title: Identification of a novel cytosolic aldehyde dehydrogenase allele, ALDH1A1*4.
abstract: This paper reports the identification of a novel cytosolic aldehyde dehydrogenase 1 ( ALDH1A1 ) allele. One hundred and sixty-two Indo-Trinidadian and 85 Afro-Trinidadian individuals were genotyped. A novel ALDH1A1 allele, ALDH1A1*4 , was identified in an Indo-Trinidadian alcoholic with an A inserted at position -554 relative to the translational start site, +1. It was concluded that a wider cross-section of individuals needs to be evaluated in order to determine the representative frequency of the allele, and to see if it is associated with risk of alcoholism.
authors.affiliation: Pharmacology Unit, Department of Paraclinical Sciences, Faculty of Medical Sciences, The University of the West Indies, St Augustine, Trinidad and Tobago. smmatrix2k1@yahoo.com
authors.forename: Shelley M
authors.initials: SM
authors.lastname: Moore
authors.forename: Tiebing
authors.initials: T
authors.lastname: Liang
authors.forename: Tamara J
authors.initials: TJ
authors.lastname: Graves
authors.forename: Kevin M
authors.initials: KM
authors.lastname: McCall
authors.forename: Lucinda G
authors.initials: LG
authors.lastname: Carr
authors.forename: Cindy L
authors.initials: CL
authors.lastname: Ehlers
mesh_terms: D000444:Aldehyde Dehydrogenase / Q000235:genetics*; D000483:Alleles; D001483:Base Sequence; D003600:Cytosol / Q000201:enzymology*; D017931:DNA Primers; D005838:Genotype; D006801:Humans; D016133:Polymerase Chain Reaction; D014300:Trinidad and Tobago
chemical_list: D017931:DNA Primers; D000444:Aldehyde Dehydrogenase
references.citation: Eur J Biochem. 1998 Feb 1;251(3):549-57
references.pmid: 9490025
references.citation: J Biochem Mol Toxicol. 2003;17(1):7-23
references.pmid: 12616643
references.citation: J Stud Alcohol Drugs. 2007 Mar;68(2):192-6
references.pmid: 17286337
references.citation: Biochem Soc Trans. 1988 Jun;16(3):241-7
references.pmid: 3181606
references.citation: Am J Hum Genet. 1986 May;38(5):641-8
references.pmid: 3013004
references.citation: Lancet. 1981 Oct 31;2(8253):982
references.pmid: 6117742
references.citation: Pharmacogenetics. 1992 Aug;2(4):139-47
references.pmid: 1306115
references.citation: Pharmacol Biochem Behav. 1990 Feb;35(2):437-42
references.pmid: 2320652
references.citation: Pathol Biol (Paris). 2001 Nov;49(9):676-82
references.pmid: 11762128
references.citation: Alcohol Clin Exp Res. 1984 May-Jun;8(3):319-22
references.pmid: 6377951
references.citation: J Stud Alcohol. 1994 Mar;55(2):149-58
references.pmid: 8189735
references.citation: Enzyme. 1992;46(4-5):239-44
references.pmid: 1292933
references.citation: Ann Hum Genet. 1989 Jan;53(1):1-7
references.pmid: 2729894
references.citation: J Biol Chem. 2001 Aug 31;276(35):32896-904
references.pmid: 11438538
references.citation: Alcohol Clin Exp Res. 1986 Jun;10(3):266-70
references.pmid: 3526948
references.citation: Genomics. 1989 Nov;5(4):857-65
references.pmid: 2591967
references.citation: Biotechniques. 2000 Jul;29(1):52, 54
references.pmid: 10907076
references.citation: J Biol Chem. 1995 Jul 21;270(29):17521-7
references.pmid: 7615557
references.citation: Alcohol Clin Exp Res. 2004 Oct;28(10):1481-6
references.pmid: 15597079
references.citation: Alcohol Alcohol. 1994 Jul;29(4):433-8
references.pmid: 7986281
references.citation: Chem Biol Interact. 2000 Dec 1;129(1-2):1-19
references.pmid: 11154732
references.citation: Biochem Biophys Res Commun. 1995 Jun 6;211(1):144-51
references.pmid: 7779080
references.citation: Alcohol Clin Exp Res. 2003 Sep;27(9):1389-94
references.pmid: 14506398
references.citation: Genomics. 1988 Apr;2(3):267-9
references.pmid: 3397064
references.citation: Addiction. 1999 Sep;94(9):1361-70
references.pmid: 10615721