The temporal course of mucoperiosteal flap revascularization at guided bone regeneration-treated implant sites: a pilot study.
OBJECTIVE
To investigate post-operative capillary density regeneration in healing mucoperiosteal flaps at guided bone regeneration-treated implant sites.


METHODS
A non-invasive post-operative investigation was performed in 10 patients using orthogonal polarization spectral (OPS) imaging for assessment of capillary density during the course of mucoperiosteal flap wound healing for 6 weeks in patients receiving dental implants.


RESULTS
The greatest increase in capillary regeneration occurred in the early wound-healing phase, during weeks 1 and 2, and recovery to baseline was achieved between weeks 4 and 5. A comparison of adjacent OPS measurements indicated that differences between the time point immediately following administration of local anaesthesia and directly post-operatively ( p=0.002), between a directly post-operative time point and after 1 week (p=0.009), and between post-operative weeks 1 and 2 (p=0.036) were statistically significant.


CONCLUSIONS
The early healing phase of mucoperiosteal flaps is characterized by rapid capillary regeneration. OPS imaging enabled the possibility to monitor and quantify the temporal development of mucoperiosteal flap revascularization following periodontal surgery.
Milstein
Dan M J
DM
Department of Translational Physiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. d.m.milstein@amc.uva.nl
Mathura
Keshen R
KR
Lindeboom
Jérôme A H
JA
Ramsoekh
Dewkoemar
D
Lindeboom
Robert
R
Ince
Can
C
D000328:Adult; D016301:Alveolar Bone Loss / Q000601:surgery; D001672:Biocompatible Materials; D001861:Bone Regeneration / Q000502:physiology*; D016025:Bone Transplantation; D002196:Capillaries / Q000254:growth & development; D003094:Collagen; D003758:Dental Implantation, Endosseous; D015921:Dental Implants; D005260:Female; D005500:Follow-Up Studies; D005881:Gingiva / Q000098:blood supply; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008567:Membranes, Artificial; D008859:Microscopy, Polarization; D018919:Neovascularization, Physiologic / Q000502:physiology*; D010483:Periapical Diseases / Q000601:surgery; D010865:Pilot Projects; D011446:Prospective Studies; D013524:Surgical Flaps / Q000098:blood supply*; D013997:Time Factors; D020390:Tooth Socket / Q000601:surgery; D014945:Wound Healing / Q000502:physiology
C106416:Bio-Gide; D001672:Biocompatible Materials; D015921:Dental Implants; D008567:Membranes, Artificial; D003094:Collagen