title: Investigation on the effect of immune selection on resistance to bactericidal antibodies to group B meningococci in vitro.
abstract: The induction of resistance by immune selective pressure to bactericidal antibodies from humans immunized with Novartis recombinant meningococcal group B vaccines was assessed. Serum bactericidal antibody titers against selected bacteria were within assay variability through a selection event frequency of 1 in 10(-5). No change in antigen expression was observed by Western blotting.
authors.affiliation: Novartis Vaccines, 350 Mass Ave., Cambridge, MA 02139, USA. george.santos@novartis.com
authors.forename: George F
authors.initials: GF
authors.lastname: Santos
authors.forename: Marzia
authors.initials: M
authors.lastname: Giuliani
authors.forename: Laura
authors.initials: L
authors.lastname: Santini
authors.forename: Jeanette
authors.initials: J
authors.lastname: Adu-Bobie
authors.forename: Mariagrazia
authors.initials: M
authors.lastname: Pizza
authors.forename: Rino
authors.initials: R
authors.lastname: Rappuoli
authors.forename: William
authors.initials: W
authors.lastname: Wacknov
authors.forename: John
authors.initials: J
authors.lastname: Donnelly
mesh_terms: D000907:Antibodies, Bacterial / Q000097:blood / Q000276:immunology*; D001770:Blood Bactericidal Activity; D006801:Humans; D022401:Meningococcal Vaccines / Q000276:immunology*; D050296:Microbial Viability; D038541:Neisseria meningitidis, Serogroup B / Q000276:immunology*; D012641:Selection, Genetic
chemical_list: D000907:Antibodies, Bacterial; D022401:Meningococcal Vaccines