Small-colony variant selection as a survival strategy for Staphylococcus aureus in the presence of Pseudomonas aeruginosa.
Previously it has been demonstrated that Staphylococcus aureus is sensitive toward Pseudomonas-secreted exotoxins, which preferentially target the electron transport chain in staphylococci. Here it is shown that a subpopulation of S. aureus survives these respiratory toxins of Pseudomonas aeruginosa by selection of the small-colony variant (SCV) phenotype. Purified pyocyanin alone causes the same effect. A hemB mutant of S. aureus survives cocultivation with P. aeruginosa without a decrease in CFU.
Biswas
Lalitha
L
Institute of Microbial Genetics, University of Tübingen, 72076 Tübingen, Germany.
Biswas
Raja
R
Schlag
Martin
M
Bertram
Ralph
R
Götz
Friedrich
F
D000898:Antibiosis; D050296:Microbial Viability; D011550:Pseudomonas aeruginosa / Q000254:growth & development / Q000502:physiology*; D011710:Pyocyanine / Q000633:toxicity; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development / Q000502:physiology*; D013312:Stress, Physiological
D011710:Pyocyanine