title: Plasma levels of trace elements have an implication on interferon treatment of children with chronic hepatitis B infection.
abstract: This study evaluated the plasma levels of trace elements in children with chronic hepatitis B virus (HBV) infection and assessed whether they can be a factor that affects the response to interferon alpha (IFN-alpha) treatment. The study included 35 cases (ten girls, 25 boys) aged 3-13 years with chronic HBV infection and the control group. Plasma levels of copper (Cu), manganese (Mn), molybdenum (Mo), selenium (Se), and zinc (Zn) were measured before IFN-alpha treatment and biochemical, virological, and histopathologic response to treatment were assessed. Children were followed for at least 15 months. Although plasma Cu levels showed no difference between the groups, Mn, Mo, Se, and Zn levels were significantly lower in the study group before treatment. Fourteen cases (40%) showed biochemical response; 17 (48.6%) showed virological response; 16 (47.6%) showed histopathologic response, and ten (28.6%) showed response according to all three parameters. Plasma Cu and Mn levels of patients with triple response showed no difference; but Mo, Se, and Zn levels were significantly lower (p < 0.001) in the study group. No difference was observed between responders and nonresponders (p > 0.05). Plasma levels of Mn, Mo, Se, and Zn are lower in children with chronic HBV infection compared to healthy children. The pretreatment levels of these elements did not show difference between responders and nonresponders to IFN-alpha.
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Gulhane Military Medical Academy, 06010 Ankara, Turkey. balamtekin@hacettepe.edu.tr
authors.forename: Necati
authors.initials: N
authors.lastname: Balamtekin
authors.forename: Ahmet Emin
authors.initials: AE
authors.lastname: Kurekci
authors.forename: Avni
authors.initials: A
authors.lastname: Atay
authors.forename: Süleyman
authors.initials: S
authors.lastname: Kalman
authors.forename: Vedat
authors.initials: V
authors.lastname: Okutan
authors.forename: Erdal
authors.initials: E
authors.lastname: Gokcay
authors.forename: Ahmet
authors.initials: A
authors.lastname: Aydin
authors.forename: Kenan
authors.initials: K
authors.lastname: Sener
authors.forename: Mukerrem
authors.initials: M
authors.lastname: Safali
authors.forename: Okan
authors.initials: O
authors.lastname: Ozcan
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003300:Copper / Q000097:blood; D005260:Female; D006514:Hepatitis B Surface Antigens / Q000097:blood; D019694:Hepatitis B, Chronic / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use*; D008297:Male; D008345:Manganese / Q000097:blood; D008982:Molybdenum / Q000097:blood; D012643:Selenium / Q000097:blood; D014131:Trace Elements / Q000097:blood*; D015032:Zinc / Q000097:blood
chemical_list: D006514:Hepatitis B Surface Antigens; D016898:Interferon-alpha; D014131:Trace Elements; D008345:Manganese; D003300:Copper; D008982:Molybdenum; D012643:Selenium; D015032:Zinc