The potential role of curcumin in patients with monoclonal gammopathy of undefined significance--its effect on paraproteinemia and the urinary N-telopeptide of type I collagen bone turnover marker.
OBJECTIVE
To determine the effect of curcumin on plasma cells and osteoclasts in patients with MGUS.


METHODS
Twenty-six patients with MGUS were recruited into the study and administered 4 grams/day oral curcumin. Blood and urine samples were collected at specified visits after initiating therapy. Full blood count, B2 microglobulin, serum paraprotein, and immunoglobulin electrophoresis (IEPG and EPG) were determined for all patients at each visit. Serum calcium, 25 hydroxyvitamin D3, and bone-specific alkaline phosphatase were determined at baseline only. Urine, as a morning second-void sample, was collected at each visit for urinary N-telopeptide of type I collagen.


RESULTS
Our results show that oral curcumin is able to decrease paraprotein load in a select group (i.e., those having a paraprotein level of >20 g/L) of patients with MGUS. Fifty percent (5 of 10) of these patients had a 12% to 30% reduction in their paraprotein levels, while on curcumin therapy. In addition, 27% of patients on curcumin had a >25% decrease in urinary N-telopeptide of type I collagen.


CONCLUSIONS
Due to the possible progression of MGUS to multiple myeloma, the potential role of curcumin as a therapeutic intervention for MGUS patients warrants further investigation.
Golombick
Terry
T
Department of Endocrinology, St. George Hospital, Sydney and Southern Sydney Haematology, University of Wollongong, New South Wales, Australia. terry.golombick@sesiahs.health.nsw.gov.au
Diamond
Terrence H
TH
Badmaev
Vladimir
V
Manoharan
Arumugam
A
Ramakrishna
Rajeev
R
D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood / Q000378:metabolism / Q000652:urine; D001842:Bone and Bones / Q000187:drug effects* / Q000378:metabolism; D003094:Collagen / Q000097:blood / Q000378:metabolism* / Q000652:urine; D003474:Curcumin / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010265:Paraproteinemias / Q000097:blood / Q000188:drug therapy* / Q000652:urine
D015415:Biomarkers; C461299:urinary N-telopeptide of type I collagen, human; D003094:Collagen; D003474:Curcumin