title: Abnormal medial temporal activity for bound information during working memory maintenance in patients with schizophrenia.
abstract: Alterations of binding in long-term memory in schizophrenia are well established and occur as a result of aberrant activity in the medial temporal lobe (MTL). In working memory (WM), such a deficit is less clear and the pathophysiological bases remain unstudied. Seventeen patients with schizophrenia and 17 matched healthy controls performed a WM binding task while undergoing functional magnetic resonance imaging. Binding was assessed by contrasting two conditions comprising an equal amount of verbal and spatial information (i.e., three letters and three spatial locations), but differing in the absence or presence of a link between them. In healthy controls, MTL activation was observed for encoding and maintenance of bound information but not for its retrieval. Between-group comparisons revealed that patients with schizophrenia showed MTL hypoactivation during the maintenance phase only. In addition, BOLD signals correlated with behavioral performance in controls but not in patients with schizophrenia. Our results confirm the major role that the MTL plays in the pathophysiology of schizophrenia. Short-term and long-term relational memory deficits in schizophrenia may share common cognitive and functional pathological bases. Our results provide additional information about the episodic buffer that represents an integrative interface between WM and long-term memory.
authors.affiliation: Physiopathologie Clinique et Expérimentale de la Schizophrénie, INSERM U666, Strasbourg, France. david.luck@mail.mcgill.ca
authors.forename: David
authors.initials: D
authors.lastname: Luck
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Danion
authors.forename: Corrine
authors.initials: C
authors.lastname: Marrer
authors.forename: Bich-Tuy
authors.initials: BT
authors.lastname: Pham
authors.forename: Daniel
authors.initials: D
authors.lastname: Gounot
authors.forename: Jack
authors.initials: J
authors.lastname: Foucher
mesh_terms: D000328:Adult; D001931:Brain Mapping; D016022:Case-Control Studies; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008569:Memory Disorders / Q000209:etiology* / Q000473:pathology*; D008570:Memory, Short-Term / Q000502:physiology*; D009483:Neuropsychological Tests; D010100:Oxygen / Q000097:blood; D010775:Photic Stimulation / Q000379:methods; D011597:Psychomotor Performance / Q000502:physiology; D012153:Retention, Psychology / Q000502:physiology*; D012559:Schizophrenia / Q000150:complications* / Q000473:pathology; D013702:Temporal Lobe / Q000098:blood supply / Q000473:pathology*; D055815:Young Adult
chemical_list: D010100:Oxygen