title: [Impact of rotavirus vaccines in developing countries].
abstract: Rotaviruses discovered in 1973 are the most common cause of severe diarrheal disease in infants and young children world-wide. Annually rotavirus infections are estimated to cause the deaths of more than 600,000 children under the age of 5 years with more than 90% of fatalities occurring in developing countries. In 2006 two live oral attenuated rotavirus vaccines were licensed: the monovalent human rotavirus vaccine (RotarixT) and the pentavalent bovine-human, reassortant vaccine (RotaTeqT). Both vaccines demonstrated excellent safety and protective effectiveness in large pre-licensing trials conducted in Europe, the United States and Latin America. Several countries in Latin and Central America have already decided to include rotavirus vaccines into their national immunization program. African and Asiatic countries have postponed their decisions pending the results of further studies.
authors.affiliation: Fédération de biologie clinique, Hôpital d'Instruction des Armées Bégin Saint Mandé Cedex. familledelacour@gmail.com
authors.forename: H
authors.initials: H
authors.lastname: Delacour
mesh_terms: D003906:Developing Countries; D003967:Diarrhea / Q000517:prevention & control / Q000821:virology; D006801:Humans; D012400:Rotavirus Infections / Q000517:prevention & control*; D022243:Rotavirus Vaccines
chemical_list: D022243:Rotavirus Vaccines