title: Decreased PM10 exposure attenuates age-related lung function decline: genetic variants in p53, p21, and CCND1 modify this effect.
abstract: BACKGROUND
  Decreasing exposure to airborne particulates was previously associated with reduced age-related decline in lung function. However, whether the benefit from improved air quality depends on genetic background is not known. Recent evidence points to the involvement of the genes p53 and p21 and of the cell cycle control gene cyclin D1 (CCND1) in the response of bronchial cells to air pollution.
  
  
  OBJECTIVE
  We determined in 4,326 participants of the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA) whether four single-nucleotide polymorphisms in three genes [CCND1 (rs9344 [P242P], rs667515), p53 (rs1042522 [R72P]), and p21 (rs1801270 [S31R])] modified the previously observed attenuation of the decline in the forced expiratory flow between 25% and 75% of the forced vital capacity (FEF(25-75)) associated with improved air quality.
  
  
  METHODS
  Subjects of the prospective population-based SAPALDIA cohort were assessed in 1991 and 2002 by spirometry, questionnaires, and biological sample collection for genotyping. We assigned spatially resolved concentrations of particulate matter with aerodynamic diameter < or = 10 microm (PM(10)) to each participant's residential history 12 months before the baseline and follow-up assessments.
  
  
  RESULTS
  The effect of diminishing PM(10) exposure on FEF(25-75) decline appeared to be modified by p53 R72P, CCND1 P242P, and CCND1 rs667515. For example, a 10-microg/m(3) decline in average PM(10) exposure over an 11-year period attenuated the average annual decline in FEF(25-75) by 21.33 mL/year (95% confidence interval, 10.57-32.08) among participants homozygous for the CCND1 (P242P) GG genotype, by 13.72 mL/year (5.38-22.06) among GA genotypes, and by 6.00 mL/year (-4.54 to 16.54) among AA genotypes.
  
  
  CONCLUSIONS
  Our results suggest that cell cycle control genes may modify the degree to which improved air quality may benefit respiratory function in adults.
authors.affiliation: Department of Chronic Disease Epidemiology, Institute of Social and Preventive Medicine, University of Zurich, Sumatrastrasse 30, Zurich, Switzerland.
authors.forename: Medea
authors.initials: M
authors.lastname: Imboden
authors.forename: Joel
authors.initials: J
authors.lastname: Schwartz
authors.forename: Christian
authors.initials: C
authors.lastname: Schindler
authors.forename: Ivan
authors.initials: I
authors.lastname: Curjuric
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Berger
authors.forename: Sally L J
authors.initials: SL
authors.lastname: Liu
authors.forename: Erich W
authors.initials: EW
authors.lastname: Russi
authors.forename: Ursula
authors.initials: U
authors.lastname: Ackermann-Liebrich
authors.forename: Thierry
authors.initials: T
authors.lastname: Rochat
authors.forename: Nicole M
authors.initials: NM
authors.lastname: Probst-Hensch
mesh_terms: D000328:Adult; D000393:Air Pollutants / Q000633:toxicity*; D001483:Base Sequence; D015331:Cohort Studies; D019938:Cyclin D1 / Q000235:genetics*; D017931:DNA Primers; D005260:Female; D016158:Genes, p53; D014644:Genetic Variation; D006801:Humans; D008168:Lung / Q000187:drug effects* / Q000502:physiology; D008297:Male; D010316:Particle Size; D016283:Proto-Oncogene Proteins p21(ras) / Q000235:genetics*; D012129:Respiratory Function Tests
chemical_list: D000393:Air Pollutants; C530104:CCND1 protein, human; D017931:DNA Primers; D019938:Cyclin D1; D016283:Proto-Oncogene Proteins p21(ras)