title: Synthesis and anticonvulsant activity of substituted oxadiazole and thiadiazole derivatives.
abstract: A series of five membered heterocyclics was synthesized by the reaction between isoniazid and various substituted isothiocyanates and was tested for their anticonvulsant activity by determining their ability to provide protection against convulsions induced by electroconvulsometer. Among the synthesized compounds, (IIf) 2-(4-chlorophenyl)amino-5-(4-pyridyl)-1,3,4-thiadiazole and (IIIf) 2-(4-chlorophenyl)amino-5-(4-pyridyl)-1, 3, 4-oxadiazole were found promising compounds of the series.
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard, New Delhi-110062, India. yarmsy@yahoo.co.in
authors.forename: Mohammad Shahar
authors.initials: MS
authors.lastname: Yar
authors.forename: Mohammad Wasim
authors.initials: MW
authors.lastname: Akhter
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000494:pharmacology; D051379:Mice; D010069:Oxadiazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013830:Thiadiazoles / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000927:Anticonvulsants; D010069:Oxadiazoles; D013830:Thiadiazoles