title: Population structure dynamics of Mycobacterium tuberculosis Beijing strains during past decades in Japan.
abstract: We used 909 strains to compare the population structures of the Mycobacterium tuberculosis Beijing family between different birth-year cohorts in Japan. The results revealed that the spread of a modern sublineage that has high transmissibility is currently increasing, while the spread of an ancient sublineage, STK, has significantly decreased in younger generations.
authors.affiliation: Department of Microbiology, Kobe Institute of Health, Kobe, Japan. kx2t-iwmt@asahi-net.or.jp
authors.forename: Tomotada
authors.initials: T
authors.lastname: Iwamoto
authors.forename: Riyo
authors.initials: R
authors.lastname: Fujiyama
authors.forename: Shiomi
authors.initials: S
authors.lastname: Yoshida
authors.forename: Takayuki
authors.initials: T
authors.lastname: Wada
authors.forename: Chika
authors.initials: C
authors.lastname: Shirai
authors.forename: Yasuto
authors.initials: Y
authors.lastname: Kawakami
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015373:Bacterial Typing Techniques; D005260:Female; D005838:Genotype; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D017720:Molecular Epidemiology; D009169:Mycobacterium tuberculosis / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D014376:Tuberculosis / Q000453:epidemiology* / Q000382:microbiology* / Q000635:transmission