title: Multiple mechanisms for hydrogen peroxide-induced apoptosis.
abstract: The mechanisms of cell killing by oxidative stress, in particular by hydrogen peroxide, are not yet well clarified. Here, we show that during recovery after H(2)O(2) treatment, apoptosis occurs in two different waves, peaking at 8 h (early) and 18 h (late) of recovery from oxidative stress. The two peaks are differentially modulated by a set of inhibitors of metabolic processes, which suggests that the first peak depends on DNA break formation, whereas the second may be correlated with H(2)O(2)-induced mitochondrial alterations.
authors.affiliation: Department of Biology, Tor Vergata University, Rome, Italy.
authors.forename: Claudia
authors.initials: C
authors.lastname: Cerella
authors.forename: Simona
authors.initials: S
authors.lastname: Coppola
authors.forename: Vittoria
authors.initials: V
authors.lastname: Maresca
authors.forename: Milena
authors.initials: M
authors.lastname: De Nicola
authors.forename: Flavia
authors.initials: F
authors.lastname: Radogna
authors.forename: Lina
authors.initials: L
authors.lastname: Ghibelli
mesh_terms: D019797:3-Iodobenzylguanidine / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects*; D001549:Benzamides / Q000494:pharmacology; D053938:DNA Fragmentation / Q000187:drug effects; D003847:Deoxyglucose / Q000494:pharmacology; D006146:Guanidines / Q000494:pharmacology; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D008856:Microscopy, Fluorescence; D016877:Oxidants / Q000494:pharmacology*; D013997:Time Factors; D020298:U937 Cells
chemical_list: D001549:Benzamides; D006146:Guanidines; D016877:Oxidants; C117872:benzylguanidine; D019797:3-Iodobenzylguanidine; C025160:3-aminobenzamide; D003847:Deoxyglucose; D006861:Hydrogen Peroxide