IL7RA polymorphisms and chronic inflammatory arthropathies.
The C allele of a single nucleotide polymorphism (SNP), rs6897932, located in the interleukin-7 receptor alpha chain (IL7RA) was recently found to be associated with multiple sclerosis and Type I diabetes. We analysed 13 SNPs in the IL7RA gene in a combined cohort of patients with chronic inflammatory arthropathies (rheumatoid arthritis and juvenile idiopathic arthritis; 368 patients and 532 unaffected subjects). No significant associations with disease were found with the exception of the non-synonymous SNP rs6897932. This SNP showed modest enrichment of the TT genotype in arthritic patients compared with controls [P = 0.02; OR 1.72 (95% CI 1.08-2.75)]. Our data are suggestive for a role of rs6897932 in predisposition to chronic inflammatory arthropathies.
O'Doherty
C
C
School of Pharmacy and Medical Sciences, City East Campus, University of South Australia, Adelaide, Australia.
Alloza
I
I
Rooney
M
M
Vandenbroeck
K
K
D001171:Arthritis, Juvenile / Q000235:genetics; D001172:Arthritis, Rheumatoid / Q000235:genetics*; D016022:Case-Control Studies; D002874:Chromosome Mapping; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000502:physiology; D020395:Receptors, Interleukin-7 / Q000235:genetics*
D020395:Receptors, Interleukin-7; C415350:interleukin-7 receptor, alpha chain