title: Solid-pseudopapillary neoplasm of the pancreas with massive central calcification in an old man.
abstract: Solid-pseudopapillary neoplasm (SPN) is a rare pancreatic tumor primarily affecting women in their twenties. It is characterized by a well-demarcated or encapsulated mass, indolent behavior and favorable prognosis. Capsular or punctate calcification is occasionally observed. Reported herein is a case of SPN of the pancreas with massive calcification in a 76-year-old Japanese man. Macroscopically, the pancreatic tumor appeared to be a simple calcified nodule, but histological examination revealed that it was an epithelioid tumor with massive calcification. The tumor cells, forming nests and cords, had eosinophilic cytoplasm and small eccentric nuclei. They were immunohistochemically positive for vimentin, CD56 and neuron-specific enolase. Nuclear accumulation of beta-catenin protein and a point mutation of the beta-catenin gene by genomic DNA sequencing confirmed that the tumor was SPN. This is a very rare case of pancreatic SPN with massive calcification in an old man.
authors.affiliation: Department of Surgical Pathology, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan.
authors.forename: Ikuo
authors.initials: I
authors.lastname: Matsuda
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Hao
authors.forename: Masataka
authors.initials: M
authors.lastname: Zozumi
authors.forename: Kenji
authors.initials: K
authors.lastname: Koishi
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Matsumoto
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Kaibe
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Fujiwara
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Sasako
authors.forename: Seiichi
authors.initials: S
authors.lastname: Hirota
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology; D000368:Aged; D001483:Base Sequence; D002114:Calcinosis / Q000473:pathology*; D002291:Carcinoma, Papillary / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D010190:Pancreatic Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D017354:Point Mutation; D013274:Stomach Neoplasms / Q000473:pathology; D051176:beta Catenin / Q000235:genetics
chemical_list: D051176:beta Catenin