Mitochondrial myopathy caused by clevudine therapy in chronic hepatitis B patients.
As a pyrimidine analog with potent and sustained antiviral activity against hepatitis B virus, clevudine has been known to have no effect on mitochondrial structure, DNA content, or function. There is little information on the side effects of clevudine, which has not been approved for the treatment of chronic hepatitis B outside of South Korea. We report here two cases of chronic hepatitis B patients who experienced mitochondrial myopathy after clevudine medication. These cases raise concerns about the safety profile of clevudine for the treatment of chronic hepatitis B.
Tak
Won Young
WY
Department of Internal Medicine, Liver Research Institute, Graduate School of Medicine, Kyungpook National University, Daegu, Korea.
Park
Soo Young
SY
Jung
Min Kyu
MK
Jeon
Seong Woo
SW
Cho
Chang Min
CM
Kweon
Young Oh
YO
Kim
Sung Kook
SK
Choi
Yong Hwan
YH