title: LINGO1 rs9652490 is associated with essential tremor and Parkinson disease.
abstract: Recently, a variant in LINGO1 (rs9652490) was found to associate with increased risk of essential tremor. We set out to replicate this association in an independent case-control series of essential tremor from North America. In addition, given the clinical and pathological overlap between essential tremor and Parkinson disease, we also evaluate the effect of LINGO1 rs9652490 in two case-control series of Parkinson disease. Our study demonstrates a significant association between LINGO1 rs9652490 and essential tremor (P = 0.014) and Parkinson disease (P = 0.0003), thus providing the first evidence of a genetic link between both diseases.
authors.affiliation: Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA. VilarinoGuell.Carles@mayo.edu
authors.forename: Carles
authors.initials: C
authors.lastname: Vilariño-Güell
authors.forename: Owen A
authors.initials: OA
authors.lastname: Ross
authors.forename: Christian
authors.initials: C
authors.lastname: Wider
authors.forename: Barbara
authors.initials: B
authors.lastname: Jasinska-Myga
authors.forename: Stephanie A
authors.initials: SA
authors.lastname: Cobb
authors.forename: Alexandra I
authors.initials: AI
authors.lastname: Soto-Ortolaza
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: Kachergus
authors.forename: Brett H
authors.initials: BH
authors.lastname: Keeling
authors.forename: Justus C
authors.initials: JC
authors.lastname: Dachsel
authors.forename: Heather L
authors.initials: HL
authors.lastname: Melrose
authors.forename: Bahareh
authors.initials: B
authors.lastname: Behrouz
authors.forename: Zbigniew K
authors.initials: ZK
authors.lastname: Wszolek
authors.forename: Ryan J
authors.initials: RJ
authors.lastname: Uitti
authors.forename: Jan O
authors.initials: JO
authors.lastname: Aasly
authors.forename: Alex
authors.initials: A
authors.lastname: Rajput
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Farrer
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D020329:Essential Tremor / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D007391:International Cooperation; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000235:genetics*; D010300:Parkinson Disease / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*
chemical_list: C482293:LINGO1 protein, human; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins