Cytotoxicity of nanostructured vanadium oxide on human cells in vitro.
Vanadium oxide nanostructures have potential uses for electrochemistry and catalysis, yet little is known about their toxicology. In this study, cultured human colon carcinoma cells (Caco-2) were exposed to vanadium oxide and their viability assessed with the neutral red assay. Cells exposed to either vanadium oxide (powdered form) or ethylene diamine intercalated vanadium oxide (enH(2))V(7)O(16) demonstrated no significant reduction in viability after twenty-four hours, yet cells exposed to vanadium oxide nanotubes demonstrated a significant loss in viability after four hours. The physical size and structure of the nanotubes may play an important role in their cytotoxic effects, and the safety of using such nanomaterials must be considered.
Rhoads
Laura S
LS
Department of Biology, State University of New York, Potsdam, NY 13676, USA. rhoadsls@potsdam.edu
Silkworth
William T
WT
Roppolo
Megan L
ML
Whittingham
M Stanley
MS
D000588:Amines / Q000737:chemistry; D018938:Caco-2 Cells; D002470:Cell Survival / Q000187:drug effects; D004847:Epithelial Cells / Q000187:drug effects / Q000648:ultrastructure; D005029:Ethylenediamines / Q000737:chemistry*; D006801:Humans; D053758:Nanoparticles / Q000633:toxicity*; D043942:Nanotubes; D009499:Neutral Red; D010087:Oxides / Q000737:chemistry; D013501:Surface-Active Agents / Q000737:chemistry; D013535:Suspensions; D017968:Vanadium Compounds / Q000737:chemistry* / Q000633:toxicity; D014961:X-Ray Diffraction
D000588:Amines; D005029:Ethylenediamines; D010087:Oxides; D013501:Surface-Active Agents; D013535:Suspensions; D017968:Vanadium Compounds; D009499:Neutral Red; C031234:ethylenediamine; C066075:vanadium pentoxide; C003935:dodecylamine