Prediction of biochemical failure in localized carcinoma of prostate after radical prostatectomy by neuro-fuzzy.
OBJECTIVE
To predict biochemical failure in localized prostate cancer after radical prostatectomy using preoperative variables.


METHODS
Twenty-six patients of early carcinoma of prostate underwent open retropubic radical prostatectomy from June 2002 to June 2006. Preoperative variables included age, family history, digital rectal examination, serum prostatic specific antigen (S. PSA), prostate biopsy Gleason score, MRI of pelvis variables like periprostatic extension, seminal vesical invasion, weight of gland and pathological stage. With application of neuro-fuzzy, these variables were fed into system as input and output, that is S. PSA at six months (predicted value) was calculated. Neuro-fuzzy system is a system to combine fuzzy system with learning techniques derived from neural networks. Here, we applied Takagi Sugeno Kang model (TSK) due to its close solution to our aim. All the patients were followed up for a minimum of six months. At six month S. PSA of all patients was done (observed value). Predicted and observed values were compared.


RESULTS
Predicted and observed values were plotted on 1:1 slop line. Coefficient of correlation was 0.9935.


CONCLUSIONS
Coefficient of correlation is close to one. It indicates that the neuro-fuzzy is accurate in predicting biochemical failure in localized carcinoma of prostate after radical prostatectomy.
Goyal
Neeraj Kumar
NK
Department of Urology, Institute of Medical Sciences, Banaras Hindu University, Varanasi - 221 005, India.
Kumar
Abhay
A
Acharya
Rajiba L
RL
Dwivedi
Udai Shankar
US
Trivedi
Sameer
S
Singh
Pratap Bahadur
PB
Singh
T N
TN
J Urol. 1996 Jul;156(1):137-43
8648775
BJU Int. 1999 Aug;84(3):316-23
10468729
J Urol. 2001 May;165(5):1562-8
11342918
J Urol. 1995 Jul;154(1):131-8
7539857
Urology. 2006 Aug;68(2):357-61
16904452
J Urol. 2004 Oct;172(4 Pt 1):1306-10
15371829
Int Braz J Urol. 2005 Sep-Oct;31(5):445-51
16255790
BJU Int. 2004 Mar;93(5):680-8
15009088
Clin Cancer Res. 2003 Sep 15;9(11):4172-7
14519642
J Urol. 2003 Feb;169(2):517-23
12544300