Telomerase deficiency affects normal brain functions in mice.
Telomerase maintains telomere structures and chromosome stability, and it is essential for preserving the characteristics of stem and progenitor cells. In the brain, the hippocampus and the olfactory bulbs are continuously supplied with neural stem and progenitor cells that are required for adult neurogenesis throughout the life. Therefore, we examined whether telomerase plays important roles in maintaining normal brain functions in vivo. Telomerase reverse transcriptase (TERT) expression was observed in the hippocampus, the olfactory bulbs, and the cerebellum, but the telomerase RNA component (TERC) was not detected in hippocampus and olfactory bulbs. Interestingly, TERT-deficient mice exhibited significantly altered anxiety-like behaviors and abnormal olfaction measuring the functions of the hippocampus and the olfactory bulbs, respectively. However, the cerebellum-dependent behavior was not changed in these mutant mice. These results suggest that TERT is constitutively expressed in the hippocampus and the olfactory bulbs, and that it is important for regulating normal brain functions.
Lee
Jaehoon
J
Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon 440-746, Korea.
Jo
Yong Sang
YS
Sung
Young Hoon
YH
Hwang
In Koo
IK
Kim
Hyuk
H
Kim
Song-Yi
SY
Yi
Sun Shin
SS
Choi
June-Seek
JS
Sun
Woong
W
Seong
Je Kyung
JK
Lee
Han-Woong
HW
D000375:Aging / Q000502:physiology; D000818:Animals; D001007:Anxiety / Q000503:physiopathology; D001522:Behavior, Animal; D001921:Brain / Q000254:growth & development; D002531:Cerebellum / Q000378:metabolism; D005333:Fetus; D006624:Hippocampus / Q000378:metabolism*; D008099:Liver / Q000196:embryology; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D009043:Motor Activity / Q000502:physiology; D009830:Olfactory Bulb / Q000378:metabolism*; D055696:Olfactory Perception / Q000235:genetics; D012313:RNA / Q000378:metabolism; D051381:Rats; D019098:Telomerase / Q000172:deficiency* / Q000235:genetics / Q000378:metabolism; D016615:Telomere / Q000378:metabolism; D013950:Thymus Gland / Q000196:embryology
C422952:telomerase RNA; D012313:RNA; D019098:Telomerase; C509187:Tert protein, mouse
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