title: Time trends in exposure of cattle to bovine spongiform encephalopathy and cohort effect in France and Italy: value of the classical Age-Period-Cohort approach.
abstract: BACKGROUND
  The Age-Period-Cohort (APC) analysis is routinely used for time trend analysis of cancer incidence or mortality rates, but in veterinary epidemiology, there are still only a few examples of this application. APC models were recently used to model the French epidemic assuming that the time trend for BSE was mainly due to a cohort effect in relation to the control measures that may have modified the BSE exposure of cohorts over time. We used a categorical APC analysis which did not require any functional form for the effect of the variables, and examined second differences to estimate the variation of the BSE trend. We also reanalysed the French epidemic and performed a simultaneous analysis of Italian data using more appropriate birth cohort categories for comparison.
  
  
  RESULTS
  We used data from the exhaustive surveillance carried out in France and Italy between 2001 and 2007, and comparatively described the trend of the epidemic in both countries. At the end, the shape and irregularities of the trends were discussed in light of the main control measures adopted to control the disease. In Italy a decrease in the epidemic became apparent from 1996, following the application of rendering standards for the processing of specific risk material (SRM). For the French epidemic, the pattern of second differences in the birth cohorts confirmed the beginning of the decrease from 1995, just after the implementation of the meat and bone meal (MBM) ban for all ruminants (1994).
  
  
  CONCLUSIONS
  The APC analysis proved to be highly suitable for the study of the trend in BSE epidemics and was helpful in understanding the effects of management and control of the disease. Additionally, such an approach may help in the implementation of changes in BSE regulations.
authors.affiliation: AFSSA-Lyon, 31 Avenue Tony Garnier, 69364 Lyon Cedex 7, France. c.sala@lyon.afssa.fr
authors.forename: Carole
authors.initials: C
authors.lastname: Sala
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Ru
mesh_terms: D000818:Animals; D002417:Cattle; D015331:Cohort Studies; D016643:Encephalopathy, Bovine Spongiform / Q000453:epidemiology*; D004812:Epidemiologic Methods / Q000662:veterinary*; D005602:France / Q000453:epidemiology; D007558:Italy / Q000453:epidemiology; D013997:Time Factors