title: [A case of hearing loss and diffuse alveolar hemorrhage associated with microscopic polyangitis].
abstract: We report a rare case of bilateral hearing loss and diffuse alveolar hemorrhage associated with microscopic polyangitis (MPA). A 75-year-old woman complained of hearing loss. Two months later, she was admitted due to rapidly progressing dyspnea. Chest radiography and CT scan showed diffuse bilateral consolidations. Mechanical ventilation was required for respiratory insufficiency. Laboratory data demonstrated anemia and renal failure. Steroid pulse therapy and antibiotics were initiated. On day 2, bronchoalveolar lavage showed fresh blood-like fluid, which suggested diffuse alveolar hemorrhage (DAH). Serum level of myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA) was elevated. Therefore, DAH and rapidly progressive glomerulonephritis associated with MPA were diagnosed. Treatment was also performed with cyclophosphamide pulse therapy and plasmapheresis. Her pulmonary lesion improved dramatically. We emphasize the effectiveness of bronchoalveolar lavage for prompt and accurate diagnoses. Moreover, this case report also suggests that early cyclophosphamide therapy and plasmapheresis may be an effective treatment for MPA with diffuse alveolar hemorrhage. In contrast, hearing loss did not improve after therapy. Some cases reported hearing loss as a rare symptom of MPA. We also suspect that hearing loss may be a complication of MPA. We reported this case because there has been no description of hearing loss accompanying DAH associated with MPA.
authors.affiliation: Department of Internal Medicine, Kitakyusyu General Hospital.
authors.forename: Keitaro
authors.initials: K
authors.lastname: Omori
authors.forename: Teppei
authors.initials: T
authors.lastname: Hoshino
authors.forename: Hakubun
authors.initials: H
authors.lastname: Hiramoto
authors.forename: Hideto
authors.initials: H
authors.lastname: Oshita
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Shoda
authors.forename: Naoki
authors.initials: N
authors.lastname: Okamoto
authors.forename: Yukikazu
authors.initials: Y
authors.lastname: Awaya
mesh_terms: D000368:Aged; D018893:Bronchoalveolar Lavage; D005260:Female; D006312:Hearing Loss, Bilateral / Q000209:etiology*; D006470:Hemorrhage / Q000209:etiology*; D006801:Humans; D008171:Lung Diseases / Q000209:etiology* / Q000628:therapy; D055953:Microscopic Polyangiitis / Q000150:complications*; D011650:Pulmonary Alveoli