title: Antioxidant action of sugar-pendant C60 fullerenes.
abstract: The action of C60 fullerene and its derivatives as a radical-scavenging antioxidant has received much attention, but their reactivity toward free radicals and antioxidant capacity have not been well elucidated yet. In the present study, the reactivity of the two types of water-soluble, sugar-pendant C60 fullerenes, C60-1S and C60-2S, toward peroxyl radical and their effect against human plasma lipid peroxidation were measured. The rate constants for the reaction of C60-1S and C60-2S with peroxyl radicals were obtained from their effect on the bleaching of beta-carotene in lipid-SDS micelle system as 4.6 x 10(3) and 8.0 x 10(3) M(-1) s(-1) at 37 degrees C, respectively. They inhibited the free radical-induced lipid peroxidation in human plasma in a concentration-dependent manner. These results suggest that the sugar-pendant fullerenes C60-1S and C60-2S act as a radical-scavenging antioxidant with the activity similar to the phenolic antioxidants.
authors.affiliation: Health Technology Research Center, National Institute of Advanced Industrial Science and Technology, 1-8-31 Midorigaoka, Ikeda, Osaka 563-8577, Japan.
authors.forename: Masanori
authors.initials: M
authors.lastname: Horie
authors.forename: Akiko
authors.initials: A
authors.lastname: Fukuhara
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Saito
authors.forename: Yasukazu
authors.initials: Y
authors.lastname: Yoshida
authors.forename: Hiroe
authors.initials: H
authors.lastname: Sato
authors.forename: Hiromi
authors.initials: H
authors.lastname: Ohi
authors.forename: Makoto
authors.initials: M
authors.lastname: Obata
authors.forename: Yuji
authors.initials: Y
authors.lastname: Mikata
authors.forename: Shigenobu
authors.initials: S
authors.lastname: Yano
authors.forename: Etsuo
authors.initials: E
authors.lastname: Niki
mesh_terms: D004187:Disaccharides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000737:chemistry* / Q000494:pharmacology; D037741:Fullerenes / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D007700:Kinetics; D015227:Lipid Peroxidation / Q000187:drug effects; D019207:beta Carotene / Q000378:metabolism
chemical_list: D004187:Disaccharides; D016166:Free Radical Scavengers; D037741:Fullerenes; D019207:beta Carotene