title: Significance of platelet volume indices and platelet count in ischaemic heart disease.
abstract: BACKGROUND
  Ischaemic heart disease is mainly caused by atherosclerosis and its complications. Platelets and their activity have an important role in initiation of atherosclerotic lesions and coronary thrombus formation. Larger platelets are enzymatically and metabolically more active and have a higher potential thrombotic ability as compared with smaller platelets.
  
  
  OBJECTIVE
  To study the changes in platelet volume indices and platelet count in ischaemic heart disease and assess their usefulness in predicting coronary events.
  
  
  METHODS
  This was a comparative study of 180 patients (60 patients with stable angina, 60 with acute coronary syndrome and 60 with non-cardiac chest pain). Blood venous sample were drawn from all subjects after admission (within 30 min) and collected in standardised EDTA sample tubes. Platelet count and volume indices were assayed within 30 min of blood collection, using Sysmex KX21-N autoanalyzer.
  
  
  RESULTS
  The platelet count was significantly lower in patients with acute coronary syndrome (201.28 x 10(9)/l) as compared with patients with stable angina (267.07 x 10(9)/l) and those from the normal population (256.65 x 10(9)/l) (p<0.001). In addition, patients with acute coronary syndrome had higher platelet volume indices (10.97) compared with patients in the stable angina (10.03) and normal population groups (9.12) (p<0.001).
  
  
  CONCLUSIONS
  Patients with acute coronary syndrome had higher platelet volume indices and lower platelet counts compared with those with stable angina and the normal population. Measurements of platelet volume indices and platelet count may be of some benefit in detecting those patients at higher risk for acute coronary events.
authors.affiliation: Department of Medicine, Netaji Subhash Chandra Bose Medical College, Jabalpur, India. drranjithmp@gmail.com
authors.forename: M P
authors.initials: MP
authors.lastname: Ranjith
authors.forename: R
authors.initials: R
authors.lastname: Divya
authors.forename: V K
authors.initials: VK
authors.lastname: Mehta
authors.forename: M G
authors.initials: MG
authors.lastname: Krishnan
authors.forename: R
authors.initials: R
authors.lastname: KamalRaj
authors.forename: Arvind
authors.initials: A
authors.lastname: Kavishwar
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood / Q000209:etiology; D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000097:blood; D001241:Aspirin / Q000494:pharmacology; D001792:Blood Platelets / Q000187:drug effects / Q000473:pathology*; D048429:Cell Size; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood* / Q000150:complications; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D010976:Platelet Count; D011379:Prognosis; D011446:Prospective Studies
chemical_list: D010975:Platelet Aggregation Inhibitors; D001241:Aspirin