Cytogenetic analysis of a primary bone angiosarcoma.
Primary bone angiosarcomas are rare and aggressive vascular malignancies with a high mortality rate. To our knowledge, there are no reported cytogenetic abnormalities in primary bone angiosarcomas, although several have been reported in soft tissue angiosarcomas. We report a case of primary bone angiosarcoma, arising in the tibia of a 79-year-old woman, with a unique clonal chromosomal rearrangement: t(1;14)(p21;q24), that has not been reported in either soft tissue or primary bone angiosarcoma. The biologic significance of this translocation is not clear; however, the 1p21 locus is in the region of colony stimulating factor (CSF-1), which may play a role in tumorigenesis, as has been described in pigmented villonodular synovitis and tenosynovial giant cell tumor.
Dunlap
Jennifer B
JB
Department of Pathology, Oregon Health and Sciences University, 3181 S.W. Sam Jackson Park Road, Portland, OR 97239, USA.
Magenis
R Ellen
RE
Davis
Craig
C
Himoe
Eleanor
E
Mansoor
Atiya
A
D000368:Aged; D001859:Bone Neoplasms / Q000235:genetics* / Q000473:pathology; D002871:Chromosome Banding; D019457:Chromosome Breakage; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics; D002883:Chromosomes, Human, Pair 14 / Q000235:genetics; D020732:Cytogenetic Analysis; D005260:Female; D006394:Hemangiosarcoma / Q000235:genetics* / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D013977:Tibia / Q000378:metabolism / Q000473:pathology; D014178:Translocation, Genetic