Fatty acid synthesis and PPARalpha hand in hand.
How can an ex-orphan be adopted? Is it possible to do so by attributing to it a key endogenous ligand that regulates its central functions? In the recent issue of Cell, Chakravarthy et al. attempted to answer this question by characterizing a new physiologically relevant ligand for the ex-orphan receptor peroxisome proliferator activated receptor alpha (PPARalpha).
Rotman
Nicolas
N
Center for Integrative Genomics, National Research Center Frontiers in Genetics, University of Lausanne, Switzerland.
Wahli
Walter
W
D064429:Fatty Acid Synthases / Q000378:metabolism; D005227:Fatty Acids / Q000096:biosynthesis*; D008024:Ligands; D047493:PPAR alpha / Q000819:agonists / Q000378:metabolism*; D017855:Transferases (Other Substituted Phosphate Groups) / Q000378:metabolism
D005227:Fatty Acids; D008024:Ligands; D047493:PPAR alpha; D064429:Fatty Acid Synthases; D017855:Transferases (Other Substituted Phosphate Groups); C119514:choline-ethanolaminephosphotransferase