title: Relationship between polymorphism in the manganese superoxide dismutase gene and breast cancer.
abstract: Manganese superoxide dismutase (MnSOD) acts as an antioxidant and protects cells from the harmful effects of reactive oxygen species. We investigated the relationship between the MnSOD Ala-9Val polymorphism and breast cancer. Genotypes of 250 cases and 330 controls were determined by use of PCR-RFLP. Compared with the MnSOD Val/Val genotype, the MnSOD Val/Ala or MnSOD Ala/Ala genotype was not significantly associated with the overall risk for breast cancer. The risk increased in women with MnSOD Ala allele-containing genotypes as well as higher level of education (Ala/Ala: OR, 6.00; 95% CI, 1.02-35.33), BMI >or= 25 kg/m(2) (Val/Ala: OR, 1.74; 95% CI, 1.10-2.76), late age at first pregnancy (Val/Ala: OR, 1.52; 95% CI, 1.01-2.42), and premenopausal status (Val/Ala: OR, 1.78; 95% CI, 1.03-3.10). In conclusion, the MnSOD Ala-9Val polymorphism may contribute to an increased risk for breast cancer development, particularly in the presence of a higher level of education, high BMI, late age at first pregnancy, and premenopausal status.
authors.affiliation: Department of Medical Biology and Genetics, Faculty of Medicine, Mersin University, Mersin, Turkey. nazaneras@gmail.com
authors.forename: N
authors.initials: N
authors.lastname: Eras-Erdogan
authors.forename: E
authors.initials: E
authors.lastname: Akbas
authors.forename: H
authors.initials: H
authors.lastname: Senli
authors.forename: S
authors.initials: S
authors.lastname: Kul
authors.forename: T
authors.initials: T
authors.lastname: Colak
mesh_terms: D001943:Breast Neoplasms / Q000201:enzymology* / Q000235:genetics* / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000453:epidemiology*; D006801:Humans; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors; D013482:Superoxide Dismutase / Q000235:genetics* / Q000378:metabolism; D014421:Turkey / Q000453:epidemiology
chemical_list: D013482:Superoxide Dismutase