5'-Lipophilic conjugates of oligonucleotides as components of cell delivery systems.
The approach to the synthesis of 5'-lipophilic conjugates of functional nucleic acids based on a combination of H-phosphonate and phosphoramidite methods is presented.
Iglina
A A
AA
Institute of Chemical Biology and Fundamental Medicine SB RAS, 630090 Novosibirsk, Russia.
Meschaninova
M I
MI
Venyaminova
A G
AG
D008055:Lipids / Q000737:chemistry*; D009841:Oligonucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D063065:Organophosphonates / Q000737:chemistry; D009943:Organophosphorus Compounds / Q000737:chemistry
D008055:Lipids; D009841:Oligonucleotides; D063065:Organophosphonates; D009943:Organophosphorus Compounds; C434331:phosphoramidite