title: Effect of a mangosteen dietary supplement on human immune function: a randomized, double-blind, placebo-controlled trial.
abstract: The effect of a mangosteen product containing multivitamins and essential minerals was tested on immune function and well-being in healthy adults. A randomized, double blinded, placebo-controlled study was conducted in 59 healthy human subjects (40-60 years old). Changes from baseline immune function were measured after a 30-day consumption of the mangosteen product and the placebo. The subjects' self-appraisal of their health status was also surveyed. A xanthone-rich mangosteen product intake increased mean values for peripheral T-helper cell frequency (P = .020) and reduced the serum C-reactive protein concentration (P = .014). Increases in peripheral CD4/CD8 double-positive (DP) T-cell frequency and serum complement C3, C4, and interleukin (IL)-1alpha concentrations were significantly higher in the experimental group than in the placebo group (DP, P = .038; C3, P = .017; C4, P = .031; IL-1alpha, P = .006). At the end of study, serum IL-1alpha and IL-1beta concentrations in the study group were significantly higher than that in the placebo group (IL-1alpha, P = .033; IL-1beta, P = .04). Furthermore, more participants in the experimental group reported greatly improved overall health status compared with participants receiving placebo (P = .001). The results indicated that the intake of an antioxidant-rich product significantly enhanced immune responses and improved the subject's self-appraisal on his or her overall health status.
authors.affiliation: Department of Preventive Medicine, Yanjing Medical School, School of Public Health and Family Medicine, Capital Medical University, Beijing.
authors.forename: Yu-Ping
authors.initials: YP
authors.lastname: Tang
authors.forename: Peng-Gao
authors.initials: PG
authors.lastname: Li
authors.forename: Miwako
authors.initials: M
authors.lastname: Kondo
authors.forename: Hong-Ping
authors.initials: HP
authors.lastname: Ji
authors.forename: Yan
authors.initials: Y
authors.lastname: Kou
authors.forename: Boxin
authors.initials: B
authors.lastname: Ou
mesh_terms: D002097:C-Reactive Protein / Q000378:metabolism; D016516:CD4-CD8 Ratio; D003176:Complement C3 / Q000378:metabolism; D003181:Complement C4 / Q000378:metabolism; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D029762:Garcinia mangostana / Q000737:chemistry; D006304:Health Status; D006801:Humans; D007107:Immune System / Q000187:drug effects*; D053582:Interleukin-1alpha / Q000097:blood; D053583:Interleukin-1beta / Q000097:blood; D008297:Male; D008875:Middle Aged; D028321:Plant Preparations / Q000494:pharmacology*; D006377:T-Lymphocytes, Helper-Inducer / Q000378:metabolism; D044004:Xanthones / Q000494:pharmacology
chemical_list: D003176:Complement C3; D003181:Complement C4; D053582:Interleukin-1alpha; D053583:Interleukin-1beta; D028321:Plant Preparations; D044004:Xanthones; D002097:C-Reactive Protein; C009689:xanthone