title: Side-alternating vibration training improves muscle performance in a patient with late-onset pompe disease.
abstract: Side-alternating vibration training (SAVT) was used for 15 weeks in a patient with Late-onset Pompe disease who had never used enzyme replacement or chaperone therapy. Prior to the use of SAVT, the patient had experienced declining muscle performance and her 6-minute walk distance decreased from 210 to 155 metres in 6 months. After SAVT, her 6-minute walk distance increased 70% from 166 to 282 metres, muscle jumping power increased by 64% from 83 to 166 watts, isometric knee extensor strength increased 17% from 38 to 44 Nm, and she achieved a more normal pattern of ankle, knee, and joint kinematics and kinetics. Her functional ability measured through the Rotterdam 9-item score was unchanged at 19/36. There were no elevations in serum creatine kinase or lactate. This is the first report, to our knowledge, of a performance improvement in a patient with Pompe disease using SAVT.
authors.affiliation: Medical Genetics and Pediatrics, Alberta Children's Hospital, University of Calgary, 3rd Floor, 2888 Shaganappi Trail NW, Calgary, AB, Canada T3B 6A8.
authors.forename: Aneal
authors.initials: A
authors.lastname: Khan
authors.forename: Barbara
authors.initials: B
authors.lastname: Ramage
authors.forename: Ion
authors.initials: I
authors.lastname: Robu
authors.forename: Laura
authors.initials: L
authors.lastname: Benard