Anti-oxidative effects of Phellinus linteus and red ginseng extracts on oxidative stress-induced DNA damage.
Anti-oxidative effect of Phellinus linteus (P. linteus) and red ginseng extracts on DNA damage induced by reactive oxygen species (ROS) were investigated in this study. P. linteus (PLE) and red ginseng extracts (RGE) inhibited the breaking of E. coli ColE1 plasmid DNA strands as well as nuclear DNA of rat hepatocytes damaged by oxidative stress. In addition, a reaction mixture of PLE and RGE showed synergistic inhibitory effect against DNA damage. These results suggest that PLE and RGE have a cellular defensive effect against DNA damage induced by ROS.
Park
Byung-Jae
BJ
Department of Life Science, Hallym University, Chunchon 202-702, Korea.
Lim
Yeong-Seok
YS
Lee
Hee-Jung
HJ
Eum
Won Sik
WS
Park
Jinseu
J
Han
Kyu Hyung
KH
Choi
Soo Young
SY
Lee
Kil Soo
KS
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002467:Cell Nucleus / Q000187:drug effects / Q000378:metabolism; D053960:DNA Breaks / Q000187:drug effects; D004249:DNA Damage; D004269:DNA, Bacterial / Q000378:metabolism; D005057:Eukaryotic Cells / Q000187:drug effects / Q000378:metabolism; D005296:Ferrous Compounds / Q000494:pharmacology; D022781:Hepatocytes / Q000187:drug effects / Q000378:metabolism; D006861:Hydrogen Peroxide / Q000494:pharmacology; D018384:Oxidative Stress / Q000187:drug effects*; D005894:Panax / Q000378:metabolism*; D000084682:Phellinus; D010936:Plant Extracts / Q000494:pharmacology*; D010957:Plasmids / Q000378:metabolism; D011134:Polysaccharides / Q000494:pharmacology*; D051381:Rats
D000975:Antioxidants; D004269:DNA, Bacterial; D005296:Ferrous Compounds; C526145:Phellinus linteus extract; D010936:Plant Extracts; D011134:Polysaccharides; D006861:Hydrogen Peroxide; C029451:ferrous chloride