title: A division of labor: asymmetric roles for GPCR subunits in receptor dimers.
abstract: The functional architecture of dimeric or oligomeric GPCR signaling remains incompletely understood. Using a clever combination of receptor-G protein fusions and various receptor mutations, new research provides a glimpse into how oligomers might be arranged with respect to the G proteins they interact with.
authors.affiliation: Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada.
authors.forename: Peter
authors.initials: P
authors.lastname: Zylbergold
authors.forename: Terence E
authors.initials: TE
authors.lastname: Hébert
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D008024:Ligands; D011485:Protein Binding; D055503:Protein Multimerization; D021122:Protein Subunits; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism* / Q000502:physiology*; D015398:Signal Transduction
chemical_list: D008024:Ligands; D021122:Protein Subunits; D043562:Receptors, G-Protein-Coupled
references.citation: FEBS J. 2005 Jun;272(12):2947-55
references.pmid: 15955055
references.citation: Annu Rev Pharmacol Toxicol. 2009;49:31-56
references.pmid: 18834311
references.citation: Mol Pharmacol. 2007 Dec;72(6):1393-401
references.pmid: 17901198
references.citation: J Biol Chem. 2008 Feb 15;283(7):4387-94
references.pmid: 18033822
references.citation: Nat Chem Biol. 2009 Sep;5(9):688-95
references.pmid: 19648932
references.citation: Biochem Biophys Res Commun. 2008 Sep 12;374(1):128-33
references.pmid: 18601900
references.citation: J Cell Sci. 2006 Jul 1;119(Pt 13):2807-18
references.pmid: 16787947
references.citation: J Mol Biol. 2003 Jun 13;329(4):815-29
references.pmid: 12787680
references.citation: Proc Natl Acad Sci U S A. 2007 May 1;104(18):7682-7
references.pmid: 17452637
references.citation: Biochemistry. 2007 Jul 3;46(26):7907-27
references.pmid: 17552496
references.citation: Br J Pharmacol. 2009 Mar;156(6):869-84
references.pmid: 19298394