title: Sevelamer reduces the efficacy of many other drugs.
abstract: (1) Sevelamer, a phosphate-binding polymer, is used to treat hyperphosphataemia in patients with chronic renal failure. Pharmacokinetic studies and some clinical reports have shown that sevelamer binds many drugs, including furosemide, ciclosporin and tacrolimus, thus making them less effective; (2) It is best to take sevelamer some time before or after other drugs.
mesh_terms: D001002:Anuria / Q000139:chemically induced; D002614:Chelating Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use; D002784:Cholesterol / Q000378:metabolism; D004347:Drug Interactions; D005665:Furosemide / Q000037:antagonists & inhibitors; D006801:Humans; D054559:Hyperphosphatemia / Q000188:drug therapy; D007676:Kidney Failure, Chronic / Q000188:drug therapy; D009853:Omeprazole; D011073:Polyamines / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics / Q000627:therapeutic use; D006435:Renal Dialysis / Q000009:adverse effects; D000069603:Sevelamer; D014815:Vitamins / Q000037:antagonists & inhibitors
chemical_list: D002614:Chelating Agents; D011073:Polyamines; D014815:Vitamins; D005665:Furosemide; D002784:Cholesterol; D000069603:Sevelamer; D009853:Omeprazole