title: Preclinical animal model for de novo bone formation in human maxillary sinus.
abstract: OBJECTIVE
  Up to now the effect of bone-substitute materials on de novo bone formation has been tested in a variety of preclinical animal models. We hypothesized that there is no significant difference in bone regeneration after application of autogenous bone (AB) and bone substitutes in a porcine calvarial monocortical defect model and in human maxillary sinus.
  
  
  METHODS
  Twenty-four weeks after application of ss-tricalcium phosphate (betaTCP), hydroxyapatite (HA), and AB in each of 3 defects on the sculls of 6 adult pigs (N = 54) and the application in 44 sinus floor elevations (11x betaTCP, 6x HA and 24x AB) in 41 patients, bone regeneration rates where compared microradiographically. Wilcoxon rank-sum test was used for statistical analysis.
  
  
  RESULTS
  Comparing the human with the animal specimens microradiographically, no significant difference of the mineralization rate could be found.
  
  
  CONCLUSIONS
  The chosen porcine model is a valuable method for preclinical testing of bone-substitute materials in maxillofacial surgery.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany.
authors.forename: Karl Andreas
authors.initials: KA
authors.lastname: Schlegel
authors.forename: Stephan
authors.initials: S
authors.lastname: Rupprecht
authors.forename: Ljubinko
authors.initials: L
authors.lastname: Petrovic
authors.forename: Christian
authors.initials: C
authors.lastname: Honert
authors.forename: Safwan
authors.initials: S
authors.lastname: Srour
authors.forename: Cornelius
authors.initials: C
authors.lastname: von Wilmowsky
authors.forename: Endre
authors.initials: E
authors.lastname: Felszegy
authors.forename: Emeka
authors.initials: E
authors.lastname: Nkenke
authors.forename: Rainer
authors.initials: R
authors.lastname: Lutz
mesh_terms: D000540:Alveolar Ridge Augmentation / Q000379:methods; D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use; D001847:Bone Diseases / Q000601:surgery; D001857:Bone Matrix / Q000637:transplantation; D001861:Bone Regeneration / Q000502:physiology; D018786:Bone Substitutes / Q000627:therapeutic use*; D016025:Bone Transplantation / Q000379:methods*; D002113:Calcification, Physiologic / Q000502:physiology; D002130:Calcium Phosphates / Q000627:therapeutic use; D003758:Dental Implantation, Endosseous; D015921:Dental Implants; D004195:Disease Models, Animal; D017886:Durapatite / Q000627:therapeutic use; D005260:Female; D005624:Frontal Bone / Q000601:surgery; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008437:Maxilla / Q000601:surgery; D008443:Maxillary Sinus / Q000503:physiopathology / Q000601:surgery*; D008852:Microradiography; D008875:Middle Aged; D008903:Minerals / Q000627:therapeutic use; D010012:Osteogenesis / Q000502:physiology*; D013552:Swine
chemical_list: C077540:Bio-Oss; D001672:Biocompatible Materials; D018786:Bone Substitutes; D002130:Calcium Phosphates; D015921:Dental Implants; D008903:Minerals; C485817:beta-tricalcium phosphate; D017886:Durapatite