Prenylated flavones from Artocarpus lanceifolius and their cytotoxic properties against P-388 cells.
New prenylated flavones, artoindonesianins Z-4 and Z-5, together with four known prenylated flavones, artonin E, 12-hydroxyartonin E, artobiloxanthone, and cycloartobiloxanthone, have been isolated from the methanol extract of the tree bark of Artocarpus lanceifolius. The structures of these compounds were determined on the basis of spectroscopic data, including UV, IR, 1D and 2D NMR, and mass spectra. The cytotoxic effect of the isolated compounds against murine leukemia P-388 cells is described.
Musthapa
Iqbal
I
Department of Chemistry, Institut Teknologi Bandung, Jalan Ganesha 10, Bandung 40132, Indonesia.
Latip
Jalifah
J
Takayama
Hiromitsu
H
Juliawaty
Lia D
LD
Hakim
Euis H
EH
Syah
Yana M
YM
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D031622:Artocarpus / Q000737:chemistry*; D045744:Cell Line, Tumor; D047309:Flavones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D007941:Leukemia P388 / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D000432:Methanol; D051379:Mice; D024301:Plant Bark / Q000737:chemistry; D054876:Prenylation; D012997:Solvents; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared
D000972:Antineoplastic Agents, Phytogenic; D047309:Flavones; D012997:Solvents; C543769:artoindonesianin Z-4; C543770:artoindonesianin Z-5; D000432:Methanol