title: Radiographic repair in three Japanese patients with rheumatoid arthritis treated with bucillamine.
abstract: Bucillamine (Bc) is a cysteine derivative with two SH groups, and a homolog of D-penicillamine, a disease-modifying antirheumatic drug (DMARD) widely used in Japan. However, it remains unclear whether Bc repairs bone erosion in patients with RA. Here, we treated three RA patients with Bc who subsequently showed radiographic repair of erosions and cysts.
authors.affiliation: Institute of Rheumatology, Tokyo Women's Medical University, 10-22 Kawada-cho, Shinjuku-ku, Tokyo, 162-0054, Japan. ynn@ior.twmu.ac.jp
authors.forename: Yuki
authors.initials: Y
authors.lastname: Nanke
authors.forename: Masako
authors.initials: M
authors.lastname: Iwatani
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Kobashigawa
authors.forename: Toru
authors.initials: T
authors.lastname: Yago
authors.forename: Hisashi
authors.initials: H
authors.lastname: Yamanaka
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kotake
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000000981:diagnostic imaging* / Q000188:drug therapy* / Q000473:pathology; D001175:Arthrography; D001842:Bone and Bones / Q000000981:diagnostic imaging* / Q000473:pathology*; D003545:Cysteine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D018450:Disease Progression; D005260:Female; D006801:Humans; D007596:Joints / Q000473:pathology; D008297:Male; D008875:Middle Aged; D020127:Recovery of Function; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D003545:Cysteine; C026535:bucillamine