title: Low frequency of human papillomavirus detection in prostate tissue from individuals from Northern Brazil.
abstract: The presence of human papillomavirus (HPV) was evaluated in 65 samples of prostate tumours and six samples of prostates with benign prostatic hyperplasia from individuals from Northern Brazil. We used a highly sensitive test, the Linear Array HPV Genotyping Test, to detect 37 high and low-risk HPV types. In this study, only 3% of tumour samples showed HPV infection. Our findings support the conclusion that, despite the high incidence of HPV infection in the geographic regions studied, HPV was not associated with a higher risk of prostate cancer. To our knowledge, this is the first study evaluating the frequency of HPV detection in prostatic tissue of individuals from Brazil.
authors.affiliation: Departamento de Anatomia Patológica, Hospital Universitário João de Barros Barreto, Instituto de Ciências Biológicas, Universidade Federal do Pará, Campus Universitário do Guamá, 66075-900 Belém, PA, Brasil. .
authors.forename: Rodrigo Vellasco Duarte
authors.initials: RV
authors.lastname: Silvestre
authors.forename: Mariana Ferreira
authors.initials: MF
authors.lastname: Leal
authors.forename: Samia
authors.initials: S
authors.lastname: Demachki
authors.forename: Márcia Cristina de Souza
authors.initials: MC
authors.lastname: Nahum
authors.forename: Julio Guilherme Balieiro
authors.initials: JG
authors.lastname: Bernardes
authors.forename: Silvia Helena Barem
authors.initials: SH
authors.lastname: Rabenhorst
authors.forename: Marília de Arruda Cardoso
authors.initials: Mde A
authors.lastname: Smith
authors.forename: Wyller Alencar de
authors.initials: WA
authors.lastname: Mello
authors.forename: Adriana Costa
authors.initials: AC
authors.lastname: Guimarães
authors.forename: Rommel Rodríguez
authors.initials: RR
authors.lastname: Burbano
mesh_terms: D004279:DNA, Viral / Q000032:analysis; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000175:diagnosis* / Q000821:virology; D016133:Polymerase Chain Reaction; D011470:Prostatic Hyperplasia / Q000821:virology*; D011471:Prostatic Neoplasms / Q000821:virology*
chemical_list: D004279:DNA, Viral