title: A new anthraquinone from Morinda citrifolia roots.
abstract: An investigation of Morinda citrifolia roots afforded a new anthraquinone, 2-ethoxy-1-hydroxyanthraquinone (1), along with five other known anthraquinones: 1-hydroxy-2-methylanthraquinone (2), damnacanthal (3), nordamnacanthal (4), 2-formyl-1-hydroxyanthraquinone (5) and morindone-6-methyl-ether (6). This is the first report on the isolation of morindone-6-methyl-ether (6) from this plant. The structures of these compounds were elucidated based on spectroscopic analyses such as NMR, MS and IR. Biological evaluation of five pure compounds and all the extracts against the larvae of Aedes aegypti indicated 1-hydroxy-2-methylanthraquinone (2) and damnacanthal (3) were the extracts to exhibit promising larvicidal activities.
authors.affiliation: Department of Chemistry, Faculty of Science, University Putra Malaysia, 43400 Serdang, Selangor, Malaysia. gwen@fsas.upm.edu.my
authors.forename: G C L
authors.initials: GC
authors.lastname: Ee
authors.forename: Y P
authors.initials: YP
authors.lastname: Wen
authors.forename: M A
authors.initials: MA
authors.lastname: Sukari
authors.forename: R
authors.initials: R
authors.lastname: Go
authors.forename: H L
authors.initials: HL
authors.lastname: Lee
mesh_terms: D000330:Aedes / Q000187:drug effects; D000447:Aldehydes / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000880:Anthraquinones / Q000737:chemistry* / Q000494:pharmacology; D007306:Insecticides / Q000737:chemistry / Q000494:pharmacology; D007814:Larva / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D032066:Morinda / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D000880:Anthraquinones; D007306:Insecticides; C465644:nordamnacanthal; C079170:damnacanthal; C061208:1-hydroxyanthraquinone