title: Non-small cell lung cancer presenting with neoplastic fever at diagnosis and relapse.
abstract: Fever occurs frequently in cancer patients, and neoplastic fever is a well-described paraneoplastic phenomenon in patients with lymphoma, acute leukemias, and renal cell carcinoma. It is also more commonly encountered in metastatic disease. Treatment options include disease-specific therapy, non-steroidal anti-inflammatory drugs (NSAIDs), and steroids. Lung cancer is one of the most common cancers, yet fever as a manifestation of this malignancy has not been emphasized. In this report, we describe an unusual case of non-metastatic non-small cell lung cancer (NSCLC) presenting with neoplastic fever at both diagnosis and relapse, responding on each occasion to disease-specific treatment, and provide a review of the management of neoplastic fever.
authors.affiliation: National University Cancer Institute Singapore, National University Health System, 5 Lower Kent Ridge Road, Singapore 119074, Singapore. ying_kiat_zee@nuhs.edu.sg
authors.forename: Y K
authors.initials: YK
authors.lastname: Zee
authors.forename: R A
authors.initials: RA
authors.lastname: Soo
mesh_terms: D000328:Adult; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis* / Q000532:radiotherapy / Q000601:surgery; D005334:Fever / Q000175:diagnosis*; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000532:radiotherapy / Q000601:surgery; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis*; D016896:Treatment Outcome