title: Changes in white matter microstructure in patients with TLE and hippocampal sclerosis.
abstract: OBJECTIVE
  Patients with mesial temporal lobe epilepsy (TLE) due to hippocampal sclerosis (HS) often show ictal and interictal propagation of epileptiform EEG activity to the ipsilateral temporal neocortex, the ipsilateral frontal lobe or the contralateral hippocampus, although structural MRI only shows unilateral involvement of the hippocampal formation. We used whole-head diffusion Tensor Imaging (DTI) to delineate a network that facilitates propagation of interictal epileptiform and seizure activity in this patient group.
  
  
  METHODS
  Isotropic 2 mm DTI was performed at 3 Tesla in 12 patients with medically intractable left TLE due to HS and compared to 12 controls. Whole-brain maps of fractional anisotropy (FA) were compared using a voxel based t-test to search for regions affected in patients with HS. This preliminary analysis was complementary to a set of anatomically guided region of interest (ROI) analyses that were manually defined on each individual's FA map.
  
  
  RESULTS
  Left HS patients showed FA decreases in the temporal lobe white matter bilaterally, the ipsilateral frontal lobe white matter (WM) and in the genu and trunk of the corpus callosum. ROI analysis identified a significant FA decrease in left HS subjects in the affected hippocampus, WM of the ipsilateral parahippocampal gyrus and the genu and trunk of the corpus callosum.
  
  
  CONCLUSIONS
  WM alterations occur bilaterally in the temporal lobe and in the ipsilateral superior frontal gyrus in left HS. The etiology and significance of these changes are unclear but the role of these regions in epileptogenesis and for pathways of epileptic spread should be further investigated.
authors.affiliation: Department of Neurology, Philipps-University, Marburg, Germany. knake@staff.uni-marburg.de
authors.forename: Susanne
authors.initials: S
authors.lastname: Knake
authors.forename: David H
authors.initials: DH
authors.lastname: Salat
authors.forename: Eric
authors.initials: E
authors.lastname: Halgren
authors.forename: Mark A
authors.initials: MA
authors.lastname: Halko
authors.forename: Douglas N
authors.initials: DN
authors.lastname: Greve
authors.forename: P Ellen
authors.initials: PE
authors.lastname: Grant
mesh_terms: D000328:Adult; D016880:Anisotropy; D001921:Brain / Q000473:pathology* / Q000648:ultrastructure; D001931:Brain Mapping; D003337:Corpus Callosum / Q000473:pathology / Q000648:ultrastructure; D038524:Diffusion Magnetic Resonance Imaging; D004569:Electroencephalography; D004833:Epilepsy, Temporal Lobe / Q000473:pathology*; D005260:Female; D006624:Hippocampus / Q000473:pathology* / Q000648:ultrastructure; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D012598:Sclerosis; D055815:Young Adult