title: The pathobiology of glioma tumors.
abstract: The ongoing characterization of the genetic and epigenetic alterations in the gliomas has already improved the classification of these heterogeneous tumors and enabled the development of rodent models for analysis of the molecular pathways underlying their proliferative and invasive behavior. Effective application of the targeted therapies that are now in development will depend on pathologists' ability to provide accurate information regarding the genetic alterations and the expression of key receptors and ligands in the tumors. Here we review the mechanisms that have been implicated in the pathogenesis of the gliomas and provide examples of the cooperative nature of the pathways involved, which may influence the initial therapeutic response and the potential for development of resistance.
authors.affiliation: Department of Cancer Biology, Lerner Research Institute, The Cleveland Clinic, Cleveland, Ohio 44195, USA. gladsoc@ccf.org
authors.forename: Candece L
authors.initials: CL
authors.lastname: Gladson
authors.forename: Richard A
authors.initials: RA
authors.lastname: Prayson
authors.forename: Wei Michael
authors.initials: WM
authors.lastname: Liu
mesh_terms: D000818:Animals; D049109:Cell Proliferation; D004195:Disease Models, Animal; D044127:Epigenesis, Genetic; D005910:Glioma / Q000235:genetics* / Q000473:pathology* / Q000628:therapy; D006801:Humans; D015398:Signal Transduction / Q000235:genetics