title: Measurement of donor kidney functional renal volume and glomerular filtration rate to predict allograft function during the post-transplantation period.
abstract: BACKGROUND
  We measured donor kidney weight (D-KW), functional renal volume (D-FRV), and single-kidney glomerular filtration rate (D-SKGFR), and then evaluated the impact of the indices to recipient body weight (R-BW) on graft function.
  
  
  METHODS
  This study included 44 recipients of live donor transplants without delayed graft function or acute rejection within 2 years of transplantation.
  
  
  RESULTS
  There was a statistically significant difference in serum creatinine between recipients with a D-KW/R-BW ratio of <or=4.25, D-FRV/R-BW ratio of <or=5.14, or D-SKGFR/R-BW ratio of <or=1.06 and recipients with a D-KW/R-BW ratio of >4.25, D-FRV/R-BW ratio of >5.14, or D-SKGFR/R-BW ratio of >1.06, respectively. D-KW/R-BW, D-FRV/R-BW, and D-SKGFR/R-BW strongly correlated with serum creatinine at 1 year and 2 years post-transplantation. In multivariate analysis, D-FRV and donor age were statistically significant risk factors which influenced serum creatinine at 1 year and 2 years post-transplantation.
  
  
  CONCLUSIONS
  D-FRV/R-BW and donor age have significant impact on graft function. D-FRV/R-BW can be measured ahead of surgery. Therefore, measuring the D-FRV is useful to select a more optimal donor kidney among otherwise similar candidates during preoperative evaluation to improve posttransplant graft function.
authors.affiliation: Department of Surgery, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Kyu Ha
authors.initials: KH
authors.lastname: Huh
authors.forename: Mijin
authors.initials: M
authors.lastname: Yun
authors.forename: Tae Sung
authors.initials: TS
authors.lastname: Kim
authors.forename: Arthur
authors.initials: A
authors.lastname: Cho
authors.forename: Jong Doo
authors.initials: JD
authors.lastname: Lee
authors.forename: Sung Min
authors.initials: SM
authors.lastname: Myoung
authors.forename: Yu Seun
authors.initials: YS
authors.lastname: Kim
authors.forename: Myoung Soo
authors.initials: MS
authors.lastname: Kim
mesh_terms: D000328:Adult; D005260:Female; D005919:Glomerular Filtration Rate; D006084:Graft Rejection / Q000175:diagnosis* / Q000209:etiology*; D006801:Humans; D007668:Kidney / Q000000981:diagnostic imaging*; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D011184:Postoperative Period; D011866:Radioisotope Renography / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D016896:Treatment Outcome; D055815:Young Adult