title: Getting to the root of BRCA1-deficient breast cancer.
abstract: Loss of BRCA1 has been shown to expand breast stem cells. In Nature Medicine, Lim et al. (2009) demonstrate that breast tissue from BRCA1 mutation carriers contains expanded luminal progenitor cells, suggesting a broader role for BRCA1 in mammary development.
authors.affiliation: Centre de Recherche en Cancérologie de Marseille, Laboratoire d'Oncologie Moléculaire, UMR891 Inserm/Institut Paoli-Calmettes, Marseille, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Ginestier
authors.forename: Suling
authors.initials: S
authors.lastname: Liu
authors.forename: Max S
authors.initials: MS
authors.lastname: Wicha
mesh_terms: D000818:Animals; D019313:BRCA1 Protein / Q000172:deficiency*; D001943:Breast Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D002454:Cell Differentiation; D004195:Disease Models, Animal; D005260:Female; D018628:Gene Dosage; D006801:Humans; D042361:Mammary Glands, Human / Q000166:cytology; D051379:Mice; D013234:Stem Cells / Q000166:cytology
chemical_list: D019313:BRCA1 Protein