title: Comparison of plasma clearance of exogenous creatinine, exo-iohexol, and endo-iohexol over a range of glomerular filtration rates expected in cats.
abstract: The study investigated plasma clearance of exogenous creatinine (PECCT), exo-iohexol (PexICT) and endo-iohexol (PenICT) in six healthy cats, four cats with chronic kidney disease (CKD) and six hyperthyroid (HT) cats to assess potential differences in glomerular filtration rate (GFR) measurement over a wide range of GFR values. The PECCT, PexICT and PenICT were performed in a combined protocol. There was a significant difference between PexICT and PenICT and PECCT in healthy cats. Differences between clearance techniques are suggested to be correlated to range in GFRs and should be taken into account when GFR is measured.
authors.affiliation: Department of Medicine and Clinical Biology of Small Animals, Faculty of Veterinary Medicine, University of Ghent, Salisburylaan 133, 9820 Merelbeke, Belgium.
authors.forename: Ingrid M
authors.initials: IM
authors.lastname: van Hoek
authors.forename: Hervé P
authors.initials: HP
authors.lastname: Lefebvre
authors.forename: Dominique
authors.initials: D
authors.lastname: Paepe
authors.forename: Siska
authors.initials: S
authors.lastname: Croubels
authors.forename: Vincent
authors.initials: V
authors.lastname: Biourge
authors.forename: Sylvie
authors.initials: S
authors.lastname: Daminet
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D002371:Cat Diseases / Q000378:metabolism* / Q000532:radiotherapy; D002415:Cats / Q000097:blood*; D003404:Creatinine / Q000493:pharmacokinetics*; D005260:Female; D005919:Glomerular Filtration Rate / Q000662:veterinary*; D006980:Hyperthyroidism / Q000378:metabolism / Q000532:radiotherapy / Q000662:veterinary*; D007455:Iodine / Q000627:therapeutic use; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D007472:Iohexol / Q000493:pharmacokinetics*; D007674:Kidney Diseases / Q000175:diagnosis / Q000662:veterinary*; D008297:Male; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D012016:Reference Values
chemical_list: D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D007472:Iohexol; D007455:Iodine; D003404:Creatinine
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