LINGO1 rs9652490 is associated with essential tremor and Parkinson disease.
Recently, a variant in LINGO1 (rs9652490) was found to associate with increased risk of essential tremor. We set out to replicate this association in an independent case-control series of essential tremor from North America. In addition, given the clinical and pathological overlap between essential tremor and Parkinson disease, we also evaluate the effect of LINGO1 rs9652490 in two case-control series of Parkinson disease. Our study demonstrates a significant association between LINGO1 rs9652490 and essential tremor (P = 0.014) and Parkinson disease (P = 0.0003), thus providing the first evidence of a genetic link between both diseases.
Vilariño-Güell
Carles
C
Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA. VilarinoGuell.Carles@mayo.edu
Ross
Owen A
OA
Wider
Christian
C
Jasinska-Myga
Barbara
B
Cobb
Stephanie A
SA
Soto-Ortolaza
Alexandra I
AI
Kachergus
Jennifer M
JM
Keeling
Brett H
BH
Dachsel
Justus C
JC
Melrose
Heather L
HL
Behrouz
Bahareh
B
Wszolek
Zbigniew K
ZK
Uitti
Ryan J
RJ
Aasly
Jan O
JO
Rajput
Alex
A
Farrer
Matthew J
MJ
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D020329:Essential Tremor / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D007391:International Cooperation; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000235:genetics*; D010300:Parkinson Disease / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*
C482293:LINGO1 protein, human; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins