Matrix metalloproteinase-2 inhibitors from Clinopodium chinense var. parviflorum.
From the aerial parts of Clinopodium chinense var. parviflorum, nine new phenylpropanoids, clinopodic acids A-I (2-10), were isolated together with a known phenylpropanoid, rosmarinic acid (1). The structures of these new compounds were elucidated on the basis of spectroscopic analysis. Clinopodic acid C (4) showed MMP-2 inhibitory activity (IC(50) 3.26 microM).
Murata
Toshihiro
T
Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan.
Sasaki
Kenroh
K
Sato
Kumiko
K
Yoshizaki
Fumihiko
F
Yamada
Haruna
H
Mutoh
Hiromichi
H
Umehara
Kaoru
K
Miyase
Toshio
T
Warashina
Tsutomu
T
Aoshima
Hiroaki
H
Tabata
Homare
H
Matsubara
Kouichi
K
D002934:Cinnamates / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D053630:Depsides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004146:Dioxanes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D007564:Japan; D019686:Lamiaceae / Q000737:chemistry*; D061965:Matrix Metalloproteinase Inhibitors; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D000097123:Rosmarinic Acid
D002934:Cinnamates; D053630:Depsides; D004146:Dioxanes; D061965:Matrix Metalloproteinase Inhibitors; D000097123:Rosmarinic Acid; C543623:clinopodic acid C