title: [Malignant lymphoma presented as left trigeminal neuralgia].
abstract: A male, 60 years of age, presented with transient left facial pain located within all three divisions of the trigeminal nerve. Magnetic resonance imaging (MRI) revealed a swollen left trigeminal nerve with gadolinium enhancement. Following schwannoma diagnosis, the patient received Gamma Knife radiosurgery, which proved effective against symptoms of neuralgia and enhanced lesions. A relapse of unsteadiness was noted 11 months after initial treatment. Furthermore, while MRI presented a normal trigeminal nerve, multiple enhanced white matter mass lesions around the lateral ventricles were observed. Lastly, pathological examinations revealed diffuse large B cell lymphomas. The administration of high-dose methotrexate followed with whole brain radiation therapy appeared to have remarkable effects. No recurrences were observed in a 30 month duration following secondary treatment. Malignant lymphoma may present as trigeminal neuralgia. The conclusions from our case report and another literature review follow a difficult to near impossible task of establishing a correct diagnosis without biopsy in the initial stages of trigeminal nerve tumors. Therefore, a careful MRI follow-up is necessary even if the tumors show a favorable response towards primary steroid treatment or Gamma Knife radiosurgery.
authors.affiliation: Department of Neurology and Neurological Science, Graduate School, Tokyo Medical and Dental University.
authors.forename: Miho
authors.initials: M
authors.lastname: Akaza
authors.forename: Taiji
authors.initials: T
authors.lastname: Tsunemi
authors.forename: Nobuo
authors.initials: N
authors.lastname: Sanjo
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Wakimoto
authors.forename: Daisuke
authors.initials: D
authors.lastname: Kobayashi
authors.forename: Hidehiro
authors.initials: H
authors.lastname: Mizusawa
mesh_terms: D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000150:complications* / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D014277:Trigeminal Neuralgia / Q000209:etiology*