title: Successful factor XIII administration for persistent chylothorax after lung transplantation for lymphangioleiomyomatosis.
abstract: Lung transplantation has emerged as a viable treatment option for patients with end-stage lymphangioleiomyomatosis (LAM), and therapeutic outcome results reported thus far have been satisfactory. However, persisting chylothorax after transplantation for LAM remains a challenging problem, and the optimal management has not been decided. We present the case with persistent chylothorax after lung transplantation for LAM, in which the intravenous administration of a tissue repair factor (human factor XIII) resulted in complete resolution of chylous effusion without performing additional invasive treatments, leading to a successful transplant outcome.
authors.affiliation: Department of General Thoracic Surgery, Osaka University Graduate, School of Medicine, Osaka, Japan. shigemura@thoracic.med.osaka-u.ac.jp
authors.forename: Norihisa
authors.initials: N
authors.lastname: Shigemura
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Kawamura
authors.forename: Masato
authors.initials: M
authors.lastname: Minami
authors.forename: Noriyoshi
authors.initials: N
authors.lastname: Sawabata
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Inoue
authors.forename: Tomoki
authors.initials: T
authors.lastname: Utsumi
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Nakagiri
authors.forename: Goro
authors.initials: G
authors.lastname: Matsumiya
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Sawa
authors.forename: Meinoshin
authors.initials: M
authors.lastname: Okumura
mesh_terms: D000328:Adult; D015505:Chest Tubes; D002916:Chylothorax / Q000000981:diagnostic imaging / Q000188:drug therapy*; D005260:Female; D005341:Fibrinolysin / Q000008:administration & dosage*; D006801:Humans; D007275:Injections, Intravenous; D008171:Lung Diseases / Q000000981:diagnostic imaging / Q000601:surgery*; D016040:Lung Transplantation; D018192:Lymphangioleiomyomatosis / Q000000981:diagnostic imaging / Q000601:surgery*; D018700:Pleurodesis; D011183:Postoperative Complications / Q000000981:diagnostic imaging / Q000188:drug therapy*; D011859:Radiography; D013907:Thoracostomy
chemical_list: D005341:Fibrinolysin