title: A novel uni-acupoint electroacupuncture stimulation method for pain relief.
abstract: Electroacupuncture stimulation (EAS) has been demonstrated effective for pain relief and treating other various diseases. However, the conventional way of EAS, the bi-acupoint method, is not suitable for basis study of acupoint specificity. Moreover, its operations are inconvenient and difficult to be persevered, especially for long-term, continuous and even imperative treatments. These disadvantages motivate designs of new EAS methods. We present a novel uni-acupoint electrical stimulation method, which is applied at a single acupoint and quite meets the needs of basis study and simpler clinical application. Its pain relief effect has been evaluated by animal tests of Wistar rats. During the experiments, rats were given 30 min 2/100 Hz uni- and bi-acupoint EAS and their nociceptive thresholds before and after EAS were attained by hot-plate test. The analgesic effect was defined as the change of nociceptive threshold and used to evaluate the effectiveness of uni-acupoint EAS for pain relief. The hot-plate test results indicated that analgesic effect of uni-acupoint group was significantly higher than that of the control group and there was no significant difference of analgesic effects between uni- and bi-acupoint EAS. The results suggested that uni-acupoint method was an effective EAS method and had comparable pain relief effect with bi-acupoint method.
authors.affiliation: Department of Mechanical Engineering, Tsinghua University, Beijing, China.
authors.forename: Chuansen
authors.initials: C
authors.lastname: Niu
authors.forename: Hongwei
authors.initials: H
authors.lastname: Hao
authors.forename: Jun
authors.initials: J
authors.lastname: Lu
authors.forename: Luming
authors.initials: L
authors.lastname: Li
authors.forename: Zhirong
authors.initials: Z
authors.lastname: Han
authors.forename: Ya
authors.initials: Y
authors.lastname: Tu
references.citation: Brain Res. 1999 Dec 18;851(1-2):290-6
references.pmid: 10642860
references.citation: Brain Res. 2005 May 24;1044(2):155-63
references.pmid: 15885214
references.citation: Evid Based Complement Alternat Med. 2008 Sep;5(3):257-66
references.pmid: 18830420
references.citation: Pain. 2006 May;122(1-2):81-9
references.pmid: 16527396
references.citation: Neurosci Lett. 2004 May 6;361(1-3):258-61
references.pmid: 15135942
references.citation: NIH Consens Statement. 1997 Nov 3-5;15(5):1-34
references.pmid: 10228456
references.citation: Hum Psychopharmacol. 2002 Oct;17(7):345-8
references.pmid: 12415553
references.citation: Pain. 2001 Mar;91(1-2):5-13
references.pmid: 11240073
references.citation: Neuroimage. 2002 Aug;16(4):1028-37
references.pmid: 12202090
references.citation: Pain. 2004 Jun;109(3):299-307
references.pmid: 15157691
references.citation: JAMA. 1999 Mar 3;281(9):818-23
references.pmid: 10071003
references.citation: Neurochem Res. 2008 Oct;33(10):2107-11
references.pmid: 18461444
references.citation: Acta Histochem. 2005;107(1):67-76
references.pmid: 15866287
references.citation: Nature. 1999 Apr 29;398(6730):805-10
references.pmid: 10235262
references.citation: Evid Based Complement Alternat Med. 2007 Mar;4(1):125-30
references.pmid: 17342250
references.citation: Neurosci Lett. 2004 Jan 2;354(1):50-3
references.pmid: 14698480
references.citation: Neurosci Lett. 2001 Jul 13;307(2):105-8
references.pmid: 11427311
references.citation: Biol Psychiatry. 1998 Jul 15;44(2):129-38
references.pmid: 9646895
references.citation: Pain. 2002 Oct;99(3):509-514
references.pmid: 12406527
references.citation: Trends Neurosci. 2003 Jan;26(1):17-22
references.pmid: 12495858
references.citation: Med Eng Phys. 2003 Apr;25(3):239-53
references.pmid: 12589722
references.citation: Int J Neurosci. 2006 Feb;116(2):115-25
references.pmid: 16393878
references.citation: Exp Neurol. 2005 Mar;192(1):156-62
references.pmid: 15698629