title: Systolic heart failure: a prothrombotic state.
abstract: Systolic heart failure is a common syndrome whose incidence is expected to increase. Several treatment modalities, such as beta-blockers and angiotensin-converting enzyme inhibitors, improve survival. Whether antithrombotic treatment is effective remains to be elucidated, although observations suggest a prothrombotic state in heart failure. This article focuses on this prothrombotic state and discusses the risk of thromboembolic events, pathophysiological mechanisms, and the potential role of anticoagulant treatment.
authors.affiliation: Department of Vascular Medicine, Academic Medical Centre, University of Amsterdam, 1100 DD Amsterdam, The Netherlands. O.R.dePeuter@amc.uva.nl
authors.forename: Olav R
authors.initials: OR
authors.lastname: de Peuter
authors.forename: Wouter E M
authors.initials: WE
authors.lastname: Kok
authors.forename: Christian
authors.initials: C
authors.lastname: Torp-Pedersen
authors.forename: Harry R
authors.initials: HR
authors.lastname: Büller
authors.forename: Pieter W
authors.initials: PW
authors.lastname: Kamphuisen
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D057911:Angiotensin Receptor Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D000925:Anticoagulants / Q000627:therapeutic use*; D001241:Aspirin / Q000627:therapeutic use; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D054143:Heart Failure, Systolic / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans; D009203:Myocardial Infarction / Q000209:etiology; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D011379:Prognosis; D011655:Pulmonary Embolism / Q000209:etiology; D016032:Randomized Controlled Trials as Topic; D012084:Renin-Angiotensin System / Q000187:drug effects; D013923:Thromboembolism / Q000209:etiology; D014859:Warfarin / Q000627:therapeutic use
chemical_list: D000319:Adrenergic beta-Antagonists; D057911:Angiotensin Receptor Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D000925:Anticoagulants; D005343:Fibrinolytic Agents; D010975:Platelet Aggregation Inhibitors; D014859:Warfarin; D001241:Aspirin