title: High-dose chemotherapy with autologous peripheral blood stem cell support for recurrent primary AFP-producing intracranial germinoma.
abstract: We report of a 34-year old man with second intracranial relapse of a suprasellar germinoma. Despite of extensive pretreatment with radiation and conventional chemotherapy relapse occurred and was treated with sequential high-dose chemotherapy followed by transfusion of autologous peripheral stem cells. The high-dose chemotherapy course was complicated by refractory derailment of pineal gland insufficiency. The patient achieved a complete remission after high dose chemotherapy which lasted for 13 months. Subsequently, he developed a third relapse and died.
authors.affiliation: Medizinische Klinik und Poliklinik I, Rheinische Friedrich-Wilhelms-Universität, Bonn, Germany.
authors.forename: Carsten
authors.initials: C
authors.lastname: Ziske
authors.forename: Jörg
authors.initials: J
authors.lastname: Mezger
authors.forename: Carlos
authors.initials: C
authors.lastname: Jiménez
authors.forename: Rolf
authors.initials: R
authors.lastname: Kleinschmidt
authors.forename: Hendrik
authors.initials: H
authors.lastname: Pels
authors.forename: Uwe
authors.initials: U
authors.lastname: Schlegel
authors.forename: Ingo G H
authors.initials: IG
authors.lastname: Schmidt-Wolf
references.citation: Int J Radiat Oncol Biol Phys. 1995 Jul 15;32(4):943-9
references.pmid: 7607968
references.citation: J Neurosurg. 1987 Jul;67(1):65-70
references.pmid: 2439668
references.citation: J Clin Oncol. 1994 Jun;12(6):1223-31
references.pmid: 7911158
references.citation: Nihon Naika Gakkai Zasshi. 1995 Jan 10;84(1):132-4
references.pmid: 7722358
references.citation: J Clin Oncol. 1997 May;15(5):1814-23
references.pmid: 9164190
references.citation: J Neurosurg. 1987 Jan;66(1):1-22
references.pmid: 3023563
references.citation: Prog Exp Tumor Res. 1987;30:307-12
references.pmid: 2819945
references.citation: Prog Exp Tumor Res. 1987;30:281-8
references.pmid: 3306798