title: Direct synthesis of medium-bridged twisted amides via a transannular cyclization strategy.
abstract: The sequential RCM to construct a challenging medium-sized ring followed by a transannular cyclization across a medium-sized ring delivers previously unattainable twisted amides from simple acyclic precursors.
authors.affiliation: Department of Medicinal Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Malott Hall, Room 4070, Lawrence, Kansas 66045-7852, USA.
authors.forename: Michal
authors.initials: M
authors.lastname: Szostak
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Aubé
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D006572:Heterocyclic Compounds, Bridged-Ring / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
chemical_list: D000577:Amides; D006572:Heterocyclic Compounds, Bridged-Ring