title: Autologous stem cell transplant in a patient with Down syndrome and relapsed Hodgkin lymphoma.
abstract: Children with Down syndrome (DS) are at increased risk for the development of acute leukemia but they rarely develop other hematologic malignancies or solid tumors. Despite aggressive supportive care, DS patients have increased risk of treatment related morbidity and mortality compared to other children. There are few reported cases of Hodgkin disease in children with DS, and no reported cases of successful therapy for patients with relapsed disease. We report on a child with DS and relapsed Hodgkin disease who was successfully treated with high-dose chemotherapy and autologous stem cell transplant.
authors.affiliation: Division of Pediatric Hematology/Oncology, Vanderbilt University, Nashville, Tennessee 37232-6310, USA.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Eckrich
authors.forename: Jennifer
authors.initials: J
authors.lastname: Domm
authors.forename: Richard
authors.initials: R
authors.lastname: Ho
authors.forename: James A
authors.initials: JA
authors.lastname: Whitlock
authors.forename: Haydar
authors.initials: H
authors.lastname: Frangoul
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D001761:Bleomycin / Q000008:administration & dosage; D002330:Carmustine / Q000008:administration & dosage; D002648:Child; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D004314:Down Syndrome / Q000150:complications*; D004317:Doxorubicin / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use; D006689:Hodgkin Disease / Q000150:complications / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery*; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D008297:Male; D015080:Mesna / Q000008:administration & dosage; D036102:Peripheral Blood Stem Cell Transplantation; D011241:Prednisone / Q000008:administration & dosage; D011344:Procarbazine / Q000008:administration & dosage; D012008:Recurrence; D012074:Remission Induction; D019172:Transplantation Conditioning; D014182:Transplantation, Autologous; D014747:Vinblastine / Q000008:administration & dosage / Q000031:analogs & derivatives; D014750:Vincristine / Q000008:administration & dosage; D000077235:Vinorelbine
chemical_list: D001761:Bleomycin; D016179:Granulocyte Colony-Stimulating Factor; D011344:Procarbazine; D014750:Vincristine; D014747:Vinblastine; D005047:Etoposide; D004317:Doxorubicin; D003520:Cyclophosphamide; D015080:Mesna; D000077235:Vinorelbine; D002330:Carmustine; D007069:Ifosfamide; D011241:Prednisone