title: Low-dose neuroleptic therapy and extrapyramidal side effects in schizophrenia: An effect size analysis.
abstract: A meta-analysis of the published literature was performed in order to quantify the efficacy of low-dose neuroleptic therapy in reducing extrapyramidal side effects in schizophrenic patients. A low-dose regimen between 50-100 mg equivalents of chlorpromazine, in comparison to a standard-dose regimen between 200-500 mg reduced extrapyramidal side effects by a 0.30 (+/-0.12) standard deviation, which is only a limited effect.
authors.forename: C
authors.initials: C
authors.lastname: Barbui
authors.forename: B
authors.initials: B
authors.lastname: Saraceno