title: Plasmid-mediated fluoroquinolone efflux pump gene, qepA, in Escherichia coli clinical isolates in Korea.
abstract: The qepA gene was detected in 4 (0.6%) of 621 nonduplicate Escherichia coli clinical isolates collected from blood cultures in Korea. Three of the 4 qepA-positive isolates contained bla(CTX-M-14) and/or bla(TEM-1) genes, but not the E8700 isolate. The qepA gene was successfully transferred and conferred resistance to hydrophilic quinolones, such as norfloxacin and ciprofloxacin, in the recipient. The gene was located in part of IS26. Two isolates were linked to the truncated rmtB gene.
authors.affiliation: Department of Infectious Diseases, Asan Medical Center and Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea.
authors.forename: Eun Sil
authors.initials: ES
authors.lastname: Kim
authors.forename: Jin-Yong
authors.initials: JY
authors.lastname: Jeong
authors.forename: Sang-Ho
authors.initials: SH
authors.lastname: Choi
authors.forename: Sang-Oh
authors.initials: SO
authors.lastname: Lee
authors.forename: Sung-Han
authors.initials: SH
authors.lastname: Kim
authors.forename: Mi-Na
authors.initials: MN
authors.lastname: Kim
authors.forename: Jun Hee
authors.initials: JH
authors.lastname: Woo
authors.forename: Yang Soo
authors.initials: YS
authors.lastname: Kim
mesh_terms: D016470:Bacteremia / Q000097:blood / Q000382:microbiology; D001426:Bacterial Proteins / Q000235:genetics; D004754:Enterobacter / Q000235:genetics; D004756:Enterobacteriaceae Infections / Q000097:blood / Q000382:microbiology; D004926:Escherichia coli / Q000235:genetics* / Q000302:isolation & purification / Q000378:metabolism; D004927:Escherichia coli Infections / Q000097:blood / Q000382:microbiology*; D029968:Escherichia coli Proteins / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D007711:Klebsiella pneumoniae / Q000235:genetics; D007723:Korea; D010957:Plasmids / Q000235:genetics; D016133:Polymerase Chain Reaction
chemical_list: D001426:Bacterial Proteins; D029968:Escherichia coli Proteins; C524438:QepA protein, E coli