title: Serum adiponectin and resistin levels in major depressive disorder.
abstract: OBJECTIVE
  To examine the role of the adipose-tissue-derived low-grade inflammation markers adiponectin and resistin in major depressive disorder (MDD) in a population-based sample.
  
  
  METHODS
  Serum levels of adiponectin and resistin were measured from 70 DSM-IV MDD subjects and 70 healthy controls. Depression severity was assessed with the 29-item Hamilton Depression Rating Scale.
  
  
  RESULTS
  The MDD group had lowered serum adiponectin levels. Regression modelling with adjustments for age, gender, overweight, several socioeconomic and lifestyle factors, coronary heart disease and metabolic syndrome showed that each 5.0 microg/ml decrease in serum adiponectin increased the likelihood of MDD by approximately 20% (P = 0.01). The resistin levels correlated with atypical (P = 0.02), but not with typical depressive symptoms (P = 0.12).
  
  
  CONCLUSIONS
  Our findings suggest that the lowered adiponectin levels in MDD are depression-specific and not explained by conventional low adiponectin-related factors such as such as coronary heart disease and metabolic disorders.
authors.affiliation: Department of Psychiatry, Kuopio University Hospital and University of Kuopio, Kuopio, Finland. Soili.Lehto@kuh.fi
authors.forename: S M
authors.initials: SM
authors.lastname: Lehto
authors.forename: A
authors.initials: A
authors.lastname: Huotari
authors.forename: L
authors.initials: L
authors.lastname: Niskanen
authors.forename: T
authors.initials: T
authors.lastname: Tolmunen
authors.forename: H
authors.initials: H
authors.lastname: Koivumaa-Honkanen
authors.forename: K
authors.initials: K
authors.lastname: Honkalampi
authors.forename: H
authors.initials: H
authors.lastname: Ruotsalainen
authors.forename: K-H
authors.initials: KH
authors.lastname: Herzig
authors.forename: H
authors.initials: H
authors.lastname: Viinamäki
authors.forename: J
authors.initials: J
authors.lastname: Hintikka
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D003327:Coronary Disease; D003710:Demography; D003865:Major Depressive Disorder / Q000378:metabolism* / Q000503:physiopathology / Q000523:psychology; D005260:Female; D006801:Humans; D008019:Life Style; D008297:Male; D008875:Middle Aged; D050177:Overweight; D052243:Resistin / Q000097:blood*; D012720:Severity of Illness Index; D012959:Socioeconomic Factors
chemical_list: D052242:Adiponectin; D052243:Resistin