title: Crassocolides G-M, cembranoids from the Formosan soft coral Sarcophyton crassocaule.
abstract: Seven new polyoxygenated cembranoids possessing an alpha-methylene-gamma-lactone group, crassocolides G-M (1-7, resp.), have been isolated from the AcOEt extract of the Formosan soft coral Sarcophyton crassocaule. The structures of compounds 1-7 were established by detailed spectroscopic analyses, including 2D-NMR spectroscopy ((1)H,(1)H-COSY, HMQC, HMBC, and NOESY), while the absolute configuration of 1 was determined using a modified reaction of Mosher's method. The cytotoxicity of compounds 1-7 against a limited panel of cancer cell lines was also determined.
authors.affiliation: Department of Chemical and Materials Engineering, Cheng Shiu University, Kaohsiung, Taiwan.
authors.forename: Ho-Cheng
authors.initials: HC
authors.lastname: Huang
authors.forename: Chih-Hua
authors.initials: CH
authors.lastname: Chao
authors.forename: Yao-Haur
authors.initials: YH
authors.lastname: Kuo
authors.forename: Jyh-Horng
authors.initials: JH
authors.lastname: Sheu
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000494:pharmacology; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: D000970:Antineoplastic Agents; D019086:Bridged Bicyclo Compounds, Heterocyclic; D007783:Lactones