Liver transporters in hepatic drug disposition: an update.
Drug transporters expressed on the hepatocyte membrane play an important role in hepatic drug disposition. In the last two decades, systematic research has resulted in a better understanding of the diversity, expression and substrate specificities of drug transporters in the liver. Here we review recent studies on the role of transporters in drug-drug interactions and disease states such as cirrhosis. We conclude the review by considering techniques and model systems used to study hepatic transporters, including the latest technological developments such as multiphoton microscopy.
Li
Peng
P
University of Queensland, Princess Alexandra Hospital, Brisbane, Australia.
Wang
Guang-Ji
GJ
Robertson
Thomas A
TA
Roberts
Michael S
MS
D000818:Animals; D001692:Biological Transport; D004347:Drug Interactions; D022781:Hepatocytes / Q000378:metabolism; D006801:Humans; D008099:Liver / Q000166:cytology / Q000378:metabolism*; D008107:Liver Diseases / Q000503:physiopathology; D026901:Membrane Transport Proteins / Q000378:metabolism*; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000378:metabolism*
D026901:Membrane Transport Proteins; D004364:Pharmaceutical Preparations