Sex differences in a murine model of Sjögren's syndrome.
Sex differences in a NOD.H2(h4) murine model of Sjögren's syndrome were analyzed. Compared to males, female NOD.H2(h4) mice have increased severity of sialoadenitis and have a significantly increased percentage of CD4(+) T cells in salivary gland infiltrates. CD4(+) T cells in female infiltrates produce more Th2 and Th17 cytokines than in males, while males have greater Th1 responses. Females also have enhanced B cell responses, with higher levels of SSA and SSB serum antibodies, and B cell activation factor F (BAFF). Thus, sex has a strong impact on the severity of murine Sjögren's syndrome by affecting the immune mechanisms driving the autoimmune inflammation.
Ciháková
Daniela
D
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Talor
Monica V
MV
Barin
Jobert G
JG
Baldeviano
G Christian
GC
Fairweather
DeLisa
D
Rose
Noel R
NR
Burek
C Lynne
CL
D000818:Animals; D039481:CD11b Antigen / Q000378:metabolism; D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism / Q000473:pathology; D016207:Cytokines / Q000378:metabolism*; D004195:Disease Models, Animal; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D016753:Interleukin-10 / Q000378:metabolism; D020381:Interleukin-17 / Q000378:metabolism; D007376:Interleukin-2 / Q000378:metabolism; D015847:Interleukin-4 / Q000378:metabolism; D016906:Interleukin-9 / Q000378:metabolism; D017493:Leukocyte Common Antigens / Q000378:metabolism; D008264:Macrophages / Q000378:metabolism / Q000473:pathology; D008297:Male; D051379:Mice; D020297:Mice, Congenic; D016688:Mice, Inbred NOD; D012469:Salivary Glands / Q000378:metabolism / Q000473:pathology; D012737:Sex Factors; D012793:Sialadenitis / Q000378:metabolism / Q000473:pathology; D012859:Sjogren's Syndrome / Q000378:metabolism* / Q000473:pathology*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D039481:CD11b Antigen; D016207:Cytokines; D020381:Interleukin-17; D007376:Interleukin-2; D016906:Interleukin-9; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D015847:Interleukin-4; D017493:Leukocyte Common Antigens