The Impact of HIV and Malaria Coinfection: What Is Known and Suggested Venues for Further Study.
HIV and malaria have similar global distributions. Annually, 500 million are infected and 1 million die because of malaria. 33 million have HIV and 2 million die from it each year. Minor effects of one infection on the disease course or outcome for the other would significantly impact public health because of the sheer number of people at risk for coinfection. While early population-based studies showed no difference in outcomes between HIV-positive and HIV-negative individuals with malaria, more recent work suggests that those with HIV have more frequent episodes of symptomatic malaria and that malaria increases HIV plasma viral load and decreases CD4+ T cells. HIV and malaria each interact with the host's immune system, resulting in a complex activation of immune cells, and subsequent dysregulated production of cytokines and antibodies. Further investigation of these interactions is needed to better define effects of coinfection.
Hochman
Sarah
S
Department of Medicine, Division of Infectious Diseases, Montefiore Medical Center, Albert Einstein College of Medicine, Ullmann 1205, 1300 Morris Park Avenue, Bronx, NY 10461, USA.
Kim
Kami
K
Parasitol Today. 2000 Nov;16(11):469-76
11063857
J Investig Med. 2003 May;51(3):128-40
12769195
J Neurosci. 2006 Jan 25;26(4):1098-106
16436595
Lancet. 2005 Jan 15-21;365(9455):233-40
15652606
J Acquir Immune Defic Syndr. 2004 Mar 1;35(3):223-32
15076236
Pediatr Infect Dis J. 1997 Sep;16(9):876-81
9306483
J Infect Dis. 2006 Jul 15;194(2):198-207
16779726
Antimicrob Agents Chemother. 2005 Jul;49(7):2983-5
15980379
Infect Immun. 2004 Oct;72(10):5630-7
15385460
Exp Parasitol. 1995 Feb;80(1):54-63
7821411
Infect Immun. 2000 Jul;68(7):4135-44
10858230
Parasitol Int. 2006 Jun;55(2):107-12
16388977
AIDS. 2003 Mar 7;17(4):595-603
12598780
AIDS. 1999 Mar 11;13(4):487-94
10197377
J Immunol. 2005 May 15;174(10):5921-5
15879082
Int J Parasitol. 1996 Jun;26(6):647-55
8875310
Clin Infect Dis. 2005 Dec 1;41(11):1631-7
16267737
Am J Trop Med Hyg. 1999 May;60(5):733-7
10344643
J Thromb Haemost. 2007 Jan;5(1):155-65
17002660
J Acquir Immune Defic Syndr. 2006 Nov 1;43(3):363-7
17079994
Blood. 2007 Nov 1;110(9):3426-35
17693580
Am J Trop Med Hyg. 2009 Jan;80(1):119-25
19141849
Trends Immunol. 2003 Sep;24(9):491-9
12967673
J Acquir Immune Defic Syndr. 2005 Mar 1;38(3):310-3
15735450
J Immunol. 2006 Jan 1;176(1):441-50
16365437
Lancet. 2006 Apr 15;367(9518):1256-61
16631881
Antimicrob Agents Chemother. 2007 Feb;51(2):759-62
17088482
Virology. 2009 Mar 1;385(1):126-33
19135225
PLoS Med. 2007 May;4(5):e181
17535103
AIDS. 2004 Feb 20;18(3):547-54
15090809
Am J Trop Med Hyg. 2000 Jan;62(1):38-44
10761722
AIDS. 2008 Mar 30;22(6):785-7
18356610
Antimicrob Agents Chemother. 2006 Feb;50(2):639-48
16436721
Immunol Today. 1993 Mar;14(3):107-11
8096699
Microcirculation. 2008 Feb;15(2):81-107
18260002
Emerg Infect Dis. 2005 Sep;11(9):1410-9
16229771
Clin Vaccine Immunol. 2008 Apr;15(4):617-21
18199738
J Dev Behav Pediatr. 2002 Oct;23(5):353-64
12394524
J Infect Dis. 2006 Jan 1;193(1):9-15
16323126
J Infect Dis. 2009 Jan 1;199(1):134-41
19032102
Am J Trop Med Hyg. 2003 Oct;69(4):447-9
14640507
Int J Parasitol. 2006 May 1;36(5):555-68
16616145
J Pathol. 2008 Jan;214(2):231-41
18161758
Am J Trop Med Hyg. 2001 Mar-Apr;64(3-4):207-13
11442219
J Immunol. 1993 Nov 1;151(9):4811-20
8409439
Emerg Infect Dis. 2004 Apr;10(4):643-52
15200854
Pediatr Infect Dis J. 2003 Dec;22(12):1057-63
14688565
Int J Epidemiol. 1998 Apr;27(2):296-301
9602413
Lancet. 2003 Sep 27;362(9389):1039-41
14522535
AIDS. 2006 Jan 9;20(2):275-80
16511422
Infect Immun. 2009 May;77(5):1917-23
19223480
Nature. 1999 Jul 1;400(6739):73-7
10403251
J Virol. 2008 Aug;82(15):7591-600
18508884
Eur J Immunol. 1997 Jul;27(7):1719-25
9247583
J Leukoc Biol. 2000 Sep;68(3):383-90
10985255
J Infect Dis. 2004 Dec 1;190(11):1998-2000
15529265
Lancet. 2000 Sep 23;356(9235):1051-6
11009139
Br J Haematol. 1980 Oct;46(2):171-83
7000157
J Neuroimmune Pharmacol. 2006 Jun;1(2):160-81
18040782
Clin Lab Haematol. 1988;10(1):33-40
3284694
J Acquir Immune Defic Syndr. 2006 Jan 1;41(1):129-30
16340488