Sister Mary Joseph's nodule: a case of umbilical cutaneous metastasis with signet ring cell histology.
The metastasis of a visceral malignancy to the umbilicus is known as "Sister Mary Joseph's nodule". It is a rare clinical sign indicating advanced, metastasizing intraabdominal cancer. We report a 50-year-old man who developed metastatic skin cancer in the form of semicircular indurated plaque on top of which was a firm mobile rounded nodule at the umbilical area. Histopathological examination demonstrated diastase-resistant periodic acid-Schiff and mucicarmine positive signet ring cells, suggesting gastric carcinoma. Immunohistochemical staining showed that these cells were positive for cytokeratins and epithelial membrane antigen, suggesting epithelial origin.
Zadeh
Valid Bagher
VB
Department of Dermatology, Adan Hospital, Kuwait. walid_md2000@hotmail.com
Kadyan
Randhir
R
Al-Abdulrazzaq
Adel
A
Al-Otaibi
Sultan
S
Sarhan
Amr
A
Najem
Nabeel
N
D006801:Humans; D008297:Male; D008875:Middle Aged; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000556:secondary*; D014472:Umbilicus / Q000473:pathology*