Stem cells, stress, metabolism and cancer: a drama in two Octs.
It is a classic story of two related transcription factors. Oct4 is a potent regulator of pluripotency during early mammalian embryonic development, and is notable for its ability to convert adult somatic cells to pluripotency. The widely expressed Oct1 protein shares significant homology with Oct4, binds to the same sequences, regulates common target genes, and shares common modes of upstream regulation, including the ability to respond to cellular stress. Both proteins are also associated with malignancy, yet Oct1 cannot substitute for Oct4 in the generation of pluripotency. The molecular underpinnings of these phenomena are emerging, as are the consequences for adult stem cells and cancer, and thereby hangs a tale.
Kang
Jinsuk
J
Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA.
Shakya
Arvind
A
Tantin
Dean
D
D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D004734:Energy Metabolism; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism*; D050811:Octamer Transcription Factor-1 / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D050814:Octamer Transcription Factor-3 / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D010802:Phylogeny; D013234:Stem Cells / Q000502:physiology*; D013312:Stress, Physiological
D050811:Octamer Transcription Factor-1; D050814:Octamer Transcription Factor-3