Enantioselective conjugate addition employing 2-heteroaryl titanates and zinc reagents.
A general strategy for the conjugate addition of 2-heteroaryl nucleophiles to cyclic enones, unsaturated lactones, and unsaturated lactams in high enantioselectivities and yields is reported. The use of 2-heteroaryl titanates and zinc reagents offers a practical alternative to 2-heteroarylboronic acids, which are prone to undergo protodeboronation.
Smith
Anna J
AJ
Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, Texas 78712, USA.
Abbott
Lily K
LK
Martin
Stephen F
SF
D002384:Catalysis; D003500:Cyclization; D007202:Indicators and Reagents / Q000737:chemistry; D013237:Stereoisomerism; D014025:Titanium / Q000737:chemistry*; D015032:Zinc / Q000737:chemistry*
D007202:Indicators and Reagents; D014025:Titanium; D015032:Zinc