title: Enamides and enesulfonamides as nucleophiles: formation of complex ring systems through a platinum(II)-catalyzed addition/Friedel-Crafts pathway.
abstract: Cyclic enamine derivatives (enesulfonamides and enamides) tethered to an 1-arylalkynyl fragment undergo a platinum(II)-catalyzed tandem alkyne addition/Friedel-Crafts ring closure to form nitrogen-containing polycyclic structures. Regioselectivity in the initial addition of the enesulfonamide or enamide nucleophile to the platinum(II)-alkyne complex is important. Electron-rich arenes and heterocycles led to the formation of products resulting from an initial 6-endo cyclization. Twenty-three examples of this process are presented.
authors.affiliation: Department of Chemistry, 2036 Main Mall, University of British Columbia, Vancouver, BC, Canada V6T 1Z1.
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Kozak
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: Dodd
authors.forename: Tyler J
authors.initials: TJ
authors.lastname: Harrison
authors.forename: Katherine J
authors.initials: KJ
authors.lastname: Jardine
authors.forename: Brian O
authors.initials: BO
authors.lastname: Patrick
authors.forename: Gregory R
authors.initials: GR
authors.lastname: Dake