Development of resistance of an organism under various conditions of hypoxic preconditioning: role of the hypoxic period and reoxygenation.
Single exposure to moderate (10% O(2)) hypobaric, normobaric, and intermittent hypoxia is followed by a preconditioning response of the organism. The mechanisms for immediate adaptation are activated during the hypoxic period. Intermittent reoxygenation not only delays, but even suppresses this process. However, periods of oxygenation during the course of hypoxic training reduce the effect of hypoxia and prevent the possibility for "overdosage" of the adverse stimulus. Hence, they have a regulatory or normalizing role under these conditions. Our results indicate that hypoxitherapy in intermittent hypoxia mode provides optimum conditions for long-term adaptation.
Lukyanova
L D
LD
Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow. Russia. ldluk@mail.ru
Germanova
E L
EL
Kopaladze
R A
RA
D000818:Animals; D006339:Heart Rate / Q000502:physiology; D000860:Hypoxia / Q000503:physiopathology* / Q000517:prevention & control*; D008297:Male; D010100:Oxygen / Q000378:metabolism*; D011897:Random Allocation; D051381:Rats; D013997:Time Factors
D010100:Oxygen