title: Reducing effect of a Phaseolus vulgaris dry extract on food intake, body weight, and glycemia in rats.
abstract: Extracts of kidney beans ( Phaseolus vulgaris ) are known to reduce food intake and glycemia in rodents and humans. This study evaluated the effect of a novel extract of P. vulgaris on food (regular food pellets, starch-enriched diet, and chocolate-flavored beverage) intake, body weight, and glycemia in rats. The effect of the combination of the colecistokinin (CCK) receptor antagonist, lorglumide, and P. vulgaris dry extract on food intake was also investigated. Administration of doses of P. vulgaris dry extract devoid of any behavioral toxicity dose-dependently decreased food intake (irrespective of the diet), body weight gain, and glycemia. Pretreatment with lorglumide blocked the reducing effect of P. vulgaris dry extract on food intake. The capacity of this P. vulgaris dry extract to reduce food intake, body weight, and glycemia in rats may be due to (a) inhibition of alpha-amylase, (b) stimulation of CCK release from the intestinal brush border cells, and/or (c) interference with the central mechanism(s) regulating appetite, food intake, and food palatability.
authors.affiliation: CNR Institute of Neuroscience, Cagliari, Italy.
authors.forename: Noemi
authors.initials: N
authors.lastname: Fantini
authors.forename: Claudia
authors.initials: C
authors.lastname: Cabras
authors.forename: Carla
authors.initials: C
authors.lastname: Lobina
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Colombo
authors.forename: Gian Luigi
authors.initials: GL
authors.lastname: Gessa
authors.forename: Antonella
authors.initials: A
authors.lastname: Riva
authors.forename: Fabio
authors.initials: F
authors.lastname: Donzelli
authors.forename: Paolo
authors.initials: P
authors.lastname: Morazzoni
authors.forename: Ezio
authors.initials: E
authors.lastname: Bombardelli
authors.forename: Mauro A M
authors.initials: MA
authors.lastname: Carai
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis*; D001835:Body Weight / Q000187:drug effects*; D002766:Cholecystokinin / Q000378:metabolism; D004347:Drug Interactions; D004435:Eating / Q000187:drug effects*; D002149:Energy Intake / Q000187:drug effects; D007422:Intestines / Q000648:ultrastructure; D008297:Male; D008871:Microvilli / Q000378:metabolism; D027805:Phaseolus / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology*; D011377:Proglumide / Q000031:analogs & derivatives / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D011949:Receptors, Cholecystokinin / Q000037:antagonists & inhibitors; D000516:alpha-Amylases / Q000037:antagonists & inhibitors
chemical_list: D001786:Blood Glucose; D010936:Plant Extracts; D011949:Receptors, Cholecystokinin; D002766:Cholecystokinin; D000516:alpha-Amylases; D011377:Proglumide; C048181:lorglumide