title: Disruption of transepithelial resistance by enterotoxigenic Escherichia coli.
abstract: Transepithelial resistance and tight junction protein localization in porcine intestinal epithelial cells were evaluated as a function of infection with porcine enterotoxigenic Escherichia coli isolates differing in adhesin and enterotoxin profiles. Robust heat-labile enterotoxin-independent reduction of host transepithelial resistance was observed in the absence of tight junction protein mislocalization.
authors.affiliation: Department of Veterinary Science, South Dakota State University, Brookings, SD 57007, USA.
authors.forename: Amber M
authors.initials: AM
authors.lastname: Johnson
authors.forename: Radhey S
authors.initials: RS
authors.lastname: Kaushik
authors.forename: Philip R
authors.initials: PR
authors.lastname: Hardwidge
mesh_terms: D000818:Animals; D015153:Blotting, Western; D002460:Cell Line; D054307:Enterotoxigenic Escherichia coli / Q000502:physiology*; D004847:Epithelial Cells / Q000382:microbiology*; D007422:Intestines / Q000166:cytology / Q000382:microbiology; D008856:Microscopy, Fluorescence; D013552:Swine; D019108:Tight Junctions / Q000382:microbiology