title: Mechanistic insights into water activation in SAM hydroxide adenosyltransferase (duf-62).
authors.affiliation: Centre for Biomolecular Sciences, School of Chemistry, University of St. Andrews, St. Andrews, KY16 9ST, UK.
authors.forename: Hai
authors.initials: H
authors.lastname: Deng
authors.forename: Stephen A
authors.initials: SA
authors.lastname: McMahon
authors.forename: Alessandra S
authors.initials: AS
authors.lastname: Eustáquio
authors.forename: Bradley S
authors.initials: BS
authors.lastname: Moore
authors.forename: James H
authors.initials: JH
authors.lastname: Naismith
authors.forename: David
authors.initials: D
authors.lastname: O'Hagan
mesh_terms: D020134:Catalytic Domain; D004789:Enzyme Activation / Q000187:drug effects; D008716:Methionine Adenosyltransferase / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D008848:Micromonosporaceae / Q000201:enzymology; D008958:Models, Molecular; D016297:Mutagenesis, Site-Directed; D043902:Pyrococcus horikoshii / Q000201:enzymology; D012436:S-Adenosylmethionine / Q000378:metabolism*; D014867:Water / Q000494:pharmacology*
chemical_list: D014867:Water; D012436:S-Adenosylmethionine; D008716:Methionine Adenosyltransferase