Early experience with sunitinib, combined with docetaxel, in patients with metastatic breast cancer.
Sunitinib malate (SUTENT) is an oral, multitargeted tyrosine kinase inhibitor that blocks several pathways central to angiogenesis and tumor cell proliferation and migration, including vascular endothelial growth factor receptors (VEGFRs) and platelet-derived growth factor receptors (PDGFRs). Sunitinib has demonstrated clinical activity as a single agent in patients with metastatic breast cancer and it is hypothesized that enhanced clinical benefit may be derived by combining sunitinib with chemotherapy or other targeted agents. The current report describes four patients with advanced/metastatic breast cancer who experienced clinically meaningful responses following treatment with sunitinib in combination with docetaxel.
Liljegren
Annelie
A
Karolinska Institutet and Karolinska University Hospital, SE-171 76, Stockholm, Sweden. annelie.liljegren@karolinska.se
Bergh
Jonas
J
Castany
Roser
R
D000328:Adult; D020533:Angiogenesis Inhibitors / Q000008:administration & dosage* / Q000493:pharmacokinetics; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000493:pharmacokinetics / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D018270:Carcinoma, Ductal, Breast / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D003131:Combined Modality Therapy; D000077143:Docetaxel; D005260:Female; D006801:Humans; D007211:Indoles / Q000008:administration & dosage* / Q000493:pharmacokinetics; D008113:Liver Neoplasms / Q000556:secondary; D008197:Lymph Node Excision; D008408:Mastectomy; D008875:Middle Aged; D011758:Pyrroles / Q000008:administration & dosage* / Q000493:pharmacokinetics; D000077210:Sunitinib; D043823:Taxoids / Q000008:administration & dosage* / Q000493:pharmacokinetics; D014057:Tomography, X-Ray Computed
D020533:Angiogenesis Inhibitors; D000970:Antineoplastic Agents; D007211:Indoles; D011758:Pyrroles; D043823:Taxoids; D000077143:Docetaxel; D000077210:Sunitinib