Targeting autophagy to prevent neonatal stroke damage.
Cell death due to cerebral ischemia has been attributed to necrosis and apoptosis, but autophagic mechanisms have recently been implicated as well. Using rats exposed to neonatal focal cerebral ischemia, we have shown that lysosomal and autophagic activities are increased in ischemic neurons, and have obtained strong neuroprotection by post-ischemic inhibition of autophagy.
Puyal
Julien
J
Département de Biologie Cellulaire et de Morphologie, University of Lausanne, Lausanne, Switzerland. JulienPierre.Puyal@unil.ch
Clarke
Peter G H
PG
D000818:Animals; D000831:Animals, Newborn; D001343:Autophagy / Q000502:physiology*; D002545:Brain Ischemia / Q000473:pathology / Q000503:physiopathology; D016923:Cell Death / Q000502:physiology; D008247:Lysosomes / Q000378:metabolism; D009474:Neurons / Q000378:metabolism; D051381:Rats