title: Microbial metabolism. Part 10: Metabolites of 7,8-dimethoxyflavone and 5-methoxyflavone.
abstract: Microbial transformation of 7,8-dimethoxyflavone (1) by Mucor ramannianus produced five metabolites: 7,8-dimethoxy-4'-hydroxyflavone (2), 3',4'-dihydroxy-7,8-dimethoxyflavone (3), 7,3'-dihydroxy-8-methoxyflavone (4), 7,4'-dihydroxy-8-methoxyflavone (5) and 8-methoxy-7,3',4'-trihydroxyflavone (6). It was, however, completely converted to a single metabolite, 7-hydroxy-8-methoxyflavone (7) by Aspergillus flavus. 5-Methoxyflavone (8), when fermented with Beauveria bassiana, gave a single product, 5-methoxyflavanone (9). Conversion of 8 with Aspergillus alliaceus yielded the metabolite 4'-hydroxy-5-methoxyflavone (10). The structures of the compounds 2-7, 9 and 10 were established by spectroscopic methods.
authors.affiliation: National Center for Natural Products Research, University of Mississippi, University, MS 38677, USA.
authors.forename: Wimal
authors.initials: W
authors.lastname: Herath
authors.forename: Julie
authors.initials: J
authors.lastname: Rakel Mikell
authors.forename: Ikhlas
authors.initials: I
authors.lastname: Ahmad Khan
mesh_terms: D001230:Aspergillus / Q000378:metabolism*; D001231:Aspergillus flavus / Q000378:metabolism; D052982:Beauveria / Q000378:metabolism*; D047309:Flavones; D005419:Flavonoids / Q000737:chemistry* / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009089:Mucor / Q000378:metabolism*
chemical_list: D047309:Flavones; D005419:Flavonoids; C043562:flavone