WNT5a in tongue and fungiform Papilla development.
Fungiform papillae are complex taste organs that develop in a pattern on anterior tongue in rodent embryos. Several intrinsic secreted molecules are important for papilla development and patterning, including sonic hedgehog, bone morphogenetic proteins, Noggin, epidermal growth factor, and WNTs. Recent data about roles of WNTs in regulation of tongue and fungiform papilla development lead to new insights about the importance of tissue and timing contexts when studying the effects of morphogenetic proteins. WNT/beta-catenin signaling is required for formation of fungiform papillae, but not for determining tongue size and shape. In contrast, WNT5a apparently is important for tongue outgrowth, but not papilla development. Preliminary data from WNT5a mutant mice separate genetic programs for papilla number from those for tongue shape and size.
Liu
Hong-Xiang
HX
School of Dentistry, University of Michigan, Ann Arbor, Michigan 48109-1078, USA.
Grosse
Ann M Staubach
AM
Walton
Katherine D
KD
Saims
Daniel A
DA
Gumucio
Deborah L
DL
Mistretta
Charlotte M
CM
D000818:Animals; D051379:Mice; D008855:Microscopy, Electron, Scanning; D015398:Signal Transduction; D013650:Taste Buds / Q000254:growth & development*; D051153:Wnt Proteins / Q000378:metabolism / Q000502:physiology*; D000071818:Wnt-5a Protein; D051176:beta Catenin / Q000378:metabolism
D051153:Wnt Proteins; D000071818:Wnt-5a Protein; C102068:Wnt10b protein, mouse; C438615:Wnt5a protein, mouse; D051176:beta Catenin
J Comp Neurol. 1997 Jan 20;377(3):324-40
8989649
Arch Histol Cytol. 2006 Dec;69(4):199-208
17287575
Development. 1999 Mar;126(6):1211-23
10021340
Dev Dyn. 2008 Sep;237(9):2378-93
18729215
Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2253-8
17284610
Dev Biol. 2004 Dec 15;276(2):280-300
15581865
Ann N Y Acad Sci. 1998 Nov 30;855:1-13
9929582
Development. 2008 Apr;135(7):1365-76
18305003
Science. 2008 Apr 18;320(5874):365-9
18420933
Genes Dev. 2006 Oct 1;20(19):2654-9
17015430
Dev Biol. 2006 Sep 1;297(1):198-213
16828469
Development. 2007 Nov;134(21):3929-39
17898001
Dev Biol. 2003 Feb 1;254(1):1-18
12606278
Dev Biol. 2003 Mar 15;255(2):263-77
12648489
Nat Genet. 2007 Jan;39(1):106-12
17128274
Cell Tissue Res. 2001 Jan;303(1):35-45
11236003