title: Early primary breast cancer in the elderly - pattern of presentation and treatment.
abstract: BACKGROUND
  The incidence of primary breast cancer in elderly patients is increasing. However, little is known about their biological profile and most appropriate clinical management, as most studies have been conducted in the younger population. This study aimed to identify a profile of characteristics in elderly women with operable primary breast cancer and investigate the dynamics influencing the treatment decision-making process.
  
  
  METHODS
  A review of 268 consecutive female patients >70 years of age, diagnosed with early operable primary breast cancer (<5 cm) over a 30-month period at the Nottingham Breast Institute, was conducted. Age, co-morbidity, cancer characteristics, treatment offered and undertaken, and reason for patient choice were recorded and analysed.
  
  
  RESULTS
  The median age was 78 (range 70-100) years. In our study, 82% of the patients had one or more co-morbidities, with 34% of them having three or more co-morbidities. The commonest pathological diagnosis (from needle core biopsies) was invasive ductal carcinoma of no special type (76%) with histological grade 2 (64%). Majority of them were oestrogen receptor (ER)-positive (84%) and had a high histochemical (H)-score (83% with H-score >200). Most of the patients (60%) underwent primary surgical management, of which 45.4% received breast-conserving surgery. Among the patients who had breast-conserving surgery, 68% of them received adjuvant radiotherapy. When offered genuine choice in treatment options, most patients chose non-operative treatment. Patients who underwent non-operative treatment were on average seven years older and had significantly more co-morbidities than those who had surgery.
  
  
  CONCLUSIONS
  The elderly population evidently have demographic and cancer characteristics distinct from their younger counterparts, with less patients receiving surgical management. Further work is underway to correlate this with their clinical outcomes and to examine the factors behind the treatment decision-making process.
authors.affiliation: Division of Breast Surgery, City Hospital, Hucknall Road, University of Nottingham, Nottingham NG5 1PB, UK. siau-wei.tang@nottingham.ac.uk
authors.forename: S-W
authors.initials: SW
authors.lastname: Tang
authors.forename: H
authors.initials: H
authors.lastname: Parker
authors.forename: L
authors.initials: L
authors.lastname: Winterbottom
authors.forename: K
authors.initials: K
authors.lastname: Hassell
authors.forename: I O
authors.initials: IO
authors.lastname: Ellis
authors.forename: D A L
authors.initials: DA
authors.lastname: Morgan
authors.forename: K L
authors.initials: KL
authors.lastname: Cheung
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001294:Attitude to Health; D001943:Breast Neoplasms / Q000473:pathology / Q000523:psychology / Q000628:therapy*; D018270:Carcinoma, Ductal, Breast; D002908:Chronic Disease / Q000453:epidemiology; D003131:Combined Modality Therapy / Q000379:methods; D015897:Comorbidity; D003657:Decision Making; D005260:Female; D006801:Humans; D006113:United Kingdom / Q000453:epidemiology