Nonenzymatic electrochemical detection of glucose based on palladium-single-walled carbon nanotube hybrid nanostructures.
A new electrocatalyst, palladium nanoparticle-single-walled carbon nanotube (Pd-SWNTs) hybrid nanostructure, for the nonenzymatic oxidation of glucose was developed and characterized by X-ray diffraction (XRD) and the transmission electron microscope (TEM). The hybrid nanostructures were prepared by depositing palladium nanoparticles with average diameters of 4-5 nm on the surface of single-walled carbon nanotubes (SWNTs) via chemical reduction of the precursor (Pd(2+)). The electrocatalyst showed good electrocatalytic activity toward the oxidation of glucose in the neutral phosphate buffer solution (PBS, pH 7.4) even in the presence of a high concentration of chloride ions. A nonenzymatic amperometric glucose sensor was developed with the use of the Pd-SWNT nanostructure as an electrocatalyst. The sensor had good electrocatalytic activity toward oxidation of glucose and exhibited a rapid response (ca.3 s), a low detection limit (0.2 +/- 0.05 microM), a wide and useful linear range (0.5-17 mM), and high sensitivity (approximately 160 microA mM(-1) cm(-2)) as well as good stability and repeatability. In addition, the common interfering species, such as ascorbic acid, uric acid, 4-acetamidophenol, 3,4-dihydroxyphenylacetic acid, and so forth did not cause any interference due to the use of a low detection potential (-0.35 V vs SCE). The sensor can also be used for quantification of the concentration of glucose in real clinical samples. Therefore, this work has demonstrated a simple and effective sensing platform for nonenzymatic detection of glucose.
Meng
Ling
L
Jiangsu Key Laboratory of Biofunctional Materials, College of Chemistry and Environmental Science, Nanjing Normal University, Nanjing 210097, PR China.
Jin
Juan
J
Yang
Gaixiu
G
Lu
Tianhong
T
Zhang
Hui
H
Cai
Chenxin
C
D015374:Biosensing Techniques / Q000191:economics / Q000379:methods*; D002384:Catalysis; D004563:Electrochemistry / Q000191:economics / Q000379:methods*; D005947:Glucose / Q000032:analysis* / Q000378:metabolism; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D037742:Nanotubes, Carbon / Q000737:chemistry* / Q000648:ultrastructure; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry*; D012680:Sensitivity and Specificity; D013997:Time Factors; D014961:X-Ray Diffraction
D037742:Nanotubes, Carbon; D010165:Palladium; D005947:Glucose