Characterization of c-Maf transcription factor in normal and neoplastic hematolymphoid tissue and its relevance in plasma cell neoplasia.
c-Maf, a leucine zipper-containing transcription factor, is involved in the t(14;16)(q32;q23) translocation found in 5% of myelomas. A causal role for c-Maf in myeloma pathogenesis has been proposed, but data on c-Maf protein expression are lacking. We therefore studied the expression of c-Maf protein by immunohistochemical analysis in myelomas and in a wide variety of hematopoietic tissue. c-Maf protein was detected in a small minority (4.3%) of myelomas, including a t(14;16)(q32;q22-23)/IgH-Maf+ case, suggesting that c-Maf protein is not expressed in the absence of c-Maf rearrangement. In contrast, c-Maf was strongly expressed in hairy cell leukemia (4/4) and in a significant proportion of T-cell (24/42 [57%]) and NK/T-cell (49/97 [51%]) lymphomas, which is in keeping with prior gene expression profiling and transgenic mouse studies. Up-regulation of c-Maf protein occurs in a small subset of myelomas, in hairy cell leukemia, and in T- and NK-cell neoplasms. Its detection may be of particular value in the differential diagnosis of small cell lymphomas.
Natkunam
Yasodha
Y
Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Tedoldi
Sara
S
Paterson
Jennifer C
JC
Zhao
Shuchun
S
Rodriguez-Justo
Manuel
M
Beck
Andrew H
AH
Siebert
Reiner
R
Mason
David Y
DY
Marafioti
Teresa
T
D014408:Biomarkers, Tumor / Q000032:analysis*; D015153:Blotting, Western; D015870:Gene Expression; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D008223:Lymphoma / Q000235:genetics / Q000378:metabolism*; D009101:Multiple Myeloma / Q000235:genetics / Q000378:metabolism*; D014066:Palatine Tonsil / Q000378:metabolism; D051257:Proto-Oncogene Proteins c-maf / Q000096:biosynthesis*
D014408:Biomarkers, Tumor; C495607:MAF protein, human; D051257:Proto-Oncogene Proteins c-maf
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