Structural interactomics: informatics approaches to aid the interpretation of genetic variation and the development of novel therapeutics.
Here we review the use of informatics in structural interactomics, with particular emphasis on understanding interfacial contacts in the development of novel therapeutics and the interpretation of genetic variation. We describe the availability and applicability of structural databases of protein interactions which facilitate this endeavour. We demonstrate the applicability of a structural interactomics approach to the study of the fibroblast growth factor (FGF)-stimulated mitogen-activated protein kinase (MAPK) pathway.
Lee
Semin
S
Department of Biochemistry, University of Cambridge, Old Addenbrookes site, 80 Tennis Court Road, Cambridge, UK.
Brown
Alan
A
Pitt
William Ross
WR
Higueruelo
Alicia Perez
AP
Gong
Sungsam
S
Bickerton
George Richard
GR
Schreyer
Adrian
A
Tanramluk
Duangrudee
D
Baylay
Alison
A
Blundell
Tom Leon
TL
D019295:Computational Biology; D030541:Databases, Genetic; D055808:Drug Discovery; D014644:Genetic Variation; D006801:Humans; D025941:Protein Interaction Mapping; D015398:Signal Transduction