Enzyme-instructed molecular self-assembly confers nanofibers and a supramolecular hydrogel of taxol derivative.
By covalently connecting taxol with a motif that is prone to self-assemble, we successfully generate the precursor (5a), the hydrogelator (5b), and hydrogel of a taxol derivative without compromising the cytotoxic activity of the taxol. This approach promises a general method to create nanofibers of therapeutic molecules that have a dual role, as both the delivery vehicle and the drug itself.
Gao
Yuan
Y
Department of Chemistry, Brandeis University, 415 South Street, Waltham, Massachusetts 02454, USA.
Kuang
Yi
Y
Guo
Zu-Feng
ZF
Guo
Zhihong
Z
Krauss
Isaac J
IJ
Xu
Bing
B
D000469:Alkaline Phosphatase / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000138:chemical synthesis* / Q000737:chemistry; D049329:Nanostructures / Q000737:chemistry*; D017239:Paclitaxel / Q000737:chemistry*; D050257:Tubulin Modulators / Q000737:chemistry*
D000972:Antineoplastic Agents, Phytogenic; D050257:Tubulin Modulators; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D000469:Alkaline Phosphatase; D017239:Paclitaxel