Stereoselective synthesis of highly functionalized structures from lactate-derived halo ketones.
Highly diastereoselective (i-PrO)(2)TiCl(2)-mediated aldol reactions from lactate-derived alpha'-halo alpha-silyloxy ketones and subsequent treatment of the resultant aldols with a wide range of nucleophiles furnishes highly functionalized arrangements useful in natural product syntheses.
Nebot
Joaquim
J
Departament de Química Orgànica, Universitat de Barcelona, Catalonia, Spain.
Romea
Pedro
P
Urpí
Fèlix
F
D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D019344:Lactic Acid / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
D007659:Ketones; D019344:Lactic Acid