title: Management of cow's milk protein allergy in infants and young children: an expert panel perspective.
abstract: Cow's milk protein allergy is a condition commonly managed by general practitioners and paediatricians. The diagnosis is usually made in the first 12 months of life. Management of immediate allergic reactions and anaphylaxis includes the prevention of accidental food ingestion and provision of an adrenaline autoinjector, if appropriate. By contrast, the clinical course of delayed food-allergic manifestations is characterised by chronicity, and is often associated with nutritional or behavioural sequelae. Correct diagnosis of these non-IgE-mediated conditions may be delayed due to a lack of reliable diagnostic markers. This review aims to guide clinicians in the: (i) diagnostic evaluation (skin prick testing or measurement of food-specific serum IgE levels; indications for diagnostic challenges for suspected IgE- and non-IgE-mediated food allergy), (ii) dietary treatment, (iii) assessment of response to treatment, (iv) differential diagnosis and further diagnostic work-up in non-responders, (v) follow-up assessment of tolerance development and (vi) recommendations for further referral.
authors.affiliation: Murdoch Childrens Research Institute, Melbourne, VIC, Australia.
authors.forename: Katrina J
authors.initials: KJ
authors.lastname: Allen
authors.forename: Geoffrey P
authors.initials: GP
authors.lastname: Davidson
authors.forename: Andrew S
authors.initials: AS
authors.lastname: Day
authors.forename: David J
authors.initials: DJ
authors.lastname: Hill
authors.forename: Andrew S
authors.initials: AS
authors.lastname: Kemp
authors.forename: Jane E
authors.initials: JE
authors.lastname: Peake
authors.forename: Susan L
authors.initials: SL
authors.lastname: Prescott
authors.forename: Albert
authors.initials: A
authors.lastname: Shugg
authors.forename: John K H
authors.initials: JK
authors.lastname: Sinn
authors.forename: Ralf G
authors.initials: RG
authors.lastname: Heine
mesh_terms: D000707:Anaphylaxis; D000818:Animals; D001315:Australia; D002417:Cattle; D002675:Child, Preschool; D002985:Clinical Protocols; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000139:chemically induced; D007223:Infant; D007231:Infant, Newborn; D016269:Milk Hypersensitivity / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D008894:Milk Proteins / Q000009:adverse effects*
chemical_list: D008894:Milk Proteins