Evidence for an interaction between age at first drink and genetic influences on DSM-IV alcohol dependence symptoms.
BACKGROUND
Research suggests that individuals who start drinking at an early age are more likely to subsequently develop alcohol dependence. Twin studies have demonstrated that the liability to age at first drink and to alcohol dependence are influenced by common genetic and environmental factors, however, age at first drink may also environmentally mediate increased risk for alcohol dependence. In this study, we examine whether age at first drink moderates genetic and environmental influences, via gene x environment interactions, on DSM-IV alcohol dependence symptoms.


METHODS
Using data on 6,257 adult monozygotic and dizygotic male and female twins from Australia, we examined the extent to which age at first drink (i) increased mean alcohol dependence symptoms and (ii) whether the magnitude of additive genetic, shared, and nonshared environmental influences on alcohol dependence symptoms varied as a function of decreasing age. Twin models were fitted in Mx.


RESULTS
Risk for alcohol dependence symptoms increased with decreasing age at first drink. Heritable influences on alcohol dependence symptoms were considerably larger in those who reported an age at first drink prior to 13 years of age. In those with later onset of alcohol use, variance in alcohol dependence was largely attributable to nonshared environmental variance (and measurement error). This evidence for unmeasured gene x measured environment interaction persisted even when controlling for the genetic influences that overlapped between age at first drink and alcohol dependence symptoms.


CONCLUSIONS
Early age at first drink may facilitate the expression of genes associated with vulnerability to alcohol dependence symptoms. This is important to consider, not only from a public health standpoint, but also in future genomic studies of alcohol dependence.
Agrawal
Arpana
A
Department of Psychiatry, Washington University School of Medicine, 660 S. Euclid, St. Louis, MO 63110, USA. arpana@wustl.edu
Sartor
Carolyn E
CE
Lynskey
Michael T
MT
Grant
Julia D
JD
Pergadia
Michele L
ML
Grucza
Richard
R
Bucholz
Kathleen K
KK
Nelson
Elliot C
EC
Madden
Pamela A F
PA
Martin
Nicholas G
NG
Heath
Andrew C
AC
D000328:Adult; D017668:Age of Onset; D000428:Alcohol Drinking / Q000235:genetics* / Q000523:psychology*; D000437:Alcoholism / Q000235:genetics* / Q000523:psychology*; D001315:Australia; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007206:Individuality; D008297:Male; D008957:Models, Genetic; D011569:Psychiatric Status Rating Scales; D012307:Risk Factors; D012931:Social Environment; D016019:Survival Analysis; D055815:Young Adult