title: A novel one-pot three-(in situ five-)component condensation reaction: an unexpected approach for the synthesis of tetrahydro-2,4-dioxo-1H-benzo[b][1,5]diazepine-3-yl-2-methylpropanamide derivatives.
abstract: A novel and efficient method has been developed for the synthesis of tetrahydro-2,4-dioxo-1H-benzo[b][1,5]diazepine-3-yl-2-methylpropanamide derivatives using an aromatic diamine, Meldrum's acid, and an isocyanide in CH(2)Cl(2) at ambient temperature in high yields without using any catalyst or activation. The procedure provides an alternative method for the synthesis of benzo[b][1,5]diazepine derivatives. These compounds have closely related ring systems such as triflubazam, clobazam, and 1,5-benzodiazepines, which have a broad spectrum of biological activities.
authors.affiliation: Department of Chemistry, Shahid Beheshti University, P.O. Box 19396-4716, Tehran, Iran. a-shaabani@cc.sbu.ac.ir
authors.forename: Ahmad
authors.initials: A
authors.lastname: Shaabani
authors.forename: Ali Hossein
authors.initials: AH
authors.lastname: Rezayan
authors.forename: Sajjad
authors.initials: S
authors.lastname: Keshipour
authors.forename: Afshin
authors.initials: A
authors.lastname: Sarvary
authors.forename: Seik Weng
authors.initials: SW
authors.lastname: Ng
mesh_terms: D000627:Aminophenols / Q000737:chemistry; D001569:Benzodiazepines / Q000138:chemical synthesis* / Q000737:chemistry; D003486:Cyanides / Q000737:chemistry*; D003959:Diamines / Q000737:chemistry*; D004146:Dioxanes / Q000737:chemistry*
chemical_list: D000627:Aminophenols; D003486:Cyanides; D003959:Diamines; D004146:Dioxanes; D001569:Benzodiazepines; C027667:2-aminophenol; C076489:Meldrum's acid