The growth hormone receptor gene-disrupted mouse fails to respond to an intermittent fasting diet.
The interaction of longevity-conferring genes with longevity-conferring diets is poorly understood. The growth hormone receptor gene-disrupted (GHR-KO) mouse is long lived; and this longevity is not responsive to 30% caloric restriction, in contrast to wild-type animals from the same strain. To determine whether this may have been limited to a particular level of dietary restriction, we subjected GHR-KO mice to a different dietary restriction regimen, an intermittent fasting diet. The intermittent fasting diet increased the survivorship and improved insulin sensitivity of normal males, but failed to affect either parameter in GHR-KO mice. From the results of two paradigms of dietary restriction, we postulate that GHR-KO mice would be resistant to any manner of dietary restriction; potentially due to their inability to further enhance insulin sensitivity. Insulin sensitivity may be a mechanism and/or a marker of the lifespan extending potential of an intervention.
Arum
Oge
O
Department of Internal Medicine, Southern Illinois University-School of Medicine, 801 N. Rutledge St., Springfield, IL 62794, USA. oarum@siumed.edu
Bonkowski
Michael S
MS
Rocha
Juliana S
JS
Bartke
Andrzej
A
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight; D005215:Fasting; D005260:Female; D005786:Gene Expression Regulation; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D011986:Receptors, Somatotropin / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D012727:Sex Characteristics
D001786:Blood Glucose; D011986:Receptors, Somatotropin