Idiopathic focal segmental glomerulosclerosis.
This study was conducted to determine the prognostic value of some clinical, laboratory, histopathologic and therapeutic factors in 62 children with focal segmental glomerulosclerosis. There were no significant differences between the factors studied, except for severe interstitial fibrosis, which was more frequent in patients with chronic kidney disease (P=0.03). The prevalence of chronic kidney disease in nonresponder groups was significantly higher (P <0.05). We found therapy with cyclophosphamide to be promising in patients with focal segmental glomerulosclerosis.
Naseri
Mitra
M
Department of Pediatrics, Mashhad University of Medical Sciences, Mashhad, Iran. Naserim@mums.ac.ir
Madani
Abbas
A
Attaii
Nematolah
N
Naseri
Homa
H
D000293:Adolescent; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D005923:Glomerulosclerosis, Focal Segmental / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology; D006801:Humans; D007223:Infant; D007492:Iran; D053208:Kaplan-Meier Estimate; D008297:Male; D009404:Nephrotic Syndrome; D015995:Prevalence; D018709:Statistics, Nonparametric; D013256:Steroids / Q000627:therapeutic use; D016896:Treatment Outcome
D013256:Steroids; D003520:Cyclophosphamide