title: A rare case of brucine poisoning complicated by rhabdomyolysis and acute renal failure.
abstract: Brucine is the predominant alkaloid present in the bark of the tree Strychnos nux vomica and is a weaker alkaloid when compared to strychnine. However, its toxicological property is akin to strychnine. We report a rare case of brucine poisoning complicated by acute renal failure and rhabdomyolysis. A 24-year-old male presented with a history of consumption of a decoction made from the bark of the Strychnos nux vomica tree. Soon after, he developed widespread muscle spasms and convulsions, which were promptly treated. On the fifth day of admission, he developed features of rhabdomyolysis and acute renal failure. Investigations revealed elevated creatine phosphokinase levels and elevated blood urea and serum creatinine. The patient was managed with hemodialysis and recovered gradually. There are many reports of strychnine poisoning producing rhabdomyolysis and renal failure. In this case report, attention is drawn to the fact that brucine, although a weaker alkaloid, can also produce life threatening complications like rhabdomyolysis and acute renal failure.
authors.affiliation: Alvas Health Centre, Moodabidri, Mangalore, Karnataka, India. sadanandanaik2@gmail.com
authors.forename: B Sadananda
authors.initials: BS
authors.lastname: Naik
authors.forename: M
authors.initials: M
authors.lastname: Chakrapani
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000473:pathology; D003402:Creatine Kinase / Q000097:blood; D006801:Humans; D008297:Male; D010936:Plant Extracts / Q000506:poisoning; D011041:Poisoning / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D011042:Poisons / Q000009:adverse effects*; D006435:Renal Dialysis; D012206:Rhabdomyolysis / Q000139:chemically induced* / Q000473:pathology; D012640:Seizures / Q000139:chemically induced; D013331:Strychnine / Q000031:analogs & derivatives* / Q000506:poisoning; D031461:Strychnos nux-vomica / Q000737:chemistry; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D010936:Plant Extracts; D011042:Poisons; C083806:brucine; D003402:Creatine Kinase; D013331:Strychnine