title: ATF3 transcription factor and its emerging roles in immunity and cancer.
abstract: Activating transcription factor 3 (ATF3) is a member of the ATF/cyclic AMP response element-binding (ATF/CREB) family of transcription factors. It is an adaptive-response gene that participates in cellular processes to adapt to extra- and/or intracellular changes, where it transduces signals from various receptors to activate or repress gene expression. Advances made in understanding the immunobiology of Toll-like receptors have recently generated new momentum for the study of ATF3 in immunity. Moreover, the role of ATF3 in the regulation of the cell cycle and apoptosis has important implications for understanding susceptibility to and progression of several cancers.
authors.affiliation: Monash Institute of Medical Research, Monash University, Melbourne, Australia.
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Thompson
authors.forename: Dakang
authors.initials: D
authors.lastname: Xu
authors.forename: Bryan R G
authors.initials: BR
authors.lastname: Williams
mesh_terms: D051700:Activating Transcription Factor 3 / Q000235:genetics* / Q000276:immunology* / Q000378:metabolism; D000818:Animals; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007113:Immunity, Innate; D009369:Neoplasms / Q000235:genetics / Q000276:immunology*
chemical_list: D051700:Activating Transcription Factor 3
references.citation: Oncogene. 2005 Mar 3;24(10):1774-87
references.pmid: 15674352
references.citation: Cancer Res. 2006 Dec 15;66(24):11983-90
references.pmid: 17178897
references.citation: Anticancer Res. 1999 May-Jun;19(3A):1779-83
references.pmid: 10470115
references.citation: J Immunol. 2007 Sep 15;179(6):3622-30
references.pmid: 17785797
references.citation: Diabetes. 2008 Mar;57(3):635-44
references.pmid: 18057093
references.citation: Mol Cancer Ther. 2005 Feb;4(2):233-41
references.pmid: 15713895
references.citation: Cancer Res. 2004 Aug 15;64(16):5850-60
references.pmid: 15313929
references.citation: Cancer Res. 2006 Feb 15;66(4):2376-84
references.pmid: 16489044
references.citation: Jpn J Cancer Res. 2000 Aug;91(8):833-6
references.pmid: 10965025
references.citation: J Biol Chem. 2008 Oct 31;283(44):29795-801
references.pmid: 18755691
references.citation: J Biol Chem. 2006 Apr 14;281(15):10473-81
references.pmid: 16469745
references.citation: J Biol Chem. 1988 Dec 5;263(34):18466-72
references.pmid: 2848037
references.citation: Exp Cell Res. 2001 Jul 15;267(2):193-204
references.pmid: 11426938
references.citation: BMC Cancer. 2008 Sep 22;8:268
references.pmid: 18808719
references.citation: Nature. 1987 Jul 9-15;328(6126):175-8
references.pmid: 2885756
references.citation: Oncogene. 2008 Apr 3;27(15):2118-27
references.pmid: 17952119
references.citation: Nature. 2006 May 11;441(7090):173-8
references.pmid: 16688168
references.citation: Nat Med. 2003 Jan;9(1):33-9
references.pmid: 12496961
references.citation: J Urol. 2006 Apr;175(4):1517-22
references.pmid: 16516039
references.citation: Blood. 2006 Mar 15;107(6):2536-9
references.pmid: 16263788
references.citation: J Exp Med. 2008 Sep 29;205(10):2349-57
references.pmid: 18794337
references.citation: Genes Dev. 1998 Apr 1;12(7):982-95
references.pmid: 9531536
references.citation: J Biol Chem. 1995 May 19;270(20):12210-8
references.pmid: 7744871
references.citation: Mol Cancer Ther. 2005 May;4(5):693-703
references.pmid: 15897233
references.citation: Nat Immunol. 2009 Apr;10(4):437-43
references.pmid: 19270711
references.citation: Mol Endocrinol. 1994 Jan;8(1):59-68
references.pmid: 8152431
references.citation: Proc Natl Acad Sci U S A. 1991 May 1;88(9):3720-4
references.pmid: 1827203
references.citation: Gene Expr. 1999;7(4-6):321-35
references.pmid: 10440233
references.citation: Mol Carcinog. 2007 Jun;46(6):476-87
references.pmid: 17295236
references.citation: Nature. 1998 Feb 26;391(6670):900-4
references.pmid: 9495343
references.citation: Mol Cell Biol. 1997 Nov;17(11):6700-7
references.pmid: 9343434
references.citation: Adv Drug Deliv Rev. 2000 Nov 15;44(2-3):119-34
references.pmid: 11072110
references.citation: Oncogene. 2006 Mar 13;25(11):1620-8
references.pmid: 16550162
references.citation: Biochem J. 1999 Apr 1;339 ( Pt 1):135-41
references.pmid: 10085237
references.citation: Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):652-6
references.pmid: 18178624
references.citation: Cell Cycle. 2007 Mar 15;6(6):705-13
references.pmid: 17374994
references.citation: Science. 2007 Jul 6;317(5834):124-7
references.pmid: 17615359
references.citation: Mol Cell Biol. 2004 Jul;24(13):5721-32
references.pmid: 15199129
references.citation: Springer Semin Immunopathol. 2000;22(1-2):125-32
references.pmid: 10944807
references.citation: Carcinogenesis. 2004 Nov;25(11):2155-64
references.pmid: 15271854
references.citation: Mol Immunol. 2007 Mar;44(7):1598-605
references.pmid: 16982098
references.citation: Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2544-9
references.pmid: 18268321
references.citation: J Biol Chem. 1994 Jun 3;269(22):15819-26
references.pmid: 7515060
references.citation: Mol Cell Biol. 1992 Oct;12(10):4654-65
references.pmid: 1406655
references.citation: Differentiation. 2006 Dec;74(9-10):481-7
references.pmid: 17177845
references.citation: Cell Death Differ. 2006 May;13(5):816-25
references.pmid: 16410796
references.citation: Proc Natl Acad Sci U S A. 1991 May 1;88(9):3511-5
references.pmid: 1902565
references.citation: Genes Dev. 1989 Dec;3(12B):2083-90
references.pmid: 2516827
references.citation: J Biol Chem. 2003 Jul 11;278(28):25790-801
references.pmid: 12734198
references.citation: Mol Cell. 2003 Apr;11(4):915-26
references.pmid: 12718878