title: Practical syntheses of 4-fluoroprolines.
abstract: 4-Fluoroprolines are among the most useful nonnatural amino acids in chemical biology. Here, practical routes are reported for the synthesis of the 2S,4R, 2S,4S, and 2R,4S diastereomers of 4-fluoroproline. Each route starts with (2S,4R)-4-hydroxyproline, which is a prevalent component of collagen and hence readily available, and uses a fluoride salt to install the fluoro group. Hence, the routes provide process-scale access to these useful nonnatural amino acids.
authors.affiliation: THINQ Pharma, Natick, MA 01760, USA.
authors.forename: Mukund S
authors.initials: MS
authors.lastname: Chorghade
authors.forename: Debendra K
authors.initials: DK
authors.lastname: Mohapatra
authors.forename: Gokarneswar
authors.initials: G
authors.lastname: Sahoo
authors.forename: Mukund K
authors.initials: MK
authors.lastname: Gurjar
authors.forename: Manish V
authors.initials: MV
authors.lastname: Mandlecha
authors.forename: Nitin
authors.initials: N
authors.lastname: Bhoite
authors.forename: Santosh
authors.initials: S
authors.lastname: Moghe
authors.forename: Ronald T
authors.initials: RT
authors.lastname: Raines