Acquired factor VIII inhibitors: case reports of paclitaxel and penicillin-induced entities.
Acquired hemophilia A is an uncommon but potentially life-threatening clinical entity mediated by specific autoantibodies direct against coagulation factor VIII. It may be associated with a number of conditions such as solid malignancies, autoimmune diseases, lymphoproliferative disorders, and drugs. Early recognition of this entity is necessary to avoid a delay in treatment, which might lead to serious complications including severe bleeding and death. Hereby, we report a case of acquired hemophilia A caused by a commonly used drug, penicillin, as well as the first reported case, to our knowledge, of acquired Factor VIII inhibitor secondary to paclitaxel.
El-Osta
Hazem
H
University of Kansas School of Medicine, Wichita, KS, USA.
Reddy
Pavan
P
Deutsch
Jeremy M
JM
D000368:Aged; D000369:Aged, 80 and over; D001323:Autoantibodies / Q000097:blood; D005169:Factor VIII / Q000276:immunology*; D005260:Female; D006467:Hemophilia A / Q000139:chemically induced*; D006801:Humans; D008297:Male; D017239:Paclitaxel / Q000009:adverse effects* / Q000627:therapeutic use; D010406:Penicillins / Q000009:adverse effects* / Q000627:therapeutic use; D016896:Treatment Outcome
D001323:Autoantibodies; D010406:Penicillins; D005169:Factor VIII; D017239:Paclitaxel