title: Simultaneous magnetically directed drug convection and MR imaging.
abstract: Superparamagnetic iron oxide nanoparticles (IO NPs) are of interest for their usefulness in biomedical applications. In this work, we have synthesized iron oxide nanocomposites surface-modified with different biocompatible polymers. Bovine serum albumin (BSA) was physisorbed onto these IO NPs along with an excipient during freeze-drying. The mass transport of the protein attached to the iron oxide core-shell nanoparticles (IO cs-NPs) under a gradient magnetic field of an MRI instrument was observed in vitro and in an egg as a model system for a biological fluid. From the in vitro experiments in agarose gels, it was observed that the protein gets separated from the core during mass transport for some cs-IO, but co-migration was observed for PEG-modified IO cs-NPs. These experiments demonstrated proof-of-concept for the use of IO cs-NPs in magnetically directed drug convection.
authors.affiliation: Department of Chemistry, University of Manitoba, Winnipeg, MB R3T2N2, Canada.
authors.forename: V
authors.initials: V
authors.lastname: Yathindranath
authors.forename: T
authors.initials: T
authors.lastname: Hegmann
authors.forename: J
authors.initials: J
authors.lastname: van Lierop
authors.forename: K
authors.initials: K
authors.lastname: Potter
authors.forename: C B
authors.initials: CB
authors.lastname: Fowler
authors.forename: D F
authors.initials: DF
authors.lastname: Moore
mesh_terms: D000818:Animals; D002417:Cattle; D005290:Ferric Compounds / Q000737:chemistry*; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D008962:Models, Theoretical; D053761:Nanocomposites / Q000737:chemistry* / Q000648:ultrastructure; D011108:Polymers / Q000737:chemistry*; D012710:Serum Albumin, Bovine / Q000737:chemistry
chemical_list: D005290:Ferric Compounds; D011108:Polymers; C000499:ferric oxide; D012710:Serum Albumin, Bovine