title: [Effectiveness of S-1 therapy for unresectable/advanced pancreas cancer].
abstract: OBJECTIVE
  Although the susceptibility to chemotherapy of unresectable/advanced pancreatic cancer is very poor, the usefulness of new anticancer drugs, such as S-1, has been reported in recent years. We clinically investigated whether or not S-1 would prolong survival in this study.
  
  
  OBJECTIVE
  17 unresectable pancreatic cancer patients who came for consultation between November 2001 and August 2008 (ten men, seven women). The average age was 72.5 years and performance statuses before medical treatment were 0-2.
  
  
  METHODS
  A group of 8 patients did not use S-1 (non-S-1 group) and a group of a patients (S-1 group)did. The average survival period, one-year survival rate, and hospitalization rate were examined.
  
  
  RESULTS
  The average survival period of the non-S-1 group was 173.1 days, and its one-year survival rate was 12.5%, compared to 435.1 days and 55.6% in the S-1 group. The hospitalization rate was 25.6% in the S-1 group, against 53.1% in the non-S-1 group.
  
  
  CONCLUSIONS
  S-1 treatment for unresectable/advanced pancreatic cancer served to prolong the survival period, suggesting it enabled extension of the recuperation-at-home period.
authors.affiliation: Dept. of Internal Medicine, San-in Rosai Hospital.
authors.forename: Takamasa
authors.initials: T
authors.lastname: Kanbe
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Kishimoto
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Tsunoda
authors.forename: Ryu
authors.initials: R
authors.lastname: Imamoto
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Mukouyama
authors.forename: Eiji
authors.initials: E
authors.lastname: Nishimuki
authors.forename: Michiko
authors.initials: M
authors.lastname: Shabana
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Kojo
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D004338:Drug Combinations; D005260:Female; D006760:Hospitalization; D006801:Humans; D008297:Male; D008875:Middle Aged; D010094:Oxonic Acid / Q000627:therapeutic use*; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000401:mortality; D005641:Tegafur / Q000627:therapeutic use*
chemical_list: D000964:Antimetabolites, Antineoplastic; D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid