title: Aortic dissection in pregnancy: a life-threatening disease and a diagnosis of worth considering.
abstract: Acute aortic dissection is a life-threatening disease. To increase the awareness of this diagnosis as a cause of feto-maternal mortality during pregnancy, we have analyzed risk factors using information from five pregnant women admitted for acute aortic dissection to the Karolinska University Hospital over an eight-year period (1999-2007). Four of the women died and only one survived. One fetus was stillborn and all newborn infants showed signs of asphyxia at birth. Of the women, who were on average five years above the mean age for delivery in Sweden, three had hypertension, two had first-degree relatives with aortic dissection which had occurred during the second half of pregnancy (gestational age at diagnosis 26-41 weeks). The most common presenting symptoms were severe back, abdominal and leg pain, and confusion. If a rapid diagnosis is not made, the risk of mortality for both mother and fetus is high. The incidence of aortic rupture during pregnancy in Sweden appears to be 14.5/1,000,000 and the case maternal fatality ratio 4.4/1,000,000.
authors.affiliation: Department of Obstetrics and Gynecology, Karolinska University Hospital, Stockholm, Sweden. Josefine.Nasiell@karolinska.se
authors.forename: Josefine
authors.initials: J
authors.lastname: Nasiell
authors.forename: Mikael
authors.initials: M
authors.lastname: Norman
authors.forename: Pelle G
authors.initials: PG
authors.lastname: Lindqvist
authors.forename: Jonas
authors.initials: J
authors.lastname: Malmstedt
authors.forename: Roger
authors.initials: R
authors.lastname: Bottinga
authors.forename: Mats
authors.initials: M
authors.lastname: Blennow
mesh_terms: D000328:Adult; D000784:Aortic Dissection / Q000175:diagnosis* / Q000453:epidemiology; D001014:Aortic Aneurysm / Q000175:diagnosis* / Q000453:epidemiology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008428:Maternal Mortality; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000175:diagnosis* / Q000453:epidemiology; D013548:Sweden / Q000453:epidemiology