The preliminary assessment of chlorhexidine and lidocaine release from preparations of anionic polymer, evaluated by the conductivity measurements.
The aim of this work was the evaluation of conductivity assessments for the monitoring and controlling the release study process of chlorhexidine and lidocaine hydrochloride from the ionic polyacrylic gel, applying different temperatures. According to performed measurements of release, the chlorhexidine, characterized by very low water solubility, is observed in the acceptor compartment in the amount of 2.0-3.0% and its level depends of the temperature. The amount of well soluble lidocaine hydrochloride released in parallel conditions was between 60 and 70%. Beyond, the assessments confirm the presence of a specific bond between the chlorhexidine imine groups and polyacrylic acid carboxylic groups. Presented method may be applied in the prediction of release rates, before actual release analysis, and may assure better evaluation of the systems.
Musial
Witold
W
Department for Textile Materials and Design University of Maribor, Slovenia. witold@ktpl.am.wroc.pl
Kokol
Vanja
V
Voncina
Bojana
B
D000180:Acrylic Resins / Q000737:chemistry; D000838:Anions / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D002710:Chlorhexidine / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D005782:Gels / Q000737:chemistry; D008012:Lidocaine / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D012995:Solubility; D013696:Temperature
D000180:Acrylic Resins; D000838:Anions; D004337:Drug Carriers; D005782:Gels; D011108:Polymers; C006903:carbopol 940; D008012:Lidocaine; D002710:Chlorhexidine