title: Role of the ghrelin/obestatin balance in the regulation of neuroendocrine circuits controlling body composition and energy homeostasis.
abstract: Ghrelin and obestatin are two peptides isolated from the gastrointestinal tract and encoded by the same preproghrelin gene. They convey to the central nervous system informations concerning the nutritional status and/or the energy stores. Ghrelin, mostly acting through the GH secretagogue receptor GHS-R, is a potent GH secretagogue, an orexigenic peptide and a long-term regulator of energy homeostasis. Obestatin was initially described for its anorexigenic effects and its binding to the G protein-coupled receptor 39 (GPR39). However, the role of obestatin is still controversial and the nature of the obestatin receptor remains an open question. This review is focussed on the possible implication of the ghrelin/obestatin system in psychiatric diseases with particular emphasis on eating disorders.
authors.affiliation: Centre de Psychiatrie & Neurosciences, UMR 894 Inserm, Faculté de Médecine, Université Paris Descartes, Paris, France. jacques.epelbaum@inserm.fr
authors.forename: Jacques
authors.initials: J
authors.lastname: Epelbaum
authors.forename: Nawel
authors.initials: N
authors.lastname: Bedjaoui
authors.forename: Roland
authors.initials: R
authors.lastname: Dardennes
authors.forename: Dan Dan
authors.initials: DD
authors.lastname: Feng
authors.forename: Robert
authors.initials: R
authors.lastname: Gardette
authors.forename: Dominique
authors.initials: D
authors.lastname: Grouselle
authors.forename: Catherine
authors.initials: C
authors.lastname: Loudes
authors.forename: Axelle
authors.initials: A
authors.lastname: Simon
authors.forename: Virginie
authors.initials: V
authors.lastname: Tolle
authors.forename: Seung Kwon
authors.initials: SK
authors.lastname: Yang
authors.forename: Philippe
authors.initials: P
authors.lastname: Zizzari
mesh_terms: D000818:Animals; D001823:Body Composition / Q000502:physiology*; D004734:Energy Metabolism / Q000502:physiology*; D025461:Feedback, Physiological / Q000502:physiology; D054439:Ghrelin / Q000378:metabolism*; D006801:Humans; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism; D054440:Receptors, Ghrelin / Q000378:metabolism
chemical_list: C495797:GPR39 protein, human; D054439:Ghrelin; D043562:Receptors, G-Protein-Coupled; D054440:Receptors, Ghrelin