Case-control Study of methylenetetrahydrofolate reductase mutations and hyperhomocysteinemia and risk of stroke.
The association of factor V-Leiden and methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C mutations with stroke was investigated in 118 patients with stroke and 120 control subjects. MTHFR 677TT (P < .001) and 1298CC (P < .001), but not factor V-Leiden (P = .179), genotypes were associated with stroke. The C677T but not A1298C MTHFR mutation was associated with elevated homocysteine levels in patients and control subjects. In addition to hypertension, the significant predictors for stroke were MTHFR 677CT and TT and A1298CC genotypes, together with hyperhomocysteinemia, indicating a synergistic effect of MTHFR mutations with elevated homocysteine and other risk factors in pathogenesis of stroke.
Almawi
Wassim Y
WY
College of Medicine and Medical Sciences, Arabian Gulf University, Manama, Bahrain. wassim@agu.edu.bh
Khan
Abdulmajeed
A
Al-Othman
Sara S
SS
Bakhiet
Moiz
M
D016022:Case-Control Studies; D004252:DNA Mutational Analysis; D005165:Factor V / Q000235:genetics; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D005838:Genotype; D006710:Homocysteine / Q000097:blood; D006801:Humans; D020138:Hyperhomocysteinemia / Q000453:epidemiology* / Q000235:genetics* / Q000378:metabolism; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D009154:Mutation / Q000235:genetics*; D012307:Risk Factors; D020521:Stroke / Q000453:epidemiology* / Q000235:genetics* / Q000378:metabolism; D015854:Up-Regulation / Q000235:genetics
D005819:Genetic Markers; C095381:factor V Leiden; D006710:Homocysteine; D005165:Factor V; D042965:Methylenetetrahydrofolate Reductase (NADPH2)