[Preparation and isolation on the rare ginsenoside derivatives with anti-cancer activity].
OBJECTIVE
To prepare and isolate the rare ginsenoside derivatives of anti-cancer activity.


METHODS
Acid-degradation products of ginsenosides were isolated and purified by various chromatographic techniques such as silica gel and so on; compounds were identified and elucidated by spectral and chemical methods.


RESULTS
Eleven compounds were obtained from the products of Acid-degradation.


CONCLUSIONS
Compound I, II are discoverd from the roots, stems, leaves, fruits and alabastrums of Panax quinquefolium L. for the first time. Compound IX of derivate of the aglycone of protopanoxadiol ginsenoside was discovered and reported, having the conspicuous anti-cancer activity for the first time from the fruits of Panax ginseng.
Liu
Na
N
Yanbian University, Yanji 133000, China.
Piao
Hu-Ri
HR
Zhao
Yu-Qing
YQ
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification*; D036145:Ginsenosides / Q000737:chemistry* / Q000302:isolation & purification*; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D005894:Panax / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D012502:Sapogenins / Q000737:chemistry / Q000302:isolation & purification*
D000972:Antineoplastic Agents, Phytogenic; D036145:Ginsenosides; D012502:Sapogenins; C062916:protopanaxadiol