[Development of neointimal matrix after incorporation of modern alloplastic prostheses: comparison between ePTFE and Dacron].
BACKGROUND
In the therapy for peripheral arterial occlusive disease there remain inadequacies in the use of alloplastic material concerning thrombogenicity and biological compliance. In the 1960s, Sparks tried to combine the advantages of alloplastic prostheses with those of autologous reconstructions by using incorporated prostheses. No extensive myointimal hyperplasia was noted, but besides infections aneurysmatic dilatation were limiting factors in clinical practice.


METHODS
The incorporation of modern alloplastic prostheses without connection to circulation concerning the thickness of neointima as well as the percentage of smooth muscle cells was examined in a dog model.


RESULTS
The thickness of the neointima increased significantly in Dacron grafts with a peak on day 70 (p = 0.022), additionally a significantly greater percentage of smooth muscle cells was noted in Dacron grafts after 44 and 58 days (p = 0.008, p = 0.036).


CONCLUSIONS
Due to the decreased thickness of the incorporating matrix as well as the lower percentage of smooth muscle cells, PTFE grafts should be preferred for peripheral arterial revascularisation.
Sagban
A
A
Universitätsklinikum Düsseldorf, Klinik für Gefässchirurgie und Nierentransplantation, Düsseldorf, Deutschland.
Schiegel
E
E
Pfeiffer
T
T
Grotemeyer
D
D
Reinecke
P
P
Sandmann
W
W
Balzer
K M
KM
D000199:Actins / Q000032:analysis; D000818:Animals; D001807:Blood Vessel Prosthesis; D002196:Capillaries / Q000473:pathology; D003238:Connective Tissue / Q000473:pathology; D004285:Dogs; D005352:Fibromuscular Dysplasia / Q000473:pathology; D008856:Microscopy, Fluorescence; D011093:Polyethylene Terephthalates; D011138:Polytetrafluoroethylene; D017539:Tunica Intima / Q000473:pathology*; D014945:Wound Healing / Q000502:physiology*
C541116:ACTA2 protein, human; D000199:Actins; D011093:Polyethylene Terephthalates; D011138:Polytetrafluoroethylene