Substrate specificity of N-acetylhexosamine kinase towards N-acetylgalactosamine derivatives.
We report herein a bacterial N-acetylhexosamine kinase, NahK, with broad substrate specificity towards structurally modified GalNAc analogues, and the production of a GalNAc-1-phosphate library using this kinase.
Cai
Li
L
Departments of Chemistry and Biochemistry, The Ohio State University, 484 w. 12th Ave. Columbus, OH 43210, USA.
Guan
Wanyi
W
Wang
Wenjun
W
Zhao
Wei
W
Kitaoka
Motomitsu
M
Shen
Jie
J
O'Neil
Crystal
C
Wang
Peng George
PG
D000116:Acetylgalactosamine / Q000031:analogs & derivatives* / Q000378:metabolism*; D001644:Bifidobacterium / Q000201:enzymology*; D010770:Phosphotransferases / Q000378:metabolism*; D054852:Small Molecule Libraries / Q000737:chemistry / Q000378:metabolism; D013379:Substrate Specificity
D054852:Small Molecule Libraries; D010770:Phosphotransferases; D000116:Acetylgalactosamine