title: Validation of a clinical score to determine the risk of acute renal failure after cardiac surgery.
abstract: OBJECTIVE
  Preoperative assessment of risk factors for postoperative acute renal failure (ARF) is a key point in the management of cardiac surgery patients. A reliable evaluation of individual risk permits the efficient application of prophylactic and therapeutic measures to patients with increased risk of ARF. In 2005, Thakar published a scoring system to determine the ARF risk prior to surgery. The score allowed calculation of the incidence of postoperative ARF requiring dialysis (ARF-D) with a high level of precision.
  
  
  METHODS
  In order to examine the reproducibility of the results on different patient populations, we retrospectively applied the scoring system to 3,508 cardiac surgery patients at the Goettingen University Hospital.
  
  
  RESULTS
  We found a qualitative correlation between the score value and ARF-D, but prognostic significance, when judged by the area under the receiver operating characteristic (ROC) curve, was considerably reduced. Also, the incidence of ARF-D in the Goettingen population was remarkably higher than the incidence shown by Thakar for patients with the same score.
  
  
  CONCLUSIONS
  The correlation between score values and incidence of ARF-D shows that the Thakar score is qualitatively transferable to cardiac surgery patients from other centres. Though the score allows the discrimination between patients with higher or lower risks of ARF-D within the Goettingen collective, it was not suitable to estimate the real incidence of postoperative ARF-D with sufficient precision.
authors.affiliation: Department of Anesthesiology, Emergency and Intensive Care Medicine, University Hospital Goettingen, Goettingen, Germany. dheise1@gwdg.de
authors.forename: Daniel
authors.initials: D
authors.lastname: Heise
authors.forename: Daniela
authors.initials: D
authors.lastname: Sundermann
authors.forename: Anselm
authors.initials: A
authors.lastname: Braeuer
authors.forename: Michael
authors.initials: M
authors.lastname: Quintel
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology* / Q000628:therapy; D000368:Aged; D000369:Aged, 80 and over; D006348:Cardiac Surgical Procedures / Q000009:adverse effects*; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011300:Preoperative Care / Q000379:methods; D011379:Prognosis; D017582:Renal Replacement Therapy