Multicomponent reactions of dimethyl methoxymalonate and dialkyl acetylenedicarboxylate in the presence of N-nucleophiles: one-pot synthesis of 2H-pyridinyl-2-butenedioates in water.
An efficient synthesis of 2H-pyridinyl-2-butenedioate derivatives via reaction of dimethyl methoxymalonate and dialkyl acetylenedicarboxylate in the presence of N-nucleophiles in water as a solvent is described.
Khalilzadeh
Mohammad A
MA
Chemistry Department, Islamic Azad University, Qaemshahr Branch, Mazandaran, Iran. m.khalilzadeh@hotmail.com
Hossaini
Zinatossadat
Z
Kharian
Samaneh
S
D000480:Alkynes / Q000138:chemical synthesis* / Q000737:chemistry; D002625:Chemistry, Organic / Q000379:methods*; D007546:Isoquinolines / Q000737:chemistry; D008314:Malonates / Q000138:chemical synthesis* / Q000737:chemistry; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry; D014867:Water / Q000737:chemistry*
D000480:Alkynes; D007546:Isoquinolines; D008314:Malonates; D011725:Pyridines; D014867:Water; C022918:acetylenedicarboxylic acid dimethyl ester