A neocentric isochromosome Yp present as additional small supernumerary marker chromosome--evidence against U-type exchange mechanism?
Here we report the first case of an inverted duplicated neocentric small supernumerary marker chromosome present in a karyotype 47,XX,+mar(Y). As expected a partial disomy of Ypter to Yp11.2 did not lead to any major malformations. However, the formation of an inverted duplicated chromosome from a Y chromosome is not possible by a U-type exchange, as has been suggested for such kind of neocentric marker chromosomes. Thus, some evidence is here provided that this concept might not always be true.
Sheth
F
F
Institute of Human Genetics, Foundation for Research in Genetics and Endocrinology (FRIGE), Ahmedabad, India.
Ewers
E
E
Kosyakova
N
N
Weise
A
A
Sheth
J
J
Patil
S
S
Ziegler
M
M
Liehr
T
T
D002869:Chromosome Aberrations; D041322:Chromosomes, Human, Y; D005260:Female; D005819:Genetic Markers; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D018404:Isochromosomes; D007621:Karyotyping; D008297:Male
D005819:Genetic Markers