title: Defining the role of laminin-332 in carcinoma.
abstract: The deadly feature of cancer, metastasis, requires invasion of cells through basement membranes (BM), which normally act as barriers between tissue compartments. In the case of many epithelially-derived cancers (carcinomas), laminin-332 (Ln-332) is a key component of the BM barrier. This review provides a historical examination of Ln-332 from its discovery through identification of its functions in BM and possible role in carcinomas. Current understanding points to distinct roles for the three Ln-332 subunits (alpha3, beta3, gamma2) in cell adhesion, extracellular matrix stability, and cell signaling processes in cancer. Given the large number of studies linking Ln-332 gamma2 subunit with cancer prognosis, particular attention is given to the crucial role of this subunit in cancer invasion and to the unanswered questions in this area.
authors.affiliation: Meharry Medical College, Department of Microbial Pathogenesis & Immune Response; Nashville, TN 37232-6840, USA. vito.quaranta@vanderbilt.edu
authors.forename: Cherise M
authors.initials: CM
authors.lastname: Guess
authors.forename: Vito
authors.initials: V
authors.lastname: Quaranta
mesh_terms: D000818:Animals; D001485:Basement Membrane / Q000378:metabolism; D002277:Carcinoma / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology; D015815:Cell Adhesion Molecules / Q000737:chemistry / Q000502:physiology*; D006801:Humans; D009361:Neoplasm Invasiveness; D000097794:Kalinin
chemical_list: D015815:Cell Adhesion Molecules; D000097794:Kalinin
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