title: Efficacy, safety, and tolerability of low-dose hormone therapy in managing menopausal symptoms.
abstract: Use of the lowest clinically effective dose of postmenopausal hormone therapy conforms to current recommendations and good clinical practice. Although accumulating evidence demonstrates the efficacy and tolerability of low hormone therapy doses, data about their use are limited by a lack of long-term, randomized studies. This review evaluates current evidence on the efficacy, safety, and tolerability of these preparations and their role in menopausal management.
authors.affiliation: Outcomes Research Institute, Geisinger Center for Health Research, Danville, PA, USA. rdlanger@jhcpm.com
authors.forename: Robert D
authors.initials: RD
authors.lastname: Langer
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D004361:Drug Tolerance; D064420:Drug-Related Side Effects and Adverse Reactions; D004967:Estrogens / Q000008:administration & dosage; D005260:Female; D020249:Hormone Replacement Therapy; D006801:Humans; D008593:Menopause / Q000187:drug effects* / Q000502:physiology; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D004967:Estrogens