A synthetic furanone potentiates the effect of disinfectants on Salmonella in biofilm.
OBJECTIVE
To study a possible effect of a synthetic brominated furanone on biofilm formation and biofilm resistance to disinfectants in Salmonella enterica.


RESULTS
The effect of a synthetic furanone on biofilm formation of Salm. enterica serovar Agona and Salm. enterica serovar Typhimurium (11 strains of different origins) was evaluated in a microtiterplate assay. A significant reduction in biofilm build-up in microtiterplates by the furanone was observed for seven of the strains tested. Biofilms by two Salm. Agona feed factory strains and the effects on survival after exposures to disinfectants (hypochlorite and benzalkonium chloride) were assessed for both strains. Pretreatment with furanone significantly potentiated the effect of the two disinfectants for both strains.


CONCLUSIONS
The effect of disinfectants on Salmonella in biofilm was significantly enhanced when the biofilm was grown in the presence of furanone. This was probably because of an effect on biofilm architecture, composition and in some cases also biofilm build-up.


CONCLUSIONS
The present study gives valuable new knowledge in the fight against Salmonella biofilm in the environment because of the potentiated effect of conventional disinfectants.
Vestby
L K
LK
 Section of Bacteriology, National Veterinary Institute, Oslo, Norway.
Lönn-Stensrud
J
J
 Faculty of Dentistry, Department of Oral Biology, University of Oslo, Oslo, Norway.
Møretrø
T
T
 Nofima mat, Aas, Norway.
Langsrud
S
S
 Nofima mat, Aas, Norway.
Aamdal-Scheie
A
A
 Faculty of Dentistry, Department of Oral Biology, University of Oslo, Oslo, Norway.
Benneche
T
T
 Faculty of Chemistry, Department of Chemistry, University of Oslo, Oslo, Norway.
Nesse
L L
LL
 Section of Bacteriology, National Veterinary Institute, Oslo, Norway.
D018441:Biofilms / Q000187:drug effects*; D004202:Disinfectants / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D005663:Furans / Q000494:pharmacology*; D053038:Quorum Sensing / Q000187:drug effects; D019779:Salmonella enterica / Q000187:drug effects*
D004202:Disinfectants; D005663:Furans