title: Chemical methods to study protein-nucleic acid interactions.
abstract: Accumulation of genetic changes due to the presence of unrepaired DNA lesions can lead to cancer development and other diseases. Nucleic acid modifications also play key roles in many essential life processes. We have developed a series of chemically modified nucleic acid analogues that can be applied to stabilize protein-nucleic acid interactions for structural and proteomic studies. Some of the probes have also been employed to study nucleic acid-nucleic acid interactions.
authors.affiliation: Department of Chemistry, The University of Chicago, Chicago, Illinois 60637, USA. chuanhe@uchicago.edu
authors.forename: Chuan
authors.initials: C
authors.lastname: He
mesh_terms: D000071499:AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase; D003432:Cross-Linking Reagents; D004249:DNA Damage; D004260:DNA Repair; D045643:DNA Repair Enzymes / Q000737:chemistry*; D049308:Dioxygenases / Q000737:chemistry*; D008958:Models, Molecular
chemical_list: D003432:Cross-Linking Reagents; D049308:Dioxygenases; C486440:ALKBH2 protein, human; D000071499:AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase; D045643:DNA Repair Enzymes