title: Intelligent medical diagnostics via molecular logic.
abstract: In this communication, we describe the integration of microarray sensor technology with logic capability for screening combinations of proteins and DNA in a biological sample. In this system, we have demonstrated the use of a single platform amenable to both protein detection and protein-DNA detection using molecular logic gates. The pattern of protein and DNA inputs results in fluorescence outputs according to a truth table for AND and INHIBIT gates, thereby demonstrating the feasibility of performing medical diagnostics using a logic gate design. One possible application of this technique would be direct screening of various medical conditions that are dependent on combinations of diagnostic markers.
authors.affiliation: Department of Chemistry, Tufts University, 62 Talbot Avenue, Medford, Massachusetts 02155, USA.
authors.forename: Tania
authors.initials: T
authors.lastname: Konry
authors.forename: David R
authors.initials: DR
authors.lastname: Walt
mesh_terms: D004247:DNA / Q000032:analysis / Q000378:metabolism; D003933:Diagnosis; D006801:Humans; D008128:Logic; D046228:Microarray Analysis; D011506:Proteins / Q000032:analysis / Q000378:metabolism
chemical_list: D011506:Proteins; D004247:DNA