title: A photoluminescent nanocrystal-based signaling protocol highly sensitive to nerve agents and highly toxic organophosphate pesticides.
abstract: A photoluminescent II-VI group semiconductor nanocrystal (NC)-based signaling platform composed of thioglycolic acid capped CdS NCs and acetylcholinesterase-acetylthiocholine enzyme catalytic reaction system was developed that was shown to be highly sensitive to nerve agents and toxic organophosphate pesticides with detection limits down to sub-nM levels. This new sensing protocol does not require troublesome conjugation of biomacromolecules onto the surface of NCs.
authors.affiliation: Department of Chemistry and The MOE Key Laboratory of Analytical Sciences, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Yu
authors.forename: Jiang-Shan
authors.initials: JS
authors.lastname: Shen
authors.forename: Hai-Hong
authors.initials: HH
authors.lastname: Bai
authors.forename: Lei
authors.initials: L
authors.lastname: Guo
authors.forename: Ji-Jun
authors.initials: JJ
authors.lastname: Tang
authors.forename: Yun-Bao
authors.initials: YB
authors.lastname: Jiang
authors.forename: Jian-Wei
authors.initials: JW
authors.lastname: Xie
mesh_terms: D000042:Absorption; D000109:Acetylcholine / Q000737:chemistry / Q000378:metabolism; D000110:Acetylcholinesterase / Q000378:metabolism; D015374:Biosensing Techniques / Q000379:methods*; D019187:Cadmium Compounds / Q000737:chemistry; D008163:Luminescent Measurements; D053758:Nanoparticles / Q000737:chemistry*; D009420:Nervous System / Q000187:drug effects*; D010755:Organophosphates / Q000032:analysis* / Q000633:toxicity*; D010575:Pesticides / Q000032:analysis* / Q000633:toxicity*; D013440:Sulfides / Q000737:chemistry; D013864:Thioglycolates / Q000737:chemistry
chemical_list: D019187:Cadmium Compounds; D010755:Organophosphates; D010575:Pesticides; D013440:Sulfides; D013864:Thioglycolates; C034939:cadmium sulfide; D000110:Acetylcholinesterase; D000109:Acetylcholine