The good fat: a link between lipid bodies and antigen cross-presentation.
Antigen cross-presentation enables an efficient CD8(+) T cell response against antigens from exogenous sources. In this issue of Immunity, Bougnères et al. (2009) identify lipid bodies as an unexpected new player involved in this complex cellular pathway.
Desjardins
Michel
M
Département de pathologie et biologie cellulaire et Département de microbiologie et immunologie, Université de Montréal, Montréal, Canada. michel.desjardins@umontreal.ca
D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D017951:Antigen Presentation / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D045142:Cross-Priming / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology* / Q000378:metabolism; D019204:GTP-Binding Proteins / Q000276:immunology / Q000378:metabolism; D007110:Immunity, Active; D007371:Interferon-gamma / Q000276:immunology / Q000378:metabolism; D008055:Lipids / Q000276:immunology*; D051379:Mice; D010588:Phagosomes / Q000276:immunology / Q000378:metabolism
C096000:Ifi1 protein, mouse; D008055:Lipids; D007371:Interferon-gamma; D019204:GTP-Binding Proteins