title: Correlation of hepatic venous pressure gradient with variceal bleeding, size of esophageal varices, etiology, ascites and degree of liver dysfunction in cirrhosis of liver.
abstract: An elevated hepatic venous pressure gradient (HVPG) has been associated with risk of variceal bleeding, and outcome and survival after variceal bleeding. In this pilot study, we measured HVPG in 40 patients with liver cirrhosis and studied its relationship with etiology of liver disease, esophageal variceal size, history of variceal bleeding or ascites, biochemical liver tests and Child-Pugh class. There was no procedurerelated complication. The mean (SD) HVPG was similar in patients who had history of variceal bleeding as compared to those who did not (15.4 [2.8] mmHg vs. 13.9 [2.7] mmHg, p=0.1); HVPG had no significant association with etiology of cirrhosis (p=0.4). HVPG levels were significantly higher in patients with larger esophageal varices (grade III/IV vs. I/II: 15.2 [2.7] mmHg vs.13.1 [2.8] mmHg, p=0.04), poorer Child-Pugh class (B or C versus A), and presence of ascites (p=0.04). Thus, HVPG correlated with variceal size, Child-Pugh class, and presence of ascites, but not with variceal bleeding status.
authors.affiliation: Department of Gastroenterology, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, 190 011, India.
authors.forename: Ghulam Mohamad
authors.initials: GM
authors.lastname: Gulzar
authors.forename: Showkat Ali
authors.initials: SA
authors.lastname: Zargar
authors.forename: Sheikh
authors.initials: S
authors.lastname: Jalal
authors.forename: Mohamad Sultan
authors.initials: MS
authors.lastname: Alaie
authors.forename: Gul
authors.initials: G
authors.lastname: Javid
authors.forename: Pawan Kumar
authors.initials: PK
authors.lastname: Suri
authors.forename: Nisar Ahmad
authors.initials: NA
authors.lastname: Shah
authors.lastname: Bilal-Ul-Rehman
authors.forename: Mohamad Shafi
authors.initials: MS
authors.lastname: Hakeem
authors.forename: Abid
authors.initials: A
authors.lastname: Shoukat
authors.forename: Gulzar Ahmad
authors.initials: GA
authors.lastname: Dar
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001201:Ascites / Q000209:etiology* / Q000503:physiopathology; D002405:Catheterization, Central Venous; D016099:Endoscopy, Gastrointestinal; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications* / Q000503:physiopathology; D017093:Liver Failure / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology*; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011379:Prognosis; D012189:Retrospective Studies; D012720:Severity of Illness Index; D014690:Venous Pressure / Q000502:physiology*; D055815:Young Adult
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