Penetration of colistin into cerebrospinal fluid.
Colistin penetration into the cerebrospinal fluid (CSF) was studied in five critically ill adult patients receiving colistin methanesulfonate for infections by multiresistant gram-negative bacilli. Colistin concentrations were determined in paired serum and CSF samples, with the latter taken by lumbar puncture, with the exception of one patient with an external ventriculostomy. CSF-to-serum ratios (0.051 to 0.057) for all study patients coincided at all sampling times. The low level (5%) of penetration suggests inadequate bactericidal colistin concentrations in the CSF.
Markantonis
S L
SL
Department of Pharmaceutical Technology, Laboratory of Biopharmaceutics and Pharmacokinetics, Faculty of Pharmacy, University of Athens, Panepistimiopolis, 157.71 Athens, Greece. kyroudi@pharm.uoa.gr
Markou
N
N
Fousteri
M
M
Sakellaridis
N
N
Karatzas
S
S
Alamanos
I
I
Dimopoulou
E
E
Baltopoulos
G
G
D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000134:cerebrospinal fluid*; D003091:Colistin / Q000097:blood / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
D000900:Anti-Bacterial Agents; D003091:Colistin
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