title: Oxidative DNA damage in patients with cataract.
abstract: OBJECTIVE
  This study examines the levels of oxidative damage in patients with cataract.
  
  
  METHODS
  Blood samples were collected from 60 patients with cataract and 60 age- and gender-matched healthy individuals to measure 8-hydroxy 2-deoxyguanosine (8-OHdG) and malondialdehyde (MDA) levels.
  
  
  RESULTS
  A significant difference was observed in leukocyte 8-OHdG levels in patients with cataract in comparison with healthy persons (p < 0.001). Similarly, a significant difference was observed in plasma MDA levels in patients with cataract in comparison with healthy persons (p<0.001). In addition, a significant correlation was found between levels of 8-OHdG in leukocyte DNA and plasma MDA (r = 0.859, p < 0.001).
  
  
  CONCLUSIONS
  This study measured the oxidative DNA damage by measuring the 8-OHdG in the leukocyte DNA in patients with cataract. In addition, the level of MDA - a marker for lipid peroxidation - was measured to determine lipid peroxidation.
authors.affiliation: Department of Ophthalmology, Ataturk University, Erzurum, Turkey. orhanates69@hotmail.com
authors.forename: Orhan
authors.initials: O
authors.lastname: Ates
authors.forename: Hakan Hamit
authors.initials: HH
authors.lastname: Alp
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Kocer
authors.forename: Orhan
authors.initials: O
authors.lastname: Baykal
authors.forename: Ilknur A
authors.initials: IA
authors.lastname: Salman
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000368:Aged; D000375:Aging / Q000502:physiology; D002386:Cataract / Q000097:blood / Q000235:genetics*; D002851:Chromatography, High Pressure Liquid; D004249:DNA Damage; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000097:blood; D005260:Female; D006801:Humans; D007962:Leukocytes / Q000378:metabolism; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D017382:Reactive Oxygen Species; D008315:Malondialdehyde; D000080242:8-Hydroxy-2'-Deoxyguanosine; D003849:Deoxyguanosine