Hybrid lipids as a biological surface-active component.
Cell membranes contain small domains (on the order of nanometers in size, sometimes called rafts) of lipids whose hydrocarbon chains are more ordered than those of the surrounding bulk-phase lipids. Whether these domains are fluctuations, metastable, or thermodynamically stable, is still unclear. Here, we show theoretically how a lipid with one saturated hydrocarbon chain that prefers the ordered environment and one partially unsaturated chain that prefers the less ordered phase, can act as a line-active component. We present a unified model that treats the lipids in both the bulk and at the interface and show how they lower the line tension between domains, eventually driving it to zero at sufficiently large interaction strengths or at sufficiently low temperatures. In this limit, finite-sized domains stabilized by the packing of these hybrid lipids can form as equilibrium structures.
Brewster
R
R
Weizmann Institute of Science, Department of Materials and Interfaces, Rehovot, Israel.
Pincus
P A
PA
Safran
S A
SA
D003198:Computer Simulation; D008051:Lipid Bilayers / Q000737:chemistry*; D008560:Membrane Fluidity; D021962:Membrane Microdomains / Q000737:chemistry*; D008956:Models, Chemical; D013500:Surface Tension; D013501:Surface-Active Agents / Q000737:chemistry*
D008051:Lipid Bilayers; D013501:Surface-Active Agents
Biochim Biophys Acta. 2007 Nov;1768(11):2777-86
17931595
Biophys J. 2008 Nov 15;95(10):4756-62
18708463
J Mol Biol. 2005 Mar 4;346(4):1109-20
15701521
Biophys J. 1993 Oct;65(4):1396-403
8274633
Annu Rev Biophys Biomol Struct. 2003;32:257-83
12543707
ACS Chem Biol. 2008 May 16;3(5):287-93
18484709
Phys Rev Lett. 2005 Oct 14;95(16):168301
16241845
Chem Phys Lipids. 2005 Jul;136(1):55-66
15927174
Phys Rev E Stat Nonlin Soft Matter Phys. 2006 Mar;73(3 Pt 1):031918
16605569
J Am Chem Soc. 2006 Jan 11;128(1):192-201
16390147
Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics. 1996 Mar;53(3):2670-2683
9964554
Biophys J. 2004 Jun;86(6):4075-93
15189902
Biophys J. 2006 Mar 1;90(5):1639-49
16326903
Nature. 1997 Jun 5;387(6633):569-72
9177342
Phys Rev E Stat Nonlin Soft Matter Phys. 2008 Feb;77(2 Pt 1):021907
18352051
Phys Rev Lett. 1990 Nov 19;65(21):2736-2739
10042679
Arch Biochem Biophys. 1969 May;131(2):495-501
5787218
Biophys J. 2004 Mar;86(3):1345-56
14990465
Biophys J. 2005 Feb;88(2):1120-33
15542550
J Lipid Res. 1968 Jan;9(1):65-7
5637431
J Cell Biol. 2002 Jun 10;157(6):1071-81
12058021
Biophys J. 2007 Nov 1;93(9):3169-81
17644560
Biophys J. 2008 Jul;95(1):236-46
18424504
Phys Rev Lett. 2008 May 16;100(19):198103
18518492
Phys Rev Lett. 2006 Mar 10;96(9):098101
16606318
J Chem Phys. 2005 Jan 22;122(4):44904
15740295
Nature. 2003 Oct 23;425(6960):821-4
14574408
J Phys Chem B. 2007 Sep 27;111(38):11091-4
17764170
Phys Rev E Stat Nonlin Soft Matter Phys. 2007 Jan;75(1 Pt 1):011919
17358196
Phys Rev Lett. 2002 Dec 23;89(26):268101
12484857
Biochim Biophys Acta. 2005 Dec 30;1746(3):172-85
16043244
J Phys Chem B. 2008 Mar 27;112(12):3807-11
18307337
Can J Physiol Pharmacol. 1968 May;46(3):511-24
5698921
Biophys J. 2007 Nov 1;93(9):3113-9
17660324
Biophys J. 2006 Jul 1;91(1):189-205
16617071
J Mol Biol. 2007 Nov 16;374(1):162-9
17920625
Annu Rev Biophys Biomol Struct. 2007;36:63-77
17201675
Biophys J. 2008 Oct;95(7):3295-305
18621818
J Biol Phys. 2002 Jun;28(2):195-210
23345769
Biochim Biophys Acta. 2009 Jan;1788(1):47-52
18805392
Phys Rev Lett. 2007 May 18;98(20):208102
17677743
Lipids. 1969 Nov;4(6):466-72
4312743
Nat Rev Mol Cell Biol. 2006 Jun;7(6):456-62
16625153