Glutathione S-transferase M1 null genotype associated with gastric cancer among Asians.
OBJECTIVE
The Glutathione S-transferases (GSTs) play multiple roles in the pathogenesis and treatment of cancer. Studies investigating the association between Glutathione S-transferase M1 (GSTM1) null genotype and gastric cancer risk report conflicting results. The purpose of this study was to quantitatively summarize the evidence for such a relationship.


RESULTS
This meta-analysis included 35 studies, which included 4,505 gastric cancer cases and 9,062 controls. The combined results based on all studies showed that the GSTM1 null genotype was associated with an increased risk of gastric cancer (OR = 1.15, 95% confidence interval [CI] = 1.02, 1.29). When stratifying for race, results were similar among Asians (OR = 1.24, 95% CI = 1.07, 1.44) except Caucasians (OR = 1.04, 95% CI = 0.88, 1.24). When stratifying by the location, stage, Lauren's classification, histological differentiation, lymph node metastasis, smoking, and Helicobacter pylori infection of gastric cancer, we observed that patients with diffuse classification had a significantly higher frequency null genotype (OR = 4.80, 95% CI = 1.65,13.94) than those with intestinal classification among Caucasians.


CONCLUSIONS
This meta-analysis suggests that the GSTM1 null genotype may be associated with gastric cancer among Asians.
Wang
Hong
H
Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China. doctorwanghong@gmail.com
Zhou
Yong
Y
Zhuang
Wen
W
Yin
Yi-Qiong
YQ
Liu
Guan-Jian
GJ
Wu
Tai-Xiang
TX
Yao
Xun
X
Du
Liang
L
Wei
Mao-Ling
ML
Wu
Xiao-Ting
XT
D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D020022:Genetic Predisposition to Disease / Q000453:epidemiology*; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D015994:Incidence; D008297:Male; D012150:Polymorphism, Restriction Fragment Length; D011379:Prognosis; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013274:Stomach Neoplasms / Q000453:epidemiology* / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D015996:Survival Rate
D005982:Glutathione Transferase