A new cytotoxic iridoid from Callicarpa nudiflora.
A new iridoid, named nudifloside (1), together with three known compounds, was isolated from the EtOH extract of the aerial parts of Callicarpa nudiflora Hook. The structures were elucidated by a study of their physical and spectral data. Nudifloside (1) and the isolated known compound linearoside (2) displayed inhibitory effects towards chronic myelogenous leukaemia K562 cell line, with IC(50) values of 20.7 and 36.0 microg mL(-1), respectively.
Mei
Wen-Li
WL
Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, 571101, Hainan, PR China.
Han
Zhuang
Z
Cui
Hai-Bin
HB
Zhao
You-Xing
YX
Deng
Yuan-Yuan
YY
Dai
Hao-Fu
HF
D032408:Callicarpa / Q000737:chemistry*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D039823:Iridoids / Q000737:chemistry* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D035261:Plant Components, Aerial / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*
D039823:Iridoids; D010936:Plant Extracts