title: Comparison of viscoelastic coagulation analysis and standard coagulation profiles in critically ill neonatal foals to outcome.
abstract: OBJECTIVE
  To determine if changes in viscoelastic variables are associated with abnormalities observed in the standard coagulation profile and patient outcome in foals with suspected septicemia.
  
  
  METHODS
  Prospective clinical trial during 2003 and 2004 foal season.
  
  
  METHODS
  Neonatal intensive care unit at a veterinary teaching hospital.
  
  
  METHODS
  Thirty critically ill foals <72-hour-old admitted sequentially meeting criteria for systemic inflammatory response associated with infection.
  
  
  METHODS
  Hemostatic evaluation, using standard coagulation testing and viscoelastic analysis, was performed at admission, 24 hours following admission, and 48 hours following admission in critically ill foals. Standard coagulation tests included platelet count, prothrombin time, activated partial thromboplastin time, fibrinogen, fibrin(ogen) degradation products, and antithrombin. Data collected from viscoelastic analysis included time to initial clot formation (ACT), clot rate, and platelet function. Signalment, blood culture results, clinicopathologic data, and outcome were collected from medical records. Equality of populations test was used to determine associations between coagulation tests and blood culture status/outcome, as well as between viscoelastic parameters and coagulopathy, blood culture status, and outcome. Logistic regression was used to quantify associations. A significance level of P<0.05 was used.
  
  
  RESULTS
  Foals with decreasing clot rate (CR) over the sample period were more likely to be euthanized or die (P=0.02). Foals with prolonged ACT (P=0.03), and decreased CR at admission (P=0.047), were more commonly coagulopathic. Identification of coagulopathy on admission (P=0.02), or persistence of hemostatic dysfunction 48 hours later (P=0.04), was associated with death.
  
  
  CONCLUSIONS
  Viscoelastic coagulation evaluation could be used in a neonatal intensive care unit setting to further characterize coagulopathy, and identify foals at higher risk for poor outcome.
authors.affiliation: Department of Clinical Studies, University of Pennsylvania, Philadelphia, PA 19348, USA. bldallap@vet.upenn.edu
authors.forename: Barbara L
authors.initials: BL
authors.lastname: Dallap Schaer
authors.forename: Amy I
authors.initials: AI
authors.lastname: Bentz
authors.forename: Raymond C
authors.initials: RC
authors.lastname: Boston
authors.forename: Jonathan E
authors.initials: JE
authors.lastname: Palmer
authors.forename: Pamela A
authors.initials: PA
authors.lastname: Wilkins
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001777:Blood Coagulation / Q000502:physiology*; D016638:Critical Illness; D005260:Female; D006734:Horse Diseases / Q000097:blood*; D006736:Horses; D008297:Male; D018805:Sepsis / Q000097:blood / Q000662:veterinary*; D018746:Systemic Inflammatory Response Syndrome / Q000097:blood / Q000662:veterinary*; D013916:Thrombelastography / Q000662:veterinary*