title: Uncomplicated peptic ulcer in the UK: trends from 1997 to 2005.
abstract: BACKGROUND
  Few studies have examined the incidence of uncomplicated peptic ulcer or the trends in factors affecting its incidence.
  
  
  OBJECTIVE
  To estimate the incidence rate of uncomplicated peptic ulcer in the UK from 1997 to 2005 and report temporal changes in the main known preventive and risk factors.
  
  
  METHODS
  Population-based cohort study of 1 049 689 patients enrolled in The Health Improvement Network in the UK. We estimated the incidence rate of uncomplicated peptic ulcer and evaluated temporal trends in demographic characteristics and prescription patterns for various anti-inflammatory and gastroprotective agents.
  
  
  RESULTS
  Overall uncomplicated peptic ulcer incidence was 0.75 cases per 1000 persons-years, declining from 1.1 to 0.52 cases per 1000 person-years between 1997 and 2005. Distributions of age, gender and alcohol habits were similar in 1997 and 2005. The proportion of documented Helicobacter pylori-negative cases increased from 5% to 12%. Monthly prevalence of subjects with prescriptions for traditional non-aspirin NSAIDs changed from 7.7% to 6.8%, Coxibs from 0% to 0.7%, and proton pump inhibitors (PPIs) from 2.4% to 7.4%. The proportion of subjects on prescription NSAIDs on PPIs increased continuously over time.
  
  
  CONCLUSIONS
  A reduction in H. pylori-related peptic ulcers, changing patterns in NSAID use and increasing PPI use may have contributed to a decline in uncomplicated peptic ulcer incidence in the UK.
authors.affiliation: Epidemiology Department, Harvard School of Public Health, Boston, MA 02115, USA. scai@hsph.harvard.edu
authors.forename: S
authors.initials: S
authors.lastname: Cai
authors.forename: L A
authors.initials: LA
authors.lastname: García Rodríguez
authors.forename: E L
authors.initials: EL
authors.lastname: Massó-González
authors.forename: S
authors.initials: S
authors.lastname: Hernández-Díaz
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D011307:Drug Prescriptions / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D050177:Overweight; D010437:Peptic Ulcer / Q000175:diagnosis / Q000453:epidemiology* / Q000517:prevention & control; D012307:Risk Factors; D012737:Sex Factors; D012907:Smoking / Q000639:trends; D006113:United Kingdom / Q000453:epidemiology