title: Solution-phase parallel synthesis of substituted chalcones and their antiparasitary activity against Giardia lamblia.
abstract: A library of 25-membered chalcones was prepared by parallel synthesis. Substituted acetophenones and benzaldehydes were condensed using the Claisen-Schmidt base-catalyzed aldol condensation. Several chalcones showed in vitro antiparasitic activity against Giardia lamblia. The highest activity observed for the IC(50) values were 12.72, 15.05 and 15.31 microg/mL, respectively; these are potential leads for the development of antigiardial compounds.
authors.affiliation: Centro de Graduados e Investigación, Instituto Tecnológico de Tijuana, PO Box 1166, 22000 Tijuana, B.C., Mexico.
authors.forename: Julio
authors.initials: J
authors.lastname: Montes-Avila
authors.forename: Sylvia P
authors.initials: SP
authors.lastname: Díaz-Camacho
authors.forename: Josefina
authors.initials: J
authors.lastname: Sicairos-Félix
authors.forename: Francisco
authors.initials: F
authors.lastname: Delgado-Vargas
authors.forename: I A
authors.initials: IA
authors.lastname: Rivero
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D047188:Chalcones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D016829:Giardia lamblia / Q000187:drug effects*; D020128:Inhibitory Concentration 50; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
chemical_list: D000981:Antiprotozoal Agents; D047188:Chalcones