title: Hydrolysis of 2,4-dithiophenobarbital.
abstract: Hydrolysis of 2,4-dithiophenobarbital in aqueous solutions of pH 2-12 was investigated at 40 and 60 degrees C using UV spectrophotometry. The values of reaction order, rate constants, pKa1 and pKa2 and activation energy were determined. The preliminary estimation of degradation products was accomplished using thin layer chromatography. The major products were isolated by circular chromatography and identified by spectroscopic and classical methods.
authors.affiliation: Department of Organic Chemistry, Jagiellonian University, Faculty of Pharmacy 9 Medyczna St., 30-688 Kraków, Poland. mftarsa@cyf-kr.edu.pl
authors.forename: Monika
authors.initials: M
authors.lastname: Tarsa
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Zuchowski
authors.forename: Anna
authors.initials: A
authors.lastname: Stasiewicz-Urban
authors.forename: Jacek
authors.initials: J
authors.lastname: Bojarski
mesh_terms: D001463:Barbiturates / Q000737:chemistry; D002021:Buffers; D002855:Chromatography, Thin Layer; D006868:Hydrolysis; D007700:Kinetics; D010634:Phenobarbital / Q000031:analogs & derivatives* / Q000737:chemistry*; D012997:Solvents; D013056:Spectrophotometry, Ultraviolet
chemical_list: C543801:2,4-dithiophenobarbital; D001463:Barbiturates; D002021:Buffers; D012997:Solvents; D010634:Phenobarbital