Green tea and bone metabolism.
Osteoporosis is a major health problem in both elderly women and men. Epidemiological evidence has shown an association between tea consumption and the prevention of age-related bone loss in elderly women and men. Ingestion of green tea and green tea bioactive compounds may be beneficial in mitigating bone loss of this population and decreasing their risk of osteoporotic fractures. This review describes the effect of green tea or its bioactive components on bone health, with an emphasis on (i) the prevalence and etiology of osteoporosis; (ii) the role of oxidative stress and antioxidants in osteoporosis; (iii) green tea composition and bioavailability; (iv) the effects of green tea and its active components on osteogenesis, osteoblastogenesis, and osteoclastogenesis from human epidemiological, animal, as well as cell culture studies; (v) possible mechanisms explaining the osteoprotective effects of green tea bioactive compounds; (vi) other bioactive components in tea that benefit bone health; and (vii) a summary and future direction of green tea and bone health research and the translational aspects. In general, tea and its bioactive components might decrease the risk of fracture by improving bone mineral density and supporting osteoblastic activities while suppressing osteoclastic activities.
Shen
Chwan-Li
CL
Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, TX 79430-9097, USA. leslie.shen@ttuhsc.edu
Yeh
James K
JK
Cao
Jay J
JJ
Wang
Jia-Sheng
JS
D000368:Aged; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use*; D015519:Bone Density / Q000187:drug effects; D050071:Bone Density Conservation Agents / Q000494:pharmacology / Q000627:therapeutic use*; D016723:Bone Remodeling / Q000187:drug effects; D028241:Camellia sinensis / Q000737:chemistry*; D005260:Female; D050723:Fractures, Bone / Q000517:prevention & control; D006801:Humans; D008297:Male; D010024:Osteoporosis / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D013662:Tea
D000975:Antioxidants; D050071:Bone Density Conservation Agents; D010936:Plant Extracts; D013662:Tea
Biol Pharm Bull. 2003 Apr;26(4):523-6
12673036
Clin J Am Soc Nephrol. 2008 Nov;3 Suppl 3:S131-9
18988698
Semin Arthritis Rheum. 2009 Oct;39(2):132-43
19022481
Biochem Biophys Res Commun. 1984 Dec 14;125(2):441-7
6393977
Am J Clin Nutr. 2001 Mar;73(3):607-12
11237939
Biochem Biophys Res Commun. 2004 Jan 30;314(1):197-207
14715266
J Cell Biochem. 1992 Mar;48(3):277-87
1400614
Biol Trace Elem Res. 1998 Oct;65(1):75-86
9877538
Curr Opin Struct Biol. 2000 Dec;10(6):649-55
11114501
Arch Intern Med. 1997 Mar 24;157(6):629-34
9080917
Osteoporos Int. 2008 Jul;19(7):979-90
18084689
J Cell Sci. 2000 Jul;113 ( Pt 13):2445-53
10852823
Cytokine Growth Factor Rev. 2004 Feb;15(1):49-60
14746813
Cell. 1997 May 30;89(5):747-54
9182762
J Nutr. 1988 Jan;118(1):52-60
3335939
Histol Histopathol. 2004 Jan;19(1):189-99
14702187
Cell Tissue Res. 1999 Nov;298(2):327-34
10571121
J Clin Invest. 1988 Jun;81(6):1804-9
3384952
Anat Rec. 1989 Jun;224(2):317-24
2549811
Biochem Pharmacol. 2001 Nov 1;62(9):1175-83
11705450
Arch Med Res. 2007 Oct;38(7):746-51
17845893
J Int Med Res. 2003 Mar-Apr;31(2):88-101
12760312
Toxicol Appl Pharmacol. 2006 Oct 1;216(1):11-9
16797629
Biochem Pharmacol. 2007 Jan 1;73(1):34-43
17034764
J Bone Miner Res. 1997 Jan;12(1):24-35
9240722
Int Arch Allergy Immunol. 2007;143(1):31-48
17191007
J Periodontal Res. 2007 Jun;42(3):212-8
17451540
J Nutr. 2003 Dec;133(12):4172-7
14652367
J Clin Invest. 2003 Apr;111(8):1221-30
12697741
J Bone Miner Res. 2001 Nov;16(11):2043-9
11697800
J Periodontol. 1993 May;64(5 Suppl):416-31
8315564
J Cell Sci. 2002 Dec 15;115(Pt 24):4809-18
12432069
Biochem Biophys Res Commun. 2002 Mar 22;292(1):94-101
11890677
Eur J Pharmacol. 2008 Jun 10;587(1-3):35-41
18448093
Biochem Cell Biol. 1998;76(6):899-910
10392704
Drug Discov Today. 2002 Jun 15;7(12):653-63
12110242
J Orthop Sci. 2007 Jul;12(4):317-20
17657549
Nature. 2003 May 15;423(6937):356-61
12748655
Free Radic Biol Med. 2001 Mar 1;30(5):456-62
11182517
J Bone Miner Res. 1996 May;11(5):671-5
9157782
J Bone Miner Res. 1995 May;10(5):796-802
7639115
Am J Clin Nutr. 1991 Dec;54(6):1093-100
1659780
Am J Epidemiol. 2003 Oct 15;158(8):772-81
14561667
Am J Clin Nutr. 2000 Apr;71(4):1003-7
10731510
Am J Clin Nutr. 2007 Oct;86(4):1243-7
17921409
Clin Endocrinol (Oxf). 2006 Aug;65(2):234-8
16886966
Dev Dyn. 2006 May;235(5):1390-9
16552759
BMJ. 1996 May 18;312(7041):1254-9
8634613
Biochem Biophys Res Commun. 2005 Mar 18;328(3):728-38
15694407
Best Pract Res Clin Endocrinol Metab. 2008 Oct;22(5):765-85
19028356
J Nutr. 2000 Oct;130(10):2409-12
11015465
J Am Coll Nutr. 2006 Apr;25(2):79-99
16582024
Arthritis Rheum. 2002 Mar;46(3):785-92
11920416
Vitam Horm. 2001;62:1-94
11345896
Endocrinology. 1997 May;138(5):1821-8
9112374
Physiol Rev. 1986 Oct;66(4):855-86
3532144
Nature. 1990 May 31;345(6274):442-4
2188141
Am J Pathol. 2001 Nov;159(5):1689-99
11696430
Biol Pharm Bull. 2001 Dec;24(12):1437-9
11767119
J Biol Chem. 2007 Sep 14;282(37):27285-27297
17623659
Osteoporos Int. 1999;9(1):45-54
10367029
Sci Total Environ. 1993 Sep 30;138(1-3):213-21
8259489
Proc Soc Exp Biol Med. 1999 Apr;220(4):203-9
10202389
Bone. 1998 Jul;23(1):33-41
9662128
Rev Infirm. 1994 Jan;(1):55-62
7652273
Arch Intern Med. 2002 May 13;162(9):1001-6
11996609
Arthritis Res. 2002;4 Suppl 3:S227-32
12110142
J Musculoskelet Neuronal Interact. 2004 Jun;4(2):135-8
15615112
J Clin Invest. 2003 Sep;112(6):915-23
12975476
Curr Opin Rheumatol. 2006 Jul;18(4):419-26
16763464
Biochem Biophys Res Commun. 1985 Dec 17;133(2):483-90
3002346
Mol Pharmacol. 1993 Jul;44(1):37-43
8341277
Endocr Rev. 2005 Oct;26(6):743-74
15901668
Bone. 2009 Apr;44(4):684-90
19118658
Br J Nutr. 1998 Jan;79(1):37-45
9505801
Matrix Biol. 2000 May;19(2):97-105
10842093
J Bone Miner Res. 1995 Nov;10(11):1802-15
8592959
Osteoporos Int. 2009 Jul;20(7):1117-29
19048180
Endocrinology. 1998 Mar;139(3):1338-45
9492070
J Am Coll Nutr. 2000 Apr;19(2):256-61
10763907
Maturitas. 2001 Dec 14;40(3):211-20
11731182
Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3597-602
9520411
Endocrinology. 1988 Sep;123(3):1442-8
3402390
Endocr Rev. 1992 Feb;13(1):66-80
1555533
J Nutr Biochem. 2007 May;18(5):341-7
16963251
Clin Chim Acta. 2002 Apr;318(1-2):145-8
11880125
Ann N Y Acad Sci. 2007 Nov;1116:432-43
17646260
Am J Chin Med. 2004;32(3):361-7
15344419
J Med Microbiol. 2007 Aug;56(Pt 8):1042-1046
17644710
Osteoporos Int. 2008 Mar;19(3):257-68
17701094
Endocrinology. 2008 Jul;149(7):3264-6
18483146
JAMA. 1990 Feb 2;263(5):665-8
2404146
J Biol Chem. 2001 Feb 23;276(8):5452-8
11098048
FEBS Lett. 2007 Apr 3;581(7):1311-6
17350626
J Infect Dis. 2002 Jan 15;185(2):229-36
11807697
Mediators Inflamm. 2008;2008:291808
19148296
J Bone Miner Res. 2007 Mar;22(3):465-75
17144789
J Periodontal Res. 2004 Oct;39(5):300-7
15324350
J Bone Miner Res. 2003 Feb;18(2):312-8
12568408
Wei Sheng Yan Jiu. 2001 Jul;30(4):227-30
12561522
Bone. 2002 Feb;30(2):340-6
11856640
Biochem Biophys Res Commun. 2009 Feb 20;379(4):1033-7
19150340
Endocrinology. 2005 Feb;146(2):728-35
15528306
Best Pract Res Clin Endocrinol Metab. 2008 Oct;22(5):671-85
19028351
EMBO J. 2003 Jun 2;22(11):2546-51
12773371
Biochem Biophys Res Commun. 2000 Apr 21;270(3):793-7
10772904
Ann Nutr Metab. 2005 Mar-Apr;49(2):118-24
15802907
Antioxid Redox Signal. 2004 Jun;6(3):571-82
15130283
J Cell Biol. 1994 Aug;126(3):765-72
8045939
Biochem Biophys Res Commun. 2004 Jan 2;313(1):148-55
14672711
Curr Drug Targets. 2008 Jul;9(7):581-90
18673244
Scand J Rheumatol. 2002;31(5):285-90
12455819
J Exp Med. 2003 May 19;197(10):1303-10
12743173
Epidemiology. 1993 Mar;4(2):128-34
8452901
J Urol. 2005 Jan;173(1):271-5
15592095
J Bone Miner Res. 2001 Jan;16(1):135-40
11149477
JAMA. 1994 Jan 26;271(4):280-3
8295286
Gynecol Endocrinol. 1997 Aug;11(4):289-93
9272427
Trends Cell Biol. 2004 Nov;14(11):628-38
15519852
Biochem Biophys Res Commun. 1998 Apr 7;245(1):101-7
9535791
NIH Consens Statement. 2000 Mar 27-29;17(1):1-45
11525451
Biochem Biophys Res Commun. 1989 Mar 31;159(3):1206-12
2930558
Endocrinology. 1990 Nov;127(5):2592-4
2146111
Curr Pharm Des. 2005;11(23):3039-49
16178762
Arch Biochem Biophys. 2008 May 15;473(2):201-9
18406338
Miner Electrolyte Metab. 1984;10(6):375-8
6334223
Oncogene. 2004 Apr 1;23(14):2507-22
14676829
Lancet. 1993 Oct 23;342(8878):1007-11
8105262
Biometals. 2004 Oct;17(5):493-8
15688852
Cell. 1997 May 30;89(5):755-64
9182763
J Altern Complement Med. 2005 Jun;11(3):521-8
15992239
Can J Physiol Pharmacol. 1996 Aug;74(8):911-7
8960380
J Clin Invest. 2005 Oct;115(10):2665-72
16200200
Osteoporos Int. 2005 Dec;16(12):2039-45
16170444
Stem Cells Dev. 2006 Feb;15(1):118-23
16522169
J Agric Food Chem. 2000 Dec;48(12):6355-61
11312808
Oncogene. 2003 May 22;22(21):3243-51
12761494
Birth Defects Res C Embryo Today. 2005 Sep;75(3):213-25
16187316
J Musculoskelet Neuronal Interact. 2008 Jul-Sep;8(3):204-16
18799853
Toxicol Sci. 2002 Oct;69(2):354-61
12377984
Endocrinology. 1989 Mar;124(3):1424-7
2917519
Ann Pharmacother. 2006 May;40(5):836-49
16670364
Life Sci. 2008 May 7;82(19-20):1012-7
18407296
Prostaglandins Leukot Essent Fatty Acids. 2007 Oct-Nov;77(3-4):173-9
17949962
Am Fam Physician. 2009 Apr 1;79(7):591-4
19378876
J Biol Chem. 2002 Nov 1;277(44):41762-9
12205098
J Steroid Biochem Mol Biol. 2002 Dec;83(1-5):195-7
12650716
Osteoporos Int. 2006;17(7):1055-64
16758142
Curr Med Res Opin. 2008 Jun;24(6):1781-8
18489813
BMC Musculoskelet Disord. 2008 Feb 27;9:28
18304358
Bone. 2001 Mar;28(3):332-6
11248666
Nutr Cancer. 2004;49(2):200-8
15489213
J Nutr. 1998 Dec;128(12):2334-40
9868178
Arthritis Rheum. 2008 Jul;58(7):2012-8
18576345
Food Chem Toxicol. 2008 Jan;46(1):232-40
17888558
Calcif Tissue Int. 1993 Nov;53(5):293-6
8287313
Arch Biochem Biophys. 2009 Mar 1;483(1):99-105
19135025
Am J Physiol. 1989 Nov;257(5 Pt 2):F755-61
2556035
Int J Vitam Nutr Res. 2007 Nov;77(6):389-97
18622949
Semin Cell Dev Biol. 2008 Oct;19(5):467-72
18771742
Horm Metab Res. 2008 Oct;40(10):674-8
18500674
Biochem Pharmacol. 1986 Sep 15;35(18):3091-4
3463305
Curr Drug Discov Technol. 2008 Sep;5(3):263-8
18690894
Cardiovasc Hematol Disord Drug Targets. 2007 Jun;7(2):135-44
17584048
Mayo Clin Proc. 2007 Jun;82(6):719-24
17550752
J Clin Endocrinol Metab. 2003 Apr;88(4):1523-7
12679433
Nat Med. 1999 Jun;5(6):623-8
10371499
Nihon Eiseigaku Zasshi. 1996 Feb;50(6):1084-92
8720935
Endocr Rev. 1999 Jun;20(3):345-57
10368775
J Clin Invest. 1990 Mar;85(3):632-9
2312718
Biochim Biophys Acta. 1984 Nov 6;802(1):151-4
6091772
J Biol Chem. 2003 May 23;278(21):18930-7
12646577
Free Radic Biol Med. 2001 Aug 15;31(4):509-19
11498284
Clin Chem Lab Med. 2008;46(11):1550-5
18847368
Cell Res. 2009 Jan;19(1):71-88
19002158
Proc Soc Exp Biol Med. 1999 Apr;220(4):271-5
10202402
Biochem Biophys Res Commun. 2001 Oct 19;288(1):275-9
11594785