Unexpected preferential dehydration of artemisinin in ionic liquids.
Thermodynamic measurements (at 298 K) reveal that a crucial step in the extraction process of the key antimalarial drug artemisinin by ionic liquids (ILs), namely, precipitation through the addition of water, is driven by artemisinin dehydration due to the differences in the water's interaction with the bulk ILs, rather than with the artemisinin itself.
Sanders
Marc W
MW
Wright
Lawrence
L
Tate
Lauren
L
Fairless
Gayle
G
Crowhurst
Lorna
L
Bruce
Neil C
NC
Walker
Adam J
AJ
Hembury
Guy A
GA
Shimizu
Seishi
S
D037621:Artemisinins / Q000737:chemistry*; D003681:Dehydration; D052578:Ionic Liquids / Q000737:chemistry*; D013816:Thermodynamics; D014867:Water / Q000737:chemistry
D037621:Artemisinins; D052578:Ionic Liquids; D014867:Water; C031327:artemisinin