title: Combination analysis of neuropsychological tests and structural MRI measures in differentiating AD, MCI and control groups--the AddNeuroMed study.
abstract: To study the ability of neuropsychological tests, manual MRI hippocampal volume measures, regional volume and cortical thickness measures to identify subjects with Alzheimer's disease (AD), mild cognitive impairment (MCI), and healthy age-matched controls. Neuropsychological tests, manual hippocampal volume, automated regional volume and regional cortical thickness measures were performed in 120 AD patients, 120 MCI subjects, and 111 controls. The regional cortical thickness and volumes in MCI subjects were significantly decreased in limbic/paralimbic areas and temporal lobe compared to controls. Atrophy was much more extensive in the AD patients compared to MCI subjects and controls. The combination of neuropsychological tests and volumes revealed the highest accuracy (82% AD vs. MCI; 94% AD vs. control; 83% MCI vs. control). Adding regional cortical thicknesses into the discriminate analysis did not improve accuracy. We conclude that regional cortical thickness and volume measures provide a panoramic view of brain atrophy in AD and MCI subjects. A combination of neuropsychological tests and regional volumes are important when discriminating AD from healthy controls and MCI.
authors.affiliation: Department of Neurology, University of Kuopio, University Hospital, Kuopio, Finland.
authors.forename: Yawu
authors.initials: Y
authors.lastname: Liu
authors.forename: Teemu
authors.initials: T
authors.lastname: Paajanen
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.forename: Eric
authors.initials: E
authors.lastname: Westman
authors.forename: Lars-Olof
authors.initials: LO
authors.lastname: Wahlund
authors.forename: Andrew
authors.initials: A
authors.lastname: Simmons
authors.forename: Catherine
authors.initials: C
authors.lastname: Tunnard
authors.forename: Tomasz
authors.initials: T
authors.lastname: Sobow
authors.forename: Patrizia
authors.initials: P
authors.lastname: Mecocci
authors.forename: Magda
authors.initials: M
authors.lastname: Tsolaki
authors.forename: Bruno
authors.initials: B
authors.lastname: Vellas
authors.forename: Sebastian
authors.initials: S
authors.lastname: Muehlboeck
authors.forename: Alan
authors.initials: A
authors.lastname: Evans
authors.forename: Christian
authors.initials: C
authors.lastname: Spenger
authors.forename: Simon
authors.initials: S
authors.lastname: Lovestone
authors.forename: Hilkka
authors.initials: H
authors.lastname: Soininen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000523:psychology; D003072:Cognition Disorders / Q000175:diagnosis* / Q000523:psychology; D003937:Diagnosis, Differential; D005260:Female; D006624:Hippocampus / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D009483:Neuropsychological Tests; D011446:Prospective Studies; D012720:Severity of Illness Index