[Impact of antioxidative therapy on state of enzymic redox-system of glutathione in patients with phlegmons of maxillofacial area].
Traditional and antioxidative therapy (retinol and alpha-tocopherol) was done by therapeutic course to 18 patients with phlegmons of maxillofacial region. In the peripheral blood leucocytes and tissues (skin, muscle) of the patients with phlegmons there were determined glutathione reductase activity, glutathione peroxidase activity and content of glutathione. Disbalance of glutathione enzyme redox system in leucocytes of patients with phlegmons was corrected by comprehensive therapy after 1 week. Spirman's correlation analysis showed positive correlation between glutathione depended enzymes in skin and muscle of patient with phlegmons before and after therapeutic course.
Gavriliuk
L A
LA
Shcherbatiuk
D I
DI
Lungu
S E
SE
D000328:Adult; D000975:Antioxidants / Q000008:administration & dosage / Q000627:therapeutic use*; D002481:Cellulitis / Q000188:drug therapy* / Q000201:enzymology*; D004338:Drug Combinations; D005148:Facial Dermatoses / Q000188:drug therapy* / Q000201:enzymology*; D005979:Glutathione Peroxidase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D006801:Humans; D007568:Jaw; D007962:Leukocytes / Q000201:enzymology; D008875:Middle Aged; D009132:Muscles / Q000201:enzymology; D010084:Oxidation-Reduction; D012867:Skin / Q000201:enzymology; D013997:Time Factors; D014801:Vitamin A / Q000008:administration & dosage / Q000627:therapeutic use*; D014810:Vitamin E / Q000008:administration & dosage / Q000627:therapeutic use; D014815:Vitamins / Q000008:administration & dosage / Q000627:therapeutic use*; D024502:alpha-Tocopherol / Q000008:administration & dosage / Q000627:therapeutic use*
D000975:Antioxidants; D004338:Drug Combinations; D014815:Vitamins; D014801:Vitamin A; D014810:Vitamin E; C048974:vitamin A, vitamin E drug combination; D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; D024502:alpha-Tocopherol