title: Lumcorin: a leucine-rich repeat 9-derived peptide from human lumican inhibiting melanoma cell migration.
abstract: We previously showed that lumican decreases melanoma progression. The aim of the present study was to determine the active sequence of the lumican core protein responsible for the inhibition of melanoma cell migration. Using different recombinant and synthetic peptides derived from lumican, we localized an active site in the leucine-rich repeat 9 domain of the lumican core protein. We propose the name lumcorin (fragment of lumican core protein) for the active peptide derived from this site. Lumcorin was able to inhibit melanoma cell migration in vitro.
authors.affiliation: Laboratoire de Biochimie Médicale et de Biologie Moléculaire, CNRS UMR 6237, Université Reims-Champagne-Ardenne, F-51095 Reims, France.
authors.forename: Cédric
authors.initials: C
authors.lastname: Zeltz
authors.forename: Stéphane
authors.initials: S
authors.lastname: Brézillon
authors.forename: Corinne
authors.initials: C
authors.lastname: Perreau
authors.forename: Laurent
authors.initials: L
authors.lastname: Ramont
authors.forename: François-Xavier
authors.initials: FX
authors.lastname: Maquart
authors.forename: Yanusz
authors.initials: Y
authors.lastname: Wegrowski
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D020134:Catalytic Domain; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D011508:Chondroitin Sulfate Proteoglycans / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D007632:Keratan Sulfate / Q000737:chemistry* / Q000627:therapeutic use; D000071234:Lumican; D008545:Melanoma / Q000188:drug therapy* / Q000473:pathology; D010446:Peptide Fragments / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D011508:Chondroitin Sulfate Proteoglycans; C000604306:LUM protein, human; D000071234:Lumican; D010446:Peptide Fragments; C544543:lumcorin; D007632:Keratan Sulfate