Gout. Hyperuricemia and cardiovascular disease: how strong is the evidence for a causal link?
An association between high levels of serum urate and cardiovascular disease has been proposed for many decades. However, it was only recently that compelling basic science data, small clinical trials, and epidemiological studies have provided support to the idea of a true causal effect. In this review we present recently published data that study the association between hyperuricemia and selected cardiovascular diseases, with a final conclusion about the possibility of this association being causal.
Gaffo
Angelo L
AL
Birmingham VA Medical Center, 700 19th St. S, Birmingham, AL 35233, USA. agaffo@uab.edu
Edwards
N Lawrence
NL
Saag
Kenneth G
KG
D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000209:etiology*; D006073:Gout / Q000150:complications* / Q000453:epidemiology; D006801:Humans; D033461:Hyperuricemia / Q000150:complications* / Q000453:epidemiology; D014527:Uric Acid / Q000097:blood
D014527:Uric Acid