Bile acids have the gall to function as hormones.
In this issue of Cell Metabolism, Thomas et al. (2009) show that specific activation of the bile-acid-activated G protein-coupled receptor TGR5 improves pancreatic and hepatic function and impairs the development of obesity following administration of a high-fat diet.
Vallim
Thomas Quad de Aguiar
TQ
Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, BSRB Room 310, Los Angeles, CA 90095, USA.
Edwards
Peter A
PA
D000818:Animals; D001647:Bile Acids and Salts / Q000378:metabolism*; D019858:Enteroendocrine Cells / Q000378:metabolism; D052216:Glucagon-Like Peptide 1 / Q000172:deficiency / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D007328:Insulin / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D043562:Receptors, G-Protein-Coupled / Q000819:agonists / Q000172:deficiency / Q000378:metabolism*; D015398:Signal Transduction
D001647:Bile Acids and Salts; C513561:Gpbar1 protein, mouse; D007328:Insulin; D043562:Receptors, G-Protein-Coupled; D052216:Glucagon-Like Peptide 1; D005947:Glucose