title: [Protease-resistant prion protein (PrPres) in the blood of offspring of cows that developed BSE].
abstract: The goal of the present study was to investigate whether protease-resistant prion protein (PrPres) occurs in plasma samples of offspring of cows that developed bovine spongiform encephalopathy (BSE; group A) and to compare the prevalence with that of a healthy control group in 2006 (Group B). Group A consisted of 181 offspring of cows that developed BSE and group B consisted of 240 healthy animals from a region in Switzerland where no cases of BSE occurred from 2001 to the end of 2006. All plasma samples were evaluated using Alicon PrioTrap, an antemortem test for PrPres. The time between birth of the offspring and onset of BSE in the dam was calculated to determine its relationship with the presence of PrPres in the plasma of the offspring. From 181 offspring, 29 (16.1%) had PrPres-positive plasma samples. Offspring that were born within one year of the onset of BSE in the dam had a significantly higher prevalence of PrPres-positive plasma samples than those born more than one year before the onset of BSE in the dam. Ten (4.2%) of 240 control cattle had PrPres-positive plasma samples. Thus, PrPres can be detected in bovine blood and occurs more frequently in the offspring of cows that develop BSE than in cattle of a healthy control population.
authors.affiliation: Departement für Nutztiere der Universität Zürich. ubraun@vetclinics.uzh.ch
authors.forename: U
authors.initials: U
authors.lastname: Braun
authors.forename: A
authors.initials: A
authors.lastname: Tschuor
authors.forename: M
authors.initials: M
authors.lastname: Hässig
authors.forename: S
authors.initials: S
authors.lastname: Franitza
authors.forename: E
authors.initials: E
authors.lastname: Berli
authors.forename: A
authors.initials: A
authors.lastname: El Gedaily
authors.forename: N
authors.initials: N
authors.lastname: Franscini
authors.forename: U
authors.initials: U
authors.lastname: Matthey
authors.forename: R
authors.initials: R
authors.lastname: Zahn
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D002417:Cattle; D018562:Disease Transmission, Infectious / Q000662:veterinary; D016643:Encephalopathy, Bovine Spongiform / Q000097:blood* / Q000188:drug therapy / Q000635:transmission; D005260:Female; D018445:Infectious Disease Transmission, Vertical / Q000662:veterinary; D008297:Male; D010447:Peptide Hydrolases / Q000494:pharmacology*; D018620:PrPSc Proteins / Q000187:drug effects* / Q000378:metabolism / Q000472:pathogenicity; D017096:Prion Diseases / Q000097:blood / Q000188:drug therapy / Q000635:transmission / Q000662:veterinary*
chemical_list: D018620:PrPSc Proteins; D010447:Peptide Hydrolases