Comparison of plasma clearance of exogenous creatinine, exo-iohexol, and endo-iohexol over a range of glomerular filtration rates expected in cats.
The study investigated plasma clearance of exogenous creatinine (PECCT), exo-iohexol (PexICT) and endo-iohexol (PenICT) in six healthy cats, four cats with chronic kidney disease (CKD) and six hyperthyroid (HT) cats to assess potential differences in glomerular filtration rate (GFR) measurement over a wide range of GFR values. The PECCT, PexICT and PenICT were performed in a combined protocol. There was a significant difference between PexICT and PenICT and PECCT in healthy cats. Differences between clearance techniques are suggested to be correlated to range in GFRs and should be taken into account when GFR is measured.
van Hoek
Ingrid M
IM
Department of Medicine and Clinical Biology of Small Animals, Faculty of Veterinary Medicine, University of Ghent, Salisburylaan 133, 9820 Merelbeke, Belgium.
Lefebvre
Hervé P
HP
Paepe
Dominique
D
Croubels
Siska
S
Biourge
Vincent
V
Daminet
Sylvie
S
D000704:Analysis of Variance; D000818:Animals; D002371:Cat Diseases / Q000378:metabolism* / Q000532:radiotherapy; D002415:Cats / Q000097:blood*; D003404:Creatinine / Q000493:pharmacokinetics*; D005260:Female; D005919:Glomerular Filtration Rate / Q000662:veterinary*; D006980:Hyperthyroidism / Q000378:metabolism / Q000532:radiotherapy / Q000662:veterinary*; D007455:Iodine / Q000627:therapeutic use; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D007472:Iohexol / Q000493:pharmacokinetics*; D007674:Kidney Diseases / Q000175:diagnosis / Q000662:veterinary*; D008297:Male; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D012016:Reference Values
D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D007472:Iohexol; D007455:Iodine; D003404:Creatinine
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