title: Predictors of peritoneal carcinomatosis in patients with gastric cancer treated at a single institution in Brazil.
abstract: BACKGROUND
  Peritoneal carcinomatosis is a common pattern of recurrence in gastric cancer and is associated with a poor prognosis. Determining predictive factors for peritoneal recurrence can help the selection of patients suitable for more aggressive treatment strategies.
  
  
  METHODS
  A retrospective chart review of 162 patients diagnosed with gastric cancer with no peritoneal carcinomatosis and treated at a single institution in Brazil from January 1994 to December 2004 was carried out. Univariate and multivariate analyses were performed to identify patient and tumor-related characteristics associated with the development of peritoneal metastasis.
  
  
  RESULTS
  Twenty-three (14.2%) patients developed peritoneal carcinomatosis. Three independent factors associated with the development of peritoneal metastasis were identified by multivariate analysis: signet-ring cell histology (odds ratio [OR] = 4.9; P = 0.018), the presence of vascular invasion (OR = 4.8; P = 0.022), and the presence of visceral metastasis at diagnosis (OR = 5.1; P = 0.011). Tumor stages T3 or T4 showed a trend towards significance (P = 0.062).
  
  
  CONCLUSIONS
  Patients with gastric cancer presenting with signet-ring histology, vascular invasion, or visceral metastasis appear to be at higher risk for the development of peritoneal carcinomatosis.
authors.affiliation: Fundação Antônio Prudente, Hospital do Câncer A. C. Camargo, São Paulo, SP 01509-900, Brazil. marcello.fanelli@hcancer.org.br
authors.forename: Marcello F
authors.initials: MF
authors.lastname: Fanelli
authors.forename: Tadeu F
authors.initials: TF
authors.lastname: de Paiva
authors.forename: Milton J B
authors.initials: MJ
authors.lastname: Silva
authors.forename: Carlos F L
authors.initials: CF
authors.lastname: Benevides
authors.forename: Andréa P G
authors.initials: AP
authors.lastname: Guimarães
authors.forename: Daniel L
authors.initials: DL
authors.lastname: Gimenes
authors.forename: Edilson D
authors.initials: ED
authors.lastname: Pinheiro
authors.forename: José A
authors.initials: JA
authors.lastname: Rinck
authors.forename: Ulisses R
authors.initials: UR
authors.lastname: Nicolau
authors.forename: Solange M
authors.initials: SM
authors.lastname: Sanches
authors.forename: Celso A L
authors.initials: CA
authors.lastname: Mello
authors.forename: Aldo L A
authors.initials: AL
authors.lastname: Dettino
authors.forename: Marcelo R S
authors.initials: MR
authors.lastname: Cruz
authors.forename: Leila Maria M P
authors.initials: LM
authors.lastname: de Melo
authors.forename: Maria N C
authors.initials: MN
authors.lastname: Formiga
authors.forename: Vladmir C C
authors.initials: VC
authors.lastname: de Lima
authors.forename: Ludmilla T D
authors.initials: LT
authors.lastname: Chinen
mesh_terms: D000328:Adult; D018279:Carcinoma, Signet Ring Cell / Q000401:mortality / Q000473:pathology* / Q000556:secondary* / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D010534:Peritoneal Neoplasms / Q000401:mortality / Q000556:secondary*; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000401:mortality / Q000473:pathology* / Q000628:therapy