title: Potential-guided versus anatomic-guided approach for slow pathway ablation of the common type atrioventricular nodal reentry tachycardia: a randomized study.
abstract: OBJECTIVE
  The present study aimed to compare the effectiveness and safety of the potential- and the anatomic-guided approach for slow pathway ablation in patients with recurrent episodes of symptomatic common type atrioventricular (AV) nodal reentrant tachycardia.
  
  
  METHODS
  Two hundred and twenty-eight patients were randomly assigned to undergo either a potential- (n=114, 47% men, mean age 52.85 +/- 14.04 years) or an anatomic-guided approach (n=114, 50% men, mean age 52.45 +/- 14.46 years) for radiofrequency ablation of the slow pathway.The mean duration of the follow-up period was 26.7 +/- 7.9 and 24.8 +/- 7.6 months in the potential- and anatomic- guided approach, respectively (P > 0.05).
  
  
  RESULTS
  The success rate for slow pathway ablation was 100% in both ablative methods.The mean duration of atrial electrograms at the successful ablation sites of the potential- and the anatomic-guided approaches was 69 +/- 14 msec and 57 +/- 10 msec, respectively (P = 0.001).There were no significant differences between the potential- and the anatomic-guided approach regarding the duration of the procedure (121.13 +/- 56.83 vs. 109.93 +/- 57.12 min, P = 0.139), the duration of fluoroscopic exposure (6.12 +/- 3.32 vs. 6.64 +/- 3.33 min, P = 0.239) or the mean number of radiofrequency applications delivered (3.96 +/- 2.77 vs. 4.33 +/- 2.73, P = 0.311). Residual dual AV nodal pathway following successful ablation was observed in 9.6% of patients who underwent the potential-guided approach and in 23.7% of patients who underwent the anatomic method (P = 0.004). During followup, arrhythmia recurrence was observed in four patients (1.8%), two in each group (P > 0.05).
  
  
  CONCLUSIONS
  The efficacy and safety of the slow pathway ablation is very high using either the potential- or the anatomic-guided approach.
authors.affiliation: Second Department of Cardiology, Evangelismos General Hospital of Athens, Athens, Greece.
authors.forename: Michael
authors.initials: M
authors.lastname: Efremidis
authors.forename: Antonios
authors.initials: A
authors.lastname: Sideris
authors.forename: Konstantinos P
authors.initials: KP
authors.lastname: Letsas
authors.forename: Ioannis P
authors.initials: IP
authors.lastname: Alexanian
authors.forename: Loukas K
authors.initials: LK
authors.lastname: Pappas
authors.forename: Constantinos C
authors.initials: CC
authors.lastname: Mihas
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Manolatos
authors.forename: Sotirios
authors.initials: S
authors.lastname: Xydonas
authors.forename: Gerasimos
authors.initials: G
authors.lastname: Gavrielatos
authors.forename: Gerasimos S
authors.initials: GS
authors.lastname: Filippatos
authors.forename: Fotios
authors.initials: F
authors.lastname: Kardaras
mesh_terms: D017115:Catheter Ablation / Q000379:methods*; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D013611:Tachycardia, Atrioventricular Nodal Reentry / Q000601:surgery*