title: [Estimation of oxidation-reduction balance in subjects with metabolic syndrome together with or without periodontal diseases].
abstract: Dysfunction of vascular endothelium, which lies at the bottom of atherosclerosis, mainly is caused by toxic free radicals. The aim of the study was to estimate oxidation-reduction balance in subjects with metabolic syndrome (MS).
  
  
  METHODS
  The study comprised 98 subjects (39 men and 59 women) who were divided into three groups: I group--studied: 52 subjects with MS and periodontal diseases (19 men and 33 women in mean age 48 +/- 4.2 years); II group--reference: 21 subjects with MS and without periodontal diseases (10 men and 11 women in mean age 37 +/- 4.8 years); III group--control: 25 healthy subjects and without periodontal diseases (10 men and 15 women in mean age 35 +/- 4.8 years). Metabolic syndrome was defined according to IDF criteria. To estimate oxidation-reduction balance we evaluated: TBARS concentration in red blood cells and plasma, total antioxidant status (TAS), activity of SOD-1, CAT, GSH-Px in red blood cells.
  
  
  RESULTS
  In subjects with MS in comparison with control group, we observed increase of TBARS concentration in red blood cells and plasma, decrease of TAS and increase of activity of SOD-1, CAT, GSH-Px in red blood cells.
  
  
  CONCLUSIONS
  Periodontal diseases escalate disturbances of oxidation-reduction balance observed in subjects with metabolic syndrome. Medicaments with additive antioxidant effect can reduce disturbances of oxidation-reduction balance observed in subjects with metabolic syndrome.
authors.affiliation: Uniwersytet Medyczny w Łodzi, Zakład Neurologii i Zaburzeń Czynnościowych Narzadu Zucia Szpitala Klinicznego nr 6.
authors.forename: Marcin
authors.initials: M
authors.lastname: Kowalski
authors.forename: Ewa
authors.initials: E
authors.lastname: Brocka
authors.forename: Marcin
authors.initials: M
authors.lastname: Barylski
authors.forename: Edward
authors.initials: E
authors.lastname: Kowalczyk
authors.forename: Lucjan
authors.initials: L
authors.lastname: Pawlicki
authors.forename: Jan
authors.initials: J
authors.lastname: Kowalski
mesh_terms: D000328:Adult; D015897:Comorbidity; D004912:Erythrocytes / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000453:epidemiology*; D008875:Middle Aged; D010084:Oxidation-Reduction; D010510:Periodontal Diseases / Q000453:epidemiology*; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism*
chemical_list: D017392:Thiobarbituric Acid Reactive Substances