title: Administration of anti-glucagon-like peptide-2 serum suppresses epithelial cell proliferation of the distal small intestine in weanling rats.
abstract: We investigated the effects of endogenous glucagon-like peptide-2 (GLP-2) on the development of intestinal mucosa in weanling rats. Three-week-old male weanling Sprague-Dawley rats were administered either anti-GLP-2 or normal rabbit serum every other day for 2 weeks. We then measured length, weight, and bromodeoxyuridine incorporation in the intestine on day 13 following the first injection. Administration of anti-GLP-2 serum significantly inhibited both epithelial proliferation in the distal ileum and elongation of the small intestine. These results suggest that intrinsic GLP-2 contributes to the growth of the small intestine during the weanling period.
authors.affiliation: Hokkaido University, Sapporo, Japan. zuka@chem.agr.hokudai.ac.jp
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ishizuka
authors.forename: Ayako
authors.initials: A
authors.lastname: Inafune
authors.forename: Tohru
authors.initials: T
authors.lastname: Hira
authors.forename: Hirohisa
authors.initials: H
authors.lastname: Izumi
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Ozawa
authors.forename: Mitsunori
authors.initials: M
authors.lastname: Takase
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hara
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D053767:Glucagon-Like Peptide 2 / Q000037:antagonists & inhibitors / Q000276:immunology / Q000378:metabolism*; D007082:Ileum / Q000166:cytology / Q000254:growth & development* / Q000276:immunology / Q000378:metabolism; D007106:Immune Sera / Q000276:immunology / Q000494:pharmacology*; D007413:Intestinal Mucosa / Q000166:cytology / Q000254:growth & development* / Q000276:immunology / Q000378:metabolism; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D014886:Weaning
chemical_list: D053767:Glucagon-Like Peptide 2; D007106:Immune Sera