Diagnostic accuracy of community pathologists in the interpretation of colorectal polyps.
OBJECTIVE
Management of patients with endoscopically removed colorectal polyps is generally dependent on pathological evaluation. The aim of this study was to assess the accuracy and clinical impact of pathologic interpretation of colorectal polyps by community pathologists.


METHODS
Two expert gastrointestinal pathologists reviewed the slides of 300 colorectal polyps initially examined by 14 general pathologists. Polyps had been detected by a fecal occult blood test colorectal cancer screening program in Haut-Rhin, a French administrative district.


RESULTS
Villous histology was overread in 24.8% of cases and high-grade dysplasia in 22.0%. The diagnosis of serrated adenoma was confirmed in 15.7% of cases. The diagnosis of T1 carcinoma was overestimated in seven cases (17.9%) and missed in four. In the screening program, the proportion of correct diagnoses of community pathologists was estimated at 45.3% of polyps, of misclassification without clinical impact at 27.5%, and of misclassification with a theoretical impact on management at 27.2%, leading to over-surveillance in 20.3% of polyps and to unnecessary surgical resection in three individuals. Overall, 37.5% of the pathology reports of malignant polyps were complete, presenting all criteria necessary for therapeutic decision-making.


CONCLUSIONS
Community pathologists exhibited moderate accuracy for interpreting colorectal polyps, with an impact on patient management for around one out of five individuals. Our results confirm the intrinsic poor reliability of the pathologic interpretation of villous histology and high-grade dysplasia and suggest that these advanced pathologic features should be abandoned for clinical use. They illustrate the need for a clarification of the nomenclature of serrated polyps.
Denis
Bernard
B
Association pour le dépistage du cancer colorectal en Alsace (ADECA Alsace), Colmar Cedex, France. bernard.denis@ch-colmar.rss.fr
Peters
Carol
C
Chapelain
Catherine
C
Kleinclaus
Isabelle
I
Fricker
Anne
A
Wild
Richard
R
Augé
Bernard
B
Gendre
Isabelle
I
Perrin
Philippe
P
Chatelain
Denis
D
Fléjou
Jean François
JF
D018256:Adenomatous Polyps / Q000473:pathology / Q000601:surgery; D002983:Clinical Competence; D003111:Colonic Polyps / Q000473:pathology / Q000601:surgery; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000473:pathology / Q000601:surgery; D003937:Diagnosis, Differential; D003951:Diagnostic Errors; D005602:France; D006764:Hospitals, Community / Q000592:standards; D006801:Humans; D007417:Intestinal Polyps / Q000473:pathology* / Q000601:surgery; D008403:Mass Screening / Q000379:methods; D009780:Occult Blood; D010337:Pathology Department, Hospital / Q000592:standards; D011230:Precancerous Conditions / Q000473:pathology / Q000601:surgery; D011237:Predictive Value of Tests; D012002:Rectal Diseases / Q000473:pathology / Q000601:surgery