Highly selective and sensitive heparin probing from supramolecular assembly of pyrene derivatives.
A new quinine derivative PQ, bearing pyrenyl as a fluorophore, was prepared to recognize heparin in aqueous solution. PQ exhibits good selectivity and sensitivity for heparin over other biological molecules. Upon binding with heparin, PQ shows a typical excimer emission peaked at 489 nm along with a weak monomer emission at 376 nm. Moreover, PQ also shows good performance to detect the heparin in serum.
Zeng
Lintao
L
Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.
Wang
Pengfei
P
Zhang
Hongyan
H
Zhuang
Xiaoqing
X
Dai
Qing
Q
Liu
Weimin
W
D005456:Fluorescent Dyes / Q000737:chemistry*; D046911:Macromolecular Substances / Q000138:chemical synthesis / Q000737:chemistry; D008968:Molecular Conformation; D011721:Pyrenes / Q000138:chemical synthesis* / Q000737:chemistry; D011803:Quinine / Q000031:analogs & derivatives / Q000737:chemistry*; D013237:Stereoisomerism
D005456:Fluorescent Dyes; D046911:Macromolecular Substances; D011721:Pyrenes; D011803:Quinine