[Fat soluble vitamins for maintaining bone health].
Vitamin D and K are nutrients necessary for bone health. Vitamin D insufficiency, which is milder than vitamin D deficiency to cause rickets and osteomalacia, is associated with increased fracture risk. Serum 25 (OH) D concentration, a good marker for vitamin D status, must be higher than the traditional held consensus of 20 ng/mL for bone health. Daily dose of 800 IU or higher is considered to be necessary for fracture prevention. Recently, much attention has been paid on extra-hepatic actions of vitamin K including bone. Elevated serum concentration of undercarboxylated osteocalcin, a sensitive marker for vitamin K inadequacy in the bone, is a risk factor for fracture independent of bone mineral density.
Tanaka
Kiyoshi
K
Department of Food and Nutrition, Kyoto Women's University.
Kuwabara
Akiko
A
D015415:Biomarkers / Q000097:blood; D005223:Fats; D050723:Fractures, Bone / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D015675:Osteocalcin / Q000097:blood; D010018:Osteomalacia / Q000209:etiology; D012279:Rickets / Q000209:etiology; D012306:Risk; D012995:Solubility; D014807:Vitamin D / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000097:blood; D014808:Vitamin D Deficiency / Q000150:complications / Q000175:diagnosis; D014812:Vitamin K / Q000008:administration & dosage; D014813:Vitamin K Deficiency / Q000175:diagnosis
D015415:Biomarkers; D005223:Fats; D015675:Osteocalcin; D014812:Vitamin K; D014807:Vitamin D; C104450:25-hydroxyvitamin D