title: Genetic diversity of HIV type 1 along the coastal strip of Kenya.
abstract: A study on the genetic diversity of HIV-1 subtypes present along the coastal strip of Kenya, i.e., Kilifi, Mombasa, Msambweni, and Malindi districts, was carried out. DNA sequences for regions encoding a portion of the env-gp41 region of the virus were generated by PCR and sequenced directly. Eighty six samples that were successfully sequenced were analyzed. From the analysis, 86% (74) were subtype A1, 5% (4) were subtype C, 8% (7) were subtype D, and 1% (1) was subtype G. This study shows that HIV-1 subtype A1 is the most dominant subtype in circulation in this region.
authors.affiliation: Kenya Medical Research Institute, Nairobi, Kenya. skhamadi@kemri.org
authors.forename: Samoel A
authors.initials: SA
authors.lastname: Khamadi
authors.forename: Raphael W
authors.initials: RW
authors.lastname: Lihana
authors.forename: Saida
authors.initials: S
authors.lastname: Osman
authors.forename: Joseph
authors.initials: J
authors.lastname: Mwangi
authors.forename: Joseph
authors.initials: J
authors.lastname: Muriuki
authors.forename: Nancy
authors.initials: N
authors.lastname: Lagat
authors.forename: Joyceline
authors.initials: J
authors.lastname: Kinyua
authors.forename: Matilu
authors.initials: M
authors.lastname: Mwau
authors.forename: Sheila
authors.initials: S
authors.lastname: Kageha
authors.forename: Vincent
authors.initials: V
authors.lastname: Okoth
authors.forename: Washington
authors.initials: W
authors.lastname: Ochieng
authors.forename: Fredrick A
authors.initials: FA
authors.lastname: Okoth
mesh_terms: D016000:Cluster Analysis; D014644:Genetic Variation; D005838:Genotype; D015700:HIV Envelope Protein gp41 / Q000235:genetics; D015658:HIV Infections / Q000821:virology*; D015497:HIV-1 / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D007630:Kenya; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D017422:Sequence Analysis, DNA; D017385:Sequence Homology
chemical_list: D015700:HIV Envelope Protein gp41