title: Diffusion-weighted imaging of breast cancer: correlation of the apparent diffusion coefficient value with prognostic factors.
abstract: OBJECTIVE
  To evaluate the role of diffusion-weighted imaging (DWI) in the detection of breast cancers, and to correlate the apparent diffusion coefficient (ADC) value with prognostic factors.
  
  
  METHODS
  Sixty-seven women with invasive cancer underwent breast MRI. Histological specimens were analyzed for tumor size and grade, and expression of estrogen receptors (ER), progesterone receptors, c-erbB-2, p53, Ki-67, and epidermal growth factor receptors. The computed mean ADC values of breast cancer and normal breast parenchyma were compared. Relationships between the ADC values and prognostic factors were determined using Wilcoxon signed rank test and Kruskal-Wallis test.
  
  
  RESULTS
  DWI detected breast cancer as a hyperintense area in 62 patients (92.5 %). A statistically significant difference in the mean ADC values of breast cancer (1.09 +/- 0.27 x 10(-5) mm(2)/s) and normal parenchyma (1.59 +/- 0.27 x 10(-5) mm(2)/s) was detected (P < 0.0001). There were no correlations between the ADC value and prognostic factors. However, the median ADC value was lower in the ER-positive group than the ER negative group, and this difference was marginally significant (1.09 x 10(-5) mm(2)/s versus 1.15 x 10(-5) mm(2)/s, P = 0.053).
  
  
  CONCLUSIONS
  The ADC value was a helpful parameter in detecting malignant breast tumors, but ADC value could not predict patient prognosis.
authors.affiliation: Department of Radiology, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Sung Hun
authors.initials: SH
authors.lastname: Kim
authors.forename: Eun Suk
authors.initials: ES
authors.lastname: Cha
authors.forename: Hyeon Sook
authors.initials: HS
authors.lastname: Kim
authors.forename: Bong Joo
authors.initials: BJ
authors.lastname: Kang
authors.forename: Jae Jeong
authors.initials: JJ
authors.lastname: Choi
authors.forename: Ji Han
authors.initials: JH
authors.lastname: Jung
authors.forename: Yong Gyu
authors.initials: YG
authors.lastname: Park
authors.forename: Young Jin
authors.initials: YJ
authors.lastname: Suh
mesh_terms: D000328:Adult; D000369:Aged, 80 and over; D001940:Breast / Q000473:pathology / Q000648:ultrastructure; D001943:Breast Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000648:ultrastructure; D018270:Carcinoma, Ductal, Breast / Q000175:diagnosis / Q000473:pathology* / Q000648:ultrastructure; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D017352:Echo-Planar Imaging / Q000379:methods; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis