title: Evaluation of the severity of mitral regurgitation by the use of signal void in magnetic resonance imaging.
abstract: BACKGROUND
  The study was designed to evaluate the severity of mitral regurgitation by cardiac magnetic resonance imaging (MRI). We proposed a new measurement of signal void by MRI and tried to define threshold values for the severity of regurgitation with different sequences.
  
  
  METHODS
  Twenty-one patients with mitral regurgitation were evaluated by echocardiography and MRI. We measured the length, width, and the area of jet flow void from long-axis and four-chamber views. The regurgitant area was measured with TrueFISP, FLASH sequences, and phase images by tracing the signal-void area in left atrium parallel to mitral annulus. This new parameter for grading of the severity of mitral regurgitation by cine MRI was called regurgitant area from short axis (RAFSA).
  
  
  RESULTS
  All methods (EROA, vena contracta) were correlated for determining the regurgitation severity (P < 0.01). There was a correlation between EROA by echocardiography and RAFSA by MRI with the TrueFISP, FLASH sequences, and phase images (P < 0.01). Stepwise regression analysis revealed that EROA was significantly correlated with RAFSA by phase images (P < 0.001). After regression analysis, threshold values of RAFSA by phase imaging were calculated and found to be 0.27 cm(2) and 0.92 cm(2) between mild, moderate, and severe mitral regurgitations (100% sensitivity, 67% specificity, and 100% sensitivity, 78% specificity, respectively) (P < 0.01, P < 0.05).
  
  
  CONCLUSIONS
  MRI is an alternative method for evaluating mitral regurgitation. Our study suggests a new parameter, RAFSA by cine MRI, to grade the severity of mitral regurgitation and provides threshold values in order to define mild, moderate, and severe regurgitations.
authors.affiliation: Cardiology Department, Tepecik Training and Research Hospital, Izmir, Turkey. onerozdogan@yahoo.com
authors.forename: Oner
authors.initials: O
authors.lastname: Ozdogan
authors.forename: Alper
authors.initials: A
authors.lastname: Yuksel
authors.forename: Cemil
authors.initials: C
authors.lastname: Gurgun
authors.forename: Meral
authors.initials: M
authors.lastname: Kayikcioglu
authors.forename: Oguz
authors.initials: O
authors.lastname: Yavuzgil
authors.forename: Cahide Soydas
authors.initials: CS
authors.lastname: Cinar
mesh_terms: D000328:Adult; D000465:Algorithms; D004452:Echocardiography / Q000379:methods; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods*; D008297:Male; D008944:Mitral Valve Insufficiency / Q000175:diagnosis*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity