Immunotherapeutic strategies for Alzheimer's disease treatment.
Naturally occurring antibodies against amyloid-beta peptides have been found in human cerebrospinal fluid and in the plasma of healthy individuals, but were significantly lower in Alzheimer's disease (AD) patients, suggesting that AD may be an immunodeficient disorder. The performance of anti-amyloid-beta antibodies in transgenic mice models of AD showed that they are delivered to the central nervous system, preventing and dissolving amyloid-beta plaques. Moreover, these antibodies protected the mice from learning and age-related memory deficits. Active and/or passive immunization against the amyloid-beta peptide has been proposed as a method for preventing and/or treating AD. Immunotherapy represents fascinating ways to test the amyloid hypothesis and offers genuine opportunities for AD treatment, but requires careful antigen and antibody selection to maximize efficacy and minimize adverse events.
Solomon
Beka
B
Department of Molecular Microbiology and Biotechnology, George S. Wise Faculty of Life Sciences, Tel-Aviv University, Tel Aviv, Israel. beka@post.tau.ac.il
D000544:Alzheimer Disease / Q000628:therapy*; D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D007116:Immunization, Passive; D051379:Mice; D008822:Mice, Transgenic