Oncogenic EGFR signaling networks in glioma.
The epidermal growth factor receptor (EGFR) is a primary contributor to glioblastoma (GBM) initiation and progression. Here, we examine how EGFR and key downstream signaling networks contribute to the hallmark characteristics of GBM such as rapid cancer cell proliferation and diffused invasion. Additionally, we discuss current therapeutic options for GBM patients and elaborate on the mechanisms through which EGFR promotes chemoresistance. We conclude by offering a perspective on how the potential of integrative systems biology may be harnessed to develop safe and effective treatment strategies for this disease.
Huang
Paul H
PH
Protein Networks Team, Section of Cell and Molecular Biology, Institute of Cancer Research, London, UK. paul.huang@icr.ac.uk
Xu
Alexander M
AM
White
Forest M
FM
D000818:Animals; D049109:Cell Proliferation; D019008:Drug Resistance, Neoplasm; D005910:Glioma / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D006801:Humans; D009361:Neoplasm Invasiveness; D017468:Receptors, Fibroblast Growth Factor / Q000378:metabolism*; D015398:Signal Transduction
D017468:Receptors, Fibroblast Growth Factor