Resveratrol and its antifungal activity against Candida species.
Resveratrol is a natural stilbene synthesised by plants. This compound has been shown to inhibit the growth of Candida albicans TIMM 1768 efficiently. Till date, no information is available for other Candida species. The evaluation of the antimicrobial activity of resveratrol was analysed by the inhibition of the growth and metabolism assays. Our data indicate that resveratrol is not effective against Candida albicans and non-C. albicans species (C. dubliniensis, C. glabrata, C. tropicalis, C. parapsilosis and C. krusei) in vitro. The potential candidacidal activity could not be confirmed.
Weber
K
K
Department of Oncology and Haematology, Charité- Universitätsmedizin Berlin, CCM, Charitéplatz, Berlin. kai.weber@charite.de
Schulz
B
B
Ruhnke
M
M
D000935:Antifungal Agents / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects* / Q000254:growth & development; D002177:Candidiasis / Q000382:microbiology; D006801:Humans; D008826:Microbial Sensitivity Tests; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*
D000935:Antifungal Agents; D013267:Stilbenes; D000077185:Resveratrol