[Allelic polymorphism of the IL-2and IL-4 genes in herpesvirus infection].
Herpesvirus infection is accompanied by imbalance of peripheral mononuclear production of cytokines, by polarizing an immune response by the Th2 pathway. The homozygous TT genotype of T330G polymorphism in the IL-2 gene is an immunogenetic factor that has a protective activity against susceptibility to herpesvirus infection. The risk of progression, the recurrent course of the infection and its poor outcome is positively associated with the heterozygous TG genotype in the IL-2 gene T-330G promoter region and with the homozygous CC type and C allele in the IL-4 gene C-590T promoter region.
Naslednikova
I O
IO
Novitskiĭ
V V
VV
Urazova
O I
OI
Gorbunova
E B
EB
Sukhalentseva
N A
NA
Chernov
A S
AS
Reshetnikov
V I
VI
Shperling
N V
NV
Pronina
N A
NA
Chaĭkovskiĭ
A V
AV
Chernova
E N
EN
Bezmenova
M A
MA
Sharopina
A V
AV
Voronkova
O V
OV
D000293:Adolescent; D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006566:Herpesviridae Infections / Q000235:genetics* / Q000276:immunology / Q000821:virology; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D007376:Interleukin-2 / Q000097:blood / Q000235:genetics*; D015847:Interleukin-4 / Q000097:blood / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D013601:T-Lymphocytes / Q000276:immunology; D055815:Young Adult
D007376:Interleukin-2; D015847:Interleukin-4