title: Uric acid concentrations are associated with insulin resistance and birthweight in normotensive pregnant women.
abstract: OBJECTIVE
  We sought to investigate whether uric acid concentrations are increased in pregnant women with insulin resistance and to correlate both with fetal growth.
  
  
  METHODS
  Uric acid, glucose, and insulin were measured in plasma at 20.4 (+/-2.0) weeks' gestation in 263 women. The association between uric acid and insulin resistance, as estimated using the homeostasis model assessment (HOMA), was analyzed and related to birthweights.
  
  
  RESULTS
  In 212 (80.6%) women who remained normotensive throughout pregnancy, HOMA increased 1.23 U per 1-mg/dL increase in uric acid (95% confidence interval, 1.07-1.42; P=.003). Infants born to normotensive women in the upper quartile of uric acid and lowest HOMA quartile weighed 435.6 g less than infants of women with highest uric acid and HOMA quartiles (P<.005).
  
  
  CONCLUSIONS
  Increasing uric acid concentrations were associated with insulin resistance in midpregnancy. Hyperuricemia was associated with lower birthweight in normotensive women, and this effect was attenuated by insulin resistance.
authors.affiliation: Department of Obstetrics, Gynecology, and Reproductive Services, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. laugsk@gmail.com
authors.forename: S Katherine
authors.initials: SK
authors.lastname: Laughon
authors.forename: Janet
authors.initials: J
authors.lastname: Catov
authors.forename: James M
authors.initials: JM
authors.lastname: Roberts
mesh_terms: D000328:Adult; D001724:Birth Weight; D001786:Blood Glucose; D005260:Female; D005317:Fetal Growth Retardation / Q000097:blood*; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000097:blood*; D033461:Hyperuricemia / Q000097:blood*; D007333:Insulin Resistance / Q000502:physiology*; D011247:Pregnancy; D014527:Uric Acid / Q000097:blood*; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D014527:Uric Acid