Population normative data for the 10/66 Dementia Research Group cognitive test battery from Latin America, India and China: a cross-sectional survey.
BACKGROUND
1) To report site-specific normative values by age, sex and educational level for four components of the 10/66 Dementia Research Group cognitive test battery; 2) to estimate the main and interactive effects of age, sex, and educational level by site; and 3) to investigate the effect of site by region and by rural or urban location.


METHODS
Population-based cross-sectional one phase catchment area surveys were conducted in Cuba, Dominican Republic, Venezuela, Peru, Mexico, China and India. The protocol included the administration of the Community Screening Instrument for Dementia (CSI 'D', generating the COGSCORE measure of global function), and the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) verbal fluency (VF), word list memory (WLM, immediate recall) and recall (WLR, delayed recall) tests. Only those free of dementia were included in the analysis.


RESULTS
Older people, and those with less education performed worse on all four tests. The effect of sex was much smaller and less consistent. There was a considerable effect of site after accounting for compositional differences in age, education and sex. Much of this was accounted for by the effect of region with Chinese participants performing better, and Indian participants worse, than those from Latin America. The effect of region was more prominent for VF and WLM than for COGSCORE and WLR.


CONCLUSIONS
Cognitive assessment is a basic element for dementia diagnosis. Age- and education-specific norms are required for this purpose, while the effect of gender can probably be ignored. The basis of cultural effects is poorly understood, but our findings serve to emphasise that normative data may not be safely generalised from one population to another with quite different characteristics. The minimal effects of region on COGSCORE and WLR are reassuring with respect to the cross-cultural validity of the 10/66 dementia diagnosis, which uses only these elements of the 10/66 battery.
Sosa
Ana Luisa
AL
National Institute of Neurology and Neurosurgery of Mexico, Mexico City, Mexico. drasosa@hotmail.com
Albanese
Emiliano
E
Prince
Martin
M
Acosta
Daisy
D
Ferri
Cleusa P
CP
Guerra
Mariella
M
Huang
Yueqin
Y
Jacob
K S
KS
de Rodriguez
Juan Llibre
JL
Salas
Aquiles
A
Yang
Fang
F
Gaona
Ciro
C
Joteeshwaran
At
A
Rodriguez
Guillermina
G
de la Torre
Gabriela Rojas
GR
Williams
Joseph D
JD
Stewart
Robert
R
D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002681:China / Q000453:epidemiology; D003431:Cross-Cultural Comparison; D003430:Cross-Sectional Studies; D003704:Dementia / Q000453:epidemiology*; D004522:Educational Status; D006801:Humans; D007194:India / Q000453:epidemiology; D007843:Latin America / Q000453:epidemiology; D008297:Male; D009483:Neuropsychological Tests / Q000706:statistics & numerical data*; D012016:Reference Values; D012737:Sex Factors