Determination of group a streptococcal anti-M type-specific antibody in sera of rheumatic fever patients after 45 years.
Group A streptococcal M type--specific protective antibodies-especially their persistence in humans--are incompletely understood. Such information is essential for understanding the epidemiology and pathogenesis of these infections and their sequelae and is equally crucial for producing a group A streptococcal vaccine. We studied 2 adults for type-specific antibody 45 years after they experienced documented rheumatic fever.
Bencivenga
James F
JF
Department of Pediatrics, University of Minnesota Medical School, Minneapolis, USA.
Johnson
Dwight R
DR
Kaplan
Edward L
EL
D000907:Antibodies, Bacterial / Q000097:blood*; D000942:Antigens, Bacterial / Q000276:immunology*; D001425:Bacterial Outer Membrane Proteins / Q000276:immunology*; D002352:Carrier Proteins / Q000276:immunology*; D006801:Humans; D008875:Middle Aged; D012213:Rheumatic Fever / Q000276:immunology*; D013297:Streptococcus pyogenes / Q000276:immunology*; D013997:Time Factors
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D002352:Carrier Proteins; C014689:streptococcal M protein