title: [Species composition of anaerobic microflora in parodontal pocket depending upon disease stage].
abstract: With the help of polymerase chain reaction (PCR) the dynamic of species composition of anaerobic microflora in cases of generalized parodontitis was established. It was detected that disease severity increase was followed by the increase of the number of anaerobic microflora species in parodontal pocket; at that it was impossible to connect the presence of some determined type of microorganism with the inflammatory parodontal process intensity. It was shown that proteins fimbrilin and gingipain were not the only parodontitis pathogenic factors although the first one (fimbrilin) could be connected with aggressive disease flow. The suggested PCR scheme could be useful for early disease stage diagnostic and substantiation of antimicrobial therapy method selection.
authors.forename: N V
authors.initials: NV
authors.lastname: Zyrianova
authors.forename: A S
authors.initials: AS
authors.lastname: Grigor'ian
authors.forename: A I
authors.initials: AI
authors.lastname: Grudianov
authors.forename: O A
authors.initials: OA
authors.lastname: Frolova
authors.forename: I I
authors.initials: II
authors.lastname: Shil'nikova
authors.forename: M I
authors.initials: MI
authors.lastname: Kobozev
mesh_terms: D001421:Bacteria, Anaerobic / Q000302:isolation & purification*; D018450:Disease Progression; D010861:Fimbriae, Bacterial; D006801:Humans; D010514:Periodontal Pocket / Q000382:microbiology*; D010518:Periodontitis / Q000175:diagnosis / Q000382:microbiology* / Q000628:therapy; D019105:Random Amplified Polymorphic DNA Technique; D012720:Severity of Illness Index; D013997:Time Factors