title: Small-colony variant selection as a survival strategy for Staphylococcus aureus in the presence of Pseudomonas aeruginosa.
abstract: Previously it has been demonstrated that Staphylococcus aureus is sensitive toward Pseudomonas-secreted exotoxins, which preferentially target the electron transport chain in staphylococci. Here it is shown that a subpopulation of S. aureus survives these respiratory toxins of Pseudomonas aeruginosa by selection of the small-colony variant (SCV) phenotype. Purified pyocyanin alone causes the same effect. A hemB mutant of S. aureus survives cocultivation with P. aeruginosa without a decrease in CFU.
authors.affiliation: Institute of Microbial Genetics, University of Tübingen, 72076 Tübingen, Germany.
authors.forename: Lalitha
authors.initials: L
authors.lastname: Biswas
authors.forename: Raja
authors.initials: R
authors.lastname: Biswas
authors.forename: Martin
authors.initials: M
authors.lastname: Schlag
authors.forename: Ralph
authors.initials: R
authors.lastname: Bertram
authors.forename: Friedrich
authors.initials: F
authors.lastname: Götz
mesh_terms: D000898:Antibiosis; D050296:Microbial Viability; D011550:Pseudomonas aeruginosa / Q000254:growth & development / Q000502:physiology*; D011710:Pyocyanine / Q000633:toxicity; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development / Q000502:physiology*; D013312:Stress, Physiological
chemical_list: D011710:Pyocyanine