title: [An in vitro evaluation of the antibacterial activity of chitosan-based thermosensitive hydrogel against periodontal pathogens].
abstract: OBJECTIVE
  To evaluate the in vitro antibacterial activity of chitosan - quaternized chitosan/alpha, beta-glycerophosphate (CS-HTCC/GP) thermosensitive hydrogel against three periodontal pathogens- P. gingivalis, P. intermedia, and A. actinomycetemcomitans.
  
  
  METHODS
  An agar diffusion method was used to assess the antimicrobial property of CS-HTCC/GP thermosensitive hydrogel with minimum inhibitory concentration (MIC) and inhibitory zone measurement. SPSS13.0 software package was used for Student's t test.
  
  
  RESULTS
  Three periodontal pathogens strains were all susceptible to CS-HTCC/GP thermosensitive hydrogel. Both matrix of thermosensitive hydrogel and antibiotic exhibited stronger antibacterial activity especially when they were combined.
  
  
  CONCLUSIONS
  CS-HTCC/GP thermosensitive hydrogel is not only as the vehicle of antibiotics which joins the local drug delivery system but as an activator which takes part in the antibacterial process.
authors.affiliation: Department of Stomatology, The Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, Shandong Province, China. jqx_1@163.com
authors.forename: Qiu-xia
authors.initials: QX
authors.lastname: Ji
authors.forename: Jing
authors.initials: J
authors.lastname: Deng
authors.forename: Xin-bo
authors.initials: XB
authors.lastname: Yu
authors.forename: Quan-chen
authors.initials: QC
authors.lastname: Xu
authors.forename: Xiao-yan
authors.initials: XY
authors.lastname: Xu
mesh_terms: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D048271:Chitosan; D016503:Drug Delivery Systems; D005994:Glycerophosphates; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D066298:In Vitro Techniques; D008826:Microbial Sensitivity Tests; D013696:Temperature
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D005994:Glycerophosphates; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D048271:Chitosan; C031463:beta-glycerophosphoric acid