title: Residential proximity to agricultural pesticide applications and childhood acute lymphoblastic leukemia.
abstract: Ambient exposure from residential proximity to applications of agricultural pesticides may contribute to the risk of childhood acute lymphoblastic leukemia (ALL). Using residential histories collected from the families of 213 ALL cases and 268 matched controls enrolled in the Northern California Childhood Leukemia Study, the authors assessed residential proximity within a half-mile (804.5m) of pesticide applications by linking address histories with reports of agricultural pesticide use. Proximity was ascertained during different time windows of exposure, including the first year of life and the child's lifetime through the date of diagnosis for cases or reference for controls. Agricultural pesticides were categorized a priori into groups based on similarities in toxicological effects, physicochemical properties, and target pests or uses. The effects of moderate and high exposure for each group of pesticides were estimated using conditional logistic regression. Elevated ALL risk was associated with lifetime moderate exposure, but not high exposure, to certain physicochemical categories of pesticides, including organophosphates, chlorinated phenols, and triazines, and with pesticides classified as insecticides or fumigants. A similar pattern was also observed for several toxicological groups of pesticides. These findings suggest future directions for the identification of specific pesticides that may play a role in the etiology of childhood leukemia.
authors.affiliation: Northern California Cancer Center, 2001 Center Street, Suite 700, Berkeley, CA 94704, USA. rrull@nccc.org
authors.forename: Rudolph P
authors.initials: RP
authors.lastname: Rull
authors.forename: Robert
authors.initials: R
authors.lastname: Gunier
authors.forename: Julie
authors.initials: J
authors.lastname: Von Behren
authors.forename: Andrew
authors.initials: A
authors.lastname: Hertz
authors.forename: Vonda
authors.initials: V
authors.lastname: Crouse
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Buffler
authors.forename: Peggy
authors.initials: P
authors.lastname: Reynolds
mesh_terms: D002140:California / Q000453:epidemiology; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D004781:Environmental Exposure / Q000009:adverse effects*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D010575:Pesticides / Q000506:poisoning*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000139:chemically induced* / Q000453:epidemiology
chemical_list: D010575:Pesticides
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