title: Importance of TNF-related apoptosis-inducing ligand in pathogenesis of interstitial cystitis.
abstract: BACKGROUND
  Although interstitial cystitis is an inflammatory disease, its etiopathogenesis is not clearly understood. The objective of the present study is to investigate the distribution of TNF-related apoptosis-inducing ligand (TRAIL) and its receptors in bladder biopsy samples of patients diagnosed with interstitial cystitis and the role of TRAIL in the pathogenesis of interstitial cystitis.
  
  
  METHODS
  TRAIL and its receptors were stained immunohistochemically in bladder biopsy samples of 27 patients diagnosed with interstitial cystitis, and the samples were evaluated independently by two pathologists and were scored in terms of expression intensity and distribution.
  
  
  RESULTS
  An evaluation of the results of the statistical analysis showed that the TRAIL-R4 receptor was immunohistochemically stained with a higher score than TRAIL-R1, TRAIL-R2, TRAIL-R3 receptors and TRAIL, with a statistically significant difference (P < 0.05).
  
  
  CONCLUSIONS
  These findings indicate that TRAIL-R4 is the predominant receptor in the interstitial cystitis inflammation.
authors.affiliation: Faculty of Medicine, Department of Urology, Akdeniz University, Antalya 07070, Turkey.
authors.forename: Omer
authors.initials: O
authors.lastname: Kutlu
authors.forename: Erdem
authors.initials: E
authors.lastname: Akkaya
authors.forename: Ismail Turker
authors.initials: IT
authors.lastname: Koksal
authors.forename: Ibrahim Cumhur
authors.initials: IC
authors.lastname: Bassorgun
authors.forename: Mehmet Akif
authors.initials: MA
authors.lastname: Ciftcioglu
authors.forename: Salih
authors.initials: S
authors.lastname: Sanlioglu
authors.forename: Erdal
authors.initials: E
authors.lastname: Kukul
mesh_terms: D001706:Biopsy; D018856:Cystitis, Interstitial / Q000209:etiology* / Q000473:pathology; D006801:Humans; D053220:Receptors, TNF-Related Apoptosis-Inducing Ligand / Q000032:analysis / Q000502:physiology; D053221:TNF-Related Apoptosis-Inducing Ligand / Q000032:analysis / Q000502:physiology*; D001743:Urinary Bladder / Q000737:chemistry / Q000473:pathology
chemical_list: D053220:Receptors, TNF-Related Apoptosis-Inducing Ligand; D053221:TNF-Related Apoptosis-Inducing Ligand
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