title: Congenital disorders of the thyroid: hypo/hyper.
abstract: This article summarizes the ontogenesis and genetics of the thyroid with regards to its possible congenital dysfunction and briefly refers to the roles of the mother-placenta-fetal unit, iodine effect, and organic and functional changes of the negative feedback mechanism, as well as maturity and illness, in some forms of congenital hypo- and hyperthyroidism. This article also describes the published literature and the authors' data on the clinical aspects of congenital hypothyroidism, on the alternating hypo- and hyperthyroidism in the neonatal period, and on neonatal hyperthyroidism.
authors.affiliation: Department of Pediatrics, Division of Endocrinology, St. Johns Hospital and United Hospitals of North-Buda, Buda Children's Hospital, 1023 Bolyai-u. 5-9, Budapest, Hungary. peter_f@budaigyk.hu
authors.forename: Ferenc
authors.initials: F
authors.lastname: Péter
authors.forename: Agota
authors.initials: A
authors.lastname: Muzsnai
mesh_terms: D003409:Congenital Hypothyroidism / Q000235:genetics* / Q000503:physiopathology*; D006801:Humans; D006980:Hyperthyroidism / Q000151:congenital / Q000235:genetics / Q000503:physiopathology; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000235:genetics / Q000503:physiopathology