title: High-frequency rTMS over the supplementary motor area improves bradykinesia in Parkinson's disease: subanalysis of double-blind sham-controlled study.
abstract: A double-blind sham-controlled study demonstrated that high-frequency repetitive transcranial magnetic stimulation (rTMS) over the supplementary motor area (SMA) provided relief of motor symptoms in patients with Parkinson's disease (PD). However, it remains to be determined which parkinsonian symptoms were improved by this treatment. Subanalysis of Unified Parkinson Disease Rating Scale revealed that rTMS over SMA significantly improved bradykinesia in PD. Results support the hypothesis that neuronal activity of SMA was profoundly associated with hypokinetic symptoms in PD.
authors.affiliation: Department of Neurology, Division of Neuroscience, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. mhamada-tky@umin.ac.jp
authors.forename: Masashi
authors.initials: M
authors.lastname: Hamada
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Ugawa
authors.forename: Sadatoshi
authors.initials: S
authors.lastname: Tsuji
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001132:Arm / Q000294:innervation / Q000503:physiopathology; D004185:Disability Evaluation; D004311:Double-Blind Method; D005260:Female; D005625:Frontal Lobe / Q000502:physiology*; D006801:Humans; D018476:Hypokinesia / Q000503:physiopathology / Q000628:therapy*; D007866:Leg / Q000294:innervation / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000502:physiology*; D009127:Muscle Rigidity / Q000503:physiopathology / Q000628:therapy; D009434:Neural Pathways / Q000502:physiology; D017063:Outcome Assessment, Health Care; D010300:Parkinson Disease / Q000503:physiopathology / Q000628:therapy*; D050781:Transcranial Magnetic Stimulation / Q000379:methods*; D016896:Treatment Outcome; D014202:Tremor / Q000503:physiopathology / Q000628:therapy