title: Arterial wave reflection in HIV-infected and HIV-uninfected Rwandan women.
abstract: To assess differences in arterial wave reflection, a marker of atherosclerosis, in HIV-positive and HIV-negative Rwandan women, applanation tonometry was performed on 276 HIV(+) and 67 HIV(-) participants. Radial artery pressure waveforms were recorded and central aortic waveforms were derived by validated transfer function. Central augmentation index (C-AI), central pulse pressure (C-PP), and peripheral augmentation index (P-AI) were measured. HIV(+) participants were younger and had lower diastolic blood pressure (BP) and 41% of the HIV(+) women were taking antiretroviral therapy (ART). Mean C-AI and P-AI were significantly lower in HIV-infected than in uninfected participants (20.3 +/- 12.0 vs. 25.5 +/- 12.1, p = 0.002 and 74.6 +/- 18.8 vs. 83.7 +/- 20.0, p < 0.001). After age matching, C-AI, C-PP, and P-AI were similar among the groups. On multivariate analysis, age, heart rate, weight, and mean arterial pressure were independently associated with C-AI (R(2) = 0.33, p < 0.0001). Among HIV-infected women, current CD4 count did not correlate with C-AI (Rho = -0.01, p = 0.84), C-PP (Rho = 0.09, p = 0.16), or P-AI (Rho = -0.01, p = 0.83). In conclusion, HIV infection was not associated with increased arterial wave reflection in women with little exposure to antiretroviral therapy and without CV risk factors. Whether long-term ART increases measures of arterial stiffness remains unknown.
authors.affiliation: Division of Cardiovascular Medicine, State University of New York Downstate Medical Center, Brooklyn, New York 11203-2098, USA. jason.lazar@downstate.edu
authors.forename: Jason M
authors.initials: JM
authors.lastname: Lazar
authors.forename: Xi
authors.initials: X
authors.lastname: Wu
authors.forename: Qiuhu
authors.initials: Q
authors.lastname: Shi
authors.forename: Abel
authors.initials: A
authors.lastname: Kagame
authors.forename: Mardge
authors.initials: M
authors.lastname: Cohen
authors.forename: Agnes
authors.initials: A
authors.lastname: Binagwaho
authors.forename: Louis
authors.initials: L
authors.lastname: Munyakazi
authors.forename: Louis
authors.initials: L
authors.lastname: Salciccioli
authors.forename: Di
authors.initials: D
authors.lastname: Shi
authors.forename: Kathryn
authors.initials: K
authors.lastname: Anastos
mesh_terms: D000328:Adult; D001158:Arteries / Q000473:pathology*; D050197:Atherosclerosis / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008875:Middle Aged; D011674:Pulse; D012432:Rwanda
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