Gene expression changes in normal haematopoietic cells.
The complexity of the healthy haematopoietic system is immense, and as such, one must understand the biology driving normal haematopoietic expression profiles when designing experiments and interpreting expression data that involve normal cells. This article seeks to present an organised approach to the use and interpretation of gene profiling in normal haematopoiesis and broadly illustrates the challenges of selecting appropriate controls for high-throughput expression studies.
Lionberger
Jack M
JM
Genetics and Genomics, Clinical Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N., Seattle, WA 98109, USA. jlionber@fhcrc.org
Stirewalt
Derek L
DL
D000375:Aging / Q000235:genetics; D002454:Cell Differentiation; D004781:Environmental Exposure; D044127:Epigenesis, Genetic / Q000502:physiology; D005260:Female; D015870:Gene Expression / Q000187:drug effects / Q000502:physiology*; D020869:Gene Expression Profiling; D005821:Genetic Techniques; D006412:Hematopoietic Stem Cells / Q000502:physiology; D006413:Hematopoietic System / Q000166:cytology* / Q000502:physiology; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000502:physiology; D020411:Oligonucleotide Array Sequence Analysis; D020543:Proteome / Q000502:physiology; D014157:Transcription Factors / Q000502:physiology
D008565:Membrane Proteins; D020543:Proteome; D014157:Transcription Factors