The determinants of susceptibility/resistance to adjuvant arthritis in rats.
Adjuvant arthritis (AA) serves as an excellent model for human rheumatoid arthritis. AA is readily inducible in certain rat strains, but not in others. Susceptibility/resistance to AA is determined by multiple factors. Among the genetic factors, both MHC and non-MHC genes contribute to arthritis susceptibility, and specific quantitative trait loci show association with the severity of the disease. Differential T-cell proliferative and cytokine responses, as well as antibody responses, to heat-shock proteins are evident when comparing AA-susceptible and AA-resistant rats. In addition, neuroendocrine factors and the housing environment can further modulate arthritis susceptibility/severity in particular rat strains.
Kim
Eugene Y
EY
Department of Microbiology and Immunology, University of Maryland School of Medicine, 660 West Redwood Street, Baltimore, MD 21201, USA. eyk21@hotmail.com
Moudgil
Kamal D
KD
D000818:Animals; D001169:Arthritis, Experimental / Q000235:genetics* / Q000276:immunology*; D020022:Genetic Predisposition to Disease; D006801:Humans; D051381:Rats
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