ATP synthase inhibition of Mycobacterium avium is not bactericidal.
The efficacy of ATP synthase inhibitor TMC207 was assessed in early and late Mycobacterium avium infections in mice. In contrast to what was earlier observed for M. tuberculosis, a bacteriostatic effect was obtained. In vitro, the minimal bactericidal concentration (MBC)/MIC ratio was very high. The MBC was more relevant for assessment of pharmacokinetic/pharmacodynamic relationships than the MIC.
Lounis
Nacer
N
Department of Antimicrobial Research, Tibotec BVBA, Johnson & Johnson, Turnhoutseweg 30, 2340 Beerse, Belgium.
Gevers
Tom
T
Van den Berg
Joke
J
Vranckx
Luc
L
Andries
Koen
K
D000818:Animals; D000995:Antitubercular Agents / Q000494:pharmacology*; D064687:Diarylquinolines; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005260:Female; D051379:Mice; D008810:Mice, Inbred C57BL; D008826:Microbial Sensitivity Tests; D009162:Mycobacterium avium / Q000187:drug effects*; D011804:Quinolines / Q000493:pharmacokinetics / Q000494:pharmacology*
D000995:Antitubercular Agents; D064687:Diarylquinolines; D004791:Enzyme Inhibitors; D011804:Quinolines; C493870:bedaquiline