Membrane glycolipids in stem cells.
Stem cells, such as embryonic stem cells, hematopoietic stem cells, neural stem cells, mesenchymal stem cells, and very small embryonic-like stem cells, are undifferentiated cells that are endowed with a high potential for proliferation and the capacity for self-renewal with retention of pluri/multipotency to differentiate into their progenies. Recently, studies regarding the biological functions of glycolipids and cell surface microdomains (caveolae, lipid rafts, or glycolipid-enriched microdomains) in stem cells are emerging. In this review, we introduce the expression patterns of glycolipids and the functional roles of cell surface microdomains in stem cells.
Yu
Robert K
RK
Institute of Molecular Medicine and Genetics and Institute of Neuroscience, Medical College of Georgia, Augusta, GA 30912, USA. ryu@mcg.edu
Suzuki
Yusuke
Y
Yanagisawa
Makoto
M
D000818:Animals; D006017:Glycolipids / Q000378:metabolism* / Q000502:physiology*; D006801:Humans; D008563:Membrane Lipids / Q000378:metabolism* / Q000502:physiology*; D021962:Membrane Microdomains / Q000378:metabolism / Q000502:physiology; D009474:Neurons / Q000378:metabolism / Q000502:physiology; D013234:Stem Cells / Q000378:metabolism* / Q000502:physiology
D006017:Glycolipids; D008563:Membrane Lipids