title: Chagas disease, adipose tissue and the metabolic syndrome.
abstract: Trypanosoma cruzi infection of the adipose tissue of mice triggers the local expression of inflammatory mediators and a reduction in the expression of the adipokine adiponectin. T. cruzi can be detected in adipose tissue by PCR 300 days post-infection. Infection of cultured adipocytes results in increased expression of cytokines and chemokines and a reduction in the expression of adiponectin and the peroxisome proliferator-activated receptor gamma, both of which are negative regulators of inflammation. Infection also results in the upregulation of cyclin D1, the Notch pathway, and extracellular signal-regulated kinase and a reduction in the expression of caveolin-1. Thus, T. cruzi infection of cultured adipocytes leads to an upregulation of the inflammatory process. Since adiponectin null mice have a cardiomyopathic phenotype, it is possible that the reduction in adiponectin contributes to the pathogenesis of chagasic cardiomyopathy. Adipose tissue may serve as a reservoir for T. cruzi from which parasites can become reactivated during periods of immunosuppression. T. cruzi infection of mice often results in hypoglycemia. In contrast, hyperglycemia as observed in diabetes results in increased parasitemia and mortality. Adipose tissue is an important target tissue of T. cruzi and the infection of this tissue is associated with a profound impact on systemic metabolism, increasing the risk of metabolic syndrome.
authors.affiliation: Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
authors.forename: Fnu
authors.initials: F
authors.lastname: Nagajyothi
authors.forename: Mahalia S
authors.initials: MS
authors.lastname: Desruisseaux
authors.forename: Louis M
authors.initials: LM
authors.lastname: Weiss
authors.forename: Streamson
authors.initials: S
authors.lastname: Chua
authors.forename: Chris
authors.initials: C
authors.lastname: Albanese
authors.forename: Fabiana S
authors.initials: FS
authors.lastname: Machado
authors.forename: Lisia
authors.initials: L
authors.lastname: Esper
authors.forename: Michael P
authors.initials: MP
authors.lastname: Lisanti
authors.forename: Mauro M
authors.initials: MM
authors.lastname: Teixeira
authors.forename: Philipp E
authors.initials: PE
authors.lastname: Scherer
authors.forename: Herbert B
authors.initials: HB
authors.lastname: Tanowitz
mesh_terms: D017667:Adipocytes / Q000469:parasitology*; D052242:Adiponectin / Q000378:metabolism; D000273:Adipose Tissue / Q000378:metabolism / Q000469:parasitology*; D000818:Animals; D014355:Chagas Disease / Q000378:metabolism*; D004195:Disease Models, Animal; D024821:Metabolic Syndrome / Q000378:metabolism / Q000469:parasitology*; D047495:PPAR gamma / Q000378:metabolism
chemical_list: D052242:Adiponectin; D047495:PPAR gamma