title: Helicobacters and extragastric diseases.
abstract: For two decades, Helicobacter pylori has been considered as the culprit in many extragastric manifestations. However, for several of these supposed associations the hypothesis of an etiological role has not yet been fully investigated. This may be due to a series of factors linked to the epidemiological features of the studies and to the diseases investigated. This review attempts to highlight the main reported associations of H. pylori with extragastric manifestations during the last year. The most convincing data arise in the field of idiopathic thrombocytopenic purpura (ITP) and sideropenic anemia. Long-term follow-up studies have shown that 50% of subjects with ITP maintain a hematological response after H. pylori eradication. There is also growing evidence of the role of H. pylori in other diseases, including ischemic heart disease even though results are not conclusive.
authors.affiliation: Department of Gastro-Hepatology, Molinette Hospital, Turin, Italy.
authors.forename: Rinaldo
authors.initials: R
authors.lastname: Pellicano
authors.forename: Francesco
authors.initials: F
authors.lastname: Franceschi
authors.forename: Giorgio
authors.initials: G
authors.lastname: Saracco
authors.forename: Sharmila
authors.initials: S
authors.lastname: Fagoonee
authors.forename: Davide
authors.initials: D
authors.lastname: Roccarina
authors.forename: Antonio
authors.initials: A
authors.lastname: Gasbarrini
mesh_terms: D000740:Anemia / Q000382:microbiology; D000818:Animals; D004194:Disease / Q000209:etiology*; D016481:Helicobacter Infections / Q000209:etiology / Q000382:microbiology*; D016480:Helicobacter pylori / Q000502:physiology*; D006801:Humans; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000209:etiology / Q000382:microbiology; D013272:Stomach Diseases / Q000209:etiology / Q000382:microbiology