title: Prognostic factors and clinicopathological characteristics of carcinoma of ampulla Vateri.
abstract: The aim of this study was to describe the clinicopathological characteristics and prognostic factors of carcinoma of ampulla Vateri. The medical records of 32 patients (24 men, 8 women) were evaluated. Median age was 59 years (range, 36-80 years). The performance status at the time of admission of (European Cooperative Oncology Group) 18 patients (56.3%) were ECOG-1; 8 patients (25.0%) were ECOG-2. Fifteen patients had early stage, 15 patients had locally advanced stage. Twenty-eight of 32 patients underwent curative surgery. Eleven, nine, and four patients had high-, moderate-, and low-grade histology, respectively. Fourteen patients received adjuvant treatment. Ten out of 14 patients were treated with chemotherapy. ECOG performance status (P = 0.06), stage (P = 0.05), perineural invasion (P = 0.01), tumor grade (P = 0.01), and treatment with chemotherapy, chemoradiotherapy, or only radiotherapy (P = 0.001) had a statistically significant impact on overall survival, whereas only tumor histopathology (P < 0.001) was shown to have a statistically significant effect on disease-free survival. Carcinoma of ampulla Vateri is a rare gastrointestinal tumor. Prospective trials with larger number of patients are needed to determine the prognostic factors to help select patients for adjuvant treatment.
authors.affiliation: Department of Internal Medicine, Ankara Numune Education and Research Hospital, Ankara, Turkey. drmpamuk@yahoo.com
authors.forename: Merve
authors.initials: M
authors.lastname: Pamukcuoglu
authors.forename: Berna
authors.initials: B
authors.lastname: Oksuzoglu
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Abali
authors.forename: Musa
authors.initials: M
authors.lastname: Akoglu
authors.forename: Fuat
authors.initials: F
authors.lastname: Atalay
authors.forename: Burcin
authors.initials: B
authors.lastname: Budakoglu
authors.forename: Dogan
authors.initials: D
authors.lastname: Uncu
authors.forename: Nuriye Yildirim
authors.initials: NY
authors.lastname: Ozdemir
authors.forename: Tunc
authors.initials: T
authors.lastname: Guler
authors.forename: Nurullah
authors.initials: N
authors.lastname: Zengin
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014670:Ampulla of Vater; D003138:Common Bile Duct Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011379:Prognosis; D012189:Retrospective Studies