Effects of collagen and collagen hydrolysate from jellyfish (Rhopilema esculentum) on mice skin photoaging induced by UV irradiation.
Collagen (JC) was extracted from jellyfish (Rhopilema esculentum) and hydrolyzed to prepare collagen hydrolysate (JCH). The protective effects of JC and JCH against UV-induced damages to mice skin were evaluated and compared in this article. JC and JCH could alleviate the UV-induced abnormal changes of antioxidative indicators, including the superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) activities and the contents of glutathione (GSH) and malondiaidehyde (MDA). JC and JCH could protect skin lipid and collagen from the UV radiation damages. Furthermore, the changes of total ceramide and glycosaminoglycan in skin were recovered significantly by JC and JCH. The action mechanisms mainly involved the antioxidative properties and the repairing to endogenous collagen synthesis of JC and JCH in vivo. JCH with the lower molecular weight showed much higher effects than JC. The results indicated that JCH was a novel antiphotoaging agent from natural resources.
Zhuang
Yongliang
Y
Dept. of Food Chemistry and Nutrition, College of Food Science & Engineering, Ocean Univ. of China, Qingdao, Shandong 266003, P.R. China.
Hou
Hu
H
Zhao
Xue
X
Zhang
Zhaohui
Z
Li
Bafang
B
D000596:Amino Acids / Q000032:analysis; D000704:Analysis of Variance; D000818:Animals; D002374:Catalase / Q000378:metabolism; D003094:Collagen / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D005978:Glutathione / Q000032:analysis; D005979:Glutathione Peroxidase / Q000378:metabolism; D006025:Glycosaminoglycans / Q000032:analysis; D006868:Hydrolysis; D006909:Hydroxyproline / Q000032:analysis; D008055:Lipids / Q000032:analysis; D008297:Male; D008315:Malondialdehyde / Q000032:analysis; D051379:Mice; D008813:Mice, Inbred ICR; D020011:Protective Agents / Q000494:pharmacology*; D037401:Scyphozoa / Q000737:chemistry*; D012867:Skin / Q000737:chemistry / Q000378:metabolism / Q000528:radiation effects*; D015595:Skin Aging / Q000187:drug effects*; D013482:Superoxide Dismutase / Q000378:metabolism; D014466:Ultraviolet Rays / Q000009:adverse effects*
D000596:Amino Acids; D006025:Glycosaminoglycans; D008055:Lipids; D020011:Protective Agents; D008315:Malondialdehyde; D003094:Collagen; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005978:Glutathione; D006909:Hydroxyproline