title: Matrix metalloproteinase-2 inhibitors from Clinopodium chinense var. parviflorum.
abstract: From the aerial parts of Clinopodium chinense var. parviflorum, nine new phenylpropanoids, clinopodic acids A-I (2-10), were isolated together with a known phenylpropanoid, rosmarinic acid (1). The structures of these new compounds were elucidated on the basis of spectroscopic analysis. Clinopodic acid C (4) showed MMP-2 inhibitory activity (IC(50) 3.26 microM).
authors.affiliation: Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan.
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Murata
authors.forename: Kenroh
authors.initials: K
authors.lastname: Sasaki
authors.forename: Kumiko
authors.initials: K
authors.lastname: Sato
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Yoshizaki
authors.forename: Haruna
authors.initials: H
authors.lastname: Yamada
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Mutoh
authors.forename: Kaoru
authors.initials: K
authors.lastname: Umehara
authors.forename: Toshio
authors.initials: T
authors.lastname: Miyase
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Warashina
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Aoshima
authors.forename: Homare
authors.initials: H
authors.lastname: Tabata
authors.forename: Kouichi
authors.initials: K
authors.lastname: Matsubara
mesh_terms: D002934:Cinnamates / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D053630:Depsides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004146:Dioxanes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D007564:Japan; D019686:Lamiaceae / Q000737:chemistry*; D061965:Matrix Metalloproteinase Inhibitors; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D000097123:Rosmarinic Acid
chemical_list: D002934:Cinnamates; D053630:Depsides; D004146:Dioxanes; D061965:Matrix Metalloproteinase Inhibitors; D000097123:Rosmarinic Acid; C543623:clinopodic acid C