Spirobisnaphthalene analogues from the endophytic fungus Preussia sp.
A study on the chemical constituents of the endophytic fungus Preussia sp. led to the isolation of three new spirobisnaphthalene analogues, spiropreussione A (1), spiropreussione B (2), and spiropreussomerin A (3). Compound 2 is a spirobisnaphthalene analogue with a cyclopenteno-naphthoindene fragment bridged to a 1,8-dioxygenated naphthalene fragment, and compound 1 is the second compound in this series with a spiro-nonadiene skeleton. The structures of 1-3 were elucidated using spectroscopic data interpretation. Compound 1 showed cytotoxicity toward A2780 and BEL-7404 cells with IC(50) values of 2.4 and 3.0 microM, respectively, and weak activity against Staphylococcus aureus (CMCC B26003) with a MIC value of 25 microM.
Chen
Xiaomei
X
Biotechnology Research Center, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
Shi
Qiyuan
Q
Lin
Geng
G
Guo
Shunxing
S
Yang
Junshan
J
D001203:Ascomycota / Q000737:chemistry*; D002681:China; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013141:Spiro Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects
D013141:Spiro Compounds; C544229:spiropreussione A; C544230:spiropreussione B; C544231:spiropreussomerin A