title: WNT5a in tongue and fungiform Papilla development.
abstract: Fungiform papillae are complex taste organs that develop in a pattern on anterior tongue in rodent embryos. Several intrinsic secreted molecules are important for papilla development and patterning, including sonic hedgehog, bone morphogenetic proteins, Noggin, epidermal growth factor, and WNTs. Recent data about roles of WNTs in regulation of tongue and fungiform papilla development lead to new insights about the importance of tissue and timing contexts when studying the effects of morphogenetic proteins. WNT/beta-catenin signaling is required for formation of fungiform papillae, but not for determining tongue size and shape. In contrast, WNT5a apparently is important for tongue outgrowth, but not papilla development. Preliminary data from WNT5a mutant mice separate genetic programs for papilla number from those for tongue shape and size.
authors.affiliation: School of Dentistry, University of Michigan, Ann Arbor, Michigan 48109-1078, USA.
authors.forename: Hong-Xiang
authors.initials: HX
authors.lastname: Liu
authors.forename: Ann M Staubach
authors.initials: AM
authors.lastname: Grosse
authors.forename: Katherine D
authors.initials: KD
authors.lastname: Walton
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Saims
authors.forename: Deborah L
authors.initials: DL
authors.lastname: Gumucio
authors.forename: Charlotte M
authors.initials: CM
authors.lastname: Mistretta
mesh_terms: D000818:Animals; D051379:Mice; D008855:Microscopy, Electron, Scanning; D015398:Signal Transduction; D013650:Taste Buds / Q000254:growth & development*; D051153:Wnt Proteins / Q000378:metabolism / Q000502:physiology*; D000071818:Wnt-5a Protein; D051176:beta Catenin / Q000378:metabolism
chemical_list: D051153:Wnt Proteins; D000071818:Wnt-5a Protein; C102068:Wnt10b protein, mouse; C438615:Wnt5a protein, mouse; D051176:beta Catenin
references.citation: J Comp Neurol. 1997 Jan 20;377(3):324-40
references.pmid: 8989649
references.citation: Arch Histol Cytol. 2006 Dec;69(4):199-208
references.pmid: 17287575
references.citation: Development. 1999 Mar;126(6):1211-23
references.pmid: 10021340
references.citation: Dev Dyn. 2008 Sep;237(9):2378-93
references.pmid: 18729215
references.citation: Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2253-8
references.pmid: 17284610
references.citation: Dev Biol. 2004 Dec 15;276(2):280-300
references.pmid: 15581865
references.citation: Ann N Y Acad Sci. 1998 Nov 30;855:1-13
references.pmid: 9929582
references.citation: Development. 2008 Apr;135(7):1365-76
references.pmid: 18305003
references.citation: Science. 2008 Apr 18;320(5874):365-9
references.pmid: 18420933
references.citation: Genes Dev. 2006 Oct 1;20(19):2654-9
references.pmid: 17015430
references.citation: Dev Biol. 2006 Sep 1;297(1):198-213
references.pmid: 16828469
references.citation: Development. 2007 Nov;134(21):3929-39
references.pmid: 17898001
references.citation: Dev Biol. 2003 Feb 1;254(1):1-18
references.pmid: 12606278
references.citation: Dev Biol. 2003 Mar 15;255(2):263-77
references.pmid: 12648489
references.citation: Nat Genet. 2007 Jan;39(1):106-12
references.pmid: 17128274
references.citation: Cell Tissue Res. 2001 Jan;303(1):35-45
references.pmid: 11236003