PSGL-1-dependent myeloid leukocyte activation.
Cell-cell interactions mediating leukocyte recruitment and inflammation are crucial for host defense. Leukocyte recruitment into injured tissue proceeds in a multistep process. The first contact of leukocytes with endothelial cells ("capturing" or "tethering") is mediated by selectins and their counter-receptor P-selectin glyco-protein ligand (PSGL)-1. During capture and rolling, leukocytes collect different inflammatory signals, which can activate various pathways. Integration of these signals leads to leukocyte activation, integrin-mediated arrest, cytoskeleton rearrangement, polarization, and transmigration. PSGL-1 on leukocytes also binds to activated platelets, where P-selectin is expressed at locally high site densities following alpha-granule fusion with the plasma membrane. Here, we review the signaling functions of PSGL-1 and speculate how the different known signaling events might relate to different phases of leukocyte recruitment.
Zarbock
Alexander
A
Department of Anesthesiology and Critical Care Medicine, University of Münster, Albert-Schweitzer Str. 33, 48149 Münster, Germany. zarbock@uni-muenster.de
Müller
Helena
H
Kuwano
Yoshihiro
Y
Ley
Klaus
K
D000595:Amino Acid Sequence; D000818:Animals; D001792:Blood Platelets / Q000502:physiology*; D002448:Cell Adhesion / Q000502:physiology; D002450:Cell Communication / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000503:physiopathology*; D016023:Integrins / Q000502:physiology; D036904:Leukocyte Rolling / Q000502:physiology; D007962:Leukocytes / Q000502:physiology*; D008562:Membrane Glycoproteins / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D008969:Molecular Sequence Data; D019007:P-Selectin / Q000097:blood / Q000502:physiology; D015539:Platelet Activation / Q000502:physiology*; D011499:Protein Processing, Post-Translational; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction; D013045:Species Specificity
D016023:Integrins; D008562:Membrane Glycoproteins; D019007:P-Selectin; C084882:P-selectin ligand protein