Successful treatment of severe or methotrexate-resistant juvenile localized scleroderma with mycophenolate mofetil.
OBJECTIVE
To evaluate the efficacy of mycophenolate mofetil (MMF) in the treatment of severe refractory juvenile localized scleroderma (JLS).


METHODS
A retrospective chart review was performed in patients with JLS who had been treated with MMF after the failure of a combination of MTX and corticosteroids for at least 4 months, or whose JLS had concomitant severe extracutaneous manifestations. Outcome was assessed through clinical examination and thermography. Adverse events were recorded.


RESULTS
Ten patients (six females and four males) were enrolled in the study. JLS clinical subtypes were deep morphoea (two patients with disabling pansclerotic morphoea), generalized morphoea (three patients), linear scleroderma (five patients) affecting the limbs in two and face in three patients (en coup de sabre). The age at onset of disease was 8 (range 2-16) years, and the disease duration at the time of treatment with MMF was 18 (range 8-62) months. All MMF-treated patients experienced clinical improvement that allowed withdrawal or reduction of doses of corticosteroids and MTX. Over a follow-up of 27 (range 6-36) months, mild abdominal discomfort was reported in only one patient.


CONCLUSIONS
MMF appears to be effective in arresting disease progression in severe or MTX-refractory JLS and is generally well tolerated. Further controlled studies are needed to confirm these data.
Martini
Giorgia
G
Pediatric Rheumatology Unit, University of Padova, Via Giustiniani 2, Padova 35128, Italy. martini@pediatria.unipd.it
Ramanan
Athimalaipet V
AV
Falcini
Fernanda
F
Girschick
Hermann
H
Goldsmith
Donald P
DP
Zulian
Francesco
F
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004341:Drug Evaluation; D004351:Drug Resistance; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use*; D009173:Mycophenolic Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use; D012189:Retrospective Studies; D012594:Scleroderma, Localized / Q000188:drug therapy* / Q000473:pathology; D016896:Treatment Outcome
D007166:Immunosuppressive Agents; D009173:Mycophenolic Acid; D008727:Methotrexate