Close correlation between anxiety, depression, and asthma control.
BACKGROUND
We investigated the correlation between patients' characteristics, including anxiety and depression, and the level of asthma control evaluated by asthma control test (ACT), a self-administered validated questionnaire.


METHODS
This is a cross-sectional study on asthmatic outpatients of three Italian hospitals. Demographic data, spirometry, anxiety and depression scores as well as the level of asthma control from 315 patients were collected.


RESULTS
Patients with poorly controlled asthma were more frequently women, older, with a worse pulmonary function, obese, more anxious and/or more depressed. Four different independent factors associated with poor asthma control evaluated by ACT have been found: FEV(1)<60% (odds ratio, OR: 6.52), anxiety (OR: 3.76), age > or =65 years (OR: 2.69), and depression (OR: 2.45). The presence of anxiety and depression was associated with a higher healthcare utilization. Finally, we found a high level of agreement between ACT and multidimensional GINA approach in evaluating asthma control, with a concordance in 239 patients (81% of the population).


CONCLUSIONS
There is a close correlation between anxiety and depression, and a poor asthma. A better understanding of this association may have major clinical implications, mainly in patients with poor controlled asthma in whom the presence of anxiety and depression should be investigated.
Di Marco
Fabiano
F
Clinica di Malattie dell'Apparato Respiratorio, Ospedale San Paolo, Università degli Studi di Milano, Milano, Italy. fabiano.dimarco@unimi.it
Verga
Massimo
M
Santus
Pierachille
P
Giovannelli
Francesca
F
Busatto
Paolo
P
Neri
Margherita
M
Girbino
Giuseppe
G
Bonini
Sergio
S
Centanni
Stefano
S
D000328:Adult; D018927:Anti-Asthmatic Agents / Q000627:therapeutic use*; D001008:Anxiety Disorders / Q000150:complications*; D001249:Asthma / Q000188:drug therapy* / Q000523:psychology; D003430:Cross-Sectional Studies; D003866:Depressive Disorder / Q000150:complications*; D005260:Female; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010349:Patient Compliance; D011788:Quality of Life; D012648:Self Care / Q000379:methods; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires
D018927:Anti-Asthmatic Agents