Evidence of increased oxidative stress and a change in the plasminogen activator inhibitor (PAI)-1 to PAI-2 ratio in early-onset but not late-onset preeclampsia.
OBJECTIVE
The aims of this study were to measure the degree of oxidative stress and alterations in plasminogen activator inhibitor (PAI) type 1 and PAI-2 ratio in women with early-onset and late-onset preeclampsia.


METHODS
A case-control study was conducted in women with early-onset (24-32 weeks' gestation; n=18) and late-onset (35-42 weeks' gestation; n=20) preeclampsia and in control pregnant women at corresponding gestational weeks. Placenta, urine, and serum samples were collected.


RESULTS
In early-onset preeclampsia, the median placental concentration of 8-iso-prostaglandin (PG)-F2alpha was higher and the PAI-1 to PAI-2 ratio higher than in early controls. These values did not differ between women with late-onset preeclampsia and their corresponding controls. Serum concentrations of 8-iso-PGF2alpha and vitamins C and E did not differ between cases and controls.


CONCLUSIONS
Early-onset but not late-onset preeclampsia is associated with increased placental oxidative stress and increased PAI-1 to PAI-2 ratio.
Wikström
Anna-Karin
AK
Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden. anna-karin.wikstrom@kbh.uu.se
Nash
Peppi
P
Eriksson
Ulf J
UJ
Olovsson
Matts H
MH
D000328:Adult; D001205:Ascorbic Acid / Q000032:analysis; D016022:Case-Control Studies; D015237:Dinoprost / Q000031:analogs & derivatives / Q000032:analysis; D005260:Female; D006801:Humans; D018384:Oxidative Stress; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood*; D017396:Plasminogen Activator Inhibitor 2 / Q000097:blood*; D011225:Pre-Eclampsia / Q000503:physiopathology*; D011247:Pregnancy; D014810:Vitamin E / Q000032:analysis
D017395:Plasminogen Activator Inhibitor 1; D017396:Plasminogen Activator Inhibitor 2; D014810:Vitamin E; C075750:8-epi-prostaglandin F2alpha; D015237:Dinoprost; D001205:Ascorbic Acid