title: Biomimetic remineralization of resin-bonded acid-etched dentin.
abstract: Degradation of denuded collagen within adhesive resin-infiltrated dentin is a pertinent problem in dentin bonding. A biomimetic remineralization scheme that incorporates non-classic crystallization pathways of fluidic amorphous nanoprecursors and mesoscopic transformation has been successful in remineralizing resin-free, acid-etched dentin, with evidence of intrafibrillar and interfibrillar remineralization. This study tested the hypothesis that biomimetic remineralization provides a means for remineralizing incompletely infiltrated resin-dentin interfaces created by etch-and-rinse adhesives. The remineralization medium consists of a Portland cement/simulated body fluid that includes polyacrylic acid and polyvinylphosphonic acid biomimetic analogs for amorphous calcium phosphate dimension regulation and collagen targeting. Both interfibrillar and intrafibrillar apatites became readily discernible within the hybrid layers after 2-4 months. In addition, intra-resin apatite clusters were deposited within the porosities of the adhesive resin matrices. The biomimetic remineralization scheme provides a proof-of-concept for the adoption of nanotechnology as an alternative strategy to extend the longevity of resin-dentin bonds.
authors.affiliation: Department of Endodontics, School of Dentistry, Medical College of Georgia, Augusta, GA 30912-1129, USA. FTAY@mcg.edu
authors.forename: F R
authors.initials: FR
authors.lastname: Tay
authors.forename: D H
authors.initials: DH
authors.lastname: Pashley
mesh_terms: D000134:Acid Etching, Dental / Q000379:methods*; D000180:Acrylic Resins / Q000737:chemistry; D040761:Biomimetic Materials / Q000627:therapeutic use*; D017438:Bisphenol A-Glycidyl Methacrylate / Q000737:chemistry; D017610:Calcium Compounds / Q000737:chemistry; D002130:Calcium Phosphates / Q000737:chemistry; D002133:Calcium Sulfate / Q000737:chemistry; D003094:Collagen / Q000737:chemistry; D003188:Composite Resins / Q000737:chemistry; D003460:Crystallization; D001840:Dental Bonding; D003738:Dental Cements / Q000737:chemistry; D003764:Dental Materials / Q000737:chemistry; D003804:Dentin / Q000187:drug effects*; D017220:Dentin-Bonding Agents / Q000737:chemistry; D006801:Humans; D008422:Materials Testing; D008689:Methacrylates / Q000737:chemistry; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000737:chemistry; D063065:Organophosphonates / Q000737:chemistry; D010756:Phosphoric Acids / Q000737:chemistry; D011145:Polyvinyls / Q000737:chemistry; D016062:Porosity; D019279:Resin Cements / Q000737:chemistry*; D012464:Saliva, Artificial / Q000737:chemistry; D017640:Silicates / Q000737:chemistry; D014089:Tooth Remineralization / Q000379:methods*
chemical_list: D000180:Acrylic Resins; C103506:Bis-GMA, BPDM, HEMA dental-bonding resin; D017610:Calcium Compounds; D002130:Calcium Phosphates; D003188:Composite Resins; D003738:Dental Cements; D003764:Dental Materials; D017220:Dentin-Bonding Agents; D008689:Methacrylates; D063065:Organophosphonates; D010756:Phosphoric Acids; D011145:Polyvinyls; D019279:Resin Cements; D012464:Saliva, Artificial; D017640:Silicates; C511238:Single Bond Plus; D017438:Bisphenol A-Glycidyl Methacrylate; C006903:carbopol 940; D003094:Collagen; C020243:calcium phosphate; C030242:phosphoric acid; C031293:calcium silicate; D002133:Calcium Sulfate