A case report and review of the literature: ciprofloxacin resistant Salmonella enterica serovar Typhi in India.
BACKGROUND
Enteric fever is a major public health problem in India. The current treatment of choice is the fluoroquinolones.


METHODS
The minimum inhibitory concentration (MIC) of ciprofloxacin was determined by E-test, HIMEDIA HiComb MIC test and agar dilution.


RESULTS
An isolate of Salmonella enterica serovar Typhi (S. Typhi) from a case of enteric fever gave a ciprofloxacin MIC of 64 microg/ml.


CONCLUSIONS
To our knowledge there have been no reports of such high-level resistance to ciprofloxacin in S. Typhi from southern India. HIMEDIA HiComb MIC test method is an alternative to the E-test. Ciprofloxacin resistant typhoid fever responds to treatment with ceftriaxone.
Harish
Belgode Narasimha
BN
Department of Microbiology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry-605006, India. drbnharish@yahoo.com
Menezes
Godfred Antony
GA
Sarangapani
Kengamuthu
K
Parija
Subhash Chandra
SC
D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002939:Ciprofloxacin / Q000627:therapeutic use*; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D007194:India; D008297:Male; D008826:Microbial Sensitivity Tests; D012485:Salmonella typhi / Q000187:drug effects* / Q000302:isolation & purification; D014435:Typhoid Fever / Q000097:blood / Q000188:drug therapy / Q000382:microbiology*; D055815:Young Adult
D000900:Anti-Bacterial Agents; D002939:Ciprofloxacin