Determinants of pregnancy rate in the donor oocyte model: a multivariate analysis of 450 frozen-thawed embryo transfers.
BACKGROUND
Conflicting results have been published about the determinants of pregnancy after oocyte donation (OD). We used the OD model to determine predictive factors of pregnancy in the recipient after frozen-thawed embryo transfer (FTET) in a specific series where all the embryos were cryopreserved without any prior selection for fresh transfer.


METHODS
We report a retrospective study in a university tertiary care center. Multivariate analysis and logistic regression were used to identify predictive factors of pregnancy in a series of 450 OD FTET cycles in 198 infertile women between January 1992 and December 2006.


RESULTS
The mean (+/-SD) recipient age was 35.7 (+/-4.5). Impaired ovarian function was the main indication for OD. The mean +/- SD (range) number of embryos transferred was 1.65 +/- 0.5 (1-3). Overall clinical pregnancy, implantation and delivery rates were 30, 18 and 23%, respectively. After univariate analysis, pregnancy rates were significantly higher in recipients under 35 years, in women with a body mass index (BMI) <30 kg/m(2), in women with an endometrial thickness of > or =8 mm, in amenorrheic women and in women not receiving pituitary down-regulation before endometrial preparation. Using multivariate analysis, the BMI, endometrial thickness and the use of pituitary down-regulation were independent predictors of pregnancy, regardless of age.


CONCLUSIONS
This study supports that endometrial thickness of <8 mm, obesity and the use of GnRH analogue pituitary down-regulation before endometrial priming negatively impact pregnancy rates, independently of the recipient's age.
Dessolle
Lionel
L
Service de gynécologie obstétrique et médecine de la reproduction, Hôpital TENON, 75020 Paris, France. lionel.dessolle@tnn.aphp.fr
Daraï
Emile
E
Cornet
Dominique
D
Rouzier
Roman
R
Coutant
Charles
C
Mandelbaum
Jacqueline
J
Antoine
Jean-Marie
JM
D000293:Adolescent; D000328:Adult; D000375:Aging; D003140:Communicable Disease Control / Q000331:legislation & jurisprudence; D015925:Cryopreservation; D004624:Embryo Transfer / Q000706:statistics & numerical data*; D004717:Endometrium / Q000033:anatomy & histology; D005260:Female; D005602:France; D007987:Gonadotropin-Releasing Hormone / Q000009:adverse effects / Q000031:analogs & derivatives; D006801:Humans; D007246:Infertility / Q000150:complications / Q000628:therapy*; D015999:Multivariate Analysis; D009765:Obesity / Q000150:complications; D018587:Oocyte Donation / Q000706:statistics & numerical data*; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D013223:Statistics as Topic; D013997:Time Factors; D055815:Young Adult
D007987:Gonadotropin-Releasing Hormone