[The role of celiac disease and type 1 diabetes coexistance. Is celiac disease responsible for diabetic status?].
Celiac disease is the status of the autoimmune answer provoked by gluten ingestion in genetically predisposed people. Recently gluten entheropathy was considered as a rare clinical problem in adults. Celiac disease is an autoimmune disorder that can coexist with other diseases, such as diabetes mellitus type 1 (DMID), thyroid gland diseases. The aim of our study was evaluation of the frequency of coexistence of celiac disease with DMID using the level of anti tissue transglutaminase antibodies (IgA- tTG) and mucosal biopsy from the distal part of the duodenum. An attempt was made to estimate the influence of celiac disease on the intensity of clinical symptoms and metabolic balance in patients with DMID. Our study included 109 patients with DMID, aged 18-52 years. The frequency of the incidence of celiac disease in DMID patients was 9.71%. Gastric symptoms, such as diarrhea, abdominal pain were more frequent in patients with villous atrophy in the intestine. Hyperglycemia and problems with glucose balance in the serum were observed. Introduction of the gluten free diet led to improvement quality of life, less frequent hypoglycemic episodes and disappearance of diarrhea, increase of serum iron and decrease of IgA-tTG level in the serum. It is necessary to measure the level of IgA- tTG in patients with DMID. Diagnosis of celiac disease in patients with DMID and its treatment with gluten free diet causes the clinical, histological and biochemical improvement in these patients.
Galicka-Latała
Danuta
D
Katedra i Klinika Chorób Metabolicznych, Uniwersytet Jagielloński, Collegium Medicum, Kraków. dlatala@cm-uj.krakow.pl
Zwolińska-Wcisło
Małgorzata
M
Sosin-Rudnicka
Lucyna
L
Rozpondek
Piotr
P
D000293:Adolescent; D000328:Adult; D015984:Causality; D002446:Celiac Disease / Q000178:diet therapy / Q000453:epidemiology*; D002648:Child; D015897:Comorbidity; D003922:Diabetes Mellitus, Type 1 / Q000453:epidemiology*; D055050:Diet, Gluten-Free; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011503:Transglutaminases / Q000276:immunology; D055815:Young Adult
D007070:Immunoglobulin A; D011503:Transglutaminases