title: Amide isosteres of oroidin: assessment of antibiofilm activity and C. elegans toxicity.
abstract: The synthesis and antibiofilm activities of sulfonamide, urea, and thiourea oroidin analogues are described. The most active derivative was able to selectively inhibit P. aeruginosa biofilm development and is also shown to be nontoxic upward of 1 mM to the development of C. elegans in comparison to other similar isosteric analogues and the natural product oroidin.
authors.affiliation: Department of Chemistry, North Carolina State University, Raleigh, North Carolina 27695, USA.
authors.forename: Justin J
authors.initials: JJ
authors.lastname: Richards
authors.forename: Samuel
authors.initials: S
authors.lastname: Reyes
authors.forename: Sean D
authors.initials: SD
authors.lastname: Stowe
authors.forename: Ashley T
authors.initials: AT
authors.lastname: Tucker
authors.forename: T Eric
authors.initials: TE
authors.lastname: Ballard
authors.forename: Laura D
authors.initials: LD
authors.lastname: Mathies
authors.forename: John
authors.initials: J
authors.lastname: Cavanagh
authors.forename: Christian
authors.initials: C
authors.lastname: Melander
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D018441:Biofilms / Q000187:drug effects*; D017173:Caenorhabditis elegans / Q000187:drug effects*; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000502:physiology; D011758:Pyrroles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis / Q000494:pharmacology; D013890:Thiourea / Q000138:chemical synthesis / Q000494:pharmacology; D014508:Urea / Q000138:chemical synthesis / Q000494:pharmacology
chemical_list: D000577:Amides; D000900:Anti-Bacterial Agents; D011758:Pyrroles; D013449:Sulfonamides; D014508:Urea; D013890:Thiourea; C077209:oroidin