title: Prenyloxyphenylpropanoids as a novel class of anticonvulsive agents.
abstract: In this study, we synthesized some natural and semi-synthetic prenyloxyphenylpropanoids (e.g., acetophenones, benzoic and cinnamic acids, chalcones, and coumarins), and we assessed their in vivo neuroprotective activity, using the mouse maximal electroshock-induced seizure model (MES test). 7-Isopentenyloxycoumarin and (2E)-3-{4-[(3-methylbut-2-enyl)oxy]phenyl}prop-2-enoic acid, administered ip at a dose of 300 mg/kg, suppressed MES-induced seizures in mice in a time- and dose-dependent manner.
authors.affiliation: Dipartimento di Scienze del Farmaco, Università G. D'Annunzio di Chieti-Pescara, Via dei Vestini 31, 66013 Chieti Scalo (CH), Italy.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Genovese
authors.forename: Francesco
authors.initials: F
authors.lastname: Epifano
authors.forename: Massimo
authors.initials: M
authors.lastname: Curini
authors.forename: Monika
authors.initials: M
authors.lastname: Dudra-Jastrzebska
authors.forename: Jarogniew J
authors.initials: JJ
authors.lastname: Luszczki
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004597:Electroshock; D045782:Hemiterpenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use*; D051379:Mice; D010647:Phenyl Ethers / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use*; D012640:Seizures / Q000188:drug therapy*
chemical_list: D000927:Anticonvulsants; D045782:Hemiterpenes; D010647:Phenyl Ethers