title: Linkage between immunomodulation, neuroprotection and neurogenesis.
abstract: Neuronal protection and restoration are the major goals for the therapy of neurodegenerative diseases, representing a very active field of research. In multiple sclerosis, treatments need to target both the autoimmune inflammation and the pathological neurodegeneration. The optimal therapeutic approach may promote remyelination and axonal repair, and even lead to neuronal renewal. This review article will discuss both endogenous neuroprotective mechanisms and those triggered by potential therapies. Currently employed immunomodulatory treatments and their ability to induce neuroprotection, tissue repair and neurogenesis are also presented.
authors.affiliation: Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel.
authors.forename: Rina
authors.initials: R
authors.lastname: Aharoni
authors.forename: Ruth
authors.initials: R
authors.lastname: Arnon
mesh_terms: D000818:Animals; D006801:Humans; D007155:Immunologic Factors / Q000494:pharmacology* / Q000627:therapeutic use; D009103:Multiple Sclerosis / Q000188:drug therapy* / Q000276:immunology; D009410:Nerve Degeneration / Q000188:drug therapy; D019636:Neurodegenerative Diseases / Q000188:drug therapy / Q000276:immunology; D055495:Neurogenesis / Q000187:drug effects; D018696:Neuroprotective Agents / Q000276:immunology / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D007155:Immunologic Factors; D018696:Neuroprotective Agents