title: [Biological characteristics of translocating bacteria during experimental otitis media].
abstract: OBJECTIVE
  To study dynamics of species composition, factors of pathogenicity and persistence, index of microbial load by bacteria translocating to tympanic cavity from nasal cavity.
  
  
  METHODS
  Translocation of bacteria was reproduced on the model of experimental staphylococcal purulent otitis media in 22 adult rabbits from "chinchilla" breed. Identification of translocating strains was performed by radioisotope label. Microflora of nasopharynx and middle ear was studied on day 4, 6, 10, 20, 30, and 180 after inoculation.
  
  
  RESULTS
  Translocating strains differed from nontranslocating by higher level of antilysozyme activity (> or =3 mcg/ml) and higher proportion of their microbial load in total index of microbial load of source biotope (> or =5%). During unfavorable course of otitis, increase of pathogenicity of strains-translocants in circumstances of microbial interaction was observed.
  
  
  CONCLUSIONS
  One of the mechanisms for the development of otitis media is translocation of indigenous bacteria and their associates to the inflammation site in middle ear where microbial interactions determine the outcome of infection. Results of experimental studies allowed to develop the method for prediction of otitis media course.
authors.forename: B Ia
authors.initials: BIa
authors.lastname: Usviatsov
authors.forename: V A
authors.initials: VA
authors.lastname: Dolgov
mesh_terms: D000818:Animals; D002682:Chinchilla; D004195:Disease Models, Animal; D004432:Ear, Middle / Q000382:microbiology*; D009113:Muramidase / Q000378:metabolism; D009304:Nasopharyngitis / Q000382:microbiology; D009305:Nasopharynx / Q000382:microbiology; D010035:Otitis Media, Suppurative / Q000382:microbiology*; D011817:Rabbits; D013203:Staphylococcal Infections / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000378:metabolism / Q000472:pathogenicity* / Q000502:physiology; D014774:Virulence
chemical_list: D009113:Muramidase