HLA B27 as predisposition factor to suffer age related macular degeneration.
To research whether specific alleles HLA class I (HLA-A and HLA-B) and class II (HLA-DR) are risk factors for the development of exudative type of Age Related Macular Degeneration (ARMD), HLA antigens are expressed both in normal and affected eyes with ARMD. We designed a prospective case-controlled study. We recruited 75 patients with choroidal neovascularization predominantly classic or occult, secondary to ARMD, and treated with photodynamic therapy. Two hundred and fifty patients over 55 years old, without ophthalmologic pathology who went to hospital for an analytical routine check were used as control. The analysis of the data shows a significant difference between two groups. Allele HLA-B27 correlated positively with ARMD (p < 0.0113). However, we didn't find alleles negatively associated. Thus HLA-B27 is an allele predisposed to suffer ARMD.
Villegas Becerril
Enrique
E
Hospital Universitario Reina Sofia, CP 14011, Córdoba, Spain. drvill@terra.es
González Fernández
Rafael
R
Pérula Torres
Luis
L
Lacomba
Manuel Santos
MS
Gallardo Galera
José María
JM
D000368:Aged; D000369:Aged, 80 and over; D020256:Choroidal Neovascularization / Q000209:etiology / Q000235:genetics* / Q000503:physiopathology / Q000628:therapy; D005122:Exudates and Transudates / Q000378:metabolism*; D005260:Female; D020022:Genetic Predisposition to Disease; D015234:HLA-A Antigens / Q000235:genetics; D015796:HLA-B27 Antigen / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics; D006650:Histocompatibility Testing; D006801:Humans; D008268:Macular Degeneration / Q000150:complications / Q000235:genetics* / Q000503:physiopathology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010778:Photochemotherapy; D011110:Polymorphism, Genetic; D011446:Prospective Studies; D012307:Risk Factors
D015234:HLA-A Antigens; D015796:HLA-B27 Antigen; D006684:HLA-DR Antigens