Biochemical markers of joint tissue turnover.
Recent disappointments in late stage developments of anti-osteoarthritic drugs have reinforced efforts to develop better biomarkers for application in both the drug development process as well as in the routine management of these patients. Here we provide a brief review of biochemical tests available for the study of tissue turnover in each of the three compartments of the articular joint, that is the bone, the cartilage, and the synovium. Finally, we provide some perspective to future developments in biomarker discovery and discuss the potential impact such technologies could have on the drug development process.
Bay-Jensen
Anne-Christine
AC
Nordic Bioscience A/S, Herlev, Denmark.
Sondergaard
Bodil Cecilie
BC
Christiansen
Claus
C
Karsdal
Morten A
MA
Madsen
Suzi Høgh
SH
Qvist
Per
P
D015415:Biomarkers; D016723:Bone Remodeling; D002358:Cartilage, Articular / Q000378:metabolism*; D055808:Drug Discovery; D006801:Humans; D007596:Joints / Q000378:metabolism*; D010003:Osteoarthritis / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism*; D013583:Synovial Membrane / Q000378:metabolism*
D015415:Biomarkers