Efficient and regioselective one-pot synthesis of 3-substituted and 3,5-disubstituted isoxazoles.
A series of 3-substituted and 3,5-disubstituted isoxazoles have been efficiently synthesized in moderate to excellent yields by the reaction of N-hydroxyl-4-toluenesulfonamide with alpha,beta-unsaturated aldehydes/ketones. This novel strategy is associated with readily available starting materials, mild conditions, high regioselectivity, and wide scope.
Tang
Shibing
S
State Key Laboratory of Applied Organic Chemistry, Department of Chemistry, Lanzhou University, Lanzhou 730000, PR China.
He
Jinmei
J
Sun
Yongquan
Y
He
Liuer
L
She
Xuegong
X
D002384:Catalysis; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism; D013449:Sulfonamides / Q000737:chemistry*; D014050:Toluene / Q000031:analogs & derivatives* / Q000737:chemistry
D007555:Isoxazoles; C543538:N-hydroxyl-4-toluenesulfonamide; D013449:Sulfonamides; D014050:Toluene