title: [The epidemiology of cleft lip and palate over the period 1990-2004 in Asturias].
abstract: BACKGROUND
  Cleft lip and palate (oral clefts) are the most common congenital facial defects.
  
  
  OBJECTIVE
  To assess the prevalence of oral clefts and to describe the associated malformations in a geographically defined population.
  
  
  METHODS
  Data from the Asturias Registry of Congenital Defects were used to investigate the epidemiology of congenital facial clefts over the period 1990-2004 among the 103,452 births in the region. The results were also compared with data from EUROCAT and other Spanish registries.
  
  
  RESULTS
  Out of 145 oral clefts recorded, cleft lip was 26.9%, cleft lip and palate 28.3% and cleft palate 44.8%. Total prevalence of oral clefts was 14.4 per 10,000 births. Other associated defects were found in 18.6% of the total cases, with skeletal, cardiovascular and central nervous systems being the the most common anomalies. Syndromes or sequences were found in 22% of clefts. A prenatal diagnosis was made in 12.4%.
  
  
  CONCLUSIONS
  The prevalence of oral clefts in Asturias over this period fell within the range reported for other European registries. An exhaustive prenatal ultrasound and examination of the affected newborns to look for other malformations should be considered in infants with clefts, due to the high association with them.
authors.affiliation: Hospital San Agustín, Avilés, Asturias, España. crdehli@yahoo.es
authors.forename: C
authors.initials: C
authors.lastname: Rodríguez Dehli
authors.forename: C
authors.initials: C
authors.lastname: Mosquera Tenreiro
authors.forename: E
authors.initials: E
authors.lastname: García López
authors.forename: J
authors.initials: J
authors.lastname: Fernández Toral
authors.forename: A
authors.initials: A
authors.lastname: Rodríguez Fernández
authors.forename: I
authors.initials: I
authors.lastname: Riaño Galán
authors.forename: F
authors.initials: F
authors.lastname: Ariza Hevia
mesh_terms: D002971:Cleft Lip / Q000453:epidemiology*; D002972:Cleft Palate / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D015995:Prevalence; D013030:Spain / Q000453:epidemiology; D013997:Time Factors