title: Colomitides A and B: novel ketals with an unusual 2,7-dioxabicyclo[3.2.1]octane ring system from the aquatic fungus YMF 1.01029.
abstract: Two novel diastereoisomeric bicyclic ketals, colomitides A and B (1 and 2, resp.), together with the known (4RS)-3,4-dihydro-4,8-dihydroxynaphthalen-1(2H)-one (3) and preussomerin E (4), were isolated from liquid cultures of an unidentified freshwater fungus YMF 1.01029. Colomitides possess an unusual 2,7-dioxabicyclo[3.2.1]octane skeleton. The chemical structures and relative configurations of compounds 1 and 2 were elucidated by spectroscopic means, including 2D-NMR (HMBC, HMQC, TOCSY, ROESY, and (1)H,(1)H-COSY). Compounds 1, 2, and 4 showed noticeable antifungal and antibacterial activities.
authors.affiliation: Laboratory for Conservation and Utilization of Bio-Resources, Yunnan University, Kunming, PR China.
authors.forename: Jin-Yan
authors.initials: JY
authors.lastname: Dong
authors.forename: Li-Mei
authors.initials: LM
authors.lastname: Wang
authors.forename: Hong-Chuang
authors.initials: HC
authors.lastname: Song
authors.forename: Kai-Ze
authors.initials: KZ
authors.lastname: Shen
authors.forename: Yong-Ping
authors.initials: YP
authors.lastname: Zhou
authors.forename: Le
authors.initials: L
authors.lastname: Wang
authors.forename: Ke-Qin
authors.initials: KQ
authors.lastname: Zhang
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D005658:Fungi / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D019086:Bridged Bicyclo Compounds, Heterocyclic; C544755:colomitide A; C544756:colomitide B