title: Pharmacokinetic interaction of some antitubercular drugs with caraway: implications in the enhancement of drug bioavailability.
abstract: This study deals with the pharmacokinetic interaction of selected anti-TB drugs with a natural product (CC-1a) derived from caraway (Carum carvi, L.) seed. CC-1a, chemically standardized butanolic fraction, enhanced the plasma levels of rifampicin, pyrazinamide, and isoniazid in Wistar rat, resulting in increased bioavailability indices (C(max) and AUC) of the drugs. Moreover, a 40% reduced dose regimen of these drugs, which additionally contained CC-1a, was equivalent in terms of C(max) and AUC to a normal dose regimen. A permeation-enhancing property of CC-1a across small intestinal absorptive surface was found to be a contributing factor in its bioavailability enhancing profile.
authors.affiliation: Division of Pharmacology, Indian Institute of Integrative Medicine (CSIR), (Formerly Regional Research Laboratory), Jammu-Tawi, India.
authors.forename: B S
authors.initials: BS
authors.lastname: Sachin
authors.forename: P
authors.initials: P
authors.lastname: Monica
authors.forename: S C
authors.initials: SC
authors.lastname: Sharma
authors.forename: N K
authors.initials: NK
authors.lastname: Satti
authors.forename: M K
authors.initials: MK
authors.lastname: Tikoo
authors.forename: A K
authors.initials: AK
authors.lastname: Tikoo
authors.forename: K A
authors.initials: KA
authors.lastname: Suri
authors.forename: B D
authors.initials: BD
authors.lastname: Gupta
authors.forename: R K
authors.initials: RK
authors.lastname: Johri
mesh_terms: D000818:Animals; D000995:Antitubercular Agents / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001682:Biological Availability; D029974:Carum / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D004347:Drug Interactions; D005260:Female; D007408:Intestinal Absorption / Q000187:drug effects; D007413:Intestinal Mucosa / Q000187:drug effects / Q000378:metabolism; D007538:Isoniazid / Q000493:pharmacokinetics; D007583:Jejunum / Q000378:metabolism; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology; D011718:Pyrazinamide / Q000493:pharmacokinetics; D051381:Rats; D017208:Rats, Wistar; D012015:Reference Standards; D012293:Rifampin / Q000493:pharmacokinetics; D012639:Seeds / Q000737:chemistry; D012997:Solvents
chemical_list: D000995:Antitubercular Agents; D010936:Plant Extracts; D012997:Solvents; D011718:Pyrazinamide; D007538:Isoniazid; D012293:Rifampin