title: Pharmacokinetics of moxifloxacin in cerebrospinal fluid and plasma in patients with tuberculous meningitis.
abstract: Moxifloxacin cerebrospinal fluid (CSF) penetration was evaluated by obtaining full plasma and CSF time concentration curves for 4 patients with tuberculous meningitis. The geometric mean ratio of the areas under the curve for CSF to plasma were 0.82 (range, 0.70-0.94) at 400 mg once per day and 0.71 (0.58-0.84) at 800 mg once per day.
authors.affiliation: Department of Hospital and Clinical Pharmacy, University Medical Center Groningen, PO Box 30.001, 9700 RB Groningen, the Netherlands. j.w.c.alffenaar@apoth.umcg.nl
authors.forename: J W C
authors.initials: JW
authors.lastname: Alffenaar
authors.forename: R
authors.initials: R
authors.lastname: van Altena
authors.forename: H J
authors.initials: HJ
authors.lastname: Bökkerink
authors.forename: G J
authors.initials: GJ
authors.lastname: Luijckx
authors.forename: D
authors.initials: D
authors.lastname: van Soolingen
authors.forename: R E
authors.initials: RE
authors.lastname: Aarnoutse
authors.forename: T S
authors.initials: TS
authors.lastname: van der Werf
mesh_terms: D000328:Adult; D000368:Aged; D000995:Antitubercular Agents / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D019540:Area Under Curve; D001372:Aza Compounds / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D002555:Cerebrospinal Fluid / Q000737:chemistry*; D024841:Fluoroquinolones; D006801:Humans; D008297:Male; D008875:Middle Aged; D000077266:Moxifloxacin; D010949:Plasma / Q000737:chemistry*; D011804:Quinolines / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D013997:Time Factors; D014390:Tuberculosis, Meningeal / Q000188:drug therapy*
chemical_list: D000995:Antitubercular Agents; D001372:Aza Compounds; D024841:Fluoroquinolones; D011804:Quinolines; D000077266:Moxifloxacin