Synthesis and cytotoxic evaluation of 6-(3-pyrazolylpropyl) derivatives of 1,4-naphthohydroquinone-1,4-diacetate.
Several new 6-(3-pyrazolylpropyl) derivatives of 1,4-naphthohydroquinone-1,4-diacetate (NHQ-DA) have been prepared by chemical modifications of the Diels-Alder adduct of alpha-myrcene and 1,4-benzoquinone. All these new compounds and precursors have been evaluated in vitro for their cytotoxicity against cultured human cancer cells of MB-231 breast-adeno carcinoma, A-549 lung carcinoma, and HT-29 colon carcinoma. GI(50) values ranged in and below the micromolar concentration level.
Molinari
Aurora
A
Instituto de Química, Facultad de Ciencias Bsicas y Matemticas, Pontificia Universidad Católica de Valparaíso, Valparaiso, Chile. amolinar@ucv.cl
Oliva
Alfonso
A
Ojeda
Claudia
C
del Corral
José M Miguel
JM
Castro
M Angeles
MA
Cuevas
Carmen
C
San Feliciano
Arturo
A
D000085:Acetates / Q000138:chemical synthesis / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D019073:HT29 Cells; D006801:Humans; D006873:Hydroquinones / Q000138:chemical synthesis / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D013329:Structure-Activity Relationship
D000085:Acetates; D000970:Antineoplastic Agents; D006873:Hydroquinones; C063601:1,4-naphthohydroquinone