Postoperative memory prediction in left temporal lobe epilepsy: the Wada test is of no added value to preoperative neuropsychological assessment and MRI.
The contribution of the Wada test (intracarotid amytal procedure, IAP) to predicting postoperative memory outcome in left temporal lobe epilepsy (LTLE) is becoming increasingly controversial when preoperative neuropsychological evaluation and MRI findings are available. We retrospectively analyzed 59 patients with LTLE who underwent en bloc temporal lobe resection. All patients had valid bilateral IAP test results, complete pre- and postoperative neuropsychological evaluation, and MRI grading on a 5-point scale integrating T 2 signal increase and degree of atrophy. Thirty percent of patients showed postoperative memory decline. Multiple regression analysis revealed that significant predictors of decline [F(2.56)=22.71, P<0.001, r(2)=0.448] included preoperative memory learning score [t=-5.89, P<0.001] and MRI classification [t=3.10, P<0.003], but not IAP scores. The IAP is of no added value in the prediction of postoperative memory outcome in LTLE in the presence of comprehensive neuropsychological and MRI data.
Elshorst
N
N
Mara Clinic, Epilepsy Center Bethel, Bielefeld, Germany.
Pohlmann-Eden
B
B
Horstmann
S
S
Schulz
R
R
Woermann
F
F
McAndrews
M P
MP
D000328:Adult; D000654:Amobarbital; D038481:Anterior Temporal Lobectomy / Q000379:methods; D004833:Epilepsy, Temporal Lobe / Q000503:physiopathology* / Q000601:surgery*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008568:Memory / Q000502:physiology*; D009483:Neuropsychological Tests / Q000592:standards*; D011184:Postoperative Period; D011237:Predictive Value of Tests; D013223:Statistics as Topic; D055815:Young Adult
D000654:Amobarbital