Role of the ghrelin/obestatin balance in the regulation of neuroendocrine circuits controlling body composition and energy homeostasis.
Ghrelin and obestatin are two peptides isolated from the gastrointestinal tract and encoded by the same preproghrelin gene. They convey to the central nervous system informations concerning the nutritional status and/or the energy stores. Ghrelin, mostly acting through the GH secretagogue receptor GHS-R, is a potent GH secretagogue, an orexigenic peptide and a long-term regulator of energy homeostasis. Obestatin was initially described for its anorexigenic effects and its binding to the G protein-coupled receptor 39 (GPR39). However, the role of obestatin is still controversial and the nature of the obestatin receptor remains an open question. This review is focussed on the possible implication of the ghrelin/obestatin system in psychiatric diseases with particular emphasis on eating disorders.
Epelbaum
Jacques
J
Centre de Psychiatrie & Neurosciences, UMR 894 Inserm, Faculté de Médecine, Université Paris Descartes, Paris, France. jacques.epelbaum@inserm.fr
Bedjaoui
Nawel
N
Dardennes
Roland
R
Feng
Dan Dan
DD
Gardette
Robert
R
Grouselle
Dominique
D
Loudes
Catherine
C
Simon
Axelle
A
Tolle
Virginie
V
Yang
Seung Kwon
SK
Zizzari
Philippe
P
D000818:Animals; D001823:Body Composition / Q000502:physiology*; D004734:Energy Metabolism / Q000502:physiology*; D025461:Feedback, Physiological / Q000502:physiology; D054439:Ghrelin / Q000378:metabolism*; D006801:Humans; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism; D054440:Receptors, Ghrelin / Q000378:metabolism
C495797:GPR39 protein, human; D054439:Ghrelin; D043562:Receptors, G-Protein-Coupled; D054440:Receptors, Ghrelin