Quantum dots: a powerful tool for understanding the intricacies of nanoparticle-mediated drug delivery.
Nanoparticle-mediated drug delivery (NMDD) is an emerging research area that seeks to address many of the pharmacokinetic issues encountered with traditional systemically administered drug therapies. Although the field is still in its infancy, recent research has already highlighted the potential for improved drug delivery and targeted therapeutics; however, the real promise lies in combining drug therapy with diagnostic imaging, nucleic acid delivery/gene therapy and/or biosensing applications all in one engineered nanoparticle vector. In this review, the authors discuss the unique contributions that luminescent semiconductor nanocrystals or quantum dots (QDs) offer for NMDD, how they can function as a powerful nanoscale platform to understand this process at its most basic level, and even provide drug-related properties in certain circumstances. Selected examples from the current literature are utilized to describe both their potential and the contributions they have already made towards the design and implementation of NMDD vectors. Important related issues such as QD biofunctionalization and toxicity are also discussed. The paper concludes with a perspective of how this field can be expected to develop in the future.
Delehanty
James B
JB
Center for Bio/Molecular Science and Engineering, SW Washington, DC 20375, USA.
Boeneman
Kelly
K
Bradburne
Christopher E
CE
Robertson
Kelly
K
Medintz
Igor L
IL
D002460:Cell Line; D016503:Drug Delivery Systems; D006801:Humans; D053758:Nanoparticles; D045663:Quantum Dots