title: Mitochondrial DNA haplogroups in the Czech population compared to other European countries.
abstract: The analysis of mtDNA haplogroup frequency in various populations is a tool for studying human history and population dynamics. The aim of this study is to map the frequency of major mtDNA haplogroups in 300 maternally unrelated individuals representing the Czech population of the central part of the Czech Republic. Eighteen polymorphic sites in the coding region of mtDNA were screened by PCR-RFLP to determine 11 mtDNA haplogroups and 5 subhaplogroups. The most frequent haplogroups were H (41%) and U (21%). Less frequent haplogroups were J and T, each with a frequency of 8%. Frequencies of other haplogroups (V, K, HV, W, preV, X, and I) did not exceed 5%. The results of our study reveal that the frequency of mtDNA haplogroups in the Czech population is similar to the frequencies obtained in other European countries, especially Poland, Germany, and Russia. On the contrary, significant differences in haplogroup frequency were found between the Czech and Finnish populations (haplogroups U, T, W) and populations from Bulgaria and Turkey (haplogroups H).
authors.affiliation: Charles University, First Faculty of Medicine, Department of Pediatrics, Prague, Czech Republic.
authors.forename: Vendula
authors.initials: V
authors.lastname: Vidrová
authors.forename: Markéta
authors.initials: M
authors.lastname: Tesarová
authors.forename: Eva
authors.initials: E
authors.lastname: Trefilova
authors.forename: Tomás
authors.initials: T
authors.lastname: Honzík
authors.forename: Martin
authors.initials: M
authors.lastname: Magner
authors.forename: Jirí
authors.initials: J
authors.lastname: Zeman
mesh_terms: D016009:Chi-Square Distribution; D003604:Czechoslovakia; D004272:DNA, Mitochondrial / Q000235:genetics*; D005828:Genetics, Population; D006239:Haplotypes; D006801:Humans; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D011157:Population Dynamics; D044382:Population Groups / Q000235:genetics*; D044465:White People / Q000235:genetics*
chemical_list: D004272:DNA, Mitochondrial