title: Comparison of transient elastography and liver biopsy for the assessment of liver fibrosis in HIV/hepatitis C virus-coinfected patients and correlation with noninvasive serum markers.
abstract: Transient elastography (FibroScan) is a novel, rapid and noninvasive technique to assess liver fibrosis. Our objective was to compare transient elastography (TE) and other noninvasive serum indexes as alternatives to liver biopsy in HIV/hepatitis C virus (HCV)-coinfected patients. The fibrosis stage (METAVIR Score), TE, the aspartate aminotransferase-to-platelet ratio index, the Forns fibrosis index, FIB-4 and HGM-2 indexes were assessed in 100 patients between January 2007 and January 2008. The diagnostic values were compared by calculating the area under the receiver operating characteristic curves (AUROCs). Using TE, the AUROC (95% CI) of liver stiffness was 0.80 (0.72-0.89) when discriminating between F <or= 1 and F > 2, 0.93 (0.85-1.00) when discriminating between F <or= 2 and F > 3 and 0.99 (0.97-1.00) when discriminating between F <or= 3 and F4. For the diagnosis of F >or= 3, the AUROCs of TE were significantly higher than those obtained with the other four noninvasive indexes. Based on receiver operating characteristic curves, three cutoff values were chosen to identify F <or= 1 (<7 kPa), F >or= 3 (>or=11 kPa) and F4 (>or=14 kPa). Using these best cutoff scores, the negative predictive value and positive predictive value were 81.1% and 70.2% for the diagnosis of F <or= 1, 96.3% and 60% for the diagnosis of F >or= 3 and 100% and 57.1% for the diagnosis of F4. Thus, Transient elastography accurately predicted liver fibrosis and outperformed other simple noninvasive indexes in HIV/HCV-coinfected patients. Our data suggest that TE is a helpful tool for guiding therapeutic decisions in clinical practice.
authors.affiliation: Unidad de Enfermedades Infecciosas/VIH (4100), Hospital Gregorio Marañón, Madrid, Spain. msconde@gmail.com
authors.forename: M
authors.initials: M
authors.lastname: Sánchez-Conde
authors.forename: M L
authors.initials: ML
authors.lastname: Montes-Ramírez
authors.forename: P
authors.initials: P
authors.lastname: Miralles
authors.forename: J M Castro
authors.initials: JM
authors.lastname: Alvarez
authors.forename: J M
authors.initials: JM
authors.lastname: Bellón
authors.forename: M
authors.initials: M
authors.lastname: Ramírez
authors.forename: J R
authors.initials: JR
authors.lastname: Arribas
authors.forename: I
authors.initials: I
authors.lastname: Gutiérrez
authors.forename: J C
authors.initials: JC
authors.lastname: López
authors.forename: J
authors.initials: J
authors.lastname: Cosín
authors.forename: E
authors.initials: E
authors.lastname: Alvarez
authors.forename: J
authors.initials: J
authors.lastname: González
authors.forename: J
authors.initials: J
authors.lastname: Berenguer
mesh_terms: D000328:Adult; D015415:Biomarkers; D001706:Biopsy; D054459:Elasticity Imaging Techniques; D015658:HIV Infections / Q000150:complications*; D019698:Hepatitis C, Chronic / Q000150:complications* / Q000473:pathology*; D006801:Humans; D008103:Liver Cirrhosis / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012372:ROC Curve; D013223:Statistics as Topic
chemical_list: D015415:Biomarkers