Secoiridoid and iridoid glucosides from the leaves of Fraxinus griffithii.
Phytochemical investigation of the dried leaves of Fraxinus griffithii collected in Okinawa has led to the isolation of three new secoiridoid glucosides, griffithosides A-C (1-3), and one new iridoid glucoside, 7-epi-7-O-(E)-caffeoylloganic acid (4), along with eight known secoiridoid glucosides (5-12). The structures of these compounds were elucidated by means of NMR, MS, and other spectroscopic techniques, as well as comparison with literature data. The isolated compounds were tested for radical-scavenging activity. Among them, compounds 3, 4, and 7 exhibited substantial radical-scavenging activity.
Macahig
Rene Angelo
RA
Department of Pharmacognosy, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, Japan.
Harinantenaina
Liva
L
Matsunami
Katsuyoshi
K
Otsuka
Hideaki
H
Takeda
Yoshio
Y
Shinzato
Takakazu
T
D031661:Fraxinus / Q000737:chemistry*; D016166:Free Radical Scavengers / Q000302:isolation & purification / Q000494:pharmacology; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D039823:Iridoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018515:Plant Leaves; D013057:Spectrum Analysis / Q000379:methods
D016166:Free Radical Scavengers; D005960:Glucosides; D039823:Iridoids