Toxicity of a novel suspension concentrate of niclosamide against Biomphalaria glabrata.
As a new suspension concentrate of niclosamide (SCN) was more effective in controlling Oncomelania snails than a wettable powder of the same drug, it was tested against Biomphalaria glabrata. There were no differences in the effect of the suspension concentrate, the wettable powder of niclosamide and ball-milled pure niclosamide against the adult snails, but at after 48h 0.125mg/l SCN killed 100% of eggs compared with 84.3% for WPN and 17.7% for pure niclosamide. Because of the improved handling characteristics of SCN over the other formulations, further field tests on Biompharia and Bulinus species are warranted.
Dai
Jian-rong
JR
Jiangsu Institute of Parasitic Diseases, Key Laboratory on Technology for Parasitic Disease Prevention and Control, Ministry of Health, Jiangsu Provincial Key Laboratory on Molecular Biology of Parasites, Jiangsu Provincial Key Subject on Parasitic Diseases, Wuxi 214064, Jiangsu Province, People's Republic of China.
Coles
Gerald C
GC
Wang
Wei
W
Liang
You-sheng
YS
D000818:Animals; D000923:Anticestodal Agents / Q000633:toxicity*; D001700:Biomphalaria / Q000187:drug effects*; D009534:Niclosamide / Q000633:toxicity*; D012552:Schistosomiasis / Q000517:prevention & control; D018675:Toxicity Tests
D000923:Anticestodal Agents; D009534:Niclosamide