title: An evaluation of bovine derived xenograft with and without a bioabsorbable collagen membrane in the treatment of mandibular Class II furcation defects.
abstract: BACKGROUND
  The aim of this study was to compare the clinical outcomes of applying Bio-Oss, an anorganic bovine bone xenograft (control group) to the combined use of Bio-Oss and Bio-Gide (a bioabsorbable collagen membrane) (test group) in human mandibular Class II furcation defects.
  
  
  METHODS
  A total of 18 furcations (8 tests and 10 controls) in 14 patients suffering from chronic periodontitis were treated in this randomized clinical trial. Open vertical and horizontal furcation depths (OVFD and OHFD), vertical and horizontal clinical attachment levels (VCAL, HCAL), probing depth (PD) and free gingival marginal level (GML) were among the clinical parameters measured prior and six months after treatment, at re-entry surgery. The data were analysed by statistical tests while a p value less than 0.05 was considered significant.
  
  
  RESULTS
  At the surgical re-entry, the mean reduction for OVFD of the control and test groups was 1.9 +/- 1.3 and 2.1 +/- 1.0, and for OHFD 2.1 +/- 0.7 and 2.4 +/- 1.3, respectively. The control and test treatments resulted in significant reductions in PD, VCAL and HCAL measurements at re-entry but there was no statistically significant difference between the two treatments in all soft and hard tissues measurements.
  
  
  CONCLUSIONS
  This clinical trial failed to demonstrate the superiority of the combined use of Bio-Gide and Bio-Oss to the use of Bio-Oss alone, although both therapies resulted in significant gains in attachment level and bone fill.
authors.affiliation: Department of Periodontics, Mashhad University of Medical Sciences, Dental School and Research Center, Mashhad, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Taheri
authors.forename: R
authors.initials: R
authors.lastname: Molla
authors.forename: M
authors.initials: M
authors.lastname: Radvar
authors.forename: K
authors.initials: K
authors.lastname: Sohrabi
authors.forename: M H
authors.initials: MH
authors.lastname: Najafi
mesh_terms: D020341:Absorbable Implants; D000328:Adult; D000368:Aged; D016301:Alveolar Bone Loss / Q000473:pathology / Q000628:therapy; D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use*; D001857:Bone Matrix / Q000637:transplantation; D018786:Bone Substitutes / Q000627:therapeutic use*; D002417:Cattle; D055113:Chronic Periodontitis / Q000150:complications / Q000628:therapy; D003094:Collagen / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D003753:Dental Health Surveys; D005260:Female; D005500:Follow-Up Studies; D017823:Furcation Defects / Q000209:etiology / Q000473:pathology / Q000628:therapy*; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D006801:Humans; D008297:Male; D008334:Mandible; D008567:Membranes, Artificial; D008875:Middle Aged; D008903:Minerals / Q000627:therapeutic use; D008963:Molar; D017622:Periodontal Attachment Loss / Q000473:pathology / Q000628:therapy; D012720:Severity of Illness Index; D016037:Single-Blind Method; D014092:Tooth Root / Q000473:pathology; D016896:Treatment Outcome
chemical_list: C106416:Bio-Gide; C077540:Bio-Oss; D001672:Biocompatible Materials; D018786:Bone Substitutes; D008567:Membranes, Artificial; D008903:Minerals; D003094:Collagen