[Therapeutic options for perioperatively acquired platelet dysfunctions].
Increased intra-operative and postoperative blood loss might be caused by acquired platelet function disorders. In particular because conventional coagulation analyses and platelet count fail to detect impaired platelet function, implementation of bedside-tests for platelet function in the peri-operative period is desirable according to the results of retrospective studies. Following adequate adjustment of basic conditions of haemostasis (e.g. temperature, pH, Ca2+-concentration, haematocrit) a pharmacological approach with desmopressin (1-desamino-8-d-arginine vasopressin; DDAVP) or tranexamic acid potentially represents a low cost alternative to platelet transfusions with minor side effects.
Weber
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CF
Klinik für Anästhesiologie, Intensivmedizin und Schmerztherapie, Klinikum der Johann Wolfgang Goethe-Universität Frankfurt am Main, Frankfurt. Christian.Weber@kgu.de
Schneider
A C
AC
Kirschning
T
T
Hofstetter
C
C
Zacharowski
K
K
Görlinger
K
K
D000933:Antifibrinolytic Agents / Q000627:therapeutic use; D016063:Blood Loss, Surgical / Q000503:physiopathology; D001791:Blood Platelet Disorders / Q000188:drug therapy / Q000209:etiology / Q000628:therapy*; D003894:Deamino Arginine Vasopressin / Q000627:therapeutic use; D015942:Factor VIIa / Q000627:therapeutic use; D005340:Fibrinogen / Q000627:therapeutic use; D006487:Hemostasis; D006801:Humans; D016343:Monitoring, Intraoperative; D019990:Perioperative Care; D010979:Platelet Function Tests; D017713:Platelet Transfusion; D011994:Recombinant Proteins / Q000627:therapeutic use; D014148:Tranexamic Acid / Q000627:therapeutic use
D000933:Antifibrinolytic Agents; D011994:Recombinant Proteins; D014148:Tranexamic Acid; D005340:Fibrinogen; D015942:Factor VIIa; D003894:Deamino Arginine Vasopressin