[Correlation index amylase-creatinine clearance to endogenous creatinine clearance in severe preeclampsia].
BACKGROUND
Tubular lesion may cause acute renal insufficiency in pregnant patients with severe preeclampsia.


OBJECTIVE
To describe the correlation between the amylase/creatinine clearance ratio and endogenous creatinine depuration in pregnant patients with severe preeclampsia.


METHODS
Transversal study (pilot study) twenty eight women with pregnancies of 20 to 40 weeks complicated by severe preeclampsia were studied. Subjects had serum and urine creatinine and amylase determinations to calculate the amylase/creatinine clearance ratio (%). According to the results, two groups were formed: group A (> 3%) and group B (< or = 3%). The correlation between amylase/creatinine clearance ratio and endogenous creatinine depuration was evaluated.


METHODS
measures of central tendency and dispersion, Student's t-test, Pearson correlation coefficient (r) and linear regression were used.


RESULTS
Group A included 23 cases (82%) and group B included 5 cases (18%). Amylase/creatinine clearance ratio (%) for group A was 5.22 +/- 1.6 and for group B was 2.41 +/- 0.41 (p = 0.001). The endogenous creatinine depuration (mL /min. /1.73 m2 SC) for group A was 105.6 +/- 9.71 and for group B was 132.10 +/- 7.95 (p = 0.54). The r between amylase/creatinine clearance ratio and endogenous creatinine depuration for group A was -0.43 and for group B was -0.25.


CONCLUSIONS
A moderately significant negative correlation exists between amylase/creatinine clearance ratio and endogenous creatinine depuration.
Vázquez Rodríguez
Juan Gustavo
JG
Unidad de Cuidados Intensivos de Adultos, Unidad Médica de Alta Especialidad, Hospital de Ginecología y Obstetricia número 3, Centro Médico Nacional La Raza, IMSS, DF México. juangustavovazquez@hotmail.com
Cruz Cruz
Polita del Rocío
Pdel R
Márquez Hubert
Elizabeth
E
D000328:Adult; D000681:Amylases / Q000378:metabolism*; D003404:Creatinine / Q000378:metabolism*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D010865:Pilot Projects; D011225:Pre-Eclampsia / Q000378:metabolism*; D011247:Pregnancy; D012720:Severity of Illness Index
D003404:Creatinine; D000681:Amylases