title: Mantle cell lymphoma: are current therapies changing the course of disease?
abstract: Mantle cell lymphoma (MCL) is a rare entity of non-Hodgkin's lymphoma, although it seems to be increasing in incidence and severity. There is no accepted standard therapy; however, one controlled clinical trial demonstrated that intensive induction immunochemotherapy followed by high-dose radiochemotherapy and autologous stem cell transplantation was superior to conventional treatment. Moreover, uncontrolled studies of intensive immunochemotherapy followed by autologous stem cell transplantation now suggest that MCL may be cured. Insight into the biology of MCL is expanding, opening new avenues of treatment with well-defined molecular targets, including CD20, mammalian target of rapamycin, and proteasomes.
authors.affiliation: Department of Hematology 4042, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark. Christian.geisler@rh.regionh.dk
authors.forename: Christian
authors.initials: C
authors.lastname: Geisler
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D006801:Humans; D020522:Lymphoma, Mantle-Cell / Q000473:pathology / Q000628:therapy*; D011878:Radiotherapy / Q000379:methods*; D033581:Stem Cell Transplantation / Q000379:methods*; D016019:Survival Analysis; D014182:Transplantation, Autologous; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents
references.citation: Bone Marrow Transplant. 2009 Mar;43(6):509-11
references.pmid: 18955979
references.citation: Curr Opin Hematol. 2007 Nov;14(6):632-8
references.pmid: 17898567
references.citation: J Clin Oncol. 2005 May 20;23(15):3383-9
references.pmid: 15908650
references.citation: Bone Marrow Transplant. 2007 Dec;40(11):1007-17
references.pmid: 17922042
references.citation: Br J Haematol. 2009 Feb;144(4):524-30
references.pmid: 19036081
references.citation: Br J Haematol. 2005 Oct;131(1):29-38
references.pmid: 16173960
references.citation: J Clin Oncol. 2000 Jan;18(2):317-24
references.pmid: 10637245
references.citation: Nat Rev Cancer. 2007 Oct;7(10):750-62
references.pmid: 17891190
references.citation: J Clin Oncol. 2005 Mar 20;23(9):1984-92
references.pmid: 15668467
references.citation: J Natl Cancer Inst. 2007 May 2;99(9):706-14
references.pmid: 17470738
references.citation: Blood. 2004 Nov 15;104(10):3064-71
references.pmid: 15284112
references.citation: Blood. 2004 Dec 1;104(12):3535-42
references.pmid: 15304387
references.citation: Hematol Oncol. 2009 Sep;27(3):154-9
references.pmid: 19274614
references.citation: J Clin Oncol. 2005 Oct 1;23(28):7013-23
references.pmid: 16145068
references.citation: Blood. 1996 Jun 1;87(11):4483-94
references.pmid: 8639814
references.citation: J Clin Oncol. 2009 Feb 1;27(4):511-8
references.pmid: 19075279
references.citation: Blood. 2008 Jan 15;111(2):558-65
references.pmid: 17962512
references.citation: Blood. 2006 Dec 15;108(13):4003-8
references.pmid: 16946304
references.citation: J Clin Oncol. 2005 Aug 10;23(23):5347-56
references.pmid: 15983389
references.citation: J Clin Oncol. 2002 Mar 1;20(5):1288-94
references.pmid: 11870171
references.citation: J Clin Oncol. 2005 Feb 1;23(4):705-11
references.pmid: 15598978
references.citation: Blood. 2008 Oct 1;112(7):2687-93
references.pmid: 18625886
references.citation: Invest New Drugs. 2009 Oct;27(5):476-81
references.pmid: 18953490
references.citation: Eur J Haematol. 2003 Aug;71(2):73-80
references.pmid: 12890145
references.citation: Bone Marrow Transplant. 1998 Oct;22(7):645-50
references.pmid: 9818691
references.citation: Cancer. 2008 Aug 15;113(4):791-8
references.pmid: 18615506
references.citation: Am J Surg Pathol. 2006 Oct;30(10):1274-80
references.pmid: 17001159
references.citation: Leukemia. 2002 Apr;16(4):587-93
references.pmid: 11960337
references.citation: J Clin Oncol. 1998 May;16(5):1922-30
references.pmid: 9586911
references.citation: J Clin Oncol. 2009 Mar 10;27(8):1209-13
references.pmid: 19188674
references.citation: J Clin Oncol. 2008 Jan 1;26(1):90-5
references.pmid: 18025438
references.citation: Blood. 1997 Jun 1;89(11):3909-18
references.pmid: 9166827
references.citation: J Clin Oncol. 2008 Mar 20;26(9):1544-52
references.pmid: 18285605
references.citation: Blood. 2008 Feb 15;111(4):2385-7
references.pmid: 18077791
references.citation: Cancer. 2008 Aug 1;113(3):508-14
references.pmid: 18543327
references.citation: Leuk Lymphoma. 2009 Mar;50(3):463-5
references.pmid: 19197732
references.citation: Br J Haematol. 2009 Apr;145(1):34-9
references.pmid: 19220284
references.citation: J Clin Oncol. 1998 Dec;16(12):3803-9
references.pmid: 9850025
references.citation: Blood. 2009 Apr 30;113(18):4144-52
references.pmid: 19168784
references.citation: Blood. 2005 Apr 1;105(7):2677-84
references.pmid: 15591112
references.citation: Haematologica. 2007 Jan;92(1):42-9
references.pmid: 17229634
references.citation: Biol Blood Marrow Transplant. 2006 Dec;12(12):1270-6
references.pmid: 17162208
references.citation: Ann Oncol. 2009 Mar;20(3):520-5
references.pmid: 19074748
references.citation: Br J Haematol. 2009 May;145(3):344-9
references.pmid: 19245430
references.citation: J Clin Oncol. 2008 Oct 20;26(30):4966-72
references.pmid: 18606985