title: Total synthesis of gambierol.
abstract: The total synthesis of gambierol has been achieved utilizing an oxiranyl anion strategy in an iterative manner. Synthetic highlights of this route include direct carbon-carbon formation on epoxides, sulfonyl-assisted 6-endo cyclization, and expansion reaction of tetrahydropyranyl rings to oxepanes to forge the polycyclic architecture of the target molecule.
authors.affiliation: Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku, Nagoya 468-8503, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Furuta
authors.forename: Yuki
authors.initials: Y
authors.lastname: Hasegawa
authors.forename: Yuji
authors.initials: Y
authors.lastname: Mori
mesh_terms: D002922:Ciguatoxins / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D008968:Molecular Conformation; D013237:Stereoisomerism; D035964:Oxocins
chemical_list: D002922:Ciguatoxins; C435770:gambierol; D035964:Oxocins