title: The correspondence between coronary arterial wall strain and histology in a porcine model of atherosclerosis.
abstract: Atherosclerotic plaque rupture is the leading cause of mortality in cardiovascular disease. Intravascular ultrasound (IVUS) imaging is a powerful clinical technique that provides real-time cross-sectional images of the arterial wall and atherosclerotic plaques. However, it does not provide sufficient information about the histological composition of plaques to characterize their vulnerability. Arterial wall strain measurements may provide insights into plaque composition and vulnerability, complementing the information directly available in the IVUS echogram. We have developed a method to measure the transverse arterial wall strain tensor in response to luminal pressure change, by registering IVUS images acquired at different pressures. This method has been validated by using IVUS images with simulated motion and IVUS images of a vessel phantom. In this study, we further evaluate the method by assessing the correspondence of the calculated strain distribution and the histological composition of atherosclerotic coronary arteries from Sinclair miniature pigs following 12 months of a high fat diet. The images were acquired in situ using a clinical IVUS system and under computer-controlled pressurization. After image acquisition, the artery segments were fixed for histology to identify plaque components. The strain distributions were aligned with the corresponding histological sections. The stiffness of various components of the lesion, inferred from the wall strain distribution, was consistent with the tissue composition seen in the histological cross-sections. These findings suggest that strain measurements from IVUS are promising for assessing plaque vulnerability.
authors.affiliation: Department of Biomedical Engineering, Duke University, Durham, NC, USA.
authors.forename: Yun
authors.initials: Y
authors.lastname: Liang
authors.forename: Hui
authors.initials: H
authors.lastname: Zhu
authors.forename: Morton H
authors.initials: MH
authors.lastname: Friedman
mesh_terms: D000818:Animals; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology*; D003331:Coronary Vessels / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology*; D004195:Disease Models, Animal; D055119:Elastic Modulus; D054459:Elasticity Imaging Techniques / Q000379:methods*; D006801:Humans; D013223:Statistics as Topic; D013314:Stress, Mechanical; D013552:Swine