title: Body weight change in women receiving adjuvant chemotherapy for breast cancer: a French prospective study.
abstract: OBJECTIVE
  Adjuvant chemotherapy has frequently been associated with weight gain after breast cancer diagnosis. We aimed to prospectively evaluate body weight variations in French patients with early breast cancer.
  
  
  METHODS
  This prospective observational study included 272 breast cancer patients who were candidates for adjuvant chemotherapy. Weight and body mass index were measured at baseline visit, then at 9 and 15 months from baseline (6 and 12-month post-chemotherapy). At baseline visit, information on the benefits of weight gain prevention and healthy diet was given by a dietician. Univariate logistic regression was performed to test the association between weight gain and potential predictive factors.
  
  
  RESULTS
  Thirty percent of patients gained weight during the year before diagnosis, 26% were overweight and 15% were obese. At one year, the mean weight change was +1.5kg (SD=4.1) and +2.3% (SD=6.0); 60% of the cohort had gained weight, with a median increase of 3.9kg (SD=3.0) and 5.9% (SD=4.4). Reported weight gain during the year before diagnosis appears to be the only factor associated with the absence of post-chemotherapy weight gain (OR=0.54, 95% CI [0.31-0.95], p=0.034).
  
  
  CONCLUSIONS
  Body weight increased in the post-chemotherapy period in French breast cancer survivors, even when given dietary recommendations. Appropriate weight management interventions with nutritional follow-up and physical activity programs are needed.
authors.affiliation: Université de Lyon - Centre Léon Bérard, Department of Medical Oncology, 28 rue Laennec, 69008 Lyon, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Trédan
authors.forename: Agathe
authors.initials: A
authors.lastname: Bajard
authors.forename: Anne
authors.initials: A
authors.lastname: Meunier
authors.forename: Pascale
authors.initials: P
authors.lastname: Roux
authors.forename: Ingrid
authors.initials: I
authors.lastname: Fiorletta
authors.forename: Thérèse
authors.initials: T
authors.lastname: Gargi
authors.forename: Thomas
authors.initials: T
authors.lastname: Bachelot
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Guastalla
authors.forename: Yolande
authors.initials: Y
authors.lastname: Lallemand
authors.forename: Christelle
authors.initials: C
authors.lastname: Faure
authors.forename: David
authors.initials: D
authors.lastname: Pérol
authors.forename: Patrick
authors.initials: P
authors.lastname: Bachmann
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging; D000886:Anthropometry; D015992:Body Mass Index; D001835:Body Weight / Q000187:drug effects; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D002277:Carcinoma / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D015331:Cohort Studies; D004032:Diet; D055088:Early Detection of Cancer; D005260:Female; D005500:Follow-Up Studies; D005602:France; D006801:Humans; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D010353:Patient Education as Topic; D017698:Postmenopause; D017697:Premenopause; D011446:Prospective Studies; D013997:Time Factors; D055815:Young Adult