[Side effects of opioid and gene variants].
There are individual differences in the analgesic effect and the side effect of the opioid to which genetic variation may be related. Analysis of micro-opioid receptor knockout mice indicated that inhibition of gastrointestinal transit by morphine is mediated by micro-opioid receptor. Our study suggested that gastrointestinal symptom (especially loss of appetite) as a side effect of opioid could be associated with the gene polymorphism of dopamine D2 receptor. Understanding of the relationships between gene polymorphisms and opioid sensitivities may lead to more-accurate prediction of the opioid sensitivity and opioid requirements in individual patients.
Sora
Ichiro
I
Department of Biological Psychiatry, Tohoku University Graduate School of Medicine, Sendai 980-8575.
Komatsu
Hiroshi
H
Igari
Moe
M
Ide
Soichiro
S
Ikeda
Kazutaka
K
Shimoyama
Naoto
N
D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics; D000818:Animals; D003248:Constipation / Q000139:chemically induced / Q000235:genetics; D005772:Gastrointestinal Transit / Q000187:drug effects / Q000235:genetics; D006801:Humans; D007206:Individuality; D051379:Mice; D009325:Nausea / Q000139:chemically induced / Q000235:genetics; D010597:Pharmacogenetics; D011110:Polymorphism, Genetic; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D017450:Receptors, Opioid, mu / Q000235:genetics*
D000701:Analgesics, Opioid; D017448:Receptors, Dopamine D2; D017450:Receptors, Opioid, mu