title: [Absorption kinetics of atractylenolide I in intestines of rats].
abstract: OBJECTIVE
  To investigate the absorption kinetics of atractylenolide I in intestines of rats and the influence of P-glycoprotein (P-gp) on the absorption.
  
  
  METHODS
  The absorption kinetics was investigated using the method of in situ intestine absorption in rats and the samples were determined by HPLC.
  
  
  RESULTS
  Atractylenolide I is absorbed quite well at all segments of intestine in rats and no specific absorption was founded in different segment. When the concentration of perfusion solution was increased contrarily the absorption rate constant (Ka) kept at the same level. Compared Ka of three different concentration of perfusion solution with variance analysis method, Ka of atractylenolide I had no significant differences. But the Ka values were significently increased in the presence of P-gp inbibitor, verapamil or digoxin.
  
  
  CONCLUSIONS
  Atractylenolide I can be classified into high penetrating drug. Passive diffusion dominates the absorptive transport behivior of atractylenolide I. Atractylenolide I can be absorbed in the whole intestinal segments and there is not a preferntial absorption zone in the intestine. The absorption and secretion of atractylenolide I are mediated by the efflux transport system, P-gp.
authors.affiliation: School of Medicine, Xi'an Jiaotong University, Xi'an 710061, China.
authors.forename: Changhe
authors.initials: C
authors.lastname: Wang
authors.forename: Haijie
authors.initials: H
authors.lastname: Duan
authors.forename: Langchong
authors.initials: L
authors.lastname: He
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000378:metabolism; D000818:Animals; D007408:Intestinal Absorption / Q000187:drug effects*; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000737:chemistry* / Q000187:drug effects; D007700:Kinetics; D007783:Lactones / Q000493:pharmacokinetics*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012717:Sesquiterpenes / Q000493:pharmacokinetics*
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D007783:Lactones; D012717:Sesquiterpenes; C424804:atractylenolide I