Lipid peroxidation and antioxidants in different stages of cervical cancer: Prognostic significance.
BACKGROUND
Free radical Injury is associated with cancer, but how the extent of oxidative stress correlates with the FIGO (International Federation of Gynecology and Obstetrics) stage in Carcinoma Cervix (Ca Cx), and its significance as a prognostic marker, is not clear and needs an in-depth study.


OBJECTIVE
To correlate the blood levels of Lipid Peroxidation (LPO), Reduced Glutathione (GSH), Superoxide Dismutase (SOD), and Vitamin A and E levels with the clinical stage in Ca Cx.


METHODS
This is a Prospective Case Control Study.


METHODS
LPO, SOD, reduced GSH were estimated by Bio Chemical Assays and Vitamins by High Performance Liquid Chromatography (HPLC).


METHODS
The cases and controls were compared using One Way ANOVA and different stages over different time periods were individually compared by Repeated Measure Analysis of Variance.


RESULTS
The results indicated a statistically significant increase of LPO vis-a-vis the FIGO stage of Ca Cx and control, while the antioxidant status as depicted by GSH and SOD decreased. Vitamin A and E levels were significantly lower in cancer cases as compared to the control.


CONCLUSIONS
Increased LPO and reduced antioxidant levels may be taken as associated predictive markers, thus suggesting that Ca Cx cases should get nutritive supplements to contain the blood LPO level and maintain a positive balance of antioxidants for a better outcome in terms of delayed recurrence and better Quality of Life (QOL).
Srivastava
S
S
Department of Pathology, Lucknow University, India.
Natu
S M
SM
Gupta
A
A
Pal
K A
KA
Singh
U
U
Agarwal
G G
GG
Singh
Uma
U
Goel
M M
MM
Srivastava
A N
AN
D000975:Antioxidants / Q000032:analysis*; D005260:Female; D005978:Glutathione / Q000097:blood; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology*; D009367:Neoplasm Staging; D018384:Oxidative Stress / Q000502:physiology; D011379:Prognosis; D013482:Superoxide Dismutase / Q000097:blood; D002583:Uterine Cervical Neoplasms / Q000097:blood* / Q000473:pathology*; D014801:Vitamin A / Q000097:blood; D014810:Vitamin E / Q000097:blood
D000975:Antioxidants; D014801:Vitamin A; D014810:Vitamin E; D013482:Superoxide Dismutase; D005978:Glutathione