title: Melanoma promotion after photodynamic therapy of a suspected Bowen's disease lesion.
abstract: We report on a 61-year-old male patient who developed a melanoma at the site of a suspected Bowen's lesion on the right cheek. This lesion had evolved for years and had been treated using photodynamic therapy (PDT) in an outpatient facility. Only a couple of months after a single PDT treatment, a melanoma was histologically diagnosed. After excision, multiple metastases were found. The therapeutic strategy comprised re-excision, neck dissection and lateral parotidectomy - due to a metastasis - as well as subsequent alpha-interferon injections. The possible role of PDT in the promotion of melanoma is discussed.
authors.affiliation: Department of Dermatology, University Hospital Regensburg, Regensburg, Germany.
authors.forename: Stephan
authors.initials: S
authors.lastname: Schreml
authors.forename: Susanne
authors.initials: S
authors.lastname: Gantner
authors.forename: Julia
authors.initials: J
authors.lastname: Steinbauer
authors.forename: Philipp
authors.initials: P
authors.lastname: Babilas
authors.forename: Michael
authors.initials: M
authors.lastname: Landthaler
authors.forename: Rolf-Markus
authors.initials: RM
authors.lastname: Szeimies
mesh_terms: D001706:Biopsy; D001913:Bowen's Disease / Q000175:diagnosis / Q000188:drug therapy*; D002610:Cheek; D003937:Diagnosis, Differential; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008545:Melanoma / Q000175:diagnosis / Q000209:etiology*; D008875:Middle Aged; D010778:Photochemotherapy / Q000009:adverse effects*; D017319:Photosensitizing Agents / Q000009:adverse effects* / Q000627:therapeutic use; D012878:Skin Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D014057:Tomography, X-Ray Computed
chemical_list: D017319:Photosensitizing Agents