[Assessment of antiviral immunity in pregnant women with mixed infection (HIV + CMV), living in Surgut].
Concomitant cytomegalovirus infection (CMVI), a classical opportunistic infection, is an important problem among HIV-infection pregnant women. CMVI in pregnant women runs mainly in the latent form with reactivation under physiological immunosuppression. Therefore the evaluation of immunoresponsiveness in HIV-infected pregnant women with mixed (HIV + CMV) infection becomes to be of particular urgency. Sixty-five women who were registered in the antenatal clinic of Surgut and its anti-AIDS center in 2005-2007 were examined. The examinees' sera were tested for CMV antibody titers by heterogenous solid-phase enzyme immunoassay (EIA) to determine the moment of infection and differentiation of primary infection, reinfection, or infectious process reactivation. Assay of plasma CMV DNA was carried out by the polymerase chain reaction technique to evaluate the activity of CMVI. The high spread of serological CMVI markers in the pregnant women of the Middle Ob Region necessitates monitoring this group, by obligatorily determining IgM, IgG, and their avidity.
Kovaleva
N E
NE
Bakhlykova
N Iu
NIu
Bazarnyĭ
V V
VV
D017088:AIDS-Related Opportunistic Infections / Q000097:blood / Q000453:epidemiology / Q000276:immunology* / Q000821:virology; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood*; D000915:Antibody Affinity; D002947:Cities; D003586:Cytomegalovirus Infections / Q000097:blood / Q000453:epidemiology / Q000276:immunology* / Q000821:virology; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D005865:Gestational Age; D015658:HIV Infections / Q000097:blood / Q000453:epidemiology / Q000276:immunology* / Q000821:virology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000097:blood / Q000453:epidemiology / Q000276:immunology* / Q000821:virology; D012800:Siberia / Q000453:epidemiology
D000914:Antibodies, Viral; D004279:DNA, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M