title: Clinical inertia in depression treatment.
abstract: OBJECTIVE
  To explore reasons for clinical inertia in the management of persistent depression symptoms.
  
  
  METHODS
  We characterized patterns of treatment adjustment in primary care and their relation to the patient's clinical condition by modeling transition to a given treatment "state" conditional on the current state of treatment. We assessed associations of patient, clinician, and practice barriers with adjustment decisions.
  
  
  METHODS
  Survey data on patients in active care for major depression were collected at 6-month intervals over a 2-year period for the quality improvement for depression (QID) studies.
  
  
  METHODS
  Patient and clinician characteristics were collected at baseline. Depression severity and treatment were measured at each interval.
  
  
  RESULTS
  Approximately, one-third of the observation periods ending with less than a full response resulted in an adjustment recommendation. Clinicians often respond correctly to the combination of severe depression symptoms and less than maximal treatment by changing the treatment. Appropriate adjustment is less common, however, in management of less severely depressed patients who do not improve after starting treatment, particularly if their care already meets minimal treatment intensity guidelines.
  
  
  CONCLUSIONS
  Our findings suggest that quality improvement efforts should focus on promoting appropriate adjustments for patients with persistent depression symptoms, particularly those with less severe depression.
authors.affiliation: Thomson Reuters Healthcare, Cambridge, MA 02140, USA. rachel.henke@thomsonreuters.com
authors.forename: Rachel M
authors.initials: RM
authors.lastname: Henke
authors.forename: Alan M
authors.initials: AM
authors.lastname: Zaslavsky
authors.forename: Thomas G
authors.initials: TG
authors.lastname: McGuire
authors.forename: John Z
authors.initials: JZ
authors.lastname: Ayanian
authors.forename: Lisa V
authors.initials: LV
authors.lastname: Rubenstein
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015897:Comorbidity; D003863:Depression / Q000188:drug therapy / Q000628:therapy*; D019317:Evidence-Based Medicine; D005260:Female; D019538:Health Care Surveys; D006801:Humans; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D010818:Practice Patterns, Physicians' / Q000592:standards*; D012720:Severity of Illness Index; D016896:Treatment Outcome; D055815:Young Adult
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