Regulatory T cells that become autoaggressive.
Foxp3 expression is not stable and may be extinguished both in vitro and in vivo in regulatory T cells that convert into proinflammatory effector T cells. The loss of Foxp3 in regulatory T cells under autoimmune conditions may result in the conversion of suppressor T cells into highly autoaggressive lymphocytes.
Hawiger
Daniel
D
Flavell
Richard A
RA
D000818:Animals; D015551:Autoimmunity; D051858:Forkhead Transcription Factors / Q000502:physiology*; D019426:Integrases / Q000502:physiology; D051379:Mice; D011948:Receptors, Antigen, T-Cell / Q000502:physiology; D050378:T-Lymphocytes, Regulatory / Q000502:physiology*
D051858:Forkhead Transcription Factors; C498833:Foxp3 protein, mouse; D011948:Receptors, Antigen, T-Cell; C045073:Cre recombinase; D019426:Integrases
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