Drug loaded poly[Lac(Glc-Leu)] microparticles: formulation and release characteristics.
Valdecoxib has been entrapped in sub-5 microm particles of poly[Lac(Glc-Leu)] copolymer using a oil-in-water (o/w) emulsification-solvent evaporation technique. To achieve monodispersed sized particles, a microfluidizer was used as ultrasonication device. Formulation parameters such as effect of polymer load, ultrasonication time, stabilizer concentration and stirring rate have a profound effect on particle size, and polydispersity. By adjustment of these parameters, microparticles ranging from about 0.8 to more than 4 microm have been prepared.
Agnihotri
Sagar M
SM
Pharmaceutical Division, Institute of Chemical Technology, University of Mumbai, Nathalal Parikh Street, Matunga, Mumbai 400019, India. agnihotrisagar@hotmail.com
Vavia
Pradeep R
PR
D002626:Chemistry, Pharmaceutical; D004339:Drug Compounding; D016503:Drug Delivery Systems; D007555:Isoxazoles / Q000494:pharmacology*; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D011091:Polyesters / Q000737:chemistry*; D013449:Sulfonamides / Q000494:pharmacology*; D013997:Time Factors; D014465:Ultrasonics; D000096926:Benzenesulfonamides
D007555:Isoxazoles; D011091:Polyesters; D013449:Sulfonamides; C406224:valdecoxib; D000096926:Benzenesulfonamides