title: Serotype distribution and antibiotic resistance of Streptococcus pneumoniae strains isolated from adults in France: evolution between 2001 and 2003.
abstract: Antibiotic-resistant Streptococcus pneumoniae (Sp) are described around the world. The present national surveillance study report analyzes more than 6000 Sp strains, isolated from adults across France in 2001 and 2003, from blood cultures (3086 in 2001 and 3164 in 2003), cerebrospinal fluid (respectively, 238 and 240), or middle ear fluid (respectively, 110 and 100). The proportion of isolates with reduced susceptibility to penicillin fell significantly between 2001 and 2003 from 46.5% to 43.9%. The proportion of high-level resistant strains to penicillin minimal inhibitory concentrations (MIC > 1 mg/L), amoxicillin, and cefotaxime (MIC > 2 mg/L) slightly decreased but remained low: 10.6%, 1.2%, and 0.2% in 2003. Resistance to other antibiotics (erythromycin, cotrimoxazole, tetracycline, and chloramphenicol) also decreased. Decrease in prevalence of penicillin-resistant Sp varied according to specimen source. The proportion of penicillin nonsusceptible pneumococci decreased in blood cultures and middle ear fluids between 2001 and 2003 but increased in cerebrospinal fluid (43.4% and 46.5%, respectively). Serotypes covered by the heptavalent vaccine accounted for 42.4% of all isolates recovered in 2001 and 46.1% in 2003. Prevalence of antibiotic-resistant Sp decreased in 2003 in France.
authors.affiliation: University Hospital Center (CHU) Lille-Regional Pneumococcal Observatories (ORP) Nord-Pas-de-Calais, Lille, France.
authors.forename: Micheline
authors.initials: M
authors.lastname: Roussel-Delvallez
authors.forename: Véronique
authors.initials: V
authors.lastname: Vernet-Garnier
authors.forename: Sandra
authors.initials: S
authors.lastname: Bourdon
authors.forename: Michel
authors.initials: M
authors.lastname: Brun
authors.forename: Blandine
authors.initials: B
authors.lastname: Cattier
authors.forename: Catherine
authors.initials: C
authors.lastname: Chanal
authors.forename: Hubert
authors.initials: H
authors.lastname: Chardon
authors.forename: Monique
authors.initials: M
authors.lastname: Chomarat
authors.forename: Jacques
authors.initials: J
authors.lastname: Croizé
authors.forename: Marie-Claude
authors.initials: MC
authors.lastname: Demachy
authors.forename: Pierre-Yves
authors.initials: PY
authors.lastname: Donnio
authors.forename: Philippe
authors.initials: P
authors.lastname: Dupont
authors.forename: Thierry
authors.initials: T
authors.lastname: Fosse
authors.forename: Alain
authors.initials: A
authors.lastname: Gravet
authors.forename: Bernadette
authors.initials: B
authors.lastname: Grignon
authors.forename: Geneviève
authors.initials: G
authors.lastname: Laurans
authors.forename: Jeanne
authors.initials: J
authors.lastname: Maugein
authors.forename: André
authors.initials: A
authors.lastname: Péchinot
authors.forename: Marie-Françoise
authors.initials: MF
authors.lastname: Prère
authors.forename: Pierre-Henri
authors.initials: PH
authors.lastname: Thoreux
authors.forename: Michel
authors.initials: M
authors.lastname: Vergnaud
authors.forename: Michèle
authors.initials: M
authors.lastname: Weber
authors.forename: Bruno
authors.initials: B
authors.lastname: Coignard
authors.forename: Laurent
authors.initials: L
authors.lastname: Gutmann
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Varon
authors.forename: Marie-Cécile
authors.initials: MC
authors.lastname: Ploy
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001769:Blood / Q000382:microbiology; D002555:Cerebrospinal Fluid / Q000382:microbiology; D003470:Culture Media; D024881:Drug Resistance, Bacterial; D005602:France / Q000453:epidemiology; D006801:Humans; D008826:Microbial Sensitivity Tests; D010034:Otitis Media with Effusion / Q000382:microbiology; D011008:Pneumococcal Infections / Q000453:epidemiology* / Q000382:microbiology; D011159:Population Surveillance; D015995:Prevalence; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000145:classification* / Q000187:drug effects* / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents; D003470:Culture Media