title: Phase-contrast diffuse optical tomography for in vivo breast imaging: a two-step method.
abstract: We present a two-step reconstruction method that can qualitatively and quantitatively improve the reconstruction of tissue refractive index (RI) distribution by phase-contrast diffuse optical tomography (PCDOT). In this two-step method, we first recover the distribution of tissue absorption and scattering coefficients by conventional diffuse optical tomography to obtain the geometrical information of lesions, allowing the incorporation of geometrical information as a priori in the PCDOT reconstruction using a locally refined mesh. The method is validated by a series of phantom experiments and evaluated using in vivo data from 42 human subjects. The results demonstrate clear contrast of RI between the lesion and the surroundings, making the image interpretation straightforward. The sensitivity and specificity from these 42 cases are both 81% when RI is used as an imaging parameter for distinguishing between malignant and benign lesions.
authors.affiliation: The J. Crayton Pruitt Family, Department of Biomedical Engineering, University of Florida, Gainesville, Florida 32611, USA.
authors.forename: Ruixin
authors.initials: R
authors.lastname: Jiang
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Liang
authors.forename: Qizhi
authors.initials: Q
authors.lastname: Zhang
authors.forename: Stephen
authors.initials: S
authors.lastname: Grobmyer
authors.forename: Laurie L
authors.initials: LL
authors.lastname: Fajardo
authors.forename: Huabei
authors.initials: H
authors.lastname: Jiang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D001940:Breast / Q000473:pathology*; D001943:Breast Neoplasms / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods / Q000706:statistics & numerical data; D008875:Middle Aged; D055620:Optical Phenomena; D019047:Phantoms, Imaging; D012680:Sensitivity and Specificity; D041622:Tomography, Optical / Q000379:methods* / Q000706:statistics & numerical data