Plasmid-mediated fluoroquinolone efflux pump gene, qepA, in Escherichia coli clinical isolates in Korea.
The qepA gene was detected in 4 (0.6%) of 621 nonduplicate Escherichia coli clinical isolates collected from blood cultures in Korea. Three of the 4 qepA-positive isolates contained bla(CTX-M-14) and/or bla(TEM-1) genes, but not the E8700 isolate. The qepA gene was successfully transferred and conferred resistance to hydrophilic quinolones, such as norfloxacin and ciprofloxacin, in the recipient. The gene was located in part of IS26. Two isolates were linked to the truncated rmtB gene.
Kim
Eun Sil
ES
Department of Infectious Diseases, Asan Medical Center and Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea.
Jeong
Jin-Yong
JY
Choi
Sang-Ho
SH
Lee
Sang-Oh
SO
Kim
Sung-Han
SH
Kim
Mi-Na
MN
Woo
Jun Hee
JH
Kim
Yang Soo
YS
D016470:Bacteremia / Q000097:blood / Q000382:microbiology; D001426:Bacterial Proteins / Q000235:genetics; D004754:Enterobacter / Q000235:genetics; D004756:Enterobacteriaceae Infections / Q000097:blood / Q000382:microbiology; D004926:Escherichia coli / Q000235:genetics* / Q000302:isolation & purification / Q000378:metabolism; D004927:Escherichia coli Infections / Q000097:blood / Q000382:microbiology*; D029968:Escherichia coli Proteins / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D007711:Klebsiella pneumoniae / Q000235:genetics; D007723:Korea; D010957:Plasmids / Q000235:genetics; D016133:Polymerase Chain Reaction
D001426:Bacterial Proteins; D029968:Escherichia coli Proteins; C524438:QepA protein, E coli