title: Preemptive antimycotic treatment in critically ill patients in the Czech Republic.
abstract: The incidence of Candida afflictions in critically ill patients is still growing in the Czech Republic. We looked for a method that not only decreases Candida afflictions but also decreases treatment expenses. This method is preemptive therapy. Critically ill patients were determined by a risk score system. This system was based on summarizing all the risk factors in one patient. Patients who reach the risk score were randomized into groups A and B. Patients in group A were administered itraconazole; patients in group B were not administered any antimycotics. Results of the study show that preemptive treatment decreases Candida infection and Candidemia. A decrease of treatment expenses was reached by identifying the specific group of patients at risk using the risk score system and administering antimycotics.
authors.affiliation: Department of Surgery, Institute of Medical Studies, Pardubice General Hospital, Pardubice, Czech Republic.
authors.forename: K
authors.initials: K
authors.lastname: Havlicek
authors.forename: V
authors.initials: V
authors.lastname: Cervinka
authors.forename: L
authors.initials: L
authors.lastname: Sakra
authors.forename: V
authors.initials: V
authors.lastname: Motycka
authors.forename: K
authors.initials: K
authors.lastname: Mencl
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use*; D002177:Candidiasis / Q000517:prevention & control*; D016638:Critical Illness; D003428:Cross Infection / Q000517:prevention & control*; D018153:Czech Republic; D005260:Female; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use*; D008297:Male; D011446:Prospective Studies
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole