title: CT colonography with minimal bowel preparation: evaluation of tagging quality, patient acceptance and diagnostic accuracy in two iodine-based preparation schemes.
abstract: OBJECTIVE
  The aim of this study was to compare a 1-day with a 2-day iodine bowel preparation for CT colonography in a positive faecal occult blood test (FOBT) screening population.
  
  
  METHODS
  One hundred consecutive patients underwent CT colonography and colonoscopy with segmental unblinding. The first 50 patients (group 1) ingested 7 50 ml iodinated contrast starting 2 days before CT colonography. The latter 50 patients (group 2) ingested 4 50 ml iodinated contrast starting 1 day before CT colonography. Per colonic segment measurements of residual stool attenuation and homogeneity were performed, and a subjective evaluation of tagging quality (grade 1-5) was done. Independently, two reviewers performed polyp and carcinoma detection.
  
  
  RESULTS
  The tagging density was 638 and 618 HU (p = 0.458) and homogeneity 91 and 86 HU for groups 1 and 2, respectively (p = 0.145). The tagging quality was graded 5 (excellent) in 90% of all segments in group 1 and 91% in group 2 (p = 0.749). Mean per-polyp sensitivity for lesions >or=10 mm was 86% in group 1 and 97% in group 2 (p = 0.355). Patient burden from diarrhoea significantly decreased for patients in group 2.
  
  
  CONCLUSIONS
  One-day preparation with meglumine ioxithalamate results in an improved patient acceptability compared with 2-day preparation and has a comparable, excellent image quality and good diagnostic performance.
authors.affiliation: Department of Radiology, Academic Medical Centre, Amsterdam, The Netherlands, M.H.Liedenbaum@amc.uva.nl
authors.forename: Marjolein H
authors.initials: MH
authors.lastname: Liedenbaum
authors.forename: A H
authors.initials: AH
authors.lastname: de Vries
authors.forename: C I B F
authors.initials: CI
authors.lastname: Gouw
authors.forename: A F
authors.initials: AF
authors.lastname: van Rijn
authors.forename: S
authors.initials: S
authors.lastname: Bipat
authors.forename: E
authors.initials: E
authors.lastname: Dekker
authors.forename: J
authors.initials: J
authors.lastname: Stoker
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001294:Attitude to Health; D023881:Colonography, Computed Tomographic / Q000379:methods*; D015179:Colorectal Neoplasms / Q000000981:diagnostic imaging*; D003287:Contrast Media; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007422:Intestines / Q000000981:diagnostic imaging*; D007482:Iothalamate Meglumine; D008297:Male; D008875:Middle Aged; D010342:Patient Acceptance of Health Care; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; C001694:meglumine ioxithalamate; D007482:Iothalamate Meglumine
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