title: A comparison of intravenous oxycodone and intravenous morphine in patient-controlled postoperative analgesia after laparoscopic hysterectomy.
abstract: BACKGROUND
  In this study, we investigated the dose requirements, pain relief, and side effects of oxycodone versus morphine after surgery with visceral pain.
  
  
  METHODS
  Ninety-one women received IV oxycodone or morphine before the end of laparoscopic hysterectomy and then continued with patient-controlled analgesia for 24 h postoperatively.
  
  
  RESULTS
  The accumulated oxycodone consumption was less (13.3 +/- 10.4 mg vs 22.0 +/- 13.1 mg, P = 0.001) than morphine. With oxycodone, the visual analog scale scores were significantly lower in the first hour postoperatively and sedation was less during the 24-h postoperative period, P = 0.006.
  
  
  CONCLUSIONS
  Oxycodone was more potent than morphine for visceral pain relief but not for sedation.
authors.affiliation: University of Oslo, Faculty Division Ullevaal University Hospital, Oslo, Norway. harald.lenz@medisin.uio.no
authors.forename: Harald
authors.initials: H
authors.lastname: Lenz
authors.forename: Leiv
authors.initials: L
authors.lastname: Sandvik
authors.forename: Erik
authors.initials: E
authors.lastname: Qvigstad
authors.forename: Carl Eivind
authors.initials: CE
authors.lastname: Bjerkelund
authors.forename: Johan
authors.initials: J
authors.lastname: Raeder
mesh_terms: D000328:Adult; D016058:Analgesia, Patient-Controlled; D000701:Analgesics, Opioid / Q000008:administration & dosage* / Q000009:adverse effects; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007044:Hysterectomy; D007275:Injections, Intravenous; D010535:Laparoscopy; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage* / Q000009:adverse effects; D010098:Oxycodone / Q000008:administration & dosage* / Q000009:adverse effects; D010147:Pain Measurement; D010149:Postoperative Pain / Q000517:prevention & control*; D012890:Sleep / Q000187:drug effects; D013997:Time Factors
chemical_list: D000701:Analgesics, Opioid; D009020:Morphine; D010098:Oxycodone