title: Abnormally high body mass index and tobacco use are associated with poor sperm quality as revealed by reduced sperm binding to hyaluronan-coated slides.
abstract: Responses on a lifestyle questionnaire were correlated with results from traditional semen analysis and a newer functional sperm assay, namely, the ability of sperm to bind to a hyaluronan-coated slide. Increased percent normal morphology and motile sperm concentration were positively correlated with increased HA-binding score, whereas tobacco use (either current or previous history) and abnormally high body mass index were associated with lower binding scores.
authors.affiliation: Center for Reproductive Biology of Indiana, Indianapolis, Indiana 46280, USA. cwegner@reproductiveindiana.com
authors.forename: Carole C
authors.initials: CC
authors.lastname: Wegner
authors.forename: Alicia L
authors.initials: AL
authors.lastname: Clifford
authors.forename: Patricia M
authors.initials: PM
authors.lastname: Jilbert
authors.forename: Michael A
authors.initials: MA
authors.lastname: Henry
authors.forename: William L
authors.initials: WL
authors.lastname: Gentry
mesh_terms: D001665:Binding Sites; D015992:Body Mass Index; D006801:Humans; D006820:Hyaluronic Acid / Q000378:metabolism*; D007248:Infertility, Male / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D008019:Life Style; D008297:Male; D009765:Obesity / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D055101:Semen Analysis / Q000379:methods*; D012907:Smoking / Q000009:adverse effects*; D013076:Sperm Count; D013081:Sperm Motility; D013094:Spermatozoa / Q000378:metabolism* / Q000473:pathology; D011795:Surveys and Questionnaires
chemical_list: D006820:Hyaluronic Acid