Mathematical modeling and mechanical and histopathological testing of porous prosthetic pylon for direct skeletal attachment.
This article presents recent results in the development of the skin and bone integrated pylon (SBIP) intended for direct skeletal attachment of limb prostheses. In our previous studies of the porous SBIP-1 and SBIP-2 prototypes, the bond site between the porous pylons and residuum bone and skin did not show the inflammation characteristically observed when solid pylons are used. At the same time, porosity diminished the strength of the pylon. To find a reasonable balance between the biological conductivity and the strength of the porous pylon, we developed a mathematical model of the composite permeable structure. A novel manufacturing process was implemented, and the new SBIP-3 prototype was tested mechanically. The minimal strength requirements established earlier for the SBIP were exceeded threefold. The first histopathological analysis of skin, bone, and the implanted SBIP-2 pylons was conducted on two rats and one cat. The histopathological analysis provided new evidence of inflammation-free, deep ingrowth of skin and bone cells throughout the SBIP structure.
Pitkin
Mark
M
Tufts University School of Medicine, Physical Medicine and Rehabilitation, Boston, MA 02111, USA. mpitkin@tuftsmedicalcenter.org
Raykhtsaum
Grigory
G
Pilling
John
J
Shukeylo
Yuri
Y
Moxson
Vladimir
V
Duz
Volodimir
V
Lewandowski
John
J
Connolly
Raymond
R
Kistenberg
Robert S
RS
Dalton
John F
JF
Prilutsky
Boris
B
Jacobson
Stewart
S
D000818:Animals; D001186:Artificial Limbs; D001842:Bone and Bones / Q000473:pathology; D002415:Cats; D008422:Materials Testing; D008962:Models, Theoretical; D016348:Osseointegration; D011474:Prosthesis Design; D051381:Rats; D012867:Skin / Q000473:pathology; D012879:Skin Physiological Phenomena
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