Facile entry into triazole fused heterocycles via sulfamidate derived azido-alkynes.
Direct synthesis of condensed triazoles from diverse sulfamidates by ring opening of sulfamidates with sodium azide followed by one-pot propargylation and cycloaddition furnished title compounds. The methodology in general has been demonstrated on diverse sulfamidates derived from amino acids, amino acid derivatives, and carbohydrates to obtain diverse triazole fused scaffolds. In one example, a condensed triazole containing amino acid has been synthesized by ring opening of a sulfamidate derivative with propargyl amine.
Sai Sudhir
V
V
Department of Organic Chemistry, Indian Institute of Science, Bangalore-560012, Karnataka, India.
Phani Kumar
N Y
NY
Nasir Baig
R B
RB
Chandrasekaran
Srinivasan
S
D000480:Alkynes / Q000737:chemistry*; D001386:Azides / Q000737:chemistry*; D003500:Cyclization; D008968:Molecular Conformation; D013237:Stereoisomerism; D013451:Sulfonic Acids / Q000737:chemistry*; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry
D000480:Alkynes; D001386:Azides; D013451:Sulfonic Acids; D014230:Triazoles