Cultured bilayered skin allograft for vaginal construction.
OBJECTIVE
This is the first report of live human cultured bilayered skin allograft (taken from another person) (LHCBSA) to line a dissected space to create a vagina.


METHODS
A 19-year-old with Mayer-Rokitansky-Küster-Hauser syndrome (MRKH syndrome) of vaginal and uterine agenesis had a space dissected and lined with LHCBSA. Although the lining devitalized within 2 weeks, there was a rapid ingrowth of vaginal mucosal cells from the vaginal dimple with an excellent long-term result.


CONCLUSIONS
This is the first report that LHCBSA is able to stimulate vaginal mucosal cell growth for a neovagina. It is possible that it might stimulate other surface tissue lining to cover adjacent raw areas such as bladder or esophagus.
Altchek
Albert
A
Department of Obstetrics, Gynecology and Reproductive Science, Mount Sinai School of Medicine and Hospital, New York, NY, USA. albertaltchek@aol.com
Hanflik
Andrew
A
Deligdisch
Liane
L
Brem
Harold
H
D005260:Female; D013509:Gynecologic Surgical Procedures / Q000379:methods*; D006801:Humans; D016038:Skin Transplantation / Q000379:methods*; D015607:Stents; D013577:Syndrome; D046509:Tissue Culture Techniques; D014184:Transplantation, Homologous / Q000379:methods; D014599:Uterus / Q000002:abnormalities*; D014621:Vagina / Q000002:abnormalities* / Q000601:surgery*; D055815:Young Adult