title: Centrifugal lipodystrophy of the scalp presenting with an arch-form alopecia: a 10-year follow-up observation.
abstract: We describe a 10-year follow-up observation of progressive arch-form alopecia caused by centrifugal lipodystrophy (CLD) in a Japanese boy. A 2.5-year-old boy developed a slightly depressed lesion demarcated by a horseshoe-shaped erythematous border on his right neck, which then extended to the scalp. Four years later, arch-form alopecia became apparent in the right temporal region along with an erythematous border. The arch-form alopecia gradually expanded centrifugally, leaving a slight residual depression, but hair regrowth was seen within the area of alopecia. Histological examination of the erythematous border revealed non-specific inflammatory changes in the subcutaneous fat. Magnetic resonance imaging findings revealed a loss of subcutaneous fat inside the lesion. The alopecia continuously extended until he was 12 years old, but, thereafter, expansion ceased and hair regrowth gradually occurred in the arch-form alopecia. A linear non-hairy lesion 5 cm in length still remained when he was 13 years old. CLD might involve the scalp and cause linear, arch-form alopecia.
authors.affiliation: Department of Dermatology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima City, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Fukumoto
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Kubo
authors.forename: Minako
authors.initials: M
authors.lastname: Saito
authors.forename: Seiji
authors.initials: S
authors.lastname: Arase
mesh_terms: D000293:Adolescent; D000367:Age Factors; D000505:Alopecia / Q000473:pathology*; D006644:Histiocytes / Q000473:pathology; D006801:Humans; D008060:Lipodystrophy / Q000473:pathology*; D008214:Lymphocytes / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D015434:Panniculitis / Q000473:pathology; D012536:Scalp Dermatoses / Q000473:pathology*