title: HELLP syndrome, multiple liver infarctions, and intrauterine fetal death in a patient with systemic lupus erythematosus and antiphospholipid syndrome.
abstract: We report a case of HELLP syndrome, multiple liver infarctions, and intrauterine fetal death in a woman in the 17th week of pregnancy with SLE and APS who had been in remission on a regimen of low-dose prednisolone and aspirin. An increase in the dosage of corticosteroid together with intravenous heparin infusion led to improvement of the clinical symptoms, laboratory parameters, and multifocal low-density liver lesions detected by computed tomography. Early onset and signs of severe organ involvement are the characteristic features of HELLP syndrome associated with APS, and patients that are at risk should be followed up carefully.
authors.affiliation: Clinical Nephrology and Rheumatology, Department of Medicine II, Niigata University Graduate School of Medical and Dental Sciences, Niigata. yoko.wada@gmail.com
authors.forename: Yoko
authors.initials: Y
authors.lastname: Wada
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Sakamaki
authors.forename: Daisuke
authors.initials: D
authors.lastname: Kobayashi
authors.forename: Junya
authors.initials: J
authors.lastname: Ajiro
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Moro
authors.forename: Shuichi
authors.initials: S
authors.lastname: Murakami
authors.forename: Izumi
authors.initials: I
authors.lastname: Ooki
authors.forename: Akira
authors.initials: A
authors.lastname: Kikuchi
authors.forename: Koichi
authors.initials: K
authors.lastname: Takakuwa
authors.forename: Kenichi
authors.initials: K
authors.lastname: Tanaka
authors.forename: Takehiro
authors.initials: T
authors.lastname: Sato
authors.forename: Masaaki
authors.initials: M
authors.lastname: Nakano
authors.forename: Ichiei
authors.initials: I
authors.lastname: Narita
mesh_terms: D000328:Adult; D016736:Antiphospholipid Syndrome / Q000150:complications / Q000175:diagnosis*; D005260:Female; D005313:Fetal Death / Q000175:diagnosis*; D017359:HELLP Syndrome / Q000175:diagnosis*; D006801:Humans; D008107:Liver Diseases / Q000150:complications / Q000175:diagnosis*; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000175:diagnosis*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis*