title: Soft polypropylene mesh, but not cadaveric dermis, significantly improves outcomes in midline hernia repairs using the components separation technique.
abstract: BACKGROUND
  The search continues for the "ideal" repair of the midline ventral hernia, and the components separation technique has a low, but still concerning, hernia recurrence rate. The authors hypothesize that adding prosthetic or bioprosthetic meshes to the midline closure during components separation would reduce recurrence rates with minimal added morbidity.
  
  
  METHODS
  Over a 3-year period, patients had a components separation procedure where either acellular cadaveric dermis (n = 26) or soft polypropylene mesh (n = 28) was used as an intraperitoneal underlay for reinforcement of the midline repair, but not as a "bridging material." In 36 operations, the mesh or cadaveric dermis was placed at the time of the components separation, and in the remaining cases (n = 18), the underlay was used to treat a recurrence after components separation.
  
  
  RESULTS
  Cadaveric dermis was associated with a 46 percent "true" recurrence rate that required reoperation (mean follow-up, 17.3 months), whereas soft polypropylene mesh had a significantly lower recurrence rate of 11 percent (p = 0.0057) during a follow-up period of 16 months. Because of a higher incidence of concomitant bowel surgery and contamination in the cadaveric dermis group, additional subset analysis of uncontaminated cases was performed, demonstrating a 61 percent recurrence rate for cadaveric dermis compared with 12 percent for soft polypropylene (p = 0.0017). No significant differences in major and minor complications were seen between groups.
  
  
  CONCLUSIONS
  Soft polypropylene mesh, but not acellular dermis, demonstrates acceptably low complication and hernia recurrence rates when used as a reinforcement of the midline ventral hernia closure in conjunction with components separation.
authors.affiliation: Chicago, Ill. From the Department of Surgery, Division of Plastic and Reconstructive Surgery, Northwestern University, Feinberg School of Medicine.
authors.forename: Jason H
authors.initials: JH
authors.lastname: Ko
authors.forename: David M
authors.initials: DM
authors.lastname: Salvay
authors.forename: Benjamin C
authors.initials: BC
authors.lastname: Paul
authors.forename: Edward C
authors.initials: EC
authors.lastname: Wang
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Dumanian
mesh_terms: D000328:Adult; D000368:Aged; D001672:Biocompatible Materials; D002102:Cadaver; D003094:Collagen; D020405:Dermis / Q000637:transplantation; D005260:Female; D006555:Hernia, Ventral / Q000601:surgery*; D006801:Humans; D007813:Laparotomy / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D011126:Polypropylenes; D012008:Recurrence; D013526:Surgical Mesh; D055815:Young Adult
chemical_list: C440568:Alloderm; D001672:Biocompatible Materials; D011126:Polypropylenes; D003094:Collagen