Two 22S-solanidine-type steroidal alkaloids from Fritillaria anhuiensis.
Phytochemical investigation of the fresh bulbs of Fritillaria anhuiensis S. C. Chen et S. E. Yin, resulted in the isolation of a known steroidal alkaloid solanidine of (22S,25S)-solanid-5-en-3beta-ol (1), which has never yet been found as a natural substance, and of a new steroidal alkaloid (22S,25S)-solanid-5,20(21)-dien-3beta-ol. Compounds 1 and 2 were the first solanidine-type alkaloids with 22-S configuration discovered from nature. Their structures were elucidated based on spectroscopic analysis, including 1D and 2D NMR experiments.
Shou
Qing Yao
QY
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, People's Republic of China.
Tan
Qing
Q
Wu Shen
Zheng
Z
D004144:Diosgenin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification; D031410:Fritillaria / Q000737:chemistry*; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry*; D018517:Plant Roots
C550888:(22S,25S)-solanid-5,20(21)-dien-3beta-ol; C550889:(22S,25S)-solanid-5-en-3beta-ol; D010936:Plant Extracts; D004144:Diosgenin; C013255:solanidine