title: Endocytosis of lipid-anchored proteins: excluding GEECs from the crowd.
abstract: Endocytosis of glycosylphosphatidylinositol (GPI)-linked proteins via a specific pathway into GPI-enriched early endosomal compartments (GEECs) has been proposed. How sorting into this pathway may take place is unclear. In this issue, Bhagatji et al. (2009. J. Cell Biol. doi:10.1083/jcb.200903102) provide an original mechanism for the sorting of lipid-anchored proteins that involves exclusion of bulky extracellular domains from clathrin-coated pits.
authors.affiliation: Medical Research Council Laboratory of Molecular Biology, Cambridge CB20QH, England, UK. ben@mrc-lmb.cam.ac.uk
authors.forename: Ben
authors.initials: B
authors.lastname: Nichols
mesh_terms: D002462:Cell Membrane / Q000737:chemistry / Q000378:metabolism; D002966:Clathrin / Q000378:metabolism; D003034:Coated Pits, Cell-Membrane / Q000378:metabolism; D004705:Endocytosis / Q000502:physiology*; D011992:Endosomes / Q000737:chemistry / Q000378:metabolism; D017261:Glycosylphosphatidylinositols / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism*; D015394:Molecular Structure
chemical_list: D002966:Clathrin; D017261:Glycosylphosphatidylinositols; D008565:Membrane Proteins
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