title: Circulating vitamin d and risk of epithelial ovarian cancer.
abstract: We conducted a nested case-control study within two prospective cohorts, the New York University Women's Health Study and the Northern Sweden Health and Disease Study, to examine the association between prediagnostic circulating levels of 25-hydroxy vitamin D (25(OH)D) and the risk of subsequent invasive epithelial ovarian cancer (EOC). The 25(OH)D levels were measured in serum or plasma from 170 incident cases of EOC and 373 matched controls. Overall, circulating 25(OH)D levels were not associated with the risk of EOC in combined cohort analysis: adjusted OR for the top tertile versus the reference tertile, 1.09 (95% CI, 0.59-2.01). In addition, there was no evidence of an interaction effect between VDR SNP genotype or haplotype and circulating 25(OH)D levels in relation to ovarian cancer risk, although more complex gene-environment interactions may exist.
authors.affiliation: Department of Environmental Medicine, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA.
authors.forename: Alan A
authors.initials: AA
authors.lastname: Arslan
authors.forename: Tess V
authors.initials: TV
authors.lastname: Clendenen
authors.forename: Karen L
authors.initials: KL
authors.lastname: Koenig
authors.forename: Johan
authors.initials: J
authors.lastname: Hultdin
authors.forename: Kerstin
authors.initials: K
authors.lastname: Enquist
authors.forename: Asa
authors.initials: A
authors.lastname: Agren
authors.forename: Annekatrin
authors.initials: A
authors.lastname: Lukanova
authors.forename: Hubert
authors.initials: H
authors.lastname: Sjodin
authors.forename: Anne
authors.initials: A
authors.lastname: Zeleniuch-Jacquotte
authors.forename: Roy E
authors.initials: RE
authors.lastname: Shore
authors.forename: Göran
authors.initials: G
authors.lastname: Hallmans
authors.forename: Paolo
authors.initials: P
authors.lastname: Toniolo
authors.forename: Eva
authors.initials: E
authors.lastname: Lundin