Hepatoprotective and antioxidant activity of two iridoids from Mussaenda 'dona aurora'.
Mussaenda 'dona aurora' (sepals) has been investigated for its hepatoprotective and antioxidant activities. The highest activity was observed in the ethyl acetate fraction. The separation of the ethyl acetate fraction gave two iridoids, sanshiside-D and lamalbide. Sanshiside-D exhibited a hepatoprotective activity greater than silimarin as was evidenced by significant reduction of ALT and AST in the serum enzyme levels.
Vidyalakshmi
Kandulva Sethuraman
KS
Department of Chemistry, SASTRA University, Thanjavur, Tamilnadu, India. vidyakumbak@yahoo.co.in
Nagarajan
Sulochana
S
Vasanthi
Hannah Rachel
HR
Venkappaya
Rajamanickam
Victor
V
D000818:Animals; D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology; D002252:Carbon Tetrachloride Poisoning / Q000188:drug therapy; D005260:Female; D035264:Flowers / Q000737:chemistry*; D016166:Free Radical Scavengers / Q000302:isolation & purification / Q000494:pharmacology; D039823:Iridoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology* / Q000627:therapeutic use; D008099:Liver / Q000187:drug effects / Q000473:pathology*; D008297:Male; D051379:Mice; D008958:Models, Molecular; D010936:Plant Extracts / Q000737:chemistry; D019666:Rubiaceae / Q000737:chemistry*
D000975:Antioxidants; D016166:Free Radical Scavengers; D039823:Iridoids; D010936:Plant Extracts