title: Extracellular redox modulation by regulatory T cells.
abstract: We demonstrate that the mechanism of redox remodeling during mouse T-cell activation involves secretion of glutathione by dendritic cells and its subsequent cleavage to cysteine. Extracellular cysteine accumulation results in a lower redox potential, which is conducive to proliferation, and changes the net redox status of exofacial protein domains. Regulatory T cells inhibit this redox metabolite signaling pathway, which represents a previously unrecognized mechanism for immunosuppression of effector T cells.
authors.affiliation: Department of Biological Chemistry, University of Michigan Medical Center, Ann Arbor, Michigan, USA.
authors.forename: Zhonghua
authors.initials: Z
authors.lastname: Yan
authors.forename: Sanjay K
authors.initials: SK
authors.lastname: Garg
authors.forename: Jonathan
authors.initials: J
authors.lastname: Kipnis
authors.forename: Ruma
authors.initials: R
authors.lastname: Banerjee
mesh_terms: D000818:Animals; D015153:Blotting, Western; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D018920:Coculture Techniques; D003545:Cysteine / Q000378:metabolism* / Q000494:pharmacology; D003713:Dendritic Cells / Q000276:immunology / Q000378:metabolism*; D005110:Extracellular Space / Q000378:metabolism*; D005434:Flow Cytometry; D005978:Glutathione / Q000378:metabolism*; D008213:Lymphocyte Activation / Q000276:immunology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010084:Oxidation-Reduction; D015398:Signal Transduction / Q000187:drug effects; D050378:T-Lymphocytes, Regulatory / Q000276:immunology* / Q000378:metabolism
chemical_list: D005978:Glutathione; D003545:Cysteine