Why Aire? Compensating for late bloomers.
The question under analysis in this commentary is, what was the evolutionary selection pressure that necessitated the ectopic expression of a subset of peripheral self-antigens in the thymus and by peripheral APC? The suggestion is that antigen expression is delayed until after the immune system is responsive.
Cohn
Melvin
M
Conceptual Immunology Group, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA. cohn@salk.edu
D000818:Animals; D001324:Autoantigens / Q000276:immunology*; D006801:Humans; D007107:Immune System / Q000254:growth & development*; D017634:Self Tolerance / Q000276:immunology*; D014157:Transcription Factors / Q000276:immunology*; D000096927:AIRE Protein
D001324:Autoantigens; D014157:Transcription Factors; D000096927:AIRE Protein
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