Functional connectivity delineates distinct roles of the inferior frontal cortex and presupplementary motor area in stop signal inhibition.
The neural basis of motor response inhibition has drawn considerable attention in recent imaging literature. Many studies have used the go/no-go or stop signal task to examine the neural processes underlying motor response inhibition. In particular, showing greater activity during no-go (stop) compared with go trials and during stop success compared with stop error trials, the right inferior prefrontal cortex (IFC) has been suggested by numerous studies as the cortical area mediating response inhibition. Many of these same studies as well as others have also implicated the presupplementary motor area (preSMA) in this process, in accord with a function of the medial prefrontal cortex in goal-directed action. Here we used connectivity analyses to delineate the roles of IFC and preSMA during stop signal inhibition. Specifically, we hypothesized that, as an integral part of the ventral attention system, the IFC responds to a stop signal and expedites the stop process in the preSMA, the primary site of motor response inhibition. This hypothesis predicted that preSMA and primary motor cortex would show functional interconnectivity via the basal ganglia circuitry to mediate response execution or inhibition, whereas the IFC would influence the basal ganglia circuitry via connectivity with preSMA. The results of Granger causality analyses in 57 participants confirmed this hypothesis. Furthermore, psychophysiological interaction showed that, compared with stop errors, stop successes evoked greater effective connectivity between the IFC and preSMA, providing additional support for this hypothesis. These new findings provided evidence critically differentiating the roles of IFC and preSMA during stop signal inhibition and have important implications for our understanding of the component processes of inhibitory control.
Duann
Jeng-Ren
JR
Swartz Center for Computational Neuroscience, Institute of Neural Computation, University of California, San Diego, 92093, USA.
Ide
Jaime S
JS
Luo
Xi
X
Li
Chiang-shan Ray
CS
D000328:Adult; D001479:Basal Ganglia / Q000502:physiology; D001931:Brain Mapping; D005260:Female; D005625:Frontal Lobe / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000502:physiology; D009434:Neural Pathways / Q000502:physiology; D009483:Neuropsychological Tests; D011597:Psychomotor Performance / Q000502:physiology*; D011601:Psychophysics; D011930:Reaction Time; D013647:Task Performance and Analysis; D055815:Young Adult
Nat Rev Neurosci. 2008 Nov;9(11):856-69
18843271
Nat Rev Neurosci. 2002 Mar;3(3):201-15
11994752
Neuroscientist. 2007 Dec;13(6):580-93
17911216
J Acoust Soc Am. 1971 Feb;49(2):Suppl 2:467+
5541744
Neuroimage. 2008 Sep 1;42(3):1196-206
18588986
Neuroimage. 2003 Sep;20(1):351-8
14527595
Biol Cybern. 2000 Jul;83(1):35-45
10933236
Nat Neurosci. 1999 Apr;2(4):370-4
10204545
Neuron. 2007 Jun 7;54(5):697-711
17553420
Nat Neurosci. 1998 May;1(1):17-22
10195103
Neuroimage. 2009 Aug 15;47(2):442-50
19442752
J Sleep Res. 2007 Dec;16(4):381-7
18036083
Psychol Rev. 2014 Jan;121(1):66-95
24490789
J Neurophysiol. 1998 Feb;79(2):1070-80
9463462
Neural Comput. 2007 Apr;19(4):910-33
17348767
Neuroimage. 2002 Apr;15(4):870-8
11906227
Neuropsychologia. 2008 Jan 15;46(1):224-32
17850833
Hum Brain Mapp. 2001 Mar;12(3):131-43
11170305
Cogn Affect Behav Neurosci. 2009 Mar;9(1):103-12
19246331
J Neurosci. 2008 Mar 26;28(13):3341-9
18367601
Brain Res. 2007 Feb 9;1132(1):139-47
17173869
Hum Brain Mapp. 2009 Apr;30(4):1361-73
18537116
Neuroimage. 2002 Jan;15(1):273-89
11771995
Drug Alcohol Depend. 2006 Dec 1;85(3):205-12
16725282
Science. 2004 Feb 20;303(5661):1208-10
14976320
Psychol Med. 2009 Jun;39(6):907-16
18796175
Biol Cybern. 2001 Aug;85(2):145-57
11508777
Neurosci Biobehav Rev. 2008;32(1):123-42
17706781
Psychol Med. 2005 Jun;35(6):807-16
15997601
Proc Natl Acad Sci U S A. 1996 Aug 6;93(16):8694-8
8710933
Trends Cogn Sci. 2008 Nov;12(11):418-24
18799345
Magn Reson Imaging. 2006 Feb;24(2):181-5
16455407
Neurosci Biobehav Rev. 2008;32(3):581-97
18164058
Magn Reson Imaging. 2003 Dec;21(10):1251-61
14725933
Neuroimage. 2007 Oct 1;37(4):1354-61
17681798
Psychol Sci. 2005 Feb;16(2):114-22
15686577
Neuroimage. 1997 Oct;6(3):218-29
9344826
Biol Psychiatry. 2009 Jan 1;65(1):39-45
18723163
Neuron. 2008 May 8;58(3):306-24
18466742
Neuroimage. 2001 May;13(5):903-19
11304086
J Neurol Neurosurg Psychiatry. 2004 Apr;75(4):539-44
15026491
Neuroimage. 2007;36 Suppl 2:T155-63
17499162
Hum Brain Mapp. 2009 Feb;30(2):452-61
18064582
J Cogn Neurosci. 2008 Jun;20(6):1021-9
18211230
Nat Neurosci. 2007 Feb;10(2):240-8
17237780
J Neurosci. 2005 May 4;25(18):4593-604
15872107
Neuroreport. 2000 Feb 7;11(2):271-7
10674469
Curr Biol. 2005 Jan 26;15(2):122-8
15668167
Hum Brain Mapp. 2009 Sep;30(9):2971-85
19172643
J Neurosci. 2006 Mar 1;26(9):2424-33
16510720
Trends Cogn Sci. 2007 Dec;11(12):535-43
17997124
Dev Psychol. 1999 Jan;35(1):205-13
9923475
Hum Brain Mapp. 2007 Dec;28(12):1347-58
17274022
Neuroscientist. 2005 Dec;11(6):563-76
16282597
Neuroimage. 2008 Jul 15;41(4):1352-63
18485743
Hum Brain Mapp. 2001 Feb;12(2):100-9
11169874
Biol Psychiatry. 2005 Jun 1;57(11):1273-84
15949999
Proc Natl Acad Sci U S A. 1999 Jul 6;96(14):8301-6
10393989
Hum Brain Mapp. 1999;7(4):254-66
10408769
J Neurosci. 2007 Oct 10;27(41):11091-102
17928451
Nat Neurosci. 2006 Jul;9(7):925-31
16732274
Neuropsychology. 2003 Apr;17(2):272-82
12803433
Neuroimage. 2006 May 15;31(1):187-96
16434214
J Cogn Neurosci. 2008 Mar;20(3):478-93
18004945
Neuroimage. 2002 May;16(1):217-40
11969330
Neuroimage. 2001 Feb;13(2):250-61
11162266
Neuroimage. 2003 Aug;19(4):1602-11
12948715
IEEE Trans Biomed Eng. 2004 Sep;51(9):1501-10
15376498
Neuroimage. 2003 May;19(1):200-7
12781739
Neuroimage. 2002 Dec;17(4):1820-9
12498755
Cereb Cortex. 1999 Dec;9(8):815-23
10601000
Neuroscience. 2008 Sep 9;155(4):1142-51
18674592
J Neurosci. 2007 Sep 12;27(37):9893-900
17855604
Neuroimage. 2004 Jun;22(2):530-40
15193581
Psychol Med. 2006 Apr;36(4):495-505
16336744
Br J Psychiatry. 2009 Feb;194(2):123-9
19182173
Neuroimage. 2008 May 1;40(4):1807-14
18329290
J Abnorm Child Psychol. 2007 Oct;35(5):745-58
17668315
Eur J Neurosci. 2005 Jul;22(1):225-34
16029212
Am J Psychiatry. 2005 Jun;162(6):1067-75
15930054
Cereb Cortex. 2008 Aug;18(8):1923-32
18245044
BMC Neurosci. 2009 Jul 14;10:75
19602259
J Neurosci. 2007 Aug 22;27(34):9141-5
17715350
J Exp Psychol Hum Percept Perform. 1990 Feb;16(1):164-182
2137517
Dev Neuropsychol. 2002;21(1):93-111
12058837
Curr Psychiatry Rep. 2005 Mar;7(1):65-72
15717989
Cereb Cortex. 2009 Jan;19(1):146-52
18445602
J Neurophysiol. 2002 May;87(5):2577-92
11976394
Neuroimage. 2008 Feb 1;39(3):1356-69
18024158
Neuroimage. 2005 Mar;25(1):230-42
15734358
J Neurosci. 2006 Jan 4;26(1):186-92
16399686
Child Neuropsychol. 2000 Sep;6(3):175-84
11402395
Brain. 1999 May;122 ( Pt 5):981-91
10355680