title: Orbital infiltration as the first site of relapse of primary testicular T-cell lymphoma.
abstract: A 43-year-old male presented with a painless left testicular mass. The pathologic diagnosis of the radical orchiectomy specimen was peripheral T-cell lymphoma, unspecified (PTCL-u). According to the Ann Arbor staging system, his initial stage was III because of the right nasopharyngeal involvement. After first-line chemotherapy with four courses of the CHOP regimen and this was followed by involved-field radiotherapy, he achieved complete remission. Two months later, disease recurred to the left ciliary body of the left eye without evidence of involvement at other sites. Although the patient received intensive chemotherapy with autologous hematopoietic stem cell transplantation, he ultimately died of leptomeningeal seeding. Because both the central nervous system (CNS) and the orbit are sanctuary sites for chemotherapy, orbital infiltration of lymphoma should prompt physicians to evaluate involvement of the CNS and to consider performing prophylactic intrathecal chemotherapy as a treatment option.
authors.affiliation: Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Hyun Jung
authors.initials: HJ
authors.lastname: Jun
authors.forename: Won Seog
authors.initials: WS
authors.lastname: Kim
authors.forename: Ji Hyun
authors.initials: JH
authors.lastname: Yang
authors.forename: Seong Yoon
authors.initials: SY
authors.lastname: Yi
authors.forename: Young H
authors.initials: YH
authors.lastname: Ko
authors.forename: Jeeyun
authors.initials: J
authors.lastname: Lee
authors.forename: Chul Won
authors.initials: CW
authors.lastname: Jung
authors.forename: Se Woong
authors.initials: SW
authors.lastname: Kang
authors.forename: Keunchil
authors.initials: K
authors.lastname: Park