title: Urinary nitric oxide excretion in infants with eczema.
abstract: Eczema is characterized by inflammation of the skin and is commonly associated with food allergy. It has been suggested that nitric oxide (NO) is an important player in eczema, food allergy and intestinal inflammation. The aim of this study was to assess the levels of urinary NO breakdown products in infants with eczema and the effect of eczema treatment on NO levels. Ninety-four infants with eczema, 58 boys and 36 girls, with a mean age of 7.5 ± 5.2 months (mean ± s.d.) at inclusion were examined twice with an interval of 6 wk. The sum of nitrite and nitrate was measured colorimetrically in urinary samples from both visits and compared with clinical data concerning eczema severity, nutrition, gastrointestinal symptoms, asthma and skin prick positivity. The levels of NO products increased significantly from the first to the second visit: 289; 374 μm (median; IQR) vs. 457; 678 μm (median; IQR) (p < 0.001) in parallel with a significant improvement of the eczema. After eczema treatment consisting of skin care and elimination diet during the 6-wk interval between evaluations, the NO levels approached the values previously found in healthy children. The results support previous studies indicating that the homeostasis of nitrogen radicals is disturbed in childhood eczema.
authors.affiliation: Division of Pediatrics, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, University of Linköping, Linköping, Sweden. irene.devenney@lio.se
authors.forename: Irene
authors.initials: I
authors.lastname: Devenney
authors.forename: Gunilla
authors.initials: G
authors.lastname: Norrman
authors.forename: Tony
authors.initials: T
authors.lastname: Forslund
authors.forename: Karin
authors.initials: K
authors.lastname: Fälth-Magnusson
authors.forename: Tommy
authors.initials: T
authors.lastname: Sundqvist
mesh_terms: D000367:Age Factors; D001942:Breast Feeding; D018450:Disease Progression; D004485:Eczema / Q000150:complications / Q000175:diagnosis* / Q000178:diet therapy / Q000503:physiopathology; D005260:Female; D006706:Homeostasis; D006801:Humans; D007223:Infant; D008297:Male; D016269:Milk Hypersensitivity / Q000150:complications / Q000175:diagnosis* / Q000178:diet therapy / Q000503:physiopathology; D009569:Nitric Oxide / Q000031:analogs & derivatives / Q000652:urine*; D012737:Sex Factors; D012882:Skin Tests
chemical_list: D009569:Nitric Oxide