title: Pure choriocarcinoma of ovary diagnosed by fine needle aspiration cytology.
abstract: Pure ovarian choriocarcinoma is extremely rare and can develop as a germ cell tumor or as a metastasis from uterine or tubal gestational choriocarcinoma or rarely from an ovarian pregnancy. The cytomorphologic findings have been reported previously in different sites. However, this is the first case of pure ovarian choriocarcinoma diagnosed on cytology to the best of our knowledge. The distinction between a gestational and nongestational choriocarcinoma is difficult. A 19-year-old female patient presented with an irregular per-vaginal bleeding and a mass in lower abdomen. Fine needle aspiration cytology smears of the mass were hypocellular and showed large, multinucleated giant cells and malignant mononucleated cells. Background was hemorrhagic. Serum beta hCG level was 3,80,000 mIU/ml. A diagnosis of choriocarcinoma was offered which was later confirmed by histopathology. The diagnosis of choriocarcinoma on fine needle aspiration cytology is based on the presence of large, multinucleated giant cells and malignant mononucleated cells. A high index of suspicion should be maintained and estimation of serum beta hCG plays a key role in supporting the diagnosis.
authors.affiliation: Department of Pathology, Krishna Institute of Medical Sciences, Karad, India. manjiri61@gmail.com
authors.forename: M R
authors.initials: MR
authors.lastname: Naniwadekar
authors.forename: S R
authors.initials: SR
authors.lastname: Desai
authors.forename: N S
authors.initials: NS
authors.lastname: Kshirsagar
authors.forename: N N
authors.initials: NN
authors.lastname: Angarkar
authors.forename: V D
authors.initials: VD
authors.lastname: Dombale
authors.forename: S V
authors.initials: SV
authors.lastname: Jagtap
mesh_terms: D044963:Biopsy, Fine-Needle / Q000379:methods*; D002822:Choriocarcinoma / Q000175:diagnosis* / Q000473:pathology*; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood; D005260:Female; D015726:Giant Cells; D006651:Histocytochemistry; D006801:Humans; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D055815:Young Adult
chemical_list: D018997:Chorionic Gonadotropin, beta Subunit, Human