[A case of unresectable advanced pancreatic cancer treated by gemcitabine-based chemotherapy following cancer pain alleviation by low-dose matrix-type transdermal fentanyl].
Cancer pain often makes patient's performance status worsen and is one of the difficulties in anti-cancer therapy. We report a case of unresectable advanced pancreatic cancer with cancer pain, which was treated by matrix-type transdermal fentanyl following slow-releasing oxycodone, which caused severe constipation. Rotation to matrix-type transdermal fentanyl (Durotep MT 2.1 mg) releaved severe constipation as well as cancer pain. The patient could take gemcitabine-based chemotherapy. Low-dose matrix-type transdermal fentanyl (Durotep MT 2.1 mg) is useful for opioid rotation from low-dose morphine or oxycodone with uncontrolled side effects, and it contributes to continuation of anti-cancer therapy.
Matsuyama
Kazuyo
K
Cancer Support Team, Osaka National Hospital, National Hospital Organization.
Satomi
Eriko
E
Ueno
Hiroyuki
H
Inoue
Atsuyuki
A
Oike
Mari
M
Todaka
Kinuyo
K
Yoshida
Tetsuhiko
T
Sekiyama
Ryuji
R
Hirotsune
Hideto
H
Sueta
Kiyomichi
K
Miyamoto
Atsushi
A
Nakamori
Shoji
S
Tsujinaka
Toshimasa
T
Komori
Katsuya
K
D000279:Administration, Cutaneous; D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D003841:Deoxycytidine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage*; D006801:Humans; D010148:Intractable Pain / Q000188:drug therapy*; D010190:Pancreatic Neoplasms / Q000188:drug therapy*; D000093542:Gemcitabine
D000964:Antimetabolites, Antineoplastic; D003841:Deoxycytidine; D005283:Fentanyl; D000093542:Gemcitabine