title: Inhibition and prevention efficacy against mosquito bloodsucking and Dirofilaria immitis infection by administration of topical insecticide.
abstract: Inhibition and prevention of mosquito bloodsucking by a topical insecticide, and the consequent infection of Dirofilaria immitis were evaluated using a product containing 10% w/w imidacloprid plus 50% w/w permethrin (I-P solution). Nine healthy beagle dogs divided in three groups of 3 dogs each were administered I-P solution on day 3 (group 1), day 36 (group 2) and not administered (group 3 as a control) before starting the experimental infection. The results showed that the mosquito bloodsucking rate was significantly lower, 12.1% in group 1 (p<0.05) and 11.1% in group 2 (p<0.05), than the 40.6% in group 3, meaning that the inhibition rates in groups 1 and 2 against group 3 were 70.2% and 72.7%. The infection rate of experimental D. immitis infection was 33% in group 1, 33% in group 2 and 100% in group 3, meaning that the prevention rates in groups 1 and 2 against group 3 were 67% and 67%.
authors.affiliation: School of Veterinary Medicine, Yamaguchi University, Yamaguchi, Japan. hayasaki@yamaguchi-u.ac.jp
authors.forename: Mineo
authors.initials: M
authors.lastname: Hayasaki
authors.forename: Hideharu
authors.initials: H
authors.lastname: Saeki
mesh_terms: D000287:Administration, Topical; D000818:Animals; D009033:Culicidae / Q000502:physiology; D004183:Dirofilaria immitis / Q000187:drug effects*; D004184:Dirofilariasis / Q000097:blood / Q000517:prevention & control*; D004283:Dog Diseases / Q000097:blood / Q000188:drug therapy*; D004285:Dogs; D005260:Female; D007093:Imidazoles / Q000008:administration & dosage / Q000627:therapeutic use; D007306:Insecticides / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D000073943:Neonicotinoids; D009574:Nitro Compounds / Q000008:administration & dosage / Q000627:therapeutic use; D026023:Permethrin / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D007093:Imidazoles; D007306:Insecticides; D000073943:Neonicotinoids; D009574:Nitro Compounds; C082359:imidacloprid; D026023:Permethrin