title: Endothelium and vascular smooth muscle cells in the context of uremia.
abstract: It is obvious that retention of uremic toxins leads to endothelial dysfunction, which in turn initiates proliferation of vascular smooth muscle cells. Yet, the entity of the cascade of pathomechanisms has not sufficiently been elucidated. Endothelial dysfunction inevitably and irreversibly leads to progressive cardiovascular dysfunction and thereby represents the beginning of a life-limiting cascade. This review highlights important findings in this field.
authors.affiliation: Charité-Universitätsmedizin Berlin, Medizinische Klinik IV (CBF), Berlin, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Günthner
authors.forename: Vera
authors.initials: V
authors.lastname: Jankowski
authors.forename: Axel
authors.initials: A
authors.lastname: Kretschmer
authors.forename: Marc
authors.initials: M
authors.lastname: Nierhaus
authors.forename: Markus
authors.initials: M
authors.lastname: van der Giet
authors.forename: Walter
authors.initials: W
authors.lastname: Zidek
authors.forename: Joachim
authors.initials: J
authors.lastname: Jankowski
mesh_terms: D050197:Atherosclerosis / Q000150:complications / Q000473:pathology; D004730:Endothelium, Vascular / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D009131:Muscle, Smooth, Vascular / Q000473:pathology* / Q000503:physiopathology; D032389:Myocytes, Smooth Muscle / Q000473:pathology* / Q000502:physiology; D014511:Uremia / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology