title: In situ treatment of an infected intrathecal baclofen pump implant with gentamicin-impregnated collagen fleece.
abstract: Intrathecal delivery of baclofen using a subcutaneous pump is an effective long-term treatment for spasticity. Infections of the pocket, however, are often hard to eliminate with intravenous antibiotics. If a 2-stage procedure involving removal of the pump and baclofen withdrawal will create serious problems for the patient, infections can be treated with repetitive local application of gentamicin-impregnated collagen fleece.
authors.affiliation: Department of Neurosurgery, Vrije Universiteit Medical Center, Amsterdam, The Netherlands.
authors.forename: Saskia M
authors.initials: SM
authors.lastname: Peerdeman
authors.forename: Vincent
authors.initials: V
authors.lastname: de Groot
authors.forename: Ricardo E
authors.initials: RE
authors.lastname: Feller
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001418:Baclofen / Q000008:administration & dosage*; D003094:Collagen; D003646:Debridement; D004343:Drug Implants; D005839:Gentamicins / Q000008:administration & dosage*; D006801:Humans; D015918:Infusion Pumps, Implantable / Q000382:microbiology*; D007278:Injections, Spinal; D008297:Male; D008875:Middle Aged; D009125:Muscle Relaxants, Central / Q000008:administration & dosage*; D009128:Muscle Spasticity / Q000188:drug therapy*; D016459:Prosthesis-Related Infections / Q000188:drug therapy*; D012008:Recurrence; D013119:Spinal Cord Injuries / Q000150:complications*; D013203:Staphylococcal Infections / Q000188:drug therapy*; D017211:Treatment Failure
chemical_list: D000900:Anti-Bacterial Agents; D004343:Drug Implants; D005839:Gentamicins; D009125:Muscle Relaxants, Central; D003094:Collagen; D001418:Baclofen