Influence of three different colloidal systems on the oxytetracycline-lecithin behavior.
Oxytetracycline (OTC) is a wide spectrum antibiotic, but it is known to be degradated when it is stored under adverse conditions. It is classified as short-acting based on serum half-lives of 6-8 h. The stabilizing effect of colloidal carrier systems and their ability to sustain drug release for OTC was investigated using solid dispersion, liposomes and solid lipid nanoparticles with lecithin. Analysis of chemical stability showed that OTC is more resistant in colloid systems than in the free form. The characterization results show clear differences between the prepared systems. Release studies show that a sustained release is achieved when the OTC is formulated in these carriers.
Faustino-Vega
A
A
Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, México, DF.
Alvarez-Polo
M A
MA
Gasca
B
B
Bernad-Bernad
M J
MJ
D000900:Anti-Bacterial Agents / Q000737:chemistry*; D003102:Colloids; D004337:Drug Carriers; D004339:Drug Compounding; D004355:Drug Stability; D004356:Drug Storage; D004563:Electrochemistry; D054709:Lecithins / Q000737:chemistry*; D008081:Liposomes; D008855:Microscopy, Electron, Scanning; D010118:Oxytetracycline / Q000737:chemistry*; D010316:Particle Size; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet
D000900:Anti-Bacterial Agents; D003102:Colloids; D004337:Drug Carriers; D054709:Lecithins; D008081:Liposomes; D010118:Oxytetracycline