Pyrodysinoic acid derivatives from the marine sponge Dysidea robusta.
Three new nitrogen-containing terpenes related to pyrodysinoic acid (1) have been isolated from the sponge Dysidea robusta collected in Brazil. Isopyrodysinoic acid (2), 13-hydroxyisopyrodysinoic acid (3), and pyrodysinoic acid B (4) were obtained from the crude extract of D. robusta and identified by analysis of spectroscopic data. Pyrodysinoic acid B (4) is the first furodysin or furodysinin sesquiterpene derivative with a trans junction between the two six-membered rings of the 1,2,3,4,4a,7,8,8a-octahydro-1,1,6-trimethylnaphthalene moiety.
Williams
David E
DE
Instituto de Química de São Carlos, Universidade de São Paulo, São Carlos, SP, Brazil.
Marques
Suzi O
SO
Hajdu
Eduardo
E
Peixinho
Solange
S
Andersen
Raymond J
RJ
Berlinck
Roberto G S
RG
D000818:Animals; D001938:Brazil; D047088:Dysidea / Q000737:chemistry*; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification*
D012717:Sesquiterpenes; C442627:pyrodysinoic acid