HLA-B27 and host-pathogen interaction.
HLA-B27 is a risk factor closely associated to spondyloarthropathies (SpA). One form of SpA is reactive arthritis (ReA), which develops as a complication after certain bacterial infections (e.g., Salmonellae, Yersiniae, Shigellae, Campylobacteriae and Chlamydiae). The development of infection-triggered complication is a complex train of events between the triggering bacteria and the host. Since most of the patients suffering from ReA are HLA-B27 positive, it has been proposed that HLA-B27 may modulate the interaction between ReA-triggering bacteria and host cell. Besides antigen presenting function, HLA-B27 displays other unusual properties that might be of importance in the development of ReA. These properties (homodimer formation and misfolding of HLA-B27 heavy chain in the endoplasmic reticulum (ER)) may trigger ER-stress signaling pathways in host cell, which in turn may modulate cell signaling in favor of ReA-triggering bacteria. Here we summarize the observations of HLA-B27 modulating the interaction between ReA-triggering bacteria and host cell and discuss potential mechanisms behind the interaction.
Sahlberg
Anna S
AS
Department of Bacterial and Inflammatory Diseases, National Public Health Institute, Turku, Finland.
Granfors
Kaisa
K
Penttinen
Markus A
MA
D000818:Animals; D017951:Antigen Presentation / Q000276:immunology; D001424:Bacterial Infections / Q000276:immunology; D015796:HLA-B27 Antigen / Q000235:genetics / Q000276:immunology*; D054884:Host-Pathogen Interactions; D006801:Humans; D008070:Lipopolysaccharides / Q000276:immunology; D000091402:Prohibitins; D015398:Signal Transduction / Q000276:immunology
D015796:HLA-B27 Antigen; D008070:Lipopolysaccharides; C000717331:PHB2 protein, human; D000091402:Prohibitins