title: Acetaminophen-induced acute pancreatitis. A case report.
abstract: BACKGROUND
  Drug-induced acute pancreatitis is rare but should not be overlooked in a patient who presents with idiopathic acute pancreatitis. More than 100 drugs have been implicated in causing the disease: acetaminophen has been associated with acute pancreatitis in cases where there has been an overdose of drugs; however, the frequency is rare.
  
  
  METHODS
  We report the case of a 35-year-old woman who presented with acute pancreatitis and severe metabolic acidosis after overdosing on a drug containing acetaminophen. She improved dramatically after intensive care; however, she showed recurrent episodes after re-overdosing on the same drug. With her self re-challenge test, she was diagnosed as having acetaminophen-induced pancreatitis and metabolic acidosis. A review of the relevant literature is also presented.
  
  
  CONCLUSIONS
  Drug-induced acute pancreatitis is often challenging for clinicians and a detailed mechanism is unknown. It is very important to rule out drug-induced pancreatitis when treating pancreatitis with an unknown etiology.
authors.affiliation: Department of Gastroenterology, National Hospital Organization, Beppu Medical Center, Beppu, Japan. igaras@intmed3.med.kyushu-u.ac.jp
authors.forename: Hisato
authors.initials: H
authors.lastname: Igarashi
authors.forename: Tetsuhide
authors.initials: T
authors.lastname: Ito
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yoshinaga
authors.forename: Takamasa
authors.initials: T
authors.lastname: Oono
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Sakai
authors.forename: Ryoichi
authors.initials: R
authors.lastname: Takayanagi
mesh_terms: D000082:Acetaminophen / Q000009:adverse effects*; D000138:Acidosis / Q000175:diagnosis / Q000209:etiology; D000328:Adult; D062787:Drug Overdose / Q000150:complications / Q000175:diagnosis; D005260:Female; D006801:Humans; D010195:Pancreatitis / Q000139:chemically induced*
chemical_list: D000082:Acetaminophen