May alcohol-induced increase of HDL be considered as atheroprotective?
It is well known that the consumption of moderate doses of alcohol leads to the increase of HDL-cholesterol (HDL-C). Atheroprotectivity of HDL particles is based primarily on their role in reverse cholesterol transport (RCT). In the study with a cross-over design 13 male volunteers were studied in two different regimens: i) drinking of 36 g alcohol daily and ii) drinking only non-alcoholic beverages, to test whether alcohol-induced increase of HDL cholesterol can affect cholesterol efflux (CHE) from cell culture of labeled human macrophages. Alcohol consumption induced significant (p < 0.05) increases of HDL cholesterol from 1.25 +/- 0.32 to 1.34 +/- 0.38 mmol/l and Apo A1 from 1.34 +/- 0.16 to 1.44 +/- 0.19 g/l. These changes were combined with a slight increase of cholesterol efflux from 13.8 +/- 2.15 to 14.9 +/- 1.85 % (p = 0.059). There were significant correlations between individual changes of HDL-C and Apo A1 concentrations and individual changes of CHE (0.51 and 0.60, respectively). In conclusion, moderate alcohol consumption changes the capacity of plasma to induce CHE only at a border line significance.
Králová Lesná
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Institute for Clinical and Experimental Medicine - IKEM, Centre for Cardiovascular Research, Prague, Czech Republic. ivka@medicon.cz
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Stávek
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D000328:Adult; D000428:Alcohol Drinking / Q000097:blood*; D016632:Apolipoprotein A-I / Q000097:blood*; D050197:Atherosclerosis / Q000097:blood / Q000517:prevention & control*; D001515:Beer; D001692:Biological Transport; D015415:Biomarkers / Q000097:blood; D002478:Cells, Cultured; D008076:Cholesterol, HDL / Q000097:blood*; D018592:Cross-Over Studies; D006801:Humans; D008264:Macrophages / Q000378:metabolism; D008297:Male; D015854:Up-Regulation
C505693:APOA1 protein, human; D016632:Apolipoprotein A-I; D015415:Biomarkers; D008076:Cholesterol, HDL