title: A comparative study by age and gender of the pituitary adenoma and ACTH and alpha-MSH secretion in dogs with pituitary-dependent hyperadrenocorticism.
abstract: Pituitary-dependent hyperadrenocorticism (PDH) is frequent in dogs. Little is known about its presentation in different age groups and its characteristics. Dividing the population under study (n=107) into three age groups we observed that 11.2% were young, 51.4% adults and 37.4% aged. Using magnetic resonance, pituitary tumours were intra-sellar (IS) in 30.8% and extra-sellar (ES) in 62.6% and the pars intermedia (PI) was affected in 6.5%. ES are predominant in females and IS in males (p<0.0001). In the adult-aged population, the ES and PI are predominant, while in the young, the IS predominate (p<0.0001). ACTH concentration was greater in the ES vs. IS (p<0.05). alpha-MSH did not present significant differences according to tumour size, showing a negative correlation (r=-0.47; p<0.01) vs. ACTH. Differences in adenoma size according to gender and their age-related frequency of apparition could be because of different origins of the corticotrophinoma.
authors.affiliation: U. Endocrinología, Htal. Escuela de Medicina Veterinaria, Facultad de Ciencias Veterinarias, Universidad de Buenos Aires, Av. Chorroarín 280, 1427 Ciudad, Autónoma de Buenos Aires, Argentina.
authors.forename: M F
authors.initials: MF
authors.lastname: Gallelli
authors.forename: M F
authors.initials: MF
authors.lastname: Cabrera Blatter
authors.forename: V
authors.initials: V
authors.lastname: Castillo
mesh_terms: D049913:ACTH-Secreting Pituitary Adenoma / Q000473:pathology / Q000503:physiopathology / Q000662:veterinary*; D000308:Adrenocortical Hyperfunction / Q000473:pathology / Q000503:physiopathology / Q000662:veterinary*; D000324:Adrenocorticotropic Hormone / Q000378:metabolism*; D000367:Age Factors; D000818:Animals; D004283:Dog Diseases / Q000473:pathology* / Q000503:physiopathology; D004285:Dogs; D005260:Female; D008279:Magnetic Resonance Imaging; D008297:Male; D010902:Pituitary Gland / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D010911:Pituitary Neoplasms / Q000473:pathology / Q000503:physiopathology / Q000662:veterinary*; D012189:Retrospective Studies; D012737:Sex Factors; D000521:alpha-MSH / Q000378:metabolism*
chemical_list: D000521:alpha-MSH; D000324:Adrenocorticotropic Hormone