Taking the chemical out of chemical genetics.
Screening a library of expressed cyclic peptides identified clones that reverse the cytotoxicity of alpha-synuclein in yeast and Caenorhabditis elegans. The results suggest a new approach for intervention in Parkinson's disease, and perhaps a druggable target.
Scott
Charles P
CP
Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA. cscott@mail.jci.tju.edu.
D000818:Animals; D017173:Caenorhabditis elegans / Q000187:drug effects / Q000235:genetics; D015195:Drug Design; D006801:Humans; D016296:Mutagenesis; D010300:Parkinson Disease / Q000235:genetics / Q000378:metabolism; D019151:Peptide Library; D010456:Peptides, Cyclic / Q000737:chemistry* / Q000235:genetics*; D015003:Yeasts / Q000187:drug effects / Q000235:genetics; D051844:alpha-Synuclein / Q000235:genetics / Q000502:physiology
D019151:Peptide Library; D010456:Peptides, Cyclic; D051844:alpha-Synuclein
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