title: Dendrimers in solution can have their remote catalytic groups folded back into the core: enantioselective transaminations by dendritic enzyme mimics-II.
abstract: PAMAM dendrimers with double thioether arms have been synthesized with a pyridoxamine core and terminal chiral amino groups. Transamination to afford natural isomers of phenylalanine and alanine induced enantioselectivity by the peripheral chiral caps, supporting a computer model that indicates folding of dendrimer chains back into the core.
authors.affiliation: Columbia University, Department of Chemistry, 3000 Broadway, New York, NY 10027, USA.
authors.forename: Sujun
authors.initials: S
authors.lastname: Wei
authors.forename: Jianing
authors.initials: J
authors.lastname: Wang
authors.forename: Scott
authors.initials: S
authors.lastname: Venhuizen
authors.forename: Rachid
authors.initials: R
authors.lastname: Skouta
authors.forename: Ronald
authors.initials: R
authors.lastname: Breslow
mesh_terms: D000586:Amination; D002384:Catalysis; D050091:Dendrimers; D004798:Enzymes / Q000737:chemistry / Q000378:metabolism; D008968:Molecular Conformation; D011073:Polyamines / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D011733:Pyridoxamine / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D050091:Dendrimers; D004798:Enzymes; C104700:PAMAM Starburst; D011073:Polyamines; D011733:Pyridoxamine