Modulation of inflammation through IL-17 production by gammadelta T cells: mandatory in the mouse, dispensable in humans?
Recent studies suggest that gammadelta T cells are innate IL-17 producers owing to unique features of their developmental program. A key contribution of this subset to T helper 17 responses has been also suggested by numerous physiopathological studies mainly performed in mouse models. In the present review, we will summarize the main features of IL-17-producing gammadelta T cells and highlight the similarities and differences between murine gammadelta T cells and their human counterparts.
Deknuydt
Florence
F
INSERM, U892, Centre de Recherche en Cancérologie Nantes-Angers, 44007 Nantes, France.
Scotet
Emmanuel
E
Bonneville
Marc
M
D000818:Animals; D015703:Antigens, CD / Q000096:biosynthesis; D004195:Disease Models, Animal; D006801:Humans; D007111:Immunity, Cellular; D007239:Infections / Q000276:immunology; D018836:Inflammation Mediators / Q000378:metabolism; D020381:Interleukin-17 / Q000096:biosynthesis* / Q000235:genetics; D051379:Mice; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000378:metabolism*; D037182:T-Cell Antigen Receptor Specificity; D016176:T-Lymphocyte Subsets / Q000378:metabolism* / Q000473:pathology
D015703:Antigens, CD; D018836:Inflammation Mediators; D020381:Interleukin-17; D016692:Receptors, Antigen, T-Cell, gamma-delta