Fat on the move: intracellular motion of lipid droplets.
Lipid droplets are intracellular organelles that play central roles in lipid metabolism. In many cells, lipid droplets undergo active motion, typically along microtubules. This motion has been proposed to aid growth and breakdown of droplets, to allow net transfer of nutrients from sites of synthesis to sites of need and to deliver proteins and lipophilic signals. This review summarizes the current understanding of where, why and how lipid droplets move.
Welte
Michael A
MA
Department of Biology, University of Rochester, Rochester, NY 14627, USA. michael.welte@rochester.edu
D000818:Animals; D001692:Biological Transport / Q000502:physiology; D002352:Carrier Proteins; D002460:Cell Line; D004268:DNA-Binding Proteins / Q000378:metabolism; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism; D050356:Lipid Metabolism; D008565:Membrane Proteins / Q000378:metabolism; D020409:Molecular Motor Proteins / Q000378:metabolism; D015388:Organelles / Q000378:metabolism*; D000070778:Perilipin-1; D000070780:Perilipin-2; D000070796:Perilipin-3; D010750:Phosphoproteins / Q000378:metabolism; D011257:Pregnancy Proteins / Q000378:metabolism; D033921:Vesicular Transport Proteins
D002352:Carrier Proteins; D004268:DNA-Binding Proteins; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D020409:Molecular Motor Proteins; C038196:PLIN3 protein, human; D000070778:Perilipin-1; D000070780:Perilipin-2; D000070796:Perilipin-3; D010750:Phosphoproteins; D011257:Pregnancy Proteins; D033921:Vesicular Transport Proteins