title: Stereocontrolled synthesis of oxaspirobicycles via Prins-pinacol annulation.
abstract: We have developed the stereoselective synthesis of 2-oxaspiro[m,n]alkane derivatives using the Prins-pinacol annulation of alkene diols with a wide range of aliphatic or aromatic aldehydes and ketones. This approach was further applied for the synthesis of oxatricyclic ring system.
authors.affiliation: Center for Chemoinformatics Research, Life Science Division, Korea Institute of Science and Technology (KIST), Seoul, 136-791, Republic of Korea.
authors.forename: Satish N
authors.initials: SN
authors.lastname: Chavre
authors.forename: Punna Reddy
authors.initials: PR
authors.lastname: Ullapu
authors.forename: Sun-Joon
authors.initials: SJ
authors.lastname: Min
authors.forename: Jae Kyun
authors.initials: JK
authors.lastname: Lee
authors.forename: Ae Nim
authors.initials: AN
authors.lastname: Pae
authors.forename: Youseung
authors.initials: Y
authors.lastname: Kim
authors.forename: Yong Seo
authors.initials: YS
authors.lastname: Cho
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D000473:Alkanes / Q000138:chemical synthesis* / Q000737:chemistry; D000475:Alkenes / Q000737:chemistry; D003500:Cyclization; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010100:Oxygen / Q000737:chemistry; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000438:Alcohols; D000473:Alkanes; D000475:Alkenes; D006571:Heterocyclic Compounds; D013141:Spiro Compounds; D010100:Oxygen