title: Antibodies induced by dengue virus type 1 and 2 envelope domain III recombinant proteins in monkeys neutralize strains with different genotypes.
abstract: In the present work, we evaluated the neutralizing capacity of the antibodies induced by dengue virus type 1 and 2 envelope domain III recombinant proteins in monkeys against strains of different dengue virus type 1 and 2 genotypes. Here we demonstrated that dengue virus type 1 and 2 recombinant proteins induced high titers of neutralizing antibodies against different genotype strains.
authors.affiliation: Department of Virology, PAHO/WHO Collaborating Center for the Study of Dengue and Its Vector, Pedro Kourí Tropical Medicine Institute, Autopista Novia del Mediodía, km 6 1/2, P.O. Box 601, Marianao 13, Havana, Cuba.
authors.forename: Lidice
authors.initials: L
authors.lastname: Bernardo
authors.forename: Osmel
authors.initials: O
authors.lastname: Fleitas
authors.forename: Alequis
authors.initials: A
authors.lastname: Pavón
authors.forename: Lisset
authors.initials: L
authors.lastname: Hermida
authors.forename: Gerardo
authors.initials: G
authors.lastname: Guillén
authors.forename: Maria G
authors.initials: MG
authors.lastname: Guzman
mesh_terms: D000818:Animals; D057134:Antibodies, Neutralizing / Q000097:blood; D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology*; D003429:Cross Reactions; D003715:Dengue / Q000276:immunology* / Q000821:virology; D053059:Dengue Vaccines / Q000276:immunology*; D003716:Dengue Virus / Q000235:genetics / Q000276:immunology*; D005838:Genotype; D008252:Macaca fascicularis; D009500:Neutralization Tests; D011994:Recombinant Proteins / Q000276:immunology* / Q000378:metabolism; D014759:Viral Envelope Proteins / Q000276:immunology* / Q000378:metabolism
chemical_list: D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral; D053059:Dengue Vaccines; D011994:Recombinant Proteins; D014759:Viral Envelope Proteins