Peripheral blood stem cell collection in elderly patients.
Intensive treatments like autologous blood stem cell transplantations are standard consolidation treatments for lymphoma and myeloma in young people. The upper age limit for these procedures is constantly increasing. Instead of studying the impact of aging on harvesting peripheral blood stem cells (PBSC), we performed a retrospective study to explore the feasibility of collecting stem cells from patients older than 65 years and compared the efficacy to harvest in younger patients. During a period of 7 years, we identified 108 patients with myeloma or lymphoma who were older than 65 years who underwent PBSC collection. Only eight patients failed to produce a successful harvest. The majority of patients only needed one apheresis (71%). There was a median number of 5.3 x 10(6) CD34+ cells/kg. Our study demonstrated that older patients can also undergo PBSC harvests similar to younger patients.
Tempescul
Adrian
A
Department of Clinical Haematology, Institute of Cancerology and Hematology, CHU Morvan, 29609 Brest, France. tempescul@hotmail.com
Ianotto
Jean-Christophe
JC
Hardy
Elisabeth
E
Quivoron
Francoise
F
Petrov
Ljubomir
L
Berthou
Christian
C
D000367:Age Factors; D000368:Aged; D018952:Antigens, CD34; D001781:Blood Component Removal / Q000379:methods* / Q000592:standards; D002452:Cell Count; D005240:Feasibility Studies; D019650:Hematopoietic Stem Cell Mobilization; D006801:Humans; D008223:Lymphoma / Q000628:therapy; D009101:Multiple Myeloma / Q000628:therapy; D036102:Peripheral Blood Stem Cell Transplantation / Q000379:methods; D012189:Retrospective Studies
D018952:Antigens, CD34