Two new cerebrosides from the pollen of Typha angustifolia.
Two new cerebrosides, 1-O-(beta-d-glucopyranosyloxy)-(2S,3S,4R,8Z)-2-[(2'R)-2'-hydroxytricosanoylamino]-8-nonadecene-3,4-diol (1) and 1-O-(beta-D-glucopyranosyloxy)-(2S,3R,4E,8Z)-2-[(2'R)-2'-hydroxynonadecanoylamino]-4,13-nonadecene-3-diol (2), were isolated from the pollen of Typha angustifolia. Their structures were elucidated by chemical and spectral means. This is the first report on the occurrence of cerebroside in Typha (Typhaceae). Compounds 1 and 2 exhibited effect on the proliferation of cultured vascular smooth muscle cell (VSMCs) induced by fatal bovine serum (FBS).
Tao
Wei-Wei
WW
Jiangsu Key Laboratory for TCM Formulae Research, Nanjing University of Chinese Medicine, Nanjing, China.
Yang
Nian-Yun
NY
Liu
Li
L
Duan
Jin-Ao
JA
Wu
De-Kang
DK
Qian
Da-Wei
DW
Tang
Yu-Ping
YP
D000818:Animals; D001161:Arteriosclerosis / Q000517:prevention & control; D002317:Cardiovascular Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002417:Cattle; D049109:Cell Proliferation / Q000187:drug effects; D002554:Cerebrosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D042783:Endothelial Cells / Q000187:drug effects; D004730:Endothelium, Vascular / Q000187:drug effects*; D005963:Glucosylceramides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D011058:Pollen / Q000737:chemistry; D032401:Typhaceae / Q000737:chemistry*
C551162:1-O-(glucopyranosyloxy)-2-(2'-hydroxynonadecanoylamino)-4,13-nonadecene-3-diol; C551161:1-O-(glucopyranosyloxy)-2-(2'-hydroxytricosanoylamino)-8-nonadecene-3,4-diol; D002317:Cardiovascular Agents; D002554:Cerebrosides; D005963:Glucosylceramides; D010936:Plant Extracts