title: Utilization study of filgrastim (Neutromax) during autologous haematopoietic precursor transplantation for myeloma and lymphoma patients.
abstract: To describe utilization of a biosimilar product containing filgrastim (Neutromax), data of 414 myeloma or lymphoma patients subjected to autologous SCT between 1998 and 2007 were analyzed. Filgrastim was used for mobilization of progenitors (5 days at 300 microg/day) and for the recovery of neutropenia after transplantation (100 microg/day, since day +5). In 2003, the excipient mannitol was replaced by sorbitol. A mean dose of 9.47 x 10(6)CD34(+)cells/kg was infused; 100 neutrophils/mm(3) required 5-day treatment; 500 neutrophils/mm(3), 6 days and 1000 neutrophils/mm(3), 7 days. Neutromax effect in SCT is similar to reports with other brands. No difference was found between formulations.
authors.affiliation: Bio Sidus S.A., Constitución 4234, 1254 Buenos Aires, Argentina. h.ferro@biosidus.com.ar
authors.forename: Hugo H
authors.initials: HH
authors.lastname: Ferro
authors.forename: Mariana
authors.initials: M
authors.lastname: Juni
authors.forename: Ricardo
authors.initials: R
authors.lastname: Bello
authors.forename: Alejandro
authors.initials: A
authors.lastname: Vidal
authors.forename: Roberto A
authors.initials: RA
authors.lastname: Diez
authors.forename: Santiago
authors.initials: S
authors.lastname: Pavlovsky
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005260:Female; D000069585:Filgrastim; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage*; D019650:Hematopoietic Stem Cell Mobilization / Q000379:methods*; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D008223:Lymphoma / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000628:therapy*; D009503:Neutropenia / Q000188:drug therapy*; D011446:Prospective Studies; D011994:Recombinant Proteins; D019172:Transplantation Conditioning; D055815:Young Adult
chemical_list: D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; D000069585:Filgrastim