title: Outcome in women with no endocervical component on cervical cytology after treatment for high-grade cervical dysplasia.
abstract: BACKGROUND
  Cervical cancer and its precursors still remain an important cause of morbidity and mortality despite adequate screening programs. It is now established practice in Australia that a Pap smear without an endocervical component, which is otherwise negative, does not warrant an earlier repeat smear. This study aims to determine if the lack of an endocervical component in women with previously treated high-grade abnormalities of the cervix increases the risk of subsequent cytological abnormalities.
  
  
  METHODS
  Data were retrieved from an electronic database in the Oncology and Dysplasia Unit at The Royal Women's Hospital in Melbourne, Australia. Women who underwent treatment for high-grade cervical abnormalities from 2000-2004 were included in the study. Women with negative cytology immediately after their operations were first identified, and the incidence of subsequent cytological abnormalities was calculated and then separated according to their endocervical status.
  
  
  RESULTS
  Of the 1260 women in the study population, seven developed high-grade abnormalities (six with an endocervical component and one without) and 107 developed low-grade abnormalities (98 with an endocervical component and nine without).
  
  
  CONCLUSIONS
  The lack of an endocervical component was not statistically significantly associated with a higher incidence of either high-grade or low-grade abnormalities. Therefore, women who have had previous treatments for high-grade abnormalities do not need to have earlier repeat smears or intervention if the cytology lacks an endocervical component.
authors.affiliation: Department of Oncology and Dysplasia, Royal Women's Hospital, Parkville, Victoria, Australia. alihuang@bigpond.net.au
authors.forename: Alice
authors.initials: A
authors.lastname: Huang
authors.forename: Michael
authors.initials: M
authors.lastname: Quinn
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Tan
mesh_terms: D001315:Australia / Q000453:epidemiology; D002584:Cervix Uteri / Q000473:pathology*; D003584:Cytological Techniques / Q000379:methods; D005069:Evaluation Studies as Topic; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D065006:Papanicolaou Test; D012042:Registries; D012307:Risk Factors; D013997:Time Factors; D002578:Uterine Cervical Dysplasia / Q000150:complications / Q000473:pathology* / Q000628:therapy / Q000453:epidemiology; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology / Q000473:pathology* / Q000517:prevention & control; D014626:Vaginal Smears / Q000379:methods* / Q000706:statistics & numerical data