title: Cortico-Basal Ganglia reward network: microcircuitry.
abstract: Many of the brain's reward systems converge on the nucleus accumbens, a region richly innervated by excitatory, inhibitory, and modulatory afferents representing the circuitry necessary for selecting adaptive motivated behaviors. The ventral subiculum of the hippocampus provides contextual and spatial information, the basolateral amygdala conveys affective influence, and the prefrontal cortex provides an integrative impact on goal-directed behavior. The balance of these afferents is under the modulatory influence of dopamine neurons in the ventral tegmental area. This midbrain region receives its own complex mix of excitatory and inhibitory inputs, some of which have only recently been identified. Such afferent regulation positions the dopamine system to bias goal-directed behavior based on internal drives and environmental contingencies. Conditions that result in reward promote phasic dopamine release, which serves to maintain ongoing behavior by selectively potentiating ventral subicular drive to the accumbens. Behaviors that fail to produce an expected reward decrease dopamine transmission, which favors prefrontal cortical-driven switching to new behavioral strategies. As such, the limbic reward system is designed to optimize action plans for maximizing reward outcomes. This system can be commandeered by drugs of abuse or psychiatric disorders, resulting in inappropriate behaviors that sustain failed reward strategies. A fuller appreciation of the circuitry interconnecting the nucleus accumbens and ventral tegmental area should serve to advance discovery of new treatment options for these conditions.
authors.affiliation: Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260,USA. sesack@pitt.edu
authors.forename: Susan R
authors.initials: SR
authors.lastname: Sesack
authors.forename: Anthony A
authors.initials: AA
authors.lastname: Grace
mesh_terms: D000818:Animals; D001479:Basal Ganglia / Q000033:anatomy & histology / Q000502:physiology*; D002540:Cerebral Cortex / Q000033:anatomy & histology / Q000502:physiology*; D006801:Humans; D008959:Models, Neurological; D009434:Neural Pathways / Q000033:anatomy & histology / Q000502:physiology; D009714:Nucleus Accumbens / Q000033:anatomy & histology / Q000502:physiology; D012201:Reward; D017557:Ventral Tegmental Area / Q000033:anatomy & histology / Q000502:physiology
references.citation: Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):13189-93
references.pmid: 12237410
references.citation: Brain Res. 1996 Nov 18;740(1-2):151-61
references.pmid: 8973809
references.citation: J Comp Neurol. 1988 Jun 1;272(1):1-14
references.pmid: 2898489
references.citation: Neuroscience. 2003;119(1):19-31
references.pmid: 12763065
references.citation: Neuron. 2005 Jun 2;46(5):703-13
references.pmid: 15924857
references.citation: J Neurophysiol. 2004 Mar;91(3):1111-21
references.pmid: 14573550
references.citation: J Comp Neurol. 2001 May 21;434(1):29-39
references.pmid: 11329127
references.citation: J Neurosci. 2004 Apr 7;24(14):3554-62
references.pmid: 15071103
references.citation: Science. 1990 Dec 7;250(4986):1429-32
references.pmid: 2147780
references.citation: Hippocampus. 1996;6(5):495-512
references.pmid: 8953303
references.citation: J Neurosci. 2001 Jul 1;21(13):4915-22
references.pmid: 11425919
references.citation: J Comp Neurol. 1992 Feb 15;316(3):314-47
references.pmid: 1577988
references.citation: Nature. 2005 Sep 22;437(7058):556-9
references.pmid: 16100511
references.citation: J Comp Neurol. 1994 Jul 22;345(4):579-95
references.pmid: 7962701
references.citation: Synapse. 2007 Feb;61(2):87-95
references.pmid: 17117419
references.citation: Philos Trans R Soc Lond B Biol Sci. 2008 Oct 12;363(1507):3125-35
references.pmid: 18640910
references.citation: J Chem Neuroanat. 1996 Feb;10(1):19-39
references.pmid: 8703362
references.citation: Neuroscience. 1988 Oct;27(1):1-39
references.pmid: 3059226
references.citation: J Comp Neurol. 1989 Dec 8;290(2):213-42
references.pmid: 2592611
references.citation: Neuron. 2005 Jul 21;47(2):255-66
references.pmid: 16039567
references.citation: J Comp Neurol. 1966 Mar;126(3):311-35
references.pmid: 4957032
references.citation: Neuron. 2009 Mar 12;61(5):786-800
references.pmid: 19285474
references.citation: Eur J Neurosci. 1993 Feb 1;5(2):137-44
references.pmid: 8261095
references.citation: J Comp Neurol. 1995 Nov 20;362(3):400-10
references.pmid: 8576447
references.citation: J Comp Neurol. 1993 Aug 22;334(4):603-17
references.pmid: 8408768
references.citation: Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5167-72
references.pmid: 16549786
references.citation: Neuroscience. 1995 Feb;64(4):1019-34
references.pmid: 7753373
references.citation: Behav Brain Res. 2000 Jun 1;110(1-2):73-81
references.pmid: 10802305
references.citation: Ann N Y Acad Sci. 1988;537:27-50
references.pmid: 2462395
references.citation: Neuroscience. 1996 Mar;71(2):371-82
references.pmid: 9053793
references.citation: Drug Alcohol Depend. 1995 Feb;37(2):95-100
references.pmid: 7758408
references.citation: Brain Res. 1998 Jun 22;797(1):73-93
references.pmid: 9630528
references.citation: J Neurosci. 2006 Mar 8;26(10):2788-97
references.pmid: 16525058
references.citation: Prog Neurobiol. 1994 Apr;42(6):719-61
references.pmid: 7938546
references.citation: J Comp Neurol. 2008 Feb 1;506(4):616-26
references.pmid: 18067140
references.citation: Brain Res. 2004 May 8;1007(1-2):167-77
references.pmid: 15064148
references.citation: J Neurosci. 1998 Mar 1;18(5):1650-61
references.pmid: 9464990
references.citation: Hippocampus. 1999;9(4):432-43
references.pmid: 10495024
references.citation: J Comp Neurol. 2009 Apr 20;513(6):597-621
references.pmid: 19235223
references.citation: Neuroscience. 1998 Sep;86(2):635-49
references.pmid: 9881876
references.citation: Trends Neurosci. 2007 May;30(5):203-10
references.pmid: 17400301
references.citation: J Comp Neurol. 1975 Oct 15;163(4):467-505
references.pmid: 1100685
references.citation: Brain Res. 1990 Apr 16;513(2):329-34
references.pmid: 2350704
references.citation: Neuropharmacology. 2009;56 Suppl 1:122-32
references.pmid: 18675281
references.citation: Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3399-404
references.pmid: 16492766
references.citation: Psychopharmacology (Berl). 1995 Nov;122(2):194-7
references.pmid: 8848536
references.citation: J Neurophysiol. 1994 May;71(5):1917-34
references.pmid: 8064357
references.citation: Neuropsychopharmacology. 2002 Mar;26(3):376-86
references.pmid: 11850152
references.citation: J Neuropsychiatry Clin Neurosci. 2008 Fall;20(4):390-408
references.pmid: 19196924
references.citation: J Neurosci. 2005 Jun 29;25(26):6076-83
references.pmid: 15987937
references.citation: Nat Neurosci. 2005 Jun;8(6):805-12
references.pmid: 15908948
references.citation: J Comp Neurol. 1988 Mar 8;269(2):219-34
references.pmid: 3281983
references.citation: Psychopharmacology (Berl). 2000 Aug;151(2-3):184-91
references.pmid: 10972464
references.citation: Brain Res Rev. 2008 Aug;58(2):272-81
references.pmid: 18054796
references.citation: J Neurosci. 2008 Jul 2;28(27):6950-9
references.pmid: 18596169
references.citation: J Neurophysiol. 1998 Jul;80(1):1-27
references.pmid: 9658025
references.citation: J Neurosci. 1998 Oct 1;18(19):8003-15
references.pmid: 9742167
references.citation: Neuroscience. 2008 Apr 9;152(4):1024-31
references.pmid: 18355970
references.citation: Neuroscience. 1998 Dec;87(4):823-30
references.pmid: 9759970
references.citation: Brain Res Rev. 2008 Aug;58(2):322-39
references.pmid: 18055018
references.citation: Neuropsychopharmacology. 2003 Aug;28(8):1412-21
references.pmid: 12799620
references.citation: J Comp Neurol. 2006 Feb 20;494(6):863-75
references.pmid: 16385486
references.citation: J Neurophysiol. 2009 Apr;101(4):1823-35
references.pmid: 19193767
references.citation: Trends Neurosci. 1995 Dec;18(12):527-35
references.pmid: 8638293
references.citation: Neurobiol Learn Mem. 2002 Nov;78(3):625-36
references.pmid: 12559840
references.citation: Annu Rev Neurosci. 2000;23:473-500
references.pmid: 10845072
references.citation: Nat Rev Neurosci. 2004 Nov;5(11):844-52
references.pmid: 15496862
references.citation: J Neurosci. 2003 Jan 1;23(1):7-11
references.pmid: 12514194
references.citation: Regul Pept. 2002 Mar 15;104(1-3):111-7
references.pmid: 11830285
references.citation: Neuroscience. 1999;89(4):1189-208
references.pmid: 10362307
references.citation: Neuroscience. 1987 Oct;23(1):103-20
references.pmid: 3683859
references.citation: J Neurosci. 2005 Dec 14;25(50):11757-67
references.pmid: 16354934
references.citation: Synapse. 2009 Oct;63(10):895-906
references.pmid: 19582784
references.citation: J Neurosci. 2008 Sep 3;28(36):8908-13
references.pmid: 18768684
references.citation: J Neurosci. 2000 May 15;20(10):3864-73
references.pmid: 10804226
references.citation: J Comp Neurol. 1994 Jun 1;344(1):1-19
references.pmid: 7914894
references.citation: J Comp Neurol. 2001 Mar 5;431(2):139-54
references.pmid: 11169996
references.citation: Prog Brain Res. 1996;107:485-511
references.pmid: 8782538
references.citation: Eur J Neurosci. 2006 Jul;24(1):116-34
references.pmid: 16882012
references.citation: Neuropsychopharmacology. 2006 Aug;31(8):1627-36
references.pmid: 16395309
references.citation: Brain Res. 1981 Aug 3;217(2):245-63
references.pmid: 7248789
references.citation: J Comp Neurol. 2002 Dec 2;454(1):15-33
references.pmid: 12410615
references.citation: J Comp Neurol. 1988 Jan 22;267(4):455-71
references.pmid: 3346370
references.citation: Neuroscience. 2007 Mar 30;145(3):1059-76
references.pmid: 17270353
references.citation: Brain Res. 2003 Oct 3;986(1-2):22-9
references.pmid: 12965226
references.citation: Neuron. 2006 May 4;50(3):443-52
references.pmid: 16675398
references.citation: Annu Rev Neurosci. 2000;23:185-215
references.pmid: 10845063
references.citation: Annu Rev Psychol. 1989;40:191-225
references.pmid: 2648975
references.citation: Synapse. 1994 Oct;18(2):104-27
references.pmid: 7839311
references.citation: Brain Res. 1987 Dec 1;435(1-2):71-83
references.pmid: 2892580
references.citation: Brain Res. 1983 Mar 7;262(2):334-8
references.pmid: 6839161
references.citation: J Comp Neurol. 2003 Apr 28;459(2):142-55
references.pmid: 12640666
references.citation: J Comp Neurol. 1996 Jan 08;364(2):254-66
references.pmid: 8788248
references.citation: Neuroscience. 1991;43(2-3):397-417
references.pmid: 1681464
references.citation: Nat Rev Neurosci. 2004 Jun;5(6):483-94
references.pmid: 15152198
references.citation: Hippocampus. 1991 Oct;1(4):415-35
references.pmid: 1727001
references.citation: Synapse. 2002 Jun 15;44(4):227-45
references.pmid: 11984858
references.citation: Neuroscience. 1992 Oct;50(4):751-67
references.pmid: 1448200
references.citation: J Comp Neurol. 1996 Jan 08;364(2):340-62
references.pmid: 8788254
references.citation: Methods Mol Med. 2003;79:75-101
references.pmid: 12506691
references.citation: Ann N Y Acad Sci. 1999 Jun 29;877:49-63
references.pmid: 10415642
references.citation: J Neurosci. 1984 Nov;4(11):2866-76
references.pmid: 6150070
references.citation: Neuroscience. 1991;41(1):1-24
references.pmid: 1676137
references.citation: Proc Natl Acad Sci U S A. 1993 Oct 15;90(20):9576-80
references.pmid: 7692449
references.citation: Neuropsychopharmacology. 2006 Jul;31(7):1356-61
references.pmid: 16319915
references.citation: J Comp Neurol. 1996 Nov 11;375(2):167-86
references.pmid: 8915824
references.citation: J Neurosci. 1995 Sep;15(9):5859-69
references.pmid: 7666171
references.citation: Brain Res. 1996 May 13;720(1-2):211-9
references.pmid: 8782914
references.citation: Neuroscience. 2005;135(1):121-31
references.pmid: 16084659
references.citation: J Neurosci. 2000 Mar 1;20(5):1952-63
references.pmid: 10684896
references.citation: J Comp Neurol. 1999 Jul 26;410(2):197-210
references.pmid: 10414527
references.citation: Neuroscience. 2008 Aug 26;155(3):573-84
references.pmid: 18640246
references.citation: J Physiol. 2008 Apr 15;586(8):2157-70
references.pmid: 18308824
references.citation: Trends Neurosci. 2007 May;30(5):228-35
references.pmid: 17408758
references.citation: Brain Res. 2003 Aug 15;981(1-2):160-7
references.pmid: 12885437
references.citation: Annu Rev Neurosci. 2006;29:565-98
references.pmid: 16776597
references.citation: Brain Res Rev. 2008 Aug;58(2):265-71
references.pmid: 18343506
references.citation: Brain Res Brain Res Rev. 1991 Sep-Dec;16(3):223-44
references.pmid: 1665095
references.citation: J Neurosci. 1984 Nov;4(11):2877-90
references.pmid: 6150071
references.citation: Neuron. 2005 Mar 3;45(5):647-50
references.pmid: 15748840
references.citation: Eur J Neurosci. 2006 Jul;24(1):188-96
references.pmid: 16882016
references.citation: Annu Rev Neurosci. 1992;15:285-320
references.pmid: 1575444
references.citation: J Pharmacol Exp Ther. 2002 Dec;303(3):1216-26
references.pmid: 12438546
references.citation: J Neurophysiol. 1996 Sep;76(3):1413-22
references.pmid: 8890262
references.citation: J Neurosci. 2007 Jun 27;27(26):6923-30
references.pmid: 17596440
references.citation: J Comp Neurol. 1989 Nov 8;289(2):189-201
references.pmid: 2478598
references.citation: Psychopharmacology (Berl). 2000 Aug;151(2-3):166-74
references.pmid: 10972462
references.citation: Nature. 2007 Jun 28;447(7148):1111-5
references.pmid: 17522629
references.citation: Neuron. 2008 Jul 31;59(2):288-97
references.pmid: 18667156
references.citation: J Neurosci. 1999 Jun 1;19(11):4682-94
references.pmid: 10341266
references.citation: J Neurosci. 1996 Jan 15;16(2):714-22
references.pmid: 8551354
references.citation: Neuroscience. 1982 Mar;7(3):615-30
references.pmid: 7070669
references.citation: Behav Neurosci. 1999 Apr;113(2):283-90
references.pmid: 10357453
references.citation: J Neurosci. 2001 Nov 15;21(22):RC181
references.pmid: 11698619
references.citation: Pharmacol Biochem Behav. 1974 Mar-Apr;2(2):249-55
references.pmid: 4857295
references.citation: Trends Neurosci. 2004 Sep;27(9):520-7
references.pmid: 15331233
references.citation: Neuroscience. 1996 Jul;73(1):131-43
references.pmid: 8783237
references.citation: Eur J Neurosci. 1995 Aug 1;7(8):1707-13
references.pmid: 7582125
references.citation: Neuroscience. 2000;96(4):651-6
references.pmid: 10727783
references.citation: Brain Res. 1998 Sep 28;806(2):127-40
references.pmid: 9739125
references.citation: J Neurosci. 2008 Sep 24;28(39):9797-805
references.pmid: 18815264
references.citation: Brain Res. 1985 May 6;333(2):271-84
references.pmid: 2986775
references.citation: Brain Res. 1995 Jun 5;682(1-2):215-21
references.pmid: 7552315
references.citation: Brain Struct Funct. 2008 Sep;213(1-2):129-47
references.pmid: 18239939
references.citation: J Comp Neurol. 1978 Aug 1;180(3):545-80
references.pmid: 659674
references.citation: J Neurosci. 1986 Oct;6(10):3010-23
references.pmid: 3020190
references.citation: J Comp Neurol. 2000 May 1;420(2):211-32
references.pmid: 10753308
references.citation: J Neurosci. 1981 Nov;1(11):1242-59
references.pmid: 6171630
references.citation: Behav Brain Res. 2006 Nov 11;174(2):215-24
references.pmid: 16876265
references.citation: Neuroscience. 2009 Apr 10;159(4):1264-73
references.pmid: 19344638
references.citation: Eur J Neurosci. 1994 Aug 1;6(8):1255-64
references.pmid: 7526940
references.citation: J Neurosci. 1983 Feb;3(2):383-8
references.pmid: 6822869
references.citation: Neuroscience. 2007 May 25;146(3):1259-74
references.pmid: 17391856
references.citation: Adv Pharmacol. 1998;42:686-90
references.pmid: 9327992
references.citation: Brain Res Rev. 2008 Aug;58(2):290-302
references.pmid: 18042492
references.citation: Ann N Y Acad Sci. 2003 Nov;1003:391-4
references.pmid: 14684469
references.citation: J Comp Neurol. 1996 Feb 19;365(4):628-39
references.pmid: 8742307
references.citation: J Neurosci. 1992 Apr;12(4):1335-50
references.pmid: 1348271
references.citation: Ann N Y Acad Sci. 2002 Jun;965:233-46
references.pmid: 12105099
references.citation: J Comp Neurol. 1979 Sep 1;187(1):117-43
references.pmid: 489776
references.citation: Eur J Neurosci. 2009 Jan;29(2):340-58
references.pmid: 19200238
references.citation: PLoS One. 2009;4(4):e5062
references.pmid: 19352511
references.citation: J Neurosci. 2004 Aug 25;24(34):7482-90
references.pmid: 15329395
references.citation: J Neurosci. 2003 May 1;23(9):3930-43
references.pmid: 12736363
references.citation: J Comp Neurol. 2006 Oct 10;498(5):581-92
references.pmid: 16917821
references.citation: Neuroscience. 1991;44(1):15-33
references.pmid: 1722890
references.citation: J Neurosci. 1996 Oct 15;16(20):6579-91
references.pmid: 8815934
references.citation: Neuroscience. 1998 Feb;82(3):767-80
references.pmid: 9483534
references.citation: Neuroscience. 1992 Sep;50(1):149-62
references.pmid: 1383869
references.citation: Biochem Pharmacol. 2008 Jun 1;75(11):2055-69
references.pmid: 18353279
references.citation: Neurosci Biobehav Rev. 2006;30(2):148-72
references.pmid: 16125239
references.citation: Brain Res. 1992 Mar 20;575(2):341-6
references.pmid: 1349255
references.citation: J Comp Neurol. 1993 Nov 8;337(2):267-76
references.pmid: 8277000
references.citation: Mol Interv. 2002 Jun;2(3):146-57
references.pmid: 14993375
references.citation: J Comp Neurol. 1990 Dec 15;302(3):437-46
references.pmid: 1702109
references.citation: Neuroscience. 2000;97(3):479-94
references.pmid: 10828531
references.citation: Life Sci. 1985 May 20;36(20):1983-94
references.pmid: 3990520
references.citation: Nat Neurosci. 2003 Sep;6(9):974-80
references.pmid: 12925855
references.citation: Nature. 2004 Oct 14;431(7010):760-7
references.pmid: 15483596
references.citation: Eur J Neurosci. 1992;4(12):1285-1295
references.pmid: 12106392
references.citation: J Neurosci. 2009 Mar 18;29(11):3613-26
references.pmid: 19295165
references.citation: J Comp Neurol. 1995 May 8;355(3):418-26
references.pmid: 7636023
references.citation: Brain Res Bull. 1982 Jul-Dec;9(1-6):321-53
references.pmid: 6816390
references.citation: J Neurosci. 2002 Jan 1;22(1):294-304
references.pmid: 11756513
references.citation: J Comp Neurol. 1993 Dec 8;338(2):255-78
references.pmid: 8308171
references.citation: Brain Res. 1986 Jun 11;375(2):368-72
references.pmid: 2942222
references.citation: Neuropsychopharmacology. 2008 Oct;33(11):2688-700
references.pmid: 18094667
references.citation: J Comp Neurol. 2009 Apr 20;513(6):566-96
references.pmid: 19235216
references.citation: J Neurosci. 2007 May 23;27(21):5730-43
references.pmid: 17522317
references.citation: Eur J Neurosci. 2007 Jan;25(1):106-18
references.pmid: 17241272
references.citation: J Comp Neurol. 1990 Jul 8;297(2):182-200
references.pmid: 2370319
references.citation: J Comp Neurol. 1979 Mar 1;184(1):43-62
references.pmid: 762282
references.citation: Proc Natl Acad Sci U S A. 1992 Nov 1;89(21):10178-82
references.pmid: 1332033
references.citation: Trends Neurosci. 2007 May;30(5):220-7
references.pmid: 17400299
references.citation: Neuroscience. 2001;104(3):841-51
references.pmid: 11440814
references.citation: Synapse. 2004 Jun 15;52(4):233-44
references.pmid: 15103690
references.citation: Neuroscience. 1994 Aug;61(4):851-65
references.pmid: 7530817
references.citation: Prog Neurobiol. 1980;14(2-3):69-97
references.pmid: 6999537
references.citation: Cereb Cortex. 1998 Jun;8(4):321-45
references.pmid: 9651129
references.citation: J Comp Neurol. 1996 Oct 28;374(4):555-77
references.pmid: 8910735
references.citation: Neuroscience. 2006 Dec 28;143(4):1021-30
references.pmid: 17029800
references.citation: J Anat. 2005 Sep;207(3):271-82
references.pmid: 16185252
references.citation: J Exp Psychol Anim Behav Process. 1983 Jul;9(3):248-65
references.pmid: 6886630
references.citation: J Comp Neurol. 1986 Sep 1;251(1):84-99
references.pmid: 3760260
references.citation: Mol Pharmacol. 2008 Nov;74(5):1463-75
references.pmid: 18703671
references.citation: Neurosci Res. 1995 Feb;21(4):331-42
references.pmid: 7777224
references.citation: J Neurosci. 2004 Aug 25;24(34):7557-65
references.pmid: 15329403
references.citation: J Neurosci Res. 1990 Mar;25(3):263-80
references.pmid: 1969969
references.citation: Neuroscience. 1994 Oct;62(3):707-19
references.pmid: 7870301
references.citation: Neuropharmacology. 2004;47 Suppl 1:33-46
references.pmid: 15464124
references.citation: J Neurosci. 2005 Apr 13;25(15):3857-69
references.pmid: 15829638
references.citation: J Neurosci. 1995 Jul;15(7 Pt 2):5222-37
references.pmid: 7623147
references.citation: Brain Res. 1993 Feb 5;602(2):275-89
references.pmid: 8095430
references.citation: J Neurosci. 2003 Jul 16;23(15):6295-303
references.pmid: 12867514
references.citation: Neuropsychopharmacology. 2006 Dec;31(12):2716-27
references.pmid: 16971900
references.citation: Neuroscience. 1991;41(1):89-125
references.pmid: 2057066
references.citation: J Neurosci. 2000 Mar 15;20(6):2369-82
references.pmid: 10704511
references.citation: J Neurosci. 2005 Jun 29;25(26):6066-75
references.pmid: 15987936
references.citation: J Neurosci. 1986 Jan;6(1):274-80
references.pmid: 2868077
references.citation: Nat Neurosci. 2006 Feb;9(2):251-9
references.pmid: 16415865
references.citation: Exp Brain Res. 1984;54(3):499-512
references.pmid: 6723868
references.citation: Nature. 1976 Apr 22;260(5553):731-2
references.pmid: 944382
references.citation: Brain Res Rev. 2007 Nov;56(1):27-78
references.pmid: 17574681
references.citation: J Neurosci. 2002 Jan 1;22(1):324-37
references.pmid: 11756516
references.citation: Neuroscience. 1999 Mar;89(3):813-25
references.pmid: 10199615
references.citation: J Comp Neurol. 1992 Jun 8;320(2):145-60
references.pmid: 1377716
references.citation: J Comp Neurol. 1979 Sep 1;187(1):19-47
references.pmid: 226566
references.citation: Neuron. 2008 Aug 28;59(4):648-61
references.pmid: 18760700
references.citation: Neuroscience. 1999;92(1):245-54
references.pmid: 10392847
references.citation: J Neurosci. 2008 Oct 1;28(40):10075-80
references.pmid: 18829965
references.citation: Neurosci Lett. 1995 Dec 29;202(1-2):45-8
references.pmid: 8787827
references.citation: J Neurosci. 2005 May 18;25(20):5013-23
references.pmid: 15901782
references.citation: Prog Neurobiol. 1996 Nov;50(4):381-425
references.pmid: 9004351
references.citation: J Neurosci. 1989 Oct;9(10):3463-81
references.pmid: 2795134
references.citation: J Comp Neurol. 2007 Aug 10;503(5):668-84
references.pmid: 17559101
references.citation: J Neurosci. 1996 Mar 1;16(5):1877-93
references.pmid: 8774456
references.citation: Synapse. 2000 Mar 15;35(4):281-91
references.pmid: 10657038
references.citation: J Neurosci. 2008 Oct 29;28(44):11221-30
references.pmid: 18971464
references.citation: Mov Disord. 2008;23 Suppl 3:S534-47
references.pmid: 18781680
references.citation: Brain Res. 1992 May 15;580(1-2):215-24
references.pmid: 1504801
references.citation: Neuroscience. 1989;30(1):33-50
references.pmid: 2473414
references.citation: Science. 2004 Mar 26;303(5666):2040-2
references.pmid: 15044807
references.citation: Nat Neurosci. 2006 May;9(5):636-41
references.pmid: 16582902
references.citation: Depress Anxiety. 2008;25(12):989-92
references.pmid: 19058261
references.citation: Brain Res. 1988 Feb 16;441(1-2):319-30
references.pmid: 2451982
references.citation: J Comp Neurol. 1990 Mar 8;293(2):282-98
references.pmid: 19189717
references.citation: Neuroscience. 1999;89(4):1009-23
references.pmid: 10362291
references.citation: Science. 2005 Mar 4;307(5714):1476-9
references.pmid: 15746431
references.citation: J Comp Neurol. 1990 Sep 8;299(2):187-228
references.pmid: 2172326
references.citation: Trends Neurosci. 2000 Oct;23(10 Suppl):S48-56
references.pmid: 11052220
references.citation: Neuron. 2008 Aug 14;59(3):486-96
references.pmid: 18701073
references.citation: Biol Psychiatry. 2003 Mar 15;53(6):494-501
references.pmid: 12644354
references.citation: J Comp Neurol. 1990 Aug 1;298(1):40-9
references.pmid: 1698828
references.citation: Synapse. 2000 Nov;38(2):114-23
references.pmid: 11018785
references.citation: J Neurosci. 1989 Nov;9(11):3803-15
references.pmid: 2585056
references.citation: Eur J Neurosci. 2000 Oct;12(10):3596-604
references.pmid: 11029630
references.citation: Neuroscience. 1983 Oct;10(2):301-15
references.pmid: 6633863
references.citation: Brain Res. 1992 Oct 30;594(2):253-62
references.pmid: 1280527
references.citation: J Chem Neuroanat. 2006 Dec;32(2-4):101-16
references.pmid: 16914290
references.citation: Neuropsychopharmacology. 1996 Jul;15(1):87-97
references.pmid: 8797195
references.citation: J Comp Neurol. 2002 Apr 29;446(2):151-65
references.pmid: 11932933
references.citation: Ann N Y Acad Sci. 1999 Jun 29;877:140-56
references.pmid: 10415648
references.citation: Nat Neurosci. 2005 Nov;8(11):1481-9
references.pmid: 16251991
references.citation: Neuroscience. 2007 Nov 30;150(1):8-13
references.pmid: 17961928
references.citation: Synapse. 2000 Sep 15;37(4):252-61
references.pmid: 10891862
references.citation: Trends Neurosci. 2007 May;30(5):194-202
references.pmid: 17408759
references.citation: J Neurophysiol. 2009 Apr;101(4):1876-82
references.pmid: 19176610
references.citation: J Neurosci. 1995 May;15(5 Pt 1):3622-39
references.pmid: 7751934
references.citation: J Neurosci. 1997 Mar 15;17(6):2143-67
references.pmid: 9045740
references.citation: Neuroscience. 1997 Jun;78(3):715-29
references.pmid: 9153653
references.citation: Neuron. 2006 Feb 16;49(4):589-601
references.pmid: 16476667
references.citation: Nat Neurosci. 1998 Aug;1(4):304-9
references.pmid: 10195164
references.citation: Neuropharmacology. 2004;47 Suppl 1:61-79
references.pmid: 15464126
references.citation: J Physiol. 2008 Mar 15;586(6):1487-93
references.pmid: 18079157
references.citation: J Physiol. 1992 May;450:455-68
references.pmid: 1331427
references.citation: J Comp Neurol. 1994 Jun 8;344(2):232-41
references.pmid: 7915727
references.citation: J Neurosci. 1998 Dec 1;18(23):9996-10015
references.pmid: 9822755
references.citation: Neuropharmacology. 1999 Feb;38(2):223-31
references.pmid: 10218863
references.citation: Cell Mol Life Sci. 2006 Jul;63(14):1597-613
references.pmid: 16699809
references.citation: J Comp Neurol. 1990 Jun 8;296(2):204-21
references.pmid: 2358532
references.citation: Neuroscience. 1982 Oct;7(10):2321-35
references.pmid: 6817161
references.citation: J Neurosci. 2002 Jun 15;22(12):5173-87
references.pmid: 12077212
references.citation: Neuroscience. 2002;111(2):379-87
references.pmid: 11983323
references.citation: J Exp Psychol Anim Behav Process. 1979 Oct;5(4):368-78
references.pmid: 528893
references.citation: Eur J Neurosci. 2005 May;21(10):2817-24
references.pmid: 15926929
references.citation: J Clin Psychiatry. 2008;69 Suppl 5:9-15
references.pmid: 19265635
references.citation: J Neurosci. 2002 Jul 15;22(14):6247-53
references.pmid: 12122083
references.citation: J Neurophysiol. 1998 Jan;79(1):82-94
references.pmid: 9425179
references.citation: J Pharmacol Exp Ther. 1997 May;281(2):699-706
references.pmid: 9152375
references.citation: Eur J Neurosci. 2003 Feb;17(3):429-35
references.pmid: 12581161
references.citation: Psychopharmacology (Berl). 2003 Jul;168(1-2):44-56
references.pmid: 12652346
references.citation: J Comp Neurol. 1979 Sep 1;187(1):99-115
references.pmid: 489780
references.citation: Brain Res. 1994 Jun 6;647(2):307-22
references.pmid: 7522922
references.citation: J Chem Neuroanat. 1989 Sep-Oct;2(5):285-98
references.pmid: 2572241
references.citation: Neuroscience. 1978;3(4-5):385-401
references.pmid: 683502
references.citation: Neuroscience. 2008 Apr 22;153(1):196-213
references.pmid: 18358616
references.citation: Trends Neurosci. 2008 Nov;31(11):552-8
references.pmid: 18786735
references.citation: Trends Pharmacol Sci. 1992 May;13(5):177-84
references.pmid: 1604710
references.citation: J Neurosci. 2004 Jan 28;24(4):972-81
references.pmid: 14749442
references.citation: Brain Res. 1984 Dec 17;324(1):69-84
references.pmid: 6151418
references.citation: Ann N Y Acad Sci. 2000 Jun;911:369-91
references.pmid: 10911886
references.citation: Brain Res. 1979 Oct 19;175(2):191-217
references.pmid: 314832
references.citation: J Neurosci. 2008 Nov 12;28(46):11825-9
references.pmid: 19005047
references.citation: Eur J Neurosci. 2008 Oct;28(8):1437-48
references.pmid: 18793321
references.citation: Ann N Y Acad Sci. 2008 Oct;1141:1-21
references.pmid: 18991949
references.citation: Behav Brain Res. 1995 Nov;71(1-2):1-10
references.pmid: 8747170
references.citation: Nature. 2001 May 31;411(6837):583-7
references.pmid: 11385572
references.citation: Brain Res. 1990 Sep 17;527(2):266-79
references.pmid: 1701338
references.citation: Brain Res. 1994 Jan 14;634(1):105-12
references.pmid: 8156380
references.citation: Neuropsychopharmacology. 2003 Apr;28(4):629-39
references.pmid: 12655307
references.citation: J Neurosci. 2006 Aug 16;26(33):8549-58
references.pmid: 16914681
references.citation: Neuroscience. 1992 Sep;50(2):371-86
references.pmid: 1279461
references.citation: Behav Brain Res. 2000 Nov 15;116(1):1-22
references.pmid: 11090882
references.citation: J Neurosci. 2008 Jul 30;28(31):7876-82
references.pmid: 18667619
references.citation: J Neurosci. 2001 Jun 1;21(11):4090-103
references.pmid: 11356897
references.citation: J Comp Neurol. 2005 Mar 7;483(2):217-35
references.pmid: 15678476
references.citation: J Comp Neurol. 2005 Sep 26;490(3):270-94
references.pmid: 16082674
references.citation: Eur J Neurosci. 2003 Jan;17(1):28-40
references.pmid: 12534966
references.citation: Neuroscience. 1988 Feb;24(2):379-431
references.pmid: 2452377
references.citation: Synapse. 1997 Feb;25(2):205-14
references.pmid: 9021901
references.citation: J Neurosci. 2004 Feb 4;24(5):1040-9
references.pmid: 14762122
references.citation: Biol Psychiatry. 1999 Jul 1;46(1):40-55
references.pmid: 10394473
references.citation: J Comp Neurol. 2002 Jul 8;448(4):360-72
references.pmid: 12115699
references.citation: Neuroscience. 2005;133(2):463-70
references.pmid: 15878241
references.citation: J Comp Neurol. 1993 Jan 8;327(2):220-32
references.pmid: 8425943
references.citation: J Comp Neurol. 1996 Jan 08;364(2):231-53
references.pmid: 8788247
references.citation: Neuropsychopharmacology. 2004 Dec;29(12):2115-25
references.pmid: 15150533
references.citation: J Comp Neurol. 1992 May 8;319(2):218-45
references.pmid: 1522246
references.citation: Prog Neurobiol. 1998 Apr;54(6):679-720
references.pmid: 9560846
references.citation: J Comp Neurol. 1984 Mar 1;223(3):347-67
references.pmid: 6323552
references.citation: Synapse. 1993 Feb;13(2):135-60
references.pmid: 8446922
references.citation: Neuroscience. 1992 Dec;51(3):533-45
references.pmid: 1488113
references.citation: Annu Rev Neurosci. 2000;23:155-84
references.pmid: 10845062
references.citation: J Comp Neurol. 2005 Mar 14;483(3):351-73
references.pmid: 15682395
references.citation: Neuroscience. 2007 Oct 26;149(2):303-14
references.pmid: 17884297
references.citation: Ann N Y Acad Sci. 2004 Jun;1021:33-50
references.pmid: 15251872
references.citation: Brain Res. 2007 Jun 4;1152:49-56
references.pmid: 17459351
references.citation: Neurosci Biobehav Rev. 2006;30(4):472-96
references.pmid: 16243397
references.citation: Neuroscience. 1993 Nov;57(1):113-42
references.pmid: 8278047
references.citation: Nat Neurosci. 2003 Sep;6(9):968-73
references.pmid: 12897785
references.citation: Neurosci Biobehav Rev. 2000 Jan;24(1):85-105
references.pmid: 10654664
references.citation: Neuron. 2008 Mar 13;57(5):760-73
references.pmid: 18341995
references.citation: Eur J Neurosci. 2007 Aug;26(4):1011-25
references.pmid: 17714194
references.citation: J Comp Neurol. 1999 May 17;407(4):491-511
references.pmid: 10235641
references.citation: Prog Brain Res. 1990;85:119-46
references.pmid: 2094891
references.citation: J Comp Neurol. 1990 Jun 1;296(1):47-64
references.pmid: 1694189
references.citation: Life Sci. 1978 Oct 23;23(16):1715-27
references.pmid: 31529
references.citation: Eur J Pharmacol. 1979 Nov 16;59(3-4):211-8
references.pmid: 527646
references.citation: Cereb Cortex. 2008 Aug;18(8):1961-72
references.pmid: 18065719
references.citation: Annu Rev Neurosci. 2007;30:289-316
references.pmid: 17376009
references.citation: J Neurosci. 2009 Apr 15;29(15):4953-63
references.pmid: 19369564
references.citation: Brain Res. 1994 Aug 22;654(2):324-30
references.pmid: 7987681
references.citation: Brain Res. 1984 Jun 8;302(2):267-75
references.pmid: 6145508
references.citation: Physiol Behav. 2002 Dec;77(4-5):513-7
references.pmid: 12526992
references.citation: Pharmacol Biochem Behav. 1989 Feb;32(2):581-4
references.pmid: 2727020