title: [Risk factors for renal dysfunction after total hip arthroplasty].
abstract: BACKGROUND
  Postoperative renal dysfunction (PRD) is well-documented after cardiovascular surgery but there are only limited available data concerning major orthopedic surgery, although patients may have several risk factors prone to impair renal function. We designed an epidemiologic prospective study to assess the incidence of PRD after total hip arthroplasty (THA) and to determine risk factors.
  
  
  METHODS
  Were included in the study 755 patients scheduled for THA in a single centre, over a 14 months period. Thirty-one demographic, clinical and biological parameters were collected for each patient. PRD was defined by a value of glomerular filtration, determined by the Cockroft and Gault formula<or=60 ml/min per 1.73 m2, on the seventh postoperative day. Risk factors were determined by univariate and then multivariate analyses using a linear regression model.
  
  
  RESULTS
  Pre- and postoperatively (POD7), respectively 22.4% and 31.4% of the patients, had a creatinine clearance less than 60 ml/min per 1.73 m2. Univariate analysis documented age, ASA score, diabetes mellitus, chronic hypertension, the use of diuretics and NSAID, anemia, and an increased value of plasma urea as risk factors. Risk factors documented by multivariate analysis were: preoperative creatinine clearance less than 60 ml/min per 1.73 m2, (OR: 5.8, 95% confidence interval: [1.6-8.1], p=0.0006), preoperative plasma urea greater than 7.49 mmol/l (2.1 [1.4-11.1], p=0.04), age above 70 years (1.8 [1.1-4.3], p=0.02), and duration of NSAID's treatment beyond 5 days (3.2 [1.4-7.1], p=0.02).
  
  
  CONCLUSIONS
  PRD is common after THA and is prone to develop in aged patients with comorbidities. Duration of NSAID's administration should be limited in those patients.
authors.affiliation: Département d'anesthésie-réanimation chirurgicale, polyclinique Sévigné, 3, rue du Chêne-Germain, 35510 Cesson-Sévigné, France. christophe.aveline@anesthesie-sevigne.com
authors.forename: C
authors.initials: C
authors.lastname: Aveline
authors.forename: A
authors.initials: A
authors.lastname: Leroux
authors.forename: P
authors.initials: P
authors.lastname: Vautier
authors.forename: F
authors.initials: F
authors.lastname: Cognet
authors.forename: H
authors.initials: H
authors.lastname: Le Hetet
authors.forename: F
authors.initials: F
authors.lastname: Bonnet
mesh_terms: D058186:Acute Kidney Injury / Q000453:epidemiology*; D000367:Age Factors; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000627:therapeutic use; D019644:Arthroplasty, Replacement, Hip; D015897:Comorbidity; D003404:Creatinine / Q000097:blood; D003920:Diabetes Mellitus / Q000453:epidemiology; D004232:Diuretics / Q000627:therapeutic use; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology*; D011446:Prospective Studies; D012307:Risk Factors; D014508:Urea / Q000097:blood
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000959:Antihypertensive Agents; D004232:Diuretics; D014508:Urea; D003404:Creatinine