title: Evidence of an accelerating increase in prevalence of diagnosed Type 2 diabetes in British men, 1978-2005.
abstract: BACKGROUND
  The prevalence of Type 2 diabetes is increasing worldwide; predictions suggest that the disease will reach epidemic proportions this century. This study aims to estimate the extent of the increase in prevalence of diagnosed Type 2 diabetes in British men between 1978 and 2005.
  
  
  METHODS
  A representative cohort of 7722 British men aged 40-59 years at entry in 1978-1980 were selected from general practices in 24 British towns. Seven sequential questionnaire surveys were carried out between 1978 and 2005, recording recall of a doctor diagnosis of diabetes at each time point. Logistic regression models with generalized estimating equations were fitted to provide age-adjusted estimates of the calendar year increases in odds of Type 2 diabetes, both overall and for consecutive periods, each of approximately 5 years.
  
  
  RESULTS
  The crude prevalence of Type 2 diabetes increased from 1.2% in 1978-1980 to 12.1% in 2005. The age-adjusted average annual increase in Type 2 diabetes prevalence for the 27-year study period was 7.0% [95% confidence interval (CI) 5.4%, 8.6%]. However, the age-adjusted annual rate of increase increased over time, from 4.3% (95% CI 0.4%, 8.2%) between 1979 and 1984 to 11.8% (95% CI 8.4%, 15.4%) between 2003 and 2005; P (trend) = 0.01. The highest annual increases occurred in subjects with higher mean body mass index levels and in towns in Scotland.
  
  
  CONCLUSIONS
  The prevalence of Type 2 diabetes has risen substantially in Britain during the last three decades; the recent rate of increase has been almost three times greater than that in the early 1980s.
authors.affiliation: Research Department of Primary Care and Population Health, University College London, UK. mary.thomas@pcps.ucl.ac.uk
authors.forename: M C
authors.initials: MC
authors.lastname: Thomas
authors.forename: S L
authors.initials: SL
authors.lastname: Hardoon
authors.forename: A O
authors.initials: AO
authors.lastname: Papacosta
authors.forename: R W
authors.initials: RW
authors.lastname: Morris
authors.forename: S G
authors.initials: SG
authors.lastname: Wannamethee
authors.forename: A
authors.initials: A
authors.lastname: Sloggett
authors.forename: P H
authors.initials: PH
authors.lastname: Whincup
mesh_terms: D000328:Adult; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology*; D005500:Follow-Up Studies; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D011795:Surveys and Questionnaires; D013997:Time Factors; D006113:United Kingdom / Q000453:epidemiology