Lupane triterpene glycosides from leave of Acanthopanax koreanum and their cytotoxic activity.
One new lupane-triterpene glycoside, acankoreoside I (1), and four known compounds, acankoreoside A (2), acankoreoside D (3), acankoreoside F (4), and acantrifoside A (5), were isolated from the leaves of Acanthopanax koreanum (Araliaceae). Their chemical structures were elucidated by mass, 1D- and 2D-NMR spectroscopy. The structure of new compound 1 was determined to be 3alpha,11alpha,30-trihydroxylup-23-al-20(29)-en-28-oic acid 28-O-[alpha-L-rhamnopyranosyl-(1-->4)-beta-D-glucopyranosyl-(1-->6)-beta-D-glucopyranosyl] ester. The cytotoxic activities of these compounds were evaluated with four cancer cell lines such as A-549 (lung), HL-60 (acute promyelocytic leukemia), MCF-7 (breast), and U-937 (leukemia). Compound 1 showed growth inhibitory effect in A-549, HL-60, and MCF-7 cell lines with the IC(50) values of 8.2 microM, 12.1 microM, and 28.6 microM, respectively, whereas it was less active in the U937 cell line (the IC(50) >100 microM).
Nhiem
Nguyen Xuan
NX
Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, Vietnam.
Tung
Nguyen Huu
NH
Kiem
Phan Van
PV
Minh
Chau Van
CV
Ding
Yan
Y
Hyun
Jae-Hee
JH
Kang
Hee-Kyoung
HK
Kim
Young Ho
YH
D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D028001:Eleutherococcus / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology / Q000633:toxicity; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D018515:Plant Leaves / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D053978:Pentacyclic Triterpenes
D000970:Antineoplastic Agents; D006027:Glycosides; D014315:Triterpenes; C545002:acankoreoside I; C480546:lupane; D053978:Pentacyclic Triterpenes