title: Association between markers of inflammation, fibrosis and hypervolemia in peritoneal dialysis patients.
abstract: OBJECTIVE
  Volume expansion in peritoneal dialysis (PD) patients is associated with left ventricular hypertrophy. The link between inflammation and hypervolemia has not been extensively studied. The aim of this study was to determine if an association exists between hypervolemia and markers of inflammation in PD patients.
  
  
  METHODS
  In this cross-sectional study of 22 prevalent PD patients, volume was determined by bioelectrical impedance analysis. Serum and peritoneal effluent interleukin-6 (IL-6) and peritoneal transforming growth factor (TGF)-beta(1) were measured. A fast peritoneal equilibration test determined peritoneal transport status.
  
  
  RESULTS
  Bioimpedance-derived measures of hypervolemia correlated with peritoneal effluent IL-6 and TGF-beta(1). Peritoneal IL-6 was also associated with high peritoneal transport status.
  
  
  CONCLUSIONS
  Markers of inflammation and fibrosis (peritoneal IL-6 and TGF-beta(1)) are associated with markers of hypervolemia.
authors.affiliation: Division of Nephrology, McMaster University and St. Joseph's Healthcare, Hamilton, Ont., Canada.
authors.forename: Azim S
authors.initials: AS
authors.lastname: Gangji
authors.forename: K Scott
authors.initials: KS
authors.lastname: Brimble
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Margetts
mesh_terms: D015415:Biomarkers / Q000032:analysis; D001810:Blood Volume; D003430:Cross-Sectional Studies; D005355:Fibrosis / Q000175:diagnosis* / Q000209:etiology; D006801:Humans; D007249:Inflammation / Q000175:diagnosis* / Q000209:etiology; D015850:Interleukin-6 / Q000032:analysis; D008875:Middle Aged; D010530:Peritoneal Dialysis; D010537:Peritoneum / Q000737:chemistry / Q000473:pathology; D051436:Renal Insufficiency, Chronic / Q000473:pathology*; D053773:Transforming Growth Factor beta1 / Q000032:analysis
chemical_list: D015415:Biomarkers; D015850:Interleukin-6; D053773:Transforming Growth Factor beta1