title: Antimicrobial activity of Gentiana lutea L. extracts.
abstract: Methanolic extracts of flowers and leaves of Gentiana lutea L., together with the isolated compounds mangiferin, isogentisin and gentiopicrin, were used to investigate the antimicrobial activity of the plant. A variety of Gram-positive and Gram-negative bacteria as well as the yeast Candida albicans has been included in this study. Both extracts and isolated compounds showed antimicrobial activity with MIC values ranging from 0.12-0.31 mg/ml. Our study indicated that the synergistic activity of the pure compounds may be responsible for the good antimicrobial effect of the extracts. Quantification of the secondary metabolites was performed using HPLC.
authors.affiliation: Institute for Medicinal Plants Research, Tadeusa Koscuska 1, 11000 Belgrade, Serbia. ksavikin@mocbilja.rs
authors.forename: Katarina
authors.initials: K
authors.lastname: Savikin
authors.forename: Nebojsa
authors.initials: N
authors.lastname: Menković
authors.forename: Gordana
authors.initials: G
authors.lastname: Zdunić
authors.forename: Tatjana
authors.initials: T
authors.lastname: Stević
authors.forename: Dragoja
authors.initials: D
authors.lastname: Radanović
authors.forename: Teodora
authors.initials: T
authors.lastname: Janković
mesh_terms: D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects*; D002851:Chromatography, High Pressure Liquid; D035264:Flowers / Q000737:chemistry*; D030012:Gentiana; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000302:isolation & purification / Q000627:therapeutic use*; D018515:Plant Leaves / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D010936:Plant Extracts