title: A new tetrahydrofuran derivative from the endophytic fungus Chaetomium sp. isolated from Otanthus maritimus.
abstract: A hitherto unidentified endophytic strain of the genus Chaetomium, isolated from the medicinal plant Otanthus maritimus, yielded a new tetrahydrofuran derivative, aureonitolic acid (1), along with 5 known natural products, 2-6. The structure of 1 was determined by extensive spectroscopic analysis and comparison with reported data. Extracts of the fungus, grown either in liquid culture or on solid rice media, exhibited considerable cytotoxic activity when tested in vitro against L5178Y mouse lymphoma cells. Compounds 2 and 6 showed significant growth inhibition against L5178Y cells with EC50 values of 7.0 and 2.7 microg/mL, respectively, whereas 1 was inactive.
authors.affiliation: Institut für Pharmazeutische Biologie und Biotechnologie, Heinrich-Heine-Universittät, Universitätsstrasse 1, Geb. 26.23, D-40225 Düsseldorf, Germany.
authors.forename: Amal H
authors.initials: AH
authors.lastname: Aly
authors.forename: Abdessamad
authors.initials: A
authors.lastname: Debbab
authors.forename: RuAngelie
authors.initials: R
authors.lastname: Edrada-Ebel
authors.forename: Victor
authors.initials: V
authors.lastname: Wray
authors.forename: Werner E G
authors.initials: WE
authors.lastname: Müller
authors.forename: Wenhan
authors.initials: W
authors.lastname: Lin
authors.forename: Rainer
authors.initials: R
authors.lastname: Ebel
authors.forename: Peter
authors.initials: P
authors.lastname: Proksch
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D019659:Asteraceae / Q000382:microbiology*; D045744:Cell Line, Tumor / Q000187:drug effects; D002597:Chaetomium / Q000737:chemistry* / Q000302:isolation & purification; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D007940:Leukemia L5178 / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D013058:Mass Spectrometry / Q000379:methods; D051379:Mice; D010946:Plants, Medicinal / Q000382:microbiology; D011048:Polarography
chemical_list: D000970:Antineoplastic Agents; D005663:Furans