Bioactive triterpenes from Diospyros blancoi.
The ethyl acetate extract of the air-dried leaves of Diospyros blancoi afforded isoarborinol methyl ether (1), a mixture of alpha-amyrin palmitate, alpha-amyrin palmitoleate, beta-amyrin palmitate and beta-amyrin palmitoleate (2) in a 13 : 4 : 3 : 1 ratio, and squalene. The structures of 1, 2 and squalene were elucidated by extensive 1D and 2D NMR spectroscopy. Compounds 1 and 2 exhibited antimicrobial activity against Escherichia coli, Pseudomonas aeruginosa, Candida albicans, Staphylococcus aureus and Trichophyton mentagrophytes, and were found inactive against Bacillus subtilis and Aspergillus niger. Sample 2 exhibited significant analgaesic and anti-inflammatory activities.
Ragasa
Consolacion Y
CY
Chemistry Department, Center for Natural Sciences and Ecological Research, De La Salle University, 1004 Manila, Philippines. ragasac@dlsu.edu.ph
Puno
Marc Rhyan Anthony
MR
Sengson
Josephine Marie Angeline P
JM
Shen
Chien-Chang
CC
Rideout
John A
JA
Raga
Dennis D
DD
D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology*; D001234:Aspergillus niger / Q000187:drug effects; D001412:Bacillus subtilis / Q000187:drug effects; D001419:Bacteria / Q000187:drug effects*; D002176:Candida albicans / Q000187:drug effects; D029788:Diospyros / Q000737:chemistry*; D004926:Escherichia coli / Q000187:drug effects; D005658:Fungi / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013211:Staphylococcus aureus / Q000187:drug effects; D014249:Trichophyton / Q000187:drug effects; D014315:Triterpenes / Q000737:chemistry* / Q000494:pharmacology*
D000890:Anti-Infective Agents; D014315:Triterpenes