Predicting progression to glaucoma in ocular hypertensive patients.
OBJECTIVE
To assess the ability of Heidelberg Retina Tomograph (HRT) Moorfields Regression Analysis (MRA) and Glaucoma Probability Score (GPS) classifications at baseline to predict glaucomatous progression in ocular hypertensive eyes.


METHODS
One hundred ninety-eight ocular hypertensive subjects underwent regular HRT and visual field (VF) testing from 1993 to 2001. HRT progression was assessed using linear regression of rim area/time. VF progression was assessed by pointwise linear regression of sensitivity/time. Subjects were classified as progressing or stable at the end of the study period. The relationship between baseline abnormal (outside normal limits combined with borderline classification) MRA and GPS classification and progression status was assessed by odds ratios (ORs).


RESULTS
An abnormal superotemporal MRA was the only classification found to be predictive of HRT progression in isolation (OR 3.05, 1.25-7.47). Abnormal global, superotemporal, superonasal, and temporal MRA classifications were all associated with significant ORs for predicting HRT or VF progression (OR range: 1.77-2.54). Abnormal GPS classifications were not predictive of disease behavior. Combined abnormal GPS and MRA classifications were associated with higher ORs than either classification in isolation.


CONCLUSIONS
Patients with an abnormal MRA and GPS classification at presentation may be at increased risk of HRT or VF change.
Strouthidis
Nicholas G
NG
Glaucoma Research Unit, NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust, UCL Institute of Ophthalmology, London, UK.
Gardiner
Stuart K
SK
Owen
Victoria M F
VM
Zuniga
Claudio
C
Garway-Heath
David F
DF
D000328:Adult; D000368:Aged; D003941:Diagnostic Techniques, Ophthalmological; D018450:Disease Progression; D005901:Glaucoma / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D007429:Intraocular Pressure; D008875:Middle Aged; D009798:Ocular Hypertension / Q000175:diagnosis* / Q000503:physiopathology; D009887:Ophthalmoscopy; D009898:Optic Disk / Q000473:pathology*; D011336:Probability; D011446:Prospective Studies; D012044:Regression Analysis; D012680:Sensitivity and Specificity; D013997:Time Factors; D014054:Tomography; D014786:Vision Disorders / Q000175:diagnosis; D014794:Visual Fields