Non-invasive assessment of left ventricular relaxation during atrial fibrillation using mitral flow propagation velocity.
OBJECTIVE
To elucidate the usefulness of the early diastolic mitral flow propagation velocity (V(p)) obtained from colour M-mode Doppler for non-invasively assessing left-ventricular (LV) relaxation during atrial fibrillation (AF).


RESULTS
Ten healthy adult dogs were studied to correlate V(p) with the invasive minimum value of the first derivative of LV pressure decay (dP/dt(min)) and the time constant of isovolumic LV pressure decay (tau) at baseline, during rapid and slow AF, and during AF after inducing myocardial infarction. There were significant positive and negative curvilinear relationships between V(p) and dP/dt(min) and tau, respectively, during rapid AF. After slowing the ventricular rate, the average value of V(p) increased, while dP/dt(min) increased and tau decreased. After inducing myocardial infarction, the average value of V(p) decreased, while dP/dt(min) decreased and tau increased.


CONCLUSIONS
The non-invasively obtained V(p) evaluates LV relaxation even during AF regardless of ventricular rhythm or the presence of pathological changes.
Asada-Kamiguchi
Junko
J
Section of Cardiovascular Imaging, Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA.
Tabata
Tomotsugu
T
Popovic
Zoran B
ZB
Greenberg
Neil L
NL
Kim
Yong Jin
YJ
Garcia
Mario J
MJ
Wallick
Don W
DW
Mowrey
Kent A
KA
Zhuang
Shaowei
S
Zhang
Youhua
Y
Mazgalev
Todor N
TN
Thomas
James D
JD
Grimm
Richard A
RA
D000818:Animals; D001281:Atrial Fibrillation / Q000000981:diagnostic imaging / Q000503:physiopathology*; D001783:Blood Flow Velocity; D003971:Diastole; D004285:Dogs; D018618:Echocardiography, Doppler, Color; D008943:Mitral Valve / Q000000981:diagnostic imaging / Q000503:physiopathology*; D009126:Muscle Relaxation / Q000502:physiology*; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging / Q000503:physiopathology*; D016277:Ventricular Function, Left / Q000502:physiology*
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