title: Influence of the vesicular bilayer structure on the sorption of ethylbenzyl alcohol.
abstract: The influence of the physicochemical properties of the vesicular bilayer on the sorption of poorly water soluble compounds was investigated with pulsed field gradient 1H nuclear magnetic resonance (PFG-NMR) for the case of phosphatidylcholine and dioctadecyldimethylammonium bromide (DODAB), using 4-ethylbenzyl alcohol as a model compound. Hereby, the effect of bilayer thickness at a constant physicochemical state was studied using a range of phosphatidylcholines of varying chain lengths, whereas DODAB was preferred to check the influence of the bilayer physicochemical state since this cationic lipid is characterized by three different states within the studied temperature range. When the phospholipid alkyl chain length was changed, no differences were observed in the sorption which was linked to the surface-mediated sorption. On the other hand, when the chemical composition was preserved but the temperature and thus the physical state of the bilayer were changed, the sorption in dioctadecyldimethylammonium bromide (DODAB) vesicles changed dramatically. From those experiments, a strong relationship between the ordering of the surfactant molecules and the sorption can be assumed.
authors.affiliation: Particle and Interfacial Technology Group, Faculty of Bioscience Engineering, Ghent University, Coupure links 653, B-9000 Gent, Belgium. Pieter.Saveyn@Ugent.be
authors.forename: Pieter
authors.initials: P
authors.lastname: Saveyn
authors.forename: Joke
authors.initials: J
authors.lastname: De Geeter
authors.forename: Davy
authors.initials: D
authors.lastname: Sinnaeve
authors.forename: Paul
authors.initials: P
authors.lastname: Van der Meeren
authors.forename: José C
authors.initials: JC
authors.lastname: Martins
mesh_terms: D000042:Absorption; D001592:Benzyl Alcohols / Q000737:chemistry*; D004058:Diffusion; D008051:Lipid Bilayers / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D010713:Phosphatidylcholines / Q000737:chemistry; D000644:Quaternary Ammonium Compounds / Q000737:chemistry; D012995:Solubility; D013696:Temperature; D014867:Water / Q000737:chemistry
chemical_list: D001592:Benzyl Alcohols; D008051:Lipid Bilayers; D010713:Phosphatidylcholines; D000644:Quaternary Ammonium Compounds; D014867:Water; C015831:dimethyldioctadecylammonium; C007656:alpha-ethylbenzyl alcohol