title: Improving insulin resistance with traditional Chinese medicine in type 2 diabetic patients.
abstract: Some clinical studies and animal researches have evaluated the efficacy of Traditional Chinese Medicine (TCM) and compared its effects with placebo or other antidiabetic drugs. TCM involves three particular plants, as an antidiabetic drug. Our present research planned to evaluate the efficacy of TCM on insulin sensitivity and other related metabolic factors in type 2 diabetic patients. There were 43 newly diagnosed type 2 diabetic patients enrolled in this study, who did not use any antidiabetic drugs before. They were randomly assigned into TCM and placebo groups, administrated with TCM and placebo, respectively. Glucose disposal rate, fasting plasma glucose, postprandial plasma glucose, glycated hemoglobin, and other metabolic components were assessed at baseline and end point. Glucose disposal rate increased from 5.12 +/- 2.20 to 6.37 +/- 3.51 mg kg(-1) min(-1) in the TCM group, ANCOVA analysis showed that glucose disposal rate in the TCM group was significantly improved as compared to that in the placebo group (P < 0.05). Other metabolic related components such as fasting plasma glucose, postprandial plasma glucose, glycated hemoglobin, systolic blood pressure, diastolic blood pressure, body mass index, retinol binding protein 4 were improved in TCM group, but no statistical differences was detected between the two groups. No severe side effect was found in TCM group. TCM can ameliorate insulin resistance in type 2 diabetes and it is safe and effective in newly diagnosed diabetic patients.
authors.affiliation: Shanghai Clinical Center for Endocrine and Metabolic Diseases and Division of Endocrine and Metabolic Diseases of E-Institutes of Shanghai Universities, Rui-Jin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, 197 RuiJin 2nd Road, Shanghai, 200025, People's Republic of China.
authors.forename: Menglei
authors.initials: M
authors.lastname: Chao
authors.forename: Dajin
authors.initials: D
authors.lastname: Zou
authors.forename: Yifei
authors.initials: Y
authors.lastname: Zhang
authors.forename: Yuhong
authors.initials: Y
authors.lastname: Chen
authors.forename: Miao
authors.initials: M
authors.lastname: Wang
authors.forename: Hong
authors.initials: H
authors.lastname: Wu
authors.forename: Guang
authors.initials: G
authors.lastname: Ning
authors.forename: Weiqing
authors.initials: W
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D027885:Astragalus propinquus / Q000737:chemistry; D039323:Coptis / Q000737:chemistry; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D004311:Double-Blind Method; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007333:Insulin Resistance / Q000502:physiology; D031239:Lonicera / Q000737:chemistry; D008297:Male; D008516:Medicine, Chinese Traditional / Q000379:methods*; D008875:Middle Aged; D010919:Placebos; D055815:Young Adult
chemical_list: D004365:Drugs, Chinese Herbal; D007004:Hypoglycemic Agents; D010919:Placebos