title: [Use of guinea pigs to evaluate the efficacy of a heterological immunoglobulin against Bolivian hemorrhagic fever].
abstract: The use of guinea pigs as a laboratory model was proven to be appropriate in investigating the protective properties of a heterological immunoglobulin against Bolivian hemorrhagic fever at the preclinical stage of the study. A highly pathogenic Machupo virus strain that caused guinea pigs' death with respect with an agent's dose was cultivated. Injection of 1.0 ml of the immunoglobulin provided a 100% protective effect for the guinea pigs infected with the highly pathogenic Machupo virus strain in a dose of 10 LD50.
authors.forename: A L
authors.initials: AL
authors.lastname: Khmelev
authors.forename: I V
authors.initials: IV
authors.lastname: Borisevich
authors.forename: V B
authors.initials: VB
authors.lastname: Pantiukhov
authors.forename: A P
authors.initials: AP
authors.lastname: Pirozhkov
authors.forename: S I
authors.initials: SI
authors.lastname: Syromiatnikova
authors.forename: I V
authors.initials: IV
authors.lastname: Shatokhina
authors.forename: S A
authors.initials: SA
authors.lastname: Mel'nikov
authors.forename: E E
authors.initials: EE
authors.lastname: Shagarov
mesh_terms: D000818:Animals; D001117:Arenaviridae Infections / Q000628:therapy*; D006477:Arenaviruses, New World; D004195:Disease Models, Animal; D004306:Dose-Response Relationship, Immunologic; D004353:Drug Evaluation, Preclinical; D006168:Guinea Pigs; D007136:Immunoglobulins / Q000008:administration & dosage* / Q000276:immunology*; D007273:Injections, Intramuscular
chemical_list: D007136:Immunoglobulins