title: Enhancement of anti-tumor immunity by photodynamic therapy.
abstract: Photodynamic therapy (PDT) is an FDA-approved modality that rapidly eliminates local tumors, resulting in cure of early disease and palliation of advanced disease. PDT was originally considered to be a local treatment; however, both pre-clinical and clinical studies have shown that local PDT treatment of tumors can enhance systemic anti-tumor immunity. The current state of investigations into the ability of PDT to enhance anti-tumor immunity, the mechanisms behind this enhancement and the future of PDT as an immunotherapy are addressed in this review.
authors.affiliation: Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA. Sandra.gollnick@roswellpark.org
authors.forename: Sandra O
authors.initials: SO
authors.lastname: Gollnick
authors.forename: Craig M
authors.initials: CM
authors.lastname: Brackett
mesh_terms: D000818:Animals; D019496:Cancer Vaccines / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects / Q000276:immunology; D009369:Neoplasms / Q000188:drug therapy* / Q000276:immunology*; D010778:Photochemotherapy
chemical_list: D019496:Cancer Vaccines