Synthesis and properties of a novel 2',4'-BNA bearing a urea bridged structure.
Three kinds of novel bridged nucleic acid (BNA) monomers bearing carbamate or urea bridged structures, were designed and synthesized. One of these monomers, a urea-type BNA monomer was successfully incorporated into oligodeoxynucleotides (ODNs), and properties of the ODNs were evaluated. The ODNs containing the urea-type BNA monomers showed RNA selective hybridizing profiles and significant enzymatic stability.
Yahara
Aiko
A
Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565-0871, Japan.
Nishida
Masaru
M
Baba
Takeshi
T
Kodama
Tetsuya
T
Imanishi
Takeshi
T
Obika
Satoshi
S
D001952:Bridged-Ring Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D002219:Carbamates / Q000737:chemistry; D004247:DNA / Q000737:chemistry; D009691:Nucleic Acid Denaturation; D009696:Nucleic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D009838:Oligodeoxyribonucleotides / Q000737:chemistry*; D012313:RNA / Q000737:chemistry; D014508:Urea / Q000737:chemistry*
D001952:Bridged-Ring Compounds; D002219:Carbamates; D009696:Nucleic Acids; D009838:Oligodeoxyribonucleotides; D012313:RNA; D014508:Urea; D004247:DNA