title: An expedient route to a potent gastrin/CCK-B receptor antagonist (+)-AG-041R.
abstract: An enantiocontrolled synthesis of (+)-AG-041R (1), a potent gastrin/CCK-B receptor antagonist, has been achieved employing a chiral rhodium(II)-catalyzed, oxidative intramolecular aza-spiroannulation as the key step.
authors.affiliation: Graduate school of Pharmaceutical sciences, Tohoku University, 6-3 Aobayama, Sendai 980-8578, Japan.
authors.forename: Shigeki
authors.initials: S
authors.lastname: Sato
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Shibuya
authors.forename: Naoki
authors.initials: N
authors.lastname: Kanoh
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Iwabuchi
mesh_terms: D002384:Catalysis; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D043887:Receptor, Cholecystokinin B / Q000037:antagonists & inhibitors; D012238:Rhodium / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: C109755:AG-041R; D007211:Indoles; D043887:Receptor, Cholecystokinin B; D012238:Rhodium