Ethanol consumption by Wistar rat dams affects selenium bioavailability and antioxidant balance in their progeny.
Ethanol consumption affects maternal nutrition, the mothers' antioxidant balance and the future health of their progeny. Selenium (Se) is a trace element cofactor of the enzyme glutathione peroxidase (GPx). We will study the effect of ethanol on Se bioavailability in dams and in their progeny. We have used three experimental groups of dams: control, chronic ethanol and pair-fed; and three groups of pups. Se levels were measured by graphite-furnace atomic absorption spectrometry. Serum and hepatic GPx activity was determined by spectrometry. We have concluded that ethanol decreased Se retention in dams, affecting their tissue Se deposits and those of their offspring, while also compromising their progeny's weight and oxidation balance. These effects of ethanol are caused by a reduction in Se intake and a direct alcohol-generated oxidation action.
Ojeda
María Luisa
ML
Department of Physiology and Zoology, Faculty of Pharmacy, Seville University, Seville, Spain. ojedamuri11@us.es
Vázquez
Beatriz
B
Nogales
Fátima
F
Murillo
María Luisa
ML
Carreras
Olimpia
O
D000428:Alcohol Drinking / Q000009:adverse effects; D000818:Animals; D000831:Animals, Newborn; D001682:Biological Availability; D001724:Birth Weight / Q000187:drug effects*; D000431:Ethanol / Q000009:adverse effects*; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood*; D006706:Homeostasis / Q000187:drug effects; D007774:Lactation; D008099:Liver / Q000201:enzymology*; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012643:Selenium / Q000378:metabolism* / Q000493:pharmacokinetics; D015430:Weight Gain / Q000187:drug effects
D000431:Ethanol; D005979:Glutathione Peroxidase; D012643:Selenium