title: Flow injection chemiluminescence determination of 6-mercaptopurine based on a new system of potassium permanganate-thioacetamide-sodium hexametaphosphate.
abstract: A novel chemiluminescence method for the determination of 6-mercaptopurine was established based on 6-mercaptopurine inhibition of the chemiluminescence emission of potassium permanganate-thioacetamide-sodium hexametaphosphate system. The peak height was proportional to log 6-mercaptopurine concentration in the range 7.0 × 10(-10) to 1.0 × 10(-7)  g/mL and the detection limit was 1.9 × 10(-11)  g/mL (S/N = 3). The relative standard deviation was 1.5% for the determination of 8.0 × 10(-8)  g/mL 6-mercaptopurine (n = 11). The proposed sensor was successfully applied to the analysis of 6-mercaptopurine in human serum samples.
authors.affiliation: Anhui Key Laboratory of Chemo-Biosensing, College of Chemistry and Materials Science, Anhui Normal University, Wuhu, 241000, China. WangLun@mail.ahnu.edu.cn
authors.forename: Lun
authors.initials: L
authors.lastname: Wang
authors.forename: Bo
authors.initials: B
authors.lastname: Ling
authors.forename: Hongqi
authors.initials: H
authors.lastname: Chen
authors.forename: Ani
authors.initials: A
authors.lastname: Liang
authors.forename: Binbin
authors.initials: B
authors.lastname: Qian
authors.forename: Jie
authors.initials: J
authors.lastname: Fu
mesh_terms: D017022:Flow Injection Analysis / Q000379:methods; D006801:Humans; D007202:Indicators and Reagents; D057230:Limit of Detection; D008163:Luminescent Measurements / Q000379:methods*; D015122:Mercaptopurine / Q000032:analysis / Q000097:blood*; D010710:Phosphates; D011196:Potassium Permanganate; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013853:Thioacetamide
chemical_list: D007202:Indicators and Reagents; D010710:Phosphates; D011196:Potassium Permanganate; D013853:Thioacetamide; D015122:Mercaptopurine; C009285:sodium polymetaphosphate