title: Renal dysfunction due to leukemic infiltration of kidneys in a case of chronic lymphocytic leukemia.
abstract: Renal failure due to leukemic infiltration of kidney in chronic lymphocytic leukemia is an extremely rare condition. The authors report a case of a 59-year-old white female, with a past medical history of chronic lymphocytic leukemia (CLL) with 2 years of evolution without medical therapy, admitted with nonoliguric acute renal failure needing dialysis. Renal biopsy showed extensive small lymphocytes' infiltration in the cortical interstitium by CLL cells. Cyclophosphamide and prednisolone were started and 1 month later changed to fludarabine plus cyclophosphamide with improvement of renal function. Although renal failure due to leukemic infiltration has been described in many cases of acute leukemia, only 11 cases of renal failure due to CLL cells' infiltration have been described in the literature. Renal histology is an extremely important tool to confirm diagnosis.
authors.affiliation: Department of Nephrology, Hospital of Curry Cabral, Lisbon, Portugal.
authors.forename: Ana Carina
authors.initials: AC
authors.lastname: Ferreira
authors.forename: Sandra
authors.initials: S
authors.lastname: Brum
authors.forename: Dulce
authors.initials: D
authors.lastname: Carvalho
authors.forename: Isabel
authors.initials: I
authors.lastname: Pataca
authors.forename: Fernanda
authors.initials: F
authors.lastname: Carvalho
authors.forename: Maria Céu
authors.initials: MC
authors.lastname: Santos
authors.forename: João Ribeiro
authors.initials: JR
authors.lastname: Santos
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007668:Kidney / Q000000981:diagnostic imaging / Q000473:pathology*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000188:drug therapy / Q000473:pathology*; D017254:Leukemic Infiltration / Q000188:drug therapy / Q000473:pathology*; D008875:Middle Aged; D011239:Prednisolone / Q000008:administration & dosage; D006435:Renal Dialysis / Q000379:methods; D051437:Renal Insufficiency / Q000473:pathology; D014463:Ultrasonography; D014740:Vidarabine / Q000008:administration & dosage / Q000031:analogs & derivatives
chemical_list: D003520:Cyclophosphamide; D011239:Prednisolone; D014740:Vidarabine; C024352:fludarabine