title: pH-responsive mechanised nanoparticles gated by semirotaxanes.
abstract: A [2]pseudorotaxane-based mechanised nanoparticle system, which operates within an aqueous acidic environment, has been prepared and characterised; this integrated system affords both water-soluble stalk and ring components in an effort to improve the biocompatibility of these promising new drug delivery vehicles.
authors.affiliation: Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA.
authors.forename: Niveen M
authors.initials: NM
authors.lastname: Khashab
authors.forename: Matthew E
authors.initials: ME
authors.lastname: Belowich
authors.forename: Ali
authors.initials: A
authors.lastname: Trabolsi
authors.forename: Douglas C
authors.initials: DC
authors.lastname: Friedman
authors.forename: Cory
authors.initials: C
authors.lastname: Valente
authors.forename: Yuen
authors.initials: Y
authors.lastname: Lau
authors.forename: Hussam A
authors.initials: HA
authors.lastname: Khatib
authors.forename: Jeffrey I
authors.initials: JI
authors.lastname: Zink
authors.forename: J Fraser
authors.initials: JF
authors.lastname: Stoddart
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry; D001952:Bridged-Ring Compounds / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods*; D006863:Hydrogen-Ion Concentration; D007093:Imidazoles / Q000737:chemistry; D047028:Macrocyclic Compounds / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D053758:Nanoparticles / Q000737:chemistry*; D012235:Rhodamines / Q000737:chemistry; D043862:Rotaxanes / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry; D013050:Spectrometry, Fluorescence; D014755:Viologens / Q000737:chemistry; D000099246:Cucurbit(n)urils
chemical_list: D001672:Biocompatible Materials; D001952:Bridged-Ring Compounds; D007093:Imidazoles; D047028:Macrocyclic Compounds; D012235:Rhodamines; D043862:Rotaxanes; D012822:Silicon Dioxide; D014755:Viologens; C454805:cucurbit(6)uril; D000099246:Cucurbit(n)urils; C029773:rhodamine B