title: The prevalence of germ-line TP53 mutations in women diagnosed with breast cancer before age 30.
abstract: Germ-line mutations in the TP53 gene are rare, but predispose women to a range of cancer types, including early-onset breast cancer. Breast cancers in women from families with the Li-Fraumeni syndrome often occur before age 30. The prevalence of deleterious TP53 mutations in unselected women with early-onset breast cancer is not precisely known. If mutations were found to be sufficiently common, it might be prudent to offer genetic testing to affected women in this age group. We screened the entire TP53 gene in the germ-line DNA from 95 women of various ethnic groups who were diagnosed with breast cancer before age 30, and who had previously been found to be negative for BRCA1 and BRCA2 mutations. No TP53 mutation was found. This study does not support a policy that TP53 testing should be offered routinely to unselected women with early-onset breast cancer in the absence of a family history of cancer.
authors.affiliation: Department of Medicine, Division of Medical Oncology, University of Toronto, Toronto, Canada.
authors.forename: Ophira M
authors.initials: OM
authors.lastname: Ginsburg
authors.forename: Mohammad R
authors.initials: MR
authors.lastname: Akbari
authors.forename: Zeba
authors.initials: Z
authors.lastname: Aziz
authors.forename: Robert
authors.initials: R
authors.lastname: Young
authors.forename: Henry
authors.initials: H
authors.lastname: Lynch
authors.forename: Parviz
authors.initials: P
authors.lastname: Ghadirian
authors.forename: Andre
authors.initials: A
authors.lastname: Robidoux
authors.forename: Julian
authors.initials: J
authors.lastname: Londono
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Vasquez
authors.forename: Magda
authors.initials: M
authors.lastname: Gomes
authors.forename: Mauricio Magalhaes
authors.initials: MM
authors.lastname: Costa
authors.forename: Constantine
authors.initials: C
authors.lastname: Dimitrakakis
authors.forename: Gustavo
authors.initials: G
authors.lastname: Gutierrez
authors.forename: Robert
authors.initials: R
authors.lastname: Pilarski
authors.forename: Robert
authors.initials: R
authors.lastname: Royer
authors.forename: Steven A
authors.initials: SA
authors.lastname: Narod
mesh_terms: D000328:Adult; D017668:Age of Onset; D001943:Breast Neoplasms / Q000235:genetics*; D004252:DNA Mutational Analysis; D005260:Female; D016158:Genes, p53 / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D018095:Germ-Line Mutation; D006801:Humans; D016864:Li-Fraumeni Syndrome / Q000150:complications / Q000235:genetics; D010375:Pedigree; D015995:Prevalence; D055815:Young Adult