title: Antiproliferative triterpenoid saponins of Dodonaea viscosa from the Madagascar dry forest.
abstract: Bioassay-guided fractionation of an EtOH extract obtained from the roots of the Madagascan plant Dodonaea viscosa led to the isolation of two new antiproliferative oleanane-type triterpenoid saponins, dodoneasides A and B (1 and 2). The structures of these two new compounds were elucidated using 1D and 2D NMR experiments and mass spectrometry. Compounds 1 and 2 showed antiproliferative activity against the A2780 human ovarian cancer cell line with IC(50) values of 0.79 and 0.70 muM, respectively.
authors.affiliation: Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.
authors.forename: Shugeng
authors.initials: S
authors.lastname: Cao
authors.forename: Peggy
authors.initials: P
authors.lastname: Brodie
authors.forename: Martin
authors.initials: M
authors.lastname: Callmander
authors.forename: Richard
authors.initials: R
authors.lastname: Randrianaivo
authors.forename: Jeremi
authors.initials: J
authors.lastname: Razafitsalama
authors.forename: Etienne
authors.initials: E
authors.lastname: Rakotobe
authors.forename: Vincent E
authors.initials: VE
authors.lastname: Rasamison
authors.forename: Karen
authors.initials: K
authors.lastname: TenDyke
authors.forename: Yongchun
authors.initials: Y
authors.lastname: Shen
authors.forename: Edward M
authors.initials: EM
authors.lastname: Suh
authors.forename: David G I
authors.initials: DG
authors.lastname: Kingston
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D008270:Madagascar; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D029631:Sapindaceae / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D012503:Saponins; D014315:Triterpenes; C544250:dodoneaside A; C544251:dodoneaside B