title: Virtual pinhole-scanning spectroscopic imaging platform using low-coherence enhanced backscattering.
abstract: We present that multiple mutually independent coherence areas can be used for simultaneous spatial filtering in an imaging platform as effective as pinhole scanning. In this imaging platform, the unique combination of low-spatial-coherence illumination and differential angle imaging allows us to take advantage of low-coherence enhanced-backscattering (LEBS) phenomenon to permit self-generated optical sectioning to the subsurface in a relatively large area. We further demonstrate that LEBS spectroscopic imaging substantially minimizes cross talk among adjacent pixels, rejects the background light caused by out-of-plane scattered light, and thereby enhances image contrast and resolution.
authors.affiliation: Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana 47907, USA.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Liu
authors.forename: Zhengbin
authors.initials: Z
authors.lastname: Xu
authors.forename: Young L
authors.initials: YL
authors.lastname: Kim
mesh_terms: D006801:Humans; D008027:Light; D057054:Molecular Imaging / Q000295:instrumentation / Q000379:methods*; D009369:Neoplasms; D055620:Optical Phenomena; D019047:Phantoms, Imaging; D012542:Scattering, Radiation; D013057:Spectrum Analysis; D014584:User-Computer Interface