Exogenous leptin administration decreases sperm count and increases the fraction of abnormal sperm in adult rats.
Daily intraperitoneal injection of 5-30 microg/kg body weight of leptin for 42 days to adult rats decreases sperm count and increases the fraction of abnormal sperm.
Haron
Mohd Nizam
MN
Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia.
D'Souza
Urban J A
UJ
Jaafar
Hasnan
H
Zakaria
Rahimah
R
Singh
Harbindar Jeet
HJ
D000818:Animals; D007274:Injections, Intraperitoneal; D020738:Leptin / Q000008:administration & dosage*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D011994:Recombinant Proteins / Q000008:administration & dosage; D012671:Seminiferous Tubules / Q000187:drug effects / Q000473:pathology; D013076:Sperm Count; D013094:Spermatozoa / Q000187:drug effects* / Q000473:pathology; D013997:Time Factors
D020738:Leptin; D011994:Recombinant Proteins