title: ISCR2, another vehicle for bla(VEB) gene acquisition.
abstract: The expanded-spectrum beta-lactamase (ESBL) gene bla(VEB-1), identified worldwide in Enterobacteriaceae and Pseudomonas aeruginosa, is associated with either class 1 integrons or repeated elements. We report here the first association of bla(VEB-1a) with the insertion sequence ISCR2 in six Acinetobacter species isolates recovered from Argentina. That genetic structure was likely at the origin of the mobilization of this ESBL gene.
authors.affiliation: Service de Bactériologie-Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris-Sud et Université Paris-Sud, Le Kremlin-Bicêtre, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Poirel
authors.forename: Pauline D
authors.initials: PD
authors.lastname: Mugnier
authors.forename: Mark A
authors.initials: MA
authors.lastname: Toleman
authors.forename: Timothy R
authors.initials: TR
authors.lastname: Walsh
authors.forename: Melina J
authors.initials: MJ
authors.lastname: Rapoport
authors.forename: Alejandro
authors.initials: A
authors.lastname: Petroni
authors.forename: Patrice
authors.initials: P
authors.lastname: Nordmann
mesh_terms: D000150:Acinetobacter / Q000201:enzymology / Q000235:genetics*; D000595:Amino Acid Sequence; D001483:Base Sequence; D004251:DNA Transposable Elements; D029968:Escherichia coli Proteins; D008969:Molecular Sequence Data; D001618:beta-Lactamases / Q000737:chemistry / Q000235:genetics*
chemical_list: D004251:DNA Transposable Elements; D029968:Escherichia coli Proteins; C119424:beta-lactamase VEB-1, E coli; D001618:beta-Lactamases
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