title: Oxidative stress and hypoxia contribute to Alzheimer's disease pathogenesis: two sides of the same coin.
abstract: While it is well established that stroke and cerebral hypoperfusion are risk factors for Alzheimer's disease (AD), the molecular link between ischemia/hypoxia and amyloid precursor protein (APP) processing has only been recently established. Here we review the role of the release of reactive oxygen species (ROS) by the mitochondrial electron chain in response to hypoxia, providing evidence that hypoxia fosters the amyloidogenic APP processing through a biphasic mechanism that up-regulates Beta-secretase activity, which involves an early release of ROS and an activation of HIF-1Alpha.
authors.affiliation: Department of Experimental Medicine and Oncology, University of Torino, Italy. elena.tamagno@unito.it
authors.forename: Michela
authors.initials: M
authors.lastname: Guglielmotto
authors.forename: Elena
authors.initials: E
authors.lastname: Tamagno
authors.forename: Oliviero
authors.initials: O
authors.lastname: Danni
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology*; D053829:Amyloid Precursor Protein Secretases / Q000096:biosynthesis; D016282:Aspartic Acid Endopeptidases / Q000096:biosynthesis; D004579:Electron Transport; D004790:Enzyme Induction; D006801:Humans; D000860:Hypoxia / Q000378:metabolism / Q000473:pathology*; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D017382:Reactive Oxygen Species; D053829:Amyloid Precursor Protein Secretases; D016282:Aspartic Acid Endopeptidases; C509280:BACE1 protein, human