title: [Laparoscopic versus open resection for colorectal cancer: meta-analysis of the chief trials].
abstract: BACKGROUND
  The objective of this study is in the critical analysis of the results of the lap and open surgery in the colorectal carcinoma, through the meta-analysis of the principal trials.
  
  
  METHODS
  A systematic search of the comparative studies has been made among lap and open surgery in the colorectal carcinoma, using PubMed and Cochrane Library. Among these, have been selected perspective studies containing the description of the surgical techniques, the perioperative results and the oncological long term results. Statistic analysis has been performed with the program NCSS (Kaysville 2006, Utah).
  
  
  RESULTS
  From the revision of the literature, 7 perspective studies have checked fit to a meta-analysis, for a total of 3580 patients. Among the operative outcomes, has been observed, with statistically significant, a reduction of the blood loss and of the morbidity, an earlier resumption to passing flatus and to normal diet, a reduction of the postoperative hospitalization for the lap; shorter operative time is releaved for the open surgery. Statistically significant differences have emerged neither on the other surgical outcomes (included mortality) nor on relapset of illness (regional or metastasis), crab-correlated mortality, long term survival.
  
  
  CONCLUSIONS
  The laparoscopic can be considered a valid alternative to the traditional open surgery in the therapy of the colorectal carcinoma: the advantages consist in smaller trauma and reduction of morbidity and postoperative stay. The oncological results are the same of the open surgery.
authors.affiliation: Ospedale Le Scotte, Siena, Italia, Dipartimento di Chirurgia Generale.
authors.forename: F
authors.initials: F
authors.lastname: Coratti
authors.forename: A
authors.initials: A
authors.lastname: Coratti
authors.forename: R
authors.initials: R
authors.lastname: Malatesti
authors.forename: W
authors.initials: W
authors.lastname: Testi
authors.forename: F
authors.initials: F
authors.lastname: Tani
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000601:surgery*; D000368:Aged; D000369:Aged, 80 and over; D016063:Blood Loss, Surgical; D003082:Colectomy / Q000379:methods; D015179:Colorectal Neoplasms / Q000401:mortality / Q000601:surgery*; D013505:Digestive System Surgical Procedures / Q000379:methods; D019317:Evidence-Based Medicine; D005260:Female; D006801:Humans; D010535:Laparoscopy / Q000379:methods*; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D016032:Randomized Controlled Trials as Topic; D016896:Treatment Outcome