Recurrent, multifocal Mycobacterium avium-intercellulare infection in a patient with interferon-gamma autoantibody.
We describe a patient who experienced severe osteomyelitis because of Mycobacterium avium-intercellulare infection and high-titered autoantibodies against interferon-gamma. In addition to antimycobacterial chemotherapy, we treated our patient with plasmapheresis and cyclophosphamide. The treatment induced a remission after 3 years of follow-up.
Baerlecken
N
N
Clinic for Immunology and Rheumatology, Medical School of Hanover, Carl-Neuberg-Str 1, 30625 Hanover, Germany. baerlecken.niklas@mh-hannover.de
Jacobs
R
R
Stoll
M
M
Schmidt
R E
RE
Witte
T
T
D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use; D001323:Autoantibodies / Q000097:blood*; D001327:Autoimmune Diseases / Q000150:complications*; D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007371:Interferon-gamma / Q000276:immunology*; D009164:Mycobacterium Infections / Q000188:drug therapy / Q000382:microbiology* / Q000628:therapy; D009162:Mycobacterium avium / Q000302:isolation & purification*; D010019:Osteomyelitis / Q000382:microbiology; D010956:Plasmapheresis; D012008:Recurrence
D000995:Antitubercular Agents; D001323:Autoantibodies; D007166:Immunosuppressive Agents; D007371:Interferon-gamma; D003520:Cyclophosphamide