Significant association between the C(-1019)G functional polymorphism of the HTR1A gene and impulsivity.
Serotonin-1A (5-HT(1A)) receptors are known to play a role in impulsivity-related behavior. The C(-1019)G functional polymorphism (rs6295) has been suggested to regulate the 5-HT(1A) receptor gene (HTR(1A)) expression in presynaptic raphe neurons, namely, increased receptor concentration and reduced neuronal firing could be associated with the G allele. Previous studies indicate that this polymorphism is associated with aggression, suicide, and several psychiatric disorders, yet its association with impulsivity has rarely been investigated. We studied the relationship between impulsivity and the C(-1019)G polymorphism of the HTR(1A) in a population sample of 725 volunteers using the Impulsiveness subscale (IVE-I) of the Eysenck Impulsiveness, Venturesomeness, and Empathy scale and also the Barratt Impulsiveness Scale (BIS-11). Data were analyzed using analysis of variance with age and gender as covariates and Tukey's HSD post-hoc test. Post-hoc analysis revealed that the study had 0.958 power to detect 0.15 effect size. Significant differences between the C(-1019)G genotype groups (GG vs. GC vs. CC) were found. Subjects carrying GG genotype showed significantly higher impulsiveness scores compared to GC or CC carriers for the IVE-I scale (P = 0.014), for the Motor (P = 0.021), Cognitive Impulsiveness (P = 0.002), and for the BIS total score (P = 0.008) but not for the Nonplanning Impulsiveness (P = 0.520) subscale of the BIS-11. Our results suggest the involvement of the HTR(1A) in the continuum phenotype of impulsivity.
Benko
Anita
A
Department of Pharmacodynamics, Semmelweis University, Budapest, Hungary.|Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary.
Lazary
Judit
J
Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary.
Molnar
Eszter
E
Department of Pharmacodynamics, Semmelweis University, Budapest, Hungary.|Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary.
Gonda
Xenia
X
Department of Pharmacodynamics, Semmelweis University, Budapest, Hungary.|Department of Clinical and Theoretical Mental Health, Semmelweis University, Budapest, Hungary.
Tothfalusi
Laszlo
L
Department of Pharmacodynamics, Semmelweis University, Budapest, Hungary.
Pap
Dorottya
D
Department of Pharmacodynamics, Semmelweis University, Budapest, Hungary.
Mirnics
Zsuzsanna
Z
Faculty of Humanities, Department of Psychology, Karoli Gaspar University of the Reformed Church, Budapest, Hungary.
Kurimay
Tamas
T
Department of Psychiatry, Saint John's Hospital, Budapest, Hungary.
Chase
Diana
D
Faculty of Medical and Human Sciences, Neuroscience and Psychiatry Unit, School of Community Based Medicine, The University of Manchester, Manchester, UK.
Juhasz
Gabriella
G
Faculty of Medical and Human Sciences, Neuroscience and Psychiatry Unit, School of Community Based Medicine, The University of Manchester, Manchester, UK.
Anderson
Ian M
IM
Faculty of Medical and Human Sciences, Neuroscience and Psychiatry Unit, School of Community Based Medicine, The University of Manchester, Manchester, UK.
Deakin
John F W
JFW
Faculty of Medical and Human Sciences, Neuroscience and Psychiatry Unit, School of Community Based Medicine, The University of Manchester, Manchester, UK.
Bagdy
Gyorgy
G
Department of Pharmacodynamics, Semmelweis University, Budapest, Hungary.|Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary.|Group of Neurochemistry and Group of Neuropsychopharmacology, Hungarian Academy of Science and Semmelweis University, Budapest, Hungary.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000483:Alleles; D003071:Cognition; D005260:Female; D005824:Genetics, Behavioral; D005838:Genotype; D006801:Humans; D007175:Impulsive Behavior / Q000235:genetics*; D008297:Male; D009474:Neurons / Q000378:metabolism; D011110:Polymorphism, Genetic; D044282:Receptor, Serotonin, 5-HT1A / Q000235:genetics*; D012737:Sex Factors
D044282:Receptor, Serotonin, 5-HT1A