title: Asian ethnicity is associated with decreased pregnancy rates following intrauterine insemination.
abstract: Asian ethnicity has been associated with decreased pregnancy outcomes in patients undergoing IVF. The objective of this study was to determine if a difference exists in pregnancy rates between Asian and Caucasian patients undergoing intrauterine insemination (IUI). A retrospective cohort of Asian and Caucasian patients treated with IUI between December 2002 and 2006 was analysed, including 2327 IUI cycles among 814 patients. Baseline characteristics were similar between Asian and Caucasian women. A significantly greater proportion of Asians (43.9%) presented for treatment after more than 2 years of infertility compared with Caucasians (24.6%) (P < 0.0001). Unadjusted analysis showed a trend towards decreased pregnancy rates associated with Asian ethnicity (odds ratio (OR) 0.71, 95% CI 0.50-1.01, not significant). Age, stimulation protocol, differences in gravity and parity, and duration of infertility did not account for this difference (adjusted OR 0.68, 95% CI 0.47-0.98, P = 0.039). Asian ethnicity is associated with lower pregnancy rates in IUI treatment. The increased duration of infertility in Asians does not explain the reduced pregnancy rates.
authors.affiliation: Department of Obstetrics, Gynecology and Reproductive Sciences, University of California at San Francisco, San Francisco, CA, USA.
authors.forename: Julie D
authors.initials: JD
authors.lastname: Lamb
authors.forename: Heather G
authors.initials: HG
authors.lastname: Huddleston
authors.forename: Karen J
authors.initials: KJ
authors.lastname: Purcell
authors.forename: Aisha
authors.initials: A
authors.lastname: Modan
authors.forename: Taraneh T
authors.initials: TT
authors.lastname: Farsani
authors.forename: Margaret A
authors.initials: MA
authors.lastname: Dingeldein
authors.forename: Eric
authors.initials: E
authors.lastname: Vittinghoff
authors.forename: Victor Y
authors.initials: VY
authors.lastname: Fujimoto
mesh_terms: D001208:Asia / Q000208:ethnology; D015331:Cohort Studies; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies