Pluripotent stem cells and disease modeling.
Human embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs) can theoretically be converted into any somatic cell type. hESCs and hiPSCs carrying genetic defects can now be produced to model diseases in vitro. We suggest several guiding principles to help ensure an optimal fit between technology and disease.
Colman
Alan
A
Institute of Medical Biology, Singapore, Singapore. alan.colman@imb.a-star.edu.sg
Dreesen
Oliver
O
D000818:Animals; D004194:Disease; D004195:Disease Models, Animal; D053595:Embryonic Stem Cells / Q000166:cytology; D006801:Humans; D008954:Models, Biological; D039904:Pluripotent Stem Cells / Q000166:cytology*