title: Endoplasmic reticulum stress: an unrecognized actor in solid organ transplantation.
abstract: Endoplasmic reticulum (ER) stress is an adaptive response to the accumulation of misfolded proteins within the ER, which can trigger cell dedifferentiation and cell suicide. Increasing evidences suggest its implication in mediating allograft injury. Herein, we summarize the mechanisms of ER stress and discuss its implication in allograft injury. Increasing our understanding of the cellular and molecular mechanisms of acute and chronic allograft damages could lead to the development of new biomarkers and to the discovery of new therapeutic strategies to prevent the initiation of graft dysfunction or to promote the tissue regeneration after injury.
authors.affiliation: INSERM U775 and Université Paris Descartes, Centre Universitaire des Saints-Pères, Paris, France. nicolas.pallet@univ-paris5.fr
authors.forename: Nicolas
authors.initials: N
authors.lastname: Pallet
authors.forename: Sophie
authors.initials: S
authors.lastname: Fougeray
authors.forename: Philippe
authors.initials: P
authors.lastname: Beaune
authors.forename: Christophe
authors.initials: C
authors.lastname: Legendre
authors.forename: Eric
authors.initials: E
authors.lastname: Thervet
authors.forename: Dany
authors.initials: D
authors.lastname: Anglicheau
mesh_terms: D000818:Animals; D065095:Calcineurin Inhibitors; D002908:Chronic Disease; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D006801:Humans; D007668:Kidney / Q000473:pathology; D008954:Models, Biological; D011489:Protein Denaturation; D017510:Protein Folding; D012038:Regeneration; D015427:Reperfusion Injury; D013312:Stress, Physiological; D014180:Transplantation / Q000379:methods*; D014184:Transplantation, Homologous / Q000379:methods
chemical_list: D065095:Calcineurin Inhibitors