title: [Correlation of multi-slice spiral CT features to clinicopathologic manifestations of gastrointestinal stromal tumor: a report of 49 cases].
abstract: OBJECTIVE
  Gastrointestinal stromal tumor (GIST) is one of the most common mesenchymal tumors of the digestive system. Imaging examination plays an important role in preoperative diagnosis and postoperative evaluation for it. This study was to describe the multi-slice spiral computed tomographic (MSCT) findings and pathologic features of GIST, and to analyze their correlation.
  
  
  METHODS
  MSCT and pathologic reports of 49 patients with 53 pathologically confirmed GIST lesions were reviewed and compared.
  
  
  RESULTS
  Of the 53 GIST lesions, 14 were at very low biological risk, 11 at low risk, ten at moderate risk and 18 at high risk; 36 (67.9%) were found in first visit by CT scans. On CT images, the GIST lesions with maximal diameter of > or =50 mm showed irregular shape, invasive growth, presence of cystic area and heterogeneous enhancement, and most of them were at high risk; the lesions with maximal diameter of <50 mm showed regular shape, expansive growth, and homogeneous enhancement, and most of them were at risk of moderate or below. No lymph node metastasis was found. Only three lesions showed S100-positive, which presented infiltration along the gastric wall or bowel ring on CT images.
  
  
  CONCLUSIONS
  CT examination is helpful in risk prediction for GIST, but it is difficult to detect small lesions (< 2 cm) by CT scans. Due to the infiltrative growth of GIST with neural differentiation (S100-positive), it is difficult to distinguish GIST from gastric cancer on CT images.
authors.affiliation: State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, 510060, PR China.
authors.forename: Shao-Han
authors.initials: SH
authors.lastname: Yin
authors.forename: Chuan-Miao
authors.initials: CM
authors.lastname: Xie
authors.forename: Yun-Xian
authors.initials: YX
authors.lastname: Mo
authors.forename: Zi-Lin
authors.initials: ZL
authors.lastname: Huang
authors.forename: Yan-Chun
authors.initials: YC
authors.lastname: Lu
authors.forename: Xue-Wen
authors.initials: XW
authors.lastname: Liu
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhang
authors.forename: Jian-Peng
authors.initials: JP
authors.lastname: Li
authors.forename: Lie
authors.initials: L
authors.lastname: Zheng
authors.forename: Pei-Hong
authors.initials: PH
authors.lastname: Wu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003937:Diagnosis, Differential; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000175:diagnosis; D046152:Gastrointestinal Stromal Tumors / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007889:Leiomyoma / Q000175:diagnosis; D007890:Leiomyosarcoma / Q000175:diagnosis; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary; D008297:Male; D008875:Middle Aged; D009442:Neurilemmoma / Q000175:diagnosis; D009418:S100 Proteins / Q000378:metabolism; D036542:Tomography, Spiral Computed / Q000379:methods*; D047368:Tumor Burden; D055815:Young Adult
chemical_list: D009418:S100 Proteins