title: Foreign body granulomas after injection of Bio-alcamid for lip augmentation.
abstract: Bio-alcamid is one of the newest agents on the market for soft tissue augmentation. Seven studies were documented in the medical literature that examined the safety of Bio-alcamid (Polymekon, Brindisy, Italy); all reported no cases of tissue migration, foreign body granulomas, allergenicity, or interference with the control of cell proliferation. On 2 separate occasions, a woman who had recently undergone lip augmentation presented at our hospital with submucosal nodules of the lip. Histologic examination revealed multiple foreign body-type granulomas composed of giant cells, epithelioid cells, and chronic inflammation of the lip. Efforts to produce a cosmetic material that fulfills all the criteria as an "ideal" agent has not yet been found because all injectable foreign agents have the potential to induce adverse reactions. Caution must be exercised in all cases and the risks explained to the patient before its use.
authors.affiliation: Department Oral Pathology and Medicine, School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Sharon
authors.initials: S
authors.lastname: Akrish
authors.forename: Dan
authors.initials: D
authors.lastname: Dayan
authors.forename: Shlomo
authors.initials: S
authors.lastname: Taicher
authors.forename: Iris
authors.initials: I
authors.lastname: Adam
authors.forename: Rafael M
authors.initials: RM
authors.lastname: Nagler
mesh_terms: D000180:Acrylic Resins; D000328:Adult; D001672:Biocompatible Materials / Q000009:adverse effects*; D003357:Cosmetic Techniques / Q000009:adverse effects*; D005260:Female; D015745:Granuloma, Foreign-Body / Q000139:chemically induced* / Q000209:etiology / Q000601:surgery; D006801:Humans; D007279:Injections, Subcutaneous / Q000009:adverse effects; D008046:Lip / Q000601:surgery*; D011183:Postoperative Complications / Q000139:chemically induced / Q000209:etiology / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D000180:Acrylic Resins; C470344:Bio-Alcamid; D001672:Biocompatible Materials