Combination of 308-nm excimer laser with topical pimecrolimus for the treatment of childhood vitiligo.
Forty-nine patients enrolled in a single-blinded, randomized, comparing 308-nm excimer laser therapy together with topical 1% pimecrolimus cream twice daily (group A) with excimer laser therapy twice per week (group B). Of 48 patients evaluated after 30 weeks of treatment, 71% of patients from group A achieved Grade 3 or 4 repigmentation compared with 50% in group B. Significant difference was found between group A and B at the end of 30 weeks of treatment (p = 0.001).
Hui-Lan
Yang
Y
Department of Dermatology, Liu Hua Qiao Hospital, Guangzhou, China. huilany88@hotmail.com
Xiao-Yan
Huang
H
Jian-Yong
Fan
F
Zong-Rong
Liu
L
D000279:Administration, Cutaneous; D000293:Adolescent; D002648:Child; D003131:Combined Modality Therapy; D003879:Dermatologic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006801:Humans; D054018:Lasers, Excimer / Q000009:adverse effects / Q000627:therapeutic use*; D028022:Low-Level Light Therapy / Q000009:adverse effects; D008297:Male; D016037:Single-Blind Method; D012880:Skin Pigmentation; D016559:Tacrolimus / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D014820:Vitiligo / Q000628:therapy*
D003879:Dermatologic Agents; C117268:pimecrolimus; D016559:Tacrolimus