Dual drug delivery microcapsules via layer-by-layer self-assembly.
The integration of hydrophobic and hydrophilic drugs in the polymer microcapsule offers the possibility of developing a new drug delivery system that combines the best features of these two distinct classes of material. Recently, we have reported the encapsulation of an uncharged water-insoluble drug in the polymer membrane. The hydrophobic drug is deposited using a layer-by-layer (LbL) technique, which is based on the sequential adsorption of oppositely charged polyelectrolytes onto a charged substrate. In this paper, we report the encapsulation of two different drugs, which are invariably different in structure and in their solubility in water. We have characterized these dual drug vehicular capsules by confocal laser scanning microscopy, atomic force microscopy, visible microscopy, and transmission electron microscopy. The growth of a thin film on a flat substrate by LbL was monitored by UV-vis spectra. The desorption kinetics of two drugs from the thin film was modeled by a second-order rate model.
Manna
Uttam
U
Solid State and Structural Chemistry Unit Indian Institute of Science, Bangalore-560012, India.
Patil
Satish
S
D002214:Capsules; D048271:Chitosan / Q000737:chemistry; D016503:Drug Delivery Systems; D004548:Elasticity; D004573:Electrolytes / Q000737:chemistry; D031541:Fluorescence Resonance Energy Transfer; D057927:Hydrophobic and Hydrophilic Interactions; D007700:Kinetics; D008751:Methylene Blue; D008823:Micelles; D008853:Microscopy; D010569:Perylene / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D011721:Pyrenes / Q000737:chemistry; D012235:Rhodamines; D012967:Sodium Dodecyl Sulfate; D012995:Solubility; D013053:Spectrophotometry
D002214:Capsules; D004573:Electrolytes; D008823:Micelles; D011108:Polymers; D011721:Pyrenes; D012235:Rhodamines; D012967:Sodium Dodecyl Sulfate; D010569:Perylene; D048271:Chitosan; C030984:pyrene; C029773:rhodamine B; D008751:Methylene Blue