CD20-positive T-cell large granular lymphocyte leukemia: case report and review of the literature.
CD20-positive T-cell malignancy is a rare disease. We report a case of CD20-positive T-cell large granular lymphocyte leukemia (T-LGLL). The leukemic cells were positive for CD20 and T cell markers, such as CD3, CD4, CD5, CD8 and CD57. A monoclonal rearrangement of the T-cell receptor (TCR) beta chain gene was detected. Twenty-three cases of well-documented CD20-positive T-cell malignancies were reviewed. Most cases were mature T-cell malignancies, especially exhibiting a cytotoxic T-cell phenotype, despite a diversity of the pathological diagnoses. Additional cases must be evaluated to clarify the implications of CD20 expression on T-cell malignancies and to elucidate whether such cases constitute a distinct biologic and clinical disease entity. The accumulation of cases will help to facilitate provision of a proper treatment for CD20-positive T-cell malignancies in the future.
Miyazaki
Koji
K
Department of Hematology, Kitasato University School of Medicine, Sagamihara. miyazakk@med.kitasato-u.ac.jp
Ohsaka
Manabu
M
Suzuki
Yuhko
Y
Danbara
Mikio
M
Horie
Ryouichi
R
Higashihara
Masaaki
M
D000368:Aged; D018951:Antigens, CD20 / Q000096:biosynthesis* / Q000097:blood; D006801:Humans; D054066:Leukemia, Large Granular Lymphocytic / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D008297:Male; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology / Q000473:pathology
D018951:Antigens, CD20