title: A multicomponent coupling sequence for direct access to substituted quinolines.
abstract: A titanium-catalyzed three-component coupling reaction can be used to generate tautomers of N-aryl-1,3-diimines. Simple treatment of these products with acetic acid leads to cyclization forming quinoline derivatives in a one-pot procedure. The primary amines employed can be substituted anilines, aminonaphthalenes, or even heterocyclic amines, which leads to a variety of fused-ring heterocyclic frameworks. The one-pot yields varied from 25-71% for the 18 examples presented in this study.
authors.affiliation: Michigan State University, Department of Chemistry, East Lansing, Michigan 48823, USA.
authors.forename: Supriyo
authors.initials: S
authors.lastname: Majumder
authors.forename: Kevin R
authors.initials: KR
authors.lastname: Gipson
authors.forename: Aaron L
authors.initials: AL
authors.lastname: Odom
mesh_terms: D000085:Acetates / Q000737:chemistry; D000588:Amines / Q000737:chemistry; D011804:Quinolines / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D000085:Acetates; D000588:Amines; D011804:Quinolines