title: Small molecule ligands for bulged RNA secondary structures.
abstract: A class of wedge-shaped small molecules has been designed, synthesized, and shown to bind bulged RNA secondary structures. These minimally cationic ligands exhibit good affinity and selectivity for certain RNA bulges as demonstrated in a fluorescent intercalator displacement assay.
authors.affiliation: Department of Chemistry, Roger Adams Laboratory, University of Illinois, Urbana, Illinois 61801, USA.
authors.forename: S Todd
authors.initials: ST
authors.lastname: Meyer
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Hergenrother
mesh_terms: D054856:G-Quadruplexes / Q000187:drug effects*; D007364:Intercalating Agents / Q000494:pharmacology*; D008956:Models, Chemical; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D012313:RNA / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D007364:Intercalating Agents; D012313:RNA
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