The effect of low-level laser therapy on healing of skin incisions made using a diode laser in diabetic rats.
OBJECTIVE
To investigate the effect of low-level laser therapy (LLLT) on healing of skin incisions made using a diode laser in diabetic rats.


METHODS
Eighteen diabetic Wistar rats were used for this study. One incision was performed on the left side of the dorsum using a diode laser, and the other two incisions were made with a scalpel and diode laser on the right side of each rat. The wound on the left side of each rat received laser stimulation (10 J/cm(2)). The rats were assigned to three experimental groups. Group 1, scalpel (n = 18); Group 2, diode (n = 18); Group 3, diode + biostimulation (n = 18).


RESULTS
Reepithelialization was fastest in Group 2 than Group 1 at day 10. The difference between Groups 1 and 3 was also statistically significant in reepithelialization at day 10. There was a significant difference between Groups 1 and 2 and between Groups 2 and 3 in inflammation at day 10. There was no difference between any of the groups in inflammation and reepithelialization at day 20.


CONCLUSIONS
Scalpel incisions heal more slowly than diode and diode + biostimulation incisions in diabetic rats. We can suggest that diode + biostimulation may produce the least amount of tissue injury, with the fastest resolution of inflammatory response in diabetic rats. Diode laser incision (4 W) with 10-J/cm(2) LLLT seems to have a beneficial effect on skin incisions in diabetic rats.
Akyol
Utkan
U
Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Ataturk University, Erzurum, Turkey.
Güngörmüş
Metin
M
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000150:complications*; D004195:Disease Models, Animal; D054023:Lasers, Semiconductor; D028022:Low-Level Light Therapy / Q000295:instrumentation / Q000379:methods*; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000293:injuries* / Q000528:radiation effects*; D018709:Statistics, Nonparametric; D014945:Wound Healing / Q000528:radiation effects*