title: Separation and analysis of dimethylaniline isomers by supercritical fluid chromatography--electrospray ionization tandem mass spectrometry.
abstract: The assessment of human exposure to specific isomers of dimethylanilines (DMA's) is of interest for the evaluation of potential exposure-health outcome relationships. Improved analytical methods will help in identifying the environmental sources of such exposures. The separation of all six DMA isomers by supercritical fluid chromatography (SFC), without derivatization, is reported within. Further, the combination of SFC with electrospray ionization/tandem mass spectrometry provides selective detection in crude extracts of spiked (40 ppb of 3,5-dimethylaniline) raw materials. The raw materials chosen for analysis are commonly used in the manufacture of consumer hair-dye products.
authors.affiliation: Global Analytical DS2-1D1, The Procter & Gamble Company, Mason Business Center, 8700 Mason-Montgomery Road, Mason, OH 45040, USA. strife.rj@pg.com
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Strife
authors.forename: Michele L
authors.initials: ML
authors.lastname: Mangels
authors.forename: Julie A
authors.initials: JA
authors.lastname: Skare
mesh_terms: D000814:Aniline Compounds / Q000032:analysis* / Q000302:isolation & purification; D025924:Chromatography, Supercritical Fluid / Q000379:methods*; D045424:Complex Mixtures / Q000737:chemistry; D003959:Diamines / Q000032:analysis*; D006202:Hair Dyes / Q000737:chemistry; D007536:Isomerism; D009153:Mutagens / Q000737:chemistry; D010636:Phenols / Q000032:analysis*; D011720:Pyrazoles / Q000032:analysis*; D021241:Spectrometry, Mass, Electrospray Ionization; D053719:Tandem Mass Spectrometry
chemical_list: D000814:Aniline Compounds; D045424:Complex Mixtures; D003959:Diamines; D006202:Hair Dyes; D009153:Mutagens; D010636:Phenols; D011720:Pyrazoles; C514328:3,5-dimethylaniline; C009694:2,4-xylidine; C007766:2,6-xylidine; C016835:2,5-xylidene; C018691:3,4-xylidine