title: Synthesis of novel [1,2]-diamines with antituberculosis activity.
abstract: Guided by the metabolism information of SQ109, derivatives with substituted geranylamine moiety or substituted admantane ring of SQ109 were synthesized and evaluated as antituberculosis agents. Among all tested compounds, compound 11c showed the most potent antituberculosis activity with MIC value of 0.3 microM against Mycobacterium tuberculosis H37Rv.
authors.affiliation: Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
authors.forename: Qingyi
authors.initials: Q
authors.lastname: Meng
authors.forename: Huibing
authors.initials: H
authors.lastname: Luo
authors.forename: Yilang
authors.initials: Y
authors.lastname: Chen
authors.forename: Tiancai
authors.initials: T
authors.lastname: Wang
authors.forename: Qizheng
authors.initials: Q
authors.lastname: Yao
mesh_terms: D000995:Antitubercular Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D003959:Diamines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D013329:Structure-Activity Relationship; D014376:Tuberculosis / Q000188:drug therapy
chemical_list: D000995:Antitubercular Agents; D003959:Diamines