Factors that predict duration of delayed graft function in cadaveric kidney transplantation.
BACKGROUND
We have previously shown that the duration of delayed graft function (DGF) is a significant predictor of serum creatinine concentration at 1 year posttransplantation, which may be a surrogate marker for kidney survival after renal transplantation.


OBJECTIVE
To identify donor and recipient characteristics that influence the duration of DGF in a 2-center study.


METHODS
This retrospective analysis of 212 consecutive cadaveric renal transplant procedures examined the following variables: donor and recipient age and sex, cause of death (cerebrovascular accident or trauma), donor creatinine and sodium concentrations, multiorgan or kidney-only donor use, type of vasoactive drugs, cold ischemia time, percent reactive antibodies, and HLA mismatch.


RESULTS
Overall, 30.5% of recipients experienced DGF with a mean (SD) duration of 4.4 (8) days. At univariate analysis, the use of norepinephrine in the donor and increased cold ischemia time were associated with longer DGF duration. However, at multivariate analysis, none of the factors studied was significant.


CONCLUSIONS
The duration of DGF may be associated with longer cold ischemia time, which emphasizes the need to shorten this period insofar as possible to improve long-term results. The association of use of norepinephrine and prolonged DGF should be observed carefully because it may be that use of this drug is related to worse hemodynamics in the donor and not to deleterious effects of the drug per se.
Domínguez
J
J
Department of Urology, Pontifical Catholic University of Chile, Santiago, Chile. javierdomi@hotmail.com
Lira
F
F
Troncoso
P
P
Aravena
C
C
Ortiz
M
M
Gonzalez
R
R
D000328:Adult; D002102:Cadaver; D002423:Cause of Death; D003404:Creatinine / Q000097:blood; D051799:Delayed Graft Function / Q000097:blood / Q000453:epidemiology* / Q000276:immunology; D005260:Female; D006085:Graft Survival / Q000276:immunology / Q000502:physiology*; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology* / Q000401:mortality / Q000502:physiology; D008297:Male; D015337:Multicenter Studies as Topic; D012189:Retrospective Studies; D015996:Survival Rate; D014019:Tissue Donors
D003404:Creatinine