title: An automated method for preparation of [(18)F]sodium fluoride for injection, USP to address the technetium-99m isotope shortage.
abstract: The worldwide shortage of technetium-99m has created an immediate and urgent need for access to [(18)F]sodium fluoride for PET imaging of bone metastasis. In order to facilitate global availability of [(18)F]sodium fluoride for diagnostic nuclear medicine imaging procedures, a straightforward method for rapid production of [(18)F]sodium fluoride for injection, USP, using a modified GE Tracerlab FX-FN is presented.
authors.affiliation: The University of Michigan School of Medicine, Ann Arbor, MI, USA.
authors.forename: Brian G
authors.initials: BG
authors.lastname: Hockley
authors.forename: Peter J H
authors.initials: PJ
authors.lastname: Scott
mesh_terms: D001331:Automation; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary; D005462:Fluorine Radioisotopes; D007553:Isotope Labeling / Q000379:methods; D049268:Positron-Emission Tomography / Q000379:methods; D019275:Radiopharmaceuticals; D012969:Sodium Fluoride; D013667:Technetium / Q000600:supply & distribution*
chemical_list: D005462:Fluorine Radioisotopes; D019275:Radiopharmaceuticals; D013667:Technetium; D012969:Sodium Fluoride