title: Fibronectin as an adjuvant in the diagnosis of oral inflammatory myofibroblastic tumor.
abstract: Inflammatory myofibroblastic tumor is a distinctive lesion composed of myofibroblastic spindle shaped cells accompanied by inflammatory infiltrate that may arise in various organs. It is believed to be a noneoplastic inflammatory condition, although this is still controversial. The recognition of inflammatory myofibroblastic tumor as an entity is important especially to avoid unnecessary surgery. A few cases have been reported in the oral cavity. This report primarily presents a case of inflammatory myofibroblastic tumor that arose in the floor of mouth of a 23-year-old woman. The proliferating spindle cells were immunoreactive for vimentin, smooth muscle actin, and muscle specific actin and negative for desmin, AE1/AE3, S-100, CD68, MyoD1 and caldesmon. In an attempt to assess the potential neoplastic nature of this lesion, immunohistochemical expression of ALK protein was performed, although no immunoreactivity was detected. Also, the presence of well differentiated myofibroblasts identified by fibronectin is discussed, as well as the importance in establishing an immunoprofile to better consolidate the diagnosis. We conclude that the study of fibronectin in case series may aid the diagnosis as well as the prediction of the tumor course.
authors.affiliation: Department of Oral Pathology, School of Dentistry, University of São Paulo, 2227 São Paulo - SP, Brasil - 05508-900. f.calo@usp.br
authors.forename: Flávia-Caló-Aquino
authors.initials: FC
authors.lastname: Xavier
authors.forename: André-Caroli
authors.initials: AC
authors.lastname: Rocha
authors.forename: Norberto-Nobuo
authors.initials: NN
authors.lastname: Sugaya
authors.forename: Décio
authors.initials: D
authors.lastname: dos Santos-Pinto
authors.forename: Suzana-Cantanhede-Orsini-Machado
authors.initials: SC
authors.lastname: de Sousa
mesh_terms: D005260:Female; D005353:Fibronectins / Q000032:analysis*; D006801:Humans; D009062:Mouth Neoplasms / Q000737:chemistry* / Q000473:pathology*; D055815:Young Adult
chemical_list: D005353:Fibronectins