title: Retiform hemangioendothelioma: presentation of a case expressing D2-40.
abstract: Retiform hemangioendothelioma (RH) is a low-grade angiosarcoma with low metastatic risk, usually occurring as a single lesion on the trunk or extremity in middle-aged adults. Histopathology shows a distinctive pattern with arborizing blood vessels arranged in a retiform pattern (similar to rete testis tissue) and focal papillae with fibrosclerotic (hyaline) cores. The blood vessels are lined by comparatively monomorphic endothelial cells, frequently presenting a hobnail pattern. We report a case of RH presenting as an indolent brownish plaque on the back of a 17-year-old male. Surgical resection and sentinel lymph node biopsy showed no evidence of metastasis. In contrast to the recent literature, this case of RH showed positivity for D2-40, a marker of lymphatic endothelium. We also report ultrastructural findings for this case of RH.
authors.affiliation: Department of Dermatology, Paracelsus Private Medical University, Salzburg, Austria. m.emberger@aon.at; m.emberger@salk.at
authors.forename: Michael
authors.initials: M
authors.lastname: Emberger
authors.forename: Martin
authors.initials: M
authors.lastname: Laimer
authors.forename: Hansjörg
authors.initials: H
authors.lastname: Steiner
authors.forename: Bernhard
authors.initials: B
authors.lastname: Zelger
mesh_terms: D000293:Adolescent; D000911:Antibodies, Monoclonal / Q000378:metabolism*; D058846:Antibodies, Monoclonal, Murine-Derived; D014408:Biomarkers, Tumor / Q000032:analysis; D006390:Hemangioendothelioma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008297:Male; D046529:Microscopy, Electron, Transmission; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery
chemical_list: D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D014408:Biomarkers, Tumor; C500987:monoclonal antibody D2-40