[Biological characteristics of microorganisms for prognosis of trophic ulcers course].
OBJECTIVE
To substantiate the possibility to use the biological characteristics of microorganism, in particular, factors of its persistence, for assessment of severity of trophic ulcers of lower extremities.


METHODS
Clinical examinations and bacteriological tests of 48 patients aged from 37 to 80 years with trophic ulcer of lower limbs were performed. Antilysozyme, anticomplement, anticarnosine as well as hemolytic activity of isolated microorganisms were assessed.


RESULTS
It was established that microflora of trophic ulcers of lower limbs are diverse and microorganisms were isolated both in monoculture and in associations, with maximal significance of Staphylococcus aureus. Analysis of biological properties of microflora isolated in patients with various courses of trophic ulcers of lower limbs allowed to determine roles of antilysozyme, anticomplement, anticarnosine and hemolytic activities in severity of the illness.


CONCLUSIONS
Performed studies allowed to develop diagnostic models for prediction of severity course of trophic ulcers of lower limbs.
Kartashova
O L
OL
Gandybin
E A
EA
Utkina
T M
TM
Abramzon
O M
OM
Kirgizova
S B
SB
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001426:Bacterial Proteins / Q000378:metabolism; D002336:Carnosine / Q000037:antagonists & inhibitors / Q000378:metabolism; D003169:Complement Inactivator Proteins / Q000378:metabolism; D018450:Disease Progression; D053878:Hemolytic Agents / Q000378:metabolism; D006801:Humans; D007871:Leg Ulcer / Q000209:etiology / Q000382:microbiology* / Q000473:pathology; D035002:Lower Extremity / Q000098:blood supply; D008875:Middle Aged; D009113:Muramidase / Q000037:antagonists & inhibitors / Q000378:metabolism; D013203:Staphylococcal Infections / Q000382:microbiology* / Q000473:pathology; D013211:Staphylococcus aureus / Q000302:isolation & purification / Q000472:pathogenicity*; D014648:Varicose Veins; D014689:Venous Insufficiency / Q000150:complications; D014945:Wound Healing
D001426:Bacterial Proteins; D003169:Complement Inactivator Proteins; D053878:Hemolytic Agents; C012749:anticomplement; D002336:Carnosine; D009113:Muramidase