[Study on Luo Han Shen reducing blood glucose diabetic model mice].
OBJECTIVE
to study the function of luo han shen on reducing the blood glucose of the diabetic model mice.


METHODS
124 male Kunming mice (28-32 g) were involved. Alloxan (200 mg/kg) was injected by intraperitoneal injection to establish diabetic model once a day, total two days. The fasting blood glucose of mice were tested 5 days later, greater than 10.0 mmol/L and less than 25 mmol/L as the diabetic model mice. The model mice were divided randomly into four groups based on the fasting blood glucose level(the model control group, the low-dose group, the middle-dose group, the high-dose group), 12 mice each group, given basic diet and diets containing 5%, 10%, 20% luo han shen respectively. 24 normal mice were divided randomly into two groups based on the fasting blood glucose level (the control group and the positive control group), 12 mice each group, given basic diet and diet containing 20% luo han shen respectively. The blood glucose and glucose tolerance were tested 6 weeks later.


RESULTS
After training, the fasting blood glucose level of the high-dose group mice reduced insignificantly (P < 0.05), and was also lower than that of the model control group (P < 0.05). Compared to the model control group and the low-dose group,the blood glucose level at 0, 0.5, 2h and the blood glucose area under the curve of the high-dose group were significantly lower. Compared to the model control, the blood glucose level at 0.5 h of the middle-dose group was significantly lower (P < 0.05). The value of other groups had no significant difference.


CONCLUSIONS
Luo han shen can reduce the blood glucose level and improve the glucose tolerance of diabetic model mice.
Han
Wenting
W
Institute of Nutrition and Food Hygiene, School of Public Health, Shandong University, Jinan 250012, China. babyhan_2003@163.com
Xu
Guifa
G
Liu
Bin
B
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D008517:Phytotherapy; D011897:Random Allocation
D001786:Blood Glucose; D004365:Drugs, Chinese Herbal; D007004:Hypoglycemic Agents