The haplotype of the MxA gene promoter is associated with hepatitis B virus infection in a Chinese population.
OBJECTIVE
The Myxovirus resistance protein A gene (MxA) is a key component of the innate antiviral response and has previously been shown to inhibit several viruses. This study was designed to assess whether the haplotype in the MxA promoter region was associated with hepatitis B virus (HBV) infection in a Chinese population.


METHODS
Three hundred and twelve HBV-infected patients and 317 healthy volunteers were enrolled in this study. Two polymorphisms of -88 and -123 located in the MxA gene promoter were identified by the polymerase chain reaction-restriction fragment length polymorphism method.


RESULTS
The individual possessing haplotype GA, which was constructed by the two polymorphisms of -88G and -123A in the MxA gene promoter, was significantly associated with HBV infection [possessing one copy odds ratio (OR)=1.69, 95% confidence interval (CI) 1.21-2.35; two copy OR=2.84, 95% CI 1.12-7.21 respectively].


CONCLUSIONS
This case-control study suggested that the haplotype GA in the MxA gene promoter region would increase the susceptibility to HBV infection in a Chinese population.
Cao
Bangwei
B
Department of Anti-Infection and Institute of Clinical Pharmacology, Peking University First Hospital, #1 Xi An Men Da Jie Street, Western District, Beijing, China. caobangwei@yahoo.com.cn
Liu
Xing
X
Hou
Fang
F
Li
Wende
W
Han
Zhonggang
Z
Zhang
Qipeng
Q
Dai
Yue
Y
Xu
Changqing
C
Qi
Huimin
H
D000328:Adult; D016022:Case-Control Studies; D005260:Female; D019204:GTP-Binding Proteins / Q000235:genetics*; D006239:Haplotypes; D006509:Hepatitis B / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D064547:Myxovirus Resistance Proteins; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic
C579071:MX1 protein, human; D064547:Myxovirus Resistance Proteins; D019204:GTP-Binding Proteins