title: Genetics: breast cancer as an exemplar.
abstract: Genetic testing for adult-onset diseases is now available. One such test is for the mutations present in the BRCA gene that result in a significantly higher risk for the development of breast cancer or ovarian cancer. Women who have one of these mutations face difficult choices in terms of increased surveillance or prophylactic surgeries. Examining experiences of women with BRCA mutations can serve as an exemplar for other populations at risk for genetically associated adult-onset diseases.
authors.affiliation: Department of Women, Children and Family Health Science, College of Nursing, University of Illinois at Chicago, Chicago, IL 60612, USA. hamilr@uic.edu
authors.forename: Rebekah
authors.initials: R
authors.lastname: Hamilton
mesh_terms: D000223:Adaptation, Psychological; D000328:Adult; D001294:Attitude to Health; D001943:Breast Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000517:prevention & control; D005260:Female; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D005817:Genetic Counseling; D020022:Genetic Predisposition to Disease / Q000235:genetics / Q000517:prevention & control; D005820:Genetic Testing / Q000379:methods / Q000523:psychology; D006801:Humans; D008408:Mastectomy; D009154:Mutation / Q000235:genetics; D009386:Neoplastic Syndromes, Hereditary / Q000175:diagnosis / Q000235:genetics / Q000517:prevention & control; D024802:Nurse's Role; D010052:Ovariectomy; D010375:Pedigree; D017410:Practice Guidelines as Topic; D012017:Referral and Consultation; D018570:Risk Assessment; D040242:Risk Reduction Behavior; D016387:Women's Health
references.citation: Nurs Sci Q. 2007 Jul;20(3):254-64
references.pmid: 17595406
references.citation: J Genet Couns. 2009 Oct;18(5):418-35
references.pmid: 19479365
references.citation: Psychooncology. 2008 Aug;17(8):767-73
references.pmid: 17992698
references.citation: J Genet Couns. 2008 Aug;17(4):314-26
references.pmid: 18481164
references.citation: Br J Cancer. 2006 Mar 27;94(6):814-9
references.pmid: 16495917
references.citation: N Engl J Med. 2002 May 23;346(21):1609-15
references.pmid: 12023992
references.citation: Am J Hum Genet. 2003 May;72(5):1117-30
references.pmid: 12677558
references.citation: Psychooncology. 2001 May-Jun;10(3):231-41
references.pmid: 11351375
references.citation: Fam Cancer. 2005;4(2):121-6
references.pmid: 15951962
references.citation: Clin Genet. 2006 Dec;70(6):462-72
references.pmid: 17100990
references.citation: Patient Educ Couns. 2001 Mar;42(3):213-24
references.pmid: 11164320
references.citation: Clin Breast Cancer. 2007 Dec;7(11):875-82
references.pmid: 18269778
references.citation: Prev Med. 2002 Oct;35(4):343-8
references.pmid: 12453711
references.citation: Sociol Health Illn. 2006 Nov;28(7):969-88
references.pmid: 17163862
references.citation: Fam Cancer. 2005;4(2):163-7
references.pmid: 15951968
references.citation: Genet Test. 2004 Fall;8(3):235-9
references.pmid: 15727245
references.citation: Soc Sci Med. 2004 Aug;59(3):553-65
references.pmid: 15144764
references.citation: Clin Genet. 2003 Oct;64(4):317-26
references.pmid: 12974737
references.citation: Qual Health Res. 2006 Jan;16(1):97-118
references.pmid: 16317179
references.citation: N Engl J Med. 2002 May 23;346(21):1616-22
references.pmid: 12023993
references.citation: J Clin Oncol. 2007 Apr 10;25(11):1329-33
references.pmid: 17416853
references.citation: Sociol Health Illn. 2003 Nov;25(7):838-65
references.pmid: 19774749
references.citation: N Engl J Med. 1999 Jul 1;341(1):28-37
references.pmid: 10387940
references.citation: J Womens Health. 1997 Jun;6(3):317-27
references.pmid: 9201666
references.citation: Am J Med Genet A. 2003 Jun 15;119A(3):340-7
references.pmid: 12784302
references.citation: Mil Med. 2002 Feb;167(2):93-8
references.pmid: 11873549
references.citation: Genet Test. 2004 Summer;8(2):148-56
references.pmid: 15345112
references.citation: Cell. 2002 Jan 25;108(2):171-82
references.pmid: 11832208
references.citation: N Engl J Med. 2004 Jul 29;351(5):427-37
references.pmid: 15282350
references.citation: N Engl J Med. 2003 Jun 5;348(23):2339-47
references.pmid: 12788999
references.citation: Res Theory Nurs Pract. 2003 Winter;17(4):339-52
references.pmid: 14960000
references.citation: Psychooncology. 2000 Nov-Dec;9(6):496-503
references.pmid: 11180584
references.citation: J Genet Couns. 2009 Apr;18(2):147-59
references.pmid: 18979190
references.citation: J Genet Couns. 2005 Oct;14(5):349-63
references.pmid: 16195942
references.citation: Health Commun. 2006;19(2):115-23
references.pmid: 16548702
references.citation: Psychooncology. 2007 Apr;16(4):320-8
references.pmid: 16909428
references.citation: Psychooncology. 2008 Aug;17(8):756-66
references.pmid: 18613300
references.citation: J Clin Oncol. 2003 Oct 15;21(20):3867-74
references.pmid: 14551306
references.citation: Psychooncology. 2008 Aug;17(8):797-803
references.pmid: 18646247
references.citation: Am J Med Genet C Semin Med Genet. 2003 May 15;119C(1):78-86
references.pmid: 12704641
references.citation: J Med Ethics. 2003 Apr;29(2):74-9; discussion 80-3
references.pmid: 12672886
references.citation: J Natl Cancer Inst Monogr. 2005;(34):83-6
references.pmid: 15784831
references.citation: Psychooncology. 2009 Oct;18(10):1088-96
references.pmid: 19214961
references.citation: J Nurs Scholarsh. 2005;37(1):18-24
references.pmid: 15813582
references.citation: Nature. 1995 Dec 21-28;378(6559):789-92
references.pmid: 8524414
references.citation: Prev Med. 2000 Jul;31(1):75-80
references.pmid: 10896846
references.citation: Genet Test. 2002 Winter;6(4):291-302
references.pmid: 12537653
references.citation: J Nurs Scholarsh. 2009;41(3):276-83
references.pmid: 19723276
references.citation: J Natl Compr Canc Netw. 2021 Jan 06;19(1):77-102
references.pmid: 33406487
references.citation: Psychooncology. 2005 Dec;14(12):1060-74
references.pmid: 15937976
references.citation: Nurs Ethics. 2000 May;7(3):237-49
references.pmid: 10986947
references.citation: Br J Cancer. 1996 Aug;74(3):482-7
references.pmid: 8695370
references.citation: Ann N Y Acad Sci. 1999 Jun 30;882:42-55; discussion 56-65
references.pmid: 10415885
references.citation: Community Genet. 2004;7(1):15-24
references.pmid: 15475667
references.citation: Science. 1994 Oct 7;266(5182):66-71
references.pmid: 7545954
references.citation: J Genet Couns. 2006 Jun;15(3):149-62
references.pmid: 16724273
references.citation: Nat Med. 2001 May;7(5):552-6
references.pmid: 11329055
references.citation: Science. 2003 Oct 24;302(5645):643-6
references.pmid: 14576434
references.citation: Prev Med. 2004 Apr;38(4):388-402
references.pmid: 15020172