An epitome of DNA repair related genes and mechanisms in thyroid carcinoma.
Thyroid cancer presents a growing tendency during the last decades, particularly in regions affected by radiation exposure. The present review describes expression alterations and gene polymorphisms of DNA repair related molecules, leading to genomic instability and cell death, being associated with thyroid cancer. The referred variations in DNA repair related genes depict that indirect repair mechanisms are mainly correlated with thyroid gland carcinogenesis. Such abnormalities could participate in thyroid tumor development and progression and could be targeted for future prevention and therapy.
Gatzidou
Elisavet
E
Department of Forensic Medicine and Toxicology, National and Kapodistrian University of Athens, Greece.
Michailidi
Christina
C
Tseleni-Balafouta
Sophia
S
Theocharis
Stamatios
S
D002277:Carcinoma / Q000235:genetics*; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D004260:DNA Repair / Q000235:genetics*; D006801:Humans; D013964:Thyroid Neoplasms / Q000235:genetics*