title: The importance of target validation in drug discovery and development.
authors.forename: John A
authors.initials: JA
authors.lastname: Lowe
authors.forename: Phil
authors.initials: P
authors.lastname: Jones
authors.forename: David M
authors.initials: DM
authors.lastname: Wilson
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000494:pharmacology*; D019440:Anti-Obesity Agents / Q000009:adverse effects / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000494:pharmacology*; D002491:Central Nervous System Agents / Q000009:adverse effects / Q000494:pharmacology*; D004195:Disease Models, Animal; D015195:Drug Design; D055808:Drug Discovery; D004353:Drug Evaluation, Preclinical; D006801:Humans; D034622:RNA Interference; D013045:Species Specificity; D017211:Treatment Failure; D054928:Validation Studies as Topic
chemical_list: D000900:Anti-Bacterial Agents; D019440:Anti-Obesity Agents; D000970:Antineoplastic Agents; D002491:Central Nervous System Agents