Infliximab for the treatment of plaque psoriasis.
Infliximab is a monoclonal antibody that targets tumor necrosis factor-alpha (TNFalpha). It is used in the treatment of a number of inflammatory disorders including severe plaque psoriasis. TNFalpha is thought to have a major role in psoriasis by promoting an inflammatory infiltrate into the skin and inducing keratinocyte proliferation and preventing keratinocyte apoptosis, which directly contributes to the characteristic plaque skin lesions. Based on four randomized, placebo-controlled, double-blind clinical trials and nine open-label uncontrolled trials of the use of infliximab in plaque psoriasis, it was found that infliximab is a highly efficacious, rapid, sustainable, and relatively safe therapy. Yet as with any biologic, caution is recommended in its use as infusion reactions, lupus-like syndromes, infections, malignancies including lymphomas, as well as other rare events have been reported.
Gall
Jennifer S
JS
State University of New York at Buffalo, School of Medicine and Biomedical Sciences, Department of Dermatology, NY, USA.
Kalb
Robert E
RE
Arthritis Rheum. 2006 Jul;54(7):2039-46
16802339
Arch Dermatol. 2001 Nov;137(11):1447-54
11708947
Int J Cardiol. 2002 Dec;86(2-3):123-30
12419548
Clin Immunol. 2007 May;123(2):129-38
17317321
J Drugs Dermatol. 2007 Feb;6(2):207-10
17373180
N Engl J Med. 2001 Oct 11;345(15):1098-104
11596589
Arthritis Rheum. 2001 Sep;44(9):1977-83
11592357
Br J Dermatol. 2006 Mar;154(3):460-6
16445776
Arch Dermatol. 2001 Mar;137(3):280-4
11255325
J Am Acad Dermatol. 2003 Aug;49(2 Suppl):S112-7
12894134
Ann Intern Med. 2003 May 20;138(10):807-11
12755552
J Am Acad Dermatol. 2005 Jan;52(1):23-6
15627076
J Clin Invest. 2004 Jun;113(12):1664-75
15199399
J Cutan Med Surg. 2004 Jul-Aug;8(4):205-12
16091996
Int J Immunopathol Pharmacol. 2004 Sep-Dec;17(3):373-80
15461871
Semin Cutan Med Surg. 2007 Mar;26(1):6-14
17349557
Arch Dermatol. 1991 Jun;127(6):871-84
2036036
J Am Acad Dermatol. 2002 Jun;46(6):886-91
12063486
Arthritis Rheum. 2001 Dec;44(12):2862-9
11762947
J Am Acad Dermatol. 2005 Oct;53(4):616-22
16198781
Medicine (Baltimore). 2007 Jul;86(4):242-251
17632266
Australas J Dermatol. 2003 May;44(2):116-20
12752184
J Drugs Dermatol. 2006 Mar;5(3):251-4
16573258
Gut. 2002 Feb;50(2):206-11
11788561
Clin Exp Rheumatol. 2006 Sep-Oct;24(5):587-93
17181932
Semin Arthritis Rheum. 2008 Jun;37(6):381-7
17977585
Science. 2002 Apr 12;296(5566):301-5
11951032
J Cutan Med Surg. 2007 May-Jun;11(3):99-122
17511926
J Am Acad Dermatol. 2003 Jan;48(1):68-75
12522373
JAMA. 2006 May 17;295(19):2275-85
16705109
J Am Coll Cardiol. 2000 Mar 1;35(3):537-44
10716453
J Am Acad Dermatol. 2007 Jan;56(1):31.e1-15
17097378
J Invest Dermatol. 1990 Aug;95(2):229-32
2380581
Arthritis Rheum. 2002 Dec;46(12):3151-8
12483718
Arthritis Rheum. 2006 Sep;54(9):2757-64
16947774
Br J Dermatol. 2005 May;152(5):954-60
15888152
Arthritis Rheum. 2003 Nov;48(11):3013-22
14613261
Lancet. 2005 Oct 15-21;366(9494):1367-74
16226614
Clin Ther. 2002 Nov;24(11):1720-40; discussion 1719
12501870
Circulation. 2003 Jul 1;107(25):3133-40
12796126
Drug Saf. 2006;29(1):49-66
16454534
Br J Dermatol. 2006 Jul;155(1):160-9
16792769
Circulation. 1996 Feb 15;93(4):704-11
8640999
J Am Acad Dermatol. 2006 Jun;54(6):1003-12
16713454
Curr Treat Options Gastroenterol. 2007 Jun;10(3):171-7
17547855
Lancet Infect Dis. 2003 Mar;3(3):148-55
12614731
J Am Acad Dermatol. 1999 Sep;41(3 Pt 1):401-7
10459113
Dig Dis Sci. 2007 Jun;52(6):1481-4
17429728
J Drugs Dermatol. 2004 May-Jun;3(3):305-8
15176166
Clin Exp Dermatol. 2006 Sep;31(5):630-3
16901301
J Am Acad Dermatol. 2003 Jun;48(6):829-35
12789171
Br J Dermatol. 2007 Feb;156(2):329-36
17223874
Arthritis Rheum. 2007 Sep;56(9):2886-95
17729297
J Am Acad Dermatol. 2004 Oct;51(4):534-42
15389187
Drugs. 2000 Jun;59(6):1341-59
10882166
Lancet. 2001 Jun 9;357(9271):1842-7
11410193
Clin Exp Dermatol. 2006 May;31(3):460-1
16681606
Lancet. 2003 Apr 5;361(9364):1197-204
12686053
J Am Acad Dermatol. 2007 Jul;57(1):120-5
17482715
J Biol Chem. 2004 Jul 30;279(31):32633-42
15145954
Ann Rheum Dis. 2004 Jul;63(7):769-73
15194570