Investigation of the H(+)-myo-inositol transporter (HMIT) as a neuronal regulator of phosphoinositide signalling.
Phosphoinositide signalling regulates a series of important neuronal processes that are thought to be altered in mood disorders. Furthermore, mood-stabilizing drugs inhibit key enzymes that regulate phosphoinositide production and alter neuronal growth cone morphology in an inositol-reversible manner. Inositol is taken up by neurons from the extracellular fluid, presumably via membrane transporters; it can also be synthesized by the enzyme MIP-synthase (myo-inositol-1-phosphate synthase) and, in addition, it is generated by inositol phospholipid hydrolysis. The neuronal-specific HMIT (H(+)-myo-inositol transporter) represents a potential regulator of inositol signalling in neurons that warrants further investigation.
Di Daniel
Elena
E
Synaptic Plasticity and Neural Network Dynamics DPU, Neurosciences Centre of Excellence for Drug Discovery, GlaxoSmithKline, New Frontiers Science Park, Third Avenue, Harlow, Essex, UK. Elena.2.DiDaniel@gsk.com
Kew
James N
JN
Maycox
Peter R
PR
D000818:Animals; D018692:Antimanic Agents / Q000494:pharmacology; D001921:Brain / Q000378:metabolism; D002220:Carbamazepine / Q000494:pharmacology; D051246:Glucose Transport Proteins, Facilitative / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007294:Inositol / Q000378:metabolism; D018020:Lithium Compounds / Q000494:pharmacology; D026901:Membrane Transport Proteins / Q000378:metabolism; D009474:Neurons / Q000166:cytology / Q000378:metabolism; D010716:Phosphatidylinositols / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D014635:Valproic Acid / Q000494:pharmacology
D018692:Antimanic Agents; D051246:Glucose Transport Proteins, Facilitative; D018020:Lithium Compounds; D026901:Membrane Transport Proteins; D010716:Phosphatidylinositols; C437315:SLC2A13 protein, human; D002220:Carbamazepine; D007294:Inositol; D014635:Valproic Acid