Highly chemoselective copper-catalyzed conjugate reduction of stereochemically labile alpha,beta-unsaturated amino ketones.
Highly chemoselective conjugate reduction of chiral alpha,beta-unsaturated amino ketones has been developed by using triisopropyl phosphite ligated copper hydride complex. The highlights of the method are wide substrate compatibility and exceptional chemoselectivity.
Pelss
Andrejs
A
Department of Chemistry, Helsinki University of Technology, P.O. Box 6100, FIN-02015 HUT, Espoo, Finland.
Kumpulainen
Esa T T
ET
Koskinen
Ari M P
AM
D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D013237:Stereoisomerism
D007659:Ketones; D009942:Organometallic Compounds; D003300:Copper