Interaction of copper with iron, iodine, and thyroid hormone status in goitrous patients.
In many developing countries, men and women are at high risk of goiter and iron deficiency. The aim of the recent study is to assess the interaction of (Cu), with iron (Fe), iodine/iodide (I), and thyroid hormones in goitrous patients. Sixty goitrous male (GMPs) and 72 female patients (GFPs) were evaluated for the Cu, Fe, I, and thyroid hormones status in biological samples (serum and urine), and compared to non-goitrous subjects of both genders (M = 106, F = 120). The biological samples were analyzed for Cu and Fe concentration using atomic absorption spectrometer, while I was measured by the potentiometric method, prior to microwave-assisted acid digestion (MD). Quality control for the method was established with certified samples. Significantly higher mean values of Cu in serum, and urine samples of GMPs and GFPs, while lower value of Fe and I were observed as compared to control subjects (p < 0.015), respectively. The mean values of free triiodothyronine (FT3) and free thyroxin (FT4) were found to be lower in goitrous patients of both genders than in the age-matched healthy controls (p < 0.006 and 0.002), respectively, in contrast high mean values of thyroid-stimulating hormone (TSH) were detected in patients (p < 0.009), as compared to non-goitrous subjects. It was observed that the deficiencies of Fe, I, and thyroid hormone in goitrous patients could be influenced by efficiency of Cu.
Kazi
Tasneem Gul
TG
National Centre of Excellence in Analytical Chemistry, Sindh University, Jamshoro, Pakistan. tgkazi@yahoo.com
Kandhro
Ghulam Abbas
GA
Afridi
Hassan Imran
HI
Kazi
Naveed
N
Baig
Jameel Ahmed
JA
Arain
Mohammad Balal
MB
Shah
Abdul Qadir
AQ
Syed
Nasreen
N
Kumar
Sham
S
Kolachi
Nida Fatima
NF
Khan
Sumaira
S
D003300:Copper / Q000378:metabolism*; D003430:Cross-Sectional Studies; D005260:Female; D006042:Goiter / Q000378:metabolism*; D006801:Humans; D007455:Iodine / Q000378:metabolism*; D007501:Iron / Q000378:metabolism*; D008297:Male; D013054:Spectrophotometry, Atomic; D013963:Thyroid Hormones / Q000378:metabolism*
D013963:Thyroid Hormones; D003300:Copper; D007455:Iodine; D007501:Iron