Flavanoids and pterocarpans from the bark of Erythrina fusca.
Three new isomeric flavanones, fuscaflavanones A(1) (1), A(2) (2) and B (3), together with six known flavanones, lupinifolin (4), lonchocarpol A (5), a mixture of lonchocarpols C(1) and C(2) (6a, b), and a mixture of lonchocarpols D(1) and D(2) (7a, b), five pterocarpans, sandwicensin (8), phaseollidin (9), erythrabissin I (10), and a mixture of dolichins A and B (11a, b), one chalcone, isobavachalcone (12), and one isoflavone, wighteone (13), were isolated from the bark of Erythrina fusca LOUR. Their structures were elucidated on the basis of spectroscopic data. Some isolates were tested for antiplasmodial and cytotoxic activities and it was found that 5 and 9 exhibited moderate antiplasmodial activity against Plasmodium falciparum. For cytotoxicity, compounds 1, 4, 5, 9 and 12 showed moderate to weak activity against KB, BC and NCI-H187 cells, whereas 2 exhibited only weak activity against KB cells.
Innok
Phongsak
P
Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Ramkhamhaeng University, Thailand.
Rukachaisirikul
Thitima
T
Suksamrarn
Apichart
A
D000962:Antimalarials / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D004895:Erythrina / Q000737:chemistry*; D047309:Flavones / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity / Q000652:urine; D005419:Flavonoids / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D006801:Humans; D007536:Isomerism; D024301:Plant Bark / Q000737:chemistry; D036343:Pterocarpans / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity
D000962:Antimalarials; D047309:Flavones; D005419:Flavonoids; D036343:Pterocarpans; C545016:fuscaflavanone A1; C545017:fuscaflavanone A2; C545018:fuscaflavanone B