[Diagnostic value of a thiol-disulfide groups of the antioxidant system in brucellosis].
The functional state of a thiol disulfide link of the antioxidant system was evaluated in 322 patients with brucellosis (160 and 162 with its acute and chronic forms, respectively), including the patients with that involving the cardiovascular systems (120 and 92 with acute and chronic forms, respectively). Examination of the blood antioxidant system indicated that in brucellosis patients, cardiovascular involvement was accompanied by a reduction in SH groups and thiol disulfide coefficient and by an increase in the content of SS groups, which indicates the predominance of the oxidant system over antioxidant one. At the same time, the functional insufficiency of the blood antioxidant system was more evident in patients with acute brucellosis.
Iushchuk
N D
ND
Akhmedova
M D
MD
Vasiuk
Iu A
IuA
D000208:Acute Disease; D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D002006:Brucellosis / Q000097:blood* / Q000150:complications / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000097:blood* / Q000150:complications / Q000378:metabolism; D002908:Chronic Disease; D004220:Disulfides / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D009262:Nails; D011237:Predictive Value of Tests; D013438:Sulfhydryl Compounds / Q000097:blood*
D000975:Antioxidants; D004220:Disulfides; D013438:Sulfhydryl Compounds