title: Antioxidant and antibacterial activities of the leaf essential oils of Himalayan Lauraceae species.
abstract: The leaf essential oils from seven Himalayan Lauraceae species viz. Neolitsea pallens, Lindera pulcherrima, Dodecadenia grandiflora, Persea duthiei, Persea odoratissima, Persea gamblei and Phoebe lanceolata exhibited potent antioxidant and antibacterial activities. The in vitro antioxidant activity was assessed by using beta-carotene bleaching assay, reducing power, DPPH radical scavenging and inhibition of lipid peroxidation methods. The oils of D. grandiflora and L. pulcherrima showed a potent free radical scavenging activity as evidenced by low IC(50) value for DPPH radical (0.032 mg/ml and 0.087 mg/ml, respectively) and inhibition of lipid peroxidation (in between IC(50)=0.44 mg/ml and IC(50)=0.74 mg/ml, respectively). The oils were tested against three Gram negative (Escherichia coli, Salmonella enterica enterica and Pasturella multocida) and one Gram positive (Staphylococcus aureus) bacteria at different concentrations using disc diffusion and tube dilution methods. The inhibition zones (IZ) and MIC values for bacterial strains were in the range of 8.7-22.0mm and 3.90-31.25 microl/ml, respectively.
authors.affiliation: Department of Chemistry, Kumaun University, Nainital 263002, India.
authors.forename: Subhash C
authors.initials: SC
authors.lastname: Joshi
authors.forename: Arti R
authors.initials: AR
authors.lastname: Verma
authors.forename: Chandra S
authors.initials: CS
authors.lastname: Mathela
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D001713:Biphenyl Compounds / Q000737:chemistry; D007194:India; D007202:Indicators and Reagents; D019770:Lauraceae / Q000737:chemistry*; D019787:Linoleic Acid / Q000737:chemistry; D015227:Lipid Peroxidation / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D009822:Oils, Volatile / Q000494:pharmacology*; D010084:Oxidation-Reduction; D010851:Picrates / Q000737:chemistry; D019207:beta Carotene / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D000975:Antioxidants; D001713:Biphenyl Compounds; D007202:Indicators and Reagents; D009822:Oils, Volatile; D010851:Picrates; D019207:beta Carotene; D019787:Linoleic Acid; C004931:1,1-diphenyl-2-picrylhydrazyl