title: [Portal vein thrombosis].
abstract: Thrombosis of the splenoportal axis not associated with liver cirrhosis or tumoral disease is the second cause of portal hypertension in the western world. In up to 60% of cases, an underlying systemic prothrombotic disorder can be identified as an etiological factor. One third of cases are caused by local factors and the coexistence of several entities is not unusual. Therefore, an etiologic diagnosis is essential in these patients. Early anticoagulation therapy in the acute phase of thrombosis of the splenoportal axis significantly affects the probability of recanalization and consequently the prognosis of these patients. In the chronic phase of splenoportal thrombosis (or portal cavernoma), the symptoms are caused by the complications of established portal hypertension. To date, anticoagulation therapy is limited to patients in whom an underlying prothrombotic disorder has been demonstrated.
authors.affiliation: Laboratorio de Hemodinámica Hepática, Servicio de Hepatología, Institut de Malalties Digestives I Metaboliques, Hospital Clinic, IDIBAPS, CIBERehd, Barcelona, España.
authors.forename: Susana
authors.initials: S
authors.lastname: Seijo-Ríos
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: García-Pagán
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003278:Contraceptives, Oral, Hormonal / Q000009:adverse effects; D003952:Diagnostic Imaging / Q000379:methods; D004932:Esophageal and Gastric Varices / Q000209:etiology; D005260:Female; D005705:Gallbladder Diseases / Q000209:etiology / Q000628:therapy; D006471:Gastrointestinal Hemorrhage / Q000209:etiology; D006801:Humans; D006975:Hypertension, Portal / Q000209:etiology; D008026:Ligation; D008103:Liver Cirrhosis / Q000150:complications; D008297:Male; D009196:Myeloproliferative Disorders / Q000150:complications / Q000235:genetics; D009369:Neoplasms / Q000150:complications; D011169:Portal Vein; D011183:Postoperative Complications; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000628:therapy; D015995:Prevalence; D019851:Thrombophilia / Q000150:complications / Q000235:genetics; D014662:Vasoconstrictor Agents / Q000627:therapeutic use; D020246:Venous Thrombosis / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000601:surgery
chemical_list: D000925:Anticoagulants; D003278:Contraceptives, Oral, Hormonal; D014662:Vasoconstrictor Agents