title: Methylphenidate for giggle incontinence.
abstract: OBJECTIVE
  Giggle incontinence or enuresis risoria is a socially embarrassing problem characterized by involuntary and complete bladder emptying in response to laughter. To our knowledge the cause of giggle incontinence is unknown, although a functional relationship to cataplexy was suggested. We retrospectively examined the effectiveness of methylphenidate for giggle incontinence in children.
  
  
  METHODS
  We retrospectively reviewed the charts of patients referred to a pediatric specialty voiding center between 2004 and 2008 for wetting associated with laughter. Patients who met giggle incontinence criteria with no associated urgency or urge incontinence were offered a trial of methylphenidate. Wetting frequency was assessed before and during methylphenidate treatment.
  
  
  RESULTS
  A total of 20 patients with a mean age of 12.4 years (range 7.5 to 15.5) met giggle incontinence criteria with no other wetting reported. Incontinence frequency was daily to less than once weekly. After a timed voiding trial 15 of 20 patients (75%) elected a methylphenidate trial, of whom 12 (80%) reported prompt and complete cessation of wetting. Treatment duration was 2 months to greater than 3 years.
  
  
  CONCLUSIONS
  Giggle incontinence with no other urinary symptoms is a rare form of incontinence. Methylphenidate was a viable option for giggle incontinence but it was not accepted by all families.
authors.affiliation: Division of Urology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.
authors.forename: Amanda K
authors.initials: AK
authors.lastname: Berry
authors.forename: Stephen
authors.initials: S
authors.lastname: Zderic
authors.forename: Michael
authors.initials: M
authors.lastname: Carr
mesh_terms: D000293:Adolescent; D000697:Central Nervous System Stimulants / Q000627:therapeutic use*; D002648:Child; D005260:Female; D006801:Humans; D007845:Laughter; D008297:Male; D008774:Methylphenidate / Q000627:therapeutic use*; D012189:Retrospective Studies; D014549:Urinary Incontinence / Q000188:drug therapy*
chemical_list: D000697:Central Nervous System Stimulants; D008774:Methylphenidate