Conidiobolomycosis in relapsed acute lymphoblastic leukemia.
Invasive fungal infections in immunocompromised children suffering from hematological malignancies have been a major cause of morbidity and mortality. In recent years fungi other than aspergillus and candida are gaining importance. These emerging fungal infections have distinct epidemiological features and management issues especially in immunocompromised patients. Here we report the isolation of Conidiobolus coronatus, a rarely reported zygomycetes infection in a patient suffering from acute lymphoblastic leukemia. Conidiobolus generally causes indolent infection in the sino-respiratory tract. They are known to be angioinvasive and can disseminate. There is no consensus regarding appropriate antifungal treatment for Conidiobolus infection.
Radhakrishnan
Nita
N
Pediatric Hematology Oncology and BMT Unit, Department of Pediatrics, Sir Ganga Ram Hospital, Rajinder Nagar, New Delhi, India.
Sachdeva
Anupam
A
Oberoi
Jaswinder
J
Yadav
Satya Prakash
SP
D000666:Amphotericin B / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D001215:Asparaginase / Q000008:administration & dosage / Q000009:adverse effects; D002648:Child; D003131:Combined Modality Therapy; D020092:Conidiobolus / Q000302:isolation & purification*; D003646:Debridement; D003907:Dexamethasone / Q000008:administration & dosage / Q000009:adverse effects; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D015523:Maxillary Sinusitis / Q000188:drug therapy / Q000209:etiology* / Q000382:microbiology / Q000601:surgery; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects; D054517:Orbital Cellulitis / Q000188:drug therapy / Q000209:etiology* / Q000382:microbiology; D010198:Pancytopenia / Q000139:chemically induced; D054218:Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000188:drug therapy; D012008:Recurrence; D014750:Vincristine / Q000008:administration & dosage / Q000009:adverse effects; D020096:Zygomycosis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000382:microbiology / Q000601:surgery
D014750:Vincristine; D003907:Dexamethasone; D000666:Amphotericin B; D001215:Asparaginase; D008727:Methotrexate