title: Two-photon fluorescent probes of biological Zn(II) derived from 7-hydroxyquinoline.
abstract: A new fluorescent probe for monitoring Zn(2+) was synthesized based on the structure of 7-hydroxyquinoline. Compared with 8-substituted quinolines, the new probe exhibited higher selectivity for Zn(2+) over Cd(2+). Its fluorescence enhancement (14-fold) and nanomolar range sensitivity (K(d) = 0.117 nM) were favorable toward biological applications. Experiments also showed that a cell-permeable derivative of the new probe was potentially useful for two-photon imaging in living cells.
authors.affiliation: Department of Chemistry, University of Science and Technology of China, Hefei 230026, China.
authors.forename: Xiao-Yun
authors.initials: XY
authors.lastname: Chen
authors.forename: Jing
authors.initials: J
authors.lastname: Shi
authors.forename: Yi-Ming
authors.initials: YM
authors.lastname: Li
authors.forename: Feng-Liang
authors.initials: FL
authors.lastname: Wang
authors.forename: Xu
authors.initials: X
authors.lastname: Wu
authors.forename: Qing-Xiang
authors.initials: QX
authors.lastname: Guo
authors.forename: Lei
authors.initials: L
authors.lastname: Liu
mesh_terms: D045744:Cell Line, Tumor; D018360:Crystallography, X-Ray; D005453:Fluorescence; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry*; D006801:Humans; D006912:Hydroxyquinolines / Q000138:chemical synthesis / Q000737:chemistry*; D008958:Models, Molecular; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D017785:Photons; D015032:Zinc / Q000737:chemistry*
chemical_list: D005456:Fluorescent Dyes; D006912:Hydroxyquinolines; D009942:Organometallic Compounds; D015032:Zinc