title: Microencapsulation of isoniazid in genipin-crosslinked gelatin-A-κ-carrageenan polyelectrolyte complex.
abstract: BACKGROUND
  Microspheres of gelatin-A and κ-carrageenan were prepared by using genipin, a naturally occurring crosslinker, and sunflower oil as reaction media.
  
  
  METHODS
  The variations in the size of the microspheres formed by varying the amount of surfactant (0.33-1.0 g/g of polymer), polymer (1.5-3.0 g), and crosslinker (0.2-0.8 mmol) were studied by scanning electron microscopy. The encapsulation of isoniazid was carried out by absorption. The isoniazid content in the prepared microspheres was determined. The release characteristic of isoniazid was also studied at pH values 1.2 and 7.4 by using UV-spectrophotometer.
  
  
  RESULTS
  Characterization of the isoniazid-loaded microspheres was carried out by using Fourier transform infrared spectrophotometry, differential scanning calorimetry, and X-ray diffractometery.
authors.affiliation: Department of Chemical Sciences, Tezpur University, Napaam, Assam, India.
authors.forename: Nirmala
authors.initials: N
authors.lastname: Devi
authors.forename: Tarun K
authors.initials: TK
authors.lastname: Maji
mesh_terms: D000995:Antitubercular Agents / Q000008:administration & dosage; D002152:Calorimetry, Differential Scanning; D002351:Carrageenan / Q000737:chemistry*; D003432:Cross-Linking Reagents / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry; D004573:Electrolytes / Q000737:chemistry; D005780:Gelatin / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D039823:Iridoids / Q000737:chemistry*; D007538:Isoniazid / Q000008:administration & dosage*; D008863:Microspheres; D010316:Particle Size; D010938:Plant Oils / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D000074242:Sunflower Oil; D013501:Surface-Active Agents / Q000737:chemistry; D014961:X-Ray Diffraction
chemical_list: D000995:Antitubercular Agents; D003432:Cross-Linking Reagents; D004337:Drug Carriers; D004573:Electrolytes; D039823:Iridoids; D010938:Plant Oils; D000074242:Sunflower Oil; D013501:Surface-Active Agents; D002351:Carrageenan; D005780:Gelatin; C007834:genipin; D007538:Isoniazid