A magnetically triggered composite membrane for on-demand drug delivery.
Nanocomposite membranes based on thermosensitive, poly(N-isopropylacrylamide)-based nanogels and magnetite nanoparticles have been designed to achieve "on-demand" drug delivery upon the application of an oscillating magnetic field. On-off release of sodium fluorescein over multiple magnetic cycles has been successfully demonstrated using prototype membrane-based devices. The total drug dose delivered was directly proportional to the duration of the "on" pulse. The membranes were noncytotoxic, were biocompatible, and retained their switchable flux properties after 45 days of subcutaneous implantation.
Hoare
Todd
T
Department of Chemical Engineering, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4L7, Canada.
Santamaria
Jesus
J
Goya
Gerardo F
GF
Irusta
Silvia
S
Lin
Debora
D
Lau
Samantha
S
Padera
Robert
R
Langer
Robert
R
Kohane
Daniel S
DS
D000178:Acrylamides / Q000737:chemistry*; D000180:Acrylic Resins; D004305:Dose-Response Relationship, Drug; D016503:Drug Delivery Systems; D019793:Fluorescein / Q000737:chemistry; D005782:Gels / Q000737:chemistry; D008280:Magnetics; D008567:Membranes, Artificial; D053768:Metal Nanoparticles; D011108:Polymers / Q000737:chemistry*; D013696:Temperature
D000178:Acrylamides; D000180:Acrylic Resins; D005782:Gels; D008567:Membranes, Artificial; D011108:Polymers; C052970:poly-N-isopropylacrylamide; D019793:Fluorescein