Chemokine receptor signaling and HIV infection.
The primary function of HIV-1 binding to its chemokine coreceptors is to mediate fusion and viral entry. However, it has been known that this interaction also triggers a variety of signaling cascades. It is likely that the virus-mediated signaling events may facilitate viral infection in various settings where the cellular conditions need to be primed. This has been exemplified recently in our findings that HIV-1 employs envelope-CXCR4 interaction to activate a cellular actin depolymerization factor, cofilin, to support viral latent infection of resting CD4 T cells. Activation of cofilin promotes the cortical actin dynamics that are critical for viral intracellular migration across the static cortical actin barrier in resting T cells.
Wu
Yuntao
Y
Department of Molecular and Microbiology, George Mason University, Manassas, VA, USA.
D000199:Actins / Q000378:metabolism; D000906:Antibodies / Q000276:immunology / Q000494:pharmacology; D015153:Blotting, Western; D015704:CD4 Antigens / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects / Q000378:metabolism* / Q000821:virology*; D002478:Cells, Cultured; D015699:HIV Envelope Protein gp120 / Q000494:pharmacology; D015658:HIV Infections / Q000503:physiopathology*; D006801:Humans; D019718:Receptors, CXCR4 / Q000276:immunology; D019707:Receptors, Chemokine / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects
D000199:Actins; D000906:Antibodies; D015704:CD4 Antigens; D015699:HIV Envelope Protein gp120; D019718:Receptors, CXCR4; D019707:Receptors, Chemokine