title: The study of regulatory T cells and NKT cells in Japan: a historical perspective.
abstract: Immune regulation plays an important role in maintaining homeostasis of the immune system. A number of Japanese immunologists have made significant contributions to the elucidation of the mechanisms of immune regulation. In particular, lymphocyte populations that could regulate immune responses-for example regulatory T cells and NKT cells-have been extensively analyzed. Here, we present an overview of research on immune regulation by highlighting the work of several Japanese contributors.
authors.affiliation: World Premier International Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan. arase@biken.osaka-u.ac.jp
authors.forename: Hisashi
authors.initials: H
authors.lastname: Arase
authors.forename: Ken-ichiro
authors.initials: K
authors.lastname: Seino
mesh_terms: D000818:Animals; D016207:Cytokines / Q000266:history / Q000276:immunology*; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D007564:Japan; D055611:Natural Killer T-Cells / Q000276:immunology*; D011948:Receptors, Antigen, T-Cell / Q000266:history / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
chemical_list: D016207:Cytokines; D011948:Receptors, Antigen, T-Cell