Aaptamine alkaloids from the Vietnamese sponge Aaptos sp.
A series of aaptamines, including one new alkaloid (1), were isolated from the marine sponge Aaptos sp. collected in Vietnamese waters. The structure of 1 was elucidated using NMR and HRESIMS, as well as by chemical transformation of 1 to the previously known aaptamine and established as 3-N-morpholinyl-9-demethyl(oxy)aaptamine. The isolated compounds showed a potential cancer preventive activity.
Shubina
Larisa K
LK
Laboratory of Chemistry MaNaPro, Pacific Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Vladivostok, Russia. shubina@piboc.dvo.ru
Kalinovsky
Anatoly I
AI
Fedorov
Sergey N
SN
Radchenko
Oleg S
OS
Denisenko
Vladimir A
VA
Dmitrenok
Pavel S
PS
Dyshlovoy
Sergey A
SA
Krasokhin
Vladimir B
VB
Stonik
Valentin A
VA
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification*; D000818:Animals; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008958:Models, Molecular; D009287:Naphthyridines / Q000737:chemistry / Q000302:isolation & purification*; D011161:Porifera / Q000737:chemistry*; D012623:Seawater; D014744:Vietnam
D000470:Alkaloids; D009287:Naphthyridines; C043986:aaptamine