title: Recent advances in our understanding of neurodegeneration.
abstract: Neurodegenerative diseases are featured by progressive dysfunction and death of cells in selected areas in the nervous system, determining clinical presentation. Neuronal loss is associated with conformational changes in proteins that result in extra- and intra-cellular accumulation of misfolded proteins, representing the hallmarks of many neurodegenerative disorders, summarized as proteinopathies. Intermediate forms such as oligomers and protofibrils are thought to have cytotoxic effects to neurons. Major basic processes, caused by genetic, environmental, and endogenous factors, in addition to abnormal protein dynamics with defective degradation due to deficiency of the ubiquitin-proteosomal-autophagy system, include oxidative stress and free radical formation, impaired bioenergetics and mitochondrial dysfunction, disruption of neuronal Golgi apparatus and transport, molecular chaperones, neurotrophins and "neuroinflammatory" processes. These mechanisms are interrelated in vicious circles finally leading to programmed cell death. A common feature of these conditions is a long run until sufficient protein accumulates, followed by a cascade of symptoms over many years with increasing disability leading to death. This provides a wide therapeutic window, especially in groups at risk identified early and preclinical diagnosis becomes feasible. Neurodegenerative disorders are classified according to known genetic mechanisms or to the major components of protein deposits. Although this has been a productive paradigm for the development of diagnostic consensus criteria, recent molecular biologic and genetic approaches have revealed that there are both overlap and intraindividual diversities between different phenotypes, related to synergistic mechanisms between major pathologic proteins (beta-amyloid, tau, alpha-synuclein, TDP-43), suggesting common pathogenic mechanisms. The nature, time course, and molecular causes of cell degeneration and demise, and the role of various pathogenic factors are a matter of considerable debate, but recent studies have provided insight into the basic processes in neurodegeneration and the roles of cell death programs common to this complex group of disorders, offering new ways for future prevention and treatment strategies.
authors.affiliation: Institute of Clinical Neurobiology, Vienna, Austria. kurt.jellinger@univie.ac.at
authors.forename: Kurt A
authors.initials: KA
authors.lastname: Jellinger
mesh_terms: D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D009154:Mutation / Q000235:genetics; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism; D019636:Neurodegenerative Diseases / Q000145:classification / Q000150:complications / Q000235:genetics / Q000378:metabolism; D018384:Oxidative Stress / Q000502:physiology; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism; D017510:Protein Folding; D025801:Ubiquitin / Q000378:metabolism
chemical_list: D005609:Free Radicals; D009419:Nerve Tissue Proteins; D025801:Ubiquitin; D046988:Proteasome Endopeptidase Complex
references.citation: J Neurochem. 2006 Jun;97(6):1659-75
references.pmid: 16805775
references.citation: Curr Med Chem. 2007;14(28):2968-75
references.pmid: 18220733
references.citation: Curr Opin Neurobiol. 2008 Oct;18(5):504-15
references.pmid: 18840524
references.citation: Mol Neurodegener. 2009 Feb 04;4:9
references.pmid: 19193223
references.citation: Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):19126-31
references.pmid: 16365298
references.citation: Arch Neurol. 2006 May;63(5):649-54
references.pmid: 16682534
references.citation: Am J Pathol. 2005 May;166(5):1283-9
references.pmid: 15855630
references.citation: J Neural Transm (Vienna). 2001;108(12):1397-415
references.pmid: 11810404
references.citation: FEBS J. 2008 Sep;275(17):4252-62
references.pmid: 18637947
references.citation: Bioessays. 2006 Mar;28(3):253-60
references.pmid: 16479581
references.citation: Nat Rev Mol Cell Biol. 2005 Aug;6(8):599-609
references.pmid: 16064136
references.citation: Genes Dev. 2009 Apr 15;23(8):963-74
references.pmid: 19390089
references.citation: J Neurosci. 2005 Mar 9;25(10):2463-70
references.pmid: 15758154
references.citation: Chem Phys Lipids. 2009 Mar;158(1):1-9
references.pmid: 19056366
references.citation: Nat Med. 2004 Oct;10(10):1055-63
references.pmid: 15459709
references.citation: Vitam Horm. 2006;74:505-30
references.pmid: 17027528
references.citation: Ann N Y Acad Sci. 2008 Dec;1147:358-82
references.pmid: 19076457
references.citation: J Neuropathol Exp Neurol. 2008 May;67(5):377-87
references.pmid: 18431258
references.citation: J Cell Mol Med. 2008 Apr;12(2):363-73
references.pmid: 18266959
references.citation: Curr Mol Med. 2008 May;8(3):173-86
references.pmid: 18473818
references.citation: Curr Opin Neurol. 2005 Aug;18(4):357-62
references.pmid: 16003109
references.citation: Brain. 2009 Apr;132(Pt 4):833-42
references.pmid: 19336460
references.citation: Semin Cell Dev Biol. 2007 Dec;18(6):716-31
references.pmid: 18023214
references.citation: Brain Res. 2007 Dec 12;1184:284-94
references.pmid: 17963732
references.citation: Free Radic Biol Med. 2009 Feb 1;46(3):422-9
references.pmid: 19038331
references.citation: Nat Genet. 2006 May;38(5):515-7
references.pmid: 16604074
references.citation: J Neurosci. 2004 Mar 10;24(10):2527-34
references.pmid: 15014128
references.citation: Am J Pathol. 1999 Nov;155(5):1459-66
references.pmid: 10550301
references.citation: Arch Neurol. 2008 Jul;65(7):906-12
references.pmid: 18625856
references.citation: Curr Mol Med. 2008 May;8(3):187-206
references.pmid: 18473819
references.citation: Nat Rev Neurosci. 2008 Nov;9(11):826-38
references.pmid: 18931696
references.citation: Biochim Biophys Acta. 2009 Apr;1793(4):664-73
references.pmid: 18706940
references.citation: Biochemistry. 2009 Mar 10;48(9):1870-7
references.pmid: 19216516
references.citation: Mol Psychiatry. 2009 Mar;14(3):239-51
references.pmid: 18957942
references.citation: Curr Alzheimer Res. 2005 Jan;2(1):3-18
references.pmid: 15977985
references.citation: Science. 2004 Jul 9;305(5681):242-5
references.pmid: 15247478
references.citation: Biochim Biophys Acta. 2008 Dec;1782(12):683-90
references.pmid: 18976704
references.citation: Exp Cell Res. 2008 Mar 10;314(5):950-60
references.pmid: 18255062
references.citation: Science. 2005 Jul 15;309(5733):476-81
references.pmid: 16020737
references.citation: Lancet Neurol. 2008 Sep;7(9):805-11
references.pmid: 18667360
references.citation: J Physiol. 2006 Apr 15;572(Pt 2):477-92
references.pmid: 16469784
references.citation: Acta Neuropathol. 2009 Oct;118(4):505-17
references.pmid: 19360426
references.citation: Neurobiol Dis. 2006 May;22(2):388-400
references.pmid: 16473015
references.citation: Neurodegener Dis. 2008;5(3-4):149-52
references.pmid: 18322375
references.citation: Exp Neurol. 2008 Jan;209(1):5-11
references.pmid: 17603039
references.citation: Annu Rev Biochem. 2009;78:959-91
references.pmid: 19298183
references.citation: Prog Neurobiol. 2007 Feb;81(3):179-96
references.pmid: 17267093
references.citation: Brief Funct Genomic Proteomic. 2006 Mar;5(1):74-86
references.pmid: 16769683
references.citation: Am J Pathol. 2008 Nov;173(5):1488-95
references.pmid: 18818379
references.citation: J Cell Mol Med. 2008 Dec;12(6A):2255-62
references.pmid: 18793350
references.citation: Nat Neurosci. 2005 Dec;8(12):1742-51
references.pmid: 16299504
references.citation: J Clin Invest. 2009 Jan;119(1):13-5
references.pmid: 19104142
references.citation: J Neurosci. 2008 Mar 19;28(12):3051-9
references.pmid: 18354008
references.citation: ScientificWorldJournal. 2008 Apr 20;8:421-33
references.pmid: 18454252
references.citation: Brain Pathol. 2004 Oct;14(4):426-32
references.pmid: 15605990
references.citation: Nature. 2007 Aug 9;448(7154):704-8
references.pmid: 17687326
references.citation: Acta Neuropathol. 2004 Jul;108(1):81-7
references.pmid: 15114487
references.citation: Brain Res Bull. 2005 Apr 30;65(4):275-90
references.pmid: 15811592
references.citation: J Neural Transm Suppl. 2003;(65):101-44
references.pmid: 12946052
references.citation: Science. 2005 Feb 25;307(5713):1282-8
references.pmid: 15731448
references.citation: Neurochem Res. 2009 Apr;34(4):670-8
references.pmid: 18683046
references.citation: J Biol Chem. 2009 May 8;284(19):12845-52
references.pmid: 19282288
references.citation: Neurotoxicol Teratol. 2009 Mar-Apr;31(2):85-8
references.pmid: 19028567
references.citation: Curr Med Chem. 2008;15(1):47-60
references.pmid: 18220762
references.citation: Amino Acids. 2007;32(4):527-34
references.pmid: 17103119
references.citation: J Alzheimers Dis. 2008 Aug;14(4):371-5
references.pmid: 18688086
references.citation: Proc Natl Acad Sci U S A. 2003 Jan 21;100(2):721-6
references.pmid: 12522269
references.citation: Lancet Neurol. 2009 Apr;8(4):382-97
references.pmid: 19296921
references.citation: Proc Natl Acad Sci U S A. 2005 Apr 5;102(14):5215-20
references.pmid: 15784737
references.citation: Brain Pathol. 2008 Jan;18(1):130-8
references.pmid: 18226108
references.citation: Nat Med. 2009 Mar;15(3):331-7
references.pmid: 19198615
references.citation: J Alzheimers Dis. 2006 Sep;10(1):59-73
references.pmid: 16988483
references.citation: Hum Mol Genet. 2009 Apr 15;18(8):1482-8
references.pmid: 19193629
references.citation: PLoS One. 2008 Feb 27;3(2):e1677
references.pmid: 18301754
references.citation: J Neurochem. 2006 Jan;96(1):1-13
references.pmid: 16305625
references.citation: J Neuroinflammation. 2004 Dec 08;1(1):24
references.pmid: 15588287
references.citation: Curr Alzheimer Res. 2006 Apr;3(2):95-108
references.pmid: 16611010
references.citation: J Neurosci. 2008 Jul 2;28(27):6926-37
references.pmid: 18596167
references.citation: Acta Neuropathol. 2006 Sep;112(3):261-5
references.pmid: 16855830
references.citation: IUBMB Life. 2003 Jun;55(6):337-45
references.pmid: 12938736
references.citation: Am J Pathol. 2009 Apr;174(4):1241-51
references.pmid: 19264902
references.citation: J Neurol Sci. 2006 Jul 15;246(1-2):21-30
references.pmid: 16545397
references.citation: Biochim Biophys Acta. 2009 Jan;1792(1):3-13
references.pmid: 19022377
references.citation: Mol Cell. 2009 Feb 27;33(4):517-27
references.pmid: 19250912
references.citation: Biochim Biophys Acta. 2006 Nov-Dec;1762(11-12):1094-108
references.pmid: 16730956
references.citation: Genes Brain Behav. 2008 Feb;7 Suppl 1:92-100
references.pmid: 18184373
references.citation: Neuroreport. 2009 Apr 22;20(6):569-73
references.pmid: 19287320
references.citation: J Neurosci. 2001 Apr 1;21(7):2247-55
references.pmid: 11264300
references.citation: Ann Neurol. 2005 Feb;57(2):168-75
references.pmid: 15668962
references.citation: Proc Natl Acad Sci U S A. 2007 Jul 24;104(30):12524-9
references.pmid: 17636119
references.citation: Mol Neurodegener. 2009 Apr 06;4:16
references.pmid: 19348680
references.citation: J Biol Chem. 2003 Mar 7;278(10):7743-6
references.pmid: 12509422
references.citation: Am J Pathol. 2006 Jan;168(1):184-94
references.pmid: 16400022
references.citation: Nature. 2009 Mar 26;458(7237):453-60
references.pmid: 19325625
references.citation: Curr Alzheimer Res. 2008 Dec;5(6):591-8
references.pmid: 19075586
references.citation: Biochim Biophys Acta. 2006 Nov-Dec;1762(11-12):1038-50
references.pmid: 16876390
references.citation: Proteomics. 2008 Mar;8(6):1221-36
references.pmid: 18283660
references.citation: Methods Mol Biol. 2008;445:1-10
references.pmid: 18425440
references.citation: DNA Repair (Amst). 2009 Apr 5;8(4):491-8
references.pmid: 19213614
references.citation: Br Med Bull. 1997;53(3):451-65
references.pmid: 9374030
references.citation: Exp Neurol. 2008 Apr;210(2):409-20
references.pmid: 18164295
references.citation: Nat Rev Drug Discov. 2004 Mar;3(3):205-14
references.pmid: 15031734
references.citation: Mech Ageing Dev. 2008 Jul-Aug;129(7-8):483-91
references.pmid: 18455751
references.citation: Cell. 2008 Jan 11;132(1):27-42
references.pmid: 18191218
references.citation: J Neuropathol Exp Neurol. 2000 May;59(5):393-7
references.pmid: 10888369
references.citation: Curr Pharm Des. 2007;13(18):1925-8
references.pmid: 17584117
references.citation: FASEB J. 2006 Nov;20(13):2302-12
references.pmid: 17077307
references.citation: Neuroscience. 2009 Feb 6;158(3):1133-42
references.pmid: 19103265
references.citation: Lancet Neurol. 2008 Jan;7(1):97-109
references.pmid: 18093566
references.citation: J Cell Mol Med. 2008 Jun;12(3):762-80
references.pmid: 18363841
references.citation: J Neuropathol Exp Neurol. 2003 Apr;62(4):389-97
references.pmid: 12722831
references.citation: DNA Repair (Amst). 2009 Apr 5;8(4):544-56
references.pmid: 19213613
references.citation: Aging Cell. 2007 Jun;6(3):337-50
references.pmid: 17328689
references.citation: Neurobiol Aging. 2009 Apr;30(4):656-65
references.pmid: 19217189
references.citation: J Mol Biol. 2007 Feb 2;365(5):1337-49
references.pmid: 17134716
references.citation: J Neurosci. 2007 Feb 7;27(6):1405-10
references.pmid: 17287515
references.citation: Hum Mol Genet. 2007 May 15;16(10):1133-42
references.pmid: 17409200
references.citation: Nat Med. 2002 Jun;8(6):600-6
references.pmid: 12042811
references.citation: Hum Mutat. 2006 Jul;27(7):686-95
references.pmid: 16752394
references.citation: J Biol Chem. 2009 Apr 17;284(16):10537-45
references.pmid: 19233847
references.citation: Mol Cell Neurosci. 2009 Mar;40(3):365-73
references.pmid: 19162192
references.citation: Toxicol Pathol. 2007 Jun;35(4):495-516
references.pmid: 17562483
references.citation: Rinsho Shinkeigaku. 2008 Nov;48(11):903-5
references.pmid: 19198112
references.citation: J Neurochem. 2008 Nov;107(3):701-11
references.pmid: 18761710
references.citation: J Biol Chem. 2000 Aug 25;275(34):26096-101
references.pmid: 10846169
references.citation: Cell Mol Life Sci. 2007 Sep;64(17):2245-57
references.pmid: 17604996
references.citation: J Biol Chem. 2004 Oct 1;279(40):42290-301
references.pmid: 15280365
references.citation: Nat Med. 2004 Jul;10 Suppl:S18-25
references.pmid: 15298006
references.citation: J Biol Chem. 2005 Sep 9;280(36):32026-34
references.pmid: 16040601
references.citation: J Neurosci Res. 2004 Jul 1;77(1):1-8
references.pmid: 15197750
references.citation: J Cereb Blood Flow Metab. 2008 Oct;28(10):1754-60
references.pmid: 18575458
references.citation: PLoS Pathog. 2007 Aug 31;3(8):e125
references.pmid: 17784787
references.citation: J Neurosci Res. 2009 Jun;87(8):1884-91
references.pmid: 19185026
references.citation: Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1638-43
references.pmid: 18230723
references.citation: Nat Neurosci. 2005 May;8(5):657-63
references.pmid: 15834418
references.citation: Nature. 2006 Oct 19;443(7113):780-6
references.pmid: 17051204
references.citation: Prog Neurobiol. 2004 Aug;73(5):311-57
references.pmid: 15312912
references.citation: Curr Top Med Chem. 2006;6(6):597-608
references.pmid: 16712494
references.citation: Behav Brain Res. 2008 Sep 1;192(1):106-13
references.pmid: 18359102
references.citation: Neurochem Res. 2009 Apr;34(4):630-8
references.pmid: 19125328
references.citation: Curr Top Dev Biol. 2004;60:17-54
references.pmid: 15094295
references.citation: Am J Pathol. 2002 May;160(5):1655-67
references.pmid: 12000718
references.citation: Novartis Found Symp. 2007;287:183-92; discussion 192-6
references.pmid: 18074639
references.citation: J Neurochem. 2005 Nov;95(4):930-9
references.pmid: 16219024
references.citation: Neurobiol Dis. 2006 May;22(2):323-33
references.pmid: 16406795
references.citation: Sci Signal. 2008 Sep 23;1(38):pe42
references.pmid: 18812565
references.citation: J Neurol. 2008 Sep;255 Suppl 5:3-7
references.pmid: 18787877
references.citation: J Neurochem. 2001 Mar;76(6):1785-93
references.pmid: 11259496
references.citation: Prog Neurobiol. 2008 Jun;85(2):176-93
references.pmid: 18448229
references.citation: Neuron. 2009 Apr 16;62(1):42-52
references.pmid: 19376066
references.citation: Biochim Biophys Acta. 2008 Dec;1782(12):723-9
references.pmid: 18644437
references.citation: Brain Nerve. 2008 Aug;60(8):923-9
references.pmid: 18717196
references.citation: J Neurosci. 2002 Apr 15;22(8):3090-9
references.pmid: 11943812
references.citation: Arch Neurol. 2008 Dec;65(12):1577-81
references.pmid: 19064744
references.citation: Brain Pathol. 2007 Apr;17(2):139-45
references.pmid: 17388944
references.citation: Acta Neuropathol. 2005 Aug;110(2):135-44
references.pmid: 15986225
references.citation: Autophagy. 2008 Apr;4(3):372-4
references.pmid: 18216494
references.citation: Neuron. 2001 Jan;29(1):15-32
references.pmid: 11182078
references.citation: J Neurochem. 2006 Feb;96(3):825-32
references.pmid: 16405502
references.citation: Arch Neurol. 2009 Feb;66(2):190-9
references.pmid: 19204155
references.citation: Science. 2002 Jul 19;297(5580):353-6
references.pmid: 12130773
references.citation: Nat Clin Pract Neurol. 2008 Nov;4(11):600-9
references.pmid: 18978800
references.citation: J Biol Chem. 2004 May 14;279(20):20699-707
references.pmid: 14742431
references.citation: Apoptosis. 2009 Apr;14(4):455-68
references.pmid: 19130231
references.citation: Neuroscience. 2008 Apr 9;152(4):913-23
references.pmid: 18343584
references.citation: Curr Neurol Neurosci Rep. 2009 May;9(3):212-9
references.pmid: 19348710
references.citation: Am J Pathol. 2000 Aug;157(2):401-10
references.pmid: 10934145
references.citation: Acta Neuropathol. 2002 Jul;104(1):1-6
references.pmid: 12070657
references.citation: J Cell Mol Med. 2009 Mar;13(3):412-21
references.pmid: 19374683
references.citation: Oncogene. 2004 Apr 12;23(16):2757-65
references.pmid: 15077139
references.citation: Biochim Biophys Acta. 2008 Dec;1786(2):153-77
references.pmid: 18558098
references.citation: Exp Cell Res. 2007 Apr 15;313(7):1347-60
references.pmid: 17362930
references.citation: Acta Neuropathol. 2006 Feb;111(2):93-100
references.pmid: 16468021
references.citation: Ann Neurol. 2005 Mar;57(3):439-43
references.pmid: 15732111
references.citation: Neurochem Res. 2006 Sep;31(9):1153-62
references.pmid: 16947080
references.citation: FEBS J. 2006 Apr;273(7):1331-49
references.pmid: 16689923
references.citation: Trends Neurosci. 2009 Apr;32(4):199-206
references.pmid: 19268374
references.citation: Neurochem Int. 2002 May;40(6):553-7
references.pmid: 11850112
references.citation: Am J Pathol. 2003 Jul;163(1):91-100
references.pmid: 12819014
references.citation: Int J Dev Neurosci. 2008 Oct;26(6):523-34
references.pmid: 18599251
references.citation: Arch Med Res. 2008 Apr;39(3):265-76
references.pmid: 18279698
references.citation: Int J Mol Sci. 2009 Mar;10(3):1386-406
references.pmid: 19399255
references.citation: Acta Neuropathol. 2009 May;117(5):557-67
references.pmid: 19221770
references.citation: Mol Med. 2008 Jul-Aug;14(7-8):451-64
references.pmid: 18368143
references.citation: Eur J Neurol. 2008 Aug;15(8):772-80
references.pmid: 18684309
references.citation: Neurosignals. 2008;16(1):75-84
references.pmid: 18097162
references.citation: Curr Opin Neurobiol. 2008 Jun;18(3):292-6
references.pmid: 18662781
references.citation: Prog Neurobiol. 2008 Aug;85(4):393-406
references.pmid: 18603345
references.citation: Ann Neurol. 2002 Jun;51(6):779-82
references.pmid: 12112087
references.citation: Ann N Y Acad Sci. 2004 Mar;1012:193-208
references.pmid: 15105267
references.citation: Chem Res Toxicol. 2008 Jan;21(1):172-88
references.pmid: 18052107
references.citation: J Neurochem. 2009 May;109 Suppl 1:153-9
references.pmid: 19393022
references.citation: Int J Mol Sci. 2009 Mar;10(3):1226-60
references.pmid: 19399246
references.citation: Curr Opin Neurobiol. 2007 Oct;17(5):548-55
references.pmid: 17936612
references.citation: Cell Death Differ. 2006 Feb;13(2):285-92
references.pmid: 16123779
references.citation: Neurobiol Dis. 2002 Mar;9(2):244-8
references.pmid: 11895375
references.citation: Mol Brain. 2009 Feb 09;2:5
references.pmid: 19203374
references.citation: Biochim Biophys Acta. 2006 Nov-Dec;1762(11-12):1025-37
references.pmid: 16814528
references.citation: Mol Immunol. 2009 Feb;46(4):695-704
references.pmid: 18930548
references.citation: Antioxid Redox Signal. 2006 Nov-Dec;8(11-12):2061-73
references.pmid: 17034350
references.citation: Ann Pathol. 2005 Sep;25(4):282-91
references.pmid: 16327654
references.citation: Hum Mol Genet. 2005 Feb 15;14(4):463-74
references.pmid: 15615771
references.citation: Biochem J. 2009 Mar 15;418(3):643-50
references.pmid: 19049493
references.citation: FASEB J. 2008 Nov;22(11):3785-94
references.pmid: 18632848
references.citation: J Neural Transm (Vienna). 2004 Mar;111(3):323-45
references.pmid: 14991458
references.citation: Science. 2008 Mar 21;319(5870):1668-72
references.pmid: 18309045
references.citation: Ann Neurol. 2009 Mar;65(3):294-303
references.pmid: 19334058
references.citation: Acta Neuropathol. 2009 Jul;118(1):131-50
references.pmid: 19288120
references.citation: J Neuroinflammation. 2009 Jan 05;6:1
references.pmid: 19123954
references.citation: Int J Biochem Cell Biol. 2009 Oct;41(10):1855-65
references.pmid: 19389487
references.citation: Neuroscientist. 2009 Feb;15(1):47-61
references.pmid: 19218230
references.citation: J Neurobiol. 2004 Feb 5;58(2):258-71
references.pmid: 14704957
references.citation: Methods Enzymol. 2009;453:33-51
references.pmid: 19216901
references.citation: J Neurochem. 2007 Jan;100(1):142-53
references.pmid: 17064354
references.citation: Exp Neurol. 2005 Oct;195(2):484-96
references.pmid: 16085017
references.citation: Nat Rev Neurosci. 2008 Jul;9(7):505-18
references.pmid: 18568013
references.citation: Exp Neurol. 2005 Apr;192(2):244-50
references.pmid: 15755542
references.citation: Biochim Biophys Acta. 2009 Mar;1794(3):375-97
references.pmid: 19071235
references.citation: Lancet Neurol. 2003 Apr;2(4):246-53
references.pmid: 12849213
references.citation: Nature. 2006 Oct 19;443(7113):796-802
references.pmid: 17051206
references.citation: J Biol Chem. 2005 Mar 25;280(12):11648-55
references.pmid: 15659387
references.citation: Science. 2006 Jul 21;313(5785):324-8
references.pmid: 16794039
references.citation: Curr Opin Struct Biol. 2009 Feb;19(1):23-30
references.pmid: 19162471
references.citation: J Biol Chem. 2009 Feb 13;284(7):4398-403
references.pmid: 19074152
references.citation: J Cell Biol. 2005 Oct 10;171(1):87-98
references.pmid: 16203860
references.citation: Nat Rev Mol Cell Biol. 2007 Feb;8(2):101-12
references.pmid: 17245412
references.citation: Brain Res Bull. 2007 Apr 30;72(2-3):148-51
references.pmid: 17352938
references.citation: Hum Mol Genet. 2009 Feb 1;18(3):472-81
references.pmid: 18996918
references.citation: Nat Rev Mol Cell Biol. 2008 Dec;9(12):1004-10
references.pmid: 18971948
references.citation: J Inherit Metab Dis. 2006 Apr-Jun;29(2-3):456-70
references.pmid: 16763918
references.citation: DNA Repair (Amst). 2008 Jul 1;7(7):1110-20
references.pmid: 18463003
references.citation: Neurosci Lett. 2008 Jun 13;438(1):59-63
references.pmid: 18468793
references.citation: Biochemistry. 2008 Oct 7;47(40):10526-39
references.pmid: 18783251
references.citation: Ann Neurol. 2005 Nov;58(5):730-5
references.pmid: 16240347
references.citation: Annu Rev Biochem. 2001;70:503-33
references.pmid: 11395416
references.citation: Prog Neurobiol. 2005 Jun;76(2):77-98
references.pmid: 16081203
references.citation: J Alzheimers Dis. 2009;16(4):833-43
references.pmid: 19387116
references.citation: Nat Rev Neurosci. 2007 Jan;8(1):57-69
references.pmid: 17180163
references.citation: J Clin Invest. 2009 Jan;119(1):182-92
references.pmid: 19104149
references.citation: Biomed Pharmacother. 2004 Jan;58(1):39-46
references.pmid: 14739060
references.citation: J Neural Transm (Vienna). 2006 Nov;113(11):1685-95
references.pmid: 17036175
references.citation: Histochem Cell Biol. 2008 Apr;129(4):407-20
references.pmid: 18320203
references.citation: Science. 2009 Feb 27;323(5918):1205-8
references.pmid: 19251627
references.citation: Neurodegener Dis. 2004;1(1):9-19
references.pmid: 16908969
references.citation: Ann N Y Acad Sci. 2004 Jun;1019:1-4
references.pmid: 15246983
references.citation: Hum Mol Genet. 2003 Apr 1;12(7):749-57
references.pmid: 12651870
references.citation: J Neurosci. 2009 Apr 1;29(13):4004-15
references.pmid: 19339596
references.citation: Ann Neurol. 2009 Jan;65 Suppl 1:S3-9
references.pmid: 19191304
references.citation: Acta Neuropathol. 2006 Sep;112(3):237-51
references.pmid: 16845533
references.citation: Free Radic Biol Med. 2002 Jun 15;32(12):1264-75
references.pmid: 12057764
references.citation: Neuropathol Appl Neurobiol. 2009 Apr;35(2):132-46
references.pmid: 19077110
references.citation: Acta Neuropathol. 2009 Jul;118(1):151-66
references.pmid: 19271225
references.citation: J Neurosci. 2008 Apr 30;28(18):4690-701
references.pmid: 18448646
references.citation: Autophagy. 2008 Feb;4(2):151-75
references.pmid: 18188003
references.citation: Neurobiol Dis. 2003 Dec;14(3):391-403
references.pmid: 14678756
references.citation: Trends Cell Biol. 2009 Apr;19(4):147-55
references.pmid: 19269181
references.citation: J Neuropathol Exp Neurol. 2005 Apr;64(4):280-94
references.pmid: 15835264
references.citation: Acta Neuropathol. 2005 Aug;110(2):101-12
references.pmid: 15983830
references.citation: Brain Pathol. 2009 Jan;19(1):91-107
references.pmid: 18462474
references.citation: J Cell Mol Med. 2009 Apr;13(4):619-30
references.pmid: 19449461
references.citation: Mov Disord. 2006 Nov;21(11):1806-23
references.pmid: 16972273
references.citation: J Mol Biol. 2009 Apr 3;387(3):584-606
references.pmid: 19361429
references.citation: J Cell Biol. 2008 Dec 1;183(5):795-803
references.pmid: 19029340
references.citation: Cell. 2008 Dec 26;135(7):1311-23
references.pmid: 19109899
references.citation: Brain. 2007 Jul;130(Pt 7):1759-66
references.pmid: 17400599
references.citation: Genes Brain Behav. 2008 Feb;7 Suppl 1:43-56
references.pmid: 18184369
references.citation: J Neurosci. 2005 Jun 1;25(22):5446-54
references.pmid: 15930395
references.citation: Neurobiol Dis. 2002 Nov;11(2):341-54
references.pmid: 12505426
references.citation: Annu Rev Pathol. 2006;1:151-70
references.pmid: 18039111
references.citation: Biochim Biophys Acta. 2008 Dec;1782(12):691-9
references.pmid: 18930136
references.citation: Int J Clin Exp Pathol. 2009;2(2):108-18
references.pmid: 19079646
references.citation: J Biol Chem. 2003 Apr 18;278(16):14331-6
references.pmid: 12551935
references.citation: J Alzheimers Dis. 2007 May;11(2):143-52
references.pmid: 17522439
references.citation: Mol Cell Biol. 2009 Apr;29(7):1774-85
references.pmid: 19158272
references.citation: Ann Neurol. 2006 Feb;59(2):315-22
references.pmid: 16437584
references.citation: J Alzheimers Dis. 2008 Jun;14(2):147-59
references.pmid: 18560127
references.citation: Curr Med Chem. 2009;16(5):615-26
references.pmid: 19199926
references.citation: J Alzheimers Dis. 2008 May;13(4):359-69
references.pmid: 18487845
references.citation: Prog Neurobiol. 2009 Feb;87(3):181-94
references.pmid: 19388207
references.citation: Neurology. 2005 Aug 23;65(4):603-5
references.pmid: 16116125
references.citation: J Neurochem. 2003 Sep;86(5):1142-8
references.pmid: 12911622
references.citation: Acta Neuropathol. 2009 Jan;117(1):63-73
references.pmid: 18853169
references.citation: J Neuropathol Exp Neurol. 2006 Jul;65(7):631-41
references.pmid: 16825950
references.citation: Neurology. 2006 Jun 13;66(11):1638-43
references.pmid: 16769933
references.citation: Future Neurol. 2008 May;3(3):309-323
references.pmid: 18806889
references.citation: Regul Pept. 2009 Jan 8;152(1-3):13-21
references.pmid: 18721831
references.citation: J Neural Transm (Vienna). 2008 Dec;115(12):1661-71
references.pmid: 18974920
references.citation: J Neuropathol Exp Neurol. 2008 Jun;67(6):523-31
references.pmid: 18520771
references.citation: Mol Biol Cell. 2006 Apr;17(4):1652-63
references.pmid: 16452635
references.citation: J Neurosci. 2008 Oct 22;28(43):10825-34
references.pmid: 18945890
references.citation: J Neuropathol Exp Neurol. 1999 Feb;58(2):188-97
references.pmid: 10029101
references.citation: Nat Med. 2005 Jul;11(7):725-30
references.pmid: 16015365
references.citation: Neuroscience. 2007 Apr 14;145(4):1233-48
references.pmid: 17303344
references.citation: J Neuropathol Exp Neurol. 2005 Sep;64(9):816-30
references.pmid: 16141792
references.citation: J Clin Invest. 2009 Mar;119(3):650-60
references.pmid: 19229105
references.citation: Protein Pept Lett. 2009;16(1):14-26
references.pmid: 19149668
references.citation: J Inorg Biochem. 2009 Jan;103(1):87-93
references.pmid: 18976814
references.citation: Biochim Biophys Acta. 2009 May;1787(5):335-44
references.pmid: 19268425
references.citation: Results Probl Cell Differ. 2006;42:147-81
references.pmid: 16903211
references.citation: Biochem J. 2008 Oct 15;415(2):165-82
references.pmid: 18800967
references.citation: J Clin Invest. 2009 Mar;119(3):442-5
references.pmid: 19306499
references.citation: Biochem J. 2004 Nov 1;383(Pt. 3):439-46
references.pmid: 15285718
references.citation: Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5907-12
references.pmid: 19321417
references.citation: Neuron. 2004 Jul 8;43(1):5-17
references.pmid: 15233913
references.citation: Front Biosci. 2008 May 01;13:3288-311
references.pmid: 18508433
references.citation: J Neurochem. 2006 Jun;97(6):1634-58
references.pmid: 16805774
references.citation: Methods Enzymol. 2009;453:217-49
references.pmid: 19216909
references.citation: Brain. 2009 Apr;132(Pt 4):1093-101
references.pmid: 19155272
references.citation: Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5901-6
references.pmid: 19304802
references.citation: Brain. 2005 Nov;128(Pt 11):2665-74
references.pmid: 16219675
references.citation: Neurochem Res. 2008 Mar;33(3):589-97
references.pmid: 17940895
references.citation: J Neural Transm Suppl. 2006;(70):269-72
references.pmid: 17017540
references.citation: Mov Disord. 2007 Sep 15;22(12):1715-21
references.pmid: 17557337
references.citation: Hum Mol Genet. 2009 Feb 15;18(4):737-52
references.pmid: 19039036
references.citation: Trends Neurosci. 2005 Dec;28(12):670-6
references.pmid: 16216345
references.citation: Hum Mol Genet. 2008 Mar 15;17(6):906-17
references.pmid: 18065497
references.citation: J Neurosci. 2007 Feb 21;27(8):1973-80
references.pmid: 17314293
references.citation: Acta Neuropathol. 2008 Jul;116(1):103-18
references.pmid: 18066559
references.citation: Neurodegener Dis. 2007;4(1):13-27
references.pmid: 17429215
references.citation: Biochem Biophys Res Commun. 2009 Jan 16;378(3):518-23
references.pmid: 19056353
references.citation: Nat Rev Neurosci. 2004 Nov;5(11):863-73
references.pmid: 15496864
references.citation: J Neuropathol Exp Neurol. 2003 Dec;62(12):1241-53
references.pmid: 14692700
references.citation: PLoS Biol. 2004 Nov;2(11):e327
references.pmid: 15502868
references.citation: J Biol Chem. 2005 Nov 18;280(46):38851-61
references.pmid: 16157591
references.citation: EMBO Rep. 2004 Feb;5(2):213-8
references.pmid: 14749723
references.citation: Am J Pathol. 2008 Sep;173(3):665-81
references.pmid: 18688038
references.citation: Acta Neuropathol. 2009 Jul;118(1):71-86
references.pmid: 19238406
references.citation: J Neurosci. 2007 Jan 17;27(3):627-33
references.pmid: 17234594
references.citation: J Alzheimers Dis. 2009;16(1):15-27
references.pmid: 19158417
references.citation: Neurosci Lett. 2009 May 1;454(3):187-92
references.pmid: 19429081
references.citation: Proc Natl Acad Sci U S A. 2009 Apr 28;106(17):6980-5
references.pmid: 19369197
references.citation: Trends Neurosci. 2001 Nov;24(11 Suppl):S15-20
references.pmid: 11881740
references.citation: J Neuropathol Exp Neurol. 2009 Jan;68(1):73-82
references.pmid: 19104444
references.citation: Brain. 2008 Aug;131(Pt 8):1969-78
references.pmid: 18187492
references.citation: Ann Neurol. 2008 Mar;63(3):377-87
references.pmid: 18300294
references.citation: J Cell Mol Med. 2008 Dec;12(6A):2263-80
references.pmid: 18624755
references.citation: Neuron. 2003 Feb 20;37(4):583-95
references.pmid: 12597857
references.citation: Curr Opin Pharmacol. 2008 Feb;8(1):90-5
references.pmid: 17981502
references.citation: Science. 2001 Nov 9;294(5545):1346-9
references.pmid: 11701929
references.citation: Neurodegener Dis. 2008;5(3-4):254-6
references.pmid: 18322405
references.citation: Proc Natl Acad Sci U S A. 2005 Jan 4;102(1):227-31
references.pmid: 15615853
references.citation: Cell. 2009 Apr 3;137(1):146-58
references.pmid: 19345193
references.citation: J Cell Biol. 2008 Mar 24;180(6):1177-89
references.pmid: 18362179
references.citation: Neurochem Int. 2009 May-Jun;54(5-6):314-21
references.pmid: 19154770
references.citation: Neurosignals. 2008;16(1):41-51
references.pmid: 18097159
references.citation: Brain. 2008 Dec;131(Pt 12):3299-310
references.pmid: 18953056
references.citation: Mutat Res. 2009 Mar 31;674(1-2):3-22
references.pmid: 19114126
references.citation: FASEB J. 2008 Jul;22(7):2115-33
references.pmid: 18303094
references.citation: Acta Neuropathol. 2000 Aug;100(2):111-4
references.pmid: 10963356
references.citation: Neuropathol Appl Neurobiol. 2003 Jun;29(3):211-30
references.pmid: 12787319
references.citation: Hum Mol Genet. 2004 Jan 1;13(1):117-35
references.pmid: 14645198
references.citation: Mol Cell. 2005 Feb 4;17(3):351-65
references.pmid: 15694337
references.citation: Int J Exp Pathol. 2005 Jun;86(3):147-59
references.pmid: 15910549
references.citation: Brain Res Rev. 2008 Nov;59(1):245-52
references.pmid: 18773920
references.citation: Brain Res. 1989 Jan 16;477(1-2):90-9
references.pmid: 2495152
references.citation: J Cell Sci. 2005 Oct 15;118(Pt 20):4645-54
references.pmid: 16176937
references.citation: Nature. 2009 Feb 19;457(7232):981-9
references.pmid: 19225519
references.citation: J Neurochem. 2009 Jan;108(2):465-74
references.pmid: 19012742
references.citation: J Pathol. 2004 Nov;204(4):438-49
references.pmid: 15495240
references.citation: Neurobiol Aging. 2006 Feb;27(2):262-9
references.pmid: 16399211
references.citation: Hum Genomics. 2008 Sep;3(1):71-8
references.pmid: 19129091
references.citation: BMC Biochem. 2007 Nov 22;8 Suppl 1:S2
references.pmid: 18047739
references.citation: Nature. 2006 Oct 19;443(7113):787-95
references.pmid: 17051205
references.citation: J Biol Chem. 2009 Apr 24;284(17):11048-58
references.pmid: 19141614
references.citation: Free Radic Biol Med. 2008 Sep 1;45(5):667-78
references.pmid: 18588971
references.citation: Biochem Biophys Res Commun. 2009 Apr 24;382(1):6-8
references.pmid: 19249290
references.citation: Front Biosci. 2008 Jan 01;13:718-36
references.pmid: 17981582
references.citation: Curr Mol Med. 2008 Mar;8(2):78-91
references.pmid: 18336289
references.citation: Acta Neuropathol. 2005 Jan;109(1):5-13
references.pmid: 15645263
references.citation: Neurobiol Dis. 2009 Apr;34(1):95-106
references.pmid: 19162185
references.citation: J Alzheimers Dis. 2003 Feb;5(1):15-23
references.pmid: 12590162
references.citation: Expert Rev Proteomics. 2007 Dec;4(6):769-81
references.pmid: 18067415
references.citation: Science. 2009 Apr 3;324(5923):102-5
references.pmid: 19342591
references.citation: J Neurol Sci. 2005 Jun 15;233(1-2):145-62
references.pmid: 15896810
references.citation: Hum Mol Genet. 2009 Mar 15;18(6):1058-64
references.pmid: 19124534
references.citation: Neurosci Lett. 2009 Apr 24;454(2):152-6
references.pmid: 19429074
references.citation: Brain Res. 2005 Jan 21;1031(2):222-8
references.pmid: 15649447
references.citation: Curr Biol. 2006 Jul 25;16(14):R551-60
references.pmid: 16860735
references.citation: Front Biosci. 2007 Jan 01;12:2588-600
references.pmid: 17127265
references.citation: Eur J Neurosci. 2008 Jun;27(11):2803-20
references.pmid: 18588526
references.citation: Acc Chem Res. 2006 Sep;39(9):628-34
references.pmid: 16981679
references.citation: Science. 2003 Apr 25;300(5619):636-40
references.pmid: 12714745
references.citation: Curr Opin Neurobiol. 2007 Jun;17(3):325-30
references.pmid: 17419049
references.citation: J Cell Sci. 2005 Jul 15;118(Pt 14):3091-102
references.pmid: 15985464
references.citation: Antioxid Redox Signal. 2007 Aug;9(8):1059-96
references.pmid: 17571960
references.citation: Science. 2003 Apr 18;300(5618):486-9
references.pmid: 12702875
references.citation: J Alzheimers Dis. 2008 Aug;14(4):393-9
references.pmid: 18688089
references.citation: Proc Natl Acad Sci U S A. 2009 May 5;106(18):7619-23
references.pmid: 19372378
references.citation: Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4078-83
references.pmid: 12642658
references.citation: J Biol Chem. 2004 Nov 12;279(46):47746-53
references.pmid: 15364911
references.citation: Arch Med Res. 2008 Jan;39(1):1-16
references.pmid: 18067990
references.citation: Cell Cycle. 2007 Oct 1;6(19):2360-5
references.pmid: 17700067
references.citation: Trends Neurosci. 2009 Mar;32(3):150-9
references.pmid: 19162340
references.citation: Neuropathol Appl Neurobiol. 2007 Feb;33(1):2-42
references.pmid: 17239006
references.citation: Biochim Biophys Acta. 2008 Jul;1783(7):1381-95
references.pmid: 18298958
references.citation: Free Radic Biol Med. 2002 Jun 1;32(11):1076-83
references.pmid: 12031892
references.citation: Exp Neurol. 2006 Jun;199(2):249-56
references.pmid: 16310772
references.citation: J Alzheimers Dis. 2004 Apr;6(2):171-5
references.pmid: 15096701
references.citation: Curr Top Dev Biol. 2006;75:25-71
references.pmid: 16984809
references.citation: Ageing Res Rev. 2003 Oct;2(4):343-56
references.pmid: 14522239
references.citation: Brain Behav Immun. 2009 May;23(4):507-17
references.pmid: 19486646
references.citation: Eur J Neurosci. 2007 Dec;26(11):3104-12
references.pmid: 18005066
references.citation: Curr Alzheimer Res. 2008 Oct;5(5):457-68
references.pmid: 18855587
references.citation: Free Radic Biol Med. 2005 Mar 1;38(5):665-77
references.pmid: 15683722
references.citation: Biosci Rep. 2007 Jun;27(1-3):87-104
references.pmid: 17486441
references.citation: Eur J Neurosci. 1999 Oct;11(10):3369-76
references.pmid: 10564344
references.citation: Brain. 2008 Sep;131(Pt 9):2414-24
references.pmid: 18678563
references.citation: Acta Neuropathol. 2008 Jul;116(1):47-55
references.pmid: 18343932
references.citation: Science. 2004 Apr 16;304(5669):448-52
references.pmid: 15087549
references.citation: J Cell Biochem. 2006 Sep 1;99(1):52-70
references.pmid: 16823798
references.citation: Annu Rev Pharmacol Toxicol. 2009;49:73-96
references.pmid: 18834306
references.citation: Cell. 2009 Apr 3;137(1):133-45
references.pmid: 19345192
references.citation: Curr Top Dev Biol. 2007;78:217-45
references.pmid: 17338918
references.citation: Pharmacol Ther. 2009 Feb;121(2):147-59
references.pmid: 19000712
references.citation: Methods Mol Biol. 2008;445:195-211
references.pmid: 18425452
references.citation: Ann Neurol. 2005 May;57(5):695-703
references.pmid: 15852400
references.citation: Biochem Biophys Res Commun. 2009 May 1;382(2):321-5
references.pmid: 19285961
references.citation: Mol Neurodegener. 2008 Dec 29;3:21
references.pmid: 19114014
references.citation: Exp Mol Med. 2006 Aug 31;38(4):333-47
references.pmid: 16953112
references.citation: Neurochem Res. 2009 Apr;34(4):727-33
references.pmid: 19199029
references.citation: J Neurosci. 2008 Jul 23;28(30):7687-98
references.pmid: 18650345
references.citation: Curr Alzheimer Res. 2006 Sep;3(4):377-91
references.pmid: 17017868
references.citation: J Alzheimers Dis. 2009;16(3):551-64
references.pmid: 19276550
references.citation: J Biomed Biotechnol. 2006;2006(3):62079
references.pmid: 17047309
references.citation: Cell Mol Life Sci. 2005 Jul;62(14):1532-46
references.pmid: 15905967
references.citation: Mol Cell Proteomics. 2005 Oct;4(10):1471-9
references.pmid: 15975914
references.citation: Nature. 2009 Feb 26;457(7233):1128-32
references.pmid: 19242475
references.citation: J Neurosci Res. 2008 Jul;86(9):2071-82
references.pmid: 18335520
references.citation: Prog Neurobiol. 2007 Apr;81(5-6):272-93
references.pmid: 17188796
references.citation: IUBMB Life. 2008 Sep;60(9):575-90
references.pmid: 18478527
references.citation: Ann N Y Acad Sci. 2004 Dec;1035:250-70
references.pmid: 15681812
references.citation: Trends Immunol. 2008 Aug;29(8):357-65
references.pmid: 18599350
references.citation: Ann Neurol. 2008 Dec;64 Suppl 2:S101-10
references.pmid: 19127580
references.citation: Proc Natl Acad Sci U S A. 2009 May 5;106(18):7443-8
references.pmid: 19376973
references.citation: Curr Alzheimer Res. 2006 Sep;3(4):359-64
references.pmid: 17017866
references.citation: Aging Clin Exp Res. 2005 Feb;17(1):1-7
references.pmid: 15847115
references.citation: Curr Protein Pept Sci. 2008 Oct;9(5):507-40
references.pmid: 18855701
references.citation: Exp Neurol. 2004 Jun;187(2):235-9
references.pmid: 15144849
references.citation: J Intern Med. 2005 Dec;258(6):479-517
references.pmid: 16313474
references.citation: Trends Biochem Sci. 2007 Jan;32(1):37-43
references.pmid: 17141506
references.citation: J Alzheimers Dis. 2007 Jul;11(4):457-63
references.pmid: 17656824
references.citation: Am J Pathol. 2008 Jun;172(6):1683-92
references.pmid: 18467692
references.citation: Mov Disord. 2001 Mar;16(2):185-9
references.pmid: 11295768
references.citation: EMBO J. 2008 Jan 23;27(2):336-49
references.pmid: 18216876
references.citation: Neurochem Res. 2009 Jan;34(1):55-65
references.pmid: 18363100
references.citation: J Neuropathol Exp Neurol. 2006 Apr;65(4):327-35
references.pmid: 16691114
references.citation: Biophys J. 2005 Dec;89(6):4201-10
references.pmid: 16169975
references.citation: Ann Neurol. 2003;53 Suppl 3:S61-70; discussion S70-2
references.pmid: 12666099
references.citation: Neurobiol Aging. 2008 Nov;29(11):1607-18
references.pmid: 17544172
references.citation: Neurotox Res. 2002 May;4(3):191-209
references.pmid: 12829400
references.citation: J Biol Chem. 2003 Jun 13;278(24):21323-6
references.pmid: 12719435
references.citation: Neurosci Lett. 2006 Dec 1;409(2):95-9
references.pmid: 17010516
references.citation: Cell Death Differ. 2006 Mar;13(3):385-92
references.pmid: 16397584
references.citation: J Alzheimers Dis. 2008 Aug;14(4):449-52
references.pmid: 18688097
references.citation: Curr Alzheimer Res. 2009 Feb;6(1):36-47
references.pmid: 19199873
references.citation: Mol Vis. 2008;14:2443-50
references.pmid: 19104679
references.citation: Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10417-22
references.pmid: 12925731
references.citation: IUBMB Life. 2008 Nov;60(11):724-8
references.pmid: 18756529
references.citation: Genes Dev. 2008 Jun 1;22(11):1427-38
references.pmid: 18519635
references.citation: J Neurosci. 2009 Mar 18;29(11):3565-78
references.pmid: 19295161
references.citation: J Neurochem. 2004 Jan;88(2):401-10
references.pmid: 14690528
references.citation: Annu Rev Neurosci. 2005;28:57-87
references.pmid: 16022590
references.citation: Nat Cell Biol. 2004 Nov;6(11):1054-61
references.pmid: 15516999
references.citation: J Bioenerg Biomembr. 2004 Aug;36(4):375-9
references.pmid: 15377875
references.citation: Science. 2007 Jan 12;315(5809):201-5
references.pmid: 17218518
references.citation: J Neuropathol Exp Neurol. 2001 Sep;60(9):829-38
references.pmid: 11556539
references.citation: J Alzheimers Dis. 2006 Jul;9(2):119-26
references.pmid: 16873959
references.citation: Curr Opin Struct Biol. 2009 Feb;19(1):14-22
references.pmid: 19157856
references.citation: J Cell Biol. 2003 May 12;161(3):489-95
references.pmid: 12743103
references.citation: Acta Neuropathol. 2008 Aug;116(2):205-13
references.pmid: 18607609
references.citation: Trends Neurosci. 2008 Oct;31(10):521-8
references.pmid: 18778858
references.citation: Ann Neurol. 2008 Dec;64 Suppl 2:S3-15
references.pmid: 19127586
references.citation: Neurobiol Aging. 2005 Aug-Sep;26(8):1183-92
references.pmid: 15917102
references.citation: Exp Neurol. 2003 Oct;183(2):263-8
references.pmid: 14552867
references.citation: Acta Neuropathol. 2009 Mar;117(3):227-46
references.pmid: 19142648
references.citation: Neuroscience. 2009 Feb 6;158(3):1143-50
references.pmid: 18805461
references.citation: Neuroscience. 2008 Aug 26;155(3):725-37
references.pmid: 18621106
references.citation: EMBO J. 2009 Feb 18;28(4):372-82
references.pmid: 19153604
references.citation: J Neurosci. 2005 Jun 8;25(23):5544-52
references.pmid: 15944382
references.citation: Exp Neurol. 2004 Jun;187(2):279-88
references.pmid: 15144854
references.citation: Nat Rev Neurosci. 2003 May;4(5):365-75
references.pmid: 12728264
references.citation: J Neural Transm Suppl. 2006;(70):111-7
references.pmid: 17017517
references.citation: Exp Cell Res. 2008 Jun 10;314(10):2055-65
references.pmid: 18445495
references.citation: J Neurochem. 2008 Oct;107(2):317-28
references.pmid: 18680555
references.citation: J Neurosci. 2008 Mar 26;28(13):3521-30
references.pmid: 18367618
references.citation: J Biol Chem. 2009 Mar 27;284(13):8495-506
references.pmid: 19164281
references.citation: Neuron. 2008 Nov 26;60(4):534-42
references.pmid: 19038212
references.citation: Acta Neuropathol. 2009 Aug;118(2):303-11
references.pmid: 19283396
references.citation: Acta Neuropathol. 1995;89(1):35-41
references.pmid: 7709729
references.citation: Arch Neurol. 2008 Feb;65(2):184-9
references.pmid: 18268186
references.citation: J Biol Chem. 2004 Jun 11;279(24):25497-502
references.pmid: 15044495
references.citation: Cell. 2008 Jan 11;132(1):101-12
references.pmid: 18191224
references.citation: J Biol Chem. 2006 Jan 13;281(2):1205-14
references.pmid: 16246844
references.citation: J Alzheimers Dis. 2008 Mar;13(2):151-60
references.pmid: 18376057
references.citation: Nat Genet. 2009 Feb;41(2):163-5
references.pmid: 19136952
references.citation: Hum Genet. 2006 Apr;119(3):241-54
references.pmid: 16408223
references.citation: Trends Neurosci. 2006 Sep;29(9):528-35
references.pmid: 16859759
references.citation: Brain Res. 2002 Mar 15;930(1-2):170-81
references.pmid: 11879807
references.citation: Acta Neuropathol. 2009 Feb;117(2):125-36
references.pmid: 19139911
references.citation: Ann N Y Acad Sci. 2009 Feb;1153:240-6
references.pmid: 19236346
references.citation: Apoptosis. 2009 Apr;14(4):478-500
references.pmid: 19165601
references.citation: Mol Immunol. 2007 Feb;44(5):999-1010
references.pmid: 16698083
references.citation: Eur J Cell Biol. 2009 Apr;88(4):193-202
references.pmid: 19147253
references.citation: J Biol Chem. 2007 Feb 23;282(8):5862-70
references.pmid: 17189262
references.citation: Ann N Y Acad Sci. 2004 Mar;1012:224-36
references.pmid: 15105269
references.citation: Acta Neuropathol. 2009 Sep;118(3):381-9
references.pmid: 19277685
references.citation: Brain. 2009 Feb;132(Pt 2):288-95
references.pmid: 18567623
references.citation: J Neural Transm (Vienna). 2008 Sep;115(9):1285-99
references.pmid: 18528629
references.citation: J Clin Invest. 2005 Oct;115(10):2679-88
references.pmid: 16200202
references.citation: Biochim Biophys Acta. 2008 Oct;1783(10):1815-25
references.pmid: 18619498
references.citation: Curr Mol Med. 2008 May;8(3):207-20
references.pmid: 18473820
references.citation: J Neuropathol Exp Neurol. 2001 Aug;60(8):759-67
references.pmid: 11487050
references.citation: J Neurochem. 2009 May;109 Suppl 1:198-206
references.pmid: 19393028
references.citation: Curr Alzheimer Res. 2005 Jan;2(1):19-28
references.pmid: 15977986
references.citation: FEBS Lett. 2003 Jan 30;535(1-3):77-81
references.pmid: 12560082
references.citation: Int J Biochem Cell Biol. 2008;40(2):181-98
references.pmid: 17804276
references.citation: Neuropathol Appl Neurobiol. 2008 Apr;34(2):169-80
references.pmid: 17961133
references.citation: DNA Repair (Amst). 2009 Apr 5;8(4):444-8
references.pmid: 19272841
references.citation: J Neurosci. 2006 Oct 25;26(43):11111-9
references.pmid: 17065451
references.citation: FASEB J. 2005 Apr;19(6):533-42
references.pmid: 15791003
references.citation: J Neurosci. 2008 Aug 13;28(33):8189-98
references.pmid: 18701681
references.citation: Brain Pathol. 2008 Apr;18(2):267-78
references.pmid: 18363937
references.citation: Annu Rev Neurosci. 2008;31:151-73
references.pmid: 18558852
references.citation: J Biol Chem. 2002 Dec 27;277(52):50966-72
references.pmid: 12393885
references.citation: Int J Mol Sci. 2008 Dec;9(12):2515-42
references.pmid: 19330090
references.citation: Prog Neurobiol. 2007 Apr;81(5-6):294-330
references.pmid: 17379385
references.citation: Ann Neurol. 2009 Jan;65(1):24-31
references.pmid: 19194878
references.citation: Biochim Biophys Acta. 2006 Nov-Dec;1762(11-12):1051-67
references.pmid: 16713195
references.citation: J Mol Neurosci. 2009 May;38(1):19-30
references.pmid: 18953672
references.citation: Brain Pathol. 2009 Apr;19(2):177-87
references.pmid: 18462470
references.citation: J Biol Chem. 2009 Apr 10;284(15):9796-803
references.pmid: 19218238
references.citation: Biochem Soc Trans. 2005 Nov;33(Pt 5):1082-6
references.pmid: 16246050
references.citation: J Biol Chem. 2009 Jul 10;284(28):18754-66
references.pmid: 19389700
references.citation: J Alzheimers Dis. 2009;16(4):879-95
references.pmid: 19387120
references.citation: Anal Biochem. 2009 Mar 15;386(2):293-5
references.pmid: 19135970
references.citation: Hum Mol Genet. 2007 Feb 15;16(4):391-409
references.pmid: 17189290
references.citation: J Neurosci. 2008 Dec 3;28(49):13285-95
references.pmid: 19052220
references.citation: Lancet. 2008 Jul 19;372(9634):216-23
references.pmid: 18640458
references.citation: Nature. 2006 Oct 19;443(7113):768-73
references.pmid: 17051202
references.citation: J Neurochem. 2007 Oct;103(1):17-37
references.pmid: 17623039
references.citation: Nat Rev Mol Cell Biol. 2008 May;9(5):378-90
references.pmid: 18414491
references.citation: Cell Mol Neurobiol. 2007 Nov;27(7):867-75
references.pmid: 17952586
references.citation: Subcell Biochem. 2007;42:249-79
references.pmid: 17612055
references.citation: Biochem Pharmacol. 2003 Oct 15;66(8):1619-25
references.pmid: 14555242
references.citation: Curr Alzheimer Res. 2006 Sep;3(4):297-309
references.pmid: 17017861
references.citation: J Biol Chem. 2003 Jan 3;278(1):311-8
references.pmid: 12401807
references.citation: Psychoneuroendocrinology. 2009 May;34(4):615-9
references.pmid: 19028017
references.citation: Acta Neuropathol. 2008 Jul;116(1):17-24
references.pmid: 18446351
references.citation: Free Radic Biol Med. 2008 Aug 1;45(3):219-30
references.pmid: 18482592
references.citation: Nat Rev Neurosci. 2005 Jan;6(1):11-22
references.pmid: 15611723
references.citation: J Neurosci. 2009 Apr 15;29(15):4964-71
references.pmid: 19369565
references.citation: Biochim Biophys Acta. 2008 Dec;1782(12):681-2
references.pmid: 18845251
references.citation: J Neurochem. 2008 Oct;107(1):265-78
references.pmid: 18691386
references.citation: Neurobiol Dis. 2009 Apr;34(1):163-77
references.pmid: 19320056
references.citation: CNS Neurol Disord Drug Targets. 2009 Mar;8(1):16-30
references.pmid: 19275634
references.citation: J Neural Transm (Vienna). 2008;115(1):59-66
references.pmid: 17705040
references.citation: J Neurosci. 2001 Jun 15;21(12):4183-7
references.pmid: 11404403
references.citation: Hum Mol Genet. 2004 Jul 1;13(13):1389-405
references.pmid: 15115766
references.citation: J Pathol. 2006 Feb;208(3):319-26
references.pmid: 16261658
references.citation: Front Biosci. 2007 Jan 01;12:733-56
references.pmid: 17127334
references.citation: J Cell Sci. 2005 Dec 1;118(Pt 23):5411-9
references.pmid: 16306220
references.citation: J Biol Chem. 2008 Feb 29;283(9):5780-9
references.pmid: 18156184
references.citation: Neurology. 2002 Feb 26;58(4):589-92
references.pmid: 11865137
references.citation: J Neuropathol Exp Neurol. 2005 Feb;64(2):104-12
references.pmid: 15751224
references.citation: Curr Med Chem. 2009;16(8):931-9
references.pmid: 19275603
references.citation: Glia. 2007 Oct;55(13):1348-61
references.pmid: 17654703
references.citation: Mol Neurodegener. 2009 May 06;4:20
references.pmid: 19419557
references.citation: Brain Pathol. 2008 Apr;18(2):225-38
references.pmid: 18093249
references.citation: J Neurosci. 2008 Dec 31;28(53):14537-45
references.pmid: 19118188
references.citation: J Alzheimers Dis. 2008 May;14(1):27-41
references.pmid: 18525125
references.citation: Ann N Y Acad Sci. 2008 Dec;1147:21-9
references.pmid: 19076427
references.citation: Acta Neuropathol. 2009 Feb;117(2):137-49
references.pmid: 19125255
references.citation: Neuroscience. 2007 Apr 14;145(4):1318-29
references.pmid: 17092652