Metalloproteins and metal sensing.
Almost half of all enzymes must associate with a particular metal to function. An ambition is to understand why each metal-protein partnership arose and how it is maintained. Metal availability provides part of the explanation, and has changed over geological time and varies between habitats but is held within vital limits in cells. Such homeostasis needs metal sensors, and there is an ongoing search to discover the metal-sensing mechanisms. For metalloproteins to acquire the right metals, metal sensors must correctly distinguish between the inorganic elements.
Waldron
Kevin J
KJ
Cell & Molecular Biosciences, Medical School, Newcastle University, Newcastle NE2 4HH, UK.
Rutherford
Julian C
JC
Ford
Dianne
D
Robinson
Nigel J
NJ
D000494:Allosteric Regulation; D000818:Animals; D001419:Bacteria / Q000378:metabolism; D055162:Biocatalysis; D015870:Gene Expression; D008667:Metalloproteins / Q000378:metabolism*; D008670:Metals / Q000378:metabolism*; D020871:RNA Stability; D015003:Yeasts / Q000378:metabolism
D008667:Metalloproteins; D008670:Metals
Nucleic Acids Res. 2005 Oct 12;33(18):5715-27
16221973
Nature. 2008 Oct 23;455(7216):1138-42
18948958
Mol Cell Biol. 2009 Jan;29(1):129-39
18936158
Science. 1999 Apr 30;284(5415):805-8
10221913
EMBO J. 1996 Jul 1;15(13):3377-84
8670839
Cell. 2005 Jan 14;120(1):99-110
15652485
J Biol Chem. 2001 Nov 9;276(45):42322-32
11524427
J Biol Chem. 2003 Nov 14;278(46):45391-6
12960168
J Inorg Biochem. 1998 Sep;71(3-4):115-27
9833317
EMBO J. 2000 Jun 15;19(12):2845-55
10856230
J Biol Chem. 2001 Aug 3;276(31):29515-9
11390404
J Biol Chem. 2008 Apr 18;283(16):10276-86
18281282
J Biol Chem. 2002 Oct 11;277(41):38441-8
12163508
Nat Rev Microbiol. 2009 Jan;7(1):25-35
19079350
Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4237-42
19240214
New Phytol. 2009 Jun;182(4):799-816
19402880
J Biol Chem. 1999 Dec 17;274(51):36252-60
10593913
J Biol Chem. 2004 Apr 23;279(17):17428-33
14976198
Mol Cell Biol. 2003 Dec;23(23):8471-85
14612393
J Mol Biol. 2006 Apr 7;357(4):1167-83
16483601
Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14322-7
11734641
Nature. 2005 May 5;435(7038):42
15875011
J Biol Chem. 2007 Mar 9;282(10):6992-7000
17202136
Nature. 2005 Sep 29;437(7059):681-6
16193043
J Biol Chem. 2006 Jun 30;281(26):17661-9
16648636
EMBO J. 2003 Oct 1;22(19):5137-46
14517251
J Biol Chem. 2007 Oct 19;282(42):30442-51
17642475
Environ Microbiol. 2007 Feb;9(2):403-13
17222138
Biochemistry. 2006 Dec 26;45(51):15359-72
17176058
J Biol Chem. 2002 Jul 5;277(27):23981-4
12011036
EMBO J. 1993 Dec 15;12(13):5051-6
8262047
Biochemistry. 2007 Dec 25;46(51):15018-26
18044966
J Biol Chem. 2007 Apr 6;282(14):10423-31
17234632
Mol Microbiol. 2003 Apr;48(2):495-506
12675807
J Biol Chem. 2002 Jun 21;277(25):22950-8
11956219
Nat Chem Biol. 2008 Mar;4(3):176-85
18277979
Nat Rev Mol Cell Biol. 2004 May;5(5):343-54
15122348
Nature. 2007 Jan 4;445(7123):91-4
17203061
Nature. 2009 Apr 9;458(7239):750-3
19360085
Biochemistry. 2002 May 21;41(20):6469-76
12009910
J Inorg Biochem. 2008 Feb;102(2):342-6
17986390
Curr Opin Chem Biol. 2008 Apr;12(2):222-8
18342639
Biochemistry. 2008 Feb 19;47(7):1938-46
18193897
Mol Cell Biol. 1998 May;18(5):2514-23
9599102
Science. 2003 Sep 5;301(5638):1383-7
12958362
J Biol Chem. 2001 Mar 23;276(12):8793-7
11134042
J Biol Chem. 2000 Mar 31;275(13):9377-84
10734081
Nucleic Acids Res. 2008 May;36(9):3128-38
18411209
Biochim Biophys Acta. 2006 Jul;1763(7):747-58
16828895
Nature. 2008 Mar 6;452(7183):56-61
18322527
Am J Physiol Gastrointest Liver Physiol. 2009 Feb;296(2):G433-44
19033537
Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11749-54
11573009
J Biol Inorg Chem. 2008 Nov;13(8):1205-18
18604568
Nature. 2006 May 18;441(7091):341-4
16572122
Nature. 2005 Mar 10;434(7030):177-82
15674245
Nature. 1999 Feb 25;397(6721):694-7
10067892
Mol Biol Cell. 2007 Aug;18(8):2980-90
17538022
EMBO J. 2004 Jul 21;23(14):2872-81
15215895
Blood. 2008 Jul 15;112(2):219-30
18606887
Science. 2001 Jun 29;292(5526):2488-92
11397910
Genes Dev. 2005 Apr 15;19(8):891-6
15833915
J Biol Chem. 2004 Feb 6;279(6):4523-30
14612438
Mol Genet Genomics. 2001 Jul;265(5):873-82
11523804
Cell Metab. 2008 Jun;7(6):555-64
18522836
Nat Chem Biol. 2009 May;5(5):333-40
19377460
Nature. 2009 Apr 9;458(7239):714-5
19360074
Clin Biochem. 2004 Mar;37(3):165-74
14972637
Nat Chem Biol. 2007 Mar;3(3):144-53
17301803
EMBO J. 1996 Nov 15;15(22):6084-95
8947031
Science. 2006 Dec 22;314(5807):1903-8
17185597
J Biol Chem. 2005 Mar 18;280(11):10135-40
15649888
J Biol Chem. 2000 Jul 14;275(28):21048-54
10777486
Proc Natl Acad Sci U S A. 2006 Jun 6;103(23):8674-9
16720702
Chem Commun (Camb). 2002 Mar 21;(6):588-9
12120136
Proc Natl Acad Sci U S A. 2006 Nov 21;103(47):17822-7
17098870
Nature. 2004 Oct 7;431(7009):689-92
15470428
Science. 1997 Oct 31;278(5339):853-6
9346482
Science. 2004 Dec 17;306(5704):2090-3
15514116
Arch Biochem Biophys. 2007 Jul 15;463(2):149-67
17531189
Nature. 2001 Feb 15;409(6822):860-921
11237011
Physiol Genomics. 2008 Jul 15;34(2):205-14
18477665
Annu Rev Biophys. 2008;37:97-116
18573074
Nature. 2007 Feb 22;445(7130):881-5
17293876
Science. 1993 Aug 6;261(5122):715-25
8342038
Dalton Trans. 2007 Aug 7;(29):3107-20
17637984
Mol Cell. 2000 Feb;5(2):299-309
10882071
Eukaryot Cell. 2004 Feb;3(1):1-13
14871932
Nat Chem Biol. 2006 Aug;2(8):406-14
16850017
Nat Struct Biol. 1998 Jul;5(7):551-5
9665167
Cell. 1988 Nov 18;55(4):705-17
3052856
EMBO J. 1995 Mar 15;14(6):1231-9
7720713
J Biol Chem. 2009 Jan 2;284(1):404-413
18977757
Mol Pharmacol. 2008 Sep;74(3):705-13
18483225
Arch Biochem Biophys. 2007 Jul 15;463(2):201-10
17462582
J Biol Chem. 1995 Sep 15;270(37):21645-51
7665579
Mol Cell Biol. 2008 Jul;28(13):4275-84
18458062