A novel HLA-B allele, B*5214, detected in a Taiwanese volunteer bone marrow donor using a sequence-based typing method.
HLA-B*5214, a novel rare allele of HLA-B*52 variant, was found in a Taiwanese volunteer bone marrow donor by sequence-based typing method. The sequence of B*5214 is identical to that of B*520101 in exon 2 but differs from B*520101 in exon 3 at nucleotide positions 419 A-->T and 435 A-->G. Alteration of these two nucleotides resulted an amino acid substitution at amino acid residue 116 Y-->F ( TAC-->TTC) and a silent exchange at residue 121 K-->K (AAA-->AAG).
Chen
M J
MJ
Buddhist Tzu Chi Stem Cells Centre, Buddhist Tzu Chi Medical Centre, Buddhist Compassion Relief Tzu Chi Foundation, Hualien, Taiwan.
Chu
C C
CC
Shyr
M H
MH
Lin
C L
CL
Lin
P Y
PY
Yang
K L
KL
D000483:Alleles; D000595:Amino Acid Sequence; D001483:Base Sequence; D001853:Bone Marrow / Q000502:physiology*; D005091:Exons / Q000235:genetics; D015235:HLA-B Antigens / Q000737:chemistry / Q000235:genetics*; D006650:Histocompatibility Testing / Q000379:methods*; D006801:Humans; D008969:Molecular Sequence Data; D017421:Sequence Analysis / Q000379:methods*; D013624:Taiwan; D014019:Tissue Donors
D015235:HLA-B Antigens