title: Tumor-to-tumor metastases to follicular variant of papillary thyroid carcinoma: histologic, immunohistochemical, and molecular studies of two unusual cases.
abstract: Tumor-to-tumor metastasis in thyroid neoplasms is exceedingly uncommon. Two unusual cases of breast carcinoma and renal cell carcinoma metastatic to follicular variant papillary carcinoma are reported. On histologic sections, the donor tumor cells infiltrated the substance of the recipient tumor and the angiolymphatic channels, but the bulk of metastatic tumor was confined within the thyroid carcinoma. Immunohistochemical stains as well as molecular studies confirmed the origin of both donor tumors, as well as the diagnosis of follicular variant of papillary carcinoma in the recipient tumors. Distinguishing between two such tumor populations may be difficult when the donor tumor cells morphologically resemble primary neoplasms of the recipient organ. A history of previous malignancy and ancillary studies can be helpful in making this distinction and rendering the correct diagnosis. A brief review of literature and discussion of tumor-to-tumor metastasis in thyroid neoplasms is also presented.
authors.affiliation: Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.
authors.forename: Jing
authors.initials: J
authors.lastname: Yu
authors.forename: Marina N
authors.initials: MN
authors.lastname: Nikiforova
authors.forename: Steven P
authors.initials: SP
authors.lastname: Hodak
authors.forename: John H
authors.initials: JH
authors.lastname: Yim
authors.forename: Guoping
authors.initials: G
authors.lastname: Cai
authors.forename: Andrew
authors.initials: A
authors.lastname: Walls
authors.forename: Yuri E
authors.initials: YE
authors.lastname: Nikiforov
authors.forename: Raja R
authors.initials: RR
authors.lastname: Seethala
mesh_terms: D051017:Apoptosis Regulatory Proteins; D015415:Biomarkers / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis; D001943:Breast Neoplasms / Q000473:pathology; D018275:Carcinoma, Lobular / Q000473:pathology / Q000556:secondary; D018265:Carcinoma, Papillary, Follicular / Q000473:pathology*; D002292:Carcinoma, Renal Cell / Q000473:pathology / Q000556:secondary; D004268:DNA-Binding Proteins / Q000032:analysis; D005260:Female; D037502:Galectin 3 / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis; D007680:Kidney Neoplasms / Q000473:pathology; D019656:Loss of Heterozygosity; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics; D008875:Middle Aged; D009362:Neoplasm Metastasis / Q000473:pathology*; D016609:Neoplasms, Second Primary / Q000473:pathology*; D015260:Neprilysin / Q000032:analysis; D009687:Nuclear Proteins / Q000032:analysis; D013954:Thyroglobulin / Q000032:analysis; D013964:Thyroid Neoplasms / Q000473:pathology* / Q000556:secondary*; D015534:Trans-Activators; D014157:Transcription Factors / Q000032:analysis; D014746:Vimentin / Q000032:analysis; D000951:Antigens, Neoplasm
chemical_list: D051017:Apoptosis Regulatory Proteins; D015415:Biomarkers; D014408:Biomarkers, Tumor; D004268:DNA-Binding Proteins; D037502:Galectin 3; D007633:Keratins; D015260:Neprilysin; D009687:Nuclear Proteins; D013954:Thyroglobulin; D015534:Trans-Activators; D014157:Transcription Factors; D014746:Vimentin; C400901:CAM 5.2 antigen; C512688:CITED1 protein, human; C432845:HBME-1 antigen; D000951:Antigens, Neoplasm; C504003:TTF1 protein, human
references.citation: Guys Hosp Rep. 1958;107(1):60-5
references.pmid: 13524722
references.citation: Acta Cytol. 1987 Nov-Dec;31(6):705-12
references.pmid: 3425131
references.citation: Am J Surg Pathol. 2006 Feb;30(2):216-22
references.pmid: 16434896
references.citation: Ann Diagn Pathol. 2004 Oct;8(5):305-8
references.pmid: 15494939
references.citation: J Endocrinol Invest. 2004 Nov;27(10):967-8
references.pmid: 15762048
references.citation: Diagn Cytopathol. 2009 Sep;37(9):665-6
references.pmid: 19191290
references.citation: Del Med J. 2003 Aug;75(8):285-8
references.pmid: 12971227
references.citation: J Clin Endocrinol Metab. 2006 Sep;91(9):3603-10
references.pmid: 16772343
references.citation: Histopathology. 2005 May;46(5):587-8
references.pmid: 15842643
references.citation: Mod Pathol. 2005 Nov;18(11):1424-31
references.pmid: 15920537
references.citation: Int J Surg Pathol. 2003 Apr;11(2):127-35
references.pmid: 12754635
references.citation: Pathol Res Pract. 2003;199(2):101-6
references.pmid: 12747472
references.citation: J Clin Endocrinol Metab. 2003 May;88(5):2318-26
references.pmid: 12727991
references.citation: Acta Pathol Microbiol Scand. 1968;73(4):481-8
references.pmid: 5697606
references.citation: Pathol Res Pract. 2000;196(5):333-6; discussion 337-8
references.pmid: 10834391
references.citation: Pathol Int. 2005 Sep;55(9):574-9
references.pmid: 16143033
references.citation: Cancer. 1968 Sep;22(3):635-43
references.pmid: 5673241
references.citation: Arch Pathol Lab Med. 1994 May;118(5):551-6
references.pmid: 7514864
references.citation: Am J Surg Pathol. 2001 Dec;25(12):1485-92
references.pmid: 11717537
references.citation: Acta Pathol Jpn. 1990 Aug;40(8):602-8
references.pmid: 2239314
references.citation: Arch Pathol Lab Med. 2002 Oct;126(10):1233-6
references.pmid: 12296767
references.citation: Urology. 1987 Jul;30(1):35-8
references.pmid: 3603907
references.citation: Arch Pathol Lab Med. 1999 Aug;123(8):703-6
references.pmid: 10420227
references.citation: Kyobu Geka. 1994 Apr;47(4):319-21
references.pmid: 8152182