title: Ferumoxytol for treatment of iron deficiency anemia in patients with chronic kidney disease.
abstract: BACKGROUND
  Iron deficiency anemia (IDA) is a common problem in patients with chronic kidney disease (CKD). Use of intravenous (i.v.) iron effectively treats the resultant anemia, but available iron products have side effects or dosing regimens that limit safety and convenience.
  
  
  OBJECTIVE
  Ferumoxytol (Feraheme) is a new i.v. iron product recently approved for use in treatment of IDA in CKD patients. This article reviews the structure, pharmacokinetics, and clinical trial results on ferumoxytol. The author also offers his opinions on the role of this product in clinical practice.
  
  
  METHODS
  This review encompasses important information contained in clinical and preclinical studies of ferumoxytol and is supplemented with information from the US Food and Drug Administration.
  
  
  CONCLUSIONS
  Ferumoxytol offers substantial safety and superior efficacy compared with oral iron therapy. As ferumoxytol can be administered as 510 mg in < 1 min, it is substantially more convenient than other iron products in nondialysis patients. Although further experience with this product is needed in patients at higher risk of drug reactions, ferumoxytol is likely to be highly useful in the hospital and outpatient settings for treatment of IDA.
authors.affiliation: Washington University School of Medicine, St Louis, MO 63110, USA. DCoyne@im.wustl.edu
authors.forename: Daniel W
authors.initials: DW
authors.lastname: Coyne
mesh_terms: D018798:Anemia, Iron-Deficiency / Q000188:drug therapy* / Q000209:etiology; D000818:Animals; D002986:Clinical Trials as Topic; D004353:Drug Evaluation, Preclinical; D052203:Ferrosoferric Oxide / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D007275:Injections, Intravenous; D051436:Renal Insufficiency, Chronic / Q000150:complications*
chemical_list: D052203:Ferrosoferric Oxide