[Effects of laparoscopy-assisted distal gastrectomy on C-reactive protein and visceral proteins in patients with gastric cancer].
OBJECTIVE
To observe the effect of laparoscopy-assisted and open distal gastrectomies on the perioperative levels of C-reactive protein (CRP) and visceral proteins in patients with gastric cancer.


METHODS
T Fifty-three patients with gastric cancer were randomized into two groups to receive laparoscopic surgery (n=26) or open surgery (n=27). The CRP levels were measured preoperatively and at 1, 2, 3 and 7 days after the operation. The levels of the visceral proteins including albumin (ALB), prealbumin (PRE), transferrin (TRF) and retinal-binding protein (RbP) were assayed before and at 3 and 7 days after the operation.


RESULTS
Compared with the preoperative levels, the CRP levels in both groups were significantly increased on days 1, 2, and 3 after the operation (P<0.05), with the highest level occurred on day 2 postoperatively. The postoperative CRP levels were significantly lower in the laparoscopic group than in the open surgery group (P<0.01). The levels of ALB, PRE, TRF, and RbP were significantly decreased after operation in both groups (P<0.01) without significant differences between the two groups (P>0.05).


CONCLUSIONS
Compared with open surgeries, laparoscopy-assisted distal gastrectomy for gastric cancer causes minimal surgical trauma and mild inflammatory responses to allow the recovery of the levels of the visceral proteins.
Deng
Hai-jun
HJ
Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
He
Wei
W
Yu
Jiang
J
Zhang
Ce
C
Wang
Ya-nan
YN
Li
Guo-xin
GX
D000328:Adult; D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism*; D005260:Female; D005743:Gastrectomy; D006801:Humans; D007432:Intraoperative Period; D010535:Laparoscopy; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000097:blood / Q000378:metabolism* / Q000601:surgery*; D055815:Young Adult
D002097:C-Reactive Protein