A case of idiopathic adulthood ductopenia.
Idiopathic adulthood ductopenia (IAD) is a chronic cholestatic liver disease of unknown etiology characterized by adult onset, an absence of autoantibodies, inflammatory bowel disease, and a loss of interlobular bile ducts. In the present report, a case fulfilling the IAD criteria is described. A 19-year-old man was admitted to the hospital for persistent elevation of transaminases and alkaline phosphatase without clinical symptoms. Viral hepatitis markers and autoantibodies were absent. The patient had a normal extrahepatic biliary tree and had no evidence of inflammatory bowel disease. A liver biopsy specimen showed absence of interlobular bile ducts from 58% of the portal tracts. He was diagnosed with IAD and was treated with ursodeoxycholic acid.
Park
Byeong Chool
BC
Department of Internal Medicine, Chungbuk National University College of Medicine and Medical Research Institute, Cheongju, Korea.
Park
Seon Mee
SM
Choi
Eun Young
EY
Chae
Hee Bok
HB
Yoon
Se Jin
SJ
Sung
Rohyun
R
Lee
Sung Koo
SK
D000328:Adult; D002780:Cholestasis, Intrahepatic / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D002908:Chronic Disease; D006801:Humans; D008297:Male