title: A multi-institutional acute gastrointestinal toxicity analysis of anal cancer patients treated with concurrent intensity-modulated radiation therapy (IMRT) and chemotherapy.
abstract: Using previous dosimetric analysis methods, we identified the volume of bowel receiving 30 Gy (V(30)) correlated with acute gastrointestinal (GI) toxicity in anal cancer patients treated with intensity-modulated radiation therapy and concurrent chemotherapy. For V(30)>450 cc and < or =450 cc, acute GI toxicity was 33% and 8%, respectively (p=0.003).
authors.affiliation: Department of Radiation and Cellular Oncology, University of Chicago, IL, USA.
authors.forename: Kiran
authors.initials: K
authors.lastname: Devisetty
authors.forename: Loren K
authors.initials: LK
authors.lastname: Mell
authors.forename: Joseph K
authors.initials: JK
authors.lastname: Salama
authors.forename: David A
authors.initials: DA
authors.lastname: Schomas
authors.forename: Robert C
authors.initials: RC
authors.lastname: Miller
authors.forename: Ashesh B
authors.initials: AB
authors.lastname: Jani
authors.forename: John C
authors.initials: JC
authors.lastname: Roeske
authors.forename: Bulent
authors.initials: B
authors.lastname: Aydogan
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Chmura
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001005:Anus Neoplasms / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D041981:Gastrointestinal Tract / Q000187:drug effects* / Q000528:radiation effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage; D050397:Radiotherapy, Intensity-Modulated / Q000009:adverse effects*
chemical_list: D016685:Mitomycin; D005472:Fluorouracil