title: The prevalence of non-classic adrenal hyperplasia among Turkish women with hyperandrogenism.
abstract: The prevalence of non-classic adrenal hyperplasia (NCAH) among Turkish women with hirsutism has not been established so far. Thus, we aimed to evaluate the prevalence of 21-hydroxylase (21-OH) deficiency by ACTH stimulation test among hirsute women. The study population consisted of 285 premenopousal women, aged 16-46 years (mean: 23.2 ± 0.3). All were hirsute and hyperandrogenic. Androgen secreting tumors of the ovaries and the adrenal glands were excluded as well as thyroid dysfunction and hyperprolactinemia. All the patients were evaluated by 0.25 mg (i.v.) ACTH stimulation test and 17-OHP responses were obtained at 30 and 60 min. The diagnosis of NCAH due to 21-OH deficiency was considered in patients with the poststimulation 17-OHP level exceed 10 ng/ml. Six (2.1%) of the patients had NCAH due to 21-OH deficiency confirmed by genotyping. The rest of the patients were polycystic ovary syndrome (n = 166, 58.2%) and idiopathic hyperandrogenemia (n = 113, 39.7%). There were no patients with idiopathic hirsutism because patients with normal serum androgen levels were excluded. This first and most extensive national study investigating NCAH prevalence among Turkish population showed that NCAH is not prevalent in this population.
authors.affiliation: Department of Endocrinology, Erciyes University Medical School, Kayseri, Turkey.
authors.forename: Kursad
authors.initials: K
authors.lastname: Unluhizarci
authors.forename: Mustafa
authors.initials: M
authors.lastname: Kula
authors.forename: Munis
authors.initials: M
authors.lastname: Dundar
authors.forename: Fatih
authors.initials: F
authors.lastname: Tanriverdi
authors.forename: Shoshana
authors.initials: S
authors.lastname: Israel
authors.forename: Ramis
authors.initials: R
authors.lastname: Colak
authors.forename: Hatice Sebila
authors.initials: HS
authors.lastname: Dokmetas
authors.forename: Hulusi
authors.initials: H
authors.lastname: Atmaca
authors.forename: Mithat
authors.initials: M
authors.lastname: Bahceci
authors.forename: Mustafa Kemal
authors.initials: MK
authors.lastname: Balci
authors.forename: Abdurrahman
authors.initials: A
authors.lastname: Comlekci
authors.forename: Habip
authors.initials: H
authors.lastname: Bilen
authors.forename: Ersin
authors.initials: E
authors.lastname: Akarsu
authors.forename: Cihangir
authors.initials: C
authors.lastname: Erem
authors.forename: Fahrettin
authors.initials: F
authors.lastname: Kelestimur
mesh_terms: D019326:17-alpha-Hydroxyprogesterone / Q000097:blood; D000293:Adolescent; D000312:Adrenal Hyperplasia, Congenital / Q000453:epidemiology* / Q000235:genetics / Q000378:metabolism; D000324:Adrenocorticotropic Hormone / Q000172:deficiency / Q000378:metabolism; D000328:Adult; D004247:DNA / Q000737:chemistry / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D017588:Hyperandrogenism / Q000453:epidemiology* / Q000235:genetics / Q000378:metabolism; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D015995:Prevalence; D013255:Steroid 21-Hydroxylase / Q000235:genetics; D014421:Turkey / Q000453:epidemiology; D055815:Young Adult
chemical_list: D019326:17-alpha-Hydroxyprogesterone; D000324:Adrenocorticotropic Hormone; D004247:DNA; D013255:Steroid 21-Hydroxylase