title: Sclerosing haemangioma with a predominant sclerotic pattern: an unusual pulmonary lesion which can be misdiagnosed.
abstract: OBJECTIVE
  An unusual sclerosing haemangioma of the lung with a predominant sclerotic pattern is described.
  
  
  CONCLUSIONS
  The patient was a 51-year-old male, presenting with a well-circumscribed nodule, 0,6 cm in diameter, located in the lower lobe of the left lung. He is alive and well 9 years after surgical excision of the nodule. Microscopically, the lesion was well demarcated and mostly composed of sclerotic tissue, with numerous irregular entrapped alveolar spaces The characteristic bland, round cells with abundant pale cytoplasm, immunohistochemically positive for TTF-1 and negative for cytokeratin, were limited to small clusters embedded in the stroma at the periphery of the nodule. The most important differential diagnostic considerations of the sclerotic variant of pulmonary sclerosing haemangioma are briefly discussed.
authors.affiliation: Unità Operativa di Anatomia Patologica, Ospedale S. Maria Nuova, Viale Risorgimento 80, 42100 Reggio Emilia, Italy. cavazza.alberto@asmn.re.it
authors.forename: Alberto
authors.initials: A
authors.lastname: Cavazza
authors.forename: Sandra
authors.initials: S
authors.lastname: Pellegrino
authors.forename: Innocenza
authors.initials: I
authors.lastname: Putrino
authors.forename: Loredana
authors.initials: L
authors.lastname: De Marco
authors.forename: Giulio
authors.initials: G
authors.lastname: Rossi
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis; D014408:Biomarkers, Tumor / Q000032:analysis; D004268:DNA-Binding Proteins / Q000032:analysis; D003937:Diagnosis, Differential; D006391:Hemangioma / Q000175:diagnosis; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D047868:Pulmonary Sclerosing Hemangioma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D014157:Transcription Factors
chemical_list: D014408:Biomarkers, Tumor; D004268:DNA-Binding Proteins; C504003:TTF1 protein, human; D014157:Transcription Factors