Terretonins E and F, inhibitors of the mitochondrial respiratory chain from the marine-derived fungus Aspergillus insuetus (#).
Two new meroterpenoids, terretonins E and F (1, 2), together with three known compounds, aurantiamine (3), linoleic acid, and uridine, were isolated as fermentation products of the marine-derived fungus Aspergillus insuetus, which was associated with the sponge Petrosia ficiformis. Structures of all isolates were elucidated employing spectroscopic methods, mainly by two-dimensional NMR techniques. Compounds 1-3 showed activity as inhibitors of the mammalian mitochondrial respiratory chain.
López-Gresa
M Pilar
MP
Instituto de Biologia Molecular y Celular de Plantas, Ciudad Politecnica de la Innovacion, 46022 Valencia, Spain. mplopez@ceqa.upv.es
Cabedo
Nuria
N
González-Mas
M Carmen
MC
Ciavatta
Maria Letizia
ML
Avila
Conxita
C
Primo
Jaime
J
D000818:Animals; D001230:Aspergillus / Q000737:chemistry*; D006801:Humans; D008386:Marine Biology; D008928:Mitochondria / Q000187:drug effects* / Q000201:enzymology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D013729:Terpenes; C543992:terretonin E; C543993:terretonin F