title: Is urinary indolyl-3-acryloylglycine a biomarker for autism with gastrointestinal symptoms?
abstract: An autism spectrum disorder (ASD) diagnosis is based on clinical behaviours as there are no validated biological diagnostic tools. Indolyl-3-acryloylglycine (IAG) is a chemical produced by gut microflora and there are conflicting reports as to whether urinary levels are elevated in children with ASD compared with controls. Urinary IAG levels in morning urine samples were statistically significantly higher in children with ASD whose caregivers reported the presence of chronic gastrointestinal (GI) disturbance than children with ASD without chronic GI disturbance. Urinary IAG, however, was not statistically significantly higher in children with ASD, compared with siblings or unrelated controls without ASD.
authors.affiliation: Sansom Institute, University of South Australia, South Australia, Australia.
authors.forename: Lv
authors.initials: L
authors.lastname: Wang
authors.forename: Manya T
authors.initials: MT
authors.lastname: Angley
authors.forename: Jacobus P
authors.initials: JP
authors.lastname: Gerber
authors.forename: Robyn L
authors.initials: RL
authors.lastname: Young
authors.forename: Damien V
authors.initials: DV
authors.lastname: Abarno
authors.forename: Ross A
authors.initials: RA
authors.lastname: McKinnon
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Sorich
mesh_terms: D001321:Autistic Disorder / Q000150:complications / Q000652:urine*; D015415:Biomarkers; D002648:Child; D002659:Child Development Disorders, Pervasive / Q000175:diagnosis / Q000652:urine*; D003404:Creatinine / Q000652:urine; D005260:Female; D005767:Gastrointestinal Diseases / Q000150:complications / Q000652:urine*; D005998:Glycine / Q000031:analogs & derivatives* / Q000652:urine; D006801:Humans; D008297:Male
chemical_list: D015415:Biomarkers; C001807:indolylacryloylglycine; D003404:Creatinine; D005998:Glycine