title: Inhibition of aggregation of [Pd]-bacteriochlorophyllides in mesoporous silica.
abstract: Aggregation is a major factor affecting the photophysical properties of chlorophylls. For two [Pd]-bacteriochlorophyll derivatives that are currently under clinical testing as sensitizers for photodynamic therapy, aggregation control in aqueous solution has been studied with folded-sheet mesoporous silica (FSM) of different pore sizes (20, 45, 83 A) and with detergent (Triton X-100). With both the moderately polar WST09 and the highly polar WST11, no pigment oligomers were formed in FSM, and the monomer-dimer equilibrium was shifted toward the monomer with decreasing pore diameter.
authors.affiliation: Department Biologie I - Botanik, Universität München, Germany.
authors.forename: Jörg
authors.initials: J
authors.lastname: Dandler
authors.forename: Hugo
authors.initials: H
authors.lastname: Scheer
mesh_terms: D000042:Absorption; D001429:Bacteriochlorophylls / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D017830:Octoxynol / Q000494:pharmacology; D010949:Plasma / Q000378:metabolism; D016062:Porosity; D055503:Protein Multimerization / Q000187:drug effects*; D020836:Protein Structure, Quaternary; D012822:Silicon Dioxide / Q000494:pharmacology*; D014867:Water / Q000737:chemistry
chemical_list: D001429:Bacteriochlorophylls; C456120:palladium-bacteriopheophorbide; D014867:Water; D012822:Silicon Dioxide; D017830:Octoxynol; C503696:padeliporfin