[Study on the relationship between FABP2 Ala54Thr polymorphism and the risk of non-alcoholic fatty liver diseases].
OBJECTIVE
To explore the relationship between FABP2 Ala54Thr polymorphism and the risk of non-alcoholic fatty liver diseases (NFLD).


METHODS
A hospital-based case-control study was conducted and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used to detect FABP2 Ala54Thr genotypes. The cases and controls were interviewed by using the same questionnaire.


RESULTS
The genotype frequencies of Ala54Ala, Ala54Thr and Thr54Thr were 39.7%, 46.6% and 13.7% in cases, and 48.5%, 43.1% and 8.4% in controls. The Thr allele frequency in cases (36.97%) was higher than that in the controls (29.94%)(P = 0.01). Multiple logistic regression results showed that after adjusting other confound factors, the Thr54 Thr genotype was the independent risk factor of NFLD (OR = 1.97, 95% CI: 1.18-3.35).


CONCLUSIONS
FABP2 Thr54Thr genotype might increase the risk of NFLD development.
Peng
Xian'e
X
School of Public Health, Fujian Medical University, Fuzhou 350004, China. fmuxe@163.com
Zhang
Ling
L
Wang
Qingqing
Q
Cui
Xu
X
D000328:Adult; D000368:Aged; D000409:Alanine / Q000235:genetics; D019943:Amino Acid Substitution; D016022:Case-Control Studies; D050556:Fatty Acid-Binding Proteins / Q000235:genetics*; D005234:Fatty Liver / Q000209:etiology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D016133:Polymerase Chain Reaction / Q000379:methods; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D012307:Risk Factors; D013912:Threonine / Q000235:genetics; D055815:Young Adult
C493404:FABP2 protein, human; D050556:Fatty Acid-Binding Proteins; D013912:Threonine; D000409:Alanine