title: On-chip technologies for multidimensional separations.
abstract: We review microfluidic devices designed for multidimensional sample analysis, with a primer on relevant theory, an emphasis on protein analysis, and an eye towards future improvements and challenges to the field. Image shows results of an on-chip IEF-CE separation of a protein mixture; unpublished surface plot data from A. E. Herr.
authors.affiliation: Department of Bioengineering, University of California, Berkeley, 308B Stanley Hall, MC # 1762 Berkeley, CA 94720-1762, USA.
authors.forename: Samuel
authors.initials: S
authors.lastname: Tia
authors.forename: Amy E
authors.initials: AE
authors.lastname: Herr
mesh_terms: D002851:Chromatography, High Pressure Liquid; D010316:Particle Size; D011506:Proteins / Q000302:isolation & purification*
chemical_list: D011506:Proteins