title: Multiple inflammatory myofibroblastic tumors involving lung and mediastinum: a rare clinical entity.
abstract: OBJECTIVE
  Inflammatory myofibroblastic tumors (IMT) are a rare clinical entity. We retrospectively reviewed the clinicopathological characteristics and prognosis for all patients with surgically resected IMTs of the lung at our institution.
  
  
  METHODS
  From January 1995 through February 2007, 16 patients, 9 men and 7 women ranging in age from 18 to 64 years with a median age of 46 years, were admitted to our hospital for IMT of the lung, mediastinum and thoracic outlet. Nine of them (56.3 %) had a history of pneumonia, while in the rest it was documented as an incidental finding on chest X-ray. Five of our patients (31.3 %) were under immunosuppressive therapy. CT scan was the diagnostic tool routinely used and PET performed turned out to be positive in 5 cases. Wedge resection was performed in the majority of cases along with 2 lobectomies and 2 segmentectomies. The resected lesions were studied histologically and immunohistochemically. There were no operative deaths. Follow-up was complete in all patients and ranged from 9 months to 135 months. No recurrence was observed.
  
  
  RESULTS
  Overall 5-year survival was 93.8 %. Fifteen patients are still alive and the cause of death in one case was not related to the pseudotumor. Cox regression analysis was performed for different factors such as age, sex, previous pneumonia and immunosuppression. None of them was found to play a role in the development of an IMT. The type of intervention also did not seem to affect the prognosis in our series.
  
  
  CONCLUSIONS
  IMTs are a rare clinical entity. An accurate preoperative diagnosis is difficult and complete resection remains the treatment of choice and leads to an excellent survival.
authors.affiliation: Thoracic and Cardiovascular Surgery, Medical School of Hannover, Hannover, Germany. kallatha@otenet.gr
authors.forename: K
authors.initials: K
authors.lastname: Athanassiadi
authors.forename: F
authors.initials: F
authors.lastname: Laenger
authors.forename: N
authors.initials: N
authors.lastname: Dickgreber
authors.forename: A
authors.initials: A
authors.lastname: Haverich
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D033162:Incidental Findings; D053208:Kaplan-Meier Estimate; D008297:Male; D008477:Mediastinal Diseases / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*; D008875:Middle Aged; D016726:Plasma Cell Granuloma, Pulmonary / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*; D011013:Pneumonectomy; D049268:Positron-Emission Tomography; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D013908:Thoracotomy; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D055815:Young Adult