title: Zn(II)-Catalyzed synthesis of piperidines from propargyl amines and cyclopropanes.
abstract: The reaction of benzyl-protected propargyl amines and 1,1-cyclopropane diesters in the presence of catalytic Zn(NTf(2))(2) allows access to highly functionalized piperidines in excellent yields. The process proceeds via a tandem cyclopropane ring-opening/Conia-ene cyclization.
authors.affiliation: Department of Chemistry, The University of Western Ontario, London, Ontario, Canada N6A 5B7.
authors.forename: Terry P
authors.initials: TP
authors.lastname: Lebold
authors.forename: Andrew B
authors.initials: AB
authors.lastname: Leduc
authors.forename: Michael A
authors.initials: MA
authors.lastname: Kerr
mesh_terms: D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D003521:Cyclopropanes / Q000737:chemistry*; D015394:Molecular Structure; D010293:Pargyline / Q000031:analogs & derivatives* / Q000737:chemistry; D010880:Piperidines / Q000138:chemical synthesis* / Q000737:chemistry; D011437:Propylamines / Q000737:chemistry*; D015032:Zinc / Q000737:chemistry*
chemical_list: D003521:Cyclopropanes; D010880:Piperidines; D011437:Propylamines; C009054:propargylamine; D010293:Pargyline; D015032:Zinc