title: Chlamydia trachomatis, Mycoplasma genitalium, Neisseria gonorrhoeae, human papillomavirus, and polyomavirus are not detectable in human tissue with epithelial ovarian cancer, borderline tumor, or benign conditions.
abstract: OBJECTIVE
  We sought to analyze the presence of the microorganisms Chlamydia trachomatis, Mycoplasma genitalium, Neisseria gonorrhoeae, human papillomavirus (HPV), and the polyomaviruses BK virus (BKV) and JC virus (JCV) in ovarian tissues of women with ovarian carcinomas, borderline tumors, and benign conditions.
  
  
  METHODS
  Ovarian tissue, snap-frozen and stored at -80 degrees C, from 186 women with benign conditions, borderline tumors, and epithelial ovarian cancer, as well as tissue from the contralateral ovary of 126 of these women, were analyzed regarding presence of C trachomatis and N gonorrhoeae (transcription mediated amplification), M genitalium (real-time polymerase chain reaction [PCR]), HPV (PCR), and BKV and JCV (PCR).
  
  
  RESULTS
  All the tissue samples studied were found negative for the microorganisms analyzed.
  
  
  CONCLUSIONS
  C trachomatis, M genitalium, N gonorrhoeae, HPV, and the polyomaviruses BKV and JCV are not detectable in ovarian tissues either from women with benign conditions and borderline tumors or from women with ovarian cancer.
authors.affiliation: Department of Clinical Science/Obstetrics and Gynecology, Umeå University, Sweden.
authors.forename: Annika
authors.initials: A
authors.lastname: Idahl
authors.forename: Eva
authors.initials: E
authors.lastname: Lundin
authors.forename: Fredrik
authors.initials: F
authors.lastname: Elgh
authors.forename: Margaretha
authors.initials: M
authors.lastname: Jurstrand
authors.forename: Jens K
authors.initials: JK
authors.lastname: Møller
authors.forename: Ingrid
authors.initials: I
authors.lastname: Marklund
authors.forename: Peter
authors.initials: P
authors.lastname: Lindgren
authors.forename: Ulrika
authors.initials: U
authors.lastname: Ottander
mesh_terms: D000328:Adult; D000368:Aged; D052685:Alphapapillomavirus / Q000302:isolation & purification; D001739:BK Virus / Q000302:isolation & purification*; D002692:Chlamydia trachomatis / Q000302:isolation & purification*; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D005831:Genital Diseases, Female / Q000821:virology*; D006801:Humans; D007577:JC Virus / Q000302:isolation & purification*; D008875:Middle Aged; D045704:Mycoplasma genitalium / Q000302:isolation & purification; D009344:Neisseria gonorrhoeae / Q000302:isolation & purification; D010051:Ovarian Neoplasms / Q000821:virology*; D010053:Ovary / Q000821:virology*; D016133:Polymerase Chain Reaction
chemical_list: D004279:DNA, Viral