title: Positron emission tomography in the diagnosis and management of intracranial germ cell tumours.
abstract: Positron emission tomography (PET) with (18)F-fluorodeoxy-glucose indicates metabolically active tissue. When investigating enhancing intracranial tumours, we have suggested that PET positivity might suggest an intracranial germ cell tumour (IGCT). Here, we present a case with dicentric IGCT where PET was initially discordant between the lesions and where PET then became negative despite clearly aggressive clinical behaviour. A cautionary note is introduced with respect to the interpretation of negative (18)F-FDG PET when investigating enhancing intracranial lesions.
authors.affiliation: Department of Endocrinology, St Bartholomew's Hospital, London E1 5AG, UK. p.a.kelly@qmul.ac.uk
authors.forename: Philip A
authors.initials: PA
authors.lastname: Kelly
authors.forename: Karl
authors.initials: K
authors.lastname: Metcalfe
authors.forename: Jane
authors.initials: J
authors.lastname: Evanson
authors.forename: Ian
authors.initials: I
authors.lastname: Sabin
authors.forename: P Nicholas
authors.initials: PN
authors.lastname: Plowman
authors.forename: John P
authors.initials: JP
authors.lastname: Monson
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols; D001932:Brain Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000628:therapy; D017809:Fatal Outcome; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging; D009373:Neoplasms, Germ Cell and Embryonal / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000628:therapy; D010871:Pinealoma / Q000175:diagnosis; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D016879:Salvage Therapy; D012983:Soft Tissue Neoplasms / Q000000981:diagnostic imaging
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18