title: Primary cutaneous cribriform apocrine carcinoma: a clinicopathologic and immunohistochemical study of 26 cases of an under-recognized cutaneous adnexal neoplasm.
abstract: BACKGROUND
  Cribriform carcinoma is the histopathologic variant of cutaneous apocrine carcinoma characterized by interconnected solid aggregations of neoplastic cells that are punctuated by small round spaces.
  
  
  OBJECTIVE
  To describe the histopathologic and immunohistochemical characteristics of this under-recognized cutaneous adnexal neoplasm.
  
  
  METHODS
  Twenty-six cases of primary cutaneous cribriform apocrine carcinoma were clinically, histopathologically, and immunohistochemically studied.
  
  
  RESULTS
  Seven neoplasms arose in males and 19 in females. The median age of the patients was 47.8 years. The lower and upper limbs were the most frequent sites. Histopathologically, the neoplasms consisted of well-circumscribed dermal nodules composed of multiple, interconnected, solid aggregations of basophilic epithelial cells that were punctuated by small round spaces. Immunohistochemically, the neoplastic cells expressed immunoreactivity for MNF116, AE1/AE3, Cam 5.2, cytokeratin 7, carcinoembryonic antigen, and epithelial membrane antigen.
  
  
  CONCLUSIONS
  All specimens came from dermatopathology laboratories, and some inherent selection bias may exist.
  
  
  CONCLUSIONS
  Primary cutaneous cribriform apocrine carcinoma is a distinctive but little-known variant of cutaneous apocrine carcinoma.
authors.affiliation: Dermatohistopathologische Gemeinschaftspraxis, Friedrichshafen, Germany.
authors.forename: Arno
authors.initials: A
authors.lastname: Rütten
authors.forename: Heinz
authors.initials: H
authors.lastname: Kutzner
authors.forename: Thomas
authors.initials: T
authors.lastname: Mentzel
authors.forename: Markus
authors.initials: M
authors.lastname: Hantschke
authors.forename: Fritof
authors.initials: F
authors.lastname: Eckert
authors.forename: Jorge
authors.initials: J
authors.lastname: Angulo
authors.forename: Jose Luis
authors.initials: JL
authors.lastname: Rodríguez Peralto
authors.forename: Luis
authors.initials: L
authors.lastname: Requena
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology*; D000328:Adult; D000368:Aged; D001050:Apocrine Glands / Q000473:pathology; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001706:Biopsy; D003528:Carcinoma, Adenoid Cystic / Q000378:metabolism / Q000473:pathology; D003593:Cytoplasm / Q000473:pathology / Q000648:ultrastructure; D003937:Diagnosis, Differential; D004847:Epithelial Cells / Q000473:pathology / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008854:Microscopy, Electron; D008871:Microvilli / Q000473:pathology / Q000648:ultrastructure; D008875:Middle Aged; D018294:Neoplasms, Adnexal and Skin Appendage / Q000378:metabolism* / Q000473:pathology*; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor