[Incretin and bone].
Gastrointestinal hormones including gastric inhibitory polypeptide (GIP) and glucagon-like peptide (GLP) -1 are incretin, which are secreted immediately after meal ingestion and stimulate insulin secretion from pancreatic beta-cells. Characterization of extra-pancreatic GIP and GLP-1 receptors has revealed that these hormones regulate bone turnover. GIP intermittently stimulates osteoblasts and GLP-1 suppresses osteoclasts through a calcitonin-dependent pathway to increase the bone volume.
Yamada
Yuichiro
Y
Department of Endocrinology, Diabetes and Geriatric Medicine, Akita University Graduate School of Medicine.
D000818:Animals; D001842:Bone and Bones / Q000378:metabolism*; D002116:Calcitonin / Q000502:physiology; D004435:Eating / Q000502:physiology; D005749:Gastric Inhibitory Polypeptide / Q000378:metabolism / Q000502:physiology; D052216:Glucagon-Like Peptide 1 / Q000378:metabolism / Q000502:physiology; D000067757:Glucagon-Like Peptide-1 Receptor; D006801:Humans; D054795:Incretins / Q000378:metabolism / Q000502:physiology*; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D050417:Insulin-Secreting Cells / Q000378:metabolism; D010006:Osteoblasts / Q000502:physiology; D010010:Osteoclasts / Q000502:physiology; D011964:Receptors, Gastrointestinal Hormone / Q000502:physiology; D018027:Receptors, Glucagon / Q000502:physiology
C000593833:GLP1R protein, human; D000067757:Glucagon-Like Peptide-1 Receptor; D054795:Incretins; D007328:Insulin; D011964:Receptors, Gastrointestinal Hormone; D018027:Receptors, Glucagon; D005749:Gastric Inhibitory Polypeptide; D052216:Glucagon-Like Peptide 1; D002116:Calcitonin; C041086:gastric inhibitory polypeptide receptor