title: Multiple IgG4-related sclerosing lesions in the maxillary sinus, parotid gland and nasal septum.
abstract: IgG4-related sclerosing disease is recognized as a distinct clinicopathological entity. It is well known that this disease can occur in the salivary, lacrimal and pituitary glands, in the head and neck region. The nasal cavity is an extremely rare site of involvement of IgG4-related sclerosing disease. Herein is reported a case of multiple IgG4-related sclerosing lesions in the maxillary sinus, parotid gland and nasal septum. A 73-year-old Japanese man presented with nasal obstruction and tumors of the right maxillary sinus and parotid gland were detected, after which resections of these tumors were performed. One year after the last surgery, he noted swelling of the nasal septum, and the tumor was resected. These three tumors had similar histopathology, such as conspicuous fibrosclerotic changes with dense lymphoplasmacytic infiltration and occasional obliterative phlebitis. Immunohistochemistry indicated abundant IgG4-positive plasma cell infiltration and high ratios of IgG4-positive/IgG-positive plasma cells (>70%) in all three lesions. The diagnosis of multiple IgG4-related sclerosing lesions was made. The present case suggests that IgG4-related sclerosing lesion can occur in the maxillary sinus and nasal septum, and represents an extension of the spectrum of IgG4-related sclerosing disease.
authors.affiliation: Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Shiga 520-2192, Japan. mitsuaki@belle.shiga-med.ac.jp
authors.forename: Mitsuaki
authors.initials: M
authors.lastname: Ishida
authors.forename: Machiko
authors.initials: M
authors.lastname: Hotta
authors.forename: Ryoji
authors.initials: R
authors.lastname: Kushima
authors.forename: Masayuki
authors.initials: M
authors.lastname: Shibayama
authors.forename: Takeshi
authors.initials: T
authors.lastname: Shimizu
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Okabe
mesh_terms: D000368:Aged; D003937:Diagnosis, Differential; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D008297:Male; D008443:Maxillary Sinus / Q000276:immunology / Q000473:pathology* / Q000601:surgery; D009300:Nasal Septum / Q000276:immunology / Q000473:pathology* / Q000601:surgery; D010306:Parotid Gland / Q000276:immunology / Q000473:pathology* / Q000601:surgery; D010950:Plasma Cells / Q000473:pathology; D012086:Reoperation; D012598:Sclerosis; D012793:Sialadenitis / Q000175:diagnosis; D012852:Sinusitis / Q000175:diagnosis; D016896:Treatment Outcome
chemical_list: D007074:Immunoglobulin G