Modeling the cardiac Na(+)/H (+) exchanger based on major experimental findings.
Na(+)-H(+) exchanger (NHE) is the main acid extruder in cardiac myocytes. We review the experimental findings of ion-dependency of NHE activity, and the mathematical modeling developed so far. In spite of extensive investigation, many unsolved questions still remain. We consider that the precise description of NHE activity with mathematical models elucidates the roles of NHE in maintaining ionic homeostasis, especially under pathophysiological conditions.
Cha
Chae Young
CY
Biosimulation Project, Faculty of Bioinformatics, Ritsumeikan University, Kyoto, Japan.
Noma
Akinori
A
D000818:Animals; D006801:Humans; D006863:Hydrogen-Ion Concentration; D017136:Ion Transport / Q000502:physiology; D007700:Kinetics; D008954:Models, Biological; D009206:Myocardium / Q000378:metabolism; D011522:Protons; D012964:Sodium / Q000378:metabolism*; D017923:Sodium-Hydrogen Exchangers / Q000502:physiology*
D011522:Protons; D017923:Sodium-Hydrogen Exchangers; D012964:Sodium