title: [Preparation and prescription of enteric coated pellets of Panax notoginseng saponins pellets].
abstract: OBJECTIVE
  To prepare enteric coated pellets containing panax notoginseng saponins.
  
  
  METHODS
  Panax notoginseng saponins loaded pellets were prepared by Extrusion-Spheronization method, and coated by Eudragit L30D-55 using Glatt fluid bed with the bottom spray process, central composite design was used to optimize the coating prescription.
  
  
  RESULTS
  The drug release of enteric coated pellets of panax notoginseng saponins pellets would be lower than 5% in 2 h in simulated gastric fluid, but reach above 85% in 3 h in simulated human gastroenteric environment.
  
  
  CONCLUSIONS
  The enteric coated pellets of panax notoginseng saponins have good acid residence to avoid panax notoginseng saponins from degrading in gastric acid.
authors.affiliation: Key Laboratory of Modern Preparation of Jiangxi University of Traditional Chinese Medicine, Ministry of Education, Nanchang 330004, China. chunhualai1985@163.com
authors.forename: Chunhua
authors.initials: C
authors.lastname: Lai
authors.forename: Qin
authors.initials: Q
authors.lastname: Zheng
authors.forename: Ming
authors.initials: M
authors.lastname: Yang
authors.forename: Pengyi
authors.initials: P
authors.lastname: Hu
authors.forename: Junjie
authors.initials: J
authors.lastname: Pan
authors.forename: Changchun
authors.initials: C
authors.lastname: Peng
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000379:methods*; D004355:Drug Stability; D005744:Gastric Acid / Q000737:chemistry; D041981:Gastrointestinal Tract / Q000187:drug effects; D006801:Humans; D008954:Models, Biological; D053723:Panax notoginseng / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry* / Q000493:pharmacokinetics; D013608:Tablets, Enteric-Coated / Q000737:chemistry
chemical_list: D012503:Saponins; D013608:Tablets, Enteric-Coated