Recent progress on STIM1 domains controlling Orai activation.
Ca(2+) entry in non-excitable cells is mainly carried by store-operated channels among which the CRAC channel is best characterized. Its two limiting molecular components are represented by the Ca(2+) sensor protein STIM1 located in the endoplasmic reticulum and Orai1 in the plasma membrane. STIM1 senses a decrease of the Ca(2+) content in internal stores and triggers its accumulation into puncta like structures resulting in coupling to as well as activation of Orai1 channels. The STIM1-Orai coupling process is determined by an interaction via their C-termini. This review highlights recent developments on domains particularly within the cytosolic part of STIM1 that govern this interaction.
Schindl
R
R
Institute of Biophysics, University of Linz, A-4040 Linz, Austria. rainer.schindl@jku.at
Muik
M
M
Fahrner
M
M
Derler
I
I
Fritsch
R
R
Bergsmann
J
J
Romanin
C
C
D000818:Animals; D002118:Calcium / Q000737:chemistry* / Q000378:metabolism*; D015220:Calcium Channels / Q000737:chemistry* / Q000378:metabolism* / Q000648:ultrastructure*; D002462:Cell Membrane / Q000378:metabolism / Q000648:ultrastructure; D004721:Endoplasmic Reticulum / Q000378:metabolism / Q000648:ultrastructure; D006801:Humans; D015640:Ion Channel Gating; D008565:Membrane Proteins / Q000737:chemistry* / Q000378:metabolism* / Q000648:ultrastructure*; D009363:Neoplasm Proteins / Q000737:chemistry* / Q000378:metabolism* / Q000648:ultrastructure*; D000071740:ORAI1 Protein; D011485:Protein Binding; D054730:Protein Interaction Domains and Motifs; D000071737:Stromal Interaction Molecule 1
D015220:Calcium Channels; D008565:Membrane Proteins; D009363:Neoplasm Proteins; D000071740:ORAI1 Protein; C510746:ORAI1 protein, human; C103530:STIM1 protein, human; D000071737:Stromal Interaction Molecule 1; D002118:Calcium