title: PCI complexes: Beyond the proteasome, CSN, and eIF3 Troika.
abstract: The bipartite PCI domain serves as the principal scaffold for proteasome lid, CSN, and eIF3, complexes that influence protein life span. PCI domains are also found in newly identified complexes directing nucleic acid regulation. The breadth of functions associated with the extended PCI family is a factor of shared subunits, among them a common factor Sem1/DSS1 that facilitates complex assembly.
authors.affiliation: Department of Biology, Haifa University at Oranim, Tivon, Israel. elahpic@research.haifa.ac.il
authors.forename: Elah
authors.initials: E
authors.lastname: Pick
authors.forename: Kay
authors.initials: K
authors.lastname: Hofmann
authors.forename: Michael H
authors.initials: MH
authors.lastname: Glickman
mesh_terms: D000075686:COP9 Signalosome Complex; D039621:Eukaryotic Initiation Factor-3 / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D008954:Models, Biological; D046912:Multiprotein Complexes / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D010447:Peptide Hydrolases / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D046988:Proteasome Endopeptidase Complex / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D017434:Protein Structure, Tertiary; D021122:Protein Subunits / Q000737:chemistry / Q000145:classification / Q000502:physiology; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism / Q000502:physiology
chemical_list: D039621:Eukaryotic Initiation Factor-3; D046912:Multiprotein Complexes; D021122:Protein Subunits; C117424:SEM1 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; D010447:Peptide Hydrolases; D000075686:COP9 Signalosome Complex; D046988:Proteasome Endopeptidase Complex