title: Clinical features and epidemiology of chikungunya infection in Singapore.
abstract: Chikungunya is a re-emerging mosquito-borne viral infection that has spread from East Africa to Indian Ocean islands and re-emerged in India since 2004. In Malaysia, chikungunya re-emerged after a hiatus of seven years, causing a localised outbreak in a north-western coastal town in 2006 and subsequently widespread outbreaks in 2008. Since the first local outbreak of chikungunya in Singapore in January 2008, chikungunya infections have been increasingly reported in Singapore. In this case series, five patients aged 37-62 years, with chikungunya infection confirmed in August 2008, were reported. Three of the five were male, and only one had medical comorbidities. Two had a travel history to Johor, Malaysia, where local outbreaks of chikungunya had been reported. Fever, arthralgia and rash were the most common symptoms. Fever lasted four to five days while viraemia lasted four to 11 days, persisting two to three days after defervescence in three patients. A biphasic pattern of fever was observed in two patients. Leucopenia was noted in all patients, while mild thrombocytopenia and transaminitis occurred in three of five patients. Two patients had persistent polyarthralgia at two to three weeks after the onset of symptoms. Fever, arthralgia and rash should prompt consideration of acute chikungunya in Singapore. While taking the travel history, doctors should be mindful that indigenous chikungunya cases can occur.
authors.affiliation: Department of Infectious Diseases, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore.
authors.forename: K W
authors.initials: KW
authors.lastname: Ng
authors.forename: A
authors.initials: A
authors.lastname: Chow
authors.forename: M K
authors.initials: MK
authors.lastname: Win
authors.forename: F
authors.initials: F
authors.lastname: Dimatatac
authors.forename: H Y
authors.initials: HY
authors.lastname: Neo
authors.forename: D C
authors.initials: DC
authors.lastname: Lye
authors.forename: Y S
authors.initials: YS
authors.lastname: Leo
mesh_terms: D000328:Adult; D000524:Alphavirus / Q000378:metabolism*; D018354:Alphavirus Infections / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy; D000818:Animals; D009033:Culicidae; D004196:Disease Outbreaks; D005260:Female; D006801:Humans; D008296:Malaysia; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012846:Singapore; D013997:Time Factors; D016896:Treatment Outcome