Synthesis and anticancer activity of novel 3,4-diarylthiazol-2(3H)-ones (imines).
A series of 3,4-diarylthiazol-2(3H)-ones and three 3,4-diarylthiazol-2(3H)-imines were synthesized and evaluated for their cytotoxicity in a panel of human cancer cell lines. Compounds 21 and 22 showed potential anticancer activity against human CEM cells with IC50 values of 0.12 and 0.24microM, respectively.
Liu
Zong-Ying
ZY
Department of Chemistry, Georgia State University, Atlanta, GA 30303-3083, USA.
Wang
Yue-Ming
YM
Li
Zhuo-Rong
ZR
Jiang
Jian-Dong
JD
Boykin
David W
DW
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007097:Imines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013844:Thiazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity
D000970:Antineoplastic Agents; D007097:Imines; D013844:Thiazoles