title: Characterization of the biological behaviour of appendicular osteosarcoma in Rottweilers and a comparison with other breeds: a review of 258 dogs.
abstract: The purpose of this retrospective study was to compare Rottweilers diagnosed with osteosarcoma (OSA) with other breeds to determine whether Rottweilers experienced a more aggressive form of the disease. Two hundred and fifty-eight dogs were evaluated (102 clinical and 156 necropsy cases). In the necropsy population, Rottweilers had a younger mean age at death (7.3 versus 9 years, P = 0.006). There were no significant differences between Rottweilers and other breeds in age at diagnosis, median disease-free interval or survival time. However, Rottweilers were more likely to have metastasis to the brain (7 versus 0%, P = 0.03). These results suggest that OSA in Rottweilers may have a different biological behaviour, but this study did not confirm that these differences were associated with a worse outcome.
authors.affiliation: Department of Clinical Studies, Matthew J. Ryan Veterinary Hospital, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. cmcneill@vet.upenn.edu
authors.forename: C J
authors.initials: CJ
authors.lastname: McNeill
authors.forename: B
authors.initials: B
authors.lastname: Overley
authors.forename: F S
authors.initials: FS
authors.lastname: Shofer
authors.forename: M S
authors.initials: MS
authors.lastname: Kent
authors.forename: C A
authors.initials: CA
authors.lastname: Clifford
authors.forename: M
authors.initials: M
authors.lastname: Samluk
authors.forename: S
authors.initials: S
authors.lastname: Haney
authors.forename: T J
authors.initials: TJ
authors.lastname: Van Winkle
authors.forename: K U
authors.initials: KU
authors.lastname: Sorenmo