Pharmacokinetic interaction of some antitubercular drugs with caraway: implications in the enhancement of drug bioavailability.
This study deals with the pharmacokinetic interaction of selected anti-TB drugs with a natural product (CC-1a) derived from caraway (Carum carvi, L.) seed. CC-1a, chemically standardized butanolic fraction, enhanced the plasma levels of rifampicin, pyrazinamide, and isoniazid in Wistar rat, resulting in increased bioavailability indices (C(max) and AUC) of the drugs. Moreover, a 40% reduced dose regimen of these drugs, which additionally contained CC-1a, was equivalent in terms of C(max) and AUC to a normal dose regimen. A permeation-enhancing property of CC-1a across small intestinal absorptive surface was found to be a contributing factor in its bioavailability enhancing profile.
Sachin
B S
BS
Division of Pharmacology, Indian Institute of Integrative Medicine (CSIR), (Formerly Regional Research Laboratory), Jammu-Tawi, India.
Monica
P
P
Sharma
S C
SC
Satti
N K
NK
Tikoo
M K
MK
Tikoo
A K
AK
Suri
K A
KA
Gupta
B D
BD
Johri
R K
RK
D000818:Animals; D000995:Antitubercular Agents / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001682:Biological Availability; D029974:Carum / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D004347:Drug Interactions; D005260:Female; D007408:Intestinal Absorption / Q000187:drug effects; D007413:Intestinal Mucosa / Q000187:drug effects / Q000378:metabolism; D007538:Isoniazid / Q000493:pharmacokinetics; D007583:Jejunum / Q000378:metabolism; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology; D011718:Pyrazinamide / Q000493:pharmacokinetics; D051381:Rats; D017208:Rats, Wistar; D012015:Reference Standards; D012293:Rifampin / Q000493:pharmacokinetics; D012639:Seeds / Q000737:chemistry; D012997:Solvents
D000995:Antitubercular Agents; D010936:Plant Extracts; D012997:Solvents; D011718:Pyrazinamide; D007538:Isoniazid; D012293:Rifampin