Cytogenetic analysis of early nonviable pregnancies after assisted reproduction treatment.
In our series, a very high prevalence of chromosomal abnormalities was observed in spontaneous miscarriages, irrespective of how pregnancy was achieved, by assisted reproductive technology (ART) or natural conception. This high prevalence was equally represented in both groups, with no statistical difference in type of chromosomal abnormalities or in total frequency; however, the incidence of monosomy X is increased and the polyploidies are decreased in abortus after intracytoplasmic sperm injection (ICSI) when it is compared with miscarriages after spontaneous gestations.
Martínez
M Carmen
MC
Instituto Valenciano de Infertilidad in Murcia, Murcia, Spain. mcmartinez@ivi.es
Méndez
Carmen
C
Ferro
Jaime
J
Nicolás
Maria
M
Serra
Vicente
V
Landeras
Jose
J
D000022:Abortion, Spontaneous / Q000453:epidemiology / Q000235:genetics*; D000328:Adult; D016022:Case-Control Studies; D002869:Chromosome Aberrations; D041321:Chromosomes, Human, X; D041322:Chromosomes, Human, Y; D020732:Cytogenetic Analysis; D005260:Female; D005307:Fertilization in Vitro / Q000009:adverse effects; D005865:Gestational Age; D006801:Humans; D015994:Incidence; D007315:Insemination, Artificial / Q000009:adverse effects; D009006:Monosomy; D009030:Mosaicism; D011123:Polyploidy; D011247:Pregnancy; D015995:Prevalence; D027724:Reproductive Techniques, Assisted / Q000009:adverse effects*; D020554:Sperm Injections, Intracytoplasmic / Q000009:adverse effects; D017211:Treatment Failure; D014314:Trisomy