title: Fyn kinase function in lipid utilization: a new upstream regulator of AMPK activity?
abstract: The balance of cellular energy levels in response to changes of nutrient availability, stress stimuli or exercise is a critical step in maintaining tissue and whole body homeostasis. Disruption of this balance is associated with various pathologies, including the metabolic syndrome. Recently, accumulating evidence has demonstrated that the AMP-activated protein kinase (AMPK) plays a central role in sensing changes in energy levels. The regulation of AMPK activity is currently the subject of significant investigation since this enzyme is a potential therapeutic target in both metabolic disorders and tumorigenesis. In this review, we present novel evidence of crosstalk between Fyn, one member of the Src kinase family, and AMPK.
authors.affiliation: Albert Einstein College of Medicine, Diabetes Research and Training Center, Department of Medicine, Bronx, NY 10461, USA.
authors.forename: Manu
authors.initials: M
authors.lastname: Vatish
authors.forename: Eijiro
authors.initials: E
authors.lastname: Yamada
authors.forename: Jeffrey E
authors.initials: JE
authors.lastname: Pessin
authors.forename: Claire C
authors.initials: CC
authors.lastname: Bastie
mesh_terms: D000263:Adenylate Kinase / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000378:metabolism; D050356:Lipid Metabolism; D010084:Oxidation-Reduction; D011487:Protein Conformation; D051076:Proto-Oncogene Proteins c-fyn / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D007328:Insulin; C494957:FYN protein, human; D051076:Proto-Oncogene Proteins c-fyn; D000263:Adenylate Kinase