Neural diversity creates a rich repertoire of brain activity.
Despite investigations dating back to the 19(th) century, the functional role of different cell types in the brain remains largely unknown. Using realistic computer simulations, we have recently shown that neural diversity can generate patterns of complex activity that were traditionally interpreted as irreducible noise. Such complex activity may directly contribute to both cognitive and behavioral outcomes, including motor control, perception and memory.
Thivierge
Jean-Philippe
JP
Department of Psychological and Brain Sciences; Indiana University; Bloomington, Indiana USA.
Nat Neurosci. 2008 Nov;11(11):1262-3
18849984
Trends Neurosci. 2007 Jun;30(6):251-9
17462748
Science. 2008 Jul 4;321(5885):53-7
18599766
Neuron. 2001 Jun;30(3):803-17
11430813
Neuron. 1997 Aug;19(2):293-306
9292720
Curr Opin Neurobiol. 2001 Aug;11(4):431-6
11502388
J Neurosci. 2008 Aug 6;28(32):7968-78
18685022
Science. 2004 Apr 23;304(5670):559-64
15105494
Biophys J. 2004 Mar;86(3):1820-8
14990508
Nature. 2004 Jun 17;429(6993):717-23
15170216
Annu Rev Neurosci. 2005;28:357-76
16022600