Pharmacokinetics of moxifloxacin in cerebrospinal fluid and plasma in patients with tuberculous meningitis.
Moxifloxacin cerebrospinal fluid (CSF) penetration was evaluated by obtaining full plasma and CSF time concentration curves for 4 patients with tuberculous meningitis. The geometric mean ratio of the areas under the curve for CSF to plasma were 0.82 (range, 0.70-0.94) at 400 mg once per day and 0.71 (0.58-0.84) at 800 mg once per day.
Alffenaar
J W C
JW
Department of Hospital and Clinical Pharmacy, University Medical Center Groningen, PO Box 30.001, 9700 RB Groningen, the Netherlands. j.w.c.alffenaar@apoth.umcg.nl
van Altena
R
R
Bökkerink
H J
HJ
Luijckx
G J
GJ
van Soolingen
D
D
Aarnoutse
R E
RE
van der Werf
T S
TS
D000328:Adult; D000368:Aged; D000995:Antitubercular Agents / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D019540:Area Under Curve; D001372:Aza Compounds / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D002555:Cerebrospinal Fluid / Q000737:chemistry*; D024841:Fluoroquinolones; D006801:Humans; D008297:Male; D008875:Middle Aged; D000077266:Moxifloxacin; D010949:Plasma / Q000737:chemistry*; D011804:Quinolines / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D013997:Time Factors; D014390:Tuberculosis, Meningeal / Q000188:drug therapy*
D000995:Antitubercular Agents; D001372:Aza Compounds; D024841:Fluoroquinolones; D011804:Quinolines; D000077266:Moxifloxacin