title: Combined clozapine-lithium treatment for schizophrenia and schizoaffective disorder.
abstract: Three adolescent and two adult patients suffering from chronic excited psychoses (either schizophrenia or schizoaffective disorder) resistant to traditional neuroleptics and clozapine were treated with combined clozapine-lithium. Improvement was assessed with the Positive and Negative Symptoms Scale, the Brief Psychiatric Rating Scale and the Clinical Global Impressions, administered before and during combined clozapine-lithium treatment. All patients demonstrated a significant improvement with this combination. There was no occurrence of agranulocytosis, neuroleptic malignant syndrome or other clinically significant adverse effects.
authors.affiliation: Abarbanel Mental Health Center, 15 Keren Kayemet St, Bat-Yam, 59100, Israel, affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: M
authors.initials: M
authors.lastname: Moldavsky
authors.forename: D
authors.initials: D
authors.lastname: Stein
authors.forename: R
authors.initials: R
authors.lastname: Benatov
authors.forename: P
authors.initials: P
authors.lastname: Sirota
authors.forename: A
authors.initials: A
authors.lastname: Elizur
authors.forename: Y
authors.initials: Y
authors.lastname: Matzner
authors.forename: A
authors.initials: A
authors.lastname: Weizman