title: Putative fat fighter hits the middle man.
abstract: In this issue, Kamisuki and colleagues characterize fatostatin. This compound inhibits the activity of SREBPs, the master transcription factors of lipid homeostasis. This useful laboratory tool also improved the lipid profile of obese mice; does this have clinical implications?
authors.affiliation: University of New South Wales, Sydney, Australia.
authors.forename: James Robert
authors.initials: JR
authors.lastname: Krycer
authors.forename: Andrew John
authors.initials: AJ
authors.lastname: Brown
mesh_terms: D000818:Animals; D005227:Fatty Acids / Q000096:biosynthesis* / Q000378:metabolism; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism; D051379:Mice; D011485:Protein Binding; D051779:Sterol Regulatory Element Binding Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D013844:Thiazoles / Q000494:pharmacology*; D014158:Transcription, Genetic
chemical_list: D005227:Fatty Acids; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; C102196:SREBP cleavage-activating protein; D051779:Sterol Regulatory Element Binding Proteins; D013844:Thiazoles