title: Role of HPV DNA testing for detection of high-grade cervical lesions in women with atypical squamous cells of undetermined significance: a prospective study in a Korean population.
abstract: OBJECTIVE
  The purpose of this study was to determine if HPV DNA testing improves the accuracy of detecting possible high-grade cervical lesions in women with atypical squamous cells of undetermined significance (ASC-US).
  
  
  METHODS
  Cervical cytology and Hybrid Capture II (HCII) assay for HPV DNA detection was performed in 10,526 women from July 2005 to July 2007. Two hundred and sixty women with ASC-US underwent colposcopy-directed biopsy to determine the final histologic diagnosis. They were divided into two groups according to the positivity of the HPV DNA test, and the respective biopsy results were compared.
  
  
  RESULTS
  Positive HCII was significantly more associated with CIN 2, CIN 3, and invasive cancer than negative HCII (p < 0.001). The odds ratio of positive HPV DNA testing in detecting high-grade lesions was 7.0 (95% CI; 2.8-17.7).
  
  
  CONCLUSIONS
  The HPV DNA test is useful for predicting the severity of lesions of the uterine cervix and formulating decisions with regard to treatment plans.
authors.affiliation: Department of Obstetrics and Gynecology, Ajou University School of Medicine, Suwon, Korea.
authors.forename: J H
authors.initials: JH
authors.lastname: Yoon
authors.forename: S C
authors.initials: SC
authors.lastname: Yoo
authors.forename: W Y
authors.initials: WY
authors.lastname: Kim
authors.forename: S J
authors.initials: SJ
authors.lastname: Chang
authors.forename: K H
authors.initials: KH
authors.lastname: Chang
authors.forename: H S
authors.initials: HS
authors.lastname: Ryu
mesh_terms: D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000821:virology; D003581:Cytodiagnosis; D004279:DNA, Viral / Q000032:analysis*; D005260:Female; D006801:Humans; D008875:Middle Aged; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000175:diagnosis*; D011237:Predictive Value of Tests; D012372:ROC Curve; D012680:Sensitivity and Specificity; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000821:virology; D014626:Vaginal Smears; D002578:Uterine Cervical Dysplasia / Q000175:diagnosis* / Q000821:virology
chemical_list: D004279:DNA, Viral