title: [Incidence and onset time of fentanyl-induced cough depends on the dose of IV fentanyl].
abstract: BACKGROUND
  IV fentanyl en bolus can provoke cough reflex. We evaluated the effects of the IV fentanyl dose on the incidence and onset time of fentanyl-induced cough.
  
  
  METHODS
  Tree hundred and eighteen ASA physical status I - II patients scheduled for oral surgery under general anesthesia were randomly assigned to receive 1 microg x kg(-1), 3 microg x kg(-1) or 5 microg x kg(-1) of IV fentanyl (n = 106 for each group). We recorded, in each patient, presence/absence and onset time, if present, of cough reflex for 60 seconds after fentanyl injection.
  
  
  RESULTS
  The incidences of fentanyl-induced cough were 6.6%, 22.5%, and 44.3% in the 1 microg x kg(-1), 3 microg x kg(-1), and 5 microg x kg(-1) groups, respectively. The onset times of fentanyl-induced cough were 29.0 +/- 11.8 seconds, 22.5 +/- 7.9 seconds, and 19.5 +/- 7.0 seconds in the 1 microg x kg(-1), 3 microg x kg(-1), and 5 microg x kg(-1) groups, respectively.
  
  
  CONCLUSIONS
  The results indicated that the incidence of fentanyl-induced cough increased, and the onset time decreased, with the increasing dose of fentanyl.
authors.affiliation: Department of Oral Health and Clinical Science, Division of Dental Anesthesiology, Suidoubashi Hospital Dental Anesthesia/Orofacial Pain Center, Tokyo 160-0023.
authors.forename: Kazumi
authors.initials: K
authors.lastname: Iida
authors.forename: Mariko
authors.initials: M
authors.lastname: Handa
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Fukuda
authors.forename: Naoko
authors.initials: N
authors.lastname: Saita
authors.forename: Masataka
authors.initials: M
authors.lastname: Kasahara
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Koukita
authors.forename: Akiko
authors.initials: A
authors.lastname: Urabe
authors.forename: Masakazu
authors.initials: M
authors.lastname: Hayashida
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Ichinohe
authors.forename: Yuzuru
authors.initials: Y
authors.lastname: Kaneko
mesh_terms: D000293:Adolescent; D000328:Adult; D000768:Anesthesia, General; D018686:Anesthetics, Intravenous / Q000008:administration & dosage* / Q000009:adverse effects*; D003371:Cough / Q000139:chemically induced* / Q000453:epidemiology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage* / Q000009:adverse effects*; D006801:Humans; D015994:Incidence; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D055815:Young Adult
chemical_list: D018686:Anesthetics, Intravenous; D005283:Fentanyl