title: Comparison of several sorbents for continuous in situ derivatization and preconcentration of low-molecular mass aldehydes prior to liquid chromatography-tandem mass spectrometric determination in water samples.
abstract: A comparative study of six SPE conventional and non-conventional sorbent materials (silica RP-C18, LiChrolut EN, Amberlite XAD-2, C60 fullerene, multiwall carbon nanotubes and graphitized carbon black) was carried out for the in situ derivatization/preconcentration of eight aldehydes with 2,4-dinitrophenylhydrazine. Although two of the sorbents, LiChrolut EN and RP-C18, turned out to be the most suitable for ultratrace analysis of the aldehydes, LiChrolut EN showed higher capacity for 2,4-dinitrophenylhydrazine trapping (higher efficiency for the in situ derivatization reaction) and superior performance in terms of sensitivity (likely a result of its increased sample breakthrough volume). The LiChrolut EN-based method combined with LC-MS/MS allowed the determination of aldehydes over the linear range of 0.02-15 microg l(-1), with limits of detection at 6-24 ng l(-1) and precision of 3.2-7.2%. The method was applied to determine low-molecular mass aldehydes in water samples. These results indicate that the method proposed is a straightforward and sensitive tool for the determination of these aldehydes in water samples providing better results than those LC-MS/MS reported alternatives in terms of the limit of detection, sample requirements for analysis and cost.
authors.affiliation: Department of Analytical Chemistry, Marie-Curie Building (Annex), Campus of Rabanales, University of Cordoba, E-14071 Cordoba, Spain.
authors.forename: Clara Eugenia
authors.initials: CE
authors.lastname: Baños
authors.forename: Manuel
authors.initials: M
authors.lastname: Silva
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D002853:Chromatography, Liquid; D008970:Molecular Weight; D012117:Resins, Synthetic / Q000737:chemistry*; D052616:Solid Phase Extraction / Q000295:instrumentation* / Q000379:methods*; D053719:Tandem Mass Spectrometry; D014874:Water Pollutants, Chemical / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D012117:Resins, Synthetic; D014874:Water Pollutants, Chemical