A fluorescence "turn-on" ensemble for acetylcholinesterase activity assay and inhibitor screening.
By making use of the aggregation-induced emission feature of compound 1 and the cascade reactions among acetylthiocholine iodide (ATC), AChE, and compound 2, a new fluorescence "turn-on" method is developed for AChE assay and inhibitor-screening.
Peng
Lihua
L
Beijing National Laboratory for Molecular Sciences, Organic Solids Laboratory, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
Zhang
Guanxin
G
Zhang
Deqing
D
Xiang
Junfeng
J
Zhao
Rui
R
Wang
Yilin
Y
Zhu
Daoben
D
D000110:Acetylcholinesterase / Q000378:metabolism*; D000122:Acetylthiocholine / Q000031:analogs & derivatives / Q000737:chemistry; D001555:Benzene Derivatives / Q000737:chemistry; D002800:Cholinesterase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D005453:Fluorescence; D015394:Molecular Structure; D011758:Pyrroles / Q000737:chemistry
D001555:Benzene Derivatives; D002800:Cholinesterase Inhibitors; D011758:Pyrroles; C543539:acetylthiocholine iodide; D000122:Acetylthiocholine; D000110:Acetylcholinesterase