title: ANCA-associated vasculitis following influenza vaccination: causal association or mere coincidence?
abstract: Whether autoimmune or rheumatic disease may be precipitated after vaccination is controversially discussed among experts. Here we describe 4 cases of new onset or relapsing antineutrophil cytoplasmic antibodies associated vasculitis occurring in timely association with influenza vaccination. In the literature different subtypes of vasculitis have been repeatedly reported after influenza vaccination. Several trials in patients with preexisting auto-immune disease failed to indicate an increased risk for disease recurrence after influenza vaccination but these investigations might be underpowered to detect this very rare but relevant side effect. Although our report does not prove a causal association between vaccination and vasculitis, it seems possible that in rare cases vaccination might induce vasculitic disease.
authors.affiliation: Fifth Department of Medicine, University Hospital Mannheim, Germany. rainer.birck@med5.ma.uni-heidelberg.de
authors.forename: Rainer
authors.initials: R
authors.lastname: Birck
authors.forename: Isabelle
authors.initials: I
authors.lastname: Kaelsch
authors.forename: Peter
authors.initials: P
authors.lastname: Schnuelle
authors.forename: Luis Felipe
authors.initials: LF
authors.lastname: Flores-Suárez
authors.forename: Rainer
authors.initials: R
authors.lastname: Nowack
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D056648:Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology*; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood; D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007252:Influenza Vaccines / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009173:Mycophenolic Acid / Q000031:analogs & derivatives / Q000627:therapeutic use; D012307:Risk Factors
chemical_list: D000305:Adrenal Cortex Hormones; D019268:Antibodies, Antineutrophil Cytoplasmic; D007166:Immunosuppressive Agents; D007252:Influenza Vaccines; D003520:Cyclophosphamide; D009173:Mycophenolic Acid