title: Interleukin-10 responses to therapeutic vaccination during highly active antiretroviral therapy and after analytical therapy interruption.
abstract: We investigated whether therapeutic vaccination in highly active antiretroviral therapy (HAART)-treated patients with a modified vaccinia virus Ankara-vectored HIV-1 vaccine, with or without therapy interruption, induced the production of interleukin (IL)-10. Plasma IL-10 levels were not significantly increased postvaccination, but increased in parallel with viraemia in patients who interrupted therapy. Surprisingly, IL-10 blockade augmented HIV-specific T cell proliferative responses in HAART-suppressed patients but had no effect once virological control was lost. Modulation of IL-10 might enhance vaccine-induced immune responses.
authors.affiliation: MRC Human Immunology Unit and Oxford NIHR Biomedical Research Centre, Weatherall Institute of Molecular Medicine John Radcliffe Hospital, Oxford OX3 9DS, UK.
authors.forename: Hongbing
authors.initials: H
authors.lastname: Yang
authors.forename: Ana
authors.initials: A
authors.lastname: Guimarães-Walker
authors.forename: Stephen
authors.initials: S
authors.lastname: Hibbs
authors.forename: Tao
authors.initials: T
authors.lastname: Dong
authors.forename: Andrea
authors.initials: A
authors.lastname: Stacey
authors.forename: Persephone
authors.initials: P
authors.lastname: Borrow
authors.forename: Tomás
authors.initials: T
authors.lastname: Hanke
authors.forename: Miles P
authors.initials: MP
authors.lastname: Davenport
authors.forename: Andrew
authors.initials: A
authors.lastname: McMichael
authors.forename: Lucy
authors.initials: L
authors.lastname: Dorrell
mesh_terms: D016915:AIDS Vaccines / Q000276:immunology*; D019380:Anti-HIV Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology* / Q000517:prevention & control; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D016753:Interleukin-10 / Q000097:blood*; D012367:RNA, Viral; D019562:Viral Load
chemical_list: D016915:AIDS Vaccines; D019380:Anti-HIV Agents; D012367:RNA, Viral; D016753:Interleukin-10