Effect of EP4 agonist (ONO-4819CD) for patients with mild to moderate ulcerative colitis refractory to 5-aminosalicylates: a randomized phase II, placebo-controlled trial.
Nakase
Hiroshi
H
Fujiyama
Yoshihide
Y
Oshitani
Nobuhide
N
Oga
Toru
T
Nonomura
Kimiko
K
Matsuoka
Toshiyuki
T
Esaki
Yoshiyasu
Y
Murayama
Toshinori
T
Teramukai
Satoshi
S
Chiba
Tsutomu
T
Narumiya
Shuh
S
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D003093:Colitis, Ulcerative / Q000188:drug therapy*; D004311:Double-Blind Method; D004351:Drug Resistance; D005260:Female; D006537:Heptanoates / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D019804:Mesalamine / Q000627:therapeutic use*; D008875:Middle Aged; D010919:Placebos; D018078:Receptors, Prostaglandin E / Q000819:agonists*; D058309:Receptors, Prostaglandin E, EP4 Subtype; D016896:Treatment Outcome
D000894:Anti-Inflammatory Agents, Non-Steroidal; D006537:Heptanoates; C487764:ONO4819; C545650:PTGER4 protein, human; D010919:Placebos; D018078:Receptors, Prostaglandin E; D058309:Receptors, Prostaglandin E, EP4 Subtype; D019804:Mesalamine