Epidermal growth factor receptor-regulated miR-125a-5p--a metastatic inhibitor of lung cancer.
Both the epidermal growth factor receptor signaling pathway and microRNA (miRNA) play an important role in lung cancer development and progression. To address the potential role of miRNA in epidermal growth factor receptor signaling, we identified miR-125a-5p as a downstream target, using an miRNA array. We further demonstrated that miR-125a-5p inhibited migration and invasion of lung cancer cells. Moreover, miR-125a-5p regulated the expression of several downstream genes of epidermal growth factor receptor signaling. Importantly, examination of lung cancer samples revealed a significant correlation of miR-125a-5p repression with lung carcinogenesis. Taken together, our results provide compelling evidence that miR-125a-5p, an epidermal growth factor-signaling-regulated miRNA, may function as a metastatic suppressor.
Wang
Guofu
G
Department of Respiratory Disease, Zhejiang Hospital, Hangzhou, China.
Mao
Weimin
W
Zheng
Shu
S
Ye
Jingjia
J
D045744:Cell Line, Tumor; D002465:Cell Movement / Q000235:genetics; D002470:Cell Survival; D066246:ErbB Receptors / Q000378:metabolism*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000378:metabolism* / Q000556:secondary; D020935:MAP Kinase Signaling System; D035683:MicroRNAs / Q000037:antagonists & inhibitors / Q000235:genetics*; D009361:Neoplasm Invasiveness / Q000235:genetics; D016372:RNA, Antisense / Q000235:genetics; D012334:RNA, Neoplasm / Q000235:genetics*; D015398:Signal Transduction
C531888:MIRN125 microRNA, human; D035683:MicroRNAs; D016372:RNA, Antisense; D012334:RNA, Neoplasm; D066246:ErbB Receptors
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