B cell receptor and BAFF receptor signaling regulation of B cell homeostasis.
B lymphocyte homeostasis depends on tonic and induced BCR signaling and receptors sensitive to trophic factors, such as B cell-activating factor receptor (BAFF-R or BR3) during development and maintenance. This review will discuss growing evidence suggesting that the signaling mechanisms that maintain B cell survival and metabolic fitness during selection at transitional stages and survival after maturation rely on cross-talk between BCR and BR3 signaling. Recent findings have also begun to unravel the molecular mechanisms underlying this crosstalk. In this review I also propose a model for regulating the amplitude of BCR signaling by a signal amplification loop downstream of the BCR involving Btk and NF-kappaB that may facilitate BCR-dependent B cell survival as well as its functional coupling to BR3 for the growth and survival of B lymphocytes.
Khan
Wasif N
WN
Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA. wnkhan@med.miami.edu
D053265:B-Cell Activation Factor Receptor / Q000502:physiology*; D016175:B-Lymphocyte Subsets / Q000166:cytology*; D006706:Homeostasis; D006801:Humans; D020239:Receptor Cross-Talk; D011947:Receptors, Antigen, B-Cell / Q000502:physiology*; D015398:Signal Transduction
D053265:B-Cell Activation Factor Receptor; D011947:Receptors, Antigen, B-Cell