A decade of molecular pathogenomic analysis of group A Streptococcus.
Molecular pathogenomic analysis of the human bacterial pathogen group A Streptococcus has been conducted for a decade. Much has been learned as a consequence of the confluence of low-cost DNA sequencing, microarray technology, high-throughput proteomics, and enhanced bioinformatics. These technical advances, coupled with the availability of unique bacterial strain collections, have facilitated a systems biology investigative strategy designed to enhance and accelerate our understanding of disease processes. Here, we provide examples of the progress made by exploiting an integrated genome-wide research platform to gain new insight into molecular pathogenesis. The studies have provided many new avenues for basic and translational research.
Musser
James M
JM
Center for Molecular and Translational Human Infectious Diseases Research, The Methodist Hospital Research Institute, Houston, Texas 77030, USA. jmmusser@tmhs.org
Shelburne
Samuel A
SA
D022761:Gene Transfer, Horizontal; D016680:Genome, Bacterial; D055106:Genome-Wide Association Study; D023281:Genomics; D054884:Host-Pathogen Interactions; D006801:Humans; D017720:Molecular Epidemiology; D013290:Streptococcal Infections / Q000453:epidemiology / Q000209:etiology / Q000382:microbiology; D022541:Streptococcal Vaccines / Q000302:isolation & purification; D013297:Streptococcus pyogenes / Q000235:genetics* / Q000472:pathogenicity*; D049490:Systems Biology; D014774:Virulence / Q000235:genetics; D037521:Virulence Factors / Q000096:biosynthesis / Q000235:genetics
D022541:Streptococcal Vaccines; D037521:Virulence Factors