title: Cardiac transplant in a child with recurrent thrombosis due to congenital thrombophilic mutations.
abstract: A modified Blalock-Taussig shunt had been implanted 3 times to treat cyanosis to a patient who has uncorrectable congenital cardiac deformity. We repaired the entire pulmonary artery, from one hilus to the other, to prevent future stenosis while making cardiac transplant. Our patient was also heterozygous for 2 thrombophilic mutations: methylene tetrahydrofolate reductase C677T and Factor V A4070G. Congenital risk factors should be evaluated in patients who have experienced a thromboembolic event before cardiac surgery.
authors.affiliation: Department of Cardiovascular Surgery, Baskent University School of Medicine, Ankara, Turkey.
authors.forename: Suleyman
authors.initials: S
authors.lastname: Ozkan
authors.forename: F Belgin
authors.initials: FB
authors.lastname: Atac
authors.forename: Salih
authors.initials: S
authors.lastname: Ozcobanoglu
authors.forename: Emrah
authors.initials: E
authors.lastname: Uguz
authors.forename: Atilla
authors.initials: A
authors.lastname: Sezgin
authors.forename: Hasibe
authors.initials: H
authors.lastname: Verdi
authors.forename: Namik
authors.initials: N
authors.lastname: Ozbek
authors.forename: Sait
authors.initials: S
authors.lastname: Aslamaci
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use; D001777:Blood Coagulation / Q000235:genetics; D006348:Cardiac Surgical Procedures / Q000009:adverse effects*; D002648:Child; D005165:Factor V / Q000235:genetics*; D006330:Heart Defects, Congenital / Q000097:blood / Q000150:complications / Q000601:surgery*; D016027:Heart Transplantation; D006579:Heterozygote; D006801:Humans; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D009154:Mutation; D011651:Pulmonary Artery / Q000601:surgery; D012008:Recurrence; D012086:Reoperation; D012307:Risk Factors; D019851:Thrombophilia / Q000097:blood / Q000151:congenital / Q000235:genetics*; D013927:Thrombosis / Q000097:blood / Q000235:genetics*; D016896:Treatment Outcome
chemical_list: D000925:Anticoagulants; C095381:factor V Leiden; D005165:Factor V; D042965:Methylenetetrahydrofolate Reductase (NADPH2)