title: Mechanical evaluation of synthetic biomaterials used in the correction of pelvic floor disorders--experimental study in rabbits.
abstract: OBJECTIVE
  To evaluate the biomechanical properties of the principal prosthetic materials currently used in genital prolapse surgery.
  
  
  METHODS
  Based on an animal model of incisional abdominal hernia, 40 adult rabbits were implanted. Four 2.5 cm x 2.5 cm parietal defects, were created in the abdominal fascia and muscles while respecting the peritoneum. For each rabbit, the defect was repaired by four different large pore size prostheses which varied according to the material used: two with monofilament of heavy (75 g/m(2)) or low (38 g/m(2)) weight polypropylene (PP), and two with multifilament of heavy (115 g/m(2)) or low (59 g/m(2)) weight polyethylene-terephthalate (PET). Animals were sacrificed in groups of 10 after 14, 30, 90 and 180 days to evaluate contraction, solidity and elasticity of the prostheses.
  
  
  RESULTS
  PP and PET retracted, independently of their weight, in 81.25% and 20% respectively. Intensity of contraction was not predictable but median value of retracted surface was 14% with PP, none with PET. Contraction settled quickly after tissue integration and did not subsequently occur. Heavyweight PET was considered the most solid material (70 N cm(-1)), low-weight PP the most fragile (20 N cm(-1)). Heavy forms of PP or PET resisted better to the rupture than the light forms which were sometimes insufficient to resist the extreme values of the human abdominal pressure (16 N cm(-1)). PP was more flexible than PET, but PET was the only form which was able to support extreme values of the abdominal pressure and remain in the elastic range. Duration of implantation did not modify solidity or elasticity of the prostheses.
  
  
  CONCLUSIONS
  In our abdominal rabbit model, as regards mechanical properties, heavyweight PET seems to be the optimal biomaterial.
authors.affiliation: Clinique Gynécologique et Obstétricale, CHU-Hôpitaux de Rouen, 76031 Rouen Cedex, France. Fabrice.Sergent@chu-rouen.fr
authors.forename: Fabrice
authors.initials: F
authors.lastname: Sergent
authors.forename: Nicolas
authors.initials: N
authors.lastname: Desilles
authors.forename: Yann
authors.initials: Y
authors.lastname: Lacoume
authors.forename: Claude
authors.initials: C
authors.lastname: Bunel
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Marie
authors.forename: Loïc
authors.initials: L
authors.lastname: Marpeau
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use*; D001696:Biomechanical Phenomena; D004548:Elasticity; D005260:Female; D013509:Gynecologic Surgical Procedures / Q000295:instrumentation* / Q000379:methods*; D008422:Materials Testing; D023421:Models, Animal; D056887:Pelvic Organ Prolapse / Q000601:surgery*; D010795:Phthalic Acids; D011126:Polypropylenes; D019736:Prostheses and Implants; D011817:Rabbits
chemical_list: D001672:Biocompatible Materials; D010795:Phthalic Acids; D011126:Polypropylenes; C011363:terephthalic acid