title: Recurrence of hepatitis C virus (genotype 4) infection after living-donor liver transplant in Egyptian patients.
abstract: OBJECTIVE
  The recurrence of hepatitis C virus infection after liver transplant is common and may endanger both graft and patient survival. We investigated the frequency and outcome of and risk factors for the recurrence of that virus after living-donor liver transplant in hepatitis C virus positive recipients.
  
  
  METHODS
  Seventy-four adult hepatitis C virus positive subjects were monitored for 36 months after living-donor liver transplant and demographic and laboratory data for the recipients and donors were evaluated. Recurrent hepatitis C virus infection was diagnosed on the basis of viral replication revealed by polymerase chain reaction after transplant, elevated levels of transaminases, and the results of liver biopsy.
  
  
  RESULTS
  Hepatitis C virus recurrence was identified in 31.1% of the patients studied. Histopathologic recurrence was mild, and 91% of the subjects had a fibrosis score of < or = F2. No recipient exhibited cirrhosis or clinical decompensation during followup. Recurrent hepatitis C virus infection was associated with pretransplant and posttransplant viral load and antibody positive to hepatitis B core antigen. No other risk factors (sex, donor or recipient age, pretransplant Child-Pugh or Model for End-Stage Liver Disease scores, immunosuppressive drug therapy, and treatment with pulse steroids) were significantly correlated with the frequency of hepatitis C virus recurrence, the grade of the histologic activity index, or the stage of fibrosis.
  
  
  CONCLUSIONS
  In living-donor liver transplant recipients, patient and graft survival rates associated with hepatitis C virus (genotype 4) related cirrhosis were comparable to those in deceased-donor liver transplant recipients reported in the literature. Recurrent infection with hepatitic C virus after living-donor liver transplant was mild. After transplant, a higher viral load and the presence of antibody to hepatitis B core antigen could be risk factors for hepatitis C virus recurrence. Long-term follow-up in a large number of patients is required.
authors.affiliation: Liver Transplantation Center, Dar Al-Fouad Hospital, Giza, Egypt. ayosry@tedata.net.eg
authors.forename: Ayman
authors.initials: A
authors.lastname: Yosry
authors.forename: Mahasen
authors.initials: M
authors.lastname: Abdel-Rahman
authors.forename: Gamal
authors.initials: G
authors.lastname: Esmat
authors.forename: Magdy
authors.initials: M
authors.lastname: El-Serafy
authors.forename: Ashraf
authors.initials: A
authors.lastname: Omar
authors.forename: Waheed
authors.initials: W
authors.lastname: Doss
authors.forename: Nagla
authors.initials: N
authors.lastname: Zayed
authors.forename: Mohamed
authors.initials: M
authors.lastname: Said
authors.forename: Tamer
authors.initials: T
authors.lastname: Ismail
authors.forename: Adel
authors.initials: A
authors.lastname: Hosny
authors.forename: Ebrahem
authors.initials: E
authors.lastname: Marawan
authors.forename: Osama
authors.initials: O
authors.lastname: El-Malt
authors.forename: Refaat Refaat
authors.initials: RR
authors.lastname: Kamel
authors.forename: Yaser
authors.initials: Y
authors.lastname: Hatata
authors.forename: Ahmad
authors.initials: A
authors.lastname: El-Taweel
authors.forename: Ahmad
authors.initials: A
authors.lastname: Ghali
authors.forename: Hussein
authors.initials: H
authors.lastname: Sabri
authors.forename: Sanaa
authors.initials: S
authors.lastname: Kamel
authors.forename: Hatem
authors.initials: H
authors.lastname: El-Gabaly
mesh_terms: D000328:Adult; D001706:Biopsy; D044383:Black People / Q000706:statistics & numerical data*; D006528:Carcinoma, Hepatocellular / Q000208:ethnology / Q000473:pathology / Q000601:surgery* / Q000821:virology; D004534:Egypt / Q000453:epidemiology; D005260:Female; D005838:Genotype; D016174:Hepacivirus / Q000235:genetics* / Q000276:immunology; D006510:Hepatitis B Antibodies / Q000097:blood; D006512:Hepatitis B Core Antigens / Q000276:immunology; D006526:Hepatitis C / Q000150:complications* / Q000175:diagnosis / Q000208:ethnology; D006801:Humans; D008103:Liver Cirrhosis / Q000208:ethnology / Q000473:pathology / Q000601:surgery* / Q000821:virology; D008113:Liver Neoplasms / Q000208:ethnology / Q000473:pathology / Q000601:surgery* / Q000821:virology; D016031:Liver Transplantation / Q000208:ethnology*; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012367:RNA, Viral / Q000097:blood; D012008:Recurrence; D012307:Risk Factors; D012720:Severity of Illness Index; D013997:Time Factors; D016896:Treatment Outcome; D019562:Viral Load; D014779:Virus Replication
chemical_list: D006510:Hepatitis B Antibodies; D006512:Hepatitis B Core Antigens; D012367:RNA, Viral