title: Sister Mary Joseph's nodule: a case of umbilical cutaneous metastasis with signet ring cell histology.
abstract: The metastasis of a visceral malignancy to the umbilicus is known as "Sister Mary Joseph's nodule". It is a rare clinical sign indicating advanced, metastasizing intraabdominal cancer. We report a 50-year-old man who developed metastatic skin cancer in the form of semicircular indurated plaque on top of which was a firm mobile rounded nodule at the umbilical area. Histopathological examination demonstrated diastase-resistant periodic acid-Schiff and mucicarmine positive signet ring cells, suggesting gastric carcinoma. Immunohistochemical staining showed that these cells were positive for cytokeratins and epithelial membrane antigen, suggesting epithelial origin.
authors.affiliation: Department of Dermatology, Adan Hospital, Kuwait. walid_md2000@hotmail.com
authors.forename: Valid Bagher
authors.initials: VB
authors.lastname: Zadeh
authors.forename: Randhir
authors.initials: R
authors.lastname: Kadyan
authors.forename: Adel
authors.initials: A
authors.lastname: Al-Abdulrazzaq
authors.forename: Sultan
authors.initials: S
authors.lastname: Al-Otaibi
authors.forename: Amr
authors.initials: A
authors.lastname: Sarhan
authors.forename: Nabeel
authors.initials: N
authors.lastname: Najem
mesh_terms: D006801:Humans; D008297:Male; D008875:Middle Aged; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000556:secondary*; D014472:Umbilicus / Q000473:pathology*