title: Granulomatous interstitial nephritis due to tuberculosis-a rare presentation.
abstract: Granulomatous interstitial nephritis (GIN) is an uncommon form of acute interstitial nephritis. We report a young male who presented to us with a rapidly progressing renal failure and massive proteinuria. A renal biopsy revealed GIN, and we were able to demonstrate the presence of tuberculous DNA in the biopsy specimen. The patient was started on anti-tuberculous therapy and steroids besides 11 sessions of hemodialysis. He recovered and is currently doing well. This case highlights an uncommon manifestation of renal tuberculosis, namely massive proteinuria, acute renal failure, and granulomatous interstitial lesions.
authors.affiliation: Department of Nephrology, Meenakshi Mission Hospital and Research Centre, Lake Area, Melur Road, Madurai, Tamil Nadu, India. drksampath@gmail.com
authors.forename: Krishnaswamy
authors.initials: K
authors.lastname: Sampathkumar
authors.forename: Yesudas S
authors.initials: YS
authors.lastname: Sooraj
authors.forename: Amol R
authors.initials: AR
authors.lastname: Mahaldar
authors.forename: Muthiah
authors.initials: M
authors.lastname: Ramakrishnan
authors.forename: Ajeshkumar
authors.initials: A
authors.lastname: Rajappannair
authors.forename: Seethalekshmy V
authors.initials: SV
authors.lastname: Nalumakkal
authors.forename: Elango
authors.initials: E
authors.lastname: Erode
mesh_terms: D000293:Adolescent; D000995:Antitubercular Agents / Q000627:therapeutic use; D001706:Biopsy; D003131:Combined Modality Therapy; D004269:DNA, Bacterial / Q000302:isolation & purification; D004359:Drug Therapy, Combination; D006099:Granuloma / Q000382:microbiology* / Q000473:pathology / Q000628:therapy; D006801:Humans; D008297:Male; D009169:Mycobacterium tuberculosis / Q000235:genetics / Q000302:isolation & purification*; D009395:Nephritis, Interstitial / Q000382:microbiology* / Q000473:pathology / Q000628:therapy; D011507:Proteinuria / Q000382:microbiology; D006435:Renal Dialysis; D051437:Renal Insufficiency / Q000382:microbiology; D013256:Steroids / Q000627:therapeutic use; D013997:Time Factors; D016896:Treatment Outcome; D014398:Tuberculosis, Renal / Q000150:complications / Q000382:microbiology* / Q000473:pathology / Q000628:therapy
chemical_list: D000995:Antitubercular Agents; D004269:DNA, Bacterial; D013256:Steroids