[A case of rectal cancer with liver metastases successfully treated with modified FOLFOX6 therapy].
We report a case of a 71-year-old male with rectal cancer accompanied by liver metastases. Abdominal CT scan revealed a hepatic tumor (S2, 3) about 4 cm in diameter. We performed a Mile's operation and planned to resect the liver metastases after chemotherapy of modified FOLFOX6(mFOLFOX6)regimen: l-leucovorin (200 mg/m2) and oxaliplatin (85 mg/m/2) were given as a 2-hour infusion followed by bolus injection of 5-FU 400 mg/m2 and a 46-hour infusion 5-FU 2,400 mg/m2 every 2 weeks. An abdominal CT scan 6 months later demonstrated regression of the liver metastases. Hepatectomy was performed after chemotherapy, and no viable tumor cells were seen.
Shoji
Tuyoshi
T
Dept. of Surgery, Shizuoka Municipal Shimizu Hospital.
Takahashi
Yoshiaki
Y
Matsuda
Iwao
I
Suzuki
Kunihito
K
Misumi
Keizo
K
Taniguchi
Masami
M
Yamazaki
Masanori
M
Yonekawa
Hajime
H
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D005472:Fluorouracil / Q000627:therapeutic use; D006498:Hepatectomy; D006801:Humans; D002955:Leucovorin / Q000627:therapeutic use; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D008297:Male; D009944:Organoplatinum Compounds / Q000627:therapeutic use; D012004:Rectal Neoplasms / Q000188:drug therapy* / Q000601:surgery
D009944:Organoplatinum Compounds; D002955:Leucovorin; D005472:Fluorouracil