title: Decreasing amputation rates in patients with diabetes-a population-based study.
abstract: OBJECTIVE
  To assess the changing rate of amputation in patients with diabetes over a 7-year period.
  
  
  METHODS
  All patients undergoing lower extremity amputation in Tayside, Scotland between 1 January 2000 and 31 December 2006 were identified. Temporal linkage of cases to the diabetes database was used to ascertain which amputations were in patients with diabetes.
  
  
  RESULTS
  The incidence of major amputations fell from 5.1 [95% confidence interval (CI) 3.8-6.4] to 2.9 (95% CI 1.9-3.8) per 1000 patients with diabetes (P < 0.05). There is a clear linear trend in the adjusted incidence of major amputation (P = 0.023 and 0.027 for age- and sex-adjusted, and duration- and sex-adjusted incidences, respectively). The adjusted incidence of total amputations followed decreased linear regression trend over the whole study period when adjusted for age and sex or diabetes duration and sex (P = 0.002).
  
  
  CONCLUSIONS
  There has been a significant reduction in the incidence of major lower extremity amputation in patients with diabetes over the 7-year period.
authors.affiliation: Ninewells Hospital and Medical School, Dundee, UK. cschofield@nhs.net
authors.forename: C J
authors.initials: CJ
authors.lastname: Schofield
authors.forename: N
authors.initials: N
authors.lastname: Yu
authors.forename: A S
authors.initials: AS
authors.lastname: Jain
authors.forename: G P
authors.initials: GP
authors.lastname: Leese
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000671:Amputation, Surgical / Q000706:statistics & numerical data*; D015331:Cohort Studies; D017719:Diabetic Foot / Q000453:epidemiology / Q000601:surgery*; D005260:Female; D005528:Foot / Q000601:surgery; D006801:Humans; D015994:Incidence; D007866:Leg / Q000601:surgery; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D012189:Retrospective Studies; D012307:Risk Factors; D012606:Scotland / Q000453:epidemiology