title: TCF7L2 polymorphism associates with new-onset diabetes after transplantation.
abstract: New-onset diabetes after transplantation (NODAT) is a serious and frequent complication in transplant recipients. Whether NODAT shares the same susceptibility genes as type 2 diabetes is unknown. In this multicenter study, we genotyped 1076 white patients without diabetes at transplantation for 11 polymorphisms that associate with type 2 diabetes. We defined NODAT as a fasting plasma glucose > or =126 mg/dl on at least two occasions or de novo hypoglycemic therapy. We compared clinical and genetic factors between patients who developed NODAT within 6 mo of transplantation (n = 118; incidence 11%) and patients without diabetes (n = 958). In multivariate analysis, NODAT significantly associated with the following characteristics: TCF7L2 polymorphism (odds ratio [OR] 1.60 per each T allele; P = 0.002), age (OR 1.03 per year; P < 0.001), body mass index at transplantation (OR 1.09 per unit; P < 0.001), tacrolimus use (OR 2.26; P < 0.001), and the occurrence of a corticoid-treated acute rejection episode (OR 2.78; P < 0.001). In summary, our data show that the TCF7L2 rs7903146 polymorphism, a known risk factor for type 2 diabetes in the general population, also associates with NODAT.
authors.affiliation: Clinique de Transplantation Rénale, Hôpital Erasme-ULB, 1070 Bruxelles, Belgique. lghisdal@yahoo.com
authors.forename: Lidia
authors.initials: L
authors.lastname: Ghisdal
authors.forename: Christophe
authors.initials: C
authors.lastname: Baron
authors.forename: Yannick
authors.initials: Y
authors.lastname: Le Meur
authors.forename: Arnaud
authors.initials: A
authors.lastname: Lionet
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Halimi
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Rerolle
authors.forename: François
authors.initials: F
authors.lastname: Glowacki
authors.forename: Yvon
authors.initials: Y
authors.lastname: Lebranchu
authors.forename: Mireille
authors.initials: M
authors.lastname: Drouet
authors.forename: Christian
authors.initials: C
authors.lastname: Noël
authors.forename: Hakim
authors.initials: H
authors.lastname: El Housni
authors.forename: Pascale
authors.initials: P
authors.lastname: Cochaux
authors.forename: Karl Martin
authors.initials: KM
authors.lastname: Wissing
authors.forename: Daniel
authors.initials: D
authors.lastname: Abramowicz
authors.forename: Marc
authors.initials: M
authors.lastname: Abramowicz
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005260:Female; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011183:Postoperative Complications / Q000209:etiology*; D051820:TCF Transcription Factors / Q000235:genetics*; D058118:Transcription Factor 7-Like 2 Protein
chemical_list: D051820:TCF Transcription Factors; C544894:TCF7L2 protein, human; D058118:Transcription Factor 7-Like 2 Protein