Dual infection with dengue virus 3 and human immunodeficiency virus 1 in Havana, Cuba.
Although dengue virus (DEN) endemic regions overlap with human immunodeficiency virus 1 (HIV) high incidence areas, little has been documented on HIV and DEN mixed infection. Here we report DEN/HIV concurrent infections recorded during the DEN-3 epidemic in 2001-2002 in Havana. Serologic-confirmed DEN is described in two HIV-infected subjects with dengue fever symptoms. Although patients had dengue disease, the CD4+ cells remained within normal levels and no accelerated progression of HIV disease was observed. To our knowledge, DEN cases caused by DEN-3 in HIV-infected individuals have not been reported previously. Further research is needed to diagnose this likely underreported mixed viral infection in DEN endemic areas.
Gonzalez
Daniel
D
Department of Medicine, Pedro Kouri Tropical Medicine Institute, Havana, Cuba.
Limonta
Daniel
D
Bandera
Juan Francisco
JF
Perez
Jorge
J
Kouri
Gustavo
G
Guzman
Maria G
MG
D000328:Adult; D018791:CD4 Lymphocyte Count; D003462:Cuba; D003715:Dengue / Q000150:complications* / Q000175:diagnosis* / Q000453:epidemiology; D003716:Dengue Virus / Q000302:isolation & purification; D015658:HIV Infections / Q000150:complications* / Q000175:diagnosis*; D015497:HIV-1 / Q000302:isolation & purification; D006801:Humans; D008297:Male; D055815:Young Adult