title: Synthesis and cytotoxicity studies of new cryptophycin analogues.
abstract: Two analogues of cryptophycin were synthesized and biologically evaluated for their in-vitro cytotoxicities against several solid tumors and leukemia cell lines. The results revealed that both analogues exhibited a broad range of cytotoxic activity with observed IC(50 )values in the muM-range, and compound 4 was more effective than compound 3 in most assays studied.
authors.affiliation: School of Pharmacy, Shanghai Jiaotong University, Shanghai, P.R. China.
authors.forename: Wen Lu
authors.initials: WL
authors.lastname: Liu
authors.forename: Jian Cun
authors.initials: JC
authors.lastname: Zhang
authors.forename: Fa Qin
authors.initials: FQ
authors.lastname: Jiang
authors.forename: Lei
authors.initials: L
authors.lastname: Fu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D047630:Depsipeptides / Q000138:chemical synthesis / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D020128:Inhibitory Concentration 50; D051379:Mice; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D047630:Depsipeptides; C088419:cryptophycin