Metabotropic glutamate receptors and dendrodendritic synapses in the main olfactory bulb.
The main olfactory bulb (MOB) is the first site of synaptic processing in the central nervous system for odor information that is relayed from olfactory receptor neurons in the nasal cavity via the olfactory nerve (ON). Glutamate and ionotropic glutamate receptors (iGluRs) play a dominant role at ON synapses. Similarly, glutamate and iGluRs mediate dendrodendritic transmission between several populations of neurons within the MOB network. Neuroanatomical studies demonstrate that metabotropic glutamate receptors (mGluRs) are densely expressed through the MOB network, and they are particularly abundant at dendrodendritic synapses. Until recently, the physiological roles of mGluRs in the MOB were poorly understood. Over the past several years, mGluRs have been shown to play surprisingly powerful neuromodulatory roles at ON synapses and in dendrodendritic neurotransmission in the MOB. This chapter focuses on recent advances in our understanding of mGluR-mediated signaling components at dendrodendritic synapses.
Dong
Hong-Wei
HW
Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA.
Heinbockel
Thomas
T
Hamilton
Kathryn A
KA
Hayar
Abdallah
A
Ennis
Matthew
M
D000818:Animals; D003712:Dendrites / Q000502:physiology*; D006801:Humans; D051379:Mice; D009830:Olfactory Bulb / Q000502:physiology*; D009832:Olfactory Nerve / Q000502:physiology; D018094:Receptors, Metabotropic Glutamate / Q000502:physiology*; D013569:Synapses / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000502:physiology
D018094:Receptors, Metabotropic Glutamate; D005680:gamma-Aminobutyric Acid
Proc Natl Acad Sci U S A. 1995 Apr 11;92(8):3371-5
7724568
Annu Rev Pharmacol Toxicol. 1997;37:205-37
9131252
Nature. 1991 Feb 28;349(6312):760-5
1847995
Neuron. 1998 Apr;20(4):749-61
9581766
J Comp Neurol. 1995 May 8;355(3):455-69
7636025
Brain Res Brain Res Rev. 1999 Jan;29(1):83-120
9974152
Eur J Neurosci. 1998 Feb;10(2):771-6
9749741
J Neurophysiol. 2004 Nov;92(5):3085-96
15212418
Neuron. 2001 Aug 30;31(4):639-51
11545722
J Neurosci. 2005 Sep 7;25(36):8197-208
16148227
Neurosci Res. 1998 Jan;30(1):65-82
9572581
J Neurosci. 2007 May 23;27(21):5664-71
17522311
Neuron. 1999 Jun;23(2):377-84
10399942
Neuroscience. 1995 Nov;69(1):167-76
8637615
J Neurosci. 2000 Mar 1;20(5):2011-21
10684902
J Neurophysiol. 2007 Jan;97(1):858-70
17093122
Mol Pharmacol. 1997 Jan;51(1):119-25
9016353
J Comp Neurol. 1995 Aug 21;359(2):253-71
7499528
Neurosci Lett. 2001 Oct 19;312(2):59-62
11595334
J Neurophysiol. 2001 Mar;85(3):1275-82
11247996
J Neurophysiol. 2007 Jan;97(1):296-306
17035366
Neuron. 2000 Mar;25(3):625-33
10774730
J Neurophysiol. 1999 Jul;82(1):489-94
10400976
J Neurosci. 2004 Jul 28;24(30):6676-85
15282270
J Comp Neurol. 1998 Apr 20;393(4):493-504
9550154
J Neurosci. 1998 Sep 1;18(17):6790-802
9712650
J Comp Neurol. 1998 Apr 13;393(3):332-52
9548554
Neuroscience. 1993 Apr;53(4):1009-18
8389425
J Neurosci. 2007 Jan 3;27(1):132-40
17202480
J Comp Neurol. 1992 Aug 1;322(1):121-35
1430307
Nat Neurosci. 2005 Mar;8(3):354-64
15696160
Semin Cell Dev Biol. 2006 Aug;17(4):411-23
16765614
J Neurophysiol. 2007 Apr;97(4):3136-41
17215500
Nature. 2003 Dec 11;426(6967):623-9
14668854
J Neurophysiol. 2000 Jul;84(1):39-50
10899181
J Neurosci. 2005 Mar 16;25(11):2917-24
15772351
Neuron. 1992 Aug;9(2):259-70
1323311
J Neurophysiol. 1999 Jan;81(1):15-28
9914263
J Neurosci. 2000 Jul 1;20(13):5124-34
10864969
Nat Neurosci. 1999 Dec;2(12):1106-13
10570488
J Neurosci. 2007 May 23;27(21):5654-63
17522310