title: Psoriasis may not be an independent predictor for the use of cardiovascular and anti-diabetic drugs: a 5-year prevalence study.
abstract: Most studies investigating the association between psoriasis and cardiovascular disease have shown a significant relationship. This comparison study investigated the association between psoriasis and prevalent use of cardiovascular drugs. Drug exposure data for 1998 to 2006 were extracted from the Dutch PHARMO-Record Linkage System database. Psoriasis patients were selected using an algorithm of hospitalization and drug dispensing records specific for psoriasis and matched with controls for gender, age and time-period. From the records of 2.5 million Dutch residents, 9,804 (0.4%) psoriasis patients and 15,288 (0.6%) controls were selected. Psoriasis patients used significantly more anti-hypertensives, anti-coagulant and anti-platelet agents, digoxin, nitrates, lipid-lowering and anti-diabetic drugs than the reference population during a 5-year period observation. In a multiple linear regression model adjusting for the number of unique drugs used, psoriasis was no longer significantly associated with any of these drug classes. Psoriasis patients used more cardiovascular-related drugs, but surveillance bias appears to affect this association considerably.
authors.affiliation: Department of Dermatology, Erasmus University Medical Centre, Rotterdam, The Netherlands.
authors.forename: Marlies
authors.initials: M
authors.lastname: Wakkee
authors.forename: Willemijn
authors.initials: W
authors.lastname: Meijer
authors.forename: H A Martino
authors.initials: HA
authors.lastname: Neumann
authors.forename: Ron M C
authors.initials: RM
authors.lastname: Herings
authors.forename: Tamar
authors.initials: T
authors.lastname: Nijsten
mesh_terms: D000328:Adult; D002317:Cardiovascular Agents / Q000627:therapeutic use*; D002318:Cardiovascular Diseases / Q000188:drug therapy* / Q000209:etiology; D016022:Case-Control Studies; D019992:Databases as Topic; D003879:Dermatologic Agents / Q000627:therapeutic use; D003920:Diabetes Mellitus / Q000188:drug therapy* / Q000209:etiology; D011307:Drug Prescriptions; D004363:Drug Utilization; D005260:Female; D006760:Hospitalization; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009426:Netherlands; D016017:Odds Ratio; D011565:Psoriasis / Q000150:complications* / Q000188:drug therapy; D018570:Risk Assessment; D012307:Risk Factors; D012720:Severity of Illness Index; D013997:Time Factors
chemical_list: D002317:Cardiovascular Agents; D003879:Dermatologic Agents; D007004:Hypoglycemic Agents