Acridone-labeled DNA aptamer for the detection of biomolecules.
An acridone-labeled DNA aptamer was synthesized to produce an aptamer probe. This aptamer probe could detect a specific molecule based on conformational changes upon binding of the specific molecules and the quenching of acridone emission.
Ozaki
Hiroaki
H
Department of Chemistry and Chemical Biology, Graduate School of Engineering, Gunma University, Kiryu, Gunma 376-8515, Japan. h-ozaki@chem-bio.gunma-u.ac.jp
Hagiwara
Yasuhisa
Y
Asakura
Hiromi
H
Kuwahara
Masayasu
M
D000166:Acridines / Q000737:chemistry*; D054831:Acridones; D052157:Aptamers, Nucleotide / Q000737:chemistry*; D001120:Arginine / Q000031:analogs & derivatives* / Q000032:analysis; D004247:DNA / Q000737:chemistry; D005456:Fluorescent Dyes / Q000737:chemistry*; D009838:Oligodeoxyribonucleotides / Q000737:chemistry; D013050:Spectrometry, Fluorescence; D013696:Temperature
D000166:Acridines; D054831:Acridones; D052157:Aptamers, Nucleotide; D005456:Fluorescent Dyes; D009838:Oligodeoxyribonucleotides; C069339:argininamide; C041300:acridone; D004247:DNA; D001120:Arginine