Comparison of metformin treatment and laparoscopic ovarian diathermy in patients with polycystic ovary syndrome.
OBJECTIVE
To compare hormone levels and clinical outcomes in patients with polycystic ovary syndrome (PCOS) after metformin therapy or laparoscopic ovarian diathermy (LOD) at 6 months follow-up.


METHODS
A randomized trial was conducted in 126 patients with PCOS who had a history of infertility for at least 1 year and resistance to clomiphene citrate (CC). Patients (n=63) received metformin treatment or underwent LOD (n=63).


RESULTS
Levels of follicle-stimulating hormone did not change in either group after the intervention (P>0.05). Serum levels of testosterone (P<0.001) and luteinizing hormone (P<0.001) were significantly lower after the treatment in both groups. The proportion of women with regular menstrual cycles increased significantly to 35% (P<0.001) in the LOD group and to 49% (P<0.001) in metformin group compared with before the intervention. Although proportion was higher in the metformin group compared with the LOD group, the difference was not significant (odds ratio 1.81; 95% CI, 0.88-3.69, P=0.1). Hirsutism decreased significantly from 100% to 79.37% (P<0.001) in both groups.


CONCLUSIONS
CC-resistant patients with PCOS were treated effectively by both metformin and LOD.
Ashrafinia
Mansoor
M
Department of Gynecology and Obstetrics, Roointan-Arash Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Hosseini
Reihaneh
R
Moini
Ashraf
A
Eslami
Bita
B
Asgari
Zahra
Z
D000328:Adult; D002996:Clomiphene / Q000627:therapeutic use; D003972:Diathermy; D005260:Female; D005300:Fertility Agents, Female / Q000627:therapeutic use; D006628:Hirsutism / Q000517:prevention & control; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007247:Infertility, Female / Q000209:etiology; D010535:Laparoscopy; D007986:Luteinizing Hormone / Q000097:blood; D008597:Menstrual Cycle / Q000097:blood; D008687:Metformin / Q000627:therapeutic use*; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000188:drug therapy* / Q000601:surgery*; D013739:Testosterone / Q000097:blood; D055815:Young Adult
D005300:Fertility Agents, Female; D007004:Hypoglycemic Agents; D002996:Clomiphene; D013739:Testosterone; D007986:Luteinizing Hormone; D008687:Metformin