title: Hippocampal volumetry and functional MRI of memory in temporal lobe epilepsy.
abstract: This study examined the utility of structural and functional MRI at 1.5 and 3T in the presurgical evaluation and prediction of postsurgical cognitive outcome in temporal lobe epilepsy (TLE). Forty-nine patients undergoing presurgical evaluation for temporal lobe (TL) resection and 25 control subjects were studied. Patients completed standard presurgical evaluations, including the intracarotid amobarbital test (IAT) and neuropsychological testing. During functional imaging, subjects performed a complex visual scene-encoding task. High-resolution structural MRI scans were used to quantify hippocampal volumes. Both structural and functional imaging successfully lateralized the seizure focus and correlated with IAT memory lateralization, with improvement for functional imaging at 3T as compared with 1.5 T. Ipsilateral structural and functional MRI data were related to cognitive outcome, and greater functional asymmetry was related to earlier age at onset. These findings support continued investigation of the utility of MRI and fMRI in the presurgical evaluation of TLE.
authors.affiliation: Center for Functional Neuroimaging, University of Pennsylvania, Philadelphia, PA, USA.
authors.forename: Dawn
authors.initials: D
authors.lastname: Mechanic-Hamilton
authors.forename: Marc
authors.initials: M
authors.lastname: Korczykowski
authors.forename: Paul A
authors.initials: PA
authors.lastname: Yushkevich
authors.forename: Kathy
authors.initials: K
authors.lastname: Lawler
authors.forename: John
authors.initials: J
authors.lastname: Pluta
authors.forename: Simon
authors.initials: S
authors.lastname: Glynn
authors.forename: Joseph I
authors.initials: JI
authors.lastname: Tracy
authors.forename: Ronald L
authors.initials: RL
authors.lastname: Wolf
authors.forename: Michael R
authors.initials: MR
authors.lastname: Sperling
authors.forename: Jacqueline A
authors.initials: JA
authors.lastname: French
authors.forename: John A
authors.initials: JA
authors.lastname: Detre
mesh_terms: D000328:Adult; D017668:Age of Onset; D003071:Cognition / Q000502:physiology; D015331:Cohort Studies; D004292:Dominance, Cerebral; D004833:Epilepsy, Temporal Lobe / Q000473:pathology* / Q000523:psychology* / Q000601:surgery; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D016014:Linear Models; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory / Q000502:physiology*; D009483:Neuropsychological Tests; D019635:Neurosurgical Procedures; D015203:Reproducibility of Results; D016896:Treatment Outcome
references.citation: J Neurol Neurosurg Psychiatry. 1999 Jul;67(1):44-50
references.pmid: 10369821
references.citation: Epilepsia. 2006 Mar;47(3):615-25
references.pmid: 16529630
references.citation: Epilepsia. 2001;42 Suppl 6:4-8
references.pmid: 11902321
references.citation: Epilepsia. 2001 Nov;42(11):1408-15
references.pmid: 11879343
references.citation: J Clin Exp Neuropsychol. 2002 Aug;24(5):664-76
references.pmid: 12187449
references.citation: Epilepsy Res. 2008 Nov;82(1):29-37
references.pmid: 18691850
references.citation: J Neurol Neurosurg Psychiatry. 2004 Nov;75(11):1589-96
references.pmid: 15489392
references.citation: Epilepsia. 2002 Aug;43(8):855-63
references.pmid: 12181004
references.citation: Arch Neurol. 2002 Dec;59(12):1895-901
references.pmid: 12470177
references.citation: Epilepsia. 1996 Jun;37(6):526-33
references.pmid: 8641228
references.citation: Radiology. 2005 Sep;236(3):996-1003
references.pmid: 16118173
references.citation: Brain. 2004 Nov;127(Pt 11):2419-26
references.pmid: 15459025
references.citation: Proc Natl Acad Sci U S A. 1996 Aug 6;93(16):8660-5
references.pmid: 8710927
references.citation: Neurology. 1992 Sep;42(9):1743-50
references.pmid: 1513464
references.citation: Neurology. 2006 Mar 14;66(5):699-705
references.pmid: 16534106
references.citation: Epilepsia. 2007 Mar;48(3):553-8
references.pmid: 17319921
references.citation: Arch Clin Neuropsychol. 2006 Aug;21(5):413-20
references.pmid: 16843636
references.citation: Epilepsy Behav. 2004 Apr;5(2):244-52
references.pmid: 15123027
references.citation: J Magn Reson Imaging. 2004 Jan;19(1):19-26
references.pmid: 14696216
references.citation: Brain. 1999 Nov;122 ( Pt 11):2033-46
references.pmid: 10545389
references.citation: Neuropsychology. 1998 Apr;12(2):303-16
references.pmid: 9556776
references.citation: Neurosurgery. 1996 Apr;38(4):640-9; discussion 649-51
references.pmid: 8692380
references.citation: J Int Neuropsychol Soc. 2007 Jul;13(4):664-71
references.pmid: 17521492
references.citation: J Neurol Neurosurg Psychiatry. 2003 Dec;74(12):1627-30
references.pmid: 14638879
references.citation: Neurology. 2003 Mar 25;60(6):951-9
references.pmid: 12654959
references.citation: Hippocampus. 2003;13(8):892-904
references.pmid: 14750652
references.citation: Brain. 2007 May;130(Pt 5):1423-31
references.pmid: 17439989
references.citation: Magn Reson Imaging. 1995;13(8):1057-64
references.pmid: 8750317
references.citation: Epilepsia. 2001 Jul;42(7):902-11
references.pmid: 11488891
references.citation: Neuroimage. 2002 May;16(1):23-31
references.pmid: 11969314
references.citation: Brain. 2003 Feb;126(Pt 2):462-9
references.pmid: 12538412
references.citation: Neurology. 1993 Apr;43(4):719-25
references.pmid: 8469329
references.citation: Epilepsy Behav. 2005 Mar;6(2):207-11
references.pmid: 15710306
references.citation: Neuroimage. 2006 Aug 15;32(2):592-602
references.pmid: 16777435
references.citation: Epilepsia. 2005 Feb;46(2):244-50
references.pmid: 15679505
references.citation: Neuroimage. 2002 Sep;17(1):447-60
references.pmid: 12482097
references.citation: Neuropsychol Rev. 2000 Mar;10(1):41-74
references.pmid: 10839312
references.citation: Neurology. 1996 Apr;46(4):978-84
references.pmid: 8780076
references.citation: Epilepsia. 2002 Sep;43(9):1062-71
references.pmid: 12199732
references.citation: Neuroimage. 2005 Oct 1;27(4):979-90
references.pmid: 15990339
references.citation: Seizure. 1999 Dec;8(8):450-5
references.pmid: 10627406
references.citation: Epilepsy Res. 1990 May-Jun;6(1):56-65
references.pmid: 2357956
references.citation: Neuroimage. 2007 May 1;35(4):1516-30
references.pmid: 17383900
references.citation: Eur Radiol. 2008 Jun;18(6):1102-13
references.pmid: 18274756
references.citation: Seizure. 2005 Dec;14(8):562-8
references.pmid: 16236531
references.citation: J Exp Psychol Gen. 1988 Mar;117(1):34-50
references.pmid: 2966230
references.citation: Epilepsia. 1995 Sep;36(9):857-65
references.pmid: 7649125
references.citation: Epilepsia. 2002 Dec;43(12):1551-8
references.pmid: 12460258
references.citation: J Clin Exp Neuropsychol. 2007 Jan;29(1):13-24
references.pmid: 17162718
references.citation: Neurology. 2004 Oct 26;63(8):1403-8
references.pmid: 15505156
references.citation: Radiology. 1997 Feb;202(2):504-10
references.pmid: 9015081
references.citation: Arch Clin Neuropsychol. 1995 Oct;10(5):413-32
references.pmid: 14588901
references.citation: Neuroimage. 2007 Jan 15;34(2):542-9
references.pmid: 17101280
references.citation: Magn Reson Med. 2005 Sep;54(3):732-7
references.pmid: 16086314
references.citation: Neurology. 2003 Feb 25;60(4):538-47
references.pmid: 12601090
references.citation: Hippocampus. 2002;12(6):718-23
references.pmid: 12542224
references.citation: Epilepsia. 2006 Nov;47(11):1887-94
references.pmid: 17116029
references.citation: Neuroimage. 2009 Oct 1;47(4):1425-34
references.pmid: 19446641
references.citation: Epilepsia. 2005 Jul;46(7):1061-70
references.pmid: 16026558
references.citation: Epilepsia. 2004 Aug;45(8):960-2
references.pmid: 15270763
references.citation: J Neurosurg. 2006 Jan;104(1):70-8
references.pmid: 16509149
references.citation: Epilepsy Behav. 2006 Aug;9(1):95-100
references.pmid: 16716754
references.citation: Neurology. 2001 Aug 28;57(4):597-604
references.pmid: 11524466
references.citation: Hum Brain Mapp. 2007 Dec;28(12):1391-400
references.pmid: 17525983
references.citation: Neurology. 1994 Dec;44(12):2331-6
references.pmid: 7991121
references.citation: Epilepsy Behav. 2005 Mar;6(2):242-9
references.pmid: 15710311
references.citation: J Neurol Neurosurg Psychiatry. 2008 Jun;79(6):686-93
references.pmid: 17898035
references.citation: Neurology. 2001 Nov 27;57(10):1786-93
references.pmid: 11723264
references.citation: Neuroimage. 2006 Jul 1;31(3):1116-28
references.pmid: 16545965
references.citation: Brain Lang. 2002 Mar;80(3):421-37
references.pmid: 11896650
references.citation: Brain. 2004 Oct;127(Pt 10):2286-98
references.pmid: 15329352
references.citation: Magn Reson Med. 2005 Nov;54(5):1241-7
references.pmid: 16193469
references.citation: Epilepsia. 1995 Feb;36(2):137-45
references.pmid: 7821270
references.citation: J Neurosurg. 2004 Dec;101(6):926-31
references.pmid: 15597752
references.citation: Epilepsia. 2005 Mar;46(3):420-30
references.pmid: 15730540