title: Efficacy of combined 0.05% cyclosporine and 1% methylprednisolone treatment for chronic dry eye.
abstract: OBJECTIVE
  To compare the efficacy of topical cyclosporine 0.05% (tCsA) and combined treatment with 1% methylprednisolone acetate for the treatment of moderate-to-severe chronic dry eye.
  
  
  METHODS
  Forty-four patients with moderate-to-severe dry eye who had not responded to conventional treatment were treated with tCsA for 3 months. Twenty-one subjects (Group 1) were treated with 1% methyl prednisolone acetate and tCsA for the initial 3 weeks, and treated with tCsA only thereafter, and 23 subjects (Group 2) were treated with tCsA only. Symptom scores, tear break-up time (TBUT), Schirmer score, and corneal and conjunctival fluorescein staining were evaluated before and at 1, 2, and 3 months after treatment. Proinflammatory factors, interleukin-6 (IL-6), and interleukin-8 (IL-8) tear concentration were measured before treatment and at 3 months.
  
  
  RESULTS
  Symptom scores, Schirmer scores, TBUT score, corneal fluorescein, and conjunctival staining showed significant improvement at 1 month compared to baseline in group 1 (all P < 0.001), and all the same but few exceptions in group 2 (P = 0.002 on Schirmer, P = 0.267 on cornea stating). In symptom scores, Schirmer scores, and corneal staining, greater improvements were observed for group 1 at 1 month compared to group 2 (P < 0.001, P = 0.039, P = 0.01, respectively). However, in TBUT score and conjunctival staining, there were no between-group differences (P = 0.277, P = 0.254, respectively). The time interval from treatment initiation to symptom relief was shorter for group 1 than group 2. Both groups showed decreased tear IL-6 and IL-8 concentrations at 3 months compared to baseline levels (P < 0.05). However, no between-group differences were noted in mean concentrations of IL-6 and IL-8 at baseline and at 3 months.
  
  
  CONCLUSIONS
  Treatment with tCsA appears to be safe and effective in moderate-to-severe chronic dry eye. Additional short-term use of a topical steroid had the benefit of providing faster symptom relief and improvement of ocular sign without serious complications.
authors.affiliation: Vision Research Institute, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Yeo-jue
authors.initials: YJ
authors.lastname: Byun
authors.forename: Tae-im
authors.initials: TI
authors.lastname: Kim
authors.forename: Sang Min
authors.initials: SM
authors.lastname: Kwon
authors.forename: Kyung Yul
authors.initials: KY
authors.lastname: Seo
authors.forename: Sun Woong
authors.initials: SW
authors.lastname: Kim
authors.forename: Eung Kweon
authors.initials: EK
authors.lastname: Kim
authors.forename: Woo Chan
authors.initials: WC
authors.lastname: Park
mesh_terms: D002908:Chronic Disease; D016572:Cyclosporine / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D015352:Dry Eye Syndromes / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D015590:Fluorophotometry; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D015850:Interleukin-6 / Q000378:metabolism; D016209:Interleukin-8 / Q000378:metabolism; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage*; D008875:Middle Aged; D009883:Ophthalmic Solutions / Q000008:administration & dosage; D013666:Tears / Q000502:physiology; D016896:Treatment Outcome
chemical_list: D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D015850:Interleukin-6; D016209:Interleukin-8; D009883:Ophthalmic Solutions; D016572:Cyclosporine; D008775:Methylprednisolone