title: Medicines used in respiratory diseases only seen in children.
abstract: Detailed literature searches were carried out in seven respiratory disease areas. Therapeutic evidence for efficacy of medicinal products was assessed using the Grades of Recommendation, Assessment and Evaluation (GRADE) methodology, as well as an assessment of safety and side-effects. Systemic corticosteroids may reduce the development of bronchopulmonary dysplasia but have serious side-effects. Antioxidants need further study to demonstrate whether they have long-term benefits. Treatments for acute bronchiolitis have shown little benefit but new antiviral and monoclonal antibodies need further assessment. Well-constructed studies are needed to confirm the value of inhaled corticosteroids and/or montelukast in the management of viral-induced wheeze. Corticosteroids are the treatment of choice in croup. Minimal or no information is available for the treatment of congenital lung abnormalities, bronchiolitis obliterans and interstitial lung disease.
authors.affiliation: Dept of Child Health, University Hospital of North Staffordshire and Keele University, Stoke-on-Trent, UK. warren.lenney@uhns.nhs.uk
authors.forename: W
authors.initials: W
authors.lastname: Lenney
authors.forename: A L
authors.initials: AL
authors.lastname: Boner
authors.forename: L
authors.initials: L
authors.lastname: Bont
authors.forename: A
authors.initials: A
authors.lastname: Bush
authors.forename: K-H
authors.initials: KH
authors.lastname: Carlsen
authors.forename: E
authors.initials: E
authors.lastname: Eber
authors.forename: B
authors.initials: B
authors.lastname: Fauroux
authors.forename: M
authors.initials: M
authors.lastname: Götz
authors.forename: A
authors.initials: A
authors.lastname: Greenough
authors.forename: J
authors.initials: J
authors.lastname: Grigg
authors.forename: J
authors.initials: J
authors.lastname: Hull
authors.forename: J
authors.initials: J
authors.lastname: Kimpen
authors.forename: M
authors.initials: M
authors.lastname: Sánchez Luna
authors.forename: F M
authors.initials: FM
authors.lastname: de Benedictis
mesh_terms: D000367:Age Factors; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D000975:Antioxidants / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases; D008171:Lung Diseases / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D019141:Respiratory System Agents / Q000627:therapeutic use*
chemical_list: D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D019141:Respiratory System Agents