IGF-1: elixir for motor neuron diseases.
Modulation of testosterone levels is a therapeutic approach for spinal and bulbar muscular atrophy (SBMA), a polyglutamine disorder that affects the motor neurons. The article by Palazzolo et al. in this issue of Neuron provides compelling evidence that the expression of insulin growth hormone is a potential therapeutic for SBMA.
Papanikolaou
Theodora
T
The Buck Institute for Age Research, Novato, CA 94945, USA.
Ellerby
Lisa M
LM
D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000235:genetics / Q000378:metabolism*; D016472:Motor Neuron Disease / Q000235:genetics / Q000378:metabolism* / Q000473:pathology / Q000628:therapy*; D018482:Muscle, Skeletal / Q000378:metabolism
D007334:Insulin-Like Growth Factor I