How do adhesion proteins stick?
Cadherin homodimerization mediates cell-cell adhesion, but one stabilizing structural element has inspired questions about assembly mechanisms. Combining single molecule fluorescence and force analyses allowed Sivasankar et al. to provide strong evidence for an induced fit pathway to dimerization.
Weninger
Keith
K
D001665:Binding Sites / Q000235:genetics; D015820:Cadherins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D002118:Calcium / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D031541:Fluorescence Resonance Energy Transfer; D006801:Humans; D018625:Microscopy, Atomic Force; D009154:Mutation; D011485:Protein Binding; D011487:Protein Conformation / Q000187:drug effects; D055503:Protein Multimerization; D017434:Protein Structure, Tertiary; D014162:Transfection; D014364:Tryptophan / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism
D015820:Cadherins; D014364:Tryptophan; D002118:Calcium