title: Two different mechanisms control ethylene sensitivity in Arabidopsis via the regulation of EBF2 expression.
abstract: EIN3 is a key transcription factor in the ethylene signaling pathway in Arabidopsis and its action is controlled by SCFEBF1/2 complex-mediated ubiquitination and subsequent 26S proteasome-dependent degradation. Our recent study revealed that ethylene signaling is regulated by a negative feedback system involving the direct activation of the EBF2 promoter by EIN3. This negative feedback loop likely modulates both the magnitude of the response to ethylene and the recovery after its withdrawal. The sequence downstream of the EBF2 stop codon was also found to play a role in determining the EBF2 expression levels independently of ethylene signaling. The reduction in EBF2 expression via the function of this sequence was suggested to be important for coupling the EBF2 expression levels to growth control. Two different mechanisms thus appear to be involved in determining ethylene sensitivity in Arabidopsis.
authors.affiliation: Department of Applied Biological Chemistry; Graduate School of Agricultural and Life Sciences; The University of Tokyo; Bunkyo-ku, Tokyo Japan.
authors.forename: Mineko
authors.initials: M
authors.lastname: Konishi
authors.forename: Shuichi
authors.initials: S
authors.lastname: Yanagisawa
references.citation: Proc Natl Acad Sci U S A. 2000 Dec 5;97(25):13985-90
references.pmid: 11106401
references.citation: Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):11513-8
references.pmid: 12167669
references.citation: Cell. 2003 Dec 12;115(6):667-77
references.pmid: 14675532
references.citation: Proc Natl Acad Sci U S A. 2006 Sep 5;103(36):13286-93
references.pmid: 16920797
references.citation: Nat Rev Mol Cell Biol. 2006 Jun;7(6):415-25
references.pmid: 16723977
references.citation: Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6803-8
references.pmid: 15090654
references.citation: Plant J. 2008 Sep;55(5):821-31
references.pmid: 18466304
references.citation: Plant Cell. 2006 Nov;18(11):3047-57
references.pmid: 17085683
references.citation: Curr Opin Plant Biol. 2004 Feb;7(1):40-9
references.pmid: 14732440
references.citation: Plant Cell. 2007 Nov;19(11):3418-36
references.pmid: 18024567
references.citation: Annu Rev Cell Dev Biol. 2000;16:1-18
references.pmid: 11031228
references.citation: Mol Cell. 2004 Jul 23;15(2):173-83
references.pmid: 15260969
references.citation: Plant Cell. 2007 Feb;19(2):509-23
references.pmid: 17307926
references.citation: Cell. 2003 Dec 12;115(6):679-89
references.pmid: 14675533
references.citation: Nature. 2003 Oct 2;425(6957):521-5
references.pmid: 14523448