Actions and interactions of alcohol and insulin-like growth factor-1 on female pubertal development.
Alcohol (ALC) is a drug that is capable of disrupting reproductive function in adolescent humans, as well as immature rhesus monkeys and rats. Critical to determining the mechanism(s) of the effects of ALC on the pubertal process is to have a better understanding of the important events involved in the initiation of puberty. For years it has been hypothesized that there may be metabolic signals capable of linking somatic growth to the activation of the reproductive system at the time of puberty. In recent years it has been shown that insulin-like growth factor-1 (IGF-1) is one such signal that plays an early role in the pubertal process. In this review, we will describe the actions and interactions of ALC and IGF-1 on molecular and physiological processes associated with pubertal development.
Dees
W Les
WL
Department of Integrative Biosciences, Texas A&M University, College Station, TX, USA. ldees@cvm.tamu.edu
Srivastava
Vinod
V
Hiney
Jill K
JK
D000293:Adolescent; D000818:Animals; D002492:Central Nervous System Depressants / Q000494:pharmacology*; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007031:Hypothalamus / Q000502:physiology; D007334:Insulin-Like Growth Factor I / Q000502:physiology*; D010907:Pituitary Hormones / Q000502:physiology; D011627:Puberty / Q000187:drug effects*; D051381:Rats; D012098:Reproduction / Q000187:drug effects
D002492:Central Nervous System Depressants; D010907:Pituitary Hormones; D000431:Ethanol; D007334:Insulin-Like Growth Factor I