Myelination in bipolar patients and the effects of mood stabilizers on brain anatomy.
In this review, we debate the evidence for abnormal white matter microstructure and myelination in bipolar disorder, as mainly detected by diffusion tensor imaging (DTI) studies. The effects of mood stabilizers on white matter are discussed, based on available findings from human and animal studies. Last, perspectives in this field of research are also drawn.
Brambilla
Paolo
P
Inter-University Center for Behavioural Neurosciences, Department of Pathology and Experimental & Clinical Medicine, Section of Psychiatry, University of Udine, Udine, Italy. paolo.brambilla@uniud.it
Bellani
Marcella
M
Yeh
Ping-Hong
PH
Soares
Jair C
JC
D000818:Animals; D001714:Bipolar Disorder / Q000188:drug therapy / Q000473:pathology*; D001921:Brain / Q000187:drug effects / Q000473:pathology*; D038524:Diffusion Magnetic Resonance Imaging; D006801:Humans; D018020:Lithium Compounds / Q000494:pharmacology*; D009186:Myelin Sheath / Q000187:drug effects* / Q000502:physiology*; D009434:Neural Pathways / Q000187:drug effects / Q000473:pathology; D014635:Valproic Acid / Q000494:pharmacology*
D018020:Lithium Compounds; D014635:Valproic Acid