The emerging role of the RAB25 small GTPase in cancer.
RAB25, a member of the rat sarcoma (RAS) family of small GTPase, has been implicated in the pathophysiology of ovarian, breast and other cancers. Its role in endosomal transport and recycling of cell-surface receptors and signaling proteins presents a novel paradigm for the disruption of cellular pathways and promotion of tumor development and aggressiveness. Variations in structure and post-translational modifications control the localization of RAS superfamily proteins to specific subcellular compartments and recruitment of downstream effectors, allowing these small GTPases to function as sophisticated modulators of a complex and diverse range of cellular processes. Here, we review the link between RAB25 and tumor development and current knowledge regarding its possible roles in cancer.
Agarwal
Roshan
R
Department of Systems Biology, Unit 950, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.
Jurisica
Igor
I
Mills
Gordon B
GB
Cheng
Kwai Wa
KW
D000818:Animals; D005260:Female; D006801:Humans; D008325:Mammary Neoplasms, Experimental / Q000235:genetics* / Q000473:pathology; D008954:Models, Biological; D020559:Monomeric GTP-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D009369:Neoplasms / Q000235:genetics*; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000473:pathology; D051381:Rats; D020691:rab GTP-Binding Proteins / Q000502:physiology*; D018631:ras Proteins / Q000502:physiology*
D020559:Monomeric GTP-Binding Proteins; D020691:rab GTP-Binding Proteins; D018631:ras Proteins