Potential link of microalbuminuria with metabolic syndrome in patients undergoing coronary angiography.
OBJECTIVE
Microalbuminuria and metabolic syndrome (MetS) are both risk factors for cardiovascular disease.We sought to examine the relationship between microalbuminuria and MetS in patients undergoing coronary angiography.


METHODS
From August 2007 to March 2008, we studied 531 patients (354 men, 66.7%) undergoing elective coronary angiography due to symptoms related to coronary artery disease. MetS was defined based on the adapted Adult Treatment Panel III (ATP-III A) proposed by the American Heart Association/National Heart, Lung, and Blood Institute, and microalbuminuria was defined as urinary albumin-to-creatinine ratio (ACR) between 30 mg/g and 300 mg/g.


RESULTS
MetS was detected in 39.7% of participants, 62.1% of women and 28.5% of men. Microalbuminuria was detected in 109 (20.5%) of participants, in 41 (12.8%) of non-MetS individuals, and in 68 (32.2%) of the MetS individuals. There was a significant positive association between the number of components of MetS and the corresponding prevalence of microalbuminuria (p<0.001). In patients with MetS compared to those without any component of MetS, multivariable-adjusted OR (95% CI) of microalbuminuria was 2.71 (1.71-4.29). Multiple logistic regression analyses revealed higher fasting blood glucose and lower HDL-cholesterol are independently associated with microalbuminuria.


CONCLUSIONS
Our study demonstrated that microalbuminuria is strongly associated with MetS and that among the components of MetS high fasting blood glucose had the largest power to determine the risk of microalbuminuria in Iranian patients undergoing coronary angiography.
Anvari
Maryam Sotoudeh
MS
Department of Surgical and Clinical Pathology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.
Boroumand
Mohammad Ali
MA
Pourgholi
Leila
L
Sheikhfathollahi
Mahmood
M
Rouhzendeh
Mahmoud
M
Rabbani
Shahram
S
Goodarzynejad
Hamidreza
H
D000368:Aged; D000419:Albuminuria / Q000150:complications / Q000453:epidemiology*; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000209:etiology*; D005260:Female; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007492:Iran / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications / Q000453:epidemiology*; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors
D005947:Glucose