title: Antidiarrhoeal activity of carbazole alkaloids from Murraya koenigii Spreng (Rutaceae) seeds.
abstract: The bioassay guided fractionation of the n-hexane extract of the seeds of Murraya koenigii Spreng (Rutaceae) resulted in the isolation of three bioactive carbazole alkaloids, kurryam (I), koenimbine (II) and koenine (III). The structures of the compounds were confirmed from their (1)H-, (13)C-, and 2D-NMR spectral data. Of the three compounds (I) and (II) exhibited significant inhibitory activity against castor oil-induced diarrhoea and PGE(2)-induced enteropooling in rats. The compounds also produced a significant reduction in gastrointestinal motility in the charcoal meal test in Wistar rats.
authors.affiliation: Department of Chemistry, National Research Institute of Ayurveda for Drug Development, Bidhannagar, Kolkata - 700091, India.
authors.forename: Suvra
authors.initials: S
authors.lastname: Mandal
authors.forename: Anupam
authors.initials: A
authors.lastname: Nayak
authors.forename: Manoj
authors.initials: M
authors.lastname: Kar
authors.forename: Samir K
authors.initials: SK
authors.lastname: Banerjee
authors.forename: Ashes
authors.initials: A
authors.lastname: Das
authors.forename: S N
authors.initials: SN
authors.lastname: Upadhyay
authors.forename: R K
authors.initials: RK
authors.lastname: Singh
authors.forename: Avijit
authors.initials: A
authors.lastname: Banerji
authors.forename: Julie
authors.initials: J
authors.lastname: Banerji
mesh_terms: D000818:Animals; D000930:Antidiarrheals / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D002368:Castor Oil; D002400:Cathartics; D003967:Diarrhea / Q000139:chemically induced / Q000188:drug therapy*; D015232:Dinoprostone; D004157:Diphenoxylate; D004353:Drug Evaluation, Preclinical; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects; D026121:Indole Alkaloids / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D015394:Molecular Structure; D010120:Oxytocics; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D027821:Rutaceae / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry
chemical_list: D000930:Antidiarrheals; D002400:Cathartics; D026121:Indole Alkaloids; D010120:Oxytocics; D010936:Plant Extracts; D004157:Diphenoxylate; D002368:Castor Oil; D015232:Dinoprostone