Clozapine: acquittal of the usual suspect.
This report concerns the case of a 29-year-old male patient suffering from severe psychotic illness who had been satisfactorily treated with clozapine for 4 months. Clozapine had also been successfully administered during a psychotic episode 5 years previously. Though symptoms of psychosis were successfully controlled following the most recent psychotic episode, a medical consultation assessed that exacerbation of pancreatitis warranted discontinuation of the current antipsychotic treatment regime. Following a series of unsuccessful courses of neuroleptic medication, a magnetic resonance cholangiopancreaticography (MRCP) revealed marked cholecystolithiasis suggesting a biliary pancreatitis. Clozapine treatment was readministered following cholecystectomy. After 4 weeks of antipsychotic treatment the patient was discharged from hospital on clozapine monotherapy.
Schmitz-Hübsch
Tanja
T
Department of Neurology, University of Bonn, Germany.
Schlaepfer
Thomas E
TE
Westheide
Jens
J
von Falkenhausen
Marcus
M
Cooper-Mahkorn
Deirdre
D
Maier
Wolfgang
W
Kühn
Kai-Uwe
KU
D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D049448:Cholangiopancreatography, Magnetic Resonance; D002763:Cholecystectomy; D041761:Cholecystolithiasis / Q000601:surgery; D003024:Clozapine / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D010195:Pancreatitis / Q000473:pathology / Q000601:surgery; D011618:Psychotic Disorders / Q000188:drug therapy*; D028761:Withholding Treatment
D014150:Antipsychotic Agents; D003024:Clozapine