title: [Effect of dexmedetomidine on intraoperative somatosensory evoked potential monitoring].
abstract: BACKGROUND
  Intraoperative somatosensory-evoked potential (SEP) monitoring has become a part of neurosurgical procedures. In this study, we evaluated the effect of dexmedetomidine on SEP monitoring during neurosurgical anesthesia.
  
  
  METHODS
  Eight patients scheduled for neurosurgery were studied. Anesthesia was maintained with continuous infusion of propofol at 2 microg x ml(-1) concentration using target controlled infusion (TCI). A loading dose of dexmedetomidine was infused at 6 microg x kg(-1) hr(-1) for 10 min and SEP was recorded. Infusion of dexmedetomidine was continued at 0.5 microg x kg(-1) x min(-1) for 10 min and SEP was recorded. We measured the change of amplitude and latency of SEP (N20-P25) and compared to baseline values.
  
  
  RESULTS
  There was no statistically significant change in the cortical SEP amplitude (98.0 +/- 18.1% after a loading dose of dexmedetomidine and 112.7 +/- 16.8% at 0.5 microg x kg(-1) x min(-1) of dexmedetomidine, respectively) or latency (101.5 +/- 1.7% after a loading dose of dexmedetomidine and 101.9 +/- 1.7% at 0.5 microg x kg(-1) x min(-1) of dexmedetomidine, respectively). Mean blood pressure rose from 81 mmHg to 95 mmHg after initiation of dexmedetomidine infusion. Heart rate did not change.
  
  
  CONCLUSIONS
  These findings suggest that dexmedetomidine has possibilities to produce an ideal environment as an anesthetic adjunct in patients requiring intrapoerative SEP monitoring.
authors.affiliation: Department of Anesthesia, Chugoku Rosai General Hospital, Kure 737-0193.
authors.forename: Seiji
authors.initials: S
authors.lastname: Kajiyama
authors.forename: Itsuo
authors.initials: I
authors.lastname: Nakagawa
authors.forename: Syozo
authors.initials: S
authors.lastname: Hidaka
authors.forename: Hironori
authors.initials: H
authors.lastname: Okada
authors.forename: Takashi
authors.initials: T
authors.lastname: Kubo
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Nao
mesh_terms: D000759:Adjuvants, Anesthesia / Q000008:administration & dosage / Q000494:pharmacology*; D000316:Adrenergic alpha-Agonists / Q000008:administration & dosage / Q000494:pharmacology*; D000368:Aged; D000758:Anesthesia; D020927:Dexmedetomidine / Q000008:administration & dosage / Q000494:pharmacology*; D005073:Evoked Potentials, Somatosensory / Q000187:drug effects*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative; D019635:Neurosurgical Procedures; D015742:Propofol
chemical_list: D000759:Adjuvants, Anesthesia; D000316:Adrenergic alpha-Agonists; D020927:Dexmedetomidine; D015742:Propofol