Renoprotective effects of Andrographis paniculata (Burm. f.) Nees in rats.
BACKGROUND
Renal failure is an increasingly common condition with limited treatment options that is causing a major financial and emotional burden on the community. Andrographis paniculata is the plant used in Ayurveda for several remedies. Scientific evidence suggests its versatile biological functions that support its traditional use in the Orient. The plant is claimed to possess immunological, antibacterial, anti-inflammatory, antithrombotic, and hepatoprotective properties. But, to date, there is no study demonstrating the protective effect of A. paniculata on gentamicin-induced renal failure. The present study aims to highlight the first ever reported, antirenal failure activity of A. paniculata.


METHODS
Male Wistar albino rats were divided into three groups: normal control, gentamicin control, and aqueous extract of A. paniculata (200 mg/kg, per oral (p.o.))-treated. The nephrotoxic model was induced by gentamicin (80 mg/kg, intraperitoeal (i.p.)). Blood samples were examined for serum creatinine, serum urea, and blood urea nitrogen after the 10 days of treatment.


RESULTS
A gentamicin-induced nephrotoxic animal model was successfully prepared. Aqueous extract of A. paniculata attenuated the gentamicin-induced increase in serum creatinine, serum urea, and blood urea nitrogen levels by 176.92%, 106.27%, and 202.90%, respectively.


CONCLUSIONS
The present study reports that the aqueous extract (whole plant) of A. paniculata (Burm. f.) Nees exhibits a significant renoprotective effect in gentamicin-induced nephrotoxicity in male Wistar albino rats.
Singh
Pratibha
P
Department of Chemistry, Dayalbagh Educational Institute (Deemed University), Agra, India.
Srivastava
Man Mohan
MM
Khemani
Lakhu Dev
LD
D035685:Andrographis / Q000737:chemistry*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000633:toxicity; D001806:Blood Urea Nitrogen; D005839:Gentamicins / Q000633:toxicity; D007668:Kidney / Q000187:drug effects*; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D051437:Renal Insufficiency / Q000139:chemically induced
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D010936:Plant Extracts