Chemical methods for the synthesis and modification of neoclerodane diterpenes.
Diterpenes are a structural class of molecules that are derived from four isoprene subunits and are widespread throughout nature. A number of neoclerodane diterpenes have been found to have biological activity but a limited number of chemical investigations have been conducted. Recently, the neoclerodane diterpene, salvinorin A (12) has been investigated due to its unique pharmacological profile. This review will discuss the chemical methods used to chemically modify and synthesize 12.
Lozama
Anthony
A
Division of Medicinal & Natural Products Chemistry, College of Pharmacy, The University of Iowa, Iowa City, IA 52240, USA.
Prisinzano
Thomas E
TE
D045785:Diterpenes, Clerodane / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure; D027544:Salvia / Q000737:chemistry
D045785:Diterpenes, Clerodane; C090499:salvinorin A
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