title: Oxidant/antioxidant status, lipids and hormonal profile in overweight women with breast cancer.
abstract: This study was carried out to determine the relationships between leptin concentrations, lipid alterations, oxidant/ antioxidant status, in vitro LDL oxidizability and LDL-fatty acid composition in overweight breast cancer patients. Glucose, insulin, leptin, lipids, LDL-cholesteryl ester fatty acids, markers of oxidant status (MDA, Hydroperoxides, carbonyl proteins, conjugated dienes) and markers of antioxidant status (vitamins A, C, E, erythrocyte activities of the enzymes superoxide dismutase, SOD, catalase, glutathione peroxidase,GPx, and glutathione reductase, GR and the serum total antioxidant status, ORAC) were investigated in breast cancer patients and in control women. Our findings showed that insulin, leptin, triglyceride, cholesterol and LDL-C concentrations were increased in patients compared to controls. ORAC and vitamin C and E values were lower while plasma hydroperoxide, carbonyl protein and conjugated diene levels, SOD and GPx activities were higher than in controls. Alterations in LDL-fatty acid composition were associated with their enhanced oxidative susceptibility. There were significant positive correlations between leptin concentrations and LDL-C, hydroperoxides, carbonyl proteins, SOD activity, baseline conjugated diene levels and oxidation rate, and significant negative correlations between leptin and ORAC, lag time and LDL-PUFA in patients. In conclusion, breast cancer is associated with lipid alterations and enhanced oxidative stress linked to high leptin levels in overweight.
authors.affiliation: Department of Molecular and Cellular Biology, Faculty of Sciences, University of Tlemcen, Tlemcen, Algeria.
authors.forename: Naima
authors.initials: N
authors.lastname: Badid
authors.forename: Fatima Zohra Baba
authors.initials: FZ
authors.lastname: Ahmed
authors.forename: Hafida
authors.initials: H
authors.lastname: Merzouk
authors.forename: Slimane
authors.initials: S
authors.lastname: Belbraouet
authors.forename: Nassima
authors.initials: N
authors.lastname: Mokhtari
authors.forename: Sid Ahmed
authors.initials: SA
authors.lastname: Merzouk
authors.forename: Riad
authors.initials: R
authors.lastname: Benhabib
authors.forename: Djalloul
authors.initials: D
authors.lastname: Hamzaoui
authors.forename: Michel
authors.initials: M
authors.lastname: Narce
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D001205:Ascorbic Acid / Q000097:blood; D015992:Body Mass Index; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D002374:Catalase / Q000378:metabolism; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D006801:Humans; D020738:Leptin / Q000097:blood; D008074:Lipoproteins / Q000097:blood; D008875:Middle Aged; D009367:Neoplasm Staging; D050177:Overweight / Q000378:metabolism*; D018384:Oxidative Stress / Q000502:physiology*; D013482:Superoxide Dismutase / Q000378:metabolism; D014801:Vitamin A / Q000097:blood; D014810:Vitamin E / Q000097:blood
chemical_list: D000975:Antioxidants; D020738:Leptin; D008074:Lipoproteins; D014801:Vitamin A; D014810:Vitamin E; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase; D001205:Ascorbic Acid