[Clinical significance of anticoagulant proteins detection in patients with thrombotic events].
OBJECTIVE
To investigate the prevalence and the risk of natural anticoagulants such as plasma protein C (PC), protein S (PS) and antithrombin (AT) deficiency in thromboembolic patients with no evident acquired factors.


METHODS
Clotting assays on French STAGO autoanalyzer were used to detect the activity of plasma PC, PS and AT in 85 patients with thrombotic disease and 50 sex and age matched healthy controls.


RESULTS
Among the 85 enrolled patients (18 arterial and 67 venous thromboembolism), male to female ratio was 1.4 and the median age was 42 years (17-69). The activity of plasma PC, PS and AT in the pre-therapy thrombotic disease group, the thrombo-recurrence group, and the age < or = 45 years group were significantly lower than that is the healthy control group, the first thrombotic episodes group and the age > 45 years group respectively (P < 0.001, P < 0.01, P < 0.01). The overall deficiency rate of these three natural anticoagulants was 30.6%, PS deficiency was the commonest (10.6%), the second was PC deficiency (8.2%), AT deficiency and combined deficiency each accounted for 5.9%.


CONCLUSIONS
The PC, PS and AT protein deficiencies are frequent in Chinese thromboembolic patients, they are the independent risk factors for the thrombotic events and recurrence.
Zheng
Chang-Cheng
CC
Department of Hematology, Anhui Provincial Hospital, Anhui Medical University, Hefei 230001, China.
Wu
Jing-Sheng
JS
Ding
Kai-Yang
KY
Li
Jie
J
Hu
He-Jie
HJ
Ding
Xiao-Ling
XL
Liu
Xin
X
Cai
Xiao-Yan
XY
Zhu
Wei-Bo
WB
D000293:Adolescent; D000328:Adult; D000368:Aged; D000991:Antithrombins / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011486:Protein C / Q000378:metabolism*; D020151:Protein C Deficiency / Q000097:blood; D017293:Protein S / Q000378:metabolism*; D018455:Protein S Deficiency / Q000097:blood; D012307:Risk Factors; D013927:Thrombosis / Q000097:blood* / Q000209:etiology; D055815:Young Adult
D000991:Antithrombins; D011486:Protein C; D017293:Protein S