Synthesis and biological evaluation of asymmetric gramicidin S analogues containing modified D-phenylalanine residues.
The synthesis of new analogues of the cationic antimicrobial peptide gramicidin S, having a modified D-phenylalanine residue, their antibacterial properties against several gram positive and negative strains, as well as their hemolytic activity is reported.
van der Knaap
Matthijs
M
Bio-Organic Synthesis, Leiden Institute of Chemistry, University of Leiden, Leiden, The Netherlands.
Engels
Eefje
E
Busscher
Henk J
HJ
Otero
José M
JM
Llamas-Saiz
Antonio L
AL
van Raaij
Mark J
MJ
Mars-Groenendijk
Roos H
RH
Noort
Daan
D
van der Marel
Gijsbert A
GA
Overkleeft
Herman S
HS
Overhand
Mark
M
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004912:Erythrocytes / Q000187:drug effects; D006096:Gramicidin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D006461:Hemolysis; D006801:Humans; D008826:Microbial Sensitivity Tests; D010649:Phenylalanine / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D006096:Gramicidin; D010649:Phenylalanine