title: Efficient and regioselective one-pot synthesis of 3-substituted and 3,5-disubstituted isoxazoles.
abstract: A series of 3-substituted and 3,5-disubstituted isoxazoles have been efficiently synthesized in moderate to excellent yields by the reaction of N-hydroxyl-4-toluenesulfonamide with alpha,beta-unsaturated aldehydes/ketones. This novel strategy is associated with readily available starting materials, mild conditions, high regioselectivity, and wide scope.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Department of Chemistry, Lanzhou University, Lanzhou 730000, PR China.
authors.forename: Shibing
authors.initials: S
authors.lastname: Tang
authors.forename: Jinmei
authors.initials: J
authors.lastname: He
authors.forename: Yongquan
authors.initials: Y
authors.lastname: Sun
authors.forename: Liuer
authors.initials: L
authors.lastname: He
authors.forename: Xuegong
authors.initials: X
authors.lastname: She
mesh_terms: D002384:Catalysis; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism; D013449:Sulfonamides / Q000737:chemistry*; D014050:Toluene / Q000031:analogs & derivatives* / Q000737:chemistry
chemical_list: D007555:Isoxazoles; C543538:N-hydroxyl-4-toluenesulfonamide; D013449:Sulfonamides; D014050:Toluene