title: Animal models of spondyloarthritis.
abstract: Animal models are available for the study of several different aspects of spondyloarthritis. The models include naturally occurring spontaneous disorders in primates and rodents, spontaneous disorders in transgenic or gene-deleted rodents and induced disorders in rodents. Areas of investigation to which these models contribute include the role HLA-B27, processes of spinal and peripheral joint inflammation and calcification, immune responses to candidate antigens and the role of TNF.
authors.affiliation: Rheumatic Diseases Division, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-8884, USA. joel.taurog@utsouthwestern.edu
authors.forename: Joel D
authors.initials: JD
authors.lastname: Taurog
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D004195:Disease Models, Animal; D006801:Humans; D011509:Proteoglycans / Q000276:immunology; D025241:Spondylarthritis / Q000473:pathology / Q000503:physiopathology
chemical_list: D011509:Proteoglycans