Self-assembled Fmoc-peptides as a platform for the formation of nanostructures and hydrogels.
Hydrogels are of great interest as a class of materials for tissue engineering, axonal regeneration, and controlled drug delivery, as they offer 3D interwoven scaffolds to support the growth of cells. Herein, we extend the family of the aromatic Fmoc-dipeptides with a library of new Fmoc-peptides, which include natural and synthetic amino acids with an aromatic nature. We describe the self-assembly of these Fmoc-peptides into various structures and characterize their distinctive molecular and physical properties. Moreover, we describe the fabrication of the bioactive RGD sequence into a hydrogel. This unique material offers new opportunities for developing cell-adhesive biomedical hydrogel scaffolds, as well as for establishing strategies to modify surfaces with bioactive materials.
Orbach
Ron
R
Department of Molecular Microbiology and Biotechnology, George S. Wise Faculty of Life Sciences, Tel-Aviv University, Tel-Aviv 6407536, Israel.
Adler-Abramovich
Lihi
L
Zigerson
Sivan
S
Mironi-Harpaz
Iris
I
Seliktar
Dror
D
Gazit
Ehud
E
D020100:Hydrogels / Q000138:chemical synthesis*; D049329:Nanostructures / Q000737:chemistry*; D009842:Oligopeptides; D019151:Peptide Library; D010455:Peptides / Q000138:chemical synthesis*
D020100:Hydrogels; D009842:Oligopeptides; D019151:Peptide Library; D010455:Peptides; C047981:arginyl-glycyl-aspartic acid