title: Characterisation of a novel conjugate of ibuprofen with 3-hydroxybutyric acid oligomers.
abstract: OBJECTIVE
  A conjugate of ibuprofen with 3-hydroxybutyric acid oligomers has been evaluated as a novel drug delivery model system.
  
  
  METHODS
  This paper focuses on the synthesis and the characterisation of the physicochemical properties of this conjugate, and on hydrolysis studies in aqueous buffers and simulated intestinal fluid. We also describe the development of an analytical method (HPLC) for hydrolysis studies of this compound.
  
  
  RESULTS
  The conjugate had high stability in aqueous solutions of pH 6-8 and underwent slow enzymatic hydrolysis.
  
  
  CONCLUSIONS
  This conjugate is not well suited for oral administration but might be considered a candidate for development of prodrug preparations for parenteral or topical sustained release.
authors.affiliation: Department of Pharmaceutical Technology, Medical University of Gdansk, Poland.
authors.forename: Pawel
authors.initials: P
authors.lastname: Stasiak
authors.forename: Carsten
authors.initials: C
authors.lastname: Ehrhardt
authors.forename: Maria
authors.initials: M
authors.lastname: Juzwa
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Sznitowska
mesh_terms: D020155:3-Hydroxybutyric Acid / Q000737:chemistry*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D003692:Delayed-Action Preparations; D004355:Drug Stability; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D007052:Ibuprofen / Q000008:administration & dosage / Q000737:chemistry*; D011355:Prodrugs / Q000737:chemistry; D012995:Solubility
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D003692:Delayed-Action Preparations; D011355:Prodrugs; D020155:3-Hydroxybutyric Acid; D007052:Ibuprofen