title: Fully automated synthesis and initial PET evaluation of [11C]PBR28.
abstract: Fully automated synthesis and initial PET evaluation of a TSPO radioligand, [11C]PBR28 (N-(2-[11C]methoxybenzyl)-N-(4-phenoxypyridin-3-yl)acetamide), are reported. These results facilitate the potential preclinical and clinical PET studies of [11C]PBR28 in animals and humans.
authors.affiliation: Department of Radiology, Indiana University School of Medicine, 950 West Walnut Street, Room 427, Indianapolis, IN 46202, USA.
authors.forename: Min
authors.initials: M
authors.lastname: Wang
authors.forename: Karmen K
authors.initials: KK
authors.lastname: Yoder
authors.forename: Mingzhang
authors.initials: M
authors.lastname: Gao
authors.forename: Bruce H
authors.initials: BH
authors.lastname: Mock
authors.forename: Xiao-Ming
authors.initials: XM
authors.lastname: Xu
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Saykin
authors.forename: Gary D
authors.initials: GD
authors.lastname: Hutchins
authors.forename: Qi-Huang
authors.initials: QH
authors.lastname: Zheng
mesh_terms: D000818:Animals; D002250:Carbon Radioisotopes; D002352:Carrier Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D005260:Female; D058787:GABA-A Receptor Antagonists; D008024:Ligands; D049268:Positron-Emission Tomography; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D011963:Receptors, GABA-A / Q000378:metabolism
chemical_list: C526315:(methyl-(11)C)N-acetyl-N-(2-methoxybenzyl)-2-phenoxy-5-pyridinamine; D002250:Carbon Radioisotopes; D002352:Carrier Proteins; D058787:GABA-A Receptor Antagonists; D008024:Ligands; D011743:Pyrimidines; D019275:Radiopharmaceuticals; D011963:Receptors, GABA-A; C069997:Tspo protein, rat