title: Commentary on "Alzheimer's Disease Drug Development and the Problem of the Blood-Brain Barrier".
abstract: The perspective by Dr. William Pardridge entitled "Alzheimer's Disease Drug Discovery and the Problem of the Blood-Brain Barrier" makes a strong case for the imbalance in resource distribution to the drug-discovery and brain drug delivery processes, where the latter received less than 1% of the investment of the former. My own calculations are consistent with this striking imbalance. Dr. Pardridge predicts that current trials of passive immunity against beta-amyloid peptide will likely fail, whereas past trials of active immunization exhibited trial-ending side effects, in part because of disruption of the integrity of the blood-brain barrier. To bring an assessment of the physiology of the blood-brain barrier and the brain delivery of drugs to the fore, several changes are needed in the way we perceive the problem, train our young scientists, organize research efforts, and incentivize reaching our common goals of effective drug therapy for Alzheimer's disease.
authors.affiliation: Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer's Disease Research, University of North Texas Health Science Center, Fort Worth, TX, USA. jsimpkin@hsc.unt.edu
authors.forename: James W
authors.initials: JW
authors.lastname: Simpkins
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy*; D001692:Biological Transport / Q000502:physiology; D001812:Blood-Brain Barrier / Q000502:physiology*; D002491:Central Nervous System Agents / Q000493:pharmacokinetics*; D016503:Drug Delivery Systems / Q000379:methods; D015195:Drug Design; D006801:Humans
chemical_list: D002491:Central Nervous System Agents