title: Magnetic resonance imaging of dissolved hyperpolarized 129Xe using a membrane-based continuous flow system.
abstract: A technique for continuous production of solutions containing hyperpolarized (129)Xe is explored for MRI applications. The method is based on hollow fiber membranes which inhibit the formation of foams and bubbles. A systematic analysis of various carrier agents for hyperpolarized (129)Xe has been carried out, which are applicable as contrast agents for in vivo MRI. The image quality of different hyperpolarized Xe solutions is compared and MRI results obtained in a clinical as well as in a nonclinical MRI setting are provided. Moreover, we demonstrate the application of (129)Xe contrast agents produced with our dissolution method for lung MRI by imaging hyperpolarized (129)Xe that has been both dissolved in and outgassed from a carrier liquid in a lung phantom, illustrating its potential for the measurement of lung perfusion and ventilation.
authors.affiliation: Max Planck Institute for Polymer Research, 55128 Mainz, Germany.
authors.forename: N
authors.initials: N
authors.lastname: Amor
authors.forename: P P
authors.initials: PP
authors.lastname: Zänker
authors.forename: P
authors.initials: P
authors.lastname: Blümler
authors.forename: F M
authors.initials: FM
authors.lastname: Meise
authors.forename: L M
authors.initials: LM
authors.lastname: Schreiber
authors.forename: A
authors.initials: A
authors.lastname: Scholz
authors.forename: J
authors.initials: J
authors.lastname: Schmiedeskamp
authors.forename: H W
authors.initials: HW
authors.lastname: Spiess
authors.forename: K
authors.initials: K
authors.lastname: Münnemann
mesh_terms: D001672:Biocompatible Materials; D007091:Image Processing, Computer-Assisted; D008168:Lung / Q000033:anatomy & histology / Q000737:chemistry / Q000502:physiology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008567:Membranes, Artificial; D019047:Phantoms, Imaging; D011652:Pulmonary Circulation / Q000502:physiology; D015656:Respiratory Mechanics; D012996:Solutions; D014979:Xenon Isotopes / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D008567:Membranes, Artificial; D012996:Solutions; D014979:Xenon Isotopes