title: Hypersensitivity syndrome induced by anticonvulsants: possible cross-reactivity between carbamazepine and lamotrigine.
abstract: A 14-year-old male presents with erythroderma and fever 44 days after carbamazepine intake. Laboratory exams show eosinophilia and elevated liver enzymes, and thoracic imaging reveals interstitial pneumonitis. All symptoms disappear after carbamazepine withdrawal. A patch test to carbamazepine performed 6 weeks after recovery is positive. About 8 months later, the patient exhibits the same clinical and biological picture 52 days after lamotrigine intake. Lamotrigine is stopped and all symptoms disappear. A patch test to LMG is positive. This case illustrates a possible cross-reactivity between carbamazepine and lamotrigine, which are aromatic and nonaromatic anticonvulsants, respectively.
authors.affiliation: Laboratoire de Pharmacologie, Faculté de Médecine de Monastir, Rue Avicenne, 5019 Monastir, Tunisia. aouam_k@yahoo.fr
authors.forename: Karim
authors.initials: K
authors.lastname: Aouam
authors.forename: Foued
authors.initials: F
authors.lastname: Ben Romdhane
authors.forename: Chaouki
authors.initials: C
authors.lastname: Loussaief
authors.forename: Randa
authors.initials: R
authors.lastname: Salem
authors.forename: Adnène
authors.initials: A
authors.lastname: Toumi
authors.forename: Hichem
authors.initials: H
authors.lastname: Belhadjali
authors.forename: Amel
authors.initials: A
authors.lastname: Chaabane
authors.forename: Naceur A
authors.initials: NA
authors.lastname: Boughattas
authors.forename: Mohamed
authors.initials: M
authors.lastname: Chakroun
mesh_terms: D000293:Adolescent; D000927:Anticonvulsants / Q000009:adverse effects* / Q000276:immunology; D002220:Carbamazepine / Q000009:adverse effects* / Q000276:immunology; D003429:Cross Reactions; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology; D004342:Drug Hypersensitivity / Q000276:immunology* / Q000473:pathology; D006801:Humans; D000077213:Lamotrigine; D008297:Male; D010328:Patch Tests; D012867:Skin / Q000187:drug effects / Q000473:pathology; D013577:Syndrome; D014227:Triazines / Q000009:adverse effects* / Q000276:immunology
chemical_list: D000927:Anticonvulsants; D014227:Triazines; D002220:Carbamazepine; D000077213:Lamotrigine