title: Metabolic syndrome and cancer-related mortality among Korean men and women.
abstract: BACKGROUND
  We examined the association between the metabolic syndrome and cancer mortality in Koreans.
  
  
  METHODS
  This study included 42 336 men and 32 168 women aged > or =20 years who took health examination and were followed up for 5.6 years. Mortality data were analyzed according to the metabolic syndrome.
  
  
  RESULTS
  The relative risk (RR) and 95% confidence interval (CI) of cancer mortality in subjects with metabolic syndrome compared with subjects without metabolic syndrome was 1.41 (1.08-1.84) after adjustment for possible confounding factors. The association is significant only among men [RR 1.52 (1.10-2.10)], but not among women. The RRs and 95% CIs for cancer deaths in subjects with elevated body mass index, blood pressure, fasting glucose, and triglycerides were 1.36 (1.07-1.71), 1.34 (1.07-1.69), 1.45 (1.14-1.86), and 1.60 (1.26-2.02) after mutual adjustment, respectively. Upon increasing the number of metabolic risk factors to 1, 2-3, and 4-5, the RRs and 95% CIs of death from cancer were 1.32 (0.83-1.48), 1.47 (1.10-1.96), and 2.42 (1.25-4.68), respectively, with a graded fashion (P for trend < 0.005).
  
  
  CONCLUSIONS
  Our results indicate that metabolic syndrome is a risk factor for cancer-related death in Korean adults. Prevention and management of the metabolic syndrome would be needed to reduce cancer mortality.
authors.affiliation: Department of Family Medicine, Asan Medical Center, University of Ulsan College of Medicine.
authors.forename: J S
authors.initials: JS
authors.lastname: Lee
authors.affiliation: Department of Epidemiology, School of Public Health and Institute of Health and Environment, Seoul National University, Seoul, South Korea.
authors.forename: S-I
authors.initials: SI
authors.lastname: Cho
authors.affiliation: Department of Family Medicine, Asan Medical Center, University of Ulsan College of Medicine. Electronic address: hyesoon@amc.seoul.kr.
authors.forename: H S
authors.initials: HS
authors.lastname: Park
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000706:statistics & numerical data*; D001786:Blood Glucose; D001794:Blood Pressure; D015992:Body Mass Index; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications* / Q000401:mortality*; D008875:Middle Aged; D009369:Neoplasms / Q000209:etiology* / Q000401:mortality*; D012307:Risk Factors; D015996:Survival Rate; D055815:Young Adult
chemical_list: D001786:Blood Glucose