title: Solvent free synthesis of 1,5-disubstituted tetrazoles derived from Baylis Hillman acetates as potential TNF-alpha inhibitors.
abstract: Solvent free multicomponent reaction of Baylis Hillman acetate, TMS azide and arylnitrile to produce 1,5-disubstituted tetrazole is described. Some of these tetrazoles are found to be potential TNF-alpha inhibitors.
authors.affiliation: Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad 500 607, India. srihari@iict.res.in
authors.forename: P
authors.initials: P
authors.lastname: Srihari
authors.forename: Palash
authors.initials: P
authors.lastname: Dutta
authors.forename: R Srinivasa
authors.initials: RS
authors.lastname: Rao
authors.forename: J S
authors.initials: JS
authors.lastname: Yadav
authors.forename: S
authors.initials: S
authors.lastname: Chandrasekhar
authors.forename: P
authors.initials: P
authors.lastname: Thombare
authors.forename: J
authors.initials: J
authors.lastname: Mohapatra
authors.forename: A
authors.initials: A
authors.lastname: Chatterjee
authors.forename: Mukul R
authors.initials: MR
authors.lastname: Jain
mesh_terms: D000085:Acetates / Q000737:chemistry*; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D012997:Solvents / Q000737:chemistry; D013777:Tetrazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D000085:Acetates; D000893:Anti-Inflammatory Agents; D012997:Solvents; D013777:Tetrazoles; D014409:Tumor Necrosis Factor-alpha