title: Bioactive SrTiO(3) nanotube arrays: strontium delivery platform on Ti-based osteoporotic bone implants.
abstract: Development of strontium releasing implants capable of stimulating bone formation and inhibiting bone resorption is a desirable solution for curing osteoporosis. In this work, well-ordered SrTiO(3) nanotube arrays capable of Sr release at a slow rate and for a long time are successfully fabricated on titanium by simple hydrothermal treatment of anodized titania nanotubes. This surface architecture combines the functions of nanoscaled topography and Sr release to enhance osseointegration while at the same time leaving space for loading of other functional substances. In vitro experiments reveal that the SrTiO(3) nanotube arrays possess good biocompatibility and can induce precipitation of hydroxyapatite from simulated body fluids (SBF). This Ti-based implant with SrTiO(3) nanotube arrays is an ideal candidate for osteoporotic bone implants. The proposed method can also be extended to load other biologically useful elements such as Mg and Zn.
authors.affiliation: Department of Physics and Materials Science, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, China.
authors.forename: Yunchang
authors.initials: Y
authors.lastname: Xin
authors.forename: Jiang
authors.initials: J
authors.lastname: Jiang
authors.forename: Kaifu
authors.initials: K
authors.lastname: Huo
authors.forename: Tao
authors.initials: T
authors.lastname: Hu
authors.forename: Paul K
authors.initials: PK
authors.lastname: Chu
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry / Q000633:toxicity; D001842:Bone and Bones / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry* / Q000633:toxicity; D006801:Humans; D050997:Nanomedicine; D043942:Nanotubes / Q000737:chemistry*; D010024:Osteoporosis / Q000378:metabolism* / Q000473:pathology; D010087:Oxides / Q000737:chemistry* / Q000633:toxicity; D013324:Strontium / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology / Q000633:toxicity; D013997:Time Factors; D054457:Tissue Scaffolds; D014025:Titanium / Q000737:chemistry* / Q000633:toxicity
chemical_list: D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D010087:Oxides; D014025:Titanium; C119252:strontium titanium oxide; D013324:Strontium