The precursors of memory: models and controversies.
The adaptive immune system has evolved a unique capacity to remember a pathogen through the generation of memory T cells, which rapidly protect the host in the event of reinfection. How memory T cells develop and the relationship between effector and memory T cells has been actively debated in the literature for many years and several models have been proposed to explain the divergent developmental fates of T cell progeny. Here, Nature Reviews Immunology asks four leading researchers in the field to provide their thoughts and opinions on the ontogeny of memory T cells and its implications for vaccine design.
Ahmed
Rafi
R
Emory Vaccine Center, Emory University, Atlanta, Georgia 30322, USA. rahmed@emory.edu
Bevan
Michael J
MJ
Reiner
Steven L
SL
Fearon
Douglas T
DT
D000818:Animals; D002454:Cell Differentiation / Q000276:immunology*; D016207:Cytokines / Q000276:immunology / Q000378:metabolism; D054884:Host-Pathogen Interactions / Q000276:immunology*; D006801:Humans; D007156:Immunologic Memory; D007239:Infections / Q000276:immunology / Q000378:metabolism; D016176:T-Lymphocyte Subsets / Q000276:immunology* / Q000378:metabolism; D014612:Vaccines / Q000276:immunology
D016207:Cytokines; D014612:Vaccines
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