TCF7L2 polymorphism associates with new-onset diabetes after transplantation.
New-onset diabetes after transplantation (NODAT) is a serious and frequent complication in transplant recipients. Whether NODAT shares the same susceptibility genes as type 2 diabetes is unknown. In this multicenter study, we genotyped 1076 white patients without diabetes at transplantation for 11 polymorphisms that associate with type 2 diabetes. We defined NODAT as a fasting plasma glucose > or =126 mg/dl on at least two occasions or de novo hypoglycemic therapy. We compared clinical and genetic factors between patients who developed NODAT within 6 mo of transplantation (n = 118; incidence 11%) and patients without diabetes (n = 958). In multivariate analysis, NODAT significantly associated with the following characteristics: TCF7L2 polymorphism (odds ratio [OR] 1.60 per each T allele; P = 0.002), age (OR 1.03 per year; P < 0.001), body mass index at transplantation (OR 1.09 per unit; P < 0.001), tacrolimus use (OR 2.26; P < 0.001), and the occurrence of a corticoid-treated acute rejection episode (OR 2.78; P < 0.001). In summary, our data show that the TCF7L2 rs7903146 polymorphism, a known risk factor for type 2 diabetes in the general population, also associates with NODAT.
Ghisdal
Lidia
L
Clinique de Transplantation Rénale, Hôpital Erasme-ULB, 1070 Bruxelles, Belgique. lghisdal@yahoo.com
Baron
Christophe
C
Le Meur
Yannick
Y
Lionet
Arnaud
A
Halimi
Jean-Michel
JM
Rerolle
Jean-Philippe
JP
Glowacki
François
F
Lebranchu
Yvon
Y
Drouet
Mireille
M
Noël
Christian
C
El Housni
Hakim
H
Cochaux
Pascale
P
Wissing
Karl Martin
KM
Abramowicz
Daniel
D
Abramowicz
Marc
M
D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005260:Female; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011183:Postoperative Complications / Q000209:etiology*; D051820:TCF Transcription Factors / Q000235:genetics*; D058118:Transcription Factor 7-Like 2 Protein
D051820:TCF Transcription Factors; C544894:TCF7L2 protein, human; D058118:Transcription Factor 7-Like 2 Protein