Communication, encouragement, and cancer screening in families with and without mutations for hereditary nonpolyposis colorectal cancer: a pilot study.
OBJECTIVE
Known and suspected mutation carriers for hereditary nonpolyposis colorectal cancer are advised to have colonoscopies every 1 to 2 years to detect colorectal cancer. Little is known about colonoscopy completion in families suspected of having hereditary nonpolyposis colorectal cancer but without identified mutations.


METHODS
This study examined the effect of communication and encouragement on colonoscopy in families with and without known mutations. Twenty-three respondents from 11 families with indeterminate genetic test results were matched with 23 respondents from 11 families with mutation-positive results. Hierarchical modeling examined the effects of relational characteristics on time since last colonoscopy in index cases and their first-degree relatives.


RESULTS
Nearly one fifth of respondents were not screening appropriately. Time since last screening did not differ according to family mutation status. However, respondents who communicated about risk and received encouragement to screen from a greater proportion of named family members, and those who had a greater proportion of named family members involved in both communication and encouragement were significantly more likely to have a shorter time interval since last colonoscopy.


CONCLUSIONS
Identifying patterns of interaction within at-risk families, regardless of gene mutation status, may be one avenue for promoting screening adherence.
Ersig
Anne L
AL
Social and Behavioral Research Branch, National Human Genome Research Institute, National Institutes of Health Bethesda, Maryland, USA. anne-ersig@uiowa.edu
Williams
Janet K
JK
Hadley
Donald W
DW
Koehly
Laura M
LM
D000328:Adult; D016022:Case-Control Studies; D003113:Colonoscopy / Q000706:statistics & numerical data; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000175:diagnosis* / Q000235:genetics / Q000523:psychology; D003142:Communication; D003376:Counseling / Q000706:statistics & numerical data; D055088:Early Detection of Cancer / Q000523:psychology / Q000706:statistics & numerical data; D005190:Family; D005260:Female; D020022:Genetic Predisposition to Disease; D006293:Health Promotion / Q000379:methods / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000502:physiology; D010865:Pilot Projects
Semin Oncol Nurs. 2004 Aug;20(3):186-95
15491028
Eur J Cancer Care (Engl). 2008 May;17(3):221-32
18419625
Psychooncology. 2008 Aug;17(8):746-55
18615871
JAMA. 2006 Sep 27;296(12):1507-17
17003399
JAMA. 2005 Apr 27;293(16):2028-30
15855438
Genet Med. 2009 Jan;11(1):35-41
19125126
Genet Med. 2008 Jan;10(1):19-32
18197053
Soc Sci Med. 2000 Sep;51(6):843-57
10972429
Am J Prev Med. 2003 Oct;25(3):187-94
14507524
Gastroenterology. 2000 May;118(5):829-34
10784581
Psychooncology. 2009 Nov;18(11):1208-15
19177338
Cancer. 2009 Sep 15;115(18):4071-9
19536903
Clin Gastroenterol Hepatol. 2006 Apr;4(4):489-98
16616355
J Clin Oncol. 2004 Jan 1;22(1):39-44
14701766
Arch Intern Med. 2003 Mar 10;163(5):573-82
12622604
Health Educ Behav. 2005 Oct;32(5):627-39
16148209
J Genet Couns. 2005 Oct;14(5):349-63
16195942
Surg Endosc. 2008 Feb;22(2):527-33
18074184
Cancer. 2005 Jul 15;104(2):273-81
15948171
Nurs Res. 2007 Jul-Aug;56(4 Suppl):S40-6
17625473
Am J Med Genet C Semin Med Genet. 2003 May 15;119C(1):78-86
12704641
Health Psychol. 2002 Jan;21(1):3-15
11846342
J Med Genet. 2005 Oct;42(10):749-55
15784723
Genet Test. 2005 Spring;9(1):54-65
15857188
Am J Gastroenterol. 2003 Jun;98(6):1410-6
12818289
Ann Behav Med. 2007 Nov-Dec;34(3):275-86
18020937
Gastroenterology. 2005 Aug;129(2):415-21
16083698
J Med Genet. 2005 Jun;42(6):491-6
15937084
JAMA. 1997 Mar 19;277(11):915-9
9062331
Genet Med. 2005 Apr;7(4):239-45
15834241
Gastroenterology. 1999 Jun;116(6):1453-6
10348829