Gender Differences in Cognitive Control: an Extended Investigation of the Stop Signal Task.
Men and women show important differences in clinical conditions in which deficits in cognitive control are implicated. We used functional magnetic resonance imaging to examine gender differences in the neural processes of cognitive control during a stop-signal task. We observed greater activation in men, compared to women, in a wide array of cortical and sub-cortical areas, during stop success (SS) as compared to stop error (SE). Conversely, women showed greater regional brain activation during SE > SS, compared to men. Furthermore, compared to women, men engaged the right inferior parietal lobule to a greater extent during post-SE go compared to post-go go trials. Women engaged greater posterior cingulate cortical activation than men during post-SS slowing in go trial reaction time (RT) but did not differ during post-SE slowing in go trial RT. These findings extended our previous results of gender differences in regional brain activation during response inhibition. The results may have clinical implications by, for instance, helping initiate studies to understand why women are more vulnerable to depression while men are more vulnerable to impulse control disorders.
Li
Chiang-Shan Ray
CS
Zhang
Sheng
S
Duann
Jeng-Ren
JR
Yan
Peisi
P
Sinha
Rajita
R
Mazure
Carolyn M
CM
Drug Alcohol Depend. 2006 Dec 1;85(3):205-12
16725282
J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2005 Mar;191(3):201-11
15759141
Neuroimage. 2008 Jul 15;41(4):1352-63
18485743
Exp Brain Res. 2005 Nov;167(2):305-9
16160823
Exp Clin Psychopharmacol. 2003 Aug;11(3):210-7
12940500
Neuroimage. 2006 Apr 1;30(2):529-38
16260156
J Neurosci. 2006 Aug 30;26(35):9015-21
16943559
J Int Neuropsychol Soc. 2005 Sep;11(5):631-44
16212691
Neuroreport. 2005 Feb 8;16(2):85-7
15671851
J Cogn Neurosci. 1997 Fall;9(5):648-63
23965122
Psychol Rev. 2014 Jan;121(1):66-95
24490789
Curr Opin Neurobiol. 2004 Apr;14(2):233-8
15082330
Dev Psychopathol. 2006 Fall;18(4):1055-103
17064429
Alcohol Clin Exp Res. 1991 Aug;15(4):661-7
1928641
Biol Psychiatry. 2007 Sep 15;62(6):593-9
17544379
J Cogn Neurosci. 2007 Dec;19(12):1923-31
17892388
Neuroimage. 2005 Jan 15;24(2):586-90
15627602
Neuropsychologia. 2007 Mar 2;45(4):741-7
16999980
Neuroimage. 2006 Oct 1;32(4):1918-29
16806976
Neuroimage. 2002 Sep;17(1):95-109
12482070
Neuroimage. 2008 Feb 1;39(3):1383-95
18032069
Neurosci Biobehav Rev. 2008;32(2):265-78
17919725
Psychophysiology. 2003 Nov;40(6):895-903
14986842
J Neurophysiol. 1995 Sep;74(3):1083-94
7500134
Nat Rev Neurosci. 2002 Mar;3(3):201-15
11994752
Cereb Cortex. 2004 Sep;14(9):986-94
15115734
J Abnorm Psychol. 1990 Feb;99(1):86-91
2307771
Neuropsychopharmacology. 2001 May;24(5):467-77
11282247
Nat Neurosci. 2006 Jul;9(7):971-8
16767087
J Am Coll Health. 1987 Sep;36(2):123-9
3312362
Clin Neurophysiol. 2007 Mar;118(3):581-96
17188565
Behav Sci Law. 2004;22(3):415-25
15211560
Q J Exp Psychol. 1968 Aug;20(3):297-300
5683769
Genet Soc Gen Psychol Monogr. 1999 Nov;125(4):333-412
10570820
Biol Psychiatry. 2006 Jan 1;59(1):40-7
16139815
Arch Gen Psychiatry. 2008 Feb;65(2):179-88
18250256
J Acoust Soc Am. 1971 Feb;49(2):Suppl 2:467+
5541744
Neuropsychologia. 2008 Oct;46(12):2904-13
18577391
Nat Rev Neurosci. 2008 Feb;9(2):148-58
18209732
Neuroimage. 2006 Nov 15;33(3):999-1010
17005420
J Cogn Neurosci. 2003 Aug 15;15(6):810-20
14511534
Neuroimage. 2007 Jul 1;36(3):1015-25
17481919
J Clin Psychiatry. 2002 Jul;63(7):616-27
12143921
Neuroimage. 2005 Jul 1;26(3):860-9
15955496
Neurosci Biobehav Rev. 2008;32(3):581-97
18164058
Soc Psychiatry Psychiatr Epidemiol. 2008 Dec;43(12):983-98
18575787
Nurs Clin North Am. 2004 Mar;39(1):69-81
15062728
Biol Psychiatry. 2000 Aug 15;48(4):259-64
10960156
Nebr Symp Motiv. 2004;50:19-55
15160637
Hum Brain Mapp. 2009 Jan;30(1):24-37
17979124
Horm Behav. 2001 Nov;40(3):396-402
11673912
Neuropsychology. 2005 Jul;19(4):509-19
16060826
Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):676-82
11209064
J Cogn Neurosci. 2008 Jun;20(6):1021-9
18211230
Int J Psychophysiol. 2006 Nov;62(2):203-11
16828187
Emotion. 2008 Feb;8(1):58-67
18266516
J Health Soc Behav. 1992 Dec;33(4):348-62
1464719
Hum Brain Mapp. 2007 Apr;28(4):263-74
17133387
Cereb Cortex. 2007 Aug;17(8):1906-17
17060367
Biol Psychiatry. 2008 Feb 15;63(4):377-84
17719567
Neuroimage. 2006 Oct 1;32(4):1760-70
16863694
Neuroreport. 2000 Aug 3;11(11):2581-5
10943726
Psychol Rev. 2008 Apr;115(2):291-313
18426291
Biol Psychiatry. 2007 Oct 15;62(8):847-55
17544382
J Gen Intern Med. 2002 May;17(5):387-97
12047738
Hum Brain Mapp. 2007 Dec;28(12):1347-58
17274022
Neuroimage. 2003 Nov;20(3):1649-60
14642475
J Child Psychol Psychiatry. 2007 May;48(5):446-54
17501725
Neuropsychopharmacology. 2003 Apr;28(4):613-9
12655305
Behav Cogn Neurosci Rev. 2004 Sep;3(3):159-72
15653813
Hum Brain Mapp. 1999;7(4):254-66
10408769
J Affect Disord. 2008 Nov;111(1):13-20
18603301
Psychiatr Clin North Am. 1999 Jun;22(2):241-52
10385931
Trends Mol Med. 2006 Dec;12(12):559-66
17070107
J Abnorm Child Psychol. 2004 Jun;32(3):285-93
15228177
Hum Brain Mapp. 2006 Aug;27(8):694-705
16404736
Cortex. 2005 Jun;41(3):377-88
15871602
Neuroradiology. 2006 Jan;48(1):14-20
16328492
Am J Psychiatry. 2002 Oct;159(10):1642-52
12359667
Neuroscience. 2008 Sep 9;155(4):1142-51
18674592
Am J Psychiatry. 2001 Nov;158(11):1783-93
11691682
Neuroimage. 2003 Jul;19(3):513-31
12880784
Nat Rev Neurosci. 2008 Apr;9(4):304-13
18319727
J Neurosci. 2005 Oct 26;25(43):9919-31
16251440
Arch Womens Ment Health. 2003 Feb;6(1):5-8
12715259
J Exp Psychol. 1966 Feb;71(2):264-72
5948188
Neuroimage. 2005 Jan 15;24(2):495-503
15627591
Hum Brain Mapp. 2007 Nov;28(11):1163-77
17538951
Cortex. 2007 Jan;43(1):146-58
17334214
Prog Brain Res. 2005;150:205-17
16186025
Psychopharmacology (Berl). 1999 Oct;146(4):373-90
10550488
Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):253-8
12506194
Neuroimage. 2007 Jun;36(2):388-95
17451973
Psychopharmacology (Berl). 2005 Nov;182(4):570-8
16163530
J Neurosci. 2006 Jan 4;26(1):186-92
16399686
Neuropsychologia. 2000;38(4):451-61
10683395
Neuropsychopharmacology. 2008 Jul;33(8):1798-806
17895916