title: Short- and long-term effects of UV radiation on the pigmentation of human skin.
abstract: The incidence of skin cancer, including cutaneous melanoma, has risen substantially in recent years, and epidemiological and laboratory studies show that UV radiation is a major causative factor of this increase. UV damage also underlies photoaging of the skin, and these deleterious effects of UV can be, in part, prevented in skin with higher levels of constitutive pigmentation. We review the clinical studies we have made in recent years regarding the rapid and the long-term responses of the pigmentary system in human skin to UV exposure.Journal of Investigative Dermatology Symposium Proceedings (2009) 14, 32-35; doi:10.1038/jidsymp.2009.10.
authors.affiliation: Pigment Cell Biology Section, Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
authors.forename: Sergio G
authors.initials: SG
authors.lastname: Coelho
authors.forename: Wonseon
authors.initials: W
authors.lastname: Choi
authors.forename: Michaela
authors.initials: M
authors.lastname: Brenner
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Miyamura
authors.forename: Yuji
authors.initials: Y
authors.lastname: Yamaguchi
authors.forename: Rainer
authors.initials: R
authors.lastname: Wolber
authors.forename: Christoph
authors.initials: C
authors.lastname: Smuda
authors.forename: Jan
authors.initials: J
authors.lastname: Batzer
authors.forename: Ludger
authors.initials: L
authors.lastname: Kolbe
authors.forename: Shosuke
authors.initials: S
authors.lastname: Ito
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Wakamatsu
authors.forename: Barbara Z
authors.initials: BZ
authors.lastname: Zmudzka
authors.forename: Janusz Z
authors.initials: JZ
authors.lastname: Beer
authors.forename: Sharon A
authors.initials: SA
authors.lastname: Miller
authors.forename: Vincent J
authors.initials: VJ
authors.lastname: Hearing
mesh_terms: D002452:Cell Count; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D007150:Immunohistochemistry; D008543:Melanins / Q000378:metabolism; D008544:Melanocytes / Q000378:metabolism / Q000473:pathology / Q000528:radiation effects; D012867:Skin / Q000378:metabolism / Q000473:pathology / Q000528:radiation effects; D012880:Skin Pigmentation / Q000528:radiation effects*; D013997:Time Factors; D014466:Ultraviolet Rays / Q000009:adverse effects*
chemical_list: D008543:Melanins
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