Towards enzyme-like enantioselectivity in the gas phase: conformational control of selectivity in chiral macrocyclic dimers.
Conformational factors in self-assembled chiral tetraamide macrocycles control their gas-phase enantioselectivity towards the ethyl ester of naphthylalanine to levels typical of enzymes.
Fraschetti
Caterina
C
Dipartimento di Chimica e Tecnologie del Farmaco, Università di Roma La Sapienza, Rome, Italy.
Pierini
Marco
M
Villani
Claudio
C
Gasparrini
Francesco
F
Mortera
Stefano Levi
SL
Speranza
Maurizio
M
D000409:Alanine / Q000031:analogs & derivatives / Q000737:chemistry; D002384:Catalysis; D005740:Gases / Q000737:chemistry*; D006860:Hydrogen Bonding; D007700:Kinetics; D047028:Macrocyclic Compounds / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods; D013237:Stereoisomerism; D013816:Thermodynamics
D005740:Gases; D047028:Macrocyclic Compounds; D000409:Alanine