title: Variations in Hedgehog signaling: divergence and perpetuation in Sufu regulation of Gli.
abstract: The Hedgehog (Hh) proteins play a universal role in metazoan development. Nevertheless, fundamental differences exist between Drosophila and vertebrates in the transduction of the Hh signal, notably regarding the role of primary cilia in mammalian cells. In this issue of Genes & Development, Chen and colleagues (pp. 1910-1928) demonstrate that mouse Suppressor of fused (Sufu) regulates the stability of the transcription factors Gli2 and Gli3 by antagonizing the conserved Gli degradation device mediated by Hib/Spop in a cilia-independent manner.
authors.affiliation: Institut Biologie du Développement et Cancer-IBDC, Université de Nice-Sophia Antipolis, CNRS UMR 6543, Centre de Biochimie, Nice Cedex 02, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Ruel
authors.forename: Pascal P
authors.initials: PP
authors.lastname: Thérond
mesh_terms: D000818:Animals; D002923:Cilia / Q000502:physiology; D019143:Evolution, Molecular; D005786:Gene Expression Regulation; D053823:Hedgehog Proteins / Q000502:physiology*; D051741:Kruppel-Like Transcription Factors / Q000378:metabolism*; D051379:Mice; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009687:Nuclear Proteins / Q000378:metabolism; D055550:Protein Stability; D012097:Repressor Proteins / Q000378:metabolism*; D015398:Signal Transduction; D043743:Ubiquitin-Protein Ligase Complexes; D000075746:Zinc Finger Protein Gli2; D000074290:Zinc Finger Protein Gli3
chemical_list: C000618551:Gli2 protein, mouse; C465571:Gli3 protein, mouse; D053823:Hedgehog Proteins; D051741:Kruppel-Like Transcription Factors; D009419:Nerve Tissue Proteins; D009687:Nuclear Proteins; D012097:Repressor Proteins; C490763:Sufu protein, mouse; D000075746:Zinc Finger Protein Gli2; D000074290:Zinc Finger Protein Gli3; C509762:Spop protein, mouse; D043743:Ubiquitin-Protein Ligase Complexes
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