p24 proteins play a role in peroxisome proliferation in yeast.
Emp24 is a member of the p24 protein family, which was initially localized to the endoplasmic reticulum, Golgi and COP vesicles, but has recently shown to be associated with Saccharomyces cerevisiae peroxisomes as well. Using cell fractionation and electron- and fluorescence microscopy, we show that in the yeast Hansenula polymorpha, Emp24 also associates with peroxisomes. In addition, we show that peroxisome numbers are strongly decreased in H. polymorpha cells lacking two proteins of the p24 complex, Emp24 and Erp3. Detailed fluorescence microscopy analyses suggest that emp24.erp3 cells are disturbed in peroxisome fission and inheritance.
Kurbatova
Elena
E
Molecular Cell Biology, Groningen Biomolecular Sciences and Biotechnology Institute (GBB), Kluyver Centre for Genomics of Industrial Fermentation, University of Groningen, P.O. Box 14, 9750 AA Haren, The Netherlands.
Otzen
Marleen
M
van der Klei
Ida J
IJ
D005656:Fungal Proteins / Q000235:genetics / Q000502:physiology*; D017353:Gene Deletion; D020675:Peroxisomes / Q000502:physiology*; D010843:Pichia / Q000235:genetics / Q000502:physiology* / Q000648:ultrastructure; D033921:Vesicular Transport Proteins / Q000235:genetics / Q000502:physiology*
D005656:Fungal Proteins; D033921:Vesicular Transport Proteins