Selective synthesis of o-acylbenzylphosphonates by insertion reactions of arynes into beta-ketophosphonates.
A mild method for selective synthesis of o-acylbenzylphosphonates has been developed by the reactions of arynes with beta-ketophosphonates. In the presence of CsF and THF, the carbon-carbon sigma-bonds of 2-oxopropylphosphonates were selectively cleaved and added to arynes providing the corresponding 2-acylbenzylphosphonates in moderate to good yields.
Liu
Yi-Lin
YL
Key Laboratory of Chemical Biology & Traditional Chinese Medicine Research (Ministry of Education), Hunan Normal University, Changsha 410081, China.
Liang
Yun
Y
Pi
Shao-Feng
SF
Li
Jin-Heng
JH
D000480:Alkynes / Q000737:chemistry*; D006841:Hydrocarbons, Aromatic / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D063065:Organophosphonates / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism
D000480:Alkynes; D006841:Hydrocarbons, Aromatic; D063065:Organophosphonates