Lineage commitment: cytokines instruct, at last!
Instructive and permissive models of commitment have been proposed for hematopoietic cytokines. In recent issues of Science and Cell, Rieger et al. (2009) and Sarrazin et al. (2009) together show that cytokines can instruct lineage choice.
Stanley
E Richard
ER
Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. rstanley@aecom.yu.edu
D000818:Animals; D002454:Cell Differentiation; D019070:Cell Lineage; D016207:Cytokines / Q000378:metabolism*; D006801:Humans; D051258:MafB Transcription Factor / Q000378:metabolism; D051379:Mice; D008954:Models, Biological; D039902:Multipotent Stem Cells / Q000166:cytology / Q000378:metabolism
D016207:Cytokines; D051258:MafB Transcription Factor