Current available therapies and future directions in the treatment of malignant gliomas.
The prognosis of patients diagnosed with malignant glioma (MG) remains poor. However, recent advances in neuro-oncology allowing a better understanding of this particular disease have allowed the development of new therapeutics. Many molecular genetic and signal transduction pathway targets have been identified that are now being investigated. Novel locoregional treatments, as well as strategies to improve regional delivery, are being evaluated. Studies of combinations of these approaches are also underway. In this review, we will discuss the current and future therapies under evaluation for the treatment of malignant gliomas.
Desjardins
Annick
A
Preston Robert Tisch Brain Tumor Center; Department of Medicine, Duke University Medical Center, Durham, NC, USA. desja002@mc.duke.edu
Reardon
David A
DA
Vredenburgh
James J
JJ
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