Delayed effect of hypotensive drugs on blood pressure and structure of the myocardium in hypertensive ISIAH rats during chronic stress.
Administration of antihypertensive drugs alpha(1)-adrenoceptor antagonist and Ca(2+) channel blocker during early ontogeny had various delayed effects on blood pressure in ISIAH rats with inherited stress-induced arterial hypertension under resting conditions and chronic stress. The drugs did not prevent the development of myocardial hypertrophy. Chronic stress had little effect on myocardial structure in adult animals.
Korostyshevskaya
I M
IM
Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia. kor@physiol.ru
Maksimov
V F
VF
Markel
A L
AL
Shmerling
M D
MD
Buzueva
I I
II
Filushina
E E
EE
Jacobson
G S
GS
D058668:Adrenergic alpha-1 Receptor Antagonists; D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D002121:Calcium Channel Blockers / Q000494:pharmacology; D006332:Cardiomegaly / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D002908:Chronic Disease; D006321:Heart / Q000187:drug effects*; D008297:Male; D009206:Myocardium / Q000473:pathology*; D051381:Rats; D011919:Rats, Inbred Strains; D013315:Stress, Psychological / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D013997:Time Factors
D058668:Adrenergic alpha-1 Receptor Antagonists; D000317:Adrenergic alpha-Antagonists; D000959:Antihypertensive Agents; D002121:Calcium Channel Blockers