Solvent free synthesis of 1,5-disubstituted tetrazoles derived from Baylis Hillman acetates as potential TNF-alpha inhibitors.
Solvent free multicomponent reaction of Baylis Hillman acetate, TMS azide and arylnitrile to produce 1,5-disubstituted tetrazole is described. Some of these tetrazoles are found to be potential TNF-alpha inhibitors.
Srihari
P
P
Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad 500 607, India. srihari@iict.res.in
Dutta
Palash
P
Rao
R Srinivasa
RS
Yadav
J S
JS
Chandrasekhar
S
S
Thombare
P
P
Mohapatra
J
J
Chatterjee
A
A
Jain
Mukul R
MR
D000085:Acetates / Q000737:chemistry*; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D012997:Solvents / Q000737:chemistry; D013777:Tetrazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors* / Q000378:metabolism
D000085:Acetates; D000893:Anti-Inflammatory Agents; D012997:Solvents; D013777:Tetrazoles; D014409:Tumor Necrosis Factor-alpha