title: Dacarbazine as single-agent therapy for relapsed lymphoma in dogs.
abstract: BACKGROUND
  Multidrug resistance is the most common cause of treatment failure in dogs with multicentric lymphoma. 5-(3,3-Dimethyl-1-triazeno)-imidazole-4-carboxamide (DTIC) is an atypical alkylator used as standard treatment in human Hodgkin's lymphoma, and has been effective in combination treatment to treat resistant lymphoma in dogs. However, no data are available on the use of DTIC as a single agent in the treatment of relapsed canine lymphoma.
  
  
  OBJECTIVE
  Single-agent DTIC is effective and safe in treating dogs with lymphoma that relapsed or failed to respond to previous chemotherapy.
  
  
  METHODS
  Forty client-owned dogs with relapsed lymphoma.
  
  
  METHODS
  Dogs were eligible for the retrospective study if they had a histologically or cytologically confirmed diagnosis of lymphoma and had relapsed. Dogs received DTIC (800-1,000 mg/m(2) every 2-3 weeks as a 4-5-hour IV infusion) and were evaluated for response rate and duration. Hematologic and gastrointestinal toxicity was assessed.
  
  
  RESULTS
  The overall response rate for dogs being treated with DTIC was 35% (14 dogs) with a median progression-free interval of 43 days. Thirteen dogs had a partial response and 1 dog had a complete response. Stable disease was achieved in 3 dogs. Mild gastrointestinal toxicity was reported in 3 dogs posttreatment. Thrombocytopenia was the principal toxicity observed 7-14 days after the treatment. Treatments were delayed because of thrombocytopenia.
  
  
  CONCLUSIONS
  DTIC, when used alone, is effective in the treatment of dogs with relapsed lymphoma.
authors.affiliation: Harrington Oncology Program, Cummings School of Veterinary Medicine at Tufts University, North Grafton, MA, USA. pascaleg@vet.upenn.edu
authors.forename: P C
authors.initials: PC
authors.lastname: Griessmayr
authors.forename: S E
authors.initials: SE
authors.lastname: Payne
authors.forename: J E
authors.initials: JE
authors.lastname: Winter
authors.forename: L G
authors.initials: LG
authors.lastname: Barber
authors.forename: F S
authors.initials: FS
authors.lastname: Shofer
mesh_terms: D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use*; D003606:Dacarbazine / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D005260:Female; D008223:Lymphoma / Q000188:drug therapy / Q000662:veterinary*; D008297:Male; D012008:Recurrence; D012189:Retrospective Studies
chemical_list: D018906:Antineoplastic Agents, Alkylating; D003606:Dacarbazine