Fully automated synthesis and initial PET evaluation of [11C]PBR28.
Fully automated synthesis and initial PET evaluation of a TSPO radioligand, [11C]PBR28 (N-(2-[11C]methoxybenzyl)-N-(4-phenoxypyridin-3-yl)acetamide), are reported. These results facilitate the potential preclinical and clinical PET studies of [11C]PBR28 in animals and humans.
Wang
Min
M
Department of Radiology, Indiana University School of Medicine, 950 West Walnut Street, Room 427, Indianapolis, IN 46202, USA.
Yoder
Karmen K
KK
Gao
Mingzhang
M
Mock
Bruce H
BH
Xu
Xiao-Ming
XM
Saykin
Andrew J
AJ
Hutchins
Gary D
GD
Zheng
Qi-Huang
QH
D000818:Animals; D002250:Carbon Radioisotopes; D002352:Carrier Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D005260:Female; D058787:GABA-A Receptor Antagonists; D008024:Ligands; D049268:Positron-Emission Tomography; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D011963:Receptors, GABA-A / Q000378:metabolism
C526315:(methyl-(11)C)N-acetyl-N-(2-methoxybenzyl)-2-phenoxy-5-pyridinamine; D002250:Carbon Radioisotopes; D002352:Carrier Proteins; D058787:GABA-A Receptor Antagonists; D008024:Ligands; D011743:Pyrimidines; D019275:Radiopharmaceuticals; D011963:Receptors, GABA-A; C069997:Tspo protein, rat