title: Acute valproic acid overdose: enhance elimination with multiple-doses activated charcoal.
abstract: Multiple dose activated charcoal (MDAC) is used to enhance elimination of toxic substance in acute poisoning. However, its role in acute valproic acid (VA) overdose is controversial. The authors report a case of VA overdose that successfully recovered with MDAC treatment. The half-life of VA in the presented patient was decreased from 12 to 8 hours during MDAC administration. MDAC treatment in acute poisoning enhanced VA elimination four times than without treatment. MDAC should be considered for the treatment of acute VA intoxication.
authors.affiliation: Department of Pharmacology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
authors.forename: Suda
authors.initials: S
authors.lastname: Vannaprasaht
authors.forename: Somsak
authors.initials: S
authors.lastname: Tiamkao
authors.forename: Dhavee
authors.initials: D
authors.lastname: Sirivongs
authors.forename: Nawanant
authors.initials: N
authors.lastname: Piyavhatkul
mesh_terms: D000138:Acidosis; D000208:Acute Disease; D000328:Adult; D000931:Antidotes / Q000627:therapeutic use*; D002606:Charcoal / Q000627:therapeutic use*; D062787:Drug Overdose / Q000188:drug therapy*; D005260:Female; D015600:Glasgow Coma Scale; D006801:Humans; D012372:ROC Curve; D014635:Valproic Acid / Q000506:poisoning*
chemical_list: D000931:Antidotes; D002606:Charcoal; D014635:Valproic Acid