Inherited susceptibility to pediatric acute lymphoblastic leukemia.
Although genome-wide analyses have identified somatic alterations contributing to the pathogenesis of pediatric acute lymphoblastic leukemia (ALL), few studies have identified germline variants conferring risk of this disease. Two reports now provide the first genome-wide glimpse into the role of inherited alleles in ALL pathogenesis.
Levine
Ross L
RL
D000483:Alleles; D022762:CCAAT-Enhancer-Binding Proteins / Q000235:genetics; D016022:Case-Control Studies; D002461:Cell Line, Transformed; D002472:Cell Transformation, Viral; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D050676:Core Binding Factor Alpha 2 Subunit / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D055106:Genome-Wide Association Study; D018095:Germ-Line Mutation; D006239:Haplotypes; D004854:Herpesvirus 4, Human / Q000502:physiology; D006801:Humans; D051740:Ikaros Transcription Factor / Q000235:genetics; D015514:Oncogene Proteins, Fusion / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000145:classification / Q000209:etiology* / Q000235:genetics; D012307:Risk Factors; D014157:Transcription Factors / Q000235:genetics; D000097764:ETS Translocation Variant 6 Protein
D022762:CCAAT-Enhancer-Binding Proteins; D050676:Core Binding Factor Alpha 2 Subunit; D004268:DNA-Binding Proteins; D051740:Ikaros Transcription Factor; D015514:Oncogene Proteins, Fusion; D014157:Transcription Factors; C503805:ARID5B protein, human; C497239:IKZF1 protein, human; C102421:TEL-AML1 fusion protein; D000097764:ETS Translocation Variant 6 Protein; C070790:CEBPE protein, human