Influence of conditioned reinforcement on the response-maintaining effects of quinpirole in rats.
D2-like agonists, such as quinpirole, maintain responding in monkeys, rats, and mice when they are substituted for cocaine. This study examined the influence of operant history and cocaine-paired stimuli (CS) on quinpirole-maintained responding in rats trained to nose poke for cocaine. Upon acquisition of responding for cocaine, substitutions were performed in the presence or absence of injection-CS pairings. Although cocaine maintained responding regardless of whether injections were accompanied by CS, quinpirole maintained responding only when CS were paired with injections. To assess the influence of operant history, injections of cocaine, quinpirole, remifentanil, nicotine, or saline were made available on a previously inactive lever, while nose pokes continued to result in CS presentation. Although responding was reallocated from the nose poke to the lever when cocaine or remifentanil was available, lever presses remained low, and nose poking persisted when quinpirole or nicotine was made contingent upon lever presses. Finally, quinpirole pretreatments resulted in high rates of nose poking when nose pokes resulted in CS presentation alone, but failed to maintain nose poking when the CS was omitted. Taken together, these results suggest that the response-maintaining effects of quinpirole are primarily mediated by an enhancement of the conditioned reinforcing effects of earlier CS, rather than by a reinforcing effect of quinpirole.
Collins
Gregory T
GT
Department of Pharmacology, University of Michigan Medical School, Michigan, USA. collinsg@umich.edu
Woods
James H
JH
D000704:Analysis of Variance; D000818:Animals; D029681:Arabidopsis Proteins; D001522:Behavior, Animal / Q000187:drug effects; D003042:Cocaine / Q000008:administration & dosage; D003214:Conditioning, Classical / Q000187:drug effects; D003216:Conditioning, Operant / Q000187:drug effects*; D003213:Conditioning, Psychological / Q000187:drug effects; D018491:Dopamine Agonists / Q000494:pharmacology*; D018765:Dopamine Uptake Inhibitors / Q000008:administration & dosage; D008297:Male; D009687:Nuclear Proteins; D019257:Quinpirole / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012055:Reinforcement Schedule; D012054:Reinforcement, Psychology; D012646:Self Administration
D029681:Arabidopsis Proteins; D018491:Dopamine Agonists; D018765:Dopamine Uptake Inhibitors; D009687:Nuclear Proteins; C523534:TIC protein, Arabidopsis; D019257:Quinpirole; D003042:Cocaine
Behav Brain Res. 2006 May 15;169(2):320-4
16527365
Behav Neurosci. 1998 Dec;112(6):1475-85
9926830
J Exp Anal Behav. 2007 May;87(3):409-21
17575906
Nature. 1976 Nov 4;264(5581):57-9
12471
Neuroimage. 2004 Apr;21(4):1790-7
15050599
J Pharmacol Exp Ther. 1984 Sep;230(3):678-83
6332190
CNS Drugs. 2009;23(2):157-70
19173374
Behav Neurosci. 2003 Oct;117(5):952-60
14570545
Neuropsychopharmacology. 2003 Feb;28(2):329-38
12589386
J Med Chem. 2005 Jun 2;48(11):3663-79
15916415
Philos Trans R Soc Lond B Biol Sci. 2008 Oct 12;363(1507):3191-200
18640912
Philos Trans R Soc Lond B Biol Sci. 2008 Oct 12;363(1507):3125-35
18640910
Addict Biol. 2007 Mar;12(1):35-50
17407496
Drug Alcohol Depend. 1999 Apr 1;54(2):97-110
10217549
Psychopharmacology (Berl). 1996 May;125(1):13-22
8724444
Behav Brain Res. 2006 Sep 15;172(1):1-13
16677719
J Pharmacol Exp Ther. 1981 Jul;218(1):271-81
7241384
Drug Alcohol Depend. 2006 Jan 4;81(1):63-70
16005579
J Exp Anal Behav. 2008 May;89(3):263-98
18540215
Behav Neurosci. 2001 Oct;115(5):1086-92
11584921
Neurology. 2006 Oct 10;67(7):1254-7
16957130
Behav Neurosci. 2001 Dec;115(6):1291-300
11770060
Science. 1993 Jun 18;260(5115):1814-6
8099761
Am J Psychiatry. 1999 Sep;156(9):1440-3
10484959
J Neurol. 2008 Sep;255 Suppl 5:48-56
18787882
J Pharmacol Exp Ther. 2007 Nov;323(2):599-605
17675585
Psychopharmacology (Berl). 2006 Nov;189(1):27-36
17019569
J Pharmacol Exp Ther. 2006 Jun;317(3):1088-96
16478825
Psychopharmacology (Berl). 2004 Oct;176(1):101-8
15071719
Nat Neurosci. 2002 Feb;5(2):169-74
11802171
Arch Neurol. 2006 Jul;63(7):969-73
16831966
Psychopharmacology (Berl). 1993;110(3):355-64
7831431
Behav Brain Res. 2004 Nov 5;155(1):117-24
15325785
J Neurosci. 2002 Apr 1;22(7):2977-88
11923462
Clin Neuropharmacol. 2007 Sep-Oct;30(5):249-55
17909302
Philos Trans R Soc Lond B Biol Sci. 2008 Oct 12;363(1507):3181-9
18640909
Synapse. 2005 Jul;57(1):17-28
15858839
Arch Gen Psychiatry. 2003 Aug;60(8):828-36
12912766
Biol Psychiatry. 2005 Nov 15;58(10):787-95
15993856
Neurology. 2003 Aug 12;61(3):422-3
12913220
Drug Alcohol Depend. 2007 Jun 15;89(1):52-9
17240084
Physiol Behav. 2003 Oct;80(1):1-7
14568302
Psychopharmacology (Berl). 2002 Sep;163(2):230-7
12202970
Ann Neurol. 2008 Dec;64 Suppl 2:S93-100
19127573
J Gambl Stud. 2009 Sep;25(3):425-31
19241148
Nature. 1999 Jul 22;400(6742):371-5
10432116
Science. 2007 Mar 2;315(5816):1267-70
17332411
Psychopharmacology (Berl). 2000 Dec;153(1):17-30
11255926
Learn Behav. 2004 Nov;32(4):463-76
15825887
Psychopharmacology (Berl). 2003 Aug;169(1):68-76
12774186
Int J Neuropsychopharmacol. 2007 Apr;10(2):167-81
16426478
Psychopharmacology (Berl). 1992;107(4):523-9
1603895
Brain Res Brain Res Rev. 2005 Jul;49(1):77-105
15960988
Arch Neurol. 2007 Aug;64(8):1089-96
17698698
Br J Pharmacol. 1981 Sep;74(1):149-54
6115694
Psychopharmacology (Berl). 2001 Apr;154(4):390-6
11349392
Behav Brain Res. 2006 May 15;169(2):303-11
16524632