Phytochemical analyses and gastroprotective effects of Eugenia umbelliflora (Myrtaceae) on experimental gastric ulcers.
Phytochemical studies of Eugenia umbelliflora Berg. (Myrtaceae) resulted in the isolation of: taraxerol, alpha-amyrin, beta-amyrin, betulin and betulinic acid from the leaves, as well as trimethoxy ellagic acid from the fruits. Given that several triterpenes were found in the extracts, and that these possess gastroprotective activity, the gastroprotective activity of E. umbelliflora leaf extract was evaluated using ethanol, indomethacin, and stress-induced ulcer models in mice. The crude methanol extract was administrated (v.o) in doses of 50, 125 and 250 mg/kg. The results showed that E. umbelliflora leaves display gastro-protective activity, as demonstrated by significant inhibition of ulcer formation in the different models. The results suggest that the gastroprotective activity may be attributed, at least in part, to the triterpenes.
Meyre-Silva
Christiane
C
Núcleo de Investigações Químico-Farmacêuticas, Universidade do Vale do Itajaí-UNIVALI, 88302-202, Itajai, Santa Catarina, Brazil. cmeyre@univali.br
Petry
Cristiane Maes
CM
Berté
Talita Elisa
TE
Becker
Renan Gandolfi
RG
Zanatta
Francielle
F
Delle-Monache
Franco
F
Cechinel-Filho
Valdir
V
Andrade
Sérgio Faloni
SF
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000897:Anti-Ulcer Agents / Q000737:chemistry* / Q000494:pharmacology*; D002492:Central Nervous System Depressants; D018678:Cholinergic Agents / Q000494:pharmacology; D002855:Chromatography, Thin Layer; D002927:Cimetidine / Q000494:pharmacology; D003080:Cold Temperature; D000431:Ethanol; D005638:Fruit / Q000737:chemistry; D007213:Indomethacin; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009853:Omeprazole / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D012149:Restraint, Physical; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control*; D013315:Stress, Psychological / Q000150:complications; D027842:Syzygium / Q000737:chemistry*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000897:Anti-Ulcer Agents; D002492:Central Nervous System Depressants; D018678:Cholinergic Agents; D010936:Plant Extracts; D000431:Ethanol; D002927:Cimetidine; D009853:Omeprazole; D007213:Indomethacin