title: Reference values of urinary neutrophil gelatinase-associated lipocalin in very low birth weight infants.
abstract: In very low birth weight (VLBW) infants, acute renal impairment (ARI) is common, but there is no consensus about criteria for its diagnosis. Neutrophil gelatinase-associated lipocalin (NGAL) is an early and sensitive indicator of renal impairment in experimental animals, children, and adults. Urinary NGAL (UNGAL) is detectable in VLBW infants; however, there is no reference range in this population. The objective of this study is to define the reference range for UNGAL in VLBW infants with no risk factors for acute renal impairment. UNGAL concentration was determined in urine samples collected from day of life (DOL) 4 through DOL 30 in 50 newborns with uncomplicated clinical courses, selected from a total of 145 prospectively enrolled appropriate for gestational age inborn VLBW premature infants. The birth weight and gestational age ranges were 790-1490 g and 26-33 wk, respectively. The median, 95th and 99th percentiles, and range of pooled UNGAL values were 5 ng/mL, 50 ng/mL, 120 ng/mL, and 2-150 ng/mL, respectively. Greater variability and higher quantile levels of UNGAL were observed in females versus males. In conclusion, a reference range for UNGAL in VLBW infants, similar to that in children and adults, has been established.
authors.affiliation: Division of Newborn Medicine, Department of Pediatrics, New York Presbyterian Hospital-Weill Cornell Medical College, New York, New York 10065, USA. trangkhuynh@yahoo.com
authors.forename: Trang K
authors.initials: TK
authors.lastname: Huynh
authors.forename: David A
authors.initials: DA
authors.lastname: Bateman
authors.forename: Elvira
authors.initials: E
authors.lastname: Parravicini
authors.forename: John M
authors.initials: JM
authors.lastname: Lorenz
authors.forename: Sheri L
authors.initials: SL
authors.lastname: Nemerofsky
authors.forename: Meghan E
authors.initials: ME
authors.lastname: Sise
authors.forename: Teresa M
authors.initials: TM
authors.lastname: Bowman
authors.forename: Elena
authors.initials: E
authors.lastname: Polesana
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Barasch
mesh_terms: D000209:Acute-Phase Proteins / Q000652:urine*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight / Q000652:urine*; D007674:Kidney Diseases / Q000175:diagnosis / Q000652:urine; D000071068:Lipocalin-2; D054834:Lipocalins / Q000652:urine*; D008297:Male; D011446:Prospective Studies; D011518:Proto-Oncogene Proteins / Q000652:urine*; D012016:Reference Values; D012044:Regression Analysis; D012307:Risk Factors; D012737:Sex Factors; D013997:Time Factors
chemical_list: D000209:Acute-Phase Proteins; C489506:LCN2 protein, human; D000071068:Lipocalin-2; D054834:Lipocalins; D011518:Proto-Oncogene Proteins
references.citation: J Clin Invest. 2005 Mar;115(3):610-21
references.pmid: 15711640
references.citation: Pediatr Nephrol. 2007 Dec;22(12):2089-95
references.pmid: 17874137
references.citation: Am J Nephrol. 2004 May-Jun;24(3):307-15
references.pmid: 15148457
references.citation: Pediatr Nephrol. 2000 Sep;14(10-11):1037-44
references.pmid: 10975322
references.citation: Anesthesiology. 2006 Sep;105(3):485-91
references.pmid: 16931980
references.citation: Pediatrics. 1999 Apr;103(4):e49
references.pmid: 10103341
references.citation: Stat Med. 2000 Nov 30;19(22):3109-25
references.pmid: 11113946
references.citation: Am J Perinatol. 2009 Jun;26(6):437-40
references.pmid: 19263333
references.citation: Biol Neonate. 2004;86(3):212-6
references.pmid: 15249758
references.citation: J Am Soc Nephrol. 2004 Dec;15(12):3073-82
references.pmid: 15579510
references.citation: Lancet. 2005 Apr 2-8;365(9466):1231-8
references.pmid: 15811456
references.citation: Crit Care. 2007;11(4):R84
references.pmid: 17678545
references.citation: Mol Cell. 2002 Nov;10(5):1045-56
references.pmid: 12453413
references.citation: Pediatr Nephrol. 2000 Nov;15(1-2):119-24
references.pmid: 11095027
references.citation: Am J Physiol Renal Physiol. 2003 Jul;285(1):F9-18
references.pmid: 12788784
references.citation: J Am Soc Nephrol. 2007 Feb;18(2):407-13
references.pmid: 17229907
references.citation: Pediatr Res. 2008 Oct;64(4):423-8
references.pmid: 18552711
references.citation: Pediatr Nephrol. 2006 Jul;21(7):989-94
references.pmid: 16773412
references.citation: Am J Transplant. 2006 Jul;6(7):1639-45
references.pmid: 16827865
references.citation: Arthritis Rheum. 2006 Aug;54(8):2577-84
references.pmid: 16868980
references.citation: Mol Cell. 2002 Nov;10(5):1033-43
references.pmid: 12453412
references.citation: J Biol Chem. 2005 Mar 4;280(9):7875-82
references.pmid: 15637066
references.citation: Pediatr Nephrol. 2000 Mar;14(3):227-39
references.pmid: 10752764
references.citation: Pediatr Nephrol. 2006 Jun;21(6):856-63
references.pmid: 16528543
references.citation: Arch Dis Child Fetal Neonatal Ed. 1995 Nov;73(3):F187-92
references.pmid: 8535880
references.citation: J Am Soc Nephrol. 2003 Oct;14(10):2534-43
references.pmid: 14514731
references.citation: Mol Genet Metab. 2003 Dec;80(4):365-76
references.pmid: 14654349
references.citation: Curr Opin Nephrol Hypertens. 2006 Jul;15(4):442-9
references.pmid: 16775460
references.citation: Pediatrics. 1999 Dec;104(6):e76
references.pmid: 10586010