Synthesis and in vitro study of 14-aryl-14H-dibenzo[a.j]xanthenes as cytotoxic agents.
A simple and expedient method for the synthesis of a series of 14-aryl-14H-dibenzo[a.j]xanthenes is described through a one-pot condensation of beta-naphthol with aryl aldehydes catalysed by TaCl5 under solvent-free conventional heating. The major advantages of the present method are: high yields, less reaction time, solvent-free condition and easy purification of the products. The synthesized 14-aryl-14H-dibenzo[a.j]xanthenes were evaluated against a panel of six human cancer lines of different tissues. Synthesized compound 3o showed IC50 of 37.9 and 41.3 microM against Colo-205 and 502713, respectively, whereas 3g showed IC50 of 41.9 microM against Colo-205.
Bhattacharya
Asish K
AK
Division of Organic Chemistry and Combi Chem Bio-Resource Centre, National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411 008, India. ak.bhattacharya@ncl.res.in
Rana
Kalpeshkumar C
KC
Mujahid
Mohammad
M
Sehar
Irum
I
Saxena
Ajit K
AK
D000447:Aldehydes / Q000737:chemistry; D002384:Catalysis; D045744:Cell Line, Tumor; D002712:Chlorides / Q000737:chemistry; D003603:Cytotoxins / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009284:Naphthols / Q000737:chemistry; D013635:Tantalum / Q000737:chemistry; D014966:Xanthenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity
D000447:Aldehydes; D002712:Chlorides; D003603:Cytotoxins; D009284:Naphthols; D014966:Xanthenes; C437166:tantalum chloride; D013635:Tantalum; C028405:2-naphthol