Four-component domino reaction leading to multifunctionalized quinazolines.
A new four-component domino reaction has been discovered. The reaction is easy to perform simply by mixing four common reactants and K(2)CO(3) in ethylene glycol under microwave irradiation. The reaction proceeds rapidly and can be finished within 10-24 min with water as the major byproduct, making workup convenient. Four stereogenic centers with one quaternary carbon-amino function are controlled very well; the stereochemistry was unequivocally determined by X-ray structural analysis. The resulting pyrido[3,4-i]quinazoline derivatives are of importance for organic and medicinal research.
Jiang
Bo
B
School of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou 221116, Jiangsu, PR China.
Tu
Shu-Jiang
SJ
Kaur
Parminder
P
Wever
Walter
W
Li
Guigen
G
D000447:Aldehydes / Q000737:chemistry; D000577:Amides / Q000737:chemistry; D018360:Crystallography, X-Ray; D055772:Green Chemistry Technology; D007659:Ketones / Q000737:chemistry; D008872:Microwaves; D011799:Quinazolines / Q000737:chemistry*; D013379:Substrate Specificity
D000447:Aldehydes; D000577:Amides; D007659:Ketones; D011799:Quinazolines