Nanodoublers as deep imaging markers for multi-photon microscopy.
We demonstrate the possibility to excite second-harmonic (SH) active Fe(IO(3))(3) nanocrystals with two distinct laser sources at 800 and 1550 nm, and we show, by a complementary experimental and numerical study, how the wavelength flexibility inherent to non-phase-matched SH nanoparticles can be efficiently exploited to increase imaging penetration depth of markers embedded in biological samples.
Extermann
Jerome
J
Université de Genève, GAP-Biophotonics, 20 rue de l'Ecole de Médecine, 1211 Geneva, Switzerland.
Bonacina
Luigi
L
Cuña
Enrique
E
Kasparian
Christelle
C
Mugnier
Yannick
Y
Feurer
Thomas
T
Wolf
Jean-Pierre
JP
D000818:Animals; D003198:Computer Simulation; D007501:Iron / Q000737:chemistry; D007834:Lasers; D051379:Mice; D008853:Microscopy / Q000379:methods; D036641:Microscopy, Fluorescence, Multiphoton / Q000379:methods*; D009010:Monte Carlo Method; D053758:Nanoparticles / Q000737:chemistry; D036103:Nanotechnology / Q000379:methods*; D009391:Nephelometry and Turbidimetry / Q000379:methods; D055095:Optics and Photonics; D017785:Photons; D011137:Polystyrenes / Q000737:chemistry
D011137:Polystyrenes; D007501:Iron