title: Drug loaded poly[Lac(Glc-Leu)] microparticles: formulation and release characteristics.
abstract: Valdecoxib has been entrapped in sub-5 microm particles of poly[Lac(Glc-Leu)] copolymer using a oil-in-water (o/w) emulsification-solvent evaporation technique. To achieve monodispersed sized particles, a microfluidizer was used as ultrasonication device. Formulation parameters such as effect of polymer load, ultrasonication time, stabilizer concentration and stirring rate have a profound effect on particle size, and polydispersity. By adjustment of these parameters, microparticles ranging from about 0.8 to more than 4 microm have been prepared.
authors.affiliation: Pharmaceutical Division, Institute of Chemical Technology, University of Mumbai, Nathalal Parikh Street, Matunga, Mumbai 400019, India. agnihotrisagar@hotmail.com
authors.forename: Sagar M
authors.initials: SM
authors.lastname: Agnihotri
authors.forename: Pradeep R
authors.initials: PR
authors.lastname: Vavia
mesh_terms: D002626:Chemistry, Pharmaceutical; D004339:Drug Compounding; D016503:Drug Delivery Systems; D007555:Isoxazoles / Q000494:pharmacology*; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D011091:Polyesters / Q000737:chemistry*; D013449:Sulfonamides / Q000494:pharmacology*; D013997:Time Factors; D014465:Ultrasonics; D000096926:Benzenesulfonamides
chemical_list: D007555:Isoxazoles; D011091:Polyesters; D013449:Sulfonamides; C406224:valdecoxib; D000096926:Benzenesulfonamides