title: [Investigation of respiratory-dependent movements of pulmonary space-occupying lesions with MRI].
abstract: Parallel imaging and echo sharing techniques have markedly reduced the acquisition times for MRI of large volumes. Dynamic 2 and 3-dimensional data sets of the chest with high temporal resolution (up to 10 images/s with single slice and 2 volume/s) allow an analysis of respiratory motion of the lungs and tumors. Time-resolved 2D series in preselected planes can be used to observe respiratory motion during free breathing or after respiratory commands, e.g. to exclude chest wall invasion by a tumor or for diagnosing impairment of respiratory mechanics. Time-resolved 3D-series (4D-MRI) allow monitoring of the spatial displacement of the lungs and tumors as a whole volume. Present limitations such as an overestimation of tumor size and an underestimation of displacement due to a limited temporal resolution are expected to be overcome with further technical developments. However, 4D-MRI already appears to be the appropriate tool to select patients for motion-adapted radiotherapy. In addition 4D-MRI is available for a broad spectrum of scientific applications, as it allows repeated and prolonged series of measurements without radiation exposure.
authors.affiliation: Klinik für Diagnostische Radiologie, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Arnold-Heller-Str. 9, 24105 Kiel. juergen.biederer@rad.uni-kiel.de
authors.forename: J
authors.initials: J
authors.lastname: Biederer
authors.forename: C
authors.initials: C
authors.lastname: Hintze
authors.forename: M
authors.initials: M
authors.lastname: Fabel
authors.forename: J
authors.initials: J
authors.lastname: Dinkel
mesh_terms: D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008168:Lung / Q000473:pathology*; D008171:Lung Diseases / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D055425:Respiratory-Gated Imaging Techniques / Q000379:methods*
references.citation: Radiologe. 2006 Apr;46(4):260-6
references.pmid: 16317532
references.citation: Int J Radiat Oncol Biol Phys. 2008 Nov 15;72(4):1228-35
references.pmid: 18954717
references.citation: Med Phys. 2006 Oct;33(10):3874-900
references.pmid: 17089851
references.citation: Med Phys. 2007 Feb;34(2):388-99
references.pmid: 17388155
references.citation: Radiologe. 2004 Feb;44(2):152-7
references.pmid: 14991134
references.citation: Radiother Oncol. 2009 Jun;91(3):449-54
references.pmid: 19394712
references.citation: Phys Med Biol. 2006 Jun 7;51(11):2939-52
references.pmid: 16723776
references.citation: Phys Med Biol. 2006 Mar 21;51(6):1393-403
references.pmid: 16510951
references.citation: Magn Reson Med. 1996 Sep;36(3):345-51
references.pmid: 8875403
references.citation: Med Phys. 2005 Feb;32(2):627-34
references.pmid: 15789609
references.citation: Radiologe. 2006 Aug;46(8):703-19; quiz 720
references.pmid: 16896635
references.citation: Phys Med Biol. 2004 May 21;49(10):2053-67
references.pmid: 15214541
references.citation: Rofo. 2005 Aug;177(8):1131-8
references.pmid: 16021546
references.citation: Int J Radiat Oncol Biol Phys. 2007 Dec 1;69(5):1642-9
references.pmid: 18035217
references.citation: Radiother Oncol. 2004 Dec;73 Suppl 2:S68-72
references.pmid: 15971313
references.citation: Radiologe. 2006 Apr;46(4):251-4, 256-9
references.pmid: 16440188
references.citation: Radiother Oncol. 2004 Dec;73(3):349-54
references.pmid: 15588881
references.citation: Invest Radiol. 2005 Mar;40(3):173-9
references.pmid: 15714092
references.citation: Phys Med Biol. 2006 Sep 7;51(17):4147-69
references.pmid: 16912374
references.citation: Med Phys. 2004 Aug;31(8):2274-83
references.pmid: 15377094
references.citation: Semin Radiat Oncol. 2004 Jan;14(1):65-75
references.pmid: 14752734
references.citation: Eur Radiol. 2006 Sep;16(9):1942-50
references.pmid: 16628438
references.citation: Radiologe. 2006 Apr;46(4):309-16
references.pmid: 16550355
references.citation: Eur J Radiol. 2007 Dec;64(3):345-55
references.pmid: 17900843
references.citation: Med Phys. 2008 Nov;35(11):4974-81
references.pmid: 19070231
references.citation: Int J Radiat Oncol Biol Phys. 2009 Mar 1;73(3):919-26
references.pmid: 19215826
references.citation: Radiology. 2006 Aug;240(2):537-45
references.pmid: 16801367
references.citation: Phys Med Biol. 2007 Sep 21;52(18):N401-15
references.pmid: 17804874
references.citation: Phys Med Biol. 2004 Feb 7;49(3):425-40
references.pmid: 15012011
references.citation: Int J Radiat Oncol Biol Phys. 2004 Jul 15;59(4):952-9
references.pmid: 15234028
references.citation: Phys Med Biol. 2007 Mar 21;52(6):1547-64
references.pmid: 17327648
references.citation: Eur Radiol. 2009 Feb;19(2):391-9
references.pmid: 18777025
references.citation: Med Phys. 2004 Apr;31(4):760-6
references.pmid: 15124993
references.citation: Spine (Phila Pa 1976). 2004 Feb 1;29(3):298-302
references.pmid: 14752353
references.citation: Int J Radiat Oncol Biol Phys. 2004 Oct 1;60(2):613-22
references.pmid: 15380599