Treprostinil to reverse pulmonary hypertension associated with idiopathic pulmonary fibrosis as a bridge to single-lung transplantation.
The available therapies and prognosis of idiopathic pulmonary fibrosis remain relatively poor, and concurrent pulmonary hypertension further increases the risk of death and complications after lung transplantation. Limited data exist for the treatment of pulmonary hypertension associated with idiopathic pulmonary fibrosis. We describe a case where intravenous treprostinil was used to bridge an elderly patient with idiopathic pulmonary fibrosis with severe pulmonary hypertension to successful single-lung transplantation.
Saggar
Rajeev
R
Division of Pulmonary and Critical Care Medicine, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California 90095-1690, USA. rasaggar@mednet.ucla.edu
Shapiro
Shelley S
SS
Ross
David J
DJ
Fishbein
Michael C
MC
Zisman
David A
DA
Lynch
Joseph P
JP
Weigt
Sam S
SS
Ardehali
Abbas
A
Belperio
John A
JA
Saggar
Rajan
R
D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D011464:Epoprostenol / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000601:surgery*; D054990:Idiopathic Pulmonary Fibrosis / Q000150:complications* / Q000000981:diagnostic imaging / Q000601:surgery*; D016040:Lung Transplantation / Q000379:methods*; D010879:Piperazines / Q000627:therapeutic use; D011687:Purines / Q000627:therapeutic use; D000068677:Sildenafil Citrate; D013147:Spirometry; D013450:Sulfones / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000627:therapeutic use
D000959:Antihypertensive Agents; D010879:Piperazines; D011687:Purines; D013450:Sulfones; D014665:Vasodilator Agents; D000068677:Sildenafil Citrate; D011464:Epoprostenol; C427248:treprostinil