Acute cholestatic hepatitis induced by fenofibrate.
We report a case of acute liver injury probably due to fenofibrate. A 50-year-old female without a history of liver disease developed cholestatic hepatitis during her second week of fenofibrate treatment. Laboratory tests on admission showed serum bilirubin 534.0 mcmol/L (conjugated 444.0), alkaline phosphatase (AP) 8.76, gamma-glutamyl traspeptidase (GGT) 20.92, alanine aminotransferase (ALT) 2.6, aspartate aminotransferase (AST) 3.64 mckat/L. Fenofibrate withdrawal and ursodeoxycholic acid (750 mg daily) administration was rapidly followed by a favourable outcome.
Hajdu
D
D
Department of Pharmacology, Faculty of Medicine and Dentistry of Palacky University and University Hospital, Olomouc, Czech Republic.
Aiglová
K
K
Vinklerová
I
I
Urbánek
K
K
D000208:Acute Disease; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D002780:Cholestasis, Intrahepatic / Q000139:chemically induced*; D005260:Female; D011345:Fenofibrate / Q000009:adverse effects*; D006801:Humans; D000960:Hypolipidemic Agents / Q000009:adverse effects*; D008875:Middle Aged
D000960:Hypolipidemic Agents; D011345:Fenofibrate