title: [Natalizumab in multiple sclerosis].
abstract: BACKGROUND
  Natalizumab is a monoclonal antibody targeted against alpha-4 integrin that has proved to be very effective in the treatment of multiple sclerosis. The results of clinical trials published to date show a significant reduction in the rate of outbreaks and a decrease in the progression of the disability and of the disease activity as measured by means of magnetic resonance imaging. Natalizumab is well tolerated, although severe side effects have been reported that have conditioned its use as a second-line drug for the treatment of multiple sclerosis in patients who do not respond to conventional immunomodulators.
  
  
  CONCLUSIONS
  The latest data in patients with these characteristics continue to show that natalizumab still offers a very good effectiveness and safety profile. This review examines the latest data on the response to natalizumab in patients who fail to respond to therapy with conventional drugs.
authors.affiliation: Centre d'Esclerosi Múltiple de Catalunya, Hospital Universitari Vall d'Hebron, Barcelona, España. jrio@vhebron.net
authors.forename: J
authors.initials: J
authors.lastname: Río-Izquierdo
authors.forename: X
authors.initials: X
authors.lastname: Montalban
mesh_terms: D000911:Antibodies, Monoclonal / Q000009:adverse effects / Q000627:therapeutic use*; D061067:Antibodies, Monoclonal, Humanized; D006801:Humans; D009103:Multiple Sclerosis / Q000188:drug therapy*; D000069442:Natalizumab
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D000069442:Natalizumab