Chiral amidophosphane-rhodium(i)-catalyzed asymmetric conjugate arylation of acyclic enones with arylboronic acids.
A catalytic asymmetric conjugate arylation of acyclic alpha,beta-unsaturated ketones with arylboronic acids was catalyzed by 3 mol% of chiral amidomonophosphane 1-rhodium(I) in the presence of potassium hydroxide in a mixture of 1,4-dioxane and water at 70 degrees C to afford 1,4-conjugate arylated acyclic ketones with high enantiomeric excess in high chemical yield. Thirteen examples of the reaction demonstrate the general applicability of the catalytic system.
Chen
Qian
Q
The Academy of Fundamental and Interdisciplinary Science, Harbin Institute of Technology, China.
Kuriyama
Masami
M
Hao
Xinyu
X
Soeta
Takahiro
T
Yamamoto
Yasutomo
Y
Yamada
Ken-Ichi
K
Tomioka
Kiyoshi
K
D001897:Boronic Acids / Q000737:chemistry; D002384:Catalysis; D007659:Ketones / Q000737:chemistry; D010720:Phosphines / Q000138:chemical synthesis / Q000737:chemistry*; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism
D001897:Boronic Acids; D007659:Ketones; D010720:Phosphines; D012238:Rhodium