title: Eosinophilic pneumonitis induced by aerosol-administered diesel oil and pyrethrum to mice.
abstract: OBJECTIVE
  To confirm the episode of eosinophilic pneumonitis that occurred in March 2001 in Manaus, Amazon, northern Brazil, as secondary to home aerosolization with 2% cypermethrin diluted in diesel compared with the more conventional 1% cypermethrin and soybean solution used in prophylaxis of dengue.
  
  
  METHODS
  Four groups of Swiss mice were kept in polycarbonate cages aerosolized with one of the following solutions: diesel, diesel and cypermethrin, soy oil and cypermethrin, and saline. Three and 6 days after exposure, resistance and compliance of the respiratory system and white cell kinetics in peripheral blood and lung tissue were analyzed.
  
  
  RESULTS
  The group exposed to diesel and cypermethrin showed higher respiratory system resistance (p < 0.001), lower compliance (p = 0.03), and increased eosinophils in blood (p = 0.03) and lung tissue (p = 0.005) compared with the other groups. There was an increase of neutrophils in the blood of all experimental groups on the third day after exposure (p < 0.001).
  
  
  CONCLUSIONS
  We concluded that diesel associated with cypermethrin induced lung hyperresponsiveness in this experimental model and was associated with increased polymorphonuclear cells (eosinophils and neutrophils) in blood and lungs. This effect is strongest on the third day after exposure. These results are similar to the episode that occurred in Manaus in 2001 and suggest that diesel plus cypermethrin home aerosolization for arbovirosis prophylaxis should be revised.
authors.affiliation: Departamento de Clínica Médica, Universidade de São Paulo, Brazil. gajugu@terra.com.br
authors.forename: Maria Lúcia B
authors.initials: ML
authors.lastname: Garcia
authors.forename: Ubiratan P
authors.initials: UP
authors.lastname: Santos
authors.forename: Adenir
authors.initials: A
authors.lastname: Perini
authors.forename: Milena M P
authors.initials: MM
authors.lastname: Acencio
authors.forename: Fernanda D T Q S
authors.initials: FD
authors.lastname: Lopes
authors.forename: Heloisa M S
authors.initials: HM
authors.lastname: Bueno
authors.forename: Paulo H N
authors.initials: PH
authors.lastname: Saldiva
authors.forename: Milton A
authors.initials: MA
authors.lastname: Martins
mesh_terms: D000336:Aerosols; D000818:Animals; D005742:Gasoline / Q000633:toxicity*; D007306:Insecticides / Q000633:toxicity*; D008297:Male; D051379:Mice; D011657:Pulmonary Eosinophilia / Q000139:chemically induced*; D011722:Pyrethrins / Q000633:toxicity*
chemical_list: D000336:Aerosols; D005742:Gasoline; D007306:Insecticides; D011722:Pyrethrins