Clinical factors related to suspected second primary lung cancer development in patients with head and neck cancer.
OBJECTIVE
The rate of second primary lung cancer development for patients with head and neck cancer (HNC) has been noted. The aim of our study was to evaluate the incidence and clinical features of suspected second primary lung cancer that developed in patients with primary HNC.


METHODS
We conducted a retrospective study of 469 patients who were newly diagnosed with HNC at the Korea University Medical Center between January 2000 and December 2006.


RESULTS
A total of 469 patients were included (389 men and 80 women). Eighteen patients (3.8%) had suspected second primary lung cancers. Statistically significant clinical variables for lung cancer development included the origin site for the primary HNC (oro-hypopharynx and larynx) (p=0.048), abnormal chest x-ray findings (p=0.027) and the histological HNC type (squamous cell carcinoma) (p=0.032). When the second primary lung cancers were combined with HNCs, the adjusted overall survival of patients with a second primary lung cancer was 16 months (p<0.001).


CONCLUSIONS
Considering the relative risk factors for a second primary lung cancer developing in patients with HNC, advanced diagnostic tools, such as chest CT or PET CT scan, should be applied for the early detection of a second primary lung cancer.
Kim
Eui Bae
EB
Division of Oncology/Hematology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
Park
Yong
Y
Park
Seh Jong
SJ
Kim
Dae Sik
DS
Kim
Jee Won
JW
Seo
Hee Yun
HY
Sung
Hwa Jung
HJ
Choi
In Keun
IK
Park
Kyong Hwa
KH
Oh
Sang Cheul
SC
Choi
Chul Won
CW
Kim
Byung Soo
BS
Kim
Yeul Hong
YH
Kim
Jun Suk
JS
Shin
Sang Won
SW
Kim
Chul Yong
CY
Jung
Kwang-Yoon
KY
J Comput Assist Tomogr. 2008 Mar-Apr;32(2):222-7
18379306
Acta Otolaryngol. 2002 Oct;122(7):765-78
12484655
Laryngoscope. 2002 Jan;112(1):120-3
11802049
Am J Surg. 1987 Oct;154(4):434-8
3661848
Head Neck Surg. 1980 Nov-Dec;3(2):90-6
7440181
Otolaryngol Head Neck Surg. 1990 Jul;103(1):14-24
2117726
Laryngoscope. 1998 Feb;108(2):250-6
9473077
Arch Otolaryngol. 1984 Sep;110(9):564-5
6477272
Cancer. 1995 Mar 15;75(6):1343-53
7882285
Jpn J Clin Oncol. 1997 Apr;27(2):63-6
9152791
Cancer Causes Control. 2007 Apr;18(3):269-78
17237987
Ann Oncol. 2005;16 Suppl 6:vi7-vi12
15987995
J Am Dent Assoc. 1983 Jan;106(1):33-5
6574163
J Laryngol Otol. 2001 Dec;115(12):988-91
11779329
Cancer. 1953 Sep;6(5):963-8
13094644
Laryngoscope. 2002 Nov;112(11):2002-8
12439170
AJR Am J Roentgenol. 2008 Mar;190(3):755-61
18287449
Ann Otol Rhinol Laryngol. 1983 Jul-Aug;92(4 Pt 1):373-6
6881843
Head Neck. 2005 Nov;27(11):990-4
16136584
Ear Nose Throat J. 2006 Feb;85(2):74
16579185
Cancer. 1992 Aug 15;70(4):815-20
1643613