title: CNS activation and regional connectivity during pantomime observation: no engagement of the mirror neuron system for deaf signers.
abstract: Deaf signers have extensive experience using their hands to communicate. Using fMRI, we examined the neural systems engaged during the perception of manual communication in 14 deaf signers and 14 hearing non-signers. Participants passively viewed blocked video clips of pantomimes (e.g., peeling an imaginary banana) and action verbs in American Sign Language (ASL) that were rated as meaningless by non-signers (e.g., TO-DANCE). In contrast to visual fixation, pantomimes strongly activated fronto-parietal regions (the mirror neuron system, MNS) in hearing non-signers, but only bilateral middle temporal regions in deaf signers. When contrasted with ASL verbs, pantomimes selectively engaged inferior and superior parietal regions in hearing non-signers, but right superior temporal cortex in deaf signers. The perception of ASL verbs recruited similar regions as pantomimes for deaf signers, with some evidence of greater involvement of left inferior frontal gyrus for ASL verbs. Functional connectivity analyses with left hemisphere seed voxels (ventral premotor, inferior parietal lobule, fusiform gyrus) revealed robust connectivity with the MNS for the hearing non-signers. Deaf signers exhibited functional connectivity with the right hemisphere that was not observed for the hearing group for the fusiform gyrus seed voxel. We suggest that life-long experience with manual communication, and/or auditory deprivation, may alter regional connectivity and brain activation when viewing pantomimes. We conclude that the lack of activation within the MNS for deaf signers does not support an account of human communication that depends upon automatic sensorimotor resonance between perception and action.
authors.affiliation: Laboratory for Language and Cognitive Neuroscience, San Diego State University, 6495 Alvarado Road, San Diego, CA 92120, USA. kemmorey@mail.sdsu.edu
authors.forename: Karen
authors.initials: K
authors.lastname: Emmorey
authors.forename: Jiang
authors.initials: J
authors.lastname: Xu
authors.forename: Patrick
authors.initials: P
authors.lastname: Gannon
authors.forename: Susan
authors.initials: S
authors.lastname: Goldin-Meadow
authors.forename: Allen
authors.initials: A
authors.lastname: Braun
mesh_terms: D000328:Adult; D002490:Central Nervous System / Q000502:physiology*; D003638:Deafness / Q000503:physiopathology*; D005260:Female; D005403:Fixation, Ocular / Q000502:physiology; D007839:Functional Laterality / Q000502:physiology; D005868:Gestures; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D009044:Motor Cortex / Q000502:physiology; D009434:Neural Pathways / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D010296:Parietal Lobe / Q000502:physiology; D012813:Sign Language; D014796:Visual Perception / Q000502:physiology*; D055815:Young Adult
references.citation: Neuroimage. 2003 Apr;18(4):928-37
references.pmid: 12725768
references.citation: Trends Cogn Sci. 2000 Jul;4(7):267-278
references.pmid: 10859571
references.citation: Brain Lang. 1992 Oct;43(3):414-47
references.pmid: 1446211
references.citation: Neuropsychologia. 2008;46(9):2371-82
references.pmid: 18433807
references.citation: Brain Res Cogn Brain Res. 2004 Jul;20(2):111-9
references.pmid: 15183384
references.citation: Brain Res. 2007 Jun 4;1152:111-29
references.pmid: 17459349
references.citation: Annu Rev Neurosci. 2004;27:169-92
references.pmid: 15217330
references.citation: Neurocase. 2001;7(6):445-58
references.pmid: 11788737
references.citation: J Cogn Neurosci. 2008 Oct;20(10):1866-77
references.pmid: 18370602
references.citation: Trends Cogn Sci. 2008 Nov;12(11):432-40
references.pmid: 18805728
references.citation: Eur J Neurosci. 2001 Jan;13(2):400-4
references.pmid: 11168545
references.citation: Cognition. 2008 May;107(2):433-59
references.pmid: 18083155
references.citation: Exp Brain Res. 2001 Aug;139(3):311-7
references.pmid: 11545470
references.citation: Hum Brain Mapp. 2006 Jan;27(1):63-76
references.pmid: 15966001
references.citation: Neuroimage. 2004 Aug;22(4):1605-18
references.pmid: 15275917
references.citation: Curr Biol. 2006 Oct 10;16(19):1905-10
references.pmid: 17027486
references.citation: Neuroimage. 2002 Jan;15(1):265-72
references.pmid: 11771994
references.citation: Neuropsychologia. 2009 May;47(6):1449-59
references.pmid: 18692079
references.citation: Proc Natl Acad Sci U S A. 1998 Feb 3;95(3):922-9
references.pmid: 9448260
references.citation: J Physiol Paris. 2008 Jan-May;102(1-3):71-9
references.pmid: 18472404
references.citation: Neuroimage. 2003 Jul;19(3):777-83
references.pmid: 12880806
references.citation: Brain Lang. 1989 Jan;36(1):117-26
references.pmid: 2917283
references.citation: Cereb Cortex. 2005 Aug;15(8):1089-102
references.pmid: 15616134
references.citation: Philos Trans R Soc Lond B Biol Sci. 2007 Apr 29;362(1480):659-69
references.pmid: 17301027
references.citation: Neuropsychologia. 2002;40(7):801-7
references.pmid: 11900730
references.citation: Neuroimage. 2007 Oct 1;37(4):1315-28
references.pmid: 17689268
references.citation: J Cogn Neurosci. 2000 Sep;12(5):711-20
references.pmid: 11054914
references.citation: Brain Res Cogn Brain Res. 2003 Feb;15(3):296-307
references.pmid: 12527103
references.citation: J Neurosci. 2008 Nov 12;28(46):11900-5
references.pmid: 19005055
references.citation: Nat Neurosci. 2004 May;7(5):542-8
references.pmid: 15107859
references.citation: Cogn Neuropsychol. 2004 Jul 1;21(5):537-54
references.pmid: 21038221
references.citation: Neuropsychologia. 2004;42(11):1435-46
references.pmid: 15246282
references.citation: Am Ann Deaf. 1993 Oct;138(4):370-5
references.pmid: 8273709
references.citation: Cereb Cortex. 2005 Aug;15(8):1243-9
references.pmid: 15616133
references.citation: Exp Brain Res. 1996 Nov;112(1):103-11
references.pmid: 8951412
references.citation: Neuroimage. 2000 Jul;12(1):1-13
references.pmid: 10875897
references.citation: J Cogn Neurosci. 2007 Dec;19(12):1950-63
references.pmid: 17892384
references.citation: Brain. 1997 Oct;120 ( Pt 10):1763-77
references.pmid: 9365369
references.citation: Neurology. 2007 Dec 4;69(23):2136-45
references.pmid: 18056577
references.citation: Trends Cogn Sci. 1998 Apr 1;2(4):129-36
references.pmid: 21227109