Copper nitrate catalyzed three-component one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones.
An efficient synthesis of 3,4-dihydropyrimidin-2(1H)-ones from aldehydes, 1,3-dicarbonyl compounds, and urea using copper nitrate under refluxing temperature in ethanol was described. Compared with other Lewis copper salts, copper nitrate proved to be the most efficient. The advantages of the new method were good yields (61-93%), short reaction time (0.4-3 h), and inexpensive catalyst.
Wang
Min
M
College of Chemistry and Chemical Engineering, Bohai University, Jinzhou, Liaoning, P. R. China. minwangszg@yahoo.com.cn
Jiang
Heng
H
Song
Zhiguo
Z
Gong
Hong
H
D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D009566:Nitrates / Q000737:chemistry*; D011744:Pyrimidinones / Q000138:chemical synthesis*; D014508:Urea / Q000737:chemistry*
D000447:Aldehydes; D009566:Nitrates; D011744:Pyrimidinones; D003300:Copper; D014508:Urea