Oxidative mechanisms of brain dysfunction during sepsis.
Oxidative stress has drawn a lot of attention in the past few decades, since it has been reported to participate in the mechanism of many diseases. Therefore, it seemed to be a good rationale to aim oxidative stress on therapeutic research. Sepsis is a complex systemic syndrome characterized by an imbalance between pro- and anti-inflammatory responses to a pathogen; its pathophysiology is a dynamic process which involves components of the immune system, the coagulation pathway, parenchymal cells, and the endocrine and metabolic pathways. It is well characterized that oxidative stress plays a crucial role in sepsis development, but the relation between central nervous system dysfunction and oxidative stress during sepsis is not well understood. Thus, we here summarize the current knowledge on the role of free radicals in the development of brain dysfunction in sepsis focusing on oxidative damage and the redox control of brain inflammatory pathways.
Dal-Pizzol
Felipe
F
Laboratório de Fisiopatologia Experimental, Programa de Pós-graduação em Ciências da Saúde, Unidade Acadêmica de Ciências da Saúde, Universidade do Extremo Sul Catarinense, 88806-000 Criciúma, SC, Brazil.
Ritter
Cristiane
C
Cassol
Omar J
OJ
Rezin
Gislaine T
GT
Petronilho
Fabrícia
F
Zugno
Alexandra I
AI
Quevedo
João
J
Streck
Emilio L
EL
D000818:Animals; D001921:Brain / Q000378:metabolism / Q000503:physiopathology*; D006801:Humans; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D018805:Sepsis / Q000378:metabolism / Q000503:physiopathology*; D015398:Signal Transduction
Kidney Int. 2007 Sep;72(5):557-65
17538569
Arch Surg. 1989 Dec;124(12):1386-9
2589962
Ann N Y Acad Sci. 2002 Apr;959:263-74
11976201
Clin Sci (Lond). 1999 May;96(5):461-6
10209077
Proc Natl Acad Sci U S A. 1994 Nov 22;91(24):11393-7
7972071
Crit Care Med. 1993 Jan;21(1):98-103
8420739
Physiol Res. 2006;55(1):33-8
15857166
Blood. 1999 Mar 1;93(5):1464-76
10029572
J Neurosci. 2005 Apr 20;25(16):4082-90
15843610
Biochim Biophys Acta. 2006 Apr;1757(4):262-72
16626626
Arch Surg. 1986 Feb;121(2):196-208
3484944
J Hypertens. 1999 Sep;17(9):1249-56
10489101
Lab Invest. 2007 Dec;87(12):1186-94
17922019
Clin Invest Med. 1990 Dec;13(6):297-304
2078909
Biochemistry (Mosc). 2005 Feb;70(2):200-14
15807660
Neuroendocrinology. 1998 Feb;67(2):109-16
9508041
J Pharmacol Exp Ther. 2006 Apr;317(1):181-7
16368897
Mol Cell Biol. 1994 Jul;14(7):4443-54
8007951
Brain Res. 1999 Mar 13;821(2):322-32
10064818
Free Radic Biol Med. 2004 Aug 15;37(4):433-41
15256215
J Neurochem. 2001 Nov;79(3):648-57
11701768
Intensive Care Med. 2004 Nov;30(11):2009-16
15372146
Exp Neurol. 2008 Sep;213(1):114-21
18586243
Am J Respir Crit Care Med. 2001 May;163(6):1389-94
11371406
Neurol Res. 1998 Mar;20(2):100-6
9522343
Ann Trop Paediatr. 2000 Mar;20(1):27-33
10824210
Neurosci Lett. 2005 Mar 16;376(3):171-6
15721216
Am J Respir Crit Care Med. 2000 Aug;162(2 Pt 1):716-22
10934111
Proc Soc Exp Biol Med. 1987 Jun;185(2):206-10
3554261
Crit Care. 2005 Apr;9(2):145-6
15774066
Crit Care. 2005 Apr;9(2):R96-109
15774056
Curr Pharm Des. 2006;12(32):4123-34
17100615
Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1610-5
11818564
Intensive Care Med. 2003 Oct;29(10):1782-9
12783160
Neurology. 2002 Jan 22;58(2):186-91
11805243
Crit Care. 2006;10(6):238
17118217
Arch Biochem Biophys. 1985 Mar;237(2):408-14
2983613
Exp Mol Med. 2007 Aug 31;39(4):421-38
17934330
Br J Pharmacol. 2005 Jun;145(4):460-8
15806113
Brain Pathol. 2004 Jan;14(1):21-33
14997934
Internist (Berl). 1998 May;39(5):485-92
9647983
Neurochem Int. 1999 Feb;34(2):91-9
10213066
Exp Neurol. 2002 Jul;176(1):175-82
12093094
Crit Rev Biochem Mol Biol. 2007 May-Jun;42(3):113-85
17562450
Int J Biochem Cell Biol. 2005 Dec;37(12):2478-503
16103002
Am J Respir Crit Care Med. 2000 Jun;161(6):1907-11
10852765
Am Surg. 1997 Jan;63(1):20-3
8985066
N Engl J Med. 2003 Jan 9;348(2):138-50
12519925
J Alzheimers Dis. 2003 Apr;5(2):105-17
12719628
Intensive Care Med. 2004 Nov;30(11):1997-2008
15549252
Brain Res Brain Res Rev. 1999 Aug;30(2):153-63
10525172
J Neurosci. 2001 Sep 1;21(17):6480-91
11517237
J Neurochem. 2000 May;74(5):1989-98
10800942
Exp Physiol. 2007 Sep;92(5):807-11
17675415
FASEB J. 2002 Nov;16(13):1713-20
12409313
Annu Rev Immunol. 1997;15:351-69
9143692
J Clin Invest. 1995 Mar;95(3):1086-91
7883956
Glia. 1996 Feb;16(2):165-73
8929903
Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):9010-4
12060716
Am J Pathol. 1993 Apr;142(4):1265-78
8475997
Crit Care Med. 2008 Jun;36(6):1925-32
18496362
Free Radic Biol Med. 2003 Mar 15;34(6):766-73
12633753
Life Sci. 2008 May 23;82(21-22):1111-6
18452953
Neurochem Res. 2005 Jun-Jul;30(6-7):791-6
16187214
J Neuroinflammation. 2008 Sep 15;5:38
18793399
Cell. 2005 Jun 3;121(5):667-70
15935753
Adv Exp Med Biol. 2003;530:725-36
14562771
Nucleic Acids Res. 1999 Aug 1;27(15):3213-8
10454620
Nat Med. 1996 May;2(5):581-4
8616720
Anesthesiology. 2006 Oct;105(4):819-37
17006082
Brain Res. 1992 Aug 7;587(2):250-6
1381982
Cell Metab. 2005 Jun;1(6):401-8
16054089
Anesth Analg. 2001 Mar;92(3):681-7
11226101
Shock. 2004 May;21(5):458-65
15087823
Glia. 2000 Jan 1;29(1):1-13
10594918
J Endocrinol. 2003 Jul;178(1):5-12
12844330
Crit Care Med. 2007 Sep;35(9):2233-4
17713382
J Clin Invest. 1996 Jan 1;97(1):209-16
8550836
Crit Care Med. 1991 May;19(5):732-5
2026037
J Neurosci. 1999 May 15;19(10):3809-17
10234013
J Neurochem. 2006 Jun;97(6):1634-58
16805774
Brain Res. 2004 Sep 17;1021(1):20-31
15328028
Am J Respir Crit Care Med. 1998 Feb;157(2):421-7
9476853
Ann N Y Acad Sci. 2000;899:136-47
10863535
Nature. 1954 Oct 9;174(4432):689-91
13213980
Crit Care. 2004 Apr;8(2):R91-8
15025783
J Mol Cell Cardiol. 2001 Jun;33(6):1065-89
11444914
Am Surg. 1993 Jan;59(1):9-12
8480936
Crit Care Med. 2005 Dec;33(12 Suppl):S498-501
16340433
Biosci Rep. 1997 Feb;17(1):3-8
9171915
Intensive Care Med. 2000 Apr;26(4):474-6
10872143
Mitochondrion. 2008 Sep;8(4):313-8
18657632
Biochem J. 1980 Nov 1;191(2):421-7
6263247
Proc Natl Acad Sci U S A. 2008 May 27;105(21):7534-9
18490655
Free Radic Res. 2003 Jan;37(1):19-27
12653213
Neuroscience. 2006 Jul 21;140(4):1157-68
16713109
Mol Cell Biochem. 2003 May;247(1-2):83-94
12841635
Am J Emerg Med. 1991 Mar;9(2):139-43
1994941
J Surg Res. 1985 Mar;38(3):267-71
2858604
Ann Neurol. 1996 Mar;39(3):385-9
8602759
J Surg Res. 2007 Aug;141(2):252-6
17490683
Proc Natl Acad Sci U S A. 2007 Aug 21;104(34):13798-803
17693552
Ann Neurol. 2005 Oct;58(4):495-505
16178023
Exp Mol Med. 2007 Dec 31;39(6):812-9
18160852
Crit Care Med. 1989 May;17(5):399-403
2495896
Free Radic Res. 2006 Jul;40(7):685-95
16983995
Intensive Care Med. 2007 Jun;33(6):941-50
17410344
Free Radic Biol Med. 2007 Jan 15;42(2):153-64
17189821
Neuroimmunomodulation. 2005;12(5):255-69
16166805
FASEB J. 2000 Oct;14(13):1889-900
11023973
Gen Pharmacol. 1997 Aug;29(2):159-66
9251894
Cardiovasc Res. 1999 Mar;41(3):511-3
10435022
Am J Respir Crit Care Med. 1999 Jul;160(1):50-6
10390379
J Neurochem. 2000 Oct;75(4):1455-64
10987825
Biochim Biophys Acta. 1988 Dec 7;936(3):377-85
2848580
Intensive Care Med. 1990;16 Suppl 3:S192-6
2289989
Eur J Pharmacol. 2008 Jun 24;588(1):106-13
18499097
Crit Care Med. 2006 Mar;34(3):886-9
16505668
J Biol Chem. 2002 Aug 16;277(33):29584-92
12048217
Mol Aspects Med. 2004 Feb-Apr;25(1-2):125-39
15051322
Surgery. 1994 Nov;116(5):859-67
7940190
Fundam Clin Pharmacol. 2008 Apr;22(2):203-9
18353115
Int Arch Allergy Immunol. 1997 Dec;114(4):336-42
9414136
Mol Cell Biol. 2007 Jan;27(2):411-25
17074805
Clinics (Sao Paulo). 2006 Feb;61(1):71-6
16532228
Am J Physiol Regul Integr Comp Physiol. 2004 Mar;286(3):R491-7
14604843
Lancet. 2003 Nov 29;362(9398):1799-805
14654318
Crit Care Med. 2000 Nov;28(11):3599-605
11098960
Crit Care. 2005 Feb;9(1):37-44
15693982
Am J Physiol. 1999 Dec;277(6):H2240-6
10600842
Crit Care Med. 2000 Aug;28(8):3019-24
10966289
Am J Respir Crit Care Med. 2005 Feb 15;171(4):340-7
15542793
Mol Med. 1997 Nov;3(11):750-64
9407551
J Alzheimers Dis. 2005 Mar;8(4):369-75
16556968
Chem Biol Interact. 2006 Nov 7;163(3):207-17
16982041
Neurol Res. 1997 Aug;19(4):369-76
9263215
J Neurochem. 2008 Jul;106(2):770-80
18419763
Can J Neurol Sci. 2003 May;30(2):98-105
12774948
Trends Neurosci. 2000 Apr;23(4):175-80
10717677
Antioxid Redox Signal. 2005 May-Jun;7(5-6):829-34
15890031
Crit Care Med. 1999 Dec;27(12):2656-61
10628605
Prog Neurobiol. 2002 Jun;67(2):161-72
12126659
J Biol Chem. 2003 Sep 19;278(38):36027-31
12840017
J Neurochem. 1998 Jul;71(1):88-94
9648854
Glia. 2005 May;50(3):235-46
15739188
Annu Rev Biochem. 1995;64:97-112
7574505
Psychol Med. 1999 Mar;29(2):291-7
10218921
J Neurosci. 1998 Mar 1;18(5):1633-41
9464988
Br J Pharmacol. 1999 May;127(2):482-8
10385249
J Neuropathol Exp Neurol. 2001 Aug;60(8):759-67
11487050
Brain Res Mol Brain Res. 1997 Oct 3;49(1-2):238-46
9387883
J Infect Dis. 1994 Aug;170(2):457-60
8035037
Crit Care Med. 1990 Aug;18(8):801-6
2379391
Trends Biochem Sci. 2005 Aug;30(8):453-61
15996871
Neuron. 2006 Jan 5;49(1):67-79
16387640
Biochemistry. 2003 Apr 22;42(15):4520-6
12693948
Glia. 2008 Jul;56(9):1028-37
18381655
J Immunol. 1992 Oct 15;149(8):2736-41
1383325
J Neurochem. 2007 Aug;102(3):667-78
17403137
Am J Physiol Lung Cell Mol Physiol. 2000 Dec;279(6):L1005-28
11076791
J Immunol. 2008 Jul 1;181(1):680-9
18566435
Curr Infect Dis Rep. 2003 Oct;5(5):365-371
13678565
J Biol Chem. 2002 Aug 16;277(33):29626-33
12050154
Glia. 2005 Jun;50(4):329-39
15846802
Nature. 1990 Oct 25;347(6295):768-70
1700301
Behav Brain Res. 2006 Jul 15;171(1):94-108
16677721
Crit Care Med. 2005 Jan;33(1):221-3; discussion 262-3
15644673
J Neurochem. 2006 Sep;98(6):1852-65
16945104
J Neurochem. 2002 Jan;80(1):73-80
11796745
J Pharmacol Exp Ther. 2003 Jan;304(1):1-7
12490568
Crit Care Med. 1997 Oct;25(10):1700-6
9377885
Science. 1999 Mar 5;283(5407):1488-93
10066163