title: Endodermal sinus tumor of the vagina in children: a report of two cases.
abstract: Malignant tumors of the vagina in infants and children are rare, with primary germ cell tumor (endodermal sinus tumor [EST]) being rarer, which carries a dismal prognosis. This tumor is often clinically mistaken as botryoid rhabdomyosarcoma and, on histopathological examination, is often misdiagnosed as clear cell adenocarcinoma. Two cases of EST of the vagina in infants aged 9 and 17 months are reported. Both the patients presented with bleeding per vagina and clinically and by ultrasonography were diagnosed as sarcoma botryoides. Both were diagnosed as primary yolk sac tumors. The serum alfa fetoprotein (AFP) level was 4325 and 9328 ng/ml, respectively. One patient aged 9 months expired 2 months after receiving chemotherapy. The other, aged 17 months, was given chemotherapy followed by surgery with reduction of the AFP levels.
authors.affiliation: Department of Pathology, North Bengal Medical College and Hospital, Sushrutanagar, Darjeeling, India. mimi_ray@rediffmail.com
authors.forename: Mimi
authors.initials: M
authors.lastname: Gangopadhyay
authors.forename: Kalpana
authors.initials: K
authors.lastname: Raha
authors.forename: Swapan K
authors.initials: SK
authors.lastname: Sinha
authors.forename: Anuradha
authors.initials: A
authors.lastname: De
authors.forename: Pranati
authors.initials: P
authors.lastname: Bera
authors.forename: Shyamapada
authors.initials: S
authors.lastname: Pati
mesh_terms: D018240:Endodermal Sinus Tumor / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D017809:Fatal Outcome; D005260:Female; D006470:Hemorrhage / Q000209:etiology; D006651:Histocytochemistry; D006801:Humans; D007223:Infant; D016896:Treatment Outcome; D014621:Vagina / Q000473:pathology; D014625:Vaginal Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D000509:alpha-Fetoproteins