Effect of captopril on pulmonary artery pressure following corrective surgery for tetralogy of fallot.
BACKGROUND
This study was designed to investigate the effect of captopril on systolic pulmonary arterial pressure (PAP) and circulating endothelin-1 (ET-1) following surgical repair of tetralogy of Fallot (TOF).


RESULTS
Seventy-six consecutive patients were divided into captopril and control groups following successful repair of TOF. The captopril group was treated with oral captopril (0.2 mg/kg/day) for 12 months. Venous blood was taken before and after the surgery for the analysis of ET-1. Systolic PAP and ventricular function were assessed by Doppler echocardiography. In the control group, there was an increase in ET-1 and systolic PAP following the surgery (p < 0.05). In the captopril group, there was no significant increase in the systolic PAP and ET-1 during the 12-month follow-up. The PAP and ET-1 values in the captopril group were lower than those in the control group following the surgery (p < 0.05).


CONCLUSIONS
Systolic PAP is elevated following the complete surgical repair of TOF. Increased circulating ET-1 may be responsible for the elevation of PAP. Captopril treatment prevents postsurgical increases in systolic PAP and circulating ET-1.
Ma
Zeng-Shan
ZS
Department of Cardiac Surgery, Liaocheng People's Hospital and Liaocheng Clinical School of Taishan Medical University, Liaocheng, Shandong 252000, People's Republic of China.
Ma
Sheng-Jun
SJ
Dong
Ming-Feng
MF
Wang
Jian-Tang
JT
Wang
Le-Xin
LX
D000293:Adolescent; D000328:Adult; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects*; D002216:Captopril / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D019332:Endothelin-1 / Q000097:blood / Q000187:drug effects*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D011184:Postoperative Period; D011651:Pulmonary Artery / Q000000981:diagnostic imaging / Q000187:drug effects*; D013599:Systole; D013771:Tetralogy of Fallot / Q000601:surgery*; D013997:Time Factors; D018615:Ultrasonography, Doppler, Color; D055815:Young Adult
D000806:Angiotensin-Converting Enzyme Inhibitors; D019332:Endothelin-1; D002216:Captopril