Potential roles of myosin VI in cell motility.
There is now increasing evidence that myosin motor proteins, together with the dynamic actin filament machinery and associated adhesion proteins, play crucial roles in the events leading to motility at the leading edge of migrating cells. Myosins exist as a large superfamily of diverse ATP-dependent motors, and in the present review, we focus on the unique minus-end-directed myosin VI, briefly discussing its potential functions in cell motility.
Chibalina
Margarita V
MV
Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Hills Road, Cambridge, UK.
Puri
Claudia
C
Kendrick-Jones
John
J
Buss
Folma
F
D000199:Actins / Q000378:metabolism; D000818:Animals; D015815:Cell Adhesion Molecules / Q000502:physiology; D002462:Cell Membrane / Q000378:metabolism; D002465:Cell Movement / Q000502:physiology*; D016764:Cell Polarity; D016326:Extracellular Matrix Proteins / Q000378:metabolism; D006056:Golgi Apparatus / Q000378:metabolism; D018995:Myosin Heavy Chains / Q000378:metabolism*; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology; D011956:Receptors, Cell Surface; D015398:Signal Transduction / Q000502:physiology
D000199:Actins; D015815:Cell Adhesion Molecules; D016326:Extracellular Matrix Proteins; D011956:Receptors, Cell Surface; C089785:myosin VI; D018995:Myosin Heavy Chains