Vascular responses to hypoxia and ischemia.
Blood vessels function as conduits for the delivery of O(2) and nutrients. Hypoxia-inducible factor 1 (HIF-1) mediates adaptive transcriptional responses to hypoxia/ischemia that include expression of angiogenic cytokines/growth factors by hypoxic cells and expression of cognate receptors for these ligands by vascular cells and their progenitors. Impairment of HIF-1-dependent responses to hypoxia is a major factor contributing to the impaired vascular responses to ischemia that are associated with aging and diabetes.
Semenza
Gregg L
GL
Institute for Cell Engineering, Departments of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, MD, USA. gsemenza@jhmi.edu
D000375:Aging / Q000378:metabolism; D042501:Angiogenic Proteins / Q000378:metabolism; D000818:Animals; D001808:Blood Vessels / Q000378:metabolism* / Q000503:physiopathology; D015687:Cell Hypoxia; D003324:Coronary Artery Disease / Q000378:metabolism / Q000503:physiopathology; D003920:Diabetes Mellitus / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D051793:Hypoxia-Inducible Factor 1 / Q000378:metabolism; D007511:Ischemia / Q000378:metabolism* / Q000503:physiopathology; D018919:Neovascularization, Physiologic; D010100:Oxygen / Q000097:blood / Q000378:metabolism*; D015398:Signal Transduction; D014945:Wound Healing
D042501:Angiogenic Proteins; D051793:Hypoxia-Inducible Factor 1; D010100:Oxygen