title: Combined hepatocellular and cholangiocellular carcinoma presenting with radiological characteristics of focal nodular hyperplasia.
abstract: Combined hepatocellular and cholangiocellular carcinoma (cHCC-CC) is a rare tumor type containing unequivocal elements of both hepatocellular carcinoma and cholangiocarcinoma that are intimately mixed. Although these tumors are usually considered to be more related to hepatocellular carcinoma than to cholangiocarcinoma, they sometimes, in contrast to hepatocellular carcinoma, contain a significant amount of fibrous stroma. This might in some cases explain atypical radiological features. We report a case of a cHCC-CC in a 47-year-old female that resembled focal nodular hyperplasia on Magnetic Resonance Imaging. Correlation of imaging and serum levels of alpha-fetoprotein and CA19.9 can help to make the correct diagnosis preoperatively.
authors.affiliation: Department of Radiology, UZ Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium. inneke.willekens@gmail.com
authors.forename: Inneke
authors.initials: I
authors.lastname: Willekens
authors.forename: Anne
authors.initials: A
authors.lastname: Hoorens
authors.forename: Caroline
authors.initials: C
authors.lastname: Geers
authors.forename: Bart
authors.initials: B
authors.lastname: Op de Beeck
authors.forename: Frederik
authors.initials: F
authors.lastname: Vandenbroucke
authors.forename: Johan
authors.initials: J
authors.lastname: de Mey
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology; D018281:Cholangiocarcinoma / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D020518:Focal Nodular Hyperplasia / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011859:Radiography
chemical_list: D014408:Biomarkers, Tumor
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