Relationship between C-reactive protein concentration and cytokine responses to exercise in healthy and illness-prone runners.
Differences in the immune and inflammatory response to exercise between healthy and illness-prone athletes may be one explanation why some athletes experience a greater incidence of upper respiratory symptoms than others. The aim of this study was to compare the C-reactive protein (CRP) response to acute exercise between healthy and illness-prone trained distance runners. Runners were classified as healthy (< or =2 episodes of upper respiratory symptoms per year; n = 10) or illness-prone (> or =4 episodes per year; n = 8) and completed three treadmill running protocols. CRP concentrations were determined prior to and 24 h following each exercise protocol and responses compared between the two groups. Plasma concentrations of Interleukin (IL)-6, IL-8, IL-10 and the IL-1 receptor antagonist (IL-1ra) were also determined immediately, 1 h, 10 h and 24 h post-exercise. The CRP response at 24 h post-exercise was not substantially different between healthy and illness-prone athletes (approximately 2-10%). There were small to moderate correlations between resting CRP concentrations and the peak IL-6 (r = 0.28, P = 0.04), IL-8 (r = 0.31, P = 0.03), IL-10 (r = 0.28, P = 0.05) and IL-1ra (r = 0.30, P = 0.03) concentrations post-exercise. The CRP response to exercise was not useful in distinguishing between healthy and illness-prone athletes. The relationship between resting CRP concentrations and the peak pro- and anti-inflammatory responses to exercise supports the likely involvement of CRP in the complex network regulating exercise-induced inflammatory disturbance.
Cox
Amanda J
AJ
Department of Physiology, Australian Institute of Sport, Canberra, ACT 2616, Australia. amanda.cox@newcastle.edu.au
Pyne
David B
DB
Gleeson
Maree
M
Callister
Robin
R
D002097:C-Reactive Protein / Q000032:analysis* / Q000378:metabolism; D016207:Cytokines / Q000097:blood* / Q000378:metabolism; D004198:Disease Susceptibility / Q000097:blood* / Q000276:immunology / Q000378:metabolism; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D006262:Health; D006801:Humans; D008297:Male; D009994:Osmolar Concentration; D005082:Physical Exertion / Q000502:physiology; D012420:Running / Q000502:physiology; D013997:Time Factors
D016207:Cytokines; D002097:C-Reactive Protein
Clin J Sport Med. 2008 Sep;18(5):438-45
18806552
Med Hypotheses. 2004;62(4):499-506
15050096
Med Sci Sports Exerc. 2007 Nov;39(11):1918-26
17986898
Br J Sports Med. 2005 Mar;39(3):171-7; discussion 171-7
15728699
Br J Sports Med. 2006 Feb;40(2):124-7
16431998
J Clin Invest. 2003 Jun;111(12):1805-12
12813013
J Exp Med. 1993 Nov 1;178(5):1629-36
7693853
Eur J Appl Physiol Occup Physiol. 1997;75(1):47-53
9007457
J Biol Chem. 2004 Nov 19;279(47):48487-90
15337754
Eur J Appl Physiol. 2003 May;89(3-4):344-51
12736844
Mol Immunol. 2001 Aug;38(2-3):189-97
11532280