title: Effect of dietary oils on host resistance to fungal infection in psychologically stressed mice.
abstract: Psychological stress can modulate host defense against invading pathogens. In this study, we investigated the effect of dietary oils on social isolation stress-induced modulation of host resistance to Paracoccidioides brasiliensis. In olive oil-fed mice, 3 weeks of isolation stress resulted in temporarily delayed clearance of this fungus in the liver compared with group-housed mice. By contrast, in soybean oil-fed mice, isolation stress had no significant effect on antifungal activity. The olive oil-fed mice showed greater liver interferon (IFN)-gamma and interleukin (IL)-6 production in response to infection as compared with the soybean oil-fed mice. In the olive oil-fed mice, isolation stress led to greater infection-induced IFN-gamma production in the liver compared with the group-housed animals. These results indicate that the modulatory effects of psychological stress on host resistance to P. brasiliensis can vary depending on dietary fatty acid composition.
authors.affiliation: Medical Mycology Research Center, Chiba University, Chiba 260-8673, Japan. motoko.o@faculty.chiba-u.jp
authors.forename: Motoko
authors.initials: M
authors.lastname: Oarada
authors.forename: Miki
authors.initials: M
authors.lastname: Igarashi
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Tsuzuki
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Kurita
authors.forename: Tohru
authors.initials: T
authors.lastname: Gonoi
authors.forename: Takeshi
authors.initials: T
authors.lastname: Nikawa
authors.forename: Katsuya
authors.initials: K
authors.lastname: Hirasaka
authors.forename: Teruo
authors.initials: T
authors.lastname: Miyazawa
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Nakagawa
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Kamei
mesh_terms: D000818:Animals; D004042:Dietary Fats, Unsaturated / Q000494:pharmacology*; D005260:Female; D007371:Interferon-gamma / Q000096:biosynthesis; D015850:Interleukin-6 / Q000096:biosynthesis; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D009181:Mycoses / Q000276:immunology*; D009929:Organ Size / Q000187:drug effects; D012934:Social Isolation; D013154:Spleen / Q000187:drug effects; D013315:Stress, Psychological
chemical_list: D004042:Dietary Fats, Unsaturated; D015850:Interleukin-6; D007371:Interferon-gamma