title: Successful use of recombinant factor VIIa in a preterm infant with life-threatening haematuria.
abstract: We report the case of a preterm male infant with a gestational age of 28 + 1 weeks and birth weight of 715 g who presented with life-threatening haematuria on day 28 of life. The haematuria was unresponsive to administration of platelet concentrates and fresh frozen plasma, but then successfully treated with recombinant factor VIIa. The resulting obstructive uropathy was managed by continuous bladder irrigation through suprapubic and urethral catheters. No other adverse affects were noted, and the boy was discharged from the hospital on day 108 of life.
authors.affiliation: Department of Children's and Adolescent's Medicine, University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany. faust@paedia.ukl.mu-luebeck.de
authors.forename: Kirstin
authors.initials: K
authors.lastname: Faust
authors.forename: Birthe
authors.initials: B
authors.lastname: Tröger
authors.forename: Fritz
authors.initials: F
authors.lastname: Kahl
authors.forename: Marius
authors.initials: M
authors.lastname: Schumacher
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Göpel
authors.forename: Christoph
authors.initials: C
authors.lastname: Härtel
mesh_terms: D016638:Critical Illness; D015942:Factor VIIa / Q000627:therapeutic use*; D006417:Hematuria / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D011994:Recombinant Proteins / Q000627:therapeutic use; D016896:Treatment Outcome; D014524:Urethral Obstruction / Q000209:etiology / Q000628:therapy
chemical_list: D011994:Recombinant Proteins; C103587:recombinant FVIIa; D015942:Factor VIIa