Cancer genetic association studies in the genome-wide age.
Genome-wide association studies of hundreds of thousands of SNPs have led to a deluge of studies of genetic variation in cancer and other common diseases. Large case-control and cohort studies have identified novel SNPs as markers of cancer risk. Genome-wide association study SNP data have also advanced understanding of population-specific genetic variation. While studies of risk profiles, combinations of SNPs that may increase cancer risk, are not yet clinically applicable, future, large-scale studies will make individualized cancer screening and prevention possible.
Savage
Sharon A
SA
Clinical Genetics Branch, Division of Cancer, Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS/7018, Rockville, MD 20892, USA, Tel.: +1 301 496 5785, ,  savagesh@mail.nih.gov.