Successful treatment of bacillary hemoglobinuria in Japanese Black cows.
Four pasture-fed Japanese Black cows showed the main clinical symptoms of severe hemoglobinuria at different periods between 2003 and 2007. Hematological analyses at the first consultation revealed severe anemia, and biochemical analyses indicated both severe hemolysis and disruption of hepatic function. Although the first 2 patients died, the hemoglobinuria and general condition of the remaining 2 cows, who were immediately initiated on large doses of antibiotics, improved within 3 days. Clostridium haemolyticum was detected by polymerase chain reaction (PCR) analysis of the blood sample of 1 of the infected cows. Anti-fascioliasis medicine is administered, and since then, no case of hemoglobinuria has been observed. The cows were diagnosed with bacillary hemoglobinuria, and they represent the first few cases in Japan.
Takagi
Mitsuhiro
M
Laboratory of Farm Animal Production Medicine, Kagoshima University, Kagoshima, Japan. mtakagi@agri.kagoshima-u.ac.jp
Yamato
Osamu
O
Sasaki
Yoshimasa
Y
Mukai
Shuhei
S
Fushimi
Yasuo
Y
Yoshida
Takashi
T
Mizukami
Keijiro
K
Shoubudani
Tomoaki
T
Amimoto
Katsuhiko
K
Chuma
Takehisa
T
Shahada
Francis
F
Endo
Yasuyuki
Y
Deguchi
Eisaburo
E
D000667:Ampicillin / Q000627:therapeutic use; D000740:Anemia / Q000382:microbiology / Q000662:veterinary; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001066:Appetite; D001424:Bacterial Infections / Q000188:drug therapy / Q000382:microbiology / Q000662:veterinary*; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy / Q000382:microbiology*; D002437:Cefazolin / Q000627:therapeutic use; D003013:Clostridium / Q000235:genetics / Q000302:isolation & purification; D003015:Clostridium Infections / Q000188:drug therapy / Q000662:veterinary*; D004359:Drug Therapy, Combination; D005260:Female; D006456:Hemoglobinuria / Q000188:drug therapy / Q000382:microbiology* / Q000662:veterinary*; D016133:Polymerase Chain Reaction; D012417:Rumen / Q000502:physiology; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D000667:Ampicillin; D002437:Cefazolin