title: Genetic lesions in chronic lymphocytic leukemia: clinical implications.
abstract: OBJECTIVE
  To analyze recent scientific contributions correlating genetic lesions with clinical features in chronic lymphocytic leukemia (CLL).
  
  
  RESULTS
  Genetic abnormalities are increasingly important to understand not only CLL biology but also other aspects such as its epidemiology, diagnosis, prognosis, and clinical evolution.
  
  
  CONCLUSIONS
  Genetic abnormalities provide important clues in understanding the clinical and biologic heterogeneity of CLL, assessing the individual risk of each patient with this form of leukemia and also predicting response to therapy.
authors.affiliation: Institute of Hematology and Oncology, Department of Hematology, Hospital Clinic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Villarroel, Barcelona, Spain. emontse@clinic.ub.es
authors.forename: Emili
authors.initials: E
authors.lastname: Montserrat
authors.forename: Carol
authors.initials: C
authors.lastname: Moreno
mesh_terms: D020869:Gene Expression Profiling; D015973:Gene Expression Regulation, Leukemic; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D017404:In Situ Hybridization, Fluorescence; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000175:diagnosis* / Q000235:genetics* / Q000628:therapy; D035683:MicroRNAs / Q000235:genetics; D011379:Prognosis; D016896:Treatment Outcome; D051746:ZAP-70 Protein-Tyrosine Kinase / Q000235:genetics
chemical_list: D007143:Immunoglobulin Heavy Chains; D035683:MicroRNAs; D051746:ZAP-70 Protein-Tyrosine Kinase