Addiction related alteration in resting-state brain connectivity.
It is widely accepted that addictive drug use is related to abnormal functional organization in the user's brain. The present study aimed to identify this type of abnormality within the brain networks implicated in addiction by resting-state functional connectivity measured with functional magnetic resonance imaging (fMRI). With fMRI data acquired during resting state from 14 chronic heroin users (12 of whom were being treated with methadone) and 13 non-addicted controls, we investigated the addiction related alteration in functional connectivity between the regions in the circuits implicated in addiction with seed-based correlation analysis. Compared with controls, chronic heroin users showed increased functional connectivity between nucleus accumbens and ventral/rostral anterior cingulate cortex (ACC), between nucleus accumbens and orbital frontal cortex (OFC), and between amygdala and OFC and reduced functional connectivity between prefrontal cortex and OFC and between prefrontal cortex and ACC. These observations of altered resting-state functional connectivity suggested abnormal functional organization in the addicted brain and may provide additional evidence supporting the theory of addiction that emphasizes enhanced salience value of a drug and its related cues but weakened cognitive control in the addictive state.
Ma
Ning
N
Division of Bio-X Interdisciplinary Sciences at the Hefei National Laboratory for Physical Sciences at Microscale, Department of Neurobiology & Biophysics, School of Life Sciences, University of Science & Technology of China, Hefei, Anhui, China.
Liu
Ying
Y
Li
Nan
N
Wang
Chang-Xin
CX
Zhang
Hao
H
Jiang
Xiao-Feng
XF
Xu
Hu-Sheng
HS
Fu
Xian-Ming
XM
Hu
Xiaoping
X
Zhang
Da-Ren
DR
D000328:Adult; D000679:Amygdala / Q000503:physiopathology; D001921:Brain / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000503:physiopathology; D007839:Functional Laterality / Q000502:physiology; D006556:Heroin Dependence / Q000503:physiopathology* / Q000534:rehabilitation; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008691:Methadone / Q000627:therapeutic use; D009294:Narcotics / Q000627:therapeutic use; D009434:Neural Pathways / Q000503:physiopathology*; D009714:Nucleus Accumbens / Q000503:physiopathology; D012146:Rest / Q000502:physiology
D009294:Narcotics; D008691:Methadone
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