title: Effects of caffeic acid and cinnamic acid on glucose uptake in insulin-resistant mouse hepatocytes.
abstract: Tumor necrosis factor-alpha was used to induce insulin resistance of mouse liver FL83B cells. Two phenolic acids, caffeic acid and cinnamic acid, were then added separately to investigate their effects on glucose uptake of the insulin-resistant cells. The results suggest that these two phenolic acids may promote insulin receptor tyrosyl phosphorylation, up-regulate the expression of insulin signal associated proteins, including insulin receptor, phosphatidylinositol-3 kinase, glycogen synthase, and glucose transporter-2, increase the uptake of glucose, and alleviate insulin resistance in cells as a consequence.
authors.affiliation: Graduate Institute of Food Science and Technology, College of Bioresources and Agriculture, National Taiwan University, Taipei 106, Taiwan.
authors.forename: Da-Wei
authors.initials: DW
authors.lastname: Huang
authors.forename: Szu-Chuan
authors.initials: SC
authors.lastname: Shen
authors.forename: James Swi-Bea
authors.initials: JS
authors.lastname: Wu
mesh_terms: D000818:Animals; D002109:Caffeic Acids / Q000494:pharmacology*; D002460:Cell Line; D002934:Cinnamates / Q000494:pharmacology*; D005947:Glucose / Q000378:metabolism*; D022781:Hepatocytes / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism*; D007333:Insulin Resistance; D051379:Mice; D019869:Phosphatidylinositol 3-Kinases / Q000032:analysis; D010766:Phosphorylation / Q000187:drug effects; D011972:Receptor, Insulin / Q000032:analysis / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology; D014443:Tyrosine / Q000378:metabolism
chemical_list: D002109:Caffeic Acids; D002934:Cinnamates; D005947:Glucose; D019869:Phosphatidylinositol 3-Kinases; D011972:Receptor, Insulin; D014409:Tumor Necrosis Factor-alpha; D014443:Tyrosine; C029010:cinnamic acid; C040048:caffeic acid