Medicine. Disrupting Hedgehog may reverse advanced cancer, if only temporarily.
Kean
Sam
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D000328:Adult; D000813:Anilides; D000818:Animals; D000970:Antineoplastic Agents / Q000378:metabolism / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000378:metabolism / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D002280:Basal Cell Carcinoma / Q000188:drug therapy; D019008:Drug Resistance, Neoplasm; D053823:Hedgehog Proteins / Q000378:metabolism; D006801:Humans; D008297:Male; D008527:Medulloblastoma / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D051379:Mice; D017354:Point Mutation; D011485:Protein Binding; D011725:Pyridines; D043562:Receptors, G-Protein-Coupled / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects; D012878:Skin Neoplasms / Q000188:drug therapy; D000072086:Smoothened Receptor
D000813:Anilides; D000970:Antineoplastic Agents; D001562:Benzimidazoles; D053823:Hedgehog Proteins; C538724:HhAntag691; D011725:Pyridines; D043562:Receptors, G-Protein-Coupled; C491023:SMO protein, human; D000072086:Smoothened Receptor