title: New cyclodextrin derivative 6-O-(2-hydroxybutyl)-beta-cyclodextrin: preparation and its application in molecular binding and recognition.
abstract: A new soluble cyclodextrin derivative 6-O-(2-hydroxybutyl)-beta-cyclodextrin (6-HB-beta-CD) was prepared. Its molecular binding and recognition ability were investigated with the comparison of beta-cyclodextrin (beta-CD), 2-O-(2-hydroxypropyl)-beta-cyclodextrin (2-HP-beta-CD), 6-O-(2-hydroxypropyl)-beta-cyclodextrin (6-HP-beta-CD), and 2-O-(2-hydroxybutyl)-beta-cyclodextrin (2-HB-beta-CD). The relationship between the complex stability constants and the possible structures of inclusion compounds was discussed with the interaction of hosts and guests, including the weak hydrophobic interactions, the size/shape matching, the steric hindrance, and the hydrophilic property.
authors.affiliation: Shandong University, Jinan, PR China.
authors.forename: Hong Yuan
authors.initials: HY
authors.lastname: Sun
authors.forename: Yan
authors.initials: Y
authors.lastname: Bai
authors.forename: Ming Gang
authors.initials: MG
authors.lastname: Zhao
authors.forename: Ai You
authors.initials: AY
authors.lastname: Hao
authors.forename: Gui Ying
authors.initials: GY
authors.lastname: Xu
authors.forename: Jian
authors.initials: J
authors.lastname: Shen
authors.forename: Jian Ye
authors.initials: JY
authors.lastname: Li
authors.forename: Tao
authors.initials: T
authors.lastname: Sun
authors.forename: Hua Cheng
authors.initials: HC
authors.lastname: Zhang
mesh_terms: D002942:Circular Dichroism; D004852:Epoxy Compounds / Q000737:chemistry; D015394:Molecular Structure; D047392:beta-Cyclodextrins / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D004852:Epoxy Compounds; D047392:beta-Cyclodextrins; C027488:1,2-epoxybutane; C031215:betadex