title: [Pulmonary and cardiovascular syndrome due to hantavirus: clinical aspects of an emerging disease in southeastern Brazil].
abstract: Pulmonary and cardiovascular syndrome due to hantavirus is a disease caused by inhalation of aerosols from the excreta of wild rodents contaminated by viruses of the Bunyaviridae family. We studied the clinical and laboratory manifestations of 70 cases that occurred in the region of Ribeirão Preto, SP, Brazil, between 1998 and 2007. The frequency of symptoms was as follows: dyspnea (87%), fever (81%), coughing (44%), headache (34%), tachycardia (81%), low arterial blood pressure (56%), metabolic acidosis (57%), lymphocytopenia (51%), hematocrit > 45% (70%), leukocytosis with left deviation (67%), creatinine (51%) and urea (42%). Mortality (54.3%) occurred mainly on the fourth day. Respiratory insufficiency, low arterial blood pressure and shock occurred after 24 to 48 hours. High hematocrit and decreased platelet levels were signs strongly suggestive of the disease. The diagnostic hypothesis of atypical pneumonia was associated with a good prognosis (p = 0.0136). Fluid infusion greater than 2,000 ml and arterial hypotension were associated with a poor prognosis (p = 0.0286 and p = 0.0453).
authors.affiliation: Centro de Pesquisa em Virologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Av Bandeirantes 3900, Ribeirão Preto, SP. gelse@usp.br
authors.forename: Gelse Mazzoni
authors.initials: GM
authors.lastname: Campos
authors.forename: Alessandra Abel
authors.initials: AA
authors.lastname: Borges
authors.forename: Soraya Jabur
authors.initials: SJ
authors.lastname: Badra
authors.forename: Glauciane Garcia
authors.initials: GG
authors.lastname: Figueiredo
authors.forename: Ricardo Luiz Moro de
authors.initials: RL
authors.lastname: Souza
authors.forename: Marcos Lázaro
authors.initials: ML
authors.lastname: Moreli
authors.forename: Luiz Tadeu Moraes
authors.initials: LT
authors.lastname: Figueiredo
mesh_terms: D000328:Adult; D001938:Brazil / Q000453:epidemiology; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000401:mortality* / Q000628:therapy / Q000821:virology; D021821:Communicable Diseases, Emerging / Q000175:diagnosis / Q000401:mortality* / Q000628:therapy / Q000821:virology; D005260:Female; D018804:Hantavirus Pulmonary Syndrome / Q000175:diagnosis / Q000401:mortality* / Q000628:therapy; D006801:Humans; D015994:Incidence; D008297:Male; D011379:Prognosis; D012189:Retrospective Studies; D055815:Young Adult