title: Total-tau and phospho-tau(181Thr) in cerebrospinal fluid of neurologically intact population increase with age.
abstract: Tau protein is a microtubule-associated molecule playing a crucial role in maintenance of neuronal integrity and in many neurodegenerative processes; its pathology has become a hallmark feature at the tissue level. The aim of the study was to estimate total tau and phospho-tau (Thr181) concentrations in cerebrospinal fluid of healthy population. Cerebrospinal fluid samples were taken from 129 subjects (age 18-77 years) without known neurologic or psychiatric condition. Both total-tau and phospho-tau levels showed significant correlation with age, which was more pronounced in older population.
authors.affiliation: Department of Neurology, Medical University of Lublin, Lublin, Poland. jjawor@onet.eu
authors.forename: J
authors.initials: J
authors.lastname: Jaworski
authors.forename: M
authors.initials: M
authors.lastname: Psujek
authors.forename: H
authors.initials: H
authors.lastname: Bartosik-Psujek
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D000375:Aging / Q000134:cerebrospinal fluid*; D016001:Confidence Intervals; D005260:Female; D006262:Health; D006801:Humans; D008297:Male; D008875:Middle Aged; D010750:Phosphoproteins / Q000134:cerebrospinal fluid*; D012044:Regression Analysis; D055815:Young Adult; D016875:tau Proteins / Q000134:cerebrospinal fluid*
chemical_list: D010750:Phosphoproteins; D016875:tau Proteins