title: Highly regioselective Au(I)-catalyzed hydroamination of ynamides and propiolic acid derivatives with anilines.
abstract: A highly regioselective hydroamination of unsymmetrical electron-poor and electron-rich alkynes with anilines catalyzed by Au(I) under mild conditions is reported. In addition, applications toward indole syntheses are presented including an example of a one-pot synthesis from a nonfunctionalized aniline.
authors.affiliation: Center for Insoluble Protein Structures (inSPIN), Department of Chemistry and the Interdisciplinary Nanoscience Center, Aarhus University, Langelandsgade 140, 8000 Aarhus C, Denmark.
authors.forename: Søren
authors.initials: S
authors.lastname: Kramer
authors.forename: Karin
authors.initials: K
authors.lastname: Dooleweerdt
authors.forename: Anders Thyboe
authors.initials: AT
authors.lastname: Lindhardt
authors.forename: Mario
authors.initials: M
authors.lastname: Rottländer
authors.forename: Troels
authors.initials: T
authors.lastname: Skrydstrup
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D000814:Aniline Compounds / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D006046:Gold / Q000737:chemistry*; D015394:Molecular Structure; D011422:Propionates / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000480:Alkynes; D000814:Aniline Compounds; D011422:Propionates; D006046:Gold; C011537:propiolic acid; C023650:aniline