title: Pyrodysinoic acid derivatives from the marine sponge Dysidea robusta.
abstract: Three new nitrogen-containing terpenes related to pyrodysinoic acid (1) have been isolated from the sponge Dysidea robusta collected in Brazil. Isopyrodysinoic acid (2), 13-hydroxyisopyrodysinoic acid (3), and pyrodysinoic acid B (4) were obtained from the crude extract of D. robusta and identified by analysis of spectroscopic data. Pyrodysinoic acid B (4) is the first furodysin or furodysinin sesquiterpene derivative with a trans junction between the two six-membered rings of the 1,2,3,4,4a,7,8,8a-octahydro-1,1,6-trimethylnaphthalene moiety.
authors.affiliation: Instituto de Química de São Carlos, Universidade de São Paulo, São Carlos, SP, Brazil.
authors.forename: David E
authors.initials: DE
authors.lastname: Williams
authors.forename: Suzi O
authors.initials: SO
authors.lastname: Marques
authors.forename: Eduardo
authors.initials: E
authors.lastname: Hajdu
authors.forename: Solange
authors.initials: S
authors.lastname: Peixinho
authors.forename: Raymond J
authors.initials: RJ
authors.lastname: Andersen
authors.forename: Roberto G S
authors.initials: RG
authors.lastname: Berlinck
mesh_terms: D000818:Animals; D001938:Brazil; D047088:Dysidea / Q000737:chemistry*; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D012717:Sesquiterpenes; C442627:pyrodysinoic acid