[The investigation for the neuropeptides of nasal septum in perennial allergic rhinitis patient].
OBJECTIVE
To investigate the expression of neuropeptides in the nasal septum of the perennial allergic rhinitis patients, and the mechanism of the alleviation effect of nasal septum rectification to allergic rhinitis.


METHODS
Forty-five patients with deviation of nasal septum (20 with allergic rhinitis and 25 without), who undergone nasal septum rectification in Changhai hospital during Jun to Dec, 2007, were included in this research. The levels of SP, VIP, CGRP of the nasal septum were determined by radioimmunoassay.


RESULTS
In the normal controls, the SP, VIP and CGRP levels of the nasal septal cartilages were lower than that of the nasal septal bones (P<0.05), while in the perennial allergic rhinitis patients group, there were no statistical significance between the SP, VIP levels of the nasal septal cartilages and that of the nasal septal bones (P>0.05), and the CGRP level of the nasal septal cartilages was higher than that of the nasal septal bones (P<0.05). The SP, VIP levels of the nasal septal cartilages in the perennial allergic rhinitis patients group were higher than that in the normal controls (P<0.05), and there were no statistical significance between the levels of the nasal septal bones in the two groups (P>0.05). There were no statistical significance between the CGRP levels of the nasal septal cartilages in the two groups (P>0.05), neither did that of the nasal septal bones in the two groups (P>0.05).


CONCLUSIONS
The SP level of the nasal septum in the perennial allergic rhinitis patients was higher than that in the normal controls, which was more obvious in the nasal septal cartilages. The VIP level of the nasal septum in the perennial allergic rhinitis patients was higher than that in the normal controls, which was more obvious in the nasal septal cartilages. There were no statistical significance between the CGRP levels of the nasal septum in the perennial allergic rhinitis patients and the normal controls.
Zhu
Qiubei
Q
Department of Otolaryngology Head and Neck Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, 200003, China.
Zhang
Suqin
S
Wu
Jingxian
J
Tang
Haihong
H
D015740:Calcitonin Gene-Related Peptide / Q000378:metabolism*; D016022:Case-Control Studies; D006801:Humans; D009297:Nasal Mucosa / Q000378:metabolism; D009300:Nasal Septum / Q000378:metabolism*; D012221:Rhinitis, Allergic, Perennial / Q000378:metabolism*; D013373:Substance P / Q000378:metabolism*; D014660:Vasoactive Intestinal Peptide / Q000378:metabolism*
D013373:Substance P; D014660:Vasoactive Intestinal Peptide; D015740:Calcitonin Gene-Related Peptide