title: Factors correlated to successful surgical treatment of 181 non-palpable invasive breast carcinomas.
abstract: Surgical treatment of non-palpable solitary invasive carcinoma consists of localization, tumorectomy and sentinel lymph node biopsy which can successfully be performed with the use of isotopes (SNOLL). The aim of our study was to find out the success rate of SNOLL and the factors that correlated with complete excision of invasive carcinoma. Solitary non-palpable carcinoma was preoperatively diagnosed in 181 cases. After peritumoral injection of nanocolloid labeled with 99mTc under mammographic (N=79) or ultrasound (N=102) guidance, tumorectomy and sentinel node biopsy were performed. Clear surgical margins were obtained in 82% of cases. Surgical margins were likely to be clear (p<0.05) if: (1) the patients were older than 50 years, (2) the weight of surgical specimens >50 g, (3) the tumor radiologic diameter was <or=20 mm, (4) invasive carcinoma was ductal rather than other types of invasive carcinomas. Only one surgical procedure was sufficient for surgical treatment of 75% of cases with non-palpable solitary invasive carcinoma.
authors.affiliation: Department of Surgical Oncology, Institute of Oncology, Ljubljana, Slovenia. nbesic@onko-i.si
authors.forename: Nikola
authors.initials: N
authors.lastname: Besic
authors.forename: Anja
authors.initials: A
authors.lastname: Kramaric
authors.forename: Blaze
authors.initials: B
authors.lastname: Podnar
authors.forename: Andraz
authors.initials: A
authors.lastname: Perhavec
authors.forename: Maja
authors.initials: M
authors.lastname: Music
authors.forename: Snjezana
authors.initials: S
authors.lastname: Grazio-Frkovic
authors.forename: Janez
authors.initials: J
authors.lastname: Zgajnar
mesh_terms: D000328:Adult; D000368:Aged; D044963:Biopsy, Fine-Needle; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D018270:Carcinoma, Ductal, Breast / Q000000981:diagnostic imaging / Q000532:radiotherapy / Q000601:surgery*; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000000981:diagnostic imaging; D008875:Middle Aged; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D021701:Sentinel Lymph Node Biopsy; D013668:Technetium Tc 99m Aggregated Albumin; D016896:Treatment Outcome
chemical_list: D019275:Radiopharmaceuticals; D013668:Technetium Tc 99m Aggregated Albumin; C083602:technetium Tc 99m nanocolloid