title: Expression of stanniocalcin-1 in gastrointestinal tracts of neonatal and mature rats.
abstract: Stanniocalcin-1 (STC-1) produced by ovaries endocrinologically targets to mammary glands and is secreted into milk during lactation. The decline of mother's serum level by STC-1 antiserum administration reduced the milk fat content and the pups' body fat content. Nevertheless, the pups' fecal fat content was increased, suggesting that milk-derived STC-1 could influence intestinal fat absorption. We investigated the STC-1 expression in rat gastrointestinal tissues using immunocytochemistry and in situ hybridization. STC-1 was widely expressed in the chief cells of gastric pits and the cells of intestinal glands. Goblet cells in the small intestine contained STC-1 protein in their mucus. The distribution shows that this peptide is secreted exocrinologically into the gastrointestinal lumen. Quantitative RT-PCR analysis revealed that the expression ratio was higher in the periods of heavy nutritional demand, such as growing and lactation. The endogenous STC-1, similar to milk-derived STC-1, may be involved in digestion and/or absorption in gastrointestinal organs.
authors.affiliation: Department of Pediatrics, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi, Japan.
authors.forename: Rika
authors.initials: R
authors.lastname: Kobayashi
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Nakagomi
authors.forename: Yoshie
authors.initials: Y
authors.lastname: Shimura
authors.forename: Mie
authors.initials: M
authors.lastname: Mochizuki
authors.forename: Kisho
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Kanji
authors.initials: K
authors.lastname: Sugita
authors.forename: Kenji
authors.initials: K
authors.lastname: Ohyama
mesh_terms: D000367:Age Factors; D000818:Animals; D005260:Female; D041981:Gastrointestinal Tract / Q000378:metabolism*; D006023:Glycoproteins / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007668:Kidney / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D006023:Glycoproteins; C051795:teleocalcin