The role of steroid receptor coactivator-3 (SRC-3) in human malignant disease.
BACKGROUND
The p160 steroid receptor coactivator (SRC) family is critical to the transcriptional activation function of nuclear hormone receptors. A key member of this family is SRC-3, initially found to be amplified and expressed in breast cancer it has subsequent been shown to be expressed in malignant disease arising from a wide range of other organs. An understanding of the potential role of SRC-3 in the pathogenesis and its possible prognostic role in a broad range of tumours will improve our general understanding of carcinogenesis as well as potentially leading to a new prognostic marker as well as new therapeutic targets.


METHODS
Relevant papers were identified by searching the PubMed and MEDLINE databases for article published until 28th February 2009. Only articles published in English were considered. The search terms included "SRC-3", "AIB1" in association with the following terms: "human", "cancer" and "malignant disease". The search focused on malignant disease arising outside of the mammary gland. Full articles were obtained and references were checked for additional material when appropriate.


RESULTS
SRC-3 is amplified and expressed in a wide spectrum of human malignant diseases and appears to be a potential prognostic marker in a number of different tumours.


CONCLUSIONS
SRC-3 appears to be implicated in the possible risk of developing prostate and ovarian cancer. Its presence appears to be a marker of aggressive disease. Further research is required to determine its predictive and prognostic utility given the relative paucity of studies for each specific malignant disease.
Gojis
O
O
Department of Gynaecology and Obstetrics, Third Faculty of Medicine, Charles University, Ruska 87, Prague 10, 100 00, Czech Republic.
Rudraraju
B
B
Alifrangis
C
C
Krell
J
J
Libalova
P
P
Palmieri
C
C
D000818:Animals; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D018744:DNA, Plant / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D020022:Genetic Predisposition to Disease; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism; D056921:Nuclear Receptor Coactivator 3 / Q000235:genetics* / Q000378:metabolism; D011379:Prognosis; D014158:Transcription, Genetic / Q000235:genetics*
D014408:Biomarkers, Tumor; D018744:DNA, Plant; C538866:NCOA3 protein, human; D056921:Nuclear Receptor Coactivator 3