title: The effect of combined tobramycin-clarithromycin on Mycobacterium tuberculosis isolates.
abstract: This study investigated the susceptibility of 25 Mycobacterium tuberculosis clinical isolates to tobramycin (TBM) and clarithromycin (CLM). The effect of the drugs administered together was examined for possible synergistic effect. The median minimum inhibitory concentration (MIC) for both drugs was 8 mug/ml. In 36% of the isolates, a decrease of the CLM MIC by a single or two-fold dilution was observed when a sub-inhibitory concentration of TBM was added. The results suggest that both drugs should be investigated further as potential adjuncts to the treatment of resistant tuberculosis, in particular through new drug delivery systems such as the dry powder inhaler allowing high lung deposition.
authors.affiliation: Reference Laboratory of Tuberculosis and Mycobacteria, Scientific Institute of Public Health, Department Institut Pasteur, Brussels, Belgium.
authors.forename: K
authors.initials: K
authors.lastname: Stoffels
authors.forename: H
authors.initials: H
authors.lastname: Traore
authors.forename: F
authors.initials: F
authors.lastname: Vanderbist
authors.forename: M
authors.initials: M
authors.lastname: Fauville-Dufaux
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D017291:Clarithromycin / Q000008:administration & dosage*; D004352:Drug Resistance, Microbial; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D014031:Tobramycin / Q000008:administration & dosage*
chemical_list: D000900:Anti-Bacterial Agents; D017291:Clarithromycin; D014031:Tobramycin