Biscarpamontamines A and B, an aspidosperma-iboga bisindole alkaloid and an aspidosperma-aspidosperma bisindole alkaloid, from Tabernaemontana sphaerocarpa.
Two new bisindole alkaloids, biscarpamontamine A (1), possessing an aspidosperma-iboga-type skeleton, and biscarpamontamine B (2), having an aspidosperma-aspidosperma-type skeleton, were isolated from stems of Tabernaemontana sphaerocarpa, and their structures were elucidated on the basis of spectroscopic data analysis. The absolute configuration of biscarpamontamine B (2) was established by comparison of its CD spectrum and with that of vobtusine (3). Biscarpamontamine B (2) showed potent cytotoxicity against various human cancer cell lines.
Zaima
Kazumasa
K
Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa, Tokyo, Japan.
Hirata
Tomoko
T
Hosoya
Takahiro
T
Hirasawa
Yusuke
Y
Koyama
Koichiro
K
Rahman
Abdul
A
Kusumawati
Idha
I
Zaini
Noor Cholies
NC
Shiro
Motoo
M
Morita
Hiroshi
H
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D030009:Aspidosperma / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D045325:HCT116 Cells; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007214:Indonesia; D015394:Molecular Structure; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D030014:Tabernaemontana / Q000737:chemistry*
D000972:Antineoplastic Agents, Phytogenic; D026121:Indole Alkaloids; C544369:biscarpamontamine A; C544370:biscarpamontamine B