Effects of plasma rich in growth factors on wound healing of the tongue. Experimental study on rabbits.
OBJECTIVE
To apply autologous Plasma Rich in Growth Factors (PRGF) in wounds provoked in the tongue of New Zealand albino rabbits and to study its effects in the epithelialization and inflammation of the wounds at 7 and 28 days after its application.


METHODS
A prospective study carried out on 20 adult rabbits. Two wounds were made on the midline of the dorsal surface of the tongue in each animal, one control, and the other in which PRGF was applied. A histological study of the epithelialization and inflammation of wounds at 7 and 28 days was made.


RESULTS
At 7 days were not observed differences between the study group and the control, nevertheless at 28 days all the wounds in which we applied the PRGF were completely epithelialized and with resolution of the inflammatory process, finding significant differences with respect to the control (p=0.031) and (p=0.023).


CONCLUSIONS
The PRGF accelerates epithelialization and reduces inflammation at 28 days of provoking wounds in the oral mucosa.
López-Jornet
Pía
P
Department of Oral Medicine, Faculty of Medicine and Dentistry, University of Murcia, Spain.
Camacho-Alonso
Fabio
F
Molina-Miñano
Francisco
F
Vicente-Ortega
Vicente
V
D000818:Animals; D036341:Intercellular Signaling Peptides and Proteins / Q000627:therapeutic use*; D008297:Male; D010949:Plasma; D011817:Rabbits; D014945:Wound Healing / Q000187:drug effects*
D036341:Intercellular Signaling Peptides and Proteins