Transcriptional regulation by TAL1: a link between epigenetic modifications and erythropoiesis.
TAL1/SCL (hereafter referred to as TAL1) is a critical transcription factor required for hematopoiesis in which hematopoietic stem cells commit and differentiate to different lineages. During this process, transcription of many genes is turned on and off in part by epigenetic mechanisms. TAL1 has recently been shown to differentially recruit LSD1 and other histone modifying complexes to regulate its target genes. Here, we focus primarily on epigenetic mechanisms that are regulated by TAL1 during normal and malignant hematopoiesis. We discuss how different histone modifying enzymes are recruited by TAL1 and how these enzymatic activities mediate the activating or repressive function of TAL1. Finally, we further explore the possible mechanisms by which dysregulation of the recruitment and activity of histone modifying enzymes contribute to leukemogenesis.
Hu
Xin
X
Edmond H. Fischer Signal Transduction Laboratory, College of Life Science, Jilin University, Changchun, China.
Ybarra
River
R
Qiu
Yi
Y
Bungert
Jörg
J
Huang
Suming
S
D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D044127:Epigenesis, Genetic; D004920:Erythropoiesis / Q000235:genetics*; D005786:Gene Expression Regulation; D051548:Histone Acetyltransferases / Q000378:metabolism / Q000502:physiology; D006655:Histone Deacetylases / Q000378:metabolism / Q000502:physiology; D006657:Histones / Q000378:metabolism; D008745:Methylation; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*
D051792:Basic Helix-Loop-Helix Proteins; D051548:Histone Acetyltransferases; D006655:Histone Deacetylases; D006657:Histones; D011518:Proto-Oncogene Proteins