Pd-catalyzed conversion of aryl chlorides, triflates, and nonaflates to nitroaromatics.
An efficient Pd catalyst for the transformation of aryl chlorides, triflates, and nonaflates to nitroaromatics has been developed. This reaction proceeds under weakly basic conditions and displays a broad scope and excellent functional group compatibility. Moreover, this method allows for the synthesis of aromatic nitro compounds that cannot be accessed efficiently via other nitration protocols. Mechanistic insight into the transmetalation step of the catalytic process is also reported.
Fors
Brett P
BP
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Buchwald
Stephen L
SL
D002384:Catalysis; D002712:Chlorides / Q000737:chemistry*; D006841:Hydrocarbons, Aromatic / Q000737:chemistry*; D008698:Mesylates / Q000737:chemistry*; D009584:Nitrogen / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
D002712:Chlorides; D006841:Hydrocarbons, Aromatic; D008698:Mesylates; D010165:Palladium; C012077:trifluoromethanesulfonic acid; D009584:Nitrogen