title: Treatment of focal epithelial hyperplasia with topical imiquimod: report of three cases.
abstract: Focal epithelial hyperplasia (Heck disease) is a rare disorder caused by specific types of HPV. It mainly involves oral mucosa and children are affected more frequently. It may persist for years, producing a significant reduction in quality of life. Several treatment modalities such as surgical excision, laser ablation, cryotherapy, electrocauterization, topical, intralesional, systemic interferon, and systemic retinoic acid have been used with inconsistent results and many side effects. Here we report three children of Turkish origin with focal epithelial hyperplasia successfully treated with imiquimod 5% cream. No serious side effects were observed and recurrence did not occur during the 1-year follow-up period.
authors.affiliation: Dermatology Department, Haydarpaşa Numune Training and Research Hospital, Istanbul, Turkey. drsirin@gmail.com
authors.forename: Sirin
authors.initials: S
authors.lastname: Yasar
authors.forename: Ayse Tulin
authors.initials: AT
authors.lastname: Mansur
authors.forename: Zehra Asiran
authors.initials: ZA
authors.lastname: Serdar
authors.forename: Fatih
authors.initials: F
authors.lastname: Goktay
authors.forename: Canan
authors.initials: C
authors.lastname: Aslan
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage* / Q000009:adverse effects; D000287:Administration, Topical; D000293:Adolescent; D000634:Aminoquinolines / Q000008:administration & dosage* / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D005260:Female; D017573:Focal Epithelial Hyperplasia / Q000188:drug therapy* / Q000473:pathology; D005500:Follow-Up Studies; D006801:Humans; D000077271:Imiquimod; D016896:Treatment Outcome
chemical_list: D000276:Adjuvants, Immunologic; D000634:Aminoquinolines; D000077271:Imiquimod