Body weight change in women receiving adjuvant chemotherapy for breast cancer: a French prospective study.
OBJECTIVE
Adjuvant chemotherapy has frequently been associated with weight gain after breast cancer diagnosis. We aimed to prospectively evaluate body weight variations in French patients with early breast cancer.


METHODS
This prospective observational study included 272 breast cancer patients who were candidates for adjuvant chemotherapy. Weight and body mass index were measured at baseline visit, then at 9 and 15 months from baseline (6 and 12-month post-chemotherapy). At baseline visit, information on the benefits of weight gain prevention and healthy diet was given by a dietician. Univariate logistic regression was performed to test the association between weight gain and potential predictive factors.


RESULTS
Thirty percent of patients gained weight during the year before diagnosis, 26% were overweight and 15% were obese. At one year, the mean weight change was +1.5kg (SD=4.1) and +2.3% (SD=6.0); 60% of the cohort had gained weight, with a median increase of 3.9kg (SD=3.0) and 5.9% (SD=4.4). Reported weight gain during the year before diagnosis appears to be the only factor associated with the absence of post-chemotherapy weight gain (OR=0.54, 95% CI [0.31-0.95], p=0.034).


CONCLUSIONS
Body weight increased in the post-chemotherapy period in French breast cancer survivors, even when given dietary recommendations. Appropriate weight management interventions with nutritional follow-up and physical activity programs are needed.
Trédan
Olivier
O
Université de Lyon - Centre Léon Bérard, Department of Medical Oncology, 28 rue Laennec, 69008 Lyon, France.
Bajard
Agathe
A
Meunier
Anne
A
Roux
Pascale
P
Fiorletta
Ingrid
I
Gargi
Thérèse
T
Bachelot
Thomas
T
Guastalla
Jean-Paul
JP
Lallemand
Yolande
Y
Faure
Christelle
C
Pérol
David
D
Bachmann
Patrick
P
D000328:Adult; D000368:Aged; D000375:Aging; D000886:Anthropometry; D015992:Body Mass Index; D001835:Body Weight / Q000187:drug effects; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D002277:Carcinoma / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D015331:Cohort Studies; D004032:Diet; D055088:Early Detection of Cancer; D005260:Female; D005500:Follow-Up Studies; D005602:France; D006801:Humans; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D010353:Patient Education as Topic; D017698:Postmenopause; D017697:Premenopause; D011446:Prospective Studies; D013997:Time Factors; D055815:Young Adult