Quantitative optical tomography of sub-surface heterogeneities using spatially modulated structured light.
We present a wide-field method for obtaining three-dimensional images of turbid media. By projecting patterns of light of varying spatial frequencies on a sample, we reconstruct quantitative, depth resolved images of absorption contrast. Images are reconstructed using a fast analytic inversion formula and a novel correction to the diffusion approximation for increased accuracy near boundaries. The method provides more accurate quantification of optical absorption and higher resolution than standard diffuse reflectance measurements.
Konecky
Soren D
SD
Laser Microbeam and Medical Program (LAMMP), Beckman Laser Institute, University of California - Irvine, 1002 Health Sciences Road, Irvine, CA 92617, USA.
Mazhar
Amaan
A
Cuccia
David
D
Durkin
Anthony J
AJ
Schotland
John C
JC
Tromberg
Bruce J
BJ
D000042:Absorption; D003952:Diagnostic Imaging / Q000379:methods; D004867:Equipment Design; D005583:Fourier Analysis; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008027:Light; D015233:Models, Statistical; D009391:Nephelometry and Turbidimetry; D055095:Optics and Photonics; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D013499:Surface Properties; D041622:Tomography, Optical / Q000295:instrumentation* / Q000379:methods*
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