title: Gold nanoparticles functionalized with gadolinium chelates as high-relaxivity MRI contrast agents.
abstract: Water-dispersible gold nanoparticles functionalized with paramagnetic gadolinium have been fully characterized, and the NMRD profiles show very high relaxivities up to 1.5 T. Characterization using TEM images and dynamic light scattering indicate a particle size distribution from 2 to 15 nm. The gold cores of the nanoparticles do not contribute significantly to the overall magnetic moment.
authors.affiliation: Institut des Sciences et Ingénieurie Chimique, Ecole Polytechnique Fédérale de Lausanne, CH 1015 Lausanne, Switzerland.
authors.forename: Loïck
authors.initials: L
authors.lastname: Moriggi
authors.forename: Caroline
authors.initials: C
authors.lastname: Cannizzo
authors.forename: Eddy
authors.initials: E
authors.lastname: Dumas
authors.forename: Cédric R
authors.initials: CR
authors.lastname: Mayer
authors.forename: Alexey
authors.initials: A
authors.lastname: Ulianov
authors.forename: Lothar
authors.initials: L
authors.lastname: Helm
mesh_terms: D003287:Contrast Media / Q000737:chemistry*; D005682:Gadolinium / Q000737:chemistry*; D006046:Gold; D008279:Magnetic Resonance Imaging / Q000379:methods*; D053768:Metal Nanoparticles / Q000737:chemistry; D010316:Particle Size
chemical_list: D003287:Contrast Media; D006046:Gold; D005682:Gadolinium