Gastroprotective effect of dalargin in gastropathy due to treatment with nonsteroid antiinflammatory drugs.
We studied the effect of dalargin and its analogue [Dala]2-leu-enkephalin on the gastric mucosa in indomethacin-receiving animals. Indomethacin treatment was followed by severe injury to the gastric mucosa, decrease in proliferative activity of the epithelium, and stimulation of free-radical processes in gastric tissues. Dalargin significantly decreased the area of erosive and ulcerative lesions, had a normalizing effect on proliferation of epithelial cells, and reduced the degree of oxidative stress. Administration of [Dala]2-leu-enkephalin did not improve the state of the gastric mucosa.
Zhivotova
E Yu
EY
Central Research Laboratory, Far-Eastern State Medical University, Khabarovsk, Russia.
Fleishman
M Yu
MY
Sazonova
E N
EN
Lebed'ko
O A
OA
Timoshin
S S
SS
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D004247:DNA / Q000378:metabolism; D004347:Drug Interactions; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D004847:Epithelial Cells / Q000187:drug effects / Q000502:physiology; D005609:Free Radicals / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects* / Q000293:injuries / Q000503:physiopathology; D005765:Gastrointestinal Agents / Q000494:pharmacology*; D007213:Indomethacin / Q000008:administration & dosage / Q000494:pharmacology*; D049449:Luminescence; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D013276:Stomach Ulcer / Q000188:drug therapy / Q000503:physiopathology; D013997:Time Factors
D000894:Anti-Inflammatory Agents, Non-Steroidal; D005609:Free Radicals; D005765:Gastrointestinal Agents; D016308:Enkephalin, Leucine-2-Alanine; D004247:DNA; C040996:enkephalin-Leu, Ala(2)-Arg(6)-; D007213:Indomethacin