Caffeine consumption and miscarriage: a prospective cohort study.
Caffeine consumption has been equivocally associated with miscarriage, despite an absence of prospective longitudinal measurement of caffeine intake during sensitive windows of human development. In response to this critical data gap, we analyzed daily caffeine consumption while attempting pregnancy through 12 menstrual cycles at risk for pregnancy and found that caffeine consumption did not increase the risk or hazard of miscarriage, even after adjusting for relevant covariates.
Pollack
Anna Z
AZ
Epidemiology Branch, Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rockville, Maryland 20852, USA.
Buck Louis
Germaine M
GM
Sundaram
Rajeshwari
R
Lum
Kirsten J
KJ
D000022:Abortion, Spontaneous / Q000139:chemically induced*; D001628:Beverages; D002110:Caffeine / Q000009:adverse effects*; D000697:Central Nervous System Stimulants / Q000009:adverse effects*; D005260:Female; D006801:Humans; D011247:Pregnancy; D016016:Proportional Hazards Models; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors
D000697:Central Nervous System Stimulants; D002110:Caffeine