Neuroprotective and neurotrophic effects of isorosmanol.
The neurotoxicity induced by beta-amyloid (Abeta), which is one of the major causes of Alzheimer's disease (AD), leads to synaptic loss and subsequent neuronal death. Therefore, modulation of Abeta-induced neurotoxicity, as well as regeneration of damaged synapses could be important therapeutic approaches to control AD. In this study, we found that isorosmanol, an abietane-type diterpene, protected PC12 cells against Abeta-induced toxicity. Furthermore, isorosmanol promoted the generation of neurites. The neurotrophic effect of isorosmanol was enhanced by co-treatment with nerve growth factor (NGF). In addition, the neurite outgrowth induced by isorosmanol was accompanied by F-actin redistribution and increased expression of neurofilaments. Taken together, these results suggest that isorosmanol possesses both neuroprotective and neurotrophic effects, that might be beneficial for controlling AD.
Park
So-Young
SY
Environmental Toxico-Genomic & Proteomic Center, College of Medicine, Korea University, 126-1 Anam-Dong, 5Ga, Sungbuk-Gu, Seoul 136-701, Korea. soypark23@gmil.com
D045784:Abietanes; D000199:Actins / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D004224:Diterpenes / Q000494:pharmacology*; D009414:Nerve Growth Factors / Q000494:pharmacology; D016501:Neurites / Q000187:drug effects / Q000502:physiology*; D016716:PC12 Cells / Q000187:drug effects / Q000473:pathology*; D051381:Rats
D045784:Abietanes; D000199:Actins; D004224:Diterpenes; D009414:Nerve Growth Factors; C465581:rosmanol