Pregnancy and multiple sclerosis: the initial results from a Brazilian database.
OBJECTIVE
Pregnancy management poses an extra challenge to physicians and their multiple sclerosis (MS) patients. There are few papers reporting databases on the subject.


METHODS
Brazilian database from nine MS clinical and research units, with complete data on 47 pregnant women (49 pregnancies).


RESULTS
Despite relatively high exposure to MS medications, no birth defects were reported. Low birth weight and prematurity were similar to those for developing countries. Three complications may have been associated with these medications, while three others were considered to be of purely obstetric nature.


CONCLUSIONS
Our results confirm previous findings on lower relapse rate during pregnancy and add to the present literature informing on data related to drug exposure.
Fragoso
Yara Dadalti
YD
Universidade Metropolitana de Santos, Santos, SP, Brazil. yara@bsnet.com.br
Finkelsztejn
Alessandro
A
Comini-Frota
Elizabeth Regina
ER
da Gama
Paulo Diniz
PD
Grzesiuk
Ansderson Kuntz
AK
Khouri
Jussara Mathias Netto
JM
Alves-Leon
Soniza Vieira
SV
Morales
Rogério de Rizo
Rde R
Lana-Peixoto
Marco Aurélio
MA
Rocha
Cristiane Franklin da
CF
D000328:Adult; D001938:Brazil; D016208:Databases, Factual; D005260:Female; D006801:Humans; D009103:Multiple Sclerosis / Q000188:drug therapy*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D011256:Pregnancy Outcome