title: Bacterial cell division: assembly, maintenance and disassembly of the Z ring.
abstract: Bacterial cell division is orchestrated by a tubulin homologue, FtsZ, which polymerizes to form a ring-like structure that is both a scaffold for the assembly of the bacterial cytokinetic machinery and, at least in part, a source of the energy for constriction. FtsZ assembly is tightly regulated, and a diverse repertoire of accessory proteins contributes to the formation of a functional division machine that is responsive to cell cycle status and environmental stress. In this Review, we describe the interaction of these proteins with FtsZ and discuss recent advances in our understanding of Z ring assembly.
authors.affiliation: Centre for Bacterial Cell Biology, Institute for Cell and Molecular Biosciences, Newcastle University, Medical School, Framlington Place, Newcastle-upon-Tyne, NE2 4HH, UK.
authors.forename: David W
authors.initials: DW
authors.lastname: Adams
authors.forename: Jeff
authors.initials: J
authors.lastname: Errington
mesh_terms: D018407:Bacterial Physiological Phenomena; D001426:Bacterial Proteins / Q000378:metabolism*; D002455:Cell Division; D003598:Cytoskeletal Proteins / Q000378:metabolism*; D008954:Models, Biological; D008958:Models, Molecular; D011485:Protein Binding; D055503:Protein Multimerization
chemical_list: D001426:Bacterial Proteins; D003598:Cytoskeletal Proteins; C071525:FtsZ protein, Bacteria
references.citation: Microbiology (Reading). 2007 Mar;153(Pt 3):814-825
references.pmid: 17322202
references.citation: Genes Dev. 2008 Dec 15;22(24):3475-88
references.pmid: 19141479
references.citation: J Mol Biol. 2007 May 25;369(1):210-21
references.pmid: 17428494
references.citation: Nature. 1992 Sep 17;359(6392):254-6
references.pmid: 1528268
references.citation: Cell. 1995 Feb 10;80(3):367-70
references.pmid: 7859278
references.citation: Curr Biol. 2008 Feb 26;18(4):235-44
references.pmid: 18291654
references.citation: Nat Rev Mol Cell Biol. 2005 Nov;6(11):862-71
references.pmid: 16227976
references.citation: Annu Rev Microbiol. 2003;57:125-54
references.pmid: 14527275
references.citation: Mol Microbiol. 2001 Apr;40(1):115-25
references.pmid: 11298280
references.citation: EMBO J. 1998 Jan 15;17(2):462-9
references.pmid: 9430638
references.citation: Nature. 1981 Apr 30;290(5809):797-9
references.pmid: 7012641
references.citation: J Bacteriol. 2006 Mar;188(5):1680-90
references.pmid: 16484179
references.citation: J Biol Chem. 2001 Apr 13;276(15):11743-53
references.pmid: 11152458
references.citation: Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4197-202
references.pmid: 12634424
references.citation: Nature. 1998 Jan 8;391(6663):199-203
references.pmid: 9428769
references.citation: Genes Dev. 1998 Nov 1;12(21):3419-30
references.pmid: 9808628
references.citation: J Bacteriol. 2003 Jun;185(11):3344-51
references.pmid: 12754232
references.citation: Nat Struct Mol Biol. 2004 Dec;11(12):1243-50
references.pmid: 15558053
references.citation: Proc Natl Acad Sci U S A. 1999 Aug 17;96(17):9642-7
references.pmid: 10449747
references.citation: J Mol Evol. 2004 Jan;58(1):19-29
references.pmid: 14743312
references.citation: Nature. 1991 Nov 14;354(6349):161-4
references.pmid: 1944597
references.citation: Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):2885-90
references.pmid: 9501185
references.citation: Mol Microbiol. 2005 Mar;55(6):1722-34
references.pmid: 15752196
references.citation: Cell. 2007 Jul 27;130(2):335-47
references.pmid: 17662947
references.citation: Genes Dev. 1998 Mar 15;12(6):880-93
references.pmid: 9512521
references.citation: Mol Microbiol. 2005 Feb;55(3):699-711
references.pmid: 15660997
references.citation: Mol Microbiol. 2007 Dec;66(6):1396-415
references.pmid: 17986188
references.citation: Mol Microbiol. 2007 Apr;64(2):487-99
references.pmid: 17493130
references.citation: Mol Microbiol. 1999 Oct;34(1):82-90
references.pmid: 10540287
references.citation: Biopolymers. 2009 May;91(5):340-50
references.pmid: 19137575
references.citation: Cell Motil Cytoskeleton. 1998;40(1):71-86
references.pmid: 9605973
references.citation: J Mol Biol. 2004 Aug 13;341(3):839-52
references.pmid: 15288790
references.citation: Mol Microbiol. 1999 Mar;31(6):1853-61
references.pmid: 10209756
references.citation: Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):14819-24
references.pmid: 10611296
references.citation: J Biol Chem. 2003 Apr 18;278(16):13784-8
references.pmid: 12566454
references.citation: Science. 2008 Dec 12;322(5908):1710-3
references.pmid: 19008417
references.citation: J Bacteriol. 2008 Apr;190(7):2513-26
references.pmid: 18245292
references.citation: J Bacteriol. 2004 Sep;186(17):5775-81
references.pmid: 15317782
references.citation: Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9238-43
references.pmid: 19478069
references.citation: J Biol Chem. 2005 Dec 2;280(48):39709-15
references.pmid: 16174771
references.citation: J Bacteriol. 2001 Sep;183(18):5449-52
references.pmid: 11514533
references.citation: EMBO J. 2000 Jul 3;19(13):3179-91
references.pmid: 10880432
references.citation: Genes Dev. 2002 Oct 1;16(19):2544-56
references.pmid: 12368265
references.citation: J Bacteriol. 2003 Oct;185(20):6209-14
references.pmid: 14526035
references.citation: Biochemistry. 2000 Aug 8;39(31):9146-56
references.pmid: 10924108
references.citation: Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6314-9
references.pmid: 8692812
references.citation: J Bacteriol. 2005 Sep;187(18):6536-44
references.pmid: 16159787
references.citation: Science. 2008 May 9;320(5877):792-4
references.pmid: 18420899
references.citation: FEBS Lett. 2001 Apr 6;494(1-2):34-7
references.pmid: 11297730
references.citation: Mol Microbiol. 2009 Apr;72(2):410-24
references.pmid: 19415799
references.citation: Biochemistry. 2007 Sep 25;46(38):11013-22
references.pmid: 17718511
references.citation: Cell. 2002 Apr 19;109(2):257-66
references.pmid: 12007411
references.citation: EMBO J. 2000 Oct 16;19(20):5300-7
references.pmid: 11032797
references.citation: Mol Microbiol. 2008 May;68(3):588-99
references.pmid: 18284588
references.citation: Cell. 2004 Jun 25;117(7):915-25
references.pmid: 15210112
references.citation: J Bacteriol. 2004 Nov;186(22):7736-44
references.pmid: 15516588
references.citation: J Bacteriol. 1999 Oct;181(20):6419-24
references.pmid: 10515933
references.citation: Science. 2008 Sep 19;321(5896):1673-5
references.pmid: 18801997
references.citation: Mol Microbiol. 2005 Jul;57(1):238-49
references.pmid: 15948963
references.citation: EMBO J. 2002 Feb 15;21(4):685-93
references.pmid: 11847116
references.citation: Mol Microbiol. 2004 Sep;53(5):1359-71
references.pmid: 15387815
references.citation: Cell. 1997 Jan 24;88(2):175-85
references.pmid: 9008158
references.citation: Biochem Biophys Res Commun. 1995 Apr 6;209(1):198-204
references.pmid: 7726836
references.citation: EMBO J. 1994 Oct 17;13(20):4919-25
references.pmid: 7957059
references.citation: EMBO J. 1999 May 4;18(9):2364-71
references.pmid: 10228151
references.citation: Microbiology (Reading). 2006 Apr;152(Pt 4):1129-1141
references.pmid: 16549676
references.citation: J Bacteriol. 2002 May;184(9):2552-6
references.pmid: 11948172
references.citation: Mol Microbiol. 2007 May;64(4):1129-38
references.pmid: 17501933
references.citation: Mol Microbiol. 2008 Feb;67(3):558-69
references.pmid: 18186792
references.citation: Mol Microbiol. 2005 Apr;56(1):126-43
references.pmid: 15773984
references.citation: J Biol Chem. 2005 Jun 10;280(23):22549-54
references.pmid: 15826938
references.citation: J Bacteriol. 2007 Dec;189(24):9001-10
references.pmid: 17873055
references.citation: Proc Natl Acad Sci U S A. 1984 Jul;81(14):4490-4
references.pmid: 6087326
references.citation: Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18942-6
references.pmid: 18987308
references.citation: J Cell Biol. 2000 Mar 20;148(6):1103-5
references.pmid: 10725322
references.citation: Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7889-94
references.pmid: 12808143
references.citation: Biochemistry. 2004 Jan 13;43(1):282-8
references.pmid: 14705956
references.citation: J Bacteriol. 2009 Mar;191(6):1986-91
references.pmid: 19136590
references.citation: Mol Cell. 2005 May 27;18(5):555-64
references.pmid: 15916962
references.citation: Cell. 1997 Nov 28;91(5):685-94
references.pmid: 9393861
references.citation: Mol Microbiol. 2008 Feb;67(3):597-608
references.pmid: 18086211
references.citation: Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):3171-5
references.pmid: 11854462
references.citation: J Bacteriol. 2009 Jul;191(13):4186-94
references.pmid: 19429628
references.citation: Mol Microbiol. 2008 May;68(4):1029-46
references.pmid: 18363795
references.citation: J Bacteriol. 1998 Aug;180(15):3946-53
references.pmid: 9683493
references.citation: FEBS Lett. 2008 Jul 23;582(17):2601-8
references.pmid: 18588879
references.citation: Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8298-303
references.pmid: 12835416
references.citation: Mol Microbiol. 2008 Dec;70(5):1166-79
references.pmid: 18976281
references.citation: J Bacteriol. 2004 Sep;186(17):5926-32
references.pmid: 15317798
references.citation: Biophys J. 2008 Mar 1;94(5):1796-806
references.pmid: 18024502
references.citation: Trends Cell Biol. 1997 Sep;7(9):362-7
references.pmid: 17708981
references.citation: J Bacteriol. 2001 Dec;183(24):7190-7
references.pmid: 11717278
references.citation: J Bacteriol. 2002 Aug;184(15):4313-5
references.pmid: 12107152
references.citation: Biochemistry. 2002 Jan 15;41(2):521-9
references.pmid: 11781090
references.citation: Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):519-23
references.pmid: 8552673
references.citation: Mol Microbiol. 2001 Jul;41(1):83-91
references.pmid: 11454202
references.citation: J Bacteriol. 2000 Sep;182(18):5153-66
references.pmid: 10960100
references.citation: J Bacteriol. 2006 Jan;188(1):19-27
references.pmid: 16352817
references.citation: J Bacteriol. 2003 May;185(9):2826-34
references.pmid: 12700262
references.citation: Nat Rev Microbiol. 2005 Dec;3(12):959-68
references.pmid: 16322744
references.citation: Mol Microbiol. 1996 Oct;22(2):231-7
references.pmid: 8930908
references.citation: Genome Biol. 2008;9(7):229
references.pmid: 18671835
references.citation: J Bacteriol. 2000 Jan;182(1):164-70
references.pmid: 10613876
references.citation: Infect Immun. 2000 Feb;68(2):708-15
references.pmid: 10639437
references.citation: J Bacteriol. 1992 Oct;174(19):6145-51
references.pmid: 1400163
references.citation: J Bacteriol. 1999 Dec;181(24):7531-44
references.pmid: 10601211
references.citation: J Bacteriol. 1992 Apr;174(7):2398-403
references.pmid: 1551857
references.citation: J Bacteriol. 1994 Jan;176(1):130-6
references.pmid: 8282688
references.citation: Proc Natl Acad Sci U S A. 1993 Feb 1;90(3):1053-7
references.pmid: 8430073
references.citation: Mol Microbiol. 2008 Dec;70(6):1556-69
references.pmid: 19019154
references.citation: J Bacteriol. 1999 Jan;181(1):167-76
references.pmid: 9864327
references.citation: Mol Microbiol. 2006 Feb;59(3):989-99
references.pmid: 16420366
references.citation: EMBO J. 2007 Nov 14;26(22):4694-708
references.pmid: 17948052
references.citation: Mol Microbiol. 2004 May;52(3):801-14
references.pmid: 15101985
references.citation: J Bacteriol. 1994 May;176(9):2754-8
references.pmid: 8169229
references.citation: EMBO J. 1999 May 4;18(9):2372-83
references.pmid: 10228152
references.citation: Annu Rev Biochem. 2007;76:539-62
references.pmid: 17328675
references.citation: Nature. 2009 Feb 12;457(7231):849-53
references.pmid: 19212404
references.citation: J Mol Biol. 2007 Nov 9;373(5):1229-42
references.pmid: 17900614
references.citation: Mol Microbiol. 1994 Oct;14(2):243-54
references.pmid: 7830569
references.citation: J Biol Chem. 2004 Nov 19;279(47):48821-9
references.pmid: 15328358
references.citation: J Biol Chem. 2007 May 18;282(20):14891-7
references.pmid: 17043359
references.citation: J Bacteriol. 2004 Apr;186(8):2418-29
references.pmid: 15060045
references.citation: Curr Biol. 2005 Jul 12;15(13):R514-26
references.pmid: 16005287
references.citation: Mol Microbiol. 1997 Jun;24(5):905-15
references.pmid: 9219999
references.citation: Int Rev Cytol. 2006;253:27-94
references.pmid: 17098054
references.citation: Nat Struct Biol. 1998 Jun;5(6):451-8
references.pmid: 9628483
references.citation: Mol Microbiol. 2000 Jul;37(2):410-23
references.pmid: 10931335
references.citation: Proc Natl Acad Sci U S A. 2009 Jan 6;106(1):121-6
references.pmid: 19116281
references.citation: Mol Microbiol. 2005 Mar;55(6):1631-45
references.pmid: 15752189
references.citation: J Bacteriol. 1996 Sep;178(17):5080-5
references.pmid: 8752322
references.citation: Mol Microbiol. 2007 Jun;64(5):1289-305
references.pmid: 17542921
references.citation: J Bacteriol. 2000 Jul;182(14):3965-71
references.pmid: 10869074
references.citation: Genome Res. 2004 Aug;14(8):1447-61
references.pmid: 15289470
references.citation: Biophys J. 2005 Jan;88(1):505-14
references.pmid: 15475583
references.citation: Mol Microbiol. 1999 Jul;33(1):84-96
references.pmid: 10411726
references.citation: Nature. 1998 Jan 8;391(6663):203-6
references.pmid: 9428770
references.citation: Mol Microbiol. 2008 May;68(3):720-35
references.pmid: 18394147
references.citation: J Bacteriol. 2000 Nov;182(22):6366-73
references.pmid: 11053380
references.citation: Mol Microbiol. 1993 Aug;9(3):435-42
references.pmid: 8412693
references.citation: Mol Microbiol. 2006 Jul;61(1):33-45
references.pmid: 16824093
references.citation: J Bacteriol. 1993 Feb;175(4):1118-25
references.pmid: 8432706
references.citation: Nature. 1992 Sep 17;359(6392):251-4
references.pmid: 1528267
references.citation: Science. 2008 May 9;320(5877):789-92
references.pmid: 18467587
references.citation: J Biol Chem. 2001 Apr 13;276(15):11980-7
references.pmid: 11278571
references.citation: Proteins. 2003 Feb 1;50(2):192-206
references.pmid: 12486713
references.citation: Mol Microbiol. 2006 Jun;60(6):1364-80
references.pmid: 16796675
references.citation: J Bacteriol. 2008 Nov;190(21):7096-107
references.pmid: 18776011
references.citation: Microbiol Mol Biol Rev. 2003 Mar;67(1):52-65, table of contents
references.pmid: 12626683
references.citation: Mol Microbiol. 2003 Feb;47(4):1113-22
references.pmid: 12581363
references.citation: Biophys J. 2008 Sep;95(5):2470-86
references.pmid: 18502809
references.citation: Proc Natl Acad Sci U S A. 1994 Jun 21;91(13):5813-7
references.pmid: 8016071
references.citation: Biochem Biophys Res Commun. 2000 Apr 13;270(2):387-92
references.pmid: 10753635
references.citation: Curr Opin Cell Biol. 2001 Feb;13(1):55-60
references.pmid: 11163134
references.citation: Curr Biol. 2004 Jul 13;14(13):1167-73
references.pmid: 15242613