title: Hippocampal volume and declarative memory function in combat-related PTSD.
abstract: The proposition that declarative memory deficits are systematically related to smaller hippocampal volume was tested in a relatively large sample (n = 95) of U.S. military veterans with and without combat-related posttraumatic stress disorder. This correlative analysis was extended by including multiple measures of verbal and visual declarative memory and multiple memory-relevant regional brain volumes that had been shown to exhibit main effects of PTSD in prior work. Small-to-moderate effects were observed on verbal declarative memory in line with a recent meta-analysis; nevertheless, little or no evidence of systematic linear covariation between memory measures and brain volumes was observed.
authors.affiliation: Dissemination and Training Division, National Center for PTSD, VA Palo Alto Health Care System, Palo Alto, CA 94304, USA. steve.woodward@va.gov
authors.forename: Steven H
authors.initials: SH
authors.lastname: Woodward
authors.forename: Danny G
authors.initials: DG
authors.lastname: Kaloupek
authors.forename: Laura J
authors.initials: LJ
authors.lastname: Grande
authors.forename: Wendy K
authors.initials: WK
authors.lastname: Stegman
authors.forename: Catherine J
authors.initials: CJ
authors.lastname: Kutter
authors.forename: Loraine
authors.initials: L
authors.lastname: Leskin
authors.forename: Rebecca
authors.initials: R
authors.lastname: Prestel
authors.forename: Marie
authors.initials: M
authors.lastname: Schaer
authors.forename: Allan L
authors.initials: AL
authors.lastname: Reiss
authors.forename: Stephan
authors.initials: S
authors.lastname: Eliez
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000150:complications / Q000473:pathology; D000704:Analysis of Variance; D001931:Brain Mapping; D003130:Combat Disorders / Q000150:complications*; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D007858:Learning / Q000502:physiology; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008569:Memory Disorders / Q000209:etiology*; D008875:Middle Aged; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D011594:Psychometrics; D013223:Statistics as Topic; D013313:Stress Disorders, Post-Traumatic / Q000150:complications*; D014728:Veterans