Fully-automated white matter hyperintensity detection with anatomical prior knowledge and without FLAIR.
This paper presents a method for detection of cerebral white matter hyperintensities (WMH) based on run-time PD-, T1-, and T2-weighted structural magnetic resonance (MR) images of the brain along with labeled training examples. Unlike most prior approaches, the method is able to reliably detect WMHs in elderly brains in the absence of fluid-attenuated (FLAIR) images. Its success is due to the learning of probabilistic models of WMH spatial distribution and neighborhood dependencies from ground-truth examples of FLAIR-based WMH detections. These models are combined with a probabilistic model of the PD, T1, and T2 intensities of WMHs in a Markov Random Field (MRF) framework that provides the machinery for inferring the positions of WMHs in novel test images. The method is shown to accurately detect WMHs in a set of 114 elderly subjects from an academic dementia clinic. Experiments show that standard off-the-shelf MRF training and inference methods provide robust results, and that increasing the complexity of neighborhood dependency models does not necessarily help performance. The method is also shown to perform well when training and test data are drawn from distinct scanners and subject pools.
Schwarz
Christopher
C
Computer Science Department, University of California, Davis, CA 95618, USA.
Fletcher
Evan
E
DeCarli
Charles
C
Carmichael
Owen
O
D000465:Algorithms; D001185:Artificial Intelligence; D001921:Brain / Q000473:pathology*; D003711:Demyelinating Diseases / Q000473:pathology; D020833:Diffuse Axonal Injury / Q000473:pathology*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009413:Nerve Fibers, Myelinated / Q000473:pathology*; D010363:Pattern Recognition, Automated / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
Stroke. 2006 Mar;37(3):836-40
16439704
Arch Gen Psychiatry. 2003 Nov;60(11):1090-6
14609884
Neuroradiology. 2008 Jan;50(1):31-42
17938898
Neuroimage. 2005 Nov 15;28(3):607-17
16129626
Alzheimers Dement. 2005 Jul;1(1):55-66
17476317
Conf Proc IEEE Eng Med Biol Soc. 2005;2006:463-6
17282216
Arch Neurol. 2006 Feb;63(2):246-50
16476813
Psychiatry Res. 2006 Dec 1;148(2-3):133-42
17097277
Neurology. 2006 Dec 26;67(12):2192-8
17190943
J Comput Assist Tomogr. 2001 Sep-Oct;25(5):805-16
11584245
Neurology. 2001 Apr 10;56(7):921-6
11294930
IEEE Trans Med Imaging. 1997 Apr;16(2):187-98
9101328
Stroke. 1996 Aug;27(8):1274-82
8711786
IEEE Trans Med Imaging. 2001 Mar;20(3):193-206
11341709
J Alzheimers Dis. 2003 Oct;5(5):349-55
14646025
IEEE Trans Med Imaging. 2001 Aug;20(8):677-88
11513020
Top Magn Reson Imaging. 2005 Dec;16(6):399-407
17088690