title: Chromosome 8 pentasomy with partial tandem duplication of 11q23 in a case of de novo acute myeloid leukemia.
abstract: Polysomy 8 is a rare abnormality, one that has been reported as associated with secondary evolution, monocytic differentiation, or poor prognosis in myeloid neoplasm. In contrast to tetrasomy 8, which is most commonly observed, pentasomy 8 is a minority component of polysomy 8. To date, only three cases of pentasomy 8 accompanied with 11q23 rearrangement have been reported. Reported here is a novel case of pentasomy 8 with partial tandem duplication of 11q23 in de novo acute myeloid leukemia. The findings contribute to understanding of the relation between the two abnormalities, which have their own individual leukemogenic potencies.
authors.affiliation: Department of Laboratory Medicine, Chungnam National University Hospital, 640 Daesadong, Jung-Gu, Daejeon, South Korea.
authors.forename: So Youn
authors.initials: SY
authors.lastname: Shin
authors.forename: Sun Hoe
authors.initials: SH
authors.lastname: Koo
authors.forename: Kye Chul
authors.initials: KC
authors.lastname: Kwon
authors.forename: Jong Woo
authors.initials: JW
authors.lastname: Park
authors.forename: Jeong Hoon
authors.initials: JH
authors.lastname: Song
authors.forename: Young Hyun
authors.initials: YH
authors.lastname: Ko
authors.forename: Deog Yeon
authors.initials: DY
authors.lastname: Jo
mesh_terms: D000208:Acute Disease; D000368:Aged; D015703:Antigens, CD / Q000097:blood; D018952:Antigens, CD34 / Q000097:blood; D015214:Antigens, Differentiation, Myelomonocytic / Q000097:blood; D001854:Bone Marrow Cells / Q000378:metabolism / Q000473:pathology; D018826:CD13 Antigens / Q000097:blood; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D020440:Gene Duplication; D006684:HLA-DR Antigens / Q000097:blood; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000097:blood / Q000235:genetics* / Q000473:pathology; D016256:Lewis X Antigen / Q000097:blood; D008297:Male; D019009:Proto-Oncogene Proteins c-kit / Q000097:blood; D063268:Sialic Acid Binding Ig-like Lectin 3
chemical_list: D015703:Antigens, CD; D018952:Antigens, CD34; D015214:Antigens, Differentiation, Myelomonocytic; C571163:CD33 protein, human; D006684:HLA-DR Antigens; D016256:Lewis X Antigen; D063268:Sialic Acid Binding Ig-like Lectin 3; D019009:Proto-Oncogene Proteins c-kit; D018826:CD13 Antigens