title: [Influence of black vinegar on itraconazole absorption].
abstract: Itraconazole (ITCZ), a useful oral drug effective against Aspergillus, is reported to cause insufficient blood concentration through unstable enteral absorption. Hypoacidic gastic conditions have been reported to reduce absorption, whereas acidic drinks promote it. We present a case of pulmonary aspergillosis in a subject administered ITCZ with black vinegar, a popular health food in Japan. The 59-year-old man showed high blood concentrations of ITCZ, resulting in good Aspergillosis control. To confirm the efficacy in black vinegar on absorbing ITCZ, we administered ITCZ capsules with and without black vinegar to 10 healthy adults after preparation with a proton pump inhibitor to decrease gastric acidity, and measured blood concentrations of ITCZ and the metabolite OH-ITCZ. Administration of this combination increased ITCZ and OH-ITCZ Cmax significantly. For patients who produce too little gastric juice, black vinegar could thus serve to promote ITCZ capsule absorption.
authors.affiliation: Department of Respiratory Medicine, Respiratory Disease Center, Kitano Hospital, Tazuke Kofukai Medical Research Institute.
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Oguma
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Tabata
authors.forename: Kensaku
authors.initials: K
authors.lastname: Aihara
authors.forename: Masataka
authors.initials: M
authors.lastname: Matsumoto
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Kagioka
authors.forename: Masanobu
authors.initials: M
authors.lastname: Nagano
authors.forename: Motonari
authors.initials: M
authors.lastname: Fukui
mesh_terms: D019342:Acetic Acid / Q000494:pharmacology*; D000328:Adult; D058870:Food, Organic; D006801:Humans; D017964:Itraconazole / Q000493:pharmacokinetics*; D008297:Male; D008875:Middle Aged; D055732:Pulmonary Aspergillosis / Q000188:drug therapy
chemical_list: D017964:Itraconazole; D019342:Acetic Acid