title: Predicting adverse neonatal outcomes in fetuses with abdominal wall defects using prenatal risk factors.
abstract: OBJECTIVE
  The aim of this study was to determine whether prenatal variables can predict adverse neonatal outcomes in fetuses with abdominal wall defects.
  
  
  METHODS
  A retrospective cohort study that used ultrasound and neonatal records for all cases of gastroschisis and omphalocele seen over a 16-year period. Cases with adverse neonatal outcomes were compared with noncases for multiple candidate predictive factors. Univariable and multivariable statistical methods were used to develop the prediction models, and effectiveness was evaluated using the area under the receiver operating characteristic curve.
  
  
  RESULTS
  Of 80 fetuses with gastroschisis, 29 (36%) had the composite adverse outcome, compared with 15 of 33 (47%) live neonates with omphalocele. Intrauterine growth restriction was the only significant variable in gastroschisis, whereas exteriorized liver was the only predictor in omphalocele. The areas under the curve for the prediction models with gastroschisis and omphalocele are 0.67 and 0.74, respectively.
  
  
  CONCLUSIONS
  Intrauterine growth restriction and exteriorization of the liver are significant predictors of adverse neonatal outcome with gastroschisis and omphalocele.
authors.affiliation: Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO, USA.
authors.forename: Sara S
authors.initials: SS
authors.lastname: Nicholas
authors.forename: David M
authors.initials: DM
authors.lastname: Stamilio
authors.forename: Jeffery M
authors.initials: JM
authors.lastname: Dicke
authors.forename: Diana L
authors.initials: DL
authors.lastname: Gray
authors.forename: George A
authors.initials: GA
authors.lastname: Macones
authors.forename: Anthony O
authors.initials: AO
authors.lastname: Odibo
mesh_terms: D000328:Adult; D005260:Female; D005317:Fetal Growth Retardation / Q000453:epidemiology*; D020139:Gastroschisis / Q000453:epidemiology*; D006554:Hernia, Umbilical / Q000453:epidemiology*; D006801:Humans; D008423:Maternal Age; D006831:Polyhydramnios / Q000453:epidemiology; D011247:Pregnancy; D011256:Pregnancy Outcome; D012372:ROC Curve; D012307:Risk Factors; D055815:Young Adult