title: Coumarins from Angelica lucida L.--antibacterial activities.
abstract: The first phytochemical investigation of the fruits of Angelica lucida has led to the isolation and characterization of five known coumarins (imperatorin, isoimperatorin, heraclenol, oxypeucedanin hydrate and heraclenin). All isolated compounds were identified by means of spectral and literature data. The extracts and the isolated constituents from A. lucida have been also evaluated for their antimicrobial activity against six Gram positive and negative bacteria, two oral pathogens and three human pathogenic fungi, exhibiting an interesting antimicrobial profile.
authors.affiliation: Department of Pharmacognosy with Medicinal Plant Laboratory, Skubiszewski Medicinal University of Lublin, 1 Chodzki str., 20-093, Poland.
authors.forename: Jaroslaw
authors.initials: J
authors.lastname: Widelski
authors.forename: Milena
authors.initials: M
authors.lastname: Popova
authors.forename: Konstantia
authors.initials: K
authors.lastname: Graikou
authors.forename: Kazimierz
authors.initials: K
authors.lastname: Glowniak
authors.forename: Ioanna
authors.initials: I
authors.lastname: Chinou
mesh_terms: D029969:Angelica / Q000737:chemistry*; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D001578:Benzopyrans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D003374:Coumarins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D005638:Fruit / Q000737:chemistry; D005658:Fungi / Q000187:drug effects; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D011564:Furocoumarins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000890:Anti-Infective Agents; D001578:Benzopyrans; D003374:Coumarins; D005663:Furans; D011564:Furocoumarins; D010936:Plant Extracts; C055542:isoimperatorin; C087805:heraclenol; C047845:heraclenin; C031534:imperatorin; C031535:oxypeucadanin
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