title: Enantioselective conjugate addition employing 2-heteroaryl titanates and zinc reagents.
abstract: A general strategy for the conjugate addition of 2-heteroaryl nucleophiles to cyclic enones, unsaturated lactones, and unsaturated lactams in high enantioselectivities and yields is reported. The use of 2-heteroaryl titanates and zinc reagents offers a practical alternative to 2-heteroarylboronic acids, which are prone to undergo protodeboronation.
authors.affiliation: Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, Texas 78712, USA.
authors.forename: Anna J
authors.initials: AJ
authors.lastname: Smith
authors.forename: Lily K
authors.initials: LK
authors.lastname: Abbott
authors.forename: Stephen F
authors.initials: SF
authors.lastname: Martin
mesh_terms: D002384:Catalysis; D003500:Cyclization; D007202:Indicators and Reagents / Q000737:chemistry; D013237:Stereoisomerism; D014025:Titanium / Q000737:chemistry*; D015032:Zinc / Q000737:chemistry*
chemical_list: D007202:Indicators and Reagents; D014025:Titanium; D015032:Zinc