Membrane oestrogen receptor alpha signalling to cell functions.
Conservation of steroid hormone action outside the nucleus occurs from plants that make brassinosteroids to higher metazoans (primates). In plants, steroid hormone action occurs when the brassinosteroids bind a membrane tyrosine kinase receptor. Ligated receptors for all sex steroids exist at the plasma membrane and rapidly signal through G proteins to second messengers including calcium, cAMP and cGMP, activating proximal and more distal kinases. These signal cascades impact many functions of steroid hormones, responsible for the biological actions of these molecules. Support also exists for membrane-localized receptors of other members of the steroid superfamily, responding to glucocorticoids, mineralocorticoids, thyroid hormone, and vitamin D. The nature of these receptors is in some cases unclear. Steroid receptors also exist in discrete cytoplasmic organelles, most notably the mitochondria, although the functions of these receptors are poorly understood. In this review, I highlight the essential elements of the membrane oestrogen receptor alpha, noting where conserved aspects exist for other steroid receptors.
Levin
Ellis R
ER
Division of Endocrinology, Veterans Affairs Medical Center, Long Beach, Long Beach, CA 90822, USA. ellis.levin@med.va.gov
D000818:Animals; D002462:Cell Membrane / Q000502:physiology*; D047628:Estrogen Receptor alpha / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D015398:Signal Transduction / Q000502:physiology*
D047628:Estrogen Receptor alpha
Endocrinology. 1999 Aug;140(8):3805-14
10433242
J Biol Chem. 2006 Mar 10;281(10):6760-7
16407188
Endocrinology. 2008 Jul;149(7):3361-9
18372323
Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):11162-6
8248223
Mol Cell Biol. 2003 Mar;23(5):1633-46
12588983
Nature. 1977 Jan 6;265(5589):69-72
834244
Mol Biol Cell. 2009 Jul;20(14):3374-89
19477925
J Biol Chem. 2007 Aug 3;282(31):22278-88
17535799
J Biol Chem. 2005 May 20;280(20):19704-10
15764600
Endocrinology. 2009 Apr;150(4):1563-5
19307418
Mol Endocrinol. 2009 Mar;23(3):349-59
19131510
Mol Endocrinol. 2006 Sep;20(9):1996-2009
16645038
Endocr Rev. 2007 Dec;28(7):726-41
17916740
Endocrinology. 2008 Oct;149(10):4846-56
18566127
Mol Endocrinol. 2002 Jan;16(1):100-15
11773442
Mol Biol Cell. 2005 Jan;16(1):231-7
15496458
Mol Endocrinol. 2000 Oct;14(10):1649-60
11043579
Mol Endocrinol. 2005 Apr;19(4):833-42
15695368
Mol Endocrinol. 2007 Jun;21(6):1370-80
17405905
Nature. 2004 Nov 18;432(7015):316-23
15549093
Biochem Biophys Res Commun. 1999 Sep 16;263(1):257-62
10486286
Mol Endocrinol. 2002 May;16(5):938-46
11981029
J Biol Chem. 2009 Feb 6;284(6):3488-95
19054762
Proc Natl Acad Sci U S A. 1967 Oct;58(4):1711-8
4295833
Mol Endocrinol. 1999 Feb;13(2):307-19
9973260
Annu Rev Biochem. 2004;73:39-85
15189136
J Biol Chem. 2005 Jul 15;280(28):26339-48
15899894
Science. 2005 Mar 11;307(5715):1625-30
15705806