Docking simulation of polyamines on a kissing-loop RNA dimer.
Polyamines, especially branched polyamines such as tetrakis(3-aminopropyl)ammonium (Taa), stabilize the tertiary structure of RNA molecules. In this study, we examined the polyamine binding site of the HIV-1 dimerization initiation site (DIS) in the kissing-loop dimer by the docking simulation. It was found that Taa binds predominantly to the kissing loop interaction site of DIS.
Imai
Misaki
M
Department of Life and Environmental Sciences, Chiba Institute of Technology, Narashino-shi, Chiba 275-0016, Japan.
Chikatsu
Daisuke
D
Inomata
Emire
E
Oshima
Tairo
T
Kawai
Gota
G
D001665:Binding Sites; D003198:Computer Simulation; D019281:Dimerization; D015497:HIV-1 / Q000235:genetics*; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D011073:Polyamines / Q000737:chemistry*; D000644:Quaternary Ammonium Compounds / Q000737:chemistry*; D012367:RNA, Viral / Q000737:chemistry*
D011073:Polyamines; D000644:Quaternary Ammonium Compounds; D012367:RNA, Viral; C053493:tetrakis(3-aminopropyl)ammonium; C035585:caldopentamine