title: Successful pregnancy in an ovarian agenesis patient after modified natural cycle IVF oocyte donation.
abstract: The recovery of a mature oocyte from a modified natural cycle followed by in-vitro fertilization (nIVF) is an attractive alternative to conventional IVF, involving ovarian stimulation, in the treatment of female infertility. Ovarian agenesis is a rare disorder resulting in primary amenorrhoea and infertility in affected females. A couple sought help for infertility due to ovarian agenesis of the female partner and decided to pursue treatment utilizing oocyte donation. Modified natural-cycle egg retrieval was carried out on the donor; one mature oocyte was retrieved and underwent IVF using a sperm sample from the male partner. A good-quality embryo was transferred, A viable pregnancy was confirmed by ultrasound scan and resulted in the delivery of a healthy baby boy at 36 weeks' gestation. This is the second published report of an ongoing clinical pregnancy and subsequent birth resulting from oocyte donation recovered during a modified natural cycle. The use of less invasive assisted reproduction techniques such as nIVF can be used in oocyte donation cycles successfully.
authors.affiliation: University of Montreal, Department of Obstetrics and Gynecology, Saint Luc Hospital (CHUM), 1058 rue Saint-Denis, Montreal, Québec, Canada. ij.kadoch@umontreal.ca
authors.forename: Isaac Jacques
authors.initials: IJ
authors.lastname: Kadoch
authors.forename: Wael
authors.initials: W
authors.lastname: Jamal
authors.forename: Simon J
authors.initials: SJ
authors.lastname: Phillips
authors.forename: Robert
authors.initials: R
authors.lastname: Hemmings
authors.forename: Louise
authors.initials: L
authors.lastname: Lapensée
authors.forename: Bernard
authors.initials: B
authors.lastname: Couturier
authors.forename: François
authors.initials: F
authors.lastname: Bissonnette
mesh_terms: D000328:Adult; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D008297:Male; D009865:Oocytes; D010053:Ovary / Q000473:pathology*; D011247:Pregnancy; D011256:Pregnancy Outcome; D014019:Tissue Donors