title: Physical and psychosocial functioning following motor vehicle trauma: relationships with chronic pain, posttraumatic stress, and medication use.
abstract: Chronic pain and PTSD are known to hold substantial comorbidity following traumatic injury. Although pharmacological agents have been examined in the treatment of pain and PTSD individually, little is known regarding the relationship of medication use with functioning in patients with comorbid conditions. This research examined the relationships of pain, PTSD, and medication use across physical and psychosocial functioning in patients with chronic pain following motor vehicle injury (N=234). Separate analyses were conducted for opioids, SSRIs, and sedative/anxiolytics, respectively. Several relevant effects were noted: (1) Pain evidenced strong associations with reduced functioning across both physical and psychosocial domains, (2) Opioid use held interactive relationships with PTSD across both functioning domains. Specifically, opioids were associated with greater physical impairment in patients without comorbid PTSD. Opioids also were related to greater psychosocial impairment in patients without PTSD while PTSD was associated with greater impairment in patients not using opioids, (3) Opioid use evidenced a marginal interaction with pain on psychosocial functioning. Opioids were associated with greater psychosocial impairment among patients with high-pain, and high-pain was associated with greater impairment among opioid users, (4) SSRIs held a marginal interaction with PTSD such that PTSD was related to poorer psychosocial functioning only among individuals not using an SSRI, and (5) Anxiolytic use evidenced a marginal interaction with PTSD on physical functioning although no between-group differences were noted. These data suggest that PTSD symptomology may be an important consideration in determining treatment modality for patients experiencing pain subsequent to traumatic injury.
authors.affiliation: University at Buffalo - SUNY, Department of Psychology, Park Hall, Buffalo, NY 14260, United States.
authors.forename: Joshua D
authors.initials: JD
authors.lastname: Clapp
authors.forename: Jarod
authors.initials: J
authors.lastname: Masci
authors.forename: Shira A
authors.initials: SA
authors.lastname: Bennett
authors.forename: J Gayle
authors.initials: JG
authors.lastname: Beck
mesh_terms: D000063:Accidents, Traffic; D000328:Adult; D000701:Analgesics, Opioid / Q000627:therapeutic use*; D014151:Anti-Anxiety Agents / Q000627:therapeutic use; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010146:Pain / Q000473:pathology* / Q000523:psychology*; D010147:Pain Measurement; D011569:Psychiatric Status Rating Scales; D020127:Recovery of Function; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use; D012919:Social Behavior; D012959:Socioeconomic Factors; D013313:Stress Disorders, Post-Traumatic / Q000188:drug therapy / Q000523:psychology*; D017741:Survivors; D014947:Wounds and Injuries / Q000473:pathology* / Q000523:psychology*
chemical_list: D000701:Analgesics, Opioid; D014151:Anti-Anxiety Agents; D017367:Selective Serotonin Reuptake Inhibitors
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