title: The stem cell--chromatin connection.
abstract: Stem cells self-renew and give rise to all differentiated cell types of the adult body. They are classified as toti-, pluri- or multi-potent based on the number of different cell types they can give rise to. Recently it has become apparent that chromatin regulation plays a critical role in determining the fate of stem cells and their descendants. In this review we will discuss the role of chromatin regulators in maintenance of stem cells and their ability to give rise to differentiating cells in both the animal and plant kingdom. We will highlight similarities and differences in chromatin-mediated control of stem cell fate in plants and animals. We will consider possible reasons why chromatin regulators play a central role in pluripotency in both kingdoms given that multicellularity evolved independently in each.
authors.affiliation: Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, United States.
authors.forename: Yi
authors.initials: Y
authors.lastname: Sang
authors.forename: Miin-Feng
authors.initials: MF
authors.lastname: Wu
authors.forename: Doris
authors.initials: D
authors.lastname: Wagner
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D019070:Cell Lineage; D002843:Chromatin / Q000737:chemistry / Q000378:metabolism*; D019175:DNA Methylation; D018507:Gene Expression Regulation, Developmental; D006657:Histones / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D010944:Plants / Q000378:metabolism; D013234:Stem Cells / Q000166:cytology*
chemical_list: D002843:Chromatin; D006657:Histones