[Tubercular inflammation of cervical lymph nodes with a colliquative tuberculosis focus--a case study].
Cutaneous tuberculosis is a specific form of tuberculosis, with various clinical pictures and resulting from either endo- or exogenous way of infection, immunological mechanisms and unfavourable conditions for mycobacterium development. The atypical course and symptoms of the disease may cause difficulties in obtaining proper diagnosis and, in consequence, result in delayed onset of appropriate treatment. When diagnosing cutaneous tuberculosis, a broad spectrum of differential diagnoses should be applied, taking into account other diseases, such as, among others, leishmaniasis, actinomycosis, leprosy or deep mycoses. In this report, a case of lymph node tuberculosis and of colliquative tuberculosis of the skin, at first erroneously diagnosed as actinomycosis, complicated by multiform erythema. In the reported case, no tuberculous bacilli were identified in bacteriological evaluations of bioptates, collected from the skin changes. The final diagnosis of the disease was determined by the presence of specific granulation tissue in the last of performed histopathological studies, as well as by hypersensitivity to tuberculin and the presence of mycobacterial DNA in PCR evaluation. According to the authors, in case of clinically suspected cutaneous tuberculosis, repeated (several) histopathological studies of samples from observed changes seem to be fairly justified. The results of histopathological studies should be completed by one of the methods of oligomycobacterial material evaluation, e.g. by identification of mycobacterial genetic material by means of nucleic acid amplification in the PCR method.
Owczarek
Witold
W
Klinika Dermatologii Centralnego Szpitala Klinicznego MIN, Wojskowy Instytut Medyczny w Warszawie, Warszawa. witold.owczarek@dermedicus.pl
Targowski
Tomasz
T
Łebkowska
Katarzyna
K
Paluchowska
Elwira
E
D000196:Actinomycosis / Q000175:diagnosis / Q000188:drug therapy; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D003937:Diagnosis, Differential; D004891:Erythema Induratum / Q000175:diagnosis / Q000188:drug therapy; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000382:microbiology; D008969:Molecular Sequence Data; D009169:Mycobacterium tuberculosis / Q000302:isolation & purification*; D009333:Neck; D016133:Polymerase Chain Reaction / Q000379:methods; D014382:Tuberculosis, Cutaneous / Q000175:diagnosis* / Q000188:drug therapy* / Q000382:microbiology; D014388:Tuberculosis, Lymph Node / Q000175:diagnosis* / Q000188:drug therapy* / Q000382:microbiology
D000900:Anti-Bacterial Agents