Kidneys from elderly deceased donors discarded for transplantation.
Although deceased donors older than 60 years of age (D > 60) are increasing in number, little information exists on the rate of discarded kidneys from these aged individuals. This study sought to analyze causes of discard of kidneys from D > 60. Since 1997, we have transplanted kidneys from D > 60 into elderly recipients after assessing their functional and anatomical viability. Among 3444 renal offers for transplantation between 1997 and 2005, 1967 (57%) came from D > 60. Of these, 1145 offers were discarded, because the kidney donor was not adequate (n = 470) or because there was no elderly recipient on our waiting list (n = 675). We also examined 1745 kidneys, 822 (47%) of which came from D > 60. The percentage of discarded kidneys due to macroscopic or microscopic alterations was 46% in the D > 60 group compared with 14.7% in the donor group younger than 60 years of age (D < 60; P < .01). We transplanted 443 kidneys from D > 60 (85 dual, 273 single) to 358 recipients of matching age and 900 kidneys from D < 60. Three-year death-censored actuarial graft survival rate was 83% for D > 60 compared with 89% for D < 60 transplant (P = not significant). In conclusion, kidneys from D > 60 were discarded for transplantation mainly because there was no elderly recipient on the waiting list and due to macroscopic or microscopic alterations. Given the increasing offer of kidneys from D > 60 and the good results of transplantation with these aged kidneys in elderly recipients, the indications for kidney transplantation should be expanded to include more of the elderly population on dialysis to the waiting list.
Andrés
A
A
Coordinación de Trasplantes and Servicios de Nefrologia and Urologia, Hospital 12 de Octubre, Madrid, Spain.
Polanco
N
N
Cebrian
M P
MP
Sol Vereda
M
M
Vazquez
S
S
Nuño
E
E
Bello
T
T
Gutierrez
E
E
Gonzalez
E
E
Praga
M
M
Morales
E
E
Morales
J M
JM
Leiva
O
O
Aguirre
F
F
Diaz
R
R
D000368:Aged; D002102:Cadaver; D006085:Graft Survival / Q000502:physiology; D006801:Humans; D007668:Kidney / Q000473:pathology; D016030:Kidney Transplantation / Q000592:standards / Q000706:statistics & numerical data*; D008875:Middle Aged; D018579:Patient Selection; D012189:Retrospective Studies; D014019:Tissue Donors / Q000706:statistics & numerical data*; D014850:Waiting Lists