title: Effect of radiographic contrast media on markers of complement activation and apoptosis in patients with chronic coronary artery disease undergoing coronary angiography.
abstract: The effects of radiographic contrast media on markers of complement activation and apoptosis in patients with chronic coronary artery disease (CAD) are unknown. The purpose of this study was to assess the comparative effects of ionic high-osmolar and non-ionic iso-osmolar radiographic contrast media on plasma markers of complement activation and apoptosis in patients with chronic CAD undergoing coronary angiography. Forty-four patients undergoing coronary angiography for chronic CAD were randomly assigned to receive the ionic high-osmolar radiographic contrast agent diatrizoate (Group A), or the non-ionic iso-osmolar contrast agent iodixanol (Group B) during angiography. Complement component 5 (C5a) and apoptotic markers sFas and sFasL were measured just prior to angiography and 1 hour after completion of angiography. Comparison of mean pre- and post-angiography plasma marker levels showed significantly greater increases in plasma levels in Group A than in Group B of C5a (29.30 +/- 5.45 ng/ml for Group A and 0.47 +/- 0.70 ng/ml for Group B (p < 0.00001), sFas (2.36 +/- 1.63 ng/ml for Group A and 0.23 +/- 0.90 ng/ml for Group B (p < 0.00001) and sFasL (14.00 +/- 5.41 pg/ml for Group A and 0.01 +/- 1.00 pg/ml for Group B (p < 0.00001). The results suggest that in patients with chronic CAD, the use of ionic high-osmolar radiographic contrast media during coronary angiography is associated with a more robust inflammatory and apoptotic milieu than that associated with the use of non-ionic iso-osmolar radiographic contrast media.
authors.affiliation: Department of Cardiology, Athens General Hospital, Athens, Greece.
authors.forename: Spyridon
authors.initials: S
authors.lastname: Deftereos
authors.forename: Georgios
authors.initials: G
authors.lastname: Giannopoulos
authors.forename: Charalampos
authors.initials: C
authors.lastname: Kossyvakis
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Raisakis
authors.forename: Andreas
authors.initials: A
authors.lastname: Kaoukis
authors.forename: Metaxia
authors.initials: M
authors.lastname: Driva
authors.forename: Olga
authors.initials: O
authors.lastname: Ntzouvara
authors.forename: Vasiliki
authors.initials: V
authors.lastname: Panagopoulou
authors.forename: Ilias
authors.initials: I
authors.lastname: Rentoukas
authors.forename: Dimitrios J
authors.initials: DJ
authors.lastname: Nikas
authors.forename: Vlasios
authors.initials: V
authors.lastname: Pyrgakis
authors.forename: Martin A
authors.initials: MA
authors.lastname: Alpert
mesh_terms: D000368:Aged; D017209:Apoptosis / Q000187:drug effects* / Q000502:physiology; D015415:Biomarkers / Q000097:blood; D003167:Complement Activation / Q000187:drug effects* / Q000502:physiology; D015936:Complement C5a / Q000378:metabolism; D003287:Contrast Media / Q000494:pharmacology; D017023:Coronary Angiography / Q000379:methods*; D003324:Coronary Artery Disease / Q000097:blood* / Q000000981:diagnostic imaging*; D003973:Diatrizoate / Q000494:pharmacology*; D053222:Fas Ligand Protein / Q000097:blood; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009994:Osmolar Concentration; D014283:Triiodobenzoic Acids / Q000494:pharmacology*; D019014:fas Receptor / Q000097:blood
chemical_list: D015415:Biomarkers; D003287:Contrast Media; D053222:Fas Ligand Protein; D014283:Triiodobenzoic Acids; D019014:fas Receptor; D003973:Diatrizoate; D015936:Complement C5a; C044834:iodixanol