title: [Giant condyloma of the penis with malignant transformation associated with lichen sclerosus et atrophicus].
abstract: A 72-year old patient presented with a 6 months history of a rapidly growing tumor of the glans and foreskin. He had a long history of phimosis with lichen sclerosus et atrophicus-like lesions on the foreskin which had not been treated. The rest of the personal, family and sexual history was unremarkable. Treatment consists of circumcision and tumor excision. Histopathology confirmed a squamous cell carcinoma within a giant condyloma with a concomitant lichen sclerosus et atrophicus. CT- and ultrasound scans showed no metastases. Giant condylomas are a rare sexually transmitted disease usually caused by human papilloma virus subtypes 6, 11, but also by 16 and 18 among others. They are expansive, cauliflower-like destructive lesions that most frequently affect the anogenital region. In about 30 percent a giant condyloma progresses into a squamous cell carcinoma. Therapy of choice is the histopathologically controlled excision. Recurrences are often seen, so the patients should be monitored frequently after therapy.
authors.affiliation: Hautklinik des Universitätsklinikums Düsseldorf.
authors.forename: U
authors.initials: U
authors.lastname: Wessendorf
authors.forename: D
authors.initials: D
authors.lastname: Bruch-Gerharz
authors.forename: S
authors.initials: S
authors.lastname: Braunstein
authors.forename: R
authors.initials: R
authors.lastname: Braunstein
authors.forename: K-W
authors.initials: KW
authors.lastname: Schulte
authors.forename: J
authors.initials: J
authors.lastname: Reifenberger
mesh_terms: D000368:Aged; D003218:Condylomata Acuminata / Q000150:complications* / Q000175:diagnosis*; D003937:Diagnosis, Differential; D006801:Humans; D018459:Lichen Sclerosus et Atrophicus / Q000150:complications* / Q000175:diagnosis*; D008297:Male; D010412:Penile Neoplasms / Q000150:complications* / Q000175:diagnosis*; D011230:Precancerous Conditions / Q000175:diagnosis*