Antimicrobial evaluation of imines and thiazolidinones derived from 3-phenylpropane hydrazide.
Methyl 3-phenylpropanoate (1), after hydrazination into 3-phenylpropanehydrazide (2), was converted into N-arylidene-3-phenylpropane hydrazides (3a-e), which on cyclization with thioglycolic acid yielded N-(4-oxo-2-arylthiazolidin-3-yl)-3-phenylpropanamides (4a-e). All the proposed structures of newly synthesized compounds were in full agreement with the spectral data. Due to para substitution, compound 3a, 4a and 4b were found to be the most potent when evaluated for antibacterial and antifungal activities.
Fuloria
Neeraj K
NK
Department of Pharmacy, Rameesh Institute of Vocational and Technical Education, 3-Knowledge park-1, Kasna road, Greater NOIDA, India. nfuloria@rediffmail.com
Singh
Vijender
V
Yarb
Mohammad Shahar
MS
Ali
Mohammad
M
D000890:Anti-Infective Agents / Q000494:pharmacology*; D007097:Imines / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D053778:Thiazolidines / Q000494:pharmacology*
D000890:Anti-Infective Agents; D007097:Imines; D053778:Thiazolidines