title: Cortico-muscular coherence increases with tremor improvement after deep brain stimulation in Parkinson's disease.
abstract: Deep brain stimulation on the subthalamic nucleus has been used to relieve Parkinsonian motor symptoms. However, the underlying physiological mechanism has not been fully understood. Beta-band cortico-muscular coherence increases when healthy humans perform isometric contraction. We hypothesized that this might be a measure of symptomatic improvement in motor performance after subthalamic nucleus deep brain stimulation. Here, we measured the beta-band cortico-muscular coherence with magnetoencephalography from three Parkinson's disease patients. We then compared the coherence values for stimulator on-state and off-state. We found that when the stimulator is on, the beta cortico-muscular coherence elevates significantly for the tremorous hand compared with that when the stimulator is off. This suggests that deep brain stimulation resulted in better cortico-muscular coordination.
authors.affiliation: MEG Center, Seoul National University Hospital, Seoul National University College of Medicine, 101 Daehangno, Jongno-gu, Seoul 110-744, Korea.
authors.forename: Hame
authors.initials: H
authors.lastname: Park
authors.forename: June Sic
authors.initials: JS
authors.lastname: Kim
authors.forename: Sun Ha
authors.initials: SH
authors.lastname: Paek
authors.forename: Beom Seok
authors.initials: BS
authors.lastname: Jeon
authors.forename: Jee Young
authors.initials: JY
authors.lastname: Lee
authors.forename: Chun Kee
authors.initials: CK
authors.lastname: Chung
mesh_terms: D000368:Aged; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000503:physiopathology*; D046690:Deep Brain Stimulation / Q000379:methods*; D004576:Electromyography / Q000379:methods; D006225:Hand / Q000294:innervation; D006801:Humans; D007537:Isometric Contraction / Q000502:physiology; D015225:Magnetoencephalography / Q000379:methods; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000503:physiopathology*; D010300:Parkinson Disease / Q000150:complications* / Q000628:therapy; D020531:Subthalamic Nucleus / Q000502:physiology; D016896:Treatment Outcome; D014202:Tremor / Q000209:etiology / Q000628:therapy*