Concomitant Aspergillus and Cytomegalovirus infection in heart transplant: early diagnosis is the key to successful treatment.
Concomitant infections, which are common in patients who have received an organ transplant, must be diagnosed and treated early to prevent high mortality rates. We describe a case of concomitant Cytomegalovirus infection and Aspergillus pneumonia in a heart transplant patient who received pulsed steroids as therapy for rejection, and we describe the successful treatment of that coinfection with ganciclovir and voriconazole.
Tigen
Elif
E
Marmara University Medical School, Infectious Disease and Clinical Microbiology Department, Istanbul, Turkey.
Tigen
Kursat
K
Karaahmet
Tansu
T
Odabasi
Zekaver
Z
Korten
Volkan
V
D000208:Acute Disease; D000935:Antifungal Agents / Q000627:therapeutic use*; D000998:Antiviral Agents / Q000627:therapeutic use*; D002311:Cardiomyopathy, Dilated / Q000601:surgery; D003586:Cytomegalovirus Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000821:virology; D042241:Early Diagnosis; D015774:Ganciclovir / Q000627:therapeutic use; D006084:Graft Rejection / Q000188:drug therapy* / Q000276:immunology; D016027:Heart Transplantation / Q000009:adverse effects*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects*; D055744:Invasive Pulmonary Aspergillosis / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D009894:Opportunistic Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology / Q000821:virology; D020551:Pulse Therapy, Drug; D011743:Pyrimidines / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014230:Triazoles / Q000627:therapeutic use; D065819:Voriconazole
D000935:Antifungal Agents; D000998:Antiviral Agents; D007166:Immunosuppressive Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole; D015774:Ganciclovir