LRRC19, a novel member of the leucine-rich repeat protein family, activates NF-kappaB and induces expression of proinflammatory cytokines.
We have identified a new functional transmembrane receptor, LRRC19 (leucine-rich repeat containing 19), that belongs to the LRR protein family. LRRC19's central core has four analogous LRR repeating modules in a juxtaposed array and a casein kinase (CK2) phosphorylation site in the cytoplasmic domain. LRRC19 mRNA was found in the kidney, spleen and intestine of adult mice using both RT-PCR and in situ hybridization. LRRC19 does not contain a cytoplasmic Toll/IL-1 receptor (TIR) domain but was able to activate NF-kappaB and induce production of proinflammatory cytokines. LRRC19 shares a close evolutionary relationship with multiple Toll-like receptors (TLRs), especially TLR3. Importantly, the TLR3 ligand, as well as other TLR ligands, significantly promoted the expression of proinflammatory cytokines and the activation of NF-kappaB by LRRC19. Thus, LRRC19 may play an important role in inducing innate immune responses in certain tissues such as the kidney.
Chai
Limin
L
Department of Immunology, Nankai University School of Medicine, Nankai University, Tianjin 300071, PR China.
Dai
Lingyun
L
Che
Yongzhe
Y
Xu
Jie
J
Liu
Guojing
G
Zhang
Zhujun
Z
Yang
Rongcun
R
D000595:Amino Acid Sequence; D000818:Animals; D002460:Cell Line; D003001:Cloning, Molecular; D016207:Cytokines / Q000096:biosynthesis*; D006801:Humans; D007113:Immunity, Innate; D007668:Kidney / Q000276:immunology*; D051379:Mice; D008969:Molecular Sequence Data; D016328:NF-kappa B / Q000378:metabolism*; D010802:Phylogeny; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D014018:Tissue Distribution; D051196:Toll-Like Receptor 3 / Q000235:genetics / Q000378:metabolism
D016207:Cytokines; C544174:LRRC19 protein, human; C544175:LRRC19 protein, mouse; D016328:NF-kappa B; D011956:Receptors, Cell Surface; D051196:Toll-Like Receptor 3