Antibodies induced by dengue virus type 1 and 2 envelope domain III recombinant proteins in monkeys neutralize strains with different genotypes.
In the present work, we evaluated the neutralizing capacity of the antibodies induced by dengue virus type 1 and 2 envelope domain III recombinant proteins in monkeys against strains of different dengue virus type 1 and 2 genotypes. Here we demonstrated that dengue virus type 1 and 2 recombinant proteins induced high titers of neutralizing antibodies against different genotype strains.
Bernardo
Lidice
L
Department of Virology, PAHO/WHO Collaborating Center for the Study of Dengue and Its Vector, Pedro Kourí Tropical Medicine Institute, Autopista Novia del Mediodía, km 6 1/2, P.O. Box 601, Marianao 13, Havana, Cuba.
Fleitas
Osmel
O
Pavón
Alequis
A
Hermida
Lisset
L
Guillén
Gerardo
G
Guzman
Maria G
MG
D000818:Animals; D057134:Antibodies, Neutralizing / Q000097:blood; D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology*; D003429:Cross Reactions; D003715:Dengue / Q000276:immunology* / Q000821:virology; D053059:Dengue Vaccines / Q000276:immunology*; D003716:Dengue Virus / Q000235:genetics / Q000276:immunology*; D005838:Genotype; D008252:Macaca fascicularis; D009500:Neutralization Tests; D011994:Recombinant Proteins / Q000276:immunology* / Q000378:metabolism; D014759:Viral Envelope Proteins / Q000276:immunology* / Q000378:metabolism
D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral; D053059:Dengue Vaccines; D011994:Recombinant Proteins; D014759:Viral Envelope Proteins