title: Design and synthesis of novel substituted quinazoline derivatives as antileishmanial agents.
abstract: 4-(Substituted-benzylidine)-2-substituted-5,6-dihydrobenzo[h]quinazoline (5a-p) and 4-(substituted-benzylidine)-2-substituted-3, 4, 5, 6-tetrahydrobenzo[h]quinazoline (6a-p) have been synthesized from 2-(substituted-benzylidine)tetralone-1(3a-d) and several substituted guanidine sulfates(4a-d).These compounds were tested for their in vitro antileishmanial activity. The compounds 6i, 6f, 6g show promising antileishmanial activity against Leishmania donovani.
authors.affiliation: Division of Medicinal & Process Chemistry, Central Drug Research Institute, Lucknow 226001, India. kcagarwal@rediffmail.com
authors.forename: K C
authors.initials: KC
authors.lastname: Agarwal
authors.forename: Vidisha
authors.initials: V
authors.lastname: Sharma
authors.forename: Nishi
authors.initials: N
authors.lastname: Shakya
authors.forename: Suman
authors.initials: S
authors.lastname: Gupta
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D007893:Leishmania donovani / Q000187:drug effects*; D021261:Parasitic Sensitivity Tests; D011799:Quinazolines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000981:Antiprotozoal Agents; D011799:Quinazolines