title: SmI(2)-mediated carbon-carbon bond fragmentation in alpha-aminomethyl malonates.
abstract: A new and efficient samarium diiodide-promoted carbon-carbon bond fragmentation reaction of alpha-aminomethyl malonates, taking place normally at room temperature and generating the corresponding deaminomethylation products in 74-94% yields, is reported. The presence of the amino group is necessary for the success of the current transformation.
authors.affiliation: The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xue Yuan Road, Beijing 100083, China.
authors.forename: Qiongfeng
authors.initials: Q
authors.lastname: Xu
authors.forename: Bin
authors.initials: B
authors.lastname: Cheng
authors.forename: Xinshan
authors.initials: X
authors.lastname: Ye
authors.forename: Hongbin
authors.initials: H
authors.lastname: Zhai
mesh_terms: D000606:Amino Sugars / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry*; D003500:Cyclization; D007454:Iodides / Q000737:chemistry*; D008314:Malonates / Q000737:chemistry*; D015394:Molecular Structure; D012493:Samarium / Q000737:chemistry*; D013329:Structure-Activity Relationship; D013696:Temperature
chemical_list: D000606:Amino Sugars; D007454:Iodides; D008314:Malonates; D012493:Samarium; D002244:Carbon; C409809:samarium diiodide