title: Cyanoacetamide multicomponent reaction (I): Parallel synthesis of cyanoacetamides.
abstract: Cyanoacetic acid derivatives are the starting materials for a plethora of multicomponent reaction (MCR) scaffolds. However the diversity of these scaffolds is hampered by the low variability of the cyanoacetic acid derivatives in the past. Here we describe valuable protocols for the parallel synthesis of arrays of cyanoacetamides on a multigram scale and involving very convenient work up by simple filtration and washing. Fifty-two products are described, and several applications are indicated. We foresee our protocol and the resulting derivatives to become very valuable to greatly expanding the large MCR scaffold space of cyanoacetic acid derivatives.
authors.affiliation: University of Pittsburgh, Drug Discovery Institute, Pittsburgh 15261, Pennsylvania, USA.
authors.forename: Kan
authors.initials: K
authors.lastname: Wang
authors.forename: Katrina
authors.initials: K
authors.lastname: Nguyen
authors.forename: Yijun
authors.initials: Y
authors.lastname: Huang
authors.forename: Alexander
authors.initials: A
authors.lastname: Dömling
mesh_terms: D009682:Magnetic Resonance Spectroscopy; D009570:Nitriles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D009570:Nitriles; C031594:2-cyanoacetamide