title: [Necrobiotic xanthogranuloma: efficacy of surgery in 2 patients].
abstract: Necrobiotic xanthogranuloma is a rare disease characterized by indurated nodules and yellowish-red plaques in the dermis or subdermal tissues particularly in the periorbital region; the lesions are often ulcerated. This disease is frequently associated with hematological disorders such as monoclonal gammopathy and lymphoproliferative disorders. Its pathogenesis is unknown and the small number of cases makes long-term studies difficult. We present 2 cases of periorbital lesions in which the biopsies established a diagnosis of necrobiotic xanthogranuloma. Both patients were treated with corticosteroids and cyclophosphamide, with no improvement. The lesions were excised and the periorbital regions were reconstructed with skin grafts. After 1 year of follow-up there are no signs of recurrence.
authors.affiliation: Servicio de Cirugía Plástica, Hospitales Universitarios Virgen del Rocío, Sevilla, Spain. purigacto@gmail.com
authors.forename: P
authors.initials: P
authors.lastname: Gacto
authors.forename: F
authors.initials: F
authors.lastname: Barrera
authors.forename: J J
authors.initials: JJ
authors.lastname: Pereyra
authors.forename: P
authors.initials: P
authors.lastname: Fernández-Ortega
mesh_terms: D005141:Eyelid Diseases / Q000473:pathology* / Q000601:surgery*; D005260:Female; D006099:Granuloma / Q000473:pathology* / Q000601:surgery*; D015616:Histiocytosis, Non-Langerhans-Cell / Q000473:pathology* / Q000601:surgery*; D006801:Humans; D008875:Middle Aged; D016896:Treatment Outcome