Skin fragility syndrome in a cat with cholangiohepatitis and hepatic lipidosis.
A case of acquired skin fragility syndrome associated with hepatic disease in a 9-year-old, spayed female, domestic shorthair cat is described. The cat was admitted to the veterinary hospital of the University of São Paulo (Brazil) with a 6-week history of vomiting, inappetence and weight loss. Remarkable signs were weakness, lethargy and profound jaundice that had been present for 10 days according to the owner. On completion of the physical examination, when the cat was gently manipulated for blood collection the thoracic limb and interscapular skin tore. Liver enzymes and bilirubin levels were all above the normal range. On histological examination of skin and liver, Masson's trichrome stain showed collagen fibre alteration and major hepatocyte abnormalities. Findings were consistent with feline skin fragility syndrome associated with cholangiohepatitis and hepatic lipidosis.
Daniel
Alexandre G T
AG
College of Veterinary Medicine and Animal Sciences, University of São Paulo, São Paulo, Brazil. alegtd@yahoo.com.br
Lucas
Sílvia R R
SR
Júnior
Archivaldo R
AR
Monteiro
Paula R G
PR
Ramos
Daniela
D
Pires
Carolina G
CG
Sinhorini
Idércio L
IL
D000818:Animals; D002371:Cat Diseases / Q000175:diagnosis*; D002415:Cats; D002761:Cholangitis / Q000150:complications / Q000175:diagnosis / Q000662:veterinary*; D017809:Fatal Outcome; D005234:Fatty Liver / Q000150:complications / Q000175:diagnosis / Q000662:veterinary*; D005260:Female; D006520:Hepatitis, Animal / Q000150:complications / Q000175:diagnosis*; D012871:Skin Diseases / Q000175:diagnosis / Q000209:etiology / Q000662:veterinary*; D013577:Syndrome
Res Vet Sci. 1975 Sep;19(2):213-6
1166128
Vet Dermatol. 2007 Oct;18(5):365-9
17845626
Vet Dermatol. 1998 Mar;9(1):49-54
34644957
J Am Vet Med Assoc. 1996 Sep 15;209(6):1114-6
8800259