title: [Immunosuppression in hand transplantation: state of the art and future perspectives].
abstract: Avoidance or minimization of maintenance immunosuppression represents the key step for promoting wider applicability of reconstructive transplantation. Understanding the mechanisms of composite tissue allograft rejection is of essence in working towards this goal. We herein review the current knowledge on acute rejection in reconstructive transplantation and discuss findings in the light of novel immunosuppressive and immunomodulatory strategies.
authors.affiliation: Medizinische Universität Insbruck, Abteilung für Allgemein-, Transplantations- und Thoraxchirurgie, Innsbruck, Austria. robert.sucher@i-med.ac.at
authors.forename: Robert
authors.initials: R
authors.lastname: Sucher
authors.forename: T
authors.initials: T
authors.lastname: Hautz
authors.forename: G
authors.initials: G
authors.lastname: Brandacher
authors.forename: W P Andrew
authors.initials: WP
authors.lastname: Lee
authors.forename: R
authors.initials: R
authors.lastname: Margreiter
authors.forename: S
authors.initials: S
authors.lastname: Schneeberger
mesh_terms: D000328:Adult; D000528:Alternaria; D000935:Antifungal Agents / Q000009:adverse effects / Q000627:therapeutic use; D000998:Antiviral Agents / Q000009:adverse effects / Q000627:therapeutic use; D003586:Cytomegalovirus Infections / Q000188:drug therapy; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005500:Follow-Up Studies; D005544:Forecasting; D006084:Graft Rejection / Q000188:drug therapy*; D063987:Hand Transplantation; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008866:Microsurgery / Q000379:methods*; D008875:Middle Aged; D009181:Mycoses / Q000188:drug therapy; D009894:Opportunistic Infections / Q000188:drug therapy; D012008:Recurrence; D013524:Surgical Flaps; D055815:Young Adult
chemical_list: D000935:Antifungal Agents; D000998:Antiviral Agents; D007166:Immunosuppressive Agents