[Immunosuppression in hand transplantation: state of the art and future perspectives].
Avoidance or minimization of maintenance immunosuppression represents the key step for promoting wider applicability of reconstructive transplantation. Understanding the mechanisms of composite tissue allograft rejection is of essence in working towards this goal. We herein review the current knowledge on acute rejection in reconstructive transplantation and discuss findings in the light of novel immunosuppressive and immunomodulatory strategies.
Sucher
Robert
R
Medizinische Universität Insbruck, Abteilung für Allgemein-, Transplantations- und Thoraxchirurgie, Innsbruck, Austria. robert.sucher@i-med.ac.at
Hautz
T
T
Brandacher
G
G
Lee
W P Andrew
WP
Margreiter
R
R
Schneeberger
S
S
D000328:Adult; D000528:Alternaria; D000935:Antifungal Agents / Q000009:adverse effects / Q000627:therapeutic use; D000998:Antiviral Agents / Q000009:adverse effects / Q000627:therapeutic use; D003586:Cytomegalovirus Infections / Q000188:drug therapy; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005500:Follow-Up Studies; D005544:Forecasting; D006084:Graft Rejection / Q000188:drug therapy*; D063987:Hand Transplantation; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008866:Microsurgery / Q000379:methods*; D008875:Middle Aged; D009181:Mycoses / Q000188:drug therapy; D009894:Opportunistic Infections / Q000188:drug therapy; D012008:Recurrence; D013524:Surgical Flaps; D055815:Young Adult
D000935:Antifungal Agents; D000998:Antiviral Agents; D007166:Immunosuppressive Agents