title: C-reactive protein and procalcitonin as predictors of survival and septic shock in ventilator-associated pneumonia.
abstract: We evaluated the performance of procalcitonin (PCT) and C-reactive protein (CRP) threshold values and kinetics as predictors of ventilator-associated pneumonia (VAP) survival and septic shock development. 45 adult patients with VAP were studied. Serum CRP and PCT levels and the Sequential Organ Failure Assessment (SOFA) score were measured on days 1, 4 and 7 (D1, D4, D7) of VAP and their variations between different days (kinetics) were calculated (DeltaPCT, DeltaCRP). A multivariate logistic regression model was constructed with either VAP 28-day survival or septic shock development as dependent variables, and PCT values, CRP values, kinetics, age, sex, SOFA and Acute Physiology and Chronic Health Evaluation (APACHE) II score as independent variables. No difference was found in CRP levels between survivors and nonsurvivors. Nonsurvivors had significantly higher PCT levels on D1 and D7. In the multivariate analysis, the only factors predicting VAP survival were DeltaPCT(7-1) (OR 7.23, 95% CI 0.008-0.468) and DeltaCRP(7-4) (OR 4.59, 95% CI 0.013-0.824). VAP patients who developed septic shock had significantly higher CRP levels on D1 and D7 and higher PCT levels on D1 and D4. The only factor predicting the development of septic shock was SOFA on D1 (OR 7.44, 95% CI 1.330-5.715). Neither PCT and CRP threshold values nor their kinetics can predict VAP survival or septic shock development.
authors.affiliation: Dept of Respiratory and Critical Care Medicine, Sotiria Chest Diseases Hospital, Athens, Greece.
authors.forename: G
authors.initials: G
authors.lastname: Hillas
authors.forename: T
authors.initials: T
authors.lastname: Vassilakopoulos
authors.forename: P
authors.initials: P
authors.lastname: Plantza
authors.forename: A
authors.initials: A
authors.lastname: Rasidakis
authors.forename: P
authors.initials: P
authors.lastname: Bakakos
mesh_terms: D018806:APACHE; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D002116:Calcitonin / Q000097:blood*; D015740:Calcitonin Gene-Related Peptide; D005260:Female; D006801:Humans; D007362:Intensive Care Units / Q000706:statistics & numerical data; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000097:blood / Q000401:mortality; D015999:Multivariate Analysis; D011014:Pneumonia / Q000097:blood / Q000209:etiology / Q000401:mortality; D011237:Predictive Value of Tests; D011498:Protein Precursors / Q000097:blood*; D012121:Respiration, Artificial / Q000009:adverse effects* / Q000401:mortality*; D012772:Shock, Septic / Q000097:blood / Q000209:etiology / Q000401:mortality
chemical_list: D015415:Biomarkers; C000606589:CALCA protein, human; D011498:Protein Precursors; D002116:Calcitonin; D002097:C-Reactive Protein; D015740:Calcitonin Gene-Related Peptide