Restorative therapy in stroke using stem cells.
The nonregenerative capability of the injured adult brain has been challenged in recent years and neural plasticity has been observed experimentally in both global and focal brain ischemia in animal models. Whether neuro-genesis increases in response to brain lesions or stem cells can be used for transplantation are the potential questions to be answered. Functional recovery may occur in a small or a localized brain injury using rehabilitation measures, but for large ischemic strokes, the restoration may require new synaptic connections within and away from the damaged tissue. In an infarcted area, the ischemic core may not respond to any pharmacological or rehabilitative intervention. For these reasons, the prospects of repairing the neuron system, using cell transplantation seems promising and may offer a unique approach for brain repair and restoration of function. On going animal and human trials have greatly helped us to burgeon our hopes on this method of restorative therapy after stroke. The ultimate aim of any therapeutic strategy is the maximum restoration possible and eventual complete normalcy of function.
Padma Srivastava
M V
MV
Department of Neurology, All India Institute of Medical Sciences, New Delhi-110 029, India. vasanthapadma123@rediffmail.com
D000818:Animals; D002986:Clinical Trials as Topic; D006801:Humans; D007194:India; D009416:Nerve Regeneration / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology; D020127:Recovery of Function / Q000502:physiology*; D033581:Stem Cell Transplantation; D020521:Stroke / Q000601:surgery / Q000628:therapy*