Assessment of preoperative serum prolidase activity in epithelial ovarian cancer.
OBJECTIVE
Prolidase is a cytosolic exopeptidase that cleaves iminodipeptides with C-terminal proline and hydroxyproline and plays a major role in collagen turnover. The aim of this study was to evaluate preoperative serum prolidase activity, total oxidant status (TOS), and total antioxidant capacity (TAC) in patients with newly diagnosed epithelial ovarian cancer (EOC).


METHODS
Serum prolidase activity, TOS, and TAC were measured spectrophotometrically in both EOC cases (n=28) and controls (n=28).


RESULTS
Preoperative serum prolidase activity and TOS were significantly higher in patients with EOC compared to controls (p=0.009 and 0.008, respectively), whereas TAC was significantly lower in cases (p<0.001). A significant positive correlation was found between the stage, grade, and CA-125 level of EOC and serum prolidase activity (rho=0.466, p=0.012; rho=0.501, p=0.007; and rho=0.447, p=0.017, respectively) and TOS (rho=0.588, p=0.001; rho=0.412, p=0.029; and rho=0.568, p=0.002, respectively). In contrast, there was a negative correlation between TAC and the stage, grade, and CA-125 level of EOC (rho=-0.555, p=0.002; rho=-0.566, p=0.002; and rho=-0.581, p=0.001, respectively).


CONCLUSIONS
Findings of the present study demonstrate that serum prolidase activity is significantly associated with the stage, tumor grade, and preoperative CA-125 level of EOC.
Camuzcuoglu
Hakan
H
Faculty of Medicine, Department of Obstetrics and Gynecology, Harran University, Sanliurfa, Turkey. hakancamuzcuoglu@gmail.com
Arioz
Dagistan Tolga
DT
Toy
Harun
H
Kurt
Sefa
S
Celik
Hakim
H
Aksoy
Nurten
N
D000328:Adult; D000975:Antioxidants / Q000378:metabolism; D018394:CA-125 Antigen / Q000097:blood; D016022:Case-Control Studies; D004150:Dipeptidases / Q000097:blood*; D018450:Disease Progression; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D009375:Neoplasms, Glandular and Epithelial / Q000097:blood* / Q000473:pathology*; D010051:Ovarian Neoplasms / Q000097:blood* / Q000473:pathology*; D016877:Oxidants / Q000378:metabolism; D011237:Predictive Value of Tests; D057234:Preoperative Period; D013053:Spectrophotometry
D000975:Antioxidants; D018394:CA-125 Antigen; D016877:Oxidants; D004150:Dipeptidases; C022449:proline dipeptidase