title: Impact of capsule endoscopy findings on patient outcomes.
abstract: OBJECTIVE
  There is limited data on the impact of capsule endoscopy (CE) findings on patient outcomes. The aim of our study is to evaluate the impact of CE findings on further diagnostic work-up, treatment, and symptom resolution.
  
  
  METHODS
  A retrospective chart review of patients who underwent CE at a single tertiary care center over a 3-year period was performed. CE findings were classified as positive, suspicious, or negative. Therapeutic interventions were medical, endoscopic, surgical, other, or none. Symptoms were considered resolved when the patient had cessation of symptoms for at least 6 months post-CE.
  
  
  RESULTS
  A total of 193 patients were studied. The overall diagnostic yield of CE was 37%. There were 97 (50%) patients who had further diagnostic testing following CE; (40 with positive, 22 with suspicious, 35 with negative CE findings). There were 76% patients who received treatment post-CE (59% with positive, 43% with suspicious, 49% with negative CE findings). Overall symptom resolution was seen in 71% of patients (59% with positive, 68% with suspicious, 70% with negative CE findings). There was no statistically significant difference in diagnostic work-up, treatment, and symptom resolution between patients with positive, suspicious, and negative findings. Patients with obscure overt GI bleeding were less likely to have further diagnostic work-up (P = 0.001), and had the highest rate of symptom resolution as compared to other indications (P < 0.001).
  
  
  CONCLUSIONS
  There is no significant difference in outcomes amongst patients with positive, suspicious, and negative CE findings. Patients with obscure overt GI bleeding had more favorable outcomes as compared to other indications.
authors.affiliation: Department of Medicine, Hospital of the University of Pennsylvania, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
authors.forename: Stephen
authors.initials: S
authors.lastname: Kim
authors.forename: Prashant S
authors.initials: PS
authors.lastname: Kedia
authors.forename: David L
authors.initials: DL
authors.lastname: Jaffe
authors.forename: Nuzhat A
authors.initials: NA
authors.lastname: Ahmad
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D053704:Capsule Endoscopy; D005260:Female; D006801:Humans; D007410:Intestinal Diseases / Q000175:diagnosis* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult
references.citation: Am J Gastroenterol. 2008 Dec;103(12):3022-8
references.pmid: 19086954
references.citation: Am J Gastroenterol. 2006 Jan;101(1):52-7
references.pmid: 16405533
references.citation: Gut. 2003 Jun;52 Suppl 4:iv48-50
references.pmid: 12746269
references.citation: Endoscopy. 2003 Dec;35(12):1009-14
references.pmid: 14648412
references.citation: Dig Dis Sci. 2008 Aug;53(8):2140-3
references.pmid: 18270840
references.citation: Endoscopy. 2002 Sep;34(9):685-9
references.pmid: 12195324
references.citation: Gastroenterology. 2002 Oct;123(4):999-1005
references.pmid: 12360460
references.citation: Gastrointest Endosc. 2005 Jun;61(7):826-32
references.pmid: 15933683
references.citation: Radiology. 2004 Jan;230(1):260-5
references.pmid: 14617764
references.citation: Endoscopy. 2004 Dec;36(12):1067-73
references.pmid: 15578296
references.citation: Gastrointest Endosc. 2008 Jul;68(1):98-104
references.pmid: 18291382
references.citation: Gastrointest Endosc Clin N Am. 2004 Jan;14(1):51-60
references.pmid: 15062380