Multiplicity of diverse heterocycles from polymer-supported alpha-acylamino ketones.
Polymer-supported alpha-acylamino ketones were transformed to seven types of structurally unrelated heterocyclic compounds. Syntheses involved variety of chemical routes and comprised diverse chemistries (C-C, C=C, C-N, C=N, and C-O bond formations). Different sizes of heterocycles (4-, 5-, 6-, and 7-membered rings) were prepared, including dihydro-pyrrol-2-ones, pyrazin-2-ones, dihydro-triazepin-6-ones, morpholin-3-ones, imidazoles, beta-lactams, and isoquinolin-1-ones. Further elaboration to fused ring systems was also documented.
Pudelová
Nadezda
N
Department of Chemistry and Biochemistry, 251 Nieuwland Science Center, University of Notre Dame, Notre Dame, Indiana 46556, USA.
Krchnák
Viktor
V
D000215:Acylation; D000588:Amines / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D011108:Polymers / Q000737:chemistry*
D000588:Amines; D006571:Heterocyclic Compounds; D007659:Ketones; D011108:Polymers
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