[Application of Doehlert design for compatibility research of Dachengqi decoction].
OBJECTIVE
To study the compatibility of dosage change of Zhishi, Houpo and Mangxiao affecting the yields of Anthraquinone components in Dachengqi decoction.


METHODS
Response surface methodology (RSM) with Doehlert design was adopted to evaluate the yields of Anthraquinone components in Dachengqi decoction by dosage change of Zhishi, Houpo and Mangxiao and the analysis time was shorten through a desirability function.


RESULTS
Results show that Anthraquinone components were got a high yields when the dosage ratio of Dachengqi decoction were compatible as follows: Dahuang-Zhishi-Houpo-Mangxiao (1:4:2. 31:2).


CONCLUSIONS
The Doehlert design with a desirability function, which allow a sequential response methodology, is a good methods, and, of cause, the mathematical model can be further extended and applied to the compatibility research of Chinese material medicine.
Xie
Zhen
Z
Department of Chinese Material Medicine Analysis, Guangzhou University of Chinese Medicine, Guangzhou 510006, China. xie_zhen@126.com
Cao
Cheng
C
Zeng
Yuaner
Y
Jiang
Bin
B
D000880:Anthraquinones / Q000032:analysis; D004304:Dosage Forms; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000737:chemistry; D008956:Models, Chemical; D010936:Plant Extracts / Q000008:administration & dosage* / Q000737:chemistry*
D000880:Anthraquinones; D004304:Dosage Forms; D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; C477169:dachengqi decoction