title: Adult community-acquired pneumonia caused by macrolide resistant Mycoplasma pneumoniae.
abstract: A 28-year-old woman with community-acquired pneumonia was treated with sulbactam/ampicillin and clarithromycin, but failed to show any improvement after 4 days. The antibiotic regimen was changed to pazufloxacin and rapid clinical improvement was seen. Mycoplasma pneumoniae was identified as the causative agent, and adenine (A) to guanine (G) mutation at position 2063 in domain V of the 23S rRNA was noted in the isolate. The minimum inhibitory concentration of macrolide antibiotics, including clarithromycin, of this isolate was greatly elevated.
authors.affiliation: Inoue Hospital, Nagasaki 850-0045, Japan. wushiqilihui@hotmail.co.jp
authors.forename: Rie
authors.initials: R
authors.lastname: Isozumi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Yoshimine
authors.forename: Miyuki
authors.initials: M
authors.lastname: Morozumi
authors.forename: Kimiko
authors.initials: K
authors.lastname: Ubukata
authors.forename: Koya
authors.initials: K
authors.lastname: Ariyoshi
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use; D017714:Community-Acquired Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology*; D024881:Drug Resistance, Bacterial; D005260:Female; D006801:Humans; D018942:Macrolides / Q000494:pharmacology / Q000627:therapeutic use; D009177:Mycoplasma pneumoniae / Q000187:drug effects / Q000472:pathogenicity*; D018410:Pneumonia, Bacterial / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology*; D011019:Pneumonia, Mycoplasma / Q000175:diagnosis* / Q000188:drug therapy; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D018942:Macrolides