title: Panton-Valentine Leucocidin-related disease in England and Wales.
abstract: Within the framework of the Health Protection Agency's programme of enhanced surveillance of Staphylococcus aureus with Panton-Valentine Leucocidin (PVL-SA) in England and Wales conducted during 2005-2006, we identified 720 PVL-SA, representing a two-fold increase between 2005 (n = 224) and 2006 (n = 496). The number of PVL-methicillin-resistant S. aureus rose from 119 to 159 in that period. Isolates were referred by 112 centres and included outbreaks of PVL-related disease in community and healthcare settings. One hundred individuals had systemic disease symptoms. Planned systematic surveillance-based studies aim to better address the question of whether these increases reflect an increasing prevalence of PVL-SA and/or improved case ascertainment of PVL-related syndromes.
authors.affiliation: Staphylococcus Reference Unit, Centre for Infections, Health Protection Agency, London, UK.
authors.forename: M J
authors.initials: MJ
authors.lastname: Ellington
authors.forename: M
authors.initials: M
authors.lastname: Ganner
authors.forename: I M
authors.initials: IM
authors.lastname: Smith
authors.forename: C
authors.initials: C
authors.lastname: Perry
authors.forename: B D
authors.initials: BD
authors.lastname: Cookson
authors.forename: A M
authors.initials: AM
authors.lastname: Kearns
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001427:Bacterial Toxins / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D004739:England / Q000453:epidemiology; D005098:Exotoxins / Q000378:metabolism*; D005260:Female; D006801:Humans; D007223:Infant; D007956:Leukocidins / Q000378:metabolism*; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus / Q000378:metabolism; D008875:Middle Aged; D013203:Staphylococcal Infections / Q000453:epidemiology / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000378:metabolism*; D014852:Wales / Q000453:epidemiology
chemical_list: D001427:Bacterial Toxins; D005098:Exotoxins; D007956:Leukocidins; C078284:Panton-Valentine leukocidin