Regenerative medicine in the treatment of peripheral arterial disease.
The last decade has witnessed a dramatic increase in the mechanistic understanding of angiogenesis and arteriogenesis, the two processes by which the body responds to obstruction of large conduit arteries. This knowledge has been translated into novel therapeutic approaches to the treatment of peripheral arterial disease, a condition characterized by progressive narrowing of lower extremity arteries and heretofore solely amenable to surgical revascularization. Clinical trials of molecular, genetic, and cell-based treatments for peripheral artery obstruction have generally provided encouraging results.
Sneider
Erica B
EB
Department of Surgery, Division of Vascular Surgery, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.
Nowicki
Philip T
PT
Messina
Louis M
LM
D000818:Animals; D001158:Arteries / Q000473:pathology; D002986:Clinical Trials as Topic; D018450:Disease Progression; D005260:Female; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods; D006801:Humans; D000860:Hypoxia; D009389:Neovascularization, Pathologic; D016491:Peripheral Vascular Diseases / Q000235:genetics / Q000628:therapy*; D010641:Phenotype; D044968:Regenerative Medicine / Q000379:methods*; D013314:Stress, Mechanical; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
D042461:Vascular Endothelial Growth Factor A