title: Angiotensins and Alzheimer's disease: a bench to bedside overview.
abstract: The pathology of Alzheimer's disease (AD) features amyloid beta peptide deposition, intracellular neurofibrillary tangles and deficits in the cholinergic pathway. Abnormal blood pressure is recognised as a risk factor for the development of AD, although the underlying mechanisms remain unproven. This review proposes angiotensins and associated enzymatic pathways as important mediators of recognised but undefined links between blood pressure and AD. Evidence in support of this involvement translates consistently from the most basic in vitro, in vivo and ex vivo experimental paradigms to more complex human-based observational and experimental studies, which also fortunately offer potential for therapeutic interventions against AD.
authors.affiliation: Dementia Research Group, Institute of Clinical Neurosciences, Department of Clinical Science at North Bristol, University of Bristol, Frenchay Hospital, Bristol BS16 1LE, UK. Patrick.Kehoe@bristol.ac.uk.
authors.forename: Patrick G
authors.initials: PG
authors.lastname: Kehoe
references.citation: Biol Psychiatry. 1986 Dec;21(14):1365-81
references.pmid: 3024746
references.citation: Drugs Aging. 2002;19(10):723-32
references.pmid: 12390049
references.citation: BMC Neurosci. 2008 Dec 03;9 Suppl 2:S14
references.pmid: 19090987
references.citation: Neurol Res. 2006 Sep;28(6):605-11
references.pmid: 16945211
references.citation: Lancet Neurol. 2007 Apr;6(4):373-8
references.pmid: 17362841
references.citation: J Neurochem. 2007 Jun;101(5):1172-84
references.pmid: 17286590
references.citation: Biochem Biophys Res Commun. 2004 May 21;318(1):187-91
references.pmid: 15110771
references.citation: Ann Hum Genet. 2005 Mar;69(Pt 2):227-32
references.pmid: 15720304
references.citation: J Cardiovasc Pharmacol. 1992;19 Suppl 6:S63-71
references.pmid: 1382167
references.citation: Expert Opin Biol Ther. 2008 Nov;8(11):1669-73
references.pmid: 18847303
references.citation: Curr Alzheimer Res. 2006 Feb;3(1):71-3
references.pmid: 16472206
references.citation: Nat Genet. 2007 Jan;39(1):17-23
references.pmid: 17192785
references.citation: Am J Hypertens. 1989 Apr;2(4):294-306
references.pmid: 2706094
references.citation: J Hypertens. 1996 Jun;14(6):719-27
references.pmid: 8793694
references.citation: J Neurosci. 2007 Aug 8;27(32):8628-35
references.pmid: 17687040
references.citation: J Clin Invest. 1990 Oct;86(4):1343-6
references.pmid: 1976655
references.citation: Rapid Commun Mass Spectrom. 2008;22(2):231-9
references.pmid: 18085519
references.citation: Am J Geriatr Psychiatry. 2008 Nov;16(11):883-92
references.pmid: 18978249
references.citation: Expert Opin Ther Targets. 2004 Feb;8(1):7-14
references.pmid: 14996614
references.citation: Am J Epidemiol. 2005 Aug 15;162(4):305-17
references.pmid: 16033878
references.citation: Neurogenetics. 2009 Feb;10(1):19-25
references.pmid: 18830724
references.citation: Eur J Pharmacol. 2008 Jun 24;588(1):18-25
references.pmid: 18495113
references.citation: J Alzheimers Dis. 2009;16(3):609-18
references.pmid: 19276555
references.citation: J Clin Invest. 2007 Nov;117(11):3393-402
references.pmid: 17965777
references.citation: Neurosci Lett. 2002 Aug 16;328(3):314-8
references.pmid: 12147333
references.citation: J Renin Angiotensin Aldosterone Syst. 2005 Dec;6(3):121-31
references.pmid: 16525942
references.citation: Brain Pathol. 2008 Apr;18(2):240-52
references.pmid: 18363935
references.citation: Am J Hum Genet. 2006 May;78(5):871-877
references.pmid: 16642441
references.citation: Neurochem Int. 2008 Nov;53(5):103-11
references.pmid: 18602955
references.citation: Neuropathol Appl Neurobiol. 2008 Apr;34(2):181-93
references.pmid: 17973905
references.citation: J Hypertens. 1999 Dec;17(12 Pt 2):1813-9
references.pmid: 10703873
references.citation: Brain Res. 1985 Mar 4;328(2):215-21
references.pmid: 2985183
references.citation: Alzheimer Dis Assoc Disord. 1993 Summer;7(2):105-11
references.pmid: 8347328
references.citation: Neurobiol Dis. 2007 Apr;26(1):27-35
references.pmid: 17270454
references.citation: Curr Alzheimer Res. 2005 Jan;2(1):29-35
references.pmid: 15977987
references.citation: Lancet Neurol. 2008 Aug;7(8):683-9
references.pmid: 18614402
references.citation: Cell Tissue Res. 2006 Nov;326(2):599-616
references.pmid: 16555051
references.citation: Neurogenetics. 2009 Feb;10(1):13-7
references.pmid: 18813964
references.citation: Arch Neurol. 2008 Jan;65(1):45-53
references.pmid: 17998437
references.citation: J Gerontol A Biol Sci Med Sci. 2005 Jan;60(1):67-73
references.pmid: 15741285
references.citation: J Renin Angiotensin Aldosterone Syst. 2003 Jun;4(2):80-93
references.pmid: 12806589
references.citation: Am J Transl Res. 2009 Jan 18;1(2):163-77
references.pmid: 19956428
references.citation: J Hum Hypertens. 2003 Nov;17(11):781-5
references.pmid: 14578918
references.citation: Am J Med Genet B Neuropsychiatr Genet. 2009 Jul 5;150B(5):721-35
references.pmid: 19105203
references.citation: Neurol Res. 2003 Sep;25(6):675-80
references.pmid: 14503023
references.citation: Geriatrics. 2005 Jan;60(1):20-2, 24
references.pmid: 15700945
references.citation: Eur J Clin Chem Clin Biochem. 1993 Aug;31(8):495-7
references.pmid: 8218581
references.citation: J Alzheimers Dis. 2008 Aug;14(4):453-7
references.pmid: 18688098