Predictive value of osteocalcin in bone metastatic differentiated thyroid carcinoma.
OBJECTIVE
To evaluate the diagnostic value of serum osteocalcin in the detection of bone metastases from differentiated thyroid carcinoma (DTC).


METHODS
Serum samples from DTC patients with (DTC BM+, n=19) or without bone metastases (DTC BM-, n=19), and matched healthy volunteers (n=30) were tested for serum osteocalcin with electrochemiluminescent immunoassay.


RESULTS
Osteocalcin was higher in DTC BM+ than in DTC BM- patients (+35.8%, p=0.002), acting as an independent risk factor for bone metastases (R(2)=0.142, p=0.039). The sensitivity was 78.9% and the specificity was 63.2% at a cut-off value of 11.2 microg/L.


CONCLUSIONS
Serial measurements of osteocalcin could be useful in the detection of bone metastases from DTC.
Gao
Yunchao
Y
Department of Nuclear Medicine, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, 600 Yishan Road, Shanghai 200233, China. gaookok@163.com
Lu
Hankui
H
Luo
Qiong
Q
Wu
Xiaohui
X
Sheng
Shiwei
S
D000469:Alkaline Phosphatase / Q000097:blood; D014408:Biomarkers, Tumor / Q000097:blood*; D001859:Bone Neoplasms / Q000097:blood / Q000556:secondary; D024042:Collagen Type I / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D015675:Osteocalcin / Q000097:blood*; D011347:Procollagen / Q000097:blood; D013964:Thyroid Neoplasms / Q000097:blood / Q000473:pathology
D014408:Biomarkers, Tumor; D024042:Collagen Type I; D011347:Procollagen; D015675:Osteocalcin; D000469:Alkaline Phosphatase