title: Evolution of ribozymes in an RNA world.
abstract: Ribozymes (catalytic RNAs) were the center of a presumed RNA world in the early origin of life. In this issue, Lau and Unrau show evidence that an RNA world could have used a similar evolutionary pathway as most proteins do.
authors.affiliation: Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, 92093, USA. ufmuller@ucsd.edu
authors.forename: Ulrich F
authors.initials: UF
authors.lastname: Müller
mesh_terms: D019143:Evolution, Molecular; D006151:Guanosine / Q000031:analogs & derivatives / Q000737:chemistry; D009711:Nucleotides / Q000096:biosynthesis; D016337:RNA, Catalytic / Q000737:chemistry / Q000378:metabolism*; D012267:Ribosemonophosphates / Q000737:chemistry; D013872:Thionucleosides / Q000737:chemistry
chemical_list: D009711:Nucleotides; D016337:RNA, Catalytic; D012267:Ribosemonophosphates; D013872:Thionucleosides; D006151:Guanosine; C031626:ribose-5-phosphate; C005783:6-thioguanosine