Integron class 1 reservoir among highly resistant gram-negative microorganisms recovered at a Dutch teaching hospital.
Integrons play an important role in the dissemination of resistance genes among bacteria. Nearly 70% of highly resistant gram-negative bacteria isolated at a tertiary care hospital harbored an integron. Epidemiologic analysis suggests that horizontal gene transfer is an important mechanism of resistance spread and has a greater contribution than cross-transmission to levels of resistance in settings where highly resistant gram-negative bacteria are endemic.
Mooij
Marlies J
MJ
Department of Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam.
Willemsen
Ina
I
Lobbrecht
Marilie
M
Vandenbroucke-Grauls
Christina
C
Kluytmans
Jan
J
Savelkoul
Paul H M
PH
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D022761:Gene Transfer, Horizontal; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D016905:Gram-Negative Bacterial Infections / Q000453:epidemiology* / Q000382:microbiology; D006784:Hospitals, Teaching / Q000706:statistics & numerical data*; D006801:Humans; D019426:Integrases / Q000235:genetics; D032023:Integrons / Q000235:genetics*; D007362:Intensive Care Units; D008826:Microbial Sensitivity Tests; D009426:Netherlands / Q000453:epidemiology; D015995:Prevalence
D000900:Anti-Bacterial Agents; D019426:Integrases