title: Palladium- and copper-catalyzed solution phase synthesis of a diverse library of isoquinolines.
abstract: The solution-phase synthesis of a 111 member isoquinoline library is described. The isoquinoline scaffold has been accessed through the palladium- and copper-catalyzed cyclization of iminoalkynes and the palladium-catalyzed iminoannulation of internal alkynes, followed by diversification of hydroxyl functionality where it is present.
authors.affiliation: Department of Chemistry, Iowa State University, Ames, Iowa 50011, USA.
authors.forename: Sudipta
authors.initials: S
authors.lastname: Roy
authors.forename: Sujata
authors.initials: S
authors.lastname: Roy
authors.forename: Benjamin
authors.initials: B
authors.lastname: Neuenswander
authors.forename: David
authors.initials: D
authors.lastname: Hill
authors.forename: Richard C
authors.initials: RC
authors.lastname: Larock
mesh_terms: D002384:Catalysis; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D008970:Molecular Weight; D009942:Organometallic Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D054852:Small Molecule Libraries; D012996:Solutions; D013237:Stereoisomerism
chemical_list: D007546:Isoquinolines; D009942:Organometallic Compounds; D054852:Small Molecule Libraries; D012996:Solutions; D010165:Palladium; D003300:Copper