A 5-year-old boy with unicentric Castleman disease affecting the mesentery: utility of serum IL-6 level and (18)F-FDG PET for diagnosis.
Castleman disease (CD) is a rare lymphoproliferative disorder of unknown etiology. It is quite difficult to diagnose CD without typical localized signs or symptoms. We present a 5-year-old boy with unicentric plasma cell CD in the mesentery, which was too small to be detected by any conventional imaging. (18)F-fluorodeoxyglucose positron emission tomography image and a serum cytokine profile prompted us to perform a curative surgical excision, confirming his diagnosis. Our case also supported an important role of interleukin-6 in the pathophysiology of plasma cell CD.
Toita
Nariaki
N
Department of Pediatrics, Graduate School of Medicine, Japan.
Kawamura
Nobuaki
N
Hatano
Norikazu
N
Takezaki
Syun-ichiro
S
Ohkura
Yuka
Y
Yamada
Masafumi
M
Okano
Motohiko
M
Okada
Tadao
T
Sasaki
Fumiaki
F
Kubota
Kanako C
KC
Itoh
Tomoo
T
Ariga
Tadashi
T
D005871:Castleman Disease / Q000097:blood / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery; D002675:Child, Preschool; D005334:Fever / Q000209:etiology; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D006801:Humans; D015850:Interleukin-6 / Q000097:blood* / Q000235:genetics / Q000502:physiology; D008197:Lymph Node Excision; D008297:Male; D008643:Mesentery / Q000000981:diagnostic imaging*; D010950:Plasma Cells / Q000473:pathology; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals
D005462:Fluorine Radioisotopes; C508600:IL6 protein, human; D015850:Interleukin-6; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18