title: A powerful reagent for synthesis of Weinreb amides directly from carboxylic acids.
abstract: A powerful reagent, P[NCH(3)(OCH(3))](3) (3), for conversion of carboxylic acids directly to Weinreb amides was developed. In most cases the yields of the corresponding Weinreb amides were above 90% when P[NCH(3)(OCH(3))](3) was heated with aromatic and aliphatic carboxylic acids in toluene. The sterically hindered carboxylic acids can also give the corresponding Weinreb amides in excellent yields.
authors.affiliation: College of Chemistry and Chemical Engineering, Northwest Normal University, 967 Anning Road (E.), Lanzhou 730070, PR China.
authors.forename: Teng
authors.initials: T
authors.lastname: Niu
authors.forename: Weiming
authors.initials: W
authors.lastname: Zhang
authors.forename: Danfeng
authors.initials: D
authors.lastname: Huang
authors.forename: Changming
authors.initials: C
authors.lastname: Xu
authors.forename: Haifeng
authors.initials: H
authors.lastname: Wang
authors.forename: Yulai
authors.initials: Y
authors.lastname: Hu
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D002264:Carboxylic Acids / Q000737:chemistry*; D015394:Molecular Structure; D009943:Organophosphorus Compounds / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000577:Amides; D002264:Carboxylic Acids; D009943:Organophosphorus Compounds; C545157:P(NCH3(OCH3))3