title: An update of paediatric intussusception incidence in Singapore: 1997-2007, 11 years of intussusception surveillance.
abstract: BACKGROUND
  Understanding baseline epidemiology of intussusception (IS) in different geographical settings is important for the safety assessment of rotavirus vaccines. This paper presents IS surveillance data from Singapore between 1997 and 2007, including the period between November 2005 and December 2007 when rotavirus vaccines (primarily Rotarix) were available to newborns in Singapore.
  
  
  METHODS
  Case ascertainment, collection, analyses and presentation of IS data was done as per recommendations of the Brighton Collaboration Working Group. For estimating the IS incidence rate in infants, live births for the years of the study were used as denominators, while for incidence in children age <2 years, the expected numbers of infant deaths occurring between 1 and 2 years of age was deducted from the combined live births for the 2 years, to obtain the denominator.
  
  
  RESULTS
  The incidence of IS among children aged <1 year throughout this 10-year period was higher than the incidence of IS in children between 1 and 2 years of age. In 2005, 2006 and 2007, the incidence of IS per 100,000 was 39.9, 26.4 and 35.6 in children aged <1 year and 26.2, 23.8 and 28.7 in children <2 years.
  
  
  CONCLUSIONS
  This IS surveillance study provides reassuring preliminary evidence that there is no increase in the incidence of IS in Singapore after the introduction of rotavirus vaccines (including Rotarix) in Singapore.
authors.affiliation: Department of Paediatrics, KK Women's and Children's Hospital, Singapore.
authors.forename: Nancy
authors.initials: N
authors.lastname: Tan
authors.forename: Yee-Leong
authors.initials: YL
authors.lastname: Teoh
authors.forename: Kong-Boo
authors.initials: KB
authors.lastname: Phua
authors.forename: Seng-Hock
authors.initials: SH
authors.lastname: Quak
authors.forename: Bee-Wah
authors.initials: BW
authors.lastname: Lee
authors.forename: Harvey James E L
authors.initials: HJ
authors.lastname: Teo
authors.forename: Anette
authors.initials: A
authors.lastname: Jacobsen
authors.forename: Irving Charles
authors.initials: IC
authors.lastname: Boudville
authors.forename: Timothy
authors.initials: T
authors.lastname: Ng
authors.forename: Thomas
authors.initials: T
authors.lastname: Verstraeten
authors.forename: Hans Ludwig
authors.initials: HL
authors.lastname: Bock
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D007443:Intussusception / Q000453:epidemiology* / Q000517:prevention & control / Q000821:virology; D008297:Male; D011159:Population Surveillance; D018570:Risk Assessment; D022243:Rotavirus Vaccines; D012846:Singapore / Q000453:epidemiology; D013997:Time Factors
chemical_list: D022243:Rotavirus Vaccines