The relationship of the Fas 670 A/G gene polymorphism with cardiovascular risk factors in polycystic ovary syndrome (PCOS) patients.
OBJECTIVE
Apoptosis has been shown in cardiac cells under divergent physiological and pathological conditions. Apoptosis plays a key role in the pathogenesis of cardiac diseases. We aimed to evaluate the relation between Fas 670 A/G gene polymorphism in polycystic ovary syndrome (PCOS) patients carrying a potential risk for developing cardiovascular disease (CVD).


METHODS
Ninety-one patients with PCOS and 100 cases of healthy control people were included in this study. PCOS was defined by the Rotterdam PCOS consensus criteria. The evaluation of genotype for Fas 670 A/G gene polymorphism was performed by using PCR-RFLP method.


RESULTS
The evaluation of Fas genotype and gene allele frequency did not show statistically significant difference between patient and control groups. Both in PCOS patients and control groups, there were no statistically significant differences among A/A, A/G, and G/G.


CONCLUSIONS
We found no relation between the cardiovascular risk factors and Fas 670 A/G gene polymorphism in women with PCOS and healthy subjects. Our results in risk factors of CVD can probably be explained by the fact that metabolic parameters and endothelial systems of the patients may not be affected yet in this short period of time.
Cetinkalp
Sevki
S
Department of Endocrinology and Metabolism Disease, Medical School, Ege University, Bornova, Izmir, Turkey.
Erdogan
Mehmet
M
Karadeniz
Muammer
M
Berdeli
Afig
A
Tamsel
Sadik
S
Ozgen
Ahmet Gokhan
AG
Saygili
Fusun
F
Yilmaz
Candeger
C
D019326:17-alpha-Hydroxyprogesterone / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D002097:C-Reactive Protein / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000097:blood / Q000235:genetics* / Q000276:immunology; D016009:Chi-Square Distribution; D002784:Cholesterol / Q000097:blood; D004247:DNA / Q000737:chemistry / Q000235:genetics; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D005838:Genotype; D006801:Humans; D007328:Insulin / Q000097:blood; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000235:genetics* / Q000276:immunology; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D013739:Testosterone / Q000097:blood; D014280:Triglycerides / Q000097:blood; D019014:fas Receptor / Q000235:genetics* / Q000276:immunology
D001786:Blood Glucose; D007328:Insulin; D014280:Triglycerides; D019014:fas Receptor; D013739:Testosterone; D019326:17-alpha-Hydroxyprogesterone; D005340:Fibrinogen; D002097:C-Reactive Protein; D004247:DNA; D002784:Cholesterol