title: [Prognosis of rectal cancer patients after total mesorectal excision].
abstract: OBJECTIVE
  Total mesorectal excision (TME) can reduce local recurrence and improve prognosis of rectal cancer. This study was to analyze the clinicopathologic characteristics of rectal cancer, and explore the prognosis factors of rectal cancer after radical TME.
  
  
  METHODS
  From 1990 to 2003, 1056 rectal cancer patients had received radical TME. The impacts of 20 clinicopathologic factors on the prognosis were analyzed with univariate and multivariate method.
  
  
  RESULTS
  The 3-, 5-, and 10-year overall survival rates were 84.9% (95% CI, 83.8%-86.0%), 73.8% (95% CI, 72.4%-75.2%), and 65.1% (95% CI, 63.4%-66.8%), respectively. Univariate analysis showed that preoperative serum carcinoembryonic antigen (CEA) and CA19-9 levels, tumor gross type, pathologic type, pathologic grade, preoperative bowel obstruction or bowel perforation, T stage, N stage, and first treatment era were associated with the prognosis of rectal cancer. Multivariate analysis showed that N stage, histological type, surgical procedures, and T stage were independent prognostic factors.
  
  
  CONCLUSIONS
  N stage, histological type, surgical procedures, and T stage are independent prognostic factors for rectal cancer patients who received radical TME.
authors.affiliation: State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, 510060, PR China. panzhzh@mail.sysu.edu.cn
authors.forename: Zhi-Zhong
authors.initials: ZZ
authors.lastname: Pan
authors.forename: Pei-Rong
authors.initials: PR
authors.lastname: Ding
authors.forename: De-Sen
authors.initials: DS
authors.lastname: Wan
authors.forename: Li-Ren
authors.initials: LR
authors.lastname: Li
authors.forename: Xiao-Jun
authors.initials: XJ
authors.lastname: Wu
authors.forename: Zhen-Hai
authors.initials: ZH
authors.lastname: Lu
authors.forename: Ling-Heng
authors.initials: LH
authors.lastname: Kong
authors.forename: Jun-Zhong
authors.initials: JZ
authors.lastname: Lin
authors.forename: Zhong-Guo
authors.initials: ZG
authors.lastname: Zhou
mesh_terms: D000230:Adenocarcinoma / Q000097:blood / Q000150:complications / Q000473:pathology / Q000601:surgery*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018395:CA-19-9 Antigen / Q000097:blood; D002272:Carcinoembryonic Antigen / Q000097:blood; D013505:Digestive System Surgical Procedures / Q000379:methods*; D005260:Female; D006801:Humans; D007415:Intestinal Obstruction / Q000150:complications; D007416:Intestinal Perforation / Q000150:complications; D008207:Lymphatic Metastasis; D008297:Male; D008643:Mesentery / Q000601:surgery*; D008875:Middle Aged; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D012004:Rectal Neoplasms / Q000097:blood / Q000150:complications / Q000473:pathology / Q000601:surgery*; D012189:Retrospective Studies; D015996:Survival Rate; D055815:Young Adult
chemical_list: D018395:CA-19-9 Antigen; D002272:Carcinoembryonic Antigen