title: Never-smokers, never-drinkers: unique clinical subgroup of young patients with head and neck squamous cell cancers.
abstract: BACKGROUND
  Young patients represent an increasing subgroup with head and neck cancer.
  
  
  METHODS
  Patients between 18 and 39 years of age with newly diagnosed and previously untreated squamous cell cancers were identified.
  
  
  RESULTS
  Seventy-eight patients met the selection criteria: 28 patients were never-smokers/never-drinkers (NSNDs), and 50 patients reported tobacco or alcohol abuse (smokers and/or drinkers [SD]). NSND patients were diagnosed at a younger median age (31.5 years vs 35.5 years, p = .007), were more likely to be female (75% vs 30%, p < .001) and white (89% vs 60%, p = .006), and were more likely to have tumors of the oral tongue (57% vs 24%, p = .003) and T1 disease (47% vs 20%, p = .01). There was no difference in 10-year relapse-free survival, but a suggestion of improved 10-year overall survival for NSND patients (71% vs 46%, p = .10).
  
  
  CONCLUSIONS
  Young patients with head and neck squamous cell carcinoma (HNSCC) appear to have unique clinical profiles based on history of alcohol and tobacco abuse.
authors.affiliation: Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. slharris@unch.unc.edu
authors.forename: Stephen L
authors.initials: SL
authors.lastname: Harris
authors.forename: Randall J
authors.initials: RJ
authors.lastname: Kimple
authors.forename: D Neil
authors.initials: DN
authors.lastname: Hayes
authors.forename: Marion E
authors.initials: ME
authors.lastname: Couch
authors.forename: Julian G
authors.initials: JG
authors.lastname: Rosenman
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000437:Alcoholism / Q000453:epidemiology; D001707:Biopsy, Needle; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology* / Q000473:pathology* / Q000628:therapy; D015331:Cohort Studies; D003131:Combined Modality Therapy; D005260:Female; D006258:Head and Neck Neoplasms / Q000453:epidemiology* / Q000473:pathology* / Q000628:therapy; D006801:Humans; D007150:Immunohistochemistry; D015994:Incidence; D008297:Male; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology* / Q000473:pathology; D009367:Neoplasm Staging; D011336:Probability; D011379:Prognosis; D012016:Reference Values; D012189:Retrospective Studies; D017678:Sex Distribution; D012907:Smoking / Q000453:epidemiology; D016019:Survival Analysis; D055815:Young Adult
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