Synthesis of functionalized isoquinolines via sequential cyclization/cross-coupling reactions.
CuX(2)-mediated cyclization of 2-alkynylbenzaldehyde O-methyl oximes in N,N-dimethylacetamide (DMA) gave rise to 4-chloroisoquinolines in good yield, which underwent the palladium-catalyzed cross-coupling reactions of arylboronic acids subsequently to afford the functionalized isoquinolines.
Yu
Xingxin
X
Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China.
Wu
Jie
J
D002384:Catalysis; D003300:Copper / Q000737:chemistry; D003500:Cyclization; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010165:Palladium / Q000737:chemistry
D007546:Isoquinolines; D010165:Palladium; D003300:Copper