Association of polymorphisms in apolipoprotein A1 and apolipoprotein B genes with lipid profile in Tamilian population.
To study the influence of ApoAI and ApoB gene polymorphisms on lipid profile in healthy Tamilian volunteers of south India. Genotyping of ApoAI and ApoB polymorphisms was done in 185 subjects by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) method.The frequency of the M1-, M2- and R- alleles were 21%, 4.3% and 5.4% respectively and were similar to that reported from Asian Indians. An increase of 9.1mg/dl in HDL-C levels was observed with M1-/- genotype when compared to M1+/+. A paradoxical increase in levels of total cholesterol and LDL-C was observed with M2+7divide;- genotype when compared to M2+/+ genotype. Analysis of combination of genotypes of ApoAI revealed no influence on the lipid parameters. ApoB EcoRI had no significant effect on lipid profile. For the first time genotype distribution of ApoAI and ApoB polymorphisms and their effect on lipid profile was established in Tamilians. Only -75G/A polymorphism of ApoAI was significantly associated with HDL7ndash;C levels.
Padmaja
N
N
Pharmacogenomics Laboratory, Department of Pharmacology, Jawaharlal Institute of Post-graduate Medical Education and Research, Pondicherry, India. padmaja_25@yahoo.com
Kumar
M Ravindra
MR
Adithan
C
C
D016632:Apolipoprotein A-I / Q000235:genetics*; D001055:Apolipoproteins B / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D008076:Cholesterol, HDL / Q000097:blood / Q000235:genetics; D008078:Cholesterol, LDL / Q000097:blood / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic
D016632:Apolipoprotein A-I; D001055:Apolipoproteins B; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL