title: Primary cortical brain cells influence osteoblast activity.
abstract: The presence of neuropeptides and neuroreceptors in the bone have been reported in several studies. Bone turn-over seems to be controlled by the nervous system. The actual pathway or the control mechanism is still under investigation. In this study we investigate the changes in osteoblast cells if they are in co-culture with primary cortical brain cells. After seven days in co-culture with the primary fetal brain cells the osteoblast cells exhibited hypertrophic morphological changes and showed stronger ALP activity.
authors.affiliation: Department of Orthopaedic Surgery, Louisiana State University Health Sciences Center, Shreveport, LA, USA.
authors.forename: Lucas
authors.initials: L
authors.lastname: Anissian
authors.forename: Michael
authors.initials: M
authors.lastname: Kirby
authors.forename: André
authors.initials: A
authors.lastname: Stark
mesh_terms: D000818:Animals; D016723:Bone Remodeling / Q000502:physiology*; D002452:Cell Count; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000166:cytology / Q000502:physiology*; D018920:Coculture Techniques; D010006:Osteoblasts / Q000166:cytology / Q000502:physiology*; D051381:Rats