title: Rheumatoid arthritis does not share most of the newly identified systemic lupus erythematosus genetic factors.
abstract: OBJECTIVE
  Rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) share some genetic factors such as HLA, PTPN22, STAT4, and 6q23. The aim of this study was to determine whether 9 other SLE genetic factors are also implicated in RA susceptibility.
  
  
  METHODS
  A characteristic single-nucleotide polymorphism (SNP) in each of 9 genetic factors, ITGAM (rs1143679), C8orf13-BLK (rs13277113), TYK2 (rs2304256), 1q25.1 (rs10798269), PXK (rs6445975), KIAA1542 (rs4963128), MECP2 (rs17435), BANK1 (rs17266594), and LY9 (rs509749), was studied in 1,635 patients with RA and 1,906 control subjects from Spain. The rs7574865 SNP in STAT4 was also included. Analyses were conducted globally and after stratification by sex and clinical features (anti-cyclic citrullinated peptide and rheumatoid factor, shared epitope, rheumatoid nodules, radiographic changes, sicca syndrome, and pneumonitis).
  
  
  RESULTS
  No association was observed between RA and any of the 9 newly identified SLE genetic factors. A meta-analysis using previous data was consistent with these results. In addition, there were no significant differences between individuals with and those without each of the clinical features analyzed, except the frequency of the minor allele in the C8orf13-BLK locus that was decreased in patients with sicca syndrome (14.6% versus 22.4% in controls; P = 0.003).
  
  
  CONCLUSIONS
  None of the 9 recently identified SLE risk factors showed association with RA. Therefore, common genetic factors affecting the pathogenesis of these 2 disorders seem to be limited, revealing that the genetic component contributes to the different expression of these diseases.
authors.affiliation: Hospital Clinico Universitario de Santiago, Travesia de Choupana s/n, Santiago de Compostela, Spain.
authors.forename: Marian
authors.initials: M
authors.lastname: Suarez-Gestal
authors.forename: Manuel
authors.initials: M
authors.lastname: Calaza
authors.forename: Rebeca
authors.initials: R
authors.lastname: Dieguez-Gonzalez
authors.forename: Eva
authors.initials: E
authors.lastname: Perez-Pampin
authors.forename: Jose Luis
authors.initials: JL
authors.lastname: Pablos
authors.forename: Federico
authors.initials: F
authors.lastname: Navarro
authors.forename: Javier
authors.initials: J
authors.lastname: Narvaez
authors.forename: Jose Luis
authors.initials: JL
authors.lastname: Marenco
authors.forename: Gabriel
authors.initials: G
authors.lastname: Herrero-Beaumont
authors.forename: Benjamin
authors.initials: B
authors.lastname: Fernandez-Gutierrez
authors.forename: Jose Ramon
authors.initials: JR
authors.lastname: Lamas
authors.forename: Arturo Rodriguez
authors.initials: AR
authors.lastname: de la Serna
authors.forename: Ana Maria
authors.initials: AM
authors.lastname: Ortiz
authors.forename: Luis
authors.initials: L
authors.lastname: Carreño
authors.forename: Juan D
authors.initials: JD
authors.lastname: Cañete
authors.forename: Rafael
authors.initials: R
authors.lastname: Caliz
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Blanco
authors.forename: Alejandro
authors.initials: A
authors.lastname: Balsa
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Gomez-Reino
authors.forename: Antonio
authors.initials: A
authors.lastname: Gonzalez
mesh_terms: D000328:Adult; D001172:Arthritis, Rheumatoid / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D050835:Interferon Regulatory Factors / Q000235:genetics; D008180:Lupus Erythematosus, Systemic / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D054596:Protein Tyrosine Phosphatase, Non-Receptor Type 22 / Q000235:genetics; D012307:Risk Factors; D050797:STAT4 Transcription Factor / Q000235:genetics
chemical_list: D006680:HLA Antigens; C431713:IRF5 protein, human; D050835:Interferon Regulatory Factors; D050797:STAT4 Transcription Factor; C494090:STAT4 protein, human; C516765:PTPN22 protein, human; D054596:Protein Tyrosine Phosphatase, Non-Receptor Type 22