Enhancing m currents: a way out for neuropathic pain?
Almost three decades ago, the M current was identified and characterized in frog sympathetic neurons (Brown and Adams, 1980). The years following this discovery have seen a huge progress in the understanding of the function and the pharmacology of this current as well as on the structure of the underlying ion channels. Therapies for a number of syndromes involving abnormal levels of excitability in neurons are benefiting from research on M currents. At present, the potential of M current openers as analgesics for neuropathic pain is under discussion. Here we offer a critical view of existing data on the involvement of M currents in pain processing. We believe that enhancement of M currents at the site of injury may become a powerful strategy to alleviate pain in some peripheral neuropathies.
Rivera-Arconada
Ivan
I
Departamento de Fisiología, Edificio de Medicina, Universidad de Alcala Madrid, Spain.
Roza
Carolina
C
Lopez-Garcia
Jose A
JA
J Physiol. 2003 May 15;549(Pt 1):57-63
12702739
Mol Pharmacol. 2005 Apr;67(4):1009-17
15662042
Neuroreport. 2002 Apr 16;13(5):585-91
11973451
Pain. 1992 Sep;50(3):355-363
1333581
Nat Rev Neurosci. 2003 Dec;4(12):968-80
14682359
Mol Pain. 2008 Apr 18;4:14
18419827
Pain. 1999 Dec;83(3):389-400
10568846
Naunyn Schmiedebergs Arch Pharmacol. 2004 Apr;369(4):382-90
15007538
Neurology. 2007 Nov 27;69(22):2045-53
17872363
J Neurosci. 2005 May 18;25(20):5051-60
15901787
Curr Top Med Chem. 2006;6(10):999-1023
16787276
J Biol Chem. 2000 Jul 21;275(29):22395-400
10787416
Pharmacol Ther. 2001 Apr;90(1):1-19
11448722
Eur J Neurosci. 2005 Dec;22(12):3091-8
16367775
Nat Rev Neurosci. 2000 Oct;1(1):21-30
11252765
J Physiol. 1981 Sep;318:297-316
6275068
Brain Res. 1986 Feb 19;365(2):369-76
2418923
Curr Opin Neurobiol. 2005 Jun;15(3):370-8
15922587
J Med Chem. 2007 May 31;50(11):2576-82
17489574
Br J Pharmacol. 2000 Feb;129(3):413-5
10711337
Mol Pharmacol. 2000 Sep;58(3):591-600
10953053
J Neurophysiol. 1999 Oct;82(4):1776-85
10515967
J Physiol. 2006 Aug 15;575(Pt 1):175-89
16777937
Eur J Neurosci. 2003 May;17(9):1907-20
12752790
J Neurosci. 2006 Mar 8;26(10):2599-613
16525039
Science. 1988 Jan 15;239(4837):278-80
2892268
Curr Pharm Des. 2005;11(23):2961-76
16178756
Nature. 1980 Feb 14;283(5748):673-6
6965523
Neuron. 2006 Oct 5;52(1):77-92
17015228
Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):13373-8
11698689
J Physiol. 1994 Jun 15;477 ( Pt 3):415-22
7932231
J Neurosci. 2000 Jan 1;20(1):51-8
10627580
J Neurosci. 2006 Sep 6;26(36):9340-8
16957090
Neuron. 2006 Apr 6;50(1):89-100
16600858
Eur J Neurosci. 1997 Mar;9(3):605-16
9104602
Muscle Nerve. 2005 Oct;32(4):459-72
15973653
J Physiol. 2008 Feb 1;586(3):795-802
18048450
Exp Neurol. 2000 Jun;163(2):490-4
10833324
Mol Pharmacol. 2009 Feb;75(2):272-80
19015229
Neuroscience. 1994 Feb;58(3):447-59
7513385
J Comp Neurol. 2007 Dec 1;505(4):363-78
17912742
J Neurosci. 2001 Feb 15;21(4):1096-103
11160379
J Neurosci. 2005 Mar 9;25(10):2576-85
15758167
Neuropharmacology. 2008 Jun;54(8):1271-8
18474382
J Neurosci. 1982 Aug;2(8):1119-28
6180151
Neuropharmacology. 2006 Sep;51(4):756-63
16844148
J Neurosci. 2004 Feb 4;24(5):1236-44
14762142
Brain. 2002 Jun;125(Pt 6):1177-95
12023309
Psychopharmacology (Berl). 2006 Apr;185(2):208-17
16479373
J Pharmacol Exp Ther. 1998 Aug;286(2):709-17
9694925
Proc Natl Acad Sci U S A. 2001 Oct 9;98(21):12272-7
11572947
J Neurophysiol. 2006 Aug;96(2):535-43
16394077
Prog Neurobiol. 2000 Jun;61(2):169-203
10704997
J Neurophysiol. 1983 Mar;49(3):792-803
6834099
Eur J Pharmacol. 2003 Jan 24;460(2-3):109-16
12559370
Nature. 1996 May 16;381(6579):242-5
8622767
Brain. 2005 Sep;128(Pt 9):2154-63
15947060
J Neurosci. 1993 May;13(5):1976-92
7683047
Mol Pharmacol. 2005 Apr;67(4):1053-66
15598972
Neuropharmacology. 2001 Jun;40(7):888-98
11378159
Pain. 2000 Aug;87(2):149-158
10924808
Mol Pharmacol. 2000 Jun;57(6):1218-23
10825393
Neurosci Lett. 1983 Jan 31;35(1):85-91
6843894
Nature. 1990 Aug 2;346(6283):464-7
1974033
J Physiol. 2000 Feb 1;522 Pt 3:349-55
10713961
J Neurosci. 2007 Apr 18;27(16):4492-6
17442834
Br J Pharmacol. 1989 Oct;98(2):557-73
2819334
Br J Pharmacol. 1995 Aug;115(7):1163-8
7582539
Mol Pharmacol. 2000 Aug;58(2):253-62
10908292
Trends Pharmacol Sci. 2008 Feb;29(2):99-107
18206251
J Neurochem. 2009 Apr;109(1):168-81
19187447
Neurosci Lett. 2000 Mar 17;282(1-2):73-6
10713399
Br J Pharmacol. 2009 Apr;156(8):1185-95
19298256
J Pain. 2006 Jan;7(1 Suppl 1):S3-S12
16426998
Trends Neurosci. 1997 Mar;20(3):125-31
9061867
J Physiol. 1982 Nov;332:223-62
6760380
J Neurosci. 2006 Jan 25;26(4):1281-92
16436616
Pain. 2008 Sep 15;138(3):537-545
18331780
J Neurosci. 1994 Feb;14(2):809-20
7905518
Neuron. 2002 Apr 11;34(2):209-20
11970863
J Neurosci. 2008 Apr 2;28(14):3567-76
18385315
Brain. 2003 Mar;126(Pt 3):567-78
12566278
J Neurosci. 2006 Nov 22;26(47):12325-38
17122058
J Pharmacol Exp Ther. 1998 May;285(2):724-30
9580619
J Physiol. 2006 May 15;573(Pt 1):17-34
16527853
Eur J Pharmacol. 2003 Mar 19;464(2-3):95-100
12620500
J Neurosci. 2007 Aug 15;27(33):8914-26
17699673
Eur J Pharmacol. 2001 Oct 19;429(1-3):23-37
11698024
J Physiol. 2007 Aug 1;582(Pt 3):917-25
17395626
J Neurophysiol. 1999 Oct;82(4):1768-75
10515966
Trends Neurosci. 2003 Dec;26(12):696-705
14624855
Q J Exp Physiol. 1989 Nov;74(6):757-84
2687926
Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):7151-6
9618554
Epilepsy Res. 1995 Nov;22(3):167-73
8991783
J Physiol. 2003 Dec 15;553(Pt 3):789-802
14555721
J Neurosci. 2003 Aug 6;23(18):7227-36
12904483
Epilepsy Res. 2009 Jan;83(1):1-43
19008076
J Physiol. 2005 Jul 15;566(Pt 2):519-32
15878947
Science. 1998 Dec 4;282(5395):1890-3
9836639
Neurosci Lett. 1983 Sep 30;40(2):181-6
6314210
Eur J Pharmacol. 2004 Mar 8;487(1-3):93-103
15033380
J Neurosci. 2004 May 12;24(19):4614-24
15140933
Expert Opin Investig Drugs. 2006 Oct;15(10):1167-77
16989594
Neuropharmacology. 1997 Nov-Dec;36(11-12):1747-53
9517447
J Neurosci. 2004 Jan 21;24(3):592-7
14736843
Neurosci Lett. 2000 Jan 7;278(1-2):61-4
10643801
Science. 1998 Jan 16;279(5349):403-6
9430594
Prog Biophys Mol Biol. 2000;73(2-4):135-66
10958929
Neuropharmacology. 2004 Mar;46(4):598-606
14975684
Neuroscience. 2003;120(2):353-64
12890507
Proc Natl Acad Sci U S A. 1988 Feb;85(3):948-52
2448787
Biophys J. 2003 Apr;84(4):2181-91
12668427
J Pharmacol Exp Ther. 2005 Jul;314(1):282-92
15814569
Eur J Neurosci. 2004 May;19(10):2693-702
15147303
Eur J Pharmacol. 1999 Dec 15;386(2-3):165-71
10618466
J Biol Chem. 2000 Aug 4;275(31):24089-95
10816588
J Neurochem. 2007 Jul;102(1):179-93
17437547
Nat Neurosci. 2005 Jan;8(1):51-60
15608631
Cell. 1999 Feb 5;96(3):437-46
10025409
Brain Res. 2003 Sep 12;984(1-2):84-92
12932842
Nature. 1990 Oct 25;347(6295):765-7
2172830
Mol Pharmacol. 2002 Apr;61(4):921-7
11901232
J Physiol. 2008 Apr 1;586(7):1791-801
18238816
J Physiol. 2002 May 1;540(Pt 3):875-81
11986376
Adv Exp Med Biol. 1995;363:47-56
7618529
Proc Natl Acad Sci U S A. 1989 Oct;86(20):8098-102
2573061
J Biol Chem. 1998 Jul 31;273(31):19419-23
9677360
Pain. 1988 Apr;33(1):87-107
2837713
Nature. 1998 Dec 17;396(6712):687-90
9872318
J Biol Chem. 2002 Aug 9;277(32):28545-53
12032157
Exp Brain Res. 1999 Feb;124(4):395-421
10090653
PLoS One. 2007 Dec 26;2(12):e1332
18159230
Nat Neurosci. 2003 Jun;6(6):564-71
12754513
Arzneimittelforschung. 2000 Dec;50(12):1063-70
11190770
J Neurosci. 2006 Feb 15;26(7):2053-9
16481438
J Gen Physiol. 2008 Jun;131(6):575-87
18474635
FASEB J. 2008 Apr;22(4):1135-43
17993630
J Neurosci. 2008 Oct 29;28(44):11240-9
18971466
Eur J Pharmacol. 2004 Oct 1;500(1-3):203-19
15464034
Proc Natl Acad Sci U S A. 2005 Dec 6;102(49):17828-33
16319223
Pharmacol Rev. 2003 Dec;55(4):583-6
14657415
J Comp Neurol. 2008 Oct 1;510(4):367-77
18668683
Neuron. 1995 Feb;14(2):399-405
7857647
J Neurosci. 2005 Aug 10;25(32):7449-58
16093396