Effect of training judo in the competition period on the plasmatic levels of leptin and pro-inflammatory cytokines in high-performance male athletes.
The purpose this study was to evaluate the effect of training judo in the competition period on the plasmatic levels of bioactive molecules in high-performance male athletes. The subjects were divided into two groups, a trained group with 11 judokas and a nontrained group also with 11 subjects. Blood samples obtained 60 h after training to measure plasma tumor necrosis factor (TNF-alpha), interleukin-6 (IL-6), monocyte chemotactic protein 1 (MCP-1), and leptin levels. The trained group presented a significant reduction in the percentage of fat and fat mass and an increase in the lumbar and lower limbs traction forces and the maximum VO(2) when compared to the nontrained group. There was no significant difference in the serum concentrations of TNF-alpha and IL-6 between the two groups. The trained group presented a lower concentration of leptin, both as absolute values as well as relative to the percentage of fat, and a higher concentration of MCP-1, in relation to the nontrained group. Our results suggest an adaptation in the capacity of synthesizing and secreting leptin in response to chronic stress in judo, what suggests a neuro-hormonal adjustment that guarantees the efficiency of metabolism. The changes of MCP-1 indicated a possible inflammatory state.
de Oliveira
Donizete Cicero Xavier
DC
Post Graduate Program-Human Movement Sciences Institute of Physical Activity and Sport Sciences, Cruzeiro do Sul University São Paulo, 868 Galvão Bueno Street, São Paulo 01506-000, Brazil.
Rossano Procida
Izildinha
I
das Neves Borges-Silva
Cristina
C
D018932:Chemokine CCL2 / Q000097:blood*; D015444:Exercise / Q000502:physiology*; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D020738:Leptin / Q000097:blood*; D008297:Male; D016139:Martial Arts / Q000502:physiology*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*; D055815:Young Adult
D018932:Chemokine CCL2; D015850:Interleukin-6; D020738:Leptin; D014409:Tumor Necrosis Factor-alpha