Unbound cephalothin pharmacokinetics in adult burn patients are related to the elapsed time after injury.
Cephalothin (cefalotin) pharmacokinetics were evaluated for nine severely burned patients (42% +/- 9% mean burn areas) and five healthy volunteers by using non-plasma-protein-bound concentration-time profiles. Burn patients gave increased mean residence times (36%) and reduced total clearances (25%). Mean residence times and distribution volumes increased between 1 and 4 days posttrauma, suggesting that burn patient pharmacokinetics change during the initial fluid resuscitation phase of treatment.
Dalley
Andrew J
AJ
University of Queensland, Burns Trauma & Critical Care Research Centre, Royal Brisbane & Women's Hospital, Herston, Brisbane, Queensland, Australia. a.dalley@uq.edu.au
Deans
Renae
R
Lipman
Jeffrey
J
Venkatesh
Bala
B
Rudd
Michael
M
Roberts
Michael S
MS
Cross
Sheree E
SE
D000328:Adult; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D002056:Burns / Q000188:drug therapy*; D002512:Cephalothin / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D055815:Young Adult
D000900:Anti-Bacterial Agents; D002512:Cephalothin