title: Subcortical intracerebral hemorrhage caused by mucormycosis in a patient with a history of bone-marrow transplantation.
abstract: We report on a rare case of a patient with rhinocerebral mucormycosis that presented as intracerebral hemorrhage (ICH). A 54-year-old man who was immunosuppressed had ophthalmoplegia. Four days later, ICH developed in his left frontal lobe. The ICH was surgically removed totally. Pathology specimen surgically obtained from brain surface adjacent to hematoma cavity showed blood vessels filled with Mucor mycelium. Combined with surgical findings, venous occlusion by Mucor mycelium might be the cause of ICH in the patient.
authors.affiliation: Department of Neurosurgery, Keio University School of Medicine, Tokyo, Japan. satoshi710@mac.com
authors.forename: Satoshi
authors.initials: S
authors.lastname: Takahashi
authors.forename: Takashi
authors.initials: T
authors.lastname: Horiguchi
authors.forename: Shuji
authors.initials: S
authors.lastname: Mikami
authors.forename: Youhei
authors.initials: Y
authors.lastname: Kitamura
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kawase
mesh_terms: D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D016026:Bone Marrow Transplantation; D020226:Cavernous Sinus Thrombosis / Q000150:complications / Q000382:microbiology; D002536:Cerebral Arteries / Q000382:microbiology* / Q000473:pathology* / Q000601:surgery; D002543:Cerebral Hemorrhage / Q000382:microbiology* / Q000473:pathology* / Q000601:surgery; D003399:Craniotomy; D017809:Fatal Outcome; D005625:Frontal Lobe / Q000098:blood supply / Q000473:pathology; D006801:Humans; D016867:Immunocompromised Host / Q000502:physiology; D007166:Immunosuppressive Agents / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D009091:Mucormycosis / Q000150:complications* / Q000473:pathology*; D019635:Neurosurgical Procedures; D009886:Ophthalmoplegia / Q000209:etiology; D014057:Tomography, X-Ray Computed; D017211:Treatment Failure; D016896:Treatment Outcome; D014656:Vascular Surgical Procedures; D020246:Venous Thrombosis / Q000150:complications / Q000382:microbiology
chemical_list: D000935:Antifungal Agents; D007166:Immunosuppressive Agents; D000666:Amphotericin B