title: Phase I study of concurrent selective lymph node late course accelerated hyper-fractionated radiotherapy and Capecitabine, Cisplatin for locally advanced esophageal squamous cell carcinoma.
abstract: Twelve patients with locally advanced esophageal squamous cell carcinoma were enrolled to evaluate the safety and efficacy of concurrent chemo-radiotherapy. Dose-limiting toxicity was mainly observed at Capecitabine 1500 mg. The maximum-tolerated dose/recommended dose of Capecitabine was 1000 mg. The Kaplan-Meier estimated overall l-year survival rate was 100%.
authors.affiliation: Sixth Department of Radiation Oncology, Shandong Cancer Hospital, Shandong Province, PR China.
authors.forename: Bao-sheng
authors.initials: BS
authors.lastname: Li
authors.forename: Tao
authors.initials: T
authors.lastname: Zhou
authors.forename: Zhong-tang
authors.initials: ZT
authors.lastname: Wang
authors.forename: Hong-sheng
authors.initials: HS
authors.lastname: Li
authors.forename: Hong-fu
authors.initials: HF
authors.lastname: Sun
authors.forename: Zhi-cheng
authors.initials: ZC
authors.lastname: Zhang
authors.forename: Hai-qun
authors.initials: HQ
authors.lastname: Lin
authors.forename: Yu-mei
authors.initials: YM
authors.lastname: Wei
authors.forename: He-yi
authors.initials: HY
authors.lastname: Gong
authors.forename: Wei
authors.initials: W
authors.lastname: Huang
authors.forename: Yan
authors.initials: Y
authors.lastname: Yi
authors.forename: Li-ying
authors.initials: LY
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D000069287:Capecitabine; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000401:mortality / Q000532:radiotherapy*; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D019583:Dose Fractionation, Radiation; D004938:Esophageal Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000532:radiotherapy*; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000031:analogs & derivatives; D006801:Humans; D015182:Lymphatic Irradiation; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D011832:Radiation Injuries; D011879:Radiotherapy Dosage; D050397:Radiotherapy, Intensity-Modulated; D015996:Survival Rate
chemical_list: D003841:Deoxycytidine; D000069287:Capecitabine; D002945:Cisplatin; D005472:Fluorouracil