title: Possible association of atrophic gastritis and arterial stiffness in healthy middle-aged Japanese.
abstract: OBJECTIVE
  Helicobacter pylori (HP) has been implicated as a risk factor for cardiovascular and atherosclerotic diseases. Arterial stiffness determined by pulse wave velocity (PWV) or the cardio-ankle vascular index (CAVI) has been shown to be higher in HP-positive subjects than in HP-negative subjects; however, this result has been observed only in young subjects. The aim of the study was to investigate the possible correlation between HP infection and PWV or CAVI in middle-aged subjects.
  
  
  METHODS
  We measured brachial-ankle PWV (baPWV), CAVI, metabolism markers, pepsinogens (PGs) and IgG antibody to HP in 343 individuals aged either 60 or 65 year old. Atrophic gastritis (AG) was diagnosed based on the values of PGs.
  
  
  RESULTS
  baPWV and CAVI were significantly higher in the AG-positive group than in the AG-negative group even after adjusting for possible confounding factors (baPWVc; 16.63+/-3.50 vs. 15.59+/-3.47 p=0.010, CAVIc; 8.59+/-1.20 vs. 8.27+/-1.19 p=0.022). baPWV and CAVI values tended to be higher in the HP-positive group than in the HP-negative group. High-density lipoprotein (HDL) cholesterol level and the adiponectin level were lower in the AG-positive group than in the AG-negative group.
  
  
  CONCLUSIONS
  There may be an association between atrophic gastritis and atherosclerosis in middle-aged subjects.
authors.affiliation: Division of General Internal Medicine, Kyushu Dental College, Japan. r07torisu@fa.kyu-dent.ac.jp
authors.forename: Takehiro
authors.initials: T
authors.lastname: Torisu
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Takata
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Ansai
authors.forename: Takayuki
authors.initials: T
authors.lastname: Matsumoto
authors.forename: Kazuo
authors.initials: K
authors.lastname: Sonoki
authors.forename: Inho
authors.initials: I
authors.lastname: Soh
authors.forename: Shuji
authors.initials: S
authors.lastname: Awano
authors.forename: Akihiro
authors.initials: A
authors.lastname: Yoshida
authors.forename: Tomoko
authors.initials: T
authors.lastname: Hamasaki
authors.forename: Shuntaro
authors.initials: S
authors.lastname: Kagiyama
authors.forename: Ikuo
authors.initials: I
authors.lastname: Nakamichi
authors.forename: Tomoko
authors.initials: T
authors.lastname: Ohsumi
authors.forename: Kuniaki
authors.initials: K
authors.lastname: Toyoshima
authors.forename: Tatsuji
authors.initials: T
authors.lastname: Nishihara
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Iida
authors.forename: Tadamichi
authors.initials: T
authors.lastname: Takehara
mesh_terms: D000368:Aged; D001158:Arteries / Q000503:physiopathology*; D003187:Compliance; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005757:Gastritis, Atrophic / Q000150:complications* / Q000382:microbiology; D016480:Helicobacter pylori / Q000302:isolation & purification; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D014652:Vascular Diseases / Q000150:complications* / Q000503:physiopathology