title: Neurophysiology of CSWS-associated cognitive dysfunction.
abstract: The phenomenon of continuous spikes and waves during slow-wave sleep (CSWS) is associated with a number of epileptic syndromes, which share a behavioral phenotype characterized by deterioration of cognitive, behavioral, or sensorimotor functions. Available evidence seems to suggest that spike-wave activity is a result of a complex interaction between cortical and subcortical inhibitory networks and can "per se" produce a transient loss of underlying cortical functions. Syndromes like Landau-Kleffner syndrome, CSWS, and phenomena such as negative myoclonus could share in common--at least at the neurophysiological level--some similarities. Differences in behavioral phenotypes could be explained in term of maturational and genetic differences, as well as by the functional specificity of the involved areas.
authors.affiliation: Wellcome Laboratory for MEG Studies, School of Life and Health Sciences, Aston University, Birmingham, United Kingdom. s.seri@aston.ac.uk
authors.forename: Stefano
authors.initials: S
authors.lastname: Seri
authors.forename: Jade Ndoc
authors.initials: JN
authors.lastname: Thai
authors.forename: Daniela
authors.initials: D
authors.lastname: Brazzo
authors.forename: Francesco
authors.initials: F
authors.lastname: Pisani
authors.forename: Antonella
authors.initials: A
authors.lastname: Cerquiglini
mesh_terms: D017668:Age of Onset; D001303:Auditory Cortex / Q000503:physiopathology; D001307:Auditory Perception / Q000502:physiology; D002540:Cerebral Cortex / Q000503:physiopathology*; D002675:Child, Preschool; D003072:Cognition Disorders / Q000175:diagnosis* / Q000503:physiopathology; D004569:Electroencephalography / Q000706:statistics & numerical data; D004831:Epilepsies, Myoclonic / Q000175:diagnosis / Q000503:physiopathology; D019305:Epilepsy, Rolandic / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D018887:Landau-Kleffner Syndrome / Q000175:diagnosis* / Q000503:physiopathology; D008279:Magnetic Resonance Imaging / Q000706:statistics & numerical data; D015225:Magnetoencephalography / Q000706:statistics & numerical data; D008297:Male; D009433:Neural Inhibition / Q000502:physiology; D009483:Neuropsychological Tests / Q000706:statistics & numerical data*; D010100:Oxygen / Q000097:blood; D010641:Phenotype; D012890:Sleep / Q000502:physiology*
chemical_list: D010100:Oxygen