title: The long-term retention of pregabalin in a large cohort of patients with epilepsy at a tertiary referral centre.
abstract: Pregabalin (PGB) is a new antiepileptic drug (AED) which is a structural, non-functional analogue of gamma-aminobutyric acid. It acts at presynaptic calcium channels to modulate neurotransmitter release in the CNS. While the efficacy and tolerability of PGB have been demonstrated in several randomised controlled trials, few studies have addressed long-term outcome in large groups of patients. A cohort of patients attending a tertiary referral centre for epilepsy was identified as having started taking PGB. Patients' data were obtained through medical records. Of 402 patients included, 42% of patients were still taking PGB at last follow-up. The estimated 2.5-year retention rate was 32%. Males appeared more likely to continue on PGB therapy than females. The common adverse experiences (AEs) leading to withdrawal were CNS-related, psychiatric AEs and weight gain. Published retention rates for levetiracetam appear to be higher, and those for gabapentin lower, than the rates estimated for PGB.
authors.affiliation: Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, National Hospital for Neurology and Neurosurgery, London, UK.
authors.forename: Alan W C
authors.initials: AW
authors.lastname: Yuen
authors.forename: Rinki
authors.initials: R
authors.lastname: Singh
authors.forename: Gail S
authors.initials: GS
authors.lastname: Bell
authors.forename: Anupam
authors.initials: A
authors.lastname: Bhattacharjee
authors.forename: Aidan
authors.initials: A
authors.lastname: Neligan
authors.forename: Dominic C
authors.initials: DC
authors.lastname: Heaney
authors.forename: John S
authors.initials: JS
authors.lastname: Duncan
authors.forename: Josemir W
authors.initials: JW
authors.lastname: Sander
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000927:Anticonvulsants / Q000009:adverse effects; D016009:Chi-Square Distribution; D004827:Epilepsy / Q000188:drug therapy*; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008499:Medical Records; D008875:Middle Aged; D017060:Patient Satisfaction; D000069583:Pregabalin; D012044:Regression Analysis; D012737:Sex Factors; D016896:Treatment Outcome; D005680:gamma-Aminobutyric Acid / Q000009:adverse effects / Q000031:analogs & derivatives*
chemical_list: D000927:Anticonvulsants; D000069583:Pregabalin; D005680:gamma-Aminobutyric Acid