Long-term follow-up of the treatment of renal angiomyolipomas after selective arterial embolization with alcohol.
METHODS
Therapy (case series).


METHODS
4.


OBJECTIVE
To present our institution's experience of selective embolization of renal angiomyolipomas with alcohol and the long-term follow up data.


METHODS
This retrospective study included 34 patients treated between October 1997 and October 2007 (29 women and five men, mean age 44 years). Of these patients, nine had tuberous sclerosis, 14 were bilateral and 16 were multifocal. Indications for treatment were previous haemorrhage (14), size >4 cm (19) and increasing size over a short period (one). The largest treated lesion was 24.4 cm, and the mean (range) size was 11.9 (2.9-24.4) cm. All patients were treated by selective embolization using a mixture of alcohol and lipiodol. Three patients also had coiling of aneurysms and two patients had additional embolization with polyvinyl alcohol particles. The follow-up was both radiological and clinical, with recurrence defined as growth by >2 cm or symptoms requiring further treatment.


RESULTS
The technical success rate was 100%, with only one significant complication of non-target renal embolization, with self-limiting effects. Minor complications included 11 patients with post-embolization syndrome, all of which settled with conservative measures. The mean (range) combined radiological and clinical follow-up was 44.2 (12-116) months, with all patients having a follow-up of >1 year. Radiological success was achieved in 97%, with only one lesion growing by >2 cm. The combined clinical and radiological success rate was 85%, with two patients undergoing surgery, two having repeat embolization and one currently offered surgery due to a recent increase in size.


CONCLUSIONS
Our study provides long-term evidence that selective arterial embolization with alcohol is a safe and effective method for improving clinical symptoms (85%) and preventing tumour progression (97%) in patients with renal angiomyolipoma.
Chick
Christopher M
CM
Department of Diagnostic Radiology, Singapore General Hospital, Singapore.
Tan
Bien-Soo
BS
Cheng
Christopher
C
Taneja
Manish
M
Lo
Richard
R
Tan
Yeh-Hong
YH
Lin
Shueh-En
SE
Tay
Kiang-Hiong
KH
D000328:Adult; D000368:Aged; D018207:Angiomyolipoma / Q000000981:diagnostic imaging / Q000628:therapy*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D016461:Chemoembolization, Therapeutic / Q000379:methods*; D018450:Disease Progression; D000431:Ethanol / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007459:Iodized Oil / Q000008:administration & dosage*; D007680:Kidney Neoplasms / Q000000981:diagnostic imaging / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000209:etiology; D015641:Radiography, Interventional; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult
D000431:Ethanol; D007459:Iodized Oil