The TCL1 mouse as a model for chronic lymphocytic leukemia.
The TCL1 mouse has been proposed as a mouse model for chronic lymphocytic leukemia. This review details how it resembles the aggressive form of the disease rather than the more common indolent form. Although fulfilled predictions in the human disease based on investigations in the mouse model are at present lacking, there are remarkable similarities between human and mouse leukemias that have led to interesting observations on the pathophysiology of chronic lymphocytic leukemia and have identified putative therapeutic targets.
Hamblin
Terry J
TJ
Cancer Sciences Division, University of Southampton, Southampton General Hospital, Southhampton, UK. terjoha@aol.com
D000818:Animals; D004195:Disease Models, Animal; D016503:Drug Delivery Systems; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000473:pathology*; D051379:Mice; D008822:Mice, Transgenic; D010641:Phenotype; D011518:Proto-Oncogene Proteins / Q000235:genetics
D011518:Proto-Oncogene Proteins; C490393:Tcl1 protein, mouse