Group II metabotropic glutamate receptors and schizophrenia.
Schizophrenia is one of the most common mental illnesses, with hereditary and environmental factors important for its etiology. All antipsychotics have in common a high affinity for monoaminergic receptors. Whereas hallucinations and delusions usually respond to typical (haloperidol-like) and atypical (clozapine-like) monoaminergic antipsychotics, their efficacy in improving negative symptoms and cognitive deficits remains inadequate. In addition, devastating side effects are a common characteristic of monoaminergic antipsychotics. Recent biochemical, preclinical and clinical findings support group II metabotropic glutamate receptors (mGluR2 and mGluR3) as a new approach to treat schizophrenia. This paper reviews the status of general knowledge of mGluR2 and mGluR3 in the psychopharmacology, genetics and neuropathology of schizophrenia.
Moreno
José L
JL
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA.
Sealfon
Stuart C
SC
González-Maeso
Javier
J
D000818:Animals; D014150:Antipsychotic Agents / Q000493:pharmacokinetics; D006801:Humans; D051379:Mice; D008954:Models, Biological; D018094:Receptors, Metabotropic Glutamate / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D012559:Schizophrenia / Q000378:metabolism*
D014150:Antipsychotic Agents; D018094:Receptors, Metabotropic Glutamate; C108822:metabotropic glutamate receptor 2; C102718:metabotropic glutamate receptor 3
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