Administration of high-dose interleukin-2 in a 2-year-old with metastatic melanoma.
Malignant melanoma is rare in pediatrics, and therapies for patients with disseminated disease have not been well studied. This report describes our experience with the use of high-dose interleukin 2 (aldesleukin, IL-2) in a 2-year-old child with metastatic melanoma and describes our approach for the administration of this agent to young patients.
Bernhardt
M Brooke
MB
Department of Pharmacy, Texas Children's Hospital, Houston, Texas 77030, USA. mbbernha@texaschildrens.org
Hicks
M John
MJ
Pappo
Alberto S
AS
D000700:Analgesics / Q000008:administration & dosage / Q000627:therapeutic use; D000740:Anemia / Q000139:chemically induced; D000930:Antidiarrheals / Q000008:administration & dosage / Q000627:therapeutic use; D000932:Antiemetics / Q000008:administration & dosage / Q000627:therapeutic use; D002637:Chest Pain / Q000139:chemically induced; D003131:Combined Modality Therapy; D017809:Fatal Outcome; D005260:Female; D005440:Fluid Therapy; D006801:Humans; D007022:Hypotension / Q000139:chemically induced; D007155:Immunologic Factors / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D007223:Infant; D007262:Infusions, Intravenous; D007372:Interferons / Q000627:therapeutic use*; D007376:Interleukin-2 / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D008545:Melanoma / Q000188:drug therapy / Q000556:secondary* / Q000601:surgery; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy*; D011292:Premedication; D011654:Pulmonary Edema / Q000139:chemically induced; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000601:surgery
D000700:Analgesics; D000930:Antidiarrheals; D000932:Antiemetics; D007155:Immunologic Factors; D007376:Interleukin-2; D007372:Interferons