Maintaining immune homeostasis in fly gut.
Like every metazoan species hosting a gut flora, drosophila tolerate commensal microbiota yet remain able to mount an efficient immune response to food-borne pathogens. New findings explain how the quantity of reactive oxygen species in the gut is 'tuned' to microbial burden and how intestinal immune homeostasis is thereby maintained
Leulier
François
F
Royet
Julien
J
D000818:Animals; D023181:Antimicrobial Cationic Peptides / Q000096:biosynthesis; D029721:Drosophila Proteins / Q000502:physiology; D004331:Drosophila melanogaster / Q000276:immunology*; D054642:Dual Specificity Phosphatase 6 / Q000502:physiology; D006706:Homeostasis; D007113:Immunity, Innate; D007422:Intestines / Q000276:immunology / Q000382:microbiology; D019255:NADPH Oxidases / Q000502:physiology; D054799:Phospholipase C beta / Q000502:physiology; D017382:Reactive Oxygen Species / Q000378:metabolism; D048051:p38 Mitogen-Activated Protein Kinases / Q000502:physiology
D023181:Antimicrobial Cationic Peptides; D029721:Drosophila Proteins; D017382:Reactive Oxygen Species; C505384:dual oxidase, Drosophila; D019255:NADPH Oxidases; D048051:p38 Mitogen-Activated Protein Kinases; D054642:Dual Specificity Phosphatase 6; C486844:Mkp3 protein, Drosophila; D054799:Phospholipase C beta
Annu Rev Immunol. 2007;25:697-743
17201680
Science. 2004 Nov 12;306(5699):1186-8
15539604
Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2782-7
19196974
Science. 2008 Feb 8;319(5864):777-82
18218863
PLoS Pathog. 2006 Feb;2(2):e14
16518472
Immunity. 2006 Apr;24(4):463-73
16618604
Immunity. 2009 Apr 17;30(4):521-32
19371715
Cell. 2006 Feb 24;124(4):837-48
16497592
Cell Host Microbe. 2008 May 15;3(5):293-303
18474356
Nat Immunol. 2009 Sep;10(9):949-57
19668222
Cell Host Microbe. 2009 Apr 23;5(4):341-52
19380113
Cell Host Microbe. 2008 Aug 14;4(2):147-58
18692774
Science. 2005 Nov 4;310(5749):847-50
16272120
Dev Cell. 2009 Mar;16(3):386-97
19289084