title: Anti-oxidative effects of Phellinus linteus and red ginseng extracts on oxidative stress-induced DNA damage.
abstract: Anti-oxidative effect of Phellinus linteus (P. linteus) and red ginseng extracts on DNA damage induced by reactive oxygen species (ROS) were investigated in this study. P. linteus (PLE) and red ginseng extracts (RGE) inhibited the breaking of E. coli ColE1 plasmid DNA strands as well as nuclear DNA of rat hepatocytes damaged by oxidative stress. In addition, a reaction mixture of PLE and RGE showed synergistic inhibitory effect against DNA damage. These results suggest that PLE and RGE have a cellular defensive effect against DNA damage induced by ROS.
authors.affiliation: Department of Life Science, Hallym University, Chunchon 202-702, Korea.
authors.forename: Byung-Jae
authors.initials: BJ
authors.lastname: Park
authors.forename: Yeong-Seok
authors.initials: YS
authors.lastname: Lim
authors.forename: Hee-Jung
authors.initials: HJ
authors.lastname: Lee
authors.forename: Won Sik
authors.initials: WS
authors.lastname: Eum
authors.forename: Jinseu
authors.initials: J
authors.lastname: Park
authors.forename: Kyu Hyung
authors.initials: KH
authors.lastname: Han
authors.forename: Soo Young
authors.initials: SY
authors.lastname: Choi
authors.forename: Kil Soo
authors.initials: KS
authors.lastname: Lee
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002467:Cell Nucleus / Q000187:drug effects / Q000378:metabolism; D053960:DNA Breaks / Q000187:drug effects; D004249:DNA Damage; D004269:DNA, Bacterial / Q000378:metabolism; D005057:Eukaryotic Cells / Q000187:drug effects / Q000378:metabolism; D005296:Ferrous Compounds / Q000494:pharmacology; D022781:Hepatocytes / Q000187:drug effects / Q000378:metabolism; D006861:Hydrogen Peroxide / Q000494:pharmacology; D018384:Oxidative Stress / Q000187:drug effects*; D005894:Panax / Q000378:metabolism*; D000084682:Phellinus; D010936:Plant Extracts / Q000494:pharmacology*; D010957:Plasmids / Q000378:metabolism; D011134:Polysaccharides / Q000494:pharmacology*; D051381:Rats
chemical_list: D000975:Antioxidants; D004269:DNA, Bacterial; D005296:Ferrous Compounds; C526145:Phellinus linteus extract; D010936:Plant Extracts; D011134:Polysaccharides; D006861:Hydrogen Peroxide; C029451:ferrous chloride