Synthesis and in vivo diuretic activity of biphenyl benzothiazole-2-carboxamide derivatives.
A series of N-{(substituted)1,3-benzothiazol-2-yl}-1,1 '-biphenyl-4-carboxamides was synthesized by reaction between biphenyl acid chloride and 2-aminobenzothiazole. The synthesized compounds were screened in vivo for diuretic activity. Among the series, N-(1,3-benzothiazol-2-yl)-1,1'-biphenyl-4-carboxamide (II) was found to be the most promising candidate.
Yar
Mohammad Shahar
MS
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard, New Delhi-110062, India. yarmsy@yahoo.co.in
Ansari
Zaheen Hasan
ZH
D000818:Animals; D052160:Benzothiazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D004232:Diuretics / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D013329:Structure-Activity Relationship
D052160:Benzothiazoles; D004232:Diuretics