Atlasin GTPases shape up ER networks.
The endoplasmic reticulum (ER) adopts a remarkable array of flattened membrane structures and branched tubular networks to support cellular function. Recent studies reveal that the integral membrane atlastin GTPases, which are linked to neurodegenerative diseases, catalyze membrane fusion and are required for the formation of branched membrane networks characteristic of the ER.
Barlowe
Charles
C
Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755, USA. barlowe@dartmouth.edu
D000818:Animals; D004268:DNA-Binding Proteins / Q000378:metabolism; D029721:Drosophila Proteins / Q000378:metabolism*; D004721:Endoplasmic Reticulum / Q000378:metabolism / Q000648:ultrastructure; D020558:GTP Phosphohydrolases / Q000378:metabolism*; D006801:Humans; D008561:Membrane Fusion / Q000502:physiology
D004268:DNA-Binding Proteins; C491076:Dp1 protein, Drosophila; D029721:Drosophila Proteins; D020558:GTP Phosphohydrolases; C543694:atl protein, Drosophila