title: Mobilization of progenitor cells into the blood by immobilized granulocytic colony-stimulating factor.
abstract: The effects of granulocytic CSF immobilized on polyethylenoxide by nanotechnology on the bone marrow and circulating pools of mesenchymal and hemopoietic precursors were studied. Immobilized granulocytic CSF caused the release of progenitor cells of different classes into the blood. The effect of injected immobilized granulocytic CSF was superior to that of nonconjugated granulocytic CSF. Specific activity of oral immobilized granulocytic CSF after oral administration was demonstrated.
authors.affiliation: Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk. mmu@pharm.tsu.ru
authors.forename: A M
authors.initials: AM
authors.lastname: Dygai
authors.forename: E I
authors.initials: EI
authors.lastname: Vereshchagin
authors.forename: G N
authors.initials: GN
authors.lastname: Zyuz'kov
authors.forename: V V
authors.initials: VV
authors.lastname: Zhdanov
authors.forename: P G
authors.initials: PG
authors.lastname: Madonov
authors.forename: E V
authors.initials: EV
authors.lastname: Simanina
authors.forename: L A
authors.initials: LA
authors.lastname: Stavrova
authors.forename: E V
authors.initials: EV
authors.lastname: Udut
authors.forename: T Yu
authors.initials: TY
authors.lastname: Khrichkova
authors.forename: L A
authors.initials: LA
authors.lastname: Miroshnichenko
authors.forename: M Yu
authors.initials: MY
authors.lastname: Minakova
authors.forename: N N
authors.initials: NN
authors.lastname: Ermakova
authors.forename: T V
authors.initials: TV
authors.lastname: Firsova
mesh_terms: D000818:Animals; D001790:Blood Physiological Phenomena / Q000187:drug effects*; D001853:Bone Marrow / Q000187:drug effects; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000008:administration & dosage / Q000494:pharmacology*; D006133:Growth Substances / Q000008:administration & dosage / Q000494:pharmacology*; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000502:physiology; D059630:Mesenchymal Stem Cells / Q000187:drug effects / Q000502:physiology; D051379:Mice; D008808:Mice, Inbred CBA; D013234:Stem Cells / Q000187:drug effects* / Q000502:physiology*; D013997:Time Factors
chemical_list: D006133:Growth Substances; D016178:Granulocyte-Macrophage Colony-Stimulating Factor