title: Outcome of multiple-wire localization for larger breast cancers: do multiple wires translate into additional imaging, biopsies, and recurrences?
abstract: BACKGROUND
  Breast conservation is possible in breast cancer patients whose mammographic lesions are large enough to require multiple localizing wires for excision.
  
  
  METHODS
  A retrospective review of 112 patients who underwent multiple-wire and 160 controls who underwent single-wire lumpectomy for breast cancer. Rates of in-breast recurrence, metastasis, and additional imaging and biopsy procedures were calculated.
  
  
  RESULTS
  The median follow-up was 24 months. One multiple-wire and 2 single-wire patients developed in-breast recurrences (P = .84). No distant metastases developed among the multiple-wire patients. Additional follow-up imaging was obtained in 29% of multiple-wire and 22% of single-wire cases (P = .1). Seven (6%) of the multiple-wire and 11 (6%) of the single-wire cases underwent biopsy (P = .94).
  
  
  CONCLUSIONS
  We found no increased risk of early local recurrence, metastasis, or additional imaging or biopsies in patients requiring multiple-wire localization for lumpectomy. Breast conservation should be considered a safe option even for patients with mammographically extensive lesions.
authors.affiliation: Department of Surgery, Division of Surgical Oncology, Boston, MA 02114, USA.
authors.forename: Sara H
authors.initials: SH
authors.lastname: Javid
authors.forename: Laurie J
authors.initials: LJ
authors.lastname: Kirstein
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Rafferty
authors.forename: Stuart
authors.initials: S
authors.lastname: Lipsitz
authors.forename: Richard
authors.initials: R
authors.lastname: Moore
authors.forename: Jennifer E
authors.initials: JE
authors.lastname: Rusby
authors.forename: Colleen D
authors.initials: CD
authors.lastname: Murphy
authors.forename: Kevin S
authors.initials: KS
authors.lastname: Hughes
authors.forename: Michelle C
authors.initials: MC
authors.lastname: Specht
authors.forename: Alphonse G
authors.initials: AG
authors.lastname: Taghian
authors.forename: Barbara L
authors.initials: BL
authors.lastname: Smith
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000601:surgery*; D005260:Female; D006801:Humans; D015412:Mastectomy, Segmental / Q000295:instrumentation / Q000379:methods*; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local; D011859:Radiography; D012189:Retrospective Studies; D016896:Treatment Outcome