title: US-guided diffused optical tomography: a promising functional imaging technique in breast lesions.
abstract: OBJECTIVE
  To investigate the feasibility and clinical efficacy of ultrasound (US)-guided diffused optical tomography (DOT) in differentiating malignant breast lesions from benign lesions.
  
  
  METHODS
  From October 2007 to August 2008, 198 women with 214 lesions scheduled for open biopsy were included in this study. Conventional US was used to locate the breast lesion, and DOT to measure the total haemoglobin concentration (THC) for each breast lesion. Sensitivity, specificity and overall accuracy were determined with surgical pathology as the gold standard.
  
  
  RESULTS
  There were 96 benign lesions and 118 malignant lesions. The total haemoglobin concentration (THC) of all 214 lesions was calculated from DOT. The average THC in benign lesions was 125.5 +/- 83.4 micromol/L, and in malignant lesions 222.2 +/- 87.2 micromol/L. The THC of malignant lesions was significantly higher than that of benign lesions (p < 0.05). When a THC of 140 micromol/L was used as the cutoff value for differentiating breast cancer from benign lesions, the sensitivity, specificity, accuracy, positive predictive value and negative predictive value of DOT were 83.9%, 66.7%, 76.2%, 75.6% and 77.1%, respectively. Our study demonstrated that THC was significantly higher in malignant lesions than in benign lesions.
  
  
  CONCLUSIONS
  US-guided diffused optical tomography, a noninvasive functional imaging technique, has potential utility in differentiating breast cancer from benign lesions.
authors.affiliation: Department of Diagnostic Ultrasound, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, No. 1 Shuaifuyuan, Wangfujing, Beijing 100730, China.
authors.forename: Shan-Shan
authors.initials: SS
authors.lastname: You
authors.forename: Yu-Xin
authors.initials: YX
authors.lastname: Jiang
authors.forename: Qing-Li
authors.initials: QL
authors.lastname: Zhu
authors.forename: Ji-Bin
authors.initials: JB
authors.lastname: Liu
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: Qing
authors.initials: Q
authors.lastname: Dai
authors.forename: He
authors.initials: H
authors.lastname: Liu
authors.forename: Qiang
authors.initials: Q
authors.lastname: Sun
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001707:Biopsy, Needle / Q000379:methods*; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D025321:Surgery, Computer-Assisted / Q000379:methods*; D041622:Tomography, Optical / Q000379:methods*; D016217:Ultrasonography, Mammary / Q000379:methods*; D055815:Young Adult
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