title: [The expression pattern and possible function of microRNA-34a in neurons].
abstract: Using Northern blotting, ISH and FISH, we demonstrated miR-34a expresses with aging in the brain of rhesus monkey and rat. Correspondingly, the same trend was found in the primary cultures of cortical neurons. Moreover, we found that induction of miR-34a led to neuronal apoptosis by targeting BCL-2. Our study suggests that miR-34a may play critical roles in neuronal development and ageing.
authors.affiliation: Institute of Molecular and Chemical Biology, East China Normal University, Shanghai 200062, China.
authors.forename: Yan Ting
authors.initials: YT
authors.lastname: Qi
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhao
authors.forename: Zhi
authors.initials: Z
authors.lastname: Zhang
authors.forename: Dan
authors.initials: D
authors.lastname: Li
authors.forename: Ji Yi
authors.initials: JY
authors.lastname: Gu
authors.forename: Xiao Nan
authors.initials: XN
authors.lastname: Fu
authors.forename: Xiao Na
authors.initials: XN
authors.lastname: Chen
authors.forename: Chong Gang
authors.initials: CG
authors.lastname: Yuan
authors.forename: Li Hui
authors.initials: LH
authors.lastname: Lai
mesh_terms: D000375:Aging / Q000235:genetics; D000818:Animals; D017209:Apoptosis / Q000235:genetics; D002478:Cells, Cultured; D005260:Female; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D006801:Humans; D008253:Macaca mulatta / Q000235:genetics*; D035683:MicroRNAs / Q000235:genetics*; D009474:Neurons / Q000166:cytology / Q000378:metabolism*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism; D051381:Rats
chemical_list: D035683:MicroRNAs; D019253:Proto-Oncogene Proteins c-bcl-2