title: Control of vector populations using genetically modified mosquitoes.
abstract: The ineffectiveness of current strategies for chemical control of mosquito vectors raises the need for developing novel approaches. Thus, we carried out a literature review of strategies for genetic control of mosquito populations based on the sterile insect technique. One of these strategies consists of releasing radiation-sterilized males into the population; another, of integrating a dominant lethal gene under the control of a specific promoter into immature females. Advantages of these approaches over other biological and chemical control strategies include: highly species-specific, environmentally safety, low production cost, and high efficacy. The use of this genetic modification technique will constitute an important tool for integrated vector management.
authors.affiliation: Programa de Pós-Graduação em Saúde Pública, Faculdade de Saúde Pública, Universidade de São Paulo, São Paulo, SP, Brasil.
authors.forename: André Barreto Bruno
authors.initials: AB
authors.lastname: Wilke
authors.forename: Almério de Castro
authors.initials: Ade C
authors.lastname: Gomes
authors.forename: Delsio
authors.initials: D
authors.lastname: Natal
authors.forename: Mauro Toledo
authors.initials: MT
authors.lastname: Marrelli
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D009033:Culicidae / Q000235:genetics*; D005260:Female; D007303:Insect Vectors / Q000235:genetics*; D008297:Male; D009032:Mosquito Control / Q000379:methods*; D012680:Sensitivity and Specificity