title: Autoimmune polyendocrine syndrome type I and brain calcinosis.
abstract: Autoimmune polyendocrine syndrome (APS) is a rare disorder. One of the possible associated endocrinopathies in APS is hypoparathyroidism. We describe brain calcifications secondary to hypoparathyroidism in family members with APS and compare clinical manifestations, the extent of brain calcifications on CT scans and the result of PET-FDG scans. We found extensive brain calcifications and striatal hypometabolism in PET-FDG scan in the only symptomatic member of the family, which supports the assumption that extensive brain calcification and the presence of hypometabolism in PET-FDG scan are likely to be found in symptomatic patients with brain calcifications.
authors.affiliation: Department of Neurology, Rabin Medical Center, Beilinson Campus, Petah Tiqwa, Israel. alona3@clalit.org.il
authors.forename: Alon
authors.initials: A
authors.lastname: Abraham
authors.forename: Ilan
authors.initials: I
authors.lastname: Ziv
authors.forename: Adam
authors.initials: A
authors.lastname: Steinmetz
authors.forename: David
authors.initials: D
authors.lastname: Groshar
authors.forename: Ruth
authors.initials: R
authors.lastname: Djaldetti
mesh_terms: D000328:Adult; D001927:Brain Diseases / Q000150:complications* / Q000000981:diagnostic imaging; D002114:Calcinosis / Q000150:complications* / Q000000981:diagnostic imaging; D005192:Family Health; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D008875:Middle Aged; D016884:Polyendocrinopathies, Autoimmune / Q000150:complications* / Q000000981:diagnostic imaging; D049268:Positron-Emission Tomography / Q000379:methods; D055815:Young Adult
chemical_list: D019788:Fluorodeoxyglucose F18