title: Clozapine: acquittal of the usual suspect.
abstract: This report concerns the case of a 29-year-old male patient suffering from severe psychotic illness who had been satisfactorily treated with clozapine for 4 months. Clozapine had also been successfully administered during a psychotic episode 5 years previously. Though symptoms of psychosis were successfully controlled following the most recent psychotic episode, a medical consultation assessed that exacerbation of pancreatitis warranted discontinuation of the current antipsychotic treatment regime. Following a series of unsuccessful courses of neuroleptic medication, a magnetic resonance cholangiopancreaticography (MRCP) revealed marked cholecystolithiasis suggesting a biliary pancreatitis. Clozapine treatment was readministered following cholecystectomy. After 4 weeks of antipsychotic treatment the patient was discharged from hospital on clozapine monotherapy.
authors.affiliation: Department of Neurology, University of Bonn, Germany.
authors.forename: Tanja
authors.initials: T
authors.lastname: Schmitz-Hübsch
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Schlaepfer
authors.forename: Jens
authors.initials: J
authors.lastname: Westheide
authors.forename: Marcus
authors.initials: M
authors.lastname: von Falkenhausen
authors.forename: Deirdre
authors.initials: D
authors.lastname: Cooper-Mahkorn
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Maier
authors.forename: Kai-Uwe
authors.initials: KU
authors.lastname: Kühn
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D049448:Cholangiopancreatography, Magnetic Resonance; D002763:Cholecystectomy; D041761:Cholecystolithiasis / Q000601:surgery; D003024:Clozapine / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D010195:Pancreatitis / Q000473:pathology / Q000601:surgery; D011618:Psychotic Disorders / Q000188:drug therapy*; D028761:Withholding Treatment
chemical_list: D014150:Antipsychotic Agents; D003024:Clozapine