title: Non-invasive assessment of left ventricular relaxation during atrial fibrillation using mitral flow propagation velocity.
abstract: OBJECTIVE
  To elucidate the usefulness of the early diastolic mitral flow propagation velocity (V(p)) obtained from colour M-mode Doppler for non-invasively assessing left-ventricular (LV) relaxation during atrial fibrillation (AF).
  
  
  RESULTS
  Ten healthy adult dogs were studied to correlate V(p) with the invasive minimum value of the first derivative of LV pressure decay (dP/dt(min)) and the time constant of isovolumic LV pressure decay (tau) at baseline, during rapid and slow AF, and during AF after inducing myocardial infarction. There were significant positive and negative curvilinear relationships between V(p) and dP/dt(min) and tau, respectively, during rapid AF. After slowing the ventricular rate, the average value of V(p) increased, while dP/dt(min) increased and tau decreased. After inducing myocardial infarction, the average value of V(p) decreased, while dP/dt(min) decreased and tau increased.
  
  
  CONCLUSIONS
  The non-invasively obtained V(p) evaluates LV relaxation even during AF regardless of ventricular rhythm or the presence of pathological changes.
authors.affiliation: Section of Cardiovascular Imaging, Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA.
authors.forename: Junko
authors.initials: J
authors.lastname: Asada-Kamiguchi
authors.forename: Tomotsugu
authors.initials: T
authors.lastname: Tabata
authors.forename: Zoran B
authors.initials: ZB
authors.lastname: Popovic
authors.forename: Neil L
authors.initials: NL
authors.lastname: Greenberg
authors.forename: Yong Jin
authors.initials: YJ
authors.lastname: Kim
authors.forename: Mario J
authors.initials: MJ
authors.lastname: Garcia
authors.forename: Don W
authors.initials: DW
authors.lastname: Wallick
authors.forename: Kent A
authors.initials: KA
authors.lastname: Mowrey
authors.forename: Shaowei
authors.initials: S
authors.lastname: Zhuang
authors.forename: Youhua
authors.initials: Y
authors.lastname: Zhang
authors.forename: Todor N
authors.initials: TN
authors.lastname: Mazgalev
authors.forename: James D
authors.initials: JD
authors.lastname: Thomas
authors.forename: Richard A
authors.initials: RA
authors.lastname: Grimm
mesh_terms: D000818:Animals; D001281:Atrial Fibrillation / Q000000981:diagnostic imaging / Q000503:physiopathology*; D001783:Blood Flow Velocity; D003971:Diastole; D004285:Dogs; D018618:Echocardiography, Doppler, Color; D008943:Mitral Valve / Q000000981:diagnostic imaging / Q000503:physiopathology*; D009126:Muscle Relaxation / Q000502:physiology*; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging / Q000503:physiopathology*; D016277:Ventricular Function, Left / Q000502:physiology*
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