Management of arterial hypertension occurring early after living donor liver transplantation in children: report of three cases and review of the literature.
Three pediatric patients with hypertension occurring early after liver transplantation are reviewed. The patients were all female, and underwent living donor liver transplantation at the age of 9 years, 1 month, and 7 months. The etiology of liver disease was cirrhosis due to biliary atresia in two patients and fulminant hepatitis in one patient. Antihypertensive therapy with calcium channel blocker alone was not effective. Blood pressure was eventually controlled after the administration of a beta-adrenergic blocker in addition to the calcium channel blocker to all patients. No end-organ damage was observed, except that two patients developed temporary left ventricular hypertrophy.
Hayashi
Taiyu
T
Division of Pediatric Cardiology, National Center for Child Health and Development, Tokyo, Japan. hayashi-t@ncchd.go.jp
Kato
Hitoshi
H
Kaneko
Masahide
M
Kasahara
Mureo
M
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000367:Age Factors; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D002648:Child; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000209:etiology*; D007223:Infant; D016031:Liver Transplantation / Q000009:adverse effects*; D019520:Living Donors; D013997:Time Factors
D000319:Adrenergic beta-Antagonists; D000959:Antihypertensive Agents; D002121:Calcium Channel Blockers
J Hepatol. 2005 Jan;42(1):68-74
15629509
Pediatrics. 2004 Aug;114(2 Suppl 4th Report):555-76
15286277
Heart. 2000 Jun;83(6):667-72
10814626
Liver Transpl. 2000 Sep;6(5):521-30
10980050
Am J Transplant. 2002 Oct;2(9):807-18
12392286
Am J Transplant. 2005 May;5(5):1111-9
15816894
Pediatrics. 1976 Aug;58(2):259-63
951142
J Pediatr. 1984 Jun;104(6):849-54
6726515
Pediatr Transplant. 2006 May;10(3):316-22
16677355
Transplantation. 2005 Apr 27;79(8):935-40
15849546
Transplantation. 2008 Oct 27;86(8):1028-34
18946339