title: Chemical examination of the Sponge Phycopsis sp.
abstract: Two new compounds 7alpha,8alpha-epoxy theonellin isothiocyanate (1) and 5alpha,8alpha-epidioxyergosta-6Z,22Z,25-trien-3beta-ol (2) along with two known compounds, theonellin isothiocyanate (3) and theonellin formamide (4) have been isolated from the sponge Phycopsis sp. Compound 2 showed cytotoxic activity against HL-60 and U937 human cancer cell lines with IC(50) values of 5.96+/-0.02 and 31.72+/-0.55 microg/ml, respectively.
authors.affiliation: Natural Products Laboratory, Organic Chemistry Division-I, Indian Institute of Chemical Technology, India.
authors.forename: Chinni Mahesh
authors.initials: CM
authors.lastname: Kondempudi
authors.forename: Rajaram
authors.initials: R
authors.lastname: Singanaboina
authors.forename: Narasimhulu
authors.initials: N
authors.lastname: Manchala
authors.forename: Venu Gopal
authors.initials: VG
authors.lastname: Gunda
authors.forename: Venkateswara Rao
authors.initials: VR
authors.lastname: Janapala
authors.forename: Venkateswarlu
authors.initials: V
authors.lastname: Yenamandra
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D045744:Cell Line, Tumor; D004146:Dioxanes / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D004354:Drug Screening Assays, Antitumor; D004875:Ergosterol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D006801:Humans; D017879:Isothiocyanates / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D009682:Magnetic Resonance Spectroscopy; D011161:Porifera / Q000737:chemistry*
chemical_list: C545015:7alpha,8alpha-epoxy theonellin isothiocyanate; D000970:Antineoplastic Agents; D004146:Dioxanes; D017879:Isothiocyanates; C083899:axinylsterol; D004875:Ergosterol