Fluoxetine-induced sleep bruxism in an adolescent treated with buspirone: a case report.
Sleep bruxism, the involuntary grinding and/or clenching of teeth during sleep, may occur in young children and may be secondary to medication use, especially selective serotonin reuptake inhibitors (SSRIs). The mesocortical disinhibition produced by SSRIs may lead to dopamine depletion that manifests itself as nocturnal bruxism, a specific form of akathisia. This may be prevented by using buspirone, a 5-HT1A agonist that reduces serotonergic activity and increases dopaminergic activity. This article reports on a case history of an adolescent with fluoxetine-induced bruxism that was successfully treated with buspirone. As SSRI use is on the rise for treating childhood psychiatric disorders, this case report highlights the importance of recognizing SSRI-induced bruxism and the possible related adverse dental side effects. Furthermore, this report supports the efficacy of a treatment strategy in adolescents, which has previously been reported only for adult patients.
Sabuncuoglu
Osman
O
Department of Child Psychiatry, Marmara University, Istanbul, Turkey.
Ekinci
Ozalp
O
Berkem
Meral
M
D000293:Adolescent; D002065:Buspirone / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000188:drug therapy; D005260:Female; D005473:Fluoxetine / Q000009:adverse effects*; D005500:Follow-Up Studies; D006801:Humans; D017286:Polysomnography; D017366:Serotonin Receptor Agonists / Q000627:therapeutic use*; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects*; D020186:Sleep Bruxism / Q000139:chemically induced* / Q000517:prevention & control
D002065:Buspirone; D005473:Fluoxetine; D017366:Serotonin Receptor Agonists; D017367:Selective Serotonin Reuptake Inhibitors