Hemodynamic effects of ropivacaine and levobupivacaine intravenous injection in swines.
OBJECTIVE
To compare the hemodynamic effects following a toxic dose of either agent after intravenous injection in swines, as might accidentally occur during regional anesthesia in humans.


METHODS
Large White pigs were anesthetized with thiopental, tracheal intubation was performed and mechanical ventilation was instituted. Hemodynamic variables were recorded with invasive pressure monitoring and pulmonary artery catheterization. After a 30-minute resting period, the animals were randomly divided into two groups in a double-blinded fashion and received a bolus intravenous injection of 4 mg.kg-1 of either agent. Hemodynamic results were evaluated at rest and 1, 5, 10, 15, 20 and 30 minutes after intoxication.


RESULTS
Hemodynamic repressions of acute intoxication with levobupivacaine were more important and more prolonged than those of ropivacaína.


CONCLUSIONS
In pigs, levobupivacaine was shown to be more toxic than ropivacaine when the same large doses are injected intravenously.
Udelsmann
Artur
A
Department of Anesthesiology and Laboratory of Experimental Anesthesia, UNICAMP, Sao Paulo, Brazil. audelsmann@yahoo.com.br
Silva
William Adalberto
WA
Moraes
Ana Cristina de
AC
Dreyer
Elisabeth
E
D000577:Amides / Q000008:administration & dosage / Q000633:toxicity*; D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000633:toxicity*; D000779:Anesthetics, Local / Q000008:administration & dosage / Q000633:toxicity*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D002045:Bupivacaine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000633:toxicity; D016009:Chi-Square Distribution; D004195:Disease Models, Animal; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D007275:Injections, Intravenous; D000077554:Levobupivacaine; D008297:Male; D011651:Pulmonary Artery / Q000503:physiopathology; D011897:Random Allocation; D000077212:Ropivacaine; D013552:Swine; D013874:Thiopental / Q000008:administration & dosage; D013997:Time Factors
D000577:Amides; D018686:Anesthetics, Intravenous; D000779:Anesthetics, Local; D000077212:Ropivacaine; D000077554:Levobupivacaine; D013874:Thiopental; D002045:Bupivacaine