title: Hemoglobin variant HbE found in two South Asian diabetic patients.
abstract: Glycohemoglobin, also known as hemoglobin (Hb) A(1c), is a marker of long-term glycemic control in patients with diabetes. We present two South-Asian diabetic patients whose HbA(1c) peaks were not measurable using high performance liquid chromatography (HPLC). Further investigations showed that these patients were homozygous for a hemoglobin variant, HbE (beta26 Glu-->Lys). Because of the increasing numbers of immigrants in Japan, area-specific hemoglobinopathies are now encountered more frequently than before. Thus, if discrepant results are found on an HbA(1c) assay or if the HbA(1c) value cannot be measured, such patients should be screened for hemoglobinopathies and alternative measurements for monitoring diabetes should be considered.
authors.affiliation: Department of Diabetes and Metabolic Medicine, International Medical Center of Japan, Toyama Hospital, Tokyo.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Takarabe
authors.forename: Miyako
authors.initials: M
authors.lastname: Kishimoto
authors.forename: Takahisa
authors.initials: T
authors.lastname: Tanaka
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kajio
authors.forename: Keiko
authors.initials: K
authors.lastname: Harano
authors.forename: Mitsuhiko
authors.initials: M
authors.lastname: Noda
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics*; D001774:Blood Chemical Analysis / Q000379:methods; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000235:genetics*; D005260:Female; D014644:Genetic Variation / Q000235:genetics*; D006442:Glycated Hemoglobin / Q000235:genetics; D006446:Hemoglobin E / Q000235:genetics*; D006801:Humans; D008875:Middle Aged
chemical_list: D006442:Glycated Hemoglobin; D006446:Hemoglobin E; C517652:hemoglobin A1c protein, human