title: Effect of N-acetylcysteine on (12)C(6+) ion irradiation-induced lymphocytes DNA damages and immunity changes in mice.
abstract: The aims of present study are to estimate the biological risks to the immunity of mice exposed to heavy ion radiation and to investigate the effect of N-acetylcysteine (NAC) on (12)C(6+) ion irradiation-induced lymphocyte DNA damage. Results showed that in the brine group, the levels of lymphocyte DNA damage and MN, thymocytes G(2)/M phase arrest and apoptosis percentages (except for activity of NK cells) were up at each time point. A time-response curve for MN and DNA damage appeared in the NAC group. We found that whole-body (12)C(6+) ion irradiation at a dose of 4 Gy could: induce lymphocyte DNA double-strand breaks (DSBs); immunocytes DSBs may lead to acute effects on immunity; and 200 mg/kg NAC showed significant protection against radiation harm.
authors.affiliation: Research Center for Heavy Ion Radiation Biology and Medicine, Institute of Modern Physics, Chinese Academy of Science, Lanzhou, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Xie
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.forename: Ji-Fang
authors.initials: JF
authors.lastname: Hao
authors.forename: Rong
authors.initials: R
authors.lastname: Qiu
mesh_terms: D000111:Acetylcysteine / Q000008:administration & dosage*; D000818:Animals; D002478:Cells, Cultured; D004249:DNA Damage / Q000528:radiation effects*; D004305:Dose-Response Relationship, Drug; D020450:Heavy Ions; D007113:Immunity, Innate / Q000187:drug effects* / Q000528:radiation effects*; D008214:Lymphocytes / Q000187:drug effects* / Q000276:immunology / Q000528:radiation effects*; D051379:Mice; D011829:Radiation Dosage; D011837:Radiation-Protective Agents / Q000008:administration & dosage; D014916:Whole-Body Irradiation
chemical_list: D011837:Radiation-Protective Agents; D000111:Acetylcysteine