The energy-redox axis in aging and age-related neurodegeneration.
Decrease in mitochondrial energy-transducing capacity is a feature of the aging process that accompanies redox alterations, such as increased generation of mitochondrial oxidants, altered GSH status, and increased protein oxidation. The decrease in mitochondrial energy-transducing capacity and altered redox status should be viewed as a concerted process that embodies the mitochondrial energy-redox axis and is linked through various mechanisms including: (a) an inter-convertible reducing equivalents pool (i.e., NAD(P)(+)/NAD(P)H) and (b) redox-mediated protein post-translational modifications involved in energy metabolism. The energy-redox axis provides the rationale for therapeutic approaches targeted to each or both component(s) of the axis that effectively preserves or improve mitochondrial function and that have implications for aging and age-related neurodegenerative disorders.
Yap
Li-Peng
LP
Department of Molecular Pharmacology & Pharmaceutical Sciences, University of Southern California, Los Angeles, 90089-9121, USA.
Garcia
Jerome V
JV
Han
Derick
D
Cadenas
Enrique
E
D000375:Aging / Q000378:metabolism*; D016503:Drug Delivery Systems / Q000379:methods; D004734:Energy Metabolism / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D008954:Models, Biological; D019636:Neurodegenerative Diseases / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism; D010084:Oxidation-Reduction / Q000187:drug effects*