Therapeutic opportunities of small interfering RNA.
Formation of small interfering RNA (siRNA) occurs in two steps involving binding of the RNA nucleases to a large double-stranded RNA (dsRNA) and its cleavage into fragments called siRNA. In the second step, these siRNAs join a multinuclease complex, which degrades the homologous single-stranded mRNAs. The delivery of siRNA involves viral- and non-viral-mediated delivery systems; the approaches for chemical modifications have also been developed. It has various therapeutic applications for disorders like cardiovascular diseases, central nervous system (CNS) disorders, cancer, human immunodeficiency virus (HIV), hepatic disorders, etc. The present review gives an overview of the applications of siRNA and their potential for treating many hitherto untreatable diseases.
Goyal
Bhoomika R
BR
Institute of Pharmacy, Nirma University of Science and Technology, Ahmedabad 382 481, Gujarat, India. bgoyal@rediffmail.com
Patel
Mayur M
MM
Soni
Mithil K
MK
Bhadada
Shraddha V
SV
D000818:Animals; D018014:Gene Transfer Techniques; D005822:Genetic Vectors; D006801:Humans; D034622:RNA Interference; D012330:RNA, Double-Stranded / Q000378:metabolism; D034741:RNA, Small Interfering / Q000627:therapeutic use*
D012330:RNA, Double-Stranded; D034741:RNA, Small Interfering