Rapid and efficient synthesis of fused heterocyclic pyrimidines under ultrasonic irradiation.
Some fused heterocyclic pyrimidines have been synthesized in high yields using ultrasound irradiation in a one-pot, three-component and efficient process by condensation reaction of barbituric acids, aldehydes and a series of enamines in water. Prominent among the advantages of this new method are operational simplicity, good yields in short reaction times and easy work-up procedures employed.
Mosslemin
Mohammad Hossein
MH
Department of Chemistry, Islamic Azad University, Yazd Branch, P.O. Box 89195-155, Yazd, Iran. mosleminemh@yahoo.com
Nateghi
Mohammad Reza
MR
D000447:Aldehydes / Q000737:chemistry / Q000528:radiation effects; D000588:Amines / Q000737:chemistry / Q000528:radiation effects; D001463:Barbiturates / Q000737:chemistry / Q000528:radiation effects; D006571:Heterocyclic Compounds / Q000737:chemistry* / Q000528:radiation effects*; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000528:radiation effects*; D011829:Radiation Dosage; D013010:Sonication / Q000379:methods*; D014867:Water / Q000737:chemistry
D000447:Aldehydes; D000588:Amines; D001463:Barbiturates; D006571:Heterocyclic Compounds; D011743:Pyrimidines; D014867:Water; C032232:barbituric acid