Antifungal activity of micafungin in serum.
We have evaluated the antifungal activity of micafungin in serum by using the disk diffusion method with serum-free and serum-added micafungin standard curves. Serum samples from micafungin-treated patients have been shown to exhibit adequate antifungal activity, which was in proportion to both the applied dose and the actual concentration of micafungin measured by high-performance liquid chromatography. The antifungal activity of micafungin in serum was also confirmed with the broth microdilution method.
Ishikawa
Jun
J
Department of Hematology and Oncology, Osaka University School of Medicine, Suita, Osaka, Japan.
Maeda
Tetsuo
T
Matsumura
Itaru
I
Yasumi
Masato
M
Ujiie
Hidetoshi
H
Masaie
Hiroaki
H
Nakazawa
Tsuyoshi
T
Mochizuki
Nobuo
N
Kishino
Satoshi
S
Kanakura
Yuzuru
Y
D000328:Adult; D000935:Antifungal Agents / Q000493:pharmacokinetics / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects*; D002851:Chromatography, High Pressure Liquid; D054714:Echinocandins / Q000493:pharmacokinetics / Q000494:pharmacology*; D005260:Female; D006801:Humans; D055666:Lipopeptides / Q000493:pharmacokinetics / Q000494:pharmacology*; D008297:Male; D000077551:Micafungin; D008875:Middle Aged; D044967:Serum / Q000382:microbiology*; D055815:Young Adult
D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D000077551:Micafungin
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