A novel mechanism for inflammation-associated  carcinogenesis; an important role of activation-induced  cytidine deaminase (AID) in mutation induction.
Inflammation is a risk for cancer development; however, its mechanism is unknown. Recent studies have revealed that activation-induced cytidine deaminase (AID), which plays essential roles in both class-switch recombination and somatic hypermutation of immunoglobulin gene in B lymphocytes, is aberrantly expressed in non-lymphoid cells not only by H.pylori and HCV infection but also by various proinflammatory cytokines, leading to the generation of gene mutations. These findings not only suggested a new mechanism of inflammation-associated carcinogenesis but has also opened up a new field of tumor biology.
Chiba
Tsutomu
T
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Sakyo, Kyoto, Japan. chiba@kuhp.kyoto-u.ac.jp
Marusawa
Hiroyuki
H
D000818:Animals; D001402:B-Lymphocytes / Q000201:enzymology / Q000276:immunology / Q000502:physiology; D003564:Cytidine Deaminase / Q000276:immunology*; D042822:Genomic Instability; D016481:Helicobacter Infections / Q000276:immunology; D006526:Hepatitis C / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D008099:Liver / Q000201:enzymology / Q000821:virology; D008113:Liver Neoplasms / Q000201:enzymology / Q000821:virology; D009154:Mutation; D016328:NF-kappa B / Q000378:metabolism; D009369:Neoplasms / Q000209:etiology / Q000235:genetics / Q000276:immunology; D013274:Stomach Neoplasms / Q000201:enzymology / Q000382:microbiology; D014758:Viral Core Proteins / Q000378:metabolism; D000098830:AICDA (Activation-Induced Cytidine Deaminase)
D016328:NF-kappa B; D014758:Viral Core Proteins; D000098830:AICDA (Activation-Induced Cytidine Deaminase); D003564:Cytidine Deaminase