title: Central nervous system Aspergillus infection after epidural analgesia: diagnosis, therapeutic challenges, and literature review.
abstract: Aspergillus terreus was identified in an intradural spinal biopsy specimen from an African female with recurrent headache and hydrocephalus. Prior laboratory testing of cerebrospinal fluid was nondiagnostic, despite extensive central nervous system (CNS) involvement. CNS Aspergillus infection presents a diagnostic and therapeutic challenge and is reviewed in the context of this particularly instructive and difficult case.
authors.affiliation: Department of Laboratory Medicine, Yale University School of Medicine, P.O. Box 208035, New Haven, CT 06520-8035, USA. jrg9010@med.cornell.edu
authors.forename: Jonathan R
authors.initials: JR
authors.lastname: Genzen
authors.forename: Barton
authors.initials: B
authors.lastname: Kenney
mesh_terms: D000328:Adult; D015360:Analgesia, Epidural / Q000009:adverse effects*; D000935:Antifungal Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000175:diagnosis* / Q000188:drug therapy* / Q000382:microbiology; D001230:Aspergillus / Q000302:isolation & purification*; D002494:Central Nervous System Infections / Q000175:diagnosis* / Q000188:drug therapy* / Q000382:microbiology; D005260:Female; D006801:Humans; D011743:Pyrimidines / Q000627:therapeutic use; D014230:Triazoles / Q000627:therapeutic use; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole