title: Contact lens-related acanthamoeba keratitis.
abstract: Acanthamoeba keratitis is a rare but severe disease, with more than 95% of cases occurring in contact lens wearers. With a worldwide resurgence of contact lens-related disease, this report illustrates the clinical characteristics and treatment challenges representative of this disease. This report describes Acanthamoeba keratitis in a 47-year-old female using extended wear silicone hydrogel contact lenses, with a history of swimming in a home pool and failure to subsequently disinfect the contact lenses. The diagnosis was based on clinical signs, disease course, and confocal microscopy results despite a negative result for corneal smear and culture. The corneal signs included an epithelial defect, epithelial irregularities, anterior stromal infiltrates, perineural infiltrates, an anterior stromal ring infiltrate, and hypopyon. The case was diagnosed as an infective keratitis and treated promptly using intensive topical administration of fortified gentamicin and cephalothin. The high likelihood Acanthamoeba prompted immediate use of polyhexamethylbiguanide and chlorhexidine, with propamide and adjunct treatment using atropine and oral diclofenac. Steroids were added on day 3, and the frequency of administration of antibacterial treatment was gradually reduced and ceased by day 10. The analgesia was stopped at 3 months. The frequency of administration of antiamoeba therapy and steroid treatment was slowly reduced and all treatment was ceased after 18 months. Despite considerable morbidity in terms of the treatment duration, hospitalization, outpatient appointments, and associated disease costs, the final visual outcome (6/6) was excellent.
authors.affiliation: School of Optometry & Vision Science, University of New South Wales, Sydney, NSW 2052, Australia. F.Stapleton@unsw.edu.au
authors.forename: Fiona
authors.initials: F
authors.lastname: Stapleton
authors.forename: Jerome
authors.initials: J
authors.lastname: Ozkan
authors.forename: Isabelle
authors.initials: I
authors.lastname: Jalbert
authors.forename: Brien A
authors.initials: BA
authors.lastname: Holden
authors.forename: Con
authors.initials: C
authors.lastname: Petsoglou
authors.forename: Kathy
authors.initials: K
authors.lastname: McClellan
mesh_terms: D015823:Acanthamoeba Keratitis / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D000287:Administration, Topical; D000563:Amebicides / Q000008:administration & dosage; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage; D000981:Antiprotozoal Agents / Q000008:administration & dosage; D018639:Contact Lens Solutions; D003262:Contact Lenses, Extended-Wear / Q000009:adverse effects*; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D008875:Middle Aged; D012828:Silicones; D013256:Steroids / Q000008:administration & dosage; D013550:Swimming
chemical_list: D000563:Amebicides; D000891:Anti-Infective Agents, Local; D000981:Antiprotozoal Agents; D018639:Contact Lens Solutions; D012828:Silicones; D013256:Steroids; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate