title: When DNA replication and protein synthesis come together.
abstract: In all organisms, DNA and protein are synthesized by dedicated, but unrelated, machineries that move along distinct templates with no apparent coordination. Therefore, connections between DNA replication and translation are a priori unexpected. However, recent findings support the existence of such connections throughout the three domains of life. In particular, we recently identified in archaeal genomes a conserved association between genes encoding DNA replication and ribosome-related proteins which all have eukaryotic homologs. We believe that this gene organization is biologically relevant and, moreover, that it suggests the existence of a mechanism coupling DNA replication and translation in Archaea and Eukarya.
authors.affiliation: Université Paris-Sud 11, CNRS UMR 8621, Institut de Génétique et Microbiologie, 91405 Orsay Cedex, France. jonathan.berthon@gmx.fr
authors.forename: Jonathan
authors.initials: J
authors.lastname: Berthon
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Fujikane
authors.forename: Patrick
authors.initials: P
authors.lastname: Forterre
mesh_terms: D000818:Animals; D001105:Archaea / Q000235:genetics* / Q000378:metabolism; D001419:Bacteria / Q000235:genetics* / Q000378:metabolism; D001426:Bacterial Proteins / Q000378:metabolism; D004261:DNA Replication / Q000235:genetics*; D020558:GTP Phosphohydrolases / Q000378:metabolism; D019204:GTP-Binding Proteins / Q000378:metabolism; D023061:Gene Order; D020745:Genome, Archaeal; D016680:Genome, Bacterial; D015894:Genome, Human; D006158:Guanosine Pentaphosphate / Q000378:metabolism; D006159:Guanosine Tetraphosphate / Q000378:metabolism; D006801:Humans; D005810:Multigene Family; D009369:Neoplasms / Q000209:etiology; D014176:Protein Biosynthesis / Q000235:genetics*
chemical_list: D001426:Bacterial Proteins; C090542:Obg GTP-binding protein, Bacteria; D006159:Guanosine Tetraphosphate; D006158:Guanosine Pentaphosphate; D020558:GTP Phosphohydrolases; D019204:GTP-Binding Proteins