Role of matrix metalloproteinases in coronary artery disease.
OBJECTIVE
Matrix metalloproteinases (MMPs) contribute both in the formation as well as in the destabilization of atherosclerotic plaque. In the present study we analyzed circulating levels of MMP-7 that acts on chondroitin sulphate a proteoglycan that is particularly abundant in atherosclerotic plaque and MMP-8 which acts on Type I collagen, the synthesis and degradation of which is important for stability of the plaque and correlate with the degree of severity of coronary artery disease (CAD).


METHODS
Circulating levels of MMP-7 and MMP-8 and tissue inhibitors of MMP (TIMP) -1 and TIMP-2 were analysed by Enzyme Linked ImmunoSorbent Assay (ELISA7rpar;, in patients with acute myocardial infarction (AMI) at presentation (N=48), acute coronary syndrome (ACS) group (N=227rpar; (on treatment) and stable angina group (N=17) (on treatment).


RESULTS
There was significant rise in MMP-8 (88.23%, P=0.001), in AMI group which decreased in ACS treated group 7lpar;15.9%, non-significant) as compared to controls. There was increasing trend of MMP-7 in AMI and ACS group and strong correlation with hsCRP. MMP-7 predominated in stable angina group. There was significant decrease in TIMP-2 in AMI group and TIMP-1 and TIMP-2 in ACS and stable angina group as compared to controls.


CONCLUSIONS
Significant increase in MMP-8 and decrease in TIMP-2 during acute stage of AMI suggests MMP-8 and TIMP-2 are markers for vulnerable plaque independent of hsCRP for AMI. MMP-7 was found to be elevated in stable angina patients and was correlated with hsCRP at acute phase of AMI suggesting persistent at all stages of CAD.
Shah
Vinod K
VK
Sir H. N. Hospital and Research Centre, Raja Rammohan Roy Road, Mumbai, India.
Shalia
Kavita K
KK
Mashru
Manoj R
MR
Soneji
Surendra L
SL
Abraham
Ajin
A
Kudalkar
Ketki V
KV
Vasvani
Jagdish B
JB
Sanghavi
Snehal T
ST
D000328:Adult; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000201:enzymology*; D005260:Female; D006801:Humans; D008297:Male; D020782:Matrix Metalloproteinases; D008875:Middle Aged
D020782:Matrix Metalloproteinases