Getting to the root of BRCA1-deficient breast cancer.
Loss of BRCA1 has been shown to expand breast stem cells. In Nature Medicine, Lim et al. (2009) demonstrate that breast tissue from BRCA1 mutation carriers contains expanded luminal progenitor cells, suggesting a broader role for BRCA1 in mammary development.
Ginestier
Christophe
C
Centre de Recherche en Cancérologie de Marseille, Laboratoire d'Oncologie Moléculaire, UMR891 Inserm/Institut Paoli-Calmettes, Marseille, France.
Liu
Suling
S
Wicha
Max S
MS
D000818:Animals; D019313:BRCA1 Protein / Q000172:deficiency*; D001943:Breast Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D002454:Cell Differentiation; D004195:Disease Models, Animal; D005260:Female; D018628:Gene Dosage; D006801:Humans; D042361:Mammary Glands, Human / Q000166:cytology; D051379:Mice; D013234:Stem Cells / Q000166:cytology
D019313:BRCA1 Protein