Resistance training improves cardiovascular risk factors in obese women despite a significative decrease in serum adiponectin levels.
Increased circulating adiponectin and insulin sensitivity are usually observed after body fat loss induced by a weight-loss diet. Progressive resistance training (PRT) without a concomitant weight-loss diet significantly decreases visceral fat, thus improving insulin sensitivity. Therefore, the purpose of this study was to ascertain the effects of combined 16-week PRT and weight-loss diet on circulating adiponectin and insulin sensitivity index. Thirty-four obese (BMI: 30-40 kg/m(2)) women, aged 40-60 year, were randomized to three groups: a control group (C; n = 9); a diet group (WL; n = 12) with a caloric restriction of 500 kcal/d; and a diet plus resistance training group (WL+RT; n = 13) with the same caloric restriction as group WL and a 16-week supervised whole body PRT of two sessions/week. Both WL and WL+RT groups showed similar decreases in body mass (-6.3% and -7.7%) and visceral fat (-19.9% and -20.5%). WL resulted in an expected increase in circulating levels of adiponectin (P = 0.07) and insulin sensitivity. However, circulating total adiponectin decreased (P < 0.05) in WL+RT group, whereas an improvement in different cardiovascular risk factors (insulin sensitivity, low-density lipoprotein cholesterol (LDL-C), etc.) was observed. In conclusion, in obese women a 16-week combined PRT and weight-loss diet is accompanied by significant improvements in different cardiovascular risk factors in spite of a significant decrease of circulating adiponectin.
Ibáñez
Javier
J
Research and Sports Medicine Center, Government of Navarra, Pamplona, Spain. jibanezs@navarra.es
Izquierdo
Mikel
M
Martínez-Labari
Cristina
C
Ortega
Francisco
F
Grijalba
Ana
A
Forga
Luis
L
Idoate
Fernando
F
García-Unciti
Marisol
M
Fernández-Real
José M
JM
Gorostiaga
Esteban M
EM
D052242:Adiponectin / Q000097:blood*; D000328:Adult; D031204:Caloric Restriction; D002318:Cardiovascular Diseases / Q000097:blood / Q000517:prevention & control*; D008078:Cholesterol, LDL / Q000097:blood; D003131:Combined Modality Therapy; D004038:Diet, Reducing; D015444:Exercise / Q000502:physiology; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D050152:Intra-Abdominal Fat / Q000378:metabolism*; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000628:therapy*; D055070:Resistance Training; D012307:Risk Factors; D015431:Weight Loss
D052242:Adiponectin; D008078:Cholesterol, LDL