Steroid hormone pulsing drives cyclic gene expression.
Transcriptional cycling of activated glucocorticoid receptor (GR) and ultradian glucocorticoid secretion are well established processes. Ultradian hormone release is now shown to result in pulsatile gene transcription through dynamic exchange of GR with the target-gene promoter and GR cycling through the chaperone machinery.
Desvergne
Béatrice
B
Héligon
Christophe
C
D000305:Adrenal Cortex Hormones / Q000097:blood / Q000494:pharmacology*; D000818:Animals; D005786:Gene Expression Regulation / Q000187:drug effects*; D006801:Humans; D051379:Mice; D008954:Models, Biological; D051381:Rats; D011965:Receptors, Glucocorticoid / Q000378:metabolism; D020218:Response Elements / Q000235:genetics; D014158:Transcription, Genetic / Q000187:drug effects
D000305:Adrenal Cortex Hormones; D011965:Receptors, Glucocorticoid