Stereocontrolled synthesis of oxaspirobicycles via Prins-pinacol annulation.
We have developed the stereoselective synthesis of 2-oxaspiro[m,n]alkane derivatives using the Prins-pinacol annulation of alkene diols with a wide range of aliphatic or aromatic aldehydes and ketones. This approach was further applied for the synthesis of oxatricyclic ring system.
Chavre
Satish N
SN
Center for Chemoinformatics Research, Life Science Division, Korea Institute of Science and Technology (KIST), Seoul, 136-791, Republic of Korea.
Ullapu
Punna Reddy
PR
Min
Sun-Joon
SJ
Lee
Jae Kyun
JK
Pae
Ae Nim
AN
Kim
Youseung
Y
Cho
Yong Seo
YS
D000438:Alcohols / Q000737:chemistry*; D000473:Alkanes / Q000138:chemical synthesis* / Q000737:chemistry; D000475:Alkenes / Q000737:chemistry; D003500:Cyclization; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010100:Oxygen / Q000737:chemistry; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D000438:Alcohols; D000473:Alkanes; D000475:Alkenes; D006571:Heterocyclic Compounds; D013141:Spiro Compounds; D010100:Oxygen