Therapeutic vaccines for malignant brain tumors.
Malignant gliomas are the most common and aggressive form of brain tumors. Current therapy consists of surgical resection, followed by radiation therapy and concomitant chemotherapy. Despite these treatments, the prognosis for patients is poor. As such, investigative therapies including tumor vaccines have targeted this devastating condition. Recent clinical trials involving immunotherapy, specifically dendritic cell (DC) based vaccines, have shown promising results. Overall, these vaccines are well tolerated with few documented side effects. In many patients receiving vaccines, tumor progression was delayed and the median overall survival of these patients was prolonged. Despite these encouraging results, several factors have limited the efficacy of DC vaccines. Here we discuss the potential of DC vaccines as adjuvant therapy and current obstacles of generating highly pure and potent DC vaccines in the context of malignant glioma. Taken together, the results from earlier clinical studies justify additional clinical trials aimed at improving the efficacy of DC vaccines.
Gustafson
Michael P
MP
Division of Transfusion Medicine;
Knutson
Keith L
KL
Dietz
Allan B
AB
J Leukoc Biol. 1996 Feb;59(2):208-18
8603993
J Neurooncol. 2005 May;73(1):29-36
15933813
J Transl Med. 2007 Dec 19;5:68
18093336
Oncogene. 2005 Aug 4;24(33):5226-34
15897911
Eur J Immunol. 1997 Dec;27(12):3135-42
9464798
Biochem Biophys Res Commun. 2000 Sep 7;275(3):731-8
10973791
Gene Ther Mol Biol. 2006;10(A):133-146
16810329
Cancer Res. 2006 Nov 1;66(21):10247-52
17079441
Clin Cancer Res. 2004 Aug 15;10(16):5316-26
15328167
Cancer Res. 2004 Jul 15;64(14):4973-9
15256471
Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):351-8
11773639
Transfus Med. 2004 Apr;14(2):81-96
15113373
J Neurooncol. 2003 Aug-Sep;64(1-2):71-6
12952288
Nat Med. 2004 May;10(5):475-80
15122249
Mayo Clin Proc. 2007 Oct;82(10):1271-86
17908533
J Immunother. 2007 Jan;30(1):1-15
17198079
Nat Rev Immunol. 2007 Oct;7(10):790-802
17853902
Cancer Cell. 2006 May;9(5):391-403
16697959
Cancer Res. 2006 Mar 15;66(6):3294-302
16540683
Virchows Arch. 2001 Aug;439(2):176-84
11561758
Cancer Immunol Immunother. 2006 Mar;55(3):237-45
16047143
Trends Immunol. 2006 Jan;27(1):49-55
16310411
Blood. 2002 Jul 1;100(1):174-7
12070024
Blood. 2004 Oct 15;104(8):2235-46
15231572
Methods. 2003 Jul;30(3):256-68
12798140
Clin Cancer Res. 2003 Nov 1;9(14):5091-100
14613986
Neuro Oncol. 2006 Jul;8(3):234-43
16723631
J Exp Med. 2003 Jul 21;198(2):267-79
12874260
Clin Cancer Res. 2005 Aug 1;11(15):5515-25
16061868
Eur J Immunol. 2007 Mar;37(3):686-95
17301951
Cancer Immunol Immunother. 2005 Aug;54(8):721-8
16010587
Br J Cancer. 2003 Oct 6;89(7):1172-9
14520441
J Immunother. 2004 Nov-Dec;27(6):452-9
15534489
J Neurooncol. 2003 Aug-Sep;64(1-2):161-76
12952297
Clin Cancer Res. 2005 Jul 15;11(14):5292-9
16033848
Neuro Oncol. 2004 Jul;6(3):218-26
15279714
Proc Natl Acad Sci U S A. 1996 Mar 19;93(6):2588-92
8637918
Cancer Immunol Immunother. 2008 Mar;57(3):285-8
17721782
N Engl J Med. 2005 Oct 20;353(16):1711-23
16236742
Biotechnol Prog. 2005 Jul-Aug;21(4):1289-96
16080713
J Clin Oncol. 2004 Nov 1;22(21):4272-81
15452186
J Exp Med. 2004 Mar 15;199(6):815-24
15024047
Cell Tissue Res. 2006 Aug;325(2):263-76
16557385
Clin Exp Immunol. 1999 Mar;115(3):577-83
10193437
J Immunol. 1996 Nov 1;157(9):3850-9
8892615
Cancer Immunol Immunother. 2002 Jun;51(4):190-9
12012106
Br J Cancer. 2004 Nov 1;91(9):1656-62
15477864
Clin Cancer Res. 2005 Jun 1;11(11):4160-7
15930352
J Immunol. 2007 Dec 15;179(12):8216-24
18056365
Neurosurgery. 2006 Oct;59(4):902-9; discussion 909-10
17038955
Cancer Res. 2007 Nov 1;67(21):10528-37
17974997
J Neurosurg Sci. 1990 Apr-Jun;34(2):145-8
2092095
J Immunol. 1995 Apr 15;154(8):3821-35
7706722
Immunity. 2003 May;18(5):605-17
12753738
J Exp Med. 1994 Apr 1;179(4):1109-18
8145033
J Neuroimmunol. 1998 Apr 15;84(2):164-71
9628459
Brain. 2008 Mar;131(Pt 3):785-99
18156156
J Immunother. 2004 May-Jun;27(3):220-6
15076139
Front Biosci. 2006 May 01;11:1932-44
16368569
Cancer Res. 2001 Feb 1;61(3):842-7
11221866
Clin Cancer Res. 2005 Aug 15;11(16):5900-11
16115932
Clin Cancer Res. 2006 Apr 1;12(7 Pt 2):2346s-2352s
16609057
Oncogene. 2008 Mar 27;27(14):2091-6
17934519
J Clin Neurosci. 2006 Aug;13(7):747-51
16908158
Cancer Immunol Immunother. 2002 Oct;51(8):424-30
12202903
Blood. 2006 Feb 15;107(4):1528-36
16239433
J Neuropathol Exp Neurol. 2004 Mar;63(3):223-32
15055446
Neuro Oncol. 2004 Jul;6(3):236-46
15279716
N Engl J Med. 2005 Mar 10;352(10):987-96
15758009
J Neuroimmunol. 1998 Apr 15;84(2):238-49
9628469