Epigenomics in psychiatry.
It is not known whether and how epigenetic factors contribute to the pathophysiology of mental disorders. As possible mechanisms, epimutations during embryogenesis, epigenetic memory of environmental effects, and the role of epigenetic gene regulation in the action mechanisms of treatment may be considered. To date, detection of DNA methylation differences between twins discordant for mental disorders, and DNA methylation differences in candidate genes in the postmortem brains between patients with mental disorders and control subjects have been reported. More recently, several findings of epigenomic studies using genome-wide DNA methylation analysis have been reported. Further studies using this comprehensive analysis will provide insight into the role of epigenetics in mental disorders.
Kato
Tadafumi
T
Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako, Japan. kato@brain.riken.jp
D004777:Environment; D044127:Epigenesis, Genetic; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D001523:Mental Disorders / Q000188:drug therapy / Q000235:genetics*; D009154:Mutation