title: Differences in effects of Zuojin Pills and its similar formulas on Wei cold model in rats.
abstract: OBJECTIVE
  To explore the effects of Zuojin Pills and its similar formulas on the stomach cold syndrome in a Wei cold model in rats.
  
  
  METHODS
  The rat Wei cold model was established by intragastric administration of glacial NaOH, and the gastric mucosa injury indices, together with the levels of motilin and gastrin in the stomach, were determined. The preventive and curative effects of Zuojin Pills and its similar formulas on gastric mucosa injury were investigated.
  
  
  RESULTS
  Zuojin Pills and its similar formulas could protect the gastric mucosa in the gastric cold model in rats at different levels. Fanzuojin Pills had the best effect in inhibiting gastric mucosa injury.
  
  
  CONCLUSIONS
  The different pharmacological effects of Zuojin Pills and its similar formulas in the rat gastric cold model were partially correlated with the degrees in cold and heat properties of the formulas.
authors.affiliation: Institute of Traditional Chinese Material Medica, the 302 Hospital of PLA, Beijing, 100039, China.
authors.forename: Yan-ling
authors.initials: YL
authors.lastname: Zhao
authors.forename: Wen-li
authors.initials: WL
authors.lastname: Shi
authors.forename: Li-mei
authors.initials: LM
authors.lastname: Shan
authors.forename: Jia-bo
authors.initials: JB
authors.lastname: Wang
authors.forename: Hai-ping
authors.initials: HP
authors.lastname: Zhao
authors.forename: Xiao-he
authors.initials: XH
authors.lastname: Xiao
mesh_terms: D000818:Animals; D002626:Chemistry, Pharmaceutical; D003080:Cold Temperature; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000187:drug effects / Q000473:pathology; D008315:Malondialdehyde / Q000097:blood; D051381:Rats; D017207:Rats, Sprague-Dawley; D013272:Stomach Diseases / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D013482:Superoxide Dismutase / Q000097:blood; D013607:Tablets; D013810:Therapeutic Equivalency
chemical_list: D004365:Drugs, Chinese Herbal; D013607:Tablets; C545320:zuojin; D008315:Malondialdehyde; D013482:Superoxide Dismutase
references.citation: J Gastroenterol. 2001 Apr;36(4):231-6
references.pmid: 11324725
references.citation: J Physiol Pharmacol. 2002 Mar;53(1):39-50
references.pmid: 11939718
references.citation: World J Gastroenterol. 2005 May 14;11(18):2830-3
references.pmid: 15884133