title: A conjunctival lesion with histological features similar to large-cell acanthoma of the skin.
abstract: Large-cell acanthoma (LCA) is a sharply demarcated epidermal lesion composed of large keratinocytes and characterized by hyperkeratosis, hypergranulosis and orthokeratosis. It usually affects actinically damaged skin. LCA is currently believed to be a distinct entity with an unclear pathogenesis and a benign biologic behavior. Here, we describe the first occurrence of LCA in the conjunctiva. The lesion recurred following initial excision, and later recurred as a carcinoma in situ following a second excision. This case suggests that LCA may have a malignant and transformation potential.
authors.affiliation: Department of Ophthalmology The University of Virginia Health System, Charlottesville, Virginia, USA. ngg6f@virginia.edu
authors.forename: Nicola G
authors.initials: NG
authors.lastname: Ghazi
authors.forename: Bina S
authors.initials: BS
authors.lastname: Patel
authors.forename: Leslie A
authors.initials: LA
authors.lastname: Olsakovsky
authors.forename: Kevin
authors.initials: K
authors.lastname: White
authors.forename: James W
authors.initials: JW
authors.lastname: Patterson
authors.forename: Bruce
authors.initials: B
authors.lastname: Carter
mesh_terms: D049309:Acanthoma / Q000473:pathology*; D003230:Conjunctival Neoplasms / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology*