How well do pre- and peritransplant variables predict the long-term results of kidney transplantation?
In organ transplantation, several clinical risk factors that are available before or immediately following the time of surgery have been shown to affect long-term transplant outcomes. We examined their ability to predict long-term survival accurately using a novel statistical method and data from the Données Informatisees et Validées en Transplantation on 3,227 kidney transplant recipients between 1996-2006 at 5 French transplant centers. The results clearly illustrate that the correlation of these parameters with survival is not sufficient to constitute a prognostic marker. In kidney transplantation, classical pre- and peritransplant clinical risk factors of graft loss are poor predictive markers for medical decision-making.
Foucher
Yohann
Y
ITERT IUN and INSERM U643, CHU de Nantes, Université de Nantes, France.
Daguin
Pascal
P
Kessler
Michèle
M
Ladriere
Marc
M
Legendre
Christophe
C
Kreis
Henri
H
Durand
Dominique
D
Laveyssiere
Laurence
L
Mourad
Georges
G
Garrigue
Valérie
V
Soulillou
Jean-Paul
JP
Giral
Magali
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006084:Graft Rejection / Q000209:etiology / Q000517:prevention & control*; D006085:Graft Survival; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D011237:Predictive Value of Tests; D012372:ROC Curve; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors; D017211:Treatment Failure; D055815:Young Adult