title: Stimulant medication use and response to growth hormone therapy: an NCGS database analysis.
abstract: OBJECTIVE
  Determine (1) frequency of attention-deficit hyperactivity disorder (ADHD) treatment and (2) growth responses in growth hormone (GH)-treated children who are receiving ADHD medication versus GH alone.
  
  
  METHODS
  Prepubertal children with idiopathic short stature (ISS) or GH deficiency (IGHD) enrolled in Genentech's National Cooperative Growth Study. ADHD treatment was determined by documentation of psycho-stimulant medication use at enrollment.
  
  
  RESULTS
  ADHD medication use increased from 0.8% (7/850) in 1985 to 5.8% (752/12,113) in 2005. First-year GH treatment response for ADHD + IGHD versus IGHD: 8.5 +/- 2.0 vs. 9.4 +/- 2.6 cm/year, but when adjusted for age, sex, and enrollment body mass index, the difference is clinically insignificant (-0.4 cm/year). First-year growth was similar in all ISS: 8.1 +/- 1.9 versus 8.6 +/- 2.1 cm/year (ADHD + ISS vs. ISS, an adjusted -0.2-cm/year difference).
  
  
  CONCLUSIONS
  Increasing numbers of GH-treated children are taking ADHD medications and their growth responses during the first year of GH therapy are similar to those not taking ADHD medications.
authors.affiliation: University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA. frindikpaul@uams.edu
authors.forename: J Paul
authors.initials: JP
authors.lastname: Frindik
authors.forename: Alba
authors.initials: A
authors.lastname: Morales
authors.forename: John
authors.initials: J
authors.lastname: Fowlkes
authors.forename: Stephen
authors.initials: S
authors.lastname: Kemp
authors.forename: Kathryn
authors.initials: K
authors.lastname: Thrailkill
authors.forename: Barbara
authors.initials: B
authors.lastname: Lippe
authors.forename: Ken
authors.initials: K
authors.lastname: Dana
mesh_terms: D001289:Attention Deficit Disorder with Hyperactivity / Q000150:complications / Q000188:drug therapy*; D000697:Central Nervous System Stimulants / Q000627:therapeutic use*; D002648:Child; D005260:Female; D006128:Growth / Q000187:drug effects; D006130:Growth Disorders / Q000150:complications / Q000188:drug therapy*; D019382:Human Growth Hormone / Q000172:deficiency* / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D012189:Retrospective Studies
chemical_list: D000697:Central Nervous System Stimulants; D019382:Human Growth Hormone