title: Lupane triterpene glycosides from leave of Acanthopanax koreanum and their cytotoxic activity.
abstract: One new lupane-triterpene glycoside, acankoreoside I (1), and four known compounds, acankoreoside A (2), acankoreoside D (3), acankoreoside F (4), and acantrifoside A (5), were isolated from the leaves of Acanthopanax koreanum (Araliaceae). Their chemical structures were elucidated by mass, 1D- and 2D-NMR spectroscopy. The structure of new compound 1 was determined to be 3alpha,11alpha,30-trihydroxylup-23-al-20(29)-en-28-oic acid 28-O-[alpha-L-rhamnopyranosyl-(1-->4)-beta-D-glucopyranosyl-(1-->6)-beta-D-glucopyranosyl] ester. The cytotoxic activities of these compounds were evaluated with four cancer cell lines such as A-549 (lung), HL-60 (acute promyelocytic leukemia), MCF-7 (breast), and U-937 (leukemia). Compound 1 showed growth inhibitory effect in A-549, HL-60, and MCF-7 cell lines with the IC(50) values of 8.2 microM, 12.1 microM, and 28.6 microM, respectively, whereas it was less active in the U937 cell line (the IC(50) >100 microM).
authors.affiliation: Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, Vietnam.
authors.forename: Nguyen Xuan
authors.initials: NX
authors.lastname: Nhiem
authors.forename: Nguyen Huu
authors.initials: NH
authors.lastname: Tung
authors.forename: Phan Van
authors.initials: PV
authors.lastname: Kiem
authors.forename: Chau Van
authors.initials: CV
authors.lastname: Minh
authors.forename: Yan
authors.initials: Y
authors.lastname: Ding
authors.forename: Jae-Hee
authors.initials: JH
authors.lastname: Hyun
authors.forename: Hee-Kyoung
authors.initials: HK
authors.lastname: Kang
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Kim
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D028001:Eleutherococcus / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology / Q000633:toxicity; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D018515:Plant Leaves / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D053978:Pentacyclic Triterpenes
chemical_list: D000970:Antineoplastic Agents; D006027:Glycosides; D014315:Triterpenes; C545002:acankoreoside I; C480546:lupane; D053978:Pentacyclic Triterpenes