Population structure dynamics of Mycobacterium tuberculosis Beijing strains during past decades in Japan.
We used 909 strains to compare the population structures of the Mycobacterium tuberculosis Beijing family between different birth-year cohorts in Japan. The results revealed that the spread of a modern sublineage that has high transmissibility is currently increasing, while the spread of an ancient sublineage, STK, has significantly decreased in younger generations.
Iwamoto
Tomotada
T
Department of Microbiology, Kobe Institute of Health, Kobe, Japan. kx2t-iwmt@asahi-net.or.jp
Fujiyama
Riyo
R
Yoshida
Shiomi
S
Wada
Takayuki
T
Shirai
Chika
C
Kawakami
Yasuto
Y
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015373:Bacterial Typing Techniques; D005260:Female; D005838:Genotype; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D017720:Molecular Epidemiology; D009169:Mycobacterium tuberculosis / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D014376:Tuberculosis / Q000453:epidemiology* / Q000382:microbiology* / Q000635:transmission