Genetics: breast cancer as an exemplar.
Genetic testing for adult-onset diseases is now available. One such test is for the mutations present in the BRCA gene that result in a significantly higher risk for the development of breast cancer or ovarian cancer. Women who have one of these mutations face difficult choices in terms of increased surveillance or prophylactic surgeries. Examining experiences of women with BRCA mutations can serve as an exemplar for other populations at risk for genetically associated adult-onset diseases.
Hamilton
Rebekah
R
Department of Women, Children and Family Health Science, College of Nursing, University of Illinois at Chicago, Chicago, IL 60612, USA. hamilr@uic.edu
D000223:Adaptation, Psychological; D000328:Adult; D001294:Attitude to Health; D001943:Breast Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000517:prevention & control; D005260:Female; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D005817:Genetic Counseling; D020022:Genetic Predisposition to Disease / Q000235:genetics / Q000517:prevention & control; D005820:Genetic Testing / Q000379:methods / Q000523:psychology; D006801:Humans; D008408:Mastectomy; D009154:Mutation / Q000235:genetics; D009386:Neoplastic Syndromes, Hereditary / Q000175:diagnosis / Q000235:genetics / Q000517:prevention & control; D024802:Nurse's Role; D010052:Ovariectomy; D010375:Pedigree; D017410:Practice Guidelines as Topic; D012017:Referral and Consultation; D018570:Risk Assessment; D040242:Risk Reduction Behavior; D016387:Women's Health
Nurs Sci Q. 2007 Jul;20(3):254-64
17595406
J Genet Couns. 2009 Oct;18(5):418-35
19479365
Psychooncology. 2008 Aug;17(8):767-73
17992698
J Genet Couns. 2008 Aug;17(4):314-26
18481164
Br J Cancer. 2006 Mar 27;94(6):814-9
16495917
N Engl J Med. 2002 May 23;346(21):1609-15
12023992
Am J Hum Genet. 2003 May;72(5):1117-30
12677558
Psychooncology. 2001 May-Jun;10(3):231-41
11351375
Fam Cancer. 2005;4(2):121-6
15951962
Clin Genet. 2006 Dec;70(6):462-72
17100990
Patient Educ Couns. 2001 Mar;42(3):213-24
11164320
Clin Breast Cancer. 2007 Dec;7(11):875-82
18269778
Prev Med. 2002 Oct;35(4):343-8
12453711
Sociol Health Illn. 2006 Nov;28(7):969-88
17163862
Fam Cancer. 2005;4(2):163-7
15951968
Genet Test. 2004 Fall;8(3):235-9
15727245
Soc Sci Med. 2004 Aug;59(3):553-65
15144764
Clin Genet. 2003 Oct;64(4):317-26
12974737
Qual Health Res. 2006 Jan;16(1):97-118
16317179
N Engl J Med. 2002 May 23;346(21):1616-22
12023993
J Clin Oncol. 2007 Apr 10;25(11):1329-33
17416853
Sociol Health Illn. 2003 Nov;25(7):838-65
19774749
N Engl J Med. 1999 Jul 1;341(1):28-37
10387940
J Womens Health. 1997 Jun;6(3):317-27
9201666
Am J Med Genet A. 2003 Jun 15;119A(3):340-7
12784302
Mil Med. 2002 Feb;167(2):93-8
11873549
Genet Test. 2004 Summer;8(2):148-56
15345112
Cell. 2002 Jan 25;108(2):171-82
11832208
N Engl J Med. 2004 Jul 29;351(5):427-37
15282350
N Engl J Med. 2003 Jun 5;348(23):2339-47
12788999
Res Theory Nurs Pract. 2003 Winter;17(4):339-52
14960000
Psychooncology. 2000 Nov-Dec;9(6):496-503
11180584
J Genet Couns. 2009 Apr;18(2):147-59
18979190
J Genet Couns. 2005 Oct;14(5):349-63
16195942
Health Commun. 2006;19(2):115-23
16548702
Psychooncology. 2007 Apr;16(4):320-8
16909428
Psychooncology. 2008 Aug;17(8):756-66
18613300
J Clin Oncol. 2003 Oct 15;21(20):3867-74
14551306
Psychooncology. 2008 Aug;17(8):797-803
18646247
Am J Med Genet C Semin Med Genet. 2003 May 15;119C(1):78-86
12704641
J Med Ethics. 2003 Apr;29(2):74-9; discussion 80-3
12672886
J Natl Cancer Inst Monogr. 2005;(34):83-6
15784831
Psychooncology. 2009 Oct;18(10):1088-96
19214961
J Nurs Scholarsh. 2005;37(1):18-24
15813582
Nature. 1995 Dec 21-28;378(6559):789-92
8524414
Prev Med. 2000 Jul;31(1):75-80
10896846
Genet Test. 2002 Winter;6(4):291-302
12537653
J Nurs Scholarsh. 2009;41(3):276-83
19723276
J Natl Compr Canc Netw. 2021 Jan 06;19(1):77-102
33406487
Psychooncology. 2005 Dec;14(12):1060-74
15937976
Nurs Ethics. 2000 May;7(3):237-49
10986947
Br J Cancer. 1996 Aug;74(3):482-7
8695370
Ann N Y Acad Sci. 1999 Jun 30;882:42-55; discussion 56-65
10415885
Community Genet. 2004;7(1):15-24
15475667
Science. 1994 Oct 7;266(5182):66-71
7545954
J Genet Couns. 2006 Jun;15(3):149-62
16724273
Nat Med. 2001 May;7(5):552-6
11329055
Science. 2003 Oct 24;302(5645):643-6
14576434
Prev Med. 2004 Apr;38(4):388-402
15020172