title: The DESIRE study--psoriasis patients' satisfaction with topical treatment using a fixed combination of calcipotriol and betamethasone dipropionate in daily clinical practice.
abstract: Daivobet (Dovobet) is a fixed combination ointment of calcipotriol and betamethasone dipropionate. The real-life clinical use of calcipotriol/betamethasone dipropionate treatment was assessed in this multi-centre, single-group, non-interventional study. Patients with psoriasis vulgaris who had a recent calcipotriol/betamethasone dipropionate prescription prior to the study start evaluated their satisfaction with the treatment after a 4-week course and after repeated courses for up to 6 months. Of the 1224 patients enrolled, 81.5% completed the 6-month study period. Approximately 75% of the patients were satisfied/very satisfied after one calcipotriol/betamethasone dipropionate treatment course and the satisfaction was high regardless of initial disease severity. Repeated calcipotriol/betamethasone dipropionate courses were prescribed for 22.9% of the patients and treatment satisfaction remained high (about 80%). The majority (60%) of the patients were willing to provide co-payments for calcipotriol/betamethasone dipropionate within their national health insurance system.
authors.affiliation: Läkarhuset Farsta Centrum, Hudmottagningen, Karlandaplan 6, 123 47 Farsta, Sweden.
authors.forename: Birgitta Wilson
authors.initials: BW
authors.lastname: Claréus
authors.forename: Ronald
authors.initials: R
authors.lastname: Houwing
authors.forename: Jens H
authors.initials: JH
authors.lastname: Sindrup
authors.forename: Suzanne
authors.initials: S
authors.lastname: Wigchert
mesh_terms: D000279:Administration, Cutaneous; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D001623:Betamethasone / Q000008:administration & dosage / Q000031:analogs & derivatives*; D002117:Calcitriol / Q000008:administration & dosage / Q000031:analogs & derivatives*; D003718:Denmark; D003879:Dermatologic Agents / Q000008:administration & dosage*; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008189:Luxembourg; D008297:Male; D008875:Middle Aged; D009426:Netherlands; D009824:Ointments / Q000008:administration & dosage; D017060:Patient Satisfaction; D011565:Psoriasis / Q000188:drug therapy* / Q000473:pathology; D011788:Quality of Life; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013548:Sweden; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D003879:Dermatologic Agents; D004338:Drug Combinations; D009824:Ointments; C517164:betamethasone dipropionate, calcipotriol drug combination; D001623:Betamethasone; D002117:Calcitriol