title: Imaging of tumor vasculature using Twente photoacoustic systems.
abstract: Photoacoustic imaging is a hybrid imaging modality based on the detection of acoustic waves generated by the absorption of short laser pulses in biological tissue. It combines the advantages of excellent contrast achieved in optical techniques with the high resolution of ultrasound imaging. In this article we present a review of the work done at the University of Twente to image tumor angiogenesis in vivo using this technique. We start with a description and the technical details of the different photoacoustic systems developed in our laboratory, with their validation on phantoms. We then discuss small-animal studies with results of serial imaging of angiogenesis over a 10-day period at the site of tumor induction in a rat. Further, we present clinical results using a photoacoustic mammoscope of breast cancer imaging based on angiogenesis-driven optical absorption contrast.
authors.affiliation: MIRA Institute for Biomedical Technology and Technical Medicine, Biophysical Engineering Group, Faculty of Science and Technology, University of Twente, P.O. Box 217, 7500AE Enschede, The Netherlands.
authors.forename: Jithin
authors.initials: J
authors.lastname: Jose
authors.forename: Srirang
authors.initials: S
authors.lastname: Manohar
authors.forename: Roy G M
authors.initials: RG
authors.lastname: Kolkman
authors.forename: W
authors.initials: W
authors.lastname: Steenbergen
authors.forename: Ton G
authors.initials: TG
authors.lastname: van Leeuwen
mesh_terms: D000162:Acoustics; D000818:Animals; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008027:Light; D057054:Molecular Imaging / Q000295:instrumentation / Q000379:methods*; D009369:Neoplasms / Q000098:blood supply*; D009389:Neovascularization, Pathologic