title: Golimumab for severe asthma.
abstract: BACKGROUND
  In severe asthma anti-TNF-alpha therapies might be effective in improving disease control based on preclinical results and on clinical short-term data. However, the long-term efficacy and safety is not known.
  
  
  OBJECTIVE
  To discuss the data on golimumab, an anti-TNF-alpha monoclonal antibody currently used in various forms of arthritis, evaluated as an add-on anti-inflammatory therapy in severe asthma.
  
  
  RESULTS
  Critical appraisal of the efficacy and safety clinical data. Golimumab was not found to be generally efficacious and demonstrated an unfavourable risk-benefit ratio, but in some asthma subsets its better therapeutic effects might support its use provided the long-term safety is acceptable.
  
  
  CONCLUSIONS
  Although at first sight the safety and efficacy data of long-term use of golimumab in severe asthma might be unsupportive, in some disease subsets it might be really effective.
authors.affiliation: University of Medicine and Pharmacy Iasi, Pulmonary Disease University Hospital, Department of Internal Medicine-Pulmonary Disease, 30 Dr I Cihac Street, 700115 Iasi, Romania. sabina.antonela.antoniu@pneum.umfiasi.ro
authors.forename: Sabina A
authors.initials: SA
authors.lastname: Antoniu