Mutagenic activity of potentiated antibodies to erythropoietin.
Single and repeated administration of ultralow doses of antibodies to erythropoietin did not increase the count of aberrant metaphases in bone marrow cells of BALB/c mice and were not genotoxic for Drosophila melanogaster wing cells in the test of somatic mosaicism.
Voronova
O L
OL
Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences.
Rogozina
O P
OP
Dugina
Yu L
YL
Martyushev
A V
AV
Epstein
O I
OI
Dygai
A M
AM
Goldberg
E D
ED
D000818:Animals; D000906:Antibodies / Q000633:toxicity*; D001854:Bone Marrow Cells / Q000166:cytology / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004331:Drosophila melanogaster / Q000187:drug effects*; D004921:Erythropoietin / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D009030:Mosaicism / Q000139:chemically induced; D009152:Mutagenicity Tests; D014921:Wings, Animal / Q000166:cytology
D000906:Antibodies; D004921:Erythropoietin