title: Epidemiological networks and drug resistance of HIV type 1 in Krasnoyarsk region, Russia.
abstract: To study the molecular epidemiology of HIV-1 in Krasnoyarsk region, Russia, where HIV-1 has spread rapidly since 2000, we obtained pol sequences from individuals living in this region (n = 67) as well as in the geographically closely related Altay region (n = 13). In both regions, subtype A viruses specific for the former Soviet Union (IDU-A strains) were dominant (92.5%). Virus sequences clustered according to the geographic origin of the infected individuals rather than to their risk group, demonstrating the role of geographically defined epidemiological networks in the propagation of the HIV-1 epidemic in the region. Six viruses belonged to subtype B. Three of them were phylogenetically (and therefore epidemiologically) closely related to each other, demonstrating that even though IDU-A viruses dominate the epidemic, the spread of other virus strains does occur. Most viruses (75%) had an A62V mutation in reverse transcriptase, specific for HIV-1 strains in Russia. Remarkably, 26 of 47 (55%) patients under HAART with detectable virus loads did not have any known drug-resistant mutation, indicating the need to increase compliance to therapy.
authors.affiliation: Krasnoyarsk Regional AIDS Center, Krasnoyarsk, Russia.
authors.forename: Olga A
authors.initials: OA
authors.lastname: Rumyantseva
authors.forename: Igor A
authors.initials: IA
authors.lastname: Olkhovskiy
authors.forename: Marina A
authors.initials: MA
authors.lastname: Malysheva
authors.forename: Ludmila A
authors.initials: LA
authors.lastname: Ruzaeva
authors.forename: Alexander V
authors.initials: AV
authors.lastname: Vasiliev
authors.forename: Elena V
authors.initials: EV
authors.lastname: Kazennova
authors.forename: Marina R
authors.initials: MR
authors.lastname: Bobkova
authors.forename: Vladimir V
authors.initials: VV
authors.lastname: Lukashov
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000494:pharmacology*; D002648:Child; D002675:Child, Preschool; D016000:Cluster Analysis; D024882:Drug Resistance, Viral; D005260:Female; D005838:Genotype; D005843:Geography; D015658:HIV Infections / Q000453:epidemiology* / Q000821:virology*; D015497:HIV-1 / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D020125:Mutation, Missense; D010802:Phylogeny; D012426:Russia / Q000453:epidemiology; D017422:Sequence Analysis, DNA; D017385:Sequence Homology; D055815:Young Adult
chemical_list: D019380:Anti-HIV Agents