The role of FIP3-dependent endosome transport during cytokinesis.
Mitosis is a complex cellular process that is completed by the final abscission step called cytokinesis. The many roles of cytoskeletal proteins in animal cell division have been studied extensively, and are essential for proper daughter cell segregation. Lately, the need for the membrane delivery to the cleavage furrow of dividing cells has been implicated as a necessary and important step in cytokinesis.1-4 Newly published work from several group demonstrate that endosomal membranes are required for cytokinesis and also provide insight into the targeting of these membranes to the cleavage furrow.5-8 Rab11 GTPase and its effector protein FIP3 were shown to play key roles in endosome targeting to the cleavage furrow in a spatially and temporally regulated manner.7-9 Thus, Rab11/FIP3 protein complex have emerged as a regulator of endocytic traffic, essential for the abscission step in cytokinesis.
Simon
Glenn C
GC
Department of Cell and Developmental Biology; School of Medicine; University of Colorado Denver; Aurora, Colorado USA.
Prekeris
Rytis
R
Dev Cell. 2003 May;4(5):753-9
12737809
Curr Biol. 2006 Sep 5;16(17):1719-25
16950109
Development. 1998 Apr;125(7):1295-303
9477328
J Cell Biol. 2003 Oct 13;163(1):143-54
14530382
EMBO J. 2008 Jul 9;27(13):1791-803
18511905
J Biol Chem. 2006 Dec 15;281(50):38609-16
17028198
Curr Biol. 1999 Jul 15;9(14):738-45
10421575
J Cell Biol. 1973 Oct;59(1):89-108
4356573
J Biol Chem. 2002 Jul 26;277(30):27210-6
12016212
Development. 2007 Dec;134(24):4437-47
18039970
Biochem Biophys Res Commun. 2004 Jun 18;319(1):83-94
15158446
Mol Biol Cell. 2003 Jul;14(7):2908-20
12857874
EMBO J. 2005 Oct 5;24(19):3389-99
16148947
Nature. 2004 Aug 19;430(7002):908-13
15282614
Dev Biol. 1998 Feb 1;194(1):47-60
9473331
Cell. 2005 Oct 7;123(1):75-87
16213214
J Cell Sci. 1999 Sep;112 ( Pt 17):2885-93
10444383
Mol Biol Cell. 2005 Feb;16(2):849-60
15601896
Eur J Cell Biol. 2007 Aug;86(8):417-31
17628206