title: Highly selective and sensitive heparin probing from supramolecular assembly of pyrene derivatives.
abstract: A new quinine derivative PQ, bearing pyrenyl as a fluorophore, was prepared to recognize heparin in aqueous solution. PQ exhibits good selectivity and sensitivity for heparin over other biological molecules. Upon binding with heparin, PQ shows a typical excimer emission peaked at 489 nm along with a weak monomer emission at 376 nm. Moreover, PQ also shows good performance to detect the heparin in serum.
authors.affiliation: Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.
authors.forename: Lintao
authors.initials: L
authors.lastname: Zeng
authors.forename: Pengfei
authors.initials: P
authors.lastname: Wang
authors.forename: Hongyan
authors.initials: H
authors.lastname: Zhang
authors.forename: Xiaoqing
authors.initials: X
authors.lastname: Zhuang
authors.forename: Qing
authors.initials: Q
authors.lastname: Dai
authors.forename: Weimin
authors.initials: W
authors.lastname: Liu
mesh_terms: D005456:Fluorescent Dyes / Q000737:chemistry*; D046911:Macromolecular Substances / Q000138:chemical synthesis / Q000737:chemistry; D008968:Molecular Conformation; D011721:Pyrenes / Q000138:chemical synthesis* / Q000737:chemistry; D011803:Quinine / Q000031:analogs & derivatives / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D005456:Fluorescent Dyes; D046911:Macromolecular Substances; D011721:Pyrenes; D011803:Quinine