title: Docking simulation of polyamines on a kissing-loop RNA dimer.
abstract: Polyamines, especially branched polyamines such as tetrakis(3-aminopropyl)ammonium (Taa), stabilize the tertiary structure of RNA molecules. In this study, we examined the polyamine binding site of the HIV-1 dimerization initiation site (DIS) in the kissing-loop dimer by the docking simulation. It was found that Taa binds predominantly to the kissing loop interaction site of DIS.
authors.affiliation: Department of Life and Environmental Sciences, Chiba Institute of Technology, Narashino-shi, Chiba 275-0016, Japan.
authors.forename: Misaki
authors.initials: M
authors.lastname: Imai
authors.forename: Daisuke
authors.initials: D
authors.lastname: Chikatsu
authors.forename: Emire
authors.initials: E
authors.lastname: Inomata
authors.forename: Tairo
authors.initials: T
authors.lastname: Oshima
authors.forename: Gota
authors.initials: G
authors.lastname: Kawai
mesh_terms: D001665:Binding Sites; D003198:Computer Simulation; D019281:Dimerization; D015497:HIV-1 / Q000235:genetics*; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D011073:Polyamines / Q000737:chemistry*; D000644:Quaternary Ammonium Compounds / Q000737:chemistry*; D012367:RNA, Viral / Q000737:chemistry*
chemical_list: D011073:Polyamines; D000644:Quaternary Ammonium Compounds; D012367:RNA, Viral; C053493:tetrakis(3-aminopropyl)ammonium; C035585:caldopentamine