Ribosome shifting or splitting: it is all up to the EF-G.
Mitochondria possess two elongation factor Gs: one with translocation activity (EF-G1(mt)) and the other with no confirmed activity (EF-G2(mt)). Tsuboi et al. (2009) now show that the function of EF-G2(mt) is not in elongation but, rather, in ribosome recycling.
Christian
Brooke
B
Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3290, USA.
Haque
Emdadul
E
Spremulli
Linda
L
D006160:Guanosine Triphosphate / Q000378:metabolism; D006801:Humans; D006868:Hydrolysis; D008928:Mitochondria / Q000378:metabolism*; D024101:Mitochondrial Proteins / Q000096:biosynthesis* / Q000235:genetics / Q000378:metabolism; D010441:Peptide Chain Elongation, Translational; D020653:Peptide Elongation Factor G / Q000235:genetics / Q000378:metabolism*; D017434:Protein Structure, Tertiary; D021381:Protein Transport; D011994:Recombinant Proteins / Q000378:metabolism; D012269:Ribosomal Proteins / Q000235:genetics / Q000378:metabolism*; D012270:Ribosomes / Q000378:metabolism*
C441681:GFM2 protein, human; D024101:Mitochondrial Proteins; D020653:Peptide Elongation Factor G; D011994:Recombinant Proteins; D012269:Ribosomal Proteins; C087267:ribosome releasing factor; D006160:Guanosine Triphosphate