title: Neurohormonal and echocardiographic results after CorCap and mitral annuloplasty for dilated cardiomyopathy.
abstract: BACKGROUND
  Restrictive mitral annuloplasty (RMA) can be an effective treatment for functional mitral regurgitation in congestive heart failure (CHF). Passive cardiac restraint is another surgical approach, but the midterm results are not well characterized.
  
  
  METHODS
  Thirty patients with functional mitral regurgitation were prospectively randomized to RMA alone or cardiac restraint with the CorCap Cardiac Support Device (Acorn Cardiovascular Inc, St. Paul, MN) and RMA. Clinical, echocardiographic, New York Heart Association (NYHA) functional class, Short Form 36-Item Health Survey (SF-36) quality of life scores, and N-terminal pro-B-type natriuretic peptide (NT-proBNP) results were analyzed.
  
  
  RESULTS
  No hospital deaths or device-related complications occurred. The two groups had comparable morbidity (p = 0.34). Echocardiography showed a trend towards a slightly better functional improvement during follow-up in CorCap plus RMA patients (between groups, p = 0.001). Both groups showed improved results for SF-36, NYHA, and NT-pro.BNP; however, CorCap plus RMA patients had significantly better SF-36 at discharge (p = 0.003), postoperative NYHA (p = 0.05), and NT-pro.BNP (p = 0.001). Survival (p = 0.46), freedom from CHF (p = 0.23), and rehospitalization (p = 0.28) were comparable. Patients in whom CHF developed after postoperative day 1 had higher NT-pro.BNP values (p = 0.001 at all time-points).
  
  
  CONCLUSIONS
  Adjunctive application of CorCap with RMA correlated with better NT-pro.BNP at short-term follow-up together with slightly improved echocardiographic and functional results. This deserves further evaluation at midterm and long-term follow-up. Reduction of NT-pro.BNP at follow-up may be suggested as a prognostic index.
authors.affiliation: Cardiac Surgery Unit, Magna Graecia University of Catanzaro, Catanzaro, Italy. cchumg@hotmail.it
authors.forename: Antonio S
authors.initials: AS
authors.lastname: Rubino
authors.forename: Francesco
authors.initials: F
authors.lastname: Onorati
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Santarpino
authors.forename: Eugenia
authors.initials: E
authors.lastname: Pasceri
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Santarpia
authors.forename: Lucia
authors.initials: L
authors.lastname: Cristodoro
authors.forename: Giuseppe Filiberto
authors.initials: GF
authors.lastname: Serraino
authors.forename: Attilio
authors.initials: A
authors.lastname: Renzulli
mesh_terms: D000368:Aged; D002311:Cardiomyopathy, Dilated / Q000097:blood / Q000000981:diagnostic imaging / Q000401:mortality / Q000601:surgery*; D003131:Combined Modality Therapy; D004452:Echocardiography; D018618:Echocardiography, Doppler, Color; D017548:Echocardiography, Transesophageal; D005260:Female; D005500:Follow-Up Studies; D006333:Heart Failure / Q000097:blood / Q000000981:diagnostic imaging / Q000401:mortality / Q000601:surgery*; D006350:Heart Valve Prosthesis; D006353:Heart-Assist Devices; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000000981:diagnostic imaging / Q000601:surgery*; D008944:Mitral Valve Insufficiency / Q000097:blood / Q000000981:diagnostic imaging / Q000401:mortality / Q000601:surgery*; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D011091:Polyesters; D011183:Postoperative Complications / Q000097:blood / Q000000981:diagnostic imaging / Q000401:mortality; D013526:Surgical Mesh; D018487:Ventricular Dysfunction, Left / Q000097:blood / Q000000981:diagnostic imaging / Q000401:mortality / Q000601:surgery*
chemical_list: D010446:Peptide Fragments; D011091:Polyesters; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain