title: Biscarpamontamines A and B, an aspidosperma-iboga bisindole alkaloid and an aspidosperma-aspidosperma bisindole alkaloid, from Tabernaemontana sphaerocarpa.
abstract: Two new bisindole alkaloids, biscarpamontamine A (1), possessing an aspidosperma-iboga-type skeleton, and biscarpamontamine B (2), having an aspidosperma-aspidosperma-type skeleton, were isolated from stems of Tabernaemontana sphaerocarpa, and their structures were elucidated on the basis of spectroscopic data analysis. The absolute configuration of biscarpamontamine B (2) was established by comparison of its CD spectrum and with that of vobtusine (3). Biscarpamontamine B (2) showed potent cytotoxicity against various human cancer cell lines.
authors.affiliation: Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa, Tokyo, Japan.
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Zaima
authors.forename: Tomoko
authors.initials: T
authors.lastname: Hirata
authors.forename: Takahiro
authors.initials: T
authors.lastname: Hosoya
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Hirasawa
authors.forename: Koichiro
authors.initials: K
authors.lastname: Koyama
authors.forename: Abdul
authors.initials: A
authors.lastname: Rahman
authors.forename: Idha
authors.initials: I
authors.lastname: Kusumawati
authors.forename: Noor Cholies
authors.initials: NC
authors.lastname: Zaini
authors.forename: Motoo
authors.initials: M
authors.lastname: Shiro
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Morita
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D030009:Aspidosperma / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D045325:HCT116 Cells; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007214:Indonesia; D015394:Molecular Structure; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D030014:Tabernaemontana / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D026121:Indole Alkaloids; C544369:biscarpamontamine A; C544370:biscarpamontamine B