title: Mechanisms of adipose tissue redistribution with rosiglitazone treatment in various adipose depots.
abstract: Treatment with thiazolidinediones (TZDs) improves glucose homeostasis by increasing insulin sensitivity, but it also leads to weight gain. Our hypothesis was that, in individual adipose depots, there is depot specificity for lipid storage and energy expenditure genes after TZD treatment. After 5 weeks of rosiglitazone treatment on Otsuka Long-Evans Tokushima Fatty (OLETF) rats, an animal model of type 2 diabetes mellitus with obesity, and Long-Evans Tokushima Otsuka rats as controls, we measured changes in lipid storage and energy expenditure gene expression in various adipose depots, such as mesenteric and nonmesenteric adipose tissues (subcutaneous, epididymal, and retroperitoneal). Mesenteric fat masses did not change after TZD treatment in OLETF rats, but nonmesenteric fat masses increased. Messenger RNA expression of lipid storage genes increased in nonmesenteric fat, but energy expenditure gene expression increased in mesenteric fat after rosiglitazone treatment. In conclusion, our findings suggest that TZD treatment may be associated with the depot-specific effects of lipid storage and energy expenditure genes on fat redistribution in individual adipose tissues in OLETF rats.
authors.affiliation: Department of Endocrinology and Metabolism, Hallym University School of Medicine, Hallym University Sacred Heart Hospital, Dongan, 431-070, South Korea.
authors.forename: Jun Goo
authors.initials: JG
authors.lastname: Kang
authors.forename: Cheol-Young
authors.initials: CY
authors.lastname: Park
authors.forename: Sung-Hee
authors.initials: SH
authors.lastname: Ihm
authors.forename: Hyung Joon
authors.initials: HJ
authors.lastname: Yoo
authors.forename: Heesoon
authors.initials: H
authors.lastname: Park
authors.forename: Eun Jung
authors.initials: EJ
authors.lastname: Rhee
authors.forename: Jong Chul
authors.initials: JC
authors.lastname: Won
authors.forename: Won Young
authors.initials: WY
authors.lastname: Lee
authors.forename: Ki Won
authors.initials: KW
authors.lastname: Oh
authors.forename: Sung Woo
authors.initials: SW
authors.lastname: Park
authors.forename: Sun Woo
authors.initials: SW
authors.lastname: Kim
mesh_terms: D050154:Adiposity / Q000187:drug effects*; D000818:Animals; D001483:Base Sequence; D001786:Blood Glucose / Q000032:analysis; D017931:DNA Primers; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy / Q000473:pathology; D004195:Disease Models, Animal; D004734:Energy Metabolism; D020869:Gene Expression Profiling; D005951:Glucose Tolerance Test; D007004:Hypoglycemic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D007328:Insulin / Q000097:blood; D008055:Lipids / Q000097:blood; D051381:Rats; D020318:Rats, Long-Evans; D020133:Reverse Transcriptase Polymerase Chain Reaction; D000077154:Rosiglitazone; D045162:Thiazolidinediones / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D001786:Blood Glucose; D017931:DNA Primers; D007004:Hypoglycemic Agents; D007328:Insulin; D008055:Lipids; D045162:Thiazolidinediones; D000077154:Rosiglitazone