Serotonin 1A receptor gene is associated with Japanese methamphetamine-induced psychosis patients.
BACKGROUND
Several investigations have reported associations the serotonin 1A (5-HT1A) receptor to schizophrenia and psychotic disorders, making 5-HT1A receptor gene (HTR1A) an adequate candidate gene for the pathophysiology of schizophrenia and methamphetamine (METH)-induced psychosis. Huang and colleagues reported that rs6295 in HTR1A was associated with schizophrenia. The symptoms of methamphetamine (METH)-induced psychosis are similar to those of paranoid type schizophrenia. It may indicate that METH-induced psychosis and schizophrenia have common susceptibility genes. In support of this hypothesis, we reported that the V-act murine thymoma viral oncogene homologue 1 (AKT1) gene was associated with METH-induced psychosis and schizophrenia in the Japanese population. Furthermore, we conducted an analysis of the association of HTR1A with METH-induced psychosis.


METHODS
Using one functional SNP (rs6295) and one tagging SNP (rs878567), we conducted a genetic association analysis of case-control samples (197 METH-induced psychosis patients and 337 controls) in the Japanese population. The age and sex of the control subjects did not differ from those of the methamphetamine dependence patients.


RESULTS
Rs878567 was associated with METH-induced psychosis patients in the allele/genotype-wise analysis. Moreover, this significance remained after Bonferroni correction. In addition, we detected an association between rs6295 and rs878567 in HTR1A and METH-induced psychosis patients in the haplotype-wise analysis. Although we detected an association between rs6295 and METH-induced psychosis patients, this significance disappeared after Bonferroni correction.


CONCLUSIONS
HTR1A may play an important role in the pathophysiology of METH-induced psychosis in the Japanese population. However, because we did not perform a mutation scan of HTR1A, a replication study using a larger sample may be required for conclusive results.
Kishi
Taro
T
Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi 470-1192, Japan. tarok@fujita-hu.ac.jp
Tsunoka
Tomoko
T
Ikeda
Masashi
M
Kitajima
Tsuyoshi
T
Kawashima
Kunihiro
K
Okochi
Tomo
T
Okumura
Takenori
T
Yamanouchi
Yoshio
Y
Kinoshita
Yoko
Y
Ujike
Hiroshi
H
Inada
Toshiya
T
Yamada
Mitsuhiko
M
Uchimura
Naohisa
N
Sora
Ichiro
I
Iyo
Masaomi
M
Ozaki
Norio
N
Iwata
Nakao
N
D000328:Adult; D019969:Amphetamine-Related Disorders / Q000235:genetics*; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D000697:Central Nervous System Stimulants / Q000633:toxicity*; D005260:Female; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D007564:Japan; D015810:Linkage Disequilibrium; D008297:Male; D008694:Methamphetamine / Q000633:toxicity*; D020641:Polymorphism, Single Nucleotide; D011605:Psychoses, Substance-Induced / Q000235:genetics*; D044282:Receptor, Serotonin, 5-HT1A / Q000235:genetics*; D017422:Sequence Analysis, DNA
D000697:Central Nervous System Stimulants; D044282:Receptor, Serotonin, 5-HT1A; D008694:Methamphetamine