title: Three adducts of butenolide and apigenin glycoside from the leaves of Machilus japonica.
abstract: Chemical investigation of the EtOH extract of the leaves of Machilus japonica var. kusanoi resulted in the isolation of three compounds with a unique skeleton, i.e., apigenosylides A-C (4-6), together with five known flavonoid glycosides. Some of these compounds possess moderate inhibitory activity against alpha-glucosidase. The structures of the new compounds were elucidated on the basis of spectrometric analyses. They possess an unprecedented skeleton comprising the adduct of a butenolide moiety and apigenin glycoside linked via a 1,2-dioxane moiety.
authors.affiliation: College of Medicine, National Taiwan University, Taipei 10051, Taiwan, Republic of China. shoeilee@ntu.edu.tw
authors.forename: Shoei-Sheng
authors.initials: SS
authors.lastname: Lee
authors.forename: Yi-Shan
authors.initials: YS
authors.lastname: Lin
authors.forename: Chien-Kuang
authors.initials: CK
authors.lastname: Chen
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D047310:Apigenin / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001407:Bacillus / Q000201:enzymology; D065089:Glycoside Hydrolase Inhibitors; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013624:Taiwan
chemical_list: D065089:Glycoside Hydrolase Inhibitors; D006027:Glycosides; C543776:apigenosylide A; C543777:apigenosylide B; C543778:apigenosylide C; D047310:Apigenin; C004511:butenolide; D015107:4-Butyrolactone