title: A case of epidermolysis bullosa acquisita with clinical features of Brunsting-Perry pemphigoid showing an excellent response to colchicine.
abstract: BACKGROUND
  Brunsting-Perry pemphigoid is a rare subepidermal blistering disease characterized by scarring blisters on the head and neck. However, the identity of the responsible autoantigens is still unresolved.
  
  
  METHODS
  We reported a patient with epidermolysis bullosa acquisita who had clinical features typical of Brunsting-Perry pemphigoid and investigated the involved type VII collagen epitopes. The patient was a 65-year-old Japanese woman with a 20-month history of recurrent subepidermal bullae on her head, face, and neck.
  
  
  RESULTS
  Immunoblot studies revealed that the serum of this patient reacted with type VII collagen, specifically with the noncollagenous domain 1 and the triple-helical domain. The patient responded completely to colchicine monotherapy.
  
  
  CONCLUSIONS
  This study was performed on only one case.
  
  
  CONCLUSIONS
  This study suggests that Brunsting-Perry pemphigoid may be a clinical variant of epidermolysis bullosa acquisita.
authors.affiliation: Department of Dermatology at Kurume University School of Medicine, Fukuoka, Japan.
authors.forename: Noriko
authors.initials: N
authors.lastname: Tanaka
authors.forename: Teruki
authors.initials: T
authors.lastname: Dainichi
authors.forename: Bungo
authors.initials: B
authors.lastname: Ohyama
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Yasumoto
authors.forename: Takashi
authors.initials: T
authors.lastname: Oono
authors.forename: Keiji
authors.initials: K
authors.lastname: Iwatsuki
authors.forename: Susanne
authors.initials: S
authors.lastname: Elfert
authors.forename: Anja
authors.initials: A
authors.lastname: Fritsch
authors.forename: Leena
authors.initials: L
authors.lastname: Bruckner-Tuderman
authors.forename: Takashi
authors.initials: T
authors.lastname: Hashimoto
mesh_terms: D000368:Aged; D003078:Colchicine / Q000008:administration & dosage*; D024143:Collagen Type VII / Q000276:immunology; D016107:Epidermolysis Bullosa Acquisita / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology*; D000939:Epitopes / Q000276:immunology; D005260:Female; D006801:Humans; D010391:Pemphigoid, Bullous / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology*; D050257:Tubulin Modulators / Q000008:administration & dosage*
chemical_list: D024143:Collagen Type VII; D000939:Epitopes; D050257:Tubulin Modulators; D003078:Colchicine