title: Assessment of association of rs2200733 on chromosome 4q25 with atrial fibrillation and ischemic stroke in a Chinese Han population.
abstract: Atrial fibrillation (AF) is the most common arrhythmia in the clinical setting and an independent risk factor for stroke. Approximately 10 million Chinese people are affected by AF, but the genetic basis is largely unknown. A recent genome-wide association study in Iceland identified association between SNP rs2200733 on 4q25 and AF; however, many independent replication studies are essential to unequivocally validate this association. To assess the association between rs2200733 and AF as well as that between rs2200733 and ischemic stroke in a mainland Chinese Han population, we carried out case-control association studies with 383 AF patients versus 851 non-AF controls and 811 ischemic stroke patients versus 688 non-stroke controls. Highly significant association was detected between rs2200733 and AF in a Chinese Han population (allelic P = 3.7 × 10(-11) with OR = 1.81; genotypic P = 4.1 × 10(-12) with a dominant model). When the AF cases were divided into lone AF (32.6%) and other types of AF (67.4%), significantly stronger association was found with lone AF (OR = 2.40, P = 1.3 × 10(-9) compared to OR = 1.59, P = 6.2 × 10(-7) for other types of AF; P = 0.02 for two ORs). No significant association was found between rs2200733 and ischemic stroke. Our results suggest that SNP rs2200733 confers a highly significant risk of AF, but not ischemic stroke, in a more representative Chinese Han population in the mainland China.
authors.affiliation: Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Lisong
authors.initials: L
authors.lastname: Shi
authors.forename: Cong
authors.initials: C
authors.lastname: Li
authors.forename: Chuchu
authors.initials: C
authors.lastname: Wang
authors.forename: Yunlong
authors.initials: Y
authors.lastname: Xia
authors.forename: Gang
authors.initials: G
authors.lastname: Wu
authors.forename: Fan
authors.initials: F
authors.lastname: Wang
authors.forename: Chengqi
authors.initials: C
authors.lastname: Xu
authors.forename: Pengyun
authors.initials: P
authors.lastname: Wang
authors.forename: Xiuchun
authors.initials: X
authors.lastname: Li
authors.forename: Dan
authors.initials: D
authors.lastname: Wang
authors.forename: Xin
authors.initials: X
authors.lastname: Xiong
authors.forename: Ying
authors.initials: Y
authors.lastname: Bai
authors.forename: Mugen
authors.initials: M
authors.lastname: Liu
authors.forename: Jingyu
authors.initials: J
authors.lastname: Liu
authors.forename: Xiang
authors.initials: X
authors.lastname: Ren
authors.forename: Lianjun
authors.initials: L
authors.lastname: Gao
authors.forename: Binbin
authors.initials: B
authors.lastname: Wang
authors.forename: Qiutang
authors.initials: Q
authors.lastname: Zeng
authors.forename: Bo
authors.initials: B
authors.lastname: Yang
authors.forename: Xu
authors.initials: X
authors.lastname: Ma
authors.forename: Yanzong
authors.initials: Y
authors.lastname: Yang
authors.forename: Xin
authors.initials: X
authors.lastname: Tu
authors.forename: Qing Kenneth
authors.initials: QK
authors.lastname: Wang
mesh_terms: D044466:Asian People / Q000235:genetics*; D001281:Atrial Fibrillation / Q000235:genetics*; D002545:Brain Ischemia / Q000235:genetics*; D002894:Chromosomes, Human, Pair 4; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D020521:Stroke / Q000235:genetics*
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