Specificities of atrial electrophysiology: Clues to a better understanding of cardiac function and the mechanisms of arrhythmias.
The electrical properties of the atria and ventricles differ in several aspects reflecting the distinct role of the atria in cardiac physiology. The study of atrial electrophysiology had greatly contributed to the understanding of the mechanisms of atrial fibrillation (AF). Only the atrial L-type calcium current is regulated by serotonine or, under basal condition, by phosphodiesterases. These distinct regulations can contribute to I(Ca) down-regulation observed during AF, which is an important determinant of action potential refractory period shortening. The voltage-gated potassium current, I(Kur), has a prominent role in the repolarization of the atrial but not ventricular AP. In many species, this current is based on the functional expression of K(V)1.5 channels, which might represent a specific therapeutic target for AF. Mechanisms regulating the trafficking of K(V)1.5 channels to the plasma membrane are being actively investigated. The resting potential of atrial myocytes is maintained by various inward rectifier currents which differ with ventricle currents by a reduced density of I(K1), the presence of a constitutively active I(KACh) and distinct regulation of I(KATP). Stretch-sensitive or mechanosensitive ion channels are particularly active in atrial myocytes and are involved in the secretion of the natriuretic peptide. Integration of knowledge on electrical properties of atrial myocytes in comprehensive schemas is now necessary for a better understanding of the physiology of atria and the mechanisms of AF.
Hatem
Stéphane N
SN
INSERM, UMRS-956, 75013 Paris, France. stephane.hatem@upmc.fr
Coulombe
Alain
A
Balse
Elise
E
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000378:metabolism* / Q000503:physiopathology; D001281:Atrial Fibrillation / Q000378:metabolism / Q000503:physiopathology; D002118:Calcium / Q000378:metabolism; D004594:Electrophysiology; D006325:Heart Atria / Q000378:metabolism*; D006801:Humans; D007473:Ion Channels / Q000378:metabolism / Q000502:physiology; D008954:Models, Biological; D032342:Muscle Cells / Q000378:metabolism / Q000502:physiology; D011188:Potassium / Q000378:metabolism
D007473:Ion Channels; D011188:Potassium; D002118:Calcium