The genetic susceptibility to respiratory distress syndrome.
Previous studies to identify a genetic component to RDS have shown conflicting results. Our objectives were to evaluate and quantify the genetic contribution to RDS using data that comprehensively includes known environmental factors in a large sample of premature twins. Data from a retrospective chart review of twins born at < or =32 wk GA were obtained from two neonatal units. Mixed effects logistic regression (MELR) analysis was used to assess the influence of several independent covariates on RDS. A zygosity analysis, including the effects of additive genetic, common environmental and residual effects (ACE) factors, was performed to estimate the genetic contribution. Results reveal that the 332 twin pairs had a mean GA of 29.5 wk and birth weight (BW) of 1372 g. An MELR identified significant nongenetic covariates as male gender (p = 0.04), BW (p < 0.001), 5-min Apgar score (p < 0.001), and treating institution (p = 0.001) as significant predictors for RDS. The ACE model was used to estimate the genetic susceptibility to RDS by adjusting for the above factors. We found 49.7% (p = 0.04) of the variance in liability to RDS was the result of genetic factors alone. We conclude that there is a significant genetic susceptibility to RDS in preterm infants.
Levit
Orly
O
Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520, USA.
Jiang
Yuan
Y
Bizzarro
Matthew J
MJ
Hussain
Naveed
N
Buhimschi
Catalin S
CS
Gruen
Jeffrey R
JR
Zhang
Heping
H
Bhandari
Vineet
V
D001724:Birth Weight; D003237:Connecticut; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D016015:Logistic Models; D008297:Male; D008957:Models, Genetic; D012127:Respiratory Distress Syndrome, Newborn / Q000235:genetics*; D014427:Twins
Arch Dis Child Fetal Neonatal Ed. 2001 Mar;84(2):F117-21
11207228
Pediatrics. 2006 Nov;118(5):1858-63
17079555
Pediatr Res. 1998 Feb;43(2):169-77
9475280
Hum Mol Genet. 2000 Nov 1;9(18):2751-60
11063734
Hum Genet. 2001 Sep;109(3):351-5
11702216
Eur J Hum Genet. 2004 Apr;12(4):312-20
14735158
Arch Dis Child Fetal Neonatal Ed. 2004 Mar;89(2):F145-8
14977899
Pediatrics. 2008 Sep;122(3):479-85
18762515
Am J Perinatol. 2005 Apr;22(3):155-9
15838750
Acta Genet Med Gemellol (Roma). 1971 Apr;20(2):199-204
5093127
Biometrics. 2009 Jun;65(2):584-9
18647295
Acta Paediatr. 2007 Jul;96(7):985-9
17524024
J Clin Invest. 1993 Feb;91(2):425-31
8432851
Am J Epidemiol. 2007 Oct 1;166(7):786-94
17625222
Hum Genet. 2003 Jan;112(1):18-23
12483294
Eur Respir J. 1999 Jul;14(1):155-9
10489844
Eur J Pediatr. 2002 Nov;161(11):604-8
12424586
Natl Vital Stat Rep. 2008 Jul 30;57(2):1-32
18972721
Acta Obstet Gynecol Scand. 1993 Jul;72(5):359-64
8392266
J Pediatr. 1996 Oct;129(4):591-6
8859267
Pediatrics. 2006 Jun;117(6):1901-6
16740829
Acta Paediatr. 2009 Jan;98(1):112-7
18785967
Semin Fetal Neonatal Med. 2008 Feb;13(1):24-9
17981103
Int J Gynaecol Obstet. 2000 Feb;68(2):119-22
10717815
Genetics. 2004 Aug;167(4):1529-36
15342495
Pediatrics. 2009 Feb;123(2):669-73
19171636
Am J Respir Crit Care Med. 2003 Nov 15;168(10):1216-22
12947025
Am J Obstet Gynecol. 2007 Feb;196(2):147.e1-8
17306659
Obstet Gynecol. 2008 Mar;111(3):659-66
18310369
J Clin Invest. 1994 Apr;93(4):1860-3
8163685
Am J Hum Genet. 2000 May;66(5):1569-79
10762543
Pediatr Int. 2001 Dec;43(6):567-76
11737731
Semin Perinatol. 2002 Dec;26(6):447-9
12537317
Ann Med. 2006;38(5):357-66
16938805
Am J Obstet Gynecol. 2004 Jul;191(1):271-6
15295378
J Obstet Gynaecol. 2000 Jul;20(4):389-91
15512593