title: CDK4 IVS4-nt40G-->A SNP and type 2 diabetes in Italians.
abstract: As cyclin-dependant kinase 4 (CDK4) regulates beta cell proliferation, it may confer T2D risk. We tested the CDK4 IVS4-nt40A-->G SNP for association with T2D in Italians (230 cases, 204 control subjects) and excluded a role of the variant in our dataset.
authors.affiliation: Department of Medicine and Cellular & Molecular Physiology, Biostatistics, Milton S Hershey Medical Center, Hershey, PA 17033, United States.
authors.forename: Ramachandran
authors.initials: R
authors.lastname: Meenakshisundaram
authors.forename: Nunzia
authors.initials: N
authors.lastname: Piumelli
authors.forename: Laura
authors.initials: L
authors.lastname: Pierpaoli
authors.forename: Claudia
authors.initials: C
authors.lastname: Gragnoli
mesh_terms: D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D002453:Cell Cycle; D002455:Cell Division; D051358:Cyclin-Dependent Kinase 4 / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000201:enzymology / Q000235:genetics* / Q000473:pathology; D005838:Genotype; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D050417:Insulin-Secreting Cells / Q000473:pathology; D007558:Italy; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012016:Reference Values
chemical_list: D001786:Blood Glucose; D051358:Cyclin-Dependent Kinase 4; D006442:Glycated Hemoglobin; C495900:CDK4 protein, human