Parallel liquid-phase synthesis of 5-(1H-4-pyrazolyl)-[1,2,4]oxadiazole libraries.
Combinatorial libraries of substituted 3-(methylthio)-5-(amino)-4-([1,2,4]oxadiazol-5-yl)-1H-pyrazoles 6, 10, 13, 15 (395 members, yields 32-87%), 4-([1,2,4]oxadiazol-5-yl)-1H-3,5-pyrazolediamines 8, 11 (571 members, yields 25-83%), 2-(methylthio)-3-([1,2,4]oxadiazol-5-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-ones 17 (85 members, yields 56-95%), and 2-(amino)-3-([1,2,4]oxadiazol-5-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-ones 18 (110 members, yields 56-95%) were synthesized by the parallel liquid-phase synthesis method.
Borisov
Alexander V
AV
National University of Pharmacy, Pushkinska str.53, 61002 Kharkiv, Ukraine. borisov@onet.com.ua
Detistov
Oleksandr S
OS
Pukhovaya
Viktoria I
VI
Zhuravel'
Irina O
IO
Kovalenko
Sergiy M
SM
D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D015394:Molecular Structure; D010069:Oxadiazoles / Q000138:chemical synthesis* / Q000737:chemistry; D011720:Pyrazoles / Q000737:chemistry; D054852:Small Molecule Libraries; D013237:Stereoisomerism
D010069:Oxadiazoles; D011720:Pyrazoles; D054852:Small Molecule Libraries