title: Evaluation of the genetic variants of kinesin motor protein in ischemic stroke.
abstract: BACKGROUND
  The kinesin light-chain 1 genetic variants G56836C, A185C, and C406T were earlier found to amplify the development of leukoaraiosis in hypertensive smokers. These 3 variants were presumed to affect the function of the mitochondria, thereby giving rise to sensitivity to a chronic ischemic state. We have now extended our investigations to examine how the above genetic variants affect the occurrence of ischemic stroke.
  
  
  METHODS
  Genetic and clinical data on 650 ischemic stroke and 340 neuroimaging alteration-free subjects were analyzed. Univariate and logistic regression approaches were used.
  
  
  RESULTS
  None of the above genetic variants proved to be risk factors of ischemic stroke, either alone or in combination with other clinical factors.
  
  
  CONCLUSIONS
  The examined 3 genetic variants seem to influence the responses of the glial cells to a slight chronic hypoxia state, rather than the mechanisms resulting in cerebral infarcts themselves.
authors.affiliation: Department of Cerebrovascular Diseases, Pándy Kálmán County Hospital, Gyula, Hungary. szolnoki99@hotmail.com
authors.forename: Zoltan
authors.initials: Z
authors.lastname: Szolnoki
authors.forename: Julianna
authors.initials: J
authors.lastname: Serly
authors.forename: Andras
authors.initials: A
authors.lastname: Kondacs
authors.forename: Yvette
authors.initials: Y
authors.lastname: Mandi
authors.forename: Ferenc
authors.initials: F
authors.lastname: Somogyvari
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000378:metabolism / Q000503:physiopathology; D004252:DNA Mutational Analysis; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005820:Genetic Testing; D014644:Genetic Variation / Q000235:genetics*; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000453:epidemiology / Q000235:genetics* / Q000503:physiopathology; D016547:Kinesins / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009457:Neuroglia / Q000378:metabolism; D010101:Oxygen Consumption / Q000502:physiology; D011110:Polymorphism, Genetic / Q000235:genetics; D012307:Risk Factors; D020521:Stroke / Q000453:epidemiology / Q000235:genetics* / Q000503:physiopathology
chemical_list: D005819:Genetic Markers; D016547:Kinesins