title: Cissus sicyoides: analysis of glycemic control in diabetic rats through biomarkers.
abstract: Diabetes is a chronic degenerative disease with no cure, is found in millions of people worldwide, and can cause life-threatening complications at any age. The plant Cissus sicyoides L. is a runner plant found abundantly in Brazil, especially in the Amazon. Its therapeutic properties are widely used in popular medicine as a diuretic, anti-influenza, anti-inflammatory, anticonvulsion, and hypoglycemic agent. The objective of this study was to analyze the effects of aqueous extracts from the leaves and stem of C. sicyoides L., administered for 60 days, for the control of glycemia in alloxan (monohydrate)-induced diabetic rats, monitored by biomarkers. Data obtained in this study confirmed that C. sicyoides has a hypoglycemic effect on diabetic rats. Administration of its aqueous extracts promoted a 45% decrease in glucose levels after 60 days of administration. Furthermore, indices of hepatic glycogen, blood glucose, C-reactive peptide, and fructosamine were found to be efficient biomarkers to monitor diabetes in rats.
authors.affiliation: Department of Agroindustry, Foods and Nutrition, University of São Paulo/Escola Superior de Agricultura Luiz de Queiroz, Piracicaba, São Paulo, Brazil. jmsalgad@esalq.usp.br
authors.forename: Jocelem Mastrodi
authors.initials: JM
authors.lastname: Salgado
authors.forename: Débora Niero
authors.initials: DN
authors.lastname: Mansi
authors.forename: Antonio
authors.initials: A
authors.lastname: Gagliardi
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism*; D001938:Brazil; D002097:C-Reactive Protein / Q000378:metabolism; D032422:Cissus; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000378:metabolism; D019270:Fructosamine / Q000097:blood; D006003:Glycogen / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D018515:Plant Leaves; D018547:Plant Stems; D051381:Rats; D017208:Rats, Wistar
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D019270:Fructosamine; D006003:Glycogen; D002097:C-Reactive Protein