The in vitro transport of model thiodipeptide prodrugs designed to target the intestinal oligopeptide transporter, PepT1.
A thiodipeptide carrier system is shown to be effective at enabling a range of covalently bound molecules, including benzyl, benzoyl and ibuprofen conjugates, to be transported via the intestinal peptide transporter PepT1, demonstrating its potential as a rational drug delivery target.
Foley
David
D
School of Chemistry, University of Manchester, Manchester, M13 9PL, UK.
Pieri
Myrtani
M
Pettecrew
Rachel
R
Price
Richard
R
Miles
Steven
S
Miles
Stephen
S
Lam
Ho Kam
HK
Bailey
Patrick
P
Meredith
David
D
D018938:Caco-2 Cells; D004151:Dipeptides / Q000737:chemistry* / Q000378:metabolism*; D004337:Drug Carriers / Q000737:chemistry / Q000378:metabolism; D015195:Drug Design; D006801:Humans; D007422:Intestines; D000074011:Peptide Transporter 1; D011355:Prodrugs / Q000378:metabolism*; D013455:Sulfur / Q000737:chemistry*; D027981:Symporters / Q000378:metabolism*
D004151:Dipeptides; D004337:Drug Carriers; D000074011:Peptide Transporter 1; D011355:Prodrugs; D027981:Symporters; D013455:Sulfur