Genome-wide transcriptional profiling of the response of Staphylococcus aureus to cryptotanshinone.
Staphylococcus aureus (S. aureus) strains with multiple antibiotic resistances are increasingly widespread, and new agents are required for the treatment of S. aureus. Cryptotanshinone (CT), a major tanshinone of medicinal plant Salvia miltiorrhiza Bunge, demonstrated effective in vitro antibacterial activity against all 21 S. aureus strains tested in this experiment. Affymetrix GeneChips were utilized to determine the global transcriptional response of S. aureus ATCC 25923 to treatment with subinhibitory concentrations of CT. Transcriptome profiling indicated that the antibacterial action of CT may be associated with its action as active oxygen radical generator; S. aureus undergoes an oxygen-limiting state upon exposure to CT.
Feng
Haihua
H
Key Laboratory of Zoonosis, Institute of Zoonosis, College of Animal Science and Veterinary Medicine, Jilin University, Ministry of Education, Changchun, China.
Xiang
Hua
H
Zhang
Jiyu
J
Liu
Guowen
G
Guo
Na
N
Wang
Xuelin
X
Wu
Xiuping
X
Deng
Xuming
X
Yu
Lu
L
D019881:Aminoacyltransferases / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D000693:Anaerobiosis / Q000187:drug effects / Q000235:genetics; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D003546:Cysteine Endopeptidases / Q000235:genetics / Q000378:metabolism; D024881:Drug Resistance, Bacterial; D005285:Fermentation; D020869:Gene Expression Profiling / Q000379:methods*; D015964:Gene Expression Regulation, Bacterial / Q000187:drug effects; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects; D006801:Humans; D033862:Iron-Binding Proteins; D008826:Microbial Sensitivity Tests; D018384:Oxidative Stress / Q000187:drug effects / Q000235:genetics; D033902:Periplasmic Binding Proteins; D010616:Phenanthrenes / Q000494:pharmacology*; D015203:Reproducibility of Results; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013203:Staphylococcal Infections / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000235:genetics* / Q000254:growth & development / Q000378:metabolism
D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D033862:Iron-Binding Proteins; D033902:Periplasmic Binding Proteins; D010616:Phenanthrenes; C509821:sortase B; C037886:cryptotanshinone; D019881:Aminoacyltransferases; D003546:Cysteine Endopeptidases
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