title: Difference of culprit plaque composition between patients with and without pre-infarction angina: an intravascular ultrasound radiofrequency analysis.
abstract: OBJECTIVE
  This study was performed to assess the differences in culprit plaque composition between patients with and without pre-infarction angina (PA) by using spectral analysis of intravascular ultrasound (IVUS) radiofrequency (RF) data.
  
  
  RESULTS
  Of 57 patients consecutively admitted to our institution with acute myocardial infarction, pre-intervention IVUS RF data of culprit plaques were obtained and analysed in 35 patients after percutaneous aspiration thrombectomy. Among the 35 patients, 21 patients had PA. Culprit plaques of patients without PA consisted of a higher percentage of the necrotic core component than those with PA (minimum lumen area [MLA]) site, 21.2+/-8.9% versus 9.9+/-9.8%, p=0.0015; entire culprit lesion, 18.9+/-6.3% versus 12.0+/-9.6%, p=0.023). In contrast, culprit plaques of patients with PA contained a higher percentage of the fibrofatty component than those without PA (MLA site, 21.0+/-12.0% versus 11.5+/-7.6%, p=0.013; entire culprit lesion, 16.8+/-7.9% versus 12.1+/-5.5%, p=0.062). There was no significant difference in quantitative parameters between the patients with and without PA.
  
  
  CONCLUSIONS
  Culprit plaques of patients with PA were different from those without PA. Plaque composition may play an important role in the occurrence of PA.
authors.affiliation: Division of Cardiology, Mitsui Memorial Hospital, Tokyo, Japan.
authors.forename: Yasutomi
authors.initials: Y
authors.lastname: Higashikuni
authors.forename: Kengo
authors.initials: K
authors.lastname: Tanabe
authors.forename: Shuzou
authors.initials: S
authors.lastname: Tanimoto
authors.forename: Jiro
authors.initials: J
authors.lastname: Aoki
authors.forename: Hirosada
authors.initials: H
authors.lastname: Yamamoto
authors.forename: Gaku
authors.initials: G
authors.lastname: Nakazawa
authors.forename: Ruri
authors.initials: R
authors.lastname: Chihara
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Onuma
authors.forename: Shuji
authors.initials: S
authors.lastname: Otsuki
authors.forename: Atsuhiko
authors.initials: A
authors.lastname: Yagishita
authors.forename: Sen
authors.initials: S
authors.lastname: Yachi
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Nakajima
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Hara
mesh_terms: D000368:Aged; D000787:Angina Pectoris / Q000000981:diagnostic imaging* / Q000209:etiology / Q000628:therapy; D015906:Angioplasty, Balloon, Coronary; D003324:Coronary Artery Disease / Q000150:complications / Q000000981:diagnostic imaging* / Q000628:therapy; D005260:Female; D005355:Fibrosis; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging* / Q000209:etiology / Q000628:therapy; D009336:Necrosis; D011237:Predictive Value of Tests; D013396:Suction; D017131:Thrombectomy / Q000379:methods; D018084:Ultrasonography, Interventional