pH-responsive mechanised nanoparticles gated by semirotaxanes.
A [2]pseudorotaxane-based mechanised nanoparticle system, which operates within an aqueous acidic environment, has been prepared and characterised; this integrated system affords both water-soluble stalk and ring components in an effort to improve the biocompatibility of these promising new drug delivery vehicles.
Khashab
Niveen M
NM
Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA.
Belowich
Matthew E
ME
Trabolsi
Ali
A
Friedman
Douglas C
DC
Valente
Cory
C
Lau
Yuen
Y
Khatib
Hussam A
HA
Zink
Jeffrey I
JI
Stoddart
J Fraser
JF
D001672:Biocompatible Materials / Q000737:chemistry; D001952:Bridged-Ring Compounds / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods*; D006863:Hydrogen-Ion Concentration; D007093:Imidazoles / Q000737:chemistry; D047028:Macrocyclic Compounds / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D053758:Nanoparticles / Q000737:chemistry*; D012235:Rhodamines / Q000737:chemistry; D043862:Rotaxanes / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry; D013050:Spectrometry, Fluorescence; D014755:Viologens / Q000737:chemistry; D000099246:Cucurbit(n)urils
D001672:Biocompatible Materials; D001952:Bridged-Ring Compounds; D007093:Imidazoles; D047028:Macrocyclic Compounds; D012235:Rhodamines; D043862:Rotaxanes; D012822:Silicon Dioxide; D014755:Viologens; C454805:cucurbit(6)uril; D000099246:Cucurbit(n)urils; C029773:rhodamine B