[Toxicity estimation of unspecific medicinal antiviral agents for prophylaxis and therapy of hazard and especially hazard viral infections].
Cytotoxicity of chemotherapeutics (Ribavirin, Remantadin and Ingavirin), interferon (Realdiron) and interferon inductors (Larifan, Ridostin, Arbidol and Cytarabin) was investigated with the use of persistent and diploid cell cultures. Ingavirin and Ribavirin from the group of the chemotherapeutics and Razifan and Ridostin from the group of the interferon inducrors showed the lowest toxicity. Light microscopy revealed no visible cytopathic changes in the investigation cell cultures exposed to maximum concentrations (> or =10(6) IU) of Realdiron. In vivo acute toxicity investigation demonstrated that in a concentration of 10(6) IU per animal weight Realdiron was not toxic for the albino mice and chinchilla rabbits. The maximum tolerance doses for the albino mice were the following: > or =3000 mg/kg of Ingavirin, 401.25 mg/kg of Arbidol, 170 mg/kg of Ribavirin, > or =100 mg/kg of Larifan and > or =100 mg/kg of Ridostin.
Loginova
S Ia
SIa
Borisevich
S V
SV
Maksimov
V A
VA
Bondarev
V P
VP
D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use / Q000633:toxicity*; D002460:Cell Line; D006801:Humans; D007369:Interferon Inducers / Q000627:therapeutic use / Q000633:toxicity*; D051379:Mice; D011817:Rabbits; D014777:Virus Diseases / Q000188:drug therapy* / Q000517:prevention & control
D000998:Antiviral Agents; D007369:Interferon Inducers