[The mucoadhesion phenomena and importance in drug application].
The main assignment of the pharmaceutical sciences is to develop new, safer and more effective methods of pharmacotherapy. Among tools used to realize this goal are modern drug formulations, both for new and well known active substances. Different concepts have been proposed to achieve efficient drug delivery, and mucoadhesion has received a significant degree of attention during past years. Mucoadhesive systems, thanks to the presence of certain polymers, may attach for few hours to the mucosal membrane and therefore it is possible to obtain prolonged, local or systemic drug effect. This article contains an overview of data concerning the mucoadhesion phenomena and most important adhesion theories. Furthermore, methods that are frequently used to study the adhesion forces between drug and mucus as well as application of mucoadhesive hydrogels as drug carriers for different mucosal membranes are also discussed.
Płaczek
Marcin
M
Katedra i Zakład Farmacji Stosowanej Gdański Uniwersytet Medyczny. mpl@amg.gda.pl
Sznitowska
Małgorzata
M
D000268:Adhesiveness; D000278:Administration, Buccal; D002626:Chemistry, Pharmaceutical; D020100:Hydrogels / Q000008:administration & dosage / Q000737:chemistry* / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D008954:Models, Biological; D008970:Molecular Weight; D009092:Mucous Membrane / Q000378:metabolism*; D004364:Pharmaceutical Preparations; D011108:Polymers / Q000008:administration & dosage / Q000737:chemistry*
D020100:Hydrogels; D004364:Pharmaceutical Preparations; D011108:Polymers