title: New nitrogen-containing sesquiterpenoids from the Taiwanese soft coral Cespitularia taeniata May.
abstract: Chemical investigation of the EtOH extract of the soft coral Cespitularia taeniata May collected in Taiwan has resulted in the isolation of two new sesquiterpene lactams, taenialactams A and B (1 and 2, resp.), and a new sesquiterpene lactone, taenialactone A (3), together with 8beta-methoxyatractylenolide (4) and atractylenolactam (5). The structures of these compounds were determined on the basis of spectroscopic analyses. The in vitro cytotoxic activities of the isolated metabolites were tested against KB, Daoy, and WiDr cell lines. A biogenetic pathway for these novel compounds was proposed.
authors.affiliation: School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC.
authors.forename: Yuan-Bin
authors.initials: YB
authors.lastname: Cheng
authors.forename: Ching-Yeu
authors.initials: CY
authors.lastname: Chen
authors.forename: Yao-Haur
authors.initials: YH
authors.lastname: Kuo
authors.forename: Ya-Ching
authors.initials: YC
authors.lastname: Shen
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D018922:HL-60 Cells; D006801:Humans; D007624:KB Cells; D019906:Nuclear Magnetic Resonance, Biomolecular; D012717:Sesquiterpenes / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D012717:Sesquiterpenes