title: Class IV-G and IV-S lupus nephritis in Chinese patients: a large cohort study from a single center.
abstract: This study is to assess the difference between IV-G and IV-S in a large cohort of Chinese patients with lupus nephritis. The detailed data of patients with subclass IV-G and IV-S were retrospectively analyzed. Serum ANCA and anti-C1q antibodies were detected. A total of 172 cases were classified as class IV, including 152 cases with IV-G and 20 cases with IV-S. In IV-S, the level of haemoglobin was significantly higher (P = 0.024), proteinuria was milder (P = 0.003), serum creatinine was lower (P = 0.021), serum C3 was higher (P = 0.045) and the ratio of positive serum anti-cardiolipin antibodies was higher (P = 0.014). On pathological evaluation, the ratio of glomerular fibrinoid necrosis was significantly higher (P = 0.006) and the score of endocapillary hypercellualrity, interstitial inflammation and total activity indices was significantly lower (P < 0.001, P = 0.01, P = 0.006, respectively) in IV-S. The frequency of serum ANCA was significantly higher in IV-S than that in IV-G (20 vs 4.6%, P = 0.008). The frequencies of anti-C1q IgG1 and IgG3 subclass were significantly higher in IV-G (P = 0.006, P = 0.011, respectively). There are significant differences in clinical and pathological manifestations between IV-S and IV-G lupus nephritis which need further investigation.
authors.affiliation: Renal Division, Department of Medicine, Peking University First Hospital, Institute of Nephrology, Peking University, Key laboratory of Renal Disease, Ministry of Health of China, Beijing 100034, PR China.
authors.forename: F
authors.initials: F
authors.lastname: Yu
authors.forename: Y
authors.initials: Y
authors.lastname: Tan
authors.forename: L-H
authors.initials: LH
authors.lastname: Wu
authors.forename: S-N
authors.initials: SN
authors.lastname: Zhu
authors.forename: G
authors.initials: G
authors.lastname: Liu
authors.forename: M-H
authors.initials: MH
authors.lastname: Zhao
mesh_terms: D000328:Adult; D000818:Animals; D017153:Antibodies, Anticardiolipin / Q000097:blood / Q000276:immunology; D044466:Asian People; D001323:Autoantibodies / Q000097:blood / Q000276:immunology; D015331:Cohort Studies; D015922:Complement C1q / Q000276:immunology; D005260:Female; D006801:Humans; D007678:Kidney Glomerulus / Q000473:pathology; D008181:Lupus Nephritis / Q000097:blood / Q000276:immunology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D017153:Antibodies, Anticardiolipin; D001323:Autoantibodies; D015922:Complement C1q