Enlightened protein: Fhit tumor suppressor protein structure and function and its role in the toxicity of protoporphyrin IX-mediated photodynamic reaction.
The Fhit tumor suppressor protein possesses Ap(3)A (diadenosine triphosphate - ApppA) hydrolytic activity in vitro and its gene is found inactive in many pre-malignant states due to gene inactivation. For several years Fhit has been a widely investigated protein as its cellular function still remains largely unsolved. Fhit was shown to act as a molecular 'switch' of cell death via cascade operating on the influence of ATR-Chk1 pathway but also through the mitochondrial apoptotic pathway. Notably, Fhit was reported by our group to enhance the overall eradication effect of porphyrin-mediated photodynamic treatment (PDT). In this review the up-to-date findings on Fhit protein as a tumor suppressor and its role in PDT are presented.
Zawacka-Pankau
Joanna
J
Department of Biotechnology, Division of Molecular Diagnostics, Intercollegiate Faculty of Biotechnology, University of Gdansk and Medical University of Gdansk, Kladki 24, 80-822 Gdansk, Poland. jzawacka@biotech.ug.gda.pl
Ferens
Bartosz
B
D017766:Acid Anhydride Hydrolases / Q000235:genetics / Q000502:physiology*; D000818:Animals; D017209:Apoptosis; D015226:Dinucleoside Phosphates / Q000378:metabolism; D020868:Gene Silencing; D006801:Humans; D009363:Neoplasm Proteins / Q000235:genetics / Q000502:physiology*; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism / Q000628:therapy; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000494:pharmacology* / Q000627:therapeutic use; D011487:Protein Conformation; D011524:Protoporphyrins / Q000494:pharmacology* / Q000627:therapeutic use; D000099170:Bis(5'-adenosyl)triphosphatase
D017766:Acid Anhydride Hydrolases; D015226:Dinucleoside Phosphates; D009363:Neoplasm Proteins; D017319:Photosensitizing Agents; D011524:Protoporphyrins; D000099170:Bis(5'-adenosyl)triphosphatase; C011440:diadenosine triphosphate; C028025:protoporphyrin IX