title: Shape and release control of a peptide decorated vesicle through pH sensitive orthogonal supramolecular interactions.
abstract: A pH sensitive carrier is obtained by coating a cyclodextrin vesicle with an adamantane-terminated octapeptide through the formation of an inclusion complex. Upon lowering the pH from 7.4 to 5.0, the formation of peptide beta-sheets on the vesicle surface induces a transition of the bilayer from a sphere to a fiber. This transition is fully reversible and repeatable. The vesicles release their cargo upon fiber formation.
authors.affiliation: Leiden Institute of Chemistry, University Leiden, P.O. Box 9502, 2300 RA, Leiden, The Netherlands.
authors.forename: Frank
authors.initials: F
authors.lastname: Versluis
authors.forename: Itsuro
authors.initials: I
authors.lastname: Tomatsu
authors.forename: Seda
authors.initials: S
authors.lastname: Kehr
authors.forename: Carlo
authors.initials: C
authors.lastname: Fregonese
authors.forename: Armand W J W
authors.initials: AW
authors.lastname: Tepper
authors.forename: Marc C A
authors.initials: MC
authors.lastname: Stuart
authors.forename: Bart Jan
authors.initials: BJ
authors.lastname: Ravoo
authors.forename: Roman I
authors.initials: RI
authors.lastname: Koning
authors.forename: Alexander
authors.initials: A
authors.lastname: Kros
mesh_terms: D002942:Circular Dichroism; D003505:Cyclodextrins / Q000737:chemistry; D005456:Fluorescent Dyes / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D008567:Membranes, Artificial; D009842:Oligopeptides / Q000737:chemistry*; D017433:Protein Structure, Secondary; D013499:Surface Properties
chemical_list: D003505:Cyclodextrins; D005456:Fluorescent Dyes; D008567:Membranes, Artificial; D009842:Oligopeptides