title: French cohort of the uranium processing workers: mortality pattern after 30-year follow-up.
abstract: OBJECTIVE
  To investigate mortality among nuclear workers with potential internal exposure to uranium.
  
  
  METHODS
  The cohort included 2,709 workers employed at the AREVA NC Pierrelatte plant for at least 6 months (72,787 person-years). This plant processed uranium enrichment during the period 1960-1996 and chemical conversion since 1980. Mortality was compared to the national and regional mortality rates available for the period 1968-2005. For causes of death of interest with respect to occupational exposure, mortality trends according to occupational characteristics were assessed.
  
  
  RESULTS
  As expected, an important healthy worker effect (all causes SMR = 0.55 (95% CI: 0.50-0.61), n = 411; all cancers SMR = 0.70 (95% CI: 0.60-0.81), n = 193) was observed. Among cancer sites a priori related to uranium exposure, only mortality for lymphatic cancer was increased among potentially exposed workers (SMR = 1.49 (95% CI: 0.68-2.82); n = 9). An important increase in mortality from pleural cancer was observed (SMR = 2.85 (95% CI: 0.93-6.66), n = 5); none of the deceased workers were exposed to radiation whereas all handled asbestos.
  
  
  CONCLUSIONS
  In spite of limited statistical power, results show consistency with previous studies of nuclear workers potentially exposed to uranium. Further investigation based on more precise uranium exposure data should allow the estimation of uranium hazard effects among this cohort.
authors.affiliation: Institut de Radioprotection et de Sûreté Nucléaire, Service de Radiobiologie et d'Epidémiologie, BP 17, 92262, Fontenay-aux-Roses, France. irina.canu@irsn.fr
authors.forename: Irina
authors.initials: I
authors.lastname: Guseva Canu
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Cardis
authors.forename: Camille
authors.initials: C
authors.lastname: Metz-Flamant
authors.forename: Sylvaine
authors.initials: S
authors.lastname: Caër-Lorho
authors.forename: Bernard
authors.initials: B
authors.lastname: Auriol
authors.forename: Pascal
authors.initials: P
authors.lastname: Wild
authors.forename: Dominique
authors.initials: D
authors.lastname: Laurier
authors.forename: Margot
authors.initials: M
authors.lastname: Tirmarche
mesh_terms: D000328:Adult; D015331:Cohort Studies; D005602:France / Q000453:epidemiology; D006801:Humans; D008297:Male; D009026:Mortality / Q000639:trends*; D009369:Neoplasms / Q000145:classification / Q000453:epidemiology*; D055848:Nuclear Power Plants; D016273:Occupational Exposure / Q000009:adverse effects*; D014501:Uranium / Q000008:administration & dosage* / Q000009:adverse effects; D055815:Young Adult
chemical_list: D014501:Uranium
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