title: Ustekinumab in the therapy of chronic plaque psoriasis.
abstract: Psoriasis is a chronic inflammatory disorder characterized by T cell dysregulation and a chronic inflammatory infiltrate within the epidermis. Several cytokines play an important role in the pathogenesis of psoriasis, including interleukin-12 (IL-12) and IL-23. These cytokines act via induction of pro-inflammatory cytokines which promote chronic inflammation and auto-reactivity. Ustekinumab is a fully human monoclonal antibody against the common p40 subunit of IL-12 and IL-23. Two randomized, double-blind, placebo-controlled trials of ustekinumab have demonstrated significant and prolonged efficacy in the treatment of plaque psoriasis. Adverse events were generally similar across treatment and control groups. Studies are ongoing to assess the long term safety and efficacy profiles of ustekinumab.
authors.affiliation: State University of New York, at Buffalo, School of Medicine and Biomedical Sciences, Department of Dermatology, NY, USA.
authors.forename: Jenna L
authors.initials: JL
authors.lastname: O'Neill
authors.forename: Robert E
authors.initials: RE
authors.lastname: Kalb
references.citation: N Engl J Med. 2007 Feb 8;356(6):580-92
references.pmid: 17287478
references.citation: J Immunol. 1999 Apr 1;162(7):4069-78
references.pmid: 10201930
references.citation: Arch Dermatol Res (1975). 1977 Mar 25;258(1):9-16
references.pmid: 857738
references.citation: J Invest Dermatol. 1999 Nov;113(5):752-9
references.pmid: 10571730
references.citation: J Am Acad Dermatol. 2007 Dec;57(6):1059-68
references.pmid: 17706835
references.citation: J Exp Med. 1995 Jan 1;181(1):381-6
references.pmid: 7528773
references.citation: Curr Med Res Opin. 2007 May;23(5):1081-92
references.pmid: 17519075
references.citation: Br J Dermatol. 2008 May;158(5):1107-16
references.pmid: 18373710
references.citation: Lancet Neurol. 2008 Sep;7(9):796-804
references.pmid: 18703004
references.citation: Nat Immunol. 2002 Jun;3(6):549-57
references.pmid: 12006974
references.citation: Nat Immunol. 2007 Sep;8(9):950-7
references.pmid: 17676044
references.citation: J Exp Med. 2006 Nov 27;203(12):2577-87
references.pmid: 17074928
references.citation: Nat Immunol. 2005 Nov;6(11):1133-41
references.pmid: 16200068
references.citation: Clin Exp Immunol. 1998 Feb;111(2):377-83
references.pmid: 9486407
references.citation: Arch Dermatol. 1974 Feb;109(2):207-11
references.pmid: 4814926
references.citation: Arch Dermatol. 1999 Sep;135(9):1104-10
references.pmid: 10490116
references.citation: N Engl J Med. 2003 Nov 20;349(21):2004-13
references.pmid: 14627785
references.citation: Int J Biochem Cell Biol. 2009 Apr;41(4):733-5
references.pmid: 18725317
references.citation: J Exp Med. 2004 Mar 1;199(5):731-6
references.pmid: 14981113
references.citation: Immunity. 2000 Nov;13(5):715-25
references.pmid: 11114383
references.citation: JAMA. 2008 Oct 22;300(16):1887-96
references.pmid: 18940975
references.citation: Arch Dermatol. 2003 Jun;139(6):719-27
references.pmid: 12810502
references.citation: J Immunol. 2006 Oct 1;177(7):4917-26
references.pmid: 16982934
references.citation: Cochrane Database Syst Rev. 2000;(2):CD001976
references.pmid: 10796842
references.citation: J Invest Dermatol. 2004 Dec;123(6):1037-44
references.pmid: 15610511
references.citation: Immunity. 1996 May;4(5):471-81
references.pmid: 8630732
references.citation: J Invest Dermatol. 1998 Oct;111(4):645-9
references.pmid: 9764847
references.citation: J Immunol. 1991 Aug 1;147(3):874-82
references.pmid: 1713608
references.citation: Lancet. 2008 May 17;371(9625):1675-84
references.pmid: 18486740
references.citation: Eur J Immunol. 2002 Jan;32(1):261-9
references.pmid: 11782017
references.citation: J Immunol. 2004 Mar 1;172(5):2827-33
references.pmid: 14978083
references.citation: J Biol Chem. 2003 Jan 17;278(3):1910-4
references.pmid: 12417590
references.citation: Immunol Rev. 2004 Dec;202:96-105
references.pmid: 15546388
references.citation: J Immunol. 2006 May 1;176(9):5213-22
references.pmid: 16621986
references.citation: Eur J Immunol. 1996 Jul;26(7):1621-7
references.pmid: 8766570
references.citation: Science. 1998 May 29;280(5368):1435-8
references.pmid: 9603733
references.citation: Cytokine. 1999 Nov;11(11):822-30
references.pmid: 10547269
references.citation: J Invest Dermatol. 1998 Dec;111(6):1053-7
references.pmid: 9856816
references.citation: Lancet. 2008 May 17;371(9625):1665-74
references.pmid: 18486739
references.citation: N Engl J Med. 2005 May 5;352(18):1899-912
references.pmid: 15872205
references.citation: Eur J Immunol. 2006 May;36(5):1309-23
references.pmid: 16619290
references.citation: J Clin Invest. 1999 Dec;104(11):1527-37
references.pmid: 10587516
references.citation: Adv Immunol. 2001;79:55-92
references.pmid: 11680011
references.citation: Arch Dermatol. 2007 Jun;143(6):719-26
references.pmid: 17576937
references.citation: J Immunol. 2004 Aug 1;173(3):1887-93
references.pmid: 15265921
references.citation: Trends Immunol. 2006 Jan;27(1):17-23
references.pmid: 16290228
references.citation: J Exp Med. 1996 Aug 1;184(2):747-52
references.pmid: 8760829
references.citation: J Exp Med. 1996 Jan 1;183(1):147-57
references.pmid: 8551218
references.citation: J Dermatolog Treat. 2008;19(5):259-66
references.pmid: 18629676
references.citation: J Am Acad Dermatol. 2006 Nov;55(5):829-35
references.pmid: 17052489
references.citation: J Immunol. 1997 Aug 15;159(4):1658-65
references.pmid: 9257825
references.citation: J Exp Med. 2006 Oct 2;203(10):2271-9
references.pmid: 16982811
references.citation: J Clin Invest. 2002 Aug;110(4):493-7
references.pmid: 12189243
references.citation: Crit Rev Immunol. 2004;24(2):111-28
references.pmid: 15581393
references.citation: J Immunol. 2002 Jun 1;168(11):5699-708
references.pmid: 12023369
references.citation: Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):14002-7
references.pmid: 8943050
references.citation: Cytokine Growth Factor Rev. 2003 Oct;14(5):361-8
references.pmid: 12948519
references.citation: J Immunol. 1999 Jun 15;162(12):7480-91
references.pmid: 10358203
references.citation: Arch Dermatol Res. 1983;275(3):181-9
references.pmid: 6604503
references.citation: Expert Opin Ther Targets. 2005 Dec;9(6):1123-36
references.pmid: 16300465
references.citation: J Immunol. 2002 Jun 1;168(11):5448-54
references.pmid: 12023338
references.citation: Eur J Immunol. 1993 Aug;23(8):1762-70
references.pmid: 8102100
references.citation: Annu Rev Immunol. 1989;7:145-73
references.pmid: 2523712
references.citation: N Engl J Med. 2003 Nov 20;349(21):2014-22
references.pmid: 14627786
references.citation: Immunity. 1998 Sep;9(3):315-23
references.pmid: 9768751
references.citation: Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):15137-42
references.pmid: 11752460
references.citation: Nature. 2007 Feb 8;445(7128):648-51
references.pmid: 17187052
references.citation: Gut. 2007 Oct;56(10):1333-6
references.pmid: 17872562
references.citation: Eur J Immunol. 1996 Jul;26(7):1647-51
references.pmid: 8766574
references.citation: J Immunol. 2002 Dec 1;169(11):6554-63
references.pmid: 12444167
references.citation: Curr Opin Immunol. 2007 Jun;19(3):281-6
references.pmid: 17433650
references.citation: Mol Immunol. 2002 May;38(12-13):903-9
references.pmid: 12009568
references.citation: Arch Dermatol. 1972 Feb;105(2):197-207
references.pmid: 5060862
references.citation: J Exp Med. 2000 Jul 3;192(1):123-8
references.pmid: 10880533
references.citation: Arch Dermatol. 1990 Nov;126(11):1523
references.pmid: 2241215
references.citation: Nat Immunol. 2005 Nov;6(11):1069-70
references.pmid: 16239919
references.citation: Curr Opin Immunol. 2006 Dec;18(6):670-5
references.pmid: 17010592
references.citation: Gastroenterology. 2008 Oct;135(4):1130-41
references.pmid: 18706417
references.citation: J Exp Med. 2004 Jan 5;199(1):125-30
references.pmid: 14707118
references.citation: Cytokine Growth Factor Rev. 2002 Apr;13(2):155-68
references.pmid: 11900991
references.citation: N Engl J Med. 1979 Sep 6;301(10):555
references.pmid: 460314