Transfer hydrogenation in water: enantioselective, catalytic reduction of (E)-beta,beta-disubstituted nitroalkenes.
A mild catalytic asymmetric transfer hydrogenation of beta,beta-disubstituted nitroalkenes is reported. Formic acid is used as a reductant in combination with an Ir catalyst. The reaction is conducted in water at low pH and open to air to give adducts in preparatively useful yield and selectivity.
Soltani
Omid
O
Laboratorium für Organische Chemie, ETH Zürich, HCI H335, Switzerland.
Ariger
Martin A
MA
Carreira
Erick M
EM