title: Computational reasoning across multiple models.
abstract: Computational support of clinical decisions frequently requires the integration of data in a variety of formats and from multiple sources and domains. Some impressive multiscale computational models of biological phenomena have been developed as part of the study of disease and healthcare systems. One can now contemplate harnessing these models arising from computational biology and using highly interconnected clinical data to support clinical decision-making. Indeed, understanding how to build computational systems able to reason across heterogeneous models and datasets is one of the major and perhaps foundational challenges of translational biomedical informatics. In this paper, the authors examine the use of multimodels (models composed of several daughter models) and explore three major research challenges to reasoning across multiple models: model selection, model composition, and computer aided model construction.
authors.affiliation: Centre for Health Informatics, University of New South Wales, Sydney, NSW 2052 Australia. guyt@unsw.edu.au
authors.forename: Guy
authors.initials: G
authors.lastname: Tsafnat
authors.forename: Enrico W
authors.initials: EW
authors.lastname: Coiera
mesh_terms: D019295:Computational Biology / Q000379:methods*; D017076:Computer-Aided Design; D003658:Decision Making, Computer-Assisted; D020000:Decision Support Systems, Clinical; D003920:Diabetes Mellitus / Q000628:therapy; D006801:Humans; D051188:Knowledge Bases; D008113:Liver Neoplasms / Q000628:therapy; D008954:Models, Biological; D011381:Programming Languages; D013813:Therapy, Computer-Assisted