title: Narrow-band imaging bronchoscopy increases the specificity of bronchoscopic early lung cancer detection.
abstract: BACKGROUND
  Detection of nonsmall cell lung cancer at the intraepithelial stage is believed to improve cure rates. New bronchoscopic technologies, including white light videobronchoscopy (WLB), autofluorescence imaging (AFI), and narrow band imaging (NBI), are aiming to diagnose airway neoplasia at a preinvasive stage.
  
  
  OBJECTIVE
  : To evaluate the diagnostic yields of NBI individually and in combination with WLB and AFI.
  
  
  METHODS
  A 10-month review of patients who were referred for airway screening or surveillance. Patients were randomized as to the order of AFI and NBI examinations. The airway mucosa was graded endoscopically as "normal," "abnormal," "suspicious," or "tumor." All areas that were not normal were biopsied. Biopsies with a histologic grading of moderate to severe dysplasia or carcinoma in situ were considered positive for intraepithelial neoplasia.
  
  
  RESULTS
  Sixty-two patients with a mean age of 56.2 +/- 9.8 years were studied. Five patients had invasive cancers and were excluded from the analysis. The remaining 57 cases had a 30% prevalence of intraepithelial neoplasia. The sensitivity of WLB was 0.18 and the specificity was 0.88. The relative sensitivities (compared with WLB) of AFI and NBI were 3.7 (p = 0.005) and 3.0 (p = 0.03), respectively. The relative specificities of AFI and NBI were 0.5 (p < 0.001) and 1.0 (p = 0.72), respectively. Combining AFI and NBI did not increase diagnostic yield significantly. The sequence of performing AFI and NBI did not impact findings.
  
  
  CONCLUSIONS
  NBI is an alternative to AFI in the detection of early lung cancers because it has a comparatively higher specificity without significantly compromising the sensitivity.
authors.affiliation: Department of Pneumology and Critical Care Medicine, Thoraxklinik, University of Heidelberg, Germany. thoraxklinik-heidelberg.de
authors.forename: Felix J F
authors.initials: FJ
authors.lastname: Herth
authors.forename: Ralf
authors.initials: R
authors.lastname: Eberhardt
authors.forename: Devanand
authors.initials: D
authors.lastname: Anantham
authors.forename: Daniela
authors.initials: D
authors.lastname: Gompelmann
authors.forename: Mohamed Wafaa
authors.initials: MW
authors.lastname: Zakaria
authors.forename: Armin
authors.initials: A
authors.lastname: Ernst
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001999:Bronchoscopy / Q000379:methods*; D055088:Early Detection of Cancer; D005260:Female; D005453:Fluorescence; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity