Cytotoxic ent-kaurane diterpenoids from Isodon sinuolata.
Five (1-5) ent-kaurane diterpenoids and 17 other known ones, were isolated from the leaves and stems of Isodon sinuolata. Their structures were determined on the basis of spectroscopic methods including 1D and 2D NMR spectroscopic analysis. All compounds were evaluated for cytotoxicity against a small panel of cell lines. Some compounds exhibited significant cytotoxicity.
He
Fei
F
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
Xiao
Wei-Lie
WL
Pu
Jian-Xin
JX
Wu
Ying-Li
YL
Zhang
Hai-Bo
HB
Li
Xiao-Nian
XN
Zhao
Yong
Y
Yang
Li-Bin
LB
Chen
Guo-Qiang
GQ
Sun
Han-Dong
HD
D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D045786:Diterpenes, Kaurane / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D037602:Isodon / Q000737:chemistry*; D008297:Male; D009369:Neoplasms / Q000188:drug therapy*; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D018515:Plant Leaves; D018547:Plant Stems
D000972:Antineoplastic Agents, Phytogenic; D045786:Diterpenes, Kaurane; D010936:Plant Extracts