Association between markers of inflammation, fibrosis and hypervolemia in peritoneal dialysis patients.
OBJECTIVE
Volume expansion in peritoneal dialysis (PD) patients is associated with left ventricular hypertrophy. The link between inflammation and hypervolemia has not been extensively studied. The aim of this study was to determine if an association exists between hypervolemia and markers of inflammation in PD patients.


METHODS
In this cross-sectional study of 22 prevalent PD patients, volume was determined by bioelectrical impedance analysis. Serum and peritoneal effluent interleukin-6 (IL-6) and peritoneal transforming growth factor (TGF)-beta(1) were measured. A fast peritoneal equilibration test determined peritoneal transport status.


RESULTS
Bioimpedance-derived measures of hypervolemia correlated with peritoneal effluent IL-6 and TGF-beta(1). Peritoneal IL-6 was also associated with high peritoneal transport status.


CONCLUSIONS
Markers of inflammation and fibrosis (peritoneal IL-6 and TGF-beta(1)) are associated with markers of hypervolemia.
Gangji
Azim S
AS
Division of Nephrology, McMaster University and St. Joseph's Healthcare, Hamilton, Ont., Canada.
Brimble
K Scott
KS
Margetts
Peter J
PJ
D015415:Biomarkers / Q000032:analysis; D001810:Blood Volume; D003430:Cross-Sectional Studies; D005355:Fibrosis / Q000175:diagnosis* / Q000209:etiology; D006801:Humans; D007249:Inflammation / Q000175:diagnosis* / Q000209:etiology; D015850:Interleukin-6 / Q000032:analysis; D008875:Middle Aged; D010530:Peritoneal Dialysis; D010537:Peritoneum / Q000737:chemistry / Q000473:pathology; D051436:Renal Insufficiency, Chronic / Q000473:pathology*; D053773:Transforming Growth Factor beta1 / Q000032:analysis
D015415:Biomarkers; D015850:Interleukin-6; D053773:Transforming Growth Factor beta1