title: Epidermal growth factor receptor-regulated miR-125a-5p--a metastatic inhibitor of lung cancer.
abstract: Both the epidermal growth factor receptor signaling pathway and microRNA (miRNA) play an important role in lung cancer development and progression. To address the potential role of miRNA in epidermal growth factor receptor signaling, we identified miR-125a-5p as a downstream target, using an miRNA array. We further demonstrated that miR-125a-5p inhibited migration and invasion of lung cancer cells. Moreover, miR-125a-5p regulated the expression of several downstream genes of epidermal growth factor receptor signaling. Importantly, examination of lung cancer samples revealed a significant correlation of miR-125a-5p repression with lung carcinogenesis. Taken together, our results provide compelling evidence that miR-125a-5p, an epidermal growth factor-signaling-regulated miRNA, may function as a metastatic suppressor.
authors.affiliation: Department of Respiratory Disease, Zhejiang Hospital, Hangzhou, China.
authors.forename: Guofu
authors.initials: G
authors.lastname: Wang
authors.forename: Weimin
authors.initials: W
authors.lastname: Mao
authors.forename: Shu
authors.initials: S
authors.lastname: Zheng
authors.forename: Jingjia
authors.initials: J
authors.lastname: Ye
mesh_terms: D045744:Cell Line, Tumor; D002465:Cell Movement / Q000235:genetics; D002470:Cell Survival; D066246:ErbB Receptors / Q000378:metabolism*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000378:metabolism* / Q000556:secondary; D020935:MAP Kinase Signaling System; D035683:MicroRNAs / Q000037:antagonists & inhibitors / Q000235:genetics*; D009361:Neoplasm Invasiveness / Q000235:genetics; D016372:RNA, Antisense / Q000235:genetics; D012334:RNA, Neoplasm / Q000235:genetics*; D015398:Signal Transduction
chemical_list: C531888:MIRN125 microRNA, human; D035683:MicroRNAs; D016372:RNA, Antisense; D012334:RNA, Neoplasm; D066246:ErbB Receptors
references.citation: Cancer Res. 2005 Aug 15;65(16):7065-70
references.pmid: 16103053
references.citation: J Biol Chem. 2007 Jan 12;282(2):1479-86
references.pmid: 17110380
references.citation: Cancer Cell. 2007 Nov;12(5):414-8
references.pmid: 17996645
references.citation: Bioorg Med Chem Lett. 2001 Jul 23;11(14):1911-4
references.pmid: 11459659
references.citation: Mol Cancer. 2006 Jun 19;5:24
references.pmid: 16784538
references.citation: Nat Cell Biol. 2008 May;10(5):593-601
references.pmid: 18376396
references.citation: Nature. 2007 Oct 11;449(7163):682-8
references.pmid: 17898713
references.citation: Clin Cancer Res. 2006 Dec 15;12(24):7242-51
references.pmid: 17189395
references.citation: Cell. 1988 Jul 1;54(1):105-15
references.pmid: 2898299
references.citation: Ann Thorac Surg. 1995 Aug;60(2):466-72
references.pmid: 7646126
references.citation: Mol Cancer Res. 2003 Oct;1(12):882-91
references.pmid: 14573789
references.citation: Endocr Relat Cancer. 2001 Mar;8(1):11-31
references.pmid: 11350724
references.citation: Mol Cancer Ther. 2004 Apr;3(4):465-72
references.pmid: 15078990
references.citation: FEBS Lett. 2008 Oct 29;582(25-26):3663-8
references.pmid: 18840437
references.citation: Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15524-9
references.pmid: 12434020
references.citation: Clin Cancer Res. 2001 Jul;7(7):1850-5
references.pmid: 11448895
references.citation: Nat Rev Cancer. 2006 Nov;6(11):857-66
references.pmid: 17060945
references.citation: Cancer Res. 2005 Jan 1;65(1):226-35
references.pmid: 15665299
references.citation: CA Cancer J Clin. 2007 Jan-Feb;57(1):43-66
references.pmid: 17237035
references.citation: Science. 2005 Nov 25;310(5752):1330-3
references.pmid: 16239437