Electroacupuncture treatment normalized sleep disturbance in morphine withdrawal rats.
Sleep disturbance is considered as an important symptom of acute and protracted opiate withdrawal. Current results suggest that sleep disturbance may be taken as a predictor of relapse. Appropriate sleep enhancement therapy will be in favor of the retention in treatment for opiate addicts. Our previous studies have shown that electroacupuncture (EA) is effective in suppressing morphine withdrawal syndrome. The aim of the present study is to investigate the effect of 2 and 100 Hz EA on the sleep disturbance during morphine withdrawal. Rats were made dependent on morphine by repeated morphine injections (escalating doses of 5-80 mg kg(-1), subcutaneously, twice a day) for 5 days. EA of 2 or 100 Hz was given twice a day for 3 days, starting at 48 h after the last morphine injection. Electroencephalogram and electromyogram were monitored at the end of the first and the last EA treatments, respectively. Results showed that non-rapid eye movement (NREM) sleep, REM sleep and total sleep time decreased dramatically, while the sleep latency prolonged significantly during acute morphine withdrawal. Both 2 and 100 Hz EA produced a significant increase in NREM sleep, REM sleep and total sleep time. It was suggested that EA could be a potential treatment for sleep disturbance during morphine withdrawal.
Li
Yi-Jing
YJ
Neuroscience Research Institute, Department of Neurobiology, School of Basic Medical Sciences, Peking University, Key Lab for Neuroscience, the Ministry of Education and Key Lab for Neuroscience, the Ministry of Public Health, Beijing 10019 1, China.
Zhong
Fei
F
Yu
Peng
P
Han
Ji-Sheng
JS
Cui
Cai-Lian
CL
Wu
Liu-Zhen
LZ