title: [Two cases of Crimean-Congo haemorrhagic fever (CCHF) in two tourists in Senegal in 2004].
abstract: Two cases of Crimean-Congo haemorrhagic fever (CCHF) occurred in two French tourists during their visit in Senegal in November 2004. Febrile and hemorrhagic syndrome with ulorrhagia, petechiae, haematemesis, haematomas associated with biological signs of disseminated intramuscular coagulation were observed. For the first case who had a medical evacuation to France before diagnosis, Crimean-Congo virus infection was revealed by laboratory tests performed by the National Reference Center for Hemorrhagic Fevers (NRCHF, Institut Pasteur, Lyon) and secondly by the Centre de Référence OMS sur la Recherche des Arbovirus et des virus des Fièvres Hémorragiques (CRORA) in the Dakar Pasteur Institute (DPI). The second case diagnosed by the CRORA died after clinical deterioration with liver failure and severe haemorrhages. Healthcare workers and family members who had contact with tissue or blood from patients were followed up after the putative exposure either in France or in Senegal.
authors.affiliation: Institut Pasteur de Dakar, BP 220 Dakar, Sénégal. tall@pasteur.sn
authors.forename: A
authors.initials: A
authors.lastname: Tall
authors.forename: A A
authors.initials: AA
authors.lastname: Sall
authors.forename: O
authors.initials: O
authors.lastname: Faye
authors.forename: B
authors.initials: B
authors.lastname: Diatta
authors.forename: R
authors.initials: R
authors.lastname: Sylla
authors.forename: J
authors.initials: J
authors.lastname: Faye
authors.forename: P C
authors.initials: PC
authors.lastname: Faye
authors.forename: O
authors.initials: O
authors.lastname: Faye
authors.forename: A B
authors.initials: AB
authors.lastname: Ly
authors.forename: F D
authors.initials: FD
authors.lastname: Sarr
authors.forename: H
authors.initials: H
authors.lastname: Diab
authors.forename: M
authors.initials: M
authors.lastname: Diallo
mesh_terms: D000368:Aged; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D001096:Arachnid Vectors / Q000382:microbiology; D001717:Birds / Q000469:parasitology; D002417:Cattle / Q000469:parasitology; D005190:Family; D017809:Fatal Outcome; D005260:Female; D005602:France / Q000208:ethnology; D006041:Goats / Q000469:parasitology; D003225:Hemorrhagic Fever Virus, Crimean-Congo / Q000276:immunology / Q000302:isolation & purification; D006479:Hemorrhagic Fever, Crimean / Q000453:epidemiology* / Q000635:transmission; D006801:Humans; D008403:Mass Screening; D008875:Middle Aged; D016273:Occupational Exposure; D010564:Personnel, Hospital; D012675:Senegal; D012756:Sheep / Q000469:parasitology; D013984:Tick Infestations / Q000097:blood / Q000150:complications / Q000453:epidemiology / Q000382:microbiology / Q000662:veterinary; D013987:Ticks / Q000382:microbiology; D014195:Travel; D015047:Zoonoses
chemical_list: D000914:Antibodies, Viral