title: Development of multiple-layer polymeric particles for targeted and controlled drug delivery.
abstract: The purpose of this work was to develop multilayered particles consisting of a magnetic core and two encompassing shells made up of poly(N-isopropylacrylamide) (PNIPAAm) and poly(D,L-lactide-co-glycolide) (PLGA) for targeted and controlled drug delivery. Transmission electron microscopy confirmed that multilayered particles were obtained with PNIPAAm magnetic nanoparticles embedded within the PLGA shell. Factorial analysis studies also showed that the particle size was inversely proportional to the surfactant concentration and sonication power and directly proportional to the PLGA concentration. Drug-release results demonstrated that these multilayer particles produced an initial burst release and a subsequent sustained release of both bovine serum albumin (BSA) and curcumin loaded into the core and shell of the particle, respectively. BSA release was also affected by changes in temperature. In conclusion, our results indicate that the multilayered magnetic particles could be synthesized and used for targeted and controlled delivery of multiple drugs with different release mechanisms.
  
  
  BACKGROUND
  Authors demonstrate the synthesis of multilayered particles consisting of a magnetic core and two encompassing shells made up of poly (N-isopropylacrylamide) (PNIPAAm) and poly(D, L-lactide-co-glycolide) (PLGA) for targeted and controlled drug delivery. The presented results indicate successful synthesis and application for targeted and controlled delivery of multiple drugs with different release mechanisms.
authors.affiliation: Biomedical Engineering Program, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA.
authors.forename: Bhanuprasanth
authors.initials: B
authors.lastname: Koppolu
authors.forename: Maham
authors.initials: M
authors.lastname: Rahimi
authors.forename: Sivaniarvindpriya
authors.initials: S
authors.lastname: Nattama
authors.forename: Aniket
authors.initials: A
authors.lastname: Wadajkar
authors.forename: Kytai Truong
authors.initials: KT
authors.lastname: Nguyen
mesh_terms: D000178:Acrylamides / Q000737:chemistry*; D000180:Acrylic Resins; D003692:Delayed-Action Preparations / Q000737:chemistry*; D004058:Diffusion; D016503:Drug Delivery Systems / Q000379:methods*; D019344:Lactic Acid / Q000737:chemistry*; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry*; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers / Q000737:chemistry*
chemical_list: D000178:Acrylamides; D000180:Acrylic Resins; D003692:Delayed-Action Preparations; D011108:Polymers; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; C052970:poly-N-isopropylacrylamide; D011100:Polyglycolic Acid; D019344:Lactic Acid
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