Implication of beta3-adrenoceptors in the antidepressant-like effects of amibegron using Adrb3 knockout mice in the chronic mild stress.
The involvement of the beta3-adrenoceptor in the antidepressant-like effects of the beta3-adrenoceptor-agonist amibegron is addressed in the chronic mild stress, using adrenergic beta3-receptor knockout (Adrb3tm1Lowl) mice. Amibegron (3 mg/kg/day, i.p., 33 days), attenuated the physical alteration due to the application of repeated stress in wild-type littermates, but not in knockout mice. This result suggests that the beta3-adrenoceptor plays a predominant role in mediating antidepressant-like actions of amibegron.
Stemmelin
Jeanne
J
Sanofi-aventis, CNS Research, 31 avenue Paul Vaillant-Couturier, 92220 Bagneux, France. jeanne.stemmelin@sanofi-aventis.com
Cohen
Caroline
C
Yalcin
Ipek
I
Keane
Peter
P
Griebel
Guy
G
D058667:Adrenergic beta-3 Receptor Agonists; D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D051379:Mice; D018345:Mice, Knockout; D022702:Receptors, Adrenergic, beta-3 / Q000235:genetics; D013312:Stress, Physiological / Q000187:drug effects* / Q000235:genetics; D013764:Tetrahydronaphthalenes / Q000494:pharmacology*
D058667:Adrenergic beta-3 Receptor Agonists; D000318:Adrenergic beta-Agonists; D000928:Antidepressive Agents; D022702:Receptors, Adrenergic, beta-3; D013764:Tetrahydronaphthalenes; C076252:amibegron