Gamma-lactones and ent-eudesmane sesquiterpenes from the endophytic fungus Eutypella sp. BCC 13199.
Two new gamma-lactones, eutypellins A (1) and B (2), and two ent-eudesmane sesquiterpenes, ent-4(15)-eudesmen-11-ol-1-one (3) and ent-4(15)-eudesmen-1alpha,11-diol (4), together with three known pimarane diterpenes, diaporthein B, scopararane A, and libertellenone C, were isolated from the endophytic fungus Eutypella sp. BCC 13199. The structures of these compounds were elucidated by interpretation of spectroscopic data. The absolute configuration of 4 was confirmed by application of the modified Mosher's method. Eutypellin A (1) and sesquiterpene 3 exhibited weak cytotoxic activities.
Isaka
Masahiko
M
National Center for Genetic Engineering and Biotechnology, 113 Thailand Science Park, Phaholyothin Road, Klong Luang, Pathumthani 12120, Thailand.
Palasarn
Somporn
S
Lapanun
Sanisa
S
Chanthaket
Rungtiwa
R
Boonyuen
Nattawut
N
Lumyong
Saisamorn
S
D000818:Animals; D002176:Candida albicans / Q000187:drug effects; D002522:Chlorocebus aethiops; D004224:Diterpenes / Q000302:isolation & purification; D004354:Drug Screening Assays, Antitumor; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D020082:Magnaporthe / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D010963:Plasmodium falciparum / Q000187:drug effects; D045787:Sesquiterpenes, Eudesmane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013237:Stereoisomerism; D013785:Thailand; D014709:Vero Cells; D013098:Xylariales / Q000737:chemistry*
D004224:Diterpenes; D005663:Furans; D045787:Sesquiterpenes, Eudesmane; C478319:diaporthein B; C544228:ent-4(15)-eudesmen-11-ol-1-one; C544227:ent-4(15)-eudesmen-1alpha,11-diol; C544225:eutypellin A; C544226:eutypellin B