Biologically functional cationic phospholipid-gold nanoplasmonic carriers of RNA.
Biologically functional cationic phospholipid-gold nanoplasmonic carriers have been designed to simultaneously exhibit carrier capabilities, demonstrate improved colloidal stability, and show no cytotoxicity under physiological conditions. Cargo, such as RNA, DNA, proteins, or drugs, can be adsorbed onto or incorporated into the cationic phospholipid bilayer membrane. These carriers are able to retain their unique nanoscale optical properties under physiological conditions, making them particularly useful in a wide range of imaging, therapeutic, and gene delivery applications that utilize selective nanoplasmonic properties.
Lee
Somin Eunice
SE
Biomolecular Nanotechnology Center, Department of Bioengineering, University of California-Berkeley, UCSF/UCB Joint Graduate Group in Bioengineering, Berkeley, California 94720-1762, USA.
Sasaki
Darryl Y
DY
Perroud
Thomas D
TD
Yoo
Daniel
D
Patel
Kamlesh D
KD
Lee
Luke P
LP
D002412:Cations; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004337:Drug Carriers / Q000138:chemical synthesis*; D004355:Drug Stability; D018014:Gene Transfer Techniques; D006046:Gold / Q000737:chemistry*; D006801:Humans; D008027:Light; D008051:Lipid Bilayers / Q000737:chemistry*; D053768:Metal Nanoparticles; D010743:Phospholipids / Q000737:chemistry; D012313:RNA / Q000378:metabolism* / Q000494:pharmacology; D012542:Scattering, Radiation; D013501:Surface-Active Agents / Q000737:chemistry
D002412:Cations; D004337:Drug Carriers; D008051:Lipid Bilayers; D010743:Phospholipids; D013501:Surface-Active Agents; D012313:RNA; D006046:Gold