title: Computational fluid dynamics of aggregating red blood cells in postcapillary venules.
abstract: Aggregate formation of red blood cells (RBCs) in a postcapillary venular bifurcation is investigated with three-dimensional computer simulations using the Chimera grid method. Interaction energy between the RBCs is modelled by a depletion interaction theory; RBCs are modelled as rigid oblate ellipsoids. The cell-cell interactions of RBCs are strongly dependent on vessel geometry and shear rates. The experimental data on vessel geometry, pseudoshear rates, and Dextran concentration obtained in our previous in vivo RBC aggregation study in postcapillary venules of the rat spinotrapezius muscle were used to simulate RBC aggregation. The computational results were compared to the experimental results from the in vivo study. The results show that cells have a larger tendency to form an aggregate under reduced flows. Aggregate formation also depends on the angle and location of the cells before they enter the bifurcation region. Comparisons with experimental data are discussed.
authors.affiliation: Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, USA. bchung6@jhu.edu
authors.forename: Bong
authors.initials: B
authors.lastname: Chung
authors.forename: Sangho
authors.initials: S
authors.lastname: Kim
authors.forename: Paul C
authors.initials: PC
authors.lastname: Johnson
authors.forename: Aleksander S
authors.initials: AS
authors.lastname: Popel
mesh_terms: D000818:Animals; D001698:Biomedical Engineering; D001783:Blood Flow Velocity; D002449:Cell Aggregation / Q000502:physiology*; D003198:Computer Simulation; D004912:Erythrocytes / Q000166:cytology / Q000502:physiology*; D021621:Imaging, Three-Dimensional; D008955:Models, Cardiovascular; D051381:Rats; D014699:Venules / Q000033:anatomy & histology* / Q000502:physiology*
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