title: Comparison of metformin treatment and laparoscopic ovarian diathermy in patients with polycystic ovary syndrome.
abstract: OBJECTIVE
  To compare hormone levels and clinical outcomes in patients with polycystic ovary syndrome (PCOS) after metformin therapy or laparoscopic ovarian diathermy (LOD) at 6 months follow-up.
  
  
  METHODS
  A randomized trial was conducted in 126 patients with PCOS who had a history of infertility for at least 1 year and resistance to clomiphene citrate (CC). Patients (n=63) received metformin treatment or underwent LOD (n=63).
  
  
  RESULTS
  Levels of follicle-stimulating hormone did not change in either group after the intervention (P>0.05). Serum levels of testosterone (P<0.001) and luteinizing hormone (P<0.001) were significantly lower after the treatment in both groups. The proportion of women with regular menstrual cycles increased significantly to 35% (P<0.001) in the LOD group and to 49% (P<0.001) in metformin group compared with before the intervention. Although proportion was higher in the metformin group compared with the LOD group, the difference was not significant (odds ratio 1.81; 95% CI, 0.88-3.69, P=0.1). Hirsutism decreased significantly from 100% to 79.37% (P<0.001) in both groups.
  
  
  CONCLUSIONS
  CC-resistant patients with PCOS were treated effectively by both metformin and LOD.
authors.affiliation: Department of Gynecology and Obstetrics, Roointan-Arash Hospital, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Mansoor
authors.initials: M
authors.lastname: Ashrafinia
authors.forename: Reihaneh
authors.initials: R
authors.lastname: Hosseini
authors.forename: Ashraf
authors.initials: A
authors.lastname: Moini
authors.forename: Bita
authors.initials: B
authors.lastname: Eslami
authors.forename: Zahra
authors.initials: Z
authors.lastname: Asgari
mesh_terms: D000328:Adult; D002996:Clomiphene / Q000627:therapeutic use; D003972:Diathermy; D005260:Female; D005300:Fertility Agents, Female / Q000627:therapeutic use; D006628:Hirsutism / Q000517:prevention & control; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007247:Infertility, Female / Q000209:etiology; D010535:Laparoscopy; D007986:Luteinizing Hormone / Q000097:blood; D008597:Menstrual Cycle / Q000097:blood; D008687:Metformin / Q000627:therapeutic use*; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000188:drug therapy* / Q000601:surgery*; D013739:Testosterone / Q000097:blood; D055815:Young Adult
chemical_list: D005300:Fertility Agents, Female; D007004:Hypoglycemic Agents; D002996:Clomiphene; D013739:Testosterone; D007986:Luteinizing Hormone; D008687:Metformin