New markers of neonatal neurology.
Hypoxia-ischemia (H-I) constitutes the main phenomenon responsible for brain-blood barrier permeability modifications leading to cerebral vascular auto-regulation loss in newborns. Hypotension, cerebral ischemia, and reperfusion are the main events involved in vascular auto-regulation loss leading to cell death and tissue damage. Reperfusion could be critical since organ damage, particularly of the brain, may be amplified during this period. An exaggerated activation of vasoactive agents, of calcium mediated effects could be responsible for reperfusion injury (R-I), which, in turns, leads to cerebral hemorrhage and damage. These phenomena represent a common repertoire in newborns complicated by perinatal acute or chronic hypoxia treated by risky procedures such as mechanical ventilation, nitric oxide supplementation, brain cooling, and extracorporeal membrane oxygenation (ECMO). Despite accurate monitoring, the post-insult period is crucial, as clinical symptoms and standard monitoring parameters may be silent at a time when brain damage is already occurring and the therapeutic window for pharmacological intervention is limited. Therefore, the measurement of circulating biochemical markers of brain damage, such as vasoactive agents and nervous tissue peptides is eagerly awaited in clinical practice to detect high risk newborns. The present review is aimed at investigating the role of biochemical markers such as adrenomedullin, a vasoactive peptide; S100B, a calcium binding protein, activin A, a glycoprotein, in the cascade of events leading to I-R injury in newborns complicated by perinatal asphyxia.
Gazzolo
Diego
D
Department of Pediatrics and Neuroscience, G. Gaslini Children's Hospital University of Genoa, Genoa, Italy. dgazzolo@hotmail.com
Abella
Raul
R
Marinoni
Emanuela
E
di Iorio
Romolo
R
Li Volti
Giovanni
G
Galvano
Fabio
F
Frigiola
Alessandro
A
Temporini
Francesca
F
Moresco
Luca
L
Colivicchi
Micaela
M
Sabatini
Miriam
M
Ricotti
Alberto
A
Strozzi
Maria Chiara
MC
Crivelli
Sandro
S
Risso
Francesco Maria
FM
Sannia
Andrea
A
Florio
Pasquale
P
D028341:Activins / Q000097:blood*; D053607:Adrenomedullin / Q000097:blood; D001238:Asphyxia Neonatorum / Q000150:complications; D015415:Biomarkers / Q000097:blood; D001930:Brain Injuries / Q000097:blood* / Q000175:diagnosis / Q000209:etiology; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000097:blood* / Q000209:etiology; D007231:Infant, Newborn; D009414:Nerve Growth Factors / Q000097:blood*; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000097:blood*
D015415:Biomarkers; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; C579160:S100B protein, human; C422405:activin A; D028341:Activins; D053607:Adrenomedullin