Neuroleptic malignant syndrome and acute motor axonal neuropathy after Campylobacter jejuni infection.
We report the case of a patient with Parkinson's disease who developed rapidly progressive weakness of the four limbs due to an acute motor axonal neuropathy (AMAN). This occurred days after a neuroleptic malignant syndrome (NMS). Serologic evidence of a preceding Campylobacter jejuni infection was detected and treatment with intravenous immunoglobulins proved effective. This case suggests that the rarely described neuropathies occurring with NMS may have a postinfectious immune basis and respond to immunomodulatory therapy.
Rajabally
Y A
YA
Department of Neurology, Neuromuscular Clinic, Leicester General Hospital, University Hospitals of Leicester, Leicester LE5 4PW, United Kingdom. yusuf.rajabally@uhl-tr.nhs.uk
Ramlackhansingh
A
A
Fraser
M
M
Abbott
R J
RJ
D000907:Antibodies, Bacterial / Q000097:blood / Q000276:immunology; D000978:Antiparkinson Agents / Q000009:adverse effects / Q000627:therapeutic use; D002169:Campylobacter Infections / Q000150:complications* / Q000175:diagnosis; D016123:Campylobacter jejuni; D004576:Electromyography; D005334:Fever / Q000209:etiology; D005677:G(M1) Ganglioside / Q000276:immunology; D020275:Guillain-Barre Syndrome / Q000209:etiology* / Q000628:therapy; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D007075:Immunoglobulin M / Q000097:blood / Q000276:immunology; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D008070:Lipopolysaccharides / Q000276:immunology; D008297:Male; D008875:Middle Aged; D018716:Molecular Mimicry; D009431:Neural Conduction; D009459:Neuroleptic Malignant Syndrome / Q000209:etiology*; D010300:Parkinson Disease / Q000150:complications* / Q000188:drug therapy; D011782:Quadriplegia / Q000209:etiology*; D014474:Unconsciousness / Q000209:etiology
D000907:Antibodies, Bacterial; D000978:Antiparkinson Agents; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D016756:Immunoglobulins, Intravenous; D008070:Lipopolysaccharides; D005677:G(M1) Ganglioside