Colocalization of 5-HT1F receptor and calcitonin gene-related peptide in rat vestibular nuclei.
The aim of this study was to determine whether calcitonin gene-related peptide (CGRP) colocalizes with 5-HT(1F) receptor in rat vestibular nuclei using a double immunohistochemical staining procedure. The frequent co-occurrence of migraine and balance disorders suggests a pathophysiologic link between the two. However, the mechanism of migrainous vertigo has not been elucidated, though serotonin (5-HT) and its receptors are believed to involve in the pathogenesis of migrainous vertigo. Furthermore, 5-HT(1F) receptor agonists and CGRP receptor antagonists have recently attracted attention as potential treatments for migraine, and CGRP release from trigeminal neurons has been associated with migraine. This study demonstrates the colocalization of 5-HT(1F) receptor and CGRP in the rat vestibular nuclei, which suggests that 5-HT(1F) receptor regulates the release of CGRP from vestibular nuclei. This finding indicates that 5-HT(1F) receptor agonists may ameliorate migrainous vertigo by attenuating elevated levels of CGRP release from vestibular nuclei.
Ahn
Seong-Ki
SK
Department of Otolaryngology, College of Medicine, Gyeongsang National University, Jinju, South Korea. skahn@gnu.ac.kr
Khalmuratova
Roza
R
Jeon
Sea-Yuong
SY
Kim
Jin-Pyeong
JP
Park
Jung Je
JJ
Hur
Dong Gu
DG
Balaban
Carey D
CD
D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D009474:Neurons / Q000378:metabolism*; D010784:Photomicrography; D051381:Rats; D017207:Rats, Sprague-Dawley; D011985:Receptors, Serotonin / Q000378:metabolism*; D014726:Vestibular Nuclei / Q000378:metabolism*; D000096642:Receptor, Serotonin, 5-HT1F
D015740:Calcitonin Gene-Related Peptide; D011985:Receptors, Serotonin; D000096642:Receptor, Serotonin, 5-HT1F