title: Liver transplantation for hepatocellular carcinoma: Korean experience.
abstract: Hepatocellular carcinoma (HCC) is the second most common cause of male cancer death in Korea, where the major etiology, chronic hepatitis B virus infection, is endemic. With a high incidence of unresectable HCCs and a low cadaveric organ donation rate, the number of adult living-donor liver transplantations (LDLTs) has increased rapidly, by tenfold, over the past 10 years, as an alternative to deceased-donor liver transplantation (DDLT) in Asia, including Korea. Currently, HCC accounts for more than 40% of the indications for adult LDLT as the associated decompensation cirrhosis or unresectable HCC with 2.8% perioperative mortality at our institute. In determining eligibility for LDLT, the Milan criteria, which have a major aim of reducing the wastage of cadaveric liver grafts, still remain the gold standard. Our published results with 168 adult LDLTs show no difference from the results with DDLT for HCC that meets the Milan criteria. However, since a substantial proportion of adult LDLT patients not fulfilling the Milan criteria have been found to survive for longer than expected, and because a live donor organ is a private gift, most LDLT programs in Korea accept HCC patients beyond the Milan criteria, and the reported 3-year survival rates for such patients are approximately 63%. Our new proposal for expanded criteria (Asan criteria; tumor diameter <or=5 cm, number of lesions <or=6, no gross vascular invasion) in LDLT has focused on extending the number limits but keeping the maximum tumor size at 5 cm, because even modest expansion of tumor size limits beyond the Milan criteria adversely affected survival. The overall 5-year patient survival rates were 76.3 and only 18.9% within and beyond the Asan criteria, respectively; these criteria broaden the indications for patient selection and can more accurately identify patients who will benefit from LDLT than the conventional Milan criteria and the University of California at San Francisco criteria. In Asia, where the option for DDLT is minimal or negligible, LDLT with the modest expanded selection criteria will continue to provide a chance of long-term survival for some patients with advanced HCC.
authors.affiliation: Department of Surgery, Hepato-Biliary Surgery and Liver Transplantation, Asan Medical Center, Ulsan University, PoongNap-Dong 388-1, SongPa-Ku, Seoul, 138-736, Korea. sglee2@amc.seoul.kr
authors.forename: SungGyu
authors.initials: S
authors.lastname: Lee
authors.forename: ChulSoo
authors.initials: C
authors.lastname: Ahn
authors.forename: TaeYong
authors.initials: T
authors.lastname: Ha
authors.forename: DeokBog
authors.initials: D
authors.lastname: Moon
authors.forename: KunMoo
authors.initials: K
authors.lastname: Choi
authors.forename: GiWon
authors.initials: G
authors.lastname: Song
authors.forename: DongHwan
authors.initials: D
authors.lastname: Chung
authors.forename: GilChun
authors.initials: G
authors.lastname: Park
authors.forename: YoungDong
authors.initials: Y
authors.lastname: Yu
authors.forename: NamKyu
authors.initials: N
authors.lastname: Choi
authors.forename: KwanWoo
authors.initials: K
authors.lastname: Kim
authors.forename: KiHun
authors.initials: K
authors.lastname: Kim
authors.forename: Shin
authors.initials: S
authors.lastname: Hwang
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000453:epidemiology / Q000601:surgery*; D006801:Humans; D008113:Liver Neoplasms / Q000453:epidemiology / Q000601:surgery*; D016031:Liver Transplantation / Q000706:statistics & numerical data*; D019520:Living Donors; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D015995:Prevalence; D056910:Republic of Korea / Q000453:epidemiology; D015996:Survival Rate