Palivizumab: a review of its use in the protection of high risk infants against respiratory syncytial virus (RSV).
Respiratory syncytial virus (RSV) is a leading cause of hospitalization in children less than 1 year of age and causes substantial morbidity. Although there is not currently a vaccine available to prevent RSV infection, prophylaxis with the humanized monoclonal antibody palivizumab has been shown to reduce the rate of RSV hospitalization in premature infants and those infants with chronic lung disease or congenital heart disease. Because palivizumab has not been shown to have a beneficial clinical effect on established RSV disease such as reducing the rate of mechanical ventilation and mortality in children afflicted with RSV, there has been considerable debate as to the cost-benefit ratio of administering palivizumab according to international guidelines. Palivizumab has demonstrated a favorable side-effect profile in clinical trials without the development of anti-palivizumab antibodies. Future studies are needed to determine whether palivizumab, or other more potent monoclonal antibodies which are currently undergoing clinical trials, will reduce the long-term sequelae of RSV infection such as the development of wheezing and asthma.
Geskey
Joseph M
JM
Divisions of General Pediatrics.
Thomas
Neal J
NJ
Brummel
Gretchen L
GL
Pediatr Infect Dis J. 2001 Jun;20(6):628-30
11419509
J Infect Dis. 1998 Dec;178(6):1555-61
9815203
Pediatr Pulmonol. 2003 Jun;35(6):484-9
12746948
Pediatr Infect Dis J. 1999 Oct;18(10):866-9
10530581
Pediatr Res. 2004 Dec;56(6):914-7
15470202
Scand J Infect Dis. 2001;33(5):323-8
11440215
Pediatr Pulmonol. 2004 Aug;38(2):155-60
15211700
Pediatr Infect Dis J. 2000 Nov;19(11):1068-71
11099087
Pediatr Allergy Immunol. 2005 Aug;16(5):386-92
16101930
N Engl J Med. 1987 Aug 6;317(6):329-34
3600729
Pediatrics. 2004 Oct;114(4):e437-44
15466069
J Infect Dis. 2001 Aug 1;184(3):350-4
11443562
J Pediatr. 2000 Dec;137(6):865-70
11113845
Pediatr Infect Dis J. 2004 Dec;23(12):1081-5
15626942
Virology. 2004 Jan 20;318(2):608-12
14972528
Pediatrics. 2003 Dec;112(6 Pt 1):1442-6
14654627
Pediatr Pulmonol. 2007 Mar;42(3):189-92
17243184
Pediatr Int. 2006 Aug;48(4):362-8
16911080
J Pediatr. 2003 Jul;143(1):123-6
12915838
Arch Pediatr Adolesc Med. 2000 Jan;154(1):55-61
10632251
JAMA. 2000 Apr 26;283(16):2116-21
10791503
Pediatr Infect Dis J. 2003 Jun;22(6):540-5
12799511
Arch Dis Child. 2007 Jan;92(1):87-8
17185451
Eur J Pediatr. 2003 Apr;162(4):230-6
12647195
Thorax. 2005 Dec;60(12):1039-44
16227330
Infection. 2003 Mar;31(2):75-80
12682811
Pediatr Infect Dis J. 2003 Feb;22(2 Suppl):S46-54
12671452
Pediatr Infect Dis J. 1998 Feb;17(2):110-5
9493805
Arch Dis Child. 2001 Dec;85(6):463-8
11719328
J Infect Dis. 1997 Nov;176(5):1215-24
9359721
Clin Ther. 2004 Dec;26(12):2130-7
15823776
Pediatr Infect Dis J. 2001 Sep;20(9):874-9
11734767
Pediatr Infect Dis J. 2005 Nov;24(11):1021-3
16282947
Pediatr Infect Dis J. 2004 Sep;23(9):815-20
15361718
Acta Paediatr. 2006 Apr;95(4):404-6
16720485
Am J Transplant. 2004 Nov;4 Suppl 10:105-9
15504224
J Paediatr Child Health. 2000 Oct;36(5):422-7
11036794
Arch Dis Child Fetal Neonatal Ed. 2005 Jan;90(1):F64-8
15613580
P R Health Sci J. 2002 Sep;21(3):191-3
12243108
Arch Dis Child Fetal Neonatal Ed. 2005 Jan;90(1):F92
15613591
Arch Pediatr Adolesc Med. 2002 Oct;156(10):1034-41
12361451
J Pediatr. 1998 Oct;133(4):492-9
9787686
BMC Infect Dis. 2005 Mar 31;5:20
15801975
Pediatrics. 2003 Dec;112(6 Pt 1):1447-52
14654628
Am J Respir Crit Care Med. 2005 Jan 15;171(2):137-41
15516534
Arch Dis Child. 2004 Oct;89(10):961-5
15383442
Arch Pediatr Adolesc Med. 2002 Dec;156(12):1251-5
12444839
Ambul Pediatr. 2002 Nov-Dec;2(6):444-8
12437390
Pediatrics. 1999 Mar;103(3):619-26
10049966
Pediatr Infect Dis J. 2002 Jun;21(6):512-8
12182374
Pediatr Infect Dis J. 1998 Sep;17(9):787-91
9779762
Pediatr Infect Dis J. 2006 Apr;25(4):320-4
16567983
Chest. 2004 Jul;126(1):186-91
15249461
Pediatrics. 1997 Jan;99(1):93-9
8989345
Pediatrics. 1998 Sep;102(3):531-7
9724660
Pediatrics. 2000 Sep;106(3):520-6
10969097
N Engl J Med. 2001 Jun 21;344(25):1917-28
11419430
J Pediatr. 2003 Oct;143(4):532-40
14571236
Pediatrics. 2002 Nov;110(5):e53
12415059
Arch Dis Child. 2003 Dec;88(12):1065-9
14670770
Pediatr Pulmonol. 2002 Oct;34(4):262-6
12205567
Lancet. 1992 Oct 31;340(8827):1079-83
1357462
N Engl J Med. 1993 Nov 18;329(21):1524-30
8413475
Pediatr Infect Dis J. 2006 Aug;25(8):680-6
16874165
Chest. 2005 Oct;128(4):2765-71
16236953
J Pediatr Hematol Oncol. 2007 Apr;29(4):227-32
17414564
Arch Dis Child. 2004 Jun;89(6):562-7
15155404
Virus Res. 2005 Feb;107(2):141-9
15649560
Antimicrob Agents Chemother. 2004 May;48(5):1811-22
15105140
Arch Pediatr Adolesc Med. 2006 Oct;160(10):1070-6
17018467
Pediatrics. 2006 Oct;118(4):1774-93
17015575
J Hosp Infect. 2004 Sep;58(1):38-41
15350712
Pediatr Infect Dis J. 2000 Jul;19(7):592-7
10917214
Drug Saf. 2003;26(4):283-91
12608889
Am J Respir Crit Care Med. 2000 May;161(5):1501-7
10806145
Pediatr Infect Dis J. 2004 May;23(5):418-23
15131464
Bone Marrow Transplant. 2002 Jan;29(2):117-20
11850705
Lancet. 1999 Aug 14;354(9178):541-5
10470697
Pediatr Infect Dis J. 2003 Sep;22(9):823-7
14506376
Pediatr Infect Dis J. 2004 Aug;23(8):707-12
15295219
Pediatr Infect Dis J. 2004 Apr;23(4):342-5
15071290
J Pediatr. 2003 Nov;143(5 Suppl):S127-32
14615711
BMC Pediatr. 2004 Dec 17;4(1):25
15606912
Pediatrics. 2004 Dec;114(6):1606-11
15574622
J Infect Dis. 1990 Dec;162(6):1283-90
2230258
Eur J Clin Microbiol Infect Dis. 2006 Feb;25(2):120-2
16491302
Rev Med Virol. 2007 Jan-Feb;17(1):5-34
17004293
Antimicrob Agents Chemother. 2005 Nov;49(11):4700-7
16251314
J Infect Dis. 2004 Sep 1;190(5):975-8
15295704
Pediatrics. 2005 Sep;116(3):603-8
16140699
Pediatrics. 2004 Jun;113(6):1758-64
15173503
Arch Dis Child Fetal Neonatal Ed. 2005 Jul;90(4):F286-9
16036888
J Paediatr Child Health. 2002 Dec;38(6):550-4
12410864
Arch Dis Child. 2000 Oct;83(4):313-6
10999865
J Hosp Infect. 2001 Jul;48(3):186-92
11439005
Pediatr Pulmonol. 2002 Sep;34(3):181-8
12203846
Am J Epidemiol. 1969 Apr;89(4):449-63
4305200
Pediatr Pulmonol. 2006 Dec;41(12):1167-74
17058279
Pediatrics. 2004 Nov;114(5):e554-6
15520088
Pediatr Infect Dis J. 2004 Apr;23(4):318-22
15071285
J Pediatr. 2003 Nov;143(5 Suppl):S142-9
14615713
Pediatrics. 1999 Oct;104(4 Pt 1):894-9
10506231
Pediatr Infect Dis J. 2004 Sep;23(9):806-14
15361717
Epidemiol Infect. 2006 Jun;134(3):506-13
16638164
J Pediatr. 1995 Feb;126(2):212-9
7844667
JAMA. 2003 Jan 8;289(2):179-86
12517228
N Engl J Med. 1986 Jul 10;315(2):77-81
3724802
Acta Paediatr. 2004 Nov;93(11):1470-3
15513574
Pediatr Int. 2005 Aug;47(4):397-403
16091076
Eur J Clin Microbiol Infect Dis. 2001 Jul;20(7):452-9
11561800
Pediatr Infect Dis J. 2004 Jan;23(1):27-31
14743042
Am J Epidemiol. 1969 Apr;89(4):435-48
4305199