An efficient cascade synthesis of various 2H-1,4-benzoxazin-3-(4H)-ones from o-halophenols and 2-halo-amides catalyzed by CuI.
A novel and efficient one-pot cascade synthesis of 2H-1,4-benzoxazin-3-(4H)-ones has been developed through copper-catalyzed coupling of o-halophenols and 2-halo-amides. Various 2H-1,4-benzoxazin-3-(4H)-ones with diversity at three substituents on their scaffold have been synthesized conveniently in good to excellent yields.
Chen
Dingben
D
Department of Chemistry, Zhejiang University, Xi Xi Campus, Hangzhou, 310028, Zhejiang, PR China.
Shen
Guodong
G
Bao
Weiliang
W
D000577:Amides / Q000737:chemistry*; D048588:Benzoxazines / Q000138:chemical synthesis* / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006219:Halogens / Q000737:chemistry*; D007454:Iodides / Q000737:chemistry*; D010636:Phenols / Q000737:chemistry*
D000577:Amides; D048588:Benzoxazines; D006219:Halogens; D007454:Iodides; D010636:Phenols; D003300:Copper; C073870:cuprous iodide