Rostral ventral medulla cholinergic mechanism in pain-induced analgesia.
The ascending nociceptive control (ANC), a novel spinostriatal pain modulation pathway, mediates a form of pain-induced analgesia referred to as noxious stimulus-induced antinociception (NSIA). ANC includes specific spinal cord mechanisms as well as circuitry in nucleus accumbens, a major component of the ventral striatum. Here, using the trigeminal jaw-opening reflex (JOR) in the rat as a nociceptive assay, we show that microinjection of the nicotinic acetylcholine receptor (nAChR) antagonist mecamylamine into the rostral ventral medulla (RVM) blocks NSIA, implicating RVM as a potentially important link between ANC and the PAG-RVM-spinal descending pain modulation system. A circuit connecting nucleus accumbens to the RVM is proposed as a novel striato-RVM pathway.
Gear
Robert W
RW
Department of Oral and Maxillofacial Surgery, University of California, San Francisco, California 94143-0440, United States. robert.gear@ucsf.edu
Levine
Jon D
JD
D000698:Analgesia; D000818:Animals; D004576:Electromyography; D008297:Male; D008464:Mecamylamine / Q000008:administration & dosage / Q000494:pharmacology; D008526:Medulla Oblongata / Q000378:metabolism*; D008845:Microinjections; D009434:Neural Pathways; D018733:Nicotinic Antagonists / Q000008:administration & dosage / Q000494:pharmacology; D010146:Pain / Q000378:metabolism* / Q000503:physiopathology; D010147:Pain Measurement; D051381:Rats; D017207:Rats, Sprague-Dawley; D011978:Receptors, Nicotinic / Q000502:physiology*; D012018:Reflex; D014276:Trigeminal Nerve / Q000503:physiopathology
D018733:Nicotinic Antagonists; D011978:Receptors, Nicotinic; D008464:Mecamylamine
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