Insulators as mediators of intra- and inter-chromosomal interactions: a common evolutionary theme.
Insulator elements mediate intra- and inter-chromosomal interactions. The insulator protein CCCTC-binding factor (CTCF) is important for insulator function in several animals but a report in BMC Molecular Biology shows that Caenorhabditis elegans, yeast and plants lack CTCF. Alternative proteins may have a similar function in these organisms.
Ong
Chin-Tong
CT
Department of Biology, Emory University, 1510 Clifton Road NE, Atlanta, GA 30322, USA.
Corces
Victor G
VG
D000818:Animals; D000076246:CCCTC-Binding Factor; D002875:Chromosomes / Q000235:genetics / Q000378:metabolism*; D019143:Evolution, Molecular; D005786:Gene Expression Regulation; D016678:Genome; D006801:Humans; D038101:Insulator Elements; D012097:Repressor Proteins / Q000502:physiology
D000076246:CCCTC-Binding Factor; C000619697:CTCF protein, human; D012097:Repressor Proteins