title: Four-component domino reaction leading to multifunctionalized quinazolines.
abstract: A new four-component domino reaction has been discovered. The reaction is easy to perform simply by mixing four common reactants and K(2)CO(3) in ethylene glycol under microwave irradiation. The reaction proceeds rapidly and can be finished within 10-24 min with water as the major byproduct, making workup convenient. Four stereogenic centers with one quaternary carbon-amino function are controlled very well; the stereochemistry was unequivocally determined by X-ray structural analysis. The resulting pyrido[3,4-i]quinazoline derivatives are of importance for organic and medicinal research.
authors.affiliation: School of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou 221116, Jiangsu, PR China.
authors.forename: Bo
authors.initials: B
authors.lastname: Jiang
authors.forename: Shu-Jiang
authors.initials: SJ
authors.lastname: Tu
authors.forename: Parminder
authors.initials: P
authors.lastname: Kaur
authors.forename: Walter
authors.initials: W
authors.lastname: Wever
authors.forename: Guigen
authors.initials: G
authors.lastname: Li
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000577:Amides / Q000737:chemistry; D018360:Crystallography, X-Ray; D055772:Green Chemistry Technology; D007659:Ketones / Q000737:chemistry; D008872:Microwaves; D011799:Quinazolines / Q000737:chemistry*; D013379:Substrate Specificity
chemical_list: D000447:Aldehydes; D000577:Amides; D007659:Ketones; D011799:Quinazolines