[Chronic mild inflammation links obesity, metabolic syndrome, atherosclerosis and diabetes].
Chronic low grade inflammation is relatively new concept in metabolic medicine. This concept describes the relations between the inflammation and adipose tissue, insulin resistence, atherosclerosis and type 2 diabetes mellitus. Macrophages and lymphocytes deposed in adipose tissue produce proinflammatory cytokines which directly or through the CRP liver secretion are targeting endothelial cells, hepatocytes and beta cells of Langerhans islets of pancreas. The dysfunction of these cells follows often further disturbances and in case of beta cells - the cell death. The connection between the adipose tissue insulin resistence, atherosclerosis and type 2 diabetes was earlier described with endocrine and metabolic descriptors. The concept of chronic low grade inflammation creates also another description of multilateral connections in metabolic syndome. The salicylates and the drugs related to them seem to have some glucose lowering properties. The recent development in the field ofchronic low grade inflammation represents also certain therapeutic hope for antiinflammatory intervention in type 2 diabetes.
Andel
M
M
Centrum pro výzkum diabetu, metabolismu a výzivy 3. lékarské fakulty UK a FN Královské Vinohrady Praha. michal.andel@lf3.cuni.cz
Polák
J
J
Kraml
P
P
Dlouhý
P
P
Stich
V
V
D050197:Atherosclerosis / Q000150:complications* / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000503:physiopathology; D006801:Humans; D007249:Inflammation / Q000150:complications*; D024821:Metabolic Syndrome / Q000150:complications* / Q000503:physiopathology; D009765:Obesity / Q000150:complications* / Q000503:physiopathology