A predictor of positive drug provocation testing in individuals with saddle-back type ST-segment elevation.
BACKGROUND
A drug provocation test is performed to unmask a type 1 electrocardiogram (ECG) in individuals with saddle-back type ST-segment elevation in the right precordial leads (SB-ECG). The study investigated predictors of positive responders (PR) by drug testing.


RESULTS
A total of 58 consecutive individuals with SB-ECG in lead V2 were enrolled and drug testing was performed. In leads V2 at standard and the third intercostal space (V2(IC3)), the QRS duration was measured, the amplitudes of r' wave (r'), ST-segment 20 and 40 ms after the r' wave (r'20 and r'40, respectively), the bottom of the ST-segment (ST(b)), the differences between r' and r'20 (r'-r'20), r' and r'40 (r'-r'40), r' and ST(b) (r'-ST(b)), and the descending rate of the ST-segment [(r'-r'20)/r'; DR20, (r'-r'20)/(r'-ST(b)); DR20-ST(b)] were also measured. Thirty-five PR had significantly longer QRS duration, larger r'20 and r'40, and smaller r'-r'20, DR20, and DR20-ST(b) than negative responders. DR20 and DR20-ST(b) in leads V2 and V2(IC3) were most significantly different between 2 groups. The positive and negative predictive values of ;DR20-ST(b) in lead V2(IC3) <0.62' for prediction of positive tests were 92.3% and 81.8%, respectively.


CONCLUSIONS
In individuals with SB-ECG, DR20 and DR20-ST(b) in leads V2 and V2(IC3) might be useful predictors of positive testing.
Shimeno
Kenji
K
Department of Internal Medicine and Cardiology, Osaka City University Graduate School of Medicine, Japan.
Takagi
Masahiko
M
Maeda
Keiko
K
Tatsumi
Hiroaki
H
Doi
Atsushi
A
Nakagawa
Eiichiro
E
Yoshiyama
Minoru
M
D000200:Action Potentials; D000328:Adult; D053840:Brugada Syndrome / Q000175:diagnosis* / Q000503:physiopathology; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008012:Lidocaine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012372:ROC Curve; D012680:Sensitivity and Specificity; D026941:Sodium Channel Blockers / Q000008:administration & dosage; D013997:Time Factors
D026941:Sodium Channel Blockers; D008012:Lidocaine; C042288:pilsicainide