title: High-intensity focused ultrasound with large scale spherical phased array for the ablation of deep tumors.
abstract: Under some circumstances surgical resection is feasible in a low percentage for the treatment of deep tumors. Nevertheless, high-intensity focused ultrasound (HIFU) is beginning to offer a potential noninvasive alternative to conventional therapies for the treatment of deep tumors. In our previous study, a large scale spherical HIFU-phased array was developed to ablate deep tumors. In the current study, taking into account the required focal depth and maximum acoustic power output, 90 identical circular PZT-8 elements (diameter =1.4 cm and frequency=1 MHz) were mounted on a spherical shell with a radius of curvature of 18 cm and a diameter of 21 cm. With the developed array, computer simulations and ex vivo experiments were carried out. The simulation results theoretically demonstrate the ability of the array to focus and steer in the specified volume (a 2 cmx2 cmx3 cm volume) at the focal depth of 15 to 18 cm. Ex vivo experiment results also verify the capability of the developed array to ablate deep target tissue by either moving single focal point or generating multiple foci simultaneously.
authors.affiliation: Department of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Ji
authors.forename: Jing-feng
authors.initials: JF
authors.lastname: Bai
authors.forename: Guo-feng
authors.initials: GF
authors.lastname: Shen
authors.forename: Ya-zhu
authors.initials: YZ
authors.lastname: Chen
mesh_terms: D000818:Animals; D003198:Computer Simulation; D004867:Equipment Design; D019544:Equipment Failure Analysis; D019220:High-Energy Shock Waves / Q000627:therapeutic use*; D066298:In Vitro Techniques; D008954:Models, Biological; D018482:Muscle, Skeletal / Q000473:pathology* / Q000528:radiation effects*; D013552:Swine; D014159:Transducers; D014464:Ultrasonic Therapy / Q000295:instrumentation* / Q000379:methods