Time-series analysis for rapid event-related skin conductance responses.
Event-related skin conductance responses (SCRs) are traditionally analysed by comparing the amplitude of individual peaks against a pre-stimulus baseline. Many experimental manipulations in cognitive neuroscience dictate paradigms with short inter trial intervals, precluding accurate baseline estimation for SCR measurements. Here, we present a novel and general approach to SCR analysis, derived from methods used in neuroimaging that estimate responses using a linear convolution model. In effect, the method obviates peak-scoring and makes use of the full SCR. We demonstrate, across three experiments, that the method has face validity in analysing reactions to a loud white noise and emotional pictures, can be generalised to paradigms where the shape of the response function is unknown and can account for parametric trial-by-trial effects. We suggest our approach provides greater flexibility in analysing SCRs than existing methods.
Bach
Dominik R
DR
Wellcome Trust Centre for Neuroimaging, University College London, 12 Queen Square, London WC1N 3BG, United Kingdom. d.bach@fil.ion.ucl.ac.uk
Flandin
Guillaume
G
Friston
Karl J
KJ
Dolan
Raymond J
RJ
D000161:Acoustic Stimulation; D000293:Adolescent; D000328:Adult; D000465:Algorithms; D016477:Artifacts; D003627:Data Interpretation, Statistical; D004594:Electrophysiology / Q000295:instrumentation / Q000379:methods*; D004644:Emotions / Q000502:physiology; D005260:Female; D005712:Galvanic Skin Response / Q000502:physiology*; D006801:Humans; D016014:Linear Models; D008297:Male; D009483:Neuropsychological Tests; D010775:Photic Stimulation; D012815:Signal Processing, Computer-Assisted / Q000295:instrumentation*; D012984:Software; D013997:Time Factors; D055815:Young Adult
Auton Neurosci. 2001 Apr 12;88(1-2):117-26
11474541
Psychophysiology. 1999 Sep;36(5):543-51
10442022
Brain Res Cogn Brain Res. 2004 Sep;21(1):114-23
15325419
Int J Psychophysiol. 2004 Nov;54(3):231-40
15331214
Magn Reson Med. 1998 Jan;39(1):41-52
9438436
Biol Psychiatry. 1999 Jan 1;45(1):127-35
9894584
Int J Psychophysiol. 1993 Nov;15(3):247-53
8119843
J Neurosci Methods. 2005 Jul 15;146(1):116-23
15935228
Int J Psychophysiol. 1997 Feb;25(2):97-109
9101335
J Auton Nerv Syst. 1996 Dec 14;61(3):277-86
8988486