Effects of maternal hyperleptinaemia during lactation on short-term memory/learning, anxiety-like and novelty-seeking behavioral traits of adult male rats.
The objective of the present study was to evaluate whether maternal hyperleptinaemia programs anxiety-like and novelty-seeking behaviors as well as short-term memory/learning in adult male Wistar rats. During the first 10 days of lactation dams were s.c. injected with either murine leptin (LEP) or saline (CON). Adult LEP offspring displayed less anxiety-like behavior and had better memory performance than CON ones, indicating that maternal hyperleptinaemia has specific long lasting behavioral effects at adulthood.
Fraga-Marques
Mabel C
MC
Laboratório de Neurofisiologia, Departamento de Ciências Fisiológicas, Instituto de Biologia Roberto Alcantara Gomes, Centro Biomédico, Universidade do Estado do Rio de Janeiro, Brazil.
Moura
Egberto G
EG
Silva
Juliana Oliveira
JO
Claudio-Neto
Sylvio
S
Pereira-Toste
Fernanda
F
Passos
Magna C F
MC
Lisboa
Patrícia C
PC
Manhães
Alex C
AC
D000818:Animals; D000831:Animals, Newborn; D001007:Anxiety; D001522:Behavior, Animal / Q000187:drug effects; D005106:Exploratory Behavior / Q000187:drug effects*; D005260:Female; D007774:Lactation / Q000097:blood / Q000502:physiology*; D020738:Leptin / Q000097:blood / Q000494:pharmacology*; D008297:Male; D018811:Maternal Exposure; D018782:Maze Learning / Q000187:drug effects*; D008568:Memory / Q000187:drug effects*; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D013037:Spatial Behavior
D020738:Leptin