Neurosarcoidosis presenting as Guillain-Barré-like syndrome. A case report and review of the literature.
Sarcoidosis is a multisystem inflammatory disease that can affect the nervous system. Cranial neuropathies are the most frequent presentation of neurosarcoidosis. Involvement of the peripheral nervous system is less common. The presentation is usually subacute or chronic sensorimotor axonal polyneuropathy, whereas acute polyradiculopathy is extremely rare. We report a case of Guillain-Barré-like syndrome probably secondary to sarcoidosis. A review of the literature revealed 9 similar cases. The possibility of a Guillain-Barré-like syndrome as a presenting symptom of sarcoidosis should be considered, especially in patients with atypical features such as cerebrospinal fluid pleocytosis.
Fahoum
Firas
F
Department of Neurology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. ffahoum@gmail.com
Drory
Vivian E
VE
Issakov
Josephine
J
Neufeld
Miri Y
MY
D003680:Deglutition Disorders / Q000209:etiology / Q000503:physiopathology; D003937:Diagnosis, Differential; D018450:Disease Progression; D004568:Electrodiagnosis; D005260:Female; D006099:Granuloma / Q000276:immunology / Q000473:pathology; D020275:Guillain-Barre Syndrome / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D008198:Lymph Nodes / Q000276:immunology / Q000473:pathology; D008775:Methylprednisolone / Q000008:administration & dosage; D008875:Middle Aged; D018908:Muscle Weakness / Q000209:etiology / Q000503:physiopathology; D009431:Neural Conduction / Q000187:drug effects / Q000502:physiology; D009460:Neurologic Examination; D010525:Peripheral Nerves / Q000473:pathology / Q000503:physiopathology; D011115:Polyneuropathies / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D011782:Quadriplegia / Q000209:etiology / Q000503:physiopathology; D012121:Respiration, Artificial; D012507:Sarcoidosis / Q000150:complications* / Q000175:diagnosis* / Q000503:physiopathology; D012678:Sensation Disorders / Q000209:etiology / Q000503:physiopathology; D013997:Time Factors; D016896:Treatment Outcome
D007166:Immunosuppressive Agents; D008775:Methylprednisolone