[Transforming growth factor-beta and its receptors in scleroderma].
The hallmark of scleroderma is fibrosis by excessive extracellular matrix (ECM) deposition in the skin, lung, and other organs. Increasing evidence suggests that overexpression of transforming growth factor-beta (TGF-beta) and its receptors play a key pathogenic role in the development of tissue fibrosis in scleroderma. TGF-beta is known to induce the expression of ECM proteins in the pathogenesis of fibrosis in systemic sclerosis. Investigations into TGF-beta pathways will suggest new treatment strategies for fibrotic diseases.
QIAN
Huan
H
Department of Dermatology and Venereology, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310009, China.
ZHENG
Min
M
D000818:Animals; D005109:Extracellular Matrix / Q000378:metabolism* / Q000473:pathology; D016326:Extracellular Matrix Proteins / Q000378:metabolism; D005347:Fibroblasts / Q000378:metabolism; D005355:Fibrosis; D006801:Humans; D018125:Receptors, Transforming Growth Factor beta / Q000378:metabolism*; D012595:Scleroderma, Systemic / Q000209:etiology* / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000378:metabolism*
D016326:Extracellular Matrix Proteins; D018125:Receptors, Transforming Growth Factor beta; D016212:Transforming Growth Factor beta