title: A case report supporting the concept that some women have a predisposition for maternal meiosis errors resulting in digyny.
abstract: OBJECTIVE
  To determine if a primary aborter with recurrent miscarriage times three with her only two fetal products that were evaluated with chromosome analysis demonstrating triploidy in both fetuses could have a predisposition for maternal meiosis errors.
  
  
  METHODS
  In vitro fertilization with intracytoplasmic sperm injection was performed. Embryo biopsy was performed on 3-day old embryos and a single blastomere was evaluated by fluorescent in situ hybridization (FISH). Embryo transfer would be performed on day 5 at the blastocyst stage.
  
  
  RESULTS
  There were six normal and seven abnormal embryos. One of the seven was a tetraploid embryo (92XXXX).
  
  
  CONCLUSIONS
  The majority of triploidies are related to polyspermy but this factor was excluded by performing ICSI. Thus this woman showed a marked predisposition to digyny. Though the tetraploidy could be explained by fertilization of a digynic egg by a diploid sperm the probability was that in this instance the meiosis error extended back to failure to extrude the first polar body.
authors.affiliation: The University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden, Cooper Hospital/University Medical Center, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology & Infertility, Camden, NJ, USA. laurie@ccivf.com
authors.forename: J H
authors.initials: JH
authors.lastname: Check
authors.forename: B
authors.initials: B
authors.lastname: Katsoff
authors.forename: D
authors.initials: D
authors.lastname: Summers-Chase
authors.forename: J
authors.initials: J
authors.lastname: Breitbart
mesh_terms: D000026:Abortion, Habitual / Q000235:genetics*; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D008540:Meiosis / Q000235:genetics*; D010063:Ovum; D011123:Polyploidy; D011247:Pregnancy; D019836:Preimplantation Diagnosis; D055815:Young Adult