title: Chemical composition and antimicrobial activity of the essential oil of Anaphalis nubigena var. monocephala.
abstract: The essential oil composition of the aerial parts of Anaphalis nubigena DC. var. monocephala (DC.) C. B. Clarke collected from Pindari glacier at a height of 3300 m, was analyzed by using GC and GC/MS. Sixty components were identified, accounting for 95.9% of the total oil. The main constituents were alpha-guaiene (12.3%), gamma-muurolene (10.4%), gamma-cadinene (8.3%), alpha-muurolol (7.4%), alpha-gurjunene (6.0%) and alpha-bulnesene (5.8%). The oil was found to be rich in sesquiterpene hydrocarbons (60.1%). The oil was active against Escherichia coli (NCIM 2065) and Klebsiella pneumoniae (NCIM 2957), with MIC values of 125 microg/mL and 500 microg/mL, respectively.
authors.affiliation: Regional Medical Research Center, Indian Council of Medical Research, Belgaum, Karnataka-590 010, India. joshirk_natprod@yahoo.com
authors.forename: Rajesh K
authors.initials: RK
authors.lastname: Joshi
authors.forename: Chitra
authors.initials: C
authors.lastname: Pande
authors.forename: Mohammad H K
authors.initials: MH
authors.lastname: Mujawar
authors.forename: Sanjiva D
authors.initials: SD
authors.lastname: Kholkute
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D019659:Asteraceae / Q000737:chemistry*; D001419:Bacteria / Q000187:drug effects; D008401:Gas Chromatography-Mass Spectrometry; D008826:Microbial Sensitivity Tests; D009822:Oils, Volatile / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D009822:Oils, Volatile