Feline injection-site sarcoma: recurrence, tumour grading and surgical margin status evaluated using the three-dimensional histological technique.
The three-dimensional histology technique is used in human medicine for the evaluation of complete lateral and deep surgical margins. In this study, the technique was applied to 48 excised feline injection-site sarcoma specimens. The predictive value of the histological margin status and tumour grading on local recurrence was investigated. In 32/48 cases, the margins were non-infiltrated, whilst in the remaining 16 cases, they were infiltrated. Overall, 6/32 (19%) tumours with non-infiltrated margins and 11/16 (69%) with infiltrated margins recurred. Tumours with infiltrated margins recurred about 10 times more frequently compared to tumours with non-infiltrated margins (P=0.0011). No statistically significant correlation was observed between grading and recurrence. The assessment of margin status using the 3D histology technique showed a good predictivity for post-surgical tumour recurrence. Extensive application of the 3D histology technique is recommended to standardise the evaluation of histological margins and to allow comparison between results from different laboratories.
Giudice
Chiara
C
Department of Animal Pathology, Hygiene and Public Health, Faculty of Veterinary Medicine, Università degli Studi di Milano, Italy. chiara.giudice@unimi.it
Stefanello
Damiano
D
Sala
Marcello
M
Cantatore
Matteo
M
Russo
Fulvia
F
Romussi
Stefano
S
Travetti
Olga
O
Di Giancamillo
Mauro
M
Grieco
Valeria
V
D000818:Animals; D002371:Cat Diseases / Q000473:pathology* / Q000601:surgery; D002415:Cats; D005260:Female; D005500:Follow-Up Studies; D006652:Histological Techniques / Q000379:methods / Q000662:veterinary*; D007267:Injections / Q000662:veterinary; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000662:veterinary; D018365:Neoplasm, Residual; D011237:Predictive Value of Tests; D012509:Sarcoma / Q000473:pathology / Q000601:surgery / Q000662:veterinary*; D012878:Skin Neoplasms / Q000473:pathology / Q000601:surgery / Q000662:veterinary*