Molecular diversity of anticoagulants from haematophagous animals.
To obtain blood meals, haematophagous animals are armed with potent pharmacological molecules to overcome several of their hosts' response systems. Among them, a large number of exogenous anticoagulants which target the haemostatic system have been identified and characterised. Studies on these anticoagulants have expanded our knowledge on the blood coagulation system, and provided a valuable source of antithrombotic therapeutic agents. Advances in genomic, transcriptomic, structural and proteomic tools greatly accelerated the discovery and analysis of the exogenous anticoagulants in recent years. The molecular diversity observed in these molecules is huge and is constantly expanding. In this review, we will provide an overview on the structure, function and mechanism of the exogenous anticoagulants from haematophagous animals and rationalise their molecular diversity.
Koh
Cho Yeow
CY
Department of Biological Sciences, Faculty of Science, National University of Singapore, Science Drive 4, Singapore 117543, Singapore.
Kini
R Manjunatha
RM
D000595:Amino Acid Sequence; D000818:Animals; D000925:Anticoagulants / Q000737:chemistry* / Q000378:metabolism; D001920:Bradykinin / Q000502:physiology; D006487:Hemostasis; D006629:Hirudins / Q000737:chemistry; D019476:Insect Proteins / Q000378:metabolism; D007447:Invertebrate Hormones / Q000378:metabolism; D008958:Models, Molecular; D008968:Molecular Conformation; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000502:physiology; D017434:Protein Structure, Tertiary; D017386:Sequence Homology, Amino Acid; D013329:Structure-Activity Relationship; D013917:Thrombin / Q000737:chemistry
D000925:Anticoagulants; D006629:Hirudins; D019476:Insect Proteins; D007447:Invertebrate Hormones; D010446:Peptide Fragments; C517571:chimadanin; C053155:antistasin; C079000:bradykinin (1-5); D013917:Thrombin; D001920:Bradykinin