Lack of association between lymphotoxin-alpha, galectin-2 polymorphisms and coronary artery disease: a meta-analysis.
OBJECTIVE
Previous case-control studies suggested the single nucleotide polymorphisms of lymphotoxin-alpha (LTA) gene and galectin-2 (LGASL2) gene are associated with coronary artery disease and myocardial infarction. However, other studies did not confirm this relationship. The objective was to assess the relationship of LTA gene, LGALS2 gene and coronary artery disease, using a meta-analysis.


METHODS
Databases, including PubMed, EMbase, CBM and CNKI, were searched to get the genetic association studies. Data were extracted by two authors and pooled odds ratio (OR) and 95% confidence interval (CI) were calculated.


RESULTS
The meta-analysis included 20640 (LTA-A252G) and 10552 (LGALS2-C3279T) cases, 15388 (A252G) and 10545 (C3279T) controls. The pooled OR of 252G was 1.02 (95%CI: 0.97-1.07) compared to wild type allele in dominant model, and was 1.00 (95%CI: 0.94-1.07) in recessive model. The pooled OR of 3279T was 0.95 (95%CI: 0.89-1.01) compared to wild type allele in dominant model, and was 0.89 (95%CI: 0.78-1.00) in recessive model. None of the polymorphisms was found to associate with coronary artery disease.


CONCLUSIONS
In present study, the LTA gene and LGALS2-C3279T are not associated with coronary artery disease.
Li
Wenlong
W
Key Laboratory for Clinical Cardiovascular Genetics, Ministry of Education, Sino-German Laboratory for Molecular Medicine, Cardiovascular Institute, Fu Wai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, 167 Beilishi Road, Beijing 100037, PR China.
Xu
Jing
J
Wang
Xiaojian
X
Chen
Jingzhou
J
Zhang
Channa
C
Sun
Kai
K
Hui
Rutai
R
D000483:Alleles; D003324:Coronary Artery Disease / Q000235:genetics*; D005260:Female; D037501:Galectin 2 / Q000235:genetics*; D005799:Genes, Dominant; D005808:Genes, Recessive; D020022:Genetic Predisposition to Disease; D006801:Humans; D008233:Lymphotoxin-alpha / Q000235:genetics*; D008297:Male; D016017:Odds Ratio; D011110:Polymorphism, Genetic
D037501:Galectin 2; D008233:Lymphotoxin-alpha