[Effect of modified Yupingfeng granule on nuclear factor-kappaB expression in mice with allergic contact dermatitis].
OBJECTIVE
To investigate the effect of modified Yupingfeng granule on nuclear factor-kappaB (NF-kappaB)expression in mice with allergic contact dermatitis (ACD).


METHODS
Mouse models of ACD were treated with the granules at low, medium and high doses, with normal saline and hydrocortisone as the negative and positive controls, respectively. The expressions of NF-kappaB and its distribution in the lesions were detected using immunohistochemistry.


RESULTS
The staining intensity, area and positive expression rates of NF-kappaB p50 were significantly different between the treatment group and the normal saline group (P<0.05).


CONCLUSIONS
Modified Yupingfeng granule can effectively inhibit the expression of NF-kappaB in ACD, which might be a possible mechanism for its therapeutic effect on ACD.
Li
Li
L
Department of Dermatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Liang
Liu-ping
LP
Hou
Gui-rong
GR
Luo
Ren
R
D000818:Animals; D017449:Dermatitis, Allergic Contact / Q000188:drug therapy / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D005786:Gene Expression Regulation / Q000187:drug effects*; D051379:Mice; D008807:Mice, Inbred BALB C; D016328:NF-kappa B / Q000378:metabolism*
D004365:Drugs, Chinese Herbal; D016328:NF-kappa B; C532967:yupingfeng