title: Highly chemoselective copper-catalyzed conjugate reduction of stereochemically labile alpha,beta-unsaturated amino ketones.
abstract: Highly chemoselective conjugate reduction of chiral alpha,beta-unsaturated amino ketones has been developed by using triisopropyl phosphite ligated copper hydride complex. The highlights of the method are wide substrate compatibility and exceptional chemoselectivity.
authors.affiliation: Department of Chemistry, Helsinki University of Technology, P.O. Box 6100, FIN-02015 HUT, Espoo, Finland.
authors.forename: Andrejs
authors.initials: A
authors.lastname: Pelss
authors.forename: Esa T T
authors.initials: ET
authors.lastname: Kumpulainen
authors.forename: Ari M P
authors.initials: AM
authors.lastname: Koskinen
mesh_terms: D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D007659:Ketones; D009942:Organometallic Compounds; D003300:Copper