Accelerated photo-induced hydrophilicity promotes osseointegration: an animal study.
BACKGROUND
In the previous in vitro study, fluoride-modified, anodized porous titanium was proven to have enhanced its photo-induced hydrophilicity, which induced the hyperactivation of initial cell response.


OBJECTIVE
The purpose of the present study was to investigate in vivo bone apposition during the early stages of osseointegration in rabbit tibiae.


METHODS
Anodized porous titanium implants (TiU, TiUnite®, Nobel Biocare AB, Göteborg, Sweden) were modified with 0.175 wt% ammonium hydrogen fluoride solution (NH(4) F-HF(2) ). Twenty-four hours prior to the experiments, the surface-modified implants were ultraviolet-irradiated (modTiU). Blinded and unpackaged TiU implants were used as controls. Thereafter, the implants were placed in the rabbit tibial metaphyses and histomorphometrically analyzed at 2 and 6 weeks after insertion.


RESULTS
ModTiU demonstrated a significantly greater degree of bone-to-metal contact than TiU after 2 and 6 weeks of healing.


CONCLUSIONS
The results proved that the enhanced photo-induced hydrophilicity of the NH(4) F-HF(2) -modified anodized implants promoted bone apposition during the early stages of osseointegration.
Jimbo
Ryo
R
Division of Regenerative Oral Surgery, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, Japan.
Ono
Daisuke
D
Hirakawa
Yuko
Y
Odatsu
Tetsurou
T
Tanaka
Tsunehiro
T
Sawase
Takashi
T
D000818:Animals; D020099:Coated Materials, Biocompatible / Q000494:pharmacology*; D003722:Dental Alloys / Q000737:chemistry / Q000528:radiation effects; D015921:Dental Implants; D005260:Female; D005460:Fluorides, Topical / Q000494:pharmacology; D005500:Follow-Up Studies; D016348:Osseointegration / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects; D016062:Porosity; D011817:Rabbits; D018709:Statistics, Nonparametric; D013499:Surface Properties / Q000528:radiation effects; D013977:Tibia / Q000502:physiology / Q000528:radiation effects / Q000601:surgery; D014025:Titanium / Q000737:chemistry / Q000528:radiation effects*; D017155:Wettability
D020099:Coated Materials, Biocompatible; D003722:Dental Alloys; D015921:Dental Implants; D005460:Fluorides, Topical; C009495:titanium dioxide; D014025:Titanium