[Effects of telmisartan on voltage-gated Kv1.3 and Kv1.5 potassium channels expressed in Xenopus oocytes].
OBJECTIVE
To observe the effects of telmisartan on Kv1.3 and Kv1.5 potassium channels expressed in Xenopus oocytes.


METHODS
Kv1.3 and Kv1.5 potassium channel currents expressed in Xenopus oocytes were recorded and observed in the absence and presence of telmisartan using standard two-microelectrode voltage clamp techniques.


RESULTS
Telmisartan resulted in a concentration- and voltage-dependent inhibition effect on Kv1.3 channel current (IC(50) 2.05 micromol/L)and on Kv1.5 channel current (IC(50) 2.37 micromol/L).


CONCLUSIONS
Telmisartan blocks open-state Kv1.3 channel which could be one of the mechanisms related to its immunomodulatory and anti-atherosclerosis effect. Telmisartan also blocks open-state Kv1.5 channel which might partly account for its effect on reducing the incidence of atrial fibrillation.
Li
Mu-Wei
MW
Department of Cardiology, Henan Provincial People's Hospital, Zhengzhou 450003, China.
Wang
Xian-Pei
XP
Gao
Chuan-Yu
CY
Zou
An-Ruo
AR
D000818:Animals; D001562:Benzimidazoles / Q000494:pharmacology*; D001565:Benzoates / Q000494:pharmacology*; D066298:In Vitro Techniques; D051664:Kv1.3 Potassium Channel / Q000187:drug effects*; D051666:Kv1.5 Potassium Channel / Q000187:drug effects*; D009865:Oocytes / Q000187:drug effects* / Q000378:metabolism; D018408:Patch-Clamp Techniques; D000077333:Telmisartan; D014981:Xenopus
D001562:Benzimidazoles; D001565:Benzoates; D051664:Kv1.3 Potassium Channel; D051666:Kv1.5 Potassium Channel; D000077333:Telmisartan