title: Differential-absorption photoacoustic imaging.
abstract: We present differential-absorption photoacoustic imaging, which detects the difference between transient and ground-state absorption, for contrast enhancement based on suppressing undesired objects. Two tubes were imaged. One contains a Pt(II) octaethylporphine (PtOEP) dye solution and serves as an object of interest, while the other contains an IR-783 (from Sigma-Aldrich) dye solution and serves as an object to suppress. Although the IR-783 tube dominates the conventional photoacoustic image, it is suppressed by 43 dB and consequently significantly overwhelmed by the PtOEP tube in the differential-absorption photoacoustic image. Imaging depth in this mode is also discussed.
authors.affiliation: Department of Bioengineering, University of Washington, 1705 NE Pacific Street, Seattle, Washington 98195, USA. shengwen@u.washington.edu
authors.forename: Sheng-Wen
authors.initials: SW
authors.lastname: Huang
authors.forename: Janet F
authors.initials: JF
authors.lastname: Eary
authors.forename: Congxian
authors.initials: C
authors.lastname: Jia
authors.forename: Lingyun
authors.initials: L
authors.lastname: Huang
authors.forename: Shai
authors.initials: S
authors.lastname: Ashkenazi
authors.forename: Matthew
authors.initials: M
authors.lastname: O'Donnell
mesh_terms: D000042:Absorption; D000162:Acoustics; D004396:Coloring Agents; D008027:Light; D057054:Molecular Imaging / Q000379:methods*; D009942:Organometallic Compounds
chemical_list: D004396:Coloring Agents; D009942:Organometallic Compounds