title: Controlled and extended drug release behavior of chitosan-based nanoparticle carrier.
abstract: Controlled drug release is presently gaining significant attention. In this regard, we describe here the synthesis (based on the understanding of chemical structure), structural morphology, swelling behavior and drug release response of chitosan intercalated in an expandable layered aluminosilicate. In contrast to pure chitosan, for which there is a continuous increase in drug release with time, the chitosan-aluminosilicate nanocomposite carrier was characterized by controlled and extended release. Drug release from the nanocomposite particle carrier occurred by degradation of the carrier to its individual components or nanostructures with a different composition. In both the layered aluminosilicate-based mineral and chitosan-aluminosilicate nanocomposite carriers the positively charged chemotherapeutic drug strongly bound to the negatively charged aluminosilicate and release of the drug was slow. Furthermore, the pattern of drug release from the chitosan-aluminosilicate nanocomposite carrier was affected by pH and the chitosan/aluminosilicate ratio. The study points to the potential application of this hybrid nanocomposite carrier in biomedical applications, including tissue engineering and controlled drug delivery.
authors.affiliation: Biomaterials and Biomedical Engineering Research Laboratory, Center for Structural and Functional Materials, University of Louisiana at Lafayette, PO Box 44130, Lafayette, LA 70504-4130, USA.
authors.forename: Q
authors.initials: Q
authors.lastname: Yuan
authors.forename: J
authors.initials: J
authors.lastname: Shah
authors.forename: S
authors.initials: S
authors.lastname: Hein
authors.forename: R D K
authors.initials: RD
authors.lastname: Misra
mesh_terms: D000538:Aluminum Silicates / Q000737:chemistry*; D048271:Chitosan / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000737:chemistry*; D004058:Diffusion; D004317:Doxorubicin / Q000008:administration & dosage / Q000737:chemistry*; D004339:Drug Compounding / Q000379:methods; D008422:Materials Testing; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure*; D010316:Particle Size
chemical_list: D000538:Aluminum Silicates; D003692:Delayed-Action Preparations; C049037:aluminosilicate; D004317:Doxorubicin; D048271:Chitosan