title: Object memory in young and aged mice after sevoflurane anaesthesia.
abstract: Learning and memory are cognitive functions commonly impaired after surgery, especially in elderly patients. Our aim was to evaluate the effect of sevoflurane anaesthesia on episodic-like memory in young and aged wild-type mice and mice with altered nicotinic cholinergic neurotransmission (beta2KO). Mice learned objects before randomization to control, anaesthesia or sham groups. Anaesthesia was maintained at 2.6% sevoflurane for 2 h, starting immediately after training. Object memory testing was performed after 24 h, when one familiar object was replaced by a nonfamiliar object. While nonanaesthetized mice showed memory retention of the familiar object, anaesthetized wild-type and beta2KO mice showed impaired memory. Sevoflurane anaesthesia thus causes memory impairment in mice regardless of beta2 receptor-mediated nicotinic cholinergic neurotransmission.
authors.affiliation: Department of Anaesthesiology, Surgical Services and Intensive Care Medicine, Karolinska University Hospital, Stockholm, Sweden. andreas.wiklund@karolinska.se
authors.forename: Andreas
authors.initials: A
authors.lastname: Wiklund
authors.forename: Sylvie
authors.initials: S
authors.lastname: Granon
authors.forename: Philippe
authors.initials: P
authors.lastname: Faure
authors.forename: Eva
authors.initials: E
authors.lastname: Sundman
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Changeux
authors.forename: Lars I
authors.initials: LI
authors.lastname: Eriksson
mesh_terms: D000375:Aging; D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D000818:Animals; D004193:Discrimination Learning / Q000187:drug effects; D005106:Exploratory Behavior / Q000187:drug effects; D005260:Female; D008297:Male; D008568:Memory / Q000187:drug effects*; D008738:Methyl Ethers / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D011897:Random Allocation; D011978:Receptors, Nicotinic / Q000172:deficiency; D000077149:Sevoflurane; D013997:Time Factors
chemical_list: D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D011978:Receptors, Nicotinic; D000077149:Sevoflurane