Kinky binding and SECsy insertions.
Here Budiman et al. (2009) demonstrate that the selective translation of selenocysteine-containing proteins can be regulated by the mutually exclusive binding of eIF4a3 and SECIS binding protein 2 (SBP2) to a cis-acting element in the 3' untranslated region (3'UTR) of the target mRNA.
Morley
Simon J
SJ
Department of Biochemistry, School of Life Sciences, University of Sussex, Brighton BN1 9QG, UK. s.j.morley@sussex.ac.uk
Willett
Mark
M
D020413:3' Untranslated Regions; D000818:Animals; D001665:Binding Sites; D018388:Codon, Terminator; D053487:DEAD-box RNA Helicases / Q000235:genetics / Q000378:metabolism*; D004790:Enzyme Induction; D039601:Eukaryotic Initiation Factor-4A / Q000235:genetics / Q000378:metabolism*; D005979:Glutathione Peroxidase / Q000096:biosynthesis; D006706:Homeostasis; D006801:Humans; D009690:Nucleic Acid Conformation; D000080662:Phospholipid Hydroperoxide Glutathione Peroxidase; D046188:Protein Modification, Translational; D012333:RNA, Messenger / Q000096:biosynthesis / Q000737:chemistry; D016601:RNA-Binding Proteins / Q000378:metabolism*; D051381:Rats; D012643:Selenium / Q000172:deficiency / Q000378:metabolism; D017279:Selenocysteine / Q000378:metabolism; D051140:Selenoproteins / Q000096:biosynthesis* / Q000235:genetics; D000094765:Glutathione Peroxidase GPX1
D020413:3' Untranslated Regions; D018388:Codon, Terminator; D012333:RNA, Messenger; D016601:RNA-Binding Proteins; C498488:Secisbp2 protein, rat; D051140:Selenoproteins; D017279:Selenocysteine; D000080662:Phospholipid Hydroperoxide Glutathione Peroxidase; D005979:Glutathione Peroxidase; D039601:Eukaryotic Initiation Factor-4A; D053487:DEAD-box RNA Helicases; D012643:Selenium; D000094765:Glutathione Peroxidase GPX1