title: Sclerotherapy of branchial cleft cysts using OK-432.
abstract: OBJECTIVE
  OK-432 has been widely used to treat lymphangioma and ranula; however, there are few studies for its use in treatment of branchial cleft cyst (BCC). We conducted this study to evaluate the effectiveness of sclerotherapy using OK-432 in treatment of BCC.
  
  
  METHODS
  Case series with planned data collection.
  
  
  METHODS
  From 2004 to 2007, we treated 23 patients with BCC using OK-432 sclerotherapy. Of these 23 patients, 18 had unilocular cysts and five had multilocular cysts. The sizes of the BCCs were measured and compared before and after treatment.
  
  
  RESULTS
  Of the 23 cases, 14 (60.8%) showed complete regression; all of these were unilocular cysts. Of the remaining individuals with unilocular cysts, only one patient failed to show any response. This individual subsequently underwent surgical excision. A total of five patients with multilocular cysts showed no or partial response and subsequently underwent surgical excision. Minor adverse effects including fever and local pain were reported by 13 (56.5%) patients.
  
  
  CONCLUSIONS
  These results suggest that sclerotherapy using OK-432 is an effective and safe treatment modality for BCC, especially for unilocular cysts. Sclerosing of unilocular BCC with OK-432 should therefore be considered before surgical excision.
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Masan Samsung Hospital, Seoul, Korea.
authors.forename: Myung-Gu
authors.initials: MG
authors.lastname: Kim
authors.forename: No-Hee
authors.initials: NH
authors.lastname: Lee
authors.forename: Jae-Ho
authors.initials: JH
authors.lastname: Ban
authors.forename: Kyung-Chul
authors.initials: KC
authors.lastname: Lee
authors.forename: Sung-Min
authors.initials: SM
authors.lastname: Jin
authors.forename: Sang-Hyuk
authors.initials: SH
authors.lastname: Lee
mesh_terms: D000293:Adolescent; D000328:Adult; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D044963:Biopsy, Fine-Needle; D001935:Branchioma / Q000175:diagnosis / Q000628:therapy*; D003937:Diagnosis, Differential; D004305:Dose-Response Relationship, Drug; D005260:Female; D005500:Follow-Up Studies; D006258:Head and Neck Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D007272:Injections, Intralymphatic; D008297:Male; D008875:Middle Aged; D010844:Picibanil / Q000008:administration & dosage / Q000627:therapeutic use*; D011446:Prospective Studies; D015911:Sclerotherapy / Q000379:methods*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents; D010844:Picibanil