A ryanodine receptor agonist promotes the consolidation of long-term memory in young chicks.
Young chicks were trained on a weakly reinforced variant of a single-trial discrimination avoidance task which typically fails to consolidate the long-term memory stage. The ryanodine receptor (RyR) agonist 4-chloro-m-cresol (500 microM, i.c.) persistently promoted high retention until at least 24 h post-training when administered between the time of training and 20 min post-training. The consolidation of the long-term memory stage by RyR activation implicates intracellular calcium release in triggering long-term memory.
Baker
Kathryn D
KD
School of Psychology, Psychiatry and Psychological Medicine, Monash University, Clayton, 3800 Victoria, Australia. Kathryn.Baker@med.monash.edu.au
Edwards
Thomas M
TM
Rickard
Nikki S
NS
D000704:Analysis of Variance; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology; D002120:Calcium Channel Agonists / Q000494:pharmacology; D002645:Chickens; D003408:Cresols / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D012153:Retention, Psychology / Q000187:drug effects / Q000502:physiology*; D019837:Ryanodine Receptor Calcium Release Channel / Q000502:physiology*; D013997:Time Factors
D002120:Calcium Channel Agonists; D003408:Cresols; D019837:Ryanodine Receptor Calcium Release Channel; C006984:chlorocresol