IKKepsilon: a bridge between obesity and inflammation.
Obesity leads to tissue inflammation and insulin resistance, which are features of metabolic diseases such as type 2 diabetes. Chiang et al. (2009) now show that the IkappaB kinase IKKepsilon is an important link between obesity and inflammation and may be a new therapeutic target for treating obesity-related metabolic diseases.
Olefsky
Jerrold M
JM
Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA. jolefsky@ucsd.edu
D000818:Animals; D006801:Humans; D051550:I-kappa B Kinase / Q000378:metabolism*; D007249:Inflammation / Q000378:metabolism*; D051379:Mice; D009765:Obesity / Q000276:immunology / Q000378:metabolism*
D051550:I-kappa B Kinase