The surgical treatment of Landau-Kleffner syndrome.
The medical management of Landau-Kleffner syndrome is usually effective for seizure control and eventual seizure remission. However, the response for language and behavior is often poor. Surgery, in the form of multiple subpial transections (MSTs) to include Wernicke's area has been suggested as a way forward if electrophysiologic lateralization can be demonstrated. Surgical series in the literature are few and outcome from surgery variable.
Cross
J Helen
JH
UCL-Institute of Child Health, Great Ormond Street Hospital for Children & National Centre for Young People with Epilepsy, London, United Kingdom. hcross@ich.ucl.ac.uk
Neville
Brian G R
BG
D000293:Adolescent; D000377:Agnosia / Q000601:surgery; D002540:Cerebral Cortex / Q000503:physiopathology / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D004569:Electroencephalography; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D018887:Landau-Kleffner Syndrome / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D007805:Language Development Disorders / Q000503:physiopathology / Q000601:surgery; D010841:Pia Mater / Q000601:surgery; D012640:Seizures / Q000601:surgery; D013702:Temporal Lobe / Q000601:surgery; D016896:Treatment Outcome