title: Predictive value of osteocalcin in bone metastatic differentiated thyroid carcinoma.
abstract: OBJECTIVE
  To evaluate the diagnostic value of serum osteocalcin in the detection of bone metastases from differentiated thyroid carcinoma (DTC).
  
  
  METHODS
  Serum samples from DTC patients with (DTC BM+, n=19) or without bone metastases (DTC BM-, n=19), and matched healthy volunteers (n=30) were tested for serum osteocalcin with electrochemiluminescent immunoassay.
  
  
  RESULTS
  Osteocalcin was higher in DTC BM+ than in DTC BM- patients (+35.8%, p=0.002), acting as an independent risk factor for bone metastases (R(2)=0.142, p=0.039). The sensitivity was 78.9% and the specificity was 63.2% at a cut-off value of 11.2 microg/L.
  
  
  CONCLUSIONS
  Serial measurements of osteocalcin could be useful in the detection of bone metastases from DTC.
authors.affiliation: Department of Nuclear Medicine, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, 600 Yishan Road, Shanghai 200233, China. gaookok@163.com
authors.forename: Yunchao
authors.initials: Y
authors.lastname: Gao
authors.forename: Hankui
authors.initials: H
authors.lastname: Lu
authors.forename: Qiong
authors.initials: Q
authors.lastname: Luo
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Wu
authors.forename: Shiwei
authors.initials: S
authors.lastname: Sheng
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood; D014408:Biomarkers, Tumor / Q000097:blood*; D001859:Bone Neoplasms / Q000097:blood / Q000556:secondary; D024042:Collagen Type I / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D015675:Osteocalcin / Q000097:blood*; D011347:Procollagen / Q000097:blood; D013964:Thyroid Neoplasms / Q000097:blood / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D024042:Collagen Type I; D011347:Procollagen; D015675:Osteocalcin; D000469:Alkaline Phosphatase