Disorders of placental circulation and the fetal brain.
Disorders of the placental circulation, including the release of deleterious mediators to the fetus, are important risk factors for central nervous system complications. These disorders result in discrete patterns of placental injury detectable by a thorough placental pathologic examination. Consideration of the location, severity, multiplicity, and timing of these lesions is critical to a full understanding of their significance. Less than 10% of placentas from term infants that later develop cerebral palsy lack any evidence of placental abnormalities potentially related to adverse outcome.
Redline
Raymond W
RW
Department of Pathology, Case Western Reserve University School of Medicine, OH 44106, USA. raymondw.redline@UHhospitals.org
D001925:Brain Damage, Chronic / Q000473:pathology*; D002547:Cerebral Palsy / Q000473:pathology; D005260:Female; D005315:Fetal Diseases / Q000473:pathology*; D006801:Humans; D007231:Infant, Newborn; D010922:Placenta Diseases / Q000473:pathology*; D021041:Placental Circulation; D010927:Placental Insufficiency / Q000473:pathology*; D011247:Pregnancy; D012307:Risk Factors