title: Rituximab in the treatment of non-Hodgkin's lymphoma.
abstract: Besides traditional cytostatic drugs the introduction of monoclonal antibodies has substantially influenced current treatment concepts of non-Hodgkin's lymphoma (NHL). Rituximab, a monoclonal anti-CD20 chimeric antibody, now has been widely evaluated in the various B-cell lymphatic neoplasms. Large phase III studies helped to prove the value of this drug in follicular lymphoma as part of induction or relapse treatment as well as maintenance treatment. The addition of rituximab to the well established CHOP regimens has increased achievable cure rates in diffuse large cell lymphoma, and this combination is now accepted worldwide as standard of care. Although conflicting results are available, rituximab is widely used for the treatment of mantle cell lymphoma. For the less frequent lymphoma entities phase 2 studies show a considerable efficiency for most of these B-NHL variants. Current research focuses on combined chemoimmunotherapy approaches, optimization of dosing regimens, and combination with novel agents.
authors.affiliation: Hematology/Oncology, Johannes Gutenberg-University, Mainz, Germany.
authors.forename: Beate
authors.initials: B
authors.lastname: Hauptrock
authors.forename: Georg
authors.initials: G
authors.lastname: Hess
references.citation: Blood. 2005 Dec 1;106(12):3725-32
references.pmid: 16123223
references.citation: Clin Cancer Res. 2004 Dec 15;10(24):8620-9
references.pmid: 15623646
references.citation: Blood. 1994 Sep 1;84(5):1361-92
references.pmid: 8068936
references.citation: Blood. 2007 Jan 15;109(2):405-11
references.pmid: 17008537
references.citation: Nat Med. 2000 Apr;6(4):443-6
references.pmid: 10742152
references.citation: Nature. 1975 Aug 7;256(5517):495-7
references.pmid: 1172191
references.citation: Ann Oncol. 2005 Jan;16(1):132-8
references.pmid: 15598950
references.citation: Blood. 1998 Sep 15;92(6):1927-32
references.pmid: 9731049
references.citation: Blood. 1994 Oct 15;84(8):2457-66
references.pmid: 7522629
references.citation: J Clin Oncol. 2003 Aug 15;21(16):3051-9
references.pmid: 12837807
references.citation: Jpn J Clin Oncol. 2008 May;38(5):373-80
references.pmid: 18413337
references.citation: Semin Oncol. 2003 Apr;30(2):110-5
references.pmid: 12720118
references.citation: Lancet. 1991 Nov 9;338(8776):1175-6
references.pmid: 1682595
references.citation: Leuk Res. 2005 Jan;29(1):107-8
references.pmid: 15541482
references.citation: J Clin Oncol. 2005 Oct 1;23(28):7013-23
references.pmid: 16145068
references.citation: J Clin Oncol. 2007 Apr 10;25(11):1350-6
references.pmid: 17312328
references.citation: Blood. 2006 Nov 15;108(10):3295-301
references.pmid: 16873669
references.citation: Blood. 1996 Mar 1;87(5):1972-6
references.pmid: 8634446
references.citation: J Clin Oncol. 2004 Dec 1;22(23):4711-6
references.pmid: 15483015
references.citation: Leukemia. 1995 Jul;9(7):1116-20
references.pmid: 7630181
references.citation: N Engl J Med. 1987 Apr 2;316(14):825-30
references.pmid: 2434850
references.citation: Eur J Haematol. 2004 Oct;73(4):258-62
references.pmid: 15347312
references.citation: J Clin Oncol. 2001 Apr 15;19(8):2153-64
references.pmid: 11304767
references.citation: J Clin Oncol. 1995 Apr;13(4):974-82
references.pmid: 7707126
references.citation: Hematol J. 2004;5(6):467-71
references.pmid: 15570286
references.citation: J Immunother. 2001 May-Jun;24(3):272-9
references.pmid: 11394506
references.citation: Ann Hematol. 2007 Aug;86(8):599-607
references.pmid: 17522862
references.citation: J Clin Oncol. 2008 Jul 1;26(19):3166-75
references.pmid: 18490650
references.citation: J Clin Oncol. 2004 Nov 15;22(22):4561-6
references.pmid: 15542807
references.citation: Cancer Res. 1980 Sep;40(9):3147-54
references.pmid: 7427932
references.citation: J Clin Oncol. 2000 Sep;18(17):3135-43
references.pmid: 10963642
references.citation: Blood. 2006 Dec 15;108(13):4003-8
references.pmid: 16946304
references.citation: J Clin Oncol. 2002 May 1;20(9):2327-33
references.pmid: 11981004
references.citation: J Clin Oncol. 2005 Jul 1;23(19):4390-8
references.pmid: 15994148
references.citation: J Clin Oncol. 2007 Oct 20;25(30):4730-5
references.pmid: 17947720
references.citation: J Immunol. 2000 Nov 15;165(10):5954-61
references.pmid: 11067958
references.citation: J Clin Oncol. 2005 Feb 1;23(4):705-11
references.pmid: 15598978
references.citation: Hematol Oncol. 2007 Sep;25(3):127-31
references.pmid: 17514771
references.citation: World J Gastroenterol. 2007 Jul 14;13(26):3554-66
references.pmid: 17659705
references.citation: Oncogene. 2003 Oct 20;22(47):7359-68
references.pmid: 14576843
references.citation: Blood. 2003 Jun 1;101(11):4279-84
references.pmid: 12576316
references.citation: Clin Cancer Res. 2005 Oct 1;11(19 Pt 2):7151s-7157s
references.pmid: 16203815
references.citation: J Clin Oncol. 2005 May 20;23(15):3383-9
references.pmid: 15908650
references.citation: Clin Cancer Res. 2006 Jan 1;12(1):242-9
references.pmid: 16397048
references.citation: Blood. 2002 Feb 1;99(3):754-8
references.pmid: 11806974
references.citation: Leuk Lymphoma. 2004 Oct;45(10):2047-55
references.pmid: 15370249
references.citation: J Clin Oncol. 2005 Feb 20;23(6):1088-95
references.pmid: 15657401
references.citation: Haematologica. 2004 Jun;89(6):753-4
references.pmid: 15194546
references.citation: J Clin Oncol. 2005 Sep 10;23(26):6387-93
references.pmid: 16155024
references.citation: Clin Cancer Res. 2001 Aug;7(8):2195-204
references.pmid: 11489792
references.citation: Semin Oncol. 1987 Jun;14(2 Suppl 2):13-7
references.pmid: 3589701
references.citation: Blood. 2004 Mar 15;103(6):2332-6
references.pmid: 14630803
references.citation: J Clin Oncol. 2008 Jun 1;26(16):2725-31
references.pmid: 18427151
references.citation: Bone Marrow Transplant. 2002 May;29(9):769-75
references.pmid: 12040475
references.citation: Am J Hematol. 1999 Dec;62(4):247-50
references.pmid: 10589082
references.citation: J Clin Oncol. 2004 Jul 1;22(13):2654-61
references.pmid: 15159414
references.citation: Curr Opin Oncol. 2007 Sep;19(5):458-63
references.pmid: 17762571
references.citation: Blood. 2003 Aug 1;102(3):810-3
references.pmid: 12663446
references.citation: Ann Hematol. 2006 Nov;85(11):769-79
references.pmid: 16896912
references.citation: J Clin Oncol. 2008 Jun 1;26(16):2607-9
references.pmid: 18509168
references.citation: J Clin Oncol. 2006 Jul 1;24(19):3121-7
references.pmid: 16754935
references.citation: Blood. 2002 Aug 1;100(3):1104-5
references.pmid: 12150156
references.citation: Eur J Haematol. 2007 Aug;79(2):107-13
references.pmid: 17635235
references.citation: Semin Oncol. 2000 Dec;27(6 Suppl 12):17-24
references.pmid: 11225995
references.citation: Blood. 2003 Oct 15;102(8):2741-5
references.pmid: 12842999
references.citation: Leuk Lymphoma. 1994;14 Suppl 1:67-71
references.pmid: 7820056
references.citation: Leukemia. 2009 Jan;23(1):153-61
references.pmid: 18818699
references.citation: N Engl J Med. 2002 Jan 24;346(4):235-42
references.pmid: 11807147
references.citation: J Clin Oncol. 2003 May 1;21(9):1746-51
references.pmid: 12721250
references.citation: Leukemia. 2007 Apr;21(4):835-6
references.pmid: 17268523
references.citation: N Engl J Med. 1990 Apr 19;322(16):1117-21
references.pmid: 1969613
references.citation: Blood. 2000 Aug 1;96(3):864-9
references.pmid: 10910898
references.citation: J Clin Oncol. 2007 Aug 1;25(22):3344-9
references.pmid: 17577016
references.citation: Blood. 1992 Sep 15;80(6):1502-10
references.pmid: 1520877
references.citation: Clin Lymphoma. 2002 Jun;3(1):41-7
references.pmid: 12141954
references.citation: Br J Haematol. 2007 Mar;136(5):685-98
references.pmid: 17229246
references.citation: Lancet Oncol. 2006 May;7(5):379-91
references.pmid: 16648042
references.citation: N Engl J Med. 1995 Dec 7;333(23):1540-5
references.pmid: 7477169
references.citation: Ann Hematol. 2007 Feb;86(2):107-15
references.pmid: 17103169
references.citation: J Clin Oncol. 2005 Mar 20;23(9):1979-83
references.pmid: 15668468
references.citation: Blood. 2003 Aug 1;102(3):1070-1
references.pmid: 12702507
references.citation: Am J Hematol. 2006 Apr;81(4):302
references.pmid: 16550511
references.citation: Blood. 2005 Feb 15;105(4):1417-23
references.pmid: 15494430
references.citation: J Clin Oncol. 2005 Jun 20;23(18):4070-8
references.pmid: 15767647
references.citation: J Clin Oncol. 2001 Jan 15;19(2):389-97
references.pmid: 11208830
references.citation: Br J Dermatol. 2006 Nov;155(5):1053-6
references.pmid: 17034541
references.citation: Blood. 1998 Nov 1;92(9):3137-47
references.pmid: 9787149
references.citation: Blood. 2006 Apr 15;107(8):3053-7
references.pmid: 16254143
references.citation: Haematologica. 2007 Jan;92(1):42-9
references.pmid: 17229634
references.citation: Blood. 2001 Jan 1;97(1):101-6
references.pmid: 11133748
references.citation: Blood. 2002 Feb 15;99(4):1486-8
references.pmid: 11830505
references.citation: J Clin Oncol. 2005 Jun 20;23(18):4079-88
references.pmid: 15767648
references.citation: Leukemia. 2008 May;22(5):1082-3
references.pmid: 17972949
references.citation: J Clin Oncol. 2007 May 20;25(15):1986-92
references.pmid: 17420513
references.citation: Neurology. 2004 Sep 14;63(5):901-3
references.pmid: 15365145
references.citation: Cancer. 2006 Apr 1;106(7):1569-80
references.pmid: 16502413
references.citation: Blood. 2001 Sep 1;98(5):1326-31
references.pmid: 11520778
references.citation: Blood. 2000 Feb 1;95(3):1056-65
references.pmid: 10648422
references.citation: Clin Cancer Res. 2004 Aug 15;10(16):5327-34
references.pmid: 15328168
references.citation: J Clin Oncol. 2006 Sep 1;24(25):4123-8
references.pmid: 16896005
references.citation: Semin Oncol. 1999 Oct;26(5 Suppl 14):88-96
references.pmid: 10561023
references.citation: J Clin Oncol. 1998 Aug;16(8):2825-33
references.pmid: 9704735
references.citation: Blood. 1987 Feb;69(2):584-91
references.pmid: 3492224
references.citation: J Immunother. 2002 Jan-Feb;25(1):72-81
references.pmid: 11924912
references.citation: Blood. 2008 Aug 15;112(4):975-80
references.pmid: 18411418
references.citation: Clin Lab Haematol. 2006 Jun;28(3):211-4
references.pmid: 16706940
references.citation: J Clin Oncol. 2005 Mar 20;23(9):1984-92
references.pmid: 15668467
references.citation: Lancet Oncol. 2008 Feb;9(2):105-16
references.pmid: 18226581
references.citation: Br J Haematol. 1999 Aug;106(2):545-52
references.pmid: 10460621
references.citation: Expert Opin Drug Saf. 2005 May;4(3):599-608
references.pmid: 15934864
references.citation: Lancet Oncol. 2008 May;9(5):435-44
references.pmid: 18400558
references.citation: J Clin Oncol. 2001 Apr 15;19(8):2165-70
references.pmid: 11304768
references.citation: Haematologica. 2006 May;91(5):715-6
references.pmid: 16670080
references.citation: J Clin Oncol. 2003 Jun 15;21(12):2407-14
references.pmid: 12805341
references.citation: Blood. 2004 May 15;103(10):3684-8
references.pmid: 14739217
references.citation: Blood. 2006 Jun 15;107(12):4658-62
references.pmid: 16497968
references.citation: Blood. 2003 Aug 1;102(3):996-9
references.pmid: 12714514
references.citation: Blood. 2003 Dec 1;102(12):3906-11
references.pmid: 12816862
references.citation: Lancet Oncol. 2003 Feb;4(2):95-103
references.pmid: 12573351
references.citation: Blood. 2005 Sep 1;106(5):1538-43
references.pmid: 15914552
references.citation: Haematologica. 2001 Oct;86(10):1046-50
references.pmid: 11602410
references.citation: Blood. 2004 Nov 15;104(10):3064-71
references.pmid: 15284112
references.citation: Ann Hematol. 1998 Jul-Aug;77(1-2):89-91
references.pmid: 9760161
references.citation: Blood. 2004 Jun 15;103(12):4416-23
references.pmid: 14976046