title: Pamidronate treatment in rheumatology practice: a comprehensive review.
abstract: Pamidronate, along with other bisphosphonates, has been used for treatment of bone pain secondary to malignant involvement or metastatic disease for years. Some data, however, have also accumulated on the utility of pamidronate in a variety of benign conditions frequently handled by rheumatologists. This study aims to review the available published data regarding the potential use of pamidronate in rheumatology practice. Methods include the review of relevant articles retrieved by a PUBMED search utilizing the index term "pamidronate". All available randomized control trials, open trials, and case series, as well as properly reported case studies evaluating usage of pamidronate in rheumatic disorders, have been included in the literature review. The efficacy of pamidronate in patients with spondyloarthropathies; synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome; hypertrophic osteoarthropathy; osteoporotic vertebral fractures; chronic back pain due to disk disease or spinal stenosis; Charcot arthropathy; transient osteoporosis; and complex regional pain syndrome-I, has been demonstrated in more than 40 reports, the majority of which, however, were not controlled studies. In some of reviewed conditions, aside from providing analgesic relief, pamidronate may also have disease-modifying properties. While used in different doses in a variety of rheumatic disorders, pamidronate was generally reported to be well tolerated with an overall good safety profile. Pamidronate may represent an effective and safe choice for a spectrum of rheumatic patients, suffering from intractable musculoskeletal pain, unresponsive to traditionally recommended therapies. Large randomized, controlled studies examining the efficacy of pamidronate in the rheumatic conditions are urgently needed.
authors.affiliation: Department of Internal Medicine A, Bnai Zion Medical Center and Ruth & Bruce Rappaport Faculty of Medicine, Technion, 47, Golomb St, Haifa 31048, Israel. gslobodin@yahoo.com
authors.forename: Gleb
authors.initials: G
authors.lastname: Slobodin
authors.forename: Itzhak
authors.initials: I
authors.lastname: Rosner
authors.forename: Joy
authors.initials: J
authors.lastname: Feld
authors.forename: Doron
authors.initials: D
authors.lastname: Rimar
authors.forename: Michael
authors.initials: M
authors.lastname: Rozenbaum
authors.forename: Nina
authors.initials: N
authors.lastname: Boulman
authors.forename: Majed
authors.initials: M
authors.lastname: Odeh
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D004164:Diphosphonates / Q000627:therapeutic use*; D006801:Humans; D010146:Pain / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D000077268:Pamidronate; D039781:PubMed; D016032:Randomized Controlled Trials as Topic; D012216:Rheumatic Diseases / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D012219:Rheumatology / Q000379:methods*
chemical_list: D000893:Anti-Inflammatory Agents; D004164:Diphosphonates; D000077268:Pamidronate
references.citation: Rheumatology (Oxford). 2000 May;39(5):567-8
references.pmid: 10852994
references.citation: Pain Med. 2004 Sep;5(3):276-80
references.pmid: 15367305
references.citation: Rheumatology (Oxford). 2004 May;43(5):658-61
references.pmid: 14983108
references.citation: Blood. 2000 Jul 15;96(2):384-92
references.pmid: 10887096
references.citation: Anticancer Drugs. 2001 Oct;12(9):731-4
references.pmid: 11593054
references.citation: Am J Med Sci. 2008 Feb;335(2):145-8
references.pmid: 18277124
references.citation: J Rheumatol. 1998 Apr;25(4):714-7
references.pmid: 9558174
references.citation: Bone. 2003 Oct;33(4):567-74
references.pmid: 14555260
references.citation: Clin Exp Rheumatol. 2006 May-Jun;24(3):348
references.pmid: 16870109
references.citation: Pain. 1998 Dec;78(3):157-169
references.pmid: 9870569
references.citation: J Obstet Gynaecol Can. 2008 Dec;30(12):1146-1148
references.pmid: 19175968
references.citation: Rheumatology (Oxford). 2002 Oct;41(10):1196-8
references.pmid: 12364646
references.citation: Joint Bone Spine. 2007 Dec;74(6):663-4
references.pmid: 17913553
references.citation: Calcif Tissue Int. 1997 Nov;61(5):386-92
references.pmid: 9351880
references.citation: Clin Rheumatol. 1997 Jan;16(1):51-6
references.pmid: 9132326
references.citation: J Rheumatol. 2001 Jan;28(1):144-55
references.pmid: 11196517
references.citation: Clin Rheumatol. 2009 Jun;28(6):715-7
references.pmid: 19219479
references.citation: Arthritis Rheum. 2002 Mar;46(3):766-73
references.pmid: 11920413
references.citation: Ann Rheum Dis. 2005 Feb;64(2):338-9
references.pmid: 15096328
references.citation: Rheumatology (Oxford). 2002 Feb;41(2):231-3
references.pmid: 11886977
references.citation: J Assoc Physicians India. 2006 Apr;54:340
references.pmid: 16944626
references.citation: Bone. 2002 Jul;31(1):96-101
references.pmid: 12110419
references.citation: J Pain Symptom Manage. 2003 Jul;26(1):678-83
references.pmid: 12850650
references.citation: Clin Rheumatol. 1999;18(3):266-7
references.pmid: 11206358
references.citation: J Pain Symptom Manage. 2002 Sep;24(3):281-4
references.pmid: 12458105
references.citation: Clin Exp Immunol. 2006 Dec;146(3):371-80
references.pmid: 17100755
references.citation: Indian J Dermatol Venereol Leprol. 2005 Jul-Aug;71(4):273-5
references.pmid: 16394439
references.citation: N Engl J Med. 1999 Mar 4;340(9):737-8
references.pmid: 10068336
references.citation: Clin J Pain. 2005 Nov-Dec;21(6):549-52
references.pmid: 16215341
references.citation: Chest. 2002 Apr;121(4):1363-4
references.pmid: 11948079
references.citation: Diabetologia. 2001 Nov;44(11):2032-7
references.pmid: 11719835
references.citation: Ann Rheum Dis. 1995 Aug;54(8):687
references.pmid: 7677451
references.citation: J Rheumatol. 2001 Dec;28(12):2754-7
references.pmid: 11764231
references.citation: Osteoporos Int. 2006;17(11):1659-65
references.pmid: 16896508
references.citation: Rheumatology (Oxford). 2003 Aug;42(8):1018-20
references.pmid: 12869678
references.citation: Joint Bone Spine. 2002 Jun;69(4):392-6
references.pmid: 12184437
references.citation: Rheumatology (Oxford). 2005 Jan;44(1):137; author reply 137-8
references.pmid: 15611315
references.citation: J Rheumatol. 1999 Aug;26(8):1856-7
references.pmid: 10451097
references.citation: Clin Exp Rheumatol. 2001 Jan-Feb;19(1):13-20
references.pmid: 11247319
references.citation: J Rheumatol. 2000 Oct;27(10):2418-23
references.pmid: 11036839
references.citation: Pharm Res. 1995 Jun;12(6):916-22
references.pmid: 7667201
references.citation: Ann Rheum Dis. 2006 May;65(5):688-9
references.pmid: 16611869
references.citation: J Foot Ankle Surg. 2004 Sep-Oct;43(5):285-9
references.pmid: 15480402
references.citation: J Bone Miner Res. 1990 Oct;5(10):1019-27
references.pmid: 2080714
references.citation: Clin Rheumatol. 2004 Aug;23(4):330-2
references.pmid: 15293094
references.citation: Rheumatology (Oxford). 2001 Dec;40(12):1394-7
references.pmid: 11752511
references.citation: J Rheumatol. 2008 Apr;35(4):707-12
references.pmid: 18381777
references.citation: Rheumatology (Oxford). 2004 Oct;43(10):1246-51
references.pmid: 15238641
references.citation: J Pediatr. 2008 Apr;152(4):571-5
references.pmid: 18346517
references.citation: Aust N Z J Med. 1997 Jun;27(3):307-10
references.pmid: 9227815
references.citation: Diabet Med. 1994 Jan-Feb;11(1):28-31
references.pmid: 8181248
references.citation: Clin Rheumatol. 2006 Sep;25(5):683-6
references.pmid: 16391891
references.citation: J Immunol. 2005 Jan 1;174(1):252-60
references.pmid: 15611247
references.citation: Pain. 2001 Apr;91(3):269-275
references.pmid: 11275384
references.citation: Rheumatology (Oxford). 2006 Mar;45(3):339-42
references.pmid: 16249241