title: Donor-specific HLA antibody response in clonal deletion.
abstract: 1. A total of 61 patients were treated with a clonal deletion protocol and transplanted without planned post-transplant immunosuppression. 2. Twenty-nine (48%) patients did not develop any donor-specific anti-HLA antibodies after the transplant, with a median follow-up of 158 days and a mean sCr of 2.1 mg/dL at the last follow-up. 3. Only 23% of the patients who received a DST of 60 mL produced DSA after the transplant, while 68% of the patients who received a bigger DST dose did. 4. Small doses of donor-specific transfusions (60 mL) elicited smaller specific responses, allowing efficient deletion of the reacting clones, creating conditions in which donor-specific anti-HLA antibodies were not produced. 5. A better deleting agent is needed to achieve higher rates of success using the clonal deletion protocol.
authors.affiliation: 'erasaki Foundation Laboratory, Los Angeles, CA, USA.
authors.forename: H
authors.initials: H
authors.lastname: Kaneku
authors.forename: A
authors.initials: A
authors.lastname: Idica
authors.forename: M J
authors.initials: MJ
authors.lastname: Everly
authors.forename: P I
authors.initials: PI
authors.lastname: Terasaki
authors.forename: A
authors.initials: A
authors.lastname: Feroz
authors.forename: A V
authors.initials: AV
authors.lastname: Vanikar
authors.forename: V
authors.initials: V
authors.lastname: Shankar
authors.forename: V B
authors.initials: VB
authors.lastname: Trivedi
authors.forename: P R
authors.initials: PR
authors.lastname: Modi
authors.forename: S I
authors.initials: SI
authors.lastname: Khemchandani
authors.forename: S D
authors.initials: SD
authors.lastname: Dave
authors.forename: H L
authors.initials: HL
authors.lastname: Trivedi
mesh_terms: D000293:Adolescent; D000328:Adult; D000906:Antibodies / Q000097:blood*; D002648:Child; D017637:Clonal Deletion; D005260:Female; D006084:Graft Rejection / Q000276:immunology / Q000517:prevention & control*; D006085:Graft Survival; D006680:HLA Antigens / Q000276:immunology*; D006648:Histocompatibility; D006801:Humans; D016030:Kidney Transplantation; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D019172:Transplantation Conditioning / Q000379:methods*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000906:Antibodies; D006680:HLA Antigens