[In vitro efficacy of ingavirin against the Mexican pandemic subtype H1N1 of influenza A virus, strains A/California/04/2009 and A/California/07/2009].
Ingavirin was shown to be efficient in inhibition of the influenza virus strains A/California/04/2009 and A/California/07/2009 (H1N1) in the MDCK cell culture. The coefficient of the cytopathic activity inhibition amounted to 50 and 60%, and the inhibition coefficients of the specific hemagglutinin formation were 50 and 50%, and 79,1 and 75% before and after the enrichment in chick embryos respectively.
Loginova
S Ia
SIa
Borisevich
S V
SV
Lykov
M V
MV
Vedenina
E V
EV
Borisevich
G V
GV
Bondarev
V P
VP
Nebol'sin
V E
VE
Chuchalin
A G
AG
D000577:Amides / Q000494:pharmacology*; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002208:Caproates; D002460:Cell Line; D002642:Chick Embryo; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D003998:Dicarboxylic Acids / Q000494:pharmacology*; D004196:Disease Outbreaks; D004285:Dogs; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology*; D053118:Influenza A Virus, H1N1 Subtype / Q000187:drug effects* / Q000502:physiology; D007251:Influenza, Human / Q000453:epidemiology* / Q000821:virology*; D008800:Mexico / Q000453:epidemiology; D009976:Orthomyxoviridae Infections / Q000453:epidemiology / Q000821:virology; D014779:Virus Replication / Q000187:drug effects
D000577:Amides; D000998:Antiviral Agents; D002208:Caproates; D003998:Dicarboxylic Acids; D007093:Imidazoles; C539419:pentanedioic acid imidazolyl ethanamide