Effect of dietary cadmium on lipid metabolism and storage of aquatic bird Cairina moschata.
In environment, birds often fast in connection with breeding, migration or drastic climatic conditions and need to mobilize lipid reserves during these periods. The impairment of lipid metabolism by cadmium (Cd; 1 mg kg(-1) added in diet) was investigated on palmiped Cairina moschata. Expression levels of genes involved in lipid metabolism, mitochondrial metabolism and detoxification were investigated in liver and muscle of ducks. Lipid content in muscle and liver were analysed and plasma triglycerides were quantified. After 20 days, ducks exposed to Cd displayed a lower body weight and lower lipid content in liver than controls. In muscle, the increase of lipid content was only significant for control ducks but not for exposed ducks. Exposed ducks appeared unable to sufficiently transport and store lipids into peripheral tissues. Cd impairs lipid metabolism by several ways. First, Cd triggered the down-regulation of fatty acids synthesis in liver even if the NADPH production and the mitochondrial metabolism are enhanced, suggesting a stronger energy needs. Secondly, the associated decrease of plasma triglycerides and lipoprotein lipase activity with Cd are consistent with impairment of lipids storage in peripheral tissues.
Lucia
Magali
M
IPREM-EEM (Institut Pluridisciplinaire de Recherche sur l'Environnement et les Matériaux, Equipe Environnement et Microbiologie), UMR 5254, IUT des Pays de l'Adour, BP 201, 40004 Mont de Marsan Cedex, France. magali.lucia@etud.univ-pau.fr
André
Jean-Marc
JM
Gonzalez
Patrice
P
Baudrimont
Magalie
M
Bernadet
Marie-Dominique
MD
Gontier
Karine
K
Maury-Brachet
Régine
R
Guy
Gérard
G
Davail
Stéphane
S
D000818:Animals; D001483:Base Sequence; D001835:Body Weight / Q000187:drug effects; D002104:Cadmium / Q000378:metabolism / Q000633:toxicity*; D017931:DNA Primers / Q000235:genetics; D004372:Ducks / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000187:drug effects*; D005941:Glucokinase / Q000235:genetics / Q000378:metabolism; D008049:Lipase / Q000235:genetics / Q000378:metabolism; D050356:Lipid Metabolism / Q000187:drug effects*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008291:Malate Dehydrogenase / Q000235:genetics / Q000378:metabolism; D008297:Male; D008969:Molecular Sequence Data; D018482:Muscle, Skeletal / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D017422:Sequence Analysis, DNA; D018709:Statistics, Nonparametric
D017931:DNA Primers; D002104:Cadmium; D008291:Malate Dehydrogenase; D005941:Glucokinase; D008049:Lipase
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