Cardiac regenerative potential of adipose tissue-derived stem cells.
Myocyte loss due to ischemia/reperfusion injury leads to cardiac dysfunction and heart failure, and the concentration of current therapy is limited on preventing the progression. Recent interest has focused on transplantation of stem cells to differentiate and replenish the loss of myocytes. Adipose tissue represents an alternative and abundant source of adult stem cells with the ability to differentiate along multiple lineage pathways. Recent studies have demonstrated the potential of adipose tissue-derived stem cells for treatment of acute myocardial infarction. The aim of this review is to discuss the potential therapeutic benefits of adipose tissue-derived stem cells in improving cardiac function post-injury.
Hoke
N N
NN
Department of Internal Medicine, Division of Cardiology, Virginia Commonwealth University, 1101 E. Marshall Street, Richmond, VA 23298-0281, USA.
Salloum
F N
FN
Loesser-Casey
K E
KE
Kukreja
Rakesh C
RC
D000273:Adipose Tissue / Q000166:cytology*; D000328:Adult; D053687:Adult Stem Cells / Q000637:transplantation*; D000818:Animals; D002454:Cell Differentiation; D019070:Cell Lineage; D049109:Cell Proliferation; D002470:Cell Survival; D042783:Endothelial Cells / Q000473:pathology*; D006801:Humans; D017202:Myocardial Ischemia / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D032383:Myocytes, Cardiac / Q000473:pathology*; D018919:Neovascularization, Physiologic; D012038:Regeneration; D033581:Stem Cell Transplantation; D016896:Treatment Outcome