Gold nanoparticles functionalized with gadolinium chelates as high-relaxivity MRI contrast agents.
Water-dispersible gold nanoparticles functionalized with paramagnetic gadolinium have been fully characterized, and the NMRD profiles show very high relaxivities up to 1.5 T. Characterization using TEM images and dynamic light scattering indicate a particle size distribution from 2 to 15 nm. The gold cores of the nanoparticles do not contribute significantly to the overall magnetic moment.
Moriggi
Loïck
L
Institut des Sciences et Ingénieurie Chimique, Ecole Polytechnique Fédérale de Lausanne, CH 1015 Lausanne, Switzerland.
Cannizzo
Caroline
C
Dumas
Eddy
E
Mayer
Cédric R
CR
Ulianov
Alexey
A
Helm
Lothar
L
D003287:Contrast Media / Q000737:chemistry*; D005682:Gadolinium / Q000737:chemistry*; D006046:Gold; D008279:Magnetic Resonance Imaging / Q000379:methods*; D053768:Metal Nanoparticles / Q000737:chemistry; D010316:Particle Size
D003287:Contrast Media; D006046:Gold; D005682:Gadolinium