title: In vivo imaging of the cornea in a patient with lecithin-cholesterol acyltransferase deficiency.
abstract: OBJECTIVE
  To report high-resolution, in vivo imaging of the cornea in a patient with lecithin-cholesterol acyltransferase (LCAT) deficiency.
  
  
  METHODS
  A 60-year-old Ecuadorian woman with bilateral corneal opacities and confirmed LCAT deficiency was imaged with Fourier domain optical coherence tomography (FD-OCT) and noncontact Rostock confocal laser scanning microscopy.
  
  
  RESULTS
  The FD-OCT revealed a thinned epithelium, homogeneous hyperreflective stroma, and focal disruptions of Bowman's layer. Focal areas of hyperreflectivity with multiple dark striae and reduced and irregular keratocytes were seen throughout the stroma by noncontact Rostock module. The corneal endothelium was normal.
  
  
  CONCLUSIONS
  New anterior segment in vivo imaging technology permits high-resolutional visualization and monitoring of corneal pathology.
authors.affiliation: Einhorn Clinical Research Center, New York Eye and Ear Infirmary, New York, NY 10003, USA.
authors.forename: Pat-Michael
authors.initials: PM
authors.lastname: Palmiero
authors.forename: Zaher
authors.initials: Z
authors.lastname: Sbeity
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Liebmann
authors.forename: Robert
authors.initials: R
authors.lastname: Ritch
mesh_terms: D003315:Cornea / Q000473:pathology*; D003318:Corneal Opacity / Q000175:diagnosis* / Q000235:genetics; D005260:Female; D005583:Fourier Analysis; D007839:Functional Laterality; D006801:Humans; D007863:Lecithin Cholesterol Acyltransferase Deficiency / Q000175:diagnosis* / Q000235:genetics; D033401:Microscopy, Acoustic; D018613:Microscopy, Confocal; D008875:Middle Aged; D041623:Tomography, Optical Coherence