Mouse models of diabetic nephropathy.
Diabetic nephropathy is a major cause of ESRD worldwide. Despite its prevalence, a lack of reliable animal models that mimic human disease has delayed the identification of specific factors that cause or predict diabetic nephropathy. The Animal Models of Diabetic Complications Consortium (AMDCC) was created in 2001 by the National Institutes of Health to develop and characterize models of diabetic nephropathy and other complications. This interim report and our online supplement detail the progress made toward that goal, specifically in the development and testing of murine models. Updates are provided on validation criteria for early and advanced diabetic nephropathy, phenotyping methods, the effect of background strain on nephropathy, current best models of diabetic nephropathy, negative models, and views of future directions. AMDCC investigators and other investigators in the field have yet to validate a complete murine model of human diabetic kidney disease. Nonetheless, the critical analysis of existing murine models substantially enhances our understanding of this disease process.
Brosius
Frank C
FC
University of Michigan,1150 W. Medical Center Drive, Ann Arbor, MI 48109-0680, USA. fbrosius@umich.edu
Alpers
Charles E
CE
Bottinger
Erwin P
EP
Breyer
Matthew D
MD
Coffman
Thomas M
TM
Gurley
Susan B
SB
Harris
Raymond C
RC
Kakoki
Masao
M
Kretzler
Matthias
M
Leiter
Edward H
EH
Levi
Moshe
M
McIndoe
Richard A
RA
Sharma
Kumar
K
Smithies
Oliver
O
Susztak
Katalin
K
Takahashi
Nobuyuki
N
Takahashi
Takamune
T
D000818:Animals; D058575:Decorin; D003928:Diabetic Nephropathies / Q000209:etiology* / Q000235:genetics / Q000473:pathology; D004195:Disease Models, Animal; D016326:Extracellular Matrix Proteins / Q000172:deficiency; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D052250:Nitric Oxide Synthase Type III / Q000172:deficiency; D010641:Phenotype; D011509:Proteoglycans / Q000172:deficiency; D043782:Receptor, Bradykinin B2 / Q000172:deficiency; D012083:Renin / Q000235:genetics; D013045:Species Specificity
C546878:DCN protein, human; C546879:Dcn protein, mouse; D058575:Decorin; D016326:Extracellular Matrix Proteins; D011509:Proteoglycans; D043782:Receptor, Bradykinin B2; D052250:Nitric Oxide Synthase Type III; C496315:Nos3 protein, mouse; D012083:Renin