title: Action of plant proteinase inhibitors on enzymes of physiopathological importance.
abstract: Obtained from leguminous seeds, various plant proteins inhibit animal proteinases, including human, and can be considered for the development of compounds with biological activity. Inhibitors from the Bowman-Birk and plant Kunitz-type family have been characterized by proteinase specificity, primary structure and reactive site. Our group mostly studies the genus Bauhinia, mainly the species bauhinioides, rufa, ungulata and variegata. In some species, more than one inhibitor was characterized, exhibiting different properties. Although proteins from this group share high structural similarity, they present differences in proteinase inhibition, explored in studies using diverse biological models.
authors.affiliation: Departamento de Bioquímica, Universidade Federal de São Paulo, Escola Paulista de Medicina, Rua Três de Maio, 100, 04044-020 São Paulo, SP, Brasil. olivaml.bioq@epm.br
authors.forename: Maria Luiza V
authors.initials: ML
authors.lastname: Oliva
authors.forename: Misako U
authors.initials: MU
authors.lastname: Sampaio
mesh_terms: D000818:Animals; D002918:Chymotrypsin / Q000037:antagonists & inhibitors; D007887:Fabaceae / Q000737:chemistry* / Q000145:classification; D006801:Humans; D010455:Peptides / Q000302:isolation & purification / Q000494:pharmacology; D010940:Plant Proteins / Q000302:isolation & purification / Q000494:pharmacology; D020842:Plasma Kallikrein / Q000037:antagonists & inhibitors; D011480:Protease Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D012639:Seeds / Q000737:chemistry / Q000145:classification; D014358:Trypsin Inhibitor, Bowman-Birk Soybean / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: C053865:Kunitz-type protease inhibitor, plant; D010455:Peptides; D010940:Plant Proteins; D011480:Protease Inhibitors; D014358:Trypsin Inhibitor, Bowman-Birk Soybean; D002918:Chymotrypsin; D020842:Plasma Kallikrein