[Helicobacter pylori in children and association with CagA strains in mother-child transmission in the Brazilian Amazon region].
The prevalence of Helicobacter pylori infection was investigated in blood samples from 100 children aged 1 to 12 years and from their mothers, by means of the indirect hemagglutination and anti-CagA methods, using ELISA assays. From these 100 children, 79 stool samples were obtained and bacterial antigens in the stools were investigated using capture ELISA. The antigens were detected in 54.4% (43/79) of the children, and serum antibodies in 43% (34/79). These methods presented similar performance, with greatest disagreement among the children aged 1 to 4 years. The seroprevalence was 50% (50/100) among the children and 86% (86/100) among the mothers. Infected mothers represented a risk factor that was 19 times greater than that of seronegative mothers, with regard to infecting their children (p < 0.05), especially the mothers with CagA+ strains (p < 0.05). Direct person-to-person contact may be a transmission method for this infection.
Cartágenes
Vivian D'Annibale
VD
Núcleo de Vigilância Epidemiológica, Hospital Universitário João de Barros Barreto, Universidade Federal do Pará, Belém, PA. vivi_aslan@yahoo.com.br
Martins
Luísa Carício
LC
Carneiro
Lígia Maia
LM
Barile
Katarine Antonia dos Santos
KA
Corvelo
Tereza Cristina
TC
D000942:Antigens, Bacterial / Q000097:blood*; D001426:Bacterial Proteins / Q000097:blood*; D001938:Brazil / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005243:Feces / Q000382:microbiology; D005260:Female; D016481:Helicobacter Infections / Q000175:diagnosis / Q000453:epidemiology / Q000635:transmission*; D016480:Helicobacter pylori / Q000276:immunology* / Q000302:isolation & purification; D006386:Hemagglutination Tests; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D007223:Infant; D008297:Male; D015995:Prevalence
D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D007074:Immunoglobulin G; C080866:cagA protein, Helicobacter pylori