title: Effect of strontium-containing hydroxyapatite bone cement  on bone remodeling following hip replacement.
abstract: It is uncertain whether the use of bioactive bone cement has any beneficial effect on local bone adaptation following hip replacement. In this study, twelve goats underwent cemented hip hemiarthroplasty unilaterally, with either PMMA bone cement or strontium-containing hydroxyapatite (Sr-HA) bioactive bone cement. Nine months later, the femoral cortical bones at different levels were analyzed by microhardness testing and micro-CT scanning. Extensive bone remodeling was found at proximal and mid-levels in both PMMA and Sr-HA groups. However, with regard to the differences of bone mineral density, cortical bone area and bone hardness between implanted and non-implanted femur, less decreases were found in Sr-HA group than PMMA group at proximal and mid-levels, and significant differences were shown for bone area and hardness at proximal level. The results suggested that the use of Sr-HA cement might alleviate femoral bone remodeling after hip replacement.
authors.affiliation: Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515 China. fgxni@graduate.hku.hk [corrected]
authors.forename: Guo X
authors.initials: GX
authors.lastname: Ni
authors.forename: Jian H
authors.initials: JH
authors.lastname: Lin
authors.forename: Peter K Y
authors.initials: PK
authors.lastname: Chiu
authors.forename: Zhao Y
authors.initials: ZY
authors.lastname: Li
authors.forename: William W
authors.initials: WW
authors.lastname: Lu
mesh_terms: D000818:Animals; D019644:Arthroplasty, Replacement, Hip / Q000534:rehabilitation*; D001672:Biocompatible Materials / Q000737:chemistry / Q000494:pharmacology; D001843:Bone Cements / Q000737:chemistry / Q000494:pharmacology*; D015519:Bone Density; D016723:Bone Remodeling / Q000187:drug effects*; D002484:Cementation / Q000379:methods; D017886:Durapatite / Q000737:chemistry / Q000494:pharmacology*; D006041:Goats; D006245:Hardness Tests; D006622:Hip Prosthesis; D008954:Models, Biological; D019904:Polymethyl Methacrylate / Q000494:pharmacology; D011182:Postoperative Care / Q000295:instrumentation / Q000379:methods*; D011897:Random Allocation; D013314:Stress, Mechanical; D055114:X-Ray Microtomography
chemical_list: D001672:Biocompatible Materials; D001843:Bone Cements; C509320:strontium-containing hydroxyapatite; D019904:Polymethyl Methacrylate; D017886:Durapatite