title: Herpes simplex virus type 2 and HIV infection among US military personnel: implications for health prevention programmes.
abstract: US military personnel are routinely screened for HIV infection. Herpes simplex virus type 2 (HSV-2) is a risk factor for HIV acquisition. To determine the association between HSV-2 and HIV, a matched case-control study was conducted among US Army and Air Force service members with incident HIV infections (cases) randomly matched with two HIV-uninfected service members (controls) between 2000 and 2004. HSV-2 prevalence was significantly higher among cases (30.3%, 138/456) than among controls (9.7%, 88/912, P < 0.001). HSV-2 was strongly associated with HIV in univariate (odds ratio [OR] = 4.2, 95% confidence interval [CI] = 3.1-5.8) and multiple analyses (adjusted [OR] = 3.9, 95% CI = 2.8-5.6). The population attributable risk percentage of HIV infection due to HSV-2 was 23%. Identifying HSV-2 infections may afford the opportunity to provide targeted behavioural interventions that could decrease the incidence of HIV infections in the US military population; further studies are needed.
authors.affiliation: US Military HIV Research Program, Division of Retrovirology, Walter Reed Army Institute of Research (WRAIR), Suite 250, Rockville, MD 20850, USA. cbautista@hivresearch.org
authors.forename: C T
authors.initials: CT
authors.lastname: Bautista
authors.forename: D E
authors.initials: DE
authors.lastname: Singer
authors.forename: R J
authors.initials: RJ
authors.lastname: O'Connell
authors.forename: N
authors.initials: N
authors.lastname: Crum-Cianflone
authors.forename: B K
authors.initials: BK
authors.lastname: Agan
authors.forename: J A
authors.initials: JA
authors.lastname: Malia
authors.forename: J L
authors.initials: JL
authors.lastname: Sanchez
authors.forename: S A
authors.initials: SA
authors.lastname: Peel
authors.forename: N L
authors.initials: NL
authors.lastname: Michael
authors.forename: P T
authors.initials: PT
authors.lastname: Scott
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D016022:Case-Control Studies; D005260:Female; D015658:HIV Infections / Q000209:etiology* / Q000517:prevention & control; D006558:Herpes Genitalis / Q000150:complications / Q000453:epidemiology*; D006801:Humans; D008297:Male; D008889:Military Personnel; D015995:Prevalence; D012307:Risk Factors