Interleukin 4 receptor alpha (IL4R) and calcium-activated chloride channel 1 (CLCA1) genes map to donkey chromosome.
The results obtained in the present study enabled the physical map of the donkey genome to be extended with markers associated with recurrent airway obstruction (RAO), a major performance-limiting disease of Equidae. The equine BAC clone containing the IL4R and CLCA1 genes were localized to EAS 14q13 and EAS 6q15 respectlivy by fluorescent in situ hybridization. Identification of their locus confirmed the distribution of syntenic regions between the domestic horse and the domestic donkey within the chromosomes analysed.
Bugno
M
M
Department of Immuno- and Cytogenetics, National Research Institute of Animal Production, Balice, Poland. mbugno@izoo.krakow.pl
Slota
E
E
Witarski
W
W
Gerber
V
V
Klukowska-Roetzler
J
J
D000818:Animals; D015220:Calcium Channels / Q000235:genetics*; D018118:Chloride Channels / Q000235:genetics*; D002871:Chromosome Banding; D033481:Chromosomes, Mammalian; D018397:Equidae / Q000235:genetics*; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D020161:Physical Chromosome Mapping / Q000379:methods; D019948:Receptors, Interleukin-4 / Q000235:genetics*
D015220:Calcium Channels; D018118:Chloride Channels; D019948:Receptors, Interleukin-4