A molecular link between AKT regulation and chemotherapeutic response.
The protein kinase AKT is frequently activated in human cancers and has been implicated in resistance to chemotherapy. In this issue of Cancer Cell, Pei et al. show that FKBP51 negatively regulates AKT through the phosphatase PHLPP. This regulation appears to be a determinant of chemosensitivity in cancer cells.
Dibble
Christian C
CC
Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA.
Manning
Brendan D
BD
D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D009687:Nuclear Proteins / Q000378:metabolism*; D010749:Phosphoprotein Phosphatases; D010766:Phosphorylation; D051057:Proto-Oncogene Proteins c-akt / Q000502:physiology*; D012680:Sensitivity and Specificity; D022021:Tacrolimus Binding Proteins / Q000378:metabolism*; D000099159:Tacrolimus Binding Protein 5
D009687:Nuclear Proteins; D010749:Phosphoprotein Phosphatases; D051057:Proto-Oncogene Proteins c-akt; D022021:Tacrolimus Binding Proteins; D000099159:Tacrolimus Binding Protein 5; C400601:PHLPP1 protein, human