title: [Results of adjuvant chemoradiation after curative surgery for gastric cancer: a retrospective study].
abstract: BACKGROUND
  Survival rates after curative surgery for gastric cancer are disappointing. Therefore adjuvant therapeutic strategies are required.
  
  
  OBJECTIVE
  To analyze survival and side effects of treatment among gastric cancer patients treated with adjuvant chemo radiotherapy after curative resection of gastric adenocarcinoma.
  
  
  METHODS
  Retrospective review of medical records of 74 patients aged 20 to 74 years, treated with complete resection of gastric adenocarcinoma followed by adjuvant chemo radiation. Survival analysis was based on the records and information from the National Mortality Registry.
  
  
  RESULTS
  Five years survival fluctuated from 50% among patients in stage IB to 25% among those is stage IV. Significant acute toxicity was observed in 23 patients (31%). No patients died due to acute toxicity. Eleven patients (16.4%) developed significant late toxicity, with two possible deaths related to treatment.
  
  
  CONCLUSIONS
  Postoperative chemo radiotherapy is feasible in our experience. Continues infusion of 5-fluoruracil is recommended to reduce toxicity.
authors.affiliation: Servicio de Oncología Médica, Instituto Nacional del Cáncer, Santiago, Chile. bmuller@incancer.cl
authors.forename: Bettina
authors.initials: B
authors.lastname: Müller
authors.forename: Paulina
authors.initials: P
authors.lastname: Balbontín
authors.forename: Marcela
authors.initials: M
authors.lastname: Cárcamo
authors.forename: Cristian
authors.initials: C
authors.lastname: Trujillo
authors.forename: Sergio
authors.initials: S
authors.lastname: Becerra
authors.forename: Antonio
authors.initials: A
authors.lastname: Solá
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Neveu
authors.forename: Roberto
authors.initials: R
authors.lastname: Fernández
authors.forename: Martín
authors.initials: M
authors.lastname: Buchholtz
authors.forename: Luis
authors.initials: L
authors.lastname: Villanueva
authors.forename: Berta
authors.initials: B
authors.lastname: Cerda
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000628:therapy*; D000328:Adult; D000368:Aged; D017024:Chemotherapy, Adjuvant / Q000009:adverse effects; D018572:Disease-Free Survival; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D018714:Radiotherapy, Adjuvant / Q000009:adverse effects; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000401:mortality / Q000628:therapy*; D016019:Survival Analysis; D016896:Treatment Outcome; D055815:Young Adult