title: Challenging the rationale of routine vasopressor therapy for management of hypotension.
abstract: There is persuasive evidence, including the present report by Dubin and colleagues, of a dissociation between increases in arterial pressure produced by vasopressor agents and improvement in microvascular perfusion and delivery of vital substrates. Especially in settings of septic shock, the current routine administration of adrenergic vasopressor therapy therefore may fail to reverse the primary defect.
authors.affiliation: Weil Institute of Critical Care Medicine, Rancho Mirage, CA 92270, USA. weilm@weiliccm.org
authors.forename: Max Harry
authors.initials: MH
authors.lastname: Weil
authors.forename: Wanchun
authors.initials: W
authors.lastname: Tang
mesh_terms: D001794:Blood Pressure / Q000187:drug effects; D006801:Humans; D007022:Hypotension / Q000188:drug therapy*; D014662:Vasoconstrictor Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D014662:Vasoconstrictor Agents
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