title: Three-dimensional profile of macular retinal thickness in normal Japanese eyes.
abstract: OBJECTIVE
  To demonstrate the three-dimensional macular thickness distribution in normal subjects by spectral domain optical coherence tomography (SD-OCT) and evaluate its association with sex, age, and axial length.
  
  
  METHODS
  Mean regional retinal thickness measurements on the Early Treatment Diabetic Retinopathy Study (ETDRS) layout were obtained by three-dimensional raster scanning (6 x 6 mm) using SD-OCT in 248 normal eyes of 248 Japanese subjects.
  
  
  RESULTS
  Mean foveal thickness was 222 +/- 19 microm; it was significantly greater in men (226 +/- 19 microm) than in women (218 +/- 18 microm; P = 0.002) and did not correlate with age in either sex. Mean sectoral retinal thickness was also significantly greater in the men than in the women in all the quadrants of the inner ring (1-3 mm; P < 0.001 and P = 0.001-0.007) and in the temporal quadrant of the outer ring (3-6 mm; P < 0.001). The retinal thicknesses of each of the ETDRS sectors did not correlate significantly with axial length after adjustment for age in either sex. Retinal thickness in six of the eight sectors in the inner and outer rings showed a negative correlation with age after adjustment for axial length in the men (P < 0.001 and P = 0.001-0.018), whereas no correlation with age was observed in the women.
  
  
  CONCLUSIONS
  SD-OCT demonstrated the three-dimensional macular thickness distribution in normal eyes. Macular thickness varied significantly with sex and age. These variables should be considered while evaluating macular thickness.
authors.affiliation: Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.
authors.forename: Sotaro
authors.initials: S
authors.lastname: Ooto
authors.forename: Masanori
authors.initials: M
authors.lastname: Hangai
authors.forename: Atsushi
authors.initials: A
authors.lastname: Sakamoto
authors.forename: Atsuo
authors.initials: A
authors.lastname: Tomidokoro
authors.forename: Makoto
authors.initials: M
authors.lastname: Araie
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Otani
authors.forename: Shoji
authors.initials: S
authors.lastname: Kishi
authors.forename: Kenji
authors.initials: K
authors.lastname: Matsushita
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Maeda
authors.forename: Motohiro
authors.initials: M
authors.lastname: Shirakashi
authors.forename: Haruki
authors.initials: H
authors.lastname: Abe
authors.forename: Hisashi
authors.initials: H
authors.lastname: Takeda
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Sugiyama
authors.forename: Hitomi
authors.initials: H
authors.lastname: Saito
authors.forename: Aiko
authors.initials: A
authors.lastname: Iwase
authors.forename: Nagahisa
authors.initials: N
authors.lastname: Yoshimura
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D044466:Asian People; D001837:Body Weights and Measures; D005123:Eye / Q000033:anatomy & histology; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D007564:Japan; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012160:Retina / Q000033:anatomy & histology*; D017678:Sex Distribution; D041623:Tomography, Optical Coherence / Q000379:methods*; D055815:Young Adult