title: Chemical composition and antimicrobial activity of wild garlic Allium ursinum of Bulgarian origin.
abstract: The chemical composition of fresh flowers from Allium ursinum (ramsons, bear's garlic, wild garlic) growing in Bulgaria has been studied. Thymidine (1), adenosine (2), astragalin (kaempferol-3-O-beta-D-glucopyranoside (3), kaempferol-3-O-beta-D-glucopyranosyl-7-O-beta-D-glucopyranoside (4), kaempferol-3-O-beta-D-neohesperoside (5), and kaempferol-3-O-beta-D-neohesperoside-7-O-beta-D-glucopyranoside (6) were isolated from the n-butanol extract and identified by different spectroscopic and spectrometric methods. Thymine (7), uridine (8), uracil (9) and 5-chloro-uridine (10) were detected in the same extract by GC-MS. This is the first report of the occurrence of 1, 2, 4, 7 - 10 in the flowers of A. ursinum. GC-MS of the volatile components of fresh flowers and leaves from the same plant revealed a high content of sulfur compounds, some of which are reported for the first time for A. ursinum. The antimicrobial activities of extracts from fresh flowers and leaves of A. ursinum have been tested; some extracts exhibited moderate antifungal properties.
authors.affiliation: Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Sofia, Bulgaria. ivanova111@yahoo.com
authors.forename: Antoaneta
authors.initials: A
authors.lastname: Ivanova
authors.forename: Bozhanka
authors.initials: B
authors.lastname: Mikhova
authors.forename: Hristo
authors.initials: H
authors.lastname: Najdenski
authors.forename: Iva
authors.initials: I
authors.lastname: Tsvetkova
authors.forename: Ivanka
authors.initials: I
authors.lastname: Kostova
mesh_terms: D020001:1-Butanol; D000490:Allium / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology; D002031:Bulgaria; D002176:Candida albicans / Q000187:drug effects; D035264:Flowers / Q000737:chemistry; D005737:Garlic / Q000737:chemistry*; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D044949:Kaempferols / Q000302:isolation & purification / Q000494:pharmacology; D009822:Oils, Volatile / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification; D018515:Plant Leaves / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D044949:Kaempferols; D009822:Oils, Volatile; D010936:Plant Extracts; C006552:kaempferol; D020001:1-Butanol