Mutagenic Activity of Indigofera truxillensis and I. suffruticosa Aerial Parts.
Indigofera truxillensis and I. suffruticosa, are used as a source of indigo dye and to treat several diseases. The mutagenic activity of the methanolic extracts from aerial parts, glycerolipid, flavonoid and alkaloid fractions of the extract were evaluated by means of Salmonella/microsome assays using TA100, TA98, TA102 and TA97a strains. The methanolic extract of I. truxillensis showed mutagenic activity in the TA98 strain without S9 while glycerolipid fraction was devoid of activity. The flavonoid and alkaloid fractions of both plants showed mutagenicity. Chemical analysis of flavonoid fractions of I. truxillensis and I. suffruticosa resulted in the identification of kaempferol, quercetin and their derivatives. The alkaloid fraction of both the species contained indigo and indirubin and indigo was found mainly responsible for the mutagenic activity.
Calvo
Tamara Regina
TR
Departamento de Química Orgânica, Instituto de Química de Araraquara, UNESP-São Paulo State University, c.p. 355, CEP 14800-900, Brazil.
Cardoso
Cássia Regina Primila
CR
da Silva Moura
Adriana Candido
AC
Dos Santos
Lourdes Campaner
LC
Colus
Ilce Mara Syllos
IM
Vilegas
Wagner
W
Varanda
Eliana Aparecida
EA
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