title: [Influence of Lepidium meyemii walp on lipid and bone mass in ovariectomized rats].
abstract: OBJECTIVE
  To observe the potential effects of Lepidium meyemii Waip (MACA) on body fat, sexual hormone, bone metabolism in post-ovariectomized rats.
  
  
  METHODS
  Healthy Sprague-Dawley rats were randomly divided into 6 groups: sham operated group, ovariectomized model group (OVX), OVX + estrogen treated group (0.3 g/kg), OVX + Maca low dose treated group (0.3 g/kg), OVX + Maca middle dose treated group (0.6 g/kg) and OVX + Maca high dose treated group (1.8 g/kg). After 7 weeks treated the rats were sacrificed, the body weight, uterus and adrenal gland weight were measured, the blood lipids, sexual hormone, bone metabolism were analyzed.
  
  
  RESULTS
  In ovariectomized model group (GYX) the level of estrogen, progesterone, testosterone and the weigh of uterine and adrenal were decreased, the body weight gain, serum lipid and the activities of alkaline phosphatase (ALP) were increased (compared with sham operated group, P < 0.01), though the change of femoral bone density and mineral content was not observed. The blood estrogen and BPG level were increased in OVX + MACA high dose treated group, and had less uterine weight loss and body weight gain, while, the triglyceride, LDL-C and ALP level were similar to sham operated group.
  
  
  CONCLUSIONS
  Dietary supplementation with Maca may have potential effects on prevention from poatmenopausal lipid abnormality and bone metabolism via a different mechanism from estrogen.
authors.affiliation: Institute for Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
authors.forename: Zhu
authors.initials: Z
authors.lastname: Wang
authors.forename: Jingming
authors.initials: J
authors.lastname: Yang
authors.forename: Guodong
authors.initials: G
authors.lastname: Wang
authors.forename: Lihua
authors.initials: L
authors.lastname: Bian
mesh_terms: D000818:Animals; D004967:Estrogens / Q000097:blood; D005260:Female; D029686:Lepidium / Q000737:chemistry*; D050356:Lipid Metabolism / Q000187:drug effects*; D008055:Lipids / Q000097:blood; D015675:Osteocalcin / Q000097:blood; D010024:Osteoporosis / Q000517:prevention & control*; D010052:Ovariectomy; D010936:Plant Extracts / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D015430:Weight Gain / Q000187:drug effects
chemical_list: D004967:Estrogens; D008055:Lipids; D010936:Plant Extracts; D015675:Osteocalcin