title: Dynamic CT angiography and CT perfusion employing a 320-detector row CT: protocol and current clinical applications.
abstract: The aim of this study is to report the authors' initial clinical experience of a 320-detector row computed tomography (CT) scanner in cerebrovascular disorders. Volumetric CT using the full 160-mm width of the 320 detector rows enables full brain coverage in a single rotation that allows for combined time-resolved whole-brain perfusion and four-dimensional CT angiography (CTA). The protocol for the combined dynamic CTA and CT perfusion (CTP) is presented, and its potential applications in stroke, stenoocclusive disease, arteriovenous malformations and dural shunts are reviewed based on clinical examples. The combined CTA/CTP data can provide visualization of dynamic flow and perfusion as well as motion of an entire volume at very short time intervals which is of importance in a variety of pathologies with altered cerebral hemodynamics. The broad coverage enabled by 320 detector rows offers z-axis coverage allowing for whole-brain perfusion and subtracted dynamic angiography of the entire intracranial circulation.
authors.affiliation: Division of Neuroradiology, Department of Medical Imaging, University of Toronto, Toronto Western Hospital and Hospital for Sick Children, Toronto, ON, Canada.
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Salomon
authors.forename: Joe
authors.initials: J
authors.lastname: Barfett
authors.forename: Peter W A
authors.initials: PW
authors.lastname: Willems
authors.forename: Sasikhan
authors.initials: S
authors.lastname: Geibprasert
authors.forename: Susanna
authors.initials: S
authors.lastname: Bacigaluppi
authors.forename: Timo
authors.initials: T
authors.lastname: Krings
mesh_terms: D002533:Cerebral Angiography / Q000379:methods* / Q000639:trends*; D002561:Cerebrovascular Disorders / Q000000981:diagnostic imaging*; D006801:Humans; D055420:Perfusion Imaging / Q000379:methods* / Q000639:trends*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods* / Q000639:trends*
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