Role of serotonin in systemic impairment of motor function of the digestive tract.
We studied the role of serotonin in systemic impairment of motor function of the digestive tract. Administration of a nitric oxide donor methylene blue into the pre-fundal portion of the stomach and application of a loose ligature to the terminal part of the sigmoid colon were performed after pretreatment with serotonin. Serotonin had a stabilizing effect on esophageal antiperistalsis under conditions of dynamic obstruction of the sigmoid colon.
Lychkova
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AE
Central Research Institute of Gastroenterology, Moscow, Russia. lychkova@mail.ru
D000818:Animals; D012809:Colon, Sigmoid / Q000187:drug effects / Q000503:physiopathology; D003248:Constipation / Q000188:drug therapy / Q000503:physiopathology*; D004576:Electromyography; D004947:Esophagus / Q000187:drug effects / Q000503:physiopathology; D005764:Gastroesophageal Reflux / Q000188:drug therapy / Q000503:physiopathology*; D041981:Gastrointestinal Tract / Q000187:drug effects / Q000503:physiopathology*; D007415:Intestinal Obstruction / Q000188:drug therapy / Q000503:physiopathology; D008751:Methylene Blue / Q000494:pharmacology; D008839:Microelectrodes; D020030:Nitric Oxide Donors / Q000494:pharmacology; D010528:Peristalsis / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000378:metabolism*; D012810:Sigmoid Diseases / Q000188:drug therapy / Q000503:physiopathology; D013270:Stomach / Q000187:drug effects / Q000503:physiopathology
D020030:Nitric Oxide Donors; D012701:Serotonin; D008751:Methylene Blue