[POEMS syndrome with an isolated lytic lesion and glomeruloid hemangiomas: report of one case].
POEMS syndrome (polyneuropathy, organomegaly, endocrine abnormality, M-protein, plasma cell dyscrasia, and skin lesions) is a rare atypical plasma cell dyscrasia with characteristic para neoplastic manifestations. Glomeruloid hemangioma is a typical skin change pathogenetically related with elevated levels of Vascular Endothelial Growth Factor (VEGF). We report a 69 year-old woman that presented cachexia associated with diabetes, hypothyroidism and severe sensitive motor polyneuropathy. Her skin changes included hyper pigmentation, acrocyanosis and glomeruloid hemangioma. The subsequent study revealed a monoclonal gammopathy lambda type; a unique lytic vertebral lesion and a clonal plasma cell proliferation. Treatment with prednisone 0.5 mg/kg and melphalan 0,25 mg/kg in cycles of 4 days every 4 weeks was started, but the patient was lost from follow up.
Chandía
Mauricio
M
Dermatología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile. mchcabas@gmail.com
Salomone
Claudia
C
Bertín
Pablo
P
González
Sergio
S
D000368:Aged; D005260:Female; D018324:Hemangioma, Capillary / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D008159:Lumbar Vertebrae; D010014:Osteolysis / Q000150:complications* / Q000175:diagnosis; D016878:POEMS Syndrome / Q000150:complications* / Q000175:diagnosis; D012878:Skin Neoplasms / Q000150:complications* / Q000175:diagnosis