title: Synthesis and biological evaluation of asymmetric gramicidin S analogues containing modified D-phenylalanine residues.
abstract: The synthesis of new analogues of the cationic antimicrobial peptide gramicidin S, having a modified D-phenylalanine residue, their antibacterial properties against several gram positive and negative strains, as well as their hemolytic activity is reported.
authors.affiliation: Bio-Organic Synthesis, Leiden Institute of Chemistry, University of Leiden, Leiden, The Netherlands.
authors.forename: Matthijs
authors.initials: M
authors.lastname: van der Knaap
authors.forename: Eefje
authors.initials: E
authors.lastname: Engels
authors.forename: Henk J
authors.initials: HJ
authors.lastname: Busscher
authors.forename: José M
authors.initials: JM
authors.lastname: Otero
authors.forename: Antonio L
authors.initials: AL
authors.lastname: Llamas-Saiz
authors.forename: Mark J
authors.initials: MJ
authors.lastname: van Raaij
authors.forename: Roos H
authors.initials: RH
authors.lastname: Mars-Groenendijk
authors.forename: Daan
authors.initials: D
authors.lastname: Noort
authors.forename: Gijsbert A
authors.initials: GA
authors.lastname: van der Marel
authors.forename: Herman S
authors.initials: HS
authors.lastname: Overkleeft
authors.forename: Mark
authors.initials: M
authors.lastname: Overhand
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004912:Erythrocytes / Q000187:drug effects; D006096:Gramicidin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D006461:Hemolysis; D006801:Humans; D008826:Microbial Sensitivity Tests; D010649:Phenylalanine / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D006096:Gramicidin; D010649:Phenylalanine