title: Skin prick test reactivity to common aeroallergens and ARIA classification of allergic rhinitis in patients of Central Greece.
abstract: Allergic rhinitis (AR) is prevalent in Mediterranean countries, but there are no epidemiological studies in the Hellenic milieu in accordance with the recent ARIA guidelines. We investigated aetiological aeroallergens in AR patients of Central Greece using the ARIA classification. Between 2002 and 2006, 911 patients with rhinitis symptomatology were interviewed and underwent Skin prick testing and 623 completed the study. Seasonal rhinitis (SAR) represented 37.6%, Perennial rhinitis (PAR) 46.4% and SAR + PAR 16%. Intermittent mild and moderate/severe AR was evident in 9.3 and 24.5%, persistent mild and moderate/severe in 23.2 and 43.0%. Persistent AR appeared in overall 66.2% of patients and was prevalent in PAR and SAR + PAR (p < 0.0001). Severity of AR symptoms did not correlate more with ARIA than with the traditional subgroups. Marked statistical (p < 0.05) differences were evident for seven aeroallergens between the four geographic areas of the study. Pollen allergy was found in 77.8% but all pollens were significantly lower in coastal areas (p < 0.001), besides Parietaria (p < 0.003). Mite sensitivity manifested in 43.2%. Alternaria affected mostly the paediatric population (p < 0.0001). 12.4% (N = 77) was monosensitive, 58.7% (N = 366) oligosensitive, and 28.9% (N = 180) polysensitive. Rhinitis and asthma comorbidity was high (45.3%) and occurrence of asthma was related with PAR (p < 0.007) and SAR + PAR (p < 0.023) but not with the ARIA classification subgroups. This study provides compelling evidence of a typical Mediterranean allergic profile of patients of Central Greece with significant regional variability. Both classifications had approximately equal diagnostic value in our study besides the fact that ARIA subdivision is considered superior in determining treatment.
authors.affiliation: Department of Otorhinolaryngology, "G. Gennimatas" General Hospital, Athens, Greece.
authors.forename: K  K
authors.initials: K
authors.lastname: Anastassakis
authors.forename: A
authors.initials: A
authors.lastname: Chatzimichail
authors.forename: I
authors.initials: I
authors.lastname: Androulakis
authors.forename: S
authors.initials: S
authors.lastname: Charisoulis
authors.forename: Maria
authors.initials: M
authors.lastname: Riga
authors.forename: Anna
authors.initials: A
authors.lastname: Eleftheriadou
authors.forename: V
authors.initials: V
authors.lastname: Danielides
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000485:Allergens / Q000276:immunology*; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006115:Greece / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011058:Pollen / Q000276:immunology*; D015995:Prevalence; D015203:Reproducibility of Results; D012189:Retrospective Studies; D006255:Rhinitis, Allergic, Seasonal / Q000145:classification* / Q000175:diagnosis / Q000453:epidemiology; D012882:Skin Tests / Q000379:methods*; D055815:Young Adult
chemical_list: D000485:Allergens
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