Connexin 43 gap junction plaque endocytosis implies molecular remodelling of ZO-1 and c-Src partners.
Gap junctions, through their constitutive proteins, connexins (Cx), are involved in several processes including regulation of cellular proliferation, tissue differentiation, homeostasis and neoplasic transformation. Internalization of the gap junction plaque to form annular gap junction is a dynamic process, which present similarities with endocytosis, and participates in the control of gap junction coupling. Cx43 exhibits dynamic trafficking that needs sequential implication of a large number of protein partners. We have recently shown that ZO-1 localized in both sides of the gap junction plaque was restricted to one side during internalization. The dissociation between ZO-1 and Cx43 particularly occurred on the face where c-Src specifically associated with Cx43 and was abnormally accelerated in response to a carcinogen. In this addendum we summarize and further discuss these results.
Gilleron
Jérome
J
Université Paris Descartes; Paris, France.
Carette
Diane
D
Fiorini
Céline
C
Benkdane
Merieme
M
Segretain
Dominique
D
Pointis
Georges
G
Circ Res. 2004 Feb 6;94(2):215-22
14699011
J Cell Sci. 2008 Dec 15;121(Pt 24):4069-78
19033388
Mol Biol Cell. 2003 Jun;14(6):2470-81
12808044
J Biol Chem. 2004 Dec 24;279(52):54695-701
15492000
J Biol Chem. 1998 May 22;273(21):12725-31
9582296
Circ Res. 2002 Feb 22;90(3):317-24
11861421
FEBS Lett. 2001 Sep 7;505(1):92-6
11557048
Eur J Neurosci. 2004 Apr;19(8):2132-46
15090040
J Biol Chem. 2001 Jan 19;276(3):1780-8
11035005
Cell Signal. 2007 May;19(5):958-67
17210245
Biochim Biophys Acta. 2002 Jun 21;1602(2):114-30
12020799
Crit Rev Oncog. 2006 Dec;12(3-4):225-56
17425504
Mol Biol Cell. 2005 Dec;16(12):5686-98
16195341
Science. 1999 Feb 19;283(5405):1176-80
10024245
Circ Res. 1992 Jun;70(6):1233-43
1315637
Proc Natl Acad Sci U S A. 1991 May 1;88(9):3525-9
1850831
J Biol Chem. 2002 Oct 11;277(41):38272-83
12154091
J Biol Chem. 2005 Mar 4;280(9):7941-8
15618229
Biochim Biophys Acta. 2008 Jan;1778(1):56-67
17949680
Exp Cell Res. 2007 Dec 10;313(20):4083-90
17956757
Biochimie. 2004 Apr-May;86(4-5):241-4
15194225
Prog Biophys Mol Biol. 2007 May-Jun;94(1-2):29-65
17507078
Biochim Biophys Acta. 2005 Jun 10;1711(2):215-24
15955306
Carcinogenesis. 2001 Sep;22(9):1537-42
11532877
J Biol Chem. 2001 Jun 22;276(25):23051-5
11313345
Curr Biol. 1998 Jul 30-Aug 13;8(16):931-4
9707407
Carcinogenesis. 2003 Aug;24(8):1415-23
12807735
Biochim Biophys Acta. 2008 Mar;1778(3):660-9
17854762
J Cell Biol. 1998 Mar 9;140(5):1199-209
9490732
Curr Med Chem. 2007;14(21):2288-303
17896977