title: Cost-effectiveness of strontium ranelate versus risedronate in the treatment of postmenopausal osteoporotic women aged over 75 years.
abstract: OBJECTIVE
  To estimate the cost-effectiveness of strontium ranelate in the treatment of postmenopausal osteoporotic women aged over 75 years.
  
  
  METHODS
  A validated Markov microsimulation model with a Belgian payer's perspective estimated the cost per quality-adjusted life-year (QALY) of a 3-year strontium ranelate treatment compared with no treatment and with the bisphosphonate risedronate. Data on the effect of both treatments on fracture risk were taken from the Cochrane Database of Systematic Reviews. Analyses were performed for postmenopausal women aged 75 and 80 years, either with a diagnosis of osteoporosis (i.e. bone mineral density T-score <or=-2.5 SD) or with prevalent vertebral fractures (PVF). Parameter uncertainty was evaluated using both one-way and probabilistic sensitivity analyses.
  
  
  RESULTS
  Strontium ranelate was dominant (i.e. more effective and less costly) versus risedronate for women with osteoporosis aged over 75 years and for women with PVF aged 80 years. The cost per QALY gained of strontium ranelate compared with risedronate at 75 years of age was euro 11,435 for women with PVF. When compared with no treatment, the costs per QALY gained of strontium ranelate were euro 15,588 and euro 7,708 at 75 and 80 years of age for women with osteoporosis; the equivalent values were euro 16,518 and euro 6,015 for women with PVF. Probabilistic sensitivity analyses showed that strontium ranelate was generally more cost-effective than risedronate, in the range of 60% in all cases.
  
  
  CONCLUSIONS
  The results of this study suggest that strontium ranelate is a cost-effective strategy, in a Belgian setting, for the treatment of postmenopausal osteoporotic women aged over 75 years.
authors.affiliation: HEC-ULg Management School, University of Liège, Boulevard du Rectorat 7, Bât B31, 4000 Liège, Belgium. m.hiligsmann@ulg.ac.be
authors.forename: Mickaël
authors.initials: M
authors.lastname: Hiligsmann
authors.forename: Olivier
authors.initials: O
authors.lastname: Bruyère
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Reginster
mesh_terms: D000368:Aged; D050071:Bone Density Conservation Agents / Q000191:economics* / Q000627:therapeutic use*; D003362:Cost-Benefit Analysis; D012968:Etidronic Acid / Q000031:analogs & derivatives* / Q000191:economics / Q000627:therapeutic use; D005260:Female; D006801:Humans; D015233:Models, Statistical; D009942:Organometallic Compounds / Q000191:economics* / Q000627:therapeutic use*; D015663:Osteoporosis, Postmenopausal / Q000188:drug therapy* / Q000191:economics*; D019057:Quality-Adjusted Life Years; D000068296:Risedronic Acid; D013876:Thiophenes / Q000191:economics* / Q000627:therapeutic use*
chemical_list: D050071:Bone Density Conservation Agents; D009942:Organometallic Compounds; D013876:Thiophenes; C081587:strontium ranelate; D000068296:Risedronic Acid; D012968:Etidronic Acid