Use of short echo time two-dimensional 1H-magnetic resonance spectroscopy in temporal lobe epilepsy with negative magnetic resonance imaging findings.
We evaluated short echo time two-dimensional 1H magnetic resonance spectroscopy (2D-1HMRS) with the point-resolved spatial selection (PRESS) protocol in temporal lobe epilepsy (TLE) patients with negative magnetic resonance imaging (MRI) findings and described the characteristics of 2D-(1)HMRS in the epileptic focus. Thirty-eight TLE patients with negative conventional MRI findings and 10 healthy controls were studied by 2D-1HMRS. A 128-channel prolonged video-electroencephalographic (EEG) method was used as the standard for epileptogenic focus localization to evaluate N-acetyl aspartate/(choline + creatine + phosphocreatine) (NAA/[Cho + Cr-PCr]), glutamate + glutamine/creatine (Glx/Cr-PCr) and myo-inositol/Cr-PCr ratios in patients with negative MRI findings. The 2D-1HMRS showed that 32/38 patients and all healthy controls had stable baselines and good signal-to-noise ratios. Compared with the healthy controls, 32 patients showed abnormal NAA/(Cho + Cr-PCr) ratios in the hippocampus and, in 25 of these patients, focus lateralization agreed with the EEG. It is concluded that short echo time 2D-1HMRS with the PRESS protocol can help find abnormalities in lateralization of temporal epilepsy in patients with negative MRI findings.
Shen
J
J
Department of Radiology, Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. shengarlin@sina.com
Zhang
L
L
Tian
X
X
Liu
J
J
Ge
X
X
Zhang
X
X
D000293:Adolescent; D000328:Adult; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D002794:Choline / Q000378:metabolism; D003401:Creatine / Q000378:metabolism; D004569:Electroencephalography; D004833:Epilepsy, Temporal Lobe / Q000175:diagnosis* / Q000378:metabolism; D005240:Feasibility Studies; D005260:Female; D005973:Glutamine / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007294:Inositol / Q000378:metabolism; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011522:Protons; D055815:Young Adult
D011522:Protons; D005973:Glutamine; D001224:Aspartic Acid; D007294:Inositol; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline