title: Intracranial aneurysms in childhood: report of 8 cases and review of the literature.
abstract: OBJECTIVE
  Subarachnoid haemorrhage (SAH) due to ruptured cerebral aneurysms is a rare diagnosis in childhood and is believed to differ from that in adults with regard to sex, aneurysm size and location, clinical appearance as well as outcome, suggesting that aneurysms in childhood are a distinct entity.
  
  
  METHODS
  Seven children and young adults with a mean age of 13.6 years suffered from aneurysmal subarachnoid haemorrhage. On admission two patients were Hunt & Hess (HH) grade I, four were grade III and one was grade V. In addition, there was one 14-year-old boy who presented with seizures and was found to have a non-ruptured aneurysm of the basilar tip. Overall, there were two female and six male patients. Anterior circulation aneurysms were diagnosed in five patients whereas three patients suffered from posterior circulation aneurysm. Five large (10-25 mm) aneurysms and three smaller than 10 mm were found. Surgical clipping of the aneurysms was performed in all patients.
  
  
  RESULTS
  Six patients showed no significant disability or no symptoms at all when evaluated with the modified Rankin Scale (mRS 0 or 1). One patient suffered from persisting nerve palsies (mRS 2) and one 6-year-old boy, admitted with HH grade V, died due to the initial poor clinical condition followed by severe brain oedema and secondary complications.
  
  
  CONCLUSIONS
  Reviewing the literature, a male predominance, low rate of SAH, high percentage of complex aneurysms and of aneurysms located in the posterior circulation are characteristic features of aneurysms in childhood. Once a cerebral aneurysm is diagnosed in the younger age group, definite therapy should be performed soon as the outcome is expected to be more favourable than in adulthood.
authors.affiliation: Neurochirurgische Klinik, Universitätsklinikum Hamburg - Eppendorf, Germany. j.regelsberger@uke.uni-hamburg.de
authors.forename: J
authors.initials: J
authors.lastname: Regelsberger
authors.forename: O
authors.initials: O
authors.lastname: Heese
authors.forename: T
authors.initials: T
authors.lastname: Martens
authors.forename: T
authors.initials: T
authors.lastname: Ries
authors.forename: P
authors.initials: P
authors.lastname: Kunkel
authors.forename: M
authors.initials: M
authors.lastname: Westphal
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000175:diagnosis* / Q000453:epidemiology / Q000601:surgery*; D008297:Male; D013345:Subarachnoid Hemorrhage / Q000175:diagnosis* / Q000453:epidemiology / Q000601:surgery*; D016896:Treatment Outcome; D055815:Young Adult