title: Electrical impedance tomography and heterogeneity of pulmonary perfusion and ventilation in porcine acute lung injury.
abstract: BACKGROUND
  The heterogeneity of pulmonary ventilation (V), perfusion (Q) and V/Q matching impairs gas exchange in an acute lung injury (ALI). This study investigated the feasibility of electrical impedance tomography (EIT) to assess the V/Q distribution and matching during an endotoxinaemic ALI in pigs.
  
  
  METHODS
  Mechanically ventilated, anaesthetised pigs (n=11, weight 30-36 kg) were studied during an infusion of endotoxin for 150 min. Impedance changes related to ventilation (Z(V)) and perfusion (Z(Q)) were monitored globally and bilaterally in four regions of interest (ROIs) of the EIT image. The distribution and ratio of Z(V) and Z(Q) were assessed. The alveolar-arterial oxygen difference, venous admixture, fractional alveolar dead space and functional residual capacity (FRC) were recorded, together with global and regional lung compliances and haemodynamic parameters. Values are mean+/-standard deviation (SD) and regression coefficients.
  
  
  RESULTS
  Endotoxinaemia increased the heterogeneity of Z(Q) but not Z(V). Lung compliance progressively decreased with a ventral redistribution of Z(V). A concomitant dorsal redistribution of Z(Q) resulted in mismatch of global (from Z(V)/Z(Q) 1.1+/-0.1 to 0.83+/-0.3) and notably dorsal (from Z(V)/Z(Q) 0.86+/-0.4 to 0.51+/-0.3) V and Q. Changes in global Z(V)/Z(Q) correlated with changes in the alveolar-arterial oxygen difference (r(2)=0.65, P<0.05), venous admixture (r(2)=0.66, P<0.05) and fractional alveolar dead space (r(2)=0.61, P<0.05). Decreased end-expiratory Z(V) correlated with decreased FRC (r(2)=0.74, P<0.05).
  
  
  CONCLUSIONS
  EIT can be used to assess the heterogeneity of regional pulmonary ventilation and perfusion and V/Q matching during endotoxinaemic ALI, identifying pivotal pathophysiological changes.
authors.affiliation: Department of Anaesthesiology and Intensive Care, Sahlgrenska University Hospital, Blå Stråket 5, Gothenburg, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Fagerberg
authors.forename: S
authors.initials: S
authors.lastname: Söndergaard
authors.forename: S
authors.initials: S
authors.lastname: Karason
authors.forename: A
authors.initials: A
authors.lastname: Aneman
mesh_terms: D055371:Acute Lung Injury / Q000175:diagnosis* / Q000503:physiopathology*; D000818:Animals; D004195:Disease Models, Animal; D017097:Electric Impedance; D019446:Endotoxemia / Q000503:physiopathology; D006439:Hemodynamics / Q000502:physiology; D008170:Lung Compliance / Q000502:physiology; D016017:Odds Ratio; D012123:Pulmonary Ventilation / Q000502:physiology*; D012129:Respiratory Function Tests; D013552:Swine; D014054:Tomography / Q000379:methods*; D016896:Treatment Outcome; D014692:Ventilation-Perfusion Ratio / Q000502:physiology*