-81
references.pmid: 9141634
references.citation: Int Rev Cytol. 2003;226:1-62
references.pmid: 12921235
references.citation: Curr Opin Plant Biol. 2003 Dec;6(6):544-53
references.pmid: 14611952
references.citation: Plant Physiol. 2003 Oct;133(2):462-9
references.pmid: 14555774
references.citation: Plant Cell. 2007 Sep;19(9):2793-803
references.pmid: 17873096