Oenanthe javanica extract accelerates ethanol metabolism in ethanol-treated animals.
The effect of water dropwort (Oenanthe javanica DC) extract in eliminating ethanol was evaluated in New Zealand white rabbit and ICR mice. When a hot-water extract of water dropwort extract and ethanol was injected into New Zealand white rabbit, the plasma ethanol level was rapidly reduced, similar to metadoxine treatment. Specifically, the n-butanol fraction of hot-water extract was the strongest in eliminating plasma alcohol in ICR mice. When ethanol was orally ingested, administration of the hot-water extract eliminated up to 44% of the plasma ethanol in mice while the n-butanol fraction eliminated around 70%. Alcohol removal behaved in a dose-dependent manner in response to 50-200 mg/kg of n-butanol fraction. These data show O. javanica extract is effective in overcoming alcohol intoxication by the accelerating ethanol metabolism.
Kim
Jong Yeon
JY
College of Pharmacy, Yeungnam University, Gyongsan 712-749, Korea.
Kim
Ki-Hoon
KH
Lee
Youn Ju
YJ
Lee
Seung Ho
SH
Park
Jong Cheol
JC
Nam
Doo Hyun
DH
D000079:Acetaldehyde / Q000097:blood; D000818:Animals; D000431:Ethanol / Q000008:administration & dosage* / Q000097:blood / Q000378:metabolism*; D051379:Mice; D008813:Mice, Inbred ICR; D031050:Oenanthe / Q000378:metabolism*; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D011817:Rabbits; D013997:Time Factors
D010936:Plant Extracts; D000431:Ethanol; D000079:Acetaldehyde