title: The Elmo family forms an ancient group of actin-regulating proteins.
abstract: The Elmo protein family members are important mediators of small G protein activity, regulating actin-mediated processes such as chemotaxis and engulfment. Until recently,1 Elmo function has not been explored in professional phagocytes such as Dictyostelium discoideum. We discuss the significance of this family with respect to pathways that regulate Rac signaling, we present a comparison of Elmo proteins between representative taxa, and discuss our findings on ElmoA, one of six Elmo proteins found in D. discoideum.
authors.affiliation: Laboratory of Immunogenetics Imaging Facility; National Institutes of Health; Rockville, MD USA.
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Brzostowski
authors.forename: Petra
authors.initials: P
authors.lastname: Fey
authors.forename: Jianshe
authors.initials: J
authors.lastname: Yan
authors.forename: Nilgun
authors.initials: N
authors.lastname: Isik
authors.forename: Tian
authors.initials: T
authors.lastname: Jin