title: Abnormal fronto-striatal connectivity in children with histories of early deprivation: A diffusion tensor imaging study.
abstract: An Inattentive/Overactive (I/O) behavioral phenotype has been reported in a significant percentage of children raised from birth in orphanages. While a number of studies have identified both functional and structural brain abnormalities in children raised from birth in orphanages, no published studies have evaluated potential neural correlates of the I/O phenotype. We applied diffusion tensor imaging (DTI) to 15 pre-teen children raised in orphanages in Eastern Europe or Asia and later adopted to the US. Fiber tracts were constructed from DTI data using probabilistic fiber tracking and the cortical fiber distribution of fibers originating from the head of the caudate was compared between the early deprivation (ED) group and 12 age-matched controls. The ED group showed a more diffuse connectivity pattern, especially in the right hemisphere, potentially related to incomplete neuronal pruning during development. These structural abnormalities may be associated with inattention and overactivity encountered in children with ED.
authors.affiliation: Department of Pediatrics, Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit, MI, USA.
authors.forename: Michael E
authors.initials: ME
authors.lastname: Behen
authors.forename: Otto
authors.initials: O
authors.lastname: Muzik
authors.forename: Anita S D
authors.initials: AS
authors.lastname: Saporta
authors.forename: Benjamin J
authors.initials: BJ
authors.lastname: Wilson
authors.forename: Darshan
authors.initials: D
authors.lastname: Pai
authors.forename: Jing
authors.initials: J
authors.lastname: Hua
authors.forename: Harry T
authors.initials: HT
authors.lastname: Chugani