Characterisation of a novel conjugate of ibuprofen with 3-hydroxybutyric acid oligomers.
OBJECTIVE
A conjugate of ibuprofen with 3-hydroxybutyric acid oligomers has been evaluated as a novel drug delivery model system.


METHODS
This paper focuses on the synthesis and the characterisation of the physicochemical properties of this conjugate, and on hydrolysis studies in aqueous buffers and simulated intestinal fluid. We also describe the development of an analytical method (HPLC) for hydrolysis studies of this compound.


RESULTS
The conjugate had high stability in aqueous solutions of pH 6-8 and underwent slow enzymatic hydrolysis.


CONCLUSIONS
This conjugate is not well suited for oral administration but might be considered a candidate for development of prodrug preparations for parenteral or topical sustained release.
Stasiak
Pawel
P
Department of Pharmaceutical Technology, Medical University of Gdansk, Poland.
Ehrhardt
Carsten
C
Juzwa
Maria
M
Sznitowska
Malgorzata
M
D020155:3-Hydroxybutyric Acid / Q000737:chemistry*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D003692:Delayed-Action Preparations; D004355:Drug Stability; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D007052:Ibuprofen / Q000008:administration & dosage / Q000737:chemistry*; D011355:Prodrugs / Q000737:chemistry; D012995:Solubility
D000894:Anti-Inflammatory Agents, Non-Steroidal; D003692:Delayed-Action Preparations; D011355:Prodrugs; D020155:3-Hydroxybutyric Acid; D007052:Ibuprofen