title: Redrawing the borderline: Control of DNA replication at fertilization.
abstract: In our recent paper in Plant Journal, we described the transcriptional activation of AtTMPK (thymidylate kinase),1 a recognized G(1)/S phase marker of the cell cycle progression and its role in early seed development. Here, we compare our conclusions on the regulation of AtTMPK and those of other genes participating in DNA replication, including DPB2, a subunit of the DNA polymerase epsilon complex.2 Although, the dual localisation of AtTMPK in the cytosol and mitochondria seems to be unique to plants, this phenomenon of multiple targeting is also used for other proteins involved in DNA replication, such as DNA ligase 1 (AtLIG1), and may represent a way to coordinate nuclear and organellar divisions.
authors.affiliation: Laboratoire Génome et Développement des Plantes; UMR-CNRS-IRD-Université 5096; Perpignan, France.
authors.forename: Arnaud
authors.initials: A
authors.lastname: Ronceret
authors.forename: Martine
authors.initials: M
authors.lastname: Devic
references.citation: Mol Genet Genomics. 2004 Jul;271(6):651-7
references.pmid: 15221456
references.citation: Development. 2000 May;127(9):1815-22
references.pmid: 10751170
references.citation: Plant J. 2006 Aug;47(3):356-67
references.pmid: 16790030
references.citation: Plant Cell. 2004 Apr;16(4):1035-46
references.pmid: 15020747
references.citation: Plant J. 1998 Sep;15(5):635-45
references.pmid: 9778846
references.citation: Plant J. 2005 Oct;44(2):223-36
references.pmid: 16212602
references.citation: Proc Natl Acad Sci U S A. 2005 Jun 7;102(23):8216-21
references.pmid: 15928083
references.citation: Development. 2005 Feb;132(3):603-14
references.pmid: 15634699
references.citation: Plant J. 2008 Mar;53(5):776-89
references.pmid: 18036198
references.citation: Plant J. 2007 Dec;52(5):817-23
references.pmid: 17931353