[Roles of PPARs in the origin of metabolic disturbances in children with low birth weight (below 2500 g)].
Children, who are born with low birth weight (less than 2500 g) are known to have an increased risk of developing metabolic syndrome in later live. PPAR could play a regulatory role in the pathogenesis of hyperlipidemia disturbance and a modulatory role in the control of inflammatory response. Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily of lig and -dependent transcription factors with pleiotropic effects on lipid metabolism, glucose homeostasis, cell proliferation, control of inflammation and atherosclerosis. Three isoforms of PPAR, i.e. a, p, y have been identified and are differentially expressed in various tissues and play different metabolic functions. In this review, the roles of PPAR and their implications in the control of vascular inflammation and atherosclerosis are discussed, especially in the group of risk developing metabolic syndrome -children with low birth weight (below 2500 g).
Barg
Ewa
E
Klinika Endokrynologii i Diabetologii Wieku Rozwojowego Akademii Medycznej we Wrocławiu, Wrocław. ebarg@dilnet.wroc.pl
D050197:Atherosclerosis / Q000378:metabolism; D006801:Humans; D006949:Hyperlipidemias / Q000378:metabolism; D007230:Infant, Low Birth Weight / Q000378:metabolism*; D007231:Infant, Newborn; D024821:Metabolic Syndrome / Q000378:metabolism*; D047492:Peroxisome Proliferator-Activated Receptors / Q000378:metabolism*; D014657:Vasculitis / Q000378:metabolism
D047492:Peroxisome Proliferator-Activated Receptors