Banana peel extract suppressed prostate gland enlargement in testosterone-treated mice.
A methanol extract of banana peel (BPEx, 200 mg/kg, p.o.) significantly suppressed the regrowth of ventral prostates and seminal vesicles induced by testosterone in castrated mice. Further studies in the androgen-responsive LNCaP human prostate cancer cell line showed that BPEx inhibited dose-dependently testosterone-induced cell growth, while the inhibitory activities of BPEx did not appear against dehydrotestosterone-induced cell growth. These results indicate that methanol extract of banana peel can inhibit 5alpha-reductase and might be useful in the treatment of benign prostate hyperplasia.
Akamine
Kiichiro
K
Laboratory of Nutraceuticals and Functional Foods Science, Graduate School of Marine Science and Technology, Tokyo University of Marine Science and Technology, 4-5-7 Konan, Minato-ku, Tokyo 108-8477, Japan.
Koyama
Tomoyuki
T
Yazawa
Kazunaga
K
D000818:Animals; D045744:Cell Line, Tumor; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008297:Male; D051379:Mice; D028521:Musa / Q000737:chemistry*; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D011467:Prostate / Q000187:drug effects / Q000254:growth & development; D011470:Prostatic Hyperplasia / Q000517:prevention & control*; D012669:Seminal Vesicles / Q000187:drug effects / Q000254:growth & development; D013739:Testosterone / Q000009:adverse effects*
D010936:Plant Extracts; D013739:Testosterone