title: Administration of high-dose interleukin-2 in a 2-year-old with metastatic melanoma.
abstract: Malignant melanoma is rare in pediatrics, and therapies for patients with disseminated disease have not been well studied. This report describes our experience with the use of high-dose interleukin 2 (aldesleukin, IL-2) in a 2-year-old child with metastatic melanoma and describes our approach for the administration of this agent to young patients.
authors.affiliation: Department of Pharmacy, Texas Children's Hospital, Houston, Texas 77030, USA. mbbernha@texaschildrens.org
authors.forename: M Brooke
authors.initials: MB
authors.lastname: Bernhardt
authors.forename: M John
authors.initials: MJ
authors.lastname: Hicks
authors.forename: Alberto S
authors.initials: AS
authors.lastname: Pappo
mesh_terms: D000700:Analgesics / Q000008:administration & dosage / Q000627:therapeutic use; D000740:Anemia / Q000139:chemically induced; D000930:Antidiarrheals / Q000008:administration & dosage / Q000627:therapeutic use; D000932:Antiemetics / Q000008:administration & dosage / Q000627:therapeutic use; D002637:Chest Pain / Q000139:chemically induced; D003131:Combined Modality Therapy; D017809:Fatal Outcome; D005260:Female; D005440:Fluid Therapy; D006801:Humans; D007022:Hypotension / Q000139:chemically induced; D007155:Immunologic Factors / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D007223:Infant; D007262:Infusions, Intravenous; D007372:Interferons / Q000627:therapeutic use*; D007376:Interleukin-2 / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D008545:Melanoma / Q000188:drug therapy / Q000556:secondary* / Q000601:surgery; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy*; D011292:Premedication; D011654:Pulmonary Edema / Q000139:chemically induced; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000601:surgery
chemical_list: D000700:Analgesics; D000930:Antidiarrheals; D000932:Antiemetics; D007155:Immunologic Factors; D007376:Interleukin-2; D007372:Interferons