title: Partial occlusion of the descending aorta increases cerebral blood flow in a nonstroke porcine model.
abstract: BACKGROUND
  We studied the effect of partial aortic occlusion on cerebral perfusion and cardiac performance using the intra-aortic NeuroFlo catheter.
  
  
  METHODS
  Adult pigs were instrumented to determine cardiac parameters; unique isotope-labeled microspheres were used to determine cerebral blood flow (CBF) before, during and after sequential partial aortic occlusion.
  
  
  RESULTS
  Six pigs were studied; there was no relevant change in cardiac output, and the desired pressure drop of 10-15 mm Hg across the balloons was achieved. CBF increased significantly with inflation of the suprarenal balloon and remained elevated 90 min after deflation.
  
  
  CONCLUSIONS
  Partial aortic occlusion with the NeuroFlo catheter significantly increased cerebral perfusion without adversely affecting cardiac performance.
authors.affiliation: Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.
authors.forename: Maxim
authors.initials: M
authors.lastname: Hammer
authors.forename: Tudor
authors.initials: T
authors.lastname: Jovin
authors.forename: Joyce A
authors.initials: JA
authors.lastname: Wahr
authors.forename: Wolf-Dieter
authors.initials: WD
authors.lastname: Heiss
mesh_terms: D000818:Animals; D001013:Aorta, Thoracic / Q000502:physiology*; D021721:Balloon Occlusion / Q000295:instrumentation; D001794:Blood Pressure; D002302:Cardiac Output; D002560:Cerebrovascular Circulation; D005260:Female; D006339:Heart Rate; D008863:Microspheres; D023421:Models, Animal; D011669:Pulmonary Wedge Pressure; D012039:Regional Blood Flow; D012079:Renal Circulation; D034421:Sus scrofa; D013997:Time Factors; D015854:Up-Regulation; D014655:Vascular Resistance