Epigenetic programming of diverse glucocorticoid response and inflammatory/immune-mediated disease.
Glucocorticoid plays a fundamental role in maintaining immune homeostasis. Resistance to glucocorticoids is a potential etiology of inflammatory/immune-mediated disease. Most of the glucocorticoid effects are mediated by glucocorticoid receptor (GR), which has a complicated promoter region with multiple promoters. Studies have found that the methylation pattern of GR promoter is highly individual, which may contribute to the diverse glucocorticoid responds. Early life is a critical time for epigenetic programming of the body in which methylation imprints are established. Here we propose a hypothesis that connects the adverse early life events and the development of inflammatory/immune-mediated disease through an epigenetic mechanism, the methylation of GR gene.
Chen
Peisong
P
Department of Laboratory Medicine, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.
Jiang
Tang
T
Ouyang
Juan
J
Cui
Yingpeng
Y
Chen
Yili
Y
D019175:DNA Methylation; D044127:Epigenesis, Genetic; D006801:Humans; D007154:Immune System Diseases / Q000235:genetics*; D007249:Inflammation / Q000235:genetics*; D008962:Models, Theoretical; D011401:Promoter Regions, Genetic; D011965:Receptors, Glucocorticoid / Q000235:genetics / Q000502:physiology*
D011965:Receptors, Glucocorticoid