title: [Relationship between RUNX3 expression and precancerous gastric lesions in high-risk population].
abstract: OBJECTIVE
  To evaluate the association between RUNX3 expression and Helicobacter pylori (H. pylori)-associated precancerous gastric lesions.
  
  
  METHODS
  A population-based study was conducted in Linqu County, Shandong Province, a high-risk area of gastric cancer in China. RUNX3 expression was determined by immunohistochemistry analysis in 1 026 H. pylori infected subjects with different gastric lesions.
  
  
  RESULTS
  Among 1,026 subjects, 359 (35.0%, 359/1,026) was positive. The prevalence rates of RUNX3 expression decreased steadily with severity of gastric lesions, 65.6%(40/61) among those with superficial gastritis /normal (SG/N), and 22.4%(60/268) among those with dysplasia (DYS) (P<0.01). Multinomial logistic regression analysis indicated that the risk of advanced gastric lesions were significantly increased for chronic atrophic gastritis [CAG, odds ratio (OR)=2.83, 95% confidence interval (CI: 1.58 to 5.06), intestinal metaplasia (IM, OR=3.52, 95% CI: 1.98 to 6.24) and DYS (OR=7.19, 95% CI: 3.81 to 13.56)] in subjects with negative RUNX3 expression compared with positive. Furthermore, compared to subjects with positive RUNX3 expression and non-smoking (or non-drinking), significantly increased risk of IM or DYS was observed in subjects with negative RUNX3 expression, the ORs ranged from 2.78 to 12.29.
  
  
  CONCLUSIONS
  Our findings indicate a significantly negative correlation between RUNX3 expression and severity of H. pylori-associated gastric lesions, suggesting that decreased expression of RUNX3 may play an important role in evolution of precancerous gastric lesions.
authors.affiliation: Department of Cancer Epidemiology, Peking University School of Oncology, Beijing Cancer Hospital & Institute, Beijing 100142, China.
authors.forename: Wen-qing
authors.initials: WQ
authors.lastname: Li
authors.forename: Kai-feng
authors.initials: KF
authors.lastname: Pan
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhang
authors.forename: Lian
authors.initials: L
authors.lastname: Zhang
authors.forename: Jun-ling
authors.initials: JL
authors.lastname: Ma
authors.forename: Tong
authors.initials: T
authors.lastname: Zhou
authors.forename: Ji-you
authors.initials: JY
authors.lastname: Li
authors.forename: Zheng
authors.initials: Z
authors.lastname: Wang
authors.forename: Ying
authors.initials: Y
authors.lastname: Su
authors.forename: Wei-cheng
authors.initials: WC
authors.lastname: You
mesh_terms: D000328:Adult; D050677:Core Binding Factor Alpha 3 Subunit / Q000235:genetics / Q000378:metabolism*; D015536:Down-Regulation; D005260:Female; D005756:Gastritis / Q000378:metabolism / Q000382:microbiology*; D016481:Helicobacter Infections / Q000378:metabolism*; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D011230:Precancerous Conditions / Q000378:metabolism* / Q000473:pathology; D013274:Stomach Neoplasms / Q000378:metabolism*
chemical_list: D050677:Core Binding Factor Alpha 3 Subunit; C493729:Runx3 protein, human