title: Recent advances in the application of computational mechanics to the diagnosis and treatment of cardiovascular disease.
abstract: During the last 30 years, research into the pathogenesis and progression of cardiovascular disease has had to employ a multidisciplinary approach involving a wide range of subject areas, from molecular and cell biology to computational mechanics and experimental solid and fluid mechanics. In general, research was driven by the need to provide answers to questions of critical importance for disease management. Ongoing improvements in the spatial resolution of medical imaging equipment coupled to an exponential growth in the capacity, flexibility and speed of computational techniques have provided a valuable opportunity for numerical simulations and complex experimental techniques to make a contribution to improving the diagnosis and clinical management of many forms of cardiovascular disease. This paper contains a review of recent progress in the numerical simulation of cardiovascular mechanics, focusing on three particular areas: patient-specific modeling and the optimization of surgery in pediatric cardiology, evaluating the risk of rupture in aortic aneurysms, and noninvasive characterization of intraventricular flow in the management of heart failure.
authors.affiliation: Department of Mechanical and Aerospace Engineering, University of California, San Diego, California, USA.
authors.forename: Juan C
authors.initials: JC
authors.lastname: Del Alamo
authors.forename: Alison L
authors.initials: AL
authors.lastname: Marsden
authors.forename: Juan C
authors.initials: JC
authors.lastname: Lasheras
mesh_terms: D000783:Aneurysm / Q000503:physiopathology; D017542:Aneurysm, Ruptured; D001696:Biomechanical Phenomena; D002318:Cardiovascular Diseases / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy*; D003198:Computer Simulation; D003936:Diagnosis, Computer-Assisted; D015444:Exercise; D018729:Fontan Procedure; D006333:Heart Failure / Q000503:physiopathology; D006439:Hemodynamics; D006801:Humans; D008955:Models, Cardiovascular; D018570:Risk Assessment; D013813:Therapy, Computer-Assisted; D016277:Ventricular Function, Left