title: A single-nucleotide polymorphism (-670) of the maternal Fas gene is associated with intrauterine growth restriction.
abstract: OBJECTIVE
  We sought to determine whether the Fas (-670) single-nucleotide polymorphism is associated with intrauterine growth restriction.
  
  
  METHODS
  Twenty-seven pregnant women with intrauterine growth restriction in the absence of preeclampsia and 50 pregnant women with uncomplicated pregnancies were studied. DNA was extracted from maternal and infant buccal smears and allelic discrimination was performed for Fas (-670). Student t test, chi2, and z tests were used.
  
  
  RESULTS
  There were no differences in maternal age, race, or parity between the intrauterine growth restriction and control patients. Mothers of intrauterine growth restriction infants had a significantly different genotype distribution for this single nucleotide polymorphism, and for the ratio of GG genotype (GG, AA: 0.41, 0.18 maternal intrauterine growth restriction; 0.14, 0.32 controls; respectively, P=.03). These genotype differences were significantly different in white, but not black mothers with intrauterine growth restriction (P=.03, and .3; respectively). In contrast, no differences were found in infants' Fas (-670) single-nucleotide polymorphism genotypes.
  
  
  CONCLUSIONS
  This study demonstrates an association between the maternal Fas (-670) single-nucleotide polymorphism and the development of intrauterine growth restriction.
authors.affiliation: Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Westchester Medical Center, New York Medical College, and Department of Pediatrics, Maria Fareri Children's Hospital, Valhalla, NY 10595, USA.
authors.forename: Royland
authors.initials: R
authors.lastname: Robinson
authors.forename: Chaur-Dong
authors.initials: CD
authors.lastname: Hsu
authors.forename: Allyson L
authors.initials: AL
authors.lastname: Chesebro
authors.forename: John
authors.initials: J
authors.lastname: Nguyen
authors.forename: Noorjahan
authors.initials: N
authors.lastname: Ali
authors.forename: Hima
authors.initials: H
authors.lastname: Maramreddy
authors.forename: Lance A
authors.initials: LA
authors.lastname: Parton
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005317:Fetal Growth Retardation / Q000235:genetics*; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D019014:fas Receptor / Q000235:genetics*
chemical_list: C491901:FAS protein, human; D019014:fas Receptor