title: A general procedure for the preparation of beta-ketophosphonates.
abstract: A mild, high-yielding procedure for the preparation of beta-ketophosphonates is described. The condensation is general with respect to the ester and phosphonate, and the products are obtained in high yields within minutes at 0 degrees C. The reaction procedure is operationally simple and amenable to large-scale preparations.
authors.affiliation: Department of Process Research, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, USA. kevin_maloney@merck.com
authors.forename: Kevin M
authors.initials: KM
authors.lastname: Maloney
authors.forename: John Y L
authors.initials: JY
authors.lastname: Chung
mesh_terms: D015394:Molecular Structure; D063065:Organophosphonates / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D063065:Organophosphonates