[Roles of the interaction between beta2-AR polymorphism and occupational mental stress in EH].
OBJECTIVE
To explore the role of the interaction between beta2-adrenergic receptor (beta2-AR) gene Arg16Gly polymorphism and occupational mental stress in EH.


METHODS
Using 1:1 case-control study, we select 95 couple people as the study objects from the high-exposure occupational stress males who work on the train. Measuring occupational stress, stress reaction,anxiety, type A behavior and other occupational mental stress by using proper questionnaire, and applying PCR-RFLP technology to detect adrenergic receptor (beta2-AR) Arg16Gly Polymorphism. Using likelihood ratio test to judge whether it exist the interaction between the potencies and fits the multiplicative model: OR = OR11/(OR01 x OR10).


RESULTS
The distribution of Arg/Arg, Arg/Gly, Gly/Gly in essential hypertension cases and controls are significant difference (P < 0.05), Gly/Gly had a increased risk of hypertension 2.759 (95% CI: 1.200-6.347) compared to Arg/Arg upon controling BMI and other factors. The interaction among Arg16Gly(A/G + G/G) gene.occupational stress reaction and anxiety is fit the multiplicative model. The results showed that when Arg16Gly(A/G + G/G) genotype interact with strain, the risk of EH will add to 12.797 (95% CI: 3.379-48.461). When it interact with anxiety, the risk of EH will add to 40.862 (95% CI: 1.403-119.057).


CONCLUSIONS
Arg16Gly polymorphism of beta2-AR might be the crucial risk factor for EH among high-exposure occupational stress males. Individual who has genotype Gly/Gly, while exposure of strain and T-Anxiety is much easier to get EH.
Liu
Baoying
B
Public Health College of Fujian Medical University, Fujian 350004, China. liuby5@126.com
Zhou
Quan
Q
Zhong
Ping
P
Yang
Hua
H
D000328:Adult; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000235:genetics*; D008297:Male; D016273:Occupational Exposure; D011110:Polymorphism, Genetic; D015995:Prevalence; D011890:Railroads; D018343:Receptors, Adrenergic, beta-2 / Q000235:genetics*; D012307:Risk Factors; D013312:Stress, Physiological / Q000502:physiology*
C553443:ADRB2 protein, human; D018343:Receptors, Adrenergic, beta-2