A multi-institutional acute gastrointestinal toxicity analysis of anal cancer patients treated with concurrent intensity-modulated radiation therapy (IMRT) and chemotherapy.
Using previous dosimetric analysis methods, we identified the volume of bowel receiving 30 Gy (V(30)) correlated with acute gastrointestinal (GI) toxicity in anal cancer patients treated with intensity-modulated radiation therapy and concurrent chemotherapy. For V(30)>450 cc and < or =450 cc, acute GI toxicity was 33% and 8%, respectively (p=0.003).
Devisetty
Kiran
K
Department of Radiation and Cellular Oncology, University of Chicago, IL, USA.
Mell
Loren K
LK
Salama
Joseph K
JK
Schomas
David A
DA
Miller
Robert C
RC
Jani
Ashesh B
AB
Roeske
John C
JC
Aydogan
Bulent
B
Chmura
Steven J
SJ
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001005:Anus Neoplasms / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D041981:Gastrointestinal Tract / Q000187:drug effects* / Q000528:radiation effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage; D050397:Radiotherapy, Intensity-Modulated / Q000009:adverse effects*
D016685:Mitomycin; D005472:Fluorouracil