title: Clinical and biological relationship between chronic lymphocytic thyroiditis and papillary thyroid carcinoma.
abstract: The association between chronic lymphocytic thyroiditis and papillary thyroid carcinoma has been investigated for several years from different perspectives but with few attempts to design a common frame of reference to understand the complex mutual interactions between the various pathways of inflammatory response and of thyroid tumor induction and progression. This article reviews the current knowledge and research on this topic according to epidemiologic, immunobiologic, pathologic, and biomolecular points of view, highlighting achievements and lack of knowledge. It draws some conclusions and points at possible future directions for research.
authors.affiliation: Department of Surgery Francesco Durante, University Sapienza of Rome, Rome, Italy.
authors.forename: Alfredo
authors.initials: A
authors.lastname: Antonaci
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Consorti
authors.forename: Stefania
authors.initials: S
authors.lastname: Mardente
authors.forename: Gloria
authors.initials: G
authors.lastname: Giovannone
mesh_terms: D002291:Carcinoma, Papillary / Q000150:complications* / Q000473:pathology; D050031:Hashimoto Disease / Q000150:complications* / Q000473:pathology; D006801:Humans; D013964:Thyroid Neoplasms / Q000150:complications* / Q000473:pathology