title: Laboratory-based surveillance of Streptococcus pneumoniae invasive disease in children in 10 Latin American countries: a SIREVA II project, 2000-2005.
abstract: BACKGROUND
  For the last 14 years the Pan American Health Organization has been promoting surveillance of invasive pneumococcal disease in Latin American children for better understanding of the disease tendencies regarding capsular types circulation in each country and susceptibility to antimicrobials.
  
  
  METHODS
  Laboratory-based surveillance data from 10 Latin American countries collected from 2000 to 2005 were analyzed, including serotype distribution and susceptibility to beta-lactam antibiotics.
  
  
  RESULTS
  Although 61 different capsular types were identified during the 6-year surveillance, 13 serotypes accounted for 86% of all isolates. These were consistently the most prevalent throughout the study period with serotype 14 predominating. Diminished susceptibility to penicillin was detected in 38% of all Streptococcus pneumoniae isolates, with the highest prevalence in Dominican Republic and Mexico. Decreased susceptibility to penicillin increased in Brazil and Colombia whereas decreased high resistance rates was recorded in Chile.
  
  
  CONCLUSIONS
  These data indicate that 10 countries of the Region continue to have high quality laboratory-based surveillance for pneumococcal disease thus generating valuable information so that healthcare decision makers may prioritize interventions. The heptavalent vaccine will potentially cover from 52.4% to 76.5% of strains causing invasive pneumococcal disease and the 13 valent from 76.7% to 88.3%.
authors.affiliation: Grupo de Microbiologia, Instituto Nacional de Salud, Bogotá, Colombia. ecastaneda21@gmail.com
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Castañeda
authors.forename: Clara I
authors.initials: CI
authors.lastname: Agudelo
authors.forename: Mabel
authors.initials: M
authors.lastname: Regueira
authors.forename: Alejandra
authors.initials: A
authors.lastname: Corso
authors.forename: Maria C de Cunto
authors.initials: MC
authors.lastname: Brandileone
authors.forename: Angela P
authors.initials: AP
authors.lastname: Brandão
authors.forename: Aurora
authors.initials: A
authors.lastname: Maldonado
authors.forename: Juan C
authors.initials: JC
authors.lastname: Hormazabal
authors.forename: Isis T
authors.initials: IT
authors.lastname: Martínez
authors.forename: Rafael
authors.initials: R
authors.lastname: Llanes
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Sánchez
authors.forename: Jesús M
authors.initials: JM
authors.lastname: Feris
authors.forename: Gabriela
authors.initials: G
authors.lastname: Echaniz-Aviles
authors.forename: María N
authors.initials: MN
authors.lastname: Carnalla-Barajas
authors.forename: Mónica G V
authors.initials: MG
authors.lastname: Terrazas
authors.forename: Irma H
authors.initials: IH
authors.lastname: Monroy
authors.forename: Gustavo
authors.initials: G
authors.lastname: Chamorro
authors.forename: Natalie
authors.initials: N
authors.lastname: Weiler
authors.forename: Teresa
authors.initials: T
authors.lastname: Camou
authors.forename: Gabriela G
authors.initials: GG
authors.lastname: Gabarrot
authors.forename: Enza
authors.initials: E
authors.lastname: Spadola
authors.forename: Daisy
authors.initials: D
authors.lastname: Payares
authors.forename: Jean M
authors.initials: JM
authors.lastname: Gabastou
authors.forename: José Luis
authors.initials: JL
authors.lastname: Di Fabio
authors.forename: Fernando
authors.initials: F
authors.lastname: de la Hoz
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D015373:Bacterial Typing Techniques; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007843:Latin America / Q000453:epidemiology; D008297:Male; D008826:Microbial Sensitivity Tests; D010403:Penicillin Resistance; D011008:Pneumococcal Infections / Q000453:epidemiology* / Q000382:microbiology*; D011159:Population Surveillance / Q000379:methods; D015995:Prevalence; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000145:classification* / Q000187:drug effects / Q000302:isolation & purification*; D047090:beta-Lactams / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D047090:beta-Lactams