title: Critical illness polyneuropathy: a rare but serious adverse event in pediatric oncology.
abstract: Critical illness polyneuropathy (CIP) may aggravate sepsis and multiorgan dysfunction in pediatric oncology patients characterized by quadriparesis and difficult weaning from mechanical ventilation. Here, we report on an adolescent patient with acute lymphoblastic T-cell leukemia who developed critical illness neuropathy after an episode of sepsis with need for mechanical ventilation and intravenous catecholamines. Differential diagnoses like vincristine-induced polyneuropathy, anterior lumbosacral radiculopathy (ALR), Guillain-Barré syndrome, and chronic inflammatory demyelinating polyneuropathy - all occurring in pediatric patients with acute leukemia - are discussed.
authors.affiliation: University Children's Hospital, University Medical Center, Martin-Luther University Halle-Wittenberg, Halle, Germany.
authors.forename: Jorma
authors.initials: J
authors.lastname: Charisius
authors.forename: Martina
authors.initials: M
authors.lastname: Stiefel
authors.forename: Nick
authors.initials: N
authors.lastname: Merkel
authors.forename: Malte
authors.initials: M
authors.lastname: Kornhuber
authors.forename: Roland
authors.initials: R
authors.lastname: Haase
authors.forename: Christof Maria
authors.initials: CM
authors.lastname: Kramm
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D002395:Catecholamines / Q000378:metabolism*; D003937:Diagnosis, Differential; D006801:Humans; D015458:Leukemia, T-Cell / Q000150:complications* / Q000188:drug therapy; D008297:Male; D011115:Polyneuropathies / Q000139:chemically induced / Q000150:complications* / Q000175:diagnosis; D012121:Respiration, Artificial; D018805:Sepsis / Q000139:chemically induced / Q000150:complications* / Q000175:diagnosis; D014750:Vincristine / Q000009:adverse effects*
chemical_list: D002395:Catecholamines; D014750:Vincristine