Amino acid signaling to TOR activation: Vam6 functioning as a Gtr1 GEF.
In this issue of Molecular Cell, Binda et al. identify Vam6/Vps39 as a guanine nucleotide exchange factor for Gtr1, a Rag family GTPase, to promote TORC1 activation in response to amino acids.
Li
Li
L
Department of Pharmacology, Moores Cancer Center, University of California, San Diego, La Jolla, 92093, USA.
Guan
Kun-Liang
KL
D033942:Adaptor Proteins, Vesicular Transport / Q000235:genetics / Q000378:metabolism*; D000596:Amino Acids / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000378:metabolism; D011992:Endosomes / Q000201:enzymology; D020662:Guanine Nucleotide Exchange Factors / Q000235:genetics / Q000378:metabolism*; D006153:Guanosine Diphosphate / Q000378:metabolism; D006160:Guanosine Triphosphate / Q000378:metabolism; D006801:Humans; D007425:Intracellular Membranes / Q000201:enzymology; D020559:Monomeric GTP-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D046912:Multiprotein Complexes; D011494:Protein Kinases / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000201:enzymology* / Q000235:genetics / Q000254:growth & development; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D058570:TOR Serine-Threonine Kinases; D014157:Transcription Factors / Q000378:metabolism; D014617:Vacuoles / Q000201:enzymology
D033942:Adaptor Proteins, Vesicular Transport; D000596:Amino Acids; C500984:CRTC1 protein, human; D004268:DNA-Binding Proteins; C121263:GTR2 protein, S cerevisiae; C121262:Gtr1 protein, S cerevisiae; D020662:Guanine Nucleotide Exchange Factors; C501979:MEH1 protein, S cerevisiae; D046912:Multiprotein Complexes; C062214:SWI4 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; C485218:Tco89 protein, S cerevisiae; D014157:Transcription Factors; C406817:VAM6 protein, S cerevisiae; D006153:Guanosine Diphosphate; D006160:Guanosine Triphosphate; D011494:Protein Kinases; C546842:MTOR protein, human; D017346:Protein Serine-Threonine Kinases; D058570:TOR Serine-Threonine Kinases; C500749:target of rapamycin protein, S cerevisiae; D020559:Monomeric GTP-Binding Proteins