title: Advances in Ewing's sarcoma research: where are we now and what lies ahead?
abstract: Ewing's sarcoma family tumors (EFT) are characterized by specific chromosomal translocations, which lead to EWS/ETS transcription factors. Elucidation of EWS/ETS target gene networks within the context of other signaling pathways, together with the identification of the initiating cell, and the development of genetically engineered mice will hopefully lead to biology-based therapeutic strategies for these tumors.
authors.affiliation: Laboratory of Molecular Pathology of Sarcomas, Centro de Investigación del Cáncer-Instituto de Biología Molecular y Celular del Cáncer (IBMCC), Universidad de Salamanca-CSIC, Salamanca, Spain.
authors.forename: José Luis
authors.initials: JL
authors.lastname: Ordóñez
authors.forename: Daniel
authors.initials: D
authors.lastname: Osuna
authors.forename: David
authors.initials: D
authors.lastname: Herrero
authors.forename: Enrique
authors.initials: E
authors.lastname: de Alava
authors.forename: Juan
authors.initials: J
authors.lastname: Madoz-Gúrpide
mesh_terms: D000818:Animals; D006801:Humans; D051379:Mice; D015514:Oncogene Proteins, Fusion / Q000235:genetics / Q000378:metabolism; D051789:Proto-Oncogene Protein c-fli-1 / Q000235:genetics / Q000378:metabolism; D034802:RNA-Binding Protein EWS; D012512:Sarcoma, Ewing / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000628:therapy
chemical_list: C106031:EWS-FLI fusion protein; D015514:Oncogene Proteins, Fusion; D051789:Proto-Oncogene Protein c-fli-1; D034802:RNA-Binding Protein EWS