Hemorrhagic regression of melanoma metastases during therapeutic vaccination: a report of three cases.
Melanoma metastases are characterized by pronounced neo-angiogenesis and spontaneous bleeding frequently occurring within central nervous system metastases. Clinically apparent spontaneous hemorrhage within subcutaneous melanoma metastases, however, is a rare event that coincides with progression of such metastases. We report, to our knowledge the first observation, on regression of subcutaneous metastases with hemorrhage of the overlying skin in three patients with stage IV melanoma who participated in clinical trials on therapeutic vaccination. In two patients, loss of arterial flow on Doppler ultrasound imaging was documented in the metastasis at the time of hematoma formation. One patient suffered from an intracranial hemorrhage in a subcentimetric brain metastasis coincident with the hemorrhagic regression of some of his skin metastases.
Pierret
Lauranne
L
Medical Oncology, Oncology Center, UZ Brussel, Laarbeeklaan 101, Brussel 1090, Belgium.
Baren
Nicolas Van
NV
Bonehill
Aude
A
Corthals
Jurgen
J
Van Nuffel
An M T
AM
Heirman
Carlo
C
Roelandt
Truus
T
De Coninck
Arlette
A
Riet
Ivan Van
IV
Degreef
Ellen
E
Goossens
Annieta
A
Verfaillie
Guy
G
Roseeuw
Diane
D
Thielemans
Kris
K
Neyns
Bart
B
D000328:Adult; D019496:Cancer Vaccines / Q000627:therapeutic use*; D016543:Central Nervous System Neoplasms / Q000098:blood supply / Q000473:pathology / Q000556:secondary*; D018450:Disease Progression; D005260:Female; D006470:Hemorrhage / Q000150:complications*; D006801:Humans; D020300:Intracranial Hemorrhages / Q000209:etiology; D008297:Male; D008545:Melanoma / Q000098:blood supply / Q000556:secondary* / Q000628:therapy; D008875:Middle Aged; D009389:Neovascularization, Pathologic; D012878:Skin Neoplasms / Q000098:blood supply / Q000473:pathology / Q000628:therapy; D014611:Vaccination
D019496:Cancer Vaccines