title: [Intrathecal baclofen therapy.   Overdose during replacement of a medication pump].
abstract: This case report reviews the anesthesiological complications of intrathecal baclofen (ITB) therapy. An 11-year-old boy with spasticity and apallic syndrome needed general anesthesia for exchange of a baclofen pump but 2 h later he became increasingly hypothermic, hypotonic with bradycardy and dyspnea. The cause was an intra-operative bolus of ITB. Reduction of the baclofen administration rate caused disappearance of all symptoms without any residual effects. The ITB is an increasingly used therapeutic option for multiple sclerosis and cerebral palsy. Therefore, emergency personal and anesthesiologists must be aware of the possible side effects of this medication.
authors.affiliation: Klinik für Anästhesiologie und Operative Intensivmedizin, Universitätsklinikum Köln, Köln. kathrin.kramer@uk-koeln.de
authors.forename: K
authors.initials: K
authors.lastname: Kramer
authors.forename: M
authors.initials: M
authors.lastname: Weber
authors.forename: A
authors.initials: A
authors.lastname: Koulousakis
authors.forename: H
authors.initials: H
authors.lastname: Lier
authors.forename: H
authors.initials: H
authors.lastname: Krep
mesh_terms: D000768:Anesthesia, General; D001418:Baclofen / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use*; D002547:Cerebral Palsy / Q000188:drug therapy; D002648:Child; D062787:Drug Overdose; D006801:Humans; D015918:Infusion Pumps, Implantable; D007278:Injections, Spinal; D007431:Intraoperative Complications / Q000139:chemically induced / Q000503:physiopathology; D008297:Male; D009125:Muscle Relaxants, Central / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use*; D009128:Muscle Spasticity / Q000188:drug therapy
chemical_list: D009125:Muscle Relaxants, Central; D001418:Baclofen