title: Aerobic exercise reduced oxidative stress in saliva of persons with Down syndrome.
abstract: The aim of this investigation was to examine the effect of aerobic exercise (AE) on uric acid (UA), total antioxidant activity (TAA), oxidative stress (OS) and nitrite a stable nitric oxide (NO) metabolite in saliva from persons with Down syndrome (DS). Stimulated saliva was sampled from 12 participants 1 hour before and immediately after a 1,600-meter walking test. Uric acid (UA) was assayed by enzymatic method, TAA by ABTS method, lipid hydroperoxides (OS marker) by the ferrous iron/xylenol orange (FOX) method and nitrite concentration by the Griess reaction. Aerobic exercise (AE) caused a decrease in salivary lipid hydroperoxides in persons with DS (p = 0.001). Aerobic exercise (AE), however, did not affect salivary UA, TAA, and nitrite. This result suggested that AE can be considered as a way to reduce the OS in persons with DS, particularly in the mouth cavity.
authors.affiliation: Laboratory of Adaptive Biochemistry, Department of Biochemistry, Faculty of Medicine, Universidad de Los Andes, Merida, Venezuela.
authors.forename: Jean C
authors.initials: JC
authors.lastname: Zambrano
authors.forename: Ramón
authors.initials: R
authors.lastname: Marquina
authors.forename: Nancy
authors.initials: N
authors.lastname: Sulbarán
authors.forename: Antonio J
authors.initials: AJ
authors.lastname: Rodríguez-Malaver
authors.forename: Rafael A
authors.initials: RA
authors.lastname: Reyes
mesh_terms: D000293:Adolescent; D000975:Antioxidants / Q000032:analysis; D004314:Down Syndrome; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D005260:Female; D006801:Humans; D008297:Male; D009569:Nitric Oxide / Q000032:analysis / Q000378:metabolism; D018384:Oxidative Stress / Q000502:physiology*; D012463:Saliva / Q000737:chemistry / Q000378:metabolism; D014527:Uric Acid / Q000032:analysis / Q000378:metabolism; D014687:Venezuela; D055815:Young Adult
chemical_list: D000975:Antioxidants; D014527:Uric Acid; D009569:Nitric Oxide