title: Scientific and ethical issues related to deep brain stimulation for disorders of mood, behavior, and thought.
abstract: BACKGROUND
  A 2-day consensus conference was held to examine scientific and ethical issues in the application of deep brain stimulation for treating mood and behavioral disorders, such as major depression, obsessive-compulsive disorder, and Tourette syndrome.
  
  
  OBJECTIVE
  The primary objectives of the conference were to (1) establish consensus among participants about the design of future clinical trials of deep brain stimulation for disorders of mood, behavior, and thought and (2) develop standards for the protection of human subjects participating in such studies.
  
  
  RESULTS
  Conference participants identified 16 key points for guiding research in this growing field.
  
  
  CONCLUSIONS
  The adoption of the described guidelines would help to protect the safety and rights of research subjects who participate in clinical trials of deep brain stimulation for disorders of mood, behavior, and thought and have further potential to benefit other stakeholders in the research process, including clinical researchers and device manufactures. That said, the adoption of the guidelines will require broad and substantial commitment from many of these same stakeholders.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Johns Hopkins Hospital, Baltimore, MD 21205, USA.
authors.forename: Peter
authors.initials: P
authors.lastname: Rabins
authors.forename: Brian S
authors.initials: BS
authors.lastname: Appleby
authors.forename: Jason
authors.initials: J
authors.lastname: Brandt
authors.forename: Mahlon R
authors.initials: MR
authors.lastname: DeLong
authors.forename: Laura B
authors.initials: LB
authors.lastname: Dunn
authors.forename: Loes
authors.initials: L
authors.lastname: Gabriëls
authors.forename: Benjamin D
authors.initials: BD
authors.lastname: Greenberg
authors.forename: Suzanne N
authors.initials: SN
authors.lastname: Haber
authors.forename: Paul E
authors.initials: PE
authors.lastname: Holtzheimer
authors.forename: Zoltan
authors.initials: Z
authors.lastname: Mari
authors.forename: Helen S
authors.initials: HS
authors.lastname: Mayberg
authors.forename: Evelyn
authors.initials: E
authors.lastname: McCann
authors.forename: Sallie P
authors.initials: SP
authors.lastname: Mink
authors.forename: Steven
authors.initials: S
authors.lastname: Rasmussen
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Schlaepfer
authors.forename: Dorothy E
authors.initials: DE
authors.lastname: Vawter
authors.forename: Jerrold L
authors.initials: JL
authors.lastname: Vitek
authors.forename: John
authors.initials: J
authors.lastname: Walkup
authors.forename: Debra J H
authors.initials: DJ
authors.lastname: Mathews
mesh_terms: D002986:Clinical Trials as Topic / Q000941:ethics* / Q000379:methods; D046690:Deep Brain Stimulation / Q000941:ethics* / Q000379:methods; D003866:Depressive Disorder / Q000628:therapy; D032984:Ethics, Research; D006801:Humans; D001523:Mental Disorders / Q000628:therapy*; D009771:Obsessive-Compulsive Disorder / Q000628:therapy; D005879:Tourette Syndrome / Q000628:therapy