Early features in frontotemporal dementia.
Frontotemporal dementia is a disorder of paralimbic prefrontal-insular circuitry. The disorder is often sporadic but can be caused by genetic mutations in tau, progranulin, valosin, TDP-43 and CHMP2b. The major clinical manifestations of FTD include addictive behaviors, disinhibition, apathy, overeating and loss of sympathy and empathy for others. Treatment is currently focused around symptoms but disease-modifying therapies seem feasible.
Caycedo
Ana María Villamizar
AM
Memory and Aging Center, Department of Neurology, UCSF, USA. krascovsky@memory.ucsf.edu
Miller
Bruce
B
Kramer
Joel
J
Rascovsky
Katya
K
D000342:Affective Symptoms / Q000503:physiopathology; D001284:Atrophy; D003072:Cognition Disorders / Q000503:physiopathology; D003704:Dementia / Q000175:diagnosis*; D005625:Frontal Lobe / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D013702:Temporal Lobe / Q000473:pathology* / Q000503:physiopathology