title: [Therapy for prenatally diagnosed lymphangioma--multimodal procedure and interdisciplinary challenge].
abstract: BACKGROUND
  Ultrasound diagnostics enable the prenatal diagnosis of extensive lymphatic malformations. The diagnosis is made prenatally or directly after birth in 50-60% of the cases, in about 80% of the afflicted in the first year of life and up to 90% of the cases in the second year of life. PRENATAL DIAGNOSTICS AND POSSIBILITIES OF PRE- AND PERINATAL INTERVENTIONS: The so called hygroma colli is a primary symptom, which is detected during the routine ultrasound examination. Lymphatic malformations, which are diagnosed antenatally are often associated with chromosome abnormalities. The EXIT procedure allows invasive therapeutic or diagnostic interventions. Hereby the airway safety of Newborns with extended cervical or zerviko-facial lymphangiomas can be warranted. The survival chance and the prognosis may be significantly improved. MANIFESTATION AND ENT-CLINICS: 72 patients (mean age 12.3 yrs) with lymphatic malformations of the Head and Neck presented for the first time during a 5-years period until 31.12.2008 at the Department of Otolaryngology of the University of Marburg. Therapeutic interventions consisted in conventional surgery, laser assisted therapy, sclerosing therapy or a combined therapeutic approach.
  
  
  CONCLUSIONS
  Extensive lymphatic malformations of the Head and Neck challenge treating physicians and affected families. Advancements of prenatal diagnostics and opportunities of peri- and postnatal interventions contribute to an improved survival chance and prognosis. Intensive interdisciplinary cooperation in specialised centers is of outstanding importance for an optimal care of these patients.
authors.affiliation: Klinik für Hals-, Nasen- und Ohrenheilkunde der Philipps-Universität Marburg, Universitätsklinikum Giessen und Marburg, Standort Marburg.
authors.forename: B
authors.initials: B
authors.lastname: Eivazi
authors.forename: F
authors.initials: F
authors.lastname: Sierra-Zuleta
authors.forename: S
authors.initials: S
authors.lastname: Ermisch
authors.forename: L
authors.initials: L
authors.lastname: Hellmeyer
authors.forename: S
authors.initials: S
authors.lastname: Schmidt
authors.forename: J A
authors.initials: JA
authors.lastname: Werner
mesh_terms: D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D006258:Head and Neck Neoplasms / Q000000981:diagnostic imaging* / Q000196:embryology / Q000628:therapy*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D053685:Laser Therapy / Q000379:methods*; D008202:Lymphangioma / Q000000981:diagnostic imaging* / Q000196:embryology / Q000628:therapy*; D008297:Male; D010348:Patient Care Team; D015911:Sclerotherapy / Q000379:methods*; D016896:Treatment Outcome; D016216:Ultrasonography, Prenatal