Role of Mangifera indica bark polyphenols on rat gastric mucosa against ethanol and cold-restraint stress.
This study was carried out in order to investigate the potential and antioxidant effects of polyphenols from Mangifera indica stem bark against gastric damage induced by ethanol and cold-restraint stress. The polyphenols possess good capacity for scavenging nitric oxide (NO) radical and ferric-reducing antioxidant power (FRAP) assay in vitro. Rats were sacrificed after the experiment, and their stomachs were removed for biochemical and histopathological analysis. The severity of lesions was found to markedly decrease by the administration of polyphenols in both models. The increased gastric nitrite level of ethanol administered rats were significantly (p < 0.001) reduced by polyphenol treatment. Administration of polyphenols reduced thiobarbituric acid reactive substance (TBARS) level and increased the GSH level significantly in a dose-dependent manner in both models. Our study revealed the ulcer-protective effects of the polyphenols and could possibly reside for the most part on its anti-radical effects.
Priya
T T
TT
Amala Cancer Research Centre, Thrissur, Kerala, India.
Sabu
M C
MC
Jolly
C I
CI
D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology; D003080:Cold Temperature; D000431:Ethanol / Q000633:toxicity; D005419:Flavonoids / Q000737:chemistry* / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D005978:Glutathione / Q000378:metabolism; D031022:Mangifera / Q000737:chemistry*; D010636:Phenols / Q000737:chemistry* / Q000494:pharmacology*; D024301:Plant Bark / Q000737:chemistry*; D059808:Polyphenols; D011899:Ranitidine / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012149:Restraint, Physical / Q000009:adverse effects*; D013272:Stomach Diseases / Q000139:chemically induced / Q000209:etiology / Q000517:prevention & control; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control; D013312:Stress, Physiological / Q000502:physiology*; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
D000897:Anti-Ulcer Agents; D005419:Flavonoids; D010636:Phenols; D059808:Polyphenols; D017392:Thiobarbituric Acid Reactive Substances; D000431:Ethanol; D011899:Ranitidine; D005978:Glutathione