title: [Treatment by fat tissue transfer for radiation injury in childhood facial cancer].
abstract: The radiation treatment of malignant facial tumors in children may induce major functional and cosmetic sequelae, mainly due to uneven growth of the bones and soft tissues, resulting in facial asymmetry and hemihypotrophy at adult age. Although fat transfer has proven effective for facial cosmetic treatment, few studies have demonstrated the benefit of the technique in heavily irradiated tissues. The techniques generally used for the treatment of facial asymmetry or hypotrophy are ill-adapted to irradiated patients. Indeed, procedures such as skin detachment, osteotomy and vascular suture are risky because of radiation-induced damage. The aim of the present study was to investigate the potential benefits of fat transfer for the correction of sequelae of facial irradiation. Four patients (two males and two females) aged 27, 25, 16 and 13 years underwent fat grafting for the correction of facial asymmetry or hypotrophy induced by cancer radiation treatment during childhood (radiation dose of more than 50Gy). One to three grafting sessions were required, depending on the cases. After a median follow-up of 3.9 years, cosmetic results were considered satisfactory by both the patient and the surgeon in all four cases. Fat transfer remarkably improved the cosmetic appearance of the patients, without deleterious consequences for the vitality of tissues. In addition, a restoration of skin trophicity was observed, thus confirming the benefit of grafting adipocytes into the irradiated integument. In conclusion, fat grafting appears to be a simple and easily reusable technique which makes it possible to obtain the best morphological and cosmetic results in irradiated patients, whereas avoiding complex and potentially hazardous procedures.
authors.affiliation: Service de chirurgie plastique et reconstructrice, centre Léon-Bérard, Lyon, France. shahlafg@yahoo.com <shahlafg@yahoo.com>
authors.forename: S
authors.initials: S
authors.lastname: Faghahati
authors.forename: T
authors.initials: T
authors.lastname: Delaporte
authors.forename: G
authors.initials: G
authors.lastname: Toussoun
authors.forename: A
authors.initials: A
authors.lastname: Gleizal
authors.forename: F
authors.initials: F
authors.lastname: Morel
authors.forename: E
authors.initials: E
authors.lastname: Delay
mesh_terms: D000273:Adipose Tissue / Q000637:transplantation*; D000293:Adolescent; D000328:Adult; D005153:Facial Neoplasms / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D008297:Male; D011832:Radiation Injuries / Q000601:surgery*; D019651:Plastic Surgery Procedures / Q000379:methods*