title: Abnormal parieto-motor connectivity in Tuberous Sclerosis Complex.
abstract: Abnormal connectivity might be involved in the pathophysiology of Tuberous Sclerosis Complex (TSC). We used twin-coil Transcranial Magnetic Stimulation protocol to investigate connectivity between posterior parietal cortex (PPC) and motor cortex (M1) in TSC patients. In comparison with healthy subjects and TSC patients treated with antiepileptic drugs, non-medicated TSC patients exhibited abnormal excitability of PPC-M1 connection. Such altered connectivity might play a role in TSC epileptic phenotype.
authors.affiliation: Paediatric Neurology and Psychiatry Unit, Neuroscience Department, Tor Vergata University, Rome, Italy. luigi.d.argenzio@uniroma2.it
authors.forename: Luigi
authors.initials: L
authors.lastname: D'Argenzio
authors.forename: Giacomo
authors.initials: G
authors.lastname: Koch
authors.forename: Roberta
authors.initials: R
authors.lastname: Bombardieri
authors.forename: Francesco
authors.initials: F
authors.lastname: Mori
authors.forename: Romina
authors.initials: R
authors.lastname: Moavero
authors.forename: Diego
authors.initials: D
authors.lastname: Centonze
authors.forename: Paolo
authors.initials: P
authors.lastname: Curatolo
mesh_terms: D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D001931:Brain Mapping; D004558:Electric Stimulation; D004576:Electromyography; D019054:Evoked Potentials, Motor / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000503:physiopathology*; D009434:Neural Pathways / Q000503:physiopathology; D010296:Parietal Lobe / Q000503:physiopathology*; D012815:Signal Processing, Computer-Assisted; D050781:Transcranial Magnetic Stimulation; D014402:Tuberous Sclerosis / Q000503:physiopathology*