Water uptake by substituted amylose tablets: experimentation and numerical simulation.
BACKGROUND
Substituted amylose (SA) has been developed as excipient for direct compression matrices in the formulation of sustained release solid dosage forms.


METHODS
The gel performance of SA for controlling water diffusion was studied by measuring water content in SA tablets prepared by direct compression.


RESULTS
The SA gel was not freely swelling and results indicate that water content in equilibrium state was dependent on tablet size but not on compression force. The presence of electrolyte and hydrophobic lubricant played an effective role in adjusting water diffusion in SA gel. In addition, a numerical model based on finite difference method was developed that exhibits a high goodness of fit to experimental result. The output of the model was not only the macroscopic water content value but also the water distribution within SA tablets.
Wang
H W
HW
Faculty of Pharmacy, University of Montreal, Montreal, QC, Canada.
Kyriacos
S
S
Cartilier
L
L
D000042:Absorption; D000688:Amylose / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry*; D019245:Compressive Strength; D003198:Computer Simulation; D004058:Diffusion; D004573:Electrolytes / Q000737:chemistry; D020100:Hydrogels / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D008422:Materials Testing; D011108:Polymers / Q000737:chemistry*; D013607:Tablets; D014867:Water / Q000737:chemistry*
D004573:Electrolytes; D020100:Hydrogels; D011108:Polymers; D013607:Tablets; D014867:Water; D000688:Amylose