BATF: bringing (in) another Th17-regulating factor.
T helper (Th) 17 cells are a recently identified subset of T cells that regulate tissue inflammation, and RORgammat and RORalpha have been shown to be Th17-specific transcription factors that mediate Th17 cell generation. A new study of Batf-deficient mice shows that this AP-1 family transcription factor also regulates Th17 cell differentiation by binding to Th17-associated gene promoters and by maintaining RORalpha and RORgammat expression, shedding new lights on current clinical modulation of Th17 cell function in inflammatory diseases.
Martinez
Gustavo J
GJ
Department of Immunology and Center for Cancer Immunology Research, University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
Dong
Chen
C
D000818:Animals; D050976:Basic-Leucine Zipper Transcription Factors / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D002454:Cell Differentiation; D016207:Cytokines / Q000378:metabolism; D008213:Lymphocyte Activation / Q000276:immunology; D051379:Mice; D057093:Orphan Nuclear Receptors / Q000378:metabolism; D006377:T-Lymphocytes, Helper-Inducer / Q000166:cytology / Q000378:metabolism*
D050976:Basic-Leucine Zipper Transcription Factors; C431772:Batf protein, mouse; D016207:Cytokines; D057093:Orphan Nuclear Receptors