title: Abdominal visceral fat accumulation is associated with hippocampus volume in non-dementia patients with type 2 diabetes mellitus.
abstract: Obesity is associated with cognitive dysfunction, for which changes in the hippocampus plausibly play a pivotal role. We tested the hypothesis that an elevated level of visceral fat accumulation (VFA) correlates with hippocampus volume and insulin resistance in non-dementia patients with type 2 diabetes. Subjects included 48 non-dementia patients with type 2 diabetes, who were divided into two groups, high VFA group (mean+/-standard deviation: age=65+/-6 years, n=30) and normal VFA group (65+/-5 years, n=18). Hippocampus volume has been quantitated with computer-assisted analysis using a magnetic resonance imaging (MRI) voxel-based specific regional analysis system developed for the study of Alzheimer's disease (VSRAD), which yields a Z-score as the end point for assessment of hippocampal volume. The Z-score was higher in the high VFA group than in the normal VFA group (p<0.0001). The fasting plasma glucose (p<0.05) and insulin concentrations (p<0.0001) and the homeostasis model assessment (HOMA) index (p<0.0001) were higher in the high VFA group than in the normal VFA group. Multiple regression analysis showed that VFA levels were independently predicted by Z-score and HOMA index. Our results indicate that the elevated level of VFA in Japanese non-dementia patients with type 2 diabetes is characterized by increased hippocampus volume and insulin resistance, and that the Z-score and HOMA index are independent predictors of VFA.
authors.affiliation: Department of Cardiology, Oita Red Cross Hospital, 3-2-37 Chiyomachi, Oita, Japan. anan-f@med.oita-u.ac.jp
authors.forename: Futoshi
authors.initials: F
authors.lastname: Anan
authors.forename: Takayuki
authors.initials: T
authors.lastname: Masaki
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Shimomura
authors.forename: Minoru
authors.initials: M
authors.lastname: Fujiki
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Umeno
authors.forename: Nobuoki
authors.initials: N
authors.lastname: Eshima
authors.forename: Tetsunori
authors.initials: T
authors.lastname: Saikawa
authors.forename: Hironobu
authors.initials: H
authors.lastname: Yoshimatsu
mesh_terms: D050153:Abdominal Fat / Q000473:pathology*; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D001921:Brain / Q000473:pathology; D003071:Cognition / Q000502:physiology; D003704:Dementia / Q000473:pathology / Q000523:psychology; D003924:Diabetes Mellitus, Type 2 / Q000473:pathology* / Q000523:psychology; D005260:Female; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D006973:Hypertension / Q000473:pathology / Q000503:physiopathology; D007091:Image Processing, Computer-Assisted; D050356:Lipid Metabolism / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D012044:Regression Analysis
chemical_list: D001786:Blood Glucose