The application of conductivity measurements for preliminary assessments of chlorhexidine and lidocaine hydrochloride release from methylcellulose gel at various temperatures.
For the evaluation of conductivity measurements in the control and monitoring of release process, high number of conductivity measurements was performed. The measurements were done for the compositions of chlorhexidine with methylcellulose, and lidocaine hydrochloride with methylcellulose. Chlorhexidine, a very slightly soluble substance is released from the methylcellulose bead in the amounts ca. 30%-70%, and it depends of temperature of the release process. The lidocaine hydrochloride at the same time is released from methylcellulose formulation in 70-100%. The conductivity in the donor compartment at the start point, and in the acceptor compartment at the termination point, reflect the released amounts of the drug. This study confirms the possibility of application of conductivity measurements for the preliminary assessments of the kinetics of release of soluble and practically insoluble substances from the nonionic polymeric matrix.
Musial
Witold
W
Department for Textile Materials and Design University of Maribor, Slovenia. witold@ktpl.am.wroc.pl
Kokol
Vanja
V
Voncina
Bojana
B
D002626:Chemistry, Pharmaceutical; D002710:Chlorhexidine / Q000737:chemistry*; D004058:Diffusion; D004337:Drug Carriers / Q000737:chemistry*; D005782:Gels / Q000737:chemistry; D008012:Lidocaine / Q000737:chemistry*; D008747:Methylcellulose / Q000737:chemistry*; D012995:Solubility; D013696:Temperature
D004337:Drug Carriers; D005782:Gels; D008747:Methylcellulose; D008012:Lidocaine; D002710:Chlorhexidine