Breast cancer stem cells: eradication by differentiation therapy?
During metastasis, migrating breast cancer stem cells undergo a loss of polarity leading to an epithelial-to-mesenchymal transition (EMT). Gupta et al. (2009) use this attribute of cancer stem cells to develop a high-throughput screen, which successfully identifies small molecules that specifically inhibit cancer stem cell proliferation through the induction of differentiation.
Beug
Hartmut
H
The Institute of Molecular Pathology, Dr. Bohrgasse 7, A 1030 Vienna, Austria. beug@imp.ac.at
D000818:Animals; D001943:Breast Neoplasms / Q000188:drug therapy*; D002454:Cell Differentiation; D004847:Epithelial Cells / Q000166:cytology; D006801:Humans; D014411:Neoplastic Stem Cells / Q000187:drug effects*