Perinatal exposure to music protects spatial memory against callosal lesions.
Several studies have indicated that the exposure of rodents to music modulates brain development and neuroplasticity, by mechanisms that involve facilitated hippocampal neurogenesis, neurotrophin synthesis and glutamatergic signaling. This study focused on the potential protection that the perinatal exposure to music, between postnatal days 2 and 32, could offer against functional deficits induced by neonatal callosotomy in rats. The spontaneous alternation and marble-burying behaviors were longitudinally measured in callosotomized and control rats that had been exposed to music or not. The results indicated that the neonatal callosotomy-induced spontaneous alternation deficits that became apparent only after postnatal day 45, about the time when the rat corpus callosum reaches its maximal levels of myelination. The perinatal exposure to music efficiently protected the spontaneous alternation performance against the deficits induced by callosotomy. The present findings may offer important insights into music-induced neuroplasticity, relevant to brain development and neurorehabilitation.
Amagdei
Anca
A
Program of Cognitive Neuroscience, Department of Psychology, Babes-Bolyai University, 37 Republicii St., Cluj-Napoca, CJ 400015, Romania.
Balteş
Felicia Rodica
FR
Avram
Julia
J
Miu
Andrei C
AC
D000818:Animals; D000831:Animals, Newborn; D001307:Auditory Perception / Q000502:physiology; D003337:Corpus Callosum / Q000254:growth & development / Q000293:injuries* / Q000503:physiopathology; D005260:Female; D008137:Longitudinal Studies; D008297:Male; D008568:Memory / Q000502:physiology*; D008569:Memory Disorders / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D009146:Music; D009473:Neuronal Plasticity; D009483:Neuropsychological Tests; D011897:Random Allocation; D051381:Rats; D013028:Space Perception / Q000502:physiology*