Clinical profile of patients with nonarteritic anterior ischemic optic neuropathy presented to a referral center from 2003 to 2008.
BACKGROUND
We conducted this study to report the demographics and clinical profile of patients with nonarteritic anterior ischemic optic neuropathy referred to a referral neuro-ophthalmology center in Iran.


METHODS
During a five-year period, 107 patients with nonarteritic anterior ischemic optic neuropathy were studied. A detailed history of previous or current systemic diseases was obtained and a complete ophthalmic evaluation including best corrected visual acuity, color vision testing, and computerized perimetry was performed.


RESULTS
Sixty-six men and 41 women with a mean+/-SD age of 52.7+/-10.3 (range: 30 - 80) years were studied. Most (62.2%) of the patients aged more than 50 years. Twenty-two (20.5%) patients had had an episode of nonarteritic anterior ischemic optic neuropathy in the fellow eye. Overall, 51 (47.7%) patients had no evidence of a previous or current systemic disease. Diabetes mellitus and hypertension were reported in 40.1% and 26.1% of the patients, respectively. The best corrected visual acuity was 20/200 or worse in 43 (40.1%) eyes and 20/40 or better in 43 (40.1%) eyes. The best corrected visual acuity was significantly better in nondiabetic patients (0.62+/-0.69 LogMAR) than diabetics (0.96+/-0.84, P=0.03). The visual field analysis of reliable fields (76 eyes) revealed that the mean deviation ranged from -32.6 to -1.3 dB with a mean+/-SD of -19.7+/-8.08 dB. Diffuse defect was the most prevalent defect detected on 36.8% of visual fields of the study eyes followed by inferior altitudinal defect (26.3+/-). In the fellow eyes, without any evidence of prior optic nerve problem, inferior and superior arcuate scotoma were found in 30% and 20% of the eyes, respectively.


CONCLUSIONS
Characteristics of nonarteritic anterior ischemic optic neuropathy patients in a population of Iranian patients were similar to nonarteritic anterior ischemic optic neuropathy as described in previous studies, with the exception of higher proportion of younger patients and a higher propensity for diabetes. Visual field defects were common in clinically normal fellow eyes.
Falavarjani
Khalil Ghasemi
KG
Eye Research Center and Eye Department, Rassoul-e Akram Hospital, Iran University of Medical Sciences, Tehran 14455-364, Iran. drghasemi@yahoo.com
Sanjari
Mostafa Soltan
MS
Modarres
Mehdi
M
Aghamohammadi
Farzaneh
F
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D018917:Optic Neuropathy, Ischemic / Q000503:physiopathology*; D012017:Referral and Consultation; D012030:Refractive Errors; D013997:Time Factors; D014792:Visual Acuity; D014794:Visual Fields