title: Principles of design and biological approaches for improving the selectivity of cochlear implant electrodes.
abstract: The perceptual performance of cochlear implant recipients seems to have reached a plateau in recent years. This may be attributable to inadequate neural selectivity of available intracochlear electrodes, caused by current spread and electrode interactions. Attempts to improve electrode selectivity have included manipulating the number and configuration of electrodes that are stimulated at any one time, displacing perilymph from the cochlea to restrict current flow along the cochlea, and reducing the distance between electrodes and neurons. One experimental approach by which the distance between neurons and electrodes may be reduced is to use neurotrophic factors to promote the regeneration of the peripheral dendrites of auditory neurons and guide them towards intracochlear electrodes. The likely requirements of a system for regenerating auditory neurons towards the cochlear electrode include either a stable release of neurotrophin, or transient neurotrophin followed by electrical stimulation; a close proximity of electrode to osseous spiral lamina or a polymer to bridge the gap between the two; guidance signals to attract neurons towards the electrode; patterning of the electrode surface to direct dendrites to electrode contacts and a 'stop' signal to arrest regeneration once the electrode has been reached.
authors.affiliation: Department of Otolaryngology, University of Melbourne, Royal Victorian Eye and Ear Hospital, Australia. sjoleary@unimelb.edu.au
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: O'Leary
authors.forename: Rachael R
authors.initials: RR
authors.lastname: Richardson
authors.forename: Hugh J
authors.initials: HJ
authors.lastname: McDermott
mesh_terms: D000818:Animals; D003054:Cochlear Implants; D004567:Electrodes, Implanted; D004867:Equipment Design; D048091:Guided Tissue Regeneration / Q000295:instrumentation* / Q000379:methods*; D006801:Humans; D012680:Sensitivity and Specificity