title: Synthesis of novel peptide linkers: simultaneous cyclization and labeling.
abstract: Synthesis of novel peptide linkers was accomplished by monocarboxylation of 1,3,5-tris(bomomethyl)benzene with a wide variety of carboxylic acids in the presence of diisopropylethylamine. These reagents can be used to simultaneously cyclize and label peptides containing two cysteines. Many labels are compatible with this method including lipids, fluorescent groups, and biotin.
authors.affiliation: Department of Chemistry and Massey Cancer Center, Virginia Commonwealth University, 401 College Street, Richmond, Virginia 23298-0037, USA.
authors.forename: Gajanan K
authors.initials: GK
authors.lastname: Dewkar
authors.forename: Pedro B
authors.initials: PB
authors.lastname: Carneiro
authors.forename: Matthew C T
authors.initials: MC
authors.lastname: Hartman
mesh_terms: D003500:Cyclization; D010455:Peptides / Q000737:chemistry*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D013194:Staining and Labeling; D013997:Time Factors; D014992:Xylenes / Q000737:chemistry
chemical_list: D010455:Peptides; D014992:Xylenes