A phenylpropanoid, a slovenolide, two sulphur-containing germacranes and Ca2+-ATPase inhibitors from Thapsia villosa.
A phenylpropanoid 1, a slovenolide 2, and two germacranes bearing a methylthiopropenoate moiety, 3 and 4, along with twenty known metabolites have been isolated from the roots of Thapsia villosa var. villosa L. The structures of two known phenylpropanoids 5 and 6 have been corrected. Compounds 7 and 8 showed activity as potential inhibitors of the sarco- and endoplasmic Ca(2+)-dependent ATPases (SERCA) pump. Compounds 9, 10 and 11 increased significantly the cytoplasmic free calcium concentration ([Ca(2+)](c)) in human platelets in a concentration-dependent manner.
Rubal
Juan J
JJ
Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Cádiz, Puerto Real, Cádiz, Spain.
Moreno-Dorado
F Javier
FJ
Guerra
Francisco M
FM
Jorge
Zacarías D
ZD
Galán
María del Carmen
Mdel C
Salido
Ginés M
GM
Christensen
Søren B
SB
Søhoel
Helmer
H
Massanet
Guillermo M
GM
D001792:Blood Platelets / Q000378:metabolism*; D002118:Calcium / Q000097:blood*; D000252:Calcium-Transporting ATPases / Q000037:antagonists & inhibitors*; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D006575:Heterocyclic Compounds, 3-Ring / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D007783:Lactones / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018517:Plant Roots; D020005:Propanols / Q000737:chemistry / Q000302:isolation & purification; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D045788:Sesquiterpenes, Germacrane / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D045789:Sesquiterpenes, Guaiane / Q000302:isolation & purification / Q000494:pharmacology; D013438:Sulfhydryl Compounds / Q000302:isolation & purification; D013455:Sulfur; D053629:Thapsia / Q000737:chemistry*
C549778:2,10,11-triacetoxy-8-(3-methyltiopropanoyloxy)slov-3-enolide; D004791:Enzyme Inhibitors; D006575:Heterocyclic Compounds, 3-Ring; D007783:Lactones; D010936:Plant Extracts; D020005:Propanols; D012717:Sesquiterpenes; D045788:Sesquiterpenes, Germacrane; D045789:Sesquiterpenes, Guaiane; D013438:Sulfhydryl Compounds; C549777:thapsitranstagin; C439395:1-phenylpropanol; D013455:Sulfur; D000252:Calcium-Transporting ATPases; D002118:Calcium