[Unsual clinical signs of primary hyperparathroidism].
BACKGROUND
A growing number of patients with primary hyperparathyroidism (PHPT) are diagnosed in the absence of symptoms following routine biochemical screening. However, in some countries, overt manifestations and osteitis fibrosa cystica (OFC) still dominate the clinical profile of PHPT patients.


METHODS
We retrospectively studied clinical and biochemical manifestations of 47 consecutive patients with primary hyperparathyroidism who were treated with parathyroidectomy from October 1993 to June 2005.


RESULTS
Mean age was of 51.3 years. Our sample included 40 women (85%) and 7 men (15%). Seventy eight percent of cases had radiological features of OFC, namely subperiosteal bone resorption, cortical cysts and osteopenia. Pathological fracture occurred in nine patients (19.1%). Fifteen (32%) patients had clinically evident bony deformities or brown tumors mostly located in the mandible and maxilla.


CONCLUSIONS
Our results indicate that symptomatic osteitis fibrosa cystica and severe decrease of bone mineral density were the primary manifestations of primary hyperparathyroidism. Most patients were referred to an oncology hospital for treatment due to a suspected malignant neoplasm. A comprehensive clinical evaluation with biochemical markers, imaging studies and histological results is needed to establish a possible diagnosis of primary hyperparathyroidism.
Reséndiz-Colosia
Jaime Alonso
JA
Servicio de Tumores de Cabeza, Cuello y Piel, Hospital de Oncologla, Centro Médico Nacional SigloXXI, Instituto Mexicano del Seguro Social, México D.F., México. resendizjaime@aol.com
Rodriguez-Cuevas
Sergio Arturo
SA
Medrano-Ortiz de Zarate
María Elena
ME
Flores-Díaz
Rutilio
R
Gallegos-Hernández
José Francisco
JF
Gómez-Acosta
Fernando
F
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D049950:Hyperparathyroidism, Primary / Q000150:complications / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies