Adenylyl cyclase--A-kinase anchoring protein complexes: the next dimension in cAMP signaling.
The formation of multiprotein complexes is a repeated theme in biology ranging from the regulation of the extracellular signal-regulated kinase and cAMP signaling pathways to the formation of postsynaptic density complexes or tight junctions. A-kinase anchoring proteins (AKAPs) are well known for their ability to scaffold protein kinase A and components upstream and downstream of cAMP production, including G protein-coupled receptors, cAMP-dependent Rap-exchange factors, and phosphodiesterases. Specific adenylyl cyclase (AC) isoforms have also been identified as components of AKAP complexes, namely AKAP79, Yotiao, and mAKAP. In this review, we summarize recent evidence for AC-AKAP complexes and requirements for compartmentalization of cAMP signaling. The ability of AKAPs to assemble intricate feedback loops to control spatiotemporal aspects of cAMP signaling adds yet another dimension to the classic cAMP pathway.
Dessauer
Carmen W
CW
Department of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, Houston, TX 77030, USA. carmen.w.dessauer@uth.tmc.edu
D054758:A Kinase Anchor Proteins / Q000737:chemistry* / Q000502:physiology*; D000262:Adenylyl Cyclases / Q000737:chemistry / Q000378:metabolism* / Q000502:physiology; D000818:Animals; D000242:Cyclic AMP / Q000502:physiology*; D006801:Humans; D011485:Protein Binding / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*
D054758:A Kinase Anchor Proteins; D000242:Cyclic AMP; D000262:Adenylyl Cyclases
J Biol Chem. 2005 Jul 29;280(30):28007-14
15923193
Nat Cell Biol. 2005 Nov;7(11):1066-73
16228013
J Neurosci. 2008 May 7;28(19):4904-17
18463244
Circ Res. 2006 Oct 13;99(8):816-28
17038651
J Biol Chem. 1997 Feb 21;272(8):5157-66
9030583
J Biol Chem. 2002 Feb 22;277(8):6025-31
11744699
J Biol Chem. 2006 Aug 18;281(33):23932-44
16762919
Circ Res. 2006 Mar 17;98(5):675-81
16469954
Neuron. 2008 Aug 14;59(3):450-61
18701070
EMBO J. 2007 Nov 28;26(23):4879-90
17972919
Nat Rev Mol Cell Biol. 2004 Dec;5(12):959-70
15573134
Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12557-62
18711127
Circ Res. 2006 Oct 13;99(8):845-52
16973907
Eur J Cell Biol. 2006 Jul;85(7):585-92
16524641
J Mol Biol. 2001 Apr 27;308(2):99-114
11327755
Proc Natl Acad Sci U S A. 2007 Dec 26;104(52):20990-5
18093912
Neurosignals. 2009;17(1):5-22
18948702
Cardiovasc Res. 2006 Jul 1;71(1):69-78
16631628
Annu Rev Pharmacol Toxicol. 2001;41:751-73
11264475
J Cell Sci. 2005 Dec 1;118(Pt 23):5637-46
16306226
J Biol Chem. 2003 Aug 1;278(31):28849-55
12754202
EMBO J. 1998 Apr 15;17(8):2261-72
9545239
J Biol Chem. 2009 Aug 28;284(35):23540-6
19574217
Exp Cell Res. 2005 Feb 15;303(2):388-99
15652351
FASEB J. 2003 Jan;17(1):82-4
12475901
Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):13835-40
18772391
J Biol Chem. 1999 Jan 29;274(5):3055-66
9915845
J Neurosci. 2006 Mar 1;26(9):2391-402
16510716
J Biol Chem. 2003 Jul 4;278(27):24831-6
12709444
J Biol Chem. 1989 Mar 15;264(8):4648-56
2538452
Trends Mol Med. 2006 Jul;12(7):317-23
16809066
Biol Reprod. 2002 Dec;67(6):1653-61
12444038
Circ Res. 2008 Feb 1;102(2):e1-e11
18174462
J Biol Chem. 2003 May 9;278(19):16936-40
12665504
Trends Pharmacol Sci. 2006 Aug;27(8):426-31
16820220
J Biol Chem. 2009 Apr 3;284(14):9140-6
19218243
Nature. 2005 Sep 22;437(7058):574-8
16177794
J Pharmacol Exp Ther. 1995 Sep;274(3):1513-23
7562528
J Mol Biol. 2006 Sep 29;362(4):623-39
16934836
Trends Pharmacol Sci. 1999 May;20(5):205-10
10354616
J Biol Chem. 1982 Mar 25;257(6):3284-90
6277931
Naunyn Schmiedebergs Arch Pharmacol. 2008 Jun;377(4-6):359-69
17934720
J Biol Chem. 1992 Aug 25;267(24):16816-23
1512224
Science. 1999 Jul 2;285(5424):93-6
10390370
Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):14997-5002
11752448
Physiol Rev. 2007 Jul;87(3):965-1010
17615394
J Biol Chem. 2004 Apr 30;279(18):19375-82
14982933
Science. 2001 Jul 6;293(5527):98-101
11441182
Eur J Cell Biol. 2006 Jul;85(7):623-6
16647783
FEBS Lett. 2000 Jun 30;476(1-2):58-61
10878251
Science. 1996 Mar 15;271(5255):1589-92
8599116
Handb Exp Pharmacol. 2008;(186):285-98
18491057
Curr Opin Nephrol Hypertens. 2009 Jan;18(1):50-6
19077689
Circulation. 2008 Jan 1;117(1):61-9
18071070
Pain. 2008 Sep 15;138(3):604-616
18381233
Genes Brain Behav. 2007 Mar;6(2):120-7
17410641
J Biol Chem. 1997 Aug 1;272(31):19401-7
9235939
J Neurosci. 1998 Mar 15;18(6):2017-27
9482789
Cell. 2007 Jul 27;130(2):247-58
17662940
Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):14100-4
9391159
IUBMB Life. 2007 Mar;59(3):163-9
17487687
Eur J Cell Biol. 2006 Jul;85(7):593-602
16460834
J Biol Chem. 2000 Aug 25;275(34):26530-7
10843990
J Cell Sci. 1999 Aug;112 ( Pt 16):2725-36
10413680
J Biol Chem. 1984 Aug 10;259(15):9840-6
6086653
J Vasc Res. 2001 Mar-Apr;38(2):163-75
11316952
Mol Pharmacol. 2006 Nov;70(5):1700-7
16885208
J Recept Signal Transduct Res. 2008;28(1-2):15-28
18437627
Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9986-90
12904575
J Cell Sci. 2006 Jul 1;119(Pt 13):2807-18
16787947
Science. 2002 Jan 18;295(5554):496-9
11799244
Eur J Cell Biol. 2006 Jul;85(7):627-33
16504338
Trends Biochem Sci. 2006 Jun;31(6):316-23
16690317
J Biol Chem. 1995 May 26;270(21):12481-4
7759492
Biochem Soc Trans. 1995 May;23(2):268S
7672294
J Biol Chem. 1983 Sep 10;258(17):10233-9
6309796
J Biol Chem. 2002 Nov 29;277(48):46010-9
12297500
Science. 1988 Aug 12;241(4867):800-6
2841758
J Physiol. 2008 Sep 1;586(17):4155-64
18617570
J Biol Chem. 1996 Nov 8;271(45):28430-8
8910468
Mol Cell. 2006 Sep 15;23(6):925-31
16973443
Cell Signal. 2007 Mar;19(3):481-9
16979872