title: A 3 years follow-up of a Mediterranean diet rich in virgin olive oil is associated with high plasma antioxidant capacity and reduced body weight gain.
abstract: OBJECTIVE
  The aim of this study was to analyze the influence of a Mediterranean dietary pattern on plasma total antioxidant capacity (TAC) after 3 years of intervention and the associations with adiposity indexes in a randomized dietary trial (PREDIMED trial) with high cardiovascular risk patients.
  
  
  METHODS
  187 subjects were randomly selected from the PREDIMED-UNAV center after they completed 3-year intervention program. Participants were following a Mediterranean-style diet with high intake of virgin olive oil or high intake of nuts, or a conventional low-fat diet. Adiposity indexes were measured at baseline and at year 3. Plasma TAC was evaluated using a commercially available colorimetric assay kit.
  
  
  RESULTS
  Plasma TAC in the control, olive oil and nuts groups was 2.01+/-0.15, 3.51+/-0.14 and 3.02+/-0.14 mM Trolox, respectively after adjusting for age and sex. The differences between the Mediterranean diet and control groups were statistically significant (P<0.001). Moreover higher levels of TAC were significantly associated with a reduction in body weight after 3 years of intervention among subjects allocated to the virgin olive oil group (B=-1.306; 95% CI=-2.439 to -0.173; P=0.025, after adjusting for age, sex and baseline body mass index).
  
  
  CONCLUSIONS
  Mediterranean diet, especially rich in virgin olive oil, is associated with higher levels of plasma antioxidant capacity. Plasma TAC is related to a reduction in body weight after 3 years of intervention in a high cardiovascular risk population with a Mediterranean-style diet rich in virgin olive oil.
authors.affiliation: Department of Nutrition and Food Sciences, Physiology and Toxicology, University of Navarra, Navarra, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Razquin
authors.forename: J A
authors.initials: JA
authors.lastname: Martinez
authors.forename: M A
authors.initials: MA
authors.lastname: Martinez-Gonzalez
authors.forename: M T
authors.initials: MT
authors.lastname: Mitjavila
authors.forename: R
authors.initials: R
authors.lastname: Estruch
authors.forename: A
authors.initials: A
authors.lastname: Marti
mesh_terms: D000368:Aged; D000975:Antioxidants / Q000378:metabolism*; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000097:blood / Q000517:prevention & control; D004034:Diet Surveys; D018752:Diet, Fat-Restricted; D038441:Diet, Mediterranean; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009754:Nuts; D009765:Obesity / Q000097:blood / Q000517:prevention & control*; D000069463:Olive Oil; D010084:Oxidation-Reduction; D010938:Plant Oils / Q000008:administration & dosage / Q000494:pharmacology*; D012307:Risk Factors; D011795:Surveys and Questionnaires; D055105:Waist Circumference; D015430:Weight Gain
chemical_list: D000975:Antioxidants; D000069463:Olive Oil; D010938:Plant Oils