Experimental comparison of meshes for rectal prolapse surgery.
OBJECTIVE
The aim of this experimental study is to investigate the foreign body tissue created by the meshes that are used for rectopexy.


METHODS
Sixty rats were divided equally into 5 groups. Four mesh types (Surgipro, Ivalon, Gore-Tex and Vypro) were implanted into the retroperitoneal area except for the sham group. After a 5-week follow-up period, all animals were sacrificed. Specimens were evaluated macroscopically by using scoring systems and biochemically by determining tissue hydroxyproline and nitric oxide levels.


RESULTS
The most evident foreign body reaction was observed in the Ivalon group, which showed higher 'macroscopic adhesion' scores (p < 0.005), although there were no significant differences in tissue hydroxyproline and nitric oxide levels between the groups (p > 0.05).


CONCLUSIONS
In rectal prolapse surgery, selecting the ideal mesh type is unclear, depending on evidence-based results. In the present study, we could not prove which mesh was definitely superior to the other, macroscopically, histologically and biochemically. The findings of this experimental rat model suggest that implantation of all 4 types of meshes are suitable for posterior rectopexy.
Calişkan
Cemil
C
Division of Proctology, Department of General Surgery, Ege University School of Medicine, Bornova, Izmir, Turkey. cemil.caliskan@ege.edu.tr
Denizli
A
A
Makay
O
O
Firat
O
O
Tanyalcin
T
T
Alkanat
M
M
Korkut
M A
MA
D000818:Animals; D005549:Foreign-Body Reaction / Q000209:etiology* / Q000378:metabolism; D006909:Hydroxyproline / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012005:Rectal Prolapse / Q000601:surgery*; D013526:Surgical Mesh / Q000009:adverse effects*
D009569:Nitric Oxide; D006909:Hydroxyproline