New nitrogen-containing sesquiterpenoids from the Taiwanese soft coral Cespitularia taeniata May.
Chemical investigation of the EtOH extract of the soft coral Cespitularia taeniata May collected in Taiwan has resulted in the isolation of two new sesquiterpene lactams, taenialactams A and B (1 and 2, resp.), and a new sesquiterpene lactone, taenialactone A (3), together with 8beta-methoxyatractylenolide (4) and atractylenolactam (5). The structures of these compounds were determined on the basis of spectroscopic analyses. The in vitro cytotoxic activities of the isolated metabolites were tested against KB, Daoy, and WiDr cell lines. A biogenetic pathway for these novel compounds was proposed.
Cheng
Yuan-Bin
YB
School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC.
Chen
Ching-Yeu
CY
Kuo
Yao-Haur
YH
Shen
Ya-Ching
YC
D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D018922:HL-60 Cells; D006801:Humans; D007624:KB Cells; D019906:Nuclear Magnetic Resonance, Biomolecular; D012717:Sesquiterpenes / Q000737:chemistry / Q000494:pharmacology*
D000970:Antineoplastic Agents; D012717:Sesquiterpenes