title: Gout. Hyperuricemia and cardiovascular disease: how strong is the evidence for a causal link?
abstract: An association between high levels of serum urate and cardiovascular disease has been proposed for many decades. However, it was only recently that compelling basic science data, small clinical trials, and epidemiological studies have provided support to the idea of a true causal effect. In this review we present recently published data that study the association between hyperuricemia and selected cardiovascular diseases, with a final conclusion about the possibility of this association being causal.
authors.affiliation: Birmingham VA Medical Center, 700 19th St. S, Birmingham, AL 35233, USA. agaffo@uab.edu
authors.forename: Angelo L
authors.initials: AL
authors.lastname: Gaffo
authors.forename: N Lawrence
authors.initials: NL
authors.lastname: Edwards
authors.forename: Kenneth G
authors.initials: KG
authors.lastname: Saag
mesh_terms: D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000209:etiology*; D006073:Gout / Q000150:complications* / Q000453:epidemiology; D006801:Humans; D033461:Hyperuricemia / Q000150:complications* / Q000453:epidemiology; D014527:Uric Acid / Q000097:blood
chemical_list: D014527:Uric Acid