Ultrasound promoted greener synthesis of spiro[indole-3,5'-[1,3]oxathiolanes in water.
An aqueous mediated novel synthesis of substituted 2'amino-4'benzoyl-2'-methyl spiro[indole 3,5'-[1,3]oxathiolane]-2(1H)-ones (2a-f) was carried out from the reaction of spiro [indole-3,2'-oxiranes] (1a-f) with thioacetamide in the presence of LiBr as catalyst. The reaction was carried out under both microwaves and sonication and results were also compared with conventional method. In general, improvement in rate and yields observed when reaction was carried out under sonication as compared to microwave irradiation and conventional method.
Dandia
Anshu
A
Department of Chemistry, University of Rajasthan, Jaipur, India. dranshudandia@yahoo.co.in
Singh
Ruby
R
Bhaskaran
Sumit
S
D002626:Chemistry, Pharmaceutical / Q000379:methods*; D015195:Drug Design; D055772:Green Chemistry Technology; D007211:Indoles / Q000737:chemistry; D013058:Mass Spectrometry / Q000379:methods; D008872:Microwaves; D008956:Models, Chemical; D012822:Silicon Dioxide; D012997:Solvents / Q000737:chemistry; D013053:Spectrophotometry / Q000379:methods; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013844:Thiazoles / Q000737:chemistry*; D014465:Ultrasonics; D014867:Water / Q000737:chemistry*
D007211:Indoles; D012997:Solvents; D013141:Spiro Compounds; D013844:Thiazoles; D014867:Water; D012822:Silicon Dioxide