title: Effect of clindamycin hydrochloride on oral malodor, plaque, calculus, and gingivitis in dogs with periodontitis.
abstract: Periodontal disease is considered the most common disease of dogs and cats. The clinical sign most frequently reported by clients is oral malodor. Clindamycin hydrochloride has been used for several years for the treatment of periodontal disease in both cats and dogs. This study was designed to assess the effect of clindamycin HCl when used in two different post-prophylaxis treatment regimens on oral malodor and periodontal disease in a controlled clinical trial. This study demonstrated that a 5-day postprophylaxis regimen was significantly effective in reducing oral malodor compared with a dental prophylaxis alone. Clindamycin HCl significantly reduced oral malodor from the animals' baseline levels through 42 days. In addition, although no effect was observed on periodontal pocket depth, this treatment regimen also resulted in significant reductions in dental plaque, dental calculus, and gingival bleeding.
authors.affiliation: Indiana University, School of Dentistry, 1121 West Michigan Street, Indianapolis, IN 46202-5186, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: Warrick
authors.forename: G A
authors.initials: GA
authors.lastname: Inskeep
authors.forename: T D
authors.initials: TD
authors.lastname: Yonkers
authors.forename: G K
authors.initials: GK
authors.lastname: Stookey
authors.forename: T H
authors.initials: TH
authors.lastname: Ewing
mesh_terms: D000818:Animals; D002981:Clindamycin / Q000008:administration & dosage / Q000627:therapeutic use*; D003728:Dental Calculus / Q000188:drug therapy / Q000662:veterinary*; D003773:Dental Plaque / Q000188:drug therapy / Q000662:veterinary*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004334:Drug Administration Schedule; D005260:Female; D005891:Gingivitis / Q000188:drug therapy / Q000662:veterinary*; D006209:Halitosis / Q000188:drug therapy / Q000662:veterinary; D008297:Male; D010518:Periodontitis / Q000188:drug therapy / Q000662:veterinary*
chemical_list: D002981:Clindamycin