title: Antilonomic effects of Brazilian brown seaweed extracts.
abstract: The aim of this work was to investigate the hemolysis and blood clotting activity of Lomonia obliqua venom and the ability of some Brazilian marine algal extracts (Canistrocarpus cervicornis, Stypopodium zonale and Dictyota pfaffi) to antagonize such biological activities. L. obliqua caterpillars are dangerous to human beings and envenomation symptoms are characterized by hemorrhagic, hemolytic and blood clotting disorders, and acute renal failure, which sometimes lead to the death of the victims. Through in vitro experiments we have shown that L. obliqua venom is able to clot human plasma and hemolize human erythrocytes and that the coagulation activity of the venom is inhibited by the extracts of C. cervicornis, S. zonale and D. pfaffi. In contrast, C. cervicornis and S. zonale extracts did not inhibit the hemolytic activity of L. oblqua, as did the extract of D. pfaffi. These finding indicate that marine algae may be used as antivenoms or may contribute to the development of compounds with antilonomic effects.
authors.affiliation: Departamento de Biologia Molecular e Celular, Instituto de Biologia, Universidade Federal Fluminense, Niterói, RJ, Brazil.
authors.forename: Thaisa Francielle Souza
authors.initials: TF
authors.lastname: Domingos
authors.forename: Carla
authors.initials: C
authors.lastname: Carvalho
authors.forename: Laura de Andrade
authors.initials: Lde A
authors.lastname: Moura
authors.forename: Valéria Laneuville
authors.initials: VL
authors.lastname: Teixeira
authors.forename: Renato Crespo
authors.initials: RC
authors.lastname: Pereira
authors.forename: Everson Miguel
authors.initials: EM
authors.lastname: Bianco
authors.forename: Wilton José
authors.initials: WJ
authors.lastname: Ferreira
authors.forename: Carlos José Brito
authors.initials: CJ
authors.lastname: Ramos
authors.forename: Ana Luiza Palhares
authors.initials: AL
authors.lastname: de Miranda
authors.forename: Paulo Assis
authors.initials: PA
authors.lastname: Melo
authors.forename: Jorge Almeida
authors.initials: JA
authors.lastname: Guimarães
authors.forename: André Lopes
authors.initials: AL
authors.lastname: Fuly
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced; D000818:Animals; D001778:Blood Coagulation Disorders / Q000139:chemically induced; D001938:Brazil; D004912:Erythrocytes / Q000187:drug effects; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D007814:Larva; D009036:Moths / Q000737:chemistry / Q000254:growth & development; D000459:Phaeophyceae / Q000737:chemistry*; D012624:Seaweed / Q000737:chemistry*; D014688:Venoms / Q000302:isolation & purification / Q000633:toxicity*
chemical_list: D014688:Venoms