[Clinical significance of BMP-2 protein and mRNA expression in human glioma].
OBJECTIVE
To investigate the expression of BMP-2 protein and mRNA in glioma, and evaluate its clinical significance in clinicopathological status of patients with glioma.


METHODS
BMP-2 protein and mRNA expression in 88 patients with glioma were examined by SABC immunohistochemistry and RT-PCR, respectively.


RESULTS
The positive expression rate of BMP-2 protein in glioma tissues were 78.40% (69/88), which was significantly higher (P<0.01) than that in normal brain tissues [3% (6/20)]. The expression of BMP-2 protein and mRNA in gliomas of grade III-IV was also significantly higher than that in gliomas of grade I-II.


CONCLUSIONS
BMP-2 expression in cancerous tissues may play an important role in the progression of glioma, which may help to predict patients' prognosis as a tumor marker.
Zhang
Ming-yu
MY
Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410078, China. hnczmy@163.com
Wu
Jun
J
Gong
Xin
X
Chen
Ruo-kun
RK
Fang
Jia-sheng
JS
D000293:Adolescent; D000328:Adult; D000368:Aged; D055396:Bone Morphogenetic Protein 2 / Q000032:analysis* / Q000235:genetics; D001932:Brain Neoplasms / Q000737:chemistry* / Q000473:pathology; D005910:Glioma / Q000737:chemistry* / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D012333:RNA, Messenger / Q000032:analysis*; D048051:p38 Mitogen-Activated Protein Kinases / Q000502:physiology
C525718:BMP2 protein, human; D055396:Bone Morphogenetic Protein 2; D012333:RNA, Messenger; D048051:p38 Mitogen-Activated Protein Kinases