title: Oral herpes simplex virus infection in pregnancy: what are the concerns?
abstract: Although epidemiologic data and the potentially serious effects of transmission of genital herpes from mother to infant during birth have been widely reported, published reports on oral herpes disease in pregnancy remain scarce and no clear management guidelines exist. Thus, questions remain about acquisition, transmission and outcome of infection, especially with respect to acute gingivostomatitis in pregnancy. In response to these questions, we summarize previous reports on herpes simplex virus 1 (HSV-1) oral disease in pregnancy and, briefly, present 2 cases of primary gingivostomatitis in the first trimester of pregnancy, resulting in a favourable outcome for both mother and infant. We also point out the most recent data on rare, potentially severe in outcome, but treatable, primary central nervous system HSV-1 infection in later stages of pregnancy. Finally, we emphasize a multidisciplinary approach to oral HSV disease in pregnancy, with dentist participation in the diagnosis and treatment.
authors.affiliation: Reference Centre for theStudy of Oral Diseases, Florence, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Ficarra
authors.forename: Catalena
authors.initials: C
authors.lastname: Birek
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use; D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use; D005260:Female; D006560:Herpes Labialis / Q000150:complications / Q000517:prevention & control / Q000635:transmission / Q000821:virology; D018259:Herpesvirus 1, Human; D006801:Humans; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000821:virology*; D011256:Pregnancy Outcome; D011264:Pregnancy Trimesters; D013283:Stomatitis, Herpetic / Q000150:complications / Q000517:prevention & control / Q000635:transmission / Q000821:virology*; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents; D000212:Acyclovir