title: Corneal thickness association with ocular and corneal high-order aberrations.
abstract: OBJECTIVE
  To investigate the association among central corneal thickness, peripheral corneal thickness (PCT), and wavefront aberrations in the anterior cornea, posterior cornea and the whole eye in myopia.
  
  
  METHODS
  Sixty-four eyes of 64 myopic subjects were evaluated with a Pentacam rotating Scheimpflug camera (Oculus, Inc., WA) corneal topographer for: (1) wavefront aberrations from the anterior and posterior corneal surface, (2) corneal thickness (central and peripheral), and (3) with a wavefront aberration-supported cornea ablation wavefront analyzer (Wavescan, Visx, Inc., Santa Clara, CA) for wavefront aberrations generated in the whole eye. Relationships between the wavefront aberrations and corneal thickness were analyzed.
  
  
  RESULTS
  The mean age of subjects was 34.75 +/- 10.08 years. The central corneal thickness was 550.5 +/- 28.459 microm. The mean peripheral thickness was 629.9 +/- 32.1 microm. Central and PCTs were not significantly correlated with corneal or ocular high-order aberrations. Intraocular pressure was significantly correlated with ocular trefoil (r = -0.307, P=0.001).
  
  
  CONCLUSIONS
  Central and PCT were not significantly associated with either anterior or posterior corneal Zernike aberrations; in addition, no association with the whole ocular wavefront aberrations was found.
authors.affiliation: Ophthalmology Department, University of Texas Southwestern Medical Center at Dallas, 75390-9057, USA.
authors.forename: Engy M
authors.initials: EM
authors.lastname: Mohamed
authors.forename: Jadwiga C
authors.initials: JC
authors.lastname: Wojtowicz
authors.forename: Wayne
authors.initials: W
authors.lastname: Bowman
authors.forename: H Dwight
authors.initials: HD
authors.lastname: Cavanagh
authors.forename: Vinod
authors.initials: V
authors.lastname: Mootha
authors.forename: Steven
authors.initials: S
authors.lastname: Verity
authors.forename: James P
authors.initials: JP
authors.lastname: McCulley
mesh_terms: D000328:Adult; D000367:Age Factors; D003315:Cornea / Q000473:pathology*; D019781:Corneal Topography; D057108:Corneal Wavefront Aberration / Q000150:complications* / Q000473:pathology*; D005123:Eye / Q000473:pathology*; D005260:Female; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D009216:Myopia / Q000473:pathology* / Q000503:physiopathology