Involvement of interleukin-21 in the epidermal hyperplasia of psoriasis.
T cells are crucial mediators of the skin damage in psoriasis. We here show that interleukin-21 (IL-21), a T cell-derived cytokine, is highly expressed in the skin of individuals with psoriasis, stimulates human keratinocytes to proliferate and causes epidermal hyperplasia when injected intradermally into mice. In the human psoriasis xenograft mouse model, blockade of IL-21 activity resolves inflammation and reduces keratinocyte proliferation. Blocking IL-21 may represent a new therapeutic strategy in psoriasis.
Caruso
Roberta
R
Gastroenterology, University Tor Vergata of Rome, Rome, Italy.
Botti
Elisabetta
E
Sarra
Massimiliano
M
Esposito
Maria
M
Stolfi
Carmine
C
Diluvio
Laura
L
Giustizieri
Maria Laura
ML
Pacciani
Valentina
V
Mazzotta
Annamaria
A
Campione
Elena
E
Macdonald
Thomas T
TT
Chimenti
Sergio
S
Pallone
Francesco
F
Costanzo
Antonio
A
Monteleone
Giovanni
G
D000818:Animals; D016022:Case-Control Studies; D049109:Cell Proliferation / Q000187:drug effects; D004195:Disease Models, Animal; D006801:Humans; D006965:Hyperplasia; D007378:Interleukins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000494:pharmacology / Q000502:physiology*; D015603:Keratinocytes / Q000187:drug effects / Q000276:immunology / Q000473:pathology / Q000637:transplantation; D051379:Mice; D011565:Psoriasis / Q000235:genetics / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D011994:Recombinant Proteins / Q000494:pharmacology; D013601:T-Lymphocytes / Q000276:immunology; D014183:Transplantation, Heterologous; D000098546:Interleukin-21
D007378:Interleukins; D012333:RNA, Messenger; D011994:Recombinant Proteins; D000098546:Interleukin-21
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