title: Cycloartane triterpenes from dikamali, the gum resin of Gardenia gummifera and Gardenia lucida.
abstract: We report on the chemical investigation of dikamali gum, which is the resin of Gardenia gummifera and G. lucida (Rubiaceae). Six new cycloartane triterpenes, dikamaliartanes A-F (1-6, resp.), together with a known flavonoid (7), were isolated and identified by NMR spectroscopy. All six cycloartanes are characterized by an open A-ring with a free COOH group at C(3). In four of them, the C-atoms C(23)-C(27) form a 4-methylfuran-2-yl moiety. Bacterial assays using Staphylococcus aureus, Candida albicans, and Mycobacteria have been carried out but did not reveal significant activity.
authors.affiliation: Institute of Pharmaceutical Sciences, Karl-Franzens-University Graz, Graz.
authors.forename: Olaf
authors.initials: O
authors.lastname: Kunert
authors.forename: Gandhe
authors.initials: G
authors.lastname: Sreekanth
authors.forename: Gummadi Sreedhar
authors.initials: GS
authors.lastname: Babu
authors.forename: Belvotagi Venkat Rao Adavi
authors.initials: BV
authors.lastname: Rao
authors.forename: Marupaka
authors.initials: M
authors.lastname: Radhakishan
authors.forename: Bobbala Ravi
authors.initials: BR
authors.lastname: Kumar
authors.forename: Robert
authors.initials: R
authors.lastname: Saf
authors.forename: Achanta Venkata Narasimha Appa
authors.initials: AV
authors.lastname: Rao
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Schühly
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D032062:Gardenia / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D053149:Plant Gums / Q000737:chemistry*; D012116:Resins, Plant / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D053149:Plant Gums; D012116:Resins, Plant; D014315:Triterpenes