title: Integron class 1 reservoir among highly resistant gram-negative microorganisms recovered at a Dutch teaching hospital.
abstract: Integrons play an important role in the dissemination of resistance genes among bacteria. Nearly 70% of highly resistant gram-negative bacteria isolated at a tertiary care hospital harbored an integron. Epidemiologic analysis suggests that horizontal gene transfer is an important mechanism of resistance spread and has a greater contribution than cross-transmission to levels of resistance in settings where highly resistant gram-negative bacteria are endemic.
authors.affiliation: Department of Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam.
authors.forename: Marlies J
authors.initials: MJ
authors.lastname: Mooij
authors.forename: Ina
authors.initials: I
authors.lastname: Willemsen
authors.forename: Marilie
authors.initials: M
authors.lastname: Lobbrecht
authors.forename: Christina
authors.initials: C
authors.lastname: Vandenbroucke-Grauls
authors.forename: Jan
authors.initials: J
authors.lastname: Kluytmans
authors.forename: Paul H M
authors.initials: PH
authors.lastname: Savelkoul
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D022761:Gene Transfer, Horizontal; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D016905:Gram-Negative Bacterial Infections / Q000453:epidemiology* / Q000382:microbiology; D006784:Hospitals, Teaching / Q000706:statistics & numerical data*; D006801:Humans; D019426:Integrases / Q000235:genetics; D032023:Integrons / Q000235:genetics*; D007362:Intensive Care Units; D008826:Microbial Sensitivity Tests; D009426:Netherlands / Q000453:epidemiology; D015995:Prevalence
chemical_list: D000900:Anti-Bacterial Agents; D019426:Integrases