Abnormal parieto-motor connectivity in Tuberous Sclerosis Complex.
Abnormal connectivity might be involved in the pathophysiology of Tuberous Sclerosis Complex (TSC). We used twin-coil Transcranial Magnetic Stimulation protocol to investigate connectivity between posterior parietal cortex (PPC) and motor cortex (M1) in TSC patients. In comparison with healthy subjects and TSC patients treated with antiepileptic drugs, non-medicated TSC patients exhibited abnormal excitability of PPC-M1 connection. Such altered connectivity might play a role in TSC epileptic phenotype.
D'Argenzio
Luigi
L
Paediatric Neurology and Psychiatry Unit, Neuroscience Department, Tor Vergata University, Rome, Italy. luigi.d.argenzio@uniroma2.it
Koch
Giacomo
G
Bombardieri
Roberta
R
Mori
Francesco
F
Moavero
Romina
R
Centonze
Diego
D
Curatolo
Paolo
P
D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D001931:Brain Mapping; D004558:Electric Stimulation; D004576:Electromyography; D019054:Evoked Potentials, Motor / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000503:physiopathology*; D009434:Neural Pathways / Q000503:physiopathology; D010296:Parietal Lobe / Q000503:physiopathology*; D012815:Signal Processing, Computer-Assisted; D050781:Transcranial Magnetic Stimulation; D014402:Tuberous Sclerosis / Q000503:physiopathology*