Coenzyme Q10 treatment reduces lipid peroxidation, inducible and endothelial nitric oxide synthases, and germ cell-specific apoptosis in a rat model of testicular ischemia/reperfusion injury.
In this experimental study, we assessed the preventive effects of coenzyme Q(10) (CoQ(10)) in a rat model of ischemia/reperfusion injury. The results of this study show that CoQ(10) administration before the reperfusion period of testicular torsion provides a significant decrease in testicular lipid peroxidation products and expressions of inducible nitric oxide synthase, endothelial nitric oxide synthase, and germ cell-specific apoptosis.
Erol
Bulent
B
Department of Urology, Zonguldak Karaelmas University Faculty of Medicine, Zonguldak, Turkey.
Bozlu
Murat
M
Hanci
Volkan
V
Tokgoz
Husnu
H
Bektas
Sibel
S
Mungan
Gorkem
G
D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D004195:Disease Models, Animal; D015536:Down-Regulation; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D052247:Nitric Oxide Synthase Type II / Q000378:metabolism*; D052250:Nitric Oxide Synthase Type III / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000201:enzymology / Q000473:pathology / Q000517:prevention & control*; D013086:Spermatic Cord Torsion / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D013737:Testis / Q000098:blood supply / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000494:pharmacology
D014451:Ubiquinone; D052247:Nitric Oxide Synthase Type II; D052250:Nitric Oxide Synthase Type III; C496318:Nos2 protein, rat; C496316:Nos3 protein, rat; C024989:coenzyme Q10