title: Virulence factor activity relationships for hepatitis E and Cryptosporidium.
abstract: The hepatitis E virus and Cryptosporidium are waterborne pathogens, each consisting of distinct taxa, genotypes and isolates that infect humans, nonhuman animal species or both. Some are associated with disease, others are not. Factors contributing to disease are extremely complicated, possibly involving differences in one or more traits associated with an organism's taxon, genotype or isolate and its infectious dose, and age or condition, as well as the host's physiology and immune status. Potential virulence factors have not yet been identified for HEV. Putative virulence factors for Cryptosporidium might be found in recently recognized genes involved in processes such as excystation, adherence to host cells, invasion, intracellular maintenance and host cell destruction.
authors.affiliation: United States Department of Agriculture, Animal and Natural Resources Institute, Environmental Microbial Safety Laboratory, Beltsville, MD 20705, USA. ronald.fayer@ars.usda.gov
authors.forename: Ronald
authors.initials: R
authors.lastname: Fayer
authors.forename: Palmer
authors.initials: P
authors.lastname: Orlandi
authors.forename: Michael L
authors.initials: ML
authors.lastname: Perdue
mesh_terms: D000818:Animals; D015415:Biomarkers; D003458:Cryptosporidium / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000502:physiology; D005838:Genotype; D016752:Hepatitis E virus / Q000378:metabolism*; D006801:Humans; D037521:Virulence Factors / Q000378:metabolism*; D014871:Water Microbiology
chemical_list: D015415:Biomarkers; D037521:Virulence Factors