[Acute-phase proteins in patients with primary stroke and prodromal transient ischemic attacks].
A study aimed at investigating of the relationship between concentrations of several acute-phase proteins and clinical course and functional outcome of ischemic stroke in patients with and without prodromal transient ischemic attacks (TIA). Eighty-five patients with baseline moderate severity of stroke (NIHSS=12+/-3,5) have been stratified into 3 groups: 1st group - with first-ever stroke, 2nd - with prodromal TIA two or three months before stroke and 3rd - with prodromal TIA within 4 weeks before stroke. Brain lesions were evaluated on conventional MRI. Clinical course of disease and stroke outcome at 1 month were assessed by the NIHSS - by the Barthel index, respectively. A control group comprised 22 healthy people. Blood free radicals (NO, LOO-) and iron transporting proteins (oxidized ceruloplasmine, Fe3+ transferine), blood nitrate levels (NO2), activity of superoxiddismutase, activity of glutathione peroxidase have been studied. No significant between-group differences in regard to blood NO and LOO- contents, activities of blood erythrocyte antioxidant enzymes were found. Baseline levels of NO2 (p<0,05) and iron transporting proteins (p<0,01) were significantly higher in the 3rd group of patients and were correlated with better clinical course of stroke and better functional outcome (r=-0,31 and r=-0,37 respectively, p<0,05). It can be supposed that the elevated level of protective proteins in the 3rd group is caused by the development of ischemic tolerance.
Beridze
M Z
MZ
Shakarishvili
R R
RR
Megrelishvili
M K
MK
D000209:Acute-Phase Proteins / Q000378:metabolism*; D000368:Aged; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D002546:Ischemic Attack, Transient / Q000097:blood* / Q000175:diagnosis; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012720:Severity of Illness Index; D013053:Spectrophotometry; D020521:Stroke / Q000097:blood* / Q000175:diagnosis
D000209:Acute-Phase Proteins; D015415:Biomarkers