title: [Effect of liquorice decoction on rat intestinal P-glycoprotein].
abstract: OBJECTIVE
  To investigate the effect of liquorice in functional modulation of intestinal P-glycoprotein (P-gp) in rats.
  
  
  METHODS
  An in vitro diffusion chamber system (Ussing chamber) was used to examine the direct effect of liquorice decoction on rhodamine 123 (a subtrate of P-gp) transport and evaluate the permeability of rhodamine 123 or fluorescein sodium through rat jejunum membranes after oral administration of liquorice decoction.
  
  
  RESULTS
  Direct application of liquorice decoction did not obviously affect rhodamine 123 transport across the intestinal mucosa. Oral administration of liquorice decoction (10 g/kg, twice daily for a week) significantly increased the absorption of rhodamine 123 and also enhanced rhodamine 123 secretion across the jejunum mucosa. Liquorice had no obvious effect on the transport of CF across the jejunum mucosa.
  
  
  CONCLUSIONS
  Liquorice may slightly inhibit P-gp function in the intestinal mucosa to increase the intestinal absorption of rhodamine 123.
authors.affiliation: Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
authors.forename: Hong-wei
authors.initials: HW
authors.lastname: Yao
authors.forename: Xiao-you
authors.initials: XY
authors.lastname: Fu
authors.forename: Qing-dong
authors.initials: QD
authors.lastname: Xie
authors.forename: Bei-bei
authors.initials: BB
authors.lastname: Huang
authors.forename: Ya-bin
authors.initials: YB
authors.lastname: Sun
authors.forename: Guo-feng
authors.initials: GF
authors.lastname: Li
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D000818:Animals; D006035:Glycyrrhiza; D007408:Intestinal Absorption / Q000187:drug effects; D007413:Intestinal Mucosa / Q000187:drug effects / Q000378:metabolism*; D007422:Intestines / Q000187:drug effects*; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D020112:Rhodamine 123 / Q000378:metabolism
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D010936:Plant Extracts; C069074:liquorice decocta; D020112:Rhodamine 123