title: Human papillomavirus in women with and without HIV-1 infection attending an STI clinic in Vitoria, Brazil.
abstract: We conducted a cross-sectional study in Vitória, Brazil, to assess the prevalence of human papillomavirus (HPV) infection in HIV-positive and HIV-negative women attending a sexually transmitted infection (STI)/AIDS clinic. We also investigated the presence of HPV genotypes and assessed covariates for HIV infection. Enrolled patients received a gynecological evaluation, and cervical scrape samples were collected for cytological analysis and HPV-DNA polymerase chain reaction (PCR). A blood sample was obtained to determine HIV status. HPV infection and squamous intraepithelial lesions were studied in 284 women, 112 (39.4%) HIV-positive women and 172 (60.5%) HIV-negative women. HPV-DNA was detected in 133 (46.8%). HIV-infected women were almost twice as likely to be concurrently infected with HPV than HIV-negative women (OR = 1.87 95% CI: 1.16-3.03). The high proportion of HPV detected among women attending an STI/AIDS clinic, particularly among HIV-infected women, proves the importance of screening this high-risk group in the hope of earlier detection and treatment of cervical intraepithelial neoplasia (CIN).
authors.affiliation: Nucleo de Doencas Infecciosas, Universidade Federal do Espirito Santo, Brazil.
authors.forename: Bettina Moulin
authors.initials: BM
authors.lastname: Coelho Lima
authors.forename: Jonathan E
authors.initials: JE
authors.lastname: Golub
authors.forename: Adriana
authors.initials: A
authors.lastname: Tonani Mattos
authors.forename: Luciana Bueno de
authors.initials: LB
authors.lastname: Freitas
authors.forename: Liliana
authors.initials: L
authors.lastname: Cruz Spano
authors.forename: Angélica
authors.initials: A
authors.lastname: Espinosa Miranda
mesh_terms: D000328:Adult; D000554:Ambulatory Care Facilities; D001938:Brazil / Q000453:epidemiology; D003430:Cross-Sectional Studies; D004279:DNA, Viral / Q000032:analysis; D004522:Educational Status; D005260:Female; D005838:Genotype; D015658:HIV Infections / Q000453:epidemiology*; D015497:HIV-1; D006801:Humans; D016015:Logistic Models; D030361:Papillomavirus Infections / Q000453:epidemiology*; D015995:Prevalence; D012747:Sexual Partners; D002583:Uterine Cervical Neoplasms / Q000473:pathology; D014626:Vaginal Smears; D002578:Uterine Cervical Dysplasia / Q000473:pathology
chemical_list: D004279:DNA, Viral