Shape and release control of a peptide decorated vesicle through pH sensitive orthogonal supramolecular interactions.
A pH sensitive carrier is obtained by coating a cyclodextrin vesicle with an adamantane-terminated octapeptide through the formation of an inclusion complex. Upon lowering the pH from 7.4 to 5.0, the formation of peptide beta-sheets on the vesicle surface induces a transition of the bilayer from a sphere to a fiber. This transition is fully reversible and repeatable. The vesicles release their cargo upon fiber formation.
Versluis
Frank
F
Leiden Institute of Chemistry, University Leiden, P.O. Box 9502, 2300 RA, Leiden, The Netherlands.
Tomatsu
Itsuro
I
Kehr
Seda
S
Fregonese
Carlo
C
Tepper
Armand W J W
AW
Stuart
Marc C A
MC
Ravoo
Bart Jan
BJ
Koning
Roman I
RI
Kros
Alexander
A
D002942:Circular Dichroism; D003505:Cyclodextrins / Q000737:chemistry; D005456:Fluorescent Dyes / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D008567:Membranes, Artificial; D009842:Oligopeptides / Q000737:chemistry*; D017433:Protein Structure, Secondary; D013499:Surface Properties
D003505:Cyclodextrins; D005456:Fluorescent Dyes; D008567:Membranes, Artificial; D009842:Oligopeptides