title: Taenia crassiceps cysticercosis: variations in its parasite growth permissiveness that encounter with local immune features in BALB/c substrains.
abstract: This study describes the first days of Taenia crassiceps infection in BALB/c substrains, BALB/cAnN and BALB/cJ, using two stocks of the same strains which were kept in different animal facilities, conventional and pathogen-free conditions, respectively. This study shows that parasite growth restriction shown by conventional BALB/cJ mice changed to parasite growth permissiveness when pathogen-free BALB/cJ mice were used. In addition, the higher number of macrophages, NK cells and intraperitoneal level of IFN-gamma found in the conventional restrictive BALB/cJ substrain vanished when the permissiveness to the parasite growth increased. No differences were found in DNA sequences of parasites collected before and after the change in the permissiveness to parasite growth which favors the possibility that the observed modifications could be due to changes in the murine strains and/or their maintenance conditions.
authors.affiliation: Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Apartado Postal 70228, Mexico City C.P. 04510, Mexico.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Meneses
authors.forename: Miriam
authors.initials: M
authors.lastname: Berzunza
authors.forename: Ingeborg
authors.initials: I
authors.lastname: Becker
authors.forename: Raúl J
authors.initials: RJ
authors.lastname: Bobes
authors.forename: Gabriela
authors.initials: G
authors.lastname: Rosas
authors.forename: Edda
authors.initials: E
authors.lastname: Sciutto
authors.forename: Gladis
authors.initials: G
authors.lastname: Fragoso
mesh_terms: D000818:Animals; D003551:Cysticercosis / Q000276:immunology* / Q000469:parasitology; D003552:Cysticercus / Q000235:genetics / Q000254:growth & development* / Q000276:immunology; D018509:DNA, Helminth / Q000737:chemistry; D021901:DNA, Intergenic / Q000737:chemistry; D005260:Female; D005434:Flow Cytometry; D007371:Interferon-gamma / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D010537:Peritoneum / Q000166:cytology / Q000276:immunology; D011110:Polymorphism, Genetic; D013047:Specific Pathogen-Free Organisms
chemical_list: D018509:DNA, Helminth; D021901:DNA, Intergenic; D007371:Interferon-gamma