title: Synthesis of Functionalized Isoindolinones: Addition of In Situ Generated Organoalanes to Acyliminium Ions.
abstract: Addition of in situ generated di- or trisubstituted alkenylalanes to N-acyliminium ions provides rapid access to functionalized isoindolinones. Subsequent ring closing metathesis leads to tricyclic products. These transformations proceed under mild conditions and allow for the convergent synthesis of biologically significant scaffolds from readily available starting materials.
authors.affiliation: Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, U.S.A.
authors.forename: Joshua G
authors.initials: JG
authors.lastname: Pierce
authors.forename: David L
authors.initials: DL
authors.lastname: Waller
authors.forename: Peter
authors.initials: P
authors.lastname: Wipf
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