title: Stereoselective synthesis of highly functionalized structures from lactate-derived halo ketones.
abstract: Highly diastereoselective (i-PrO)(2)TiCl(2)-mediated aldol reactions from lactate-derived alpha'-halo alpha-silyloxy ketones and subsequent treatment of the resultant aldols with a wide range of nucleophiles furnishes highly functionalized arrangements useful in natural product syntheses.
authors.affiliation: Departament de Química Orgànica, Universitat de Barcelona, Catalonia, Spain.
authors.forename: Joaquim
authors.initials: J
authors.lastname: Nebot
authors.forename: Pedro
authors.initials: P
authors.lastname: Romea
authors.forename: Fèlix
authors.initials: F
authors.lastname: Urpí
mesh_terms: D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D019344:Lactic Acid / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D007659:Ketones; D019344:Lactic Acid