Efficient regioselective synthesis of indole N-carboximidamides and N-carboximidoates by a sequential Aza-Wittig/Ag(I)-catalyzed cyclization.
An efficient Ag(I)-catalyzed regioselective cyclization of (2-alkynylphenyl)guanidine or (2-alkynylphenyl)isourea to indole N-carboximidamides or N-carboximidoates has been developed. The approach has the advantages of high regioselectivity, mild reaction conditions, easily accessible starting materials, and good yields.
Huang
Nian-Yu
NY
Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, Central China Normal University, Wuhan 430079, People's Republic of China.
Liu
Ming-Guo
MG
Ding
Ming-Wu
MW
D000577:Amides / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D002625:Chemistry, Organic / Q000379:methods; D002626:Chemistry, Pharmaceutical / Q000379:methods; D018360:Crystallography, X-Ray; D003500:Cyclization; D015195:Drug Design; D007094:Imides / Q000138:chemical synthesis* / Q000737:chemistry; D007211:Indoles / Q000138:chemical synthesis*; D008956:Models, Chemical; D015394:Molecular Structure; D012834:Silver / Q000737:chemistry; D013696:Temperature; D014508:Urea / Q000737:chemistry
D000577:Amides; D007094:Imides; D007211:Indoles; D012834:Silver; D002244:Carbon; D014508:Urea