Analysis of CXCL9 and CXCR3 expression in a case of intravascular large B-cell lymphoma.
Intravascular large B-cell lymphoma is a rare disease with multiorgan involvement that also affects the skin. Skin manifestations include purpuric to red macules, plaques, or nodules with occasional edema and tenderness. We report a 68-year-old woman with bilateral leg edema and occasional high fever. A biopsy specimen from a subcutaneous nodule showed that the blood vessels in the dermis and subcutaneous tissue were filled with irregularly shaped chromatin-rich large atypical lymphocytes positive for CD20 and bcl-2, consistent with the diagnosis of intravascular large B-cell lymphoma. In addition, immunohistochemical analysis showed expression of CXCR3 in the atypical lymphocytes; its ligand, CXCL9, was detected in blood vessels. Although limited to a single case, our study could provide a possible new clue to the pathogenesis of intravascular large B-cell lymphoma by virtue of the characteristic expression of CXCL9-CXCR3.
Kato
Maymi
M
Division of Dermatology, Mitsubishi Hospital, Kyoto, Japan.
Ohshima
Koichi
K
Mizuno
Masahiro
M
Kyogoku
Masahisa
M
Hashikawa
Keiko
K
Tokura
Yoshiki
Y
Miyachi
Yoshiki
Y
Kabashima
Kenji
K
D000368:Aged; D001706:Biopsy; D054370:Chemokine CXCL9 / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D016403:Lymphoma, Large B-Cell, Diffuse / Q000276:immunology / Q000378:metabolism* / Q000473:pathology*; D054367:Receptors, CXCR3 / Q000378:metabolism*; D012867:Skin / Q000098:blood supply; D019043:Vascular Neoplasms / Q000276:immunology / Q000378:metabolism* / Q000473:pathology*
C080810:CXCL9 protein, human; C515187:CXCR3 protein, human; D054370:Chemokine CXCL9; D054367:Receptors, CXCR3