A NEAT way of regulating nuclear export of mRNAs.
In this issue of Molecular Cell, Chen and Carmichael (2009) demonstrate that the noncoding RNA NEAT1 regulates gene expression by restricting nuclear export.
Scadden
Deirdre
D
Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK. adjs100@hermes.cam.ac.uk
D020413:3' Untranslated Regions; D021581:Active Transport, Cell Nucleus; D000243:Adenosine Deaminase / Q000378:metabolism; D020087:Alu Elements; D002454:Cell Differentiation / Q000235:genetics; D002467:Cell Nucleus / Q000378:metabolism*; D022003:Cell Nucleus Structures / Q000378:metabolism; D004268:DNA-Binding Proteins; D053595:Embryonic Stem Cells / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D034521:Nuclear Matrix-Associated Proteins / Q000378:metabolism; D009687:Nuclear Proteins / Q000378:metabolism; D050810:Octamer Transcription Factors / Q000378:metabolism; D000072670:PTB-Associated Splicing Factor; D017393:RNA Editing; D012333:RNA, Messenger / Q000378:metabolism*; D015138:RNA, Nuclear / Q000378:metabolism*; D022661:RNA, Untranslated / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000378:metabolism
D020413:3' Untranslated Regions; D004268:DNA-Binding Proteins; C083214:NONO protein, human; D034521:Nuclear Matrix-Associated Proteins; D009687:Nuclear Proteins; D050810:Octamer Transcription Factors; C450059:PSPC1 protein, human; D000072670:PTB-Associated Splicing Factor; D012333:RNA, Messenger; D015138:RNA, Nuclear; D022661:RNA, Untranslated; D016601:RNA-Binding Proteins; C567955:ADARB1 protein, human; D000243:Adenosine Deaminase