Biliary differentiation and bile duct morphogenesis in development and disease.
The biliary tract consists of a network of intrahepatic and extrahepatic ducts that collect and drain the bile produced by hepatocytes to the gut. The bile ducts are lined by cholangiocytes, a specialized epithelial cell type that has a dual origin. Intrahepatic cholangiocytes derive from the liver precursor cells, whereas extrahepatic cholangiocytes are generated directly from the endoderm. In this review we discuss the mechanisms of cholangiocyte differentiation and bile duct morphogenesis, and describe how developing ducts interact with the hepatic artery. We also present an overview of the mechanisms of biliary dysgenesis in humans.
Raynaud
Peggy
P
Université catholique de Louvain, de Duve Institute, Brussels, Belgium.
Carpentier
Rodolphe
R
Antoniou
Aline
A
Lemaigre
Frédéric P
FP
D000818:Animals; D001652:Bile Ducts / Q000196:embryology / Q000254:growth & development / Q000473:pathology; D001659:Biliary Tract / Q000196:embryology / Q000254:growth & development; D001660:Biliary Tract Diseases / Q000235:genetics / Q000473:pathology*; D002454:Cell Differentiation; D018507:Gene Expression Regulation, Developmental; D022781:Hepatocytes / Q000166:cytology; D006801:Humans; D008099:Liver / Q000196:embryology / Q000254:growth & development / Q000473:pathology; D008107:Liver Diseases / Q000235:genetics / Q000473:pathology*; D035683:MicroRNAs / Q000502:physiology; D009024:Morphogenesis; D015398:Signal Transduction
D035683:MicroRNAs