[Acute pancreatitis and primary hyperparathyroidism: a multicentric study by the Francophone Association of Endocrine Surgeons].
BACKGROUND
Primary hyperparathyroidism is an unusual cause of acute pancreatitis. The aim of this study was to analyse data from multiple centers concerning patients with primary hyperparathyroidism and associated acute pancreatitis and to analyze potential predictive factors.


METHODS
In this retrospective multicentric study, 19 patients were identified (Group A) with the associated diagnoses of acute pancreatitis and primary hyperparathyroidism. Their clinical data was compared to that of a control group of 65 patients (group B) with primary hyperparathyroidism without acute pancreatitis.


RESULTS
Age, parathormone levels and pathology (uni/multiglandular disease) were similar between the two groups. The mean plasma calcium level was significantly higher in group A (12.64 mg/100ml) than in group B patients without pancreatitis (11.28 mg/100ml) (p<0.0001).


CONCLUSIONS
This study confirms the causal relationship between primary hyperparathyroidism and acute pancreatitis. The degree of hypercalcemia may play an important role in this association. Calcium levels should be measured in all patients with acute pancreatitis.
Curto
C
C
Clinique de chirurgie digestive et endocrinienne, IMAD, Hôtel-Dieu, 44093 Nantes cedex 01, France.
Caillard
C
C
Desurmont
T
T
Sebag
F
F
Brunaud
L
L
Kraimps
J-L
JL
Hamy
A
A
Mathonnet
M
M
Bresler
L
L
Henry
J-F
JF
Mirallié
E
E
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005602:France; D006801:Humans; D006961:Hyperparathyroidism / Q000150:complications* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000209:etiology* / Q000628:therapy; D012189:Retrospective Studies; D055815:Young Adult