title: Two new cerebrosides from the pollen of Typha angustifolia.
abstract: Two new cerebrosides, 1-O-(beta-d-glucopyranosyloxy)-(2S,3S,4R,8Z)-2-[(2'R)-2'-hydroxytricosanoylamino]-8-nonadecene-3,4-diol (1) and 1-O-(beta-D-glucopyranosyloxy)-(2S,3R,4E,8Z)-2-[(2'R)-2'-hydroxynonadecanoylamino]-4,13-nonadecene-3-diol (2), were isolated from the pollen of Typha angustifolia. Their structures were elucidated by chemical and spectral means. This is the first report on the occurrence of cerebroside in Typha (Typhaceae). Compounds 1 and 2 exhibited effect on the proliferation of cultured vascular smooth muscle cell (VSMCs) induced by fatal bovine serum (FBS).
authors.affiliation: Jiangsu Key Laboratory for TCM Formulae Research, Nanjing University of Chinese Medicine, Nanjing, China.
authors.forename: Wei-Wei
authors.initials: WW
authors.lastname: Tao
authors.forename: Nian-Yun
authors.initials: NY
authors.lastname: Yang
authors.forename: Li
authors.initials: L
authors.lastname: Liu
authors.forename: Jin-Ao
authors.initials: JA
authors.lastname: Duan
authors.forename: De-Kang
authors.initials: DK
authors.lastname: Wu
authors.forename: Da-Wei
authors.initials: DW
authors.lastname: Qian
authors.forename: Yu-Ping
authors.initials: YP
authors.lastname: Tang
mesh_terms: D000818:Animals; D001161:Arteriosclerosis / Q000517:prevention & control; D002317:Cardiovascular Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002417:Cattle; D049109:Cell Proliferation / Q000187:drug effects; D002554:Cerebrosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D042783:Endothelial Cells / Q000187:drug effects; D004730:Endothelium, Vascular / Q000187:drug effects*; D005963:Glucosylceramides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D011058:Pollen / Q000737:chemistry; D032401:Typhaceae / Q000737:chemistry*
chemical_list: C551162:1-O-(glucopyranosyloxy)-2-(2'-hydroxynonadecanoylamino)-4,13-nonadecene-3-diol; C551161:1-O-(glucopyranosyloxy)-2-(2'-hydroxytricosanoylamino)-8-nonadecene-3,4-diol; D002317:Cardiovascular Agents; D002554:Cerebrosides; D005963:Glucosylceramides; D010936:Plant Extracts