title: Substrate specificity of N-acetylhexosamine kinase towards N-acetylgalactosamine derivatives.
abstract: We report herein a bacterial N-acetylhexosamine kinase, NahK, with broad substrate specificity towards structurally modified GalNAc analogues, and the production of a GalNAc-1-phosphate library using this kinase.
authors.affiliation: Departments of Chemistry and Biochemistry, The Ohio State University, 484 w. 12th Ave. Columbus, OH 43210, USA.
authors.forename: Li
authors.initials: L
authors.lastname: Cai
authors.forename: Wanyi
authors.initials: W
authors.lastname: Guan
authors.forename: Wenjun
authors.initials: W
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Zhao
authors.forename: Motomitsu
authors.initials: M
authors.lastname: Kitaoka
authors.forename: Jie
authors.initials: J
authors.lastname: Shen
authors.forename: Crystal
authors.initials: C
authors.lastname: O'Neil
authors.forename: Peng George
authors.initials: PG
authors.lastname: Wang
mesh_terms: D000116:Acetylgalactosamine / Q000031:analogs & derivatives* / Q000378:metabolism*; D001644:Bifidobacterium / Q000201:enzymology*; D010770:Phosphotransferases / Q000378:metabolism*; D054852:Small Molecule Libraries / Q000737:chemistry / Q000378:metabolism; D013379:Substrate Specificity
chemical_list: D054852:Small Molecule Libraries; D010770:Phosphotransferases; D000116:Acetylgalactosamine