Effect of alpha-tocopherol supplementation on renal oxidative stress and Na+/K+ -adenosine triphosphatase in ethanol treated Wistar rats.
Ethanol intoxication resulted in high extent of lipid peroxidation, and reduction in antioxidant defenses (decreased GSH, GSH/GSSG ratio, and catalase, SOD and GPx activities) and (Na+/K+)-ATPase activity in kidney. Alpha-tocopherol treatment effectively protected kidney from ethanol induced oxidative challenge and improved renal (Na+/K+)-ATPase activity. Ethanol induced oxidative stress in the kidney and decreased (Na+/K+)-ATPase activity could be reversed by treatment with ascorbic acid.
Mailankot
Maneesh
M
Melaka Manipal Medical College, Manipal 576 104, India. manu_only@hotmail.com
Jayalekshmi
H
H
Chakrabarti
Amit
A
Alang
Neha
N
Vasudevan
D M
DM
D000437:Alcoholism / Q000188:drug therapy / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage; D000431:Ethanol / Q000037:antagonists & inhibitors* / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D024502:alpha-Tocopherol / Q000008:administration & dosage*
D000975:Antioxidants; D000431:Ethanol; D000254:Sodium-Potassium-Exchanging ATPase; D024502:alpha-Tocopherol