title: [Severe overdose in vitamin K antagonist secondary to grapefruit juice absorption].
abstract: Vitamin K antagonists (VKA) are very currently used. Nevertheless, they are known to interact with numerous drugs and foods. Grapefruit juice is known to interact with some drugs metabolized by the enterocytary cytochrome P450 3A4 but its interaction with drugs as VKA that have a good biodisponibility is not clearly demonstrated. We report here the case of a woman treated with VKA in whom massive absorption of grapefruit juice entailed an excessive VKA dosage and a severe haemorrhage.
authors.affiliation: Département d'anesthésie-réanimation chirurgicale, hôpital Bichat-Claude-Bernard, AP-HP de Paris, Paris, France. desmardmathieu@yahoo.fr
authors.forename: M
authors.initials: M
authors.lastname: Desmard
authors.forename: R
authors.initials: R
authors.lastname: Hellmann
authors.forename: G
authors.initials: G
authors.lastname: Plantefève
authors.forename: H
authors.initials: H
authors.lastname: Mentec
mesh_terms: D000042:Absorption; D000925:Anticoagulants / Q000009:adverse effects* / Q000378:metabolism*; D001628:Beverages / Q000009:adverse effects*; D032083:Citrus paradisi / Q000009:adverse effects* / Q000378:metabolism*; D062787:Drug Overdose; D005260:Female; D018565:Food-Drug Interactions; D006801:Humans; D008875:Middle Aged; D010630:Phenindione / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000378:metabolism; D012720:Severity of Illness Index; D014812:Vitamin K / Q000037:antagonists & inhibitors*
chemical_list: D000925:Anticoagulants; D014812:Vitamin K; D010630:Phenindione; C017673:fluindione