Delivery and efficacy of a cancer drug as a function of the bond to the gold nanoparticle surface.
In this feature article, gold nanoparticle conjugates loaded with phthalocyanine-based PDT drugs are prepared and tested for delivery efficiency and PDT efficacy on HeLa cancer cells. It could be shown that the delivery and PDT outcome are strongly affected by the bond that links the drug load to the nanoparticle surface. Whereas labile amino adsorption to the Au nanoparticle surface allows for efficient drug release into the cancer cells and for efficient PDT, a covalent thiol bond to the Au nanoparticle leads to the delivery of the drug into cell vesicles, and no PDT effect is observed. This work highlights the importance of carefully choosing the interaction between drug molecules and the nanoparticle surface.
Cheng
Yu
Y
Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106, USA.
Samia
Anna C
AC
Li
Jun
J
Kenney
Malcolm E
ME
Resnick
Andrew
A
Burda
Clemens
C
D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D001665:Binding Sites; D002470:Cell Survival / Q000187:drug effects; D020099:Coated Materials, Biocompatible / Q000737:chemistry* / Q000494:pharmacology; D016503:Drug Delivery Systems; D004354:Drug Screening Assays, Antitumor; D006046:Gold / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry*; D010778:Photochemotherapy; D012821:Silanes / Q000737:chemistry* / Q000494:pharmacology; D013499:Surface Properties; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D020099:Coated Materials, Biocompatible; D012821:Silanes; D006046:Gold; C052464:bis(tri-n-hexylsiloxy)(2,3-naphthalocyaninato)silicon