Genomewide screens in ankylosing spondylitis.
Efforts to identify genes other than HLA-B27 in AS have been driven by the strength of the evidence from genetic epidemiology studies indicating that HLA-B27, although a major gene in AS, is dearly not the only significant gene operating. This is the case for both genetic determinants of disease-susceptibility and phenotypic characteristics such as disease severity and associated disease features. In this chapter the genetic epidemiology of AS and the gene-mapping studies performed to date will be reviewed and the future direction of research in this field discussed.
Brown
Matthew A
MA
Diamantina Institute of Cancer, Immunology and Metabolic Medicine, Princess Alexandra Hospital, Woolloongabba, Qld, Australia. matt.brown@uq.edu.au
D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D015796:HLA-B27 Antigen / Q000235:genetics / Q000276:immunology; D008285:Major Histocompatibility Complex / Q000235:genetics; D013167:Spondylitis, Ankylosing / Q000235:genetics / Q000276:immunology
D015796:HLA-B27 Antigen