title: Costs associated with capecitabine or 5-fluorouracil monotherapy after surgical resection in patients with colorectal cancer.
abstract: OBJECTIVE
  To compare chemotherapy-related and total medical costs among patients with colorectal cancer (CRC) receiving capecitabine or 5-fluorouracil (5-FU) monotherapy after surgical resection.
  
  
  METHODS
  This retrospective, claim-based study utilized the Thomson Reuters Market Scan(R) databases to identify 1,396 CRC patients who received capecitabine or 5-FU monotherapy within 90 days of surgical resection from 2003 through 2006. Propensity score matching addressed selection bias, and multivariate models estimated adjusted relative risks of treatment-related complications and medical costs of matched cohorts.
  
  
  RESULTS
  Capecitabine users incurred USD 740 less in total direct medical costs (p = 0.003) and USD 785 less in chemotherapy-related costs (p < 0.0001) than 5-FU users. Although drug acquisition cost was higher for capecitabine than for 5-FU (USD 958 vs. USD 71, p < 0.0001), chemotherapy administration cost was lower (USD 76 vs. USD 1,062, p < 0.0001). The unadjusted (610 vs. 1,960 events per 1,000 person-months) and adjusted risks (47%) were lower for capecitabine than 5-FU for any complication, and specifically for bone marrow (67%), gastrointestinal (50%), and constitutional (41%) complications (p < 0.0001, all comparisons).
  
  
  CONCLUSIONS
  Adjuvant capecitabine monotherapy was associated with lower total medical and chemotherapy-related costs than 5-FU. Reduced complications and costs associated with capecitabine administration offset the higher acquisition cost.
authors.affiliation: Yale Cancer Center, Yale University School of Medicine, New Haven, CT 06520, USA. chueyale@yahoo.com
authors.forename: Edward
authors.initials: E
authors.lastname: Chu
authors.forename: Nianwen
authors.initials: N
authors.lastname: Shi
authors.forename: Wenhui
authors.initials: W
authors.lastname: Wei
authors.forename: Johanna C
authors.initials: JC
authors.lastname: Bendell
authors.forename: Thomas
authors.initials: T
authors.lastname: Cartwright
mesh_terms: D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D000069287:Capecitabine; D015179:Colorectal Neoplasms / Q000188:drug therapy*; D003841:Deoxycytidine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000191:economics / Q000627:therapeutic use; D005260:Female; D005472:Fluorouracil / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000191:economics / Q000627:therapeutic use*; D017048:Health Care Costs; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D000964:Antimetabolites, Antineoplastic; D003841:Deoxycytidine; D000069287:Capecitabine; D005472:Fluorouracil