title: Will the real plaque vasculature please stand up? Why we need to distinguish the vasa plaquorum from the vasa vasorum.
abstract: Many studies of experimental atherosclerosis and pathologic observations of human specimens have provided evidence supporting a correlation between vascularization of the atherosclerotic plaque and its natural growth and progression toward acute failure, associated with clinical events. The growing interest in the topic is illustrated by several excellent recent reviews discussing the molecular mechanisms that might play a role in the formation of plaque vasculature and that could explain some of the observed associations with pathologic features of experimental and human atherosclerotic lesions. At the same time, these reviews also emphasize that the field is still largely in uncharted territory. Hoping to spark some new investigations, we are taking this opportunity to question some of the common assumptions and to highlight less explored mechanisms. Finally, we are proposing to adopt the term vasa plaquorum to refer to the neovasculature located within the atherosclerotic plaque to distinguish it clearly from vasa vasorum, the native, supporting vasculature of the artery. We suggest that this new nomenclature offers a potential solution to eliminate ambiguity regarding implicit, but frequently neglected, differences between these structures. We think these points are relevant for future efforts to tailor diagnostic tools and therapeutic interventions targeting plaque neovascularization for the clinical management of atherosclerosis.
authors.affiliation: Department of Surgery, Indiana University, Indianapolis, IN 46236, USA.
authors.forename: Zorina S
authors.initials: ZS
authors.lastname: Galis
authors.forename: Susan M
authors.initials: SM
authors.lastname: Lessner
mesh_terms: D018952:Antigens, CD34 / Q000032:analysis; D050197:Atherosclerosis / Q000473:pathology*; D003937:Diagnosis, Differential; D006801:Humans; D000860:Hypoxia / Q000150:complications*; D008264:Macrophages / Q000502:physiology*; D009389:Neovascularization, Pathologic / Q000175:diagnosis / Q000209:etiology / Q000473:pathology*; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000032:analysis; D009626:Terminology as Topic; D014651:Vasa Vasorum / Q000033:anatomy & histology*
chemical_list: D018952:Antigens, CD34; D019408:Platelet Endothelial Cell Adhesion Molecule-1
references.citation: J Magn Reson Imaging. 2008 Jun;27(6):1406-11
references.pmid: 18504763
references.citation: J Am Coll Cardiol. 2007 May 29;49(21):2073-80
references.pmid: 17531655
references.citation: J Am Coll Cardiol. 2003 Jun 4;41(11):1874-86
references.pmid: 12798554
references.citation: Arterioscler Thromb Vasc Biol. 2007 Aug;27(8):1706-21
references.pmid: 17541027
references.citation: FASEB J. 2006 Oct;20(12):2159-61
references.pmid: 16935942
references.citation: Circulation. 1999 Apr 6;99(13):1726-32
references.pmid: 10190883
references.citation: J Am Coll Cardiol. 2007 May 29;49(21):2093-101
references.pmid: 17531658
references.citation: Nature. 2009 Feb 12;457(7231):896-900
references.pmid: 19212410
references.citation: Arterioscler Thromb Vasc Biol. 2007 Apr;27(4):705-13
references.pmid: 17332493
references.citation: Nature. 2008 Feb 21;451(7181):904-13
references.pmid: 18288179
references.citation: Arterioscler Thromb Vasc Biol. 2005 Oct;25(10):2054-61
references.pmid: 16037567
references.citation: Arterioscler Thromb Vasc Biol. 1999 Apr;19(4):870-6
references.pmid: 10195911
references.citation: Am J Surg Pathol. 2001 Sep;25(9):1167-73
references.pmid: 11688576
references.citation: Cardiovasc Res. 2000 Jun;46(3):403-11
references.pmid: 10912451
references.citation: J Clin Invest. 1994 Dec;94(6):2493-503
references.pmid: 7989608
references.citation: Nat Med. 2003 Jun;9(6):677-84
references.pmid: 12778166
references.citation: Circulation. 2004 Nov 2;110(18):2843-50
references.pmid: 15505090
references.citation: J Am Coll Cardiol. 2008 Apr 1;51(13):1258-65
references.pmid: 18371555
references.citation: J Cell Biol. 2003 Jun 23;161(6):1163-77
references.pmid: 12810700
references.citation: J Mal Vasc. 1996;21 Suppl C:266-9
references.pmid: 8984146
references.citation: Cardiovasc Res. 1999 Feb;41(2):443-9
references.pmid: 10341843
references.citation: Am J Pathol. 2007 Aug;171(2):702-11
references.pmid: 17600129
references.citation: Nat Clin Pract Cardiovasc Med. 2008 Aug;5 Suppl 2:S18-25
references.pmid: 18641602
references.citation: J Vasc Surg. 1999 Aug;30(2):261-8
references.pmid: 10436445
references.citation: Circ Res. 2006 Feb 3;98(2):159-62
references.pmid: 16456105
references.citation: J Appl Physiol (1985). 2009 Feb;106(2):711-28
references.pmid: 19023021
references.citation: Hum Pathol. 1995 Apr;26(4):450-6
references.pmid: 7535741
references.citation: Arterioscler Thromb Vasc Biol. 1997 Nov;17(11):2333-40
references.pmid: 9409199
references.citation: J Interv Cardiol. 2002 Dec;15(6):439-46
references.pmid: 12476646
references.citation: Trends Pharmacol Sci. 2008 Jan;29(1):12-5
references.pmid: 18068232
references.citation: Am Heart J. 1998 Dec;136(6):1096-105
references.pmid: 9842026
references.citation: Am J Pathol. 1993 Jul;143(1):164-72
references.pmid: 7686341
references.citation: Am Heart J. 1998 Jan;135(1):10-4
references.pmid: 9453515
references.citation: Eur J Clin Invest. 1991 Jun;21(3):355-9
references.pmid: 1909639
references.citation: N Engl J Med. 2003 Dec 11;349(24):2316-25
references.pmid: 14668457
references.citation: FASEB J. 2006 Jul;20(9):1495-7
references.pmid: 16754748
references.citation: Circulation. 2004 Oct 5;110(14):2032-8
references.pmid: 15451780
references.citation: Circulation. 2004 Feb 3;109(4):520-5
references.pmid: 14744973
references.citation: J Clin Invest. 1998 Apr 15;101(8):1551-6
references.pmid: 9541483
references.citation: Cancer Res. 2006 Apr 15;66(8):3967-70
references.pmid: 16618712
references.citation: Circ Res. 2004 Feb 6;94(2):262-8
references.pmid: 14670843
references.citation: J Cell Biol. 2005 May 23;169(4):681-91
references.pmid: 15911882
references.citation: Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2426-31
references.pmid: 12606720
references.citation: Am J Pathol. 1999 Sep;155(3):739-52
references.pmid: 10487832
references.citation: Am J Pathol. 2000 Feb;156(2):361-81
references.pmid: 10666364
references.citation: J Natl Cancer Inst. 2002 Oct 2;94(19):1484-93
references.pmid: 12359857
references.citation: Circ Res. 1967 Apr;20(4):409-21
references.pmid: 4960913
references.citation: Dev Cell. 2008 Aug;15(2):261-71
references.pmid: 18694565
references.citation: Circulation. 2003 Nov 4;108(18):2270-4
references.pmid: 14557370
references.citation: Arch Pathol Lab Med. 1985 Jul;109(7):659-62
references.pmid: 2409950
references.citation: Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4736-41
references.pmid: 12682294
references.citation: Anat Rec A Discov Mol Cell Evol Biol. 2003 Jun;272(2):526-37
references.pmid: 12740947
references.citation: Arterioscler Thromb Vasc Biol. 2006 Feb;26(2):347-52
references.pmid: 16293797
references.citation: Neth Heart J. 2007;15(2):77-80
references.pmid: 18604278
references.citation: Am Heart J. 2003 May;145(5):813-20
references.pmid: 12766737
references.citation: Proc Natl Acad Sci U S A. 1995 Jan 17;92(2):402-6
references.pmid: 7831299
references.citation: Arterioscler Thromb Vasc Biol. 2006 Sep;26(9):1948-57
references.pmid: 16794218
references.citation: Pediatr Res. 2006 Apr;59(4 Pt 2):26R-32R
references.pmid: 16549545
references.citation: Magn Reson Med. 2008 Mar;59(3):507-14
references.pmid: 18306402
references.citation: J Natl Cancer Inst. 2004 Oct 6;96(19):1473-7
references.pmid: 15467037
references.citation: Circ Res. 2007 Jul 20;101(2):125-36
references.pmid: 17641236
references.citation: Am J Pathol. 2002 Jun;160(6):2145-55
references.pmid: 12057918
references.citation: Eur J Echocardiogr. 2009 Mar;10(2):260-4
references.pmid: 18757860
references.citation: J Vasc Surg. 1987 Oct;6(4):341-9
references.pmid: 2443731
references.citation: J Clin Oncol. 2002 Nov 1;20(21):4368-80
references.pmid: 12409337
references.citation: J Hematother Stem Cell Res. 2002 Apr;11(2):179-94
references.pmid: 11983092
references.citation: Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):14082-7
references.pmid: 18779589
references.citation: Circulation. 2003 Mar 4;107(8):1164-9
references.pmid: 12615796
references.citation: Cardiovasc Res. 2007 Sep 1;75(4):649-58
references.pmid: 17631284
references.citation: Novartis Found Symp. 2007;283:194-201; discussion 201-6, 238-41
references.pmid: 18300423
references.citation: Biochem Soc Trans. 2004 Jun;32(Pt3):397-402
references.pmid: 15157146