Toward efficient palladium-catalyzed allylic C-H alkylation.
Recent breakthroughs have proved that direct palladium(II)-catalyzed allylic C-H alkylation can be achieved. This new procedure shows that the inherent requirement for a leaving group in the Tsuji-Trost palladium-catalyzed allylic alkylation can be lifted. These initial reports hold great promise for the development of allylic C-H alkylation into a widely applicable methodology, thus providing a means to enhance synthetic efficiency in these reactions.
Jensen
Thomas
T
Department of Chemistry, Technical University of Denmark, Kemitorvet, building 207, Denmark.
Fristrup
Peter
P