title: Effects of tocotrienol-rich fraction on exercise endurance capacity and oxidative stress in forced swimming rats.
abstract: The present study aimed to examine the effects of tocotrienol-rich fraction (TRF) on exercise endurance and oxidative stress in forced swimming rats. Rats fed on isocaloric diet were orally given 25 (TRF-25) and 50 (TRF-50) mg/kg of TRF, or 25 mg/kg D-alpha-tocopherol (T-25) whilst the control group received only the vehicle for 28 days, followed by being forced to undergo swimming endurance tests, with measurements taken of various biochemical parameters, including blood glucose, lactate and urea nitrogen, glycogen, total antioxidant capacity, antioxidant enzymes, thiobarbituric acid-reactive substances (TBARS), and protein carbonyl. Results showed that the TRF-treated animals (268.0 +/- 24.1 min for TRF-25 and 332.5 +/- 24.3 min for TRF-50) swam significantly longer than the control (135.5 +/- 32.9 min) and T-25-treated (154.1 +/- 36.4 min) animals, whereas there was no difference in the performance between the T-25 and control groups. The TRF-treated rats also showed significantly higher concentrations of liver glycogen, superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx), as well as of muscle glycogen and SOD than the control and the T-25-treated animals, but lower levels in blood lactate, plasma and liver TBARS, and liver and muscle protein carbonyl. Taken together, these results suggest that TRF is able to improve the physiological condition and reduce the exercise-induced oxidative stress in forced swimming rats.
authors.affiliation: Ping Tin Enterprise Co., Ltd., Kaohsiung, Taiwan.
authors.forename: Shu-Ping
authors.initials: SP
authors.lastname: Lee
authors.forename: Guang-Yuan
authors.initials: GY
authors.lastname: Mar
authors.forename: Lean-Teik
authors.initials: LT
authors.lastname: Ng
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D001786:Blood Glucose / Q000032:analysis / Q000187:drug effects; D001806:Blood Urea Nitrogen; D001835:Body Weight / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D019344:Lactic Acid / Q000097:blood; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D000073878:Palm Oil; D010805:Physical Conditioning, Animal / Q000379:methods / Q000502:physiology; D010807:Physical Endurance / Q000187:drug effects*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D010938:Plant Oils / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D013550:Swimming / Q000502:physiology; D024505:Tocopherols / Q000494:pharmacology; D024508:Tocotrienols / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D010936:Plant Extracts; D010938:Plant Oils; D024508:Tocotrienols; D019344:Lactic Acid; D000073878:Palm Oil; D024505:Tocopherols
references.citation: Food Chem Toxicol. 2005 May;43(5):747-53
references.pmid: 15778015
references.citation: Free Radic Biol Med. 1991;10(5):263-75
references.pmid: 1649783
references.citation: Free Radic Biol Med. 2000 Dec;29(11):1106-14
references.pmid: 11121717
references.citation: Lipids. 1995 Dec;30(12):1171-7
references.pmid: 8614309
references.citation: Int J Biochem Cell Biol. 1995 Sep;27(9):923-31
references.pmid: 7584628
references.citation: Mol Cell Biochem. 1992 Apr;111(1-2):109-15
references.pmid: 1588932
references.citation: Neuropharmacology. 2004 Nov;47(6):904-15
references.pmid: 15527824
references.citation: FEBS Lett. 1985 Jun 17;185(2):262-6
references.pmid: 3996604
references.citation: Science. 1973 Feb 9;179(4073):588-90
references.pmid: 4686466
references.citation: Biochem Pharmacol. 2004 Jan 15;67(2):315-24
references.pmid: 14698044
references.citation: Clin Sci (Lond). 1991 Jun;80(6):611-8
references.pmid: 1647925
references.citation: J Biol Chem. 2000 Apr 28;275(17):13049-55
references.pmid: 10777609
references.citation: J Appl Physiol (1985). 2002 May;92(5):1970-7
references.pmid: 11960947
references.citation: J Physiol. 1998 Jun 1;509 ( Pt 2):565-75
references.pmid: 9575304
references.citation: Basic Clin Pharmacol Toxicol. 2008 Jul;103(1):55-60
references.pmid: 18598299
references.citation: Anal Biochem. 1978 Oct 1;90(1):81-9
references.pmid: 727489
references.citation: Proc Soc Exp Biol Med. 1999 Dec;222(3):283-92
references.pmid: 10601887
references.citation: J Nutr. 1990 Jan;120(1):97-104
references.pmid: 2303916
references.citation: Free Radic Biol Med. 1990;8(1):9-13
references.pmid: 2323584
references.citation: Pharmacol Biochem Behav. 1995 Apr;50(4):635-9
references.pmid: 7617712
references.citation: J Appl Physiol (1985). 1999 Jul;87(1):465-70
references.pmid: 10409609
references.citation: Biochem Mol Biol Int. 1993 May;30(1):159-67
references.pmid: 8358328
references.citation: J Gerontol. 1985 May;40(3):281-6
references.pmid: 3989240
references.citation: J Biol Chem. 1952 Mar;195(1):133-40
references.pmid: 14938361
references.citation: Methods Enzymol. 1990;186:464-78
references.pmid: 1978225
references.citation: Int J Sports Med. 2000 Apr;21(3):154-7
references.pmid: 10834344
references.citation: Int J Sports Med. 1984 Feb;5(1):11-4
references.pmid: 6607896
references.citation: Med Sci Sports Exerc. 2000 Sep;32(9):1576-81
references.pmid: 10994907
references.citation: Free Radic Biol Med. 1999 May;26(9-10):1231-7
references.pmid: 10381194
references.citation: Biochem Med. 1982 Dec;28(3):347-52
references.pmid: 7165745
references.citation: Am J Physiol. 1993 May;264(5 Pt 2):R992-8
references.pmid: 8498608
references.citation: Med Sci Sports Exerc. 2000 Apr;32(4):778-89
references.pmid: 10776897
references.citation: Biochem Biophys Res Commun. 1982 Aug 31;107(4):1198-205
references.pmid: 6291524
references.citation: Biosci Rep. 1984 Mar;4(3):253-7
references.pmid: 6722290
references.citation: J Physiol Biochem. 2007 Sep;63(3):187-94
references.pmid: 18309774
references.citation: Neurosci Lett. 1995 Aug 11;195(3):179-82
references.pmid: 8584204
references.citation: J Appl Physiol (1985). 1997 Jul;83(1):189-95
references.pmid: 9216963
references.citation: J Int Soc Sports Nutr. 2006 Dec 13;3:37-44
references.pmid: 18500971
references.citation: Med Sci Sports Exerc. 2000 Apr;32(4):790-9
references.pmid: 10776898
references.citation: Thromb Res. 2003;111(4-5):267-71
references.pmid: 14693174
references.citation: Acta Physiol Scand. 1983 Jan;117(1):109-13
references.pmid: 6858698
references.citation: Experientia. 1984 Aug 15;40(8):822-3
references.pmid: 6468585
references.citation: Mol Nutr Food Res. 2008 Aug;52(8):921-9
references.pmid: 18481320
references.citation: Med Sci Sports Exerc. 1993 Feb;25(2):225-31
references.pmid: 8450725
references.citation: Comp Biochem Physiol B Biochem Mol Biol. 1998 Apr;119(4):833-6
references.pmid: 9787774
references.citation: Eur J Appl Physiol Occup Physiol. 1998 May;77(6):498-502
references.pmid: 9650733
references.citation: J Biol Chem. 1956 Jun;220(2):583-93
references.pmid: 13331917
references.citation: Int J Cancer. 1994 May 15;57(4):529-31
references.pmid: 8181855
references.citation: Chem Pharm Bull (Tokyo). 1981 Sep;29(9):2610-7
references.pmid: 7349281