What's new about osmotic regulation of glycerophosphocholine.
Glycerophosphocholine is an abundant renal medullary organic osmolyte that protects renal medullary cells from the high interstitial concentrations of NaCl and urea to which they are normally exposed. We consider the metabolism of glycerophosphocholine, its osmotic regulation, and the recently discovered molecular identity of the enzymes that osmoregulate its abundance.
Gallazzini
Morgan
M
Department of Health and Human Services, Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
Burg
Maurice B
MB
D000818:Animals; D005997:Glycerylphosphorylcholine / Q000502:physiology*; D006801:Humans; D007679:Kidney Medulla / Q000166:cytology / Q000502:physiology*; D012965:Sodium Chloride / Q000378:metabolism; D014508:Urea / Q000378:metabolism; D014882:Water-Electrolyte Balance / Q000502:physiology*
D012965:Sodium Chloride; D005997:Glycerylphosphorylcholine; D014508:Urea
Am J Physiol. 1995 Jul;269(1 Pt 1):C35-41
7631758
Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):11026-31
18667693
Biochim Biophys Acta. 1993 Jul 25;1150(1):25-34
8392869
Am J Physiol. 1989 Dec;257(6 Pt 2):F1108-16
2603957
Biochem J. 1969 Oct;114(4):711-7
4310054
Pflugers Arch Gesamte Physiol Menschen Tiere. 1956;262(6):551-61
13359098
Biochem J. 1999 Dec 15;344 Pt 3:625-31
10585848
Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15260-5
17015841
Physiol Rev. 1991 Oct;71(4):1081-115
1924548
J Biol Chem. 1986 May 5;261(13):5872-7
3700377
Am J Physiol. 1989 Oct;257(4 Pt 1):C795-801
2801928
Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):13997-4002
16968772
Proc Natl Acad Sci U S A. 1991 Sep 1;88(17):7820-4
1652765
Am J Physiol. 1995 Feb;268(2 Pt 1):C402-12
7864079
Am J Physiol. 1998 Apr;274(4):F762-5
9575901
Physiol Rev. 2007 Oct;87(4):1441-74
17928589
Am J Physiol. 1983 Nov;245(5 Pt 1):C439-44
6638169
J Biol Chem. 2008 Mar 21;283(12):7309-13
18256030
J Mol Biol. 2003 Jul 18;330(4):851-66
12850152
J Biol Chem. 2003 Mar 7;278(10):8820-5
12514188
Science. 1982 Sep 24;217(4566):1214-22
7112124
Kidney Int Suppl. 1996 Dec;57:S100-4
8941929
Int J Biochem Cell Biol. 1995 Oct;27(10):1055-63
7496995
Biophys J. 1985 Mar;47(3):411-4
3978211
J Biol Chem. 2004 Jun 4;279(23):24024-33
15044461
J Neurosci. 2005 Mar 16;25(11):2865-73
15772346