The association between cardiac calcification and coronary artery disease.
OBJECTIVE
The objective of this study was to determine whether there is an association between mitral annular calcification (MAC), aortic valve annulus calcification (AVAC) and aortic valve calcification (AVC) with coronary artery disease (CAD) in subjects < or =65 years.


METHODS
386 patients under 65 years of age underwent transthoracic echocardiography and coronary arteriography at the same time.


RESULTS
The following results were obtained: (I) The patients with calcium deposits were older than the patients without calcium deposits (P < 0.01). Hypertension (P < 0.05) and diabetes mellitus (P < 0.001) were significantly associated with MAC. Hypertension (P < 0.01), diabetes mellitus (P < 0.05) and a smoking history (P < 0.05) were significantly more prevalent in patients with AVC than in those without AVC. Hypertension was significantly more frequent in patients with AVAC (P < 0.05). (II) There was a positive correlation between age (P < 0.001), hypertension (P < 0.001), diabetes (P < 0.05) and the number of sites with calcium deposits. (III) Coronary arteriography was more frequently positive in patients with calcium deposits than in those without (P < 0.01). (IV) Multivariable logistic regression analysis identified multiple calcium deposits (P < 0.01), age (P < 0.05), male gender (P < 0.001), diabetes mellitus (P < 0.001), and hypercholesterolaemia (P < 0.05) as significant predictors for a positive coronary arteriography. Multiple calcium deposits (P < 0.001) and diabetes mellitus (P < 0.001) were also significant predictors in female patients. In patients aged < or =55 years, multiple calcium deposits (P < 0.05), diabetes mellitus (P <0.05), smoking history (P < 0.05) and male gender (P < 0.05) were statistically significant predictors of a positive coronary arteriography.


CONCLUSIONS
There is a significant association between the presence of calcium deposits and coronary artery disease. The presence of multiple calcium deposits is an independent predictor of coronary artery disease.
Chu
Honggang
H
Department of Ultrasound, Renmin Hospital, Wuhan University, Wuhan 430060, China. chg121@163.com
Chen
Jinling
J
Guo
Ruiqiang
R
D000328:Adult; D000367:Age Factors; D000368:Aged; D001021:Aortic Valve / Q000473:pathology; D002114:Calcinosis; D017023:Coronary Angiography; D003327:Coronary Disease / Q000473:pathology*; D003920:Diabetes Mellitus / Q000473:pathology; D004452:Echocardiography; D005260:Female; D006351:Heart Valves / Q000473:pathology*; D006801:Humans; D006937:Hypercholesterolemia / Q000473:pathology; D006973:Hypertension / Q000473:pathology; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000473:pathology; D012737:Sex Factors