title: [Clinical and epidemiological features of Burkitt's lymphoma].
abstract: OBJECTIVE
  To characterize clinical and epidemiological features of adult Berkitt's lymphoma (BL).
  
  
  METHODS
  The trial enrolled 72 patients (51 males and 21 females, age 14-69, mean age 27 years) treated in 1995-2008.
  
  
  RESULTS
  Stage I BL (by S.B. Murphy) was diagnosed in 5 patients, stage II--in 9, stage III--in 25, IV--in 14 patients, B-cell acute lymphoblastic leukemia (ALL) (L3)--in 19 patients. Intoxication was seen in 56 (78%) patients, 38% patients had severe cachexia. Elevated concentration of lactatedehydrogenase (LDG) was detected in 57 (79%) patients. In all the cases clinical symptoms developed for 1-3 months, median 6 weeks. Bone marrow involvement was diagnosed in 22 (31%) patients, CNS was affected in 17 (24%) patients, of them 14 were males. Fifty two (72%) patients had abdominal, retroperitoneal and/or small pelvis tumors. Intestinal, hepatic, renal and gastric tumors occurred most frequently. Specific ascitis was detected in 25 (48%), tumor pleuritis--in 11 (15%) patients. BL of the facial skeleton, Waldeyer's ring, oro- and nasopharynx was in 12 (17%) patients. Seven patients had concomitant involvement of the CNS. Eight (38%) and 2 (10%) women had tumors of the ovaries and uterus, respectively.
  
  
  CONCLUSIONS
  BL is characterized by the following clinical features: young age of the patients, most of them are males, B-symptoms, short history, generalized stages, extranodal lesions, firequent involvement of the bone marrow and CNS.
authors.forename: E A
authors.initials: EA
authors.lastname: Bariakh
authors.forename: S K
authors.initials: SK
authors.lastname: Kravchenko
authors.forename: A M
authors.initials: AM
authors.lastname: Kremenetskaia
authors.forename: E E
authors.initials: EE
authors.lastname: Zvonkov
authors.forename: T N
authors.initials: TN
authors.lastname: Obukhova
authors.forename: A U
authors.initials: AU
authors.lastname: Magomedova
authors.forename: A I
authors.initials: AI
authors.lastname: Vorob'ev
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002051:Burkitt Lymphoma / Q000150:complications / Q000175:diagnosis* / Q000201:enzymology / Q000453:epidemiology* / Q000473:pathology; D005260:Female; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012737:Sex Factors; D055815:Young Adult
chemical_list: D007770:L-Lactate Dehydrogenase