Interleukin-23 receptor gene variants in Hungarian systemic lupus erythematosus patients.
OBJECTIVE
We investigated the association between systemic lupus erythematosus (SLE) and polymorphisms of interleukin-23 receptor (IL23R) gene, which was recently found to be associated with autoimmune diseases, including Crohn's disease, rheumatoid arthritis, psoriasis and ankylosing spondylitis.


METHODS
We analysed 383 SLE patients and 253 controls for rs11805303, rs10889677, rs1004819, rs2201841, rs11209032, 11209026, rs10489629, rs7517847 and rs7530511 variants.


METHODS
The analysis was carried out using PCR-RFLP methods. Logistic regression analysis was used to compare the genotype distributions of the polymorphisms and haplotypes between the SLE patients and healthy controls.


RESULTS
We observed no significant difference of the examined variants between the patient and control groups.


CONCLUSIONS
Our results suggest that neither single nucleotide variants nor haplotypes of IL23R indicate susceptibility to developing SLE in the Hungarian population.
Safrany
Eniko
E
Department of Medical Genetics, University of Pecs, Szigeti 12, 7624 Pecs, Hungary.
Hobor
Renata
R
Jakab
Laszlo
L
Tarr
Tunde
T
Csongei
Veronika
V
Jaromi
Luca
L
Sipeky
Csilla
C
Valasek
Andrea
A
Zeher
Margit
M
Fust
Gyorgy
G
Czirjak
Laszlo
L
Melegh
Bela
B
D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D006814:Hungary; D008180:Lupus Erythematosus, Systemic / Q000208:ethnology* / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D018123:Receptors, Interleukin / Q000235:genetics*
C515500:IL23R protein, human; D018123:Receptors, Interleukin