Science to practice: can an enzyme-sensitive MR contrast agent be used to image inflammation in aneurysms?
DeLeo et al have demonstrated in an animal model that inflammation associated with aneurysms can be evaluated noninvasively with magnetic resonance (MR) imaging and use of activatable contrast agents.
Mahmood
Umar
U
Department of Radiology, Division of Nuclear Medicine and Molecular Imaging, Harvard Medical School, 55 Fruit St, White 427, Boston, MA 02114, USA. umahmood@mgh.harvard.edu
D000818:Animals; D002340:Carotid Artery Diseases / Q000201:enzymology* / Q000473:pathology*; D017536:Carotid Artery, Common / Q000201:enzymology* / Q000473:pathology*; D002533:Cerebral Angiography; D003287:Contrast Media / Q000737:chemistry* / Q000494:pharmacology; D004108:Dilatation, Pathologic / Q000201:enzymology / Q000473:pathology; D004195:Disease Models, Animal; D019786:Gadolinium DTPA / Q000737:chemistry* / Q000494:pharmacology; D007089:Image Enhancement / Q000379:methods; D007249:Inflammation / Q000201:enzymology / Q000473:pathology; D002532:Intracranial Aneurysm / Q000201:enzymology* / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009195:Peroxidase / Q000378:metabolism*; D011817:Rabbits
D003287:Contrast Media; D009195:Peroxidase; D019786:Gadolinium DTPA