title: A cell culture (Vero)-derived H5N1 whole-virus vaccine induces cross-reactive memory responses.
abstract: Novel strategies are required to provide rapid vaccine coverage in the event of an influenza pandemic. A phase I/II dose finding/formulation study was performed with a whole-virus H5N1 clade 1 A/Vietnam vaccine (2-dose priming regimen) to evaluate safety and immunogenicity. Seventy-seven of 141 subjects in this study received a booster (12-17 months after priming) with a 7.5-microg dose of a clade 2.1 A/Indonesia vaccine. The prime-boost regimen resulted in antibody responses against clade 1, 2.1, 2.2, and 2.3 viruses that were significantly higher than those after the priming regimen. These findings demonstrate that a prime-boost regimen may alleviate vaccine supply constraints in a pandemic.
authors.affiliation: Global R&D, Baxter BioScience, Vienna, Austria.
authors.forename: Hartmut J
authors.initials: HJ
authors.lastname: Ehrlich
authors.forename: Markus
authors.initials: M
authors.lastname: Müller
authors.forename: Sandor
authors.initials: S
authors.lastname: Fritsch
authors.forename: Markus
authors.initials: M
authors.lastname: Zeitlinger
authors.forename: Greg
authors.initials: G
authors.lastname: Berezuk
authors.forename: Alexandra
authors.initials: A
authors.lastname: Löw-Baselli
authors.forename: Maikel V W
authors.initials: MV
authors.lastname: van der Velden
authors.forename: Eva Maria
authors.initials: EM
authors.lastname: Pöllabauer
authors.forename: Friedrich
authors.initials: F
authors.lastname: Maritsch
authors.forename: Borislava G
authors.initials: BG
authors.lastname: Pavlova
authors.forename: Paul A
authors.initials: PA
authors.lastname: Tambyah
authors.forename: Helen M L
authors.initials: HM
authors.lastname: Oh
authors.forename: Emanuele
authors.initials: E
authors.lastname: Montomoli
authors.forename: Otfried
authors.initials: O
authors.lastname: Kistner
authors.forename: P
authors.initials: P
authors.lastname: Noel Barrett
mesh_terms: D000818:Animals; D000914:Antibodies, Viral; D002522:Chlorocebus aethiops; D004306:Dose-Response Relationship, Immunologic; D006801:Humans; D007117:Immunization, Secondary; D007156:Immunologic Memory; D053124:Influenza A Virus, H5N1 Subtype / Q000276:immunology*; D007252:Influenza Vaccines / Q000008:administration & dosage / Q000276:immunology*; D007251:Influenza, Human / Q000517:prevention & control; D014709:Vero Cells
chemical_list: D000914:Antibodies, Viral; D007252:Influenza Vaccines