title: Association of serum amyloid A levels with adipocyte size and serum levels of adipokines: differences between men and women.
abstract: The aim of this study was to characterize the association between adipocyte enlargement and circulating levels of serum amyloid A (SAA). Furthermore, we wanted to search for possible associations with measures of glycemic control and levels of circulating adipokines and/or inflammatory markers in men and women with a large range in body mass index. The study cohort consisted of 167 subjects, 114 non-diabetic and 53 with Type 2 diabetes. Adipocyte diameter as well as circulating levels of SAA, C-reactive protein (CRP), adiponectin, leptin, interleukin-6, tumor necrosis factor alpha, glucose and insulin were measured. Women had higher serum levels of SAA than men (p=0.044). SAA levels were weakly but positively correlated with BMI (p=0.043) and % body fat (p=0.027) in all subjects as well as subcutaneous adipocyte diameter (p=0.034) in women. Furthermore, in all subjects we found correlations between SAA levels and levels of CRP (p<0.001), interleukin-6 (p<0.001), leptin (p=0.003), insulin (p=0.006), HbA1c (p=0.02) and HOMA-IR (p=0.002). A majority of the correlations were strongest in women. In conclusion, serum levels of SAA are strongly correlated with serum levels of inflammatory markers as well as measures of glycemic control. There seems to be large sex differences in these associations suggesting that sex-specific factors need to be considered when analyzing SAA levels in relation to metabolic disease.
authors.affiliation: Sahlgrenska Center for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, Institute of Medicine, The Sahlgrenska Academy, Göteborg University, Göteborg, Sweden. kajsa.sjoholm@medic.gu.se
authors.forename: Kajsa
authors.initials: K
authors.lastname: Sjöholm
authors.forename: Magdalena
authors.initials: M
authors.lastname: Lundgren
authors.forename: Maja
authors.initials: M
authors.lastname: Olsson
authors.forename: Jan W
authors.initials: JW
authors.lastname: Eriksson
mesh_terms: D017667:Adipocytes / Q000166:cytology / Q000276:immunology; D054392:Adipokines / Q000097:blood*; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D048429:Cell Size; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000378:metabolism; D000685:Serum Amyloid A Protein / Q000378:metabolism; D012737:Sex Factors
chemical_list: D054392:Adipokines; D000685:Serum Amyloid A Protein; D002097:C-Reactive Protein