title: Assessment of endothelial (dys)function in atrial fibrillation.
abstract: Atrial fibrillation (AF) is associated with an increased risk of mortality and morbidity from stroke and thromboembolism. Endothelial damage or dysfunction may contribute to this increased risk of thromboembolism via the mediation of a prothrombotic or hypercoagulable state. However, the precise pathophysiological mechanism(s) relating endothelial (dys)function to AF and thromboembolism are yet to be fully elucidated. This review article aims to provide a comprehensive overview of endothelial (dys)function and AF, as well as the merits and limitations of the different methods used to assess endothelial function in AF.
authors.affiliation: University of Birmingham Centre for Cardiovascular Science, City Hospital, Birmingham, B18 7QH, UK.
authors.forename: Suresh
authors.initials: S
authors.lastname: Krishnamoorthy
authors.forename: Sern H
authors.initials: SH
authors.lastname: Lim
authors.forename: Gregory Y H
authors.initials: GY
authors.lastname: Lip
mesh_terms: D000818:Animals; D001281:Atrial Fibrillation / Q000150:complications / Q000401:mortality / Q000503:physiopathology*; D015415:Biomarkers / Q000032:analysis; D004730:Endothelium, Vascular / Q000503:physiopathology*; D006801:Humans; D012307:Risk Factors; D020521:Stroke / Q000209:etiology / Q000401:mortality / Q000503:physiopathology; D013923:Thromboembolism / Q000209:etiology / Q000401:mortality / Q000503:physiopathology*
chemical_list: D015415:Biomarkers