title: Evaluation of humoral immune response in adaptive immunity in ALS patients during disease progression.
abstract: In ALS, evidence suggests immune reactions in disease pathogenesis. Although immunological changes point to adaptive immune response, whether humoral or cellular response dominates during disease course is unknown. The study aim was to evaluate humoral immune response in ALS patients during disease progression. Circulating immune complexes (CICs), IgG, and IgM in sera of ALS patients and matching controls were evaluated after each of two visits. Results showed significantly elevated CICs and IgG in ALS patient sera. CICs decreased to control levels at the second visit, yet IgG remained higher than controls. Serum IgM was within normal range. Results suggest a humoral immune response initiating adaptive immunity in ALS, however, cellular immune response needs verification.
authors.affiliation: Center of Excellence for Aging and Brain Repair, University of South Florida, College of Medicine, Tampa, FL 33612, USA.
authors.forename: Islam A
authors.initials: IA
authors.lastname: Saleh
authors.forename: Theresa
authors.initials: T
authors.lastname: Zesiewicz
authors.forename: Yong
authors.initials: Y
authors.lastname: Xie
authors.forename: Kelly L
authors.initials: KL
authors.lastname: Sullivan
authors.forename: Amber M
authors.initials: AM
authors.lastname: Miller
authors.forename: Nicole
authors.initials: N
authors.lastname: Kuzmin-Nichols
authors.forename: Paul R
authors.initials: PR
authors.lastname: Sanberg
authors.forename: Svitlana
authors.initials: S
authors.lastname: Garbuzova-Davis
mesh_terms: D000328:Adult; D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000276:immunology* / Q000473:pathology*; D000936:Antigen-Antibody Complex / Q000096:biosynthesis / Q000097:blood; D018450:Disease Progression; D005260:Female; D006801:Humans; D007113:Immunity, Innate; D007074:Immunoglobulin G / Q000096:biosynthesis* / Q000097:blood*; D007075:Immunoglobulin M / Q000096:biosynthesis* / Q000097:blood*; D008297:Male; D008875:Middle Aged
chemical_list: D000936:Antigen-Antibody Complex; D007074:Immunoglobulin G; D007075:Immunoglobulin M