title: A case of histiocytic sarcoma diagnosed by bone marrow biopsy in a patient suffering from fever for 8 months.
abstract: Histiocytic sarcoma is a malignant proliferation of cells showing morphologic and immunophenotypic features similar to those of mature tissue histiocytes and is known for its rapid progression and poor prognosis. We describe a case of histiocytic sarcoma diagnosed by bone marrow biopsy. A 64-yr-old male was admitted for fever and weight loss that persisted for 8 months. The patient died undiagnosed on the 7th hospitalization day. A bone marrow biopsy performed just before the patient's death revealed diffuse proliferation of large pleomorphic neoplastic cells with large, round to oval nuclei, vesicular chromatin, and abundant foamy cytoplasm. These cells were positive for histiocytic markers, CD68, lysozyme, CD21, and S-100 protein, but negative for B-cell, T/NK-cell, and epithelial cell markers, thus confirming the presence of histiocytic sarcoma.
authors.affiliation: Department of Laboratory Medicine, Asan Medical Center and University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Yun Ha
authors.initials: YH
authors.lastname: Jang
authors.forename: Chan-Jeong
authors.initials: CJ
authors.lastname: Park
authors.forename: Joo Ryong
authors.initials: JR
authors.lastname: Huh
authors.forename: Seongsoo
authors.initials: S
authors.lastname: Jang
authors.forename: Hyun Sook
authors.initials: HS
authors.lastname: Chi
mesh_terms: D015703:Antigens, CD / Q000378:metabolism; D015214:Antigens, Differentiation, Myelomonocytic / Q000378:metabolism; D001853:Bone Marrow / Q000473:pathology*; D005334:Fever / Q000175:diagnosis; D054747:Histiocytic Sarcoma / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009113:Muramidase / Q000378:metabolism; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000378:metabolism; D009418:S100 Proteins / Q000378:metabolism; D014057:Tomography, X-Ray Computed; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D009113:Muramidase; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D009418:S100 Proteins; C067980:CD68 antigen, human; D000097382:CD68 Molecule