title: [Rationale for the use of local antibacterial therapy in the postoperative period following rhinosurgical interventions].
abstract: The objective of this study was to assess the appropriateness of using local antibacterial therapy in the postoperative period following rhinosurgical interventions based on the results of hemiluminescent, microbiological, and cytological studies. They included 20 patients who had underwent surgical intervention in the nasal cavity. The control group comprised 20 healthy subjects. The early postoperative period was characterized by a rise in the number and activity of neutrophilic granulocytes in blood and nasal mucosa along with a substantial increase of the abundance of bacterial flora in the nasal cavity. This suggests the necessity of local antibacterial therapy during the postoperative period following rhinosurgical interventions. Bioparox (fusafungine) spray is recommended as the optimal antibacterial preparation for the purpose by virtue of its broad spectrum of antimicrobial activity and strong anti-inflammatory action. Bioparox has an advantage over other sprays and aerosols in terms of pharmacokinetic characteristics.
authors.forename: K G
authors.initials: KG
authors.lastname: Dobretsov
authors.forename: V Iu
authors.initials: VIu
authors.lastname: Afon'kin
authors.forename: A V
authors.initials: AV
authors.lastname: Sipkin
authors.forename: O A
authors.initials: OA
authors.lastname: Kolenchukova
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000336:Aerosols; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D011182:Postoperative Care / Q000379:methods*; D012225:Rhinoplasty / Q000379:methods*; D013530:Surgical Wound Infection / Q000517:prevention & control*; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects; D055815:Young Adult
chemical_list: D000336:Aerosols; D000900:Anti-Bacterial Agents