title: Activity in preserved left hemisphere regions predicts anomia severity in aphasia.
abstract: Understanding the neural mechanism that supports preserved language processing in aphasia has implications for both basic and applied science. This study examined brain activation associated with correct picture naming in 15 patients with aphasia. We contrasted each patient's activation to the activation observed in a neurologically healthy control group, allowing us to identify regions with unusual activity patterns. The results revealed that increased activation in preserved left hemisphere areas is associated with better naming performance in aphasia. This relationship was linear in nature; progressively less cortical activation was associated with greater severity of anomia. These findings are consistent with others who suggests that residual language function following stroke relies on preserved cortical areas in the left hemisphere.
authors.affiliation: Department of Communication Sciences and Disorders, University of South Carolina, Columbia, SC 29208, USA. jfridrik@sc.edu
authors.forename: Julius
authors.initials: J
authors.lastname: Fridriksson
authors.forename: Leonardo
authors.initials: L
authors.lastname: Bonilha
authors.forename: Julie M
authors.initials: JM
authors.lastname: Baker
authors.forename: Dana
authors.initials: D
authors.lastname: Moser
authors.forename: Chris
authors.initials: C
authors.lastname: Rorden
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000849:Anomia / Q000209:etiology* / Q000473:pathology*; D001037:Aphasia / Q000150:complications*; D001921:Brain / Q000098:blood supply / Q000503:physiopathology*; D001931:Brain Mapping; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009275:Names; D009483:Neuropsychological Tests; D010100:Oxygen / Q000097:blood; D010364:Pattern Recognition, Visual / Q000502:physiology; D010775:Photic Stimulation / Q000379:methods; D011237:Predictive Value of Tests; D012044:Regression Analysis
chemical_list: D010100:Oxygen
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