Continued effects of prenatal cocaine use: preschool development.
The relationship between prenatal cocaine use and preschooler's physical and cognitive development and behavioral characteristics was examined, controlling for other influences on child development. On average, children were 38.5 months old, women were 29.4 years old, had 12.3 years of education, and 47% were African American. During the first trimester, 18% of the women were frequent cocaine users (> or = 1 line/day). First trimester cocaine exposure predicted decreased head circumference at 3 years and lower scores on the short-term memory subscale of the Stanford-Binet Intelligence Scale (SBIS) [74]. There was no significant relationship between prenatal cocaine use and the other SBIS scales. First trimester cocaine use also predicted more total, internalizing, and externalizing behavior problems on the Child Behavior Checklist [3] and higher scores on the fussy/difficult scale of the Infant Characteristics Questionnaire [6]. Children who were exposed to cocaine throughout pregnancy had more behavior problems and were more fussy compared to children of women who never used cocaine prenatally. A repeated measures analysis showed that children of first trimester cocaine users became more fussy over time. These detrimental effects on growth and behavior are consistent with other reports in the literature and with the hypothesis that prenatal cocaine exposure affects development through changes in neurotransmitter systems.
Richardson
Gale A
GA
University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O'Hara Street, Pittsburgh, PA 15213, USA. gar@pitt.edu
Goldschmidt
Lidush
L
Willford
Jennifer
J
D000328:Adult; D000368:Aged; D001827:Body Height / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002653:Child Behavior Disorders / Q000139:chemically induced; D002657:Child Development / Q000187:drug effects*; D002675:Child, Preschool; D003042:Cocaine / Q000633:toxicity*; D019970:Cocaine-Related Disorders / Q000523:psychology*; D003071:Cognition / Q000187:drug effects; D005260:Female; D006257:Head / Q000033:anatomy & histology; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D011247:Pregnancy; D011248:Pregnancy Complications; D011261:Pregnancy Trimester, First; D011297:Prenatal Exposure Delayed Effects / Q000523:psychology*
D003042:Cocaine
Neurotoxicol Teratol. 2005 Jan-Feb;27(1):15-28
15681118
Pediatrics. 2004 Jun;113(6):1677-85
15173491
J Dev Behav Pediatr. 2007 Jun;28(3):195-205
17565286
Pediatrics. 1989 Sep;84(3):536-41
2771556
Psychopharmacology (Berl). 1993;112(4):445-51
7871055
Neurotoxicol Teratol. 1999 Sep-Oct;21(5):513-25
10492386
J Clin Invest. 1994 Mar;93(3):1179-85
8132758
J Dev Behav Pediatr. 2003 Oct;24(5):345-51
14578695
Dev Psychopathol. 1997 Summer;9(3):473-89
9327234
J Pediatr Psychol. 2006 Jan-Feb;31(1):71-84
15827351
JAMA. 2004 May 26;291(20):2448-56
15161895
Ann N Y Acad Sci. 1998 Jun 21;846:165-81
9668406
J Dev Behav Pediatr. 2000 Feb;21(1):19-26
10706345
N Engl J Med. 1989 Mar 23;320(12):762-8
2784193
J Dev Behav Pediatr. 2006 Apr;27(2):83-92
16682870
J Pharmacol Exp Ther. 1992 Nov;263(2):413-21
1331397
J Pers Soc Psychol. 2004 Jan;86(1):112-29
14717631
Pediatrics. 2007 Oct;120(4):e1017-27
17893189
Clin Invest Med. 2001 Jun;24(3):129-37
11437064
Neurotoxicol Teratol. 2007 May-Jun;29(3):331-40
17258430
J Dev Behav Pediatr. 1999 Dec;20(6):418-24
10608371
J Child Psychol Psychiatry. 1994 Sep;35(6):1109-22
7995846
Brain Res Dev Brain Res. 1995 Mar 16;85(1):48-53
7781166
Pediatrics. 2007 Feb;119(2):e348-59
17272597
J Am Acad Child Adolesc Psychiatry. 1997 Mar;36(3):374-83
9055518
J Am Acad Child Adolesc Psychiatry. 2001 Jan;40(1):36-43
11195559
J Pediatr Psychol. 2004 Oct;29(7):543-54
15347702
Pediatrics. 2001 Feb;107(2):309-17
11158464
Dev Psychol. 2008 Jul;44(4):919-28
18605824
Drug Alcohol Depend. 1998 Jun-Jul;51(1-2):109-25
9716934
J Neurosci. 1990 Jul;10(7):2125-38
2165520
Adv Data. 2000 Jun 8;(314):1-27
11183293
Neurotoxicol Teratol. 1996 Sep-Oct;18(5):519-28
8888016
Neurotoxicol Teratol. 1994 Jan-Feb;16(1):81-7
8183193
Neurotoxicol Teratol. 2008 Mar-Apr;30(2):96-106
18243651
Dev Neurosci. 2009;31(1-2):149-58
19372695
J Pediatr Psychol. 2002 Apr-May;27(3):259-69
11909933
Dev Psychol. 2002 Sep;38(5):648-58
12220044
Pediatrics. 2000 Jan;105(1 Pt 1):39-48
10617702
Dev Psychol. 2006 Jul;42(4):688-97
16802901
J Am Acad Child Adolesc Psychiatry. 1987 Jul;26(4):491-8
3654499
Child Dev. 1979 Sep;50(3):794-803
498854
Acta Paediatr Suppl. 1994 Dec;406:3-9; discussion 10
7734809
J Dev Behav Pediatr. 2004 Feb;25(1):1-9
14767350
Child Dev. 1996 Apr;67(2):396-408
8625720
Crit Rev Neurobiol. 1995;9(4):395-418
8829853
Am J Drug Alcohol Abuse. 2004 May;30(2):299-320
15230078
Neurosci Biobehav Rev. 2004 Jan;27(8):751-64
15019425
Neurotoxicol Teratol. 1994 Mar-Apr;16(2):169-75
8052191
Pediatrics. 1999 Aug;104(2):e18
10429136
Neurotoxicol Teratol. 1991 May-Jun;13(3):329-34
1886543
Neurotoxicol Teratol. 2001 Nov-Dec;23(6):545-59
11792524
J Pediatr Psychol. 2006 Jan-Feb;31(1):41-9
15827349
Neurotoxicol Teratol. 1992 Nov-Dec;14(6):407-14
1488035
Neurotoxicol Teratol. 2002 Nov-Dec;24(6):703-10
12460652
J Am Acad Child Adolesc Psychiatry. 1994 Jan;33(1):20-7
7511139
Cell Tissue Res. 2001 Aug;305(2):177-86
11545255
Ann N Y Acad Sci. 1989;562:8-13
2742287
Neurotoxicol Teratol. 2007 Jul-Aug;29(4):446-57
17412558
J Dev Behav Pediatr. 2001 Feb;22(1):27-34
11265920
Clin Obstet Gynecol. 1993 Jun;36(2):302-18
8513626
Ann N Y Acad Sci. 1998 Jun;846(1):158-164
29087559