title: Prognostic value of coronary revascularisation-related myocardial injury: a cardiac magnetic resonance imaging study.
abstract: OBJECTIVE
  Myocardial revascularisation improves outcomes in patients with coronary artery disease. However, these procedures may themselves cause irreversible myocardial injury. The prognostic value of procedural myocardial injury is uncertain.
  
  
  RESULTS
  We quantified procedural myocardial necrosis using delayed enhancement cardiovascular magnetic resonance imaging (DE-CMR) in 152 consecutive patients before and shortly after percutaneous coronary intervention (PCI) or coronary artery bypass graft (CABG). The primary endpoint was defined as death, non-fatal myocardial infarction, sustained ventricular arrhythmia, unstable angina or heart failure requiring hospitalisation. During a median follow-up of 2.9 years, 27 patients (18%) reached the primary endpoint. 49 patients (32%) had evidence of new procedure-related myocardial hyperenhancement with a median mass of 5.0 g (interquartile range 2.7-9.8). After adjustment for age and sex, these patients had a 3.1-fold (95% confidence interval 1.4 to 6.8; p = 0.004) higher risk of adverse outcome than patients without new hyperenhancement. Cardiac troponin levels and quantitative measures of left ventricular function after procedure did not show any significant independent association with the primary endpoint and they did not alter the independent association of new hyperenhancement.
  
  
  CONCLUSIONS
  Myocardial injury during PCI or CABG, identified by DE-CMR, adversely affects clinical outcome. This suggests the benefits from revascularisation could partially be offset by new myocardial injury caused by the intervention itself.
authors.affiliation: University of Oxford, Clinical Trial Service Unit and Epidemiological Studies Unit, Oxford, UK.
authors.forename: K
authors.initials: K
authors.lastname: Rahimi
authors.forename: A P
authors.initials: AP
authors.lastname: Banning
authors.forename: A S H
authors.initials: AS
authors.lastname: Cheng
authors.forename: T J
authors.initials: TJ
authors.lastname: Pegg
authors.forename: T D
authors.initials: TD
authors.lastname: Karamitsos
authors.forename: K M
authors.initials: KM
authors.lastname: Channon
authors.forename: S
authors.initials: S
authors.lastname: Darby
authors.forename: D P
authors.initials: DP
authors.lastname: Taggart
authors.forename: S
authors.initials: S
authors.lastname: Neubauer
authors.forename: J B
authors.initials: JB
authors.lastname: Selvanayagam
mesh_terms: D054058:Acute Coronary Syndrome / Q000401:mortality / Q000628:therapy*; D000787:Angina Pectoris / Q000401:mortality / Q000628:therapy*; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects* / Q000401:mortality; D001026:Coronary Artery Bypass / Q000009:adverse effects* / Q000401:mortality; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D018810:Magnetic Resonance Angiography / Q000379:methods / Q000401:mortality; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis / Q000401:mortality / Q000628:therapy; D015428:Myocardial Reperfusion Injury / Q000175:diagnosis* / Q000209:etiology / Q000401:mortality; D011379:Prognosis