[Effect of ichphans on the structural properties of erythrocyte membranes].
Morphological transformation of erythrocytes and structural changes in the erythrocyte membrane have been revealed by scanning electron microscopy and spin-probe technique. These effects were caused by the incorporation of ichphans, new generation drugs combining antioxidant and anticholinesterase effects, into the erythrocyte membrane and their distribution in the intramembrane space. Different distribution and modulatory effect of the derivatives with different hydrophobic properties have been shown. The derivatives with 8 and 10 carbon atoms in the aliphatic substituent were the most efficient modifiers of the membrane structure and morphology of erythrocytes.
Parshina
E Iu
EIu
Gendel'
L Ia
LIa
Rubin
A B
AB
D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D002462:Cell Membrane / Q000187:drug effects* / Q000648:ultrastructure*; D002478:Cells, Cultured; D004912:Erythrocytes / Q000187:drug effects* / Q000648:ultrastructure; D008051:Lipid Bilayers / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry / Q000494:pharmacology*; D000644:Quaternary Ammonium Compounds / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D013329:Structure-Activity Relationship
D000975:Antioxidants; D008051:Lipid Bilayers; D010636:Phenols; D000644:Quaternary Ammonium Compounds