Prognostic factors for epileptic seizures in severe motor and intellectual disabilities syndrome (SMIDS)--a clinical and electroencephalographic study.
OBJECTIVE
The purpose of this study is to examine prognostic factors for seizures in 106 epileptic patients with SMIDS.


METHODS
One-hundred-six epileptic patients with SMIDS were the subjects of this study. The study group consisted of 60 male and 46 female patients. The ages ranged from 4 to 61 years. They were all followed up for more than 4 years in our residential facility hospital "Kobato Gakuen". Fourteen possible prognostic factors were investigated statistically, and the validity is studied by factor analysis (principal component method).


RESULTS
Statistically significant poor prognostic factors for epileptic seizures in SMIDS were (1) status epilepticus; (2) multifocal spikes (MFS) or Diffuse spike and waves (DSW) on final EEG; (3) symptomatic generalized epilepsy; (4) MFS or DSW on first EEG; (5) multi-antiepileptic drugs; (6) postnatal etiology; and (7) short duration of institutional hospitalization. As a result of factor analysis, the following five factors are elucidated: (1) Age/Time Passage; (2) Status epilepticus/Etiology; (3) Epileptic syndrome/EEG; (4) intensive medical care; and (5) Severity of Disabilities/Gender.


CONCLUSIONS
Our findings indicate that intractability of epilepsy may be identified early in the course of the disease, even in SMIDS, and EEG and epileptic syndrome are the very important factors for predicting the seizure prognosis.
Matsumoto
Akiko
A
Department of Pediatric Neurology, Kobato Gakuen, Aichi Human Service Center, Aichi Prefecture, Japan. matsumoto@aichi-colony.jp
Miyazaki
Shuji
S
Hayakawa
Chiemi
C
Komori
Taku
T
Nakamura
Miho
M
Oshio
Atsushi
A
D000293:Adolescent; D000328:Adult; D001931:Brain Mapping; D002648:Child; D002675:Child, Preschool; D002658:Developmental Disabilities / Q000175:diagnosis*; D004569:Electroencephalography; D004827:Epilepsy / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008607:Intellectual Disability / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D009069:Movement Disorders / Q000175:diagnosis*; D018579:Patient Selection; D011379:Prognosis; D011788:Quality of Life; D012720:Severity of Illness Index; D013577:Syndrome