title: Association of gene polymorphisms with chronic kidney disease in Japanese individuals.
abstract: Chronic kidney disease (CKD) is recognized as a risk factor not only for end-stage renal disease but also for cardiovascular disease. Early detection and treatment of CKD is a likely key factor for prevention of its complications. Although genetic linkage analyses and association studies have implicated several loci and candidate genes in predisposition to CKD, the genes that underlie genetic susceptibility to this condition have remained largely unknown. The purpose of the present study was to identify genetic variants that confer susceptibility to CKD in Japanese individuals. The study population comprised 4,829 Japanese individuals (2,697 men, 2,132 women), including 757 subjects with CKD [464 men, 293 women; estimated glomerular filtration rate (eGFR) <50 ml min 1.73 m(-2)] and 4,072 controls (2,233 men, 1,839 women; eGFR >or=60 ml min 1.73 m(-2)). The genotypes for 40 polymorphisms of 39 candidate genes were determined. The chi-square test, multivariable logistic regression analysis with adjustment for covariates, as well as a stepwise forward selection procedure revealed that six polymorphisms of F10, PITRM1, PCSK2, JPH3, MYO7B, and AKAP12 were related (P<0.05) to the prevalence of CKD. Among these polymorphisms, the Cright curved arrow T polymorphism of F10 (rs5962) was most significantly associated with this condition. Determination of genotypes for the Cright curved arrow T polymorphism of F10 may prove informative for assessment of genetic risk for CKD in Japanese individuals.
authors.affiliation: Department of Cardiovascular Medicine, Inabe General Hospital, Inabe, Japan.
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Yoshida
authors.forename: Kimihiko
authors.initials: K
authors.lastname: Kato
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Yokoi
authors.forename: Mitsutoshi
authors.initials: M
authors.lastname: Oguri
authors.forename: Sachiro
authors.initials: S
authors.lastname: Watanabe
authors.forename: Norifumi
authors.initials: N
authors.lastname: Metoki
authors.forename: Hidemi
authors.initials: H
authors.lastname: Yoshida
authors.forename: Kei
authors.initials: K
authors.lastname: Satoh
authors.forename: Yukitoshi
authors.initials: Y
authors.lastname: Aoyagi
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Nozawa
authors.forename: Yoshiji
authors.initials: Y
authors.lastname: Yamada
mesh_terms: D054758:A Kinase Anchor Proteins / Q000235:genetics; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D018797:Cell Cycle Proteins / Q000235:genetics; D002908:Chronic Disease; D005260:Female; D045683:Furin / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D007674:Kidney Diseases / Q000235:genetics*; D008297:Male; D008666:Metalloendopeptidases / Q000235:genetics; D008875:Middle Aged; D009218:Myosins / Q000235:genetics; D011110:Polymorphism, Genetic / Q000235:genetics*
chemical_list: D054758:A Kinase Anchor Proteins; C491162:AKAP12 protein, human; D018797:Cell Cycle Proteins; D045683:Furin; D008666:Metalloendopeptidases; C119694:PITRM1 protein, human; D009218:Myosins