title: A 5-year-old boy with unicentric Castleman disease affecting the mesentery: utility of serum IL-6 level and (18)F-FDG PET for diagnosis.
abstract: Castleman disease (CD) is a rare lymphoproliferative disorder of unknown etiology. It is quite difficult to diagnose CD without typical localized signs or symptoms. We present a 5-year-old boy with unicentric plasma cell CD in the mesentery, which was too small to be detected by any conventional imaging. (18)F-fluorodeoxyglucose positron emission tomography image and a serum cytokine profile prompted us to perform a curative surgical excision, confirming his diagnosis. Our case also supported an important role of interleukin-6 in the pathophysiology of plasma cell CD.
authors.affiliation: Department of Pediatrics, Graduate School of Medicine, Japan.
authors.forename: Nariaki
authors.initials: N
authors.lastname: Toita
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Kawamura
authors.forename: Norikazu
authors.initials: N
authors.lastname: Hatano
authors.forename: Syun-ichiro
authors.initials: S
authors.lastname: Takezaki
authors.forename: Yuka
authors.initials: Y
authors.lastname: Ohkura
authors.forename: Masafumi
authors.initials: M
authors.lastname: Yamada
authors.forename: Motohiko
authors.initials: M
authors.lastname: Okano
authors.forename: Tadao
authors.initials: T
authors.lastname: Okada
authors.forename: Fumiaki
authors.initials: F
authors.lastname: Sasaki
authors.forename: Kanako C
authors.initials: KC
authors.lastname: Kubota
authors.forename: Tomoo
authors.initials: T
authors.lastname: Itoh
authors.forename: Tadashi
authors.initials: T
authors.lastname: Ariga
mesh_terms: D005871:Castleman Disease / Q000097:blood / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery; D002675:Child, Preschool; D005334:Fever / Q000209:etiology; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D006801:Humans; D015850:Interleukin-6 / Q000097:blood* / Q000235:genetics / Q000502:physiology; D008197:Lymph Node Excision; D008297:Male; D008643:Mesentery / Q000000981:diagnostic imaging*; D010950:Plasma Cells / Q000473:pathology; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals
chemical_list: D005462:Fluorine Radioisotopes; C508600:IL6 protein, human; D015850:Interleukin-6; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18