Growth factors and corneal epithelial wound healing.
In this article, we briefly review recent findings in the effects of growth factors including the EGF family, KGF, HGF, IGF, insulin, and TGF-beta on corneal epithelial wound healing. We discuss the essential role of EGFR in inter-receptor cross-talk in response to wounding in corneal epithelium and bring forward a concept of "alarmins" to the field of wound healing research.
Yu
Fu-Shin X
FS
Kresge Eye Institute, Departments of Ophthalmology and Anatomy and Cell Biology, Wayne State University School of Medicine, 4717 St. Antoine Blvd., Detroit, MI, 48201, USA. fyu@med.wayne.edu
Yin
Jia
J
Xu
Keping
K
Huang
Jenny
J
D000818:Animals; D003316:Corneal Diseases / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D019573:Epithelium, Corneal / Q000503:physiopathology*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000145:classification / Q000502:physiology*; D008954:Models, Biological; D015398:Signal Transduction / Q000502:physiology; D014945:Wound Healing / Q000502:physiology*
D036341:Intercellular Signaling Peptides and Proteins