title: Thigh circumference and risk of heart disease and premature death: prospective cohort study.
abstract: OBJECTIVE
  To examine associations between thigh circumference and incident cardiovascular disease and coronary heart disease and total mortality.
  
  
  METHODS
  Prospective observational cohort study with Cox proportional hazards model and restricted cubic splines.
  
  
  METHODS
  Random subset of adults in Denmark.
  
  
  METHODS
  1436 men and 1380 women participating in the Danish MONICA project, examined in 1987-8 for height, weight, and thigh, hip, and waist circumference, and body composition by impedance.
  
  
  METHODS
  10 year incidence of cardiovascular and coronary heart disease and 12.5 years of follow-up for total death.
  
  
  RESULTS
  A small thigh circumference was associated with an increased risk of cardiovascular and coronary heart diseases and total mortality in both men and women. A threshold effect for thigh circumference was evident, with greatly increased risk of premature death below around 60 cm. Above the threshold there seemed to be no additional benefit of having larger thighs in either sex. These findings were independent of abdominal and general obesity, lifestyle, and cardiovascular risk factors such as blood pressure and lipid concentration.
  
  
  CONCLUSIONS
  A low thigh circumference seems to be associated with an increased risk of developing heart disease or premature death. The adverse effects of small thighs might be related to too little muscle mass in the region. The measure of thigh circumference might be a relevant anthropometric measure to help general practitioners in early identification of individuals at an increased risk of premature morbidity and mortality.
authors.affiliation: Research Unit for Dietary Studies, Institute of Preventive Medicine, Copenhagen University Hospital, DK-1357 Copenhagen K, Denmark. blh@ipm.regionh.dk
authors.forename: Berit L
authors.initials: BL
authors.lastname: Heitmann
authors.forename: Peder
authors.initials: P
authors.lastname: Frederiksen
mesh_terms: D000328:Adult; D000368:Aged; D001823:Body Composition / Q000502:physiology; D001827:Body Height / Q000502:physiology; D001835:Body Weight / Q000502:physiology; D003327:Coronary Disease / Q000401:mortality* / Q000473:pathology; D003718:Denmark / Q000453:epidemiology; D042241:Early Diagnosis; D017097:Electric Impedance; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D013848:Thigh / Q000033:anatomy & histology*