Profound teratospermia does not influence sex chromosomal aneuploidy rate in in vitro fertilization-preimplantation genetic diagnosis cycles.
Because spermatocyte meiotic error results in embryonic sex chromosomal aneuploidy, it is speculated that teratospermia correlates with increased embryonic sex chromosomal abnormalities. Our findings contradict this theory, suggesting that morphology does not correlate with sex chromosomal genotype.
Dayal
Molina B
MB
Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, Fertility and IVF, Washington, DC, USA. Mdayal@mfa.gwu.edu
Gindoff
Paul R
PR
Zarek
Shvetha
S
Peak
Douglas
D
Dubey
Anil
A
Frankfurter
David
D
D000293:Adolescent; D000328:Adult; D000782:Aneuploidy; D006063:Chorionic Gonadotropin / Q000627:therapeutic use*; D004958:Estradiol / Q000097:blood; D005260:Female; D005300:Fertility Agents, Female / Q000627:therapeutic use; D005307:Fertilization in Vitro / Q000706:statistics & numerical data*; D005640:Follicle Stimulating Hormone / Q000097:blood; D005838:Genotype; D006801:Humans; D016729:Leuprolide / Q000627:therapeutic use; D008297:Male; D008423:Maternal Age; D054315:Oocyte Retrieval / Q000379:methods; D010062:Ovulation Induction / Q000379:methods; D010331:Paternal Age; D011247:Pregnancy; D019836:Preimplantation Diagnosis / Q000379:methods*; D012729:Sex Chromosome Aberrations / Q000706:statistics & numerical data*; D013094:Spermatozoa / Q000002:abnormalities*; D017211:Treatment Failure
D006063:Chorionic Gonadotropin; D005300:Fertility Agents, Female; D004958:Estradiol; D005640:Follicle Stimulating Hormone; D016729:Leuprolide