title: Isolated skull base metastasis as the first manifestation of hepatocellular carcinoma--a rare case report with review of literature.
abstract: BACKGROUND
  Hepatocellular carcinoma rarely metastasizes to skull base.
  
  
  METHODS
  We report an extremely rare case of solitary skull base metastasis without metastasis to any other site, with right third, fourth, and sixth cranial nerve palsy as the initial manifestation of the disease.
  
  
  CONCLUSIONS
  The biopsy specimen of skull base lytic lesion suggested metastatic hepatocellular carcinoma. Subsequent examination revealed a large mass involving superior segment of right lobe of liver, which was confirmed as hepatocellular carcinoma on histopathological examination.
  
  
  CONCLUSIONS
  Until now, there have been only 24 cases of hepatocellular carcinoma metastasizing to skull base cited in literature. We report here an unusual case of solitary skull base metastasis from hepatocellular carcinoma prior to the diagnosis of primary tumor.
authors.affiliation: Department of Pathology, The Gujarat Cancer & Research Institute, Ahmedabad, Gujarat, India. priti_patho@yahoo.co.in
authors.forename: Priti
authors.initials: P
authors.lastname: Trivedi
authors.forename: Anuja
authors.initials: A
authors.lastname: Gupta
authors.forename: Sunil
authors.initials: S
authors.lastname: Pasricha
authors.forename: Gaurav
authors.initials: G
authors.lastname: Agrawal
authors.forename: Manoj
authors.initials: M
authors.lastname: Shah
mesh_terms: D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000556:secondary*; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D019292:Skull Base Neoplasms / Q000473:pathology*
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