Efficacy of a new formulation of amphotericin B in murine disseminated infections by Candida glabrata or Candida tropicalis.
Amphotericin B microspheres (M-AMB) are a new, inexpensive formulation of amphotericin B. In this study, we tested the efficacy of this new formulation for treating murine disseminated infections by Candida glabrata or Candida tropicalis. M-AMB showed a similar efficacy to that of amphotericin B deoxycholate and liposomal amphotericin B in the treatment of both disseminated murine infections. Its low toxicity and inexpensive production costs make this formulation potentially attractive for the treatment of fungal infections.
Mariné
Marçal
M
Unitat de Microbiologia, Facultat de Medicina, IISPV, Universitat Rovira i Virgili, Carrer Sant Llorenç 21, 43201, Reus, Spain.
Espada
Raquel
R
Torrado
Juan
J
Pastor
F Javier
FJ
Guarro
Josep
J
D000666:Amphotericin B / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use*; D000818:Animals; D000935:Antifungal Agents / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use*; D041221:Candida glabrata / Q000187:drug effects*; D041022:Candida tropicalis / Q000187:drug effects*; D002177:Candidiasis / Q000188:drug therapy* / Q000382:microbiology; D002626:Chemistry, Pharmaceutical; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008863:Microspheres; D016019:Survival Analysis; D016896:Treatment Outcome
D000935:Antifungal Agents; D000666:Amphotericin B