Structural and pharmacological features of phospholipases A2 from snake venoms.
Phospholipases A(2) enzymes are found in many biological sources, including snake venoms. Here we reviewed aspects of PLA(2)s including biological and structural features, interaction with binding receptors, inhibitors used on structure-function relationship studies and highlighting the mechanism of action and role of the snake venom PLA(2)s products, the lysophosphatidylcholine.
de Paula
Rafael Cisne
RC
Departamento de Biologia Celular e Molecular, Instituto de Biologia, Universidade Federal Fluminense, Niterói, RJ, Brasil.
Castro
Helena Carla
HC
Rodrigues
Carlos Rangel
CR
Melo
Paulo Assis
PA
Fuly
André Lopes
AL
D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D064801:Phospholipase A2 Inhibitors; D054467:Phospholipases A2 / Q000737:chemistry* / Q000494:pharmacology*; D016415:Sequence Alignment; D012910:Snake Venoms / Q000201:enzymology*; D012911:Snakes
D064801:Phospholipase A2 Inhibitors; D012910:Snake Venoms; D054467:Phospholipases A2