Estrogen receptor alpha (ER-alpha) gene polymorphism in patients from the Lodz region of Poland with sporadic endometrial cancer.
OBJECTIVE
Estrogens play a crucial role in the pathogenesis and progression of endometrial cancer. The gene ER-alpha is polymorphic and gene variability could contribute to the level of protein biosynthesis.


METHODS
The aim of this study was to evaluate PvuII and XbaI polymorphism of the ER-alpha gene in 120 postmenopausal women with endometrial cancer in DNA samples obtained from cancer tissue. The polymorphisms were determined by PCR-RFLP methods.


RESULTS
The distribution of the genotypes of PvuII and XbaI polymorphism of ER-alpha in both controls and patients did not differ significantly from those predicted by the Hardy-Weinberg distribution. There were no significant differences in genotype distributions and allele frequencies between subgroups assigned to histological stage.


CONCLUSIONS
The results suggest that the PvuII polymorphism of ER-alpha gene as well as XbaI polymorphism may not be linked with appearance and development of endometrial cancer.
Sobczuk
A
A
Department of Menopausal Disease, Institute of Polish Mother's Memorial Hospital Lodz, Poland. smolbea@wp.pl
Smolarz
B
B
Romanowicz-Makowska
H
H
Pertyński
T
T
D016889:Endometrial Neoplasms / Q000235:genetics*; D047628:Estrogen Receptor alpha / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length
D047628:Estrogen Receptor alpha