title: A novel antifungal anthraquinone from seeds of Aegle marmelos Correa (family Rutaceae).
abstract: A new anthraquinone, 1-methyl-2-(3'-methyl-but-2'-enyloxy)-anthraquinone (1) has been isolated from seeds of Aegle marmelos Correa and was characterized on the basis of spectral analysis (UV, IR, 1H NMR, 13C NMR, 2D NMR and mass spectroscopy). The compound exhibited significant antifungal activity against pathogenic strains of Aspergillus species and Candida albicans in disc diffusion assay (MIC value of 6.25 microg/disc), microbroth dilution and percent spore germination inhibition assays (MIC value of 31.25-62.5 microg/ml).
authors.affiliation: Department of Chemistry, Banaras Hindu University, Varanasi-221005, India.
authors.forename: Bhuwan B
authors.initials: BB
authors.lastname: Mishra
authors.forename: Navneet
authors.initials: N
authors.lastname: Kishore
authors.forename: Vinod K
authors.initials: VK
authors.lastname: Tiwari
authors.forename: Desh D
authors.initials: DD
authors.lastname: Singh
authors.forename: Vyasji
authors.initials: V
authors.lastname: Tripathi
mesh_terms: D045471:Aegle / Q000737:chemistry*; D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001230:Aspergillus / Q000187:drug effects*; D002176:Candida albicans / Q000187:drug effects*; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D012639:Seeds
chemical_list: C550894:1-methyl-2-(3'-methyl-but-2'-enyloxy)anthraquinone; D000880:Anthraquinones; D000935:Antifungal Agents; D010936:Plant Extracts