title: Recurrent hemoptysis with Penicillium marneffei and Stenotrophomonas maltophilia in Job's syndrome.
abstract: Pulmonary infection caused by the opportunistic organisms Penicillium marneffei and Stenotrophomonas maltophilia in patients with Job's syndrome is rare and not well documented. The case of a 30-year-old man with Job's syndrome who developed recurrent pneumonia and lung abscesses caused by P. marneffei and S. maltophilia, complicated by massive hemoptysis, is described. Bronchial artery embolization was successful in controlling the hemoptysis; however, the infection proved fatal despite appropriate antimicrobial therapy. A brief review of the literature on Job's syndrome and its associated infective pulmonary manifestations is also presented.
authors.affiliation: Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.
authors.forename: Bosco H M
authors.initials: BH
authors.lastname: Ma
authors.forename: Calvin S H
authors.initials: CS
authors.lastname: Ng
authors.forename: Rebecca  K Y
authors.initials: R
authors.lastname: Lam
authors.forename: Song
authors.initials: S
authors.lastname: Wan
authors.forename: Innes Y P
authors.initials: IY
authors.lastname: Wan
authors.forename: Tak Wai
authors.initials: TW
authors.lastname: Lee
authors.forename: Anthony P C
authors.initials: AP
authors.lastname: Yim
mesh_terms: D000328:Adult; D016905:Gram-Negative Bacterial Infections / Q000150:complications*; D006469:Hemoptysis / Q000382:microbiology*; D006801:Humans; D007589:Job Syndrome / Q000150:complications / Q000382:microbiology*; D008172:Lung Diseases, Fungal / Q000150:complications*; D008297:Male; D010407:Penicillium / Q000302:isolation & purification*; D020615:Stenotrophomonas maltophilia / Q000302:isolation & purification*
references.citation: Thorax. 2004 Nov;59(11):955-9
references.pmid: 15516471
references.citation: Ann Thorac Surg. 1992 Dec;54(6):1206-8
references.pmid: 1449312
references.citation: Ann Thorac Surg. 1990 Dec;50(6):992-4
references.pmid: 2241394
references.citation: Clin Immunol Immunopathol. 1980 Dec;17(4):483-91
references.pmid: 6108173
references.citation: Ann Thorac Surg. 1995 Mar;59(3):759-61
references.pmid: 7887732
references.citation: Clin Rev Allergy Immunol. 2001 Feb;20(1):139-54
references.pmid: 11269224
references.citation: Lancet. 1966 May 7;1(7445):1013-5
references.pmid: 4161105
references.citation: Bone Marrow Transplant. 2005 Apr;35(8):831-3
references.pmid: 15765113
references.citation: Scand Cardiovasc J. 1997;31(3):177-9
references.pmid: 9264169
references.citation: N Engl J Med. 1999 Mar 4;340(9):692-702
references.pmid: 10053178
references.citation: Pediatr Radiol. 1994;24(8):592-3
references.pmid: 7724285
references.citation: Australas Radiol. 2000 Aug;44(3):328-30
references.pmid: 10974730
references.citation: J Thorac Imaging. 2004 Jan;19(1):48-51
references.pmid: 14712133