title: Colchicine is effective for short-term treatment of slow transit constipation: a double-blind placebo-controlled clinical trial.
abstract: OBJECTIVE
  Although colchicine has been tested in clinical trials for treatment of constipation, the index groups in those trials were composed of special patient groups with developmental neuromuscular defects or failed surgical management. The aim of this study is to investigate the efficacy of colchicine in patients with refractory slow transit constipation.
  
  
  METHODS
  Sixty patients with chief complaint of chronic constipation due to slow transit consented to be included in the double-blind placebo-controlled clinical trial. These patients were randomly divided into two groups (each containing 30 patients) to receive either colchicine, 1 mg QD, (group A) or placebo (group B) for 2 months. At the end of the study, Knowles-Eccersly-Scot symptom (KESS, a valid technique to assist in the diagnosis and evaluation of symptoms in constipation) scores were compared between the case and control groups.
  
  
  RESULTS
  The mean KESS score measured at the end of 2 months was 11.67 +/- 3.91 for colchicine and 18.66 +/- 3.72 for placebo group (p = 0.0001).
  
  
  CONCLUSIONS
  This trial shows that low-dose colchicine is effective in treatment of slow transit constipation.
authors.affiliation: Gastroenterohepatology Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, PO Box 71345-1744, Shiraz, Iran.
authors.forename: Seyed Alireza
authors.initials: SA
authors.lastname: Taghavi
authors.forename: Sanaz
authors.initials: S
authors.lastname: Shabani
authors.forename: Asie
authors.initials: A
authors.lastname: Mehramiri
authors.forename: Ahad
authors.initials: A
authors.lastname: Eshraghian
authors.forename: Seyed Mohammad Hasan
authors.initials: SM
authors.lastname: Kazemi
authors.forename: Maryam
authors.initials: M
authors.lastname: Moeini
authors.forename: Seyed Mohammad Kazem
authors.initials: SM
authors.lastname: Hosseini-Asl
authors.forename: Mehdi
authors.initials: M
authors.lastname: Saberifiroozi
authors.forename: Mahvash
authors.initials: M
authors.lastname: Alizade-Naeeni
authors.forename: Amir Ahmad
authors.initials: AA
authors.lastname: Mostaghni
mesh_terms: D000328:Adult; D003078:Colchicine / Q000627:therapeutic use*; D003248:Constipation / Q000188:drug therapy* / Q000503:physiopathology*; D003710:Demography; D004311:Double-Blind Method; D005260:Female; D005772:Gastrointestinal Transit / Q000502:physiology*; D006801:Humans; D008297:Male; D010919:Placebos; D013997:Time Factors; D050257:Tubulin Modulators / Q000627:therapeutic use*
chemical_list: D010919:Placebos; D050257:Tubulin Modulators; D003078:Colchicine
references.citation: Am J Gastroenterol. 1996 Jan;91(1):26-32
references.pmid: 8561138
references.citation: Ann Surg. 1993 Dec;218(6):761-8
references.pmid: 8257226
references.citation: J Clin Gastroenterol. 2001 Jul;33(1):81-4
references.pmid: 11418801
references.citation: Aliment Pharmacol Ther. 1997 Dec;11(6):1059-66
references.pmid: 9663830
references.citation: Korean J Intern Med. 1996 Jun;11(2):151-6
references.pmid: 8854652
references.citation: Am J Gastroenterol. 2003 May;98(5):1112-6
references.pmid: 12809836
references.citation: Aliment Pharmacol Ther. 2006 Jun 1;23(11):1655-65
references.pmid: 16696817
references.citation: Dis Colon Rectum. 2000 Oct;43(10):1419-26
references.pmid: 11052520
references.citation: Pediatrics. 2006 Sep;118(3):e641-8
references.pmid: 16950955
references.citation: Clin Gastroenterol Hepatol. 2009 May;7(5):537-44
references.pmid: 19418602
references.citation: Int J Colorectal Dis. 2004 Sep;19(5):467-73
references.pmid: 15045515
references.citation: Ann Surg. 1991 Oct;214(4):403-11; discussion 411-3
references.pmid: 1953096
references.citation: BMJ. 2009 Mar 20;338:b831
references.pmid: 19304766
references.citation: J Am Board Fam Pract. 1998 Sep-Oct;11(5):341-6
references.pmid: 9796763
references.citation: Curr Treat Options Gastroenterol. 2002 Aug;5(4):279-283
references.pmid: 12095475
references.citation: Dig Dis Sci. 1982 Aug;27(8):723-7
references.pmid: 6284460
references.citation: Gut. 2002 Oct;51(4):496-501
references.pmid: 12235070
references.citation: Dig Dis Sci. 1995 Nov;40(11):2450-5
references.pmid: 7587830
references.citation: Dis Colon Rectum. 1991 Oct;34(10):851-6
references.pmid: 1914716
references.citation: N Engl J Med. 2004 Sep 23;351(13):1361-4; discussion 1361-4
references.pmid: 15385670
references.citation: Clin Gastroenterol Hepatol. 2004 Sep;2(9):796-805
references.pmid: 15354280
references.citation: N Engl J Med. 1987 Jun 18;316(25):1562-8
references.pmid: 3035372
references.citation: Am J Gastroenterol. 2005 Apr;100(4):936-71
references.pmid: 15784043
references.citation: Eur J Pharmacol. 1980 Oct 17;67(2-3):235-9
references.pmid: 6257530
references.citation: Gastroenterology. 2002 Nov;123(5):1459-67
references.pmid: 12404220
references.citation: J Clin Gastroenterol. 2004 Sep;38(8):680-5
references.pmid: 15319652
references.citation: Neurogastroenterol Motil. 2005 Oct;17(5):697-704
references.pmid: 16185308
references.citation: N Engl J Med. 2003 Oct 2;349(14):1360-8
references.pmid: 14523145
references.citation: Dig Dis Sci. 1993 Nov;38(11):2017-21
references.pmid: 8223075
references.citation: J Pharmacol Exp Ther. 2001 Dec;299(3):1007-12
references.pmid: 11714889
references.citation: Curr Opin Pharmacol. 2008 Dec;8(6):724-8
references.pmid: 18687411
references.citation: Gastroenterol Clin North Am. 2001 Mar;30(1):97-114
references.pmid: 11394039
references.citation: Am J Physiol. 1997 Nov;273(5):H2534-8
references.pmid: 9374794
references.citation: ANZ J Surg. 2007 May;77(5):320-8
references.pmid: 17497967
references.citation: Gastroenterology. 2006 Apr;130(5):1480-91
references.pmid: 16678561
references.citation: Pharmacotherapy. 1991;11(3):196-211
references.pmid: 1862011
references.citation: Gastroenterol Clin North Am. 2003 Jun;32(2):659-83
references.pmid: 12858610
references.citation: World J Gastroenterol. 2005 May 14;11(18):2691-6
references.pmid: 15884105
references.citation: Gastroenterology. 2000 Dec;119(6):1766-78
references.pmid: 11113099
references.citation: Ann Surg. 1999 Nov;230(5):627-38
references.pmid: 10561086
references.citation: Dig Dis Sci. 1994 May;39(5):929-33
references.pmid: 8174433
references.citation: Acta Pharmacol Toxicol (Copenh). 1978 Oct;43(4):251-9
references.pmid: 716941
references.citation: Am J Med Sci. 1970 Jan;259(1):32-41
references.pmid: 5416781
references.citation: Aliment Pharmacol Ther. 2008 Apr;27(8):685-96
references.pmid: 18248656
references.citation: Best Pract Res Clin Gastroenterol. 2007;21(4):709-31
references.pmid: 17643910