Weight loss and body fat reduction under sibutramine therapy in obesity with the C825T polymorphism in the GNB3 gene.
The relationship between weight reduction after sibutramine treatment and a single nucleotide polymorphism, rs5443 (C825T), in the guanine nucleotide binding protein beta polypeptide 3 (GNB3) gene is currently inconsistent. In this study, we aimed to reassess whether the GNB3 rs5443 single nucleotide polymorphism could influence weight reduction and body composition change under sibutramine therapy in 131 obese Taiwanese patients. By comparing the sibutramine and placebo groups with analysis of covariance, our data showed a strong effect of sibutramine on weight reduction (7.4+/-1.4 vs. 3.4+/-1.2 kg; P<0.001) and on body fat percentage loss (4.2+/-0.1 vs. 2.1+/-0.1%; P<0.001) in the combined TT+TC carriers. In contrast, sibutramine caused no significant additional effect on weight loss (P = 0.078) or on body fat percentage loss (P = 0.441) in homozygous C allele carriers.
Hsiao
Dun-Jen
DJ
College of Public Health and Nutrition, Taipei Medical University, Taipei, Taiwan.
Wu
Lawrence Shih-Hsin
LS
Huang
Shih-Yi
SY
Lin
Eugene
E
D000273:Adipose Tissue / Q000187:drug effects*; D000293:Adolescent; D000328:Adult; D000368:Aged; D001067:Appetite Depressants / Q000627:therapeutic use*; D015992:Body Mass Index; D003503:Cyclobutanes / Q000627:therapeutic use*; D005260:Female; D020962:Heterotrimeric GTP-Binding Proteins / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000188:drug therapy* / Q000235:genetics; D010919:Placebos; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D013624:Taiwan; D015431:Weight Loss / Q000187:drug effects* / Q000235:genetics; D055815:Young Adult
D001067:Appetite Depressants; D003503:Cyclobutanes; C454420:G-protein beta3 subunit; D010919:Placebos; D020962:Heterotrimeric GTP-Binding Proteins; C058254:sibutramine