Radioimmunotherapy: strategies for the future in indolent and aggressive lymphoma.
The conjugation of radioisotopes to monoclonal antibodies, or radioimmunotherapy (RIT), is a highly active treatment in non-Hodgkin's lymphoma. RIT has demonstrated high response rates and durable remissions in extensively pretreated patients and has proved highly effective as consolidation after induction chemotherapy in the first-line therapy of follicular lymphoma. Early-phase clinical trials have shown highly promising results using RIT as part of conditioning regimens in patients who are to undergo transplantation and as consolidation after chemotherapy in patients with aggressive lymphomas. Recent data suggest that integrating RIT with immunochemotherapy and transplant conditioning regimens may further improve outcomes for patients.
Alduaij
Waleed
W
School of Cancer and Imaging Sciences, Paterson Institute for Cancer Research, University of Manchester, Manchester M20 4BX, United Kingdom.
Illidge
Tim M
TM
D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D003131:Combined Modality Therapy; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008223:Lymphoma / Q000473:pathology / Q000532:radiotherapy* / Q000628:therapy; D016499:Radioimmunotherapy / Q000379:methods*; D016019:Survival Analysis; D016896:Treatment Outcome
D000911:Antibodies, Monoclonal
J Clin Oncol. 2003 Apr 1;21(7):1263-70
12663713
N Engl J Med. 1984 Dec 6;311(23):1471-5
6548796
J Clin Oncol. 2005 Feb 1;23(4):712-9
15613695
Semin Radiat Oncol. 2000 Apr;10(2):73-93
10727597
J Clin Oncol. 2008 Jan 1;26(1):90-5
18025438
J Clin Oncol. 2002 Aug 1;20(15):3262-9
12149300
Leuk Lymphoma. 2006 Apr;47(4):629-36
16690521
J Clin Oncol. 2009 Apr 1;27(10):1653-9
19255322
Blood. 2008 Aug 1;112(3):830-5
18502830
J Clin Oncol. 1999 Dec;17(12):3793-803
10577851
Blood. 2004 Jun 15;103(12):4429-31
15016644
Semin Oncol. 1999 Oct;26(5 Suppl 14):58-65
10561019
Blood. 2006 Nov 15;108(10):3295-301
16873669
Clin Cancer Res. 2008 Nov 1;14(21):7088-94
18981007
J Clin Oncol. 1998 Oct;16(10):3270-8
9779701
J Clin Oncol. 2001 Oct 1;19(19):3918-28
11579112
Cancer Sci. 2009 Jan;100(1):158-64
19018755
Blood. 2009 Apr 23;113(17):3891-5
19182204
J Clin Oncol. 2005 Oct 20;23(30):7565-73
16186600
J Clin Oncol. 2005 Aug 20;23(24):5696-704
16110029
N Engl J Med. 2005 Feb 3;352(5):441-9
15689582
Br J Haematol. 2000 Mar;108(4):679-88
10792269
Blood. 2000 Nov 1;96(9):2934-42
11049969
Cancer Biother Radiopharm. 2007 Oct;22(5):684-91
17979571
J Clin Oncol. 2008 Nov 10;26(32):5156-64
18854568
J Clin Oncol. 2003 Jul 1;21(13):2474-80
12829665
N Engl J Med. 2002 Jan 24;346(4):235-42
11807147
Radiother Oncol. 1984 Dec;2(4):317-23
6395213
J Clin Oncol. 2002 May 15;20(10):2453-63
12011122
Blood. 2007 Jul 1;110(1):54-8
17387223
Blood. 2003 Sep 1;102(5):1606-12
12738671
Blood. 2009 Feb 12;113(7):1412-21
19074729
N Engl J Med. 2004 May 20;350(21):2191-3
15118072
J Clin Oncol. 1998 Aug;16(8):2825-33
9704735
J Clin Oncol. 1996 Apr;14(4):1282-90
8648385
J Natl Cancer Inst. 2007 May 2;99(9):706-14
17470738