title: [Alveolar hemorrhage in pulmonary-renal syndrome anti-SCL/70 and anti-MPO-ANCA positive].
abstract: We describe a case of pulmonary-renal syndrome on autoimmune basis, with alveolar hemorrhage and worsening renal failure. The patient was positive for anti-MPO and anti-SCL/70. Immunosuppressive therapy was effective to treat the pulmonary condition, but chronic renal failure emerged. The clinical condition did not improve after plasmapheresis, thus chronic dialysis was required.
authors.affiliation: Laboratorio di Analisi, Ospedale Fatebenefratelli, Milano, Italia. caterina.defendenti@fbf.milano.it
authors.forename: Caterina
authors.initials: C
authors.lastname: Defendenti
authors.forename: Maria Francesca
authors.initials: MF
authors.lastname: Spina
authors.forename: Aldo
authors.initials: A
authors.lastname: Castiglione
authors.forename: Fabiola
authors.initials: F
authors.lastname: Atzeni
authors.forename: Antonio
authors.initials: A
authors.lastname: Miadonna
authors.forename: Mariella
authors.initials: M
authors.lastname: Saudelli
authors.forename: Giacinto
authors.initials: G
authors.lastname: Guercilena
authors.forename: Piercarlo
authors.initials: P
authors.lastname: Sarzi-Puttini
mesh_terms: D000328:Adult; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood*; D000974:Antibodies, Antinuclear / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D004264:DNA Topoisomerases, Type I; D005260:Female; D015432:Glomerulonephritis, Membranoproliferative / Q000097:blood / Q000150:complications / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D006470:Hemorrhage / Q000276:immunology* / Q000628:therapy; D006801:Humans; D007155:Immunologic Factors / Q000097:blood*; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008171:Lung Diseases / Q000097:blood / Q000150:complications / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D017563:Lung Diseases, Interstitial / Q000276:immunology; D009687:Nuclear Proteins / Q000097:blood*; D010956:Plasmapheresis; D011650:Pulmonary Alveoli / Q000473:pathology; D006435:Renal Dialysis / Q000379:methods; D012595:Scleroderma, Systemic / Q000150:complications; D013577:Syndrome; D016896:Treatment Outcome
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D000974:Antibodies, Antinuclear; D015415:Biomarkers; D007155:Immunologic Factors; D007166:Immunosuppressive Agents; D009687:Nuclear Proteins; C048100:Scl 70 antigen, human; D004264:DNA Topoisomerases, Type I