title: The significance of laryngopharyngeal reflux in benign vocal mucosal lesions.
abstract: OBJECTIVE
  To determine the significance of laryngopharyngeal reflux (LPR) in benign vocal mucosal lesions.
  
  
  METHODS
  A case-control study at the tertiary referral medical center.
  
  
  METHODS
  From April 2003 to December 2006, we studied 110 patients with benign vocal mucosal lesions who had undergone 24-hour ambulatory double pH monitoring. The control group included 200 patients who had undergone ambulatory 24-hour double-probe pH monitoring due to laryngopharyngeal reflux-related symptoms without specific findings of benign vocal mucosal lesions. Reflux symptom index and reflux finding score were measured. We compared the prevalence of pathologic laryngopharyngeal reflux and various parameters of the pH monitoring such as total reflux number, fraction time of pH below 4 in various positions, and DeMeester scores.
  
  
  RESULTS
  The prevalence of pathologic laryngopharyngeal reflux was 65 percent in the control group, 66 percent in vocal nodule group, 75 percent in the vocal polyp group, and 90 percent in the Reinke's edema group. Patients with Reinke's edema had a significantly higher prevalence of pathologic laryngopharyngeal reflux than controls (P = 0.016). LPR was associated with a significantly increased risk of Reinke's edema (odds ratio: 4.846, 95% confidence interval 1.093 approximately 21.492). Total reflux number and DeMeester scores in the Reinke's edema group and fraction time of pH below 4 in the supine position in the vocal polyp group were significantly higher than those in the control group.
  
  
  CONCLUSIONS
  Laryngopharyngeal reflux might play a role as an etiologic factor in Reinke's edema and vocal polyps.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Hanyang University, Seoul, Korea.
authors.forename: Jae Ho
authors.initials: JH
authors.lastname: Chung
authors.forename: Kyung
authors.initials: K
authors.lastname: Tae
authors.forename: Yong Seop
authors.initials: YS
authors.lastname: Lee
authors.forename: Jin Hyeok
authors.initials: JH
authors.lastname: Jeong
authors.forename: Seok Hyun
authors.initials: SH
authors.lastname: Cho
authors.forename: Kyung Rae
authors.initials: KR
authors.lastname: Kim
authors.forename: Chul Won
authors.initials: CW
authors.lastname: Park
authors.forename: Dong Soo
authors.initials: DS
authors.lastname: Han
mesh_terms: D000328:Adult; D050782:Esophageal pH Monitoring; D005260:Female; D005500:Follow-Up Studies; D005764:Gastroesophageal Reflux / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D015994:Incidence; D007723:Korea / Q000453:epidemiology; D007820:Laryngeal Mucosa / Q000473:pathology*; D007822:Laryngeal Neoplasms / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology; D008297:Male; D008875:Middle Aged; D011127:Polyps / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology; D015995:Prevalence; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D014827:Vocal Cords