title: Antioxidant, anti-inflammatory and analgesic potential of the Citrus decumana L. peel extract.
abstract: The present study was designed to investigate the antioxidant, anti-inflammatory and analgesic potential of Citrus decumana peel extract. Antioxidant activity of Citrus decumana peel extract in four solvent systems was evaluated by 1,1-diphenyl-2-picrylhydrazyl (DPPH(.)) and hydrogen peroxide (H(2)O(2)) radical scavenging methods. Ethyl acetate peel extract of Citrus decumana (EtCD) was studied for its anti-inflammatory and analgesic activities at a dose level of 100, 200 and 300 mg/kg. Anti-inflammatory activity was performed using carrageenan-induced paw edema in rats. Analgesic activity was evaluated for its central and peripheral pharmacological actions in mice. EtCD showed significant antioxidant activity in a dose-dependent manner when compared with ascorbic acid. EtCD at the dose of 300 mg/kg produced significant decrease in paw volume and pain when compared with reference drug diclofenac and morphine, respectively. The Citrus decumana peel extract may be useful as a natural antioxidant in the treatment of inflammation and pain.
authors.affiliation: Rayat Institute of Pharmacy, Nawanshahr District, Punjab, India. soodshalu@gmail.com
authors.forename: Shailja
authors.initials: S
authors.lastname: Sood
authors.forename: Bhawna
authors.initials: B
authors.lastname: Arora
authors.forename: Stuti
authors.initials: S
authors.lastname: Bansal
authors.forename: Arunachalam
authors.initials: A
authors.lastname: Muthuraman
authors.forename: Naresh Singh
authors.initials: NS
authors.lastname: Gill
authors.forename: Rashmi
authors.initials: R
authors.lastname: Arora
authors.forename: Manoj
authors.initials: M
authors.lastname: Bali
authors.forename: Pritam Dev
authors.initials: PD
authors.lastname: Sharma
mesh_terms: D000700:Analgesics / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology; D000975:Antioxidants / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology; D002957:Citrus / Q000737:chemistry*; D004008:Diclofenac / Q000494:pharmacology; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005260:Female; D007249:Inflammation / Q000188:drug therapy / Q000503:physiopathology; D008297:Male; D051379:Mice; D009020:Morphine / Q000494:pharmacology; D010146:Pain / Q000188:drug therapy / Q000503:physiopathology; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012997:Solvents / Q000737:chemistry
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D010936:Plant Extracts; D012997:Solvents; D004008:Diclofenac; D009020:Morphine; D001205:Ascorbic Acid