Autoantibodies in silicosis patients and in silica-exposed individuals.
The aim of this study was to evaluate the prevalence of autoantibodies in silica-exposed patients with and without silicosis and without any known rheumatic disease. We studied 61 males exposed to silica for a mean time of 12.2 +/- 10.2 years of exposure. A total of 72.1% (44/61) of them presented with pulmonary silicosis. As control group we included 62 healthy males. In all samples we screened for rheumatoid factor (latex agglutination), antinuclear antibodies (indirect immunofluorescence), anti Scl-70 (ELISA) and ANCA (indirect immunofluorescence technique). One patient (1.6%) of the silica group had weakly positive ANA (titer 1:80, centromeric pattern); one (1.6%) had atypical ANCA and seven patients (11.4%) presented positive rheumatoid factor (values range from 8 to 32 UI/ml). One control patient had a positive RF and none of them had positive ANA or ANCA. All patients and controls were negative for anti-Scl-70. The finding of positive RF was higher in the silica-exposed patients (p = 0.032; Fisher). All patients with positive RF had pulmonary silicosis. In the silica-exposed group we could not find a relationship between the presence of RF and age (p = 0.21; Mann-Whitney), smoking habits (p = 0.25; Fisher) but a positive relationship was found with exposure time to silica dust (p = 0.005; Mann-Whitney). We conclude that there was 11.4% prevalence of low titer RF in the silica-exposed patients without known rheumatic disease. RF was more common in patients with longer exposure to silica dust and appeared only in those with silicosis. The presence of ANA, Scl-70 and ANCA was the same as in the control population.
Zaghi
Gabriel
G
Rheumatology Unit, Curitiba's Evangelic University Hospital, Rua João Alencar Guimarães, 796, Curitiba, PR, 80310420, Brazil.
Koga
Fábio
F
Nisihara
Renato M
RM
Skare
Thelma L
TL
Handar
Antonieta
A
Rosa Utiyama
Shirley R
SR
Silva
Marilia Barreto
MB
D000328:Adult; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000096:biosynthesis / Q000097:blood; D000974:Antibodies, Antinuclear / Q000096:biosynthesis / Q000097:blood; D001323:Autoantibodies / Q000096:biosynthesis / Q000097:blood*; D015897:Comorbidity; D004781:Environmental Exposure / Q000009:adverse effects; D056945:Hep G2 Cells; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012216:Rheumatic Diseases / Q000097:blood / Q000453:epidemiology* / Q000276:immunology*; D012217:Rheumatoid Factor / Q000096:biosynthesis / Q000097:blood; D012822:Silicon Dioxide / Q000276:immunology* / Q000506:poisoning; D012829:Silicosis / Q000097:blood / Q000453:epidemiology* / Q000276:immunology*
D019268:Antibodies, Antineutrophil Cytoplasmic; D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D012822:Silicon Dioxide; D012217:Rheumatoid Factor
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