Surgery-assisted reproductive technology hybrid therapy: a reproductive procedure for an infertile woman of late reproductive age with multiple myomas.
OBJECTIVE
To produce a successful pregnancy in a 38-year-old infertile patient with relapsed myoma using a technique we refer to as 'surgery-assisted reproductive technology (ART) hybrid therapy' because it combines ART for cryopreservation of in vitro fertilized eggs with reproductive surgery.


METHODS
A 38-year-old nulliparous woman who had undergone abdominal myomectomy and in whom magnetic resonance imaging showed multiple myomas was treated at our University-affiliated hospital and outpatient clinic. Blastocysts were cryopreserved during the preoperative period. Laparoscopic myomectomy was performed after preoperative treatment with a GnRH agonist. Ten months after the operation, the youngest cryopreserved blastocyst was transferred into the uterus and implanted successfully.


RESULTS
Treatment resulted in successful implantation and pregnancy. In January 2008, the course of pregnancy had been uneventful and the patient gave birth to a male infant weighing 2998 grams by cesarean section at 37 weeks of gestation.


CONCLUSIONS
We have treated eight patients using hybrid therapy with encouraging results, and we describe these cases herein briefly.
Kuroda
Keiji
K
Department of Obstetrics and Gynaecology, Juntendo University School of Medicine, Tokyo, Japan. arthur@juntendo.ac.jp
Takeuchi
Hiroyuki
H
Kitade
Mari
M
Kikuchi
Iwaho
I
Kumakiri
Jun
J
Kobayashi
Yuko
Y
Kobori
Hiroyuki
H
Kuroda
Masako
M
Itagaki
Kazuko
K
Machida
Mai
M
Takeda
Satoru
S
D000328:Adult; D015925:Cryopreservation; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007247:Infertility, Female / Q000628:therapy*; D007889:Leiomyoma / Q000601:surgery*; D008297:Male; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000601:surgery*; D027724:Reproductive Techniques, Assisted; D014594:Uterine Neoplasms / Q000601:surgery*