Stranger in a strange land: roles of glycogen turnover in adipose tissue metabolism.
Triglyceride storage in adipose tissue comprises the principal energy reserve in mammals. Additionally glucose can be stored as glycogen in the fed state, primarily in liver and skeletal muscle, for mobilization during times of energy deficit. Adipose tissue also contains glycogen stores albeit at very low levels. The physiological role of glycogen metabolism in adipocytes remains unclear. However, both classical literature and more recent work demonstrate that the dynamic regulation of adipose glycogen may serve as an energy sensing modality in the coordination of glucose and lipid metabolism in adipose tissue, especially during the fasted to fed transition.
Markan
Kathleen R
KR
Department of Medicine, Section of Endocrinology, Diabetes and Metabolism, The University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA.
Jurczak
Michael J
MJ
Brady
Matthew J
MJ
D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D006003:Glycogen / Q000378:metabolism*; D006801:Humans
D006003:Glycogen
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