title: Pulmonary hyalinizing granuloma.
abstract: OBJECTIVE
  To present clinical and pathologic features of pulmonary hyalnizing granuloma through analyzing three cases found in our institution and reviewing cases reported in the English language literature.
  
  
  RESULTS
  Three cases of pulmonary hyalnizing granuloma identified at our institution during the past ten years were reviewed. In the first case, the patient presented with concurrent pulmonary hyalinizing granuloma and histoplasmosis. In the second case, the patient presented with a 5.5 cm lung mass and a separate smaller lesion radiologically resembling bronchogenic carcinoma. There was very prominent polyclonal lymphocytic proliferation at the periphery especially of the smaller lesion likely representing an early stage of the disease process. In the third case, the patient presented with multiple subpleural plaque-like lesions in addition to nodular lesions of the lung. All cases also demonstrated various degrees of lymphocytic infiltration within the lesions. The English literature has been reviewed through searching the PubMed.
  
  
  CONCLUSIONS
  Since patients with pulmonary hyalinizing granuloma demonstrated a spectrum of clinical presentations, radiologic changes and histologic features with a variety of associated clinical disorders, pulmonary hyalnizing granuloma is more in keeping with a clinicopathologic entity rather than a specific pathologic disease.
authors.affiliation: Department of Pathology, Queen Elizabeth II Health Sciences Centre and Dalhousie University, Halifax, Nova Scotia, Canada B3H 1V8. zxu3@dal.ca
authors.forename: Zhao-lin
authors.initials: ZL
authors.lastname: Xu
authors.forename: Drew
authors.initials: D
authors.lastname: Bethune
authors.forename: Daria
authors.initials: D
authors.lastname: Manos
authors.forename: Annette
authors.initials: A
authors.lastname: Foyle
authors.forename: Harry
authors.initials: H
authors.lastname: Henteleff
authors.forename: Michael
authors.initials: M
authors.lastname: Johnston
authors.forename: Yannick
authors.initials: Y
authors.lastname: Cartier
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D015769:Granuloma, Respiratory Tract / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D006818:Hyalin; D008171:Lung Diseases / Q000000981:diagnostic imaging / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed