Fyn kinase function in lipid utilization: a new upstream regulator of AMPK activity?
The balance of cellular energy levels in response to changes of nutrient availability, stress stimuli or exercise is a critical step in maintaining tissue and whole body homeostasis. Disruption of this balance is associated with various pathologies, including the metabolic syndrome. Recently, accumulating evidence has demonstrated that the AMP-activated protein kinase (AMPK) plays a central role in sensing changes in energy levels. The regulation of AMPK activity is currently the subject of significant investigation since this enzyme is a potential therapeutic target in both metabolic disorders and tumorigenesis. In this review, we present novel evidence of crosstalk between Fyn, one member of the Src kinase family, and AMPK.
Vatish
Manu
M
Albert Einstein College of Medicine, Diabetes Research and Training Center, Department of Medicine, Bronx, NY 10461, USA.
Yamada
Eijiro
E
Pessin
Jeffrey E
JE
Bastie
Claire C
CC
D000263:Adenylate Kinase / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000378:metabolism; D050356:Lipid Metabolism; D010084:Oxidation-Reduction; D011487:Protein Conformation; D051076:Proto-Oncogene Proteins c-fyn / Q000378:metabolism*; D015398:Signal Transduction
D007328:Insulin; C494957:FYN protein, human; D051076:Proto-Oncogene Proteins c-fyn; D000263:Adenylate Kinase