Reverse genetics technology for Rift Valley fever virus: current and future applications for the development of therapeutics and vaccines.
The advent of reverse genetics technology has revolutionized the study of RNA viruses, making it possible to manipulate their genomes and evaluate the effects of these changes on their biology and pathogenesis. The fundamental insights gleaned from reverse genetics-based studies over the last several years provide a new momentum for the development of designed therapies for the control and prevention of these viral pathogens. This review summarizes the successes and stumbling blocks in the development of reverse genetics technologies for Rift Valley fever virus and their application to the further dissection of its pathogenesis and the design of new therapeutics and safe and effective vaccines.
Bouloy
Michele
M
Institut Pasteur, Unité de Génétique Moléculaire des Bunyavirus, Paris Cedex, France.
Flick
Ramon
R
D000818:Animals; D000998:Antiviral Agents; D023482:Bioterrorism / Q000517:prevention & control; D002460:Cell Line; D006224:Cricetinae; D018076:DNA, Complementary / Q000235:genetics; D005821:Genetic Techniques; D006801:Humans; D051379:Mice; D012367:RNA, Viral / Q000096:biosynthesis / Q000235:genetics*; D012295:Rift Valley Fever / Q000188:drug therapy / Q000517:prevention & control / Q000821:virology; D012296:Rift Valley fever virus / Q000235:genetics* / Q000276:immunology / Q000472:pathogenicity; D014765:Viral Vaccines / Q000235:genetics
D000998:Antiviral Agents; D018076:DNA, Complementary; D012367:RNA, Viral; D014765:Viral Vaccines
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