title: Body mass index is negatively correlated with respiratory muscle weakness and interleukin-6 production after coronary artery bypass grafting.
abstract: OBJECTIVE
  The present study was performed to clarify the relationships between body mass index (BMI), interleukin-6 (IL-6) production, and respiratory muscle weakness in patients undergoing coronary artery bypass grafting (CABG).
  
  
  METHODS
  The correlations among BMI, changes in maximum inspiratory and expiratory pressure (DeltaMIP, DeltaMEP) on postoperative days (POD) 1 and 7, postoperative IL-6, and rapid turnover proteins (retinol-binding protein, prealbumin, and transferrin) on POD1 were assessed in 154 consecutive patients undergoing elective CABG. The patients were divided into quartiles of BMI, Q1 (BMI, <20.8 kg/m(2)) to Q4 (BMI, > or =25.25 kg/m(2)), and compared among groups.
  
  
  RESULTS
  There were significant correlations between DeltaMIP and BMI (POD1, r = -0.369; POD7, r = -0.285) and IL-6 (POD1, r = 0.423; POD7, r = 0.431), and between DeltaMEP and BMI (POD1, r = -0.252; POD7, r = -0.228) and IL-6 (POD1, r = 0.252; POD7, r = 0.384). Interleukin-6 showed a significant negative correlation with BMI (r = -0.374) and retinol-binding protein (r = -0.382). Interleukin-6 was highest in Q1 and lowest in Q4. Higher BMI indicated greater respiratory muscle strength than lower BMI.
  
  
  CONCLUSIONS
  Preoperative BMI is correlated with respiratory muscle strength and cytokine production after CABG. The findings of this study suggest that BMI may be a valuable predictor for respiratory management in CABG patients.
authors.affiliation: Department of Physiotherapy, Kainan Hospital, Yatomi, Aichi, Japan. y2iida@na.commufa.jp
authors.forename: Yuki
authors.initials: Y
authors.lastname: Iida
authors.forename: Sumio
authors.initials: S
authors.lastname: Yamada
authors.forename: Osamu
authors.initials: O
authors.lastname: Nishida
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Nakamura
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D015992:Body Mass Index; D001026:Coronary Artery Bypass; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000096:biosynthesis* / Q000097:blood; D008297:Male; D008875:Middle Aged; D018908:Muscle Weakness / Q000209:etiology / Q000503:physiopathology*; D011183:Postoperative Complications / Q000209:etiology; D011237:Predictive Value of Tests; D012129:Respiratory Function Tests; D015656:Respiratory Mechanics; D012132:Respiratory Muscles / Q000503:physiopathology*; D012177:Retinol-Binding Proteins / Q000032:analysis
chemical_list: D015850:Interleukin-6; D012177:Retinol-Binding Proteins