Gender effects on association of serotonin transporter gene polymorphism with symptoms of central fatigue.
In order to test the "serotonin" hypothesis of the genesis of central fatigue, we studied association between genotype and fatigue (3-hour mental workload consisting of information processing and logical task solution) using analysis of variance for different indices (well-being, activity, mood, mental fatigue index). It was concluded that young men with serotonin deficit (LL genotype) and girls with serotonin excess (S genotype) were less tolerant to long-lasting mental workload. Thus, we confirmed that the degree of central fatigue depends on the function of the serotonin system and revealed gender differences in adaptive capacities of carriers of different variants of serotonin transporter.
Maluchenko
N V
NV
Biological Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia. mal_nat@mail.ru
Schegolkova
J V
JV
Kulikova
M A
MA
Timofeeva
M A
MA
Shlepcova
V A
VA
Sysoeva
O V
OV
Tonevitsky
A G
AG
D000339:Affect; D000483:Alleles; D000704:Analysis of Variance; D005221:Fatigue / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008606:Mental Processes; D009483:Neuropsychological Tests; D011110:Polymorphism, Genetic; D011581:Psychological Tests; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D012727:Sex Characteristics; D011795:Surveys and Questionnaires; D055815:Young Adult
C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins