title: Bioactive Nortriterpenoids from Schisandra grandiflora.
abstract: Three new nortriterpenoids, schigrandilactones A-C (1-3), along with eight known compounds, were isolated from an organic solvent extract of Schisandra grandiflora. Compounds 1 and 2 feature a spirocyclic moiety in their structures, and compound 3 was characterized with a new oxygenated pattern. The relative configurations of 1 and 3 were determined through single-crystal X-ray experiments. In addition, compounds 1 and 2 displayed cytotoxic activity against two human cancer cell lines, and compound 3 showed anti-HIV-1 inhibition in infected C8166 cells.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, People's Republic of China.
authors.forename: Wei-Lie
authors.initials: WL
authors.lastname: Xiao
authors.forename: Yan-Qing
authors.initials: YQ
authors.lastname: Gong
authors.forename: Rui-Rui
authors.initials: RR
authors.lastname: Wang
authors.forename: Zhi-Ying
authors.initials: ZY
authors.lastname: Weng
authors.forename: Xiao
authors.initials: X
authors.lastname: Luo
authors.forename: Xiao-Nian
authors.initials: XN
authors.lastname: Li
authors.forename: Guang-Yu
authors.initials: GY
authors.lastname: Yang
authors.forename: Fei
authors.initials: F
authors.lastname: He
authors.forename: Jian-Xin
authors.initials: JX
authors.lastname: Pu
authors.forename: Liu-Meng
authors.initials: LM
authors.lastname: Yang
authors.forename: Yong-Tang
authors.initials: YT
authors.lastname: Zheng
authors.forename: Yang
authors.initials: Y
authors.lastname: Lu
authors.forename: Han-Dong
authors.initials: HD
authors.lastname: Sun
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D008968:Molecular Conformation; D015394:Molecular Structure; D032141:Schisandra / Q000737:chemistry*; D018609:Tibet; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D019380:Anti-HIV Agents; D004365:Drugs, Chinese Herbal; D014315:Triterpenes; C544366:schigrandilactone A; C544368:schigrandilactone B; C544367:schigrandilactone C