Cell based vaccination using transplantation of iPSC-derived memory B cells.
The recently developed induced pluripotent stem cell (iPSC) technique provides new direction for vaccination: somatic cells can be induced into iPSCs and expanded, then the cells are genetically or chemically promoted to a immune cell fate, followed with in vitro antigen presenting and processing processes to produce memory B cells that can secret functional antibodies to different pathogens; finally these cells are transplanted back to human.
Li
Jiang
J
Gao
Guo-Dong
GD
Yuan
Ti-Fei
TF
D001402:B-Lymphocytes / Q000276:immunology*; D002454:Cell Differentiation; D006801:Humans; D007156:Immunologic Memory; D039904:Pluripotent Stem Cells / Q000276:immunology*; D033581:Stem Cell Transplantation; D014611:Vaccination / Q000379:methods*