title: Obesity and acute lung injury.
abstract: Acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS) are common indications for ICU admission and mechanical ventilation. ALI/ARDS also consumes significant health care resources and is a common cause of death in ICU patients. Obesity produces changes in respiratory system physiology that could affect outcomes for ALI/ARDS patients and their response to treatment. Additionally, the biochemical alterations seen in obese patients, such as increased inflammation and altered metabolism, could affect the risk of developing ALI/ARDS in patients with another risk factor (eg, sepsis). The few studies that have examined the influence of obesity on the outcomes from ALI/ARDS are inconclusive. Furthermore, observed results could be biased by disparities in provided care.
authors.affiliation: Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Center for Critical Care, The Ohio State University Medical Center, Columbus, OH 43210, USA.
authors.forename: Jennifer W
authors.initials: JW
authors.lastname: McCallister
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Adkins
authors.forename: James M
authors.initials: JM
authors.lastname: O'Brien
mesh_terms: D055371:Acute Lung Injury / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D009102:Multiple Organ Failure / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D009765:Obesity / Q000150:complications* / Q000503:physiopathology* / Q000628:therapy; D012128:Respiratory Distress Syndrome / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D015656:Respiratory Mechanics / Q000502:physiology
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