Consumption of some polyphenols reduces fecal deoxycholic acid and lithocholic acid, the secondary bile acids of risk factors of colon cancer.
This study was performed to examine the effect of dietary polyphenols on fecal secondary bile acids, such as deoxycholic acid and lithocholic acid, the risk factors of colon cancer, in rats fed a high-fat diet. In experiment 1, rats were fed a 30% beef tallow diet containing 0.5% polyphenols for 3 weeks. Dietary curcumin and caffeic acid significantly reduced the fecal concentration of deoxycholic acid. Dietary caffeic acid, catechin, rutin, and ellagic acid significantly reduced fecal lithocholic acid. Fecal hyodeoxycholic acid, a metabolite of lithocholic acid, was markedly lowered by dietary curcumin, caffeic acid, catechin, and rutin. In experiment 2, rats were fed a 30 or 5% beef tallow diet with or without the addition of 0.5% curcumin. In the rats without receiving curcumin, the fecal level of deoxycholic acid was significantly higher in the high-fat diet group than in the low-fat diet group. Fecal deoxycholic acid was significantly reduced by dietary curcumin in the high-fat diets but not in the low-fat diets. The results suggest novel effects of some polyphenols favorable for colon health by reducing secondary bile acids in animals fed a high-fat diet.
Han
Yunkyung
Y
Graduate School of Biosphere Science, Hiroshima University, Higashi-Hiroshima 739-8528, Japan.
Haraguchi
Tomoaki
T
Iwanaga
Sumie
S
Tomotake
Hiroyuki
H
Okazaki
Yukako
Y
Mineo
Shigeru
S
Moriyama
Akiho
A
Inoue
Junji
J
Kato
Norihisa
N
D000818:Animals; D016588:Anticarcinogenic Agents / Q000008:administration & dosage; D002109:Caffeic Acids / Q000008:administration & dosage; D003110:Colonic Neoplasms / Q000209:etiology / Q000517:prevention & control*; D003474:Curcumin / Q000008:administration & dosage; D003840:Deoxycholic Acid / Q000032:analysis*; D004032:Diet; D004041:Dietary Fats / Q000008:administration & dosage; D005243:Feces / Q000737:chemistry*; D005419:Flavonoids / Q000008:administration & dosage*; D008095:Lithocholic Acid / Q000032:analysis*; D008297:Male; D010636:Phenols / Q000008:administration & dosage*; D059808:Polyphenols; D051381:Rats; D017207:Rats, Sprague-Dawley; D012307:Risk Factors
D016588:Anticarcinogenic Agents; D002109:Caffeic Acids; D004041:Dietary Fats; D005419:Flavonoids; D010636:Phenols; D059808:Polyphenols; D003840:Deoxycholic Acid; D008095:Lithocholic Acid; D003474:Curcumin; C040048:caffeic acid