title: Caenorhabditis elegans BAH-1 is a DUF23 protein expressed in seam cells and required for microbial biofilm binding to the cuticle.
abstract: The cuticle of Caenorhabditis elegans, a complex, multi-layered extracellular matrix, is a major interface between the animal and its environment. Biofilms produced by the bacterial genus Yersinia attach to the cuticle of the worm, providing an assay for surface characteristics. A C. elegans gene required for biofilm attachment, bah-1, encodes a protein containing the domain of unknown function DUF23. The DUF23 domain is found in 61 predicted proteins in C. elegans, which can be divided into three distinct phylogenetic clades. bah-1 is expressed in seam cells, which are among the hypodermal cells that synthesize the cuticle, and is regulated by a TGF-beta signaling pathway.
authors.affiliation: Department of Cell and Tissue Biology, Program in Microbial Pathogenesis and Host Defense, University of California San Francisco, San Francisco, California, USA. drace_km@mercer.edu
authors.forename: Kevin
authors.initials: K
authors.lastname: Drace
authors.forename: Stephanie
authors.initials: S
authors.lastname: McLaughlin
authors.forename: Creg
authors.initials: C
authors.lastname: Darby
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D018441:Biofilms; D017173:Caenorhabditis elegans / Q000235:genetics / Q000378:metabolism*; D029742:Caenorhabditis elegans Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D017931:DNA Primers; D005455:Fluorescent Antibody Technique; D008969:Molecular Sequence Data; D010802:Phylogeny; D034622:RNA Interference; D020133:Reverse Transcriptase Polymerase Chain Reaction; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction; D016212:Transforming Growth Factor beta / Q000378:metabolism
chemical_list: D029742:Caenorhabditis elegans Proteins; D017931:DNA Primers; D016212:Transforming Growth Factor beta
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