title: Synthesis and anticancer activity of novel 3,4-diarylthiazol-2(3H)-ones (imines).
abstract: A series of 3,4-diarylthiazol-2(3H)-ones and three 3,4-diarylthiazol-2(3H)-imines were synthesized and evaluated for their cytotoxicity in a panel of human cancer cell lines. Compounds 21 and 22 showed potential anticancer activity against human CEM cells with IC50 values of 0.12 and 0.24microM, respectively.
authors.affiliation: Department of Chemistry, Georgia State University, Atlanta, GA 30303-3083, USA.
authors.forename: Zong-Ying
authors.initials: ZY
authors.lastname: Liu
authors.forename: Yue-Ming
authors.initials: YM
authors.lastname: Wang
authors.forename: Zhuo-Rong
authors.initials: ZR
authors.lastname: Li
authors.forename: Jian-Dong
authors.initials: JD
authors.lastname: Jiang
authors.forename: David W
authors.initials: DW
authors.lastname: Boykin
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007097:Imines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013844:Thiazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity
chemical_list: D000970:Antineoplastic Agents; D007097:Imines; D013844:Thiazoles