title: Bacteremia with a large clostridial toxin-negative, binary toxin-positive strain of Clostridium difficile.
abstract: Bacteremia caused by Clostridium difficile is rare. In this report, we describe a case of C. difficile bacteremia caused by an unusual strain of C. difficile. The isolate contained neither toxin A nor B genes, however, binary toxin genes were present (tcdA(-), tcdB(-), cdtA(+), cdtB(+)) and a 7.2-kb element unrelated to the PaLoc was found inserted within the PaLoc integration site. The clinical relevance of the isolate could not be determined.
authors.affiliation: Microbiology & Immunology, The University of Western Australia, Western Australia, Australia.
authors.forename: Briony
authors.initials: B
authors.lastname: Elliott
authors.forename: Robert
authors.initials: R
authors.lastname: Reed
authors.forename: Barbara J
authors.initials: BJ
authors.lastname: Chang
authors.forename: Thomas V
authors.initials: TV
authors.lastname: Riley
mesh_terms: D036002:ADP Ribose Transferases / Q000235:genetics / Q000378:metabolism; D000328:Adult; D016470:Bacteremia / Q000175:diagnosis* / Q000382:microbiology*; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D001427:Bacterial Toxins / Q000235:genetics / Q000378:metabolism; D016360:Clostridioides difficile / Q000145:classification / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity*; D004761:Enterocolitis, Pseudomembranous / Q000382:microbiology; D004768:Enterotoxins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008297:Male
chemical_list: D001426:Bacterial Proteins; D001427:Bacterial Toxins; D004768:Enterotoxins; C041348:tcdA protein, Clostridium difficile; C031815:toxB protein, Clostridium difficile; D036002:ADP Ribose Transferases; C410164:actin-specific ADP-ribosyltransferase, Clostridium