[Effect of Helicobacter pylori eradication on childhood acute idiopathic thrombocytopenic purpura].
OBJECTIVE
To evaluate the effect of Helicobacter pylor (Hp) eradication in children with acute idiopathic thrombocytopenic purpura (ITP).


METHODS
Ninety-three children with acute ITP and Hp infection were divided into two groups and treated with prednisone and Hp eradication (group A, 51 cases) or with prednisone without Hp eradication (group B, 42 cases).


RESULTS
The Hp eradication rate was 94.1% in group A. No difference was found in the therapeutic effects on IPT between the two groups, but the recurrence rate in one year in group A was significantly lower than that in group B.


CONCLUSIONS
NHp eradication does not obviously enhance the therapeutic effect on childhood acute ITP, but can decrease the relapse rate in one year. HP eradication therapy is recommended in children with acute ITP and Hp infection.
Li
Chao-Xia
CX
Department of Pediatrics, Second Hospital of Yueyang City, Yueyang, China. lizhaoxia08@sina.com
Liu
Di-Jun
DJ
Pan
Chun-Qiu
CQ
Sang
Xian-Fu
XF
Li
Xu
X
D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D005260:Female; D016481:Helicobacter Infections / Q000188:drug therapy*; D016480:Helicobacter pylori / Q000187:drug effects* / Q000276:immunology; D006801:Humans; D008297:Male; D011241:Prednisone / Q000627:therapeutic use; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000276:immunology / Q000382:microbiology*
D000900:Anti-Bacterial Agents; D011241:Prednisone