The effects of lifestyle modification on a new oxidized low-density lipoprotein marker, serum amyloid A-LDL, in subjects with primary lipid disorder.
BACKGROUND
Lifestyle modification improves the pathophysiology of lipid disorder, leading to the development of cardiovascular disease (CVD). While oxidized low-density lipoprotein (oxLDL) may be involved in this mechanism, various oxLDL measurements have recently been developed and therefore further detailed studies are called for in this area. Our aim was to investigate the effects of lifestyle modification on serum amyloid A-LDL (SAA-LDL), a new oxLDL, in subjects with primary lipid disorder.


METHODS
A total of 141 asymptomatic subjects (women/men=100/41, mean age 57.6 years) with>or=1 lipid abnormality (circulating high levels of low-density lipoprotein cholesterol [LDL-C] and triglyceride [TG] or low levels of high-density lipoprotein cholesterol [HDL-C]), who completed a 6-month lifestyle modification program in combination with diet and exercise, were analyzed. In the pre- and post-intervention, the metabolic variables including SAA-LDL were assessed.


RESULTS
During our intervention, the body mass index, blood pressure, LDL-C, TG, glucose and SAA-LDL significantly decreased, while HDL-C significantly increased. Multiple regression analysis revealed that the change levels of TG (positive) and HDL-C (inverse) were significantly and independently correlated to those of SAA-LDL.


CONCLUSIONS
These results suggest that SAA-LDL may contribute to the link between lipid disorder and the development of CVD, and that the application of SAA-LDL measurements may be useful for the assessment of the risk of CVD as a biochemical marker.
Kotani
Kazuhiko
K
Department of Clinical Laboratory Medicine, Jichi Medical University, Tochigi 329-0498, Japan. kazukotani@jichi.ac.jp
Koibuchi
Harumi
H
Yamada
Toshiyuki
T
Taniguchi
Nobuyuki
N
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000150:complications / Q000517:prevention & control; D005260:Female; D006801:Humans; D008019:Life Style; D052439:Lipid Metabolism Disorders / Q000150:complications / Q000378:metabolism* / Q000503:physiopathology; D008077:Lipoproteins, LDL / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D000685:Serum Amyloid A Protein / Q000378:metabolism*
D015415:Biomarkers; D008077:Lipoproteins, LDL; D000685:Serum Amyloid A Protein; C099252:oxidized low density lipoprotein