Synergy of BMI and family history on diabetes: the Humboldt Study.
OBJECTIVE
To examine the joint effect of family history and BMI on diabetes.


METHODS
Cross-sectional study.


METHODS
A rural community in Saskatchewan, Canada.


METHODS
The analysis was based on data from 2081 adults, 18-79 years of age, who participated in the Humboldt Study conducted in 2003. Doctor-diagnosed diabetes and family history of diabetes of biological parents and siblings were self-reported. Body weight and height were objectively measured. The interaction of family history and BMI on diabetes was assessed on an additive scale.


RESULTS
The prevalence of diabetes was 7.9 %, and BMI and history of diabetes were two important predictors. The adjusted prevalence ratios were 1.76 (95 % CI 1.37, 2.27) and 2.59 (95 % CI 2.05, 3.31) for those with a BMI of 25.0-29.9 kg/m2 and of at least 30 kg/m2, respectively, compared with a BMI of less than 25 kg/m2, and was 2.41 (95 % CI 2.08, 2.80) for those with a family history of diabetes v. those without. The data indicated an additive interaction of family history and BMI on diabetes.


CONCLUSIONS
When exposed to both family history and overweight/obesity, individuals would have an increased risk that was greater than the sum of their single effects. Reduction of BMI would also reduce the risk of diabetes associated family history.
Chen
Yue
Y
Department of Epidemiology and Community Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada. ychen@uottawa.ca
Rennie
Donna C
DC
Dosman
James A
JA
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000235:genetics* / Q000517:prevention & control; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009765:Obesity; D015995:Prevalence; D012307:Risk Factors; D012424:Rural Population / Q000706:statistics & numerical data; D012525:Saskatchewan / Q000453:epidemiology; D012737:Sex Factors; D012959:Socioeconomic Factors; D011795:Surveys and Questionnaires; D055815:Young Adult