Constituents from fruits of Cupressus sempervirens.
Two new phenolic glycosides (1, 2), along with fourteen known compounds (3-16) have been isolated from the fruit of Cupressus sempervirens. The structures of these compounds were determined by spectroscopic analysis and were evaluated for their inhibitory activity against glycogen phosphorylase and glucose-6-phosphatase enzymes. Compounds 14 showed a moderate inhibition against glucose-6-phosphatase and 15 against glycogen phosphorylase enzymes.
Rawat
Preeti
P
Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow, India.
Khan
Mohammad F
MF
Kumar
Manmeet
M
Tamarkar
Akhilesh K
AK
Srivastava
Arvind K
AK
Arya
Kamal R
KR
Maurya
Rakesh
R
D045784:Abietanes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D029781:Cupressus / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D005638:Fruit; D005952:Glucose-6-Phosphatase / Q000037:antagonists & inhibitors*; D024981:Glycogen Phosphorylase / Q000037:antagonists & inhibitors*; D006027:Glycosides / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D010636:Phenols / Q000302:isolation & purification / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology; D018515:Plant Leaves
C551159:15-acetoxyimbricatolic acid; D045784:Abietanes; D004224:Diterpenes; D004791:Enzyme Inhibitors; D006027:Glycosides; D010636:Phenols; D010936:Plant Extracts; C431074:ferruginol; D024981:Glycogen Phosphorylase; D005952:Glucose-6-Phosphatase