title: Heritable factors play a major role in determining host responses to Wuchereria bancrofti infection in an isolated South Pacific island population.
abstract: BACKGROUND
  It is increasingly recognized that host genetic factors may play an important role in determining the outcome of filarial infections. To test this hypothesis in bancroftian lymphatic filariasis, pedigree data were collected twice during an 18-year period from an isolated Polynesian population living on a Pacific island where lymphatic filariasis is endemic.
  
  
  METHODS
  Using variance-component analysis, we examined the contribution of shared genetic and environmental effects on host clinical and immune responses to filarial infection, along with potential confounding determinants.
  
  
  RESULTS
  Sex was found to have a negligible influence on heritability estimates, but shared-household effects accounted for up to 32% of host variability. After accounting for these shared-household effects, heritability estimates suggested that levels of microfilariae and circulating adult worm antigen, as well as host eosinophil and immunoglobulin G antibody responses to larval and adult worm antigens, were highly heritable (range of heritability estimates, 0.15-0.84).
  
  
  CONCLUSIONS
  These data provide evidence of a key role for genetic factors in determining the host response to filarial infections in humans and emphasize the complexity of the relationships among the host, parasite, and environment.
authors.affiliation: Center for Craniofacial and Dental Genetics, Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pennsylvania, USA.
authors.forename: Karen T
authors.initials: KT
authors.lastname: Cuenco
authors.forename: Eric A
authors.initials: EA
authors.lastname: Ottesen
authors.forename: Steven A
authors.initials: SA
authors.lastname: Williams
authors.forename: Thomas B
authors.initials: TB
authors.lastname: Nutman
authors.forename: Cathy
authors.initials: C
authors.lastname: Steel
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000818:Animals; D002648:Child; D004605:Elephantiasis, Filarial / Q000235:genetics*; D019353:Endemic Diseases; D005260:Female; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006801:Humans; D008297:Male; D008875:Middle Aged; D011114:Polynesia / Q000453:epidemiology; D014958:Wuchereria bancrofti / Q000502:physiology*; D055815:Young Adult