Differential acetyl cholinesterase inhibition by volatile oils from two specimens of Marlierea racemosa (Myrtaceae) collected from different areas of the Atlantic Rain Forest.
The volatile oil composition and anti-acetyl cholinesterase activity were analyzed in two specimens of Marlierea racemosa growing in different areas of the Atlantic Rain Forest (Cananéia and Caraguatatuba, SP, Brazil). Component identifications were performed by GC/MS and their acetyl cholinesterase inhibitory activity was measured through colorimetric analysis. The major constituent in both specimens was spathulenol (25.1% in Cananéia and 31.9% in Caraguatatuba). However, the first one also presented monoterpenes (41.2%), while in the Carguatatuba plants, this class was not detected. The oils from the plants collected in Cananéia were able to inhibit the acetyl cholinesterase activity by up to 75%, but for oils from the other locality the maximal inhibition achieved was 35%. These results suggested that the monoterpenes are more effective in the inhibition of acetyl cholinesterase activity than sesquiterpenes as these compounds are present in higher amounts in the M. racemosa plants collected in Cananéia.
Souza
Amanda
A
Instituto de Biociências, Universidade de São Paulo, São Paulo, SP, Brazil.
Silva
Michelle C
MC
Cardoso-Lopes
Elaine M
EM
Cordeiro
Inês
I
Sobral
Marcos E G
ME
Young
Maria Cláudia M
MC
Moreno
Paulo R H
PR
D000110:Acetylcholinesterase / Q000378:metabolism; D000544:Alzheimer Disease / Q000188:drug therapy; D001938:Brazil; D002800:Cholinesterase Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D003124:Colorimetry / Q000379:methods; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D006801:Humans; D027822:Myrtaceae / Q000737:chemistry*; D009822:Oils, Volatile / Q000302:isolation & purification* / Q000494:pharmacology; D014329:Tropical Climate
D002800:Cholinesterase Inhibitors; D009822:Oils, Volatile; D000110:Acetylcholinesterase