title: Interictal arterial spin-labeling MRI perfusion in intractable epilepsy.
abstract: BACKGROUND
  Magnetic resonance imaging (MRI) is required for the investigation of surgically intractable epilepsy. In addition to the standard MRI techniques, perfusion sequences can be added to improve visualization of underlying pathological changes. Arterial spin-labeling (ASL) MRI perfusion does not require contrast administration and, for this reason, may have advantages in these patients.
  
  
  METHODS
  We report here on 16 patients with epilepsy who underwent MRI of the brain with ASL and positron emission tomography (PET).
  
  
  RESULTS
  Despite a slightly reduced resolution with ASL, we found a correlation between ASL, PET and electrophysiological data, with hypoperfusion on ASL that corresponded with hypoperfusion on interictal PET.
  
  
  CONCLUSIONS
  Given the correlation between ASL and PET and electrophysiology, perfusion with ASL could become part of the standard work-up in patients with epilepsy.
authors.affiliation: Department of Neuroradiology, Geneva University Hospital, Switzerland.
authors.forename: N
authors.initials: N
authors.lastname: Pendse
authors.forename: M
authors.initials: M
authors.lastname: Wissmeyer
authors.forename: S
authors.initials: S
authors.lastname: Altrichter
authors.forename: M
authors.initials: M
authors.lastname: Vargas
authors.forename: J
authors.initials: J
authors.lastname: Delavelle
authors.forename: M
authors.initials: M
authors.lastname: Viallon
authors.forename: A
authors.initials: A
authors.lastname: Federspiel
authors.forename: M
authors.initials: M
authors.lastname: Seeck
authors.forename: K
authors.initials: K
authors.lastname: Schaller
authors.forename: K O
authors.initials: KO
authors.lastname: Lövblad
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000473:pathology*; D002648:Child; D004827:Epilepsy / Q000175:diagnosis*; D005260:Female; D006801:Humans; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013113:Spin Labels; D055815:Young Adult
chemical_list: D013113:Spin Labels