Canary Prostate Active Surveillance Study: design of a multi-institutional active surveillance cohort and biorepository.
Active surveillance is a management plan for localized prostate cancer that offers selective delayed intervention on indication of disease progression, allowing patients to delay or avoid treatment and associated side-effects. Outcomes from centers that promote active surveillance are favorable, with high rates of disease-specific survival. However, there remains a need for prognostic variables or biomarkers that distinguish with high specificity the aggressive cancers that progress on surveillance from the indolent cancers. The Canary Prostate Active Surveillance Study is a multicenter study and a biorepository that will discover and confirm biomarkers of aggressive disease as defined by histologic, prostate-specific antigen, or clinical criteria.
Newcomb
Lisa F
LF
Department of Urology, University of Washington, Seattle, Washington 98195, USA.
Brooks
James D
JD
Carroll
Peter R
PR
Feng
Ziding
Z
Gleave
Martin E
ME
Nelson
Peter S
PS
Thompson
Ian M
IM
Lin
Daniel W
DW
D018070:Biological Specimen Banks; D015415:Biomarkers; D006801:Humans; D008297:Male; D015337:Multicenter Studies as Topic; D011159:Population Surveillance; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000097:blood / Q000628:therapy*
D015415:Biomarkers; D017430:Prostate-Specific Antigen