title: Low dose vincristine-induced severe polyneuropathy in a Hodgkin lymphoma patient: a case report (vincristine-induced severe polyneuropathy).
abstract: Chemotherapeutic drugs are the most common toxic agents for peripheral nerves. Vincristine is a vinca alkaloid drug that is used for the treatment of several malignancies in combination with other chemotherapeutic agents. Treatment with intravenous (IV) vincristine at doses above 5 mg leads to a dose-dependent neuropathy with sensory symptoms but higher cumulative doses at around 30 to 50 mg are needed for the development of motor symptoms. The standard maximum adult IV vincristine dose is 2 mg IV per dose given at weekly intervals. However, administration of a single 2-mg dose IV vincristine may rarely result in the development of peripheral neuropathy. Few case reports have been presented on vincristine-associated severe paralysis in patients with preexisting hereditary neuropathy like Charcot-Marie Tooth (CMT) disease, who received doses even lower than 2 mg. Herein, we reported a Hodgkin lymphoma patient who developed severe polyneuropathy after receiving 2 mg vincristine treatment and was subsequently found to carry the CMT1A duplication responsible for CMT disease.
authors.affiliation: Department of Medical Oncology, Internal Medicine, Dicle University, Diyarbakir, Turkey. drtimcil@dicle.edu.tr
authors.forename: Timucin
authors.initials: T
authors.lastname: Cil
authors.forename: Abdullah
authors.initials: A
authors.lastname: Altintas
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Tamam
authors.forename: Esra
authors.initials: E
authors.lastname: Battaloğlu
authors.forename: Abdurrahman
authors.initials: A
authors.lastname: Isikdogan
mesh_terms: D000293:Adolescent; D000972:Antineoplastic Agents, Phytogenic; D002607:Charcot-Marie-Tooth Disease / Q000150:complications / Q000175:diagnosis / Q000235:genetics; D005260:Female; D006689:Hodgkin Disease / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D011115:Polyneuropathies / Q000139:chemically induced*; D011506:Proteins / Q000235:genetics; D014750:Vincristine / Q000009:adverse effects*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; C109561:CDRT1 protein, human; D011506:Proteins; D014750:Vincristine