title: Clinical evidence of the antiarrhythmic effect of a magistral suspension of propafenone: a case report.
abstract: Propafenone is an antiarrhythmic that has been used for the treatment of tachiarrytmias in both adults and children. The aim of this study was to analyze the pharmacologic effect of a magistral suspension of propafenone, due to lack of an adequate commercial formulation for use in children. In this study we present, a case of a 2-year-old boy that was diagnosed with Wolff-Parkinson White syndrome and treated with a magistral suspension of propafenone. He has now been one year with no symptoms, no tachycardia and no cyanosis. The clinical status of the patient under treatment with propafenone was improved through constant medical care in the Cardiological Health Care Unit. The use of a magistral formulation of propafenone developed in our laboratory offers a temporal solution due to lack of medicines for children.
authors.affiliation: Laboratorio de Farmacología, Instituto Nacional de Pediatría (INP), México, D.F. México.
authors.forename: Lina
authors.initials: L
authors.lastname: Barranco-Garduño
authors.forename: Janett
authors.initials: J
authors.lastname: Flores-Pérez
authors.forename: Hugo
authors.initials: H
authors.lastname: Juárez-Olguín
authors.forename: Jesús
authors.initials: J
authors.lastname: Bobadilla-Chávez
authors.forename: Héctor
authors.initials: H
authors.lastname: Osnaya
authors.forename: Carmen
authors.initials: C
authors.lastname: Flores-Pérez
mesh_terms: D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000188:drug therapy*; D002675:Child, Preschool; D006801:Humans; D008297:Male; D011405:Propafenone / Q000627:therapeutic use*; D013535:Suspensions
chemical_list: D000889:Anti-Arrhythmia Agents; D013535:Suspensions; D011405:Propafenone