title: Use of tylvalosin-medicated feed to control porcine proliferative enteropathy.
abstract: The effect of an oral treatment with the tartrate salt of tylvalosin on the development of proliferative enteropathy in 60 experimentally challenged pigs was studied. Thirty of the pigs were fed a diet medicated with 50 ppm tylvalosin and 30 were fed the unmedicated diet. The treated animals started to receive the medicated feed the day before they were inoculated, and continued to receive it for 14 days. The pigs' bodyweight, feed consumption and clinical signs were evaluated, and they were examined postmortem 20 days after inoculation, and samples of ileum were collected for immunohistochemistry (IHC) for Lawsonia intracellularis. Clinical signs of the disease were more evident in the untreated group than in the treated group. The average daily weight gain, average daily feed consumption and feed conversion efficiency were better in the treated group. The combined length of intestine with lesions was 2847 cm in the untreated group and 183 cm in the treated group. The tylvalosin treatment significantly reduced the level of L intracellularis infection; almost half of the treated pigs were IHC-negative compared with 3.3 per cent of the untreated pigs.
authors.affiliation: Department of Clinic and Surgery, Veterinary School, Federal University of Minas Gerais, Belo Horizonte, MG 31 270-901, Brazil. guedes@vet.ufmg.br
authors.forename: R M C
authors.initials: RM
authors.lastname: Guedes
authors.forename: S A
authors.initials: SA
authors.lastname: França
authors.forename: G S
authors.initials: GS
authors.lastname: Machado
authors.forename: M A
authors.initials: MA
authors.lastname: Blumer
authors.forename: E C
authors.initials: EC
authors.lastname: da Costa Cruz
mesh_terms: D000821:Animal Feed; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000627:therapeutic use*; D045824:Desulfovibrionaceae Infections / Q000517:prevention & control / Q000662:veterinary*; D007079:Ileitis / Q000517:prevention & control / Q000662:veterinary*; D013552:Swine; D013553:Swine Diseases / Q000382:microbiology / Q000517:prevention & control*; D013997:Time Factors; D015645:Tylosin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; C545430:tylvalosin; D015645:Tylosin