Chinese medicines as a resource for liver fibrosis treatment.
Liver fibrosis is a condition of abnormal proliferation of connective tissue due to various types of chronic liver injury often caused by viral infection and chemicals. Effective therapies against liver fibrosis are still limited. In this review, we focus on research on Chinese medicines against liver fibrosis in three categories, namely pure compounds, composite formulae and combination treatment using single compounds with composite formulae or conventional medicines. Action mechanisms of the anti-fibrosis Chinese medicines, clinical application, herbal adverse events and quality control are also reviewed. Evidence indicates that some Chinese medicines are clinically effective on liver fibrosis. Strict quality control such as research to identify and monitor the manufacturing of Chinese medicines enables reliable pharmacological, clinical and in-depth mechanism studies. Further experiments and clinical trials should be carried out on the platforms that conform to international standards.
Feng
Yibin
Y
School of Chinese Medicine, The University of Hong Kong, Pokfulam, Hong Kong, PR China. yfeng@hku.hk
Cheung
Kwok-Fan
KF
Wang
Ning
N
Liu
Ping
P
Nagamatsu
Tadashi
T
Tong
Yao
Y
Dig Dis Sci. 2006 Mar;51(3):603-9
16614974
Zhonghua Gan Zang Bing Za Zhi. 2004 Nov;12(11):692-3
15623384
Life Sci. 2005 Feb 25;76(15):1675-90
15698847
Biopharm Drug Dispos. 1997 Nov;18(8):717-25
9373728
Hepatol Res. 2002 Mar;22(3):196-205
11882416
Hepatology. 1999 Oct;30(4):1099-104
10498665
Antiviral Res. 2005 Nov;68(2):75-83
16122816
Arch Toxicol. 2002 Nov;76(11):664-70
12415430
Fitoterapia. 2000 Feb;71(1):25-33
11449466
J Ethnopharmacol. 2008 May 8;117(2):309-17
18372131
Am J Chin Med. 1998;26(3-4):325-32
9862020
Planta Med. 2006 Aug;72(10):865-74
16902852
J Ethnopharmacol. 2007 Jan 19;109(2):318-24
16989967
Hepatology. 2001 Sep;34(3):595-603
11526548
Life Sci. 2004 Mar 19;74(18):2251-63
14987950
Int J Immunopharmacol. 1991;13(2-3):141-6
1906436
J Gastroenterol Hepatol. 2000 Mar;15 Suppl:D84-90
10759225
Anticancer Res. 2006 May-Jun;26(3B):2221-6
16821591
J Clin Gastroenterol. 2005 Apr;39(4 Suppl 2):S158-61
15758652
Planta Med. 2004 Aug;70(8):778-9
15326552
Mol Biosyst. 2006 May;2(5):250-8
16880943
J Pharm Pharmacol. 2004 Apr;56(4):547-56
15099450
J Hepatol. 2003;38 Suppl 1:S38-53
12591185
Biol Pharm Bull. 1997 Apr;20(4):417-20
9145221
Curr Drug Targets Infect Disord. 2001 Aug;1(2):227-40
12455417
Liver Int. 2006 Feb;26(1):8-22
16420505
Hepatol Res. 2001 Jan 1;19(1):31-40
11137478
World J Gastroenterol. 2002 Aug;8(4):679-85
12174378
Toxicol Appl Pharmacol. 2006 Jul 1;214(1):8-15
16387334
Cancer Lett. 2004 Jan 20;203(2):127-37
14732220
Phytother Res. 2009 Jun;23(6):833-9
19107744
J Gastroenterol Hepatol. 1999 Nov;14(11):1093-9
10574137
J Hepatol. 2005 Jul;43(1):117-25
15893842
J Ethnopharmacol. 2005 Feb 10;97(1):7-13
15652268
Am J Chin Med. 2000;28(3-4):351-60
11154048
Hepatobiliary Pancreat Dis Int. 2006 Feb;5(1):48-51
16481282
J Gastroenterol Hepatol. 2007 Jan;22(1):99-111
17201889
Zhongguo Zhong Yao Za Zhi. 2008 May;33(10):1221-5
18720877
Life Sci. 2003 Feb 21;72(14):1563-71
12551745
Phytother Res. 2004 Apr;18(4):306-9
15162366
J Pharm Pharmacol. 2003 Nov;55(11):1561-8
14713368
J Biomed Sci. 2005 Oct;12(5):791-801
16132116
Can J Physiol Pharmacol. 2006 Oct;84(10):967-76
17218962
Hunan Yi Ke Da Xue Xue Bao. 2000 Jun 28;25(3):248-50
12212155
Zhong Yao Cai. 2003 Nov;26(11):795-8
14989060
World J Gastroenterol. 2003 Mar;9(3):529-33
12632512
Acta Med Okayama. 1982 Aug;36(4):277-81
7136858
Zhonghua Gan Zang Bing Za Zhi. 2004 Apr;12(4):245-6
15099485
World J Gastroenterol. 2005 May 21;11(19):2892-9
15902724
Clin Gastroenterol Hepatol. 2004 Nov;2(11):947-56
15551246
J Ethnopharmacol. 2005 Sep 14;100(3):299-305
15905052
J Hepatol. 2005 Nov;43(5):901-10
16171893
Res Commun Mol Pathol Pharmacol. 1998 Nov;102(2):189-204
10100510
J Hepatol. 2006 Oct;45(4):529-38
16879891
J Infect Chemother. 2006 Oct;12(5):227-32
17109084
Chin Med J (Engl). 2000 Jul;113(7):599-601
11776026
Apoptosis. 2005 Oct;10(5):927-39
16151628
J Ethnopharmacol. 2009 Jul 6;124(1):130-6
19536921
Aliment Pharmacol Ther. 2006 Oct 15;24(8):1179-86
17014576
Hepatobiliary Pancreat Dis Int. 2002 May;1(2):207-10
14607740
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2006 Jan;26(1):63-7
16466176
J Hepatol. 1998 Oct;29(4):642-9
9824275
Nihon Rinsho. 1994 Jul;52(7):1823-7
8078202
J Gastroenterol Hepatol. 2000 May;15 Suppl:E20-4
10921377
Nihon Kyobu Shikkan Gakkai Zasshi. 1995 Dec;33(12):1361-1366
8821988
Biol Pharm Bull. 2002 Nov;25(11):1417-21
12419951
J Pharm Pharmacol. 1999 Sep;51(9):1079-84
10528993
Eur Respir J. 1996 Dec;9(12):2691-6
8980988
J Pharm Pharmacol. 2006 May;58(5):659-65
16640835
J Pharm Pharmacol. 2001 May;53(5):763-8
11370717
J Pharm Pharmacol. 1998 Jan;50(1):97-105
9504440
Hepatology. 1999 Jan;29(1):282-4
9862880
Zhonghua Yi Xue Za Zhi. 2003 Jul 10;83(13):1122-5
12921627
Clin Liver Dis. 2003 Feb;7(1):261-87
12691470
Dev Immunol. 1999;7(1):17-22
10636475
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2006 Jan;26(1):23-7
16466167
Scand J Gastroenterol. 2006 Sep;41(9):1087-94
16938723
World J Gastroenterol. 1998 Dec;4(6):548-549
11819368
J Hepatol. 2003 Jun;38(6):762-9
12763369
Ophthalmic Res. 2006;38(6):355-60
17047408
Am Fam Physician. 2006 Sep 1;74(5):756-62
16970019
Am J Chin Med. 2006;34(1):99-114
16437743
J Ethnobiol Ethnomed. 2009 Jan 12;5:2
19138420
World J Gastroenterol. 2005 Aug 28;11(32):4953-6
16124044
Hepatology. 1996 Mar;23(3):552-9
8617437
Phytother Res. 2003 Nov;17(9):1119-22
14595601
Hepatobiliary Pancreat Dis Int. 2003 Aug;2(3):391-6
14599946
World J Gastroenterol. 2004 Nov 15;10(22):3269-73
15484298
Chem Biol Interact. 2008 Feb 15;171(3):283-93
18045581
Nihon Ishinkin Gakkai Zasshi. 2000;41(2):115-9
10777823
Life Sci. 2006 Apr 4;78(19):2226-33
16280138
J Surg Res. 2007 Aug;141(2):183-91
17574589
J Hepatol. 2004 Aug;41(2):242-50
15288473
World J Gastroenterol. 2004 Jul 1;10(13):1923-7
15222038
Gastroenterology. 2000 Feb;118(2):380-9
10648466
Immunopharmacol Immunotoxicol. 2004 May;26(2):285-98
15209364
Biochem J. 2004 Nov 15;384(Pt 1):149-57
15320868
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2002 May;22(5):335-6
12584828
Eur J Gastroenterol Hepatol. 1999 Oct;11(10):1077-83
10524635
Liver. 1993 Aug;13(4):227-31
8377599
Nat Clin Pract Gastroenterol Hepatol. 2007 May;4(5):236-7
17476207
Hepatol Res. 2004 Sep;30(1):34-41
15341772
Am J Chin Med. 2005;33(1):87-94
15844836
Hepatobiliary Pancreat Dis Int. 2004 Feb;3(1):102-5
14969849
N Engl J Med. 1998 Sep 17;339(12):839-41
9738094
Pediatr Surg Int. 2001 Jul;17(5-6):386-9
11527172
Hepatology. 1999 Jan;29(1):149-60
9862861
J Hepatol. 2004 Oct;41(4):584-91
15464238
Liver. 1998 Jun;18(3):180-5
9716228
Dig Dis Sci. 2005 Oct;50(10):1807-12
16187178
J Hepatol. 1998 Feb;28(2):298-306
9514543
Int J Mol Med. 2009 Apr;23(4):477-84
19288023
Acta Pharmacol Sin. 2001 Feb;22(2):183-6
11741525
FASEB J. 2001 Jun;15(8):1335-49
11387231
Clin Exp Pharmacol Physiol. 2008 Mar;35(3):303-9
17973934
Liver Int. 2005 Dec;25(6):1224-32
16343076
Chin Med. 2009 Jun 29;4:12
19558726