The suggestion of a risk stratification system for febrile neutropenia in patients with hematologic disease.
We analyzed the prognostic factors from 259 cases of febrile neutropenia occurring in 137 patients with hematologic disease. Based on multivariate analysis, significant prognostic factors are recovery of neutropenia, respiratory infection, baseline serum albumin, baseline bicarbonate, baseline CRP, and CRP on the fifth day after antibiotic treatment. From these variables, we derived a predictive model for the prognosis of febrile neutropenia using baseline serum albumin, bicarbonate, and CRP, which could be easily checked before chemotherapy. Further studies in prospective setting are needed for the validation of this model.
Park
Yong
Y
Division of Hematology and Oncology, Department of Internal Medicine, College of Medicine, Korea University, Seoul, Republic of Korea.
Kim
Dae Sik
DS
Park
Seh Jong
SJ
Seo
Hee Yun
HY
Lee
Se Ryeon
SR
Sung
Hwa Jung
HJ
Park
Kyong Hwa
KH
Choi
In Keun
IK
Kim
Seok Jin
SJ
Oh
Sang Cheul
SC
Seo
Jae Hong
JH
Choi
Chul Won
CW
Kim
Byung Soo
BS
Shin
Sang Won
SW
Kim
Yeul Hong
YH
Kim
Jun Suk
JS
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000009:adverse effects*; D015415:Biomarkers / Q000032:analysis; D005260:Female; D005334:Fever; D019337:Hematologic Neoplasms / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D009503:Neutropenia / Q000139:chemically induced*; D011379:Prognosis; D012307:Risk Factors; D055815:Young Adult
D000970:Antineoplastic Agents; D015415:Biomarkers