[Correlation of multi-slice spiral CT features to clinicopathologic manifestations of gastrointestinal stromal tumor: a report of 49 cases].
OBJECTIVE
Gastrointestinal stromal tumor (GIST) is one of the most common mesenchymal tumors of the digestive system. Imaging examination plays an important role in preoperative diagnosis and postoperative evaluation for it. This study was to describe the multi-slice spiral computed tomographic (MSCT) findings and pathologic features of GIST, and to analyze their correlation.


METHODS
MSCT and pathologic reports of 49 patients with 53 pathologically confirmed GIST lesions were reviewed and compared.


RESULTS
Of the 53 GIST lesions, 14 were at very low biological risk, 11 at low risk, ten at moderate risk and 18 at high risk; 36 (67.9%) were found in first visit by CT scans. On CT images, the GIST lesions with maximal diameter of > or =50 mm showed irregular shape, invasive growth, presence of cystic area and heterogeneous enhancement, and most of them were at high risk; the lesions with maximal diameter of <50 mm showed regular shape, expansive growth, and homogeneous enhancement, and most of them were at risk of moderate or below. No lymph node metastasis was found. Only three lesions showed S100-positive, which presented infiltration along the gastric wall or bowel ring on CT images.


CONCLUSIONS
CT examination is helpful in risk prediction for GIST, but it is difficult to detect small lesions (< 2 cm) by CT scans. Due to the infiltrative growth of GIST with neural differentiation (S100-positive), it is difficult to distinguish GIST from gastric cancer on CT images.
Yin
Shao-Han
SH
State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, 510060, PR China.
Xie
Chuan-Miao
CM
Mo
Yun-Xian
YX
Huang
Zi-Lin
ZL
Lu
Yan-Chun
YC
Liu
Xue-Wen
XW
Zhang
Yun
Y
Li
Jian-Peng
JP
Zheng
Lie
L
Wu
Pei-Hong
PH
D000293:Adolescent; D000328:Adult; D000368:Aged; D003937:Diagnosis, Differential; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000175:diagnosis; D046152:Gastrointestinal Stromal Tumors / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007889:Leiomyoma / Q000175:diagnosis; D007890:Leiomyosarcoma / Q000175:diagnosis; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary; D008297:Male; D008875:Middle Aged; D009442:Neurilemmoma / Q000175:diagnosis; D009418:S100 Proteins / Q000378:metabolism; D036542:Tomography, Spiral Computed / Q000379:methods*; D047368:Tumor Burden; D055815:Young Adult
D009418:S100 Proteins