Clinical evaluation of a (1,3)-beta-D-glucan assay for presumptive diagnosis of Pneumocystis jiroveci pneumonia in immunocompromised patients.
(1,3)-beta-d-Glucan (BG) is a component of the Pneumocystis jiroveci cell wall. Thirty-one immunocompromised patients with pneumonia (16 with presumptive pneumocystis pneumonia [PCP] and 15 with non-PCP) were evaluated for serum BG levels. Serum from all 16 presumptive PCP patients and from 2/15 patients with non-PCP was positive for BG. Results indicate that BG is a reliable marker for diagnosing PCP.
Del Bono
Valerio
V
Clinica Malattie Infettive, Azienda Ospedaliera Universitaria San Martino, Genoa, Italy. valerio.delbono@hsanmartino.it
Mularoni
Alessandra
A
Furfaro
Elisa
E
Delfino
Emanuele
E
Rosasco
Lorenzo
L
Miletich
Franca
F
Viscoli
Claudio
C
D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002473:Cell Wall / Q000737:chemistry; D006801:Humans; D016867:Immunocompromised Host; D045363:Pneumocystis carinii / Q000276:immunology / Q000302:isolation & purification; D011020:Pneumonia, Pneumocystis / Q000175:diagnosis* / Q000276:immunology / Q000382:microbiology; D011509:Proteoglycans; D047071:beta-Glucans / Q000097:blood*
D015415:Biomarkers; D011509:Proteoglycans; D047071:beta-Glucans; C010770:polysaccharide-K
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