Macroscopic Borrmann type as a simple prognostic indicator in patients with advanced gastric cancer.
BACKGROUND
The purpose of this study was to clarify the clinical significance of macroscopic Borrmann type in advanced gastric cancer.


METHODS
From 1987 to 2001, we retrospectively studied the clinicopathological features and prognoses of 3,966 patients with advanced gastric cancer according to the macroscopic classification of Borrmann type.


RESULTS
Multivariate analysis showed that gender, Borrmann type and depth of invasion were all associated with the status of nodal involvement. There were statistically significant differences in overall survival among patients with Borrmann type I and II tumors, Borrmann type III tumors, and Borrmann type IV tumors according to depth of invasion (pT) and nodal involvement (pN), except in pN3 tumors. Borrmann type was an independent prognostic factor in patients with advanced gastric cancer. Furthermore, the 5-year survival rates of patients with Borrmann type III and type IV tumors after curative resection were 62.0 and 51.2%, respectively; this was significantly higher than after noncurative resection (17.8 and 18.0%, respectively).


CONCLUSIONS
Macroscopic Borrmann type is a simple and valuable predictor for lymph node metastasis and survival in advanced gastric cancer patients.
Li
Chen
C
Department of Surgery, Yonsei University College of Medicine, Seoul, Korea.
Oh
Sung Jin
SJ
Kim
Sungsoo
S
Hyung
Woo Jin
WJ
Yan
Min
M
Zhu
Zheng Gang
ZG
Noh
Sung Hoon
SH
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D013274:Stomach Neoplasms / Q000401:mortality / Q000473:pathology*; D015996:Survival Rate