title: Decatenation: fixing your knots.
abstract: How tumor cells gain resistance to drugs is critically important to elucidate for developing better cancer therapy. In this issue of Blood, Wray and colleagues have identified a mechanism whereby acute leukemia cells use a stimulator of topoisomerase II activity to allow proliferation despite drug inhibition of this essential enzyme.
authors.affiliation: University of Minnesota.
authors.forename: Duncan J
authors.initials: DJ
authors.lastname: Clarke