Cyclooxygenase-2 expression in cervical intraepithelial neoplasia.
To evaluate the role of cyclooxygenase (COX)-2 during cervical carcinogenesis, we investigated COX-2 expression in the dysplastic epithelium and stromal cells of cervical intraepithelial neoplasia (CIN). Immunohistochemical analysis with COX-2 antibody was performed on 148 paraffin-embedded tissue specimens of patients who were diagnosed as CIN in our institute. COX-2 expression was evaluated separately in the dysplastic epithelium and stromal cells of CIN. The relationships between COX-2 expression and clinicopathologic variables were examined. For the dysplastic epithelium, COX-2 expression was negative in 137 (92.6%) and positive in 11 (7.4%) specimens. For the stromal cells, COX-2 expression was negative in all specimens. The COX-2 expression in dysplastic epithelium was higher in older (P= 0.038) or postmenopausal (P= 0.025) women. In conclusion, COX-2 expression was observed only in the dysplastic epithelium but not in the stromal cells of CIN. The COX-2 expression in dysplastic epithelium was associated with age and menopausal status.
Kim
Kidong
K
Department of Obstetrics and Gynecology, Korea Institute of Radiological & Medical Sciences, Seoul, Korea.
Jeon
Yong-Tark
YT
Park
In-Ae
IA
Kim
Jae Weon
JW
Park
Noh-Hyun
NH
Kang
Soon-Beom
SB
Lee
Hyo-Pyo
HP
Song
Yong-Sang
YS
D000328:Adult; D051546:Cyclooxygenase 2 / Q000378:metabolism*; D004848:Epithelium / Q000201:enzymology / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D017698:Postmenopause; D017697:Premenopause; D017154:Stromal Cells / Q000201:enzymology / Q000473:pathology; D002583:Uterine Cervical Neoplasms / Q000201:enzymology / Q000473:pathology*; D002578:Uterine Cervical Dysplasia / Q000201:enzymology / Q000473:pathology*
D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human