The neurobiological properties of tianeptine (Stablon): from monoamine hypothesis to glutamatergic modulation.
Tianeptine is a clinically used antidepressant that has drawn much attention, because this compound challenges traditional monoaminergic hypotheses of depression. It is now acknowledged that the antidepressant actions of tianeptine, together with its remarkable clinical tolerance, can be attributed to its particular neurobiological properties. The involvement of glutamate in the mechanism of action of the antidepressant tianeptine is consistent with a well-developed preclinical literature demonstrating the key function of glutamate in the mechanism of altered neuroplasticity that underlies the symptoms of depression. This article reviews the latest evidence on tianeptine's mechanism of action with a focus on the glutamatergic system, which could provide a key pathway for its antidepressant action. Converging lines of evidences demonstrate actions of tianeptine on the glutamatergic system, and therefore offer new insights into how tianeptine may be useful in the treatment of depressive disorders.
McEwen
B S
BS
Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY, USA. mcewen@mail.rockefeller.edu
Chattarji
S
S
Diamond
D M
DM
Jay
T M
TM
Reagan
L P
LP
Svenningsson
P
P
Fuchs
E
E
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology* / Q000627:therapeutic use; D001007:Anxiety / Q000188:drug therapy / Q000378:metabolism; D015306:Biogenic Monoamines / Q000378:metabolism*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D003072:Cognition Disorders / Q000188:drug therapy; D003863:Depression / Q000188:drug therapy / Q000378:metabolism; D004195:Disease Models, Animal; D018698:Glutamic Acid / Q000378:metabolism*; D006801:Humans; D009473:Neuronal Plasticity / Q000187:drug effects; D013315:Stress, Psychological / Q000378:metabolism; D013841:Thiazepines / Q000494:pharmacology* / Q000627:therapeutic use
D014151:Anti-Anxiety Agents; D000929:Antidepressive Agents, Tricyclic; D015306:Biogenic Monoamines; D013841:Thiazepines; C050504:tianeptine; D018698:Glutamic Acid
Behav Neurosci. 1999 Oct;113(5):902-13
10571474
Cell Mol Neurobiol. 2003 Jun;23(3):419-30
12825836
Pol J Pharmacol. 2002 Nov-Dec;54(6):707-10
12866729
Behav Pharmacol. 1991 Feb;2(1):37-46
11224046
Science. 1998 Jan 9;279(5348):222-6
9422694
Neuropharmacology. 1999 Dec;38(12):1831-9
10608278
Hum Psychopharmacol. 2003 Jun;18(4):277-80
12766932
Biol Psychiatry. 2006 Oct 15;60(8):867-73
16934773
Eur J Neurosci. 2007 Dec;26(12):3509-17
18088278
Ann N Y Acad Sci. 2003 Nov;1003:273-91
14684452
Clin Neuropharmacol. 1988;11 Suppl 2:S97-102
3052827
Psychopharmacology (Berl). 2001 Feb;154(1):50-60
11292006
Neuropharmacology. 2003 May;44(6):801-9
12681378
Neurophysiol Clin. 1988 Aug;18(4):369-81
3185462
Biol Psychiatry. 1991 Sep 15;30(6):609-17
1932408
Ann N Y Acad Sci. 2003 Nov;1003:250-72
14684451
J Neurosci. 2005 Mar 30;25(13):3270-9
15800181
Am J Pathol. 2001 Feb;158(2):453-68
11159183
Psychopharmacology (Berl). 1991;104(1):81-5
1831909
Brain Res Brain Res Rev. 2001 Dec;38(1-2):247-89
11750934
Neuropharmacology. 2001 Sep;41(3):360-8
11522327
Biol Psychiatry. 2008 Feb 15;63(4):349-52
17643398
Brain Res. 2005 Apr 25;1042(1):92-8
15823257
Psychoneuroendocrinology. 2003 Jan;28(1):19-34
12445834
J Mol Neurosci. 1998 Jun;10(3):219-33
9770644
Neuropharmacology. 2001 Jun;40(8):1028-33
11406194
J Neurosci. 2002 May 1;22(9):3638-44
11978839
Psychopharmacol Bull. 2001 Spring;35(2):5-49
12397885
Neuropsychopharmacology. 2006 Nov;31(11):2405-14
16482087
Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):2179-84
14766991
Clin Neuropharmacol. 1988;11 Suppl 2:S43-50
3052825
Alcohol Alcohol. 1993 May;28(3):281-6
8352839
Neuropsychobiology. 1994;30(2-3):85-93
7800169
J Comp Neurol. 1985 Oct 1;240(1):37-59
4056104
Psychoneuroendocrinology. 2004 Jul;29(6):778-90
15110927
CNS Drugs. 2008;22(1):15-26
18072812
Encephale. 2003 Jul-Aug;29(4 Pt 1):322-8
14615702
Biol Psychiatry. 2004 Apr 15;55(8):789-96
15050859
Eur J Neurosci. 2003 Jun;17(11):2409-17
12814372
Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):14002-8
9391142
Eur Psychiatry. 2002 Jul;17 Suppl 3:331-40
15177089
Pharmacol Res. 2001 May;43(5):411-23
11394932
Biol Psychiatry. 2006 Jun 15;59(12):1116-27
16631126
Behav Neurosci. 1996 Dec;110(6):1321-34
8986335
Eur J Pharmacol. 1995 Dec 27;294(1):125-35
8788424
CNS Drugs. 2002;16(1):65-75
11772119
J Affect Disord. 1999 Dec;56(2-3):109-18
10701468
FASEB J. 2008 Sep;22(9):3129-34
18492725
Encephale. 2002 Jul-Aug;28(4):343-9
12232543
J Neurochem. 1993 Nov;61(5):1957-60
7901339
Hum Psychopharmacol. 2001 Apr;16(3):219-227
12404574
Brain Res. 1993 Jun 25;615(1):87-94
8364729
Neuroscience. 1995 Nov;69(1):89-98
8637636
Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1387-92
12552118
Biol Psychiatry. 2003 Aug 1;54(3):338-52
12893109
Biol Psychiatry. 2004 Jun 15;55(12):1171-8
15184036
Eur J Pharmacol. 2007 Jun 22;565(1-3):68-75
17368617
Eur Neuropsychopharmacol. 2004 May;14(3):175-83
15056476
Neuropsychobiology. 1997;35(1):24-9
9018020
CNS Drugs. 2001;15(3):231-59
11463130
Eur Neuropsychopharmacol. 2004 Dec;14 Suppl 5:S481-90
15550346
Eur Psychiatry. 2002 Jul;17 Suppl 3:318-30
15177088
Eur J Neurosci. 2001 Jul;14(1):161-6
11488960
Presse Med. 1996 Mar 16;25(9):461-8
8685201
Behav Neurosci. 2008 Apr;122(2):282-92
18410168
Neuropharmacology. 2001 Aug;41(2):272-81
11489464
Curr Opin Pharmacol. 2004 Feb;4(1):4-11
15018832
Neuropharmacology. 1992 Mar;31(3):221-7
1630590
Neuropharmacology. 2004 Feb;46(2):151-9
14680755
Br J Psychiatry Suppl. 1992 Feb;(15):44-50
1356357
Int J Neuropsychopharmacol. 2009 May;12(4):553-9
18976544
Curr Drug Targets CNS Neurol Disord. 2004 Jun;3(3):181-94
15180479
Brain Res Brain Res Rev. 1999 Jan;29(1):83-120
9974152
Neuroscience. 1997 Mar;77(1):65-73
9044375
Drugs. 1995 Mar;49(3):411-39
7774514
Acta Psychiatr Scand. 1998 May;97(5):351-7
9611085
Eur Neuropsychopharmacol. 2008 Feb;18(2):87-98
17566714
J Clin Psychopharmacol. 2003 Apr;23(2):155-68
12640217
Neuropsychobiology. 1989;22(1):41-8
2700774
Curr Drug Targets CNS Neurol Disord. 2002 Jun;1(3):297-317
12769621
Pharmacol Ther. 2007 Jul;115(1):116-47
17582504
Neuropsychopharmacology. 2008 Jan;33(1):88-109
17851537
Neuropharmacology. 1990 Jan;29(1):1-8
1689469
Stress. 2006 Mar;9(1):29-40
16753931
Eur Neuropsychopharmacol. 2004 Dec;14 Suppl 5:S497-502
15550348
Brain Res. 1994 Mar 7;639(1):167-70
8180832
Eur J Pharmacol. 2000 Sep 1;403(1-2):55-65
10969144
Eur J Pharmacol. 2005 May 2;514(1):25-34
15878321
Eur J Neurosci. 2007 May;25(10):3109-14
17561824
CNS Neurol Disord Drug Targets. 2007 Apr;6(2):87-100
17430147
Eur Neuropsychopharmacol. 2002 Oct;12(5):417-25
12208559
Biol Psychiatry. 2006 Feb 1;59(3):244-51
16140276
J Neurosci. 1995 Jun;15(6):4687-92
7790933
Neuropharmacology. 1994 Aug;33(8):1011-6
7531300
Eur Psychiatry. 2002 Jul;17 Suppl 3:311-7
15177087
Biol Psychiatry. 1999 Nov 1;46(9):1181-91
10560024
Hum Psychopharmacol. 2002 Aug;17(6):299-303
12404675
Psychopharmacology (Berl). 1990;102(2):227-33
2274605
Sci STKE. 2003 Nov 04;2003(207):pe49
14600293
Ann N Y Acad Sci. 2003 Nov;1003:292-308
14684453
Neuropharmacology. 2009 Jan;56(1):37-46
18657555
Eur J Neurosci. 2002 Sep;16(5):807-16
12372016
J Neurochem. 1995 Jul;65(1):268-74
7790870
Semin Clin Neuropsychiatry. 2002 Oct;7(4):281-92
12382210
Mol Psychiatry. 2005 Jun;10(6):525-37
15753957
Br J Psychiatry Suppl. 1992 Feb;(15):51-5
1356358
Eur J Pharmacol. 1999 Apr 29;371(2-3):113-22
10357248
Naunyn Schmiedebergs Arch Pharmacol. 1995 Feb;351(2):119-25
7770094
Eur Neuropsychopharmacol. 2004 Dec;14 Suppl 5:S491-5
15550347
Neurosci Lett. 2005 Apr 22;378(3):131-4
15781145
J Neurosci. 2002 Aug 1;22(15):6810-8
12151561
Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12796-801
11675510
Cereb Cortex. 2004 Feb;14(2):224-9
14704220
Clin Neuropharmacol. 1988;11 Suppl 2:S32-42
3180116
J Neurochem. 2005 Jun;93(5):1345-52
15934953
Br J Psychiatry Suppl. 1992 Feb;(15):56-60
1389023
Eur J Pharmacol. 1992 Nov 3;222(1):157-62
1468492
Curr Med Res Opin. 2003;19(2):114-24
12740155
Psychopharmacology (Berl). 2001 Apr;154(4):356-61
11349388
Naunyn Schmiedebergs Arch Pharmacol. 1987 Nov;336(5):478-82
3437921