Association between beta2-glycoprotein I plasma levels and the risk of myocardial infarction in older men.
von Willebrand factor (VWF) serves as adhesive surface for platelets to adhere to the vessel wall. We have recently found that beta2-glycoprotein I is able to inhibit platelet binding to VWF, indicating a role in the pathophysiology of arterial thrombosis. In the present study, we investigated whether differences in beta2-glycoprotein I plasma levels influence the risk of myocardial infarction. We have measured beta2-glycoprotein I and VWF antigen levels in 539 men with a first myocardial infarction and in 611 control subjects. Although we did not find a profound effect of beta2-glycoprotein I plasma levels on myocardial infarction in the overall population, we found a dose-dependent protective effect of increasing beta2-glycoprotein I plasma levels on myocardial infarction in men 60 years and older. In this age group, we found an odds ratio of 0.41 (95% confidence interval, 0.22-0.74) for high beta2-glycoprotein I levels compared with low levels. High plasma levels of beta2-glycoprotein I remained protective for myocardial infarction despite high levels of VWF. To conclude, high circulating levels of beta2-glycoprotein I appeared to be associated with a reduced risk of myocardial infarction in elderly men. In vivo experiments are needed to investigate the exact contribution of beta2-glycoprotein I on the pathophysiology of myocardial infarction.
de Laat
Bas
B
Department of Plasma Proteins, Sanquin Research, Amsterdam, The Netherlands. b.delaat@sanquin.nl
de Groot
Philip G
PG
Derksen
Ronald H W M
RH
Urbanus
Rolf T
RT
Mertens
Koen
K
Rosendaal
Frits R
FR
Doggen
Carine J M
CJ
D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000453:epidemiology / Q000235:genetics; D009426:Netherlands / Q000453:epidemiology; D011379:Prognosis; D012307:Risk Factors; D055815:Young Adult; D053482:beta 2-Glycoprotein I / Q000097:blood*; D014841:von Willebrand Factor / Q000378:metabolism
D053482:beta 2-Glycoprotein I; D014841:von Willebrand Factor