title: Estrogen receptor alpha (ER-alpha) gene polymorphism in patients from the Lodz region of Poland with sporadic endometrial cancer.
abstract: OBJECTIVE
  Estrogens play a crucial role in the pathogenesis and progression of endometrial cancer. The gene ER-alpha is polymorphic and gene variability could contribute to the level of protein biosynthesis.
  
  
  METHODS
  The aim of this study was to evaluate PvuII and XbaI polymorphism of the ER-alpha gene in 120 postmenopausal women with endometrial cancer in DNA samples obtained from cancer tissue. The polymorphisms were determined by PCR-RFLP methods.
  
  
  RESULTS
  The distribution of the genotypes of PvuII and XbaI polymorphism of ER-alpha in both controls and patients did not differ significantly from those predicted by the Hardy-Weinberg distribution. There were no significant differences in genotype distributions and allele frequencies between subgroups assigned to histological stage.
  
  
  CONCLUSIONS
  The results suggest that the PvuII polymorphism of ER-alpha gene as well as XbaI polymorphism may not be linked with appearance and development of endometrial cancer.
authors.affiliation: Department of Menopausal Disease, Institute of Polish Mother's Memorial Hospital Lodz, Poland. smolbea@wp.pl
authors.forename: A
authors.initials: A
authors.lastname: Sobczuk
authors.forename: B
authors.initials: B
authors.lastname: Smolarz
authors.forename: H
authors.initials: H
authors.lastname: Romanowicz-Makowska
authors.forename: T
authors.initials: T
authors.lastname: Pertyński
mesh_terms: D016889:Endometrial Neoplasms / Q000235:genetics*; D047628:Estrogen Receptor alpha / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length
chemical_list: D047628:Estrogen Receptor alpha