Polymorphism of HLA-A and HLA-B in pre-eclampsia.
OBJECTIVE
To investigate the association between the polymorphism of HLA-A, HLA-B genes and pre-eclampsia.


METHODS
HLA-A, HLA-B genotyping was performed by polymerase chain reaction sequence-specific primer (PCR-SSP) in 119 preeclampsia patients, 117 normal pregnant women and their neonates.


RESULTS
The study showed that 16 HLA-A and 39 HLA-B alleles were obtained in pre-eclamptic patients and normal pregnant women. 15 HLA-A and 37 HLA-B alleles were obtained in their neonates. No significant difference was found in maternal or neonatal HLA-A, HLA-B alleles between pre-eclampsia group and control group (P(c) > 0.05). The frequencies of HLA-A11, HLA-A24, HLA-B13, HLA-B14, HLA-B15, HLA-B52 maternal/fetus genetic associations were significantly different between pre-eclampsia group and control group (P < 0.05).


CONCLUSIONS
Some HLA-A,HLA-B maternal/fetus special bindings may be associated with the susceptibility or protective of pre-eclampsia.
Zhang
Zhan
Z
Department of Laboratory, The Third Affiliated Hospital, Zhengzhou University, Zhengzhou, 450052, China. zhangzhanmd@yahoo.com.cn
Jia
Li-ting
LT
Zhang
Lin-lin
LL
D000328:Adult; D000483:Alleles; D005260:Female; D056726:Genetic Association Studies; D015234:HLA-A Antigens / Q000235:genetics*; D015235:HLA-B Antigens / Q000235:genetics*; D006801:Humans; D011110:Polymorphism, Genetic / Q000235:genetics*; D011225:Pre-Eclampsia / Q000235:genetics* / Q000276:immunology*; D011247:Pregnancy; D055815:Young Adult
D015234:HLA-A Antigens; D015235:HLA-B Antigens