Short communication: Genome-wide scan for bovine milk-fat composition. II. Quantitative trait loci for long-chain fatty acids.
We present the results of a genome-wide scan to identify quantitative trait loci (QTL) that contribute to genetic variation in long-chain milk fatty acids. Milk-fat composition phenotypes were available on 1,905 Dutch Holstein-Friesian cows. A total of 849 cows and their 7 sires were genotyped for 1,341 single nucleotide polymorphisms across all Bos taurus autosomes (BTA). We detected significant QTL on BTA14, BTA15, and BTA16: for C18:1 cis-9, C18:1 cis-12, C18:2 cis-9,12, CLA cis-9,trans-11, C18:3 cis-9,12,15, the C18 index, the total index, total saturated fatty acids, total unsaturated fatty acids (UFA), and the ratio of saturated fatty acids:unsaturated fatty acids on BTA14; for C18:1 trans fatty acids on BTA15; and for the C18 and CLA indices on BTA16. The QTL explained 3 to 19% of the phenotypic variance. Suggestive QTL were found on 16 other chromosomes. The diacylglycerol acyltransferase 1 (DGAT1) K232A polymorphism on BTA14, which is known to influence fatty acid composition, most likely explains the QTL that was detected on BTA14.
Schennink
A
A
Animal Breeding and Genomics Centre, Wageningen University, Wageningen, the Netherlands. aschennink@ucdavis.edu
Stoop
W M
WM
Visker
M H P W
MH
van der Poel
J J
JJ
Bovenhuis
H
H
van Arendonk
J A M
JA
D000818:Animals; D002417:Cattle / Q000235:genetics*; D051048:Diacylglycerol O-Acyltransferase / Q000235:genetics; D005223:Fats / Q000737:chemistry*; D005227:Fatty Acids / Q000235:genetics*; D005260:Female; D055106:Genome-Wide Association Study; D008297:Male; D008892:Milk / Q000737:chemistry*; D010641:Phenotype; D040641:Quantitative Trait Loci / Q000235:genetics*
D005223:Fats; D005227:Fatty Acids; D051048:Diacylglycerol O-Acyltransferase