title: Asymmetric localisation of planar polarity proteins: Mechanisms and consequences.
abstract: Planar polarisation of tissues is essential for many aspects of developmental patterning. It is regulated by a conserved group of core planar polarity proteins, which localise asymmetrically within cells prior to morphological signs of polarisation. A subset of these core proteins also interact across cell boundaries, mediating intercellular communication that co-ordinates polarity between neighbouring cells. Core protein localisation subsequently mediates changes in the actin cytoskeleton which lead to overt polarisation. In this review we discuss the mechanisms by which the core planar polarity proteins become asymmetrically localised, and the significance of this subcellular localisation for both intercellular communication and downstream effects on the cytoskeleton.
authors.affiliation: MRC Centre for Developmental and Biomedical Genetics and Department of Biomedical Science, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, UK. h.strutt@sheffield.ac.uk
authors.forename: Helen
authors.initials: H
authors.lastname: Strutt
authors.forename: David
authors.initials: D
authors.lastname: Strutt
mesh_terms: D000818:Animals; D002450:Cell Communication; D016764:Cell Polarity; D005110:Extracellular Space / Q000378:metabolism; D021381:Protein Transport; D011506:Proteins / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D011506:Proteins