[Use of guinea pigs to evaluate the efficacy of a heterological immunoglobulin against Bolivian hemorrhagic fever].
The use of guinea pigs as a laboratory model was proven to be appropriate in investigating the protective properties of a heterological immunoglobulin against Bolivian hemorrhagic fever at the preclinical stage of the study. A highly pathogenic Machupo virus strain that caused guinea pigs' death with respect with an agent's dose was cultivated. Injection of 1.0 ml of the immunoglobulin provided a 100% protective effect for the guinea pigs infected with the highly pathogenic Machupo virus strain in a dose of 10 LD50.
Khmelev
A L
AL
Borisevich
I V
IV
Pantiukhov
V B
VB
Pirozhkov
A P
AP
Syromiatnikova
S I
SI
Shatokhina
I V
IV
Mel'nikov
S A
SA
Shagarov
E E
EE
D000818:Animals; D001117:Arenaviridae Infections / Q000628:therapy*; D006477:Arenaviruses, New World; D004195:Disease Models, Animal; D004306:Dose-Response Relationship, Immunologic; D004353:Drug Evaluation, Preclinical; D006168:Guinea Pigs; D007136:Immunoglobulins / Q000008:administration & dosage* / Q000276:immunology*; D007273:Injections, Intramuscular
D007136:Immunoglobulins