title: Synthesis, characterization and antimicrobial evaluation of novel imines and thiazolidinones.
abstract: 2-(4-Chloro-3-methylphenoxy)acetohydrazide (2) derived from ethyl 2-(4-chloro-3-methylphenoxy) acetate (1) was reacted with different aromatic aldehydes to yield N-(substituted benzylidiene)-2-(4-chloro-3-methylphenoxy)acetamide (3a-e). Cyclization of compound (3a-e) with thioglycolic acid yielded 2-(4-chloro-3-methylphenoxy)-N-(4-oxo-2-arylthiazolidin-3-yl) acetamide (4a-e). The newly synthesized compounds were characterized on the basis of spectral studies and evaluated for antibacterial and antifungal activities.
authors.affiliation: Department of Pharmacy, Rameesh Institute of Vocational and Technical Education, 3-Knowledge park-1, Kasna road, Greater Noida, India. nfuloria@rediffmail.com
authors.forename: Neeraj Kumar
authors.initials: NK
authors.lastname: Fuloria
authors.forename: Vijender
authors.initials: V
authors.lastname: Singh
authors.forename: Mohammad Shahar
authors.initials: MS
authors.lastname: Yar
authors.forename: Mohammed
authors.initials: M
authors.lastname: Ali
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D007097:Imines / Q000138:chemical synthesis* / Q000494:pharmacology*; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D013055:Spectrophotometry, Infrared; D053778:Thiazolidines / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D007097:Imines; D007202:Indicators and Reagents; D053778:Thiazolidines