title: Significant association between the C(-1019)G functional polymorphism of the HTR1A gene and impulsivity.
abstract: Serotonin-1A (5-HT(1A)) receptors are known to play a role in impulsivity-related behavior. The C(-1019)G functional polymorphism (rs6295) has been suggested to regulate the 5-HT(1A) receptor gene (HTR(1A)) expression in presynaptic raphe neurons, namely, increased receptor concentration and reduced neuronal firing could be associated with the G allele. Previous studies indicate that this polymorphism is associated with aggression, suicide, and several psychiatric disorders, yet its association with impulsivity has rarely been investigated. We studied the relationship between impulsivity and the C(-1019)G polymorphism of the HTR(1A) in a population sample of 725 volunteers using the Impulsiveness subscale (IVE-I) of the Eysenck Impulsiveness, Venturesomeness, and Empathy scale and also the Barratt Impulsiveness Scale (BIS-11). Data were analyzed using analysis of variance with age and gender as covariates and Tukey's HSD post-hoc test. Post-hoc analysis revealed that the study had 0.958 power to detect 0.15 effect size. Significant differences between the C(-1019)G genotype groups (GG vs. GC vs. CC) were found. Subjects carrying GG genotype showed significantly higher impulsiveness scores compared to GC or CC carriers for the IVE-I scale (P = 0.014), for the Motor (P = 0.021), Cognitive Impulsiveness (P = 0.002), and for the BIS total score (P = 0.008) but not for the Nonplanning Impulsiveness (P = 0.520) subscale of the BIS-11. Our results suggest the involvement of the HTR(1A) in the continuum phenotype of impulsivity.
authors.affiliation: Department of Pharmacodynamics, Semmelweis University, Budapest, Hungary.|Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary.
authors.forename: Anita
authors.initials: A
authors.lastname: Benko
authors.affiliation: Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary.
authors.forename: Judit
authors.initials: J
authors.lastname: Lazary
authors.affiliation: Department of Pharmacodynamics, Semmelweis University, Budapest, Hungary.|Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary.
authors.forename: Eszter
authors.initials: E
authors.lastname: Molnar
authors.affiliation: Department of Pharmacodynamics, Semmelweis University, Budapest, Hungary.|Department of Clinical and Theoretical Mental Health, Semmelweis University, Budapest, Hungary.
authors.forename: Xenia
authors.initials: X
authors.lastname: Gonda
authors.affiliation: Department of Pharmacodynamics, Semmelweis University, Budapest, Hungary.
authors.forename: Laszlo
authors.initials: L
authors.lastname: Tothfalusi
authors.affiliation: Department of Pharmacodynamics, Semmelweis University, Budapest, Hungary.
authors.forename: Dorottya
authors.initials: D
authors.lastname: Pap
authors.affiliation: Faculty of Humanities, Department of Psychology, Karoli Gaspar University of the Reformed Church, Budapest, Hungary.
authors.forename: Zsuzsanna
authors.initials: Z
authors.lastname: Mirnics
authors.affiliation: Department of Psychiatry, Saint John's Hospital, Budapest, Hungary.
authors.forename: Tamas
authors.initials: T
authors.lastname: Kurimay
authors.affiliation: Faculty of Medical and Human Sciences, Neuroscience and Psychiatry Unit, School of Community Based Medicine, The University of Manchester, Manchester, UK.
authors.forename: Diana
authors.initials: D
authors.lastname: Chase
authors.affiliation: Faculty of Medical and Human Sciences, Neuroscience and Psychiatry Unit, School of Community Based Medicine, The University of Manchester, Manchester, UK.
authors.forename: Gabriella
authors.initials: G
authors.lastname: Juhasz
authors.affiliation: Faculty of Medical and Human Sciences, Neuroscience and Psychiatry Unit, School of Community Based Medicine, The University of Manchester, Manchester, UK.
authors.forename: Ian M
authors.initials: IM
authors.lastname: Anderson
authors.affiliation: Faculty of Medical and Human Sciences, Neuroscience and Psychiatry Unit, School of Community Based Medicine, The University of Manchester, Manchester, UK.
authors.forename: John F W
authors.initials: JFW
authors.lastname: Deakin
authors.affiliation: Department of Pharmacodynamics, Semmelweis University, Budapest, Hungary.|Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary.|Group of Neurochemistry and Group of Neuropsychopharmacology, Hungarian Academy of Science and Semmelweis University, Budapest, Hungary.
authors.forename: Gyorgy
authors.initials: G
authors.lastname: Bagdy
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000483:Alleles; D003071:Cognition; D005260:Female; D005824:Genetics, Behavioral; D005838:Genotype; D006801:Humans; D007175:Impulsive Behavior / Q000235:genetics*; D008297:Male; D009474:Neurons / Q000378:metabolism; D011110:Polymorphism, Genetic; D044282:Receptor, Serotonin, 5-HT1A / Q000235:genetics*; D012737:Sex Factors
chemical_list: D044282:Receptor, Serotonin, 5-HT1A