title: [Influence of zinc administered by total parenteral nutrition on plasmatic zinc levels, on reactive C protein, on serum interleukin-6 and on serum interleukin-6 soluble receptor, in critical patients].
abstract: OBJECTIVE
  To study the interrelationship between serum Interleukin-6 (IL-6), serum Interleukin-6 soluble Receptor (IL-6 sR), C-Reactive Protein (C-RP), plasmatic Zinc levels (PlZn) and their response in relation to Zn administered by TPN, in critical patients.
  
  
  METHODS
  17 patients, receiving TPN as a consequence of acute pancreatitis (n = 4) or after a major abdominal surgery due to intestinal cancer (n = 7), intestinal fístula (n = 3), intestinal obstruction (n = 2) or intestinal íleus (n = 1) were studied. At the beginning (To) and at the end of the TPN administration (6-21 days) serum IL-6 and IL-6 sR were determined by ELISA; C-RP ultrasensitive (C-RP us) by inmunoturbidimetric method; Zn was determined in TPN and in plasma by Atomic Absorption Spectrometry. Characteristics of the patients were (mean +/- SD and ranges): age: 60.6 +/- 11.7 (37-77) years; BMI (kg/m(2)): 26.0 +/- 3.4 (19.9-34.0).
  
  
  RESULTS
  The results (mean +/- standard deviation and ranges) were: Zn provided by TPN (mg/d): 6.1 +/- 2.0 (range 2.8 to 10.8). Biochemical levels were, at To and Tf, respectively: (mean+/-SD and ranges) were at To y Tf, respectively: Zn Pl (microg/dl): 104 +/- 46 (35-177); 120 +/- 55 (52-229); IL-6 (pg/mL) 93 +/- 74 (10-262); 117 +/- 180 (7-761); IL6sR (pg/mL): 1,012 +/- 322 (589-1855); 1,269 +/- 451 (631-2195); C-RP us (mg/L): 71 +/- 63 (2-196); 65 +/- 43 (0-137). There was no correlation between variations of IL6, IL6sR, C-RP, PlZn levels and the daily amount of Zn administered in the TPN mixtures. Two patients presented a bad evolution; they received 4.2 and 5.2 md/d of Zn and showed an increase of IL6 levels, maintained high levels of IL6sR but C-RP levels decreased.
  
  
  CONCLUSIONS
  the range of 2.8 to 10.8 mg/d of Zn administered in TPN mixtures did not exacerbate the inflammatory response.
authors.affiliation: Instituto Argentino de Educación e Investigación en Nutrición, Buenos Aires, Argentina.
authors.forename: A M
authors.initials: AM
authors.lastname: Menéndez
authors.forename: M L
authors.initials: ML
authors.lastname: De Portela
authors.forename: A
authors.initials: A
authors.lastname: Weisstaub
authors.forename: H
authors.initials: H
authors.lastname: Montemerlo
authors.forename: M E
authors.initials: ME
authors.lastname: Guidoni
authors.forename: F
authors.initials: F
authors.lastname: Rusí
authors.forename: S
authors.initials: S
authors.lastname: Zeni
mesh_terms: D000328:Adult; D000368:Aged; D002097:C-Reactive Protein / Q000032:analysis*; D016638:Critical Illness; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010289:Parenteral Nutrition, Total; D019947:Receptors, Interleukin-6 / Q000097:blood*; D015032:Zinc / Q000097:blood* / Q000494:pharmacology*
chemical_list: D015850:Interleukin-6; D019947:Receptors, Interleukin-6; D002097:C-Reactive Protein; D015032:Zinc