Notch signalling: receptor cis-inhibition to achieve directionality.
Lateral inhibition, by which single cells become distinct from their neighbours, can be mediated by Notch signalling during animal development. Signalling directionality is presumably achieved by downregulation of the Notch ligand in signal-receiving cells. New evidence suggests that cis-inhibition of the receptor in the ligand-sending cell might also provide directionality.
del Alamo
David
D
Institut Pasteur, CNRS URA2578, 25 rue du Dr. Roux, 75724 Paris CEDEX 15, France. fschweis@pasteur.fr
Schweisguth
François
F
D000818:Animals; D002450:Cell Communication; D019070:Cell Lineage; D054910:Compound Eye, Arthropod / Q000166:cytology* / Q000254:growth & development; D029721:Drosophila Proteins / Q000502:physiology*; D004331:Drosophila melanogaster / Q000166:cytology / Q000254:growth & development; D004815:Epidermal Growth Factor / Q000502:physiology; D025461:Feedback, Physiological; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins / Q000502:physiology*; D008954:Models, Biological; D017956:Photoreceptor Cells, Invertebrate / Q000166:cytology* / Q000378:metabolism; D051880:Receptors, Notch / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
D029721:Drosophila Proteins; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; C497759:N protein, Drosophila; D051880:Receptors, Notch; C064045:delta protein; D004815:Epidermal Growth Factor