title: Results of "twinning procedure" in lung transplantation: experience in a single center.
abstract: BACKGROUND
  The major limiting factor for lung transplantation (LT), both worldwide and in Spain, is the number of suitable lung donors. This, together with the increased demand for LT, led us to propose the performance of 2 single lung transplantations simultaneously using the same donor (the "twinning procedure").
  
  
  OBJECTIVE
  The objective of this study was to analyze the outcome of patients who underwent transplantation with this procedure, assessing differences between the first and the second transplant.
  
  
  METHODS
  From November 2001 to August 2008, 46 single lung transplantations (SLTs) were performed with 23 donors.
  
  
  RESULTS
  The mean ischemia time was 258 minutes (median, 265) for the first transplantation and 312 minutes (median, 320) for the second transplantation. Primary graft dysfunction occurred in 5 patients (24%) in the first group and 9 in the second group (39%; P = .27). The median intubation time was 8 hours for the first and 6.5 hours for the second group. The mean hospital stay was 39 and 31 days, respectively. Postoperative mortality was 2 (8.7%) and 3 (13%) patient, respectively (P = .99). There was no significant difference in the incidence of acute rejection episodes, infections, or chronic rejections. Five-year survival rates were 67.9% for the first and 61.5% for the second (Kaplan-Meier).
  
  
  CONCLUSIONS
  The performance of 2 SLTs using the same donor and in the same hospital was feasible with adequate planning, permitting better use of donors and reducing waiting list time and mortality. Our results showed no increased risk for recipients of the second transplant in the early postoperative and long-term periods.
authors.affiliation: Thoracic Surgery Department, Complexo Hospitalario Universitario de A Coruña, Spain. mtorre@canalejo.org
authors.forename: M M
authors.initials: MM
authors.lastname: de la Torre
authors.forename: J M
authors.initials: JM
authors.lastname: Borro
authors.forename: R
authors.initials: R
authors.lastname: Fernández
authors.forename: D
authors.initials: D
authors.lastname: González
authors.forename: M
authors.initials: M
authors.lastname: Delgado
authors.forename: M
authors.initials: M
authors.lastname: Paradela
authors.forename: J A
authors.initials: JA
authors.lastname: García
authors.forename: C
authors.initials: C
authors.lastname: Lemos
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006084:Graft Rejection / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D053208:Kaplan-Meier Estimate; D007902:Length of Stay; D016040:Lung Transplantation / Q000009:adverse effects / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013030:Spain; D015996:Survival Rate; D014019:Tissue Donors / Q000600:supply & distribution*