[Potential therapeutic targets for diabetic nephropathy].
Diabetic nephropathy has emerged as the leading cause of end-stage renal disease. Intensive control of blood glucose and pressure has been the mainstay for the treatment of diabetic nephropathy and provided favorable evidence in slowing disease progression. However, current therapeutic regimens have not demonstrated satisfactory prevention of the nephropathy thus novel therapeutic agents are urgently needed. In diabetic conditions, multiple mechanisms have been implicated in glucose-mediated microvascular damage leading to nephropathy; activation of protein kinase C, accumulation of inflammatory mediators and advanced glycation end products, generation of reactive oxygen species, and other biochemical abnormalities. In turn, inhibiting these pathological mechanisms may represent a potential therapy for diabetic nephropathy. This review discusses current concepts innovel targeted therapy for diabetic kidney complications.
Makino
Yuichi
Y
Division of Metabolism and Biosystemic Science, Department of Medicine, Asahikawa Medical College.
Haneda
Masakazu
M
D003928:Diabetic Nephropathies / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans