title: Enhancing m currents: a way out for neuropathic pain?
abstract: Almost three decades ago, the M current was identified and characterized in frog sympathetic neurons (Brown and Adams, 1980). The years following this discovery have seen a huge progress in the understanding of the function and the pharmacology of this current as well as on the structure of the underlying ion channels. Therapies for a number of syndromes involving abnormal levels of excitability in neurons are benefiting from research on M currents. At present, the potential of M current openers as analgesics for neuropathic pain is under discussion. Here we offer a critical view of existing data on the involvement of M currents in pain processing. We believe that enhancement of M currents at the site of injury may become a powerful strategy to alleviate pain in some peripheral neuropathies.
authors.affiliation: Departamento de Fisiología, Edificio de Medicina, Universidad de Alcala Madrid, Spain.
authors.forename: Ivan
authors.initials: I
authors.lastname: Rivera-Arconada
authors.forename: Carolina
authors.initials: C
authors.lastname: Roza
authors.forename: Jose A
authors.initials: JA
authors.lastname: Lopez-Garcia
references.citation: J Physiol. 2003 May 15;549(Pt 1):57-63
references.pmid: 12702739
references.citation: Mol Pharmacol. 2005 Apr;67(4):1009-17
references.pmid: 15662042
references.citation: Neuroreport. 2002 Apr 16;13(5):585-91
references.pmid: 11973451
references.citation: Pain. 1992 Sep;50(3):355-363
references.pmid: 1333581
references.citation: Nat Rev Neurosci. 2003 Dec;4(12):968-80
references.pmid: 14682359
references.citation: Mol Pain. 2008 Apr 18;4:14
references.pmid: 18419827
references.citation: Pain. 1999 Dec;83(3):389-400
references.pmid: 10568846
references.citation: Naunyn Schmiedebergs Arch Pharmacol. 2004 Apr;369(4):382-90
references.pmid: 15007538
references.citation: Neurology. 2007 Nov 27;69(22):2045-53
references.pmid: 17872363
references.citation: J Neurosci. 2005 May 18;25(20):5051-60
references.pmid: 15901787
references.citation: Curr Top Med Chem. 2006;6(10):999-1023
references.pmid: 16787276
references.citation: J Biol Chem. 2000 Jul 21;275(29):22395-400
references.pmid: 10787416
references.citation: Pharmacol Ther. 2001 Apr;90(1):1-19
references.pmid: 11448722
references.citation: Eur J Neurosci. 2005 Dec;22(12):3091-8
references.pmid: 16367775
references.citation: Nat Rev Neurosci. 2000 Oct;1(1):21-30
references.pmid: 11252765
references.citation: J Physiol. 1981 Sep;318:297-316
references.pmid: 6275068
references.citation: Brain Res. 1986 Feb 19;365(2):369-76
references.pmid: 2418923
references.citation: Curr Opin Neurobiol. 2005 Jun;15(3):370-8
references.pmid: 15922587
references.citation: J Med Chem. 2007 May 31;50(11):2576-82
references.pmid: 17489574
references.citation: Br J Pharmacol. 2000 Feb;129(3):413-5
references.pmid: 10711337
references.citation: Mol Pharmacol. 2000 Sep;58(3):591-600
references.pmid: 10953053
references.citation: J Neurophysiol. 1999 Oct;82(4):1776-85
references.pmid: 10515967
references.citation: J Physiol. 2006 Aug 15;575(Pt 1):175-89
references.pmid: 16777937
references.citation: Eur J Neurosci. 2003 May;17(9):1907-20
references.pmid: 12752790
references.citation: J Neurosci. 2006 Mar 8;26(10):2599-613
references.pmid: 16525039
references.citation: Science. 1988 Jan 15;239(4837):278-80
references.pmid: 2892268
references.citation: Curr Pharm Des. 2005;11(23):2961-76
references.pmid: 16178756
references.citation: Nature. 1980 Feb 14;283(5748):673-6
references.pmid: 6965523
references.citation: Neuron. 2006 Oct 5;52(1):77-92
references.pmid: 17015228
references.citation: Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):13373-8
references.pmid: 11698689
references.citation: J Physiol. 1994 Jun 15;477 ( Pt 3):415-22
references.pmid: 7932231
references.citation: J Neurosci. 2000 Jan 1;20(1):51-8
references.pmid: 10627580
references.citation: J Neurosci. 2006 Sep 6;26(36):9340-8
references.pmid: 16957090
references.citation: Neuron. 2006 Apr 6;50(1):89-100
references.pmid: 16600858
references.citation: Eur J Neurosci. 1997 Mar;9(3):605-16
references.pmid: 9104602
references.citation: Muscle Nerve. 2005 Oct;32(4):459-72
references.pmid: 15973653
references.citation: J Physiol. 2008 Feb 1;586(3):795-802
references.pmid: 18048450
references.citation: Exp Neurol. 2000 Jun;163(2):490-4
references.pmid: 10833324
references.citation: Mol Pharmacol. 2009 Feb;75(2):272-80
references.pmid: 19015229
references.citation: Neuroscience. 1994 Feb;58(3):447-59
references.pmid: 7513385
references.citation: J Comp Neurol. 2007 Dec 1;505(4):363-78
references.pmid: 17912742
references.citation: J Neurosci. 2001 Feb 15;21(4):1096-103
references.pmid: 11160379
references.citation: J Neurosci. 2005 Mar 9;25(10):2576-85
references.pmid: 15758167
references.citation: Neuropharmacology. 2008 Jun;54(8):1271-8
references.pmid: 18474382
references.citation: J Neurosci. 1982 Aug;2(8):1119-28
references.pmid: 6180151
references.citation: Neuropharmacology. 2006 Sep;51(4):756-63
references.pmid: 16844148
references.citation: J Neurosci. 2004 Feb 4;24(5):1236-44
references.pmid: 14762142
references.citation: Brain. 2002 Jun;125(Pt 6):1177-95
references.pmid: 12023309
references.citation: Psychopharmacology (Berl). 2006 Apr;185(2):208-17
references.pmid: 16479373
references.citation: J Pharmacol Exp Ther. 1998 Aug;286(2):709-17
references.pmid: 9694925
references.citation: Proc Natl Acad Sci U S A. 2001 Oct 9;98(21):12272-7
references.pmid: 11572947
references.citation: J Neurophysiol. 2006 Aug;96(2):535-43
references.pmid: 16394077
references.citation: Prog Neurobiol. 2000 Jun;61(2):169-203
references.pmid: 10704997
references.citation: J Neurophysiol. 1983 Mar;49(3):792-803
references.pmid: 6834099
references.citation: Eur J Pharmacol. 2003 Jan 24;460(2-3):109-16
references.pmid: 12559370
references.citation: Nature. 1996 May 16;381(6579):242-5
references.pmid: 8622767
references.citation: Brain. 2005 Sep;128(Pt 9):2154-63
references.pmid: 15947060
references.citation: J Neurosci. 1993 May;13(5):1976-92
references.pmid: 7683047
references.citation: Mol Pharmacol. 2005 Apr;67(4):1053-66
references.pmid: 15598972
references.citation: Neuropharmacology. 2001 Jun;40(7):888-98
references.pmid: 11378159
references.citation: Pain. 2000 Aug;87(2):149-158
references.pmid: 10924808
references.citation: Mol Pharmacol. 2000 Jun;57(6):1218-23
references.pmid: 10825393
references.citation: Neurosci Lett. 1983 Jan 31;35(1):85-91
references.pmid: 6843894
references.citation: Nature. 1990 Aug 2;346(6283):464-7
references.pmid: 1974033
references.citation: J Physiol. 2000 Feb 1;522 Pt 3:349-55
references.pmid: 10713961
references.citation: J Neurosci. 2007 Apr 18;27(16):4492-6
references.pmid: 17442834
references.citation: Br J Pharmacol. 1989 Oct;98(2):557-73
references.pmid: 2819334
references.citation: Br J Pharmacol. 1995 Aug;115(7):1163-8
references.pmid: 7582539
references.citation: Mol Pharmacol. 2000 Aug;58(2):253-62
references.pmid: 10908292
references.citation: Trends Pharmacol Sci. 2008 Feb;29(2):99-107
references.pmid: 18206251
references.citation: J Neurochem. 2009 Apr;109(1):168-81
references.pmid: 19187447
references.citation: Neurosci Lett. 2000 Mar 17;282(1-2):73-6
references.pmid: 10713399
references.citation: Br J Pharmacol. 2009 Apr;156(8):1185-95
references.pmid: 19298256
references.citation: J Pain. 2006 Jan;7(1 Suppl 1):S3-S12
references.pmid: 16426998
references.citation: Trends Neurosci. 1997 Mar;20(3):125-31
references.pmid: 9061867
references.citation: J Physiol. 1982 Nov;332:223-62
references.pmid: 6760380
references.citation: J Neurosci. 2006 Jan 25;26(4):1281-92
references.pmid: 16436616
references.citation: Pain. 2008 Sep 15;138(3):537-545
references.pmid: 18331780
references.citation: J Neurosci. 1994 Feb;14(2):809-20
references.pmid: 7905518
references.citation: Neuron. 2002 Apr 11;34(2):209-20
references.pmid: 11970863
references.citation: J Neurosci. 2008 Apr 2;28(14):3567-76
references.pmid: 18385315
references.citation: Brain. 2003 Mar;126(Pt 3):567-78
references.pmid: 12566278
references.citation: J Neurosci. 2006 Nov 22;26(47):12325-38
references.pmid: 17122058
references.citation: J Pharmacol Exp Ther. 1998 May;285(2):724-30
references.pmid: 9580619
references.citation: J Physiol. 2006 May 15;573(Pt 1):17-34
references.pmid: 16527853
references.citation: Eur J Pharmacol. 2003 Mar 19;464(2-3):95-100
references.pmid: 12620500
references.citation: J Neurosci. 2007 Aug 15;27(33):8914-26
references.pmid: 17699673
references.citation: Eur J Pharmacol. 2001 Oct 19;429(1-3):23-37
references.pmid: 11698024
references.citation: J Physiol. 2007 Aug 1;582(Pt 3):917-25
references.pmid: 17395626
references.citation: J Neurophysiol. 1999 Oct;82(4):1768-75
references.pmid: 10515966
references.citation: Trends Neurosci. 2003 Dec;26(12):696-705
references.pmid: 14624855
references.citation: Q J Exp Physiol. 1989 Nov;74(6):757-84
references.pmid: 2687926
references.citation: Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):7151-6
references.pmid: 9618554
references.citation: Epilepsy Res. 1995 Nov;22(3):167-73
references.pmid: 8991783
references.citation: J Physiol. 2003 Dec 15;553(Pt 3):789-802
references.pmid: 14555721
references.citation: J Neurosci. 2003 Aug 6;23(18):7227-36
references.pmid: 12904483
references.citation: Epilepsy Res. 2009 Jan;83(1):1-43
references.pmid: 19008076
references.citation: J Physiol. 2005 Jul 15;566(Pt 2):519-32
references.pmid: 15878947
references.citation: Science. 1998 Dec 4;282(5395):1890-3
references.pmid: 9836639
references.citation: Neurosci Lett. 1983 Sep 30;40(2):181-6
references.pmid: 6314210
references.citation: Eur J Pharmacol. 2004 Mar 8;487(1-3):93-103
references.pmid: 15033380
references.citation: J Neurosci. 2004 May 12;24(19):4614-24
references.pmid: 15140933
references.citation: Expert Opin Investig Drugs. 2006 Oct;15(10):1167-77
references.pmid: 16989594
references.citation: Neuropharmacology. 1997 Nov-Dec;36(11-12):1747-53
references.pmid: 9517447
references.citation: J Neurosci. 2004 Jan 21;24(3):592-7
references.pmid: 14736843
references.citation: Neurosci Lett. 2000 Jan 7;278(1-2):61-4
references.pmid: 10643801
references.citation: Science. 1998 Jan 16;279(5349):403-6
references.pmid: 9430594
references.citation: Prog Biophys Mol Biol. 2000;73(2-4):135-66
references.pmid: 10958929
references.citation: Neuropharmacology. 2004 Mar;46(4):598-606
references.pmid: 14975684
references.citation: Neuroscience. 2003;120(2):353-64
references.pmid: 12890507
references.citation: Proc Natl Acad Sci U S A. 1988 Feb;85(3):948-52
references.pmid: 2448787
references.citation: Biophys J. 2003 Apr;84(4):2181-91
references.pmid: 12668427
references.citation: J Pharmacol Exp Ther. 2005 Jul;314(1):282-92
references.pmid: 15814569
references.citation: Eur J Neurosci. 2004 May;19(10):2693-702
references.pmid: 15147303
references.citation: Eur J Pharmacol. 1999 Dec 15;386(2-3):165-71
references.pmid: 10618466
references.citation: J Biol Chem. 2000 Aug 4;275(31):24089-95
references.pmid: 10816588
references.citation: J Neurochem. 2007 Jul;102(1):179-93
references.pmid: 17437547
references.citation: Nat Neurosci. 2005 Jan;8(1):51-60
references.pmid: 15608631
references.citation: Cell. 1999 Feb 5;96(3):437-46
references.pmid: 10025409
references.citation: Brain Res. 2003 Sep 12;984(1-2):84-92
references.pmid: 12932842
references.citation: Nature. 1990 Oct 25;347(6295):765-7
references.pmid: 2172830
references.citation: Mol Pharmacol. 2002 Apr;61(4):921-7
references.pmid: 11901232
references.citation: J Physiol. 2008 Apr 1;586(7):1791-801
references.pmid: 18238816
references.citation: J Physiol. 2002 May 1;540(Pt 3):875-81
references.pmid: 11986376
references.citation: Adv Exp Med Biol. 1995;363:47-56
references.pmid: 7618529
references.citation: Proc Natl Acad Sci U S A. 1989 Oct;86(20):8098-102
references.pmid: 2573061
references.citation: J Biol Chem. 1998 Jul 31;273(31):19419-23
references.pmid: 9677360
references.citation: Pain. 1988 Apr;33(1):87-107
references.pmid: 2837713
references.citation: Nature. 1998 Dec 17;396(6712):687-90
references.pmid: 9872318
references.citation: J Biol Chem. 2002 Aug 9;277(32):28545-53
references.pmid: 12032157
references.citation: Exp Brain Res. 1999 Feb;124(4):395-421
references.pmid: 10090653
references.citation: PLoS One. 2007 Dec 26;2(12):e1332
references.pmid: 18159230
references.citation: Nat Neurosci. 2003 Jun;6(6):564-71
references.pmid: 12754513
references.citation: Arzneimittelforschung. 2000 Dec;50(12):1063-70
references.pmid: 11190770
references.citation: J Neurosci. 2006 Feb 15;26(7):2053-9
references.pmid: 16481438
references.citation: J Gen Physiol. 2008 Jun;131(6):575-87
references.pmid: 18474635
references.citation: FASEB J. 2008 Apr;22(4):1135-43
references.pmid: 17993630
references.citation: J Neurosci. 2008 Oct 29;28(44):11240-9
references.pmid: 18971466
references.citation: Eur J Pharmacol. 2004 Oct 1;500(1-3):203-19
references.pmid: 15464034
references.citation: Proc Natl Acad Sci U S A. 2005 Dec 6;102(49):17828-33
references.pmid: 16319223
references.citation: Pharmacol Rev. 2003 Dec;55(4):583-6
references.pmid: 14657415
references.citation: J Comp Neurol. 2008 Oct 1;510(4):367-77
references.pmid: 18668683
references.citation: Neuron. 1995 Feb;14(2):399-405
references.pmid: 7857647
references.citation: J Neurosci. 2005 Aug 10;25(32):7449-58
references.pmid: 16093396