title: Brain metabolic correlates of dopaminergic degeneration in de novo idiopathic Parkinson's disease.
abstract: OBJECTIVE
  The aim of the present study was to evaluate the reciprocal relationships between motor impairment, dopaminergic dysfunction, and cerebral metabolism (rCMRglc) in de novo Parkinson's disease (PD) patients.
  
  
  METHODS
  Twenty-six de novo untreated PD patients were scanned with (123)I-FP-CIT SPECT and (18)F-FDG PET. The dopaminergic impairment was measured with putaminal (123)I-FP-CIT binding potential (BP), estimated with two different techniques: an iterative reconstruction algorithm (BP(OSEM)) and the least-squares (LS) method (BP(LS)). Statistical parametric mapping (SPM) multiple regression analyses were performed to determine the specific brain regions in which UPDRS III scores and putaminal BP values correlated with rCMRglc.
  
  
  RESULTS
  The SPM results showed a negative correlation between UPDRS III and rCMRglc in premotor cortex, and a positive correlation between BP(OSEM) and rCMRglc in premotor and dorsolateral prefrontal cortex, not surviving at multiple comparison correction. Instead, there was a positive significant correlation between putaminal BP(LS) and rCMRglc in premotor, dorsolateral prefrontal, anterior prefrontal, and orbitofrontal cortex (p < 0.05, corrected for multiple comparison).
  
  
  CONCLUSIONS
  Putaminal BP(LS) is an efficient parameter for exploring the correlations between PD severity and rCMRglc cortical changes. The correlation between dopaminergic degeneration and rCMRglc in several prefrontal regions likely represents the cortical functional correlate of the dysfunction in the motor basal ganglia-cortical circuit in PD. This finding suggests focusing on the metabolic course of these areas to follow PD progression and to analyze treatment effects.
authors.affiliation: Department of Clinical Pathophysiology, University of Florence, Viale Morgagni 85, 50134, Florence, Italy. valentina.berti@unifi.it
authors.forename: Valentina
authors.initials: V
authors.lastname: Berti
authors.forename: Cristina
authors.initials: C
authors.lastname: Polito
authors.forename: Silvia
authors.initials: S
authors.lastname: Ramat
authors.forename: Eleonora
authors.initials: E
authors.lastname: Vanzi
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: De Cristofaro
authors.forename: Giannantonio
authors.initials: G
authors.lastname: Pellicanò
authors.forename: Francesco
authors.initials: F
authors.lastname: Mungai
authors.forename: Paolo
authors.initials: P
authors.lastname: Marini
authors.forename: Andreas Robert
authors.initials: AR
authors.lastname: Formiconi
authors.forename: Sandro
authors.initials: S
authors.lastname: Sorbi
authors.forename: Alberto
authors.initials: A
authors.lastname: Pupi
mesh_terms: D000465:Algorithms; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000378:metabolism; D006801:Humans; D007091:Image Processing, Computer-Assisted; D016018:Least-Squares Analysis; D008297:Male; D008875:Middle Aged; D009043:Motor Activity; D017072:Neostriatum / Q000378:metabolism; D010300:Parkinson Disease / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000503:physiopathology; D049268:Positron-Emission Tomography; D015899:Tomography, Emission-Computed, Single-Photon; D014326:Tropanes / Q000378:metabolism
chemical_list: D014326:Tropanes; D019788:Fluorodeoxyglucose F18; C087552:2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane; D004298:Dopamine