Unraveling the secrets of regulating mitochondrial DNA replication.
In this issue, Liu et al. (2009) report that maxicircle DNA copy number in trypanosomes is regulated by proteolysis of a helicase; the complex kinetoplast DNA system yields a clear view of how mitochondrial DNA replication can be regulated.
Klingbeil
Michele M
MM
Department of Microbiology, University of Massachusetts, Amherst, MA 01003, USA. klingbeil@microbio.umass.edu
Shapiro
Theresa A
TA
D000818:Animals; D004265:DNA Helicases / Q000235:genetics / Q000378:metabolism*; D004261:DNA Replication; D018105:DNA, Kinetoplast / Q000096:biosynthesis*; D004272:DNA, Mitochondrial / Q000096:biosynthesis*; D016054:DNA, Protozoan / Q000096:biosynthesis*; D005786:Gene Expression Regulation; D009154:Mutation; D010447:Peptide Hydrolases / Q000378:metabolism; D015800:Protozoan Proteins / Q000235:genetics / Q000378:metabolism*; D013997:Time Factors; D014346:Trypanosoma brucei brucei / Q000201:enzymology / Q000235:genetics* / Q000254:growth & development
D018105:DNA, Kinetoplast; D004272:DNA, Mitochondrial; D016054:DNA, Protozoan; D015800:Protozoan Proteins; D010447:Peptide Hydrolases; D004265:DNA Helicases