title: The role of PTEN-induced kinase 1 in mitochondrial dysfunction and dynamics.
abstract: Mutations in parkin, PTEN-induced kinase 1 (PINK1) and DJ-1 can all cause autosomal recessive forms of Parkinson's disease. Recent data suggest that these recessive parkinsonism-associated genes converge within a single pathogenic pathway whose dysfunction leads to the loss of substantia nigra pars compacta neurons. The major common functional effects of all three genes relate to mitochondrial and oxidative damage, with a possible additional involvement of the ubiquitin proteasome system. This review highlights the role of the mitochondrial kinase, PINK1, in protection against mitochondrial dysfunction and how this might relate to loss of substantia nigra neurons in recessive parkinsonism.
authors.affiliation: Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD 20892, USA.
authors.forename: Kelly Jean
authors.initials: KJ
authors.lastname: Thomas
authors.forename: Mark R
authors.initials: MR
authors.lastname: Cookson
mesh_terms: D000818:Animals; D006801:Humans; D008928:Mitochondria / Q000378:metabolism* / Q000473:pathology*; D008954:Models, Biological; D018384:Oxidative Stress / Q000235:genetics / Q000502:physiology; D020734:Parkinsonian Disorders / Q000201:enzymology / Q000503:physiopathology; D011494:Protein Kinases / Q000235:genetics / Q000378:metabolism*; D000099202:PTEN-Induced Putative Kinase
chemical_list: D011494:Protein Kinases; D000099202:PTEN-Induced Putative Kinase
references.citation: Ann Neurol. 2006 Oct;60(4):414-9
references.pmid: 16969854
references.citation: FEBS Lett. 2002 Jul 17;523(1-3):171-6
references.pmid: 12123827
references.citation: Curr Biol. 2005 Apr 12;15(7):678-83
references.pmid: 15823542
references.citation: Neurobiol Aging. 2006 Apr;27(4):524-9
references.pmid: 16213628
references.citation: J Biol Chem. 2005 Jul 15;280(28):26185-92
references.pmid: 15899901
references.citation: J Neurochem. 2008 Jul;106(1):464-74
references.pmid: 18397367
references.citation: Nat Genet. 2006 May;38(5):515-7
references.pmid: 16604074
references.citation: Nat Rev Neurosci. 2008 Nov;9(11):826-38
references.pmid: 18931696
references.citation: J Neurochem. 2008 Jun;105(5):1806-19
references.pmid: 18248624
references.citation: J Cell Sci. 2004 Mar 1;117(Pt 7):1201-10
references.pmid: 14996942
references.citation: Neurology. 2000 Aug 22;55(4):533-8
references.pmid: 10953187
references.citation: Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14503-8
references.pmid: 18799731
references.citation: Proteomics. 2007 Jun;7(13):2189-200
references.pmid: 17533645
references.citation: Hum Genet. 2001 Dec;109(6):584-91
references.pmid: 11810270
references.citation: Hum Mol Genet. 2008 Feb 15;17(4):602-16
references.pmid: 18003639
references.citation: Proc Natl Acad Sci U S A. 2006 Jul 11;103(28):10793-8
references.pmid: 16818890
references.citation: Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):2696-701
references.pmid: 8610103
references.citation: Nature. 1995 Jul 27;376(6538):313-20
references.pmid: 7630397
references.citation: Biochem Biophys Res Commun. 2003 Jan 10;300(2):482-93
references.pmid: 12504110
references.citation: J Struct Biol. 2004 Sep;147(3):259-67
references.pmid: 15450295
references.citation: Hum Mol Genet. 2006 Mar 15;15(6):883-95
references.pmid: 16449237
references.citation: Neurology. 2004 Oct 26;63(8):1486-8
references.pmid: 15505171
references.citation: EMBO J. 2008 Jan 23;27(2):433-46
references.pmid: 18200046
references.citation: Ann Neurol. 1998 Dec;44(6):873-81
references.pmid: 9851431
references.citation: Ann Neurol. 2004 Sep;56(3):427-31
references.pmid: 15349871
references.citation: J Cell Sci. 2005 Sep 15;118(Pt 18):4141-51
references.pmid: 16118244
references.citation: PLoS Biol. 2007 Jul;5(7):e172
references.pmid: 17579517
references.citation: J Cell Biol. 2007 Aug 27;178(5):749-55
references.pmid: 17709429
references.citation: Brain. 2006 Jul;129(Pt 7):1720-31
references.pmid: 16702191
references.citation: J Cell Biol. 2007 Aug 27;178(5):757-64
references.pmid: 17709430
references.citation: Curr Opin Chem Biol. 2004 Dec;8(6):610-6
references.pmid: 15556404
references.citation: J Cell Biol. 2006 Jun 5;173(5):645-50
references.pmid: 16735578
references.citation: Biochemistry. 2009 Mar 10;48(9):2045-52
references.pmid: 19152501
references.citation: J Neurochem. 1989 Feb;52(2):381-9
references.pmid: 2911023
references.citation: J Cell Biol. 2005 Sep 26;170(7):1021-7
references.pmid: 16186251
references.citation: J Biol Chem. 2003 Mar 7;278(10):7743-6
references.pmid: 12509422
references.citation: J Mol Biol. 2003 Nov 28;334(3):445-58
references.pmid: 14623186
references.citation: Mol Biol Cell. 2004 Nov;15(11):5001-11
references.pmid: 15356267
references.citation: Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2653-8
references.pmid: 16477035
references.citation: Oncogene. 2001 Jul 27;20(33):4457-65
references.pmid: 11494141
references.citation: Ann Neurol. 1996 Oct;40(4):663-71
references.pmid: 8871587
references.citation: Neurosci Lett. 2008 Jan 3;430(1):13-7
references.pmid: 18031932
references.citation: J Cell Biol. 1998 Oct 19;143(2):333-49
references.pmid: 9786946
references.citation: PLoS One. 2008 Jun 18;3(6):e2455
references.pmid: 18560593
references.citation: J Cell Biol. 2003 Jan 20;160(2):189-200
references.pmid: 12527753
references.citation: J Cell Sci. 2002 Apr 15;115(Pt 8):1663-74
references.pmid: 11950885
references.citation: Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1638-43
references.pmid: 18230723
references.citation: Hum Mol Genet. 2005 Aug 1;14(15):2099-111
references.pmid: 15961413
references.citation: Ann Neurol. 1992 Jul;32(1):113-4
references.pmid: 1642467
references.citation: Cell. 2006 Oct 20;127(2):383-95
references.pmid: 17055438
references.citation: J Cell Biol. 2004 Sep 27;166(7):1027-39
references.pmid: 15452144
references.citation: Nat Genet. 2006 May;38(5):518-20
references.pmid: 16604072
references.citation: J Biochem. 2008 Apr;143(4):449-54
references.pmid: 18174190
references.citation: J Biol Chem. 2004 Aug 20;279(34):35967-74
references.pmid: 15208300
references.citation: Neurobiol Dis. 2007 Feb;25(2):401-11
references.pmid: 17141510
references.citation: Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):11664-8
references.pmid: 8876193
references.citation: Int J Biochem Cell Biol. 2005 Dec;37(12):2478-503
references.pmid: 16103002
references.citation: J Biol Chem. 2004 Apr 30;279(18):18792-8
references.pmid: 14970223
references.citation: Mol Cell Biol. 2003 Aug;23(15):5409-20
references.pmid: 12861026
references.citation: Dev Cell. 2007 May;12(5):793-806
references.pmid: 17488629
references.citation: Ann Neurol. 1989 Dec;26(6):719-23
references.pmid: 2557792
references.citation: Mov Disord. 2008 Apr 30;23(6):881-5
references.pmid: 18307263
references.citation: J Biol Chem. 2008 May 16;283(20):13501-5
references.pmid: 18372247
references.citation: Am J Physiol. 1997 Apr;272(4 Pt 1):C1286-94
references.pmid: 9142854
references.citation: Mol Biol Cell. 2001 Aug;12(8):2245-56
references.pmid: 11514614
references.citation: Hum Mol Genet. 2005 Nov 15;14(22):3477-92
references.pmid: 16207731
references.citation: Mol Cell Biochem. 2004 Jan-Feb;256-257(1-2):331-9
references.pmid: 14977192
references.citation: J Cell Sci. 2001 Mar;114(Pt 5):867-74
references.pmid: 11181170
references.citation: Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11364-9
references.pmid: 18687901
references.citation: Mov Disord. 2006 Jun;21(6):789-93
references.pmid: 16482571
references.citation: J Cell Biol. 2006 May 22;173(4):545-57
references.pmid: 16717129
references.citation: J Biol Chem. 2005 May 13;280(19):18598-603
references.pmid: 15760898
references.citation: Science. 2004 Sep 17;305(5691):1747-52
references.pmid: 15297626
references.citation: Mol Biol Cell. 2007 Aug;18(8):3105-18
references.pmid: 17553932
references.citation: Mov Disord. 1997 Jan;12(1):3-8
references.pmid: 8990047
references.citation: EMBO J. 2001 Dec 3;20(23):6627-36
references.pmid: 11726499
references.citation: Proc Natl Acad Sci U S A. 2007 Jul 10;104(28):11649-54
references.pmid: 17606912
references.citation: Neurosci Res. 2008 May;61(1):43-8
references.pmid: 18359116
references.citation: Ann Neurol. 1999 Dec;46(6):920-4
references.pmid: 10589547
references.citation: Lancet. 1989 Jun 3;1(8649):1269
references.pmid: 2566813
references.citation: Cancer Res. 2004 Feb 1;64(3):985-93
references.pmid: 14871829
references.citation: Cell. 2006 Jul 14;126(1):163-75
references.pmid: 16839884
references.citation: Nature. 2006 Jun 29;441(7097):1162-6
references.pmid: 16672981
references.citation: EMBO Rep. 2007 Oct;8(10):939-44
references.pmid: 17721437
references.citation: Toxicol Appl Pharmacol. 1996 Mar;137(1):34-41
references.pmid: 8607139
references.citation: Semin Cell Dev Biol. 1998 Aug;9(4):433-44
references.pmid: 9813190
references.citation: J Cell Biol. 2008 Dec 1;183(5):795-803
references.pmid: 19029340
references.citation: Proc Natl Acad Sci U S A. 1978 Aug;75(8):3863-6
references.pmid: 80800
references.citation: J Neurosci. 2003 Aug 27;23(21):7881-8
references.pmid: 12944518
references.citation: Nature. 2006 Jun 29;441(7097):1157-61
references.pmid: 16672980
references.citation: J Biol Chem. 2005 Apr 29;280(17):17154-62
references.pmid: 15737990
references.citation: Neurochem Res. 2008 Dec;33(12):2565-74
references.pmid: 18473170
references.citation: Exp Neurol. 2008 Aug;212(2):307-13
references.pmid: 18511044
references.citation: Hum Mol Genet. 2003 Mar 1;12(5):517-26
references.pmid: 12588799
references.citation: Proc Natl Acad Sci U S A. 2004 Nov 9;101(45):15927-32
references.pmid: 15509649
references.citation: Neurobiol Dis. 2007 Nov;28(2):216-26
references.pmid: 17707122
references.citation: EMBO J. 1998 May 1;17(9):2451-62
references.pmid: 9564028
references.citation: J Neurosci. 2007 Nov 7;27(45):12413-8
references.pmid: 17989306
references.citation: Brain Res. 2002 Mar 15;930(1-2):143-9
references.pmid: 11879804
references.citation: J Biol Chem. 2005 Oct 7;280(40):34025-32
references.pmid: 16079129
references.citation: Nat Struct Biol. 2001 Feb;8(2):176-83
references.pmid: 11175909
references.citation: Nature. 2006 May 25;441(7092):528-31
references.pmid: 16648839
references.citation: Dev Cell. 2007 May;12(5):807-16
references.pmid: 17488630
references.citation: J Biol Chem. 2007 Jul 27;282(30):21583-7
references.pmid: 17553808
references.citation: Development. 2004 May;131(9):2183-94
references.pmid: 15073152
references.citation: Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):12022-7
references.pmid: 18687899
references.citation: J Neurochem. 2007 Oct;103(1):303-11
references.pmid: 17587308
references.citation: J Biol Chem. 1991 Oct 15;266(29):19328-33
references.pmid: 1655783
references.citation: J Biol Chem. 2005 Apr 29;280(17):16619-24
references.pmid: 15718234
references.citation: J Cell Sci. 2004 Dec 15;117(Pt 26):6535-46
references.pmid: 15572413
references.citation: Ann Neurol. 1992 Dec;32(6):782-8
references.pmid: 1471869
references.citation: Ann Neurol. 2000 Nov;48(5):774-81
references.pmid: 11079541
references.citation: Annu Rev Genet. 2005;39:503-36
references.pmid: 16285870
references.citation: Science. 2004 Aug 6;305(5685):858-62
references.pmid: 15297672
references.citation: Hum Mutat. 2007 Jan;28(1):98
references.pmid: 17154281
references.citation: J Cell Biol. 1998 Oct 19;143(2):359-73
references.pmid: 9786948
references.citation: Biochem Biophys Res Commun. 2005 Dec 2;337(4):1133-8
references.pmid: 16226715
references.citation: J Cell Sci. 2007 Apr 1;120(Pt 7):1178-88
references.pmid: 17341580
references.citation: J Cell Biol. 2007 Jul 2;178(1):71-84
references.pmid: 17606867
references.citation: Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4078-83
references.pmid: 12642658
references.citation: Neuron. 2002 Dec 19;36(6):1063-77
references.pmid: 12495622
references.citation: Biophys J. 1999 Feb;76(2):725-34
references.pmid: 9929477
references.citation: Hum Mol Genet. 2006 Nov 1;15(21):3251-62
references.pmid: 17000703
references.citation: Dev Biol. 2007 Mar 1;303(1):108-20
references.pmid: 17123504
references.citation: Proteins. 2004 Jan 1;54(1):153-6
references.pmid: 14705031
references.citation: Mech Dev. 2002 Aug;116(1-2):213-6
references.pmid: 12128227
references.citation: J Neurosci Res. 2006 Nov 15;84(7):1543-54
references.pmid: 16955485
references.citation: Nat Rev Mol Cell Biol. 2004 Feb;5(2):133-47
references.pmid: 15040446
references.citation: J Cell Biol. 2007 May 7;177(3):439-50
references.pmid: 17470634
references.citation: Science. 2004 May 21;304(5674):1158-60
references.pmid: 15087508
references.citation: J Neurochem. 2006 Aug;98(3):951-61
references.pmid: 16771836
references.citation: Science. 1983 Feb 25;219(4587):979-80
references.pmid: 6823561
references.citation: Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1716-21
references.pmid: 18218782
references.citation: Ann Neurol. 2004 Sep;56(3):336-41
references.pmid: 15349860
references.citation: Biomed Khim. 2008 Jan-Feb;54(1):58-77
references.pmid: 18421912
references.citation: Cell. 1997 Jul 11;90(1):121-9
references.pmid: 9230308
references.citation: Hum Mol Genet. 2006 Jun 1;15(11):1816-25
references.pmid: 16632486
references.citation: Ann Neurol. 2000 Nov;48(5):737-44
references.pmid: 11079537
references.citation: Proc Natl Acad Sci U S A. 2007 Jul 3;104(27):11441-6
references.pmid: 17563363
references.citation: Brain Res. 1984 Feb 6;292(2):390-4
references.pmid: 6607092
references.citation: Proc Natl Acad Sci U S A. 2006 Sep 5;103(36):13520-5
references.pmid: 16938835
references.citation: Neurology. 2005 Jun 14;64(11):1955-7
references.pmid: 15955953
references.citation: Cell Death Differ. 2000 Feb;7(2):137-44
references.pmid: 10713728
references.citation: Proc Natl Acad Sci U S A. 2005 Apr 19;102(16):5703-8
references.pmid: 15824318
references.citation: J Biol Chem. 2007 Apr 13;282(15):11521-9
references.pmid: 17301055
references.citation: J Neurochem. 2006 Jul;98(1):156-69
references.pmid: 16805805
references.citation: Curr Biol. 2004 Feb 17;14(4):340-5
references.pmid: 14972687
references.citation: Annu Rev Biochem. 2007;76:751-80
references.pmid: 17362197
references.citation: J Biochem. 2003 Sep;134(3):333-44
references.pmid: 14561718
references.citation: Nat Rev Mol Cell Biol. 2005 Aug;6(8):657-63
references.pmid: 16025099
references.citation: J Biol Chem. 2000 Nov 17;275(46):35661-4
references.pmid: 10973942
references.citation: Antioxid Redox Signal. 2008 Aug;10(8):1313-42
references.pmid: 18435594
references.citation: Apoptosis. 2007 May;12(5):835-40
references.pmid: 17136322
references.citation: Neurosci Lett. 1992 Aug 17;142(2):128-30
references.pmid: 1454205
references.citation: J Cell Sci. 2004 Sep 1;117(Pt 19):4389-400
references.pmid: 15304525
references.citation: Nature. 2006 Oct 12;443(7112):658-62
references.pmid: 17035996
references.citation: Brain Res. 1986 Jun 18;376(1):117-24
references.pmid: 3487376
references.citation: Proc Natl Acad Sci U S A. 2008 May 13;105(19):7070-5
references.pmid: 18443288
references.citation: Mol Cell. 2006 Mar 17;21(6):761-73
references.pmid: 16543146
references.citation: Sci Am. 1997 Aug;277(2):40-7
references.pmid: 9245840
references.citation: Cancer Lett. 2003 Nov 25;201(2):195-201
references.pmid: 14607334
references.citation: Neurology. 2006 Apr 11;66(7):1129-30; author reply 1129-30
references.pmid: 16606941
references.citation: J Exp Med. 1999 Jan 18;189(2):381-94
references.pmid: 9892620
references.citation: Mov Disord. 2006 Jun;21(6):875-9
references.pmid: 16547921
references.citation: Traffic. 2007 May;8(5):500-11
references.pmid: 17451553
references.citation: Int J Biochem Cell Biol. 1995 Feb;27(2):97-108
references.pmid: 7767791
references.citation: Ann Neurol. 2008 Nov;64(5):555-65
references.pmid: 19067348
references.citation: PLoS Genet. 2008 Jan;4(1):e6
references.pmid: 18193945
references.citation: Brain Res. 2007 Dec 12;1184:10-6
references.pmid: 17950257
references.citation: Biochim Biophys Acta. 2006 May-Jun;1757(5-6):518-24
references.pmid: 16829229
references.citation: J Histochem Cytochem. 2000 Jan;48(1):45-56
references.pmid: 10653585
references.citation: Hum Mol Genet. 2003 Nov 15;12(22):2957-65
references.pmid: 14519684
references.citation: Clin Genet. 2005 Nov;68(5):468-70
references.pmid: 16207217
references.citation: J Neurosci. 2003 Apr 15;23(8):3316-24
references.pmid: 12716939
references.citation: J Biol Chem. 2006 Dec 8;281(49):37972-9
references.pmid: 17003040
references.citation: Acta Neurol Scand Suppl. 1989;126:47-54
references.pmid: 2618593
references.citation: Nat Cell Biol. 2007 Nov;9(11):1243-52
references.pmid: 17906618
references.citation: Nature. 2003 May 29;423(6939):537-41
references.pmid: 12774122
references.citation: Nat Neurosci. 2000 Dec;3(12):1301-6
references.pmid: 11100151