title: Inhibitors of osteoclast formation from rhizomes of Cibotium barometz.
abstract: Eight compounds (1-8) were isolated from a methanol extract of Cibotium barometz rhizomes including two new furan derivatives, cibotiumbarosides A (1) and B (2), and a new glycoglycerolipid, cibotiglycerol (4). Their structures were elucidated by chemical and spectroscopic methods. Compounds 2-5 each showed inhibition of osteoclast formation with no affect on BMM cell viability.
authors.affiliation: Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi, Vietnam.
authors.forename: Nguyen Xuan
authors.initials: NX
authors.lastname: Cuong
authors.forename: Chau Van
authors.initials: CV
authors.lastname: Minh
authors.forename: Phan Van
authors.initials: PV
authors.lastname: Kiem
authors.forename: Hoang Thanh
authors.initials: HT
authors.lastname: Huong
authors.forename: Ninh Khac
authors.initials: NK
authors.lastname: Ban
authors.forename: Nguyen Xuan
authors.initials: NX
authors.lastname: Nhiem
authors.forename: Nguyen Huu
authors.initials: NH
authors.lastname: Tung
authors.forename: Ji-Won
authors.initials: JW
authors.lastname: Jung
authors.forename: Hyun-Ju
authors.initials: HJ
authors.lastname: Kim
authors.forename: Shin-Yoon
authors.initials: SY
authors.lastname: Kim
authors.forename: Jeong Ah
authors.initials: JA
authors.lastname: Kim
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Kim
mesh_terms: D000818:Animals; D029624:Ferns / Q000737:chemistry*; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006017:Glycolipids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010010:Osteoclasts / Q000187:drug effects*; D027343:Rhizome / Q000737:chemistry; D014744:Vietnam
chemical_list: D005663:Furans; D006017:Glycolipids; D006027:Glycosides; C544365:cibotiglycerol; C544363:cibotiumbaroside A; C544364:cibotiumbaroside B; C015903:glycerolglycolipids