Papular mycosis fungoides: two new cases of a recently described clinicopathological variant of early mycosis fungoides.
BACKGROUND
Mycosis fungoides (MF) is the most common type of cutaneous T-cell lymphoma. In early stages of the disease many different clinicopathologic variants have been observed. Currently, a papular variant of MF which is characterized by a good prognosis has been described.


OBJECTIVE
Because only seven cases have been reported in the literature, clinical and morphological data of this variant are not well established. We report the clinical and histopathological characteristics of two new patients with papular mycosis fungoides and review the previous cases reported in the literature.


RESULTS
The two cases of this early variant of MF were characterized by the presence of papules which, unlike the papules of lymphomatoid papulosis, did not show a tendency for spontaneous resolution. Histologic examination confirmed the diagnosis of MF in all cases. Immunohistochemical staining for CD30 was negative in all two cases. Follow-up data of our two patients confirmed the non-aggressive behavior of the disease, confirming that the lesions were not manifestations of advanced MF.


CONCLUSIONS
Papular MF is a new variant of early MF characterized by a good prognosis in the long term follow- up. Thus, it should be added to the long list of clinicopathologic subtypes of MF.
Martorell-Calatayud
Antonio
A
Dermatology Department, Fundación Instituto Valenciano de Oncología, Valencia, Spain. antmarto@hotmail.com
Botella-Estrada
Rafael
R
Sanmartín-Jimenez
Onofre
O
Requena
Celia
C
Guillén-Barona
Carlos
C
Sangüeza
Omar Pastor
OP
D002990:Clobetasol / Q000627:therapeutic use; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000188:drug therapy / Q000473:pathology*; D011701:PUVA Therapy; D012878:Skin Neoplasms / Q000188:drug therapy / Q000473:pathology*; D016896:Treatment Outcome
D005938:Glucocorticoids; D002990:Clobetasol