title: Mouse models of diabetic nephropathy.
abstract: Diabetic nephropathy is a major cause of ESRD worldwide. Despite its prevalence, a lack of reliable animal models that mimic human disease has delayed the identification of specific factors that cause or predict diabetic nephropathy. The Animal Models of Diabetic Complications Consortium (AMDCC) was created in 2001 by the National Institutes of Health to develop and characterize models of diabetic nephropathy and other complications. This interim report and our online supplement detail the progress made toward that goal, specifically in the development and testing of murine models. Updates are provided on validation criteria for early and advanced diabetic nephropathy, phenotyping methods, the effect of background strain on nephropathy, current best models of diabetic nephropathy, negative models, and views of future directions. AMDCC investigators and other investigators in the field have yet to validate a complete murine model of human diabetic kidney disease. Nonetheless, the critical analysis of existing murine models substantially enhances our understanding of this disease process.
authors.affiliation: University of Michigan,1150 W. Medical Center Drive, Ann Arbor, MI 48109-0680, USA. fbrosius@umich.edu
authors.forename: Frank C
authors.initials: FC
authors.lastname: Brosius
authors.forename: Charles E
authors.initials: CE
authors.lastname: Alpers
authors.forename: Erwin P
authors.initials: EP
authors.lastname: Bottinger
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Breyer
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Coffman
authors.forename: Susan B
authors.initials: SB
authors.lastname: Gurley
authors.forename: Raymond C
authors.initials: RC
authors.lastname: Harris
authors.forename: Masao
authors.initials: M
authors.lastname: Kakoki
authors.forename: Matthias
authors.initials: M
authors.lastname: Kretzler
authors.forename: Edward H
authors.initials: EH
authors.lastname: Leiter
authors.forename: Moshe
authors.initials: M
authors.lastname: Levi
authors.forename: Richard A
authors.initials: RA
authors.lastname: McIndoe
authors.forename: Kumar
authors.initials: K
authors.lastname: Sharma
authors.forename: Oliver
authors.initials: O
authors.lastname: Smithies
authors.forename: Katalin
authors.initials: K
authors.lastname: Susztak
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Takahashi
authors.forename: Takamune
authors.initials: T
authors.lastname: Takahashi
mesh_terms: D000818:Animals; D058575:Decorin; D003928:Diabetic Nephropathies / Q000209:etiology* / Q000235:genetics / Q000473:pathology; D004195:Disease Models, Animal; D016326:Extracellular Matrix Proteins / Q000172:deficiency; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D052250:Nitric Oxide Synthase Type III / Q000172:deficiency; D010641:Phenotype; D011509:Proteoglycans / Q000172:deficiency; D043782:Receptor, Bradykinin B2 / Q000172:deficiency; D012083:Renin / Q000235:genetics; D013045:Species Specificity
chemical_list: C546878:DCN protein, human; C546879:Dcn protein, mouse; D058575:Decorin; D016326:Extracellular Matrix Proteins; D011509:Proteoglycans; D043782:Receptor, Bradykinin B2; D052250:Nitric Oxide Synthase Type III; C496315:Nos3 protein, mouse; D012083:Renin