Identification of a polyprenylphosphomannosyl synthase involved in the synthesis of mycobacterial mannosides.
We report on the identification of a glycosyltransferase (GT) from Mycobacterium tuberculosis H37Rv, Rv3779, of the membranous GT-C superfamily responsible for the direct synthesis of polyprenyl-phospho-mannopyranose and thus indirectly for lipoarabinomannan, lipomannan, and the higher-order phosphatidyl-myo-inositol mannosides.
Scherman
Hataichanok
H
Department of Microbiology, Colorado State University, Fort Collins, Colorado 80523-1682, USA.
Kaur
Devinder
D
Pham
Ha
H
Skovierová
Henrieta
H
Jackson
Mary
M
Brennan
Patrick J
PJ
D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D015964:Gene Expression Regulation, Bacterial / Q000502:physiology; D015971:Gene Expression Regulation, Enzymologic / Q000502:physiology; D016695:Glycosyltransferases / Q000378:metabolism*; D008070:Lipopolysaccharides / Q000096:biosynthesis; D008362:Mannosides / Q000096:biosynthesis; D005810:Multigene Family; D009154:Mutation; D009169:Mycobacterium tuberculosis / Q000201:enzymology* / Q000648:ultrastructure
D001426:Bacterial Proteins; D008070:Lipopolysaccharides; D008362:Mannosides; C050016:lipoarabinomannan; C064351:lipomannan; D016695:Glycosyltransferases