title: [Effect of preemptive analgesia with flurbiprofen axetil on patient-controlled intravenous analgesia with tramadol in patients undergoing postburn plastic surgery].
abstract: OBJECTIVE
  To observe the preemptive analgesic effect of flurbiprofen axetil for post-operative pain relief.
  
  
  METHODS
  Sixty ASA class I or II patients undergoing postburn plastic surgery were randomly assigned into two groups to receive intravenous administration of 100 mg flurbiprofen axetil (group F, n=30) and 10 ml intravenous saline (group C, n=30) 30 min before surgery. After the operation, all the patients received patient-controlled intravenous analgesia (PCIA) with tramadol for pain relief. The postoperative analgesic effect was assessed by visual analog scales (VAS) at 1, 2, 4, 8, 12 and 24 h after surgery, with tramadol requirements and the adverse effects were recorded.
  
  
  RESULTS
  At 1, 2, 4, and 8 h after the operation, the patients in group F showed significantly lowered VAS scores as compared with the patients in group C (P<0.05). The requirement of tramadol was also significantly less in group F than in group C (182.9-/+37.4 vs 227.3-/+49.8 mg, P<0.05). No significant difference was found in the adverse effects between the two groups.
  
  
  CONCLUSIONS
  Flurbiprofen axetil can produce preemptive analgesia and reduce the tramadol dose during postoperative PCIA in patients undergoing postburn plastic operations.
authors.affiliation: Department of Anesthesiology, Twelfth People's Hospital, Guangzhou, China. gzjc12h@163.com
authors.forename: Ji-Can
authors.initials: JC
authors.lastname: Lu
authors.forename: Xue-Feng
authors.initials: XF
authors.lastname: Zhang
authors.forename: Chao
authors.initials: C
authors.lastname: Liu
mesh_terms: D000328:Adult; D016058:Analgesia, Patient-Controlled / Q000379:methods; D000701:Analgesics, Opioid / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D002056:Burns / Q000601:surgery*; D005260:Female; D005480:Flurbiprofen / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D010149:Postoperative Pain / Q000517:prevention & control*; D013518:Surgery, Plastic; D013997:Time Factors; D014147:Tramadol / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: D000701:Analgesics, Opioid; D000894:Anti-Inflammatory Agents, Non-Steroidal; D014147:Tramadol; D005480:Flurbiprofen; C504422:flurbiprofen axetil