title: Increased risk for atherosclerosis of various macrophage scavenger receptor 1 alleles.
abstract: OBJECTIVE
  Macrophage scavenger receptor 1 (MSR1) mediates the uptake of modified low density lipoprotein (LDL)-cholesterol. The significance of MSR1 in atherosclerosis development in animal models is uncertain. In this study we sought to determine the significance of MSR1 polymorphisms in its encoding gene in susceptibility to atherosclerosis.
  
  
  METHODS
  We genotyped three polymorphic sites in the MSR1 gene including a 3-bp "TTA" insertion-deletion in intron 7 (rs3036811, Indel 7), an intron 5 SNP (rs33959637, IVS5-59), and a missense coding single nucleotide polymorphism (SNP) in exon 6 (rs3747531, P275A) in 136 nondiabetic Ashkenazi men under age 55 years (mean = 47.3 +/- 4.8 years) undergoing coronary angiography. Assessment of coronary disease was done by the number of segments with stenosis greater than 20% (coronary artery narrowing greater than 20% [CAGE > 20%]), greater than 50% (CAGE > 50%), and total number of diseased vessels. Linear regression modeling was used to define associations between atherosclerotic burden and MSR1 SNPs and haplotypes.
  
  
  RESULTS
  Significant associations were noted between IVS5-59 and number of diseased vessels (p = 0.009) and CAGE > 20% (p = 0.017), which remained significant upon controlling for age, cholesterol level, hypertension, and smoking.
  
  
  CONCLUSIONS
  This study demonstrates an association between MSR1 polymorphisms and atherosclerosis, suggesting that atherosclerotic risk associated with classic risk factors may be modified by MSR1 polymorphisms. These findings point to a significant role of MSR1 in atherosclerosis.
authors.affiliation: Department of Cardiology, Hadassah Hebrew University Medical Center, Jerusalem, Israel. rdurst@partners.org
authors.forename: Ronen
authors.initials: R
authors.lastname: Durst
authors.forename: Yehuda
authors.initials: Y
authors.lastname: Neumark
authors.forename: Vardiella
authors.initials: V
authors.lastname: Meiner
authors.forename: Yechiel
authors.initials: Y
authors.lastname: Friedlander
authors.forename: Nir
authors.initials: N
authors.lastname: Sharon
authors.forename: Arthur
authors.initials: A
authors.lastname: Polak
authors.forename: Ronen
authors.initials: R
authors.lastname: Beeri
authors.forename: Haim
authors.initials: H
authors.lastname: Danenberg
authors.forename: Gilli
authors.initials: G
authors.lastname: Erez
authors.forename: Shoshi
authors.initials: S
authors.lastname: Spitzen
authors.forename: Liat
authors.initials: L
authors.lastname: Ben-Avi
authors.forename: Eran
authors.initials: E
authors.lastname: Leitersdorf
authors.forename: Chaim
authors.initials: C
authors.lastname: Lotan
mesh_terms: D000328:Adult; D000483:Alleles; D050197:Atherosclerosis / Q000235:genetics*; D017023:Coronary Angiography; D005091:Exons; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D051117:Scavenger Receptors, Class A / Q000235:genetics*
chemical_list: C495139:MSR1 protein, human; D051117:Scavenger Receptors, Class A