Effect of chronic smoking on lipid peroxidation and antioxidant status in gastric carcinoma patients.
Oxidative stress plays an important role in malignant transformation and is postulated to be associated with increased lipid peroxidation. We determined the effects of chronic cigarette smoking on lipid peroxidation and antioxidant status in 100 male patients with gastric cancer and an equal number of age-matched healthy control subjects. The mean (SD) level of thiobarbituric acid reactive substances (TBARS) was higher in plasma (healthy non-smokers 3.1 [0.2]; healthy smokers 4.6 [0.2]; gastric cancer non-smokers 6.5 [1.0]; gastric cancer smokers 8.9 [3.1]) and erythrocytes (3.3 [0.6]; 4.6 [0.1]; 8.3 [0.9]; 13.2 [5.1]) from gastric cancer patients when compared with control subjects. TBARS level was higher in smokers than non-smoking gastric cancer patients. The activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-treansferase, reduced glutathione, and vitamins A, E and C were decreased in gastric cancer patients who were smokers as compared to other groups (p<0.001). Thus, there occurs lipid peroxidation and possible breakdown of antioxidant status in cigarette smoking, which may increase the risk of gastric cancer.
Pasupathi
Palanisamy
P
Institute of Laboratory Medicine, K.G. Hospital, Coimbatore, Tamil Nadu, India, drppasupathi@gmail.com
Saravanan
Ganesan
G
Chinnaswamy
Palanisamy
P
Bakthavathsalam
Govindaswamy
G
D000975:Antioxidants / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000097:blood; D001706:Biopsy; D002374:Catalase / Q000097:blood; D002908:Chronic Disease; D005500:Follow-Up Studies; D005978:Glutathione / Q000097:blood; D005982:Glutathione Transferase / Q000097:blood; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D012907:Smoking / Q000009:adverse effects* / Q000097:blood; D013274:Stomach Neoplasms / Q000097:blood* / Q000473:pathology; D013482:Superoxide Dismutase / Q000097:blood; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014815:Vitamins / Q000097:blood
D000975:Antioxidants; D014408:Biomarkers, Tumor; D017392:Thiobarbituric Acid Reactive Substances; D014815:Vitamins; D002374:Catalase; D013482:Superoxide Dismutase; D005982:Glutathione Transferase; D005978:Glutathione
J Prev Med Public Health. 2007 Nov;40(6):467-74
18063902
Arch Biochem Biophys. 1959 May;82(1):70-7
13650640
J Nutr Biochem. 2005 Oct;16(10):577-86
16111877
Eur J Surg Oncol. 2007 May;33(4):474-9
17129702
Science. 1973 Feb 9;179(4073):588-90
4686466
Cell Biochem Funct. 1997 Mar;15(1):15-8
9075332
Chem Phys Lipids. 1987 Nov-Dec;45(2-4):337-51
3319232
Experientia. 1963 Feb 15;19:96-7
13967892
J Biol Chem. 1974 Nov 25;249(22):7130-9
4436300
Indian J Biochem Biophys. 1984 Apr;21(2):130-2
6490072
Anal Biochem. 1972 Jun;47(2):389-94
4556490