[Characteristics of microecological disturbances during endometritis].
OBJECTIVE
To study the state of vaginal microbiocenosis in women with endometritis and to assess association between microecological disturbances and characteristic of clinical course of the disease.


METHODS
Two hundred women of childbearing age with endometritis were studied, of which 83 had acute form of the disease, and 117 - chronic form. Control group was comprised by 30 clinically healthy women. Antilysozyme, anticomplement, and antilactoferrin activities were determined in isolated and identified microorganisms. Microecological disturbances in vaginal biotope were determined applying criteria proposed by Sokolova K.Ya. et al. and Amsel R. et al.


RESULTS
Microecological disturbances in vaginal biotope were revealed on women with endometritis - in particular, bacterial vaginosis, deficiency of dominant microflora (lactobacilli), and the presence of associate microorganisms with clearly expressed persistence characteristics. On the background of microecological disturbances course of endometritis was characterized by high rate of relapses and reduction of remission period.


CONCLUSIONS
Association of endometritis with different types of dysbiotic states of vaginal biotope could be used for prediction of the disease course as well as for correction of microecological disturbances during treatment of endometritis.
Glukhova
E V
EV
Cherkasov
S V
SV
Sgibnev
A V
AV
Bukharin
O V
OV
D000328:Adult; D015169:Colony Count, Microbial; D004716:Endometritis / Q000382:microbiology*; D005260:Female; D006090:Gram-Negative Bacteria / Q000302:isolation & purification* / Q000502:physiology; D006094:Gram-Positive Bacteria / Q000302:isolation & purification* / Q000502:physiology; D006801:Humans; D014621:Vagina / Q000382:microbiology*