title: A fluorescence "turn-on" ensemble for acetylcholinesterase activity assay and inhibitor screening.
abstract: By making use of the aggregation-induced emission feature of compound 1 and the cascade reactions among acetylthiocholine iodide (ATC), AChE, and compound 2, a new fluorescence "turn-on" method is developed for AChE assay and inhibitor-screening.
authors.affiliation: Beijing National Laboratory for Molecular Sciences, Organic Solids Laboratory, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
authors.forename: Lihua
authors.initials: L
authors.lastname: Peng
authors.forename: Guanxin
authors.initials: G
authors.lastname: Zhang
authors.forename: Deqing
authors.initials: D
authors.lastname: Zhang
authors.forename: Junfeng
authors.initials: J
authors.lastname: Xiang
authors.forename: Rui
authors.initials: R
authors.lastname: Zhao
authors.forename: Yilin
authors.initials: Y
authors.lastname: Wang
authors.forename: Daoben
authors.initials: D
authors.lastname: Zhu
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism*; D000122:Acetylthiocholine / Q000031:analogs & derivatives / Q000737:chemistry; D001555:Benzene Derivatives / Q000737:chemistry; D002800:Cholinesterase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D005453:Fluorescence; D015394:Molecular Structure; D011758:Pyrroles / Q000737:chemistry
chemical_list: D001555:Benzene Derivatives; D002800:Cholinesterase Inhibitors; D011758:Pyrroles; C543539:acetylthiocholine iodide; D000122:Acetylthiocholine; D000110:Acetylcholinesterase