title: Flavanoids and pterocarpans from the bark of Erythrina fusca.
abstract: Three new isomeric flavanones, fuscaflavanones A(1) (1), A(2) (2) and B (3), together with six known flavanones, lupinifolin (4), lonchocarpol A (5), a mixture of lonchocarpols C(1) and C(2) (6a, b), and a mixture of lonchocarpols D(1) and D(2) (7a, b), five pterocarpans, sandwicensin (8), phaseollidin (9), erythrabissin I (10), and a mixture of dolichins A and B (11a, b), one chalcone, isobavachalcone (12), and one isoflavone, wighteone (13), were isolated from the bark of Erythrina fusca LOUR. Their structures were elucidated on the basis of spectroscopic data. Some isolates were tested for antiplasmodial and cytotoxic activities and it was found that 5 and 9 exhibited moderate antiplasmodial activity against Plasmodium falciparum. For cytotoxicity, compounds 1, 4, 5, 9 and 12 showed moderate to weak activity against KB, BC and NCI-H187 cells, whereas 2 exhibited only weak activity against KB cells.
authors.affiliation: Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Ramkhamhaeng University, Thailand.
authors.forename: Phongsak
authors.initials: P
authors.lastname: Innok
authors.forename: Thitima
authors.initials: T
authors.lastname: Rukachaisirikul
authors.forename: Apichart
authors.initials: A
authors.lastname: Suksamrarn
mesh_terms: D000962:Antimalarials / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D004895:Erythrina / Q000737:chemistry*; D047309:Flavones / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity / Q000652:urine; D005419:Flavonoids / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D006801:Humans; D007536:Isomerism; D024301:Plant Bark / Q000737:chemistry; D036343:Pterocarpans / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity
chemical_list: D000962:Antimalarials; D047309:Flavones; D005419:Flavonoids; D036343:Pterocarpans; C545016:fuscaflavanone A1; C545017:fuscaflavanone A2; C545018:fuscaflavanone B