title: Evaluation of depressive symptoms in acne patients treated with isotretinoin.
abstract: BACKGROUND
  There have been concerns about the association between isotretinoin therapy and depressive symptoms.
  
  
  OBJECTIVE
  The objective of this study is to evaluate whether there is an association between isotretinoin therapy and the onset of depression.
  
  
  METHODS
  A total of 50 patients with moderate to severe recalcitrant acne and 30 healthy volunteer people were enrolled in the study. Depressive symptoms and anxiety status were assessed at baseline and then 1 and 4 months after the initiation of isotretinoin treatment.
  
  
  RESULTS
  We detected improvement in Beck Depression Inventory (BDI) and State and Trait Anxiety Inventory (STAI) scores in acne patients after isotretinoin therapy. Statistically significant improvement in depressive symptoms began at the first month. Improvement in anxiety was detected later than the improvement in depressive symptoms and a statistically significant difference was detected between the first and the second follow-up.
  
  
  CONCLUSIONS
  Our results provide no relationship between isotretinoin use and depression in acne patients.
authors.affiliation: Department of Dermatology, Atatürk Training and Research Hospital, Izmir, Turkey. bozdagk@gmail.com
authors.forename: Kübra Eren
authors.initials: KE
authors.lastname: Bozdağ
authors.forename: Seref
authors.initials: S
authors.lastname: Gülseren
authors.forename: Füsun
authors.initials: F
authors.lastname: Güven
authors.forename: Birmay
authors.initials: B
authors.lastname: Cam
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy* / Q000523:psychology*; D000293:Adolescent; D000328:Adult; D003866:Depressive Disorder / Q000139:chemically induced / Q000175:diagnosis / Q000453:epidemiology*; D003879:Dermatologic Agents / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015474:Isotretinoin / Q000627:therapeutic use*; D008297:Male; D011581:Psychological Tests; D055815:Young Adult
chemical_list: D003879:Dermatologic Agents; D015474:Isotretinoin