Protective potentials of a plant extract (Lycopodium clavatum) on mice chronically fed hepato-carcinogens.
Chronic feeding of carcinogens p-dimethylamino azobenzene (initiator) and phenobarbital (promoter) for 90 and 120 days elevated activities of acid and alkaline phosphatases, levels of blood glucose and cortisol and decreased the activities of glutathione reductase, succinate dehydrogenase, and blood cholesterol and hemoglobin contents, and levels of serum estradiol and testosterone in mice. Levels of these biomarkers in both liver and spleen tissues were positively altered along with a significant reduction of tumor incidence in liver of carcinogen intoxicated mice treated with spore extract of Lycopodium clavatum. The results validate the use of this plant extract in complementary and alternative medicines against hepato-toxicity.
Pathak
Surajit
S
Department of Zoology, Cytogenetics and Molecular Biology Laboratory, University of Kalyani, Kalyani, India.
Banerjee
Antara
A
Paul
Saili
S
Khuda-Bukhsh
Anisur Rahman
AR
D000135:Acid Phosphatase / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D002273:Carcinogens / Q000037:antagonists & inhibitors / Q000633:toxicity; D005260:Female; D005980:Glutathione Reductase / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000503:physiopathology; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000503:physiopathology / Q000517:prevention & control; D032502:Lycopodium; D008297:Male; D008519:Medicine, Traditional; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology; D013385:Succinate Dehydrogenase / Q000378:metabolism
D002273:Carcinogens; D010936:Plant Extracts; D013385:Succinate Dehydrogenase; D005980:Glutathione Reductase; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase