[Functions of eosinophil granulocytes: from anti-parasite immunity to anti-tumoral potential].
Eosinophils have long been considered simply as effectors of adaptive immune responses during parasitic infections and inflammatory processes. Their role in allergic manifestations and mucosal responses is mediated by membrane receptors that allow them to interact with IgE and IgA antibodies. The recent demonstration that human eosinophils express innate immune receptors suggests that they may also play a role in antitumoral immune surveillance. Experimental evidence shows that human eosinophils have tumoricidal potential, in synergy with other effector cells, notably by releasing cytotoxic molecules.
Capron
Monique
M
U Inserm U547, Université Lille 2, Institut Pasteur, rue du Professeur Calmette, 59800 Lille.
Legrand
Fanny
F
D004804:Eosinophils / Q000502:physiology*; D006801:Humans; D009369:Neoplasms / Q000276:immunology*; D010272:Parasitic Diseases / Q000276:immunology*