Comparison of anti-inflammatory activity of dexamethasone and diclofenac sodium eye drops in phacoemulsification.
OBJECTIVE
To compare the effectiveness of dexamethasone and diclofenac sodium eye drops in the resolution of inflammation following phacoemulsification surgery with posterior chamber intraocular lens implants.


METHODS
Quasi-experimental study.


METHODS
Ophthalmology Department, PNS Shifa Hospital, Karachi, from June 2006 to March 2007.


METHODS
One hundred subjects were operated and postoperatively divided into two groups, designated as 'dexamethasone' and 'diclofenac' groups. They were assessed for visual acuity and followed for 5 weeks for the signs of inflammation, which included cells and flare in the anterior chamber and striate keratopathy. Proportions were compared by Fisher's exact test and the chi-square test.


RESULTS
Topically applied diclofenac sodium suppressed postoperative inflammation effectively but its anti-inflammatory effects were of lesser magnitude as compared to that of topically applied dexamethasone drops (p < 0.005).


CONCLUSIONS
Dexamethasone eye drops were found to have more potent anti-inflammatory activity in moderate to severe cases than diclofenac sodium eye drops in postoperative cases.
Waseem
Muhammad
M
Department of Opthalmology, PNS Shifa Hospital, Karachi. mwkhan@brain.net.pk
Humayun
Sadia
S
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D003907:Dexamethasone / Q000627:therapeutic use*; D004008:Diclofenac / Q000627:therapeutic use*; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D007249:Inflammation / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions; D010149:Postoperative Pain / Q000188:drug therapy*; D018918:Phacoemulsification; D014787:Vision Tests; D014792:Visual Acuity
D000894:Anti-Inflammatory Agents, Non-Steroidal; D005938:Glucocorticoids; D009883:Ophthalmic Solutions; D004008:Diclofenac; D003907:Dexamethasone