Aurora A moonlights in neurite extension.
Aurora A, an integral mitotic kinase, is essential for microtubule dynamics of post-mitotic neurons. PKCzeta activates Aurora A, which in turn phosphorylates NDEL1 to promote neurite extension. This raises the possibility that Aurora A may also be involved in establishing cell polarity and axon/dendrite elaboration in young neurons.
Lefkowitz
Gloria Kuo
GK
Gleeson
Joseph G
JG
D000818:Animals; D064096:Aurora Kinase A; D064127:Aurora Kinases; D002352:Carrier Proteins / Q000378:metabolism; D051379:Mice; D008870:Microtubules / Q000201:enzymology; D008954:Models, Biological; D016501:Neurites / Q000201:enzymology*; D010769:Phosphothreonine / Q000378:metabolism; D011493:Protein Kinase C / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D015398:Signal Transduction
D002352:Carrier Proteins; C486015:Ndel1 protein, mouse; D010769:Phosphothreonine; C576918:Aurka protein, mouse; D064096:Aurora Kinase A; D064127:Aurora Kinases; D017346:Protein Serine-Threonine Kinases; C115015:PKC-3 protein; D011493:Protein Kinase C