Functional polymers as therapeutic agents: concept to market place.
Biologically active synthetic polymers have received considerable scientific interest and attention in recent years for their potential as promising novel therapeutic agents to treat human diseases. Although a significant amount of research has been carried out involving polymer-linked drugs as targeted and sustained release drug delivery systems and prodrugs, examples on bioactive polymers that exhibit intrinsic therapeutic properties are relatively less. Several appealing characteristics of synthetic polymers including high molecular weight, molecular architecture, and controlled polydispersity can all be utilized to discover a new generation of therapies. For example, high molecular weight bioactive polymers can be restricted to gastrointestinal tract, where they can selectively recognize, bind, and remove target disease causing substances from the body. The appealing features of GI tract restriction and stability in biological environment render these polymeric drugs to be devoid of systemic toxicity that are generally associated with small molecule systemic drugs. The present article highlights recent developments in the rational design and synthesis of appropriate functional polymers that have resulted in a number of promising polymer based therapies and biomaterials, including some marketed products.
Dhal
Pradeep K
PK
Drug and Biomaterials R&D, Genzyme Corporation, 153 Second Avenue, Waltham, MA 02451, USA. pradeep.dhal@genzyme.com
Polomoscanik
Steven C
SC
Avila
Louis Z
LZ
Holmes-Farley
S Randall
SR
Miller
Robert J
RJ
D000818:Animals; D002986:Clinical Trials as Topic; D016503:Drug Delivery Systems; D015195:Drug Design; D006801:Humans; D008970:Molecular Weight; D011108:Polymers / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use*
D011108:Polymers