Two new eudesmane-type sesquiterpenoids from Olanum lyratum.
Two new eudesmane-type sesquiterpenoids, lyratol A-B (1 and 2), were isolated from the whole plant of Olanum lyratum Thunb and their structures were elucidated by extensive spectroscopic analyses. In addition, two new compounds were found to show significant cytotoxicity against selected cancer cells in vitro, including P-388 and HT-29.
Dai
Sheng-Jun
SJ
School of Pharmaceutical Science, Yantai University, People's Republic of China. daishengjun_9@hotmail.com
Shen
Li
L
Ren
Yan
Y
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology; D019073:HT29 Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000737:chemistry* / Q000494:pharmacology*; D045787:Sesquiterpenes, Eudesmane / Q000737:chemistry*; D019657:Solanaceae / Q000737:chemistry*
D000970:Antineoplastic Agents; D004365:Drugs, Chinese Herbal; D012717:Sesquiterpenes; D045787:Sesquiterpenes, Eudesmane; C015872:eudesmane