Induction of oxidative stress and lipid peroxidation in rats chronically exposed to cypermethrin through dermal application.
Present study was undertaken to study the effect of cypermethrin on oxidative stress after chronic dermal application. The insecticide was applied dermally at 50 mg/kg body weight in different groups of Wistar rats of either sex weighing 150-200 g. Significant (p < 0.05) increase in catalase activity was observed after 30 days of exposure. However, the superoxide dismutase activity declined significantly after 60 days of exposure. The activity of glutathione peroxidase and blood glutathione levels declined significantly (p < 0.05) after 30 days of cypermethrin dermal application. However, the activity of glutathione S-transferase increased significantly (p < 0.05) in all groups after 60 days of dermal exposure. Significant increase in lipid peroxidation was observed from 30 days onwards and reached a peak after 120 days of application.
Raina
Rajinder
R
Division of Pharmacology and Toxicology, Faculty of Veterinary Sciences and Animal Husbandry, Sher-e-Kashmir University of Agricultural Sciences and Technology of Jammu, R. S. Pura, Jammu-181102 (J&K), India.
Verma
Pawan K
PK
Pankaj
N K
NK
Prawez
Shahid
S
D000279:Administration, Cutaneous; D000818:Animals; D005260:Female; D005978:Glutathione / Q000097:blood; D007306:Insecticides / Q000633:toxicity*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D010088:Oxidoreductases / Q000378:metabolism; D011722:Pyrethrins / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar
D007306:Insecticides; D011722:Pyrethrins; C017160:cypermethrin; D010088:Oxidoreductases; D005978:Glutathione
Biochemistry (Mosc). 2005 Feb;70(2):200-14
15807660
Indian J Physiol Pharmacol. 1992 Apr;36(2):123-6
1506076
Neurotoxicol Teratol. 1993 Mar-Apr;15(2):71-83
8510610
Biochem Int. 1991 Mar;23(4):715-21
1651727
Toxicol Lett. 1999 Apr 12;105(3):197-205
10355540
Exp Neurol. 2003 Jan;179(1):6-8
12504862
Biochem J. 2001 Jul 1;357(Pt 1):65-72
11415437
Lancet. 2000 Jul 15;356(9225):233-41
10963212
Int J Biochem Cell Biol. 2002 Nov;34(11):1372-81
12200032
Genome. 1993 Dec;36(6):1007-14
8112568
Indian J Exp Biol. 2002 Jun;40(6):656-67
12587714
Neurochem Int. 2006 Jul;49(1):20-7
16510213
Toxicol Lett. 1999 Jun 30;107(1-3):81-7
10414784
J Pharmacol Exp Ther. 1997 May;281(2):855-60
9152394
Ann Agric Environ Med. 1998;5(2):109-16
9860811
Biochem J. 2002 Dec 1;368(Pt 2):545-53
12180906
Anal Biochem. 1979 Jun;95(2):351-8
36810
Arch Toxicol. 1988 Jan;61(3):218-23
2895627
J Neurosci. 2000 Mar 15;20(6):2094-103
10704483
Annu Rev Biochem. 1983;52:711-60
6137189
J Nutr. 1974 May;104(5):580-7
4823943
Blood. 1994 Jul 1;84(1):325-30
8018928
Lipids. 1972 Aug;7(8):518-24
5055823
J Environ Sci Health B. 1994 Sep;29(5):855-71
8089431
Biochim Biophys Acta. 1990 May 1;1044(1):158-64
2160283
J Biol Chem. 1991 Nov 15;266(32):22028-34
1657986
Food Chem Toxicol. 2001 Feb;39(2):133-9
11267706
Eur J Biochem. 1974 Sep 16;47(3):469-74
4215654
Eur J Appl Physiol. 2001 Mar;84(3):233-7
11320641
Annu Rev Biochem. 1995;64:97-112
7574505
J Biol Chem. 1974 Nov 25;249(22):7130-9
4436300
Arch Dermatol. 1990 Feb;126(2):213-21
2405780
Crit Rev Biochem Mol Biol. 1995;30(6):445-600
8770536