title: Tinnitus-provoking salicylate treatment triggers social impairments in mice.
abstract: OBJECTIVE
  Tinnitus (perception of sound in silence) strongly affects the quality of life of sufferers. Tinnitus sufferers and their relatives frequently complain about major social impairments. However, it is not known whether this impairment directly results from the occurrence of tinnitus or is the indirect expression of a preexisting psychological vulnerability. Using the well-characterized animal model of salicylate-induced tinnitus, we investigate in mice whether the occurrence of tinnitus can trigger social impairments.
  
  
  METHODS
  Experiments were performed on 32 male Balb/C mice. Tinnitus was induced in mice using salicylate treatment. Social behavior was assessed in experimental and control animals using social interaction paradigm. Interaction time, number of social events, and number of nonsocial events were assessed in all animals.
  
  
  RESULTS
  We demonstrate for the first time that treatment known to induce tinnitus triggers complex social impairments in mice. While salicylate-treated animals present a massive decrease in their overall social interactions compared to control untreated animals, they also display a paradoxal increase in the number of conspecific followings.
  
  
  CONCLUSIONS
  Tinnitus can thus trigger a complex set of modifications of behavior, which will not only find their expression at the individual level, but also at the social level. Our results suggest that tinnitus can directly be a cause of psychosocial impairment in human and have strong implications for the clinical management of tinnitus sufferers.
authors.affiliation: Centre de Recherche Université Laval Robert-Giffard (CRULRG), Laval University, Quebec City, QC, Canada G1K 7P4. matthieu.guitton@pha.ulaval.ca
authors.forename: Matthieu J
authors.initials: MJ
authors.lastname: Guitton
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000633:toxicity*; D004195:Disease Models, Animal; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D012919:Social Behavior; D012980:Sodium Salicylate / Q000633:toxicity*; D014012:Tinnitus / Q000139:chemically induced / Q000523:psychology*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D012980:Sodium Salicylate