Running GAGs: myxoid matrix in tumor pathology revisited: what's in it for the pathologist?
Ever since Virchow introduced the entity myxoma, abundant myxoid extracellular matrix (ECM) has been recognized in various reactive and neoplastic lesions. Nowadays, the term "myxoid" is commonly used in daily pathological practice. But what do today's pathologists mean by it, and what does the myxoid ECM tell the pathologist? What is known about the exact composition and function of the myxoid ECM 150 years after Virchow? Here, we give an overview of the composition and constituents of the myxoid ECM as known so far and demonstrate the heterogeneity of the myxoid ECM among different tumors. We discuss the possible role of the predominant constituents of the myxoid ECM and attempt to relate them to differences in clinical behavior. Finally, we will speculate on the potential relevance of this knowledge in daily pathological practice.
Willems
Stefan M
SM
Department of Pathology, Leiden University Medical Center, L1Q, Leiden, The Netherlands.
Wiweger
Malgorzata
M
van Roggen
J Frans Graadt
JF
Hogendoorn
Pancras C W
PC
D005109:Extracellular Matrix / Q000378:metabolism* / Q000473:pathology; D005354:Fibrosarcoma / Q000378:metabolism / Q000473:pathology; D006025:Glycosaminoglycans / Q000378:metabolism*; D006801:Humans; D009232:Myxoma / Q000378:metabolism / Q000473:pathology; D012509:Sarcoma / Q000378:metabolism* / Q000473:pathology
D006025:Glycosaminoglycans
Bioessays. 2007 Aug;29(8):758-71
17621645
Dermatologica. 1956 Oct;113(4):219-25
13384067
Am J Surg Pathol. 1990 Sep;14(9):801-9
2167613
Dev Dyn. 2008 Oct;237(10):2622-42
18629873
Curr Opin Cell Biol. 2006 Oct;18(5):463-71
16919434
J Cell Biol. 1997 Feb 10;136(3):729-43
9024701
Am J Surg Pathol. 2000 Jul;24(7):927-36
10895815
Am J Pathol. 2001 Apr;158(4):1465-72
11290564
J Biol Chem. 1997 Aug 15;272(33):20414-9
9252349
J Biol Chem. 2008 Aug 1;283(31):21305-9
18463092
Am J Clin Pathol. 2001 Aug;116(2):271-7
11488075
Acta Neuropathol. 1982;57(4):299-305
7136509
Q J Microsc Sci. 1950 Dec;91(4):477-9
24540170
J Am Coll Cardiol. 2002 Dec 18;40(12):2072-81
12505216
Am J Dermatopathol. 1995 Feb;17(1):36-41
7535018
J Cutan Pathol. 2006 Mar;33(3):227-30
16466510
J Pathol. 2003 Jul;200(4):423-8
12845610
J Cell Mol Med. 2009 Jul;13(7):1291-301
19320777
Cell Mol Life Sci. 2007 Jul;64(13):1591-6
17502996
Hum Pathol. 1985 Jun;16(6):621-8
3997139
J Struct Biol. 2006 Aug;155(2):294-305
16884925
Mod Pathol. 2008 Oct;21(10):1282-92
18622387
Dermatology. 2002;205(2):122-6
12218225
Virchows Arch. 2005 Nov;447(5):828-34
16021506
Dev Dyn. 2000 Jun;218(2):235-59
10842355
Arterioscler Thromb Vasc Biol. 1999 Apr;19(4):1004-13
10195929
Cancer. 1977 Apr;39(4):1672-85
192434
Ann Diagn Pathol. 2000 Aug;4(4):207-17
10982298
Lancet Oncol. 2009 May;10(5):508-15
19410195
Br J Cancer. 1991 Aug;64(2):307-14
1909886
Am J Dermatopathol. 1998 Feb;20(1):41-7
9504668
Am J Physiol Regul Integr Comp Physiol. 2007 Oct;293(4):R1552-60
17699562
Pathol Int. 1994 Jun;44(6):448-53
8055111
J Cutan Pathol. 2008 Feb;35(2):186-91
18190443
J Biol Chem. 2005 Nov 18;280(46):38537-43
16129687
Acta Orthop Scand. 1990 Apr;61(2):99-105
2193480
Histochemie. 1965 Oct 1;5(3):221-33
4223499
J Cancer Res Clin Oncol. 2000 Jun;126(6):320-4
10870641
Am J Surg Pathol. 1994 Jul;18(7):668-76
8017561
J Cell Physiol. 2001 Dec;189(3):266-74
11748584
Pathol Int. 2001 Apr;51(4):248-56
11350606
J Pathol. 2009 Apr;217(5):716-27
19199331
J Cell Biol. 1994 Mar;124(5):817-25
8120102
Cytogenet Cell Genet. 1996;72(2-3):171-4
8978765
Ultrastruct Pathol. 1984;6(1):69-81
6203201
Am J Surg Pathol. 1996 Apr;20(4):391-405
8604805
Exp Cell Res. 1996 Dec 15;229(2):388-97
8986622
Mod Pathol. 2004 Feb;17(2):214-21
14657948
Dermatology. 2003;207(1):104-6
12835568
Genes Chromosomes Cancer. 2005 Oct;44(2):204-11
16001434
Am J Clin Pathol. 2009 May;131(5):701-9
19369631
Am J Vet Res. 2005 Aug;66(8):1408-14
16173485
Matrix Biol. 2006 Oct;25(8):484-91
16979885
Acta Neuropathol. 1985;68(1):80-2
3931407
JAMA. 1965 Jan 4;191:15-20
14222964
Pathol Res Pract. 1999;195(6):391-7
10399179
J Pathol. 2004 Aug;203(4):953-60
15258999
J Cell Sci. 2005 Apr 1;118(Pt 7):1341-53
15788652
Ann Thorac Surg. 2004 Feb;77(2):532-6
14759433
Cancer. 1975 Sep;36(3):985-94
241481
Dev Dyn. 2003 Feb;226(2):268-79
12557205
Am J Surg Pathol. 1981 Jul;5(5):443-58
6269445
Histopathology. 2008 Mar;52(4):465-74
18315599
Mod Pathol. 2004 Apr;17(4):482-8
14976536
Mod Pathol. 2006 Mar;19(3):407-16
16415793
Curr Opin Cell Biol. 2002 Oct;14(5):617-23
12231358
Curr Opin Cell Biol. 2008 Oct;20(5):495-501
18640274
Ann Surg. 1948 May;127(4):706-19
18917127
Int J Gynecol Pathol. 1996 Oct;15(4):320-5
8886879
J Cell Physiol. 2007 Dec;213(3):565-73
17680633
Presse Med. 1967 Oct 25;75(44):2223-8
6054147
Chem Biol Drug Des. 2008 Dec;72(6):455-82
19090915
Curr Opin Cell Biol. 2007 Oct;19(5):578-83
17942296
Hum Pathol. 1972 Sep;3(3):421-35
4261659
Am J Surg Pathol. 2003 Apr;27(4):421-31
12657926
J Pathol. 2008 Sep;216(1):1-14
18680111
Jpn J Clin Oncol. 1991 Dec;21(6):447-52
1805049
Cancer Genet Cytogenet. 1986 Dec;23(4):291-9
3779625
J Pathol. 2003 Jul;200(4):429-47
12845611
J Bone Joint Surg Am. 1952 Oct;34 A(4):820-6
12990622
J Biol Chem. 2007 Dec 7;282(49):35887-98
17942398
Am J Surg Pathol. 1993 Jun;17(6):595-600
8333558
Acta Pathol Microbiol Scand A. 1977 Mar;85A(2):127-40
15396
Histopathology. 1999 Oct;35(4):291-312
10564384
Medicine (Baltimore). 1985 Jul;64(4):270-83
4010501
Am J Clin Pathol. 1980 Dec;74(6):759-64
7446487
Cancer Lett. 2006 Dec 8;244(2):143-63
16632194