High-speed microwave-assisted synthesis of the trifluoromethylpyrazol-derived canonical transient receptor potential (TRPC) channel inhibitor Pyr3.
Glasnov
Toma N
TN
Institute of Chemistry, Karl-Franzens-University Graz, Austria.
Groschner
Klaus
K
Kappe
C Oliver
CO
D000178:Acrylamides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008872:Microwaves; D050778:NFATC Transcription Factors / Q000378:metabolism; D011720:Pyrazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D050052:TRPC Cation Channels / Q000037:antagonists & inhibitors* / Q000378:metabolism
D000178:Acrylamides; D050778:NFATC Transcription Factors; D011720:Pyrazoles; D050052:TRPC Cation Channels; C546697:ethyl 1-(4-(2,3,3-trichloroacrylamido)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate