Multiple, independent, identical IS6110 insertions in Mycobacterium tuberculosis PPE genes.
IS6110 is a transposable element found in Mycobacterium tuberculosis complex members. Regions of preferential IS6110 integration occur within the M. tuberculosis genome but the element has not previously been shown to exhibit any sequence-specific integration preferences. Here we provide evidence for multiple independent IS6110 insertions into identical, or near-identical, positions within the highly homologous 5' region of 3 PPE genes.
McEvoy
Christopher R E
CR
DST/NRF Centre of Excellence for Biomedical Tuberculosis Research/MRC Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Faculty of Health Sciences, Stellenbosch University, Tygerberg, South Africa. cmcevoy@sun.ac.za
Warren
Robin M
RM
van Helden
Paul D
PD
Gey van Pittius
Nicolaas C
NC
D000942:Antigens, Bacterial / Q000235:genetics*; D001426:Bacterial Proteins / Q000235:genetics*; D001483:Base Sequence; D004251:DNA Transposable Elements / Q000235:genetics; D004269:DNA, Bacterial / Q000235:genetics; D006801:Humans; D016254:Mutagenesis, Insertional; D009169:Mycobacterium tuberculosis / Q000235:genetics* / Q000276:immunology; D017422:Sequence Analysis, DNA
D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D004251:DNA Transposable Elements; D004269:DNA, Bacterial