title: Advancing age leads to predominance of inhibitory receptor expressing CD4 T cells.
abstract: Decline in CD4 T cell function is the hallmark of aging. In this study, we compared the proportion and absolute number of inhibitory receptor expressing splenic CD4 T cells in unprimed young (2 months) and aged (20 months) C57BL/6 mice. Our results showed a predominance of PD-1, ICOS and CTLA-4 expressing conventional and regulatory CD4 T cells in aged mice. Furthermore, the expression of these molecules was localized to memory but not naïve CD4 T cell subset. Since aging is associated with decline in naïve but accumulation of hyporesponsive memory phenotype (MP) CD4 T cell, we hypothesize that inhibitory receptors can account for the senescence noted in MP subset of CD4 T cell.
authors.affiliation: Department of Biology, College of Arts and Sciences, Oakland University, Rochester, MI 48309-4401, USA.
authors.forename: Rudragouda
authors.initials: R
authors.lastname: Channappanavar
authors.forename: Brandon S
authors.initials: BS
authors.lastname: Twardy
authors.forename: Pratima
authors.initials: P
authors.lastname: Krishna
authors.forename: Susmit
authors.initials: S
authors.lastname: Suvas
mesh_terms: D000367:Age Factors; D000375:Aging / Q000276:immunology*; D000818:Animals; D015703:Antigens, CD / Q000378:metabolism; D000943:Antigens, Differentiation / Q000378:metabolism; D000945:Antigens, Differentiation, T-Lymphocyte / Q000378:metabolism; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D060908:CTLA-4 Antigen; D007108:Immune Tolerance; D007156:Immunologic Memory; D060889:Inducible T-Cell Co-Stimulator Protein; D051379:Mice; D008810:Mice, Inbred C57BL; D061026:Programmed Cell Death 1 Receptor; D013154:Spleen / Q000166:cytology / Q000276:immunology*
chemical_list: D015703:Antigens, CD; D000943:Antigens, Differentiation; D000945:Antigens, Differentiation, T-Lymphocyte; D060908:CTLA-4 Antigen; C556707:Ctla4 protein, mouse; C556694:Icos protein, mouse; D060889:Inducible T-Cell Co-Stimulator Protein; C491383:Pdcd1 protein, mouse; D061026:Programmed Cell Death 1 Receptor