Wnt signaling modulates pre- and postsynaptic maturation: therapeutic considerations.
Wnt signaling regulates a wealth of aspects of nervous system development and function in embryonic stages and in adulthood. The expression of Wnt ligands and components of the Wnt signaling machinery in early stages of neural development has been related to its role in neurite patterning and in synaptogenesis. Moreover, its expression in the mature nervous system suggests a role for this pathway in synaptic maintenance and function. Therefore, it is of crucial relevance the understanding of the mechanisms by which Wnt signaling regulates these processes. Herein, we discuss how different Wnt ligands, acting through different Wnt signaling pathways, operate in pre- and postsynaptic regions to modulate synapse structure and function. We also elaborate on the idea that Wnt signaling pathways are a target for the treatment of neurodegenerative diseases that affect synaptic integrity, such as Alzheimer's disease.
Farías
Ginny G
GG
Centro de Envejecimiento y Regeneración (CARE), Instituto Milenio (MIFAB), Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile.
Godoy
Juan A
JA
Cerpa
Waldo
W
Varela-Nallar
Lorena
L
Inestrosa
Nibaldo C
NC
D000818:Animals; D001369:Axons / Q000378:metabolism*; D003712:Dendrites / Q000378:metabolism*; D006801:Humans; D008024:Ligands; D008959:Models, Neurological; D009420:Nervous System / Q000196:embryology*; D016501:Neurites / Q000502:physiology; D019636:Neurodegenerative Diseases / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D013569:Synapses / Q000502:physiology*; D051153:Wnt Proteins / Q000378:metabolism*
D008024:Ligands; D051153:Wnt Proteins