Subcutaneous anti-D treatment of idiopathic thrombocytopenic purpura in children.
We investigated the effect of subcutaneous anti-D IgG as platelet enhancing therapy in children with idiopathic thrombocytopenic purpura (ITP). Twenty-three children were treated with subcutaneous anti-D 50 microg/kg. The median platelet count increased from 7 x 10(9) to 31 x 10(9)/L on day 3 (P < 0.01). The median decline in hemoglobin was 1.3 g/dl. Two children experienced minor fever and chills within 24 hr of treatment. Pain at the injection site was common but self-limiting with no effect on activity level. These results suggest subcutaneous anti-D IgG 50 microg/kg as an effective and well-tolerated treatment option in childhood ITP.
Kjaersgaard
Mimi
M
Department of Pediatrics, Aarhus University Hospital Skejby, Aarhus, Denmark. mimi.kjaersgaard@ki.au.dk
Edslev
Pernille Wendtland
PW
Hasle
Henrik
H
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D023341:Chills / Q000209:etiology; D005260:Female; D005334:Fever / Q000209:etiology; D006454:Hemoglobins / Q000032:analysis; D006470:Hemorrhage / Q000209:etiology; D006801:Humans; D007167:Immunotherapy; D007223:Infant; D007279:Injections, Subcutaneous; D007518:Isoantibodies / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D010146:Pain / Q000209:etiology; D010976:Platelet Count; D011446:Prospective Studies; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000097:blood / Q000150:complications / Q000628:therapy*; D018029:Rho(D) Immune Globulin
D006454:Hemoglobins; D007518:Isoantibodies; C061961:RHO(D) antibody; D018029:Rho(D) Immune Globulin