Reducing the mystery of neuronal differentiation.
In the developing nervous system, neural progenitors exit the cell cycle and differentiate on a precise schedule, yet the mechanisms driving this process remain poorly defined. Yan et al. (2009) now identify a thiol-redox reaction mediated by the membrane protein GDE2 and the peroxiredoxin protein Prdx1 that promotes neurogenesis.
Novitch
Bennett G
BG
Department of Neurobiology, Broad Center of Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. bnovitch@ucla.edu
Butler
Samantha J
SJ
D000818:Animals; D002454:Cell Differentiation; D055495:Neurogenesis; D009474:Neurons / Q000166:cytology*; D054464:Peroxiredoxins / Q000378:metabolism; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism; D013116:Spinal Cord / Q000166:cytology* / Q000196:embryology
D054464:Peroxiredoxins; D010727:Phosphoric Diester Hydrolases; C038133:glycerophosphodiester phosphodiesterase