title: Clinical pharmacokinetics and pharmacodynamics of tigecycline.
abstract: Rapid emergence of resistance against antibacterials emphasizes the need for the development of novel and/or more potent antibacterials. Tigecycline is the first representative of a new drug class, the glycylcyclines, and was approved in 2005 by the US FDA for the treatment of complicated skin and skin structure infections, as well as complicated intra-abdominal infections. Tigecycline distributes extensively into the intracellular space of tissue and accumulates in cells, which may qualify it for the treatment of intracellular infections. The pharmacokinetics of tigecycline are complex with both linear and non-linear characteristics. The reason for this complexity is still not fully understood. Non-linearity can be found in the volume of distribution possibly due to extensive and variable tissue and/or plasma protein binding. In contrast, clearance and area under the plasma concentration-time curve are dose-independent. Tigecycline has a high incidence of mild adverse effects, mainly nausea and vomiting, but is otherwise well tolerated.
authors.affiliation: Department of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, Florida 32610, USA.
authors.forename: April
authors.initials: A
authors.lastname: Barbour
authors.forename: Stephan
authors.initials: S
authors.lastname: Schmidt
authors.forename: Benjamin
authors.initials: B
authors.lastname: Ma
authors.forename: Lars
authors.initials: L
authors.lastname: Schiefelbein
authors.forename: Kenneth H
authors.initials: KH
authors.lastname: Rand
authors.forename: Olaf
authors.initials: O
authors.lastname: Burkhardt
authors.forename: Hartmut
authors.initials: H
authors.lastname: Derendorf
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics* / Q000494:pharmacology; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy; D006801:Humans; D008911:Minocycline / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000494:pharmacology; D000078304:Tigecycline
chemical_list: D000900:Anti-Bacterial Agents; D000078304:Tigecycline; D008911:Minocycline