title: Successful treatment by all-trans retinoic acid in a patient with acute promyelocytic leukemia complicated by liver cirrhosis and polycystic kidney.
abstract: Although all-trans retinoic acid (ATRA) is widely used in acute promyelocytic leukemia (APL), there is little data as to whether or not ATRA is useful for patients with liver and renal failure. A 63-year-old APL patient, complicated by Child-Pugh class A liver cirrhosis and chronic renal failure (creatinine 3.2 mg/dL), was successfully treated with 45 mg/m(2)/day of ATRA. With three courses of chemotherapy, complete remission has been maintained for four years in this patient. Serum trough and maximum ATRA concentration, and the area under the curve (AUC) were not elevated. These observations suggest that full-dose ATRA therapy might be safely applicable to such a complicated case with APL.
authors.affiliation: Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine, Maebashi, Japan.
authors.forename: Arito
authors.initials: A
authors.lastname: Yamane
authors.forename: Norifumi
authors.initials: N
authors.lastname: Tsukamoto
authors.forename: Takayuki
authors.initials: T
authors.lastname: Saitoh
authors.forename: Hideki
authors.initials: H
authors.lastname: Uchiumi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Handa
authors.forename: Masamitsu
authors.initials: M
authors.lastname: Karasawa
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Nojima
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Murakami
mesh_terms: D000970:Antineoplastic Agents / Q000097:blood / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006801:Humans; D006934:Hypercalcemia / Q000097:blood / Q000150:complications; D007676:Kidney Failure, Chronic / Q000097:blood / Q000150:complications; D015473:Leukemia, Promyelocytic, Acute / Q000097:blood / Q000150:complications* / Q000188:drug therapy* / Q000378:metabolism; D008103:Liver Cirrhosis / Q000097:blood / Q000150:complications*; D017093:Liver Failure / Q000097:blood / Q000150:complications; D008297:Male; D008875:Middle Aged; D007690:Polycystic Kidney Diseases / Q000097:blood / Q000150:complications*; D012074:Remission Induction; D014212:Tretinoin / Q000097:blood / Q000493:pharmacokinetics / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; D014212:Tretinoin