title: IL-6 and IL-8 levels in GCF of the teeth supporting fixed partial denture.
abstract: OBJECTIVE
  To evaluate the gingival crevicular fluid (GCF) contents of interleukin-6 (IL-6) and interleukin-8 (IL-8) and the clinical parameters of the teeth supporting fixed partial denture (FPD) and the contralateral teeth and to assess the effect of scaling and root planning (SRP) on clinical parameters and the GCF levels of cytokines.
  
  
  METHODS
  The study population included 23 patients. Probing depth (PD), clinical attachment level (CAL), plaque index (PI), and gingival index (GI) were recorded, and GCF samples were collected for analysis of cytokine levels from the teeth with FPD (Test Group), the contralateral teeth (Control Group) of each participant at baseline. After initial measurements, all participants received primary phase of non-surgical treatment including oral hygiene instruction and scaling and root planning (SRP). At the 1st month and the 3rd month after SRP, these procedures were repeated.
  
  
  RESULTS
  In both groups, all clinical parameters and the total amount of IL-8 showed decreases from initial to the 3rd month (P < 0.05), but from the 1st month to the 3rd month; PD, PI, and GI values significantly increased in the test group (P < 0.05).
  
  
  CONCLUSIONS
  The non-surgical periodontal treatment reduced the total amount of IL-8, not IL-6, and the clinical parameters of the teeth with FPD and contralateral teeth. But, there was a trend to the higher levels of PD, PI, and GI in the teeth with FPD. Therefore, a regular program for dental prophylaxis is also important for the maintenance of periodontal health in patients with FPD.
authors.affiliation: Department of Periodontology, Faculty of Dentistry, Kirikkale University, Kirikkale, Turkey. olgun_ebru@yahoo.com
authors.forename: E O
authors.initials: EO
authors.lastname: Erdemir
authors.forename: I
authors.initials: I
authors.lastname: Baran
authors.forename: R
authors.initials: R
authors.lastname: Nalcaci
authors.forename: T
authors.initials: T
authors.lastname: Apan
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D055113:Chronic Periodontitis / Q000276:immunology / Q000628:therapy; D000044:Dental Abutments; D003773:Dental Plaque / Q000276:immunology / Q000628:therapy; D012534:Dental Scaling; D003830:Denture, Partial, Fixed / Q000009:adverse effects; D005260:Female; D005883:Gingival Crevicular Fluid / Q000276:immunology*; D005891:Gingivitis / Q000276:immunology* / Q000628:therapy; D006801:Humans; D015850:Interleukin-6 / Q000032:analysis / Q000276:immunology*; D016209:Interleukin-8 / Q000032:analysis / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D018709:Statistics, Nonparametric
chemical_list: D015850:Interleukin-6; D016209:Interleukin-8