title: Bioactive triterpenes from Diospyros blancoi.
abstract: The ethyl acetate extract of the air-dried leaves of Diospyros blancoi afforded isoarborinol methyl ether (1), a mixture of alpha-amyrin palmitate, alpha-amyrin palmitoleate, beta-amyrin palmitate and beta-amyrin palmitoleate (2) in a 13 : 4 : 3 : 1 ratio, and squalene. The structures of 1, 2 and squalene were elucidated by extensive 1D and 2D NMR spectroscopy. Compounds 1 and 2 exhibited antimicrobial activity against Escherichia coli, Pseudomonas aeruginosa, Candida albicans, Staphylococcus aureus and Trichophyton mentagrophytes, and were found inactive against Bacillus subtilis and Aspergillus niger. Sample 2 exhibited significant analgaesic and anti-inflammatory activities.
authors.affiliation: Chemistry Department, Center for Natural Sciences and Ecological Research, De La Salle University, 1004 Manila, Philippines. ragasac@dlsu.edu.ph
authors.forename: Consolacion Y
authors.initials: CY
authors.lastname: Ragasa
authors.forename: Marc Rhyan Anthony
authors.initials: MR
authors.lastname: Puno
authors.forename: Josephine Marie Angeline P
authors.initials: JM
authors.lastname: Sengson
authors.forename: Chien-Chang
authors.initials: CC
authors.lastname: Shen
authors.forename: John A
authors.initials: JA
authors.lastname: Rideout
authors.forename: Dennis D
authors.initials: DD
authors.lastname: Raga
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology*; D001234:Aspergillus niger / Q000187:drug effects; D001412:Bacillus subtilis / Q000187:drug effects; D001419:Bacteria / Q000187:drug effects*; D002176:Candida albicans / Q000187:drug effects; D029788:Diospyros / Q000737:chemistry*; D004926:Escherichia coli / Q000187:drug effects; D005658:Fungi / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013211:Staphylococcus aureus / Q000187:drug effects; D014249:Trichophyton / Q000187:drug effects; D014315:Triterpenes / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D014315:Triterpenes