title: The impact of malaria parasitism: from corpuscles to communities.
abstract: Malaria continues to exert a tremendous health burden on human populations, reflecting astonishingly successful adaptations of the causative Plasmodium parasites. We discuss here how this burden has driven the natural selection of numerous polymorphisms in the genes encoding hemoglobin and other erythrocyte proteins and some effectors of immunity. Plasmodium falciparum, the most deadly parasite species in humans, displays a vigorous system of antigen variation to counter host defenses and families of functionally redundant ligands to invade human cells. Advances in genetics and genomics are providing fresh insights into the nature of these evolutionary adaptations, processes of parasite transmission and infection, and the difficult challenges of malaria control.
authors.affiliation: Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892-8132, USA. twellems@niaid.nih.gov
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Wellems
authors.forename: Karen
authors.initials: K
authors.lastname: Hayton
authors.forename: Rick M
authors.initials: RM
authors.lastname: Fairhurst
mesh_terms: D000818:Animals; D000852:Anopheles / Q000469:parasitology; D000940:Antigenic Variation / Q000235:genetics; D000962:Antimalarials / Q000266:history / Q000627:therapeutic use; D005075:Biological Evolution; D004912:Erythrocytes / Q000469:parasitology; D005260:Female; D015894:Genome, Human; D049673:History, 20th Century; D049674:History, 21st Century; D006790:Host-Parasite Interactions / Q000235:genetics / Q000276:immunology / Q000502:physiology; D006801:Humans; D007303:Insect Vectors / Q000469:parasitology; D008288:Malaria / Q000235:genetics / Q000266:history / Q000276:immunology / Q000469:parasitology*; D008297:Male; D010963:Plasmodium falciparum / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity; D011110:Polymorphism, Genetic; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000235:genetics / Q000469:parasitology; D055544:beta-Globins / Q000235:genetics
chemical_list: D000962:Antimalarials; D055544:beta-Globins