title: From IL-10 to IL-12: how pathogens and their products stimulate APCs to induce T(H)1 development.
abstract: The authors recount their discovery of how pathogen-induced interleukin 12 production leads to T(H)1 T cell polarization. Simultaneously they discovered the suppressive cytokine interleukin 10 inhibits antigen-presenting cells, thus regulating development of T(H)1 cells.
authors.affiliation: Division of Immunoregulation, The Medical Research Council National Institute for Medical Research, London, UK. aogarra@nimr.mrc.ac.uk
authors.forename: Anne
authors.initials: A
authors.lastname: O'Garra
authors.forename: Kenneth M
authors.initials: KM
authors.lastname: Murphy
mesh_terms: D000818:Animals; D000938:Antigen-Presenting Cells / Q000502:physiology*; D002454:Cell Differentiation; D016764:Cell Polarity; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis; D016753:Interleukin-10 / Q000502:physiology*; D018664:Interleukin-12 / Q000502:physiology*; D008264:Macrophages / Q000502:physiology; D018417:Th1 Cells / Q000502:physiology*; D018418:Th2 Cells / Q000502:physiology
chemical_list: D016753:Interleukin-10; D018664:Interleukin-12; D007371:Interferon-gamma
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