title: Health of children born to mothers who had preeclampsia: a population-based cohort study.
abstract: OBJECTIVE
  We assessed whether preeclampsia correlates with the long-term postnatal health of the offspring.
  
  
  METHODS
  We conducted a population-based cohort study of 1,618,481 singletons born in Denmark (1978-2004) with up to 27 years of follow-up. We used Cox regression to estimate the associations between preeclampsia and long-term health outcomes of the offspring.
  
  
  RESULTS
  Children born at term exposed to preeclampsia had an increased risk of a variety of diseases, such as endocrine, nutritional, and metabolic diseases (incidence rate ratio, 1.6; 95% confidence interval, 1.5-1.7), and diseases of the blood and blood-forming organs (incidence rate ratio, 1.5; 95% confidence interval, 1.3-1.8). Children born preterm exposed to preeclampsia had a similar pattern of hospitalizations compared with the children born preterm unexposed to preeclampsia, although they had a decreased risk of cerebral palsy (incidence rate ratio, 0.7; 95% confidence interval, 0.6-0.9).
  
  
  CONCLUSIONS
  Preeclampsia was associated with an increased risk of being hospitalized for a number of diseases, especially in the children born at term.
authors.affiliation: Department of Epidemiology, School of Public Health, University of Aarhus, Aarhus, Denmark. cw@soci.au.dk
authors.forename: Chun S
authors.initials: CS
authors.lastname: Wu
authors.forename: Ellen A
authors.initials: EA
authors.lastname: Nohr
authors.forename: Bodil H
authors.initials: BH
authors.lastname: Bech
authors.forename: Mogens
authors.initials: M
authors.lastname: Vestergaard
authors.forename: Janet M
authors.initials: JM
authors.lastname: Catov
authors.forename: Jørn
authors.initials: J
authors.lastname: Olsen
mesh_terms: D003718:Denmark / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D005865:Gestational Age; D006304:Health Status; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011225:Pre-Eclampsia / Q000453:epidemiology*; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology*; D011297:Prenatal Exposure Delayed Effects / Q000453:epidemiology*; D018570:Risk Assessment