Kidney transplantation during autoimmune diseases.
Herein, we report the results of kidney transplantation in 9 of 376 patients who underwent kidney transplantation at our center between 1986 and 2007 because of chronic renal failure associated with autoimmune disease. Four of the 9 patients had systemic lupus erythematosus, 3 had Wegener granulomatosis, and 2 had Goodpasture syndrome. Six patients received organs from living donors, and 3 received cadaver organs. Infections were frequent and included cytomegalovirus and urinary tract infection in most cases. There was no difference in occurrence of metabolic and cardiovascular complications in our study patients compared with other transplant recipients. Incidence of allograft loss (n = 1) was similar to that in our entire transplantation population, with an overall rate of 2.9%. We conclude that kidney transplantation is a reasonable therapeutic option in patients with autoimmune disease with end-stage renal disease because of good graft and patient survival compared with kidney recipients without autoimmune diseases.
Ounissi
M
M
Department of Internal Medicine A and Laboratory of Kidney Diseases, Charles Nicolle Hospital, Tunis, Tunisia. mejid66@yahoo.fr
Abderrahim
E
E
Hedri
H
H
Sfaxi
M
M
Fayala
H
H
Turki
S
S
Ben Maïz
H
H
Ben Abdallah
T
T
Chebil
M
M
Kheder
A
A
D000293:Adolescent; D019867:Anti-Glomerular Basement Membrane Disease / Q000150:complications; D001327:Autoimmune Diseases / Q000150:complications*; D002102:Cadaver; D002648:Child; D005260:Female; D006085:Graft Survival / Q000502:physiology; D014890:Granulomatosis with Polyangiitis / Q000150:complications; D006801:Humans; D007676:Kidney Failure, Chronic / Q000209:etiology* / Q000276:immunology / Q000601:surgery; D016030:Kidney Transplantation / Q000502:physiology*; D019520:Living Donors; D008297:Male; D017582:Renal Replacement Therapy; D015996:Survival Rate; D014019:Tissue Donors; D017211:Treatment Failure; D055815:Young Adult