title: Prolonged hypothermia as a bridge to recovery for cerebral edema and intracranial hypertension associated with fulminant hepatic failure.
abstract: BACKGROUND
  To review evidence-based treatment options in patients with cerebral edema complicating fulminant hepatic failure (FHF) and discuss the potential applications of hypothermia.
  
  
  METHODS
  Case-based observations from a medical intensive care unit (MICU) in a tertiary care facility in a 27-year-old female with FHF from acetaminophen and resultant cerebral edema.
  
  
  RESULTS
  Our patient was admitted to the MICU after being found unresponsive with presumed toxicity from acetaminophen which was ingested over a 2-day period. The patient had depressed of mental status lasting at least 24 h prior to admission. Initial evaluation confirmed FHF from acetaminophen and cerebral edema. The patient was treated with hyperosmolar therapy, hyperventilation, sedation, and chemical paralysis. Her intracranial pressure remained elevated despite maximal medical therapy. We then initiated therapeutic hypothermia which was continued for 5 days. At re-warming, patient had resolution of her cerebral edema and intracranial hypertension. At discharge, she had complete recovery of neurological and hepatic functions.
  
  
  CONCLUSIONS
  In patients with FHF and cerebral edema from acetaminophen overdose, prolonged therapeutic hypothermia could potentially be used as a life saving therapy and a bridge to hepatic and neurological recovery. A clinical trial of hypothermia in patients with this condition is warranted.
authors.affiliation: Division of Pulmonary and Critical Care Medicine, The Medical College of Wisconsin, 9200 West Wisconsin Ave., Milwaukee, WI 53226, USA.
authors.forename: Shibin
authors.initials: S
authors.lastname: Jacob
authors.forename: Ahmed
authors.initials: A
authors.lastname: Khan
authors.forename: Elizabeth R
authors.initials: ER
authors.lastname: Jacobs
authors.forename: Prem
authors.initials: P
authors.lastname: Kandiah
authors.forename: Rahul
authors.initials: R
authors.lastname: Nanchal
mesh_terms: D000082:Acetaminophen / Q000633:toxicity*; D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging; D001929:Brain Edema / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000628:therapy; D005260:Female; D006801:Humans; D007035:Hypothermia / Q000209:etiology* / Q000628:therapy; D007036:Hypothermia, Induced / Q000379:methods*; D019586:Intracranial Hypertension / Q000209:etiology / Q000503:physiopathology* / Q000628:therapy; D017114:Liver Failure, Acute / Q000139:chemically induced / Q000150:complications* / Q000601:surgery; D016031:Liver Transplantation; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000082:Acetaminophen