Magnetic poly(PEGMA-MAA) nanoparticles: photochemical preparation and potential application in drug delivery.
Poly(PEGMA-MAA)-coated superparamagnetic nanoparticles were synthesized by in situ photochemical polymerization in magnetite aqueous suspension under UV irradiation. The magnetic poly(PEGMA-MAA) nanoparticles were characterized by Fourier transform infrared spectroscopy (FT-IR), transmission electron microscopy (TEM), photo correlation spectroscopy (PCS) and vibration sample magnetometry (VSM), respectively. The results indicated that the magnetic poly(PEGMA-MAA) nanoparticles were of regularly spherical shape and remained monodisperse. The average size measured in aqueous media was 96.4 nm, which was much bigger than that in dry state, the nanoparticles behaved superparamagnetic with saturated magnetization of 64.8 emu/g, the zeta potential was -18.3 mV at physiological pH 7.2, and the magnetic poly(PEGMA-MAA) nanoparticles had a high stability in vitro. A typical anti-inflammatory drug, ibuprofen, was used for drug loading, and the release behavior of ibuprofen in a simulated body fluid (SBF, pH 7.4) was studied. The results indicated that these novel magnetic nanoparticles had a high drug-loading capacity and favorable release properties for ibuprofen. The magnetic poly(PEGMA-MAA) nanoparticles are very promising for application in drug delivery.
Sun
Han-Wen
HW
Dezhou Institute of Advanced Materials, Dezhou University, Dezhou 253023, People's Republic of China. hanwen916@163.com
Zhang
Lian-Ying
LY
Zhu
Xin-Jun
XJ
Wang
Xin-Fang
XF
D032701:Biomimetics; D001826:Body Fluids / Q000378:metabolism; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D007052:Ibuprofen / Q000737:chemistry / Q000378:metabolism; D008280:Magnetics; D008689:Methacrylates / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D055668:Photochemical Processes; D011092:Polyethylene Glycols / Q000737:chemistry*; D011109:Polymethacrylic Acids / Q000737:chemistry*; D013057:Spectrum Analysis; D013818:Thermogravimetry
D004337:Drug Carriers; D008689:Methacrylates; D011109:Polymethacrylic Acids; C524499:polyethylene glycol methacrylate; C030613:polymethacrylic acid; D011092:Polyethylene Glycols; D007052:Ibuprofen