title: Functional neuroanatomy of the encoding and retrieval processes of verbal episodic memory in MCI.
abstract: BACKGROUND
  The goal of this study was to explore the association between disease severity and performance on brain activation associated with episodic memory encoding and retrieval in persons with mild cognitive impairment (MCI).
  
  
  METHODS
  This was achieved by scanning 12 MCI persons and 10 age- and education-matched healthy controls while encoding words and while retrieving them in a recognition test.
  
  
  RESULTS
  Behaviorally, there was no significant group difference on recognition performance. However, MCI and healthy controls showed different patterns of cerebral activation during encoding. While most of these differences demonstrated reduced activation in the MCI group, there were areas of increased activation in the left ventrolateral prefrontal cortex. Reduced activation was found in brain areas known to be either structurally compromised or hypometabolic in Alzheimer's disease (AD). In contrast, very few group differences were associated with retrieval. Correlation analyses indicated that increased disease severity, as measured with the Mattis Dementia Rating Scale, was associated with smaller activation of the right middle and superior temporal gyri. In contrast, recognition success in MCI persons was associated with larger activation of the left ventrolateral prefrontal cortex during the encoding phase.
  
  
  CONCLUSIONS
  Overall, our results indicate that most of the memory-related cerebral network changes in MCI persons occur during the encoding phase. They also suggest that a prefrontal compensatory mechanism could occur in parallel with the disease-associated reduction of cerebral activation in temporal areas.
authors.affiliation: Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal, Canada. francis.clement@umontreal.ca
authors.forename: Francis
authors.initials: F
authors.lastname: Clément
authors.forename: Sylvie
authors.initials: S
authors.lastname: Belleville
authors.forename: Samira
authors.initials: S
authors.lastname: Mellah
mesh_terms: D000368:Aged; D001921:Brain / Q000503:physiopathology*; D016022:Case-Control Studies; D003072:Cognition Disorders / Q000503:physiopathology* / Q000523:psychology; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D011939:Mental Recall; D008875:Middle Aged; D009483:Neuropsychological Tests; D017397:Prefrontal Cortex / Q000503:physiopathology; D021641:Recognition, Psychology; D012720:Severity of Illness Index; D013702:Temporal Lobe / Q000503:physiopathology; D014705:Verbal Behavior; D014796:Visual Perception