title: Potential of adult neural stem cells for cellular therapy.
abstract: Cellular therapy is the replacement of unhealthy or damaged cells or tissues by new ones. Because neurodegenerative diseases, cerebral strokes, and traumatic injuries to the central nervous system (CNS) produce neurological deficits that result from neuronal loss, cell therapy is a prominent area of investigation for the treatment of neurological diseases and injuries. Neural progenitor and stem cells generate the main phenotyes of the nervous system, and offer a model of choice for cellular therapy in the CNS. With the confirmation that neurogenesis occurs in the adult brain, and the recent isolation and characterization in vitro of neural progenitor and stem cells from the adult CNS, new strategies are being devised and have the potential to treat a broad range of CNS diseases and injuries.
authors.affiliation: National Neuroscience Institute, Singapore, Singapore.
authors.forename: Philippe
authors.initials: P
authors.lastname: Taupin
references.citation: Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7925-30
references.pmid: 12792021
references.citation: Nature. 2001 May 3;411(6833):42-3
references.pmid: 11333968
references.citation: Stroke. 2001 May;32(5):1201-7
references.pmid: 11340234
references.citation: Neurosci Lett. 2001 Oct 26;312(3):173-6
references.pmid: 11602338
references.citation: Nature. 2003 Apr 17;422(6933):688-94
references.pmid: 12700753
references.citation: Mol Cell Neurosci. 2004 Nov;27(3):322-31
references.pmid: 15519246
references.citation: Nat Biotechnol. 2002 Nov;20(11):1103-10
references.pmid: 12379867
references.citation: Nature. 1996 Oct 17;383(6601):624-7
references.pmid: 8857538
references.citation: Cell Mol Biol (Noisy-le-grand). 2002 Sep;48(6):717-23
references.pmid: 12396084
references.citation: J Pediatr Surg. 2007 Jan;42(1):48-53
references.pmid: 17208540
references.citation: Stroke. 2007 Jul;38(7):2165-72
references.pmid: 17510456
references.citation: Stroke. 2001 Apr;32(4):1012-9
references.pmid: 11283405
references.citation: Science. 2000 Feb 25;287(5457):1427-30
references.pmid: 10688781
references.citation: Hum Gene Ther. 2003 Dec 10;14(18):1777-85
references.pmid: 14670128
references.citation: Neurosci Lett. 2004 Aug 19;366(3):287-91
references.pmid: 15288436
references.citation: J Neurosci. 2000 Dec 1;20(23):8727-35
references.pmid: 11102479
references.citation: Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):14069-74
references.pmid: 16172374
references.citation: Clin Cancer Res. 2006 Sep 15;12(18):5550-6
references.pmid: 17000692
references.citation: Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12846-51
references.pmid: 11070094
references.citation: Eur J Neurosci. 2001 Jul;14(1):10-8
references.pmid: 11488944
references.citation: Eur J Neurosci. 2001 Sep;14(6):937-45
references.pmid: 11595032
references.citation: J Neurosci. 2002 Aug 1;22(15):6639-49
references.pmid: 12151543
references.citation: Mol Cell Neurosci. 2003 Sep;24(1):171-89
references.pmid: 14550778
references.citation: Brain Res. 2001 Jan 26;890(1):11-22
references.pmid: 11164764
references.citation: Brain Res. 2007 Apr 6;1140:195-204
references.pmid: 17289003
references.citation: Neuroscience. 2005;132(3):767-76
references.pmid: 15837137
references.citation: J Neurosci. 1992 Jan;12(1):249-56
references.pmid: 1729437
references.citation: J Neurol Sci. 2002 Jan 15;193(2):137-46
references.pmid: 11790394
references.citation: Neuroscience. 2004;127(2):319-32
references.pmid: 15262322
references.citation: J Neurosci Res. 2003 Dec 15;74(6):838-51
references.pmid: 14648588
references.citation: J Neurosci. 1996 Apr 15;16(8):2649-58
references.pmid: 8786441
references.citation: J Neurosci. 1998 May 15;18(10):3659-68
references.pmid: 9570797
references.citation: Proc Natl Acad Sci U S A. 1995 Dec 5;92(25):11879-83
references.pmid: 8524867
references.citation: Exp Neurol. 2003 Jun;181(2):115-29
references.pmid: 12781986
references.citation: Brain Res. 2005 May 31;1045(1-2):206-16
references.pmid: 15910779
references.citation: Nat Biotechnol. 2002 Nov;20(11):1111-7
references.pmid: 12379868
references.citation: Neuroimage. 2004 Jan;21(1):311-7
references.pmid: 14741669
references.citation: Neurosci Lett. 2002 Jan 25;318(2):81-4
references.pmid: 11796191
references.citation: Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):9023-7
references.pmid: 12853570
references.citation: J Comp Neurol. 2004 Nov 29;480(1):101-14
references.pmid: 15514921
references.citation: Exp Brain Res. 2003 Jul;151(2):204-17
references.pmid: 12783147
references.citation: J Neurosci Res. 2004 May 15;76(4):453-65
references.pmid: 15114617
references.citation: J Neurosci. 1993 Sep;13(9):3848-63
references.pmid: 8366349
references.citation: J Neurosci. 1999 Jul 15;19(14):6006-16
references.pmid: 10407038
references.citation: J Neurosci Res. 2002 Sep 15;69(6):745-9
references.pmid: 12205667
references.citation: Nat Med. 1998 Nov;4(11):1313-7
references.pmid: 9809557
references.citation: Eur J Neurosci. 2004 Oct;20(7):1695-704
references.pmid: 15379990
references.citation: Exp Neurol. 2001 Jan;167(1):27-39
references.pmid: 11161590
references.citation: J Neurosci. 2002 Apr 1;22(7):2679-89
references.pmid: 11923433
references.citation: Science. 2000 Feb 25;287(5457):1433-8
references.pmid: 10688783
references.citation: J Neurosci. 2000 Mar 15;20(6):2218-28
references.pmid: 10704497
references.citation: Science. 2007 Mar 2;315(5816):1243-9
references.pmid: 17303719
references.citation: J Comp Neurol. 2000 Jul 17;423(1):1-12
references.pmid: 10861532
references.citation: Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14686-91
references.pmid: 11121069
references.citation: J Neurosci. 2004 Nov 24;24(47):10642-51
references.pmid: 15564580
references.citation: Nature. 2005 Jul 14;436(7048):266-71
references.pmid: 16015332
references.citation: Proc Natl Acad Sci U S A. 2004 Jul 6;101(27):10177-82
references.pmid: 15210991
references.citation: J Comp Neurol. 2001 Jul 9;435(4):406-17
references.pmid: 11406822
references.citation: Neuroscience. 2001;105(1):33-41
references.pmid: 11483298
references.citation: Neuroscience. 2003;116(2):373-82
references.pmid: 12559093
references.citation: J Neurosci. 1997 Aug 1;17(15):5820-9
references.pmid: 9221780
references.citation: Neurosurgery. 2005;56(1):163-71; discussion 171
references.pmid: 15617599
references.citation: J Neurosci. 2005 Mar 9;25(10):2637-46
references.pmid: 15758174
references.citation: Nat Rev Neurosci. 2000 Oct;1(1):67-73
references.pmid: 11252770
references.citation: Ann Neurol. 2002 Dec;52(6):802-13
references.pmid: 12447935
references.citation: Nat Med. 2002 Sep;8(9):963-70
references.pmid: 12161747
references.citation: Eur J Neurosci. 2002 Sep;16(6):1045-57
references.pmid: 12383233