Coagulation and anticoagulation in pulmonary arterial hypertension.
Pulmonary arterial hypertension is a complex pulmonary vascular disease with a broad range of abnormal vascular abnormalities. Vasoconstriction, remodeling and thrombosis contribute to some extent to increased pulmonary vascular resistance and pressure. This review presents current knowledge on the role of the thrombotic process in the pathogenesis of PAH and evaluates the rationale for anticoagulation therapy.
Berger
Gidon
G
Division for Pulmonary Medicine, Rambam Health Care Campus, Haifa, Israel. g_berger@rambam.health.gov.il
Azzam
Zaher S
ZS
Hoffman
Ron
R
Yigla
Mordechai
M
D000925:Anticoagulants / Q000627:therapeutic use*; D001777:Blood Coagulation; D001792:Blood Platelets / Q000502:physiology; D004730:Endothelium, Vascular / Q000503:physiopathology; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D013923:Thromboembolism / Q000188:drug therapy*; D014661:Vasoconstriction
D000925:Anticoagulants