title: Citrobacter koseri meningitis: a neurosurgical condition?
abstract: A 2-month-old girl developed meningitis, ventriculitis and brain abscess in the course of Citrobacter koseri infection. She was successfully treated with the combined use of antibiotics, intra-cavitary urokinase and surgery, thus avoiding the development of hydrocephalus and of ventricular loculation. C. koseri is a Gram-negative pathogen with a strong predilection for the neonatal brain. Brain abscesses develop in roughly 77% of cases, causing severe neurological sequels in one-half and death in one-third of patients. The authors aim to report the role of neurosurgical treatment for managing the severe complications that may arise in the course of C. koseri brain infection and the use of urokinase for preventing the development of loculated hydrocephalus.
authors.affiliation: Regional Service of Neurosurgery, Virgen de la Arrixaca University Hospital, 30120 El Palmar, Murcia, Spain. juanf.martinezlage@cablemurcia.com
authors.forename: Juan F
authors.initials: JF
authors.lastname: Martínez-Lage
authors.forename: Laura
authors.initials: L
authors.lastname: Martínez-Lage Azorín
authors.forename: María José
authors.initials: MJ
authors.lastname: Almagro
authors.forename: María Encarnación
authors.initials: ME
authors.lastname: Bastida
authors.forename: Susana
authors.initials: S
authors.lastname: Reyes
authors.forename: Cinthia
authors.initials: C
authors.lastname: Tellez
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D041041:Citrobacter koseri / Q000472:pathogenicity*; D004756:Enterobacteriaceae Infections / Q000188:drug therapy / Q000601:surgery*; D005260:Female; D006801:Humans; D007223:Infant
chemical_list: D000900:Anti-Bacterial Agents