title: Rest-activity and behavioral disruption in a patient with frontotemporal dementia.
abstract: The neurological deterioration in dementia is associated with disturbances in circadian rhythms and rest-activity patterns. These disruptions have been documented in Alzheimer's disease (AD) and dementia with Lewy bodies but little is known about rest-activity patterns in patients with frontotemporal dementia (FTD). We report longitudinal (2 year) actigraphy results for a patient who met diagnostic criteria for FTD and his family caregiver. The subject and his family caregiver wore Actiwatches continuously for 2 weeks at 1-year intervals. The findings suggest that with disease progression there is worsening in multiple areas of rest-activity measures for the patient and a negative impact on sleep quality for the family caregiver.
authors.affiliation: University of California, San Francisco, Memory and Aging Center, 350 Parnassus Ave., San Francisco, CA 94019-1207, USA. jmerrilees@memory.ucsf.edu
authors.forename: J
authors.initials: J
authors.lastname: Merrilees
authors.forename: E
authors.initials: E
authors.lastname: Hubbard
authors.forename: J
authors.initials: J
authors.lastname: Mastick
authors.forename: B L
authors.initials: BL
authors.lastname: Miller
authors.forename: G A
authors.initials: GA
authors.lastname: Dowling
mesh_terms: D001519:Behavior; D001921:Brain / Q000473:pathology; D017028:Caregivers; D002940:Circadian Rhythm; D018450:Disease Progression; D005260:Female; D057180:Frontotemporal Dementia / Q000473:pathology; D006801:Humans; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009043:Motor Activity; D009483:Neuropsychological Tests; D017440:Photoperiod; D012146:Rest; D012890:Sleep; D013997:Time Factors