title: Effect of captopril on pulmonary artery pressure following corrective surgery for tetralogy of fallot.
abstract: BACKGROUND
  This study was designed to investigate the effect of captopril on systolic pulmonary arterial pressure (PAP) and circulating endothelin-1 (ET-1) following surgical repair of tetralogy of Fallot (TOF).
  
  
  RESULTS
  Seventy-six consecutive patients were divided into captopril and control groups following successful repair of TOF. The captopril group was treated with oral captopril (0.2 mg/kg/day) for 12 months. Venous blood was taken before and after the surgery for the analysis of ET-1. Systolic PAP and ventricular function were assessed by Doppler echocardiography. In the control group, there was an increase in ET-1 and systolic PAP following the surgery (p < 0.05). In the captopril group, there was no significant increase in the systolic PAP and ET-1 during the 12-month follow-up. The PAP and ET-1 values in the captopril group were lower than those in the control group following the surgery (p < 0.05).
  
  
  CONCLUSIONS
  Systolic PAP is elevated following the complete surgical repair of TOF. Increased circulating ET-1 may be responsible for the elevation of PAP. Captopril treatment prevents postsurgical increases in systolic PAP and circulating ET-1.
authors.affiliation: Department of Cardiac Surgery, Liaocheng People's Hospital and Liaocheng Clinical School of Taishan Medical University, Liaocheng, Shandong 252000, People's Republic of China.
authors.forename: Zeng-Shan
authors.initials: ZS
authors.lastname: Ma
authors.forename: Sheng-Jun
authors.initials: SJ
authors.lastname: Ma
authors.forename: Ming-Feng
authors.initials: MF
authors.lastname: Dong
authors.forename: Jian-Tang
authors.initials: JT
authors.lastname: Wang
authors.forename: Le-Xin
authors.initials: LX
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects*; D002216:Captopril / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D019332:Endothelin-1 / Q000097:blood / Q000187:drug effects*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D011184:Postoperative Period; D011651:Pulmonary Artery / Q000000981:diagnostic imaging / Q000187:drug effects*; D013599:Systole; D013771:Tetralogy of Fallot / Q000601:surgery*; D013997:Time Factors; D018615:Ultrasonography, Doppler, Color; D055815:Young Adult
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D019332:Endothelin-1; D002216:Captopril