title: 6-Acetylmorphine detected in the absence of morphine in pain management patients.
abstract: Liquid chromatography tandem mass spectrometry was used to identify and confirm the presence of 6-acetylmorphine and morphine in 22,361 urines of pain management patients. Thirty urines tested positive for 6-acetylmorphine above a cutoff of 10 ng/mL. Twenty-three percent of the patients with urinary concentrations of 6-acetylmorphine above 10 ng/mL had urinary morphine concentrations below 300 ng/mL.
authors.affiliation: Millennium Laboratories, San Diego, California 92127, USA. bcrews@becausepainmatters.com
authors.forename: Bridgit
authors.initials: B
authors.lastname: Crews
authors.forename: Charles
authors.initials: C
authors.lastname: Mikel
authors.forename: Sergey
authors.initials: S
authors.lastname: Latyshev
authors.forename: Robert
authors.initials: R
authors.lastname: West
authors.forename: Cameron
authors.initials: C
authors.lastname: West
authors.forename: Amadeo
authors.initials: A
authors.lastname: Pesce
authors.forename: Patrick
authors.initials: P
authors.lastname: Friel
mesh_terms: D000701:Analgesics, Opioid / Q000378:metabolism / Q000592:standards / Q000652:urine*; D053000:Analytic Sample Preparation Methods; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D005966:Glucuronidase / Q000378:metabolism; D006801:Humans; D006868:Hydrolysis; D009020:Morphine / Q000378:metabolism / Q000592:standards / Q000652:urine*; D009022:Morphine Derivatives / Q000592:standards / Q000652:urine*; D010146:Pain / Q000652:urine*; D012016:Reference Values; D021241:Spectrometry, Mass, Electrospray Ionization; D015813:Substance Abuse Detection / Q000592:standards; D053719:Tandem Mass Spectrometry / Q000379:methods; D014481:United States
chemical_list: D000701:Analgesics, Opioid; D009022:Morphine Derivatives; D009020:Morphine; D005966:Glucuronidase; C026979:6-O-monoacetylmorphine