Extragenital adenosarcoma: a case report, review of the literature, and management discussion.
BACKGROUND
Müllerian adenosarcoma is a rare mixed epithelial-mesenchymal tumor. An extragenital site of origin and sarcomatous overgrowth are associated with aggressive clinical behavior.


METHODS
We present a rare case of extragenital adenosarcoma with sarcomatous overgrowth and coexistent endometriosis. She was treated with initial cytoreductive surgery and chemotherapy. She underwent a second surgery for management of a high-grade bowel obstruction, due to pathologically confirmed recurrent intraperitoneal adenosarcoma. A complete clinical response was achieved with liposomal doxorubicin, and the patient remains disease-free eighteen months after completion of chemotherapy.


CONCLUSIONS
Liposomal doxorubicin appears to be an active agent for the treatment of adenosarcoma with sarcomatous overgrowth. In addition, we conclude from our review of all reported cases of extragenital adenosarcoma that concurrent endometriosis may represent a favorable prognostic factor.
Huang
Gloria S
GS
Division of Gynecologic Oncology, Department of Obstetrics & Gynecology and Women's Health, Department of Pathology, Albert Einstein College of Medicine and Montefiore Medical Center, Albert Einstein Cancer Center, 1695 Eastchester Road, Suite 601, Bronx, NY 10461, USA. ghuang@montefiore.org
Arend
Rebecca C
RC
Sakaris
Antoinette
A
Hebert
Tiffany M
TM
Goldberg
Gary L
GL
D018195:Adenosarcoma / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*; D000328:Adult; D004715:Endometriosis / Q000473:pathology; D005260:Female; D005833:Genital Neoplasms, Female / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*; D006801:Humans