IL-2-inducible T-cell kinase (ITK) finds another (dance) partner...TFII-I.
The signals that regulate T-cell activation have been studied for some time. We know that upon interaction with antigen/MHC complex, the TCR triggers the activation of a number of kinases, including tyrosine and serine/threonine kinases. The Tec family kinase IL-2- inducible T-cell kinase (ITK) plays a role in this response, but the signaling pathways that ITK regulates are less well known. Even less known are the binding partners and substrates of ITK. A paper in this issue of the European Journal of Immunology extends our knowledge on the subject by showing that ITK interacts with the transcriptional regulator TFII-I. The implications of this finding are discussed.
August
Avery
A
Center for Molecular Immunology & Infectious Disease, Department of Veterinary & Biomedical Sciences, The Pennsylvania State University, PA 16802, USA. axa45@psu.edu
D000818:Animals; D006801:Humans; D007376:Interleukin-2 / Q000276:immunology / Q000378:metabolism; D016328:NF-kappa B / Q000276:immunology / Q000378:metabolism; D011505:Protein-Tyrosine Kinases / Q000276:immunology / Q000378:metabolism*; D011948:Receptors, Antigen, T-Cell / Q000276:immunology / Q000378:metabolism*; D015398:Signal Transduction / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D019473:Transcription Factors, TFII / Q000276:immunology / Q000378:metabolism*
D007376:Interleukin-2; D016328:NF-kappa B; D011948:Receptors, Antigen, T-Cell; D019473:Transcription Factors, TFII; D011505:Protein-Tyrosine Kinases; C080813:emt protein-tyrosine kinase
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