title: Comparative assessment of siRNA and shRNA off target effects: what is slowing clinical development.
abstract: This review considers comparisons of the off-target effects of siRNA to shRNA and their potential impact on the efficacy and toxicity of RNAi based therapeutics.
authors.affiliation: Gradalis Inc., Dallas, TX, USA.
authors.forename: D D
authors.initials: DD
authors.lastname: Rao
authors.forename: N
authors.initials: N
authors.lastname: Senzer
authors.forename: M A
authors.initials: MA
authors.lastname: Cleary
authors.forename: J
authors.initials: J
authors.lastname: Nemunaitis
mesh_terms: D015316:Genetic Therapy; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism; D009369:Neoplasms / Q000628:therapy; D034622:RNA Interference / Q000502:physiology*; D034741:RNA, Small Interfering / Q000235:genetics / Q000378:metabolism*
chemical_list: D035683:MicroRNAs; D034741:RNA, Small Interfering