title: Measuring the combinatorial expression of solute transporters and metalloproteinases transcripts in colorectal cancer.
abstract: BACKGROUND
  It was hypothesised that colorectal cancer (CRC) could be diagnosed in biopsies by measuring the combined expression of a small set of well known genes. Genes were chosen based on their role in either the breakdown of the extracellular matrix or with changes in cellular metabolism both of which are associated with CRC progression
  
  
  RESULTS
  Gene expression data derived from quantitative real-time PCR for the solute transporter carriers (SLCs) and the invasion-mediating matrix metalloproteinases (MMPs) were examined using a Linear Descriminant Analysis (LDA). The combination of MMP-7 and SLC5A8 was found to be the most predictive of CRC.
  
  
  CONCLUSIONS
  A combinatorial analysis technique is an effective method for both furthering our understanding on the molecular basis of some aspects of CRC, as well as for leveraging well defined cancer-related gene sets to identify cancer. In this instance, the combination of MMP-7 and SLC5A8 were optimal for identifying CRC.
authors.affiliation: CSIRO Preventative Health Flagship, CSIRO Division of Molecular and Health Technologies, CSIRO, Division of Molecular and Health Technologies, Adelaide, SA, 5000, Australia . Caroline.Kerr@csiro.au
authors.forename: Caroline A
authors.initials: CA
authors.lastname: Kerr
authors.forename: Robert
authors.initials: R
authors.lastname: Dunne
authors.forename: Barney M
authors.initials: BM
authors.lastname: Hines
authors.forename: Michelle
authors.initials: M
authors.lastname: Zucker
authors.forename: Leah
authors.initials: L
authors.lastname: Cosgrove
authors.forename: Andrew
authors.initials: A
authors.lastname: Ruszkiewicz
authors.forename: Trevor
authors.initials: T
authors.lastname: Lockett
authors.forename: Richard
authors.initials: R
authors.lastname: Head
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