Brewing complications: the effect of acute ethanol exposure on wound healing.
Ethanol consumption is linked to a higher incidence of traumatic wounds and increases the risk for morbidity and mortality following surgical or traumatic injury. One of the most profound effects of acute ethanol exposure on wound healing occurs during the inflammatory response, and altered cytokine production is a primary component. Acute ethanol exposure also impairs the proliferative response during healing, causing delays in epithelial coverage, collagen synthesis, and blood vessel regrowth. The accumulated data support the paradigm that acute ethanol intoxication prior to injury significantly diminishes a patient's ability to heal efficiently.
Radek
Katherine A
KA
Department of Medicine, Division of Dermatology, University of California at San Diego, La Jolla, California, USA.
Ranzer
Matthew J
MJ
DiPietro
Luisa A
LA
D000063:Accidents, Traffic / Q000706:statistics & numerical data*; D000208:Acute Disease; D000428:Alcohol Drinking / Q000009:adverse effects*; D000818:Animals; D016207:Cytokines / Q000502:physiology; D004195:Disease Models, Animal; D000431:Ethanol / Q000378:metabolism* / Q000633:toxicity; D006801:Humans; D007249:Inflammation / Q000503:physiopathology*; D051379:Mice; D051381:Rats; D012307:Risk Factors; D014481:United States / Q000453:epidemiology; D014945:Wound Healing / Q000502:physiology*; D014947:Wounds and Injuries / Q000453:epidemiology / Q000503:physiopathology
D016207:Cytokines; D000431:Ethanol
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