Functional response to inhaled salbutamol and/or ipratropium bromide in Ascaris suum-sensitised cats with allergen-induced bronchospasms.
Knowledge about the use of inhaled bronchodilators in cats with so-called 'feline asthma' is limited and relies on the experience of clinicians treating these patients. A randomised controlled four-way crossover study was therefore designed to compare the effects of salbutamol (SAL, 100 μg), ipratropium bromide (IB, 20 μg) and a combination of both (SAL/IB, 100 μg/20 μg), delivered through a pressurised metered-dose inhaler (pMDI) connected to a spacing chamber, on allergen-induced bronchospasms in five Ascaris suum (AS)-sensitised cats. Four AS bronchial provocation challenges were carried out at 1 week intervals, followed by one of four treatment protocols: SAL, IB, SAL/IB or control (untreated). Enhanced pause (Penh), an estimator of airflow limitation measured by barometric whole-body plethysmography, was repeatedly assessed within 120 min following the administration of each treatment protocol. Responses to inhaled medications were evaluated by calculating the area under the time-response curves (AUC) from 0 to 60 or 120 min after drug administration (AUC(0-60), AUC(0-120)), as well as the times required for half-recovery (T(50%)) or for returning to nearly basal conditions (T(20%)). No significant differences were found among the four study groups, with reference to the mean AUC(0-60), T(20%) and T(50%) values of Penh (P>0.05). Mean AUC(0-120) values of Penh were similar between the bronchodilators tested, but were significantly lower than those in the untreated group. It was concluded that inhalation of SAL, IB and SAL/IB via pMDI failed to improve most Penh-derived parameters, which suggested that these bronchodilators were of limited efficacy in reversing allergen-induced bronchospasm in cats. However, further studies using a larger number of animals are warranted to investigate if different drugs or delivery devices or higher dosages may be more effective.
Leemans
Jérôme
J
Section of Pharmacology, Pharmacotherapy and Toxicology, Department for Functional Sciences B41, Faculty of Veterinary Medicine, University of Liège, 4000 Liège, Belgium. J.Leemans@student.ulg.ac.be
Kirschvink
Nathalie
N
Clercx
Cécile
C
Cambier
Carole
C
Gustin
Pascal
P
D000280:Administration, Inhalation; D000420:Albuterol / Q000627:therapeutic use*; D000485:Allergens / Q000009:adverse effects; D000818:Animals; D017165:Ascaris suum / Q000276:immunology; D001986:Bronchial Spasm / Q000188:drug therapy / Q000209:etiology / Q000662:veterinary*; D001993:Bronchodilator Agents / Q000627:therapeutic use*; D002371:Cat Diseases / Q000188:drug therapy* / Q000276:immunology; D002415:Cats; D018592:Cross-Over Studies; D004359:Drug Therapy, Combination / Q000662:veterinary; D005260:Female; D009241:Ipratropium / Q000627:therapeutic use*; D008297:Male; D016896:Treatment Outcome
D000485:Allergens; D001993:Bronchodilator Agents; D009241:Ipratropium; D000420:Albuterol