[Monitoring precursor chemicals through enantiomer profiling of methamphetamine].
OBJECTIVE
The enantiomer profiling of methamphetamine is can be utilized for regulation of the precursors, investigatin of the drug case.


METHODS
In the present study, we investigated on the enantiomer of 114 crystalline methamphetamine samples seized in Beijing, Tianjin, Shijiazhuang and Chengdu. The methamphetamine samples were derivatized with (S)-(+)-a-methoxya-(trifluoromethyl)phenylacetyl chloride ((S)-(+)-MTPACl), and the derivatives were analyzed by GC-MS in selected ion monitoring (SIM) mode.


RESULTS
Most of the seizures were pure S (+)-enantiomer (90.4%), but 3.5% (4 of 114 samples) contained R(-)-enantiomer above 1%.


CONCLUSIONS
This indicates that the majority of samples were prepared from either (1R, 2S)-(-)-ephedrine or (1S, 2S)-(+)-pseudoephedrine. At the same time, there were methamphetamine drugs synthesized from (1S, 2R)-(-)-ephedrine or (1R, 2R)-(+)-pseudoephedrine.
Zhang
Jianxin
J
Forensic Medical Examination Center of Beijing Public Security Bureau, Beijing 100085, China. zhangjianxin7292000@yahoo.com.cn
Zhang
Daming
D
Zhang
Wenfang
W
Qiao
Jing
J
D004809:Ephedrine / Q000737:chemistry*; D008401:Gas Chromatography-Mass Spectrometry; D008694:Methamphetamine / Q000138:chemical synthesis* / Q000737:chemistry*; D011355:Prodrugs / Q000737:chemistry*; D054199:Pseudoephedrine / Q000737:chemistry*; D013237:Stereoisomerism
D011355:Prodrugs; D008694:Methamphetamine; D054199:Pseudoephedrine; D004809:Ephedrine