Role of protein tyrosine nitration in neurodegenerative diseases and atherosclerosis.
Nitric oxide generates reactive nitrosative species, such as peroxynitrite (ONOO(-)) that may be involved in a number of diseases. ONOO(-) can mediate protein tyrosine nitration which causes structural changes of affected proteins and leads to their inactivation. Various proteomics and immunological methods including mass spectrometry combined with both liquid and 2-D PAGE, and immunodetection have been employed to identify and characterize nitrated proteins from pathological samples. This review presents the pahtobiological roles of the pathogenic posttranslational modification in neurodegenerative diseases and atherosclerosis.
Lee
Jung Rok
JR
Department of Molecular Biotechnology, Konkuk University, Seoul, Korea.
Kim
Jae Kyung
JK
Lee
Soo Jae
SJ
Kim
Kwang Pyo
KP
D000818:Animals; D050197:Atherosclerosis / Q000209:etiology* / Q000378:metabolism; D023201:CD40 Ligand / Q000502:physiology; D002318:Cardiovascular Diseases / Q000209:etiology / Q000378:metabolism; D006801:Humans; D019636:Neurodegenerative Diseases / Q000209:etiology* / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D011506:Proteins / Q000378:metabolism*; D040901:Proteomics; D011973:Receptors, LDL / Q000502:physiology; D014443:Tyrosine / Q000378:metabolism*
D011506:Proteins; D011973:Receptors, LDL; D023201:CD40 Ligand; D009569:Nitric Oxide; D014443:Tyrosine