Regulatory function and expression of rap1gap gene in hematopoietic cells-review.
Rap1 is a small G protein belonging to the RAS superfamily. Rap1 signalling has effects on cell growth, cell proliferation and involves in regulation of the mitogen activated protein (MAP) kinase or ERK (extracellular signal regulated kinase) cascade. Rap1 will directly activate ERK through B-Raf. B-Raf is a member of Raf family, and presents in neuronal and hematopoietic cells. Oncogenic mutations of gene RAS are most frequent and detected in 20% - 30% of human leukemias and 10% - 15% of MDS cases. The review summarizes the regulatory function of Rap1 in development of hematopoietic cells and effect of Rap1 in hematologic malignancies.
Ika
Stella Aprilia
SA
Jiangsu Institute of Hematology, First Hospital, Suzhou University, Suzhou 215006, Jiangsu Province, China.
Qi
Xiao-Fei
XF
Chen
Zi-Xing
ZX
D019337:Hematologic Neoplasms / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D015398:Signal Transduction; D020827:rap1 GTP-Binding Proteins / Q000235:genetics* / Q000378:metabolism*
D020827:rap1 GTP-Binding Proteins