title: Anti-inflammatory and immunomodulatory effects of Baccharis trimera aqueous extract on induced pleurisy in rats and lymphoproliferation in vitro.
abstract: Baccharis trimera is a widespread South American plant known as "carqueja". Medicinal teas prepared from the aerial parts of this plant are used in folk medicine in cases of liver diseases and inflammatory processes. We evaluated the effects of aqueous extract of B. trimera in the experimental inflammatory model of carrageenan-induced pleurisy in rat. The injection of carrageenan into the pleural cavity induces an influx of cells and fluid accumulation with a large number of polymorphonuclear leukocytes and increase of protein levels. The inflammation parameters were attenuated when B. trimera (400 and 800 mg/kg, i.p.) was administrated 30 min before the carrageenan. The immunomodulatory effects were evaluated in vitro on human peripheral blood mononuclear cells. The extract in concentration of 25, 50 and 100 mg/mL presented inhibited the T-lymphocytes proliferation stimulated by phytohemagglutinin, but these extract concentrations also presented cytotoxic effect. These results showed that the aqueous extract of B. trimera has anti-inflammatory effect.
authors.affiliation: Laboratório de Pesquisa em Biofísica Celular e Inflamação, Faculdade de Biociências, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brasil.
authors.forename: Elisiane Lozza
authors.initials: EL
authors.lastname: Paul
authors.forename: Adroaldo
authors.initials: A
authors.lastname: Lunardelli
authors.forename: Eduardo
authors.initials: E
authors.lastname: Caberlon
authors.forename: Cristiane Bernardes
authors.initials: CB
authors.lastname: de Oliveira
authors.forename: Roberto Christ Vianna
authors.initials: RC
authors.lastname: Santos
authors.forename: Vanderlei
authors.initials: V
authors.lastname: Biolchi
authors.forename: Carolina Maria Alves
authors.initials: CM
authors.lastname: Bastos
authors.forename: Karla Barbosa
authors.initials: KB
authors.lastname: Moreira
authors.forename: Fernanda Bordignon
authors.initials: FB
authors.lastname: Nunes
authors.forename: Grace
authors.initials: G
authors.lastname: Gosmann
authors.forename: Jarbas Rodrigues
authors.initials: JR
authors.lastname: de Oliveira
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D031175:Baccharis / Q000276:immunology; D002351:Carrageenan / Q000633:toxicity; D049109:Cell Proliferation / Q000187:drug effects; D005260:Female; D006801:Humans; D007155:Immunologic Factors / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D008213:Lymphocyte Activation / Q000276:immunology*; D008517:Phytotherapy / Q000379:methods; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000302:isolation & purification / Q000627:therapeutic use*; D010998:Pleurisy / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D014867:Water
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007155:Immunologic Factors; D010936:Plant Extracts; D014867:Water; D002351:Carrageenan