Clinical measurement and categorization of optic disc in glaucoma patients.
BACKGROUND
Assessment of optic disc size is an important component of optic nerve head examination. Agreement between different methods of disc size measurements is not very good.


OBJECTIVE
To assess the agreement between the disc size assessed by Heidelberg retina tomograph (HRT) and stereobiomicroscopy with a 90 diopter (D) lens. To report the clinical (measured by biomicroscopy) disc diameters of small, average and large optic discs categorized by HRT disc areas.


METHODS
Observational study of subjects examined in the glaucoma clinic of a tertiary eye institute.


METHODS
Seventy-five eyes of 75 glaucoma subjects were studied. Disc diameter was measured using stereobiomicroscopy and HRT. The agreement between the two sets of measurements was assessed by intraclass correlation coefficient (ICC). Discs were classified into small (<1.6 mm(2)), average (1.6-2.6 mm(2)) and large (>2.6 mm(2)) depending on cutoffs provided by the manufacturers of HRT. The means (95% CI) of the corresponding vertical disc diameter in these groups were assessed.


METHODS
ICC, Bland and Altman plots.


RESULTS
ICC for measurements of clinical and HRT horizontal disc diameter was 0.518 and for vertical disc diameter measurement was 0.487. The mean difference between the clinical and HRT measurements as analyzed by the Bland and Altman plot was 0.17 (95% CI, 0.13- 0.47) for horizontal and 0.22 (95% CI, 0.11- 0.54) for vertical disc diameter. Of the 75 eyes, 3 eyes had small discs, 54 average and 18 large discs. The mean clinical vertical disc diameter for small discs was 1.55 mm (95% CI, 1.2-1.7), for average discs was 1.91 mm (95% CI, 1.87-1.96) and for large discs was 2.15 mm (95% CI, 2.03-2.27).


CONCLUSIONS
The agreement between clinical and HRT disc diameter measurements is moderate. Disc diameter measurement on stereobiomicroscopy can be used to categorize discs into small, average and large discs.
Rao
Harsha B Laxmana
HB
VST Glaucoma Centre, Kallam Anji Reddy Campus, L V Prasad Eye Institute, L V Prasad Marg, Banjara Hills, Hyderabad, India. harsha@lvpei.org
Sekhar
G C
GC
Babu
Ganesh J
GJ
Parikh
Rajul S
RS
D003941:Diagnostic Techniques, Ophthalmological; D005260:Female; D005901:Glaucoma / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D009898:Optic Disk / Q000473:pathology*; D009901:Optic Nerve Diseases / Q000175:diagnosis* / Q000209:etiology; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012720:Severity of Illness Index; D014054:Tomography / Q000379:methods
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