Force induced unfolding of biopolymers in a cellular environment: a model study.
Effect of molecular crowding and confinement experienced by protein in the cell during unfolding has been studied by modeling a linear polymer chain on a percolation cluster. It is known that internal structure of the cell changes in time, however, they do not change significantly from their initial structure. In order to model this we introduce the correlation among the different disorder realizations. It was shown that the force-extension behavior for correlated disorder in both constant force ensemble and constant distance ensemble is significantly different than the one obtained in absence of molecular crowding.
Singh
Amit Raj
AR
Department of Physics, Banaras Hindu University, Varanasi 221 005, India.
Giri
Debaprasad
D
Kumar
Sanjay
S
D001704:Biopolymers / Q000737:chemistry*; D003198:Computer Simulation; D008956:Models, Chemical; D017510:Protein Folding
D001704:Biopolymers