Antihyperglycemic activity of phenylpropanoyl esters of catechol glycoside and its dimers from Dodecadenia grandiflora.
Bioactivity-guided separation of an antihyperglycemic extract from the leaves of Dodecadenia grandiflora afforded two phenylpropanoyl esters of catechol glycosides (1 and 4) and two lignane bis(catecol glycoside)esters (2 and 3). Their structures were established on the basis of extensive spectroscopic analysis (1D and 2D-NMR, MS). Compounds 2 and 3 are believed to be derived from dimerization via the two phenylpropanoid units of 1. Compounds 1-4 showed significant antihyperglycemic activity in streptozotocin-induced (STZ) diabetic rats, which is comparable to the standard drug metformin. Our results provide support to explain the use of D. grandiflora as antihyperglycemic agent by the traditional medical practitioners.
Kumar
Manmeet
M
Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow 226 001, India.
Rawat
Preeti
P
Rahuja
Neha
N
Srivastava
Arvind Kumar
AK
Maurya
Rakesh
R
D000818:Animals; D002396:Catechols / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D019281:Dimerization; D004952:Esters / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D007004:Hypoglycemic Agents / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D019770:Lauraceae / Q000737:chemistry*; D008297:Male; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D018515:Plant Leaves; D051381:Rats; D017207:Rats, Sprague-Dawley
D002396:Catechols; D004952:Esters; D006027:Glycosides; D007004:Hypoglycemic Agents; D010636:Phenols; D010936:Plant Extracts; C545977:dodegranoside A; C545978:dodegranoside B; C545979:dodegranoside C; C545980:dodegranoside D; C034221:catechol