Making sense of antisense in antibiotic drug discovery.
In an era of increasing antibiotic resistance, growing clinical need for new drugs, and few lead molecules, new research is helping to identify new targets and the mechanism of action of lead molecules.
Wright
Gerard D
GD
M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, ON, Canada. wrightge@mcmaster.ca
D000900:Anti-Bacterial Agents / Q000737:chemistry*; D001419:Bacteria / Q000201:enzymology* / Q000235:genetics; D001426:Bacterial Proteins / Q000037:antagonists & inhibitors* / Q000235:genetics; D015195:Drug Design; D016372:RNA, Antisense / Q000235:genetics*
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D016372:RNA, Antisense