title: Parallel liquid-phase synthesis of 5-(1H-4-pyrazolyl)-[1,2,4]oxadiazole libraries.
abstract: Combinatorial libraries of substituted 3-(methylthio)-5-(amino)-4-([1,2,4]oxadiazol-5-yl)-1H-pyrazoles 6, 10, 13, 15 (395 members, yields 32-87%), 4-([1,2,4]oxadiazol-5-yl)-1H-3,5-pyrazolediamines 8, 11 (571 members, yields 25-83%), 2-(methylthio)-3-([1,2,4]oxadiazol-5-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-ones 17 (85 members, yields 56-95%), and 2-(amino)-3-([1,2,4]oxadiazol-5-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-ones 18 (110 members, yields 56-95%) were synthesized by the parallel liquid-phase synthesis method.
authors.affiliation: National University of Pharmacy, Pushkinska str.53, 61002 Kharkiv, Ukraine. borisov@onet.com.ua
authors.forename: Alexander V
authors.initials: AV
authors.lastname: Borisov
authors.forename: Oleksandr S
authors.initials: OS
authors.lastname: Detistov
authors.forename: Viktoria I
authors.initials: VI
authors.lastname: Pukhovaya
authors.forename: Irina O
authors.initials: IO
authors.lastname: Zhuravel'
authors.forename: Sergiy M
authors.initials: SM
authors.lastname: Kovalenko
mesh_terms: D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D015394:Molecular Structure; D010069:Oxadiazoles / Q000138:chemical synthesis* / Q000737:chemistry; D011720:Pyrazoles / Q000737:chemistry; D054852:Small Molecule Libraries; D013237:Stereoisomerism
chemical_list: D010069:Oxadiazoles; D011720:Pyrazoles; D054852:Small Molecule Libraries