[Serotonin receptor gene polymorphism and analgesic sensitivity].
There are gene polymorphisms changing the expression or activation of the serotonin (5-HT) receptors, which are associated with pain. This review showed an availability of 5-HT2A receptor gene polymorphism in analgesic sensitivity. To search gene polymorphisms related to analgesic sensitivity is important to further effective pain management. In future 5-HT2A receptor gene polymorphisms, together with polymorphisms of other genes, may greatly contribute to effective postoperative pain management and personalized medicine.
Aoki
Jun
J
Laboratory of Neurophysiology, Graduate School of Environmental Health Sciences, Azabu University, Sagamihara 229-8501.
Ikeda
Kazutaka
K
Iwahashi
Kazuhiko
K
D020413:3' Untranslated Regions / Q000235:genetics; D000368:Aged; D000700:Analgesics / Q000008:administration & dosage; D000818:Animals; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000235:genetics*; D010149:Postoperative Pain / Q000188:drug therapy / Q000235:genetics; D010597:Pharmacogenetics; D011110:Polymorphism, Genetic; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics*; D011985:Receptors, Serotonin / Q000235:genetics; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics
D020413:3' Untranslated Regions; D000700:Analgesics; D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin; D050486:Serotonin Plasma Membrane Transport Proteins