A case of epidermolysis bullosa acquisita with clinical features of Brunsting-Perry pemphigoid showing an excellent response to colchicine.
BACKGROUND
Brunsting-Perry pemphigoid is a rare subepidermal blistering disease characterized by scarring blisters on the head and neck. However, the identity of the responsible autoantigens is still unresolved.


METHODS
We reported a patient with epidermolysis bullosa acquisita who had clinical features typical of Brunsting-Perry pemphigoid and investigated the involved type VII collagen epitopes. The patient was a 65-year-old Japanese woman with a 20-month history of recurrent subepidermal bullae on her head, face, and neck.


RESULTS
Immunoblot studies revealed that the serum of this patient reacted with type VII collagen, specifically with the noncollagenous domain 1 and the triple-helical domain. The patient responded completely to colchicine monotherapy.


CONCLUSIONS
This study was performed on only one case.


CONCLUSIONS
This study suggests that Brunsting-Perry pemphigoid may be a clinical variant of epidermolysis bullosa acquisita.
Tanaka
Noriko
N
Department of Dermatology at Kurume University School of Medicine, Fukuoka, Japan.
Dainichi
Teruki
T
Ohyama
Bungo
B
Yasumoto
Shinichiro
S
Oono
Takashi
T
Iwatsuki
Keiji
K
Elfert
Susanne
S
Fritsch
Anja
A
Bruckner-Tuderman
Leena
L
Hashimoto
Takashi
T
D000368:Aged; D003078:Colchicine / Q000008:administration & dosage*; D024143:Collagen Type VII / Q000276:immunology; D016107:Epidermolysis Bullosa Acquisita / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology*; D000939:Epitopes / Q000276:immunology; D005260:Female; D006801:Humans; D010391:Pemphigoid, Bullous / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology*; D050257:Tubulin Modulators / Q000008:administration & dosage*
D024143:Collagen Type VII; D000939:Epitopes; D050257:Tubulin Modulators; D003078:Colchicine