Synthesis of a neonicotinoide pesticide derivative via chemoenzymatic dynamic kinetic resolution.
Chemoenzymatic dynamic kinetic resolution (DKR) via combined ruthenium and enzyme catalysis was used in the key step of a synthesis of a neonicotinoid pesticide derivative (S)-3. The DKR was carried out under mild conditions with low catalyst loading. The method gives (S)-3 in high enantiomeric excess (98%).
Krumlinde
Patrik
P
Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, SE-106 91 Stockholm, Sweden.
Bogár
Krisztián
K
Bäckvall
Jan-E
JE
D000691:Anabasine / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D005656:Fungal Proteins; D007700:Kinetics; D008049:Lipase / Q000737:chemistry / Q000378:metabolism; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry; D010575:Pesticides / Q000138:chemical synthesis* / Q000737:chemistry; D012428:Ruthenium / Q000737:chemistry; D013237:Stereoisomerism; D013816:Thermodynamics
D005656:Fungal Proteins; D009942:Organometallic Compounds; D010575:Pesticides; D012428:Ruthenium; D008049:Lipase; C431349:lipase B, Candida antarctica; D000691:Anabasine