title: Charcot neuroarthropathy of the foot and ankle.
abstract: Charcot neuroarthropathy is a common cause of morbidity in persons with diabetes mellitus and sensory neuropathy. Although Charcot neuroarthropathy is rare, it likely will become more prevalent in conjunction with increased incidence of diabetes mellitus. Prevention of disease progression remains the mainstay of treatment, with surgical intervention usually reserved for refractory cases. Late deformities are often complicated by chronic ulceration, infection, and osteomyelitis. The clinical presentation is best summarized with the Eichenholtz classification, and progression often follows a predictable pattern. Although Charcot neuroarthropathy is a clinical diagnosis, recent advances in diagnostic imaging have eased the clinical challenge of deciphering infection from Charcot changes. Advances in surgical treatment have demonstrated new options for limb salvage. Pharmacologic therapies directed toward decreasing bone resorption have also shown promise for treatment, but clinical application remains theoretical.
authors.affiliation: Jackson Memorial Hospital/University of Miami Orthopaedic Residency Program, Miami, FL, USA.
authors.forename: Alexander
authors.initials: A
authors.lastname: van der Ven
authors.forename: Cary B
authors.initials: CB
authors.lastname: Chapman
authors.forename: John H
authors.initials: JH
authors.lastname: Bowker
mesh_terms: D000843:Ankle Joint / Q000000981:diagnostic imaging; D001177:Arthropathy, Neurogenic / Q000000981:diagnostic imaging / Q000209:etiology / Q000628:therapy; D002370:Casts, Surgical; D048909:Diabetes Complications / Q000150:complications; D033023:Foot Joints / Q000000981:diagnostic imaging; D006801:Humans; D023821:Limb Salvage; D011859:Radiography; D016474:Weight-Bearing