title: Mammalian apoptotic signalling pathways: multiple targets of protozoan parasites to activate or deactivate host cell death.
abstract: Programmed cell death is an essential mechanism of the host to combat infectious agents and to regulate immunity during infection. Consequently, activation and deactivation of the hosts' cell death pathways by protozoan parasites play critical roles in parasite control, pathogenesis, immune evasion and parasite dissemination within the host. Here, we discuss advances in the understanding of these fascinating host-parasite interactions with special emphasis on how protozoa can modulate the cell death apparatus of its host.
authors.affiliation: Institute for Medical Microbiology, Georg-August-University, Kreuzbergring 57, D-37075 Göttingen, Germany.
authors.forename: Kristin
authors.initials: K
authors.lastname: Graumann
authors.forename: Diana
authors.initials: D
authors.lastname: Hippe
authors.forename: Uwe
authors.initials: U
authors.lastname: Gross
authors.forename: Carsten G K
authors.initials: CG
authors.lastname: Lüder
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D001343:Autophagy; D006790:Host-Parasite Interactions / Q000502:physiology*; D006801:Humans; D007150:Immunohistochemistry; D008322:Mammals; D011528:Protozoan Infections / Q000469:parasitology / Q000473:pathology* / Q000503:physiopathology; D015800:Protozoan Proteins / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D015800:Protozoan Proteins