Angiotensin II type 1 receptor gene polymorphism in myocardial infarction patients.
BACKGROUND
Acute myocardial infarction is commonly known as heart attack. It is a multifactorial disease influenced by environmental and genetic factors.The objective of the present study was to investigate the association of the angiotensin II type 1 receptor gene A/C polymorphism in South Indian myocardial infarction patients.Subjects and methods. The present study included a total number of 221 subjects (107 myocardial infarction patients and 114 age- and sex-matched controls). Demographic and clinical characteristics were collected. Lipid profiles were estimated. DNA was isolated and the angiotensin II type 1 receptor gene A/C polymorphism was determined by polymerase chain reaction.


RESULTS
Comparison of the lipid profiles between patients and controls showed that patients had statistically highly significant values (p=0.0001).The CC genotype of the angiotensin II type 1 receptor was not associated with myocardial infarction patients when compared to controls. CC vs. AA was chi(2) = 2.08, odds ratio 2.30, 95% confidence interval 0.72 - 7.23, and p value was 0.14.


CONCLUSIONS
The angiotensin II type 1 receptor CC genotype is not a risk factor for myocardial infarction in patients in a South Indian population.
Bhoomi Reddy Pullareddy
Institute of Genetics and Hospital for Genetic Diseases, Begumpet, Hyderabad 500016, India.
Baddela Muni Venkata Srikanth Babu
Kolla Venkata Karunakar
Yasovanthi
Jeedigunta
J
Potham Sampath Kumar
Sharath
Annam
A
Jyothy
Akka
A
D000328:Adult; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D003710:Demography; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007194:India; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D044140:Receptor, Angiotensin, Type 1 / Q000235:genetics*
D008055:Lipids; D044140:Receptor, Angiotensin, Type 1