title: HTR2A gene variation is involved in antidepressant treatment response.
abstract: Two serotonin 2A receptor (HTR2A) SNPs recently reported to be associated with antidepressant treatment response in STARD (rs7997012; rs1928040) were analyzed for association with treatment response in two independent Caucasian samples of patients with a Major Depressive Episode. In the combined sample (n=637) SNP rs7997012 was significantly associated with remission after five weeks providing first replicative support for the initial finding, with, however, an inverse allelic association as compared to the STARD sample.
authors.affiliation: Max Planck Institute of Psychiatry, Munich, Germany.
authors.forename: Susanne
authors.initials: S
authors.lastname: Lucae
authors.forename: Marcus
authors.initials: M
authors.lastname: Ising
authors.forename: Sonja
authors.initials: S
authors.lastname: Horstmann
authors.forename: Bernhard T
authors.initials: BT
authors.lastname: Baune
authors.forename: Volker
authors.initials: V
authors.lastname: Arolt
authors.forename: Bertram
authors.initials: B
authors.lastname: Müller-Myhsok
authors.forename: Florian
authors.initials: F
authors.lastname: Holsboer
authors.forename: Katharina
authors.initials: K
authors.lastname: Domschke
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D000928:Antidepressive Agents / Q000627:therapeutic use*; D003865:Major Depressive Disorder / Q000188:drug therapy* / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010597:Pharmacogenetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011569:Psychiatric Status Rating Scales; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics
chemical_list: D000928:Antidepressive Agents; D044402:Receptor, Serotonin, 5-HT2A