Sirolimus-eluting versus bare-metal stent implantation in patients with ostial lesions.
BACKGROUND
To investigate the efficacy of implantation of sirolimus-eluting stents (SES) in the ostium of coronary arteries.


METHODS
We assigned 96 patients with lesions located in ostias of the coronary circulation to receive a SES or a bare-metal stent (BMS).


RESULTS
At follow-up the late lumen loss was 0.07 mm in the SES versus 1.06 mm in the BMS group (p<0.001); -0.04 mm versus 0.11 mm (p = 0.12) in the neighbour ostium. The rate of target lesion revascularisation was 2% with SES and 39% with BMS (p<0.001), and major adverse cardiac events (MACE) 6% versus 41% (p = 0.001).


CONCLUSIONS
In patients with ostial coronary lesions the angiographic outcome is improved and the long-term MACE rate is low after SES compared with BMS implantation.
Jørgensen
Erik
E
Kelbæk
Henning
H
Kløvgaard
Lene
L
Thuesen
Leif
L
Krusell
Lars R
LR
Bøtker
Hans E
HE
Saunamäki
Kari
K
Lassen
Jens F
JF
Helqvist
Steffen
S
D054058:Acute Coronary Syndrome / Q000473:pathology / Q000628:therapy; D023903:Coronary Restenosis; D003331:Coronary Vessels / Q000473:pathology*; D054855:Drug-Eluting Stents / Q000009:adverse effects; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008670:Metals / Q000009:adverse effects; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic; D020123:Sirolimus / Q000008:administration & dosage*; D015607:Stents / Q000009:adverse effects; D013927:Thrombosis / Q000209:etiology / Q000473:pathology
D008670:Metals; D020123:Sirolimus