title: Enzyme-instructed molecular self-assembly confers nanofibers and a supramolecular hydrogel of taxol derivative.
abstract: By covalently connecting taxol with a motif that is prone to self-assemble, we successfully generate the precursor (5a), the hydrogelator (5b), and hydrogel of a taxol derivative without compromising the cytotoxic activity of the taxol. This approach promises a general method to create nanofibers of therapeutic molecules that have a dual role, as both the delivery vehicle and the drug itself.
authors.affiliation: Department of Chemistry, Brandeis University, 415 South Street, Waltham, Massachusetts 02454, USA.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Gao
authors.forename: Yi
authors.initials: Y
authors.lastname: Kuang
authors.forename: Zu-Feng
authors.initials: ZF
authors.lastname: Guo
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Guo
authors.forename: Isaac J
authors.initials: IJ
authors.lastname: Krauss
authors.forename: Bing
authors.initials: B
authors.lastname: Xu
mesh_terms: D000469:Alkaline Phosphatase / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000138:chemical synthesis* / Q000737:chemistry; D049329:Nanostructures / Q000737:chemistry*; D017239:Paclitaxel / Q000737:chemistry*; D050257:Tubulin Modulators / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D050257:Tubulin Modulators; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D000469:Alkaline Phosphatase; D017239:Paclitaxel