title: [Gastrointestinal hormones in food intake control].
abstract: The discovery of gut hormones regulating the energy balance has aroused great interest in the scientific community. Some of these hormones modulate appetite and satiety, acting on the hypothalamus or the solitary tract nucleus in the brainstem. In general, the endocrine signals generated in the gut have direct or indirect (through the autonomous nervous system) anorexigenic effects. Only ghrelin, a gastric hormone, has been consistently associated with the initiation of food intake and is regarded as the main orexigenic signal both in animal models and humans. In this review, we provide a brief description of the major gastrointestinal hormones implicated in the regulation of food intake. Given the increased importance of food intake disturbances, especially obesity, a better understanding of the underlying mechanisms of action of the gastrointestinal hormones might contribute to the development of new molecules that could increase the therapeutic arsenal for treating obesity and its associated comorbidities.
authors.affiliation: Laboratorio de Endocrinología, Departamento de Biología Funcional y Ciencias de la Salud, Facultad de Biología, Universidad de Vigo, Vigo, Pontevedra, España.
authors.forename: Mayte Alvarez
authors.initials: MA
authors.lastname: Crespo
authors.forename: Lucas C
authors.initials: LC
authors.lastname: González Matías
authors.forename: Manuel Gil
authors.initials: MG
authors.lastname: Lozano
authors.forename: Soledad Fontans
authors.initials: SF
authors.lastname: Paz
authors.forename: Marina Romaní
authors.initials: MR
authors.lastname: Pérez
authors.forename: Eva Vigo
authors.initials: EV
authors.lastname: Gago
authors.forename: Federico Mallo
authors.initials: FM
authors.lastname: Ferrer
mesh_terms: D002766:Cholecystokinin / Q000502:physiology; D004151:Dipeptides / Q000502:physiology; D004435:Eating / Q000502:physiology*; D005749:Gastric Inhibitory Polypeptide / Q000502:physiology; D005768:Gastrointestinal Hormones / Q000502:physiology*; D054439:Ghrelin / Q000502:physiology; D052216:Glucagon-Like Peptide 1 / Q000502:physiology; D006801:Humans; D053772:Oxyntomodulin / Q000502:physiology; D010191:Pancreatic Polypeptide / Q000502:physiology
chemical_list: D004151:Dipeptides; D005768:Gastrointestinal Hormones; D054439:Ghrelin; D053772:Oxyntomodulin; C042696:tyrosyltyrosine; D005749:Gastric Inhibitory Polypeptide; D010191:Pancreatic Polypeptide; D052216:Glucagon-Like Peptide 1; D002766:Cholecystokinin