title: Identifying left ventricular dysfunction in pulmonary hypertension.
abstract: The significance of left ventricular (LV) dysfunction in patients with pulmonary hypertension (PH) is unknown. Our purpose was to quantify LV function in PH patients by measuring LV myocardial performance index (MPI) and correlating it with invasively determined hemodynamic variables. The authors prospectively measured LV MPI via transthoracic echocardiography in 50 patients with PH (53+/-11 years; 35 women) who also underwent right heart catheterization within 1 day of echocardiography. For comparative purposes, LV MPI was also measured in 15 healthy volunteers who served as controls. LV MPI was significantly increased in the PH group compared with controls (0.62+/-0.27 vs 0.36+/-0.08; P<.001), indicating worse LV dysfunction despite that LV ejection fraction was not significantly different between the groups (58%+/-4% vs 60%+/-3%). LV MPI demonstrated significant correlations with invasively determined mean pulmonary artery pressure (r=.50; P<.001), pulmonary vascular resistance (r=.57; P<.001), and cardiac index (r=-.64; P<.001). By receiver operating characteristic analysis, LV MPI >0.75 predicted cardiac index <2 L/min/m(2) with 89% sensitivity and 78% specificity (area under the curve, 0.89). In a multivariate model, LV MPI was independently associated with cardiac index (P<.01). Patients with PH demonstrate abnormal LV function as quantified by elevated LV MPI, which correlates significantly with pulmonary vascular resistance and cardiac index.
authors.affiliation: Cardiovascular Institute, University of Pittsburgh Medical Center, PA 15213-2582, USA. rajagopalann@upmc.edu
authors.forename: Navin
authors.initials: N
authors.lastname: Rajagopalan
authors.forename: Marc A
authors.initials: MA
authors.lastname: Simon
authors.forename: Kathy
authors.initials: K
authors.lastname: Edelman
authors.forename: Michael A
authors.initials: MA
authors.lastname: Mathier
authors.forename: Angel
authors.initials: A
authors.lastname: López-Candales
mesh_terms: D016022:Case-Control Studies; D004452:Echocardiography; D005260:Female; D006305:Health Status Indicators; D006352:Heart Ventricles; D006801:Humans; D006976:Hypertension, Pulmonary / Q000175:diagnosis* / Q000000981:diagnostic imaging; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D012372:ROC Curve; D012307:Risk Factors; D012680:Sensitivity and Specificity; D013223:Statistics as Topic; D013318:Stroke Volume; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis* / Q000000981:diagnostic imaging; D016277:Ventricular Function, Left