Gastric B-cell lymphoma with Mott cell differentiation in a dog.
A gastric lymphoid tumor with involvement of regional lymph nodes and spleen was diagnosed in an 8-year-old crossbreed male dog with a 6-month history of gastrointestinal disease. Despite surgical excision and palliative therapy (prednisolone and cimetidine), the dog was euthanatized due to worsening of clinical signs. At necropsy, multiple white, solid, nodular, infiltrative masses were observed in the stomach, duodenum, spleen, liver, and lungs in association with generalized lymph node enlargement. Cytology, histology, histochemistry, immunohistochemistry, and electron microscopy revealed that the neoplastic cell population was composed of B lymphocytes that contained variable amounts of round periodic acid-Schiff-positive cytoplasmic globules consistent with Russell bodies. The tumor most likely represented a variant of B-cell neoplasia with extensive Mott cell differentiation.
De Zan
Gabrita
G
Dipartimento di Sanità Pubblica, Patologia Comparata ed Igiene Veterinaria, Facoltà di Medicina Veterinaria, Università degli Studi di Padova, Agripolis, Viale dell'Università, 16, 35020 Legnaro, Padova, Italy. gabrita.dezan@unipd.it
Zappulli
Valentina
V
Cavicchioli
Laura
L
Di Martino
Linda
L
Ros
Eriberta
E
Conforto
Giorgia
G
Castagnaro
Massimo
M
D000818:Animals; D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D002454:Cell Differentiation; D002927:Cimetidine / Q000627:therapeutic use; D004283:Dog Diseases / Q000473:pathology* / Q000601:surgery; D004285:Dogs; D005065:Euthanasia; D005767:Gastrointestinal Diseases / Q000473:pathology / Q000601:surgery; D016393:Lymphoma, B-Cell / Q000473:pathology / Q000601:surgery / Q000648:ultrastructure / Q000662:veterinary*; D008297:Male; D010166:Palliative Care; D011239:Prednisolone / Q000627:therapeutic use; D013274:Stomach Neoplasms / Q000473:pathology / Q000601:surgery / Q000648:ultrastructure / Q000662:veterinary*
D000897:Anti-Ulcer Agents; D002927:Cimetidine; D011239:Prednisolone