title: [Endoscopic ultrasound-guided needle aspiration in lung cancer].
abstract: BACKGROUND
  The aim of the study was to assess the diagnostic yield of transoesophageal endoscopic ultrasound-guided needle aspiration (EUS-NA) in lung cancer (LC).
  
  
  METHODS
  Real time EUS-NA was performed under local anaesthesia and sedation in consecutive LC patients. All negative EUS-NA results in NSCLC patients were verified by transcervical extended bilateral mediastinal lymphadenectomy (TEMLA).
  
  
  RESULTS
  In 146 patients there were 206 biopsies performed in lymph node stations: subcarinal (7):124, left lower paratracheal (4L):70, paraoesophageal (8):9 and pulmonary ligament (9):3. A mean short axis of punctured node was 10+/-6.3 (95% CI) mm. Lymph node biopsy was technically successful in 95.6% and was diagnostic in 40.1% of LC patients. In NSCLC staging, the sensitivity of EUS-NA calculated on the per-patient basis was 85.5%, specificity 100%, accuracy 93.6% and negative predictive value (NPV) 89.7% in stations accessible for EUS-NA, but in all mediastinal stations it was 70.7%, 100%, 84.3% and 74.7, respectively (p=0.009). The sensitivity of EUS-NA in NSCLC staging patients, calculated on the per-biopsy basis was 88.6%, specificity 100%, accuracy 95.4% and NPV 91.4%. A diagnostic yield of EUS-NA on the per-biopsy basis was higher for station 4L than 7, but the difference was not significant (chi2 p=0.4).
  
  
  CONCLUSIONS
  The diagnostic value of EUS-NA in LC is high. In NSCLC staging EUS-NA is insufficient and should be complemented by other invasive techniques, especially those that give access to the right paratracheal region.
authors.affiliation: Oddział Torakochirurgii i Pracownia Bronchoskopii Samodzielnego Publicznego Specjalistycznego Szpitala Chorób Płuc w Zakopanem, Zakopane. artondo@mp.pl
authors.forename: Artur
authors.initials: A
authors.lastname: Szlubowski
authors.forename: Marcin
authors.initials: M
authors.lastname: Zieliński
authors.forename: Joanna
authors.initials: J
authors.lastname: Figura
authors.forename: Jolanta
authors.initials: J
authors.lastname: Hauer
authors.forename: Witold
authors.initials: W
authors.lastname: Sośnicki
authors.forename: Juliusz
authors.initials: J
authors.lastname: Pankowski
authors.forename: Anna
authors.initials: A
authors.lastname: Obrochta
authors.forename: Magdalena
authors.initials: M
authors.lastname: Jakubiak
mesh_terms: D000368:Aged; D044963:Biopsy, Fine-Needle / Q000379:methods*; D002289:Carcinoma, Non-Small-Cell Lung / Q000000981:diagnostic imaging* / Q000473:pathology*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging / Q000379:methods; D011237:Predictive Value of Tests; D012107:Research Design; D012680:Sensitivity and Specificity; D018084:Ultrasonography, Interventional / Q000379:methods