title: Neurod1 is essential for the survival and maturation of adult-born neurons.
abstract: The transcriptional program that controls adult neurogenesis is unknown. We generated mice with an inducible stem cell-specific deletion of Neurod1, resulting in substantially fewer newborn neurons in the hippocampus and olfactory bulb. Thus, Neurod1 is cell-intrinsically required for the survival and maturation of adult-born neurons.
authors.affiliation: Department of Molecular Biology and Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
authors.forename: Zhengliang
authors.initials: Z
authors.lastname: Gao
authors.forename: Kerstin
authors.initials: K
authors.lastname: Ure
authors.forename: Jessica L
authors.initials: JL
authors.lastname: Ables
authors.forename: Diane C
authors.initials: DC
authors.lastname: Lagace
authors.forename: Klaus-Armin
authors.initials: KA
authors.lastname: Nave
authors.forename: Sandra
authors.initials: S
authors.lastname: Goebbels
authors.forename: Amelia J
authors.initials: AJ
authors.lastname: Eisch
authors.forename: Jenny
authors.initials: J
authors.lastname: Hsieh
mesh_terms: D053687:Adult Stem Cells / Q000502:physiology*; D000818:Animals; D001253:Astrocytes / Q000502:physiology; D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics / Q000378:metabolism*; D002454:Cell Differentiation / Q000502:physiology; D002470:Cell Survival / Q000502:physiology; D002478:Cells, Cultured; D006624:Hippocampus / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D055495:Neurogenesis / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D009830:Olfactory Bulb / Q000502:physiology*; D013997:Time Factors
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; C501008:Neurod1 protein, mouse
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