[Receptors involved in the mechanism of action of topical prostaglandines].
Hypotensive effect to prostaglandins analogs (latanoprost, travoprost, tafluprost) means to increase uveoscleral outflow by action to FP receptors who generated extracellular matrix changes and intermuscular spaces changes. Syntetic prostamides analogs (bimatoprost) have a particulary action with a receptors most and intensive studied. The bimatoprost effect is the consequences to preferated stimulations on the specific receptors who have action only the tissue with prostaglandins activity is important to specify what the bimatoprost have dual effect: to uveoscleral outflow and classic outflow by increase hidraulic conductivity.
Neacsu
Alina Mihaela
AM
Spital Judetean de Urgenta Braila. alinamihaela.neacsu@yahoo.com
D000577:Amides / Q000008:administration & dosage / Q000494:pharmacology; D000959:Antihypertensive Agents / Q000008:administration & dosage* / Q000494:pharmacology*; D000069580:Bimatoprost; D003008:Cloprostenol / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology; D004359:Drug Therapy, Combination; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D000077338:Latanoprost; D009883:Ophthalmic Solutions / Q000008:administration & dosage; D011453:Prostaglandins / Q000008:administration & dosage / Q000378:metabolism* / Q000494:pharmacology; D011460:Prostaglandins F / Q000008:administration & dosage / Q000494:pharmacology; D011461:Prostaglandins F, Synthetic / Q000008:administration & dosage / Q000494:pharmacology; D011982:Receptors, Prostaglandin / Q000378:metabolism*; D000069557:Travoprost
D000577:Amides; D000959:Antihypertensive Agents; D009883:Ophthalmic Solutions; D011453:Prostaglandins; D011460:Prostaglandins F; D011461:Prostaglandins F, Synthetic; D011982:Receptors, Prostaglandin; C034671:prostaglandin F2alpha receptor; C485333:tafluprost; D003008:Cloprostenol; D000077338:Latanoprost; D000069580:Bimatoprost; D000069557:Travoprost