[Fifteen cases of food-borne botulism in Morocco: significant diagnostic contribution of electrodiagnosis].
BACKGROUND
Botulism is a rare but serious disease, which affects the peripheral autonomous nervous system, potentially with a fatal outcome. In Morocco, botulism is exceptional.


METHODS
This was a prospective analysis of the epidemiological, clinical, neurophysiological and toxicological features of 15 cases of food-borne botulism identified among a series of 45 highly suspect cases collected in Morocco during an epidemic in August1999.


RESULTS
The 15 patients (eight females, seven males) included in the protocol were aged 3 to 49 years (average 18.8 years). One-third of the cases occurred in a familial context. The clinical presentation was typical and complete in nine cases; respiratory failure was noted in four patients. Botulinum toxins were found in nine cases. Outcome was less than favorable, with total recovery in seven cases, persistence of motor sequelae in three and death in five. Electrophysiological investigations showed an incrementing response at high frequency in 73.3%, a decrement at lower frequency in 60% and low motor amplitudes in 93%. These findings constituted a very sensitive and specific triad for botulism diagnosis.


CONCLUSIONS
These findings illustrate the gravity of botulism and the important diagnostic value of neurophysiological results, especially incrementation, which can provide a very pertinent diagnostic contribution, especially in seronegative patients.
Kissani
N
N
Département de neurologie, hôpital Ibn Tofail, CHU Mohamed VI, faculté de médecine, BP 7010, 4000 Marrakech Sidi Abbad, Maroc. najibkis@gmail.com
Moutawakkil
S
S
Chakib
A
A
Slassi
I
I
D000293:Adolescent; D000328:Adult; D001905:Botulinum Toxins / Q000097:blood; D001906:Botulism / Q000175:diagnosis* / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D004568:Electrodiagnosis / Q000379:methods; D004594:Electrophysiology / Q000379:methods; D005260:Female; D005502:Food / Q000145:classification; D005517:Foodborne Diseases / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009018:Morocco; D011446:Prospective Studies; D055815:Young Adult
D001905:Botulinum Toxins