Stem cell donation--what advice can be given to the donor?
Haematopoietic stem cell transplantation (HSCT) is widely used to treat patients with a range of haematological and non-haematological disorders. Both bone marrow and peripheral blood stem cell collection are associated with morbidity and, very rarely, mortality. We investigated the information that exists to adequately inform donors about the relative merits of each procedure. We carried out a systematic review analysing data from six prospective randomised controlled trials of related donors and discuss here the merits and drawbacks of this approach. Registry data mostly describes patient outcome but stem cell donor registries collect and report information on unrelated donors which could easily be extended to related donors. Further well-designed, randomised studies are required.
Pamphilon
Derwood
D
NHS Blood and Transplant Bristol Centre, Bristol, UK. derwood.pamphilon@nhsbt.nhs.uk
Siddiq
Samreen
S
Brunskill
Susan
S
Dorée
Carolyn
C
Hyde
Chris
C
Horowitz
Mary
M
Stanworth
Simon
S
D046148:Donor Selection / Q000592:standards; D019317:Evidence-Based Medicine / Q000379:methods; D006266:Health Education / Q000379:methods*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D016032:Randomized Controlled Trials as Topic / Q000379:methods; D012042:Registries; D014019:Tissue Donors / Q000523:psychology*; D020858:Tissue and Organ Harvesting / Q000009:adverse effects* / Q000379:methods
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