title: Total synthesis and structural revision of (+/-)-tricholomalides A and B.
abstract: The neurotrophic diterpenoids, tricholomalides A and B, were synthesized in a concise fashion. Key transformations include a ketene [2 + 2] cycloaddition and a Grignard-type reaction. In the course of the synthesis, it was determined that the structures of tricholomalides A and B had originally been misassigned.
authors.affiliation: Department of Chemistry, Columbia University, Havemeyer Hall, 3000 Broadway, New York, New York 10027, USA.
authors.forename: Zhang
authors.initials: Z
authors.lastname: Wang
authors.forename: Sun-Joon
authors.initials: SJ
authors.lastname: Min
authors.forename: Samuel J
authors.initials: SJ
authors.lastname: Danishefsky
mesh_terms: D004224:Diterpenes / Q000138:chemical synthesis* / Q000737:chemistry; D005030:Ethylenes / Q000737:chemistry; D007659:Ketones / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D004224:Diterpenes; D005030:Ethylenes; D007659:Ketones; C482765:tricholomalide A; C482766:tricholomalide B; C008223:ketene