Aromatic heterocycles as activating groups for asymmetric conjugate addition reactions. Enantioselective copper-catalyzed reduction of 2-alkenylheteroarenes.
The versatility of chiral copper hydride catalysis has been demonstrated through development of highly enantioselective 1,4-reductions of 2-alkenylheteroarenes, substrates that have been rarely considered for asymmetric conjugate addition reactions. Both azoles and azines serve as efficient activating groups for this process.
Rupnicki
Leszek
L
School of Chemistry, University of Edinburgh, Joseph Black Building, The King's Buildings, West Mains Road, Edinburgh EH9 3JJ, United Kingdom.
Saxena
Aakarsh
A
Lam
Hon Wai
HW