Human papillomavirus in women with and without HIV-1 infection attending an STI clinic in Vitoria, Brazil.
We conducted a cross-sectional study in Vitória, Brazil, to assess the prevalence of human papillomavirus (HPV) infection in HIV-positive and HIV-negative women attending a sexually transmitted infection (STI)/AIDS clinic. We also investigated the presence of HPV genotypes and assessed covariates for HIV infection. Enrolled patients received a gynecological evaluation, and cervical scrape samples were collected for cytological analysis and HPV-DNA polymerase chain reaction (PCR). A blood sample was obtained to determine HIV status. HPV infection and squamous intraepithelial lesions were studied in 284 women, 112 (39.4%) HIV-positive women and 172 (60.5%) HIV-negative women. HPV-DNA was detected in 133 (46.8%). HIV-infected women were almost twice as likely to be concurrently infected with HPV than HIV-negative women (OR = 1.87 95% CI: 1.16-3.03). The high proportion of HPV detected among women attending an STI/AIDS clinic, particularly among HIV-infected women, proves the importance of screening this high-risk group in the hope of earlier detection and treatment of cervical intraepithelial neoplasia (CIN).
Coelho Lima
Bettina Moulin
BM
Nucleo de Doencas Infecciosas, Universidade Federal do Espirito Santo, Brazil.
Golub
Jonathan E
JE
Tonani Mattos
Adriana
A
Freitas
Luciana Bueno de
LB
Cruz Spano
Liliana
L
Espinosa Miranda
Angélica
A
D000328:Adult; D000554:Ambulatory Care Facilities; D001938:Brazil / Q000453:epidemiology; D003430:Cross-Sectional Studies; D004279:DNA, Viral / Q000032:analysis; D004522:Educational Status; D005260:Female; D005838:Genotype; D015658:HIV Infections / Q000453:epidemiology*; D015497:HIV-1; D006801:Humans; D016015:Logistic Models; D030361:Papillomavirus Infections / Q000453:epidemiology*; D015995:Prevalence; D012747:Sexual Partners; D002583:Uterine Cervical Neoplasms / Q000473:pathology; D014626:Vaginal Smears; D002578:Uterine Cervical Dysplasia / Q000473:pathology
D004279:DNA, Viral