title: Recipient-derived chronic lymphocytic leukaemia diagnosed shortly after kidney transplantation on protocol biopsy.
abstract: Here we present the case of a patient with diagnosis of chronic lymphocytic leukaemia (CLL) on routine protocol biopsy 3 months following kidney transplantation. Genetic analysis confirmed the origin of the malignancy, being the recipient. Differential diagnosis with post-transplant lymphoproliferative disorder (PTLD) is extremely important in order to avoid unnecessary devastating treatment. This case is challenging, both in terms of making the correct diagnosis and in terms of optimal treatment. The case underscores that it is extremely important to distinguish between a pre-existing lymphoma diagnosis after transplantation and a true PTLD as the treatment options of both are very divergent.
authors.affiliation: Department of Hematology, University Hospitals Gasthuisberg, Leuven, Belgium. Daan.dierickx@uz.kuleuven.ac.be
authors.forename: Daan
authors.initials: D
authors.lastname: Dierickx
authors.forename: Anja
authors.initials: A
authors.lastname: De Rycke
authors.forename: Peter
authors.initials: P
authors.lastname: Vandenberghe
authors.forename: Ann
authors.initials: A
authors.lastname: Janssens
authors.forename: Evelyne
authors.initials: E
authors.lastname: Lerut
authors.forename: Christiane
authors.initials: C
authors.lastname: De Wolf-Peeters
authors.forename: Gregor
authors.initials: G
authors.lastname: Verhoef
authors.forename: Pieter
authors.initials: P
authors.lastname: Evenepoel
mesh_terms: D000368:Aged; D001706:Biopsy; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000601:surgery*; D016030:Kidney Transplantation; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications* / Q000473:pathology*; D008297:Male; D011184:Postoperative Period