Normal morphology and hormone receptor expression in the male California sea lion (Zalophus californianus) genital tract.
Histomorphology and estrogen alpha (ER alpha), and progesterone receptor (PR) expression were evaluated in free-ranging stranded male California sea lions (Zalophus californianus). Hormone receptor expression was evaluated using an immunohistochemical technique with monoclonal antibodies. Estrogen and PRs were identified in the efferent ductules, prostate gland, corpus cavernosa, corpus spongiosium, penile urethra, and in the epithelium and stroma of both the penis and prepuce. In some tissues, ER alpha expression was more intense in the stroma, emphasizing the importance of the stroma in hormone-mediated growth and differentiation of reproductive organs. To our knowledge, this is the first study to localize ER alpha and PR to the epithelium of the glans penis. The results of this investigation add to the general knowledge of male California sea lion reproduction and suggest that estrogens could have a role in the function of the male reproductive tract.
Colegrove
Kathleen M
KM
Department of Pathology, University of California, Davis, CA, USA. kcolegrove@lumc.edu
Gulland
Frances M D
FM
Naydan
Diane K
DK
Lowenstine
Linda J
LJ
D000818:Animals; D004967:Estrogens / Q000378:metabolism; D005837:Genitalia, Male / Q000033:anatomy & histology* / Q000378:metabolism; D012739:Gonadal Steroid Hormones / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D010413:Penis / Q000166:cytology / Q000378:metabolism; D011374:Progesterone / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism*; D011980:Receptors, Progesterone / Q000378:metabolism*; D046070:Sea Lions / Q000033:anatomy & histology* / Q000502:physiology; D012733:Sex Differentiation / Q000502:physiology
D004967:Estrogens; D012739:Gonadal Steroid Hormones; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D011374:Progesterone