A powerful reagent for synthesis of Weinreb amides directly from carboxylic acids.
A powerful reagent, P[NCH(3)(OCH(3))](3) (3), for conversion of carboxylic acids directly to Weinreb amides was developed. In most cases the yields of the corresponding Weinreb amides were above 90% when P[NCH(3)(OCH(3))](3) was heated with aromatic and aliphatic carboxylic acids in toluene. The sterically hindered carboxylic acids can also give the corresponding Weinreb amides in excellent yields.
Niu
Teng
T
College of Chemistry and Chemical Engineering, Northwest Normal University, 967 Anning Road (E.), Lanzhou 730070, PR China.
Zhang
Weiming
W
Huang
Danfeng
D
Xu
Changming
C
Wang
Haifeng
H
Hu
Yulai
Y
D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D002264:Carboxylic Acids / Q000737:chemistry*; D015394:Molecular Structure; D009943:Organophosphorus Compounds / Q000737:chemistry*; D013237:Stereoisomerism
D000577:Amides; D002264:Carboxylic Acids; D009943:Organophosphorus Compounds; C545157:P(NCH3(OCH3))3