Natriuretic peptides: useful biomarkers in predicting the possibility of restoration and maintenance of sinus rhythm in patients with atrial fibrillation undergoing cardioversion?
Natriuretic peptides (NPs) have been regarded as of diagnostic and prognostic importance in a variety of clinical conditions including congestive heart failure (CHF). Paroxysmal and persistent atrial fibrillations (AFs) have been reported to be associated with high plasma levels of NPs that decline after restoration of sinus rhythm. Rhythm control of AF largely depends on the duration of the arrhythmia and the presence of underlying structural heart disease that may exert negative effects on the restoration and maintenance of sinus rhythm. AFs associated with structural heart disease or AFs of long duration may also be associated with disproportionately high plasma NP levels probably due to the outstanding increases in myocardial wall stretch, volume and pressure overload leading to significant NP release. Therefore, very high levels of baseline NP levels may be associated with lower rates of successful cardioversion and higher rates of AF recurrence on follow-up. It may be suggested that baseline NP levels may predict the possibility of successful rhythm control, and hence may help determine the appropriate therapeutic strategy (rhythm or rate control) in patients with AF.
Yalta
Kenan
K
Cumhuriyet University, Cardiology Department, Sivas, 58100, Turkey. Electronic address: kyalta@gmail.com.
Yilmaz
Mehmet Birhan
MB
Cumhuriyet University, Cardiology Department, Sivas, 58100, Turkey.
Turgut
Okan Onur
OO
Cumhuriyet University, Cardiology Department, Sivas, 58100, Turkey.
Tandogan
Izzet
I
Cumhuriyet University, Cardiology Department, Sivas, 58100, Turkey.
D001281:Atrial Fibrillation / Q000097:blood* / Q000628:therapy; D015415:Biomarkers / Q000097:blood; D004554:Electric Countershock / Q000379:methods; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D045265:Natriuretic Peptides / Q000097:blood*; D011237:Predictive Value of Tests
D015415:Biomarkers; D045265:Natriuretic Peptides