title: The sickness unto Deaf.
abstract: While promiscuous expression of tissue-specific antigens (TSAs) in the thymus is essential for self-tolerance, immunologically relevant TSA expression may also occur in the secondary lymphoid organs. A new study links the transcriptional regulator Deaf1 with altered TSA expression in the secondary lymphoid organs and autoimmune diabetes.
authors.forename: James M
authors.initials: JM
authors.lastname: Gardner
authors.forename: Mark S
authors.initials: MS
authors.lastname: Anderson
mesh_terms: D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D004268:DNA-Binding Proteins; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology*; D008198:Lymph Nodes / Q000276:immunology*; D051379:Mice; D016688:Mice, Inbred NOD; D009687:Nuclear Proteins / Q000502:physiology*; D010179:Pancreas / Q000276:immunology*; D017634:Self Tolerance; D014157:Transcription Factors / Q000502:physiology; D000096927:AIRE Protein
chemical_list: D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; D014157:Transcription Factors; D000096927:AIRE Protein; C116013:DEAF1 protein, human
references.citation: Nat Genet. 1997 Dec;17(4):393-8
references.pmid: 9398839
references.citation: BMC Dev Biol. 2008 Oct 01;8:94
references.pmid: 18826651
references.citation: Int Immunol. 1995 May;7(5):715-25
references.pmid: 7547699
references.citation: Mol Cell Biol. 2004 Mar;24(5):2074-82
references.pmid: 14966286
references.citation: Clin Immunol. 2008 Nov;129(2):195-201
references.pmid: 18801706
references.citation: Genesis. 2002 Jun;33(2):67-76
references.pmid: 12112874
references.citation: Mol Endocrinol. 1998 Oct;12(10):1619-39
references.pmid: 9773984
references.citation: Proc Natl Acad Sci U S A. 1994 Jul 5;91(14):6707-11
references.pmid: 8022837
references.citation: Nat Immunol. 2001 Nov;2(11):1032-9
references.pmid: 11600886
references.citation: Nat Immunol. 2007 Feb;8(2):181-90
references.pmid: 17195844
references.citation: Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15418-23
references.pmid: 9860983
references.citation: Science. 2002 Nov 15;298(5597):1395-401
references.pmid: 12376594
references.citation: J Immunol. 2007 Jul 15;179(2):993-1003
references.pmid: 17617591
references.citation: Science. 2008 Aug 8;321(5890):843-7
references.pmid: 18687966
references.citation: EMBO J. 1996 Apr 15;15(8):1961-70
references.pmid: 8617243