Facile formation of dehydroalanine from S-nitrosocysteines.
A reductive elimination of S-nitrosocysteines using phosphine substrates has been developed. This reaction converts unstable S-nitrosocysteines to dehydroalanine derivatives under very mild conditions. It can potentially be applied for the detection of protein S-nitrosation.
Wang
Hua
H
Department of Chemistry, Washington State University, Pullman, Washington 99164, USA.
Zhang
Jiming
J
Xian
Ming
M
D000409:Alanine / Q000031:analogs & derivatives* / Q000737:chemistry; D002384:Catalysis; D003545:Cysteine / Q000031:analogs & derivatives* / Q000737:chemistry; D010720:Phosphines / Q000737:chemistry; D026403:S-Nitrosothiols / Q000737:chemistry*
D010720:Phosphines; D026403:S-Nitrosothiols; C021315:S-nitrosocysteine; C015102:dehydroalanine; C044646:phosphine; D003545:Cysteine; D000409:Alanine