Design, synthesis and biological activities of new strobilurin derivatives containing substituted pyrazoles.
BACKGROUND
Strobilurins are one of the most important classes of agricultural fungicides. To discover new strobilurin analogues with high activity, a series of new strobilurin derivatives containing substituted pyrazoles in the side chain were synthesised and bioassayed.


RESULTS
The compounds were identified by (1)H NMR, IR, MS and elemental analysis. Preliminary bioassays indicated that some title compounds exhibited excellent fungicidal activities against Pseudoperonospora cubensis (Burk. & Curt.) Rostovsev and Erysiphe graminis DC f. sp. tritici Marchal, protecting cucumber and wheat at 6.25 and 1.56 mg L(-1) respectively, and showed a moderately high acaricidal activity against Tetranychus cinnabarinus (Boisd.) at 20 mg L(-1). The relationship between structure and biological activity is discussed in terms of effects of the substituent of the pyrazole ring.


CONCLUSIONS
The present work demonstrates that strobilurin analogues with substituted phenylpyrazolylmethoxymethyl side chains can be used as possible lead compounds for further developing novel fungicides and acaricides.
Li
Miao
M
Shenyang Research Institute of Chemical Industry, Shenyang, China.
Liu
Chang-Ling
CL
Li
Lin
L
Yang
Hao
H
Li
Zhi-Nian
ZN
Zhang
Hong
H
Li
Zheng-Ming
ZM
D056810:Acaricides / Q000138:chemical synthesis*; D000818:Animals; D005659:Fungicides, Industrial / Q000138:chemical synthesis*; D009868:Oomycetes; D010935:Plant Diseases; D011720:Pyrazoles / Q000737:chemistry*; D040102:Tetranychidae
D056810:Acaricides; D005659:Fungicides, Industrial; D011720:Pyrazoles