title: Structural polymorphism of the mannose-binding lectin 2 (MBL2 ) gene in HCV-infected patients with a serological marker for thyroid autoimmunity.
abstract: We studied the association of the mannose-binding lectin-2 (MBL2) polymorphism with anti-thyroid antibodies (ATA) in hepatitis C virus (HCV)-infected Brazilian patients (n = 162) and 124 healthy volunteers screened for ATA. Our results showed that patients with ATA had higher frequency of genotype 00 than controls. MBL may play a role as disease modifier in HCV infection.
authors.affiliation: Postgraduate Program in Tropical Medicine, Federal University of Pernambuco (UFPE), Pernambuco, Brazil.
authors.forename: F M
authors.initials: FM
authors.lastname: Melo
authors.forename: L R S
authors.initials: LR
authors.lastname: Vasconcelos
authors.forename: B S
authors.initials: BS
authors.lastname: Silva
authors.forename: P
authors.initials: P
authors.lastname: Moura
authors.forename: M S M
authors.initials: MS
authors.lastname: Cavalcanti
authors.forename: L M M B
authors.initials: LM
authors.lastname: Pereira
authors.forename: H R
authors.initials: HR
authors.lastname: Lacerda
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015551:Autoimmunity / Q000235:genetics*; D001938:Brazil; D016022:Case-Control Studies; D005260:Female; D016174:Hepacivirus / Q000276:immunology*; D006526:Hepatitis C / Q000097:blood* / Q000235:genetics; D006801:Humans; D008297:Male; D037601:Mannose-Binding Lectin / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic; D013961:Thyroid Gland / Q000276:immunology*
chemical_list: C445619:MBL2 protein, human; D037601:Mannose-Binding Lectin