title: Sirolimus-eluting versus bare-metal stent implantation in patients with ostial lesions.
abstract: BACKGROUND
  To investigate the efficacy of implantation of sirolimus-eluting stents (SES) in the ostium of coronary arteries.
  
  
  METHODS
  We assigned 96 patients with lesions located in ostias of the coronary circulation to receive a SES or a bare-metal stent (BMS).
  
  
  RESULTS
  At follow-up the late lumen loss was 0.07 mm in the SES versus 1.06 mm in the BMS group (p<0.001); -0.04 mm versus 0.11 mm (p = 0.12) in the neighbour ostium. The rate of target lesion revascularisation was 2% with SES and 39% with BMS (p<0.001), and major adverse cardiac events (MACE) 6% versus 41% (p = 0.001).
  
  
  CONCLUSIONS
  In patients with ostial coronary lesions the angiographic outcome is improved and the long-term MACE rate is low after SES compared with BMS implantation.
authors.forename: Erik
authors.initials: E
authors.lastname: Jørgensen
authors.forename: Henning
authors.initials: H
authors.lastname: Kelbæk
authors.forename: Lene
authors.initials: L
authors.lastname: Kløvgaard
authors.forename: Leif
authors.initials: L
authors.lastname: Thuesen
authors.forename: Lars R
authors.initials: LR
authors.lastname: Krusell
authors.forename: Hans E
authors.initials: HE
authors.lastname: Bøtker
authors.forename: Kari
authors.initials: K
authors.lastname: Saunamäki
authors.forename: Jens F
authors.initials: JF
authors.lastname: Lassen
authors.forename: Steffen
authors.initials: S
authors.lastname: Helqvist
mesh_terms: D054058:Acute Coronary Syndrome / Q000473:pathology / Q000628:therapy; D023903:Coronary Restenosis; D003331:Coronary Vessels / Q000473:pathology*; D054855:Drug-Eluting Stents / Q000009:adverse effects; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008670:Metals / Q000009:adverse effects; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic; D020123:Sirolimus / Q000008:administration & dosage*; D015607:Stents / Q000009:adverse effects; D013927:Thrombosis / Q000209:etiology / Q000473:pathology
chemical_list: D008670:Metals; D020123:Sirolimus