title: High-resolution adaptive PET imaging.
abstract: While the performance of small animal PET systems has been improved impressively in terms of spatial resolution and sensitivity, demands for further improvements remain high with growing number of applications. Here we propose a novel PET system design that integrates a high-resolution detector into an existing PET system to obtain higher-resolution images in a target region. The high-resolution detector will be adaptively positioned based on the detectability or quantitative accuracy of a feature of interest. The proposed system will be particularly effective for studying human cancers using animal models where tumors are often grown near the skin surface and therefore permit close contact with the high resolution detector. It will also be useful for the high-resolution brain imaging in rodents. In this paper, we present the theoretical analysis and Monte Carlo simulation studies of the performance of the proposed system.
authors.affiliation: Department of Biomedical Engineering, University of California-Davis, California, USA.
authors.forename: Jian
authors.initials: J
authors.lastname: Zhou
authors.forename: Jinyi
authors.initials: J
authors.lastname: Qi
mesh_terms: D000465:Algorithms; D000818:Animals; D017076:Computer-Aided Design; D004867:Equipment Design; D019544:Equipment Failure Analysis; D007089:Image Enhancement / Q000295:instrumentation* / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000295:instrumentation* / Q000379:methods; D009369:Neoplasms / Q000000981:diagnostic imaging*; D049268:Positron-Emission Tomography / Q000295:instrumentation* / Q000662:veterinary*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014159:Transducers / Q000662:veterinary*