title: [MR imaging of liver metastasis using Gd-EOB-DTPA].
abstract: This article describes the imaging diagnosis of metastatic liver tumor, especially using the new liver-specific contrast agent, Gd-EOB-DTPA. The extracellular contrast agent, which is used on either CT and MRI, reflects the different vascularity of tumor and surrounding normal liver parenchyma and sometimes failed to diagnose liver metastasis which is similar in vascularity to liver parenchyma. The liver-specific contrast agent Gd-EOB-DTPA has lipophilic characteristics and some of them are taken up in the liver and excreted into the bile. Since a tumor which has no liver function does not take up Gd-EOB-DTPA, differentiation of the liver and the tumor is easy with this contrast agent. Although development of new diagnostic machines and the new contrast agents will improve the sensitivity of the detection of metastatic liver tumors, the selection of the imaging examination and contrast agent is necessary to improve the efficacy of not only the diagnosis of metastatic liver tumors, but also other metastases and local recurrences.
authors.affiliation: Dept. of Radiology, School of Medicine, Tokyo Women's Medical University.
authors.forename: Ryohei
authors.initials: R
authors.lastname: Kuwatsuru
mesh_terms: D003287:Contrast Media / Q000008:administration & dosage; D019786:Gadolinium DTPA / Q000008:administration & dosage; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000556:secondary*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; C073590:gadolinium ethoxybenzyl DTPA; D019786:Gadolinium DTPA