Inhibitors of osteoclast formation from rhizomes of Cibotium barometz.
Eight compounds (1-8) were isolated from a methanol extract of Cibotium barometz rhizomes including two new furan derivatives, cibotiumbarosides A (1) and B (2), and a new glycoglycerolipid, cibotiglycerol (4). Their structures were elucidated by chemical and spectroscopic methods. Compounds 2-5 each showed inhibition of osteoclast formation with no affect on BMM cell viability.
Cuong
Nguyen Xuan
NX
Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi, Vietnam.
Minh
Chau Van
CV
Kiem
Phan Van
PV
Huong
Hoang Thanh
HT
Ban
Ninh Khac
NK
Nhiem
Nguyen Xuan
NX
Tung
Nguyen Huu
NH
Jung
Ji-Won
JW
Kim
Hyun-Ju
HJ
Kim
Shin-Yoon
SY
Kim
Jeong Ah
JA
Kim
Young Ho
YH
D000818:Animals; D029624:Ferns / Q000737:chemistry*; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006017:Glycolipids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010010:Osteoclasts / Q000187:drug effects*; D027343:Rhizome / Q000737:chemistry; D014744:Vietnam
D005663:Furans; D006017:Glycolipids; D006027:Glycosides; C544365:cibotiglycerol; C544363:cibotiumbaroside A; C544364:cibotiumbaroside B; C015903:glycerolglycolipids