title: Hydroxyespintanol and schefflerichalcone: two new compounds from Uvaria scheffleri.
abstract: A chemical investigation of the petroleum ether extract and chloroform extract of the root of Uvaria scheffleri Diels (Annonaceae) led to the isolation of two new compounds, named hydroxyespintanol (1) and schefflerichalcone (2), together with eight known compounds (3-10). The structural elucidation of compounds 1 and 2 by spectroscopic studies is described. The cytotoxicity of the isolated compounds against human promyelocytic leukemia HL-60 cells was studied. Among these, 2'-hydroxy-3',4',6'-trimethoxychalcone (5) exhibited cytotoxicity (IC(50) 12 microM), and espintanol (3), which was the main ingredient, also showed some cytotoxicity (IC(50) 44 microM).
authors.affiliation: Department of Natural Medicinal Chemistry, Kobe Pharmaceutical University, 4-19-1 Motoyamakita-machi, Higashinada-ku, Kobe, Japan.
authors.forename: Momoyo
authors.initials: M
authors.lastname: Ichimaru
authors.forename: Noriyoshi
authors.initials: N
authors.lastname: Nakatani
authors.forename: Masataka
authors.initials: M
authors.lastname: Moriyasu
authors.forename: Yumi
authors.initials: Y
authors.lastname: Nishiyama
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kato
authors.forename: Simon G
authors.initials: SG
authors.lastname: Mathenge
authors.forename: Francis D
authors.initials: FD
authors.lastname: Juma
authors.forename: Patrick B
authors.initials: PB
authors.lastname: ChaloMutiso
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D047188:Chalcones / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D018922:HL-60 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D015473:Leukemia, Promyelocytic, Acute / Q000188:drug therapy*; D010666:Phenylpropionates / Q000302:isolation & purification / Q000494:pharmacology; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D018517:Plant Roots; D012997:Solvents / Q000737:chemistry; D013057:Spectrum Analysis; D031046:Uvaria / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D047188:Chalcones; D010666:Phenylpropionates; D010936:Plant Extracts; D012997:Solvents; C548217:hydroxyespintanol; C548218:schefflerichalcone