Hear the Wnt Ror: how melanoma cells adjust to changes in Wnt.
The interplay between canonical and non-canonical Wnt pathways in development and tumorigenesis is tightly regulated. In this review we will describe the yin and the yang of canonical and non-canonical Wnt signaling pathways during melanocyte development, and melanoma genesis. Canonical Wnt signaling, represented by Wnts such as Wnt1 and Wnt3A, signals via beta-catenin to promote melanocyte differentiation and tumor development. Non-canonical Wnt signaling, specifically Wnt5A, regulates canonical pathways, and signals to induce melanoma metastasis. This review will focus on the role of Wnt5A during melanoma progression, and its relationship to canonical Wnt signaling.
O'Connell
Michael P
MP
Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore MD, USA.
Weeraratna
Ashani T
AT
D002454:Cell Differentiation / Q000502:physiology; D003599:Cytoskeleton / Q000378:metabolism; D018450:Disease Progression; D051157:Frizzled Receptors / Q000235:genetics / Q000378:metabolism; D008544:Melanocytes / Q000166:cytology / Q000502:physiology; D008545:Melanoma / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D009362:Neoplasm Metastasis; D010858:Pigmentation / Q000502:physiology; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000378:metabolism; D057050:Receptor Tyrosine Kinase-like Orphan Receptors / Q000235:genetics / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D013234:Stem Cells / Q000502:physiology; D051153:Wnt Proteins / Q000235:genetics / Q000378:metabolism*; D000071818:Wnt-5a Protein; D051176:beta Catenin / Q000378:metabolism
D051157:Frizzled Receptors; D011518:Proto-Oncogene Proteins; D043562:Receptors, G-Protein-Coupled; C085389:WNT5A protein, human; D051153:Wnt Proteins; D000071818:Wnt-5a Protein; D051176:beta Catenin; D057050:Receptor Tyrosine Kinase-like Orphan Receptors