title: [Effect of phospholipid composition on characteristics of liposomes containing zedoary turmeric oil].
abstract: OBJECTIVE
  To study the effect of phospholipids composition on pharmaceutical characteristics of liposomes containing zedoary turmeric oil (ZTO).
  
  
  METHODS
  The ZTO was extracted supersonically by solvent and then colored by sulfuric acid-vanillin reagent. The ZTO liposomes were prepared by ethanol injection method. To determine the entrapment efficiency of the ZTO liposomes, we passed the liposome suspension through a Sephadex G-50 column equilibrated with PBS. Pharmaceutical characteristics of different liposomes such as size, zata potential, entrapment efficiency, stablility were determined and compared.
  
  
  RESULTS
  The ZTO liposomes and free drug could be separated completely by the Sephadex G-50 chromatography, and the column recovery was (100.09+/-3.375)% (n=5). The ZTO liposomes composed of hydrogenated soybean phosphatidylcholine (HSPC) possessed the worst entrapment efficiency and sedimentation stability. The entrapment efficiency of the ZTO liposomes composed of soybean phosphatidylcholine (SPC) was equal to that of liposomes composed of both HSPC and SPC. However, The sedimentation and leakage stabilities of the latter were significantly higher than those of SPC liposomes.
  
  
  CONCLUSIONS
  As the carrier of the ZTO liposomes, the composition of both HSPC and SPC can improve its stability.
authors.affiliation: College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210046, China. chenjun75@163.com
authors.forename: Jun
authors.initials: J
authors.lastname: Chen
authors.forename: Kai
authors.initials: K
authors.lastname: Zhu
authors.forename: Na-Na
authors.initials: NN
authors.lastname: Cheng
authors.forename: Wei-Mei
authors.initials: WM
authors.lastname: Wang
authors.forename: Zheng
authors.initials: Z
authors.lastname: Bian
authors.forename: Tu-Lin
authors.initials: TL
authors.lastname: Lu
authors.forename: Chun-Qin
authors.initials: CQ
authors.lastname: Mao
authors.forename: Bao-Chang
authors.initials: BC
authors.lastname: Cai
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry*; D030024:Curcuma / Q000737:chemistry; D004337:Drug Carriers; D006865:Hydrogenation; D008081:Liposomes; D009822:Oils, Volatile / Q000008:administration & dosage / Q000737:chemistry* / Q000302:isolation & purification; D010316:Particle Size; D010713:Phosphatidylcholines / Q000737:chemistry* / Q000302:isolation & purification; D010743:Phospholipids / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry; D027343:Rhizome / Q000737:chemistry; D012995:Solubility; D013025:Glycine max / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D008081:Liposomes; D009822:Oils, Volatile; D010713:Phosphatidylcholines; D010743:Phospholipids