title: eEF1A2 as a putative oncogene.
abstract: The first evidence for the role of the protein elongation factor eEF1A2 in tumorigenesis was reported by Anand and colleagues who demonstrated that eEF1A2 is overexpressed in about 30% of ovarian tumors and some established ovarian cancer cells. This abnormal expression correlates with a poor prognosis. Since this discovery, there have been several reports suggesting eEF1A2 as a diagnostic marker in various cancers. This review highlights the oncogenic potential of eEF1A2.
authors.affiliation: National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy and Cancer Research Institute, Seoul National University, Seoul, Korea.
authors.forename: Mee-Hyun
authors.initials: MH
authors.lastname: Lee
authors.forename: Young-Joon
authors.initials: YJ
authors.lastname: Surh
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics; D001943:Breast Neoplasms / Q000235:genetics / Q000473:pathology*; D005260:Female; D005784:Gene Amplification; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009857:Oncogenes / Q000235:genetics*; D010051:Ovarian Neoplasms / Q000235:genetics / Q000473:pathology*; D020648:Peptide Elongation Factor 1 / Q000235:genetics*; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; C503234:EEF1A2 protein, human; D020648:Peptide Elongation Factor 1