title: Sheehan's syndrome with pancytopenia--complete recovery after hormone replacement (case series with review).
abstract: Reports of pancytopenia in patients with Sheehan's syndrome are rare, because the disorder is not commonly seen in western countries. A case series of pancytopenia in three patients of Sheehan's syndrome is presented. Three women aged 22, 30, and 34 years developed Sheehan's syndrome preceded by post partum hemorrhage. During investigations, they were found to have pancytopenia with hypocellular marrow. Treatment with thyroxine and glucocorticoids resulted in complete recovery after attaining euthyroid and eucortisolemic state. Review of literature revealed the rarity of the disorder, with only four cases reported so far. Multiple anterior pituitary hormone deficiencies in Sheehan's syndrome are responsible for pancytopenia; replacement of thyroid and cortisol hormones results in complete recovery.
authors.affiliation: Department of Endocrinology, Sher-i-Kashmir Institute of Medical Sciences, Soura, Srinagar, Jammu and Kashmir, India.
authors.forename: Bashir Ahmad
authors.initials: BA
authors.lastname: Laway
authors.forename: Javid Rasool
authors.initials: JR
authors.lastname: Bhat
authors.forename: Shahnaz Ahmad
authors.initials: SA
authors.lastname: Mir
authors.forename: Raja Sultan Zaman
authors.initials: RS
authors.lastname: Khan
authors.forename: Mohd Iqbal
authors.initials: MI
authors.lastname: Lone
authors.forename: Abdul Hamid
authors.initials: AH
authors.lastname: Zargar
mesh_terms: D000328:Adult; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007018:Hypopituitarism / Q000150:complications* / Q000188:drug therapy; D010198:Pancytopenia / Q000188:drug therapy / Q000209:etiology*; D010907:Pituitary Hormones / Q000172:deficiency; D006473:Postpartum Hemorrhage; D011247:Pregnancy; D013974:Thyroxine / Q000627:therapeutic use; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D005938:Glucocorticoids; D010907:Pituitary Hormones; D013974:Thyroxine