Notch signaling and the bone marrow hematopoietic stem cell niche.
Recently there has been increased interest in the regulatory interactions between osteoblasts and cells in the surrounding bone marrow microenvironment. The proximity of hematopoietic stem cells (HSCs) with osteoblastic cells first suggested regulatory interactions, and recent data have highlighted the role of osteoblastic cells in providing a HSC niche. Reports have indicated that direct contact is necessary to mediate the osteoblastic effects and that these effects could be mediated through Notch activation. Notch signaling is important throughout development and also appears to play a critical role in cellular maturation and differentiation of osteoblastic cells and hematopoietic cells as disregulation can lead to bone loss and leukemias, respectively. In this review we discuss the current understanding of Notch signaling and how it functions in hematopoiesis, osteoblastic cells, and the interactions between HSC and their osteoblastic niche.
Weber
Jonathan M
JM
Endocrine Division, Wilmot Cancer Center, Department of Medicine and Center for Musculoskeletal Research, University of Rochester School of Medicine, Rochester, NY 14642, USA.
Calvi
Laura M
LM
D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology*; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000378:metabolism*; D010006:Osteoblasts / Q000166:cytology / Q000378:metabolism; D051880:Receptors, Notch / Q000378:metabolism*; D015398:Signal Transduction; D055153:Stem Cell Niche / Q000166:cytology / Q000378:metabolism*
D051880:Receptors, Notch
Nature. 2003 Oct 23;425(6960):841-6
14574413
Genes Dev. 1998 Aug 1;12(15):2269-77
9694793
Nat Rev Mol Cell Biol. 2002 Sep;3(9):673-84
12209127
Mol Cell Biol. 2002 Jun;22(11):3927-41
11997524
Genes Dev. 1999 Nov 1;13(21):2801-10
10557208
Arch Biochem Biophys. 2008 May 15;473(2):193-200
18410740
Blood. 2003 Mar 1;101(5):1784-9
12411302
Proc Natl Acad Sci U S A. 1999 Jan 5;96(1):23-8
9874765
Leukemia. 2003 Jul;17(7):1366-74
12835726
J Exp Med. 1996 May 1;183(5):2283-91
8642337
Science. 2004 Oct 8;306(5694):269-71
15472075
Semin Cell Dev Biol. 2003 Apr;14(2):113-9
12651094
Bone. 2006 Sep;39(3):485-93
16647886
J Biol Chem. 2005 Apr 22;280(16):15842-8
15695512
Stem Cells. 1998;16(1):7-15
9474743
Curr Opin Immunol. 2008 Apr;20(2):197-202
18434124
Nature. 2001 Nov 1;414(6859):98-104
11689954
Blood. 1998 Jun 1;91(11):4084-91
9596653
Cell Stem Cell. 2008 Apr 10;2(4):356-66
18397755
Curr Biol. 2006 Dec 5;16(23):2352-8
17070683
Nat Immunol. 2005 Mar;6(3):314-22
15665828
J Biol Chem. 2008 Mar 7;283(10):6509-18
18156632
Nat Med. 2008 Mar;14(3):299-305
18297084
J Exp Med. 2000 Nov 6;192(9):1365-72
11067884
Blood. 2005 Mar 15;105(6):2340-2
15550486
J Bone Miner Res. 2002 Feb;17(2):231-9
11811553
Blood. 2008 Dec 1;112(12):4628-38
18818392
Exp Cell Res. 2003 Nov 1;290(2):370-80
14567994
Immunity. 2000 Jul;13(1):73-84
10933396
Cell. 1991 Aug 23;66(4):649-61
1831692
Nat Med. 2000 Nov;6(11):1278-81
11062542
Blood. 2003 Mar 15;101(6):2227-34
12411305
Nature. 2003 Oct 23;425(6960):836-41
14574412
Cell. 1987 Jul 3;50(1):107-17
3036364
Blood. 2007 Jul 1;110(1):82-90
17360942
Semin Cell Dev Biol. 2003 Apr;14(2):143-50
12651098
Cell Stem Cell. 2007 Nov;1(5):541-54
18345353
Blood Cells. 1978;4(1-2):7-25
747780
Endocrinology. 2003 Dec;144(12):5631-9
12960086
Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15529-34
18832173
Science. 1995 Sep 8;269(5229):1427-9
7660125
Nature. 2003 May 22;423(6938):409-14
12717450
Blood. 2004 May 1;103(9):3258-64
14726388
J Clin Invest. 2002 Oct;110(8):1165-74
12393852
J Bone Miner Res. 2006 Aug;21(8):1317-26
16869730
Endocrinology. 2008 Aug;149(8):3890-9
18420737
J Clin Invest. 2001 Feb;107(3):277-86
11160151
Mol Cell Biol. 2000 Apr;20(7):2400-10
10713164
Blood. 2002 Apr 1;99(7):2369-78
11895769
Proc Natl Acad Sci U S A. 2009 Jul 14;106(28):11617-22
19564624
Cell. 2007 Oct 19;131(2):324-36
17956733
Transl Res. 2008 Jan;151(1):1-9
18061122
Blood. 2008 Jul 15;112(2):308-19
18359890
Blood. 1999 Feb 1;93(3):838-48
9920832
Cell. 2004 Jul 23;118(2):149-61
15260986
J Cell Biochem. 2002;85(2):252-8
11948681
J Biol Chem. 2008 Aug 15;283(33):22690-9
18583340
Endocrinology. 2007 Apr;148(4):1666-74
17218421
Development. 2007 Mar;134(6):1071-80
17287246
Science. 1999 Apr 30;284(5415):770-6
10221902
J Exp Med. 2005 Jun 6;201(11):1781-91
15928197
J Biol Chem. 2003 May 30;278(22):19723-31
12644456
Endocr Rev. 2007 May;28(3):339-63
17409286
Leuk Lymphoma. 2006 Nov;47(11):2400-3
17107915
Immunity. 1998 Jan;8(1):43-55
9462510
Blood. 2005 Aug 15;106(4):1232-9
15845900
Nat Genet. 2000 Dec;26(4):484-9
11101851
Nat Med. 2008 Mar;14(3):306-14
18297083
EMBO J. 2000 Jul 3;19(13):3337-48
10880446
Bioessays. 2005 Nov;27(11):1117-28
16237675
Blood. 2001 Apr 1;97(7):1960-7
11264159
Nat Biotechnol. 2007 Feb;25(2):238-43
17237769
J Bone Miner Metab. 2003;21(6):344-52
14586790