[Variants of adiponectin gene as risk factors for the metabolic syndrome].
Adiponectin, a protein secreted by adipose tissue but present at low levels in obesity, is now widely recognized as a key determinant of insulin sensitivity and of protection against obesity-associated metabolic syndrome. The adiponectin gene is very polymorphic and several of its variants contribute to adiponectin level, function and are associated with metabolic syndrome phenotypes. The results differ ethnically. The association of identified variants with obesity and its consequences, type 2 diabetes and cardiovascular disease is reviewed. This data may enable patients at greater risk of the adverse effects of obesity to be identified and, as such, benefit from more targeted therapy and prevention.
Szopa
Magdalena
M
Zakład Biochemii Klinicznej, Collegium Medicum, Uniwersytet Jagielloński, Kraków.
Malczewska-Malec
Małgorzata
M
Wybrańska
Iwona
I
Kieć-Wilk
Beata
B
D052242:Adiponectin / Q000737:chemistry* / Q000235:genetics*; D014644:Genetic Variation; D006801:Humans; D007333:Insulin Resistance / Q000235:genetics; D024821:Metabolic Syndrome / Q000235:genetics*
D052242:Adiponectin