title: Serum triglyceride concentrations and cancer risk in a large cohort study in Austria.
abstract: BACKGROUND
  Blood lipid levels as part of the metabolic syndrome are thought to be linked to cancer risk. Few epidemiological studies have addressed the association between serum triglyceride (STG) concentrations and cancer risk.
  
  
  METHODS
  Serum triglyceride concentrations were collected in a health investigation (1988-2003). The analyses included 156 153 subjects (71 693 men and 84 460 women), with 5079 incident cancers in men and 4738 cancers in women, and an average of 10.6 years of follow-up. All malignancies were ascertained from the population cancer registry. Multivariate Cox proportional hazard models stratified by age and sex were used to determine adjusted cancer risk estimates and 95% confidence interval (95% CI).
  
  
  RESULTS
  In men and women combined, higher STG concentrations were associated with increased risk of lung (4th vs 1st quartile: HR, 1.94; 95% CI, 1.47-2.54), rectal (HR, 1.56; 95% CI, 1.00-2.44), and thyroid cancer (HR, 1.96; 95% CI, 1.00-3.84). Serum triglyceride concentrations were inversely associated with non-Hodgkin's lymphoma. In men, STG concentrations were inversely associated with prostate cancer and positively with renal cancer. In women, STG concentrations were positively associated with gynaecological cancers. Stratification by BMI revealed a higher risk of gynaecological cancers in overweight than in normal weight women. No other associations were found.
  
  
  CONCLUSIONS
  Our findings support the hypothesis that STG concentrations are involved in the pathogenesis of lung, rectal, thyroid, prostate, and gynaecological cancers.
authors.affiliation: Department of Medical Statistics, Informatics and Health Economics, Innsbruck Medical University, Innsbruck, Austria.
authors.forename: H
authors.initials: H
authors.lastname: Ulmer
authors.forename: W
authors.initials: W
authors.lastname: Borena
authors.forename: K
authors.initials: K
authors.lastname: Rapp
authors.forename: J
authors.initials: J
authors.lastname: Klenk
authors.forename: A
authors.initials: A
authors.lastname: Strasak
authors.forename: G
authors.initials: G
authors.lastname: Diem
authors.forename: H
authors.initials: H
authors.lastname: Concin
authors.forename: G
authors.initials: G
authors.lastname: Nagel
mesh_terms: D000328:Adult; D000368:Aged; D015331:Cohort Studies; D005260:Female; D005833:Genital Neoplasms, Female / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000209:etiology*; D011471:Prostatic Neoplasms / Q000209:etiology; D012306:Risk; D014280:Triglycerides / Q000097:blood*
chemical_list: D014280:Triglycerides
references.citation: Lancet. 2008 Feb 16;371(9612):569-78
references.pmid: 18280327
references.citation: Nature. 2006 Dec 14;444(7121):881-7
references.pmid: 17167477
references.citation: Nat Rev Cancer. 2004 Aug;4(8):579-91
references.pmid: 15286738
references.citation: Circulation. 1998 Mar 24;97(11):1027-8
references.pmid: 9531247
references.citation: N Engl J Med. 2007 Sep 6;357(10):1009-17
references.pmid: 17804845
references.citation: J Lipid Res. 2004 Jul;45(7):1169-96
references.pmid: 15102878
references.citation: Nutr Metab Cardiovasc Dis. 2010 Jan;20(1):41-8
references.pmid: 19361966
references.citation: Arch Intern Med. 2008 Oct 27;168(19):2146-53
references.pmid: 18955645
references.citation: Diabetologia. 2006 May;49(5):945-52
references.pmid: 16557372
references.citation: J Chronic Dis. 1974 Mar;27(3):103-14
references.pmid: 4830839
references.citation: Circulation. 2007 Jan 30;115(4):450-8
references.pmid: 17190864
references.citation: Cancer Res. 2007 Jun 1;67(11):5569-74
references.pmid: 17522388
references.citation: J Natl Cancer Inst. 2004 Aug 4;96(15):1152-60
references.pmid: 15292387
references.citation: Circulation. 2008 Nov 11;118(20):2047-56
references.pmid: 18955664
references.citation: Am J Med. 2002 Dec 30;113 Suppl 9B:63S-70S
references.pmid: 12566141
references.citation: Herz. 2005 Aug;30(5):368-74; quiz 429-30
references.pmid: 16132239
references.citation: Eur J Clin Nutr. 2005 Oct;59(10):1173-80
references.pmid: 16015255
references.citation: Endocr Relat Cancer. 2007 Sep;14(3):755-67
references.pmid: 17914105
references.citation: Clin Nutr. 2005 Feb;24(1):16-31
references.pmid: 15681098
references.citation: Dig Dis Sci. 2005 Mar;50(3):499-505
references.pmid: 15810632
references.citation: Cancer Epidemiol Biomarkers Prev. 1994 Dec;3(8):687-95
references.pmid: 7881343
references.citation: World J Gastroenterol. 2006 Feb 28;12(8):1261-4
references.pmid: 16534881
references.citation: Lancet Oncol. 2002 Sep;3(9):565-74
references.pmid: 12217794
references.citation: Cancer Epidemiol Biomarkers Prev. 1997 Nov;6(11):863-73
references.pmid: 9367058
references.citation: Prostate Cancer Prostatic Dis. 2005;8(4):316-20
references.pmid: 16158078
references.citation: Cancer Res. 1990 Apr 15;50(8):2341-6
references.pmid: 2317820
references.citation: Cancer Epidemiol Biomarkers Prev. 2003 May;12(5):412-8
references.pmid: 12750235
references.citation: Lancet. 1980 Mar 8;1(8167):523-6
references.pmid: 6102243
references.citation: Arch Intern Med. 2008 Nov 10;168(20):2245-53
references.pmid: 19001202
references.citation: Cancer Causes Control. 2006 Dec;17(10):1245-52
references.pmid: 17111255
references.citation: Int J Cancer. 2008 Oct 15;123(8):1902-6
references.pmid: 18688855
references.citation: Int J Epidemiol. 1998 Oct;27(5):794-8
references.pmid: 9839735
references.citation: J Gastroenterol Hepatol. 2008 Jun;23(6):985-7
references.pmid: 17683487
references.citation: Int J Epidemiol. 1990 Jun;19(2):274-8
references.pmid: 2376436
references.citation: Br J Cancer. 2005 Oct 31;93(9):1062-7
references.pmid: 16234822
references.citation: Cancer. 2006 Jul 1;107(1):28-36
references.pmid: 16721800
references.citation: Cancer Epidemiol Biomarkers Prev. 1996 Aug;5(8):607-12
references.pmid: 8824362
references.citation: Mutat Res. 2008 Jul-Aug;659(1-2):15-30
references.pmid: 18485806
references.citation: Ann Oncol. 2009 Jun;20(6):1113-20
references.pmid: 19164459
references.citation: J Womens Health (Larchmt). 2004 Jan-Feb;13(1):41-53
references.pmid: 15006277
references.citation: Lancet. 1978 May 6;1(8071):978-81
references.pmid: 76902
references.citation: Am J Epidemiol. 2006 Dec 1;164(11):1094-102
references.pmid: 16968859
references.citation: World Health Organ Tech Rep Ser. 2000;894:i-xii, 1-253
references.pmid: 11234459
references.citation: Cancer Causes Control. 2006 Apr;17(3):273-85
references.pmid: 16489535
references.citation: J Natl Cancer Inst. 2002 Jul 3;94(13):981-90
references.pmid: 12096083
references.citation: Am J Clin Nutr. 2003 Nov;78(5):928-34
references.pmid: 14594778
references.citation: Am J Epidemiol. 2006 Oct 15;164(8):769-74
references.pmid: 16952929
references.citation: Am J Clin Nutr. 1983 Feb;37(2):192-3
references.pmid: 6823881
references.citation: Cancer Res. 2008 May 15;68(10):3970-7
references.pmid: 18483283