Nonclonal emergence of colistin-resistant Klebsiella pneumoniae isolates from blood samples in South Korea.
In vitro activities of colistin and other drugs were tested against 221 Klebsiella pneumoniae isolates that were collected between 2006 and 2007 in nine tertiary care South Korean hospitals from patients with bacteremia. The clonality of colistin-resistant K. pneumoniae (CRKP) isolates was assessed by multilocus sequence typing (MLST). We found that 15 isolates (6.8%) were resistant to colistin. MLST showed that CRKP isolates were nonclonal, with colistin resistance in K. pneumoniae occurring independently and not by clonal spreading.
Suh
Ji-Yoeun
JY
Asian-Pacific Research Foundation for Infectious Diseases (ARFID), Seoul, South Korea.
Son
Jun Seong
JS
Chung
Doo Ryeon
DR
Peck
Kyong Ran
KR
Ko
Kwan Soo
KS
Song
Jae-Hoon
JH
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D016470:Bacteremia / Q000382:microbiology; D003091:Colistin / Q000494:pharmacology*; D003428:Cross Infection / Q000382:microbiology; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D006801:Humans; D007710:Klebsiella Infections / Q000097:blood / Q000382:microbiology*; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000235:genetics*; D008826:Microbial Sensitivity Tests; D011159:Population Surveillance; D056910:Republic of Korea / Q000453:epidemiology
D000900:Anti-Bacterial Agents; D003091:Colistin