title: Influence of previous tumours on survival in early (Tis-T1) glottic carcinoma.
abstract: OBJECTIVE
  To investigate the influence of previous tumours on overall survival in patients with early glottic carcinoma.
  
  
  METHODS
  Retrospective, population-based cohort study.
  
  
  METHODS
  Cancer registration area in the west Netherlands.
  
  
  METHODS
  Population-based data on previous and subsequent tumours in patients diagnosed with early glottic carcinoma (Tis and T1) in the west Netherlands between 1982 and 1993 were collected from charts and cancer registries. The impact of previous tumours on survival was tested in multivariate analysis.
  
  
  METHODS
  Overall survival.
  
  
  RESULTS
  Of 359 patients, 22 patients (6%) had a total of 23 previous tumours. Previous tumours had an independent impact on overall survival (hazard ratio 3.4, p < or = .001). Other determinants of survival were age and subsequent tumours. Nonmalignant comorbidity was of borderline significance.
  
  
  CONCLUSIONS
  Previous tumors have an impact on survival in patients with early glottic carcinoma and should be considered as an additional factor in counseling and prognostication.
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, Leiden University Medical Center, Leiden, The Netherlands.
authors.forename: Elisabeth V
authors.initials: EV
authors.lastname: Sjögren
authors.forename: Simone
authors.initials: S
authors.lastname: Snijder
authors.forename: Saskia
authors.initials: S
authors.lastname: Le Cessie
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Baatenburg de Jong
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D005260:Female; D005931:Glottis; D006801:Humans; D007822:Laryngeal Neoplasms / Q000150:complications / Q000401:mortality* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000150:complications*; D009426:Netherlands; D012042:Registries; D012189:Retrospective Studies; D016019:Survival Analysis