Effect of minimally invasive surgery for cerebral hematoma evacuation in different stages on motor evoked potential and thrombin in dog model of intracranial hemorrhage.
OBJECTIVE
To observe the effect of minimally invasive surgery for cerebral hematoma evacuation in different stages on motor evoked potential (MEP) and thrombin in dog model of intracranial hemorrhage.


METHODS
Twenty dogs were selected to prepare the intracranial hemorrhage model, which were randomly divided into 6, 12, 18 and 24 hour groups, respectively. The animals in each group underwent a minimally invasive surgery to evacuate the cerebral hematoma after the models were prepared. Before and after procedures, Purdy score, MEP and thrombin in hematoma region were determined and compared.


RESULTS
Significant decreases in Purdy score, latency of MEP and thrombin expression were observed in 6 and 12 hour groups as compared with the 18 and 24 hour groups (p<0.01).


CONCLUSIONS
In the present experiment, we established a dog model of intracranial hemorrhage, which was minimally invasive, easy to operate, highly repeated, simulating the pathological and physiological changes of clinical hypertensive intracranial hemorrhage. Both the latency of MEP and the expression of thrombin decreased after evacuation of intracranial hematoma in early stages by minimally invasive procedures, indicating that minimally invasive procedures for cerebral hematoma in ultra-early and early stages might be more effective to limit brain injury and decrease the latency of MEP and thrombin expression.
Wu
Guofeng
G
Department of Emergency, Guiyang Medical College, No. 28 Guiyi Street, Liuguangmen, Guiyang 550004, China. wuguofeng3013@sina.com
Zhong
Weibin
W
D000818:Animals; D004195:Disease Models, Animal; D004285:Dogs; D019054:Evoked Potentials, Motor / Q000502:physiology*; D005260:Female; D046648:Hematoma, Subdural, Intracranial / Q000378:metabolism / Q000503:physiopathology / Q000601:surgery*; D020300:Intracranial Hemorrhages / Q000378:metabolism / Q000503:physiopathology / Q000601:surgery*; D008297:Male; D019060:Minimally Invasive Surgical Procedures / Q000379:methods*; D013917:Thrombin / Q000096:biosynthesis*
D013917:Thrombin