title: Frontal-striatal abnormalities underlying behaviours in the compulsive-impulsive spectrum.
abstract: In this paper, we tentatively bring together the psychiatric, neurological and addiction perspectives on the impulsive-compulsive spectrum of neuropsychiatric disorders, in order to understand the pathophysiology of impulse control disorders (ICDs) in Parkinson's disease. In an attempt to try to pool the various levels of information we will therefore focus on three disorders within the impulse-compulsive spectrum, i.e., obsessive-compulsive disorder (OCD), ICDs in Parkinson's disease, and cocaine seeking behaviour. Whereas there are large differences between these three domains, each with their own nomenclature, hypotheses and study results, they share the focus on an imbalance within and between the frontal-striatal circuits as underlying substrate for the behaviours. For each disorder, we summarize the results from recent studies in order to describe in which way alterations in the frontal-striatal circuits contribute to the phenotype. The phenomenological overlap between ICDs in Parkinson's disease, addiction and OCD needs further investigation, since better understanding of the overlapping and differentiating characteristics will contribute to our understanding of the pathophysiology of the disturbances and treatment alternatives.
authors.affiliation: Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands. OA.vandenHeuvel@vumc.nl
authors.forename: Odile A
authors.initials: OA
authors.lastname: van den Heuvel
authors.forename: Ysbrand D
authors.initials: YD
authors.lastname: van der Werf
authors.forename: Kim M W
authors.initials: KM
authors.lastname: Verhoef
authors.forename: Stella
authors.initials: S
authors.lastname: de Wit
authors.forename: Henk W
authors.initials: HW
authors.lastname: Berendse
authors.forename: Erik Ch
authors.initials: ECh
authors.lastname: Wolters
authors.forename: Dick J
authors.initials: DJ
authors.lastname: Veltman
authors.forename: Henk J
authors.initials: HJ
authors.lastname: Groenewegen
mesh_terms: D019970:Cocaine-Related Disorders / Q000473:pathology; D003192:Compulsive Behavior / Q000473:pathology*; D003342:Corpus Striatum / Q000473:pathology*; D005625:Frontal Lobe / Q000473:pathology*; D006801:Humans; D008954:Models, Biological; D009434:Neural Pathways / Q000473:pathology; D010300:Parkinson Disease / Q000150:complications