Sucrose synthase: expanding protein function.
SUCROSE SYNTHASE (SUS: EC 2.4.1.13), a key enzyme in plant sucrose catabolism, is uniquely able to mobilize sucrose into multiple pathways involved in metabolic, structural, and storage functions. Our research indicates that the biological function of SUS may extend beyond its catalytic activity. This inference is based on the following observations: (a) tissue-specific, isoform-dependent and metabolically-regulated association of SUS with mitochondria and (b) isoform-specific and anoxia-responsive interaction of SUS with the voltage-dependent anion channel (VDAC), the major outer mitochondrial membrane protein. More recent work shows that both VDAC and SUS are also localized to the nucleus in maize seedling tissues. Their intricate regulation under anoxia indicates that these two proteins may have a role in inter-compartmental signaling.
Subbaiah
Chalivendra C
CC
School of Life Sciences; Arizona State University; Tempe, Arizona USA.
Huber
Steven C
SC
Sachs
Martin M
MM
Rhoads
David
D
Trends Plant Sci. 2003 Feb;8(2):63-9
12597872
Plant Physiol. 2001 Oct;127(2):655-64
11598239
FEBS Lett. 1997 Dec 29;420(2-3):151-5
9459300
Mol Gen Genet. 1998 Jul;259(1):88-96
9738884
Plant Physiol. 2001 Feb;125(2):585-94
11161016
Mol Biol Evol. 2004 Apr;21(4):652-8
14739247
Plant Physiol. 1985 Oct;79(2):530-6
16664445
Plant Physiol. 2002 Apr;128(4):1490-500
11950997
Bioessays. 1997 Sep;19(9):827-32
9297974
J Biol Chem. 2006 Jun 9;281(23):15625-35
16606624
Plant Cell Physiol. 2006 Jul;47(7):959-71
16760218
Plant Physiol. 1998 Apr;116(4):1573-83
9536076