title: Imaging of macroaneurysms occurring during retinal vein occlusion and diabetic retinopathy by indocyanine green angiography and high resolution optical coherence tomography.
abstract: BACKGROUND
  Macular edema occurring after retinal vein occlusion (RVO) or diabetic retinopathy (DR) may be due to the development of capillary and/or venous macroaneurysms (MAs). Here, we investigated the respective contribution of fluorescein angiography (FA), of indocyanine green angiography (ICGA) and of high-resolution optical coherence tomography (HR-OCT) to their detection.
  
  
  METHODS
  Review of the charts of six consecutive patients with MAs secondary to RVO (n = 4) or DR (n = 2). For each patient, FA, ICGA and HR-OCT data were analyzed and compared.
  
  
  RESULTS
  All detectable MAs were detected by ICGA, while in three eyes FA failed to show them. Overall, ICGA provided a better delineation of MAs than FA. In all cases, HR-OCT identified MAs under the form of a vascular structure with a reflective wall surrounding a lumen containing variably reflective material.
  
  
  CONCLUSIONS
  MAs can develop during the course of RVO and DR. ICGA and HR-OCT improves the identification of capillary and venous MAs, and may thus be of interest to better identify sites of blood-retinal barrier rupture during chronic macular edema due to RVO or DR.
authors.affiliation: Department of Ophthalmology of the Fondation Ophtalmologique Rothschild, Université Pierre et Marie Curie Paris6, 75019 Paris, France.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Bourhis
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Girmens
authors.forename: Severin
authors.initials: S
authors.lastname: Boni
authors.forename: Florence
authors.initials: F
authors.lastname: Pecha
authors.forename: Catherine
authors.initials: C
authors.lastname: Favard
authors.forename: José-Alain
authors.initials: JA
authors.lastname: Sahel
authors.forename: Michel
authors.initials: M
authors.lastname: Paques
mesh_terms: D000368:Aged; D000783:Aneurysm / Q000209:etiology / Q000473:pathology*; D000792:Angiography / Q000379:methods*; D004396:Coloring Agents; D003930:Diabetic Retinopathy / Q000150:complications / Q000473:pathology*; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D007208:Indocyanine Green; D007834:Lasers; D008269:Macular Edema / Q000209:etiology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D019721:Ophthalmoscopes; D012170:Retinal Vein Occlusion / Q000150:complications / Q000473:pathology*; D012171:Retinal Vessels / Q000473:pathology; D041623:Tomography, Optical Coherence / Q000379:methods*
chemical_list: D004396:Coloring Agents; D007208:Indocyanine Green
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