title: Adiponectin and testosterone in patients with symptoms of late-onset hypogonadism: is there a link?
abstract: OBJECTIVE
  To examine the correlation between testosterone and adiponectin in symptomatic late-onset hypogonadism (LOH) patients.
  
  
  METHODS
  The study included 174 patients (>40 years old) with at least one LOH symptom and an Aging Male Symptoms score >26. The correlation between serum adiponectin levels and various factors was investigated by simple and multiple regression analyses. Serum adiponectin levels before and after testosterone replacement therapy (TRT) in 43 patients with serum free testosterone <11.8 pg/mL were also compared.
  
  
  RESULTS
  Serum adiponectin levels increased with increased age (P < 0.01), decreased with increased body mass index (P < 0.01), and increased with increased sex hormone-binding globulin (P < 0.01). Multiple regression analysis revealed that body mass index and sex hormone-binding globulin were factors with an influence on serum adiponectin levels. However, no association between testosterone and adiponectin was found. In the 43 patients receiving TRT, serum adiponectin levels before and after TRT did not differ significantly.
  
  
  CONCLUSIONS
  Serum adiponectin is not related to serum testosterone in symptomatic LOH patients, suggesting that TRT in these subjects does not pose a higher risk of inducing a metabolic syndrome.
authors.affiliation: Department of Urology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan. akitsuji@uro.med.osakau.ac.jp
authors.forename: Akira
authors.initials: A
authors.lastname: Tsujimura
authors.forename: Shingo
authors.initials: S
authors.lastname: Takada
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Matsuoka
authors.forename: Jiro
authors.initials: J
authors.lastname: Nakayama
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Takao
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Miyagawa
authors.forename: Mina
authors.initials: M
authors.lastname: Sonoda
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Nishizawa
authors.forename: Hiromi
authors.initials: H
authors.lastname: Iwahashi
authors.forename: Tohru
authors.initials: T
authors.lastname: Funahashi
authors.forename: Norio
authors.initials: N
authors.lastname: Nonomura
authors.forename: Akihiko
authors.initials: A
authors.lastname: Okuyama
mesh_terms: D052242:Adiponectin / Q000097:blood* / Q000502:physiology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D007006:Hypogonadism / Q000097:blood* / Q000188:drug therapy / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D013739:Testosterone / Q000097:blood* / Q000502:physiology / Q000627:therapeutic use
chemical_list: D052242:Adiponectin; D013739:Testosterone