title: (+)-N-(2-hydroxypropyl)lindcarpine: a new cytotoxic aporphine isolated from Actinodaphne pruinosa Nees.
abstract: Onenewalkaloid; (+)-N-(2-hydroxypropyl)lindcarpine (1),together with four known aporphine alkaloids, (+)-boldine (2) (+)-norboldine (3), (+)-lindcarpine (4) and (+)-methyllindcarpine (5) were isolated from the stem bark of Actinodaphne pruinosa Nees (Lauraceae). (+)-N-(2-Hydroxypropyl)lindcarpine (1) exhibited cytotoxic activity against P-388 murine leukemia cells with an IC(50 )value of 3.9 microg/mL. Structural elucidation of all the compounds were performed by spectral methods such as 1D- and 2D- NMR, IR, UV, and HRESIMS.
authors.affiliation: Department of Chemistry, Faculty of Science and Mathematic, University of Indonesia, Depok, Indonesia. tiahrachmatiah@yahoo.com
authors.forename: Tiah
authors.initials: T
authors.lastname: Rachmatiah
authors.forename: Mat Ropi
authors.initials: MR
authors.lastname: Mukhtar
authors.forename: Mohd Azlan
authors.initials: MA
authors.lastname: Nafiah
authors.forename: Muhammad
authors.initials: M
authors.lastname: Hanafi
authors.forename: Soleh
authors.initials: S
authors.lastname: Kosela
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Morita
authors.forename: Marc
authors.initials: M
authors.lastname: Litaudon
authors.forename: Khalijah
authors.initials: K
authors.lastname: Awang
authors.forename: Hanita
authors.initials: H
authors.lastname: Omar
authors.forename: A Hamid A
authors.initials: AH
authors.lastname: Hadi
mesh_terms: D000818:Animals; D001060:Aporphines / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003603:Cytotoxins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D019770:Lauraceae / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D015394:Molecular Structure; D018547:Plant Stems / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet
chemical_list: D001060:Aporphines; D003603:Cytotoxins; C081279:aporphine
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