title: Symptoms 'unexplained by organic disease' in 1144 new neurology out-patients: how often does the diagnosis change at follow-up?
abstract: It has been previously reported that a substantial proportion of newly referred neurology out-patients have symptoms that are considered by the assessing neurologist as unexplained by 'organic disease'. There has however been much controversy about how often such patients subsequently develop a disease diagnosis that, with hindsight, would have explained the symptoms. We aimed to determine in a large sample of new neurology out-patients: (i) what proportion are assessed as having symptoms unexplained by disease and the diagnoses given to them; and (ii) how often a neurological disorder emerged which, with hindsight, explained the original symptoms. We carried out a prospective cohort study of patients referred from primary care to National Health Service neurology clinics in Scotland, UK. Measures were: (i) the proportion of patients with symptoms rated by the assessing neurologist as 'not at all' or only 'somewhat explained' by 'organic disease' and the neurological diagnoses recorded at initial assessment; and (ii) the frequency of unexpected new diagnoses made over the following 18 months (according to the primary-care physician). One thousand four hundred and forty-four patients (30% of all new patients) were rated as having symptoms 'not at all' or only 'somewhat explained' by 'organic disease'. The most common categories of diagnosis were: (i) organic neurological disease but with symptoms unexplained by it (26%); (ii) headache disorders (26%); and (iii) conversion symptoms (motor, sensory or non-epileptic attacks) (18%). At follow-up only 4 out of 1030 patients (0.4%) had acquired an organic disease diagnosis that was unexpected at initial assessment and plausibly the cause of the patients' original symptoms. Eight patients had died at follow-up; five of whom had initial diagnoses of non-epileptic attacks. Seven other types of diagnostic change with very different implications to a 'missed diagnosis' were found and a new classification of diagnostic revision is presented. One-third of new neurology out-patients are assessed as having symptoms 'unexplained by organic disease'. A new diagnosis, which with hindsight explained the original symptoms, rarely became apparent to the patient's primary care doctor in the 18 months following the initial hospital consultation.
authors.affiliation: Division of Clinical Neurosciences, School of Molecular and Clinical Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK. jon.stone@ed.ac.uk
authors.forename: Jon
authors.initials: J
authors.lastname: Stone
authors.forename: A
authors.initials: A
authors.lastname: Carson
authors.forename: R
authors.initials: R
authors.lastname: Duncan
authors.forename: R
authors.initials: R
authors.lastname: Coleman
authors.forename: R
authors.initials: R
authors.lastname: Roberts
authors.forename: C
authors.initials: C
authors.lastname: Warlow
authors.forename: C
authors.initials: C
authors.lastname: Hibberd
authors.forename: G
authors.initials: G
authors.lastname: Murray
authors.forename: R
authors.initials: R
authors.lastname: Cull
authors.forename: A
authors.initials: A
authors.lastname: Pelosi
authors.forename: J
authors.initials: J
authors.lastname: Cavanagh
authors.forename: K
authors.initials: K
authors.lastname: Matthews
authors.forename: R
authors.initials: R
authors.lastname: Goldbeck
authors.forename: R
authors.initials: R
authors.lastname: Smyth
authors.forename: J
authors.initials: J
authors.lastname: Walker
authors.forename: A D
authors.initials: AD
authors.lastname: Macmahon
authors.forename: M
authors.initials: M
authors.lastname: Sharpe
mesh_terms: D000328:Adult; D003291:Conversion Disorder / Q000175:diagnosis / Q000503:physiopathology; D003951:Diagnostic Errors; D005260:Female; D005500:Follow-Up Studies; D006261:Headache / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000150:complications / Q000175:diagnosis* / Q000209:etiology; D009460:Neurologic Examination; D010045:Outpatients; D018579:Patient Selection; D011379:Prognosis; D016896:Treatment Outcome