title: Clinical observation on treatment of Tourette syndrome by integrative medicine.
abstract: OBJECTIVE
  To explore the clinical efficacy of integrative Chinese and Western medicine in treating Tourette syndrome (TS).
  
  
  METHODS
  Ninety children with TS were randomized into two groups by randomizing: digital table method: the 60 patients in the treated group were treated by Ningdong Granule (NDG) plus haloperidol, and the 30 in the control group treated by haloperidol alone. The course for both groups was 6 months. Conditions of the patients were estimated before and after treatment with Yale Global Tic Severity Scale (YGTSS), the short-term efficacy, adverse reaction of treatment were assessed at the end of treatment, and the long-term efficacy as well as the recurrent rate were evaluated half a year after the treatment was ended.
  
  
  RESULTS
  Of the 60 patients in the treated group, the treatment on 36 was evaluated as remarkably effective, 21 as effective, and 3 as ineffective, the total effective rate being 95.0% (57/60), while of the 30 patients in the control group, the corresponding data were 9, 13, 8 and 73.3% (22/30), respectively, differences between groups in markedly effective rate and total effective rate were statistically significant (chi(2)=7.20, and chi(2)=6.85, P<0.01). The improvement on the condition of illness, motor tic and vocal tic, as well as the long-term efficacy of treatment were all better in the treated group than in the control group (P<0.05 or P<0.01). The incidence of adverse reaction and the recurrent rate in the treated group were 13.3% (8/60) and 8.3% (5/60) respectively, all were lower than those in the control group, 36.7% (11/30) and 43.3 (13/30), showing statistical significances (P<0.05 and P<0.01).
  
  
  CONCLUSIONS
  Integrative medical treatment on TS was markedly effective in clinical practice with less adverse reaction and lower recurrent rate.
authors.affiliation: Department of Integrative Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, 250021, China. sdslyy@163.com
authors.forename: An-yuan
authors.initials: AY
authors.lastname: Li
authors.forename: Shan
authors.initials: S
authors.lastname: Cong
authors.forename: Hong
authors.initials: H
authors.lastname: Lu
authors.forename: Ji-jun
authors.initials: JJ
authors.lastname: Li
authors.forename: Lin
authors.initials: L
authors.lastname: Zhao
mesh_terms: D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000009:adverse effects; D002648:Child; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006220:Haloperidol / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D055048:Integrative Medicine / Q000379:methods*; D008297:Male; D012008:Recurrence; D012720:Severity of Illness Index; D020323:Tics / Q000188:drug therapy / Q000453:epidemiology; D005879:Tourette Syndrome / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents; D004365:Drugs, Chinese Herbal; C545316:ningdong; D006220:Haloperidol
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