The effects of intravenous ciprofloxacin on the electrocardiogram of healthy dogs.
The purpose of this study was to evaluate the electrocardiographic effects of single intravenous dose of ciprofloxacin in dogs. Ten adult cross-breed dogs of both sexes were selected as the sample population. Baseline electrocardiographic values were recorded just before drug administration. Then the dogs received intravenous infusion of ciprofloxacin (10 mg/kg) over the fifteen minutes. The ECGs recorded at 15, 30, 60 and 120 minutes after ciprofloxacin administration. The ECG measurements of heart rate, PR interval, QRS interval, ST segment, T-wave amplitude and QT interval were taken from lead II. There was a small but significant increase in the longest QT intervals over baseline at T₆₀ (P = 0.041). The mean PR intervals, QTc intervals, JT intervals, ST segment, T-wave amplitude did not differ significantly before and after ciprofloxacin except for JT intervals at T₆₀ (P = 0.041). At this measurement point, there was an increased QT interval value of 0.02 second or 9.51% in comparison to the baseline. In Conclusions, Only minor QT intervals changes were observed after ciprofloxacin injection. Despite the occurrence of ECG changes following intravenous ciprofloxacin administration neither dangerous rhythm disturbances nor serious ECG changes were seen in this study.
Ghaffari
Masoud Selk
MS
Department of Clinical Studies, School of Veterinary Medicine, Islamic Azad University-Karaj Branch, Karaj, Iran. selkghaffari@gmail.com
Parsamehr
Reza
R
D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000494:pharmacology*; D004285:Dogs; D004562:Electrocardiography / Q000187:drug effects / Q000662:veterinary*; D005260:Female; D006321:Heart / Q000187:drug effects*; D007275:Injections, Intravenous / Q000662:veterinary; D008297:Male; D013997:Time Factors
D000890:Anti-Infective Agents; D002939:Ciprofloxacin