Adiponectin gene +45T/G and +276G/T polymorphism and antipsychotic-induced weight gain.
OBJECTIVE
To investigate whether antipsychotic-induced weight gain was associated with adiponectin gene +45T/G and +276G/T polymorphism.


METHODS
A case-matched study was done: 85 patients who gained more than 7% of their pre-drug body weight were designed to the study group and 85 patients who gained less than 7% of their pre-drug body weight served as the control group. Ligation diction reaction technique was used to analyze the frequencies of the +276G/T and +45T/G polymorphism of adiponectin gene.


RESULTS
The presence of +276G allele was significantly higher in the study group as compared with the control group.


CONCLUSIONS
Subjects with the +276G variant alleles may have a greater risk for weight gain after antipsychotic treatment.
Li
Lehua
L
Mental Health Instittute, Second Xiangya Hospital, Central South University, Changsha 410011, China.
Wu
Renrong
R
Zhao
Jingping
J
D052242:Adiponectin / Q000235:genetics*; D000293:Adolescent; D000328:Adult; D000483:Alleles; D014150:Antipsychotic Agents / Q000009:adverse effects*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012559:Schizophrenia / Q000188:drug therapy / Q000235:genetics; D015430:Weight Gain / Q000187:drug effects / Q000235:genetics*; D055815:Young Adult
D052242:Adiponectin; D014150:Antipsychotic Agents