title: Study of device use adjusted rates in health care-associated infections after implementation of "bundles" in a closed-model medical intensive care unit.
abstract: "Bundles" strategies improve health care-associated infection (HCAI) rates in medical intensive care units (MICUs). However, few studies have analyzed HCAI rates adjusted for the device removal component of the bundles. An observational study of adult MICU patients while using bundles to prevent HCAIs associated with endovascular catheters, mechanical ventilation, and urinary tract catheters was conducted. The HCAI rates, unadjusted and adjusted for device use, were calculated using incidence rate ratios (unadjusted IRRs [uIRR] and adjusted IRRs [aIRR], respectively). Among 4550 study patients, HCAIs declined from 47 in 2004 to 10 in 2005, 8 in 2006, and 3 in 2007. Catheter-related blood stream infection (CRBSI) rates decreased from 10.77 to 1.67 per 1000 central line days (uIRR, 0.155; 95% confidence interval [CI], 0.13-0.18; P < .0001). Foley-related urinary tract infections (CA-UTI) decreased from 6.23 to 0.63 per 1000 device days (uIRR, 0.1; 95% CI, 0.08-0.19; P < .0001). Ventilator-associated pneumonia (VAP) per 1000 ventilator days diminished from 2.17 to 0.62 (uIRR, 0.29; 95% CI, 0.21-0.38; P < .0001). After adjustment for device use, aIRRs of CRBSI (0.14; 95% CI, 0.11-0.18), UTI (0.09; 95% CI, 0.06-0.12), and VAP (0.33; 95% CI, 0.22-0.47) declined significantly (P < .00001). Implementing comprehensive bundle strategies reduces HCAI beyond the impact of device removal.
authors.affiliation: Critical Care Units, Bronx Lebanon Hospital Center, Bronx, NY 10457, USA. onevenkat@yahoo.com
authors.forename: Sindhaghatta
authors.initials: S
authors.lastname: Venkatram
authors.forename: Sonal
authors.initials: S
authors.lastname: Rachmale
authors.forename: Balavenkatesh
authors.initials: B
authors.lastname: Kanna
mesh_terms: D055499:Catheter-Related Infections / Q000453:epidemiology / Q000209:etiology; D002404:Catheterization / Q000009:adverse effects / Q000706:statistics & numerical data*; D016001:Confidence Intervals; D003428:Cross Infection / Q000453:epidemiology*; D004866:Equipment Contamination; D005260:Female; D006785:Hospitals, University; D006801:Humans; D015994:Incidence; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D009519:New York City / Q000453:epidemiology; D019370:Observation; D053717:Pneumonia, Ventilator-Associated / Q000453:epidemiology / Q000209:etiology; D020379:Risk Adjustment / Q000379:methods* / Q000706:statistics & numerical data*; D014552:Urinary Tract Infections / Q000453:epidemiology / Q000209:etiology; D012122:Ventilators, Mechanical / Q000009:adverse effects / Q000706:statistics & numerical data*