Synthesis of 2-deoxy-hexopyranosyl derivatives of uridine as donor substrate analogues for glycosyltransferases.
A series of 2-deoxy-hexopyranosyl derivatives of uridine have been synthesized as analogues of UDP-sugar. These compounds were tested as inhibitors against bovine beta-1,4-galactosyltransferase I in fluorescent assays and showed no significant inhibition.
Wandzik
Ilona
I
Silesian University of Technology, Faculty of Chemistry, Department of Organic Chemistry, Bioorganic Chemistry and Biotechnology, 44-100 Gliwice, Poland. ilona.wandzik@polsl.pl
Bieg
Tadeusz
T
Czaplicka
Marianna
M
D000818:Animals; D002417:Cattle; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry; D005700:Galactosyltransferases / Q000037:antagonists & inhibitors / Q000378:metabolism; D016695:Glycosyltransferases / Q000378:metabolism*; D013379:Substrate Specificity; D014539:Uridine Diphosphate Sugars / Q000138:chemical synthesis* / Q000737:chemistry
D004791:Enzyme Inhibitors; D014539:Uridine Diphosphate Sugars; D016695:Glycosyltransferases; D005700:Galactosyltransferases