title: Catalytic enantioselective 1,3-dipolar cycloadditions of alkyl diazoacetates with alpha,beta-disubstituted acroleins.
abstract: A catalytic route to highly functionalized chiral 2-pyrazolines by an asymmetric 1,3-dipolar cycloaddition reaction of ethyl diazoacetate with alpha-substituted and alpha,beta-disubstituted acroleins has been developed; in the presence of chiral (S)-oxazaborolidinium ion as catalyst, the reaction proceeded with high to excellent enantioselectivities (up to 99% ee).
authors.affiliation: Department of Chemistry, Sungkyunkwan University, Suwon 440-746, Korea.
authors.forename: Lizhu
authors.initials: L
authors.lastname: Gao
authors.forename: Geum-Sook
authors.initials: GS
authors.lastname: Hwang
authors.forename: Mi Young
authors.initials: MY
authors.lastname: Lee
authors.forename: Do Hyun
authors.initials: DH
authors.lastname: Ryu