Three-component synthesis of alpha-branched amines under Barbier-like conditions.
An array of alpha-branched amines has been prepared by using an expedient three-component Mannich-type reaction among organic halides, aldehyde derivatives, and amines. The experimental procedure, which is characterized by its simplicity, employs zinc dust for the in situ generation of organozinc reagents. We show that this Barbier-like protocol constitutes a useful entry to diarylmethylamines, 1,2-diarylethylamines, alpha- or beta-amino esters, benzylamines, and beta-arylethylamines.
Le Gall
Erwan
E
Electrochimie et Synthèse Organique, Institut de Chimie et des Matériaux Paris Est-UMR 7182 CNRS-Université Paris 12, 2-8 rue Henri Dunant, 94320 Thiais, France. legall@glvt-cnrs.fr
Haurena
Caroline
C
Sengmany
Stéphane
S
Martens
Thierry
T
Troupel
Michel
M
D000588:Amines / Q000138:chemical synthesis*; D015394:Molecular Structure
D000588:Amines