Frequency and clinical features of intraocular inflammation in Tokyo.
BACKGROUND
To investigate frequencies and clinical features of intraocular inflammation (uveitis) in Tokyo, Japan.


METHODS
Records of 834 consecutive new referral patients (352 men, 482 women) examined at the Kyorin University Hospital from April 2000 to December 2007 were retrospectively reviewed.


RESULTS
Mean age at onset was 44.8 years for men and 47.0 years for women. By anatomical classification, 229 patients (27.4%) had anterior uveitis, 10 (1.2%) had intermediate uveitis, 183 (21.9%) had posterior uveitis and 412 (49.4%) had panuveitis. The most common diagnoses were Vogt-Koyanagi-Harada (VKH) disease (11.0%), sarcoidosis (6.9%), acute anterior uveitis (6.5%), Behçet's disease (5.8%) and tuberculosis (4.3%). In the third and fourth decades, the most common diseases were Behçet's disease for men and VKH for women, whereas over 60 years of age, the most common diseases were VKH for men and sarcoidosis for women. Systemic corticosteroids were used in 25.5% of patients, and other immunomodulatory agents were required in 8.7% of patients.


CONCLUSIONS
The most frequent diagnoses were sarcoidosis, VKH disease, acute anterior uveitis, Behçet's disease and tuberculosis, with Behçet's disease being common in young men and sarcoidosis being common in elderly women. One-fourth of patients received systemic corticosteroids and 8.7% of patients required other immunomodulatory agents.
Keino
Hiroshi
H
Department of Ophthalmology, Kyorin University School of Medicine, Mitaka, Tokyo, Japan.
Nakashima
Chikae
C
Watanabe
Takayo
T
Taki
Wakako
W
Hayakawa
Ruriko
R
Sugitani
Atsuhiko
A
Okada
Annabelle A
AA
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D017678:Sex Distribution; D014041:Tokyo / Q000453:epidemiology; D014605:Uveitis / Q000145:classification / Q000175:diagnosis* / Q000453:epidemiology*