title: Airway obstruction is increased in pneumocystis-colonized human immunodeficiency virus-infected outpatients.
abstract: We investigated the relationship of Pneumocystis colonization, matrix metalloprotease levels in sputum, and airway obstruction in a cohort of human immunodeficiency virus (HIV)-infected outpatients. Pneumocystis-colonized subjects had worse obstruction of airways and higher levels of matrix metalloprotease-12 in sputa, suggesting that Pneumocystis colonization may be important in HIV-associated chronic obstructive pulmonary disease.
authors.affiliation: University of Pittsburgh Medical Center, 628 NW MUH, 3459 Fifth Avenue, Pittsburgh, PA 15213, USA. morrisa@upmc.edu
authors.forename: Alison
authors.initials: A
authors.lastname: Morris
authors.forename: Travis
authors.initials: T
authors.lastname: Alexander
authors.forename: Saba
authors.initials: S
authors.lastname: Radhi
authors.forename: Lorrie
authors.initials: L
authors.lastname: Lucht
authors.forename: Frank C
authors.initials: FC
authors.lastname: Sciurba
authors.forename: Jay K
authors.initials: JK
authors.lastname: Kolls
authors.forename: Ruma
authors.initials: R
authors.lastname: Srivastava
authors.forename: Chad
authors.initials: C
authors.lastname: Steele
authors.forename: Karen A
authors.initials: KA
authors.lastname: Norris
mesh_terms: D000328:Adult; D000368:Aged; D000402:Airway Obstruction / Q000382:microbiology* / Q000473:pathology*; D015331:Cohort Studies; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008297:Male; D053508:Matrix Metalloproteinase 12 / Q000032:analysis; D008875:Middle Aged; D010045:Outpatients; D011010:Pneumocystis / Q000302:isolation & purification*; D016720:Pneumocystis Infections / Q000382:microbiology* / Q000473:pathology*; D013183:Sputum / Q000737:chemistry
chemical_list: D053508:Matrix Metalloproteinase 12