title: HLA B27 as predisposition factor to suffer age related macular degeneration.
abstract: To research whether specific alleles HLA class I (HLA-A and HLA-B) and class II (HLA-DR) are risk factors for the development of exudative type of Age Related Macular Degeneration (ARMD), HLA antigens are expressed both in normal and affected eyes with ARMD. We designed a prospective case-controlled study. We recruited 75 patients with choroidal neovascularization predominantly classic or occult, secondary to ARMD, and treated with photodynamic therapy. Two hundred and fifty patients over 55 years old, without ophthalmologic pathology who went to hospital for an analytical routine check were used as control. The analysis of the data shows a significant difference between two groups. Allele HLA-B27 correlated positively with ARMD (p < 0.0113). However, we didn't find alleles negatively associated. Thus HLA-B27 is an allele predisposed to suffer ARMD.
authors.affiliation: Hospital Universitario Reina Sofia, CP 14011, Córdoba, Spain. drvill@terra.es
authors.forename: Enrique
authors.initials: E
authors.lastname: Villegas Becerril
authors.forename: Rafael
authors.initials: R
authors.lastname: González Fernández
authors.forename: Luis
authors.initials: L
authors.lastname: Pérula Torres
authors.forename: Manuel Santos
authors.initials: MS
authors.lastname: Lacomba
authors.forename: José María
authors.initials: JM
authors.lastname: Gallardo Galera
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D020256:Choroidal Neovascularization / Q000209:etiology / Q000235:genetics* / Q000503:physiopathology / Q000628:therapy; D005122:Exudates and Transudates / Q000378:metabolism*; D005260:Female; D020022:Genetic Predisposition to Disease; D015234:HLA-A Antigens / Q000235:genetics; D015796:HLA-B27 Antigen / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics; D006650:Histocompatibility Testing; D006801:Humans; D008268:Macular Degeneration / Q000150:complications / Q000235:genetics* / Q000503:physiopathology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010778:Photochemotherapy; D011110:Polymorphism, Genetic; D011446:Prospective Studies; D012307:Risk Factors
chemical_list: D015234:HLA-A Antigens; D015796:HLA-B27 Antigen; D006684:HLA-DR Antigens