title: Automated production of copper radioisotopes and preparation of high specific activity [(64)Cu]Cu-ATSM for PET studies.
abstract: (60)Cu and (64)Cu are useful radioisotopes for positron emission tomography (PET) radiopharmaceuticals and may be used for the preparation of promising agents for diagnosis and radiotherapy. In this study, the production and purification of (60/64)Cu starting from (60/64)Ni using a new automated system, namely Alceo, is described. A dynamic process for electrodeposition and dissolution of (60/64)Ni/(60/64)Cu was developed. Preliminary production yields of (60)Cu and (64)Cu were 400 and 300mCi, respectively. (64)Cu was used to radiolabel the hypoxia detection tracer ATSM with a specific activity of 2.2+/-1.3Ci/micromol.
authors.affiliation: Institute of Molecular Bioimaging and Physiology-CNR, University of Milano-Bicocca, San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milano, Italy. matarrese.mario@hsr.it
authors.forename: Mario
authors.initials: M
authors.lastname: Matarrese
authors.forename: Paolo
authors.initials: P
authors.lastname: Bedeschi
authors.forename: Roberto
authors.initials: R
authors.lastname: Scardaoni
authors.forename: Francesco
authors.initials: F
authors.lastname: Sudati
authors.forename: Annarita
authors.initials: A
authors.lastname: Savi
authors.forename: Annalisa
authors.initials: A
authors.lastname: Pepe
authors.forename: Valeria
authors.initials: V
authors.lastname: Masiello
authors.forename: Sergio
authors.initials: S
authors.lastname: Todde
authors.forename: Luigi
authors.initials: L
authors.lastname: Gianolli
authors.forename: Cristina
authors.initials: C
authors.lastname: Messa
authors.forename: Ferruccio
authors.initials: F
authors.lastname: Fazio
mesh_terms: D001331:Automation / Q000295:instrumentation; D056831:Coordination Complexes; D003301:Copper Radioisotopes / Q000737:chemistry*; D017357:Cyclotrons; D007554:Isotopes / Q000737:chemistry; D009532:Nickel / Q000737:chemistry; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000302:isolation & purification; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*; D013882:Thiosemicarbazones / Q000138:chemical synthesis* / Q000302:isolation & purification
chemical_list: D056831:Coordination Complexes; D003301:Copper Radioisotopes; D007554:Isotopes; D009942:Organometallic Compounds; D019275:Radiopharmaceuticals; D013882:Thiosemicarbazones; C089548:copper (II) diacetyl-di(N(4)-methylthiosemicarbazone); D009532:Nickel