Role of the medulla oblongata in normal and high arterial blood pressure regulation: the contribution of Escola Paulista de Medicina - UNIFESP.
Several forms of experimental evidence gathered in the last 37 years have unequivocally established that the medulla oblongata harbors the main neural circuits responsible for generating the vasomotor tone and regulating arterial blood pressure. Our current understanding of this circuitry derives mainly from the studies of Pedro Guertzenstein, a former student who became Professor of Physiology at UNIFESP later, and his colleagues. In this review, we have summarized the main findings as well as our collaboration to a further understanding of the ventrolateral medulla and the control of arterial blood pressure under normal and pathological conditions.
Cravo
Sergio L
SL
Departamento de Fisiologia, Universidade Federal de São Paulo, São Paulo, SP, Brasil. sldcravo@fcr.epm.br
Campos
Ruy R
RR
Colombari
Eduardo
E
Sato
Mônica A
MA
Bergamaschi
Cássia M
CM
Pedrino
Gustavo R
GR
Ferreira-Neto
Marcos L
ML
Lopes
Oswaldo U
OU
D000818:Animals; D017704:Baroreflex / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology*; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D008526:Medulla Oblongata / Q000502:physiology*; D051381:Rats; D013564:Sympathetic Nervous System / Q000502:physiology*; D014666:Vasomotor System / Q000502:physiology*