Torque Teno Virus (TTV) distribution in healthy Russian population.
BACKGROUND
Torque teno virus (TTV) is a circular, single-stranded DNA virus that chronically infects healthy individuals of all ages worldwide. There is a lot of data on the prevalence and genetic heterogeneity of TTV in healthy populations and in patients with various diseases now available. However, little is known about TTV load among healthy human population. In this study we analyzed TTV load in the group of 512 Russian elite athletes, who are supposed to be, by some standards, the healthiest part of the human population.


RESULTS
The prevalence rate of TTV among the Russian Olympic Reserve members was 94% (for test sensitivity about 1000 genome equivalents per 1 ml of blood). Quantities varied from 103 (which corresponded to detection limit) to 1010 copies per 1 ml of blood, with median at 2.7 x 106 copies.


CONCLUSIONS
About 94% of healthy individuals in Russian population have more than 1000 TTV genome copies per 1 ml of blood. This result exceeds the previously published data, and can be explained by either more sensitive PCR test system or by higher TTV distribution in Russian population or both. TTV viral load neither depends on gender, nor age.
Vasilyev
Evgeny V
EV
DNA-Technology JSC, Kashirskoe shosse, 23-5-16, Moscow, 115478, Russia. e.vasilyev@dna-technology.ru
Trofimov
Dmitry Y
DY
Tonevitsky
Alexander G
AG
Ilinsky
Valery V
VV
Korostin
Dmitriy O
DO
Rebrikov
Denis V
DV
D000293:Adolescent; D000328:Adult; D002353:Carrier State / Q000208:ethnology / Q000821:virology*; D002648:Child; D005260:Female; D018628:Gene Dosage; D005838:Genotype; D006304:Health Status; D006801:Humans; D008297:Male; D012426:Russia / Q000453:epidemiology; D013177:Sports; D022783:Torque teno virus / Q000235:genetics / Q000302:isolation & purification*; D019562:Viral Load; D055815:Young Adult