TBD-organocatalysed synthesis of pyrazolines.
It was found that TBD, a cheap and commercially available guanidine, easily catalysed the synthesis of biologically important 3,5-diarylpyrazolines from chalcones and acylhydrazines via a selective secondary amine alkylation.
Mahé
Olivier
O
INSA et Université de Rouen, UMR CNRS COBRA, rue Tesnière, BP 08, 76131, Mont-Saint-Aignan, France.
Frath
Denis
D
Dez
Isabelle
I
Marsais
Francis
F
Levacher
Vincent
V
Brière
Jean-François
JF
D000478:Alkylation; D002384:Catalysis; D019791:Guanidine / Q000737:chemistry*; D006834:Hydrazines / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D006834:Hydrazines; D011720:Pyrazoles; D019791:Guanidine