[Association of oxidative stress and serum adiponectin in patients with metabolic syndrome].
OBJECTIVE
To analyze the correlation between oxidative stress and serum adiponectin in patients with metabolic syndrome (MS).


METHODS
A total of 126 patients with metabolic syndrome were recruited in the study, and 98 healthy physical examinees with normal serum glucose, lipids, liver function and kidney function were matched with the patients in age and sex and served as controls. The serum total adiponectin(Total-Ad), high molecular weight adiponectin (HMW-Ad) and indexes of oxidative stress [reduced glutathione (GSH), oxidized glutathione (GSSG) and malondialdehyde (MDA)] of the participants were determined. The correlations between adiponectin (Total-Ad and HMW-Ad) and the indexes of oxidative stress in the patients and the controls were determinaed by multiple linear regressions.


RESULTS
Compared with the controls, the patients had decreased Total-Ad [(3.51+/-0.83) microg/mL vs (4.34+/-0.98) microg/mL], HMW-Ad [(1.32+/-0.42) microg/mL vs (2.15+/-0.85) microg/mL] and GSH [(1.15+/-0.54) micromol/L vs (1.96+/-0.62) micromol/L], and increased GSSG [(1.20+/-0.47) micromol/L vs (0.90+/-0.23) micromol/L] and MDA [(6.92+/-1.50) nmol/L vs (4.05+/-0.65) nmol/L] (P<0.05). For the patients, total-Ad and HMW-Ad were positively correlated with GSH, with a partial correlation coefficient of 0.587 and 0.480 respectively (P<0.05), and negatively correlated with MDA, with a partial correlation coefficient of -0.222 and -0.389 respectively (P<0.05). For the controls, no correlations between adiponectin and oxidative stress indexes were found (P<0.05).


CONCLUSIONS
Oxidative stress accompanies MS patients. Adiponectin has a better correlation with GSH than the other indexes, which can serve as an index of oxidative stress. Hypoadiponectinemia correlates closely with oxidative stress in patients with MS.
He
Qiu-Rong
QR
Department of Clinical Chemistry Laboratory, West China Hospital, Sichuan University, Chengdu 610041, China.
Yu
Ting
T
Li
Ping
P
D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D005978:Glutathione / Q000097:blood*; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000378:metabolism; D008875:Middle Aged; D018384:Oxidative Stress
D052242:Adiponectin; D005978:Glutathione