Molecular insights into farm animal and zoonotic Salmonella infections.
Salmonella enterica is a facultative intracellular pathogen of worldwide importance. Infections may present in a variety of ways, from asymptomatic colonization to inflammatory diarrhoea or typhoid fever depending on serovar- and host-specific factors. Human diarrhoeal infections are frequently acquired via the food chain and farm environment by virtue of the ability of selected non-typhoidal serovars to colonize the intestines of food-producing animals and contaminate the avian reproductive tract and egg. Colonization of reservoir hosts often occurs in the absence of clinical symptoms; however, some S. enterica serovars threaten animal health owing to their ability to cause acute enteritis or translocate from the intestines to other organs causing fever, septicaemia and abortion. Despite the availability of complete genome sequences of isolates representing several serovars, the molecular mechanisms underlying Salmonella colonization, pathogenesis and transmission in reservoir hosts remain ill-defined. Here we review current knowledge of the bacterial factors influencing colonization of food-producing animals by Salmonella and the basis of host range, differential virulence and zoonotic potential.
Stevens
Mark P
MP
Division of Microbiology, Institute for Animal Health, Compton, Berkshire RG20 7NN, UK. mark-p.stevens@bbsrc.ac.uk
Humphrey
Tom J
TJ
Maskell
Duncan J
DJ
D000818:Animals; D000829:Animals, Domestic; D004197:Disease Reservoirs / Q000382:microbiology / Q000662:veterinary*; D006801:Humans; D012481:Salmonella Infections, Animal / Q000191:economics / Q000382:microbiology*; D019779:Salmonella enterica / Q000235:genetics / Q000276:immunology / Q000502:physiology*; D037521:Virulence Factors / Q000235:genetics / Q000276:immunology; D015047:Zoonoses / Q000382:microbiology*
D037521:Virulence Factors
Infect Immun. 2005 Sep;73(9):5438-49
16113260
Cell Microbiol. 2001 Dec;3(12):825-37
11736994
Infect Immun. 2005 Apr;73(4):2344-50
15784580
Science. 2008 Aug 22;321(5892):1078-80
18719281
Cell Microbiol. 2008 May;10(5):1166-80
18241212
PLoS One. 2008;3(12):e3829
19050757
Vet Microbiol. 2005 Jan 31;105(2):93-101
15627520
Nucleic Acids Res. 2005 Mar 21;33(5):1690-8
15781495
J Food Prot. 2007 Aug;70(8):1937-9
17803153
Avian Pathol. 2008 Aug;37(4):399-406
18622856
J Clin Microbiol. 2008 Apr;46(4):1330-6
18272702
Infect Immun. 2008 Mar;76(3):907-15
18160481
BMC Genomics. 2008 Oct 06;9:458
18837991
EMBO J. 2005 Jun 1;24(11):2043-52
15889142
Avian Dis. 1993 Jan-Mar;37(1):189-93
8452495
Mol Microbiol. 2005 Jul;57(1):196-211
15948960
Epidemiol Infect. 1998 Oct;121(2):295-301
9825780
Microb Pathog. 2000 Feb;28(2):59-70
10644492
Microbiology (Reading). 1999 Sep;145 ( Pt 9):2431-2441
10517596
Infect Immun. 2007 Mar;75(3):1524-33
17220313
Cell Microbiol. 2008 Apr;10(4):876-90
18034866
Antimicrob Agents Chemother. 2007 Jul;51(7):2631-5
17502403
Infect Immun. 2003 Mar;71(3):1116-24
12595422
Nature. 2007 Nov 29;450(7170):725-30
18046412
J Exp Med. 2006 Jun 12;203(6):1591-601
16754724
Cell Microbiol. 2000 Aug;2(4):293-303
11207586
Mol Microbiol. 2002 Feb;43(4):895-905
11929540
Poult Sci. 2002 Nov;81(11):1653-60
12455592
Proc Natl Acad Sci U S A. 1999 Aug 17;96(17):9845-50
10449782
Avian Pathol. 2004 Jun;33(3):314-20
15223560
Vet Microbiol. 2008 Jan 1;126(1-3):216-24
17689891
Microb Pathog. 2008 Apr;44(4):271-8
17997077
Infect Immun. 1995 Jul;63(7):2743-54
7790093
FEMS Microbiol Lett. 2002 Dec 17;217(2):243-7
12480111
Cell Microbiol. 2005 Jul;7(7):901-9
15953023
Clin Infect Dis. 2004 Apr 15;38 Suppl 3:S127-34
15095181
Vet J. 2008 Jan;175(1):82-8
17324598
Mol Microbiol. 2003 Jun;48(5):1357-76
12787362
Infect Immun. 2002 Dec;70(12):6788-97
12438354
J Immunol. 2002 Sep 15;169(6):2846-50
12218096
Vet Microbiol. 2003 Mar 20;92(1-2):49-64
12488070
Infect Immun. 2000 Jun;68(6):3768-71
10816545
Infect Immun. 2007 Nov;75(11):5191-9
17724072
Microbiology (Reading). 2005 Dec;151(Pt 12):3957-3968
16339940
EcoSal Plus. 2005 Nov;1(2):
26443521
Proc Natl Acad Sci U S A. 2004 May 11;101(19):7421-6
15123795
Innate Immun. 2008 Aug;14(4):223-31
18669608
Nat Immunol. 2004 Jan;5(1):104-12
14691478
Infect Immun. 1998 Apr;66(4):1432-8
9529064
Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10420-10425
16803956
Zentralbl Veterinarmed B. 1995 Oct;42(8):459-69
8578920
Infect Immun. 2005 Nov;73(11):7161-9
16239510
Appl Environ Microbiol. 2006 Feb;72(2):1055-64
16461649
Bull World Health Organ. 2004 May;82(5):346-53
15298225
Science. 2004 Nov 5;306(5698):1040-2
15528446
J Leukoc Biol. 2006 Feb;79(2):268-76
16330534
Expert Rev Mol Med. 2007 Jul 02;9(18):1-17
17605831
Infect Immun. 2005 Dec;73(12):7894-905
16299280
Curr Issues Intest Microbiol. 2006 Sep;7(2):65-71
16875421
EMBO J. 1999 Jul 15;18(14):3924-33
10406797
Vet Microbiol. 2006 Jun 15;115(1-3):284-90
16549278
Vet Immunol Immunopathol. 2002 Sep 25;88(3-4):183-96
12127416
Appl Environ Microbiol. 1998 Jun;64(6):2166-72
9603830
Microbiology (Reading). 2000 Jul;146 ( Pt 7):1639-1649
10878128
J Bacteriol. 2004 Sep;186(17):5883-98
15317794
Nature. 1999 Oct 21;401(6755):804-8
10548107
Cell Microbiol. 2000 Jun;2(3):239-50
11207580
J Med Microbiol. 2004 Jun;53(Pt 6):539-543
15150335
Infect Immun. 2001 May;69(5):3092-9
11292728
Infect Immun. 2002 Jul;70(7):3843-55
12065528
PLoS Biol. 2007 Oct;5(10):2177-89
17760501
Infect Immun. 1999 Dec;67(12):6385-93
10569754
Proc Natl Acad Sci U S A. 1996 Mar 19;93(6):2593-7
8637919
Science. 2000 Mar 3;287(5458):1655-8
10698741
Avian Dis. 2003 Jul-Sep;47(3):633-9
14562891
Anim Genet. 2009 Dec;40(6):871-7
20597881
Am J Vet Res. 1999 Sep;60(9):1155-8
10490088
Infect Immun. 2008 Nov;76(11):4924-33
18765734
Adv Exp Med Biol. 2008;631:7-21
18792679
Infect Immun. 2007 Aug;75(8):3950-60
17548482
Cell Microbiol. 2009 Mar;11(3):475-87
19046340
PLoS Pathog. 2008 Apr 04;4(4):e1000036
18389060
Immunogenetics. 2001 Dec;53(9):786-91
11862411
Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14057-9
9826652
BMC Microbiol. 2008 Dec 18;8:228
19091138
Infect Immun. 1995 Jul;63(7):2755-61
7790094
Epidemiol Infect. 2000 Oct;125(2):229-55
11117946
FEMS Microbiol Rev. 2009 Jul;33(4):718-38
19207743
Cell Microbiol. 2006 Dec;8(12):1946-57
16869830
Res Vet Sci. 2004 Jun;76(3):165-9
15046948
Infect Immun. 1998 Dec;66(12):5799-804
9826357
J Cell Sci. 2004 Nov 15;117(Pt 24):5771-80
15507487
Infect Immun. 2005 May;73(5):2986-90
15845505
Zoonoses Public Health. 2009 Apr;56(3):145-9
18990194
Avian Dis. 1997 Jul-Sep;41(3):559-67
9356700
Infect Immun. 1998 May;66(5):2099-106
9573095
BMC Microbiol. 2009 Feb 23;9:42
19236707
Trends Microbiol. 2008 Mar;16(3):107-14
18280160
Cell Microbiol. 2007 Jul;9(7):1834-50
17388786
Microbes Infect. 2006 Nov-Dec;8(14-15):2899-907
17113332
Vet Microbiol. 2003 May 29;93(3):223-33
12695046
Cell Microbiol. 2008 Nov;10(11):2364-76
18671822
Science. 1995 Jul 21;269(5222):400-3
7618105
Avian Dis. 1997 Jul-Sep;41(3):535-9
9356697
Environ Microbiol. 2001 Jul;3(7):421-30
11553232
PLoS One. 2008 May 14;3(5):e2178
18478101
Nature. 2008 May 29;453(7195):620-5
18509436
Vaccine. 2006 May 1;24(18):3840-4
16154248
Epidemiol Infect. 1989 Dec;103(3):415-23
2691262
Clin Microbiol Infect. 2005 Feb;11(2):138-44
15679488
J Infect. 2008 Jun;56(6):413-22
18474400
PLoS Pathog. 2006 Feb;2(2):e11
16518469
Antimicrob Agents Chemother. 2007 Aug;51(8):2867-76
17548496
Infect Immun. 2003 May;71(5):2839-58
12704158
Infect Immun. 2003 Dec;71(12):6734-41
14638758
J Food Prot. 2002 Feb;65(2):280-3
11848558
Nat Rev Microbiol. 2008 Dec;6(12):883-92
18955984
Appl Environ Microbiol. 2004 May;70(5):2756-63
15128529
Br Poult Sci. 2006 Aug;47(4):379-91
16905463
Vet Pathol. 1997 Sep;34(5):369-86
9381648
Infect Immun. 1995 Jul;63(7):2443-9
7790055
Int J Med Microbiol. 2008 Jul;298(5-6):429-39
17888732
Infect Immun. 2001 Sep;69(9):5619-25
11500437
Genome Res. 2008 Oct;18(10):1624-37
18583645
Infect Immun. 2003 Nov;71(11):6446-52
14573666
Avian Dis. 2000 Jul-Sep;44(3):706-10
11007024
Appl Environ Microbiol. 2008 Nov;74(21):6616-22
18776023
J Appl Microbiol. 2004;96(4):750-60
15012813
Cell Microbiol. 2008 Jan;10(1):247-61
17725646
PLoS Pathog. 2008 Apr 04;4(4):e1000037
18389058
Microbiology (Reading). 2007 Jun;153(Pt 6):1940-1952
17526851
Curr Opin Microbiol. 2006 Feb;9(1):46-54
16406778
Infect Immun. 2008 Jan;76(1):403-16
17967858
Infect Immun. 1997 May;65(5):1786-92
9125562
J Exp Med. 2002 May 6;195(9):1155-66
11994420
Infect Immun. 1998 Jun;66(6):2803-8
9596751
J Bacteriol. 2005 Sep;187(18):6545-55
16159788
Mol Microbiol. 1996 Oct;22(2):327-38
8930917
Res Vet Sci. 1978 Sep;25(2):139-43
364573
Proc Natl Acad Sci U S A. 2005 Nov 29;102(48):17460-5
16301528
Microbiology (Reading). 2004 Apr;150(Pt 4):1063-1071
15073315
Infect Immun. 1999 Feb;67(2):608-17
9916066
Infect Immun. 2008 Nov;76(11):5310-21
18794283
Infect Immun. 2001 Jan;69(1):367-77
11119526
BMC Microbiol. 2009 Jan 06;9:3
19126220
Appl Environ Microbiol. 2008 Mar;74(6):1757-66
18245251
Infect Immun. 2000 Jun;68(6):3744-7
10816540
Environ Microbiol. 2001 May;3(5):332-42
11422320
Infect Immun. 2002 May;70(5):2249-55
11953356
Mol Microbiol. 2006 Nov;62(3):786-93
17076670
Appl Environ Microbiol. 2005 Aug;71(8):4388-99
16085829
J Bacteriol. 2008 May;190(9):3393-8
18310344
Cell Microbiol. 2006 May;8(5):728-37
16611223
Mol Microbiol. 2004 Nov;54(4):994-1010
15522082
Infect Immun. 2007 Sep;75(9):4342-50
17591794
Infect Immun. 2005 Dec;73(12):7817-26
16299271