Coumestan glycosides from the stem bark of Cylicodiscus gabunensis.
Two new coumestan glycosides, coumestoside C (1) and coumestoside D (2), were isolated from the stem bark of Cylicodiscus gabunensis Harms. Their structures were established by spectroscopic means and chemical transformations as 9-O-alpha-L-rhamnopyranosyl-3-hydroxy-4-(5'-hydroxy-3'-methylbut-2'E-enyl) coumestan (1) and 9-O-beta-D-galactopyranosyl-3-O- prenyl-4-hydroxycoumestan. Coumestoside C exhibited antimicrobial activity against Proteus vulgaris.
Nchancho
Kazie
K
Department of Organic Chemistry, Faculty of Science, University of Yaoundi I, P.O. Box 812, Cameroon.
Kouam
Jacques
J
Tane
Pierre
P
Kuete
Victor
V
Watchueng
Jean
J
Fomum
Zacharias T
ZT
D002241:Carbohydrates / Q000737:chemistry; D003374:Coumarins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D007887:Fabaceae / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification; D006868:Hydrolysis; D008826:Microbial Sensitivity Tests; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D011514:Proteus vulgaris / Q000187:drug effects; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D002241:Carbohydrates; D003374:Coumarins; D006027:Glycosides; D010936:Plant Extracts; C505898:coumestan