Super-coil me: sizing up centromeric nucleosomes.
Every chromosome needs a centromere for proper segregation during cell division. Centromeric chromatin wraps around histones, providing an anchor for kinetochore proteins and spindle attachment. It is clear why cells need centromeres, but how they form and what they look like is less so. Recent reports extend our understanding of chaperones involved in centromere formation. And other accounts of half-sized, right-handed nucleosomes have created an unexpected twist.
Hill
Emma
E
ehill@rockefeller.edu
Williams
Ruth
R
D001324:Autoantigens / Q000378:metabolism; D002503:Centromere / Q000737:chemistry / Q000378:metabolism*; D000076247:Centromere Protein A; D002843:Chromatin / Q000737:chemistry / Q000378:metabolism*; D002868:Chromosomal Proteins, Non-Histone / Q000378:metabolism; D004278:DNA, Superhelical / Q000737:chemistry / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000378:metabolism; D006657:Histones / Q000378:metabolism; D006801:Humans; D008958:Models, Molecular; D009707:Nucleosomes / Q000378:metabolism*; D011487:Protein Conformation
D001324:Autoantigens; D000076247:Centromere Protein A; D002843:Chromatin; D002868:Chromosomal Proteins, Non-Histone; D004278:DNA, Superhelical; D004268:DNA-Binding Proteins; C524371:HJURP protein, human; D006657:Histones; D009707:Nucleosomes
PLoS Biol. 2007 Aug;5(8):e218
17676993
Cell. 2009 May 1;137(3):472-84
19410544
J Cell Biol. 2009 May 4;185(3):397-407
19398759
Cell. 2009 May 1;137(3):485-97
19410545
J Mol Biol. 1999 Aug 27;291(4):815-41
10452891
Cell. 2009 Jun 26;137(7):1173-4
19563746
Mol Cell. 2007 Jan 26;25(2):309-22
17244537
Curr Opin Cell Biol. 2008 Feb;20(1):91-100
18226513
Nat Cell Biol. 2009 Jul;11(7):896-902
19543270
Nature. 1997 Sep 18;389(6648):251-60
9305837
J Cell Biol. 2008 Dec 29;183(7):1193-202
19114591
Cell. 2009 Jul 10;138(1):104-13
19596238
Cell. 2007 Jun 15;129(6):1153-64
17574026
Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):7266-71
10840064
J Mol Biol. 2007 Jul 13;370(3):555-73
17524417
Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):5008-13
17360341
J Cell Biol. 2008 Dec 1;183(5):805-18
19047461