Major cell death pathways at a glance.
Cell death is a crucial process during development, homeostasis and immune regulation of multicellular organisms, and its dysregulation is associated with numerous pathologies. Cell death is often induced upon pathogen infection as part of the defense mechanism, and pathogens have evolved strategies to modulate host cell death. In this review, we will discuss the molecular mechanisms and physiological relevance of four major types of programmed cell death, namely apoptosis, necrosis, autophagic cell death and pyroptosis.
Duprez
Linde
L
VIB, Department for Molecular Biomedical Research, Unit for Molecular Signaling and Cell Death, Technologiepark 927, B-9052 Ghent (Zwijnaarde), Belgium.
Wirawan
Ellen
E
Vanden Berghe
Tom
T
Vandenabeele
Peter
P
D000818:Animals; D016923:Cell Death / Q000502:physiology*; D054884:Host-Pathogen Interactions / Q000502:physiology*; D006801:Humans; D007239:Infections; D008954:Models, Biological; D015398:Signal Transduction / Q000502:physiology*