Synthesis of potent G-quadruplex binders of macrocyclic heptaoxazole and evaluation of their activities.
Guanine-rich DNA sequences form unique three-dimensional conformation known as G-quadruplexes (G-q). G-q structures have been found in telomere and in some oncogene promoter. Recently, it was suggested that G-q showed some biological activities including telomere shortening and transcriptional regulation. In this paper, we synthesized selective G-q binders and evaluated of their biological activities.
Tera
Masayuki
M
Department of Biotechnology and Life Science, Faculty of Technology, Tokyo University of Agriculture and Technology and Biological Information Research Center National Institute of Advanced Industrial Science and Techonology, Koganei, Tokyo 184-8588, Japan.
Iida
Keisuke
K
Shin-ya
Kazuo
K
Nagasawa
Kazuo
K
D004247:DNA / Q000737:chemistry; D054856:G-Quadruplexes; D010080:Oxazoles / Q000138:chemical synthesis / Q000737:chemistry*; D016615:Telomere / Q000737:chemistry*
C549549:L1H1-70TD compound; D010080:Oxazoles; D004247:DNA