The use of intravenous aminobisphosphonates for the treatment of Paget's disease of bone.
Paget's disease of bone is a focal skeletal disorder characterized by the formation of structurally abnormal bone, deformity and other complications leading to significant disability and bone pain. Recently, the availability of newer, more potent nitrogen-containing bisphosphonates has improved treatment outcomes, allowing a more effective and convenient management of this disorder.
Gennari
Luigi
L
Department of Internal Medicine, Endocrine-Metabolic Sciences and Biochemistry, University of Siena, 53100 Siena, Italy. gennari@unisi.it
Merlotti
Daniela
D
Mossetti
Giuseppe
G
Rendina
Domenico
D
De Paola
Vincenzo
V
Martini
Giuseppe
G
Nuti
Ranuccio
R
D000818:Animals; D050071:Bone Density Conservation Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000627:therapeutic use*; D004164:Diphosphonates / Q000008:administration & dosage* / Q000737:chemistry / Q000627:therapeutic use*; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use; D007275:Injections, Intravenous; D010001:Osteitis Deformans / Q000188:drug therapy*; D000077268:Pamidronate; D000077211:Zoledronic Acid
D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D007093:Imidazoles; D000077211:Zoledronic Acid; C053389:6-amino-1-hydroxyhexane-1,1-diphosphonate; D000077268:Pamidronate