Biomarkers in fibromyalgia.
Fibromyalgia is a common pain syndrome characterized by widespread pain, tenderness, and a number of other somatic symptoms and syndromes. Although there was original skepticism that any objective abnormalities would be identified in these individuals, at present there are many that have been reproducibly identified, and most point to dysregulation of central nervous system function as a key underlying pathogenic mechanism in this and related illnesses. This article reviews several objective abnormalities or measures that have been identified or used in fibromyalgia, and indicates which of these may be most promising to eventually use as biomarkers to follow the response to treatment or progress of disease over time.
Ablin
Jacob N
JN
University of Michigan Chronic Pain and Fatigue Research Center, Ann Arbor, MI 48106, USA.
Buskila
Dan
D
Clauw
Daniel J
DJ
D015415:Biomarkers / Q000378:metabolism; D005356:Fibromyalgia / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism*; D005819:Genetic Markers / Q000235:genetics; D006801:Humans; D010147:Pain Measurement / Q000379:methods
D015415:Biomarkers; D005819:Genetic Markers