title: Use of 660-nm diode laser in the prevention and treatment of human oral mucositis induced by radiotherapy and chemotherapy.
abstract: OBJECTIVE
  The aim of this multidisciplinary study was to evaluate quantitatively and qualitatively the effect of a 660-nm diode laser in the prevention and treatment of human oral mucositis (OM) in patients suffering from head and neck cancer who had undergone radiotherapy and chemotherapy.
  
  
  BACKGROUND
  OM is a severe oral lesion resulting from the toxic effects of treatment for cancer in the head and neck region. Low-level laser therapy is indicated to prevent and treat this oral complication and may be used alone or in association with conventional drug treatment, producing pain relief and wound repair.
  
  
  METHODS
  This study included 72 patients with head and neck cancer treated at the Cancer Hospital of Mato-Grosso, Brazil, and divided into a control group (C; n = 36) and a laser group (L; n = 36). Laser therapy was performed in combination with radiotherapy and chemotherapy twice a week using a diode laser (lambda = 660 nm, power = 30 mW, spot size = 2 mm, energy = 2 J per point).
  
  
  RESULTS
  Statistically significant differences were observed between the two groups. Patients in group L usually did not present with OM or pain, but all patients in group C presented with OM ranging from Level I to III associated with pain. This difference was significant from week 1 on, increased until week 4 and remained stable up to week 7.
  
  
  CONCLUSIONS
  Laser therapy was effective in preventing and treating oral effects induced by radiotherapy and chemotherapy, thus improving the patient's quality of life.
authors.affiliation: Photobiology and Lasertherapy Center, Vale do Paraíba University, São Jose dos Campos, SP, Brazil.
authors.forename: Taís
authors.initials: T
authors.lastname: Zanin
authors.forename: Fatima
authors.initials: F
authors.lastname: Zanin
authors.forename: Artur Aburad
authors.initials: AA
authors.lastname: Carvalhosa
authors.forename: Paulo Henrique de Souza
authors.initials: PH
authors.lastname: Castro
authors.forename: Marcos Tadeu
authors.initials: MT
authors.lastname: Pacheco
authors.forename: Iriana Carla Junqueira
authors.initials: IC
authors.lastname: Zanin
authors.forename: Aldo
authors.initials: A
authors.lastname: Brugnera
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006258:Head and Neck Neoplasms / Q000188:drug therapy / Q000532:radiotherapy; D006801:Humans; D054023:Lasers, Semiconductor / Q000627:therapeutic use*; D028022:Low-Level Light Therapy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011832:Radiation Injuries / Q000517:prevention & control* / Q000532:radiotherapy*; D013280:Stomatitis / Q000139:chemically induced / Q000209:etiology / Q000517:prevention & control* / Q000532:radiotherapy*