Intima media thickness and endothelial function in chronic hemodialysis patients.
The purpose of our study was to evaluate the intima-media thickness (IMT) of the carotid and brachial arteries, flow-mediated dilatation (FMD), and nitroglycerin-mediated dilatation (NMD) in diabetic and non-diabetic hemodialysis patients. We also examined the effects of traditional and other risk factors on carotid and brachial IMT, FMD and NMD in all hemodialysis patients. Fifty-eight adult hemodialysis patients, 14 of whom had diabetes, were studied. They had been on hemodialysis for 1-340 months. Using B-mode ultrasonography, we measured the carotid and brachial IMT, FMD and NMD, and correlated the values with cardiovascular risk factors. FMD and NMD were significantly lower in diabetic patients (FMD 4.01 +/- 0.99 vs. 6.69 +/- 2.37 mm; NMD 9.1 +/- 1.95 vs. 11.23 +/- 2.86 mm), while no such differences were found between the two groups with respect to carotid or brachial IMT. In all patients with respect to age a positive correlation was found with carotid and brachial IMT, and a negative one with FMD and NMD. With respect to hypertension as well as diabetes, a negative correlation was found with FMD and NMD. Age is the most important factor that significantly affected all studied markers of atherosclerosis in hemodialysis patients. The endothelial and smooth vascular functions are significantly impaired in diabetic and hypertensive hemodialysis patients, and hypertension is shown to be an independent risk factor for smooth vascular dysfunction in hemodialysis patients. According to our results, intensive antihypertensive treatment is recommended in hypertensive chronic hemodialysis patients.
Rus
Rina
R
Department of Pediatric Nephrology, Univerity Medical Center Ljubljana, SI-1000 Ljubljana, Slovenia. rina.rus@guest.arnes.si
Buturović-Ponikvar
Jadranka
J
D000328:Adult; D000367:Age Factors; D001916:Brachial Artery / Q000000981:diagnostic imaging / Q000473:pathology; D002318:Cardiovascular Diseases / Q000209:etiology; D002339:Carotid Arteries / Q000473:pathology; D003920:Diabetes Mellitus / Q000503:physiopathology*; D004730:Endothelium, Vascular / Q000473:pathology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D005996:Nitroglycerin / Q000494:pharmacology; D006435:Renal Dialysis; D012307:Risk Factors; D017539:Tunica Intima / Q000000981:diagnostic imaging / Q000473:pathology; D017540:Tunica Media / Q000000981:diagnostic imaging / Q000473:pathology; D014463:Ultrasonography; D014664:Vasodilation
D005996:Nitroglycerin