RISC hitches onto endosome trafficking.
The RNA-induced silencing complex (RISC) downregulates expression of the genes targeted by RNA-silencing pathways. But formation and turnover of the RISC complex itself is tightly regulated and requires endosomal membranes.
Siomi
Haruhiko
H
Siomi
Mikiko C
MC
D000818:Animals; D029721:Drosophila Proteins / Q000378:metabolism; D004331:Drosophila melanogaster / Q000166:cytology / Q000378:metabolism; D011992:Endosomes / Q000378:metabolism* / Q000648:ultrastructure; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism; D008954:Models, Biological; D021381:Protein Transport; D034741:RNA, Small Interfering / Q000378:metabolism; D034743:RNA-Induced Silencing Complex / Q000378:metabolism*
D029721:Drosophila Proteins; D035683:MicroRNAs; D034741:RNA, Small Interfering; D034743:RNA-Induced Silencing Complex