title: Parasitological and clinical responses of lambs experimentally infected with Haemonchus contortus (L3) with and without ivermectin treatment.
abstract: Haemonchus contortus is one of the most important parasites that infects sheep and exerts its pathogenic effects by sucking blood, causing disturbances of organ-functions and thus inducing alterations in various normal physiological parameters. Changes in live body weight, faecal egg count, kinetics of circulating eosinophils and PCV value were studied at weekly interval for a period of 84 days in 18 lambs of local breed after infection with a single dose of 5000 H. contortus (L(3)). In the two groups of lambs infected with nematodes both non-treated and treated with ivermectin (HcNT and HcIT), similar egg excretion patterns was observed starting from third week after infection, with a regular increase in FEC. Examination of whole abomasum of each animal revealed no developmental stage of nematode from treated and control lambs on day 84. The total mean number of H. contortus worms recovered at necropsy from abomasa of untreated infected lambs (group HcNT) was 2576.2 (+/-221.0). The significant loss of body weight, development of heavy worm burden and severe anaemia as indicated by reduced PCV in untreated infected lambs indicated high susceptibility of the lambs to H. contortus. On the other hand, complete absence of the parasite, improved PCV value and body weight after treatment of infected animals (HcIT) proved 100% efficacy of ivermectin against H. contortus.
authors.affiliation: Department of Pathology and Parasitology, Faculty of Veterinary Medicine, Addis Ababa University, PO Box 34, Debre Zeit, Ethiopia.
authors.forename: H T
authors.initials: HT
authors.lastname: Yacob
authors.forename: Ch
authors.initials: Ch
authors.lastname: Mistre
authors.forename: A H
authors.initials: AH
authors.lastname: Adem
authors.forename: A K
authors.initials: AK
authors.lastname: Basu
mesh_terms: D000818:Animals; D000977:Antiparasitic Agents / Q000627:therapeutic use*; D001835:Body Weight / Q000502:physiology; D004804:Eosinophils / Q000502:physiology; D005243:Feces / Q000469:parasitology; D005260:Female; D006188:Haemonchiasis / Q000188:drug therapy / Q000469:parasitology / Q000503:physiopathology / Q000662:veterinary*; D006189:Haemonchus; D006400:Hematocrit / Q000662:veterinary; D007559:Ivermectin / Q000627:therapeutic use*; D007958:Leukocyte Count / Q000662:veterinary; D008297:Male; D010270:Parasite Egg Count; D011897:Random Allocation; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy / Q000469:parasitology / Q000503:physiopathology; D013997:Time Factors
chemical_list: D000977:Antiparasitic Agents; D007559:Ivermectin