Control of vector populations using genetically modified mosquitoes.
The ineffectiveness of current strategies for chemical control of mosquito vectors raises the need for developing novel approaches. Thus, we carried out a literature review of strategies for genetic control of mosquito populations based on the sterile insect technique. One of these strategies consists of releasing radiation-sterilized males into the population; another, of integrating a dominant lethal gene under the control of a specific promoter into immature females. Advantages of these approaches over other biological and chemical control strategies include: highly species-specific, environmentally safety, low production cost, and high efficacy. The use of this genetic modification technique will constitute an important tool for integrated vector management.
Wilke
André Barreto Bruno
AB
Programa de Pós-Graduação em Saúde Pública, Faculdade de Saúde Pública, Universidade de São Paulo, São Paulo, SP, Brasil.
Gomes
Almério de Castro
Ade C
Natal
Delsio
D
Marrelli
Mauro Toledo
MT
D000818:Animals; D030801:Animals, Genetically Modified; D009033:Culicidae / Q000235:genetics*; D005260:Female; D007303:Insect Vectors / Q000235:genetics*; D008297:Male; D009032:Mosquito Control / Q000379:methods*; D012680:Sensitivity and Specificity