title: Taste-potentiated odor aversion learning in rats with lesions of the insular cortex.
abstract: The current study assessed the influence of excitotoxic lesions of the insular cortex (IC) on taste-potentiated odor aversion (TPOA) learning. Water-deprived rats initially received a single odor-toxicosis or odor/taste-toxicosis pairing and were subsequently tested, in separate trials, with the odor and the taste stimulus. Indicating TPOA, neurologically intact rats conditioned with the odor/taste compound stimulus acquired significantly stronger odor aversions than normal rats conditioned with the odor stimulus. IC lesions disrupted TPOA, conditioned taste aversion and taste neophobia. The finding that taste did not potentiate odor aversion learning in the IC-lesioned rats provides support for the "within-compound association" analysis but is inconsistent with the "sensory-and-gate" account of TPOA learning.
authors.affiliation: Department of Psychology, University of Illinois at Chicago, 1007 West Harrison Street, Chicago, IL 60607, USA.
authors.forename: Jian-You
authors.initials: JY
authors.lastname: Lin
authors.forename: Christopher
authors.initials: C
authors.lastname: Roman
authors.forename: Steve
authors.initials: S
authors.lastname: Reilly
mesh_terms: D000818:Animals; D001245:Association Learning / Q000502:physiology; D001362:Avoidance Learning / Q000502:physiology*; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000033:anatomy & histology / Q000502:physiology*; D003714:Denervation; D008297:Male; D009473:Neuronal Plasticity / Q000502:physiology; D009483:Neuropsychological Tests; D009812:Odorants; D009833:Olfactory Pathways / Q000502:physiology; D010812:Physical Stimulation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012903:Smell / Q000502:physiology*; D013194:Staining and Labeling; D013649:Taste / Q000502:physiology*; D014868:Water Deprivation / Q000502:physiology
references.citation: Ann N Y Acad Sci. 1985;443:8-21
references.pmid: 3860080
references.citation: Eur J Neurosci. 2009 Apr;29(8):1654-62
references.pmid: 19419428
references.citation: Neurosci Res. 2000 Apr;36(4):297-309
references.pmid: 10771108
references.citation: Q J Exp Psychol B. 1983 Feb;35 (Pt 1):13-33
references.pmid: 6682563
references.citation: Physiol Behav. 1985 Jan;34(1):71-7
references.pmid: 4034697
references.citation: Brain Res. 2009 Mar 9;1259:68-73
references.pmid: 19150440
references.citation: Learn Motiv. 1996 Nov;27(4):335-61
references.pmid: 8979936
references.citation: J Comp Physiol Psychol. 1977 Jun;91(3):498-507
references.pmid: 874118
references.citation: J Comp Neurol. 1998 Oct 5;399(4):440-68
references.pmid: 9741477
references.citation: J Comp Neurol. 1968 Apr;132(4):519-30
references.pmid: 5666494
references.citation: Brain Res. 1986 Aug 6;379(2):329-41
references.pmid: 3742225
references.citation: Behav Neurosci. 2006 Dec;120(6):1257-67
references.pmid: 17201470
references.citation: Behav Neurosci. 1993 Dec;107(6):1005-17
references.pmid: 8136054
references.citation: Brain Res. 2009 Jan 28;1251:195-203
references.pmid: 19059225
references.citation: J Exp Anal Behav. 1966 Jul;9(4):469-73
references.pmid: 4960162
references.citation: J Neurosci Methods. 1989 Sep;29(3):251-9
references.pmid: 2477650
references.citation: J Exp Psychol Anim Behav Process. 1980 Apr;6(2):175-87
references.pmid: 7373231
references.citation: Eur J Neurosci. 2007 Nov;26(9):2627-32
references.pmid: 17970726
references.citation: Brain Res. 1975 Jul 4;92(1):123-9
references.pmid: 1174938
references.citation: Learn Mem. 2004 Sep-Oct;11(5):485-94
references.pmid: 15466298
references.citation: J Comp Neurol. 1976 Mar 1;166(1):17-30
references.pmid: 1262547
references.citation: Brain Res. 1974 Feb 15;67(1):169-74
references.pmid: 4470415
references.citation: Behav Neural Biol. 1979 Jan;25(1):1-17
references.pmid: 454334
references.citation: Brain Res. 1986 Aug 6;379(2):342-52
references.pmid: 3742226
references.citation: Am J Psychol. 1986 Summer;99(2):145-218
references.pmid: 2876652
references.citation: Behav Neurosci. 2006 Jun;120(3):590-9
references.pmid: 16768611
references.citation: Science. 1980 May 16;208(4445):753-5
references.pmid: 7367891
references.citation: Learn Behav. 2004 Nov;32(4):440-53
references.pmid: 15825885
references.citation: Physiol Behav. 1996 Aug;60(2):331-9
references.pmid: 8840888
references.citation: J Comp Neurol. 1987 Aug 1;262(1):27-45
references.pmid: 2442207
references.citation: Hippocampus. 2002;12(3):405-14
references.pmid: 12099491
references.citation: J Comp Neurol. 1977 Jan 15;171(2):157-91
references.pmid: 64477