title: Fluorescent glycan derivatives: their use for natural glycan microarrays.
abstract: Glycan microarrays have become powerful tools in the investigation of biological systems because they enable fast, quantitative, and simultaneous analysis of glycan-protein interactions with small quantities of samples. One hurdle in the construction of glycan microarrays is to obtain a diverse set of glycans for immobilization on surfaces. An article in this issue of ACS Chemical Biology describes the microscale preparation of fluorescently labeled reactive glycans in a cyclic form of the reducing sugar, from natural sources, that can be utilized directly to create natural glycan microarrays for use in functional glycomics.
authors.affiliation: Department of Chemistry, Yonsei University, Seoul 120-749, Korea. injae@yonsei.ac.kr
authors.forename: Sungjin
authors.initials: S
authors.lastname: Park
authors.forename: Jung-Won
authors.initials: JW
authors.lastname: Sung
authors.forename: Injae
authors.initials: I
authors.lastname: Shin
mesh_terms: D005456:Fluorescent Dyes / Q000032:analysis*; D054794:Glycomics / Q000379:methods; D011134:Polysaccharides / Q000032:analysis* / Q000378:metabolism; D040081:Protein Array Analysis / Q000379:methods*; D011485:Protein Binding; D011506:Proteins / Q000032:analysis / Q000378:metabolism*
chemical_list: D005456:Fluorescent Dyes; D011134:Polysaccharides; D011506:Proteins