title: Xanthanolides with antitumour activity from Xanthium italicum.
abstract: Bioassay-guided fractionation of a CHCl3 extract of the leaves of Xanthium italicum Moretti led to the isolation of four xanthanolides: xanthatin (1), 4-epixanthanol (2), 4-epi-isoxanthanol (3), and 2-hydroxyxanthinosin (4). Their structures were determined by means of 1D and 2D NMR spectroscopy, including 1H-1H COSY, NOESY, HSQC and HMBC experiments, which resulted in complete and unambiguous 1H and 13C NMR chemical shift assignments. The isolated compounds 1-4 were evaluated for their antiproliferative activities, and were demonstrated to exert significant cell growth inhibitory activity against human cervix adenocarcinoma (HeLa), skin carcinoma (A431), and breast adenocarcinoma (MCF7) cells.
authors.affiliation: Department of Pharmacognosy, University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary.
authors.forename: Adriána
authors.initials: A
authors.lastname: Kovács
authors.forename: Andrea
authors.initials: A
authors.lastname: Vasas
authors.forename: Peter
authors.initials: P
authors.lastname: Forgo
authors.forename: Borbála
authors.initials: B
authors.lastname: Réthy
authors.forename: István
authors.initials: I
authors.lastname: Zupkó
authors.forename: Judit
authors.initials: J
authors.lastname: Hohmann
mesh_terms: D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001943:Breast Neoplasms; D002455:Cell Division / Q000187:drug effects; D045744:Cell Line, Tumor; D005260:Female; D035264:Flowers / Q000737:chemistry; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D019906:Nuclear Magnetic Resonance, Biomolecular; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D031210:Xanthium / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D010936:Plant Extracts