title: Efficacy of a new formulation of amphotericin B in murine disseminated infections by Candida glabrata or Candida tropicalis.
abstract: Amphotericin B microspheres (M-AMB) are a new, inexpensive formulation of amphotericin B. In this study, we tested the efficacy of this new formulation for treating murine disseminated infections by Candida glabrata or Candida tropicalis. M-AMB showed a similar efficacy to that of amphotericin B deoxycholate and liposomal amphotericin B in the treatment of both disseminated murine infections. Its low toxicity and inexpensive production costs make this formulation potentially attractive for the treatment of fungal infections.
authors.affiliation: Unitat de Microbiologia, Facultat de Medicina, IISPV, Universitat Rovira i Virgili, Carrer Sant Llorenç 21, 43201, Reus, Spain.
authors.forename: Marçal
authors.initials: M
authors.lastname: Mariné
authors.forename: Raquel
authors.initials: R
authors.lastname: Espada
authors.forename: Juan
authors.initials: J
authors.lastname: Torrado
authors.forename: F Javier
authors.initials: FJ
authors.lastname: Pastor
authors.forename: Josep
authors.initials: J
authors.lastname: Guarro
mesh_terms: D000666:Amphotericin B / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use*; D000818:Animals; D000935:Antifungal Agents / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use*; D041221:Candida glabrata / Q000187:drug effects*; D041022:Candida tropicalis / Q000187:drug effects*; D002177:Candidiasis / Q000188:drug therapy* / Q000382:microbiology; D002626:Chemistry, Pharmaceutical; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008863:Microspheres; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B