title: Bile acids have the gall to function as hormones.
abstract: In this issue of Cell Metabolism, Thomas et al. (2009) show that specific activation of the bile-acid-activated G protein-coupled receptor TGR5 improves pancreatic and hepatic function and impairs the development of obesity following administration of a high-fat diet.
authors.affiliation: Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, BSRB Room 310, Los Angeles, CA 90095, USA.
authors.forename: Thomas Quad de Aguiar
authors.initials: TQ
authors.lastname: Vallim
authors.forename: Peter A
authors.initials: PA
authors.lastname: Edwards
mesh_terms: D000818:Animals; D001647:Bile Acids and Salts / Q000378:metabolism*; D019858:Enteroendocrine Cells / Q000378:metabolism; D052216:Glucagon-Like Peptide 1 / Q000172:deficiency / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D007328:Insulin / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D043562:Receptors, G-Protein-Coupled / Q000819:agonists / Q000172:deficiency / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D001647:Bile Acids and Salts; C513561:Gpbar1 protein, mouse; D007328:Insulin; D043562:Receptors, G-Protein-Coupled; D052216:Glucagon-Like Peptide 1; D005947:Glucose