Alternative I-D exchange reaction on pyrimidine and purine nuclei mediated by tributyltin hydride using THF-d8 as a deuterium source.
A novel method for the regioselective deuteration of pyrimidine and purine rings mediated by Bu(3)SnH using THF-d(8) as a deuterium source on the basis of a radical reaction was developed.
Mutsumi
Tomonobu
T
Chemical Technology Laboratory, Taiho Pharmaceutical Co, Ltd, Kodama-gun, Saitama 367-0241, Japan. t-mutsumi@taiho.co.jp
Maruhashi
Kazuo
K
Monguchi
Yasunari
Y
Sajiki
Hironao
H
D041961:Deuterium Exchange Measurement; D011687:Purines / Q000737:chemistry*; D011743:Pyrimidines / Q000737:chemistry*; D014220:Trialkyltin Compounds / Q000737:chemistry*
D011687:Purines; D011743:Pyrimidines; D014220:Trialkyltin Compounds; C011559:tributyltin; C030986:pyrimidine; C030985:purine