The use of mitochondrial nutrients to improve the outcome of infertility treatment in older patients.
We present a hypothesis emphasizing the role of mitochondrial dysfunction in reproductive senescence and suggesting the use of mitochondrial nutrients as an adjuvant treatment in older patients with infertility.
Bentov
Yaakov
Y
Toronto Centre for Advanced Reproductive Technology, University of Toronto, Toronto, Ontario, Canada.
Esfandiari
Navid
N
Burstein
Eliezer
E
Casper
Robert F
RF
D000367:Age Factors; D000375:Aging / Q000378:metabolism; D000818:Animals; D004272:DNA, Mitochondrial / Q000378:metabolism; D019587:Dietary Supplements; D004734:Energy Metabolism / Q000187:drug effects; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D051379:Mice; D008813:Mice, Inbred ICR; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism; D009865:Oocytes / Q000187:drug effects* / Q000378:metabolism; D011247:Pregnancy; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology; D008063:Thioctic Acid / Q000494:pharmacology; D014451:Ubiquinone / Q000494:pharmacology*
D004272:DNA, Mitochondrial; D013267:Stilbenes; D014451:Ubiquinone; D008063:Thioctic Acid; D000077185:Resveratrol