Biological significance of the maximum standardized uptake values on positron emission tomography in non-small cell lung cancer.
BACKGROUND
The 2-[18F]-fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) has recently become an important non-invasive tool for the diagnosis and staging in several cancers. The standardized uptake value (SUV) of primary tumor has been reported to relate to cancer progression and prognosis, however, biological mechanism is still unclear.


METHODS
Seventy-nine patients with non-small cell lung cancer (NSCLC) who had undergone preoperative FDG-PET and a surgical resection were enrolled in this study. NSCLC tissue samples prepared from the surgical specimens were subjected to an immunohistochemical analysis for the expression of Ki-67 and vascular endothelial growth factor (VEGF) proteins. The relationships between the expression status of these proteins and SUV(max) of primary tumors were evaluated.


RESULTS
Concerning the relationship with various clinicopathological findings, SUV(max) of primary tumors was associated with histology, tumor proliferation, pleural or vascular invasion, and pathological stage. A significant correlation was observed between the SUV(max) and either the Ki-67 or VEGF expression (P < 0.001, P = 0.006), respectively. Cases with both Ki-67-negative and VEGF-negative findings exhibited a significantly lower SUV(max) than those with single positive or double positive cases (P = 0.006, P < 0.001).


CONCLUSIONS
The SUV(max) was associated with the expression of Ki-67 and VEGF in NSCLC. These findings indicated that the SUV(max) of primary tumors might therefore reflect the biological malignant potential in NSCLC.
Takenaka
Tomoyoshi
T
Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. ttake@surg2.med.kyushu-u.ac.jp
Yano
Tokujiro
T
Ito
Kensaku
K
Morodomi
Yousuke
Y
Miura
Naoko
N
Kawano
Daigo
D
Shoji
Fumihiro
F
Abe
Koichiro
K
Honda
Hiroshi
H
Maehara
Yoshihiko
Y
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000737:chemistry / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000032:analysis; D008175:Lung Neoplasms / Q000737:chemistry / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D042461:Vascular Endothelial Growth Factor A / Q000032:analysis
D019394:Ki-67 Antigen; D019275:Radiopharmaceuticals; D042461:Vascular Endothelial Growth Factor A; D019788:Fluorodeoxyglucose F18