Production of (R)-1-phenylethanols through bioreduction of acetophenones by a new fungus isolate Trichothecium roseum.
A total of 120 fungal strains were isolated from soil samples and evaluated in the bioreduction of substituted acetophenones to the corresponding (R)-alcohols. Among these strains, isolate Trichothecium roseum EBK-18 was highly effective in the production of (R)-alcohols with excellent enantioselectivity (ee > 99%). Gram scale preparation of (R)-1-phenylethanol is reported.
Zilbeyaz
Kani
K
Faculty of Sciences, Department of Chemistry, Ataturk University, Erzurum 25240, Turkey.
Taskin
Mesut
M
Kurbanoglu
Esabi B
EB
Kurbanoglu
Namudar I
NI
Kilic
Hamdullah
H
D000098:Acetophenones / Q000378:metabolism*; D006999:Hypocreales / Q000302:isolation & purification* / Q000378:metabolism*; D010084:Oxidation-Reduction; D010626:Phenylethyl Alcohol / Q000737:chemistry* / Q000378:metabolism*; D012988:Soil Microbiology; D013237:Stereoisomerism; D013379:Substrate Specificity
D000098:Acetophenones; D010626:Phenylethyl Alcohol; C038699:acetophenone