Thio FCMA intermediates as strong acyl donors: a general solution to the formation of complex amide bonds.
Novel methodology for the formation of amide bonds under neutral conditions is described. Evidence is presented that the active acyl donors are thio FCMA intermediates, generated from the reactions of thioacids with isonitriles.
Rao
Yu
Y
Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, New York 10065, USA.
Li
Xuechen
X
Danishefsky
Samuel J
SJ
D000577:Amides / Q000737:chemistry*; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry; D013457:Sulfur Compounds / Q000737:chemistry
D000577:Amides; D009570:Nitriles; D013457:Sulfur Compounds
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