[Obesity and coronary heart disease: the mechanism of atherogenic impact].
The epidemic of obesity and overweight leads to many diseases including cardiovascular disease. Having an influence on function and heart structure, obesity and overweight are in connection with coronary heart disease, heart failure and sudden heart death. Cardiomyopathy in obesity (adipositas cordis) appears due to accumulation of adipose tissue between the heart muscle fibers and degeneration of myocites. The degeneration of myocardial could be due to lipotoxicity of free fatty acids in adipose tissue. The left ventricle hypertrophy, diastolic dysfunction, increasing blood volume, ejection fraction lead to heart failure. Obesity is low inflammation state with increased adipocitokine production from truncal adipose tissue which causes endothelial dysfunction and insulin resistance. Adipocitokines include leptin, adiponectin, resistin, visfatin, RBP 4 (retinol binding protein), angiotenzinogen, TNF alpha (tumor necrosis factor), PAI 1 (plazminogen activator inhibitor), fatty acids, sex steroids and different growth factors. Adipocitokines act synergistically or competitively with insulin, that explaining their impact on insulin resistance. Inflammatory citokines from adipose tissue could have influence on blood vessels endothelial function without their increase in plasma concentrations.
Micić
Dragan
D
Klinicki centar Srbije, Beograd, Institut za endokrinologiju, dijabetes i bolesti metabolizma.
Polovina
Snezana
S
D054392:Adipokines / Q000502:physiology*; D050197:Atherosclerosis / Q000209:etiology / Q000503:physiopathology*; D006801:Humans; D007333:Insulin Resistance; D009765:Obesity / Q000150:complications / Q000503:physiopathology*
D054392:Adipokines