title: Age-related ENOX protein (arNOX) activity correlated with oxidative skin damage in the elderly.
abstract: ENOX proteins with an oscillatory pattern of production of superoxide (measured by ferricytochrome c reduction) and with a period length of 26 min increase linearity with age beginning at about 30 y to a maximum of about age 60. The proteins are shed and appear in serum, saliva and urine. Enhanced arNOX activity correlates with age and with oxidative changes contributing to skin aging. Topical cosmetic preparations containing substances that block arNOX activity are under evaluation to reduce visible symptoms of skin aging.
authors.affiliation: Department of Foods and Nutrition, Purdue University, West Lafayette, IN 47907-2059, USA. morredm@purdue.edu
authors.forename: Dorothy M
authors.initials: DM
authors.lastname: Morré
authors.forename: Christaan
authors.initials: C
authors.lastname: Meadows
authors.forename: Brandon
authors.initials: B
authors.lastname: Hostetler
authors.forename: Nicole
authors.initials: N
authors.lastname: Weston
authors.forename: Dale
authors.initials: D
authors.lastname: Kern
authors.forename: Zoe
authors.initials: Z
authors.lastname: Draelos
authors.forename: D James
authors.initials: DJ
authors.lastname: Morré
mesh_terms: D000367:Age Factors; D000368:Aged; D000375:Aging / Q000502:physiology*; D045304:Cytochromes c / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009247:NADH, NADPH Oxidoreductases / Q000378:metabolism*; D018384:Oxidative Stress / Q000502:physiology*; D012867:Skin / Q000378:metabolism* / Q000473:pathology; D015595:Skin Aging / Q000502:physiology; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D045304:Cytochromes c; D013482:Superoxide Dismutase; D009247:NADH, NADPH Oxidoreductases; C431909:tumor-associated NADH oxidase