Crystallizations, solid-state phase transformations and dissolution behavior explained by dispersive kinetic models based on a Maxwell-Boltzmann distribution of activation energies: theory, applications, and practical limitations.
The potential applications of dispersive kinetic models range from solid-state conversions to gas-phase chemical physics and to microbiology. Here, the derivation and application of two such models, for use in solid-state applications, is presented. The models are based on the concept of a Maxwell-Boltzmann distribution of activation energies. The ability of the models to fit/explain an assortment of asymmetric, sigmoidal conversion-versus-time transients presented in the recent literature, as well as to provide physicochemical interpretations of the kinetics via the two fit parameters, alpha and beta, makes them a powerful tool for understanding nucleation/denucleation rate-limited processes that are involved in many phase transformations, dissolutions and crystallizations.
Skrdla
Peter J
PJ
Merck & Company, Inc., RY818-B205, P.O. Box 2000, 126 East Lincoln Avenue, Rahway, New Jersey 07065, USA. peter_skrdla@merck.com
D003460:Crystallization; D018698:Glutamic Acid / Q000737:chemistry; D007700:Kinetics; D008956:Models, Chemical; D010316:Particle Size; D044367:Phase Transition; D012997:Solvents / Q000737:chemistry; D013806:Theophylline / Q000737:chemistry; D013844:Thiazoles / Q000737:chemistry
D012997:Solvents; D013844:Thiazoles; D018698:Glutamic Acid; D013806:Theophylline