title: Effects of cadmium on absorption, excretion, and distribution of nickel in rats.
abstract: The effects of cadmium (Cd (II)) on absorption, excretion, and distribution of nickel (Ni (II)) were studied in rats using (63)Ni-NiCl(2) as radiotracer in the presence and absence of CdCl(2), through intraperitoneal injection (i.p.). The time-concentration curves in the blood were fitted with a two-compartment model. The peak time (t ((peak))) is 0.31 h in the absence of Cd (II), and it is 5.5 h in the presence of Cd (II). The levels of nickels were higher at 3 h and lower (close to zero) at 24 h in all organs of interest, except kidneys, in the absence of Cd (II). There still residue Ni (II) at 72 h post-injection in the presence of Cd (II). The Cd (II) did effect the total Ni (II) excretion 24 h post-injection. Our study showed that cadmium has a competitive effect on the absorption of nickel and an inhibitory effect on the elimination of it, so cadmium may induce the bioaccumulation of nickel in the body.
authors.affiliation: Radiochemistry Laboratory, Lanzhou University, Lanzhou 73000, People's Republic of China.
authors.forename: Zhan
authors.initials: Z
authors.lastname: Li
authors.forename: Jun-Ying
authors.initials: JY
authors.lastname: Gu
authors.forename: Xian-Wen
authors.initials: XW
authors.lastname: Wang
authors.forename: Qiao-Hui
authors.initials: QH
authors.lastname: Fan
authors.forename: Yan-Xia
authors.initials: YX
authors.lastname: Geng
authors.forename: Zong-Xian
authors.initials: ZX
authors.lastname: Jiao
authors.forename: Yi-Ping
authors.initials: YP
authors.lastname: Hou
authors.forename: Wang-Suo
authors.initials: WS
authors.lastname: Wu
mesh_terms: D000042:Absorption; D000818:Animals; D019256:Cadmium Chloride / Q000494:pharmacology*; D009532:Nickel / Q000097:blood / Q000493:pharmacokinetics*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D009532:Nickel; D019256:Cadmium Chloride