Neurohumoral mechanisms in deoxycorticosterone acetate (DOCA)-salt hypertension in rats.
This brief review describes the role of neural and non-neural mechanisms during different phases of deoxycorticosterone acetate (DOCA)-salt hypertension. There are contradictory data for and against a role of the sympathetic nervous system and neurohumoral agents, including endothelin and vasopressin. Elucidating the factors responsible for DOCA-salt hypertension will be helpful in understanding the causes of hypertension resulting from hypervolaemia, hyperaldosteronism and high salt intake.
Yemane
Henok
H
Department of Pharmacological and Physiological Science, St Louis University School of Medicine, 1402 South Grand Boulevard, St Louis, MO 63104, USA.
Busauskas
Marius
M
Burris
Sarah K
SK
Knuepfer
Mark M
MM
D000818:Animals; D003900:Desoxycorticosterone / Q000633:toxicity*; D004195:Disease Models, Animal; D006801:Humans; D006973:Hypertension / Q000139:chemically induced* / Q000378:metabolism*; D018377:Neurotransmitter Agents / Q000378:metabolism*; D051381:Rats; D017673:Sodium Chloride, Dietary / Q000009:adverse effects
D018377:Neurotransmitter Agents; D017673:Sodium Chloride, Dietary; D003900:Desoxycorticosterone