The fabrication of uniform cylindrical nanoshells and their use as spectrally tunable MRI contrast agents.
A new form of tunable magnetic resonance imaging agent based on precisely dimensioned cylindrical magnetic nanoshells is introduced. Using top-down prepatterned substrates, the nanoshells are fabricated by exploiting what is usually regarded as a detrimental processing side-effect, namely the redeposition of material back-sputtered during ion-milling. The well-resolved nuclear magnetic resonance peaks of the resulting nanostructures attest to the nanoscale fabrication control and the general feasibility of such sputter redeposition for fabrication of a variety of self-supporting, highly monodisperse nanoscale structures.
Zabow
G
G
Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA. zabow@boulder.nist.gov
Dodd
S J
SJ
Moreland
J
J
Koretsky
A P
AP
D003287:Contrast Media / Q000737:chemistry*; D006046:Gold; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008855:Microscopy, Electron, Scanning; D049329:Nanostructures / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D019047:Phantoms, Imaging; D014025:Titanium
D003287:Contrast Media; D006046:Gold; D014025:Titanium