An antifungal tetrapeptide from the culture of Penicillium canescens.
A new tetrapeptide D-Phe-L-Val-D-Val-L-Tyr (1), along with three known diketopiperazines and pseurotin A, were isolated from the culture of Penicillium canescens, collected from pollen from beehives, in a screening for new antimicrobial products from unexplored sources. The structure of the tetrapeptide, which exhibits antifungal activity comparable with that of the commercial product benomyl against the soybean phytopathogen Fusarium virguliforme, was determined by spectroscopic (2D-NMR, and MS and MS/MS) and chemical methods, and the sequence was confirmed by comparison with authentic synthetic isomeric peptides.
Bertinetti
Brenda V
BV
Departamento de Química Orgánica y UMYMFOR, FCEyN, Universidad de Buenos Aires, Ciudad Universitaria, Buenos Aires, Argentina.
Peña
Nora I
NI
Cabrera
Gabriela M
GM
D000935:Antifungal Agents / Q000302:isolation & purification* / Q000494:pharmacology; D005670:Fusarium / Q000187:drug effects; D019906:Nuclear Magnetic Resonance, Biomolecular; D009842:Oligopeptides / Q000302:isolation & purification* / Q000494:pharmacology; D010407:Penicillium / Q000737:chemistry*; D053719:Tandem Mass Spectrometry
D000935:Antifungal Agents; D009842:Oligopeptides; C544753:phenylalanyl-valyl-valyl-tyrosine