title: Case of follicular mucinosis: nestin-expression in mucin-producing cells.
abstract: A 29-year-old Japanese man had an asymptomatic, solitary, indurated, erythematous plaque measuring 30 mm x 30 mm on his jaw that had been present for a month. The skin lesion had follicular hyperkeratosis, and lacked hair. A skin biopsy specimen showed a dense perifollicular infiltration composed of lymphocytes, with an admixture of eosinophils in the full thickness of the dermis. The hair follicles and sebaceous glands had reticular epithelial degeneration by mucoid material of the outer root sheath and sebaceous epithelium. The mucoid material stained with Alcian blue at pH 2.5. The clinical and histological features were consistent with the diagnosis of follicular mucinosis. On immunohistochemistry, the outer root sheath cells with reticular epithelial degeneration were nestin-positive and keratin 15-negative. These results suggest that the outer root sheath cells with reticular epithelial degeneration come from the nestin-positive, multipotent, hair follicle stem cells.
authors.affiliation: Department of Dermatology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan. sakuma_93@yahoo.co.jp
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Sakuma
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Amoh
authors.forename: Shiro
authors.initials: S
authors.lastname: Niiyama
authors.forename: Maho
authors.initials: M
authors.lastname: Kanoh
authors.forename: Kensei
authors.initials: K
authors.lastname: Katsuoka
mesh_terms: D000328:Adult; D018859:Hair Follicle / Q000378:metabolism*; D006801:Humans; D007381:Intermediate Filament Proteins / Q000378:metabolism*; D008297:Male; D000507:Mucinosis, Follicular / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D064231:Nestin
chemical_list: D007381:Intermediate Filament Proteins; C577484:NES protein, human; D009419:Nerve Tissue Proteins; D064231:Nestin