title: Primary central nervous system lymphoma.
abstract: OBJECTIVE
  This review will summarize recent advances in the understanding and treatment of primary central nervous system lymphoma (PCNSL).
  
  
  RESULTS
  The molecular and genetic characteristics that distinguish PCNSL are beginning to be elucidated. New tools such as flow cytometry and PET are improving the diagnosis and management of PCNSL. Although the current standard of care is high-dose methotrexate-based chemotherapy alone or in combination with whole brain radiotherapy, multiple questions remain regarding the optimal treatment of PCNSL, in general, and unusual variants of PCNSL.
  
  
  CONCLUSIONS
  Although recent advances have improved our understanding of PCNSL, the need for additional collaborative research is critical.
authors.affiliation: Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA. abreyl@mskcc.org
authors.forename: Lauren E
authors.initials: LE
authors.lastname: Abrey
mesh_terms: D016543:Central Nervous System Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics / Q000628:therapy; D003131:Combined Modality Therapy; D006801:Humans; D008223:Lymphoma / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics / Q000628:therapy; D049268:Positron-Emission Tomography