Automated production of copper radioisotopes and preparation of high specific activity [(64)Cu]Cu-ATSM for PET studies.
(60)Cu and (64)Cu are useful radioisotopes for positron emission tomography (PET) radiopharmaceuticals and may be used for the preparation of promising agents for diagnosis and radiotherapy. In this study, the production and purification of (60/64)Cu starting from (60/64)Ni using a new automated system, namely Alceo, is described. A dynamic process for electrodeposition and dissolution of (60/64)Ni/(60/64)Cu was developed. Preliminary production yields of (60)Cu and (64)Cu were 400 and 300mCi, respectively. (64)Cu was used to radiolabel the hypoxia detection tracer ATSM with a specific activity of 2.2+/-1.3Ci/micromol.
Matarrese
Mario
M
Institute of Molecular Bioimaging and Physiology-CNR, University of Milano-Bicocca, San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milano, Italy. matarrese.mario@hsr.it
Bedeschi
Paolo
P
Scardaoni
Roberto
R
Sudati
Francesco
F
Savi
Annarita
A
Pepe
Annalisa
A
Masiello
Valeria
V
Todde
Sergio
S
Gianolli
Luigi
L
Messa
Cristina
C
Fazio
Ferruccio
F
D001331:Automation / Q000295:instrumentation; D056831:Coordination Complexes; D003301:Copper Radioisotopes / Q000737:chemistry*; D017357:Cyclotrons; D007554:Isotopes / Q000737:chemistry; D009532:Nickel / Q000737:chemistry; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000302:isolation & purification; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*; D013882:Thiosemicarbazones / Q000138:chemical synthesis* / Q000302:isolation & purification
D056831:Coordination Complexes; D003301:Copper Radioisotopes; D007554:Isotopes; D009942:Organometallic Compounds; D019275:Radiopharmaceuticals; D013882:Thiosemicarbazones; C089548:copper (II) diacetyl-di(N(4)-methylthiosemicarbazone); D009532:Nickel