An update of paediatric intussusception incidence in Singapore: 1997-2007, 11 years of intussusception surveillance.
BACKGROUND
Understanding baseline epidemiology of intussusception (IS) in different geographical settings is important for the safety assessment of rotavirus vaccines. This paper presents IS surveillance data from Singapore between 1997 and 2007, including the period between November 2005 and December 2007 when rotavirus vaccines (primarily Rotarix) were available to newborns in Singapore.


METHODS
Case ascertainment, collection, analyses and presentation of IS data was done as per recommendations of the Brighton Collaboration Working Group. For estimating the IS incidence rate in infants, live births for the years of the study were used as denominators, while for incidence in children age <2 years, the expected numbers of infant deaths occurring between 1 and 2 years of age was deducted from the combined live births for the 2 years, to obtain the denominator.


RESULTS
The incidence of IS among children aged <1 year throughout this 10-year period was higher than the incidence of IS in children between 1 and 2 years of age. In 2005, 2006 and 2007, the incidence of IS per 100,000 was 39.9, 26.4 and 35.6 in children aged <1 year and 26.2, 23.8 and 28.7 in children <2 years.


CONCLUSIONS
This IS surveillance study provides reassuring preliminary evidence that there is no increase in the incidence of IS in Singapore after the introduction of rotavirus vaccines (including Rotarix) in Singapore.
Tan
Nancy
N
Department of Paediatrics, KK Women's and Children's Hospital, Singapore.
Teoh
Yee-Leong
YL
Phua
Kong-Boo
KB
Quak
Seng-Hock
SH
Lee
Bee-Wah
BW
Teo
Harvey James E L
HJ
Jacobsen
Anette
A
Boudville
Irving Charles
IC
Ng
Timothy
T
Verstraeten
Thomas
T
Bock
Hans Ludwig
HL
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D007443:Intussusception / Q000453:epidemiology* / Q000517:prevention & control / Q000821:virology; D008297:Male; D011159:Population Surveillance; D018570:Risk Assessment; D022243:Rotavirus Vaccines; D012846:Singapore / Q000453:epidemiology; D013997:Time Factors
D022243:Rotavirus Vaccines