Systems biology of stem cell fate and cellular reprogramming.
Stem cell differentiation and the maintenance of self-renewal are intrinsically complex processes requiring the coordinated dynamic expression of hundreds of genes and proteins in precise response to external signalling cues. Numerous recent reports have used both experimental and computational techniques to dissect this complexity. These reports suggest that the control of cell fate has both deterministic and stochastic elements: complex underlying regulatory networks define stable molecular 'attractor' states towards which individual cells are drawn over time, whereas stochastic fluctuations in gene and protein expression levels drive transitions between coexisting attractors, ensuring robustness at the population level.
Macarthur
Ben D
BD
Department of Gene and Cell Medicine and Black Family Stem Cell Institute, Mount Sinai School of Medicine, New York, New York 10029, USA. ben.macarthur@mssm.edu
Ma'ayan
Avi
A
Lemischka
Ihor R
IR
D000818:Animals; D002454:Cell Differentiation / Q000235:genetics / Q000502:physiology; D065150:Cellular Reprogramming; D019295:Computational Biology; D018507:Gene Expression Regulation, Developmental; D053263:Gene Regulatory Networks / Q000235:genetics / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D013234:Stem Cells / Q000166:cytology / Q000502:physiology*; D013269:Stochastic Processes; D049490:Systems Biology