title: Effective monotherapy with amrubicin for a refractory extrapulmonary small-cell carcinoma of the liver.
abstract: Small-cell carcinoma of the liver is a rare neoplasm, and no standard treatment for it has yet been established. A 72-year-old man with an extensive disease stage of small-cell carcinoma of the liver was treated with systemic chemotherapy consisting of cisplatin and etoposide (PE) followed by irinotecan. Although the masses were markedly decreased once after the sixth course of PE, amrubicin monotherapy as third-line chemotherapy was started because the hepatic masses had increased again. The administration of amrubicin was repeated in 8 courses with regression of the disease, resulting in a 26-month survival since the first-line chemotherapy was started. This is the first case report of a refractory EPSCC successfully treated with amrubicin.
authors.affiliation: Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-Ku, Fukuoka 812-8582, Japan.
authors.forename: Taichi
authors.initials: T
authors.lastname: Isobe
authors.forename: Shunichi
authors.initials: S
authors.lastname: Yanai
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Kusaba
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Yada
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Kuroda
authors.forename: Sadafumi
authors.initials: S
authors.lastname: Tamiya
authors.forename: Takayuki
authors.initials: T
authors.lastname: Matsumoto
authors.forename: Eishi
authors.initials: E
authors.lastname: Baba
authors.forename: Mine
authors.initials: M
authors.lastname: Harada