Supraclavicular extraskeletal myxoid chondrosarcoma presenting with a sensorimotor polyneuropathy associated with anti-Hu antibodies.
Extraskeletal myxoid chondrosarcomas usually arise deep in the proximal extremities and limb girdles. Patients with this type of sarcoma have high rates of local recurrence and metastases, but do not typically have paraneoplastic syndromes. We report an unusual case of a 49-year-old man with anti-Hu syndrome in the setting of an extraskeletal myxoid chondrosarcoma. This case shows the importance of searching for antineural antibodies in oncologic patients with new neurologic deficits, and of having a judicious workup for occult malignancies in patients with known antineural antibodies.
Deik
Andres
A
Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York 10003, USA.
Azizi
Efat
E
Shapira
Ilan
I
Boniece
Irene R
IR
D001323:Autoantibodies / Q000097:blood*; D001859:Bone Neoplasms / Q000276:immunology / Q000473:pathology*; D002813:Chondrosarcoma / Q000276:immunology / Q000473:pathology*; D002968:Clavicle / Q000473:pathology; D003131:Combined Modality Therapy; D051959:ELAV Proteins / Q000276:immunology*; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D020364:Paraneoplastic Polyneuropathy / Q000276:immunology / Q000473:pathology*; D011878:Radiotherapy
D001323:Autoantibodies; D051959:ELAV Proteins; D016756:Immunoglobulins, Intravenous