Comparison of Oxiplex and Gore-Tex effectivity in an experimental peridural fibrosis model.
OBJECTIVE
The authors conducted a study to compare the effectiveness of Oxiplex and Gore-tex in preventing postlaminectomy peridural fibrosis in rats. Peridural fibrosis is a common cause of pain in patients undergoing spinal surgery. To prevent scar formation numerous materials and methods have been employed such as non steroidal anti-inflammatory drugs (NSAIDs), Gelfoam, Oxiplex, Gore-tex, carboxymethil cellulose, Adcon-L, autogenous adipose grefting, mitomisin, and radiotherapy have been investigating for a long time, but only moderate success has been obtained.


METHODS
Laminectomies were performed at the fourth lumbar vertebra (L-4) in 30 rats. Oxiplex or Gore-Tex was applied over the dura mater with the aim to perform a blinded evaluation of their effects. In the control group, only a L-4 laminectomy was performed. Animals were sacrificed 28 days after the surgical procedure. The extent of peridural fibrosis was evaluated on spine specimens by histological analysis.


RESULTS
Both groups of animals treated with either Oxiplex or Gore-Tex showed a significant reduction in the degree of peridural fibrosis as compared to the control group. However no significant difference in the prevention of peridural fibrosis was observed between the Oxiplex and Gore-Tex groups.


CONCLUSIONS
This experimental model has shown that Oxiplex and Gore-Tex are effective methods to prevent peridural fibrosis and dural adhesions at the postlaminectomy areas.
Kurt
G
G
Departments of Neurosurgery, Gazi University School of Medicine, Ankara, Turkey.
Cemil
B
B
Celik
B
B
Durdag
E
E
Erdem
O
O
Ceviker
N
N
D000818:Animals; D002482:Cellulose / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002921:Cicatrix / Q000473:pathology / Q000517:prevention & control*; D004388:Dura Mater / Q000473:pathology*; D055111:Failed Back Surgery Syndrome / Q000209:etiology / Q000517:prevention & control; D005355:Fibrosis; D007796:Laminectomy; D008159:Lumbar Vertebrae / Q000601:surgery; D008297:Male; D008422:Materials Testing; D011092:Polyethylene Glycols / Q000627:therapeutic use*; D011138:Polytetrafluoroethylene / Q000627:therapeutic use*; D011183:Postoperative Complications / Q000473:pathology / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar; D013526:Surgical Mesh; D000267:Tissue Adhesions / Q000473:pathology / Q000517:prevention & control*
C406630:Oxiplex; D011092:Polyethylene Glycols; D011138:Polytetrafluoroethylene; D002482:Cellulose