Effect of liposomes containing antioxidant, phospholipid, and amino acid on skin regeneration after chemical burn.
Liposomes containing natural flavonoid dihydroquercetin, phospholipid lecithin, and zwitterionic amino acid glycine were used for the therapy of glacial acetic acid-induced chemical burn. No inflammatory reaction was observed in the region of wound. The area of postburn injury did not increase in time. Planimetry and histological studies showed that improved skin regeneration was accompanied by repair of hair follicles and sebaceous glands.
Naumov
A A
AA
Group of Functional Biochemistry, Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino.
Shatalin
Yu V
YV
Sukhomlin
T K
TK
Potselueva
M M
MM
D019342:Acetic Acid; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use; D002057:Burns, Chemical / Q000188:drug therapy* / Q000276:immunology; D005998:Glycine / Q000627:therapeutic use; D018859:Hair Follicle / Q000187:drug effects / Q000293:injuries / Q000473:pathology; D054709:Lecithins / Q000627:therapeutic use; D008081:Liposomes / Q000627:therapeutic use; D008297:Male; D011794:Quercetin / Q000031:analogs & derivatives / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D012038:Regeneration / Q000187:drug effects*; D012627:Sebaceous Glands / Q000187:drug effects / Q000293:injuries / Q000473:pathology; D012867:Skin / Q000187:drug effects* / Q000293:injuries* / Q000473:pathology; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects
D000975:Antioxidants; D054709:Lecithins; D008081:Liposomes; D011794:Quercetin; C003377:taxifolin; D019342:Acetic Acid; D005998:Glycine