The relationship between inflammation and regeneration in the MRL mouse: potential relevance for putative human regenerative(scarless wound healing) capacities?
The matrix metalloproteinases (MMPs) have been implicated in the regenerative response in amphibians and various mammalian models of regeneration. The neutrophil response is known to bring MMPs and other proteases to the wound to promote bacterial elimination and tissue remodeling. These issues in relation to what is occurring in the MRL mouse model of regeneration/wound healing are discussed, followed by speculation as to their possible relevance for examples of the putative scarless wound healing described by some medical anthropologists and clinicians.
Heber-Katz
Ellen
E
The Wistar Institute, Philadelphia, Pennsylvania, USA. heberkatz@wistar.org
Gourevitch
Dmitri
D
D000818:Animals; D006801:Humans; D007249:Inflammation / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D020782:Matrix Metalloproteinases / Q000378:metabolism; D051379:Mice; D019463:Mice, Inbred MRL lpr; D009504:Neutrophils / Q000166:cytology / Q000378:metabolism; D012038:Regeneration / Q000502:physiology*; D019714:Tissue Inhibitor of Metalloproteinases / Q000378:metabolism; D014945:Wound Healing / Q000502:physiology*
D019714:Tissue Inhibitor of Metalloproteinases; D020782:Matrix Metalloproteinases