Resolving the CSN and CAND1 paradoxes.
In this issue of Molecular Cell, Schmidt et al. (2009) untangle the interplay between the COP9 signalosome (CSN), cullin-associated and neddylation-dissociated 1 (CAND1) protein, and cullin-RING ubiquitin ligases (CRLs).
Dubiel
Wolfgang
W
Department of General, Visceral, Vascular and Thoracic Surgery, Charité - Universitätsmedizin Berlin, Germany. wolfgang.dubiel@charite.de
D016203:CDC2 Protein Kinase / Q000378:metabolism; D000075686:COP9 Signalosome Complex; D017124:Conserved Sequence; D044842:Cullin Proteins / Q000737:chemistry / Q000378:metabolism*; D010450:Endopeptidases / Q000378:metabolism; D044783:F-Box Proteins / Q000737:chemistry / Q000378:metabolism*; D045726:Metalloproteases / Q000378:metabolism; D008958:Models, Molecular; D046912:Multiprotein Complexes / Q000378:metabolism*; D010447:Peptide Hydrolases / Q000378:metabolism*; D011392:Proline; D011485:Protein Binding; D055550:Protein Stability; D044843:SKP Cullin F-Box Protein Ligases / Q000378:metabolism; D012568:Schizosaccharomyces / Q000201:enzymology*; D029702:Schizosaccharomyces pombe Proteins / Q000737:chemistry / Q000378:metabolism*; D014452:Ubiquitins / Q000378:metabolism
D044842:Cullin Proteins; D044783:F-Box Proteins; D046912:Multiprotein Complexes; C499610:Ned8 protein, S pombe; C449205:Pof10 protein, S pombe; C514993:Pof3 protein, S pombe; D029702:Schizosaccharomyces pombe Proteins; D014452:Ubiquitins; D011392:Proline; D044843:SKP Cullin F-Box Protein Ligases; C504781:SKP1 protein, S pombe; D016203:CDC2 Protein Kinase; C469447:cdc2 protein, S pombe; D010450:Endopeptidases; D045726:Metalloproteases; D010447:Peptide Hydrolases; D000075686:COP9 Signalosome Complex; C506284:Csn5 protein, S pombe; C474614:Ubp12 protein, S pombe