Comparative assessment of siRNA and shRNA off target effects: what is slowing clinical development.
This review considers comparisons of the off-target effects of siRNA to shRNA and their potential impact on the efficacy and toxicity of RNAi based therapeutics.
Rao
D D
DD
Gradalis Inc., Dallas, TX, USA.
Senzer
N
N
Cleary
M A
MA
Nemunaitis
J
J
D015316:Genetic Therapy; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism; D009369:Neoplasms / Q000628:therapy; D034622:RNA Interference / Q000502:physiology*; D034741:RNA, Small Interfering / Q000235:genetics / Q000378:metabolism*
D035683:MicroRNAs; D034741:RNA, Small Interfering