Behavioral and cellular level changes in the aging somatosensory system.
A study of the peripheral sensory system of young and aged Blk6 mice obtained from the National Institutes on Aging mouse colony is described. Behavioral assays showed male and female aged mice had decreased sensitivity to thermal stimuli. The receptor for the growth factor artemin (Artn), GFRalpha3, and the ion channel TRPV1, which is expressed by 95-99% of GFRalpha3-positive primary sensory neurons, was also decreased. Calcium imaging of isolated dorsal root ganglia neurons grown with nerve growth factor was used to test the in vitro effects of Artn on TRPV1 activation by capsaicin in young and old neurons. Artn potentiated initial TRPV1 responses to capsaicin in young and old neurons, but the percent of capsaicin responders following repeated exposure to capsaicin increased only in young neurons. The lack of change in aged neurons suggests that differences in TRPV1 responses occur with aging in the somatosensory system.
Wang
Shuying
S
Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA.
Albers
Kathryn M
KM
D000375:Aging / Q000378:metabolism / Q000502:physiology*; D000818:Animals; D001519:Behavior; D005260:Female; D051097:Glial Cell Line-Derived Neurotrophic Factor Receptors / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009419:Nerve Tissue Proteins / Q000378:metabolism; D013003:Somatosensory Cortex / Q000166:cytology / Q000378:metabolism / Q000502:physiology*; D050916:TRPV Cation Channels / Q000378:metabolism
C116599:Artn protein, mouse; C494994:Gfra3 protein, mouse; D051097:Glial Cell Line-Derived Neurotrophic Factor Receptors; D009419:Nerve Tissue Proteins; D050916:TRPV Cation Channels; C493921:TRPV1 protein, mouse
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