title: A nanosensory device fabricated on a liposome for detection of chemical signals.
abstract: This paper describes construction of a nanosensory device for amplified detection of biologically important amines as chemical signals. The device was inspired by a biological signal transduction system, and was fabricated on an artificial cell membrane through self-organization of the molecular components, such as a synthetic receptor and a natural enzyme. Selective recognition of biologically important amines was achieved by a synthetic receptor with a pyridoxal moiety, as evaluated by means of electronic absorption spectroscopy. The selectivity in detecting amines as chemical signals mainly depends on hydrophobicity of the amines. The event upon detecting the chemical signals was transmitted to an enzyme by a metal ion acting as a mediator species, and then the enzyme amplified the event by the catalytic reaction to obtain signal output. This paper is realization of a biomimetic signal transduction system using amines as chemical signals and may provide a useful guidepost for designing integrated nanosystems.
authors.affiliation: Graduate School of Materials Science, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara 630-0192, Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Sasaki
authors.forename: Yuka
authors.initials: Y
authors.lastname: Shioyama
authors.forename: Wen-Jie
authors.initials: WJ
authors.lastname: Tian
authors.forename: Jun-Ichi
authors.initials: J
authors.lastname: Kikuchi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hiyama
authors.forename: Yuki
authors.initials: Y
authors.lastname: Moritani
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Suda
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation; D007770:L-Lactate Dehydrogenase / Q000737:chemistry; D008081:Liposomes / Q000737:chemistry*; D008954:Models, Biological; D015394:Molecular Structure; D036103:Nanotechnology
chemical_list: D008081:Liposomes; D007770:L-Lactate Dehydrogenase