title: Bonding ability evaluation of bone cement on the cortical surface of rabbit's tibia.
abstract: A composite bone cement designated G2B1 that contains beta tricalcium phosphate particles was developed as a bone substitute for percutaneous transpedicular vertebroplasty. In this study, both G2B1 and commercial PMMA bone cement (CMW1) were implanted into proximal tibiae of rabbits, and their bone-bonding strengths were evaluated at 4, 8, 12 and 16 weeks after implantation. Some of the specimens were evaluated histologically using Giemsa surface staining, contact microradiography (CMR) and scanning electron microscopy (SEM). Histological findings showed that G2B1 contacted bone directly without intervening soft tissue in the specimens at each time point, while there was always a soft tissue layer between CMW1 and bone. The bone-bonding strength of G2B1 was significantly higher than that of CMW1 at each time point, and significantly increased from 4 weeks to 8 and 12 weeks, while it decreased significantly from 12 weeks to 16 weeks. Bone remodeling of the cortex under the cement was observed especially for G2B1 and presumably influenced the bone bonding strength of the cement. The results indicate that G2B1 has bioactivity, and bone bonding strength of bioactive bone cements can be estimated fairly with this experimental model in the short term.
authors.affiliation: Department of Orthopaedic Surgery, Faculty of Medicine, Kyoto University, Kawahara-cho 54, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan. k.g.bau@kuhp.kyoto-u.ac.jp
authors.forename: K
authors.initials: K
authors.lastname: Goto
authors.forename: K
authors.initials: K
authors.lastname: Kawanabe
authors.forename: R
authors.initials: R
authors.lastname: Kowalski
authors.forename: D
authors.initials: D
authors.lastname: Baker
authors.forename: T
authors.initials: T
authors.lastname: Nakamura
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D001843:Bone Cements / Q000737:chemistry* / Q000493:pharmacokinetics*; D018786:Bone Substitutes / Q000737:chemistry; D002484:Cementation; D019544:Equipment Failure Analysis; D008297:Male; D008954:Models, Biological; D009984:Orthopedic Fixation Devices; D016348:Osseointegration / Q000502:physiology; D019904:Polymethyl Methacrylate / Q000737:chemistry / Q000493:pharmacokinetics; D011817:Rabbits; D013499:Surface Properties; D013977:Tibia / Q000378:metabolism* / Q000502:physiology; D013997:Time Factors
chemical_list: D001843:Bone Cements; D018786:Bone Substitutes; D019904:Polymethyl Methacrylate