title: Nitazoxanide kills replicating and nonreplicating Mycobacterium tuberculosis and evades resistance.
abstract: We report here that nitazoxanide (NTZ) and its active metabolite kill replicating and nonreplicating M. tuberculosis at low microg/mL levels. NTZ appears to evade resistance, as we were unable to recover resistant colonies, using up to 10(12) colony forming units. Therefore, NTZ is a novel lead compound that kills replicating and nonreplicating M. tuberculosis by a novel mechanism of action, which appears to bypass the development of resistance.
authors.affiliation: Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York 10065, USA.
authors.forename: Luiz Pedro S
authors.initials: LP
authors.lastname: de Carvalho
authors.forename: Gang
authors.initials: G
authors.lastname: Lin
authors.forename: Xiuju
authors.initials: X
authors.lastname: Jiang
authors.forename: Carl
authors.initials: C
authors.lastname: Nathan
mesh_terms: D000977:Antiparasitic Agents; D000995:Antitubercular Agents / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004351:Drug Resistance; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000254:growth & development; D009574:Nitro Compounds; D013844:Thiazoles / Q000494:pharmacology*
chemical_list: D000977:Antiparasitic Agents; D000995:Antitubercular Agents; D009574:Nitro Compounds; D013844:Thiazoles; C041747:nitazoxanide