title: Circulating endothelial progenitor cells predict angiographic and intravascular ultrasound outcome following percutaneous coronary interventions in the HEALING-II trial: evaluation of an endothelial progenitor cell capturing stent.
abstract: OBJECTIVE
  In contrast to the cytostatic and cytotoxic pharmacotherapy of drug eluting stents, approaches to stimulate the arterial healing response by accelerating re-endothelialisation may be an attractive alternative to prevent post-stenting neointimal formation and thrombosis. The study sought to evaluate whether stainless steel stents able to sequester endothelial progenitor cells (EPCs) to the stent surface to promote the endogenous arterial healing, can prevent in-stent restenosis and stent thrombosis.
  
  
  RESULTS
  The HEALING-II study was a multicentre, prospective registry study, including 63 patients treated with the implantation of a Genous EPC capture stent. The primary safety endpoint was Major Adverse Cardiac Events (MACE) at 30 days, whereas the primary efficacy endpoint was percent in-stent volume obstruction at 6 months by intravascular ultrasound (IVUS). The 9 month composite MACE rate was 7.9%, whereas 6.3% clinically justified target lesion revascularisations were observed. Although patients received one month of clopidogrel, no angiographic stent thrombosis occurred. In-stent late luminal loss was 0.78+/-0.39 mm and percent in-stent volume obstruction was 22.9+/-13.7% (mean+/-sd). Patients with normal EPC titers at 6 months FU responded favourably to the EPC capturing stent (late luminal loss 0.53+/-0.06) as opposed to patients with low EPC titers (late luminal loss 1.01+/-0.07). These low circulating EPC titers were generally associated with the lack of HMG-Co-A reductase inhibitors ('statins') at the time of stent implantation and diabetes mellitus.
  
  
  CONCLUSIONS
  The HEALING-II study suggests that the EPC capture coronary stents are safe and effective for the treatment of de novo coronary artery disease in patients with normal EPC levels.
authors.affiliation: Thoraxcenter, Erasmus University Medical Center Rotterdam, The Netherlands.
authors.forename: Henricus J
authors.initials: HJ
authors.lastname: Duckers
authors.forename: Sigmund
authors.initials: S
authors.lastname: Silber
authors.forename: Robbert
authors.initials: R
authors.lastname: de Winter
authors.forename: Peter
authors.initials: P
authors.lastname: den Heijer
authors.forename: Benno
authors.initials: B
authors.lastname: Rensing
authors.forename: Matthias
authors.initials: M
authors.lastname: Rau
authors.forename: Harald
authors.initials: H
authors.lastname: Mudra
authors.forename: Edouard
authors.initials: E
authors.lastname: Benit
authors.forename: Stefan
authors.initials: S
authors.lastname: Verheye
authors.forename: William
authors.initials: W
authors.lastname: Wijns
authors.forename: Patrick W
authors.initials: PW
authors.lastname: Serruys