Differentiation and apoptosis in UVA-irradiated cells treated with furocoumarin derivatives.
In this review we summarize the structure and biological effects of linear and angular psoralens. These compounds exhibit interesting biological effects on the cell cycle, apoptosis and differentiation. These molecules should be considered promising drugs in the therapy of several diseases, including psoriasis, mycosis fungoides and cancer. Also, preclinical data demonstrate a possible use of these molecules for the treatment of beta-thalassemia and other hematological disorders.
Viola
Giampietro
G
Department of Pharmaceutical Sciences, University of Padova, Padova, Italy.
Salvador
Alessia
A
Vedaldi
Daniela
D
Dall'Acqua
Francesco
F
Bianchi
Nicoletta
N
Zuccato
Cristina
C
Borgatti
Monica
M
Lampronti
Ilaria
I
Gambari
Roberto
R
D000818:Animals; D017209:Apoptosis / Q000187:drug effects* / Q000528:radiation effects; D002453:Cell Cycle / Q000187:drug effects; D002454:Cell Differentiation / Q000187:drug effects* / Q000528:radiation effects; D005363:Ficusin / Q000737:chemistry / Q000494:pharmacology*; D011564:Furocoumarins / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D011701:PUVA Therapy / Q000379:methods; D014466:Ultraviolet Rays
D011564:Furocoumarins; C011659:angelicin; D005363:Ficusin