[Antineutrophil cytoplasmic antibody associated vasculitis: an uncommon side effect of propylthiouracil].
BACKGROUND
Agranulocytosis or allergic skin reactions are common side effects of antithyroid drugs. Antineutrophil cytoplasmic antibody (ANCA) associated vasculitis is very uncommon.


METHODS
We report a 29-year-old woman treated with propylthiouracil for Graves' disease who developed a vasculitic skin involvement. ANCA with antimyeloperoxidase specificity were documented. Symptoms resolved after discontinuation of the drug.


CONCLUSIONS
ANCA associated vasculitis is an unusual complication of propylthiouracil. Prognosis is conditioned by renal and pulmonary involvement.
Pasquet
F
F
Service de médecine interne, endocrinologie, hôpital d'instruction des armées Desgenettes, Lyon, France. florianpasquet@wanadoo.fr
Pavic
M
M
Mounier
C
C
Karkowski
L
L
Colle
B
B
D000328:Adult; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000378:metabolism*; D013956:Antithyroid Agents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D011441:Propylthiouracil / Q000009:adverse effects*; D014657:Vasculitis / Q000139:chemically induced* / Q000276:immunology*
D019268:Antibodies, Antineutrophil Cytoplasmic; D013956:Antithyroid Agents; D011441:Propylthiouracil