Corneal thickness association with ocular and corneal high-order aberrations.
OBJECTIVE
To investigate the association among central corneal thickness, peripheral corneal thickness (PCT), and wavefront aberrations in the anterior cornea, posterior cornea and the whole eye in myopia.


METHODS
Sixty-four eyes of 64 myopic subjects were evaluated with a Pentacam rotating Scheimpflug camera (Oculus, Inc., WA) corneal topographer for: (1) wavefront aberrations from the anterior and posterior corneal surface, (2) corneal thickness (central and peripheral), and (3) with a wavefront aberration-supported cornea ablation wavefront analyzer (Wavescan, Visx, Inc., Santa Clara, CA) for wavefront aberrations generated in the whole eye. Relationships between the wavefront aberrations and corneal thickness were analyzed.


RESULTS
The mean age of subjects was 34.75 +/- 10.08 years. The central corneal thickness was 550.5 +/- 28.459 microm. The mean peripheral thickness was 629.9 +/- 32.1 microm. Central and PCTs were not significantly correlated with corneal or ocular high-order aberrations. Intraocular pressure was significantly correlated with ocular trefoil (r = -0.307, P=0.001).


CONCLUSIONS
Central and PCT were not significantly associated with either anterior or posterior corneal Zernike aberrations; in addition, no association with the whole ocular wavefront aberrations was found.
Mohamed
Engy M
EM
Ophthalmology Department, University of Texas Southwestern Medical Center at Dallas, 75390-9057, USA.
Wojtowicz
Jadwiga C
JC
Bowman
Wayne
W
Cavanagh
H Dwight
HD
Mootha
Vinod
V
Verity
Steven
S
McCulley
James P
JP
D000328:Adult; D000367:Age Factors; D003315:Cornea / Q000473:pathology*; D019781:Corneal Topography; D057108:Corneal Wavefront Aberration / Q000150:complications* / Q000473:pathology*; D005123:Eye / Q000473:pathology*; D005260:Female; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D009216:Myopia / Q000473:pathology* / Q000503:physiopathology