Reactive oxygen species scavenging activities and inhibition on DNA oxidative damage of dimeric compounds from the oxidation of (-)-epigallocatechin-3-O-gallate.
The dimeric catechins dehydrotheasinensin A (2) and theacitrin C (3) were prepared from the oxidation of (-)-epigallocatechin-3-O-gallate (EGCG, 1), and their antioxidant activity was investigated using a chemiluminescence (CL) method in vitro. Both compounds showed significant inhibitory effects on reactive oxygen species (O(2)(-), H(2)O(2) and *OH) and DNA oxidative damage, with 2 being more potent than 3 and EGCG itself.
Qi
Xiangyang
X
College of Biological Environmental Sciences, Zhejiang Wali College, Ningbo, China. qixiangyang85@sina.com
D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology*; D028241:Camellia sinensis / Q000737:chemistry*; D002392:Catechin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D004249:DNA Damage / Q000187:drug effects*; D019281:Dimerization; D010084:Oxidation-Reduction / Q000187:drug effects; D010936:Plant Extracts / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D018515:Plant Leaves; D017382:Reactive Oxygen Species / Q000378:metabolism
D000975:Antioxidants; D010936:Plant Extracts; D017382:Reactive Oxygen Species; C551166:dehydrotheasinensin A; C551167:theacitrin C; D002392:Catechin