Primary renal lymphoma: report of three new cases and literature review.
OBJECTIVE
We report the cases of three patients with primary renal lymphoma. Diagnosis and subsequent treatment are discussed.


METHODS
The literature on the origin, epidemiology, clinical presentation, diagnosis, treatment and prognosis of primary renal lymphoma was reviewed.


RESULTS
The first patient was diagnosed after radical nephrectomy and subsequently was given six cycles of CVP (cyclophosphamide, vincristine, prednisone). The diagnosis of the second patient was established by renal biopsy, and the patient received six cycles of CHOP (cyclophosphamide, adriamycin, vincristine and predisone). The last patient had a lymphoma, secondary to immunosuppression, in a transplanted kidney. In this case transplant nephrectomy sufficed to cure the patient's lymphoma. All patients had B-cell non-Hodgkin lymphoma (an extrarenal origin was ruled out by bone marrow biopsy), and were disease-free 15 months, 7 months, and 6.5 years after diagnosis, respectively.


CONCLUSIONS
Primary renal lymphoma is rare. Diagnosis is established by renal biopsy, although it often presents as a mass simulating renal cell cancer and diagnosis is obtained after radical nephrectomy. Treatment consists of chemotherapy (CHOP). associated with rituximab.
Vázquez Alonso
Fernando
F
Department of Urology, University Hospital Virgen de las Nieves, Granada, Spain. fernando.vazquez.alonso.sspa@juntadeandalucia.es
Sánchez Ramos
Carolina
C
Vicente Prados
Francisco Javier
FJ
Pascual Geler
Manrique
M
Ruiz Carazo
Eduardo
E
Becerra Massare
Patricia
P
Funes Padilla
Carlos
C
Rodríguez Herrera
Francisco
F
Cózar Olmo
José Manuel
JM
Tallada Buñuel
Miguel
M
D000368:Aged; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000175:diagnosis / Q000628:therapy; D016393:Lymphoma, B-Cell / Q000175:diagnosis / Q000628:therapy; D008297:Male; D008875:Middle Aged