title: Concomitant Aspergillus and Cytomegalovirus infection in heart transplant: early diagnosis is the key to successful treatment.
abstract: Concomitant infections, which are common in patients who have received an organ transplant, must be diagnosed and treated early to prevent high mortality rates. We describe a case of concomitant Cytomegalovirus infection and Aspergillus pneumonia in a heart transplant patient who received pulsed steroids as therapy for rejection, and we describe the successful treatment of that coinfection with ganciclovir and voriconazole.
authors.affiliation: Marmara University Medical School, Infectious Disease and Clinical Microbiology Department, Istanbul, Turkey.
authors.forename: Elif
authors.initials: E
authors.lastname: Tigen
authors.forename: Kursat
authors.initials: K
authors.lastname: Tigen
authors.forename: Tansu
authors.initials: T
authors.lastname: Karaahmet
authors.forename: Zekaver
authors.initials: Z
authors.lastname: Odabasi
authors.forename: Volkan
authors.initials: V
authors.lastname: Korten
mesh_terms: D000208:Acute Disease; D000935:Antifungal Agents / Q000627:therapeutic use*; D000998:Antiviral Agents / Q000627:therapeutic use*; D002311:Cardiomyopathy, Dilated / Q000601:surgery; D003586:Cytomegalovirus Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000821:virology; D042241:Early Diagnosis; D015774:Ganciclovir / Q000627:therapeutic use; D006084:Graft Rejection / Q000188:drug therapy* / Q000276:immunology; D016027:Heart Transplantation / Q000009:adverse effects*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects*; D055744:Invasive Pulmonary Aspergillosis / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D009894:Opportunistic Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology / Q000821:virology; D020551:Pulse Therapy, Drug; D011743:Pyrimidines / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014230:Triazoles / Q000627:therapeutic use; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D000998:Antiviral Agents; D007166:Immunosuppressive Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole; D015774:Ganciclovir