title: Evaluation of the effects of oral water and low-density barium sulphate suspension on bowel appearance on FDG-PET/CT.
abstract: The purpose of this study is to assess which of five bowel preparation regimes offers superior bowel distension and to assess if these regimes adversely affect FDG activity on PET/CT imaging. The study conformed to HIPAA regulations. Ninety patients were divided into five groups of 18 who received no oral contrast agent (group A); 900 ml of water orally (group B); or 900, 1,350, or 1,800 ml of LDB (groups C, D, E, respectively). PET/CT examinations were assessed quantitatively (bowel diameter, SUV) and qualitatively (visual assessment grading scale) for bowel distension and FDG activity by two blinded readers. ANOVA was utilized to determine if a statistically significant difference (SSD) existed between the groups in terms of distension and FDG uptake. Qualitatively superior bowel distension was observed in group C (LDB) compared to B (water) and greater distension was noted with increased volumes of LDB in C, D, and E. Quantitatively there was an SSD in mean distension between groups C and B (P < 0.001 except duodenum). Qualitatively and quantitatively there was no significant difference in bowel FDG uptake among the groups (P > 0.05). LDB as an oral contrast agent provides superior bowel distension over water and does not induce increased FDG bowel activity.
authors.affiliation: Department of Radiology, Division of Abdominal Imaging and Interventional Radiology, Massachusetts General Hospital, White 270, 55 Fruit Street, Boston, MA 02114, USA.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Blake
authors.forename: Bindu N
authors.initials: BN
authors.lastname: Setty
authors.forename: Carmel G
authors.initials: CG
authors.lastname: Cronin
authors.forename: Mannudeep
authors.initials: M
authors.lastname: Kalra
authors.forename: Nagaraj Setty
authors.initials: NS
authors.lastname: Holalkere
authors.forename: Alan J
authors.initials: AJ
authors.lastname: Fischman
authors.forename: Peter R
authors.initials: PR
authors.lastname: Mueller
authors.forename: Dushyant V
authors.initials: DV
authors.lastname: Sahani
mesh_terms: D000284:Administration, Oral; D001466:Barium Sulfate / Q000008:administration & dosage; D003287:Contrast Media / Q000008:administration & dosage; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D008297:Male; D008970:Molecular Weight; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013382:Subtraction Technique; D014057:Tomography, X-Ray Computed / Q000379:methods*; D014867:Water / Q000008:administration & dosage
chemical_list: D003287:Contrast Media; D019275:Radiopharmaceuticals; D014867:Water; D019788:Fluorodeoxyglucose F18; D001466:Barium Sulfate
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