title: Plasma surface modification of cyclo-olefin polymers and its application to lateral flow bioassays.
abstract: The modification of cyclo-olefin polymer Zeonor by plasma-enhanced chemical vapor deposition to form a silica-like surface and evaluation of its application for lateral flow bioassays applications are discussed in this study. The SiOx layer was extensively characterized using contact angle measurements, atomic force microscopy, and Fourier transform infrared spectroscopy in attenuated total internal reflectance mode where the presence of a uniform SiOx film was clearly identified. The SiOx modification resulted in a surface with enhanced wettability and excellent fluidic properties when combined with a hot-embossed micropillar capillary fill-based substrate. The SiOx surface also had the ability to accelerate the clotting of human plasma, which may have application in certain types of blood coagulation assays.
authors.affiliation: Biomedical Diagnostics Institute, National Centre for Sensor Research, Dublin City University, Dublin 9, Ireland.
authors.forename: Magdalena M
authors.initials: MM
authors.lastname: Dudek
authors.forename: R P
authors.initials: RP
authors.lastname: Gandhiraman
authors.forename: C
authors.initials: C
authors.lastname: Volcke
authors.forename: Attilio A
authors.initials: AA
authors.lastname: Cafolla
authors.forename: Stephen
authors.initials: S
authors.lastname: Daniels
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Killard
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D001681:Biological Assay; D001777:Blood Coagulation / Q000502:physiology; D005898:Glass / Q000737:chemistry; D006801:Humans; D018625:Microscopy, Atomic Force; D010949:Plasma / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D011137:Polystyrenes / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry; D012833:Siloxanes / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D013917:Thrombin / Q000378:metabolism; D017155:Wettability
chemical_list: D000475:Alkenes; D011108:Polymers; D011137:Polystyrenes; D012833:Siloxanes; D012822:Silicon Dioxide; C015917:hexamethyldisiloxane; D013917:Thrombin