title: Enlarged analogues of uniconazole, new azole containing inhibitors of ABA 8'-hydroxylase CYP707A.
abstract: We enlarged the uniconazole (UNI) molecule to find a specific inhibitor of abscisic acid (ABA) 8'-hydroxylase, and synthesized various UNI derivatives that were substituted with hydrophilic and hydrophobic groups at the 4-chlorine of the phenyl group of UNI using click chemistry. Considering its potency in ABA 8'-hydroxylase inhibition, its small effect on seedling growth, and its ease of application, UT4, the UNI derivative containing the C4 alkyltriazole, was the best candidate for a highly selective inhibitor of ABA 8'-hydroxylase.
authors.affiliation: Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, Shizuoka 422-8529, Japan. aytodor@agr.shizuoka.ac.jp
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Todoroki
authors.forename: Hikaru
authors.initials: H
authors.lastname: Aoyama
authors.forename: Saori
authors.initials: S
authors.lastname: Hiramatsu
authors.forename: Minaho
authors.initials: M
authors.lastname: Shirakura
authors.forename: Hataitip
authors.initials: H
authors.lastname: Nimitkeatkai
authors.forename: Satoru
authors.initials: S
authors.lastname: Kondo
authors.forename: Kotomi
authors.initials: K
authors.lastname: Ueno
authors.forename: Masaharu
authors.initials: M
authors.lastname: Mizutani
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Hirai
mesh_terms: D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D027845:Malus / Q000254:growth & development; D012275:Oryza / Q000254:growth & development; D010940:Plant Proteins; D011994:Recombinant Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism; D036226:Seedlings / Q000187:drug effects / Q000254:growth & development; D014230:Triazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D065607:Cytochrome P-450 Enzyme Inhibitors; D004791:Enzyme Inhibitors; D010940:Plant Proteins; D011994:Recombinant Proteins; D014230:Triazoles; D003577:Cytochrome P-450 Enzyme System; C107203:abscisic acid 8'-hydroxylase; C092705:uniconazole