Laboratory-based surveillance of Streptococcus pneumoniae invasive disease in children in 10 Latin American countries: a SIREVA II project, 2000-2005.
BACKGROUND
For the last 14 years the Pan American Health Organization has been promoting surveillance of invasive pneumococcal disease in Latin American children for better understanding of the disease tendencies regarding capsular types circulation in each country and susceptibility to antimicrobials.


METHODS
Laboratory-based surveillance data from 10 Latin American countries collected from 2000 to 2005 were analyzed, including serotype distribution and susceptibility to beta-lactam antibiotics.


RESULTS
Although 61 different capsular types were identified during the 6-year surveillance, 13 serotypes accounted for 86% of all isolates. These were consistently the most prevalent throughout the study period with serotype 14 predominating. Diminished susceptibility to penicillin was detected in 38% of all Streptococcus pneumoniae isolates, with the highest prevalence in Dominican Republic and Mexico. Decreased susceptibility to penicillin increased in Brazil and Colombia whereas decreased high resistance rates was recorded in Chile.


CONCLUSIONS
These data indicate that 10 countries of the Region continue to have high quality laboratory-based surveillance for pneumococcal disease thus generating valuable information so that healthcare decision makers may prioritize interventions. The heptavalent vaccine will potentially cover from 52.4% to 76.5% of strains causing invasive pneumococcal disease and the 13 valent from 76.7% to 88.3%.
Castañeda
Elizabeth
E
Grupo de Microbiologia, Instituto Nacional de Salud, Bogotá, Colombia. ecastaneda21@gmail.com
Agudelo
Clara I
CI
Regueira
Mabel
M
Corso
Alejandra
A
Brandileone
Maria C de Cunto
MC
Brandão
Angela P
AP
Maldonado
Aurora
A
Hormazabal
Juan C
JC
Martínez
Isis T
IT
Llanes
Rafael
R
Sánchez
Jacqueline
J
Feris
Jesús M
JM
Echaniz-Aviles
Gabriela
G
Carnalla-Barajas
María N
MN
Terrazas
Mónica G V
MG
Monroy
Irma H
IH
Chamorro
Gustavo
G
Weiler
Natalie
N
Camou
Teresa
T
Gabarrot
Gabriela G
GG
Spadola
Enza
E
Payares
Daisy
D
Gabastou
Jean M
JM
Di Fabio
José Luis
JL
de la Hoz
Fernando
F
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D015373:Bacterial Typing Techniques; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007843:Latin America / Q000453:epidemiology; D008297:Male; D008826:Microbial Sensitivity Tests; D010403:Penicillin Resistance; D011008:Pneumococcal Infections / Q000453:epidemiology* / Q000382:microbiology*; D011159:Population Surveillance / Q000379:methods; D015995:Prevalence; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000145:classification* / Q000187:drug effects / Q000302:isolation & purification*; D047090:beta-Lactams / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D047090:beta-Lactams