Isoniazid-triggered pure red cell aplasia in systemic lupus erythematosus complicated with myasthenia gravis.
A 47-year-old woman who had been treated for systemic lupus erythematosus (SLE) with myasthenia gravis (MG) was admitted to our hospital with acute onset of severe anemia after administration of isoniazid. Pure red cell aplasia (PRCA) was confirmed by elevated serum iron levels, reticulocytopenia and bone marrow aspiration showing a remarkable reduction of erythroblasts. Finally, cyclosporine A successfully improved PRCA. Although both SLE and MG have the potential complication of PRCA, we report here a case of isoniazid-triggered PRCA.
Nakamura
Hideki
H
Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki city, Nagasaki, 852-8501, Japan. nhideki@nagasaki-u.ac.jp
Okada
Akitomo
A
Kawakami
Atsushi
A
Yamasaki
Satoshi
S
Ida
Hiroaki
H
Motomura
Masakatsu
M
Imanishi
Daisuke
D
Eguchi
Katsumi
K
D000995:Antitubercular Agents / Q000009:adverse effects*; D016572:Cyclosporine / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004900:Erythroblasts; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007501:Iron / Q000097:blood; D007538:Isoniazid / Q000009:adverse effects*; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000188:drug therapy*; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000150:complications / Q000188:drug therapy*; D012010:Red-Cell Aplasia, Pure / Q000097:blood / Q000139:chemically induced* / Q000188:drug therapy; D017701:Reticulocyte Count; D012156:Reticulocytes / Q000473:pathology; D016896:Treatment Outcome
D000995:Antitubercular Agents; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D007501:Iron; D007538:Isoniazid
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