Insulin with chondroitinase ABC treats the rat model of acute spinal cord injury.
Traumatic brain injury is often associated with acute spinal cord injury (ASCI). Insulin and chondroitinase ABC (ChABC) are both therapeutically effective, but the combined therapeutic effect of insulin and ChABC is still not clear. A combination of insulin and ChABC were used to treat a rat model of ASCI. This combination therapy prevented neuronal cell death by improving motor function, increasing cell growth and inhibiting cell apoptosis in ASCI rats. Expression of growth-associated protein 43, a marker of axonal re-growth, increased after combined treatment with insulin and ChABC. These results may provide a basis for a future method of treating ASCI.
Yang
Y-G
YG
Department of Orthopaedics, First Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Jiang
D-M
DM
Quan
Z-X
ZX
Ou
Y-S
YS
D000208:Acute Disease; D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D001369:Axons / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D049109:Cell Proliferation / Q000187:drug effects; D019765:Chondroitin ABC Lyase / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination; D004576:Electromyography; D005071:Evoked Potentials / Q000187:drug effects / Q000502:physiology; D005260:Female; D019922:GAP-43 Protein / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007328:Insulin / Q000627:therapeutic use*; D008297:Male; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D009431:Neural Conduction / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D020127:Recovery of Function; D013119:Spinal Cord Injuries / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology
D019922:GAP-43 Protein; D007004:Hypoglycemic Agents; D007328:Insulin; D019765:Chondroitin ABC Lyase