title: Giant nodular pseudoangiomatous stromal hyperplasia (PASH) of the breast presenting as a rapidly growing tumour.
abstract: Pseudoangiomatous stromal hyperplasia (PASH) is often a microscopic incidental finding in breast biopsies performed for benign or malignant diseases. In rare cases, it presents as a localised breast mass. Since Vuitch et al first described this condition in 1986, only 109 cases of PASH presenting as a palpable or mammographically detectable mass have been documented. PASH is characterised by a dense, collagenous proliferation of mammary stroma, forming inter-anastomosing capillary-like spaces. It is important to distinguish this benign lesion from a low-grade angiosarcoma. Here we describe the clinical, radiological and histological features of a very unusual case of PASH that presented as a rapidly growing breast lesion in a 37-year old woman.
authors.affiliation: General Surgery 1, Azienda Ospedaliera G. Salvini, Ospedale di Rho, Milano.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Mezzabotta
authors.forename: Silvia
authors.initials: S
authors.lastname: Riccardi
authors.forename: Simona
authors.initials: S
authors.lastname: Bonvini
authors.forename: Paolo
authors.initials: P
authors.lastname: Declich
authors.forename: Enrico
authors.initials: E
authors.lastname: Tavani
authors.forename: Eugenio
authors.initials: E
authors.lastname: Morandi
mesh_terms: D000328:Adult; D000798:Angiomatosis / Q000473:pathology* / Q000601:surgery*; D001941:Breast Diseases / Q000473:pathology* / Q000601:surgery*; D001943:Breast Neoplasms / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000601:surgery; D033162:Incidental Findings; D017154:Stromal Cells / Q000473:pathology*; D016896:Treatment Outcome