title: [Relationship between serum resistin level and large arterial elasticity in patients with essential hypertension].
abstract: OBJECTIVE
  To investigate the association between serum resistin concentration and large arterial elasticity in patients with essential hypertension (EH).
  
  
  METHODS
  271 recruited subjects were divided into the control group (n = 134) and EH group (n = 137). Blood pressure, waist circumference, hip, body mass index (BMI) were measured. Serum resistin concentration was assessed by enzyme immunoassay, fasting serum insulin and TNF-alpha were measured using radioimmunity kits. Insulin resistance was evaluated by insulin resistance index (HOMA-IR). Brachial ankle pulse wave velocity (baPWV) was tested by the full-automatic arteriosclerosis diagnostic instrument.
  
  
  RESULTS
  (1) The serum resistin concentration, baPWV and TNF-alpha were significantly increased in EH group compared to the control group [(0.65 +/- 0.12) ng/ml vs (0.59 +/- 0.13) ng/ml; (1513.24 +/- 182.30) cm/s vs (1301.69 +/- 151.15) cm/s; (5.69 +/- 1.98) ng/ml vs (3.83 +/- 2.38) ng/ml; all P < 0.01]. (2) Pearson correlation analysis showed that resistin was positively correlated with baPWV, TNF-alpha. and HOMA-IR in EH group (r = 0.219, r = 0.212, r = 0.183, P < 0.05 respectively); partial correlation analysis revealed that resistin was positively correlated with baPWV and TNF-alpha (r = 0.238, P < 0.01; r = 0.207, P < 0.05), but not with HOMA-IR. (3) Multivariate regression analysis showed that SBP, age, TNF-alpha, resistin were risk factors of impaired baPWV in EH group (R(2) = 0.368, P < 0.01).
  
  
  CONCLUSIONS
  Large arterial elasticity was decreased in proportion to increasing serum resistin level in hypertensive patients.
authors.affiliation: Department of Cardiology, First Affiliated Hospital, NanJing Medical University, Nanjing 210029, China. xinli3267@yeah.net
authors.forename: Xin-Li
authors.initials: XL
authors.lastname: Li
authors.forename: Qiong
authors.initials: Q
authors.lastname: Xu
authors.forename: Min
authors.initials: M
authors.lastname: Tong
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Zhang
authors.forename: Yan-Li
authors.initials: YL
authors.lastname: Zhou
authors.forename: Jun
authors.initials: J
authors.lastname: Huang
mesh_terms: D001158:Arteries / Q000503:physiopathology*; D001794:Blood Pressure; D004548:Elasticity; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D052243:Resistin / Q000097:blood*; D012737:Sex Factors; D013739:Testosterone / Q000097:blood
chemical_list: D052243:Resistin; D013739:Testosterone