title: [Effects of (-)-epigallocatechin-3-gallate on interleukin-1beta expression in mouse wound healing].
abstract: (-)-Epigallocatechin-3-gallate (EGCG), a main constituent of green tea polyphenols, plays important roles in antioxidative, anti-senescence, anti-tumor, anti-inflammation and bacterail action. In this study, effects of EGCG on the expression of IL-1beta gene and the IL-1beta level at wound sites during cutaneous wound healing were investigated with histological stain, ELISA and RT-PCR technique. The results show that EGCG (50 mg/L) inhibited the expression of IL-1beta gene and reduced the IL-beta level at wound sites at 72 h after cutaneous wound, but not change the expression of IL-1beta gene and the IL-1beta level at early stage (< or =24 h).
authors.affiliation: College of Life Sciences, Henan Normal University, Henan Xinxiang 453007.
authors.forename: Yu Jia
authors.initials: YJ
authors.lastname: Shen
authors.forename: Wei Guo
authors.initials: WG
authors.lastname: Li
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.forename: Bin
authors.initials: B
authors.lastname: Li
authors.forename: Hong Xu
authors.initials: HX
authors.lastname: Yuan
authors.forename: Jiang Jiang
authors.initials: JJ
authors.lastname: Zhang
mesh_terms: D000818:Animals; D002392:Catechin / Q000031:analogs & derivatives* / Q000494:pharmacology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects*; D053583:Interleukin-1beta / Q000235:genetics* / Q000378:metabolism; D008297:Male; D051379:Mice; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects* / Q000235:genetics*
chemical_list: D053583:Interleukin-1beta; D002392:Catechin; C045651:epigallocatechin gallate