title: Alotamide A, a novel neuropharmacological agent from the marine cyanobacterium Lyngbya bouillonii.
abstract: Alotamide A (1), a structurally intriguing cyclic depsipeptide, was isolated from the marine mat-forming cyanobacterium Lyngbya bouillonii collected in Papua New Guinea. It features three contiguous peptidic residues and an unsaturated heptaketide with oxidations and methylations unlike those found in any other marine cyanobacterial metabolite. Pure alotamide A (1) displays an unusual calcium influx activation profile in murine cerebrocortical neurons with an EC50 of 4.18 microM.
authors.affiliation: Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92037, USA.
authors.forename: Irma E
authors.initials: IE
authors.lastname: Soria-Mercado
authors.forename: Alban
authors.initials: A
authors.lastname: Pereira
authors.forename: Zhengyu
authors.initials: Z
authors.lastname: Cao
authors.forename: Thomas F
authors.initials: TF
authors.lastname: Murray
authors.forename: William H
authors.initials: WH
authors.lastname: Gerwick
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D000458:Cyanobacteria / Q000737:chemistry*; D047630:Depsipeptides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D051379:Mice; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D009480:Neuropharmacology; D009792:Oceans and Seas
chemical_list: D047630:Depsipeptides; C545743:alotamide A; D002118:Calcium