title: Compression strength and porosity of single-antibiotic cement vacuum-mixed with vancomycin.
abstract: We evaluated the ultimate compression strength (UCS), porosity, and fracture surface roughness of 2 commercially available single-antibiotic bone cements vacuum-mixed with additional amounts of vancomycin (2, 4, 6, and 8 g). At least 8 g could be added to Palacos R + 0.5 g gentamicin (UCS = 75.04 +/- 6.64 MPa) and no more than 6 g to Simplex P + 1 g tobramycin (UCS = 78.93 +/- 4.98 MPa) to maintain a UCS above the International Organization for Standardization minimum standard (70 MPa). Increasing vancomycin concentration correlated with a decrease in porosity but showed a trend towards greater fracture surface roughness.
authors.affiliation: Department of Orthopedic Surgery, The University of Kansas Medical Center, Kansas City, USA.
authors.forename: Hugh S
authors.initials: HS
authors.lastname: Brock
authors.forename: Patrick G
authors.initials: PG
authors.lastname: Moodie
authors.forename: Kelly J
authors.initials: KJ
authors.lastname: Hendricks
authors.forename: Terence E
authors.initials: TE
authors.lastname: McIff
mesh_terms: D019643:Arthroplasty, Replacement; D001843:Bone Cements; D019245:Compressive Strength; D005839:Gentamicins; D006801:Humans; D020366:Methylmethacrylate; D008855:Microscopy, Electron, Scanning; D019904:Polymethyl Methacrylate; D016062:Porosity; D016459:Prosthesis-Related Infections / Q000517:prevention & control; D013499:Surface Properties; D014031:Tobramycin; D014618:Vacuum; D014640:Vancomycin
chemical_list: D001843:Bone Cements; D005839:Gentamicins; D020366:Methylmethacrylate; D014640:Vancomycin; D019904:Polymethyl Methacrylate; D014031:Tobramycin