Enantioselective synthesis of beta-trifluoromethyl-beta-lactones via NHC-catalyzed ketene-ketone cycloaddition reactions.
The highly diastereo- and enantioselective synthesis of beta-trifluoromethyl-beta-lactones bearing two contiguous stereocenters was realized by chiral N-heterocyclic carbene-catalyzed formal cycloaddition reaction of alkyl(aryl)ketenes and trifluoromethyl ketones.
Wang
Xiao-Na
XN
Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
Shao
Pan-Lin
PL
Lv
Hui
H
Ye
Song
S
D002384:Catalysis; D003500:Cyclization; D005030:Ethylenes; D007657:Ketone Bodies; D007659:Ketones / Q000737:chemistry*; D007783:Lactones / Q000138:chemical synthesis*; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
D005030:Ethylenes; D007657:Ketone Bodies; D007659:Ketones; D007783:Lactones; C030011:carbene; C008223:ketene; D008697:Methane