title: Effect of traffic pollution on respiratory and allergic disease in adults: cross-sectional and longitudinal analyses.
abstract: BACKGROUND
  Epidemiological research into the role of traffic pollution on chronic respiratory and allergic disease has focused primarily on children. Studies in adults, in particular those based on objective outcomes such as bronchial hyperresponsiveness, skin sensitisation, and lung function, are limited.
  
  
  METHODS
  We have used an existing cohort of 2644 adults aged 18-70 living in Nottingham, UK, for whom baseline health and demographic data were collected in 1991 and computed two markers of exposure to traffic: distance between the home and nearest main road and modelled outdoor nitrogen dioxide (NO2) concentration at the home location. Using multiple regression techniques, we analysed cross-sectional associations with bronchial hyperresponsiveness, FEV1, spirometry-defined COPD, skin test positivity, total IgE and questionnaire-reported wheeze, asthma, eczema and hayfever in 2599 subjects, and longitudinal associations with decline in FEV1 in 1329 subjects followed-up nine years later in 2000.
  
  
  RESULTS
  There were no significant cross-sectional associations between home proximity to the roadside or NO2 level on any of the outcomes studied (adjusted OR of bronchial hyperresponsiveness in relation to living < or =150 m vs >150 m from a road = 0.92, 95% CI 0.68 to 1.24). Furthermore, neither exposure was associated with a significantly greater decline in FEV1 over time (adjusted mean difference in DeltaFEV1 for living < or =150 m vs >150 m of a road = 10.03 ml, 95% CI, -33.98 to 54.04).
  
  
  CONCLUSIONS
  This study found no evidence to suggest that living in close proximity to traffic is a major determinant of asthma, allergic disease or COPD in adults.
authors.affiliation: Division of Epidemiology and Public Health, University of Nottingham, Nottingham, UK. mar.pujades@epicentre.msf.org
authors.forename: Mar
authors.initials: M
authors.lastname: Pujades-Rodríguez
authors.forename: Tricia
authors.initials: T
authors.lastname: McKeever
authors.forename: Sarah
authors.initials: S
authors.lastname: Lewis
authors.forename: Duncan
authors.initials: D
authors.lastname: Whyatt
authors.forename: John
authors.initials: J
authors.lastname: Britton
authors.forename: Andrea
authors.initials: A
authors.lastname: Venn
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000393:Air Pollutants / Q000009:adverse effects*; D001249:Asthma / Q000453:epidemiology / Q000503:physiopathology; D003430:Cross-Sectional Studies; D005260:Female; D005541:Forced Expiratory Volume / Q000502:physiology; D006801:Humans; D006967:Hypersensitivity / Q000453:epidemiology* / Q000503:physiopathology; D008137:Longitudinal Studies; D008168:Lung / Q000502:physiology; D008171:Lung Diseases / Q000453:epidemiology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive / Q000453:epidemiology / Q000503:physiopathology; D012307:Risk Factors; D006113:United Kingdom; D001335:Vehicle Emissions; D055815:Young Adult
chemical_list: D000393:Air Pollutants; D001335:Vehicle Emissions
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