title: The 90-day mortality and the subsequent renal recovery in critically ill surgical patients requiring acute renal replacement therapy.
abstract: BACKGROUND
  Particular attention should be paid to postoperative patients that suffer from severe acute kidney injury (AKI) requiring renal replacement therapy (RRT).
  
  
  METHODS
  This multicenter prospective observational study included 342 patients with postoperative AKI requiring RRT from January 2002 to December 2006.
  
  
  RESULTS
  There were 137 (40%) survivors at 90 days after the commencement of RRT. Independent predictors of 90-day mortality were older age, presence of sepsis, status post-cardiopulmonary resuscitation, necessity of continuous renal replacement therapy (CRRT), requirement of total parenteral nutrition, lower body mass index, higher Sequential Organ Failure Assessment score, and higher serum lactate level at the commencement of RRT. Further analysis among the survivors showed that lower serum creatinine at intensive care unit admission, lower Simplified Acute Physiology Score II and inotropic equivalent score at the commencement of RRT, and using CRRT were independent predictors for subsequent renal recovery.
  
  
  CONCLUSIONS
  The development of AKI requiring RRT in postoperative critical patients represents a substantial risk for mortality and morbidity.
authors.affiliation: Department of Nephrology, National Taiwan University Hospital Yun-Lin Branch, Yun-Lin, Taiwan.
authors.forename: Yu-Feng
authors.initials: YF
authors.lastname: Lin
authors.forename: Wen-Je
authors.initials: WJ
authors.lastname: Ko
authors.forename: Tzong-Shinn
authors.initials: TS
authors.lastname: Chu
authors.forename: Yih-Sharng
authors.initials: YS
authors.lastname: Chen
authors.forename: Vin-Cent
authors.initials: VC
authors.lastname: Wu
authors.forename: Yung-Ming
authors.initials: YM
authors.lastname: Chen
authors.forename: Ming-Shiou
authors.initials: MS
authors.lastname: Wu
authors.forename: Yung-Wei
authors.initials: YW
authors.lastname: Chen
authors.forename: Ching-Wei
authors.initials: CW
authors.lastname: Tsai
authors.forename: Chih-Chung
authors.initials: CC
authors.lastname: Shiao
authors.forename: Wen-Yi
authors.initials: WY
authors.lastname: Li
authors.forename: Fu-Chang
authors.initials: FC
authors.lastname: Hu
authors.forename: Pi-Ru
authors.initials: PR
authors.lastname: Tsai
authors.forename: Tun-Jun
authors.initials: TJ
authors.lastname: Tsai
authors.forename: Kwan-Dun
authors.initials: KD
authors.lastname: Wu
mesh_terms: D018806:APACHE; D058186:Acute Kidney Injury / Q000401:mortality* / Q000628:therapy*; D000368:Aged; D015992:Body Mass Index; D003404:Creatinine / Q000097:blood; D016638:Critical Illness / Q000401:mortality*; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure; D010289:Parenteral Nutrition, Total; D011183:Postoperative Complications / Q000401:mortality* / Q000628:therapy*; D011237:Predictive Value of Tests; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012372:ROC Curve; D017582:Renal Replacement Therapy / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D003404:Creatinine