Functional association between influenza A (H1N1) virus and human.
Influenza A (H1N1) virus is a severe threat worldwide. It is important to gain a better understanding of the mechanism of the infection. In the paper, we established a computational framework to investigate the crosstalk between the virus and the host, by finding out the proteins that the virus is attacking. The targeted proteins were predicted by taking human proteins laid on the same GO functions or processes as the virus proteins. One hundred and one core proteins were identified. The results provide some knowledge of the possible biological processes and molecular interactions caused by the viral infection, including the host responses.
Huang
Tao
T
Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, PR China.
Cui
WeiRen
W
He
Zhi-Song
ZS
Hu
Lele
L
Liu
Fang
F
Wen
TieQiao
T
Li
Yixue
Y
Cai
Yudong
Y
D003198:Computer Simulation; D054884:Host-Pathogen Interactions; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000378:metabolism*; D007251:Influenza, Human / Q000378:metabolism* / Q000821:virology*; D008954:Models, Biological; D014758:Viral Core Proteins / Q000235:genetics / Q000378:metabolism*
D014758:Viral Core Proteins