Lumcorin: a leucine-rich repeat 9-derived peptide from human lumican inhibiting melanoma cell migration.
We previously showed that lumican decreases melanoma progression. The aim of the present study was to determine the active sequence of the lumican core protein responsible for the inhibition of melanoma cell migration. Using different recombinant and synthetic peptides derived from lumican, we localized an active site in the leucine-rich repeat 9 domain of the lumican core protein. We propose the name lumcorin (fragment of lumican core protein) for the active peptide derived from this site. Lumcorin was able to inhibit melanoma cell migration in vitro.
Zeltz
Cédric
C
Laboratoire de Biochimie Médicale et de Biologie Moléculaire, CNRS UMR 6237, Université Reims-Champagne-Ardenne, F-51095 Reims, France.
Brézillon
Stéphane
S
Perreau
Corinne
C
Ramont
Laurent
L
Maquart
François-Xavier
FX
Wegrowski
Yanusz
Y
D017209:Apoptosis / Q000187:drug effects; D020134:Catalytic Domain; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D011508:Chondroitin Sulfate Proteoglycans / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D007632:Keratan Sulfate / Q000737:chemistry* / Q000627:therapeutic use; D000071234:Lumican; D008545:Melanoma / Q000188:drug therapy* / Q000473:pathology; D010446:Peptide Fragments / Q000494:pharmacology* / Q000627:therapeutic use
D011508:Chondroitin Sulfate Proteoglycans; C000604306:LUM protein, human; D000071234:Lumican; D010446:Peptide Fragments; C544543:lumcorin; D007632:Keratan Sulfate