Neuroanatomical correlates of olfactory performance.
We investigated associations between olfactory function and gray matter thickness in 46 healthy young subjects by means of an automated technique for measuring cortical thickness. We used an extended version of the Sniffin' Sticks test to assess olfactory function, including odor threshold, concentration discrimination, quality discrimination, and odor identification. We observed a correlation between olfactory performance and cortical thickness of structures involved in earlier and later stages of chemosensory processing such as right medial orbitofrontal cortex, right insula, and adjacent cortex. Furthermore, we found significant bilateral correlations of olfactory performance with cortical thickness of areas around the central sulcus bilaterally, structures responsible for voluntary respiration and sniffing. In addition to expected general sex effects on cortical thickness, we observed areas, such as the entorhinal cortex, occipital cortex, intraparietal sulcus and insula (all in the right hemisphere), where the correlation between higher order olfactory functions and cortical thickness differed between women and men. These data demonstrate, for some neuroanatomical structures, a link between cortical thickness and olfactory function, in that thicker cortex is usually associated with better performance, but not always. This association between anatomy and olfactory performance suggests a possible biological explanation for the high degree of individual differences and sex effects observed in higher order olfactory tasks.
Frasnelli
Johannes
J
Centre Hospitalier Universitaire Sainte-Justine, Université de Montréal, Montreal, Canada. frasnelli@yahoo.com
Lundström
Johan N
JN
Boyle
Julie A
JA
Djordjevic
Jelena
J
Zatorre
Robert J
RJ
Jones-Gotman
Marilyn
M
D000222:Adaptation, Physiological / Q000502:physiology; D000328:Adult; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000033:anatomy & histology* / Q000502:physiology*; D004192:Discrimination, Psychological / Q000502:physiology; D004292:Dominance, Cerebral / Q000502:physiology; D018728:Entorhinal Cortex / Q000033:anatomy & histology / Q000502:physiology; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests; D009833:Olfactory Pathways / Q000033:anatomy & histology* / Q000502:physiology*; D017397:Prefrontal Cortex / Q000033:anatomy & histology / Q000502:physiology; D011594:Psychometrics; D012684:Sensory Thresholds / Q000502:physiology; D012727:Sex Characteristics; D012903:Smell / Q000502:physiology*; D055815:Young Adult