title: Massive choroidal hemorrhage after intravitreal administration of bevacizumab (Avastin) for AMD followed by controlateral sympathetic ophthalmia.
abstract: OBJECTIVE
  To report a severe ocular complication initiated ten days after intravitreal administration of bevacizumab (Avastin((R))), in a patient with exudative age-related macular degeneration (AMD).
  
  
  METHODS
  Case report.
  
  
  RESULTS
  Ten days after intravitreal injection of 1.25 mg Avastin((R)), the patient manifested acute loss of vision with excruciating pain. An extensive choroidal detachment was evident in close contact with the lens, which necessitated an emergency sclerotomy with reconstruction of the anterior chamber. Four months later, the eye proceeded to phthisis bulbi. Five months after the injection, the patient complained of mild pain, photophobia, and visual acuity deterioration from the fellow eye. The diagnosis of sympathetic ophthalmia was suggested and treated with intravitreal injections of triamcinolone acetonide every three months with good response, complicated by elevation of intraocular pressure which we managed with Ahmet valve implantation.
  
  
  CONCLUSIONS
  Serious ocular complications after intravitreal of Avastin((R)) can not be excluded, including massive choroidal hemorrhage and sympathetic ophthalmia of the fellow eye.
authors.affiliation: 1st Eye Department, University of Athens, Athens, Greece.
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Brouzas
authors.forename: Chryssanthi
authors.initials: C
authors.lastname: Koutsandrea
authors.forename: Marilita
authors.initials: M
authors.lastname: Moschos
authors.forename: Spiros
authors.initials: S
authors.lastname: Papadimitriou
authors.forename: Ioannis
authors.initials: I
authors.lastname: Ladas
authors.forename: Michael
authors.initials: M
authors.lastname: Apostolopoulos