title: Migration of limbal melanocytes onto the central cornea after ocular surface reconstruction: an in vivo confocal microscopic case report.
abstract: OBJECTIVE
  To report the in vivo confocal microscopic findings of migrated melanocytes onto the central cornea in a patient with Stevens-Johnson syndrome who received ocular surface reconstruction by amniotic membrane transplantation (AMT).
  
  
  METHODS
  Single interventional case report. A 37-year-old man presented with bilateral symblepharon because of Stevens-Johnson syndrome. Release of the bilateral symblepharon with AMT on the bare sclera was performed.
  
  
  RESULTS
  Three weeks after the surgery, slit-lamp biomicroscopy of the right eye revealed patchy brown pigmentation on the surface of the cornea and the amniotic membrane transplanted to the bare sclera. In vivo confocal microscopy of the affected cornea revealed abnormal basal epithelial cells with hyperreflective nuclei and loss of cellular borders. Multiple dendritiform cells, which appeared to be melanocytes, were distributed mainly on the corneal basal epithelial layer and superficial stroma. The number of the migrated melanocytes gradually decreased over 6 months of observation.
  
  
  CONCLUSIONS
  Melanocytes can migrate into the central cornea after reconstruction of the ocular surface with AMT. In vivo confocal microscopy can be a useful tool to observe these changes.
authors.affiliation: Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan.
authors.forename: Hsin-Wei
authors.initials: HW
authors.lastname: Huang
authors.forename: Fung-Rong
authors.initials: FR
authors.lastname: Hu
authors.forename: I-Jong
authors.initials: IJ
authors.lastname: Wang
authors.forename: Yu-Chih
authors.initials: YC
authors.lastname: Hou
authors.forename: Wei-Li
authors.initials: WL
authors.lastname: Chen
mesh_terms: D000328:Adult; D000650:Amnion / Q000637:transplantation; D002465:Cell Movement / Q000502:physiology*; D003315:Cornea / Q000473:pathology*; D006801:Humans; D016850:Limbus Corneae / Q000473:pathology; D008297:Male; D008544:Melanocytes / Q000473:pathology*; D018613:Microscopy, Confocal; D019651:Plastic Surgery Procedures; D013262:Stevens-Johnson Syndrome / Q000473:pathology* / Q000601:surgery