title: Role of serotonin in systemic impairment of motor function of the digestive tract.
abstract: We studied the role of serotonin in systemic impairment of motor function of the digestive tract. Administration of a nitric oxide donor methylene blue into the pre-fundal portion of the stomach and application of a loose ligature to the terminal part of the sigmoid colon were performed after pretreatment with serotonin. Serotonin had a stabilizing effect on esophageal antiperistalsis under conditions of dynamic obstruction of the sigmoid colon.
authors.affiliation: Central Research Institute of Gastroenterology, Moscow, Russia. lychkova@mail.ru
authors.forename: A E
authors.initials: AE
authors.lastname: Lychkova
mesh_terms: D000818:Animals; D012809:Colon, Sigmoid / Q000187:drug effects / Q000503:physiopathology; D003248:Constipation / Q000188:drug therapy / Q000503:physiopathology*; D004576:Electromyography; D004947:Esophagus / Q000187:drug effects / Q000503:physiopathology; D005764:Gastroesophageal Reflux / Q000188:drug therapy / Q000503:physiopathology*; D041981:Gastrointestinal Tract / Q000187:drug effects / Q000503:physiopathology*; D007415:Intestinal Obstruction / Q000188:drug therapy / Q000503:physiopathology; D008751:Methylene Blue / Q000494:pharmacology; D008839:Microelectrodes; D020030:Nitric Oxide Donors / Q000494:pharmacology; D010528:Peristalsis / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000378:metabolism*; D012810:Sigmoid Diseases / Q000188:drug therapy / Q000503:physiopathology; D013270:Stomach / Q000187:drug effects / Q000503:physiopathology
chemical_list: D020030:Nitric Oxide Donors; D012701:Serotonin; D008751:Methylene Blue