title: Behavioral and neural correlates of memory selection and interference resolution during a digit working memory task.
abstract: Neuroimaging studies have shown the involvement of prefrontal and posterior parietal cortexes in regulating information processing. We conducted behavioral and fMRI experiments to investigate the relationship between memory selection and proactive interference (PI), using a delayed recognition task with a selection cue presented during the delay indicating which two of the four studied digits were relevant to the present test. PI was indexed by the response time differences between rejecting probes matching and not matching the no longer relevant digits. By varying the delay intervals, we found that the effect of PI did not diminish, even for cases in which the postcue interval was extended to 9 sec, but was stronger when the precue interval was lengthened to 5 sec. By examining the correlation between PI index and neural correlates of memory selection, we found that stronger PI is predicted by lower selection-related activity in the left inferior parietal lobe, the precuneus, and the dorsal middle frontal gyrus. Our results suggest that activity in the prefrontal-parietal network may contribute to one's ability to focus on the task-relevant information and may proactively reduce PI in working memory.
authors.affiliation: Department of Psychology, Stony Brook University, Stony Brook, New York, USA.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Yi
authors.forename: Naomi
authors.initials: N
authors.lastname: Driesen
authors.forename: Hoi-Chung
authors.initials: HC
authors.lastname: Leung
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping; D003463:Cues; D005260:Female; D006801:Humans; D016014:Linear Models; D008279:Magnetic Resonance Imaging; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology*; D009483:Neuropsychological Tests; D011930:Reaction Time; D021641:Recognition, Psychology; D013997:Time Factors; D055815:Young Adult
references.citation: Nat Neurosci. 2002 Oct;5(10):995-1002
references.pmid: 12219097
references.citation: Annu Rev Neurosci. 1995;18:193-222
references.pmid: 7605061
references.citation: Nat Neurosci. 2000 Mar;3(3):284-91
references.pmid: 10700262
references.citation: Neuroimage. 2003 Nov;20(3):1531-9
references.pmid: 14642465
references.citation: Neuroimage. 2004 Nov;23(3):1013-9
references.pmid: 15528101
references.citation: Cortex. 2003 Sep-Dec;39(4-5):667-86
references.pmid: 14584548
references.citation: Proc Natl Acad Sci U S A. 1999 Jun 22;96(13):7514-9
references.pmid: 10377446
references.citation: Neuron. 2005 Nov 23;48(4):687-97
references.pmid: 16301183
references.citation: Annu Rev Neurosci. 2001;24:167-202
references.pmid: 11283309
references.citation: Cereb Cortex. 2003 Dec;13(12):1334-43
references.pmid: 14615298
references.citation: Neuroimage. 2009 Apr 15;45(3):963-75
references.pmid: 19280708
references.citation: Nat Rev Neurosci. 2000 Oct;1(1):59-65
references.pmid: 11252769
references.citation: Psychol Rev. 1957 Jan;64(1):49-60
references.pmid: 13408394
references.citation: Acta Psychol (Amst). 1999 Apr;101(2-3):159-78
references.pmid: 10344184
references.citation: Cogn Affect Behav Neurosci. 2002 Jun;2(2):109-20
references.pmid: 12455679
references.citation: J Exp Psychol Learn Mem Cogn. 2005 Jul;31(4):714-28
references.pmid: 16060775
references.citation: Neuroimage. 1999 Dec;10(6):695-704
references.pmid: 10600415
references.citation: Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):8410-3
references.pmid: 9653200
references.citation: Nat Rev Neurosci. 2002 Mar;3(3):201-15
references.pmid: 11994752
references.citation: J Cogn Neurosci. 2010 Feb;22(2):292-306
references.pmid: 19400681
references.citation: Neuron. 1998 Oct;21(4):761-73
references.pmid: 9808463
references.citation: J Cogn Neurosci. 2003 Nov 15;15(8):1176-94
references.pmid: 14709235
references.citation: J Exp Psychol Learn Mem Cogn. 2001 Jul;27(4):948-57
references.pmid: 11486928
references.citation: Trends Cogn Sci. 2006 Jan;10(1):38-45
references.pmid: 16318922
references.citation: Cogn Affect Behav Neurosci. 2001 Mar;1(1):10-21
references.pmid: 12467100
references.citation: J Exp Psychol Learn Mem Cogn. 2002 May;28(3):411-21
references.pmid: 12018494
references.citation: Neuroimage. 2007 Jun;36(2):441-53
references.pmid: 17462914
references.citation: Psychol Bull. 1988 Sep;104(2):163-91
references.pmid: 3054993
references.citation: Proc Natl Acad Sci U S A. 2006 Dec 19;103(51):19530-4
references.pmid: 17151200
references.citation: Neuroimage. 2004 Oct;23(2):596-603
references.pmid: 15488409
references.citation: Cereb Cortex. 2004 Dec;14(12):1346-57
references.pmid: 15166105
references.citation: Behav Brain Sci. 2001 Feb;24(1):87-114; discussion 114-85
references.pmid: 11515286
references.citation: Neuroimage. 2007 Dec;38(4):740-51
references.pmid: 17904389
references.citation: Neuroscience. 2006 Apr 28;139(1):23-38
references.pmid: 16324795
references.citation: Neuroimage. 2005 Jul 1;26(3):733-43
references.pmid: 15955482
references.citation: Cereb Cortex. 2007 Sep;17(9):2072-83
references.pmid: 17099066
references.citation: Prog Neurobiol. 2005 Jul;76(4):236-56
references.pmid: 16257103
references.citation: Trends Cogn Sci. 2001 Mar 1;5(3):119-126
references.pmid: 11239812
references.citation: Brain Res Cogn Brain Res. 2003 Dec;18(1):26-38
references.pmid: 14659494
references.citation: Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12959-64
references.pmid: 10536030
references.citation: Neuroscience. 2006 Apr 28;139(1):181-93
references.pmid: 16337090
references.citation: J Cogn Neurosci. 2004 Apr;16(3):363-73
references.pmid: 15072672
references.citation: Annu Rev Psychol. 2008;59:193-224
references.pmid: 17854286