title: Efficacy and tolerability of nonpenetrating filtering surgery in the treatment of open-angle glaucoma: a meta-analysis.
abstract: OBJECTIVE
  To evaluate the efficacy and tolerability of nonpenetrating filtering surgery in the treatment of patients with open-angle glaucoma.
  
  
  METHODS
  Pertinent studies were selected by extensive searches. A total of 17 randomized controlled trials were included in the present meta-analysis. The main outcome measures were risk differences (RDs) of complete success for efficacy and postoperative complications for tolerability. Pooled estimates were computed according to a random-effects model.
  
  
  RESULTS
  Viscocanalostomy and deep sclerectomy were significantly less effective than tra- beculectomy, and pooled RDs of complete success were -0.16 (95% confidence interval, CI, -0.30 to -0.02) and -0.10 (-0.19 to 0.00). Deep sclerectomy plus mitomycin C (MMC) was also less effective than trabeculectomy plus MMC, with pooled RD of complete success being -0.16 (95% CI -0.32 to -0.01). Viscocanalostomy and deep sclerectomy caused main complications in fewer patients than trabeculectomy.
  
  
  CONCLUSIONS
  Viscocanalostomy and deep sclerectomy were less effective than trabeculectomy in the treatment of open-angle glaucoma, and deep sclerectomy plus MMC was also less effective than trabeculectomy plus MMC. However, viscocanalostomy and deep sclerectomy were associated with fewer complications than trabeculectomy.
authors.affiliation: Department of Ophthalmology, Changzheng Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Jin-Wei
authors.initials: JW
authors.lastname: Cheng
authors.forename: Gui-Lin
authors.initials: GL
authors.lastname: Xi
authors.forename: Rui-Li
authors.initials: RL
authors.lastname: Wei
authors.forename: Ji-Ping
authors.initials: JP
authors.lastname: Cai
authors.forename: You
authors.initials: Y
authors.lastname: Li
mesh_terms: D003131:Combined Modality Therapy; D005902:Glaucoma, Open-Angle / Q000601:surgery*; D006801:Humans; D016685:Mitomycin / Q000008:administration & dosage; D011183:Postoperative Complications; D016032:Randomized Controlled Trials as Topic; D012599:Sclerostomy; D014129:Trabecular Meshwork / Q000601:surgery*; D014130:Trabeculectomy; D016896:Treatment Outcome
chemical_list: D016685:Mitomycin