Determination of treatment strategies for granular corneal dystrophy type 2 using Fourier-domain optical coherence tomography.
OBJECTIVE
To evaluate the use of Fourier-domain optical coherence tomography (FD-OCT) in the selection and planning of surgical procedures to treat GCD2 (granular corneal dystrophy type 2).


METHODS
An RTVue-100 FD-OCT (Optovue, Fremont, California) was used to determine the size, depth and location of deposits in six patients with homozygous or heterozygous GCD2.


RESULTS
The RTVue-100 FD-OCT revealed the depth of the deposits quite precisely, allowing the determination of the appropriate depth of PTK (phototherapeutic keratectomy) and the appropriate selection of lamellar versus penetrating keratoplasty as the procedure of choice. In each case, visually significant opacities were adequately removed or would be removed.


CONCLUSIONS
FD-OCT provides useful information for the selection and planning of surgical procedures to remove corneal opacities in patients with GCD2.
Kim
Tae-im
TI
Department of Ophthalmology, Corneal Dystrophy Research Institute, Yonsei University, College of Medicine, Seoul, Korea.
Hong
Jin Pyo
JP
Ha
Byung Jin
BJ
Stulting
R Doyle
RD
Kim
Eung Kweon
EK
D000328:Adult; D000368:Aged; D003317:Corneal Dystrophies, Hereditary / Q000150:complications / Q000235:genetics / Q000473:pathology* / Q000601:surgery*; D003318:Corneal Opacity / Q000209:etiology / Q000473:pathology / Q000601:surgery; D016039:Corneal Transplantation / Q000379:methods; D005260:Female; D005583:Fourier Analysis; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D054018:Lasers, Excimer / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D018903:Photorefractive Keratectomy; D012008:Recurrence; D012086:Reoperation / Q000379:methods; D041623:Tomography, Optical Coherence / Q000379:methods; D016896:Treatment Outcome