title: [PAUL procedure. A new biocompatible concept for the therapy of congenital abdominal wall defects].
abstract: Treatment of small congenital abdominal wall defects (e.g. omphalocele and gastroschisis) can be performed by direct closure. In large defects non-resorbable artificial materials (e.g. Gore-Tex) are necessary to close the fascia. The aim of this study was to find out whether a new procedure, the PAUL pocedure, might be suitable for the treatment of large abdominal wall defects. A full thickness abdominal wall defect was created in young Wistar Rats. These defects were then closed by implantation of a 1x2 cm sized piece of PTFE (Dual-Mesh), a polypropylene mesh (Prolene(R)) or by using the PAUL procedure. Over a period of 6 weeks no wound infections or hernias were monitored. In contrast to PTFE the PAUL procedure showed only minimal adhesion to the intestine and a high stability of the implanted material. A xenogenic extracellular matrix, such as that used in the PAUL procedure, may induce an immune response, which is comparable with a remodeling reaction rather than rejection. Based on these good results a large animal model study (Goettinger mini-piglets) was performed. No wound infections or hernias could be observed throughout the experiment. Control laparoscopy after 3, 6, 9, and 12 months showed only minimal adhesion to the intestine. Our results indicate that the PAUL procedure can be used easily and successfully for the therapy of congenital abdominal wall defects.
authors.affiliation: Abteilung für Kinderchirurgie und Experimentelle Chirurgie, Universitätsklinik für Allgemein-, Viszeral-, Gefäss- und Kinderchirurgie, Klinikum der Bayerischen Julius-Maximilians-Universität, Oberdürrbacher Strasse 6, 97080 Würzburg. Meyer_t@chirurgie.uni-wuerzburg.de
authors.forename: T
authors.initials: T
authors.lastname: Meyer
authors.forename: A
authors.initials: A
authors.lastname: Seifert
authors.forename: B
authors.initials: B
authors.lastname: Meyer
authors.forename: K
authors.initials: K
authors.lastname: Ulrichs
authors.forename: C-T
authors.initials: CT
authors.lastname: Germer
mesh_terms: D000818:Animals; D001705:Bioprosthesis; D004195:Disease Models, Animal; D020139:Gastroschisis / Q000473:pathology / Q000601:surgery*; D006554:Hernia, Umbilical / Q000473:pathology / Q000601:surgery*; D006801:Humans; D011126:Polypropylenes; D011138:Polytetrafluoroethylene; D011183:Postoperative Complications / Q000473:pathology / Q000517:prevention & control; D011474:Prosthesis Design; D019919:Prosthesis Implantation / Q000379:methods*; D051381:Rats; D017208:Rats, Wistar; D013526:Surgical Mesh; D013552:Swine; D013556:Swine, Miniature; D000267:Tissue Adhesions / Q000473:pathology / Q000517:prevention & control; D014945:Wound Healing / Q000502:physiology
chemical_list: D011126:Polypropylenes; D011138:Polytetrafluoroethylene