Development of new DNA triplex triads by using 5-substituted deoxycytidine.
We developed a new artificial DNA triplex triad which has the adenine nucleobase in the first strand. This triplex triad (A-psi-C*) is composed of adenine, pseudouridine and 5-sudstituted cytosine as the 1st, 2nd and 3rd strand nucleobases, respectively. The molecular design and synthesis of the nucleobases for the 2nd and 3rd strand of the triplex are also described.
Kanamori
Takashi
T
Department of Life Science, Tokyo Institute of Technology, Yokohama 226-8501, Japan.
Tsunoda
Hirosuke
H
Ohkubo
Akihiro
A
Sekine
Mitsuo
M
Seio
Kohji
K
D004247:DNA / Q000737:chemistry*; D003841:Deoxycytidine / Q000737:chemistry*; D009691:Nucleic Acid Denaturation
C051802:triplex DNA; D003841:Deoxycytidine; D004247:DNA