title: Secoiridoid and iridoid glucosides from the leaves of Fraxinus griffithii.
abstract: Phytochemical investigation of the dried leaves of Fraxinus griffithii collected in Okinawa has led to the isolation of three new secoiridoid glucosides, griffithosides A-C (1-3), and one new iridoid glucoside, 7-epi-7-O-(E)-caffeoylloganic acid (4), along with eight known secoiridoid glucosides (5-12). The structures of these compounds were elucidated by means of NMR, MS, and other spectroscopic techniques, as well as comparison with literature data. The isolated compounds were tested for radical-scavenging activity. Among them, compounds 3, 4, and 7 exhibited substantial radical-scavenging activity.
authors.affiliation: Department of Pharmacognosy, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, Japan.
authors.forename: Rene Angelo
authors.initials: RA
authors.lastname: Macahig
authors.forename: Liva
authors.initials: L
authors.lastname: Harinantenaina
authors.forename: Katsuyoshi
authors.initials: K
authors.lastname: Matsunami
authors.forename: Hideaki
authors.initials: H
authors.lastname: Otsuka
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Takeda
authors.forename: Takakazu
authors.initials: T
authors.lastname: Shinzato
mesh_terms: D031661:Fraxinus / Q000737:chemistry*; D016166:Free Radical Scavengers / Q000302:isolation & purification / Q000494:pharmacology; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D039823:Iridoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018515:Plant Leaves; D013057:Spectrum Analysis / Q000379:methods
chemical_list: D016166:Free Radical Scavengers; D005960:Glucosides; D039823:Iridoids