title: Pattern separation and completion in olfaction.
abstract: The nervous system must provide a mechanism for very precise discrimination of differing patterns of activity, yet at the same time, there must be a mechanism for generalization to prevent all experiences from being independent and novel. Pattern separation and completion by cortical circuits contribute to these processes, respectively. Based on theoretical and computational models of the piriform cortex and experimental designs developed for hippocampal spatial memory, we provide evidence for pattern separation and completion in the olfactory system and demonstrate the predictive power of these two processes for behavioral odor perception.
authors.affiliation: Emotional Brain Institute, Nathan Kline Institute for Psychiatric Research, and Child and Adolescent Psychiatry, New York University School of Medicine, Orangeburg, New York 10962, USA. dwilson@nki.rfmh.org
authors.forename: Donald A
authors.initials: DA
authors.lastname: Wilson
mesh_terms: D000818:Animals; D006624:Hippocampus / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D009812:Odorants; D009830:Olfactory Bulb / Q000502:physiology; D012903:Smell / Q000502:physiology*
references.citation: J Neurosci. 2006 Jan 25;26(4):1247-59
references.pmid: 16436612
references.citation: Science. 1999 Oct 22;286(5440):711-5
references.pmid: 10531048
references.citation: Physiol Behav. 2001 Jan;72(1-2):51-63
references.pmid: 11239981
references.citation: Chem Senses. 2001 Jun;26(5):551-76
references.pmid: 11418502
references.citation: Science. 1999 Oct 22;286(5440):723-8
references.pmid: 10531051
references.citation: Neuron. 2001 Nov 20;32(4):723-35
references.pmid: 11719211
references.citation: Cold Spring Harb Symp Quant Biol. 1990;55:599-610
references.pmid: 2132840
references.citation: Behav Neurosci. 2006 Dec;120(6):1337-45
references.pmid: 17201479
references.citation: J Neurosci. 2000 Sep 15;20(18):6974-82
references.pmid: 10995842
references.citation: Neuron. 2004 Nov 18;44(4):581-4
references.pmid: 15541306
references.citation: J Neurophysiol. 1994 Aug;72(2):659-77
references.pmid: 7527075
references.citation: Proc Natl Acad Sci U S A. 1991 Aug 1;88(15):6462-6
references.pmid: 1862075
references.citation: Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):1953-8
references.pmid: 17261800
references.citation: Hippocampus. 1996;6(6):654-65
references.pmid: 9034852
references.citation: J Comp Neurol. 2000 Jul 10;422(4):496-509
references.pmid: 10861522
references.citation: Behav Neurosci. 2000 Feb;114(1):32-41
references.pmid: 10718260
references.citation: Neuron. 2006 Jun 15;50(6):937-49
references.pmid: 16772174
references.citation: Neuron. 1999 Jul;23(3):499-511
references.pmid: 10433262
references.citation: Chem Senses. 2001 Jun;26(5):585-94
references.pmid: 11418504
references.citation: J Neurosci. 2007 Sep 12;27(37):10015-23
references.pmid: 17855616
references.citation: Science. 2004 Aug 27;305(5688):1295-8
references.pmid: 15272123
references.citation: Learn Mem. 2001 Sep-Oct;8(5):279-85
references.pmid: 11584075
references.citation: Neuron. 2006 Feb 2;49(3):357-63
references.pmid: 16446140
references.citation: Philos Trans R Soc Lond B Biol Sci. 1971 Jul 1;262(841):23-81
references.pmid: 4399412
references.citation: Science. 2007 Jul 6;317(5834):94-9
references.pmid: 17556551
references.citation: Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3329-33
references.pmid: 8475076
references.citation: J Agric Food Chem. 2003 Feb 26;51(5):1377-81
references.pmid: 12590484
references.citation: Nat Neurosci. 2008 Dec;11(12):1378-80
references.pmid: 18978781
references.citation: J Neurosci. 2002 Jan 15;22(2):RC201
references.pmid: 11784813
references.citation: Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12506-11
references.pmid: 10535952
references.citation: Curr Opin Neurobiol. 1991 Aug;1(2):209-14
references.pmid: 1821183
references.citation: Brain Res. 1990 Aug 13;525(1):175-9
references.pmid: 1978790
references.citation: J Neurosci. 2004 Jul 21;24(29):6611-20
references.pmid: 15269273
references.citation: Science. 2007 Feb 16;315(5814):961-6
references.pmid: 17303747
references.citation: Science. 2008 Mar 21;319(5870):1640-2
references.pmid: 18356518