Keratitis resulting from Thielavia subthermophila Mouchacca.
OBJECTIVE
The purpose of this study was to report the first case of fungal keratitis resulting from Thielavia sp.


METHODS
We conducted a retrospective chart review.


RESULTS
A 10-year old girl presented 2 weeks after ocular plant injury with pain and corneal stromal infiltration with central ulceration and ill-defined margins. Cultures of corneal scrapings and biopsy sequence analysis of the ribosomal internal transcribed spacer region isolated Thielavia subthermophila Mouchacca. Clinically, the organism appeared to respond to topical amphotericin B and oral voriconazole. Best-corrected visual acuity at last follow-up visit counted 0.5.


CONCLUSIONS
A rare case of Thielavia sp. keratitis was successfully treated with topical amphotericin B and oral voriconazole. Newly developed molecular diagnostic tools contribute to the recognition of a widening spectrum of emerging fungal pathogens capable of causing serious ocular infections.
Theoulakis
Panagiotis
P
Klinik und Poliklinik für Augenheilkunde, University of Bern, Inselspital, CH-3010 Bern, Switzerland. ptheoulakis@gmail.com
Goldblum
David
D
Zimmerli
Stefan
S
Muehlethaler
Konrad
K
Frueh
Beatrice E
BE
D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D002648:Child; D003320:Corneal Ulcer / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D004359:Drug Therapy, Combination; D015821:Eye Infections, Fungal / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D005260:Female; D006801:Humans; D009181:Mycoses / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D011743:Pyrimidines / Q000627:therapeutic use; D012189:Retrospective Studies; D020037:Sordariales / Q000302:isolation & purification*; D014230:Triazoles / Q000627:therapeutic use; D065819:Voriconazole
D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D000666:Amphotericin B; D065819:Voriconazole