Photo-polymeriable chitosan derivative prepared by Michael reaction of chitosan and polyethylene glycol diacrylate (PEGDA).
N-Alkyled photo-polymeriable chitosan derivative (PEGDA-CS) was synthesized by Michael reaction of chitosan and polyethylene glycol diacrylate (PEGDA) under mild reaction conditions. The chemical structure and physical properties of PEGDA-CS were characterized by FT-IR, (1)H NMR, XRD and TG techniques. The degree of substitution (DS) of PEGDA-CS could be calculated from (1)H NMR. PEGDA-CS exhibited good solubility in distilled water. XRD analysis showed that PEGDA-CS was amorphous. TG results demonstrated that thermal stability of the derivate was lower than that of chitosan. Antimicrobial test showed that PEGDA-CS had the antimicrobial activity on Escherichia coli. It could photopolymerize under ultraviolet light with 2959 as initiator.
Ma
Guiping
G
State Key Laboratory of Chemical Resource Engineering, College of Materials Science and Engineering, Beijing University of Chemical Technology, 15 Beisanhuan East Road, Chaoyang, Beijing 100029, PR China.
Zhang
Xiaodan
X
Han
Jing
J
Song
Guoqiang
G
Nie
Jun
J
D000890:Anti-Infective Agents / Q000494:pharmacology; D002625:Chemistry, Organic / Q000379:methods; D048271:Chitosan / Q000737:chemistry*; D004926:Escherichia coli / Q000378:metabolism; D008027:Light; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008956:Models, Chemical; D011092:Polyethylene Glycols / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods; D013818:Thermogravimetry / Q000379:methods; D014466:Ultraviolet Rays; D014867:Water / Q000737:chemistry; D014961:X-Ray Diffraction
D000890:Anti-Infective Agents; D011108:Polymers; C437167:poly(ethylene glycol)diacrylate; D014867:Water; D011092:Polyethylene Glycols; D048271:Chitosan