Genetic lesions in chronic lymphocytic leukemia: clinical implications.
OBJECTIVE
To analyze recent scientific contributions correlating genetic lesions with clinical features in chronic lymphocytic leukemia (CLL).


RESULTS
Genetic abnormalities are increasingly important to understand not only CLL biology but also other aspects such as its epidemiology, diagnosis, prognosis, and clinical evolution.


CONCLUSIONS
Genetic abnormalities provide important clues in understanding the clinical and biologic heterogeneity of CLL, assessing the individual risk of each patient with this form of leukemia and also predicting response to therapy.
Montserrat
Emili
E
Institute of Hematology and Oncology, Department of Hematology, Hospital Clinic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Villarroel, Barcelona, Spain. emontse@clinic.ub.es
Moreno
Carol
C
D020869:Gene Expression Profiling; D015973:Gene Expression Regulation, Leukemic; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D017404:In Situ Hybridization, Fluorescence; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000175:diagnosis* / Q000235:genetics* / Q000628:therapy; D035683:MicroRNAs / Q000235:genetics; D011379:Prognosis; D016896:Treatment Outcome; D051746:ZAP-70 Protein-Tyrosine Kinase / Q000235:genetics
D007143:Immunoglobulin Heavy Chains; D035683:MicroRNAs; D051746:ZAP-70 Protein-Tyrosine Kinase