Permethylated beta-cyclodextrin in liquid poly(oxyethylene) as a stationary phase for capillary gas chromatography.
This paper reports the study of poly(oxyethylene) as a solvent for heptakis(2,3,6-tri-O-methyl)-beta-cyclodextrin (PM-beta-CD) and the potential of these mixtures for constructing enantioselective gas chromatography columns. Enantioseparations of volatile racemic mixtures using capillaries coated with 10-50% PM-beta-CD diluted in Carbowax 20M were evaluated. The influence of the polymer type on retention, separation and reproducibility over a period of time is critically discussed. The poly(oxyethylene)-based columns were also compared to columns prepared by dilution of PM-beta-CD in two polysiloxanes, SE-30 and SE-54, at several temperatures. Finally, we evaluated a new stationary phase prepared by crosslinking the chiral selector to the poly(oxyethylene) matrix.
Grisales
Jaiver Osorio
JO
División Química Analítica, Facultad de Ciencias Exactas, Universidad Nacional de La Plata y CIDEPINT, 47 y 115, 1900 La Plata, Argentina.
Lebed
Pablo J
PJ
Keunchkarian
Sonia
S
González
Francisco R
FR
Castells
Cecilia B
CB
D002849:Chromatography, Gas / Q000379:methods*; D008745:Methylation; D011092:Polyethylene Glycols / Q000737:chemistry*; D047392:beta-Cyclodextrins / Q000737:chemistry*
D047392:beta-Cyclodextrins; D011092:Polyethylene Glycols