Understanding the specificity of receptor tyrosine kinases signaling.
Tyrosine kinase receptors (RTKs) represent a large family of transmembrane proteins,1,2 present in all metazoans, whose function is to transduce signals from the extracellular milieu to the inside of the cells. The common features of this protein family are: the extracellular domain, devoted to the binding to the specific receptor ligand, a single transmembrane region, and an intracellular chain featuring the conserved protein tyrosine kinase domain. RTKs control many aspects of cellular physiology both during development and in adult life, such as cell proliferation, migration, survival and differentiation.1.
De Donatis
Alina
A
Dipartimento di Scienze Biochimiche; Università degli Studi di Firenze; Firenze Italy.
Cirri
Paolo
P
J Biol Chem. 2008 Jul 18;283(29):19948-56
18499659
Cell. 2001 Jul 13;106(1):9-11
11461696
Proc Natl Acad Sci U S A. 2005 Feb 22;102(8):2760-5
15701692
J Biol Chem. 2004 Feb 27;279(9):8038-46
14660565
Cell. 2000 Oct 13;103(2):211-25
11057895
Int J Cancer. 2001 Mar 15;91(6):757-62
11275976
Trends Cell Biol. 2001 Dec;11(12):504-11
11719057
Mol Biol Evol. 2006 Jun;23(6):1232-41
16551648
Genes Dev. 2008 May 15;22(10):1276-312
18483217