Liquorice health check, Oro-dental implications, and a case report.
Liquorice has an active substance, Glycyrrhizin which inhibits the conversion of precursor cortisol to cortisone by inhibiting the enzyme 11-betahydroxysteroid dehydrogenase. When imbibed, liquorice acts like hyperaldosteronism which presents with typical symptoms including high blood pressure, low blood potassium, and muscle pain and weakness. This article appraises physiological and pharmacological effects on health of liquorice, critiques products containing liquorice, describes a typical case report of liquorice-induced hypertension, and appraises oral effects from consumption of liquorice products.
Touyz
Louis Z G
LZ
Department of Periodontics Faculty of Dentistry, McGill University, 3640 University Street, Montreal, QC, Canada H3Y 2B2.
BMJ. 1997 Mar 8;314(7082):731-2
9116553
J Contemp Dent Pract. 2008 Mar 01;9(3):1-15
18335114
Harvey Lect. 2004-2005;100:71-101
16970175
N Engl J Med. 1991 Oct 24;325(17):1223-7
1922210
J Commun Dis. 1997 Jun;29(2):91-9
9282507
Nihon Jinzo Gakkai Shi. 1994 Nov;36(11):1308-14
7853765
Free Radic Biol Med. 1997;23(2):302-13
9199893
J Hum Hypertens. 2006 Jun;20(6):465-6
16543912
Am J Gastroenterol. 2001 Aug;96(8):2432-7
11513186
Indian J Med Res. 1993 Apr;98:69-74
8344734
J Hum Hypertens. 2000 Feb;14(2):83-90
10723112
J Gastroenterol Hepatol. 1999 Nov;14(11):1093-9
10574137
MMWR Morb Mortal Wkly Rep. 2007 Mar 2;56(8):161-5
17332726
Hypertension. 2007 Jan;49(1):69-75
17159087
J Clin Endocrinol Metab. 2003 Jun;88(6):2384-92
12788832
J Am Coll Nutr. 2007 Jun;26(3):209-18
17634165
Drug Chem Toxicol. 1998 Aug;21(3):355-70
9706466
J R Soc Promot Health. 2000 Jun;120(2):83-9
10944880
Cancer. 1997 Apr 15;79(8):1494-500
9118029
Crit Rev Clin Lab Sci. 2003 Jun;40(3):295-335
12892318
J Pediatr. 2001 May;138(5):715-20
11343049
Neth J Med. 2005 Apr;63(4):119-20
15869038
Int J Cardiol. 2008 Mar 14;124(3):e42-4
17320224
Scand J Gastroenterol. 1979;14(5):605-7
493863
Expert Rev Cardiovasc Ther. 2006 Jan;4(1):111-7
16375633
J Clin Hypertens (Greenwich). 2008 Feb;10(2):153-7
18256580
Eur Neurol. 1992;32(1):44-51
1563455
Phytother Res. 2000 Dec;14(8):581-91
11113992
Am J Nephrol. 2000 Mar-Apr;20(2):145-8
10773616
Antiviral Res. 1989 Jun-Jul;11(5-6):255-61
2572198
Lancet. 2003 Jun 14;361(9374):2045-6
12814717
Nurse Pract. 2005 Oct;30(10):16-8, 23-4, 26-7 passim; quiz 36-7
16217418
Regul Toxicol Pharmacol. 2006 Dec;46(3):167-92
16884839
Yakugaku Zasshi. 2000 Oct;120(10):849-62
11082698
J Hum Hypertens. 2001 Aug;15(8):549-52
11494093