title: Tandem Chain Extension-Iodomethylation Reactions: Formation of alpha-Functionalized gamma-Keto Carbonyls.
abstract: Sequential exposure of a zinc-organometallic intermediate, generated through a zinc carbenoid-mediated chain extension reaction of a beta-keto carbonyl, to trimethylsilylchloride and iodine provided regioselective formation of an alpha-iodomethyl-gamma-keto carbonyl. The iodomethyl functionality can be further manipulated to provide side chains that are potential mimics of alpha-amino acid side chains.
authors.affiliation: Department of Chemistry, University of New Hampshire, Durham, NH 03824.
authors.forename: Qinglin
authors.initials: Q
authors.lastname: Pu
authors.forename: Emerald
authors.initials: E
authors.lastname: Wilson
authors.forename: Charles K
authors.initials: CK
authors.lastname: Zercher