Role of Glutathione monoester on age-related neurochemical alterations in rat brain.
It is quite apparent that the incidence of neurodegenerative diseases in both men and women increases in a logarithmic fashion with age and begins to rise much more rapidly after the age of 60. Brain aging is accompanied by structural and functional changes at cellular and tissue levels such as increase in free radical generation, lowered antioxidant defenses, decrease in number of neurons, decrease in the activities of enzymes, (g) decrease in impulse transmission. The present study was aimed to assess the neuromodulatory role of Glutathione monoester (GME) when administered intraperitoneally (12 mg/kg body weight) for 20 days on acetylcholine esterase (AchE) activity, levels of neurotransmitters such as dopamine, serotonin, norepinephrine and rotorod behavioral analysis in discrete brain regions of young and aged male albino Wistar rats. Age-related decrease (p<0.05) in acetylcholine esterase activity, neurotransmitter levels and also decrease in sensorimotor performance was observed. GME administration was effective in restoring these neuronal parameters in aged rat brain regions. Thus GME act as a neuromodulator in discrete brain regions of aged rats.
Murali
Ganesan
G
Department of Medical Biochemistry, Dr ALM Postgraduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai 600 113, India. murali_ganesan@rediffmail.com
Dhivya
Sugumar
S
Rasappan
Periannan
P
D000110:Acetylcholinesterase / Q000378:metabolism; D000375:Aging / Q000502:physiology*; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry; D004952:Esters / Q000378:metabolism*; D005260:Female; D005978:Glutathione / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D018377:Neurotransmitter Agents / Q000737:chemistry / Q000378:metabolism; D018384:Oxidative Stress; D051381:Rats; D017208:Rats, Wistar; D045442:Rotarod Performance Test
D004952:Esters; D018377:Neurotransmitter Agents; D000110:Acetylcholinesterase; D005978:Glutathione