title: Peripheral distribution of amoxicillin in sheep and influence of local inflammation.
abstract: The pharmacokinetics of amoxicillin (AMX) in blood serum (SBS) and tissue cage fluid (TCF) was studied in sheep. Four tissue cages, prepared from silicone rubber tubing, were subcutaneously inserted in the neck area (two on each side) of the experimental animals and AMX was administered both intravenously (IV) and intramuscularly (IM) at the dose rate of 15mg/kg bodyweight. The impact of local inflammation on AMX distribution in TCF was studied after intra-cavity injection of a lambda carrageenan solution in one of the two tissue cages used after each administration. In contrast to the three-compartment AMX disposition after IV injection, two-compartment, absorption-limited pharmacokinetics was observed after IM administration. Non-inflamed and inflamed TCF data revealed, in all cases, the attainment of low, but prolonged concentrations and absence of an inflammation-induced effect on AMX penetration into and elimination from TCF.
authors.affiliation: Laboratory of Pharmacology, Faculty of Veterinary Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors.forename: Georgios A
authors.initials: GA
authors.lastname: Delis
authors.forename: Maria
authors.initials: M
authors.lastname: Koutsoviti-Papadopoulou
authors.forename: Ekaterini
authors.initials: E
authors.lastname: Theodosiadou
authors.forename: Georgios
authors.initials: G
authors.lastname: Kounenis
authors.forename: Georgios C
authors.initials: GC
authors.lastname: Batzias
mesh_terms: D000658:Amoxicillin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D015194:Diffusion Chambers, Culture; D007249:Inflammation / Q000378:metabolism / Q000662:veterinary; D007273:Injections, Intramuscular / Q000662:veterinary; D007275:Injections, Intravenous; D012756:Sheep; D012757:Sheep Diseases / Q000378:metabolism*; D014018:Tissue Distribution
chemical_list: D000900:Anti-Bacterial Agents; D000658:Amoxicillin