title: Imaging features of hepatic angiomyolipomas on real-time contrast-enhanced ultrasound.
abstract: The aim of this study was to evaluate the imaging features of hepatic angiomyolipoma (AML) on contrast-enhanced ultrasound (CEUS). The imaging features of 12 pathologically proven hepatic AML lesions in 10 patients who had undergone baseline ultrasound (BUS) and CEUS examinations were evaluated retrospectively. The enhancement extent, pattern and dynamic change, along with the enhancement process, on CEUS were analysed. The diagnostic results of BUS and CEUS before pathological examination were also recorded. The results showed that 75% (9/12) of the AML lesions exhibited mixed echogenicity on BUS and most showed remarkable hyperechogenicity in combination with a hypoechoic or anechoic portion. Arterial flow signals were detected in 75% (9/12) of the lesions on colour Doppler imaging. On CEUS, 66.7% (n = 8) of the 12 lesions exhibited hyperenhancement in the arterial phase, slight hyperenhancement (n = 2) or isoenhancement (n = 6) in the portal phase, and slight hyperenhancement (n = 1) or isoenhancement (n = 7) in the late phase. Three (25%) lesions exhibited hyperenhancement in the arterial phase and hypoenhancement in both portal and late phases. One (8.3%) lesion exhibited hypoenhancement throughout the CEUS process. Before pathological examination with BUS, only 3 (25%) lesions were correctly diagnosed as hepatic AML. Conversely, on CEUS, correct diagnoses were made for 66.8% (8/12) of hepatic AMLs. Therefore, arterial hyperenhancement and subsequent sustained enhancement on CEUS were found in the majority of hepatic AMLs. The combination of BUS and CEUS leads to the correct diagnosis in the majority of hepatic AMLs, and is higher than the success rate achieved by BUS alone.
authors.affiliation: Department of Medical Ultrasonics, The First Affiliated Hospital, Institute of Diagnostic and Interventional Ultrasound, Sun Yat-Sen University, Guangzhou, China.
authors.forename: Z
authors.initials: Z
authors.lastname: Wang
authors.forename: H-X
authors.initials: HX
authors.lastname: Xu
authors.forename: X-Y
authors.initials: XY
authors.lastname: Xie
authors.forename: X-H
authors.initials: XH
authors.lastname: Xie
authors.forename: M
authors.initials: M
authors.lastname: Kuang
authors.forename: Z-F
authors.initials: ZF
authors.lastname: Xu
authors.forename: G-J
authors.initials: GJ
authors.lastname: Liu
authors.forename: L-D
authors.initials: LD
authors.lastname: Chen
authors.forename: M-X
authors.initials: MX
authors.lastname: Lin
authors.forename: M-D
authors.initials: MD
authors.lastname: Lu
mesh_terms: D000328:Adult; D018207:Angiomyolipoma / Q000000981:diagnostic imaging*; D003287:Contrast Media; D005260:Female; D006801:Humans; D007089:Image Enhancement; D008113:Liver Neoplasms / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D012079:Renal Circulation; D012189:Retrospective Studies; D018615:Ultrasonography, Doppler, Color / Q000379:methods
chemical_list: D003287:Contrast Media