title: Dietary intervention with AHP, a functional formula diet, improves both serum and hepatic lipids profile in dyslipidemia mice.
abstract: Aurricularia aurricula, hawthorn (Crataegus pinnatifida), and Pueraria radix are well known for both traditional food and folk medicine. Each of the above 3 plants possesses a distinct pathway contributing to treat dyslipidemia. To develop a health-promoting diet against dyslipidemia, the polysaccharides from A. aurricula, polyphenol from hawthorn, and P. radix were combined to postulate as a functional formula diet (AHP) in the present study and its pharmaceutical effects and underlying mechanisms were elucidated in vivo. The dyslipidemia model associated with fatty liver was induced by cholesterol-enriched diet (CED) for up to 12 wk in male ICR mice. Mice were randomly divided into 5 groups, that is, regular diet (RD), CED, Xuezhikang treatment (positive control group, PG), low and high (150 or 450 mg/kg/d) of AHP treatment groups. Compared with the CED group, AHP groups maintained lipid profiles through lowering serum total cholesterol (TC) and low-density lipoprotein-cholesterol (LDL-C), inhibiting the accumulation of hepatic TC and triglyceride (TG). AHP could also improve both serum and hepatic biochemical activity profiles including antioxidant status, serum nitric oxide (NO), and hepatic 3-hydroxy-3-methylglutary CoA (HMG-CoA) reductase levels. Hepatic histopathological examinations showed markedly decreased fatty deposits in the liver of AHP-treated mice, illustrating the ability to reverse a condition of fatty liver. Our study indicated that this functional formula diet would be a potent alternative as a health-promoting diet, simultaneously targeting on the complexity and redundancy of dyslipidemia.
authors.affiliation: College of Food Science and Nutritional Engineering, China Agricultural Univ., Beijing, China.
authors.forename: Yangchao
authors.initials: Y
authors.lastname: Luo
authors.forename: Gang
authors.initials: G
authors.lastname: Chen
authors.forename: Bo
authors.initials: B
authors.lastname: Li
authors.forename: Baoping
authors.initials: B
authors.lastname: Ji
authors.forename: Zhenlei
authors.initials: Z
authors.lastname: Xiao
authors.forename: Guo
authors.initials: G
authors.lastname: Yi
authors.forename: Fang
authors.initials: F
authors.lastname: Tian
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D000975:Antioxidants / Q000032:analysis; D001487:Basidiomycota / Q000737:chemistry*; D001835:Body Weight; D020355:Cholates / Q000008:administration & dosage; D002784:Cholesterol / Q000008:administration & dosage / Q000032:analysis / Q000097:blood; D045424:Complex Mixtures / Q000737:chemistry / Q000627:therapeutic use; D027825:Crataegus / Q000737:chemistry; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000627:therapeutic use*; D050171:Dyslipidemias / Q000139:chemically induced / Q000188:drug therapy*; D005234:Fatty Liver / Q000517:prevention & control; D006903:Hydroxymethylglutaryl CoA Reductases / Q000378:metabolism; D008055:Lipids / Q000032:analysis* / Q000097:blood*; D008099:Liver / Q000737:chemistry* / Q000378:metabolism / Q000473:pathology; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008519:Medicine, Traditional; D051379:Mice; D009569:Nitric Oxide / Q000097:blood; D009929:Organ Size; D010936:Plant Extracts / Q000737:chemistry / Q000627:therapeutic use*; D029908:Pueraria; D011897:Random Allocation; D013482:Superoxide Dismutase / Q000097:blood
chemical_list: D000975:Antioxidants; D020355:Cholates; D045424:Complex Mixtures; D004365:Drugs, Chinese Herbal; D008055:Lipids; D010936:Plant Extracts; C442842:plant extract, Puerariae Radix; C496822:xuezhikang; D009569:Nitric Oxide; D008315:Malondialdehyde; C007145:crataegus extract; D002784:Cholesterol; D006903:Hydroxymethylglutaryl CoA Reductases; D013482:Superoxide Dismutase