Pathogen recognition by DC-SIGN shapes adaptive immunity.
Dendritic cells (DCs) tailor adaptive immune responses to specific pathogens. This diversity is mediated by cooperation between different pattern recognition receptors that are triggered by specific pathogens. DC-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN) is a pattern recognition receptor with a broad pathogen recognition specificity as a result of its affinity for mannose and fucose carbohydrates. DC-SIGN induces very diverse immune responses to different pathogens, such as bacteria, fungi, helminths and viruses. Recent data show that DC-SIGN triggering by pathogens modulates Toll-like receptor signaling at the level of nuclear factor-kappaB. In this article, we will discuss the signaling pathways induced by DC-SIGN and its central role in the regulation of adaptive immunity to bacterial, fungal and viral pathogens.
Geijtenbeek
Teunis B H
TB
Department of Molecular Cell Biology & Immunology, VU University Medical Center, 1007 MC Amsterdam, The Netherlands. t.b.geijtenbeek@amc.uva.nl
den Dunnen
Jeroen
J
Gringhuis
Sonja I
SI
D000818:Animals; D001419:Bacteria / Q000276:immunology; D015815:Cell Adhesion Molecules / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology*; D005658:Fungi / Q000276:immunology; D006376:Helminths / Q000276:immunology; D006801:Humans; D037181:Lectins, C-Type / Q000276:immunology*; D008954:Models, Biological; D011956:Receptors, Cell Surface / Q000276:immunology*; D015398:Signal Transduction; D014780:Viruses / Q000276:immunology; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin
D015815:Cell Adhesion Molecules; D037181:Lectins, C-Type; D011956:Receptors, Cell Surface; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin