title: Early cardiovascular autonomic dysfunction, beta cell function and insulin resistance in obese adolescents.
abstract: OBJECTIVE
  The aim of this study was to assess the metabolic and cardiovascular autonomic phenotype in adolescent obesity.
  
  
  METHODS
  Eighteen non diabetic obese individuals and ten lean age-matched control adolescents were included in the study. All subjects underwent Oral Glucose Tolerance Test (OGTT) with insulin and glucose determination for the calculation of AUC, OGIS, QUICKI, and disposition index. Cardiovascular assessments included 24-hour Holter ECG for HRV measurements, ABP monitoring and echocardiography.
  
  
  RESULTS
  Obese adolescents had higher serum lipids, reduced insulin sensitivity and higher insulin resistance. Obese individuals showed indeed a normal beta-cell function, with insulin AUC and disposition index similar to controls. However, obese adolescents presented a progressive reduction ofvagal indexes (RMSSD, HF) and an increase in sympathetic indexes (LF, LF/HF), which correlated with OGIS and beta-cell function parameters.
  
  
  CONCLUSIONS
  Adolescent obesity is characterized by insulin resistance with normal beta-cell function. Metabolic modifications may lead to an early impairment of the autonomic pattern.
authors.affiliation: Department of Pediatrics, University of Torino, Torino, Italy. ivana.rabbone@unito.it
authors.forename: Ivana
authors.initials: I
authors.lastname: Rabbone
authors.forename: Adriana
authors.initials: A
authors.lastname: Bobbio
authors.forename: Franco
authors.initials: F
authors.lastname: Rabbia
authors.forename: Maria Cristina
authors.initials: MC
authors.lastname: Bertello
authors.forename: Maria Giovanna
authors.initials: MG
authors.lastname: Ignaccoldo
authors.forename: Elisa
authors.initials: E
authors.lastname: Saglio
authors.forename: Fulvio
authors.initials: F
authors.lastname: Morello
authors.forename: Franco
authors.initials: F
authors.lastname: Veglio
authors.forename: Giovanni
authors.initials: G
authors.lastname: Pacini
authors.forename: Franco
authors.initials: F
authors.lastname: Cerutti
mesh_terms: D000293:Adolescent; D001342:Autonomic Nervous System Diseases / Q000453:epidemiology*; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000502:physiology; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000453:epidemiology*; D016022:Case-Control Studies; D002648:Child; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology*; D050417:Insulin-Secreting Cells / Q000502:physiology*; D009765:Obesity / Q000097:blood* / Q000150:complications / Q000503:physiopathology*; D012307:Risk Factors
chemical_list: D001786:Blood Glucose; D007328:Insulin