Superficial siderosis of the central nervous  system - treatment with steroids?
Steroids have been suggested as a therapeutic option for superficial siderosis of the central nervous system (SSCNS) without identifiable bleeding source. Longitudinal observational data of a patient with idiopathic SSCNS who was repeatedly treated with methylprednisolone over a course of 2 years are reported. The case history is critically discussed on the background of the sparse literature. In conclusion, if at all, there is only a limited and temporary, mostly subjective clinical response to steroids in SSCNS. Systematic studies of this medication in SSCNS do not seem warranted. Pathophysiological considerations hopefully may lead to more helpful medications for this chronic and debilitating disorder.
Scheid
R
R
Day Clinic of Cognitive Neurology, University of Leipzig, Leipzig, Germany. scheid@cbs.mpg.de
Frisch
S
S
Schroeter
M L
ML
D002493:Central Nervous System Diseases / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use*; D008875:Middle Aged; D012806:Siderosis / Q000175:diagnosis / Q000188:drug therapy*
D008775:Methylprednisolone