title: Mesomelic dysplasia with acral synostoses Verloes-David-Pfeiffer type: follow-up study documents progressive clinical course.
abstract: Verloes-David-Pfeiffer mesomelia-synostoses syndrome is an autosomal-dominant form of mesomelic dysplasia comprising typical acral synostoses combined with ptosis, hypertelorism, palatal abnormality, CHD, and ureteral anomalies. Since the original reports in 1995, two other patients have been described with this syndrome, one of them the patient reported in 1998 by Day-Salvatore. In this article, we report on the follow-up of some of the original cases and review the literature. We confirm that the Verloes-David-Pfeiffer syndrome (VDPS) is a progressive skeletal disorder that despite repeated corrective surgical intervention leads to severe limb deformities. No mutations were detected in the FLNB gene. To date, the cause and the pathogenesis of VDPS remain unknown. The latter is characterized in this study as a syndromic type of skeletal dysplasia because besides congenital malformations and multiple acromelic synostoses arising prenatally, VDPS manifests in postnatal life as a severe osteochondrodysplasia.
authors.affiliation: Service de Génétique Médicale, Centre Hospitalo-Universitaire, Nantes, France. bertrand.isidor@chu-nantes.fr
authors.forename: Bertrand
authors.initials: B
authors.lastname: Isidor
authors.forename: Antoine
authors.initials: A
authors.lastname: Hamel
authors.forename: Frank
authors.initials: F
authors.lastname: Plasschaert
authors.forename: Lieve
authors.initials: L
authors.lastname: Claus
authors.forename: Jacques-Marie
authors.initials: JM
authors.lastname: Mercier
authors.forename: Geert R
authors.initials: GR
authors.lastname: Mortier
authors.forename: Jules G
authors.initials: JG
authors.lastname: Leroy
authors.forename: Alain
authors.initials: A
authors.lastname: Verloes
authors.forename: Albert
authors.initials: A
authors.lastname: David
mesh_terms: D000015:Abnormalities, Multiple / Q000145:classification / Q000175:diagnosis*; D000168:Acrocephalosyndactylia / Q000150:complications / Q000175:diagnosis*; D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D013577:Syndrome; D013580:Synostosis / Q000150:complications*