title: Protein kinase and phosphatase signaling in Mycobacterium tuberculosis physiology and pathogenesis.
abstract: Mycobacterium tuberculosis (Mtb), the etiological agent of tuberculosis (TB), evades the antimicrobial defenses of the host and survives within the infected individual through a complex set of strategies. These include active prevention of host cellular killing processes as well as overwhelming adaptive gene expression. In the past decade, we have gained an increased understanding of how mycobacteria not only have the ability to adapt to a changing host environment but also actively interfere with the signaling machinery within the host cell to counteract or inhibit parts of the killing apparatus employed by the macrophage. Mtb is able to sense its environment via a set of phospho-signaling proteins which mediate its response and interaction with the host in a coordinated manner. In this review, we summarize the current knowledge about selected Mtb serine, threonine, and tyrosine kinase and phosphatase signaling proteins, focusing on the protein kinases, PknG and PtkA, and the protein phosphatase, PtpA.
authors.affiliation: Department of Microbiology, University of British Columbia, Vancouver, British Columbia, Canada V5Z 3J5.
authors.forename: Joseph
authors.initials: J
authors.lastname: Chao
authors.forename: Dennis
authors.initials: D
authors.lastname: Wong
authors.forename: Xingji
authors.initials: X
authors.lastname: Zheng
authors.forename: Valerie
authors.initials: V
authors.lastname: Poirier
authors.forename: Horacio
authors.initials: H
authors.lastname: Bach
authors.forename: Zakaria
authors.initials: Z
authors.lastname: Hmama
authors.forename: Yossef
authors.initials: Y
authors.lastname: Av-Gay
mesh_terms: D001426:Bacterial Proteins / Q000378:metabolism*; D009169:Mycobacterium tuberculosis / Q000201:enzymology* / Q000472:pathogenicity*; D010749:Phosphoprotein Phosphatases / Q000378:metabolism*; D011494:Protein Kinases / Q000378:metabolism*; D014376:Tuberculosis / Q000201:enzymology*
chemical_list: D001426:Bacterial Proteins; D011494:Protein Kinases; D010749:Phosphoprotein Phosphatases