Montmorillonite-alginate nanocomposites as a drug delivery system: intercalation and in vitro release of vitamin B1 and vitamin B6.
Sustained intestinal delivery of thiamine hydrochloride (Vitamin B(1); VB(1)) and pyridoxine hydrochloride (Vitamin B(6); VB(6)) seems to be a feasible alternative to existing therapy. The vitamins (VB(1)/VB(6)) intercalated in montmorillonite (MMT) and intercalated VB(1)/VB(6)-MMT hybrid is further used for synthesis of VB(1)/VB(6)-MMT-alginate nanocomposite beads by gelation method and in vitro release in the intestinal environment. The structure and surface morphology of the synthesized VB(1)/VB(6)-MMT hybrid, VB(1)/VB(6)-alginate and VB(1)/VB(6)-MMT-alginate nanocomposite beads were characterized by XRD, FT-IR, TGA and SEM. In vitro release experiments revealed that the VB(1)/VB(6) releases suddenly from VB(1)/VB(6)-MMT hybrid and is pH dependent. The controlled release of VB(1)/VB(6) from VB(1)/VB(6)-MMT-alginate nanocomposite beads was observed to be controlled as compared to their release from VB(1)/VB(6)-MMT hybrid and VB(1)/VB(6)-alginate beads.
Kevadiya
Bhavesh D
BD
Discipline of Inorganic Materials and Catalysis, Central Salt and Marine Chemicals Research Institute (Council of Scientific & Industrial Research CSIR), Gijubhai Badheka Marg, Bhavnagar 364 002, Gujarat, India.
Joshi
Ghanshyam V
GV
Patel
Hasmukh A
HA
Ingole
Pravin G
PG
Mody
Haresh M
HM
Bajaj
Hari C
HC
D000464:Alginates; D001546:Bentonite; D004337:Drug Carriers; D020723:Glucuronic Acid; D006603:Hexuronic Acids; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D008855:Microscopy, Electron, Scanning; D053761:Nanocomposites; D017550:Spectroscopy, Fourier Transform Infrared; D013818:Thermogravimetry; D013831:Thiamine / Q000008:administration & dosage*; D025101:Vitamin B 6 / Q000008:administration & dosage*; D014961:X-Ray Diffraction
D000464:Alginates; D004337:Drug Carriers; D006603:Hexuronic Acids; D001546:Bentonite; D025101:Vitamin B 6; D020723:Glucuronic Acid; D013831:Thiamine