title: Pathogen recognition by DC-SIGN shapes adaptive immunity.
abstract: Dendritic cells (DCs) tailor adaptive immune responses to specific pathogens. This diversity is mediated by cooperation between different pattern recognition receptors that are triggered by specific pathogens. DC-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN) is a pattern recognition receptor with a broad pathogen recognition specificity as a result of its affinity for mannose and fucose carbohydrates. DC-SIGN induces very diverse immune responses to different pathogens, such as bacteria, fungi, helminths and viruses. Recent data show that DC-SIGN triggering by pathogens modulates Toll-like receptor signaling at the level of nuclear factor-kappaB. In this article, we will discuss the signaling pathways induced by DC-SIGN and its central role in the regulation of adaptive immunity to bacterial, fungal and viral pathogens.
authors.affiliation: Department of Molecular Cell Biology & Immunology, VU University Medical Center, 1007 MC Amsterdam, The Netherlands. t.b.geijtenbeek@amc.uva.nl
authors.forename: Teunis B H
authors.initials: TB
authors.lastname: Geijtenbeek
authors.forename: Jeroen
authors.initials: J
authors.lastname: den Dunnen
authors.forename: Sonja I
authors.initials: SI
authors.lastname: Gringhuis
mesh_terms: D000818:Animals; D001419:Bacteria / Q000276:immunology; D015815:Cell Adhesion Molecules / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology*; D005658:Fungi / Q000276:immunology; D006376:Helminths / Q000276:immunology; D006801:Humans; D037181:Lectins, C-Type / Q000276:immunology*; D008954:Models, Biological; D011956:Receptors, Cell Surface / Q000276:immunology*; D015398:Signal Transduction; D014780:Viruses / Q000276:immunology; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin
chemical_list: D015815:Cell Adhesion Molecules; D037181:Lectins, C-Type; D011956:Receptors, Cell Surface; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin