title: [Sense of smell, physiological ageing and neurodegenerative diseases: I. Anatomy and clinical examination].
abstract: BACKGROUND
  Different studies on normal and pathological ageing have shown structural and functional impairment by means of psychophysical measures, electrophysiological studies and brain imaging studies. Lower sensory perception from peripheral olfactory structures, together with alterations in the medulla oblongata and cortex, are the most frequent causes of olfactory impairment in ageing.
  
  
  OBJECTIVE
  To outline the most important tests that can be applied in clinical evaluation.
  
  
  METHODS
  The article begins by reviewing concepts involved in olfactory anatomy and physiology and then goes on to describe the different methods of examination and their applicability to medical diagnosis.
  
  
  CONCLUSIONS
  Incorporating olfactory tests into clinical practice makes it possible to study the presence of sensory and cognitive impairment in greater depth, especially in ageing and in neurodegenerative diseases; this will allow a possible diagnosis to be expanded and completed.
authors.affiliation: Facultad de Psicología, Universidad Nacional de Educacion a Distancia, Facultad de Psicologia, Madrid, Espana. ninafusari@googlemail.com
authors.forename: A
authors.initials: A
authors.lastname: Fusari
authors.forename: J A
authors.initials: JA
authors.lastname: Molina
mesh_terms: D000375:Aging / Q000502:physiology*; D006801:Humans; D008568:Memory; D019636:Neurodegenerative Diseases / Q000503:physiopathology*; D009831:Olfactory Mucosa / Q000033:anatomy & histology / Q000502:physiology; D009833:Olfactory Pathways / Q000033:anatomy & histology / Q000502:physiology; D012903:Smell / Q000502:physiology*