title: A Golgi-on-a-chip for glycan synthesis.
abstract: One of the primary functions of the Golgi apparatus is the assembly of glycans on macromolecules destined for secretion or the plasma membrane. A recent study describes the first step toward an artificial Golgi, based on a microfluidic chip and magnetic nanoparticles.
authors.affiliation: Department of Cellular and Molecular Medicine, Glycobiology Research and Training Center, University of California-San Diego, La Jolla, California, USA.
authors.forename: Ding
authors.initials: D
authors.lastname: Xu
authors.forename: Jeffrey D
authors.initials: JD
authors.lastname: Esko
mesh_terms: D001665:Binding Sites; D006031:Glycosylation; D006056:Golgi Apparatus / Q000201:enzymology / Q000378:metabolism*; D006497:Heparan Sulfate / Q000096:biosynthesis / Q000737:chemistry; D008024:Ligands; D046210:Microfluidic Analytical Techniques; D008954:Models, Biological; D011134:Polysaccharides / Q000096:biosynthesis* / Q000737:chemistry
chemical_list: D006497:Heparan Sulfate; D008024:Ligands; D011134:Polysaccharides
references.citation: Proc Natl Acad Sci U S A. 2008 Mar 25;105(12):4751-6
references.pmid: 18337501
references.citation: J Am Chem Soc. 2009 Aug 12;131(31):11041-8
references.pmid: 19591465
references.citation: Anal Chem. 2006 Nov 15;78(22):7877-85
references.pmid: 17105183
references.citation: Chem Biol. 2007 Sep;14(9):986-93
references.pmid: 17884631
references.citation: Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):12984-9
references.pmid: 11687650
references.citation: Biochemistry. 1985 Nov 5;24(23):6723-9
references.pmid: 4084555
references.citation: J Clin Invest. 2001 Jul;108(2):169-73
references.pmid: 11457867
references.citation: Annu Rev Biochem. 2002;71:435-71
references.pmid: 12045103
references.citation: Proc Natl Acad Sci U S A. 1980 Nov;77(11):6551-5
references.pmid: 6935668
references.citation: Nature. 2007 Apr 26;446(7139):1030-7
references.pmid: 17460664