Retrospective evaluation of CO(2) laser conization in pregnant women with carcinoma in situ or microinvasive carcinoma.
BACKGROUND
We evaluated the safety and efficacy of CO(2) laser conization in pregnant women with cervical intraepithelial neoplasia 3/carcinoma in situ (CIN3/CIS) or microinvasive carcinoma (MIC).


OBJECTIVE
A total of 49 pregnant women with biopsy-proven CIN3/CIS (30 patients) or MIC (19 patients) were studied.


METHODS
Retrospective analysis based on clinical records.


RESULTS
Median age and median week of gestation were 31 years (range: 22-39) and 17 weeks (range: 7-33), respectively. The median length of cervix resected by conization, median duration of surgery and median blood loss were 14 mm (range: 5-23), 20 min (range: 7-35) and 78 ml (range: 10-797), respectively. One biopsy-proven CIN3/CIS patient was diagnosed with Federation of Gynecology and Obstetrics (FIGO) Ia2 and 3 biopsy-proven MIC patients were diagnosed with FIGO Ib1 based on conization specimens. A total of 35 patients could be followed until delivery, of which 27 (77.1%) patients delivered transvaginally. Although 8 patients (22.9%) had a cesarean section and 6 patients (17.1%) delivered preterm, no conization-related obstetric complications were observed.


CONCLUSIONS
Since it results in few obstetric complications, CO(2) laser conization within 20 mm of length can be considered a safe procedure for pregnant women.
Tsuritani
Mitsuhiro
M
Department of Obstetrics and Gynecology, Kinki University School of Medicine, Osaka, Japan.
Watanabe
Yoh
Y
Kotani
Yasushi
Y
Kataoka
Taeko
T
Ueda
Haruhiko
H
Hoshiai
Hiroshi
H
D000328:Adult; D001706:Biopsy; D002585:Cesarean Section / Q000706:statistics & numerical data; D019092:Conization / Q000009:adverse effects / Q000379:methods*; D005260:Female; D006801:Humans; D054020:Lasers, Gas; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000601:surgery*; D011256:Pregnancy Outcome; D047928:Premature Birth / Q000453:epidemiology; D012189:Retrospective Studies; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000601:surgery*; D002578:Uterine Cervical Dysplasia / Q000473:pathology / Q000601:surgery*