A direct synthesis of 5,6-dihydroindolo[2,1-a]isoquinolines that exhibit immunosuppressive activity.
Dihydroindolo[2,1-a]isoquinolines were synthesized from tetrahydroisoquinolines and alpha-fluoroaldehydes by a novel two-step procedure. These compounds exhibited significant immunosuppressive activity against IL-2, IL-10 and IFN-gamma.
Kraus
George A
GA
Department of Chemistry, Iowa State University, Ames, IA 50011, USA. gakraus@iastate.edu
Gupta
Vinayak
V
Kohut
Marian
M
Singh
Navrozedeep
N
D000447:Aldehydes / Q000737:chemistry; D000818:Animals; D007166:Immunosuppressive Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D007371:Interferon-gamma / Q000378:metabolism; D016753:Interleukin-10 / Q000378:metabolism; D007376:Interleukin-2 / Q000378:metabolism; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism; D044005:Tetrahydroisoquinolines / Q000737:chemistry
D000447:Aldehydes; D007166:Immunosuppressive Agents; D007376:Interleukin-2; D007546:Isoquinolines; D044005:Tetrahydroisoquinolines; D016753:Interleukin-10; D007371:Interferon-gamma