When Shigella tells the cell to hang on.
OspE, a Shigella type III effector binds to integrin-like kinase and enhances cell adhesion to better disseminate and colonize the intestinal epithelium. Because of the existence of OspE orthologues in other enteropathogens such as enteropathogenic Escherichia coli or Salmonella sp., maintenance of cell adhesion appears as a widespread strategy for bacteria that interact with the intestinal epithelium.
Van Nhieu
Guy Tran
GT
Inserm U971, Unité de Communications Intercellulaires et Infections Microbiennes, Collège de France, 11, Place Marcelin Berthelot, 75005 Paris Cedex, France.
Guignot
Julie
J
D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D022001:Focal Adhesions / Q000382:microbiology; D015964:Gene Expression Regulation, Bacterial; D054884:Host-Pathogen Interactions; D006801:Humans; D012760:Shigella / Q000235:genetics / Q000472:pathogenicity / Q000502:physiology*
D001426:Bacterial Proteins