title: Toxoplasma gondii: prototype immunization of lambs against formation of muscle and brain cysts.
abstract: Nine lambs were immunized with 10(6) oocysts of the relatively avirulent ME-49 strain of Toxoplasma gondii, and were challenged 45 days later with 4 x 10(6) oocysts of the M3 strain of this parasite. Less than 5 tissue cysts of the M3 strain formed per 8 g of muscle - if any - judging from a bioassay in mice in which all mice survived. In contrast, mortality occurred in mice fed muscle specimens from 4 lambs that had not been immunized with ME-49 prior to challenge with the M3 strain. This finding suggests the possibility of creating a vaccine for lambs that could diminish or abolish lamb and mutton as sources of human infection with T. gondii, and which could also prevent toxoplasmosis abortion in sheep.
authors.affiliation: Laboratory for Toxoplasmosis, Dept. Parasitology, College of Veterinary Sciences, Montevideo, Uruguay.
authors.forename: J
authors.initials: J
authors.lastname: Falcón
authors.forename: A
authors.initials: A
authors.lastname: Freyre
mesh_terms: D000818:Animals; D001921:Brain / Q000469:parasitology*; D002415:Cats; D051379:Mice; D009132:Muscles / Q000469:parasitology*; D016052:Protozoan Vaccines / Q000276:immunology; D012756:Sheep; D014122:Toxoplasma / Q000276:immunology*; D014124:Toxoplasmosis, Animal / Q000469:parasitology / Q000517:prevention & control*
chemical_list: D016052:Protozoan Vaccines