Vitamin B12 status in patients of Turkish and Dutch descent with depression: a comparative cross-sectional study.
BACKGROUND
Studies have shown a clear relationship between depressive disorders and vitamin B12 deficiency. Gastroenteritis and Helicobacter pylori infections can cause vitamin B12 deficiency. Helicobacter pylori infections are not uncommon among people of Turkish descent in The Netherlands.


OBJECTIVE
To examine the frequency of vitamin B12 deficiency in depressive patients of Turkish descent and compare it to the frequency of vitamin B12 deficiency in depressive patients of Dutch descent.


METHODS
The present study is a comparative cross-sectional study of 47 patients of Turkish descent and 28 of Dutch descent. The depressive disorder diagnosis and differential diagnosis were made using the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, fourth edition text revision (SCID). The severity of the depressive symptoms was determined using the Beck Depression Inventory (BDI) and the 21-item Hamilton Depression Rating Scale (HAM-D-21). Serum baseline vitamin B6 and B12, folic acid and total serum homocysteine (tHcy) levels were measured.


RESULTS
The average ages of the patients of Turkish and Dutch descent were 40.57 and 44.75 years, respectively. There were no demonstrable differences between the serum vitamin B6, folic acid and tHcy levels in the two groups. The serum vitamin B12 levels were however clearly lower in the patients of Turkish descent than in those of Dutch descent. Vitamin B12 deficiency was however observed in 14 patients of Turkish descent and 1 of Dutch descent. This difference was significant. On the BDI, the patients of Turkish descent scored significantly higher than those of Dutch descent. Patients with vitamin B12 deficiency and those with hyperhomocysteinaemia had a significantly higher BDI score than patients with normal vitamin B12 and homocysteine levels. No relationship was observed with vitamin B12 and tHcy.


CONCLUSIONS
Vitamin B12 deficiency occurs more frequently in depressive patients of Turkish than of Dutch descent. This is why it is advisable to test the vitamin B12 serum level in depressive patients of Turkish descent.
Güzelcan
Yener
Y
Department of Psychiatry, Erasmus MC, University Medical Centre, Rotterdam, The Netherlands. yguzelcan@riaggrijnmond.nl
van Loon
Peter
P
Helicobacter. 2002 Dec;7(6):337-41
12485119
Am J Psychiatry. 2006 Jun;163(6):969-78
16741195
Nutrition. 1995 Mar-Apr;11(2):181; discussion 180, 182
7647490
Am J Clin Nutr. 1996 Mar;63(3):306-14
8602585
Mol Psychiatry. 2007 Apr;12(4):331-59
17389902
J Affect Disord. 2004 Sep;81(3):269-73
15337331
Dig Dis Sci. 2003 Sep;48(9):1846-9
14561012
J Clin Psychiatry. 2008 Aug;69(8):1203-9
18557664
Eur J Clin Nutr. 2008 Aug;62(8):939-45
17538543
Mol Psychiatry. 2008 Jul;13(7):709-16
18347599
Am J Clin Nutr. 2000 Feb;71(2):614S-620S
10681269
Arch Intern Med. 2000 May 8;160(9):1349-53
10809040
Am J Psychiatry. 2007 Jun;164(6):861-7
17541043
Ned Tijdschr Geneeskd. 2003 Jul 5;147(27):1308-13
12868158
J Psychopharmacol. 2005 Jan;19(1):59-65
15671130
J Psychosom Res. 2000 Sep;49(3):183-7
11110989
J Ren Nutr. 2007 Sep;17(5):343-9
17720104
Neth J Med. 2001 Nov;59(5):209-12
11705639
Compr Psychiatry. 1997 Nov-Dec;38(6):305-14
9406735
Proc Natl Acad Sci U S A. 1997 May 27;94(11):5923-8
9159176
Int Psychogeriatr. 2002 Dec;14(4):331-4
12670055
Am J Psychiatry. 2000 May;157(5):715-21
10784463
Br J Soc Clin Psychol. 1967 Dec;6(4):278-96
6080235
Scand J Gastroenterol. 2008;43(4):403-9
18365904
Med Hypotheses. 1994 Oct;43(4):239-44
7838008
Biol Psychol. 2001 Jun;56(3):247-65
11399353
Am J Psychiatry. 2002 Dec;159(12):2099-101
12450964
Mod Probl Pharmacopsychiatry. 1974;7(0):151-69
4412100
BMC Psychiatry. 2003 Dec 02;3:17
14641930
Gen Hosp Psychiatry. 2008 Mar-Apr;30(2):185-6
18291301
Br J Psychiatry. 2008 Apr;192(4):268-74
18378986
Turk J Gastroenterol. 2003 Mar;14(1):44-9
14593537
Eur J Clin Invest. 1996 Oct;26(10):853-9
8911857