Calcium-independent membrane damage by venom phospholipases A2.
Many snake venom phospholipase A(2)s (vPLA(2)s) present biological effects that are independent of hydrolytic activity. Here we review the evidence for the calcium-independent membrane damaging activity of vPLA(2)s, the possible relevance of this activity on their biological effects, and models for the mechanism of membrane permeabilization by these proteins.
de Oliveira
A H C
AH
Departamento de Química, FFCLRP-USP, Universidade de São Paulo, Brazil.
Aragão
E A
EA
Sá
J M
JM
Chioato
L
L
Bugs-Bortoleto
R
R
Ruller
R
R
Ferreira
T L
TL
Ward
R J
RJ
D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D002463:Cell Membrane Permeability; D006801:Humans; D016297:Mutagenesis, Site-Directed; D054467:Phospholipases A2 / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D012910:Snake Venoms / Q000201:enzymology*; D012911:Snakes
D012910:Snake Venoms; D054467:Phospholipases A2