title: Proteolysis of sigmaS (RpoS) and the general stress response in Escherichia coli.
abstract: The sigma(S) (RpoS) subunit of RNA polymerase is the master regulator of the general stress response in Escherichia coli. Regulation of sigma(S) occurs at the levels of transcription, translation, proteolysis and protein activity. As sigma(S) has become a paradigm for regulated proteolysis in bacteria, this review summarizes our current knowledge about the molecular mechanisms and multiple signal integration in sigma(S) degradation.
authors.affiliation: Institut für Biologie, Mikrobiologie, Freie Universität Berlin, Königin-Luise-Str. 12-16, 14195 Berlin, Germany. rhenggea@zedat.fu-berlin.de
authors.forename: Regine
authors.initials: R
authors.lastname: Hengge
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D055162:Biocatalysis; D004268:DNA-Binding Proteins / Q000378:metabolism; D012321:DNA-Directed RNA Polymerases / Q000235:genetics / Q000378:metabolism; D049071:Endopeptidase Clp / Q000378:metabolism; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism*; D029968:Escherichia coli Proteins / Q000235:genetics / Q000378:metabolism*; D015964:Gene Expression Regulation, Bacterial; D012808:Sigma Factor / Q000235:genetics / Q000378:metabolism*; D013312:Stress, Physiological / Q000235:genetics*; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D004268:DNA-Binding Proteins; D029968:Escherichia coli Proteins; D012808:Sigma Factor; D014157:Transcription Factors; C098923:rssB protein, E coli; C069567:sigma factor KatF protein, Bacteria; D012321:DNA-Directed RNA Polymerases; C483573:ClpXP protease, E coli; D049071:Endopeptidase Clp