title: Differentiation and apoptosis in UVA-irradiated cells treated with furocoumarin derivatives.
abstract: In this review we summarize the structure and biological effects of linear and angular psoralens. These compounds exhibit interesting biological effects on the cell cycle, apoptosis and differentiation. These molecules should be considered promising drugs in the therapy of several diseases, including psoriasis, mycosis fungoides and cancer. Also, preclinical data demonstrate a possible use of these molecules for the treatment of beta-thalassemia and other hematological disorders.
authors.affiliation: Department of Pharmaceutical Sciences, University of Padova, Padova, Italy.
authors.forename: Giampietro
authors.initials: G
authors.lastname: Viola
authors.forename: Alessia
authors.initials: A
authors.lastname: Salvador
authors.forename: Daniela
authors.initials: D
authors.lastname: Vedaldi
authors.forename: Francesco
authors.initials: F
authors.lastname: Dall'Acqua
authors.forename: Nicoletta
authors.initials: N
authors.lastname: Bianchi
authors.forename: Cristina
authors.initials: C
authors.lastname: Zuccato
authors.forename: Monica
authors.initials: M
authors.lastname: Borgatti
authors.forename: Ilaria
authors.initials: I
authors.lastname: Lampronti
authors.forename: Roberto
authors.initials: R
authors.lastname: Gambari
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects* / Q000528:radiation effects; D002453:Cell Cycle / Q000187:drug effects; D002454:Cell Differentiation / Q000187:drug effects* / Q000528:radiation effects; D005363:Ficusin / Q000737:chemistry / Q000494:pharmacology*; D011564:Furocoumarins / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D011701:PUVA Therapy / Q000379:methods; D014466:Ultraviolet Rays
chemical_list: D011564:Furocoumarins; C011659:angelicin; D005363:Ficusin