title: Fabrication of cesium-137 brachytherapy sources using vitrification technology.
abstract: 137Cs source in solid matrix encapsulated in stainless-steel at MBq (mCi) levels are widely used as brachytherapy sources for the treatment of carcinoma of cervix uteri. This article describes the large-scale preparation of such sources. The process of fabrication includes vitrification of 137Cs-sodium borosilicate glass, its transformation into spheres of 5-6 mm diameter, casting of glass spheres into a cylinder of 1.5 mm (varphi) x 80 mm (l) in a platinum mould, cutting of the moulds into 5-mm-long pieces, silver coating on the sources, and finally, encapsulation in stainless steel capsules. Development of safety precautions used to trap 137Cs escaping during borosilicate glass preparation is also described. The leach rates of the radioactive sources prepared by the above technology were within permissible limits, and the sources could be used for encapsulation in stainless steel capsules and supplied for brachytherapy applications. This development was aimed at promoting the potential utility of 137Cs-brachytherapy sources in the country and reducing the user's reliance on imported sources. Since its development, more than 1000 such sources have been made by using 4.66 TBq(126 Ci) of 137Cs.
authors.affiliation: Radiopharmaceuticals Division, Bhabha Atomic Research Center, Mumbai, India. adash@barc.gov.in
authors.forename: Ashutosh
authors.initials: A
authors.lastname: Dash
authors.forename: R N
authors.initials: RN
authors.lastname: Varma
authors.forename: Ramu
authors.initials: R
authors.lastname: Ram
authors.forename: S K
authors.initials: SK
authors.lastname: Saxena
authors.forename: A R
authors.initials: AR
authors.lastname: Mathakar
authors.forename: B G
authors.initials: BG
authors.lastname: Avhad
authors.forename: K V S
authors.initials: KV
authors.lastname: Sastry
authors.forename: P R
authors.initials: PR
authors.lastname: Sangurdekar
authors.forename: Meera
authors.initials: M
authors.lastname: Venkatesh
mesh_terms: D001918:Brachytherapy / Q000379:methods*; D002588:Cesium Radioisotopes / Q000008:administration & dosage / Q000737:chemistry*; D005260:Female; D005898:Glass / Q000737:chemistry; D006801:Humans; D011854:Radiochemistry / Q000295:instrumentation / Q000379:methods*; D011879:Radiotherapy Dosage; D002583:Uterine Cervical Neoplasms / Q000532:radiotherapy
chemical_list: D002588:Cesium Radioisotopes