Ciliated adenocarcinoma of the ovary with evidence of serous differentiation: report of a case.
A patient with bilateral ovarian adenocarcinomas composed predominantly of ciliated cells incidentally found at autopsy is reported. Although obviously malignant, a majority of the cells expressed well-differentiated cilia with terminal bar formation. In one of the masses, the neoplastic cells seemed to arise from a serous adenofibroma. The tumor was confined to the ovaries without evidence of metastatic spread. Although morphologically resembling an endometrioid-type neoplasm, immunohistochemical and molecular studies were more consistent with a serous phenotype, especially in light of its apparent origination from a serous adenofibroma. We agree with previous observations suggesting that although the neoplasm seems morphologically worrisome, it may actually portend a more benign clinical course.
Sciallis
Andrew Peter
AP
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA.
Aubry
Marie-Christine
MC
Bell
Debra A
DA
D000230:Adenocarcinoma / Q000150:complications / Q000473:pathology*; D000232:Adenofibroma / Q000473:pathology; D000368:Aged; D017545:Aortic Aneurysm, Thoracic / Q000150:complications / Q000473:pathology; D001019:Aortic Rupture / Q000150:complications / Q000473:pathology; D001344:Autopsy; D002454:Cell Differentiation; D002923:Cilia / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D033162:Incidental Findings; D010051:Ovarian Neoplasms / Q000150:complications / Q000473:pathology*