Efficacy of oral administration of a heat-killed Lactobacillus gasseri OLL2809 on patients of Japanese cedar pollinosis with high Japanese-cedar pollen-specific IgE.
A randomized, double-blind, placebo-controlled clinical trial was conducted to determine whether oral administration of heat-killed Lactobacillus gasseri OLL2809 would affect the immune response and reduce the symptoms of Japanese cedar pollinosis (JCP) in subjects with JCP. Following a 1-week pre-observation period, the subjects were randomly divided into two groups and were orally administered a placebo or tablets containing 100 mg of L. gasseri OLL2809 per d for 8 weeks during the pollen season in 2007. The results showed no obvious differences between the groups. Supplementary subgroup analysis revealed that the OLL2809 subgroups with CAP-RAST scores of 4 or 5 exhibited improvement in nasal symptoms scores and serum allergy-related items, including Japanese cedar pollen-specific IgE levels. L. gasseri OLL2809 was found to be effective in reducing symptoms in subjects with a high predisposition to allergies by modulating systemic immune systems.
Gotoh
Minoru
M
Department of Otorhinolaryngology, Nippon Medical School Chiba Hokusoh Hospital, 1715 Kamakari, Inba-mura, Inba-gun, Chiba 270-1694, Japan. m.gotoh@nms.ac.jp
Sashihara
Toshihiro
T
Ikegami
Shuji
S
Yamaji
Taketo
T
Kino
Kohsuke
K
Orii
Naoki
N
Taketomo
Naoki
N
Okubo
Kimihiro
K
D000284:Administration, Oral; D032485:Cryptomeria / Q000276:immunology*; D004311:Double-Blind Method; D006358:Hot Temperature; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology*; D007778:Lactobacillus; D010919:Placebos; D011058:Pollen / Q000276:immunology*; D006255:Rhinitis, Allergic, Seasonal / Q000276:immunology / Q000628:therapy*
D010919:Placebos; D007073:Immunoglobulin E