title: Ir-catalyzed oxidative desymmetrization of meso-diols.
abstract: The catalytic oxidative desymmetrization of meso-diols was realized using a chiral iridium catalyst. In particular, the reaction is effective for the cyclic diols to give the corresponding hydroxy ketones in high chemical yields with high ee's. With this reaction as a key step, a short-step synthesis of common intermediate of ottelione and scyphostatin was achieved.
authors.affiliation: The Institute of Scientific and Industrial Research, Osaka University, Mihogaoka, Ibaraki-shi, Osaka 567-0047, Japan. suzuki-t@sanken.osaka-u.ac.jp
authors.forename: Takeyuki
authors.initials: T
authors.lastname: Suzuki
authors.forename: Kazem
authors.initials: K
authors.lastname: Ghozati
authors.forename: Tadashi
authors.initials: T
authors.lastname: Katoh
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Sasai
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D002384:Catalysis; D007495:Iridium / Q000737:chemistry*; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D008968:Molecular Conformation; D010084:Oxidation-Reduction; D013237:Stereoisomerism
chemical_list: D000438:Alcohols; D007659:Ketones; D007495:Iridium