Palladium- and copper-catalyzed solution phase synthesis of a diverse library of isoquinolines.
The solution-phase synthesis of a 111 member isoquinoline library is described. The isoquinoline scaffold has been accessed through the palladium- and copper-catalyzed cyclization of iminoalkynes and the palladium-catalyzed iminoannulation of internal alkynes, followed by diversification of hydroxyl functionality where it is present.
Roy
Sudipta
S
Department of Chemistry, Iowa State University, Ames, Iowa 50011, USA.
Roy
Sujata
S
Neuenswander
Benjamin
B
Hill
David
D
Larock
Richard C
RC
D002384:Catalysis; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D008970:Molecular Weight; D009942:Organometallic Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D054852:Small Molecule Libraries; D012996:Solutions; D013237:Stereoisomerism
D007546:Isoquinolines; D009942:Organometallic Compounds; D054852:Small Molecule Libraries; D012996:Solutions; D010165:Palladium; D003300:Copper