title: Inhibitory effects of guarana seed extract on passive cutaneous anaphylaxis and mast cell degranulation.
abstract: This study investigated the effects of guarana seed extract (GSE) on an anti-allergic mechanism. GSE orally administered inhibited the anti-dinitrophenol IgE-induced passive cutaneous anaphylaxis reaction in mice. Furthermore, it inhibited the degranulation of rat basophilic leukemia RBL-2H3 cells. It had no cytotoxicity on RBL-2H3 cells. These results show that GSE is a candidate for effective therapeutic material for allergic diseases.
authors.affiliation: Department of Food and Nutrition, Faculty of Human Life Sciences, Senri Kinran University, 5-25-1 Fujishirodai, Suita, Osaka 565-0873, Japan. k-jippou@cs.kinran.ac.jp
authors.forename: Tomoko
authors.initials: T
authors.lastname: Jippo
authors.forename: Yuko
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: Harumi
authors.initials: H
authors.lastname: Sato
authors.forename: Atsushi
authors.initials: A
authors.lastname: Hattori
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Takeuchi
authors.forename: Keiichiro
authors.initials: K
authors.lastname: Sugimoto
authors.forename: Munekazu
authors.initials: M
authors.lastname: Shigekawa
mesh_terms: D000818:Animals; D015550:Cell Degranulation / Q000187:drug effects*; D045744:Cell Line, Tumor; D002851:Chromatography, High Pressure Liquid; D008407:Mast Cells / Q000166:cytology / Q000187:drug effects*; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects*; D032126:Paullinia / Q000196:embryology*; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D012639:Seeds / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet
chemical_list: D010936:Plant Extracts