title: Phosphonate terminated PPH dendrimers: influence of pendant alkyl chains on the in vitro anti-HIV-1 properties.
abstract: The synthesis, characterization and in vitro anti-HIV activity of a series of generation one dendrimers having phosphonate groups with pendant alkyl chains are described. The influence of the lateral alkyl chains on the biological properties was correlated to (1)H-(1)H NOESY experiments.
authors.affiliation: Laboratoire de Chimie de Coordination du CNRS, UPR 8241, 205 route de Narbonne, F-31077, Toulouse, France.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Pérez-Anes
authors.forename: Grégory
authors.initials: G
authors.lastname: Spataro
authors.forename: Yannick
authors.initials: Y
authors.lastname: Coppel
authors.forename: Christiane
authors.initials: C
authors.lastname: Moog
authors.forename: Muriel
authors.initials: M
authors.lastname: Blanzat
authors.forename: Cédric-Olivier
authors.initials: CO
authors.lastname: Turrin
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Caminade
authors.forename: Isabelle
authors.initials: I
authors.lastname: Rico-Lattes
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Majoral
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis / Q000494:pharmacology; D002460:Cell Line; D050091:Dendrimers / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D063065:Organophosphonates / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D019380:Anti-HIV Agents; D050091:Dendrimers; D063065:Organophosphonates