Evaluating Lynch syndrome in very early onset colorectal cancer probands without apparent polyposis.
To characterize the frequency of germline mutations associated with Lynch syndrome and review the potential expanded differential diagnoses in very early onset colorectal cancer (CRC) cases without apparent polyposis. Retrospectively reviewed medical records of 96 probands with CRC diagnosed prior to age 36 from three cancer centers. Determined the frequency of germline mutations in probands meeting different clinical criteria used to identify Lynch syndrome. Three of 46 (6.5%) single case indicators (probands without additional personal or family history suspicious for Lynch syndrome) were identified to carry a deleterious or suspected deleterious mismatch repair (MMR) mutation compared with 10 of 19 (52.6%) in the cases meeting at least one additional revised Bethesda guideline, and 11 of 15 (73.3%) in the cases meeting Amsterdam criteria. Two families without MMR mutations were documented to have a germline APC or TP53 mutation after additional clinical features were identified. Our results suggest that single cases of CRC (those without additional personal or family history suspicious of Lynch syndrome) diagnosed prior to age 36 infrequently have identifiable MMR mutations, especially when compared to cases meeting additional criteria. Careful attention to evolving or additional clinical features is warranted and may lead to an alternate genetic diagnosis in families with early onset CRC.
Jasperson
Kory W
KW
Cancer Screening & Prevention Program, City of Hope Cancer Center, Duarte, CA, USA. kory.jasperson@hci.utah.edu
Vu
Thuy M
TM
Schwab
Angela L
AL
Neklason
Deborah W
DW
Rodriguez-Bigas
Miguel A
MA
Burt
Randall W
RW
Weitzel
Jeffrey N
JN
D011125:Adenomatous Polyposis Coli / Q000175:diagnosis / Q000235:genetics*; D000293:Adolescent; D000328:Adult; D015331:Cohort Studies; D015179:Colorectal Neoplasms / Q000235:genetics / Q000503:physiopathology*; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000175:diagnosis / Q000235:genetics*; D053843:DNA Mismatch Repair; D003937:Diagnosis, Differential; D005260:Female; D020022:Genetic Predisposition to Disease; D018095:Germ-Line Mutation; D006801:Humans; D008297:Male; D010375:Pedigree; D012189:Retrospective Studies; D055815:Young Adult