title: GPVI: the inside story.
abstract: The search is on for natural regulators of platelet reactivity. In this issue of Blood, Trifiro and colleagues confirm that the low frequency isoform of platelet GPVI (VIb) attenuates ligand-mediated signal transduction and dampens down platelet reactivity with collagen while not affecting GPVI receptor copy number.
authors.affiliation: French Reference Center for Platelet Disorders.
authors.forename: Alan
authors.initials: A
authors.lastname: Nurden