title: Bioinorganic magnetic core-shell nanocomposites carrying antiarthritic agents: intercalation of ibuprofen and glucuronic acid into Mg-Al-layered double hydroxides supported on magnesium ferrite.
abstract: This paper describes the synthesis and characterization of a composite constituted by an antiarthritic agent (AA) intercalated into a layered double hydroxide (LDH) supported on magnesium ferrite. Core-shell nanocomposites were prepared by depositing Mg-Al-NO(3)-LDH on a MgFe(2)O(4) core prepared by calcination of a nonstoichiometric Mg-Fe-CO(3)-LDH. Intercalation of ibuprofen and glucuronate anions was performed by ion-exchange with nitrate ions. The structural characteristics of the obtained products were investigated by powder X-ray diffraction, element chemical analysis, Fourier transform infrared spectroscopy, and thermogravimetric analysis. Morphologies of the nanocomposite particles were examined by scanning electron microscopy and transmission electron microscopy. The products were shown to intercalate substantial amounts of AA with enhanced thermal stabilities. Room-temperature magnetic measurements by vibrating sample magnetometry revealed that the products show soft ferromagnetic properties suitable for potential utilization in magnetic arthritis therapy.
authors.affiliation: Hacettepe University, Chemistry Department, Beytepe Campus, 06800 Ankara, Turkey.
authors.forename: Ahmet Nedim
authors.initials: AN
authors.lastname: Ay
authors.forename: Birgül
authors.initials: B
authors.lastname: Zümreoglu-Karan
authors.forename: Abidin
authors.initials: A
authors.lastname: Temel
authors.forename: Vicente
authors.initials: V
authors.lastname: Rives
mesh_terms: D000536:Aluminum Hydroxide / Q000737:chemistry*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry; D005290:Ferric Compounds / Q000737:chemistry*; D020723:Glucuronic Acid / Q000737:chemistry*; D007052:Ibuprofen / Q000737:chemistry*; D008274:Magnesium / Q000737:chemistry*; D017616:Magnesium Compounds / Q000737:chemistry*; D008280:Magnetics; D008855:Microscopy, Electron, Scanning; D008954:Models, Biological; D015394:Molecular Structure; D049329:Nanostructures
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004337:Drug Carriers; D005290:Ferric Compounds; D017616:Magnesium Compounds; C016546:magnesium ferrite; D000536:Aluminum Hydroxide; D020723:Glucuronic Acid; D008274:Magnesium; D007052:Ibuprofen