title: Luteinizing hormone increases platelet-derived growth factor-D gene expression in human granulosa-luteal cells.
abstract: We aimed to investigate the effects of LH and FSH on the gene expression of the platelet-derived growth factor (PDGF) gene family in human granulosa-luteal cells. We found that LH significantly increased PDGF-D messenger RNA (mRNA) expression but suppressed PDGF-B and PDGF-C mRNA in human granulosa-luteal cells, and FSH also increases PDGF-D gene expression, but to a lesser extent.
authors.affiliation: Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei, Taiwan.
authors.forename: Yuh-Ming
authors.initials: YM
authors.lastname: Hwu
authors.forename: Sheng-Hsiang
authors.initials: SH
authors.lastname: Li
authors.forename: Robert Kuo-kuang
authors.initials: RK
authors.lastname: Lee
authors.forename: Ming-Huei
authors.initials: MH
authors.lastname: Lin
authors.forename: Yu-Hui
authors.initials: YH
authors.lastname: Tsai
authors.forename: Tien-Shun
authors.initials: TS
authors.lastname: Yeh
mesh_terms: D002478:Cells, Cultured; D003338:Corpus Luteum / Q000166:cytology*; D005260:Female; D015870:Gene Expression / Q000187:drug effects; D006107:Granulosa Cells / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D007986:Luteinizing Hormone / Q000378:metabolism* / Q000494:pharmacology; D008222:Lymphokines / Q000235:genetics*; D006080:Ovarian Follicle / Q000166:cytology; D010982:Platelet-Derived Growth Factor / Q000235:genetics*; D020574:Proto-Oncogene Proteins c-sis / Q000235:genetics; D012333:RNA, Messenger / Q000378:metabolism
chemical_list: D008222:Lymphokines; C427493:PDGFD protein, human; D010982:Platelet-Derived Growth Factor; D020574:Proto-Oncogene Proteins c-sis; D012333:RNA, Messenger; C411423:platelet-derived growth factor C; D007986:Luteinizing Hormone