Gene expression profiling in the aging ovary.
DNA microarray is an important discovery technology that allows the analysis of the expression of thousands of genes at a time. Data from DNA microarrays elucidate fundamental biological processes through discovery of differential expression of genes not previously known or predicted to be involved in a particular process. In the ovary and other hormone-responsive tissues, the technology can be used to examine the effects of gene mutations, pharmaceutical agents, disease, hormones, developmental changes, or changes in gene expression related to aging.
Eyster
Kathleen M
KM
Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD, USA.
Brannian
John D
JD
D000375:Aging / Q000235:genetics*; D000818:Animals; D005260:Female; D020869:Gene Expression Profiling; D051379:Mice; D008810:Mice, Inbred C57BL; D009693:Nucleic Acid Hybridization; D009765:Obesity / Q000235:genetics; D020411:Oligonucleotide Array Sequence Analysis; D010053:Ovary / Q000378:metabolism* / Q000502:physiology