The type III TGFbeta receptor regulates directional migration: new tricks for an old dog.
The type III transforming growth factor beta (TGFbeta) receptor (T beta RIII or betaglycan) is a TGFbeta superfamily co-receptor. Loss of T beta RIII expression occurs in a broad spectrum of human cancers including cancers of the breast, kidney, lung, ovary, pancreas and prostate. T beta RIII suppresses cancer progression, in part, by reducing cancer cell motility. This T beta RIII function is independent of its TGFbeta signaling role, with T beta RIII activating Cdc42 via its interaction with the scaffolding protein beta-arrestin2 to re-organize the actin cytoskeleton, decrease directional persistence and inhibit random migration in both epithelial-derived cancer cells and normal epithelial cells. These studies contribute to a growing body of literature supporting essential and non-redundant roles for T beta RIII and emphasize the importance of continued investigation of T beta RIII and other signaling co-receptors.
Mythreye
Karthikeyan
K
Blobe
Gerard C
GC
D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism; D019390:Arrestins / Q000378:metabolism; D002465:Cell Movement; D003599:Cytoskeleton; D006801:Humans; D011509:Proteoglycans / Q000378:metabolism / Q000502:physiology*; D018125:Receptors, Transforming Growth Factor beta / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction; D000071557:beta-Arrestins; D020764:cdc42 GTP-Binding Protein / Q000378:metabolism; D020741:rho GTP-Binding Proteins / Q000378:metabolism
D048868:Adaptor Proteins, Signal Transducing; D019390:Arrestins; C492009:GIPC1 protein, human; D011509:Proteoglycans; D018125:Receptors, Transforming Growth Factor beta; D000071557:beta-Arrestins; C071736:betaglycan; D020764:cdc42 GTP-Binding Protein; D020741:rho GTP-Binding Proteins