Predicting adverse neonatal outcomes in fetuses with abdominal wall defects using prenatal risk factors.
OBJECTIVE
The aim of this study was to determine whether prenatal variables can predict adverse neonatal outcomes in fetuses with abdominal wall defects.


METHODS
A retrospective cohort study that used ultrasound and neonatal records for all cases of gastroschisis and omphalocele seen over a 16-year period. Cases with adverse neonatal outcomes were compared with noncases for multiple candidate predictive factors. Univariable and multivariable statistical methods were used to develop the prediction models, and effectiveness was evaluated using the area under the receiver operating characteristic curve.


RESULTS
Of 80 fetuses with gastroschisis, 29 (36%) had the composite adverse outcome, compared with 15 of 33 (47%) live neonates with omphalocele. Intrauterine growth restriction was the only significant variable in gastroschisis, whereas exteriorized liver was the only predictor in omphalocele. The areas under the curve for the prediction models with gastroschisis and omphalocele are 0.67 and 0.74, respectively.


CONCLUSIONS
Intrauterine growth restriction and exteriorization of the liver are significant predictors of adverse neonatal outcome with gastroschisis and omphalocele.
Nicholas
Sara S
SS
Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO, USA.
Stamilio
David M
DM
Dicke
Jeffery M
JM
Gray
Diana L
DL
Macones
George A
GA
Odibo
Anthony O
AO
D000328:Adult; D005260:Female; D005317:Fetal Growth Retardation / Q000453:epidemiology*; D020139:Gastroschisis / Q000453:epidemiology*; D006554:Hernia, Umbilical / Q000453:epidemiology*; D006801:Humans; D008423:Maternal Age; D006831:Polyhydramnios / Q000453:epidemiology; D011247:Pregnancy; D011256:Pregnancy Outcome; D012372:ROC Curve; D012307:Risk Factors; D055815:Young Adult