title: Multi-focal cerebral oligoastrocytoma in a puppy.
abstract: A nine-month-old puppy was presented for investigation of seizures. Neurological deficits were found localising to the prosencephalon, mesencephalon and myelencephalon. Magnetic resonance imaging identified multiple, large lesions involving both cerebral hemispheres. Management with antiepileptic and immunomodulatory drugs was instituted; however, the seizures became progressively refractory and the puppy was euthanased. Histopathology following post-mortem examination found a mixed glial cell tumour with discrete areas where neoplastic cells appeared oligodendroglial or astrocytic. Primary intracranial neoplasia is a rare cause of neurological disease in young dogs. Moreover, this case is unusual in terms of both the mixed glial nature of the neoplasm and also its multi-focal distribution.
authors.affiliation: Department of Veterinary Clinical Sciences, Royal Veterinary College, Hawkshead Lane, North Mymms, Herts, UK.
authors.forename: G L
authors.initials: GL
authors.lastname: Walmsley
authors.forename: K
authors.initials: K
authors.lastname: Chandler
authors.forename: E S
authors.initials: ES
authors.lastname: Davies
authors.forename: C R
authors.initials: CR
authors.lastname: Lamb
authors.forename: B
authors.initials: B
authors.lastname: Smyth
authors.forename: B A
authors.initials: BA
authors.lastname: Summers
mesh_terms: D000818:Animals; D001254:Astrocytoma / Q000473:pathology / Q000662:veterinary*; D001932:Brain Neoplasms / Q000473:pathology / Q000662:veterinary*; D004285:Dogs; D008279:Magnetic Resonance Imaging; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000473:pathology / Q000662:veterinary*; D012640:Seizures / Q000662:veterinary