title: Risk Factors in first presentation acute coronary syndromes (ACS): how do we move from population to individualized risk prediction?
abstract: Patients with acute coronary syndromes (ACS) have a poor short- and long-term prognosis. We sought to examine the presence of established coronary risk factors in contemporary patients presenting with an ACS for the first time and no known coronary artery disease (CAD) in the past. The study was conducted in 3171 consecutive patients admitted with the diagnosis of ACS. Of these, 941 patients (30%) had the admission as the first occurrence of ACS and no prior history of CAD. We studied the degree to which these first presenters with ACS had 1 or more established risk factors. We found that 98% of patients presenting with an ACS for the first time and no previous CAD had at least 1 established risk factor. Current population-based screening efforts must be improved to allow more effective prevention strategies and more individualized risk prediction.
authors.affiliation: Department of Cardiovascular Medicine, Tufts University School of Medicine, Bay State Medical Center, Springfield, Massachusetts 01109, USA. fadisaab17@hotmail.com
authors.forename: Fadi
authors.initials: F
authors.lastname: Saab
authors.forename: Debabrata
authors.initials: D
authors.lastname: Mukherjee
authors.forename: Hitinder
authors.initials: H
authors.lastname: Gurm
authors.forename: Apurva
authors.initials: A
authors.lastname: Motivala
authors.forename: Daniel
authors.initials: D
authors.lastname: Montgomery
authors.forename: Eva
authors.initials: E
authors.lastname: Kline-Rogers
authors.forename: Melvyn
authors.initials: M
authors.lastname: Rubenfire
authors.forename: Kim
authors.initials: K
authors.lastname: Eagle
mesh_terms: D054058:Acute Coronary Syndrome / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology; D000367:Age Factors; D000368:Aged; D016757:Death, Sudden, Cardiac / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000453:epidemiology; D008297:Male; D008824:Michigan / Q000453:epidemiology; D008875:Middle Aged; D009017:Morbidity; D011446:Prospective Studies; D018570:Risk Assessment; D012907:Smoking / Q000009:adverse effects* / Q000453:epidemiology; D013997:Time Factors