Tickets to ride: selecting cargo for clathrin-regulated internalization.
Clathrin-mediated endocytosis oversees the constitutive packaging of selected membrane cargoes into transport vesicles that fuse with early endosomes. The process is responsive to activation of signalling receptors and ion channels, promptly clearing post-translationally tagged forms of cargo off the plasma membrane. To accommodate the diverse array of transmembrane proteins that are variably gathered into forming vesicles, a dedicated sorting machinery cooperates to ensure that non-competitive uptake from the cell surface occurs within minutes. Recent structural and functional data reveal remarkable plasticity in how disparate sorting signals are recognized by cargo-selective clathrin adaptors, such as AP-2. Cargo loading also seems to govern whether coats ultimately bud or dismantle abortively at the cell surface.
Traub
Linton M
LM
Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pennsylvania 15261, USA. traub@pitt.edu
D033962:Adaptor Protein Complex 2 / Q000378:metabolism*; D000818:Animals; D002966:Clathrin / Q000378:metabolism*; D022163:Clathrin-Coated Vesicles / Q000378:metabolism*; D004705:Endocytosis / Q000502:physiology*; D006801:Humans
D033962:Adaptor Protein Complex 2; D002966:Clathrin
Biochemistry. 2009 Jun 2;48(21):4497-505
19348508
FEBS Lett. 2009 Apr 17;583(8):1337-43
19306879
Mol Biol Cell. 2008 Dec;19(12):5309-26
18843039
Traffic. 2003 Dec;4(12):885-90
14617351
Proc Natl Acad Sci U S A. 2009 Apr 21;106(16):6650-5
19363159
Traffic. 2009 Feb;10(2):186-200
19054390
Traffic. 2009 Feb;10(2):235-45
19054389
J Cell Sci. 2008 Oct 15;121(Pt 20):3445-58
18827013
EMBO J. 2006 Apr 19;25(8):1635-45
16601694
Nat Rev Mol Cell Biol. 2007 Aug;8(8):603-12
17609668
Biochemistry. 1990 Dec 4;29(48):10791-8
2125494
Nature. 2008 Dec 18;456(7224):976-979
19140243
J Virol. 2009 Jul;83(14):7117-28
19439470
J Biol Chem. 2009 Jun 5;284(23):15927-41
19359243
Nat Rev Mol Cell Biol. 2001 Mar;2(3):195-201
11265249
Mol Cell. 2009 Mar 27;33(6):775-83
19328070
Proc Natl Acad Sci U S A. 1998 Sep 15;95(19):11229-34
9736718
Mol Cell Biol. 2009 Jun;29(12):3307-18
19364824
Biochem J. 2009 Mar 15;418(3):701-15
19000037
Cell. 2005 May 20;121(4):593-606
15907472
Mol Cell. 2005 May 27;18(5):519-31
15916959
Trends Cell Biol. 2004 Apr;14(4):167-74
15066634
Annu Rev Pharmacol Toxicol. 2008;48:601-29
17995450
Mol Biol Cell. 2006 Dec;17(12):5298-308
17035630
J Cell Biol. 2003 Oct 27;163(2):231-6
14581451
BMC Evol Biol. 2008 Jul 29;8:222
18664266
J Cell Sci. 1999 May;112 ( Pt 9):1375-83
10194416
EMBO J. 2005 Jul 6;24(13):2414-24
15933713
Annu Rev Cell Dev Biol. 2003;19:141-72
14570567
Cell Microbiol. 2008 May;10(5):1040-57
18076669
J Cell Biol. 2002 Feb 18;156(4):665-76
11839771
Exp Cell Res. 2009 May 15;315(9):1574-83
19070615
Mol Cell. 1998 Jan;1(2):193-202
9659916
Mol Biol Cell. 2006 Oct;17(10):4300-17
16870701
J Biol Chem. 2001 May 25;276(21):18000-6
11279214
J Biol Chem. 1998 Jul 3;273(27):17056-63
9642270
Am J Physiol Cell Physiol. 2006 Nov;291(5):C1072-81
17035303
Cell. 1999 Oct 15;99(2):179-88
10535736
J Biol Chem. 2006 Jun 9;281(23):16139-46
16537543
Cell Microbiol. 2008 Dec;10(12):2553-67
18754852
Mol Cell. 2006 Mar 17;21(6):737-48
16543144
Dev Cell. 2007 Jan;12(1):129-41
17199046
Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10283-10288
16801533
J Neurosci. 2006 Aug 2;26(31):8195-205
16885233
PLoS Biol. 2009 Mar 17;7(3):e57
19296720
Nat Cell Biol. 2007 Jan;9(1):113-20
17173037
Mol Cells. 2000 Jun 30;10(3):309-16
10901169
Cell. 2008 Sep 5;134(5):817-27
18775314
J Cell Sci. 2009 May 1;122(Pt 9):1301-5
19351721
J Cell Sci. 2006 Oct 15;119(Pt 20):4235-46
16984970
Mol Cell. 2005 Oct 28;20(2):301-12
16246731
J Cell Biol. 2008 Feb 11;180(3):467-72
18250197
Mol Biol Cell. 2005 Apr;16(4):1769-76
15689492
Dev Cell. 2007 Jul;13(1):15-28
17609107
Mol Biol Cell. 1999 Mar;10(3):677-91
10069811
J Biol Chem. 2003 Oct 31;278(44):43411-7
12900408
J Biol Chem. 2002 Feb 1;277(5):3552-9
11602587
Curr Biol. 2001 Jun 5;11(11):896-900
11516654
EMBO J. 2008 Oct 8;27(19):2457-70
18784754
PLoS Biol. 2006 Sep;4(9):e262
16903783
EMBO J. 1999 May 4;18(9):2489-99
10228163
J Cell Biol. 2007 Jun 4;177(5):905-16
17535965
EMBO Rep. 2008 Dec;9(12):1216-21
18953286
Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3616-21
18305175
Mol Biol Cell. 1999 Nov;10(11):3643-59
10564262
EMBO J. 2009 Aug 19;28(16):2461-8
19536136
Traffic. 2009 Jul;10(7):938-50
19416476
J Biol Chem. 2008 Aug 1;283(31):21453-61
18539600
J Cell Biol. 2003 Sep 1;162(5):909-18
12952941
Cell Signal. 2006 Oct;18(10):1560-71
16725309
Hum Mol Genet. 2007 Nov 15;16(22):2751-9
17761685
J Cell Biol. 2002 Mar 4;156(5):791-5
11877457
Cell. 2005 Sep 9;122(5):735-49
16143105
Nature. 2006 May 25;441(7092):528-31
16648839
Science. 1995 Sep 29;269(5232):1872-5
7569928
Proc Natl Acad Sci U S A. 2006 Jun 6;103(23):8715-20
16735469
Traffic. 2001 Feb;2(2):105-10
11247301
Cell. 2008 Nov 14;135(4):714-25
18976803
Traffic. 2008 Sep;9(10):1791-800
18657069
Nature. 2008 Jan 24;451(7177):425-30
18200009
Cell. 2004 Sep 3;118(5):591-605
15339664
Traffic. 2006 Mar;7(3):282-97
16497223
Annu Rev Biochem. 2003;72:395-447
12651740
FEBS Lett. 2006 Oct 16;580(24):5797-801
17022975
J Virol. 2008 Feb;82(3):1166-74
18032517
Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):16904-9
17940017
J Cell Biol. 1996 Oct;135(2):341-54
8896593
Nature. 2007 Aug 23;448(7156):883-8
17713526
J Virol. 2008 Apr;82(7):3181-91
18216114
Annu Rev Cell Dev Biol. 2004;20:153-91
15473838
Science. 1998 Nov 13;282(5392):1327-32
9812899
J Biol Chem. 2008 Dec 5;283(49):34365-73
18819912
Traffic. 2007 Jul;8(7):914-31
17547696
Mol Biol Cell. 1998 May;9(5):1177-94
9571248
Cell Metab. 2008 Jun;7(6):508-19
18522832
Nat Rev Mol Cell Biol. 2003 Mar;4(3):202-12
12612639
Nat Rev Mol Cell Biol. 2009 Apr;10(4):287-92
19277045
Mol Biol Cell. 2004 Dec;15(12):5306-17
15385627
J Biol Chem. 2003 Nov 14;278(46):45160-70
12960147
J Cell Biol. 2007 Dec 3;179(5):935-50
18056411
EMBO J. 1997 Oct 1;16(19):5847-54
9312043
J Virol. 2009 Mar;83(6):2518-30
19129443
Traffic. 2001 Feb;2(2):111-23
11247302
Biochemistry. 2002 Mar 12;41(10):3321-8
11876640
Nat Rev Mol Cell Biol. 2002 Dec;3(12):971-7
12461563
Nat Cell Biol. 2002 May;4(5):389-93
11988742
J Cell Sci. 2007 Nov 1;120(Pt 21):3850-8
17940069
Traffic. 2006 Mar;7(3):262-81
16497222
EMBO J. 2009 Feb 18;28(4):359-71
19153599
J Biol Chem. 2004 Mar 26;279(13):13190-204
14722064
J Biol Chem. 2009 Jul 17;284(29):19228-36
19433580
Biochem Soc Trans. 2008 Oct;36(Pt 5):791-6
18793138
Mol Cell Biol. 2005 Nov;25(21):9318-23
16227583
Cell Mol Life Sci. 2009 Jul;66(13):2049-65
19290477
Biochem Biophys Res Commun. 2009 Feb 20;379(4):909-13
19138666
J Biol Chem. 2006 Dec 1;281(48):36724-31
17028178
EMBO J. 1999 Jul 15;18(14):3897-908
10406795
Trends Cell Biol. 2006 Oct;16(10):505-13
16935508
J Biol Chem. 2003 Mar 21;278(12):10737-43
12529323
Cell. 2006 Mar 10;124(5):997-1009
16530046
J Biol Chem. 2008 Mar 7;283(10):5973-84
18180291
J Cell Biol. 2002 Mar 4;156(5):921-9
11877461
J Cell Biol. 2003 Dec 22;163(6):1281-90
14691137
J Biol Chem. 2004 Apr 16;279(16):16657-61
14985334
Dev Cell. 2006 Mar;10(3):329-42
16516836
Development. 2004 Nov;131(21):5367-80
15469974
EMBO J. 1988 Nov;7(11):3331-6
2905261
J Cell Biol. 2008 Nov 3;183(3):499-511
18981233
Cell. 2006 Oct 6;127(1):113-24
17018281
Mol Biol Cell. 2008 Mar;19(3):1252-60
18199683
J Cell Sci. 2005 Jul 15;118(Pt 14):3073-80
15985462
Cell. 2002 May 17;109(4):523-35
12086608
J Cell Biol. 2009 Jul 13;186(1):99-111
19581412
Cell. 2007 Jan 12;128(1):171-82
17218263
J Cell Biol. 2007 Dec 31;179(7):1497-510
18166656
Cell. 2005 Dec 2;123(5):875-88
16325581
Traffic. 2006 Oct;7(10):1420-31
16899088