title: Macroscopic Borrmann type as a simple prognostic indicator in patients with advanced gastric cancer.
abstract: BACKGROUND
  The purpose of this study was to clarify the clinical significance of macroscopic Borrmann type in advanced gastric cancer.
  
  
  METHODS
  From 1987 to 2001, we retrospectively studied the clinicopathological features and prognoses of 3,966 patients with advanced gastric cancer according to the macroscopic classification of Borrmann type.
  
  
  RESULTS
  Multivariate analysis showed that gender, Borrmann type and depth of invasion were all associated with the status of nodal involvement. There were statistically significant differences in overall survival among patients with Borrmann type I and II tumors, Borrmann type III tumors, and Borrmann type IV tumors according to depth of invasion (pT) and nodal involvement (pN), except in pN3 tumors. Borrmann type was an independent prognostic factor in patients with advanced gastric cancer. Furthermore, the 5-year survival rates of patients with Borrmann type III and type IV tumors after curative resection were 62.0 and 51.2%, respectively; this was significantly higher than after noncurative resection (17.8 and 18.0%, respectively).
  
  
  CONCLUSIONS
  Macroscopic Borrmann type is a simple and valuable predictor for lymph node metastasis and survival in advanced gastric cancer patients.
authors.affiliation: Department of Surgery, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Chen
authors.initials: C
authors.lastname: Li
authors.forename: Sung Jin
authors.initials: SJ
authors.lastname: Oh
authors.forename: Sungsoo
authors.initials: S
authors.lastname: Kim
authors.forename: Woo Jin
authors.initials: WJ
authors.lastname: Hyung
authors.forename: Min
authors.initials: M
authors.lastname: Yan
authors.forename: Zheng Gang
authors.initials: ZG
authors.lastname: Zhu
authors.forename: Sung Hoon
authors.initials: SH
authors.lastname: Noh
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D013274:Stomach Neoplasms / Q000401:mortality / Q000473:pathology*; D015996:Survival Rate