One-pot synthesis of highly substituted aromatic amine derivatives via Pd-catalyzed aminobenzannulation reaction.
A novel and convenient Pd(0)-catalyzed carboannulation with propargylic compounds for the synthesis of highly substituted aromatic amine derivatives in a one-pot operation was developed. In this process, a significant breakthrough in aminobenzannulation is observed. Moreover, the reaction appears to be very general and suitable for a variety of amines.
Gou
Fa-Rong
FR
State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, People's Republic of China.
Huo
Peng-Fei
PF
Bi
Hai-Peng
HP
Guan
Zheng-Hui
ZH
Liang
Yong-Min
YM