Increased serum fibronectin levels in patients with hemorrhagic fever with renal syndrome.
BACKGROUND
In view of the role of fibronectin in adhesion, signal transduction pathways and the infectious disease process, changes in serum fibronectin levels may influence disease evolution and severity in patients with hemorrhagic fever with renal syndrome (HFRS).


METHODS
The levels of fibronectin were measured in serum samples from 112 patients with HFRS at various phases, and 30 healthy individuals were monitored as controls.


RESULTS
The serum levels of fibronectin in patients with HFRS at all clinical phases were higher than those in the controls, with the levels of patients at the fever, oliguric and polyuric phases of disease significantly different from controls (P < 0.01). The serum fibronectin concentration in the patients with more severe clinical disease types was higher than that in those with milder types. The serum fibronectin level in the more severe patient group was significantly higher than that in milder patient group at the oliguric phase (P < 0.05).


CONCLUSIONS
Serum fibronectin concentration in patients with HFRS was increased and associated with disease phases and severity, suggesting the value of detection of fibronectin levels for evaluating HFRS disease progression and severity.
Han
Qunying
Q
Department of Infectious Diseases, First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, 710061 Xi'an, Shaanxi, China.
Kang
Wen
W
Zhang
Lei
L
Lou
Sai
S
Zhao
Qianzi
Q
Liu
Zhengwen
Z
D000328:Adult; D016022:Case-Control Studies; D018450:Disease Progression; D005260:Female; D005334:Fever / Q000097:blood / Q000209:etiology; D005353:Fibronectins / Q000097:blood*; D018063:Hantaan virus; D006480:Hemorrhagic Fever with Renal Syndrome / Q000097:blood* / Q000150:complications; D006801:Humans; D007022:Hypotension / Q000097:blood / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009846:Oliguria / Q000097:blood / Q000209:etiology; D011141:Polyuria / Q000097:blood / Q000209:etiology; D012720:Severity of Illness Index
D005353:Fibronectins
Arch Pathol Lab Med. 2003 Jan;127(1):30-5
12521363
Prog Hemost Thromb. 1980;5:111-51
6999530
Zhonghua Yi Xue Za Zhi. 1987 May;67(5):253-5
2888523
Virus Res. 1994 Feb;31(2):219-33
7909976
J Infect Dis. 1981 Jan;143(1):15-21
6111576
Ann Surg. 1983 Mar;197(3):310-7
6830338
Emerg Infect Dis. 1997 Apr-Jun;3(2):95-104
9204290
Int J Biochem Cell Biol. 1997 Jul;29(7):939-43
9375374
Blood. 2003 Aug 15;102(4):1405-13
12702510
Blood. 2006 May 1;107(9):3555-63
16391013
Clin Exp Med. 2009 Dec;9(4):297-301
19408099
J Allergy Clin Immunol. 1994 Sep;94(3 Pt 2):625-8
8083471
Microbes Infect. 2001 Nov;3(13):1129-44
11709294
Int J Infect Dis. 2004 Jul;8(4):236-43
15234328
Thromb Res. 2002 Jan 1;105(1):37-41
11864705
Ren Fail. 1997 Jan;19(1):1-14
9044447
J Med Virol. 2008 Oct;80(10):1799-803
18712840
Rev Infect Dis. 1991 Jan-Feb;13(1):97-107
1673261
Clin Diagn Lab Immunol. 1994 May;1(3):269-72
7496961
J Infect Dis. 1986 Sep;154(3):394-8
2874178
Annu Rev Med. 1999;50:531-45
10073292
Arterioscler Thromb Vasc Biol. 2006 Jun;26(6):1193-5
16709950
J Pathol. 1995 Jun;176(2):191-9
7636629
Chin Med J (Engl). 1994 Jun;107(6):444-9
7956485
J Clin Invest. 1997 Aug 1;100(3):693-704
9239418
J Infect Dis. 1978 Mar;137(3):298-308
24670
Int Immunol. 1995 Feb;7(2):251-8
7734420
J Cell Biol. 1998 Oct 5;143(1):241-52
9763435
Mol Immunol. 2002 Jun;38(15):1101-11
12044777