title: Comparative analysis of logistic regression, support vector machine and artificial neural network for the differential diagnosis of benign and malignant solid breast tumors by the use of three-dimensional power Doppler imaging.
abstract: OBJECTIVE
  Logistic regression analysis (LRA), Support Vector Machine (SVM) and a neural network (NN) are commonly used statistical models in computer-aided diagnostic (CAD) systems for breast ultrasonography (US). The aim of this study was to clarify the diagnostic ability of the use of these statistical models for future applications of CAD systems, such as three-dimensional (3D) power Doppler imaging, vascularity evaluation and the differentiation of a solid mass.
  
  
  METHODS
  A database that contained 3D power Doppler imaging pairs of non-harmonic and tissue harmonic images for 97 benign and 86 malignant solid tumors was utilized. The virtual organ computer-aided analysis-imaging program was used to analyze the stored volumes of the 183 solid breast tumors. LRA, an SVM and NN were employed in comparative analyses for the characterization of benign and malignant solid breast masses from the database.
  
  
  RESULTS
  The values of area under receiver operating characteristic (ROC) curve, referred to as Az values for the use of non-harmonic 3D power Doppler US with LRA, SVM and NN were 0.9341, 0.9185 and 0.9086, respectively. The Az values for the use of harmonic 3D power Doppler US with LRA, SVM and NN were 0.9286, 0.8979 and 0.9009, respectively. The Az values of six ROC curves for the use of LRA, SVM and NN for non-harmonic or harmonic 3D power Doppler imaging were similar.
  
  
  CONCLUSIONS
  The diagnostic performances of these three models (LRA, SVM and NN) are not different as demonstrated by ROC curve analysis. Depending on user emphasis for the use of ROC curve findings, the use of LRA appears to provide better sensitivity as compared to the other statistical models.
authors.affiliation: Department of Surgery, Changhua Christian Hospital, Changhua, Taiwan.
authors.forename: Shou-Tung
authors.initials: ST
authors.lastname: Chen
authors.forename: Yi-Hsuan
authors.initials: YH
authors.lastname: Hsiao
authors.forename: Yu-Len
authors.initials: YL
authors.lastname: Huang
authors.forename: Shou-Jen
authors.initials: SJ
authors.lastname: Kuo
authors.forename: Hsin-Shun
authors.initials: HS
authors.lastname: Tseng
authors.forename: Hwa-Koon
authors.initials: HK
authors.lastname: Wu
authors.forename: Dar-Ren
authors.initials: DR
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001185:Artificial Intelligence; D001943:Breast Neoplasms / Q000000981:diagnostic imaging*; D003936:Diagnosis, Computer-Assisted; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D021621:Imaging, Three-Dimensional / Q000706:statistics & numerical data*; D016015:Logistic Models; D008875:Middle Aged; D016571:Neural Networks, Computer; D011237:Predictive Value of Tests; D012372:ROC Curve; D012680:Sensitivity and Specificity; D018608:Ultrasonography, Doppler / Q000706:statistics & numerical data*; D016217:Ultrasonography, Mammary / Q000706:statistics & numerical data*