Breaking the silence: stimulating proliferation of adult cardiomyocytes.
Several recent findings challenge our view of the heart as a postmitotic organ and suggest that the adult heart has some capacity to regenerate. Bersell et al. in a recent issue of Cell report that neuregulin1-mediated activation of ErbB2/4 receptors induces proliferation of adult mononuclear cardiomyocytes.
Braun
Thomas
T
Max-Planck-Institute for Heart and Lung Research, 61231 Bad Nauheim, Germany.
Dimmeler
Stefanie
S
D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D049109:Cell Proliferation; D006321:Heart / Q000196:embryology; D051379:Mice; D009200:Myocardial Contraction / Q000502:physiology; D032383:Myocytes, Cardiac / Q000502:physiology*; D020890:Neuregulin-1 / Q000378:metabolism
D020890:Neuregulin-1