title: Stress-induced changes of interleukin-1beta within the limbic system in the rat.
abstract: The aim of this study was to investigate the influence of two periods of life, namely P28 and P360, on the changes in interleukin-1beta (IL-1beta) immunoreactivity (-ir) in the hippocampus (CA1, CA3, DG) and amygdala (central-CeA, medial-MeA) caused by acute and repeated open field (OF), or by forced swim (FS) exposition. Rats were divided into groups: non-stressed, exposed to acute (one-time for 15 min) and chronic stressors (21 days for 15 min daily). We found IL-1beta-ir in the control group to be higher in P360 than in P28. In P28, under OF and FS exposure, IL-1beta-ir in the CeA remained unaltered but increased in the MeA and in the hippocampus after acute and chronic stress. In P360 no changes were observed in the IL-1beta-ir level after acute and chronic stimulation. These data demonstrate that only the levels of IL-1beta-ir in juvenile rat brains are affected by FS and OF. Additionally, there was no significant difference between FS and OF stimulation in IL-1beta-ir.
authors.affiliation: Deaprtment of Anatomy and Neurobiology, Medical University of Gdańsk, Poland. ewabadowska@amg-gda.pl
authors.forename: E
authors.initials: E
authors.lastname: Badowska-Szalewska
authors.forename: I
authors.initials: I
authors.lastname: Klejbor
authors.forename: J
authors.initials: J
authors.lastname: Sidor-Kaczmarek
authors.forename: T
authors.initials: T
authors.lastname: Cecot
authors.forename: G
authors.initials: G
authors.lastname: Lietzau
authors.forename: J H
authors.initials: JH
authors.lastname: Spodnik
authors.forename: J
authors.initials: J
authors.lastname: Moryś
mesh_terms: D000367:Age Factors; D000375:Aging / Q000276:immunology / Q000378:metabolism; D000679:Amygdala / Q000276:immunology / Q000378:metabolism / Q000503:physiopathology; D000818:Animals; D001931:Brain Mapping; D002908:Chronic Disease; D005455:Fluorescent Antibody Technique; D006624:Hippocampus / Q000276:immunology / Q000378:metabolism / Q000503:physiopathology; D053583:Interleukin-1beta / Q000378:metabolism*; D008032:Limbic System / Q000276:immunology / Q000378:metabolism* / Q000503:physiopathology; D008297:Male; D015213:Neuroimmunomodulation / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D013315:Stress, Psychological / Q000276:immunology / Q000378:metabolism* / Q000503:physiopathology; D013550:Swimming / Q000523:psychology; D015854:Up-Regulation / Q000502:physiology
chemical_list: D053583:Interleukin-1beta