Copper-catalyzed enantioselective carbenoid insertion into S-H bonds.
An asymmetric carbenoid insertion into S-H bonds catalyzed by copper-chiral spiro bisoxazoline complexes has been developed, in which a series of alpha-mercaptoesters were produced in high yields with moderate to good enantioselectivities (up to 85% ee); this result represents the best enantioselectivity in the catalytic asymmetric carbenoid S-H bond insertion reaction.
Zhang
Yong-Zhen
YZ
State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China.
Zhu
Shou-Fei
SF
Cai
Yan
Y
Mao
Hong-Xiang
HX
Zhou
Qi-Lin
QL