title: Volume indicators and left ventricular mass during aggressive volume management in patients on thrice-weekly hemodialysis.
abstract: OBJECTIVE
  We examined the relationship between various volume indicators, i.e. multifrequency bioelectric impedance analysis (BIA), predialysis serum N-terminus-pro-brain natriuretic peptide (NT[-]pro[-]BNP) levels, and inferior vena cava diameter, and left ventricular mass index (LVMI) at baseline and with rigorous volume management on thrice-weekly hemodialysis.
  
  
  METHODS
  Twenty-two patients on chronic thrice-weekly hemodialysis were followed for 52 weeks. Left ventricular hypertrophy was present in 100% of the cohort at baseline.
  
  
  RESULTS
  There were no significant correlations among volume indicators except for a correlation between extracellular-volume-to-body-mass ratio and collapsibility index (r = 0.476; p = 0.039) at 6 months. There were no correlations between blood pressure and volume indicators. Baseline (but not follow-up) collapsibility index correlated with LVMI (r = 0.506; p = 0.038). In 'lag-time' analyses, there were no correlations between volume indicators at baseline or 6 months and LVMI at subsequent time points. LVMI decreased from 243.6 +/- 83.3 g/m(2) at baseline to 210.6 +/- 62.9 g/m(2) at 6 months (p = 0.104) and further to 203.2 +/- 49.0 g/m(2) at 12 months (p = 0.035).
  
  
  CONCLUSIONS
  (1) Left ventricular hypertrophy was prevalent in hemodialysis patients; (2) BIA, inferior vena cava ultrasound and serum NT-pro-BNP levels yield discordant results for fluid volumes; (3) regression of LVMI could occur with rigorous fluid management, even with thrice-weekly dialysis.
authors.affiliation: Division of Nephrology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA. agoldfar@bidmc.harvard.edu
authors.forename: Alexander S
authors.initials: AS
authors.lastname: Goldfarb-Rumyantzev
authors.forename: Madhukar
authors.initials: M
authors.lastname: Chelamcharla
authors.forename: Bruce E
authors.initials: BE
authors.lastname: Bray
authors.forename: John K
authors.initials: JK
authors.lastname: Leypoldt
authors.forename: Iran
authors.initials: I
authors.lastname: Lavasani
authors.forename: Natalia
authors.initials: N
authors.lastname: Nelson
authors.forename: Tooran
authors.initials: T
authors.lastname: Lavasani
authors.forename: Bradley
authors.initials: B
authors.lastname: Baird
authors.forename: Alfred K
authors.initials: AK
authors.lastname: Cheung
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000175:diagnosis* / Q000209:etiology*; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000534:rehabilitation*; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D011379:Prognosis; D006435:Renal Dialysis / Q000009:adverse effects* / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D016896:Treatment Outcome