title: Safety aspects of GH replacement.
abstract: In adults, GH replacement therapy will often be maintained for decades. Owing to the long duration of GH replacement in many adults, it is essential to establish the long-term safety aspects of the treatment. In this review, studies that have investigated the safety profile of long-term GH replacement will be reviewed with an emphasis on studies based on data from the Pfizer International Metabolic Database (KIMS). These studies show that long-term GH replacement in adults is safe and that long-term GH replacement may even improve cardiovascular mortality and morbidity in GH-deficient adults.
authors.affiliation: Department of Endocrinology, Research Centre for Endocrinology and Metabolism, Sahlgrenska University Hospital, Göteborg, Sweden. johan.svensson@medic.gu.se <johan.svensson@medic.gu.se>
authors.forename: Johan
authors.initials: J
authors.lastname: Svensson
authors.forename: Bengt-Ake
authors.initials: BA
authors.lastname: Bengtsson
mesh_terms: D000328:Adult; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000401:mortality / Q000517:prevention & control; D016208:Databases, Factual; D003924:Diabetes Mellitus, Type 2 / Q000139:chemically induced / Q000453:epidemiology* / Q000378:metabolism; D019382:Human Growth Hormone / Q000008:administration & dosage / Q000009:adverse effects* / Q000172:deficiency*; D006801:Humans; D007029:Hypothalamic Neoplasms / Q000453:epidemiology; D007328:Insulin / Q000378:metabolism; D007391:International Cooperation; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D009369:Neoplasms / Q000139:chemically induced / Q000453:epidemiology*; D010911:Pituitary Neoplasms / Q000453:epidemiology; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: D007328:Insulin; D019382:Human Growth Hormone