title: Delayed effect of hypotensive drugs on blood pressure and structure of the myocardium in hypertensive ISIAH rats during chronic stress.
abstract: Administration of antihypertensive drugs alpha(1)-adrenoceptor antagonist and Ca(2+) channel blocker during early ontogeny had various delayed effects on blood pressure in ISIAH rats with inherited stress-induced arterial hypertension under resting conditions and chronic stress. The drugs did not prevent the development of myocardial hypertrophy. Chronic stress had little effect on myocardial structure in adult animals.
authors.affiliation: Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia. kor@physiol.ru
authors.forename: I M
authors.initials: IM
authors.lastname: Korostyshevskaya
authors.forename: V F
authors.initials: VF
authors.lastname: Maksimov
authors.forename: A L
authors.initials: AL
authors.lastname: Markel
authors.forename: M D
authors.initials: MD
authors.lastname: Shmerling
authors.forename: I I
authors.initials: II
authors.lastname: Buzueva
authors.forename: E E
authors.initials: EE
authors.lastname: Filushina
authors.forename: G S
authors.initials: GS
authors.lastname: Jacobson
mesh_terms: D058668:Adrenergic alpha-1 Receptor Antagonists; D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D002121:Calcium Channel Blockers / Q000494:pharmacology; D006332:Cardiomegaly / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D002908:Chronic Disease; D006321:Heart / Q000187:drug effects*; D008297:Male; D009206:Myocardium / Q000473:pathology*; D051381:Rats; D011919:Rats, Inbred Strains; D013315:Stress, Psychological / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D013997:Time Factors
chemical_list: D058668:Adrenergic alpha-1 Receptor Antagonists; D000317:Adrenergic alpha-Antagonists; D000959:Antihypertensive Agents; D002121:Calcium Channel Blockers