title: [Emergency compatible, ABO-different blood group transfusion in the operating theater: a survey in regional Japanese Society of Anesthesiologists-certified training hospitals in 2006].
abstract: BACKGROUND
  In Japan, emergency blood transfusion practices including ABO-compatible, different blood group transfusion and uncross-matched, ABO-identical blood group transfusion are very limited possibly due to adherence to identical blood transfusion as well as fear of hemolytic reactions due to anti-A, anti-B, anti-RhD and unexpected antibodies. Purpose of the study is to examine the incidence of hemolytic reactions due to compatible, ABO-different blood group transfusion.
  
  
  METHODS
  We conducted a questionnaire survey regarding emergency compatible, different blood group transfusion in the operating theater in hospitals with more than 500 beds among those with an accredited Department of Anesthesiology regarded as regional hospitals. Of 384 institutions, 247 responded to the questionnaire. During the year 2006, compatible, ABO-different blood group transfusion was reported in 112 patients from 32 hospitals, among which 105 patients in 26 hospitals were available for further analysis.
  
  
  RESULTS
  Compatible red cell concentrate (RCC), fresh frozen plasma (FFP), and platelet concentrate (PC) were transfused in 23, 10, and 83 patients, respectively. Total amount of compatible RCC, FFP, and PC were 232, 162, and 1,679 units, respectively. In patients who were transfused with compatible RCC, two patients had unexpected antibodies. Overall mortality rate within the 30th post-operative day was 23%. In 80 patients, in whom only PCs were used as compatible blood products, blood loss was 86 +/- 85 ml x kg(-1), 65% of patients underwent cardiovascular surgery, and mortality was 11%, implying that compatible PC was transfused mainly to avoid hemorrhagic diathesis in cardiovascular patients. In 64 patients with blood type of A, B, or AB, who underwent compatible PC transfusion, type O PC, incompatible blood products, were transfused in 9 patients. In 21 patients, in whom only RCCs were used as compatible blood products, blood loss was 206 +/- 224 ml x kg(-1), and mortality was 57%. Therefore, compatible RCCs were transfused mainly to avoid life-threatening events. Uncross-matched, ABO-identical RCC transfusion was performed only in 29% of patients among these 21 patients. Transfusion-related hemolytic reactions were not reported in all 104 patients available for this analysis.
  
  
  CONCLUSIONS
  Although the patient number was small, the finding that there were no hemolytic reactions might promote emergency blood transfusion practices in Japan. High mortality rate and a low rate of uncross-matched, ABO-identical RCC transfusion in patients with compatible RCC transfusion suggest that promoting emergency blood transfusion practices might reduce mortality rate due to massive hemorrhage in the operating theater.
authors.affiliation: Office for the New Hospital Construction, Kyushu University Hospital, Fukuoka 812-8582.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Irita
authors.forename: Eiichi
authors.initials: E
authors.lastname: Inada
authors.forename: Koichi
authors.initials: K
authors.lastname: Tsuzaki
authors.forename: Shoichi
authors.initials: S
authors.lastname: Inaba
authors.forename: Makoto
authors.initials: M
authors.lastname: Handa
authors.forename: Shuichi
authors.initials: S
authors.lastname: Kino
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Mashiko
authors.forename: Takahiko
authors.initials: T
authors.lastname: Kubo
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Morita
mesh_terms: D000017:ABO Blood-Group System; D000776:Anesthesiology; D001787:Blood Group Incompatibility / Q000453:epidemiology*; D001788:Blood Grouping and Crossmatching / Q000706:statistics & numerical data*; D001803:Blood Transfusion / Q000706:statistics & numerical data*; D004630:Emergencies; D006461:Hemolysis; D006784:Hospitals, Teaching / Q000706:statistics & numerical data*; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D012955:Societies, Medical; D011795:Surveys and Questionnaires; D065227:Transfusion Reaction
chemical_list: D000017:ABO Blood-Group System