title: The -786 T/C polymorphism of the NOS3 gene is associated with elite performance in power sports.
abstract: The NOS3 gene is a candidate to explain individual variations in health and exercise related phenotypes. We compared genotypic and allelic frequencies of the NOS3 -786 T/C polymorphism (rs2070744) in three groups of men of the same Caucasian (Spanish) descent: (i) elite endurance athletes (cyclists, runners; N = 100); (ii) elite power athletes (jumpers, throwers, sprinters; N = 53) and (iii) non-athletic controls (N = 100). The frequency of the TT genotype was significantly higher in power athletes (57%) than in the endurance (33%, P = 0.017) or control group (34%, P = 0.026). The frequency of the T allele was also higher in power sportsmen (71%) than in their endurance (55%, P = 0.003) and control referents (56%, P = 0.015). No differences were observed between control and endurance groups. In summary, the -786 T/C polymorphism of the NOS3 gene seems to be associated with elite performance in power-oriented athletic events (throwing, jumping, sprinting), with the T allele exerting a beneficial effect. The mechanism by which this allele variant might benefit power performance remains to be elucidated.
authors.affiliation: Universidad Europea de Madrid, 28670 Villaviciosa de Odón, Madrid, Spain.
authors.forename: Félix
authors.initials: F
authors.lastname: Gómez-Gallego
authors.forename: Jonatan R
authors.initials: JR
authors.lastname: Ruiz
authors.forename: Amaya
authors.initials: A
authors.lastname: Buxens
authors.forename: Marta
authors.initials: M
authors.lastname: Artieda
authors.forename: David
authors.initials: D
authors.lastname: Arteta
authors.forename: Catalina
authors.initials: C
authors.lastname: Santiago
authors.forename: Gabriel
authors.initials: G
authors.lastname: Rodríguez-Romo
authors.forename: José I
authors.initials: JI
authors.lastname: Lao
authors.forename: Alejandro
authors.initials: A
authors.lastname: Lucia
mesh_terms: D000328:Adult; D056352:Athletes; D054874:Athletic Performance / Q000502:physiology; D016022:Case-Control Studies; D004252:DNA Mutational Analysis; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D052250:Nitric Oxide Synthase Type III / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000502:physiology; D011401:Promoter Regions, Genetic; D055070:Resistance Training; D013177:Sports / Q000502:physiology; D055815:Young Adult
chemical_list: C496314:NOS3 protein, human; D052250:Nitric Oxide Synthase Type III
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