title: The sequential action of miR156 and miR172 regulates developmental timing in Arabidopsis.
abstract: The transition from the juvenile to the adult phase of shoot development in plants is accompanied by changes in vegetative morphology and an increase in reproductive potential. Here, we describe the regulatory mechanism of this transition. We show that miR156 is necessary and sufficient for the expression of the juvenile phase, and regulates the timing of the juvenile-to-adult transition by coordinating the expression of several pathways that control different aspects of this process. miR156 acts by repressing the expression of functionally distinct SPL transcription factors. miR172 acts downstream of miR156 to promote adult epidermal identity. miR156 regulates the expression of miR172 via SPL9 which, redundantly with SPL10, directly promotes the transcription of miR172b. Thus, like the larval-to-adult transition in Caenorhabditis elegans, the juvenile-to-adult transition in Arabidopsis is mediated by sequentially operating miRNAs. miR156 and miR172 are positively regulated by the transcription factors they target, suggesting that negative feedback loops contribute to the stability of the juvenile and adult phases.
authors.affiliation: Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Gang
authors.initials: G
authors.lastname: Wu
authors.forename: Mee Yeon
authors.initials: MY
authors.lastname: Park
authors.forename: Susan R
authors.initials: SR
authors.lastname: Conway
authors.forename: Jia-Wei
authors.initials: JW
authors.lastname: Wang
authors.forename: Detlef
authors.initials: D
authors.lastname: Weigel
authors.forename: R Scott
authors.initials: RS
authors.lastname: Poethig
mesh_terms: D017360:Arabidopsis / Q000235:genetics / Q000254:growth & development* / Q000378:metabolism*; D029681:Arabidopsis Proteins / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D018506:Gene Expression Regulation, Plant; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D015534:Trans-Activators; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D029681:Arabidopsis Proteins; D035683:MicroRNAs; C543702:Mirn172 microRNA, Arabidopsis; C543703:SPL10 protein, Arabidopsis; C531404:SPL9 protein, Arabidopsis; D015534:Trans-Activators; D014157:Transcription Factors
references.citation: Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5424-9
references.pmid: 19289849
references.citation: Development. 2003 Dec;130(24):6001-12
references.pmid: 14573523
references.citation: Annu Rev Cell Dev Biol. 2002;18:495-513
references.pmid: 12142272
references.citation: Plant Cell. 2003 Nov;15(11):2730-41
references.pmid: 14555699
references.citation: Curr Opin Plant Biol. 2005 Feb;8(1):67-70
references.pmid: 15653402
references.citation: Plant J. 2006 Feb;45(4):616-29
references.pmid: 16441352
references.citation: Science. 2007 Aug 31;317(5842):1220-4
references.pmid: 17761882
references.citation: Cell. 2002 Aug 23;110(4):513-20
references.pmid: 12202040
references.citation: Cell. 2006 May 19;125(4):655-64
references.pmid: 16713560
references.citation: Dev Cell. 2005 Apr;8(4):517-27
references.pmid: 15809034
references.citation: Plant Cell. 1994 Oct;6(10):1343-1355
references.pmid: 12244224
references.citation: Cell. 2005 Dec 2;123(5):819-31
references.pmid: 16325577
references.citation: Development. 2009 Mar;136(6):955-64
references.pmid: 19211679
references.citation: Science. 2004 Mar 26;303(5666):2022-5
references.pmid: 12893888
references.citation: Proc Natl Acad Sci U S A. 2005 Jun 28;102(26):9412-7
references.pmid: 15958531
references.citation: Plant J. 2007 Feb;49(4):683-93
references.pmid: 17217458
references.citation: Trends Plant Sci. 2008 Jan;13(1):4-6
references.pmid: 18178509
references.citation: Plant J. 1997 Aug;12(2):367-77
references.pmid: 9301089
references.citation: Nature. 2000 Feb 24;403(6772):901-6
references.pmid: 10706289
references.citation: Development. 1994 Jul;120(7):1971-81
references.pmid: 7925002
references.citation: Science. 2003 Jul 18;301(5631):334-6
references.pmid: 12869752
references.citation: Genes Dev. 2008 Sep 15;22(18):2535-49
references.pmid: 18794350
references.citation: Gene. 2008 Jul 15;418(1-2):1-8
references.pmid: 18495384
references.citation: Science. 1994 Oct 21;266(5184):436-9
references.pmid: 7939683
references.citation: Genes Dev. 1996 Dec 1;10(23):3018-27
references.pmid: 8957002
references.citation: Trends Plant Sci. 2008 Jul;13(7):343-9
references.pmid: 18502167
references.citation: Development. 1997 Feb;124(3):645-54
references.pmid: 9043079
references.citation: Cell. 2005 Mar 11;120(5):635-47
references.pmid: 15766527
references.citation: Int J Dev Biol. 2005;49(5-6):585-93
references.pmid: 16096967
references.citation: Development. 2006 Sep;133(18):3539-47
references.pmid: 16914499
references.citation: Genes Dev. 2007 Sep 15;21(18):2277-82
references.pmid: 17761811
references.citation: Cell. 1993 Dec 3;75(5):843-54
references.pmid: 8252621
references.citation: Nat Genet. 2007 Aug;39(8):1033-7
references.pmid: 17643101
references.citation: Plant Mol Biol. 2008 May;67(1-2):183-95
references.pmid: 18278578
references.citation: Annu Rev Cell Dev Biol. 1998;14:373-98
references.pmid: 9891788
references.citation: Planta. 2000 Mar;210(4):536-42
references.pmid: 10787046
references.citation: Plant Cell. 2008 May;20(5):1231-43
references.pmid: 18492871
references.citation: Nat Genet. 2007 Apr;39(4):544-9
references.pmid: 17369828
references.citation: Plant Cell. 2007 Sep;19(9):2736-48
references.pmid: 17890372
references.citation: Development. 2005 Sep;132(17):3787-98
references.pmid: 16100088
references.citation: Proc Natl Acad Sci U S A. 2004 Feb 10;101(6):1775-80
references.pmid: 14736918
references.citation: Nat Genet. 2007 Dec;39(12):1517-21
references.pmid: 18026103
references.citation: Plant J. 2007 Sep;51(5):840-9
references.pmid: 17573799
references.citation: Curr Biol. 2007 Jun 5;17(11):R425-34
references.pmid: 17550772