title: ATP synthase inhibition of Mycobacterium avium is not bactericidal.
abstract: The efficacy of ATP synthase inhibitor TMC207 was assessed in early and late Mycobacterium avium infections in mice. In contrast to what was earlier observed for M. tuberculosis, a bacteriostatic effect was obtained. In vitro, the minimal bactericidal concentration (MBC)/MIC ratio was very high. The MBC was more relevant for assessment of pharmacokinetic/pharmacodynamic relationships than the MIC.
authors.affiliation: Department of Antimicrobial Research, Tibotec BVBA, Johnson & Johnson, Turnhoutseweg 30, 2340 Beerse, Belgium.
authors.forename: Nacer
authors.initials: N
authors.lastname: Lounis
authors.forename: Tom
authors.initials: T
authors.lastname: Gevers
authors.forename: Joke
authors.initials: J
authors.lastname: Van den Berg
authors.forename: Luc
authors.initials: L
authors.lastname: Vranckx
authors.forename: Koen
authors.initials: K
authors.lastname: Andries
mesh_terms: D000818:Animals; D000995:Antitubercular Agents / Q000494:pharmacology*; D064687:Diarylquinolines; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005260:Female; D051379:Mice; D008810:Mice, Inbred C57BL; D008826:Microbial Sensitivity Tests; D009162:Mycobacterium avium / Q000187:drug effects*; D011804:Quinolines / Q000493:pharmacokinetics / Q000494:pharmacology*
chemical_list: D000995:Antitubercular Agents; D064687:Diarylquinolines; D004791:Enzyme Inhibitors; D011804:Quinolines; C493870:bedaquiline