title: Electrospray-ionization mass spectrometry study of cyclodextrin complexes with A007 prodrugs.
abstract: Electrospray-ionization mass spectrometric (ESIMS) studies of several A007 prodrugs in aqueous cyclomaltohexaose (alpha-cyclodextrin, alpha-CD), cyclomaltoheptaose (beta-cyclodextrin, beta-CD), and cyclomaltooctaose (gamma-cyclodextrin, gamma-CD) were performed. The acetic acid derivative of A007 should metabolize in vivo before becoming the A007 prodrug, while on the other hand, the glycine-modified A007 prodrug has surfactant-like physical properties and slowly hydrolyzed in the aqueous cyclodextrins by releasing free A007. ESIMS studies give insight into the process of prodrug hydrolysis in the presence of cyclodextrins and, hence, the influence of cyclodextrins on the timely release of the A007 prodrug. Formation of various molecular aggregates and cyclodextrin inclusion complexes of A007 prodrugs and their hydrolyzed products was demonstrated by ESIMS.
authors.affiliation: Department of Chemistry, University of New Orleans, New Orleans, LA 70148, United States.
authors.forename: Sarada
authors.initials: S
authors.lastname: Sagiraju
authors.forename: Kan
authors.initials: K
authors.lastname: Chen
authors.forename: Richard B
authors.initials: RB
authors.lastname: Cole
authors.forename: Branko S
authors.initials: BS
authors.lastname: Jursic
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000378:metabolism; D003505:Cyclodextrins / Q000737:chemistry* / Q000378:metabolism; D006835:Hydrazones / Q000737:chemistry* / Q000378:metabolism; D010636:Phenols / Q000737:chemistry* / Q000378:metabolism; D011355:Prodrugs / Q000737:chemistry* / Q000378:metabolism; D012995:Solubility; D021241:Spectrometry, Mass, Electrospray Ionization; D014867:Water / Q000737:chemistry
chemical_list: C097674:4,4'-dihydroxybenzophenone-2,4-dinitrophenylhydrazone; D000970:Antineoplastic Agents; D003505:Cyclodextrins; D006835:Hydrazones; D010636:Phenols; D011355:Prodrugs; D014867:Water