title: Terretonins E and F, inhibitors of the mitochondrial respiratory chain from the marine-derived fungus Aspergillus insuetus (#).
abstract: Two new meroterpenoids, terretonins E and F (1, 2), together with three known compounds, aurantiamine (3), linoleic acid, and uridine, were isolated as fermentation products of the marine-derived fungus Aspergillus insuetus, which was associated with the sponge Petrosia ficiformis. Structures of all isolates were elucidated employing spectroscopic methods, mainly by two-dimensional NMR techniques. Compounds 1-3 showed activity as inhibitors of the mammalian mitochondrial respiratory chain.
authors.affiliation: Instituto de Biologia Molecular y Celular de Plantas, Ciudad Politecnica de la Innovacion, 46022 Valencia, Spain. mplopez@ceqa.upv.es
authors.forename: M Pilar
authors.initials: MP
authors.lastname: López-Gresa
authors.forename: Nuria
authors.initials: N
authors.lastname: Cabedo
authors.forename: M Carmen
authors.initials: MC
authors.lastname: González-Mas
authors.forename: Maria Letizia
authors.initials: ML
authors.lastname: Ciavatta
authors.forename: Conxita
authors.initials: C
authors.lastname: Avila
authors.forename: Jaime
authors.initials: J
authors.lastname: Primo
mesh_terms: D000818:Animals; D001230:Aspergillus / Q000737:chemistry*; D006801:Humans; D008386:Marine Biology; D008928:Mitochondria / Q000187:drug effects* / Q000201:enzymology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D013729:Terpenes; C543992:terretonin E; C543993:terretonin F