title: A direct synthesis of 5,6-dihydroindolo[2,1-a]isoquinolines that exhibit immunosuppressive activity.
abstract: Dihydroindolo[2,1-a]isoquinolines were synthesized from tetrahydroisoquinolines and alpha-fluoroaldehydes by a novel two-step procedure. These compounds exhibited significant immunosuppressive activity against IL-2, IL-10 and IFN-gamma.
authors.affiliation: Department of Chemistry, Iowa State University, Ames, IA 50011, USA. gakraus@iastate.edu
authors.forename: George A
authors.initials: GA
authors.lastname: Kraus
authors.forename: Vinayak
authors.initials: V
authors.lastname: Gupta
authors.forename: Marian
authors.initials: M
authors.lastname: Kohut
authors.forename: Navrozedeep
authors.initials: N
authors.lastname: Singh
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000818:Animals; D007166:Immunosuppressive Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D007371:Interferon-gamma / Q000378:metabolism; D016753:Interleukin-10 / Q000378:metabolism; D007376:Interleukin-2 / Q000378:metabolism; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism; D044005:Tetrahydroisoquinolines / Q000737:chemistry
chemical_list: D000447:Aldehydes; D007166:Immunosuppressive Agents; D007376:Interleukin-2; D007546:Isoquinolines; D044005:Tetrahydroisoquinolines; D016753:Interleukin-10; D007371:Interferon-gamma