title: A review of the applications of tissue microarray technology in understanding the molecular features of endometrial carcinoma.
abstract: OBJECTIVE
  To review the literature regarding the use of tissue microarray (TMA) technology in understanding the biology, diagnosis and prognosis of endometrial carcinoma (EC).
  
  
  METHODS
  This review of TMA technology in EC was based on a large number of published articles. We focused on the use of TMA technology as a tool to gain insight in endometrial carcinogenesis and to validate data obtained from DNA microarrays, proteomics and cellular models.
  
  
  RESULTS
  We summarized the technical aspects of the 37 articles that were reviewed. The number of EC cases in each series varied from 32-485 (median, 128). The number of cores ranged from 1-4 (median, 2), and the size of the cores ranged from 0.6-2 mm (median, 0.6 mm). Only 3 studies applied fluorescence in situ hybridization technology, while the remaining 34 studies used immunohistochemistry.
  
  
  CONCLUSIONS
  TMA can help to establish new prognostic markers and to define protein biomarkers that help in differential diagnosis.
authors.affiliation: Department of Pathology and Molecular Genetics, Hospital Universitari Arnau de Vilanova, University of Lleida, IRBLLEIDA, Lleida, Spain.
authors.forename: Judit
authors.initials: J
authors.lastname: Pallares
authors.forename: Maria
authors.initials: M
authors.lastname: Santacana
authors.forename: Soraya
authors.initials: S
authors.lastname: Puente
authors.forename: Susana
authors.initials: S
authors.lastname: Lopez
authors.forename: Andree
authors.initials: A
authors.lastname: Yeramian
authors.forename: Nuria
authors.initials: N
authors.lastname: Eritja
authors.forename: Anabel
authors.initials: A
authors.lastname: Sorolla
authors.forename: David
authors.initials: D
authors.lastname: Llobet
authors.forename: Xavier
authors.initials: X
authors.lastname: Dolcet
authors.forename: Xavier
authors.initials: X
authors.lastname: Matias-Guiu
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D016889:Endometrial Neoplasms / Q000175:diagnosis* / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D020411:Oligonucleotide Array Sequence Analysis; D040901:Proteomics; D046888:Tissue Array Analysis / Q000295:instrumentation / Q000379:methods*
chemical_list: D015415:Biomarkers