In vitro activity of daptomycin against Staphylococcus aureus and vancomycin-resistant Enterococcus faecium isolates associated with skin and soft tissue infections: first results from India.
The in vitro activity of daptomycin and selected comparator agents against Staphylococcus aureus and vancomycin-resistant Enterococcus faecium (VREF) isolates recovered from hospitalized patients with skin and soft tissue infection's was evaluated by Clinical and Laboratory Standards Institute broth microdilution method. Daptomycin was the most active agent against both S. aureus (MIC(90), 1 microg/mL; 100% susceptible) and VREF (MIC(90), 4 microg/mL; 100% susceptible), making it an excellent therapeutic option.
Dhawan
Benu
B
Department of Microbiology, All India Institute of Medical Sciences, New Delhi-29, India. dhawanb@gmail.com
Gadepalli
Ravisekhar
R
Kapil
Arti
A
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D017576:Daptomycin / Q000494:pharmacology*; D016984:Enterococcus faecium / Q000187:drug effects* / Q000302:isolation & purification; D006760:Hospitalization; D006801:Humans; D007194:India; D008826:Microbial Sensitivity Tests; D017192:Skin Diseases, Bacterial / Q000382:microbiology*; D018461:Soft Tissue Infections / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000302:isolation & purification; D020713:Vancomycin Resistance
D000900:Anti-Bacterial Agents; D017576:Daptomycin