Cassiarins C-E, antiplasmodial alkaloids from the flowers of Cassia siamea.
Three new alkaloids, cassiarins C-E (1-3), and a new chromone, 10,11-dihydroanhydrobarakol (4), which showed moderate antiplasmodial activity against Plasmodium falciparum 3D7, were isolated from flowers of Cassia siamea, and the structures of 1-4 were elucidated by 2D NMR analysis and chemical transformation. Cassiarin D (2) was a dimeric compound consisting of 5-acetonyl-7-hydroxy-2-methylchromone and cassiarin C (1), and cassiarin E (3) was a dimer of cassiarins A and C (1).
Oshimi
Shiori
S
Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa, Tokyo 142-8501, Japan.
Deguchi
Jun
J
Hirasawa
Yusuke
Y
Ekasari
Wiwied
W
Widyawaruyanti
Aty
A
Wahyuni
Tutik Sri
TS
Zaini
Noor Cholies
NC
Shirota
Osamu
O
Morita
Hiroshi
H
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002366:Cassia / Q000737:chemistry*; D035264:Flowers / Q000737:chemistry; D006575:Heterocyclic Compounds, 3-Ring / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D007214:Indonesia; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D021261:Parasitic Sensitivity Tests; D010963:Plasmodium falciparum / Q000187:drug effects*
D000470:Alkaloids; D000962:Antimalarials; D006575:Heterocyclic Compounds, 3-Ring; C545128:cassiarin C; C545129:cassiarin D; C545130:cassiarin E