A new tetrahydrofuran derivative from the endophytic fungus Chaetomium sp. isolated from Otanthus maritimus.
A hitherto unidentified endophytic strain of the genus Chaetomium, isolated from the medicinal plant Otanthus maritimus, yielded a new tetrahydrofuran derivative, aureonitolic acid (1), along with 5 known natural products, 2-6. The structure of 1 was determined by extensive spectroscopic analysis and comparison with reported data. Extracts of the fungus, grown either in liquid culture or on solid rice media, exhibited considerable cytotoxic activity when tested in vitro against L5178Y mouse lymphoma cells. Compounds 2 and 6 showed significant growth inhibition against L5178Y cells with EC50 values of 7.0 and 2.7 microg/mL, respectively, whereas 1 was inactive.
Aly
Amal H
AH
Institut für Pharmazeutische Biologie und Biotechnologie, Heinrich-Heine-Universittät, Universitätsstrasse 1, Geb. 26.23, D-40225 Düsseldorf, Germany.
Debbab
Abdessamad
A
Edrada-Ebel
RuAngelie
R
Wray
Victor
V
Müller
Werner E G
WE
Lin
Wenhan
W
Ebel
Rainer
R
Proksch
Peter
P
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D019659:Asteraceae / Q000382:microbiology*; D045744:Cell Line, Tumor / Q000187:drug effects; D002597:Chaetomium / Q000737:chemistry* / Q000302:isolation & purification; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D007940:Leukemia L5178 / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D013058:Mass Spectrometry / Q000379:methods; D051379:Mice; D010946:Plants, Medicinal / Q000382:microbiology; D011048:Polarography
D000970:Antineoplastic Agents; D005663:Furans