Mylip makes an Idol turn into regulation of LDL receptor.
High blood low-density-lipoprotein (LDL) cholesterol is a serious health problem among an increased number of patients in the Western world. Statins and other cholesterol lowering drugs have proven to be beneficial as therapy but are not optimal and show adverse effects in some patients. The LDL receptor is a crucial determinant of cholesterol metabolism in the body and amenable for drug interventions. Novel insights into the physiology of this receptor come from studies on the ubiquitination and degradation of LDL receptor by the ubiquitin ligase Mylip/Idol that is induced in cells by the nuclear receptor, LXR. This may open up new possibilities in the future to influence LDL receptor levels and cholesterol metabolism pharmacologically in various diseases.
Lindholm
Dan
D
Minerva Medical Research Institute, Biomedicum-2, Helsinki University, Stockholmsgatan 8, 00290 Helsinki, Finland. dan.lindholm@helsinki.fi
Bornhauser
Beat C
BC
Korhonen
Laura
L
D000818:Animals; D008078:Cholesterol, LDL / Q000378:metabolism; D006801:Humans; D000071518:Liver X Receptors; D053858:Metabolic Networks and Pathways / Q000502:physiology; D057093:Orphan Nuclear Receptors / Q000378:metabolism / Q000502:physiology; D011499:Protein Processing, Post-Translational / Q000502:physiology*; D011973:Receptors, LDL / Q000378:metabolism*; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism / Q000502:physiology*; D054875:Ubiquitination / Q000502:physiology
D008078:Cholesterol, LDL; D000071518:Liver X Receptors; D057093:Orphan Nuclear Receptors; D011973:Receptors, LDL; C403126:MYLIP protein, human; D044767:Ubiquitin-Protein Ligases
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