Cytokines and liver regeneration after partial portal vein ligation in porcine experimental model.
OBJECTIVE
The limits of liver surgery are restricted today by the functional reserves of remnant parenchyma. The aim of this article was to acquaint the general surgical and medical public with the results of experimental liver regeneration stimulated by cytokines and thus to enhance their effort to carry on with implementing the research results in clinical practice.


METHODS
Authors present their experimental model of liver regeneration after ligation of portal branches for caudate and right lateral, and right medial liver lobes. The regeneration was induced by application of TNF-alpha and IL-6 into the non-occluded portal branches, and compared with the results of other experimental teams.


CONCLUSIONS
The absolute volume of hypertrophic lobes increases after application of TNF-alpha more rapidly, whereas in the control group, practically no changes were recorded in hypertrophic liver lobes volumes in first three days. The achieved acceleration of growth of hypertrophic liver lobes after application of TNF-alpha and IL-6 confirmed the key role of studied pleiotropic cytokines in the priming of liver parenchyma regeneration after portal vein ligation (Fig. 3, Ref. 26).
Liska
V
V
Department of Surgery, Charles University, Medical School and Teaching Hospital Plzen, Czech Republic. Vena.Liska@seznam.cz
Treska
V
V
Skalicky
T
T
Mirka
H
H
Kobr
J
J
Sykora
R
R
Sutnar
A
A
Bruha
J
J
Fiala
O
O
Vycital
O
O
Chlumska
A
A
Holubec
L
L
Matejovic
M
M
D000818:Animals; D016207:Cytokines / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood / Q000494:pharmacology; D008026:Ligation; D008099:Liver / Q000098:blood supply; D008115:Liver Regeneration / Q000187:drug effects / Q000502:physiology*; D011169:Portal Vein / Q000601:surgery; D011994:Recombinant Proteins / Q000494:pharmacology; D013552:Swine; D014409:Tumor Necrosis Factor-alpha / Q000097:blood / Q000494:pharmacology
D016207:Cytokines; D015850:Interleukin-6; D011994:Recombinant Proteins; D014409:Tumor Necrosis Factor-alpha