title: Endolymphatic hydrops revealed by intravenous gadolinium injection in patients with Ménière's disease.
abstract: CONCLUSIONS
  Visualization of endolymphatic hydrops became possible after intravenous gadolinium (Gd) injection in patients with Ménière's disease.
  
  
  OBJECTIVE
  To visualize endolymphatic hydrops after intravenous Gd injection.
  
  
  METHODS
  Gd (gadoteridol; 0.2 mmol/kg) was injected intravenously in three patients with unilateral Ménière's disease. We performed three-dimensional fluid attenuated inversion recovery (3D-FLAIR) and three-dimensional real inversion recovery (3D-real IR) magnetic resonance imaging (MRI) 4 h after the injection using a 3-Tesla MRI unit. We used a 32-channel array coil to obtain a high signal-to-noise ratio.
  
  
  RESULTS
  Endolymphatic hydrops was observed in the ears of patients with Ménière's disease. However, Gd concentration in the perilymph was lower compared with that obtained after intratympanic Gd injection.
authors.affiliation: Department of Otorhinolaryngology, Nagoya University, Nagoya, Japan. tsutomun@med.nagoya-u.ac.jp
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Nakashima
authors.forename: Shinji
authors.initials: S
authors.lastname: Naganawa
authors.forename: Masaaki
authors.initials: M
authors.lastname: Teranishi
authors.forename: Mitsuhiko
authors.initials: M
authors.lastname: Tagaya
authors.forename: Seiichi
authors.initials: S
authors.lastname: Nakata
authors.forename: Michihiko
authors.initials: M
authors.lastname: Sone
authors.forename: Hironao
authors.initials: H
authors.lastname: Otake
authors.forename: Ken
authors.initials: K
authors.lastname: Kato
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Iwata
authors.forename: Naoki
authors.initials: N
authors.lastname: Nishio
mesh_terms: D000328:Adult; D000368:Aged; D003051:Cochlea / Q000473:pathology; D003287:Contrast Media; D018159:Endolymphatic Hydrops / Q000175:diagnosis*; D005260:Female; D005682:Gadolinium; D006319:Hearing Loss, Sensorineural / Q000175:diagnosis; D006571:Heterocyclic Compounds; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D007275:Injections, Intravenous; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008575:Meniere Disease / Q000175:diagnosis*; D008875:Middle Aged; D009464:Neuroma, Acoustic / Q000473:pathology; D009942:Organometallic Compounds; D014722:Vestibule, Labyrinth / Q000473:pathology
chemical_list: D003287:Contrast Media; D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; C062402:gadoteridol; D005682:Gadolinium