title: Prophylatic treatment of migraine and migraine clinical variants with topiramate: an update.
abstract: Migraine and migraine variants are common, chronic and incapacitating neurovascular disorders with a high impact on health resources. There is an extensive evidence base provided by double-blind, placebo-controlled trials showing that topiramate is a safe, effective and well tolerated drug in the management of migraine and its variants, being especially promising in the management of migraine-vertigo syndrome. Models both in the US and the UK have also shown that it offers a cost benefit when direct and indirect costs are evaluated, by reducing work loss, improving quality of life and reducing the use of increasingly scarce health resources.
authors.affiliation: Department of Neuro-otology and Pain and Headache, Instituto de Neurociencias de Buenos Aires INEBA, Buenos Aires, Argentina;
authors.forename: Sergio
authors.initials: S
authors.lastname: Carmona
authors.forename: Osvaldo
authors.initials: O
authors.lastname: Bruera
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