[Expression of aquaporin-1 in human oligohydramnios placenta and fetal membranes].
OBJECTIVE
To detect aquaporin-1 mRNA (AQP1) expression in human oligohydramnios placenta and fetal membranes.


METHODS
Placenta and fetal membranes samples were obtained from 5 women with oligohydramnios and 5 with normal amniotic fluid volume. AQP-1 mRNA expression in the tissue samples was detected by semi-quantitative RT-PCR.


RESULTS
The expression of AQP1 mRNA was significantly lower in oligohydramnios placenta than in normal pregnancy placenta at term (P<0.05), and also significantly lower in oligohydramnios fetal membranes than in normal fetal membranes at term (P<0.05).


CONCLUSIONS
Alterations in AQP1 mRNA expressions in human placenta and fetal membranes may play an important role in the disorder of maternal-fetal fluid exchange and amniotic fluid volume.
Hao
Rong-Zeng
RZ
Department of Obstetrics and Gynecology, Third Affiliated Hospital of Guangzhou Medical College, Guangzhou, China. haorongzeng@163.com
Liu
Hui-Shu
HS
Xiong
Zheng-Fang
ZF
D000328:Adult; D051398:Aquaporin 1 / Q000235:genetics / Q000378:metabolism*; D005321:Extraembryonic Membranes / Q000378:metabolism*; D005260:Female; D006801:Humans; D016104:Oligohydramnios / Q000378:metabolism*; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D055815:Young Adult
C496020:AQP1 protein, human; D012333:RNA, Messenger; D051398:Aquaporin 1