title: Modeling upper airway collapse by a finite element model with regional tissue properties.
abstract: This study presents a new computational system for modeling the upper airway in rats that combines tagged magnetic resonance imaging (MRI) with tissue material properties to predict three-dimensional (3D) airway motion. The model is capable of predicting airway wall and tissue deformation under airway pressure loading up to airway collapse. The model demonstrates that oropharynx collapse pressure depends primarily on ventral wall (tongue muscle) elastic modulus and airway architecture. An iterative approach that involves substituting alternative possible tissue elastic moduli was used to improve model precision. The proposed 3D model accounts for stress-strain relationships in the complex upper airway that should present new opportunities for understanding pathogenesis of airway collapse, improving diagnosis and developing treatments.
authors.affiliation: Department of Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA. xuc@uphs.upenn.edu
authors.forename: Chun
authors.initials: C
authors.lastname: Xu
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Brennick
authors.forename: Lawrence
authors.initials: L
authors.lastname: Dougherty
authors.forename: David M
authors.initials: DM
authors.lastname: Wootton
mesh_terms: D000402:Airway Obstruction / Q000503:physiopathology*; D000818:Animals; D003198:Computer Simulation; D004548:Elasticity; D020342:Finite Element Analysis; D006801:Humans; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging / Q000379:methods; D008953:Models, Anatomic; D010614:Pharynx / Q000503:physiopathology*; D051381:Rats; D015656:Respiratory Mechanics; D012132:Respiratory Muscles; D014132:Trachea / Q000473:pathology*; D016474:Weight-Bearing / Q000502:physiology