title: Site-specific modification of RNA by functionality-transfer ODN probes.
abstract: Efficient methods for the modification of RNA molecules have been expected as innovative biological tools and therapeutic methods. In this study, the development of a general method for site-specific RNA modification by the functionality-transfer ODN probes has been investigated. Site-specific and cytosine-selective RNA modifications were achieved by the functionality-transfer reaction. It was shown that the base and site-selectivity were due to the close proximity of the reactants in the DNA-RNA duplexes.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
authors.forename: Kazumitsu
authors.initials: K
authors.lastname: Onizuka
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Taniguchi
authors.forename: Takamasa
authors.initials: T
authors.lastname: Nishioka
authors.forename: Shigeki
authors.initials: S
authors.lastname: Sasaki
mesh_terms: D003596:Cytosine / Q000737:chemistry; D009691:Nucleic Acid Denaturation; D015345:Oligonucleotide Probes / Q000737:chemistry*; D012313:RNA / Q000737:chemistry*
chemical_list: D015345:Oligonucleotide Probes; D012313:RNA; D003596:Cytosine