title: Seizure severity is associated with quality of life independent of seizure frequency.
abstract: OBJECTIVE
  The goal of the work described here was to determine whether seizure severity is associated with quality of life and if this association exists independent of seizure frequency.
  
  
  METHODS
  We administered a survey questionnaire to patients followed at the Comprehensive Epilepsy Program, University of Florida Health Sciences Center/Jacksonville.
  
  
  RESULTS
  The study population comprised 142 subjects. On univariate analysis, increased seizure severity (as measured with the revised Liverpool Seizure Severity Scale, LSSS) and seizure frequency were significantly associated with poorer Quality of Life in Epilepsy-10 (QOLIE-10) scores. Most items on the LSSS were significantly associated with QOLIE-10 scores, as well as the various scales of the QOLIE-10. Likewise, all QOLIE-10 scales were significantly associated with overall LSSS scores. The correlation between seizure severity and frequency was insignificant. On multiple linear regression, both seizure severity and frequency were independently associated with QOLIE-10 scores.
  
  
  CONCLUSIONS
  Seizure severity is associated with quality of life and this association exists independent of seizure frequency.
authors.affiliation: Comprehensive Epilepsy Program, Department of Neurology, University of Florida Health Sciences Center/Jacksonville, Jacksonville, FL 32209, USA. ramon.bautista@jax.ufl.edu
authors.forename: Ramon Edmundo D
authors.initials: RE
authors.lastname: Bautista
authors.forename: E Tannahill
authors.initials: ET
authors.lastname: Glen
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D005260:Female; D006306:Health Surveys; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D011594:Psychometrics; D011788:Quality of Life / Q000523:psychology*; D012640:Seizures / Q000503:physiopathology* / Q000523:psychology*; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires; D055815:Young Adult