Infliximab in ulcerative colitis.
Infliximab, a monoclonal anti-TNF-alpha antibody, is commonly used for treatment of moderate to severe Crohn's disease (CD). Its role in the treatment for ulcerative colitis (UC) remains controversial. We review the role of TNF-alpha in the pathogenesis of UC and describe the randomized, double-blind, placebo-controlled trials and systematic reviews that assess the efficacy of infliximab in the treatment of moderate to severe UC.
Levin
Avi
A
Gastroenterology and Liver Units, Division of Medicine, Hadassah-Hebrew University Medical center, Jerusalem, Israel.
Shibolet
Oren
O
Nat Rev Drug Discov. 2006 Mar;5(3):197-209
16518373
Dig Liver Dis. 2002 Sep;34(9):626-30
12405248
N Engl J Med. 1996 Jun 27;334(26):1717-25
8637518
Nature. 2007 Jul 26;448(7152):427-34
17653185
Am J Gastroenterol. 2001 Aug;96(8):2373-81
11513177
Inflamm Bowel Dis. 1999 May;5(2):119-33
10338381
Gut. 1999 May;44(5):643-52
10205200
Nature. 1997 Feb 20;385(6618):729-33
9034190
J Exp Med. 1993 Feb 1;177(2):557-60
8426126
Gastroenterol Hepatol. 2003 Jan;26(1):54-5
12525332
Clin Exp Immunol. 1999 Feb;115(2):294-300
9933456
Best Pract Res Clin Gastroenterol. 2004 Jun;18(3):463-79
15157821
Gastroenterology. 1995 Jul;109(1):129-35
7797011
Gastroenterology. 2005 Jun;128(7):1805-11
15940615
Aliment Pharmacol Ther. 2003 Jul 15;18(2):175-81
12869077
Annu Rev Med. 2000;51:289-98
10774465
Gut. 1998 May;42(5):635-42
9659156
Drugs. 2005;65(15):2179-208
16225377
World J Gastroenterol. 2005 Dec 14;11(46):7227-36
16437620
J Clin Invest. 2006 May;116(5):1218-22
16670765
Inflamm Bowel Dis. 2007 Jun;13(6):727-32
17260368
Gut. 2000 Mar;46(3):336-43
10673294
N Engl J Med. 1994 Jun 30;330(26):1841-5
8196726
Curr Opin Drug Discov Devel. 2001 Sep;4(5):635-50
12825458
Nat Immunol. 2005 Nov;6(11):1133-41
16200068
Clin Exp Immunol. 1990 Aug;81(2):301-5
2117510
FASEB J. 1997 Aug;11(10):743-51
9271359
Am J Gastroenterol. 2004 Aug;99(8):1532-8
15307873
Gastroenterology. 1994 Jun;106(6):1455-66
8194690
Eur J Gastroenterol Hepatol. 2004 Nov;16(11):1167-71
15489577
Lancet. 1992 Jan 11;339(8785):89-91
1345871
Mol Immunol. 1993 Nov;30(16):1443-53
8232330
Gastroenterology. 2006 Mar;130(3):935-9
16530531
Dig Liver Dis. 2002 Sep;34(9):631-4
12405249
Clin Exp Immunol. 1996 Mar;103(3):391-6
8608636
Lancet. 2007 May 12;369(9573):1641-57
17499606
J Immunol. 1999 Jul 15;163(2):1081-90
10395708
Curr Pharm Des. 2004;10(11):1195-205
15078135
Gut. 1997 May;40(5):628-33
9203942
Gut. 2004 Jun;53(6):849-53
15138212
Expert Opin Biol Ther. 2007 Jul;7(7):1051-9
17665993
Inflamm Bowel Dis. 2007 Mar;13(3):308-16
17206708
Annu Rev Immunol. 1992;10:411-52
1590993
Gut. 1975 Aug;16(8):579-84
1183857
Arthritis Rheum. 1993 Dec;36(12):1681-90
8250987
Gut. 2004 Sep;53 Suppl 5:V1-16
15306569
Am J Gastroenterol. 1992 Aug;87(8):971-6
1642220
Gastroenterology. 2007 Feb;132(2):763-86
17258735
Inflamm Bowel Dis. 2001 May;7(2):83-8
11383595
Gastroenterology. 2001 May;120(6):1323-9
11313301
Gastroenterology. 2005 Sep;129(3):1138-9
16143158
Hepatology. 1995 Nov;22(5):1404-8
7590655
Eur J Immunol. 1998 Feb;28(2):730-44
9521083
Gastrointest Endosc. 2002 Jul;56(1):48-54
12085034
Hum Mol Genet. 2002 May 15;11(11):1281-9
12019209
Gut. 2004 Nov;53(11):1556-8
15479669
Cochrane Database Syst Rev. 2005 Jan 25;(1):CD004277
15674937
N Engl J Med. 2005 Dec 8;353(23):2462-76
16339095
Br Med J. 1955 Oct 29;2(4947):1041-8
13260656
Nat Immunol. 2003 Apr;4(4):387-93
12652297
J Clin Invest. 1995 Jan;95(1):55-65
7814646
Tissue Antigens. 2003 Dec;62(6):527-35
14617036
Am J Gastroenterol. 2002 Oct;97(10):2577-84
12385442
Cochrane Database Syst Rev. 2006 Jul 19;(3):CD005112
16856078
Annu Rev Immunol. 2002;20:495-549
11861611
Rev Esp Enferm Dig. 2004 Feb;96(2):94-101
15255018
Gut. 1997 Apr;40(4):443-8
9176068
Clin Ther. 1998 Sep-Oct;20(5):1009-28
9829451
N Engl J Med. 2002 Aug 8;347(6):417-29
12167685
Eur Rev Med Pharmacol Sci. 2004 Sep-Oct;8(5):231-3
15638236
Gut. 1993 Dec;34(12):1705-9
8031350
Aliment Pharmacol Ther. 2007 Jan 1;25(1):19-37
17229218
Gut. 2003 Jul;52(7):998-1002
12801957
Immunol Rev. 2005 Aug;206:260-76
16048554
N Engl J Med. 1987 Dec 24;317(26):1625-9
3317057
Gastroenterol Hepatol. 2004 Aug-Sep;27(7):430-1
15461945
J Immunol. 1997 Dec 15;159(12):6276-82
9550432
Clin Chem. 2001;47(7):1297-301
11427462
Chin Med J (Engl). 2006 Jul 20;119(14):1198-203
16863613
J Clin Pharmacol. 2007 Aug;47(8):930-41
17567930
Nat Rev Immunol. 2003 Jul;3(7):521-33
12876555
Gastroenterology. 2003 Dec;125(6):1576-82
14724807
Nat Med. 2000 May;6(5):583-8
10802717
Science. 1985 Nov 8;230(4726):630-2
2413547