title: Successful treatment of bacillary hemoglobinuria in Japanese Black cows.
abstract: Four pasture-fed Japanese Black cows showed the main clinical symptoms of severe hemoglobinuria at different periods between 2003 and 2007. Hematological analyses at the first consultation revealed severe anemia, and biochemical analyses indicated both severe hemolysis and disruption of hepatic function. Although the first 2 patients died, the hemoglobinuria and general condition of the remaining 2 cows, who were immediately initiated on large doses of antibiotics, improved within 3 days. Clostridium haemolyticum was detected by polymerase chain reaction (PCR) analysis of the blood sample of 1 of the infected cows. Anti-fascioliasis medicine is administered, and since then, no case of hemoglobinuria has been observed. The cows were diagnosed with bacillary hemoglobinuria, and they represent the first few cases in Japan.
authors.affiliation: Laboratory of Farm Animal Production Medicine, Kagoshima University, Kagoshima, Japan. mtakagi@agri.kagoshima-u.ac.jp
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Takagi
authors.forename: Osamu
authors.initials: O
authors.lastname: Yamato
authors.forename: Yoshimasa
authors.initials: Y
authors.lastname: Sasaki
authors.forename: Shuhei
authors.initials: S
authors.lastname: Mukai
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Fushimi
authors.forename: Takashi
authors.initials: T
authors.lastname: Yoshida
authors.forename: Keijiro
authors.initials: K
authors.lastname: Mizukami
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Shoubudani
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Amimoto
authors.forename: Takehisa
authors.initials: T
authors.lastname: Chuma
authors.forename: Francis
authors.initials: F
authors.lastname: Shahada
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Endo
authors.forename: Eisaburo
authors.initials: E
authors.lastname: Deguchi
mesh_terms: D000667:Ampicillin / Q000627:therapeutic use; D000740:Anemia / Q000382:microbiology / Q000662:veterinary; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001066:Appetite; D001424:Bacterial Infections / Q000188:drug therapy / Q000382:microbiology / Q000662:veterinary*; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy / Q000382:microbiology*; D002437:Cefazolin / Q000627:therapeutic use; D003013:Clostridium / Q000235:genetics / Q000302:isolation & purification; D003015:Clostridium Infections / Q000188:drug therapy / Q000662:veterinary*; D004359:Drug Therapy, Combination; D005260:Female; D006456:Hemoglobinuria / Q000188:drug therapy / Q000382:microbiology* / Q000662:veterinary*; D016133:Polymerase Chain Reaction; D012417:Rumen / Q000502:physiology; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D000667:Ampicillin; D002437:Cefazolin