title: Acute leukemia of ambiguous lineage, biphenotype, without CD34, TdT or TCR-rearrangement.
abstract: Biphenotypic acute leukemia (BAL) is a rare entity that comprises 0.5-3% of all acute leukemias and probably arises from multipotent progenitor cells. The optimal approach for BAL therapy is unknown. Thus, it is important to elucidate the origin of the neoplastic cells for determination of the appropriate therapy. We report the case of a 41-year-old man with BAL having myeloid and T-lymphoid lineage phenotypes. Strangely, neither CD34 nor TdT expression nor rearrangement of TCR-alpha/beta, delta/gamma genes were shown. This pattern is rarely encountered and suggests that the blast cells were possibly considered immature with aspects of differentiation indicating myeloid lineage, rather than T-lymphoid lineage.
authors.affiliation: Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Kagawa University. t111nishiuchi@yahoo.co.jp
authors.forename: Takamasa
authors.initials: T
authors.lastname: Nishiuchi
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Ohnishi
authors.forename: Rie
authors.initials: R
authors.lastname: Kamada
authors.forename: Fumi
authors.initials: F
authors.lastname: Kikuchi
authors.forename: Takamichi
authors.initials: T
authors.lastname: Shintani
authors.forename: Fusako
authors.initials: F
authors.lastname: Waki
authors.forename: Akira
authors.initials: A
authors.lastname: Kitanaka
authors.forename: Yoshitsugu
authors.initials: Y
authors.lastname: Kubota
authors.forename: Terukazu
authors.initials: T
authors.lastname: Tanaka
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Ishida
mesh_terms: D000328:Adult; D018952:Antigens, CD34 / Q000235:genetics*; D019070:Cell Lineage / Q000235:genetics*; D004253:DNA Nucleotidylexotransferase / Q000235:genetics*; D015321:Gene Rearrangement / Q000235:genetics*; D006801:Humans; D015456:Leukemia, Biphenotypic, Acute / Q000175:diagnosis / Q000235:genetics*; D008297:Male; D011948:Receptors, Antigen, T-Cell / Q000235:genetics; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics*; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000235:genetics*
chemical_list: D018952:Antigens, CD34; D011948:Receptors, Antigen, T-Cell; D016693:Receptors, Antigen, T-Cell, alpha-beta; D016692:Receptors, Antigen, T-Cell, gamma-delta; D004253:DNA Nucleotidylexotransferase