title: Approaching the cellular mechanism that supports the intercellular spread of Tobacco mosaic virus.
abstract: Plant viruses spread cell-to-cell in infected plants by exploiting plasmodesmata (PD), gatable channels in the cell wall that provide cytoplasmic passageways for the trafficking of informational macromolecules. Since it became known that the intercellular spread of Tobacco mosaic virus (TMV) depends on virus-encoded movement protein (MP), the mechanism by which this protein mediates in the targeting of this virus to PD is subject to intense studies. TMV movement occurs in a non-encapsidated form and thus promises to reveal important host functions involved in the intra-and intercellular trafficking of RNA molecules. We have recently presented new evidence that the cell-to-cell trafficking of TMV RNA (vRNA) involves the formation and intracellular trafficking of distinct MP particles. Upon assembly, these particles detach from cortical microtubule (MT) sites and then move with the flow of ER through the cell. During passage the particles continue to undergo transient interactions with MT which may guide the particles to their destination. The comprehensive analysis of particle composition may lead to important insights into the regulation of RNA transport in plants and may also reveal potential similarities to RNA transport mechanisms in animals and humans.
authors.affiliation: Institut de Biologie Moléculaire des Plantes, Laboratoire propre du CNRS (UPR 2357) conventionné avec l'Université Louis Pasteur (Strasbourg 1), Strasbourg, France.
authors.forename: Adrian
authors.initials: A
authors.lastname: Sambade
authors.forename: Manfred
authors.initials: M
authors.lastname: Heinlein
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