Genome-wide linkage analysis in a Dutch multigenerational family with attention deficit hyperactivity disorder.
Attention deficit hyperactivity disorder (ADHD) is a common neuropsychiatric disorder. Genetics has an important role in the aetiology of this disease. In this study, we describe the clinical findings in a Dutch family with eight patients suffering from ADHD, in whom five had at least one other psychiatric disorder. We performed a genome-wide (parametric and nonparametric) affected-only linkage analysis. Two genomic regions on chromosomes 7 and 14 showed an excess of allele sharing among the definitely affected members of the family with suggestive LOD scores (2.1 and 2.08). Nonparametric linkage analyses (NPL) yielded a maxNPL of 2.92 (P=0.001) for marker D7S502 and a maxNPL score of 2.56 (P=0.003) for marker D14S275. We confirmed that all patients share the same haplotype in each region of 7p15.1-q31.33 and 14q11.2-q22.3. Interestingly, both loci have been reported before in Dutch (affected sib pairs) and German (extended families) ADHD linkage studies. Hopefully, the genome-wide association studies in ADHD will help to highlight specific polymorphisms and genes within the broad areas detected by our, as well as other, linkage studies.
Vegt
Rinus
R
Department of Psychiatry, Erasmus Medical Centre, Rotterdam, The Netherlands.
Bertoli-Avella
Aida M
AM
Tulen
Joke H M
JH
de Graaf
Bianca
B
Verkerk
Annemieke J M H
AJ
Vervoort
Jeroen
J
Twigt
Carla M
CM
Maat-Kievit
Anneke
A
van Tuijl
Ruud
R
van der Lijn
Marieke
M
Hengeveld
Michiel W
MW
Oostra
Ben A
BA
D001289:Attention Deficit Disorder with Hyperactivity / Q000235:genetics*; D002869:Chromosome Aberrations; D002874:Chromosome Mapping; D002883:Chromosomes, Human, Pair 14; D002897:Chromosomes, Human, Pair 7; D015897:Comorbidity; D005260:Female; D005819:Genetic Markers; D055106:Genome-Wide Association Study / Q000379:methods*; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics; D009426:Netherlands; D010375:Pedigree
D005819:Genetic Markers
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