Intramyocardial angiogenic cell precursors in nonischemic dilated cardiomyopathy.
To determine the efficacy of intramyocardial injection of angiogenic cell precursors in nonischemic dilated cardiomyopathy, 35 patients with nonischemic dilated cardiomyopathy underwent injections of angiogenic cell precursors into the left ventricle (cell group). Seventeen patients with nonischemic dilated cardiomyopathy were matched from the heart failure database to form a control group that was treated medically. Angiogenic cell precursors were obtained from autologous blood, cultured in vitro, and injected into all free-wall areas of the left ventricle in the cell group. After these injections, New York Heart Association functional class improved significantly by 1.1 +/- 0.7 classes at 284.7 +/- 136.2 days, and left ventricular ejection fraction improved in 71.4% of patients (25/35); the mean increase in left ventricular ejection fraction was 4.4% +/- 10.6% at 192.7 +/- 135.1 days. Improved quality of life was demonstrated by better physical function, role-physical, general health, and vitality domains in a short-form health survey at the 3-month follow-up. In the control group, there were no significant improvements in left ventricular ejection fraction or New York Heart Association class which increased by 0.6 +/- 0.8 classes. It was concluded that intramyocardial angiogenic cell precursor injection is probably effective in the treatment of nonischemic dilated cardiomyopathy.
Arom
Kitipan V
KV
Cardiovascular Surgery, Bangkok Heart Hospital, Bangkok, Thailand. karom@bangkokheart.com
Ruengsakulrach
Permyos
P
Belkin
Michael
M
Tiensuwan
Montip
M
D000328:Adult; D053687:Adult Stem Cells / Q000637:transplantation*; D000368:Aged; D002311:Cardiomyopathy, Dilated / Q000401:mortality / Q000503:physiopathology / Q000601:surgery*; D016022:Case-Control Studies; D002478:Cells, Cultured; D005240:Feasibility Studies; D006801:Humans; D008875:Middle Aged; D018919:Neovascularization, Physiologic; D036102:Peripheral Blood Stem Cell Transplantation; D011788:Quality of Life; D020127:Recovery of Function; D012720:Severity of Illness Index; D013318:Stroke Volume; D013997:Time Factors; D016896:Treatment Outcome; D016277:Ventricular Function, Left