Targeted venous occlusion using pulsed high-intensity focused ultrasound.
Targeted vascular occlusion is desirable for clinical therapies such as in the treatment of esophageal and gastric varices and varicose veins. The feasibility of ultrasound-mediated endothelial damage for vascular occlusion was studied. A segment of a rabbit auricular vein was treated in vivo with low duty cycle, high peak rarefaction pressure (9 MPa) high-intensity focused ultrasound pulses in the presence of intravenously administered circulating microbubbles, followed by fibrinogen injection, which resulted in the formation of an acute occlusive intravascular thrombus. Further investigation and refinements of treatment protocols are necessary for producing durable vascular occlusion.
Hwang
Joo Ha
JH
Division of Gastroenterology, Department ofMedicine, Center for Industrial and Medical Ultrasound, Applied PhysicsLaboratory, University of Washington, Seattle, WA 98195, USA. jooha@medicine.washington.edu
Zhou
Yufeng
Y
Warren
Cinderella
C
Brayman
Andrew A
AA
Crum
Lawrence A
LA
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects; D003287:Contrast Media / Q000008:administration & dosage; D004423:Ear / Q000098:blood supply; D004730:Endothelium, Vascular / Q000187:drug effects / Q000293:injuries; D005340:Fibrinogen / Q000008:administration & dosage; D057086:High-Intensity Focused Ultrasound Ablation / Q000379:methods*; D006651:Histocytochemistry; D011817:Rabbits; D013927:Thrombosis / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000209:etiology*; D014463:Ultrasonography
D003287:Contrast Media; D005340:Fibrinogen