How does volume status affect BNP and troponin levels as markers of cardiovascular status in peritoneal dialysis?
Cardiac biomarkers such as brain natriuretic peptide, amino-terminal pro-B-type natriuretic peptide (NT-proBNP), and cardiac troponin provide information on cardiovascular morbidity and mortality in patients with normal renal function. In a considerable number of chronic hemodialysis patients, both biomarkers-NT-proBNP and troponin-are elevated despite the absence of cardiac ischemia. The elevation of cardiac biomarkers in chronic hemodialysis patients is of prognostic value with respect to cardiovascular morbidity and mortality. Furthermore, they can serve as tools for volume assessment for optimization of the fluid management aspect of dialysis. However, the association of both these markers in peritoneal dialysis is not clear. Therefore, the authors reviewed the literature to examine the role of these markers in peritoneal dialysis patients both as prognostic indicators as well as tools for volume assessment.
Garg
Rajeev
R
University of Missouri-Columbia, 65202, USA. rajeevgarg@sbcglobal.net
Singh
Avneet
A
Khaja
Azam
A
Martin
Alpert
A
Aggarwal
Kul
K
D015415:Biomarkers; D002318:Cardiovascular Diseases / Q000097:blood / Q000175:diagnosis; D002319:Cardiovascular System; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000097:blood*; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D010530:Peritoneal Dialysis; D011379:Prognosis; D013223:Statistics as Topic; D013318:Stroke Volume; D014336:Troponin / Q000097:blood*; D018487:Ventricular Dysfunction, Left / Q000097:blood*; D016277:Ventricular Function, Left
D015415:Biomarkers; D010446:Peptide Fragments; D014336:Troponin; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain