AtEHDs in endocytosis.
Endocytosis regulates many important and diverse processes in eukaryotic life. EH domain containing proteins function as regulators of endocytosis through protein-protein interactions. Several interactors of mammalian EHDs were identified, including clathrin machinery components. The four human EHD proteins share high homology at the protein level and possess similar domains, but appear to be involved in different stages of intracellular trafficking. EHD1 regulates recycling through the endocytic recycling compartment (ERC). EHD2 has been found to inhibit internalization in mammalians when overexpressed.We have recently investigated the importance of EH domain containing proteins in plant endocytosis. We were able to show that both of the Arabidopsis EHD homologs, termed AtEHD1 and AtEHD2, play important roles in plant endocytosis. Knockdown of AtEHD1 delayed internalization, and overexpression of AtEHD2 inhibited endocytosis. Thus, the function of plant EHDs is highly homologous to that of mammalian EHDs.
Bar
Maya
M
Department of Plant Sciences; Tel-Aviv University; Tel-Aviv Israel.
Benjamin
Sigi
S
Horowitz
Mia
M
Avni
Adi
A
EMBO J. 2001 Sep 3;20(17):4730-41
11532937
Trends Biochem Sci. 1997 Nov;22(11):411-3
9397678
Nat Cell Biol. 2001 Jun;3(6):573-9
11389442
Genomics. 1999 Jul 1;59(1):66-76
10395801
Plant J. 2008 Sep;55(6):1025-38
18547399
Plant Cell. 2004 Jun;16(6):1604-15
15155877
Plant Signal Behav. 2007 Nov;2(6):556-8
19704558
Exp Cell Res. 2007 Jan 15;313(2):219-31
17097635
Nat Cell Biol. 2001 Jun;3(6):567-72
11389441
J Biol Chem. 2001 Aug 31;276(35):33054-60
11423532
BMC Cell Biol. 2007 Jan 18;8:3
17233914
Plant Cell. 2007 Jan;19(1):296-319
17209124
Curr Biol. 2007 Mar 20;17(6):520-7
17306539
Trends Cell Biol. 2005 Aug;15(8):425-33
16006126
Traffic. 2002 Aug;3(8):575-89
12121420
Mol Biol Cell. 2004 May;15(5):2410-22
15020713
BMC Plant Biol. 2008 Jan 08;8:3
18179725
Nat Rev Mol Cell Biol. 2005 Feb;6(2):112-26
15687999
Mol Biol Cell. 2005 Aug;16(8):3642-58
15930129
Trends Plant Sci. 2007 Nov;12(11):497-505
17920331
Nat Rev Immunol. 2005 Jun;5(6):446-58
15928677
Physiol Rev. 1997 Jul;77(3):759-803
9234965
Plant J. 2008 Jan;53(2):237-47
17999644
EMBO J. 2002 Jun 3;21(11):2557-67
12032069
J Biol Chem. 2004 Mar 12;279(11):10593-605
14676205
J Cell Sci. 2005 Sep 15;118(Pt 18):4093-101
16155252
Traffic. 2007 Dec;8(12):1873-1886
17868075
Eur J Cell Biol. 2005 Jun;84(6):609-21
16032929
Traffic. 2006 Jan;7(1):52-60
16445686
Annu Rev Plant Biol. 2005;56:221-51
15862095