title: Olive oil-diet improves the simvastatin effects with respect to sunflower oil-diet in men with increased cardiovascular risk: a preliminary study.
abstract: OBJECTIVE
  Concomitant intake of statins together with certain foods may affect their therapeutic effects. The purpose of this preliminary study was to determine the modulating effect of two culinary oils on the hypolipemic effect of statins.
  
  
  METHODS
  Twenty-five men with severe hypercholesterolemia and high estimate cardiovascular risk (> 20% according to the Adult Treatment Panel III of USA National Institutes of Health, ATP-III) were enrolled in an observational follow-up study to test lipoprotein profile changes after ix month 20-mg/d Simvastatin treatment. Thirteen volunteers using sunflower oil as the habitual culinary fat, and 12 using olive oil, were selected by non-probabilistic incidental sampling. Volunteers consent in follow their habitual diets and to maintain diet characteristics throughout the study. Diet was evaluated through the study by three 24-h recalls and a food frequency questionnaire.
  
  
  RESULTS
  The energy contribution of fat (P = 0.019) and MUFA (P < 0.001) was higher in the olive oil-group while that of PUFA (P = 0.001) and alcohol (P = 0.005) was higher in the sunflower oil-group. TC/HDL-cholesterol and the ATP-III 10-year risk percent decreased more (P < 0.05) in the olive oil group. TC and the TC/HDL-cholesterol and the LDL-cholesterol/HDL-cholesterol ratios and the ATP-III 10-year risk percent decreased significantly more (P < 0.05) in the olive oil-group after BMI, energy and alcohol intakes were adjusted.
  
  
  CONCLUSIONS
  Data suggest that although Simvastatin is a very effective hypolipemic drug, olive oil-diets in preference to sunflower oil-diets must be consumed in patients with high cardiovascular risk.
authors.affiliation: Departamento de Nutrición y Bromatología I (Nutrición), Facultad de Farmacia, Universidad Complutense de Madrid, Madrid, Spain. frasan@farm.ucm.es
authors.forename: F J
authors.initials: FJ
authors.lastname: Sánchez-Muniz
authors.forename: S
authors.initials: S
authors.lastname: Bastida
authors.forename: O
authors.initials: O
authors.lastname: Gutiérrez-García
authors.forename: A
authors.initials: A
authors.lastname: Carbajal
mesh_terms: D000924:Anticholesteremic Agents / Q000494:pharmacology*; D002318:Cardiovascular Diseases / Q000209:etiology / Q000517:prevention & control*; D004032:Diet; D005500:Follow-Up Studies; D018565:Food-Drug Interactions; D006801:Humans; D006937:Hypercholesterolemia / Q000150:complications / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D000069463:Olive Oil; D010938:Plant Oils; D012307:Risk Factors; D019821:Simvastatin / Q000494:pharmacology*; D000074242:Sunflower Oil
chemical_list: D000924:Anticholesteremic Agents; D000069463:Olive Oil; D010938:Plant Oils; D000074242:Sunflower Oil; D019821:Simvastatin