title: Syndrome of inappropriate antidiuretic hormone secretion associated with congenital hydrocephalus in a dog.
abstract: A 13-month-old, male bichon frise was examined for the investigation of intermittent seizures, ataxia, abnormal behavior, polyuria, and polydipsia. At presentation, clinical and neurological examinations were unremarkable with the exception of mild truncal ataxia and a domed skull. Severe hyponatremia and hypoosmolality were identified, and following diagnostic testing a diagnosis of the syndrome of inappropriate antidiuretic hormone secretion (SIADH) was made. Magnetic resonance imaging revealed changes consistent with severe hydrocephalus. Water restriction resulted in increased serum osmolality and a reduction in severity of clinical signs. The current case report documents SIADH associated with hydrocephalus in a dog. Structural brain disease should be excluded before a diagnosis of idiopathic SIADH is made.
authors.affiliation: Unit of Small Animal Clinical Studies, School of Agriculture, Food Science, and Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland.
authors.forename: Robert E
authors.initials: RE
authors.lastname: Shiel
authors.forename: Manuel
authors.initials: M
authors.lastname: Pinilla
authors.forename: Carmel T
authors.initials: CT
authors.lastname: Mooney
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000097:blood / Q000175:diagnosis*; D004285:Dogs; D004326:Drinking; D006849:Hydrocephalus / Q000097:blood / Q000175:diagnosis / Q000662:veterinary*; D007177:Inappropriate ADH Syndrome / Q000097:blood / Q000175:diagnosis / Q000662:veterinary*; D008279:Magnetic Resonance Imaging / Q000662:veterinary; D008297:Male; D009994:Osmolar Concentration; D012720:Severity of Illness Index; D013577:Syndrome; D014667:Vasopressins / Q000378:metabolism*
chemical_list: D014667:Vasopressins