Inhibitory effects of guarana seed extract on passive cutaneous anaphylaxis and mast cell degranulation.
This study investigated the effects of guarana seed extract (GSE) on an anti-allergic mechanism. GSE orally administered inhibited the anti-dinitrophenol IgE-induced passive cutaneous anaphylaxis reaction in mice. Furthermore, it inhibited the degranulation of rat basophilic leukemia RBL-2H3 cells. It had no cytotoxicity on RBL-2H3 cells. These results show that GSE is a candidate for effective therapeutic material for allergic diseases.
Jippo
Tomoko
T
Department of Food and Nutrition, Faculty of Human Life Sciences, Senri Kinran University, 5-25-1 Fujishirodai, Suita, Osaka 565-0873, Japan. k-jippou@cs.kinran.ac.jp
Kobayashi
Yuko
Y
Sato
Harumi
H
Hattori
Atsushi
A
Takeuchi
Hiroaki
H
Sugimoto
Keiichiro
K
Shigekawa
Munekazu
M
D000818:Animals; D015550:Cell Degranulation / Q000187:drug effects*; D045744:Cell Line, Tumor; D002851:Chromatography, High Pressure Liquid; D008407:Mast Cells / Q000166:cytology / Q000187:drug effects*; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects*; D032126:Paullinia / Q000196:embryology*; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D012639:Seeds / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet
D010936:Plant Extracts