title: [Phenotypic characteristic of staphylococci and local immunity during bacterial carriage].
abstract: OBJECTIVE
  To assess prevalence and intensity of antilactoferrin and slgA-protease activity in strains of staphylococci and to study the state of local immunity in resident and transitory bacterial carriers.
  
  
  METHODS
  Strains of Staphylococcus aureus and S. epidermidis isolated from 67 healthy persons, who were tested for staphylococcal carriage with subsequent differentiation of types of carriage according to Chistovitch's method, were studied. Antilactoferrin and slgA-protease activity as well as levels of lactoferrin and slgA in nasal secretions were determined using fluoroimmunoassay.
  
  
  RESULTS
  Higher prevalence as well as intensity of antilactoferrin and slgA-protease activity and combination of these characteristics was determined for strains of S. aureus from resident carriers compared with strains from transitory carriers. Higher levels of lactoferrin and slgA were observed in nasal secretions of resident carriers compared with transitory carriers.
  
  
  CONCLUSIONS
  Studied factors could be the markers of resident type of carriage that should be considered for the development of effective measures for sanation in persons with prolonged bacterial carriage.
authors.forename: O L
authors.initials: OL
authors.lastname: Kartashova
authors.forename: A S
authors.initials: AS
authors.lastname: Norkina
authors.forename: I N
authors.initials: IN
authors.lastname: Chaĭnikova
authors.forename: A I
authors.initials: AI
authors.lastname: Smoliagin
mesh_terms: D001426:Bacterial Proteins / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism; D002353:Carrier State / Q000276:immunology*; D006801:Humans; D007781:Lactoferrin / Q000032:analysis / Q000037:antagonists & inhibitors*; D009297:Nasal Mucosa / Q000276:immunology / Q000382:microbiology; D010447:Peptide Hydrolases / Q000032:analysis / Q000378:metabolism; D013203:Staphylococcal Infections / Q000276:immunology* / Q000382:microbiology; D013211:Staphylococcus aureus / Q000472:pathogenicity*; D013212:Staphylococcus epidermidis / Q000472:pathogenicity*
chemical_list: D001426:Bacterial Proteins; D015415:Biomarkers; C070683:surface layer protein A, Bacteria; D010447:Peptide Hydrolases; D007781:Lactoferrin