title: Role of matrix metalloproteinases in coronary artery disease.
abstract: OBJECTIVE
  Matrix metalloproteinases (MMPs) contribute both in the formation as well as in the destabilization of atherosclerotic plaque. In the present study we analyzed circulating levels of MMP-7 that acts on chondroitin sulphate a proteoglycan that is particularly abundant in atherosclerotic plaque and MMP-8 which acts on Type I collagen, the synthesis and degradation of which is important for stability of the plaque and correlate with the degree of severity of coronary artery disease (CAD).
  
  
  METHODS
  Circulating levels of MMP-7 and MMP-8 and tissue inhibitors of MMP (TIMP) -1 and TIMP-2 were analysed by Enzyme Linked ImmunoSorbent Assay (ELISA7rpar;, in patients with acute myocardial infarction (AMI) at presentation (N=48), acute coronary syndrome (ACS) group (N=227rpar; (on treatment) and stable angina group (N=17) (on treatment).
  
  
  RESULTS
  There was significant rise in MMP-8 (88.23%, P=0.001), in AMI group which decreased in ACS treated group 7lpar;15.9%, non-significant) as compared to controls. There was increasing trend of MMP-7 in AMI and ACS group and strong correlation with hsCRP. MMP-7 predominated in stable angina group. There was significant decrease in TIMP-2 in AMI group and TIMP-1 and TIMP-2 in ACS and stable angina group as compared to controls.
  
  
  CONCLUSIONS
  Significant increase in MMP-8 and decrease in TIMP-2 during acute stage of AMI suggests MMP-8 and TIMP-2 are markers for vulnerable plaque independent of hsCRP for AMI. MMP-7 was found to be elevated in stable angina patients and was correlated with hsCRP at acute phase of AMI suggesting persistent at all stages of CAD.
authors.affiliation: Sir H. N. Hospital and Research Centre, Raja Rammohan Roy Road, Mumbai, India.
authors.forename: Vinod K
authors.initials: VK
authors.lastname: Shah
authors.forename: Kavita K
authors.initials: KK
authors.lastname: Shalia
authors.forename: Manoj R
authors.initials: MR
authors.lastname: Mashru
authors.forename: Surendra L
authors.initials: SL
authors.lastname: Soneji
authors.forename: Ajin
authors.initials: A
authors.lastname: Abraham
authors.forename: Ketki V
authors.initials: KV
authors.lastname: Kudalkar
authors.forename: Jagdish B
authors.initials: JB
authors.lastname: Vasvani
authors.forename: Snehal T
authors.initials: ST
authors.lastname: Sanghavi
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000201:enzymology*; D005260:Female; D006801:Humans; D008297:Male; D020782:Matrix Metalloproteinases; D008875:Middle Aged
chemical_list: D020782:Matrix Metalloproteinases