title: Mid-dilution hemodiafiltration: a comparison with pre- and postdilution modes using the same polyphenylene membrane.
abstract: As a change from Diapes to polyphenylene membrane in the mid-dilution filter has recently been developed, the aim of this study was to compare mid-dilution using this new dialyzer versus pre- and postdilution. The prospective study included 20 patients who underwent 4 hemodiafiltration (HDF) sessions: 1.7 m(2) polyphenylene and predilution infusion flow (Qi) 200 ml/min, 1.7 m(2) and postdilution Qi 100 ml/min, 1.9 and 2.2 m(2) mid-dilution both with Qi 200 ml/ min. The urea and creatinine reduction ratios were slightly higher in postdilution. The beta(2)-microglobulin (85.8%), myoglobin (73.6%), prolactin (67.8%) and retinol-binding protein (29.2%) reduction ratios with 1.9 m(2) mid-dilution, which was similar to 2.2 m(2) mid-dilution, were significantly higher than with the post- and predilution modes. Mid-dilution appears to be a good HDF alternative that allows a better removal of larger molecules than postdilution and, mainly, predilution. Mid-dilution using 1.9 or 2.2 m(2) dialyzers, at the same convective volume, showed a similar removal.
authors.affiliation: Department of Nephrology, Hospital Clínic Barcelona, Barcelona, Spain.
authors.forename: Francisco
authors.initials: F
authors.lastname: Maduell
authors.forename: Marta
authors.initials: M
authors.lastname: Arias
authors.forename: Manel
authors.initials: M
authors.lastname: Vera
authors.forename: Néstor
authors.initials: N
authors.lastname: Fontseré
authors.forename: Miquel
authors.initials: M
authors.lastname: Blasco
authors.forename: Xoana
authors.initials: X
authors.lastname: Barros
authors.forename: Julia
authors.initials: J
authors.lastname: Garro
authors.forename: Montserrat
authors.initials: M
authors.lastname: Elena
authors.forename: Eduardo
authors.initials: E
authors.lastname: Bergadá
authors.forename: Aleix
authors.initials: A
authors.lastname: Cases
authors.forename: Jose Luis
authors.initials: JL
authors.lastname: Bedini
authors.forename: Josep M
authors.initials: JM
authors.lastname: Campistol
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001798:Blood Proteins / Q000032:analysis; D003404:Creatinine / Q000097:blood; D005260:Female; D017583:Hemodiafiltration / Q000379:methods*; D006438:Hemodilution / Q000379:methods*; D006801:Humans; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D014508:Urea / Q000097:blood
chemical_list: D001798:Blood Proteins; D008567:Membranes, Artificial; D014508:Urea; D003404:Creatinine