The yin-yang of tumor-associated neutrophils.
Cancer-related inflammation is a key component of the tumor microenvironment. A report in this issue of Cancer Cell now indicates that tumor-associated neutrophils in lung cancer can polarize to either "N1" or "N2" phenotype that inhibits or promotes cancer development, respectively.
Mantovani
Alberto
A
Istituto Clinico Humantas IRCCS and Department of Translational Medicine, University of Milan, Milan, Italy. alberto.mantovani@humanitas.it
D000818:Animals; D002289:Carcinoma, Non-Small-Cell Lung / Q000276:immunology* / Q000473:pathology; D008175:Lung Neoplasms / Q000276:immunology* / Q000473:pathology; D051379:Mice; D009504:Neutrophils / Q000276:immunology* / Q000473:pathology; D055752:Small Cell Lung Carcinoma / Q000276:immunology* / Q000473:pathology; D016709:Yin-Yang