title: Synthesis of antitumor marine alkaloid discorhabdin A oxa analogues.
abstract: Discorhabdin A (1) exhibits a strong cytotoxic activity in vitro, but it is difficult to synthesize and handle due to the instability of its highly strained N,S-acetal structure. We then designed the analogues of discorhabdin A which also have strong cytotoxic activity and stability. The synthesis and examination of the biological activity of various types of stable discorhabdin A oxa analogues (2) were achieved.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka 565-0871, Japan.
authors.forename: Yasufumi
authors.initials: Y
authors.lastname: Wada
authors.forename: Kouji
authors.initials: K
authors.lastname: Otani
authors.forename: Noriko
authors.initials: N
authors.lastname: Endo
authors.forename: Yu
authors.initials: Y
authors.lastname: Harayama
authors.forename: Daigo
authors.initials: D
authors.lastname: Kamimura
authors.forename: Masako
authors.initials: M
authors.lastname: Yoshida
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Fujioka
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Kita
mesh_terms: D000080:Acetals; D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry; D004354:Drug Screening Assays, Antitumor; D008386:Marine Biology; D010121:Oxytocin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D011809:Quinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013841:Thiazepines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000080:Acetals; D000470:Alkaloids; D000970:Antineoplastic Agents; D011809:Quinones; D013141:Spiro Compounds; D013841:Thiazepines; C471812:discorhabdin A; D010121:Oxytocin; C015692:oxytocin, Asp(5)-