Can aspirin protect or at least attenuate gentamicin ototoxicity in humans?
OBJECTIVE
To investigate and prove that Aspirin as an antioxidant protects, or at least attenuates Gentamicin ototoxicity in humans.


METHODS
A prospective, randomized, double-blind trial was conducted in 60 patients that completed all requirements. This study was conducted in the Department of Otolaryngology and Orthopedics, Besat Hospital, Hamadan University of Medical Sciences, Hamadan, Iran, between December 2007 and November 2008. The patients were divided into 2 groups, the experimental and the control groups that were similar with respect to gender, age, and weight. The treatment group received 1.5 g/day (500 mg every 8 hours) Aspirin, and the control group received placebo similar to the other group.


RESULTS
Comparison of the pure tone audiometry (PTA) at 1000 Hertz (Hz) (p=0.03), 2000 Hz (p=0.003), 4000 Hz (p=0.001), and 8000 Hz (p=0.0010) showed significant differences between mean of PTA at the beginning, 8th, and 15th day. The threshold of PTA at 250 Hz was significantly different only at the 8th and 15th day (p=0.004), also at the frequency of 500 Hz, the difference between the beginning within 15th day and 8th day with 15th day was significant (p=0.001).


CONCLUSIONS
In the present study, we had shown that Aspirin can protect the ototoxic effect of gentamicin in patients.
Behnoud
Fatholah
F
Department of Ear, Nose and Throat, Medical School, Hamadan University of Medical Sciences, Hamadan, Iran. behnoud344@yahoo.com
Davoudpur
Khashayar
K
Goodarzi
Mohammad T
MT
D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D001241:Aspirin / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D005839:Gentamicins / Q000009:adverse effects*; D034381:Hearing Loss / Q000139:chemically induced / Q000517:prevention & control*; D006801:Humans; D008297:Male; D011446:Prospective Studies
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D001241:Aspirin