Copper-catalyzed cascade addition/cyclization: an efficient and versatile synthesis of N-substituted 2-heterobenzimidazoles.
A novel and efficient one-pot synthesis of various N-substituted 2-heterobenzimidazoles has been developed. Through a Cu(I)-catalyzed cascade intermolecular addition/intramolecular C-N coupling process, a wide variety of 2-heterobenzimidazoles could be synthesized from o-haloarylcarbodiimides and N- or O-nucleophiles.
Lv
Xin
X
Department of Chemistry, Xixi Campus, Zhejiang University, Hangzhou 310028, People's Republic of China.
Bao
Weiliang
W
D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D015394:Molecular Structure; D013237:Stereoisomerism
D001562:Benzimidazoles; D003300:Copper