title: Infliximab in ulcerative colitis.
abstract: Infliximab, a monoclonal anti-TNF-alpha antibody, is commonly used for treatment of moderate to severe Crohn's disease (CD). Its role in the treatment for ulcerative colitis (UC) remains controversial. We review the role of TNF-alpha in the pathogenesis of UC and describe the randomized, double-blind, placebo-controlled trials and systematic reviews that assess the efficacy of infliximab in the treatment of moderate to severe UC.
authors.affiliation: Gastroenterology and Liver Units, Division of Medicine, Hadassah-Hebrew University Medical center, Jerusalem, Israel.
authors.forename: Avi
authors.initials: A
authors.lastname: Levin
authors.forename: Oren
authors.initials: O
authors.lastname: Shibolet
references.citation: Nat Rev Drug Discov. 2006 Mar;5(3):197-209
references.pmid: 16518373
references.citation: Dig Liver Dis. 2002 Sep;34(9):626-30
references.pmid: 12405248
references.citation: N Engl J Med. 1996 Jun 27;334(26):1717-25
references.pmid: 8637518
references.citation: Nature. 2007 Jul 26;448(7152):427-34
references.pmid: 17653185
references.citation: Am J Gastroenterol. 2001 Aug;96(8):2373-81
references.pmid: 11513177
references.citation: Inflamm Bowel Dis. 1999 May;5(2):119-33
references.pmid: 10338381
references.citation: Gut. 1999 May;44(5):643-52
references.pmid: 10205200
references.citation: Nature. 1997 Feb 20;385(6618):729-33
references.pmid: 9034190
references.citation: J Exp Med. 1993 Feb 1;177(2):557-60
references.pmid: 8426126
references.citation: Gastroenterol Hepatol. 2003 Jan;26(1):54-5
references.pmid: 12525332
references.citation: Clin Exp Immunol. 1999 Feb;115(2):294-300
references.pmid: 9933456
references.citation: Best Pract Res Clin Gastroenterol. 2004 Jun;18(3):463-79
references.pmid: 15157821
references.citation: Gastroenterology. 1995 Jul;109(1):129-35
references.pmid: 7797011
references.citation: Gastroenterology. 2005 Jun;128(7):1805-11
references.pmid: 15940615
references.citation: Aliment Pharmacol Ther. 2003 Jul 15;18(2):175-81
references.pmid: 12869077
references.citation: Annu Rev Med. 2000;51:289-98
references.pmid: 10774465
references.citation: Gut. 1998 May;42(5):635-42
references.pmid: 9659156
references.citation: Drugs. 2005;65(15):2179-208
references.pmid: 16225377
references.citation: World J Gastroenterol. 2005 Dec 14;11(46):7227-36
references.pmid: 16437620
references.citation: J Clin Invest. 2006 May;116(5):1218-22
references.pmid: 16670765
references.citation: Inflamm Bowel Dis. 2007 Jun;13(6):727-32
references.pmid: 17260368
references.citation: Gut. 2000 Mar;46(3):336-43
references.pmid: 10673294
references.citation: N Engl J Med. 1994 Jun 30;330(26):1841-5
references.pmid: 8196726
references.citation: Curr Opin Drug Discov Devel. 2001 Sep;4(5):635-50
references.pmid: 12825458
references.citation: Nat Immunol. 2005 Nov;6(11):1133-41
references.pmid: 16200068
references.citation: Clin Exp Immunol. 1990 Aug;81(2):301-5
references.pmid: 2117510
references.citation: FASEB J. 1997 Aug;11(10):743-51
references.pmid: 9271359
references.citation: Am J Gastroenterol. 2004 Aug;99(8):1532-8
references.pmid: 15307873
references.citation: Gastroenterology. 1994 Jun;106(6):1455-66
references.pmid: 8194690
references.citation: Eur J Gastroenterol Hepatol. 2004 Nov;16(11):1167-71
references.pmid: 15489577
references.citation: Lancet. 1992 Jan 11;339(8785):89-91
references.pmid: 1345871
references.citation: Mol Immunol. 1993 Nov;30(16):1443-53
references.pmid: 8232330
references.citation: Gastroenterology. 2006 Mar;130(3):935-9
references.pmid: 16530531
references.citation: Dig Liver Dis. 2002 Sep;34(9):631-4
references.pmid: 12405249
references.citation: Clin Exp Immunol. 1996 Mar;103(3):391-6
references.pmid: 8608636
references.citation: Lancet. 2007 May 12;369(9573):1641-57
references.pmid: 17499606
references.citation: J Immunol. 1999 Jul 15;163(2):1081-90
references.pmid: 10395708
references.citation: Curr Pharm Des. 2004;10(11):1195-205
references.pmid: 15078135
references.citation: Gut. 1997 May;40(5):628-33
references.pmid: 9203942
references.citation: Gut. 2004 Jun;53(6):849-53
references.pmid: 15138212
references.citation: Expert Opin Biol Ther. 2007 Jul;7(7):1051-9
references.pmid: 17665993
references.citation: Inflamm Bowel Dis. 2007 Mar;13(3):308-16
references.pmid: 17206708
references.citation: Annu Rev Immunol. 1992;10:411-52
references.pmid: 1590993
references.citation: Gut. 1975 Aug;16(8):579-84
references.pmid: 1183857
references.citation: Arthritis Rheum. 1993 Dec;36(12):1681-90
references.pmid: 8250987
references.citation: Gut. 2004 Sep;53 Suppl 5:V1-16
references.pmid: 15306569
references.citation: Am J Gastroenterol. 1992 Aug;87(8):971-6
references.pmid: 1642220
references.citation: Gastroenterology. 2007 Feb;132(2):763-86
references.pmid: 17258735
references.citation: Inflamm Bowel Dis. 2001 May;7(2):83-8
references.pmid: 11383595
references.citation: Gastroenterology. 2001 May;120(6):1323-9
references.pmid: 11313301
references.citation: Gastroenterology. 2005 Sep;129(3):1138-9
references.pmid: 16143158
references.citation: Hepatology. 1995 Nov;22(5):1404-8
references.pmid: 7590655
references.citation: Eur J Immunol. 1998 Feb;28(2):730-44
references.pmid: 9521083
references.citation: Gastrointest Endosc. 2002 Jul;56(1):48-54
references.pmid: 12085034
references.citation: Hum Mol Genet. 2002 May 15;11(11):1281-9
references.pmid: 12019209
references.citation: Gut. 2004 Nov;53(11):1556-8
references.pmid: 15479669
references.citation: Cochrane Database Syst Rev. 2005 Jan 25;(1):CD004277
references.pmid: 15674937
references.citation: N Engl J Med. 2005 Dec 8;353(23):2462-76
references.pmid: 16339095
references.citation: Br Med J. 1955 Oct 29;2(4947):1041-8
references.pmid: 13260656
references.citation: Nat Immunol. 2003 Apr;4(4):387-93
references.pmid: 12652297
references.citation: J Clin Invest. 1995 Jan;95(1):55-65
references.pmid: 7814646
references.citation: Tissue Antigens. 2003 Dec;62(6):527-35
references.pmid: 14617036
references.citation: Am J Gastroenterol. 2002 Oct;97(10):2577-84
references.pmid: 12385442
references.citation: Cochrane Database Syst Rev. 2006 Jul 19;(3):CD005112
references.pmid: 16856078
references.citation: Annu Rev Immunol. 2002;20:495-549
references.pmid: 11861611
references.citation: Rev Esp Enferm Dig. 2004 Feb;96(2):94-101
references.pmid: 15255018
references.citation: Gut. 1997 Apr;40(4):443-8
references.pmid: 9176068
references.citation: Clin Ther. 1998 Sep-Oct;20(5):1009-28
references.pmid: 9829451
references.citation: N Engl J Med. 2002 Aug 8;347(6):417-29
references.pmid: 12167685
references.citation: Eur Rev Med Pharmacol Sci. 2004 Sep-Oct;8(5):231-3
references.pmid: 15638236
references.citation: Gut. 1993 Dec;34(12):1705-9
references.pmid: 8031350
references.citation: Aliment Pharmacol Ther. 2007 Jan 1;25(1):19-37
references.pmid: 17229218
references.citation: Gut. 2003 Jul;52(7):998-1002
references.pmid: 12801957
references.citation: Immunol Rev. 2005 Aug;206:260-76
references.pmid: 16048554
references.citation: N Engl J Med. 1987 Dec 24;317(26):1625-9
references.pmid: 3317057
references.citation: Gastroenterol Hepatol. 2004 Aug-Sep;27(7):430-1
references.pmid: 15461945
references.citation: J Immunol. 1997 Dec 15;159(12):6276-82
references.pmid: 9550432
references.citation: Clin Chem. 2001;47(7):1297-301
references.pmid: 11427462
references.citation: Chin Med J (Engl). 2006 Jul 20;119(14):1198-203
references.pmid: 16863613
references.citation: J Clin Pharmacol. 2007 Aug;47(8):930-41
references.pmid: 17567930
references.citation: Nat Rev Immunol. 2003 Jul;3(7):521-33
references.pmid: 12876555
references.citation: Gastroenterology. 2003 Dec;125(6):1576-82
references.pmid: 14724807
references.citation: Nat Med. 2000 May;6(5):583-8
references.pmid: 10802717
references.citation: Science. 1985 Nov 8;230(4726):630-2
references.pmid: 2413547