Antioxidant activity of 5,10-dihydroindeno[1,2-b]indoles containing substituents on dihydroindeno part.
An efficient synthesis of 5,10-dihydroindeno[1,2-b]indoles (3a-t) containing substituents such as methoxy, hydroxyl, and halogen (F, Cl, and Br) on indeno part was described. Antioxidant and radical scavenging activities of synthesized compounds (3a-t) were determined by various in vitro assays such as 1,1-diphenyl-2-picryl-hydrazyl free radicals (DPPH(*)), 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid radicals (ABTS(*+)), N,N-dimethyl-p-phenylenediamine dihydrochloride radicals (DMPD(*+)), and superoxide anion radicals (O(2)(*-)) scavenging, reducing ability determination by the Fe(3+)-Fe(2+) and Cu(2+)-Cu(+) (CUPRAC method) transformation methods, H(2)O(2) scavenging, and ferrous ion (Fe(2+)) chelating activities. Moreover, these activities were compared to synthetic and standard antioxidants such as butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), alpha-tocopherol, and trolox. The results showed that the synthesized compounds (3a-t) had effective antioxidant power.
Talaz
Oktay
O
Department of Chemistry, Faculty of Sciences, Atatürk University, 25240-Erzurum, Turkey.
Gülçin
Ilhami
I
Göksu
Süleyman
S
Saracoglu
Nurullah
N
D000975:Antioxidants / Q000737:chemistry* / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000737:chemistry / Q000494:pharmacology; D005609:Free Radicals / Q000378:metabolism; D006861:Hydrogen Peroxide / Q000378:metabolism; D007211:Indoles / Q000737:chemistry* / Q000494:pharmacology*; D007502:Iron Chelating Agents / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure
D000975:Antioxidants; D016166:Free Radical Scavengers; D005609:Free Radicals; D007211:Indoles; D007502:Iron Chelating Agents; D006861:Hydrogen Peroxide