title: Evaluation of the potential for interaction between a metaflumizone-amitraz combination and dexmedetomidine hydrochloride in dogs.
abstract: This study investigated the effects on cardiovascular parameters, if any, of a commercially available combination of metaflumizone and amitraz administered to healthy, telemetered beagles that were subsequently sedated with dexmedetomidine. Dogs were sedated first without any pretreatment and then after pretreatment with metaflumizone and amitraz. Baseline values of all parameters were within normal limits for all dogs before the first anesthetic event. At 10 and 20 minutes after onset of sedation, oxygen saturation as measured by pulse oximetry was significantly higher for dogs that were pretreated with metaflumizone and amitraz. At all times after induction of sedation, blood pressure, heart rate, and baseline body temperature for dogs pretreated with metaflumizone and amitraz were not statistically different from when they were not pretreated. In conclusion, prior treatment with metaflumizone and amitraz did not influence the hemodynamic response to dexmedetomidine in telemetered dogs.
authors.affiliation: Fort Dodge Animal Health, Princeton, NJ 08543, USA.
authors.forename: Raphael
authors.initials: R
authors.lastname: Zwijnenberg
authors.forename: William
authors.initials: W
authors.lastname: Muir
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D020927:Dexmedetomidine / Q000008:administration & dosage / Q000009:adverse effects*; D004283:Dog Diseases / Q000139:chemically induced*; D004285:Dogs; D004347:Drug Interactions; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006993:Hypnotics and Sedatives / Q000009:adverse effects; D007306:Insecticides / Q000009:adverse effects; D008297:Male; D012664:Semicarbazones / Q000008:administration & dosage / Q000009:adverse effects*; D014052:Toluidines / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D006993:Hypnotics and Sedatives; D007306:Insecticides; D012664:Semicarbazones; D014052:Toluidines; C014983:amitraz; D020927:Dexmedetomidine; C528570:metaflumizone