title: Severe hospital-acquired pneumonia: a review for clinicians.
abstract: Hospital-acquired pneumonia (HAP) is one of the most commonly encountered nosocomial infections. Patients who develop severe HAP experience considerable morbidity and mortality, and the condition results in a substantial expenditure of health care resources. A large body of scientific literature about HAP now exists. This article summarizes the current state of knowledge concerning severe HAP with an emphasis on recent advances in its diagnosis, treatment, and prevention.
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, Campus Box 8052, 660 South Euclid Avenue, St. Louis, MO 63110, USA.
authors.forename: John
authors.initials: J
authors.lastname: Dallas
authors.forename: Marin
authors.initials: M
authors.lastname: Kollef
references.citation: Curr Opin Crit Care. 2008 Aug;14(4):390-6
references.pmid: 18614901
references.citation: Respir Med. 2008 Mar;102(3):407-12
references.pmid: 18060758
references.citation: Infect Control Hosp Epidemiol. 2007 Jul;28(7):825-31
references.pmid: 17564985
references.citation: Crit Care. 2008;12(2):R56
references.pmid: 18426596
references.citation: Semin Respir Crit Care Med. 2009 Feb;30(1):3-9
references.pmid: 19199181
references.citation: Anesthesiology. 2009 Mar;110(3):673-80
references.pmid: 19212256
references.citation: JAMA. 2003 Nov 19;290(19):2588-98
references.pmid: 14625336
references.citation: Chest. 2008 Aug;134(2):281-287
references.pmid: 18682456
references.citation: Chest. 2006 Sep;130(3):787-93
references.pmid: 16963676
references.citation: Intensive Care Med. 2008 Oct;34(10):1779-87
references.pmid: 18592210
references.citation: Infect Control Hosp Epidemiol. 2008 Oct;29 Suppl 1:S31-40
references.pmid: 18840087
references.citation: Infect Control Hosp Epidemiol. 2008 Oct;29(10):933-40
references.pmid: 18715152
references.citation: J Crit Care. 2008 Mar;23(1):11-7
references.pmid: 18359416
references.citation: Lancet. 2001 Jul 14;358(9276):135-8
references.pmid: 11463434
references.citation: Chest. 2009 Feb;135(2):521-528
references.pmid: 18812452
references.citation: Crit Care Med. 2009 Jan;37(1):159-66
references.pmid: 19050600
references.citation: J Crit Care. 2008 Mar;23(1):138-47
references.pmid: 18359431
references.citation: Curr Opin Crit Care. 2008 Oct;14(5):605-8
references.pmid: 18787457
references.citation: Am J Respir Crit Care Med. 2006 Jul 1;174(1):84-93
references.pmid: 16603606
references.citation: Ann Intern Med. 2009 Jan 6;150(1):19-26
references.pmid: 19124816
references.citation: Crit Care Med. 2009 Jan;37(1):111-8
references.pmid: 19050618
references.citation: Am J Infect Control. 2008 May;36(4 Suppl):S83-92
references.pmid: 18468550
references.citation: Crit Care. 2008;12(3):R62
references.pmid: 18454864
references.citation: J Antimicrob Chemother. 2008 Jul;62(1):5-34
references.pmid: 18445577
references.citation: Eur Respir J. 2007 Aug;30(2):314-20
references.pmid: 16870667
references.citation: Infect Control Hosp Epidemiol. 2009 Apr;30(4):319-24
references.pmid: 19245314
references.citation: J Intensive Care Med. 2009 Jan-Feb;24(1):26-34
references.pmid: 19019839
references.citation: Am J Respir Crit Care Med. 2002 Apr 1;165(7):867-903
references.pmid: 11934711
references.citation: J Infect. 2008 May;56(5):319-25
references.pmid: 18405975
references.citation: Chest. 2008 Nov;134(5):938-946
references.pmid: 18641114
references.citation: N Engl J Med. 2009 Jan 1;360(1):20-31
references.pmid: 19118302
references.citation: BMJ. 2005 May 28;330(7502):1243
references.pmid: 15901643
references.citation: Am J Med. 2005 Jan;118(1):11-8
references.pmid: 15639202
references.citation: Chest. 2004 May;125(5):1791-9
references.pmid: 15136392
references.citation: Intensive Care Med. 2009 Jan;35(1):9-29
references.pmid: 18989656
references.citation: Am J Respir Crit Care Med. 2001 May;163(6):1371-5
references.pmid: 11371403
references.citation: Crit Care Med. 2009 Mar;37(3):1062-7
references.pmid: 19237918
references.citation: J Crit Care. 2008 Mar;23(1):82-90
references.pmid: 18359425
references.citation: Chest. 2005 Oct;128(4):2706-13
references.pmid: 16236946
references.citation: Curr Opin Infect Dis. 2007 Apr;20(2):190-7
references.pmid: 17496579
references.citation: Infect Control Hosp Epidemiol. 2007 Apr;28(4):466-72
references.pmid: 17385154
references.citation: Thorax. 2009 Jun;64(6):516-22
references.pmid: 19213771
references.citation: Crit Care Med. 2008 Jul;36(7):2008-13
references.pmid: 18552684
references.citation: Crit Care Med. 2005 Oct;33(10):2184-93
references.pmid: 16215368
references.citation: Intensive Care Med. 2007 Jan;33(1):137-42
references.pmid: 17115135
references.citation: J Crit Care. 2008 Mar;23(1):126-37
references.pmid: 18359430
references.citation: JAMA. 2008 Aug 20;300(7):805-13
references.pmid: 18714060
references.citation: Curr Opin Infect Dis. 2009 Apr;22(2):159-66
references.pmid: 19276975