title: Acute psychiatric illness in a young woman: an unusual form of encephalitis.
abstract: A 21-year-old woman was admitted to hospital with a diagnosis of acute psychotic mania, but developed, over approximately 6 weeks, seizures, delirium, catatonia, movement disorder and autonomic dysfunction. She was found to have antibodies to N-methyl-D-aspartate (NMDA) NR1-NR2 receptors in both serum and cerebrospinal fluid, consistent with anti-NMDA-receptor encephalitis, a severe, potentially lethal but treatment-responsive encephalitis often associated with ovarian tumour. With aggressive immunotherapy and bilateral oophorectomy, she recovered over a period of 14 months from her initial presentation. No ovarian tumour was identified.
authors.affiliation: Department of Neurology, Royal Prince Alfred Hospital, Sydney, NSW. drksharp@bigpond.net.au
authors.forename: Kaitlyn L
authors.initials: KL
authors.lastname: Parratt
authors.forename: Martin
authors.initials: M
authors.lastname: Allan
authors.forename: Simon J G
authors.initials: SJ
authors.lastname: Lewis
authors.forename: Josep
authors.initials: J
authors.lastname: Dalmau
authors.forename: Gabor M
authors.initials: GM
authors.lastname: Halmagyi
authors.forename: Judith M
authors.initials: JM
authors.lastname: Spies
mesh_terms: D000208:Acute Disease; D000906:Antibodies / Q000097:blood / Q000134:cerebrospinal fluid; D001714:Bipolar Disorder / Q000175:diagnosis / Q000209:etiology*; D003937:Diagnosis, Differential; D004569:Electroencephalography; D004660:Encephalitis / Q000150:complications* / Q000175:diagnosis / Q000276:immunology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D016194:Receptors, N-Methyl-D-Aspartate / Q000276:immunology / Q000378:metabolism; D014057:Tomography, X-Ray Computed; D055815:Young Adult
chemical_list: D000906:Antibodies; D016194:Receptors, N-Methyl-D-Aspartate