title: The role of FloSeal in reducing epidural fibrosis in a rat laminectomy model.
abstract: OBJECTIVE
  An increased amount of fibrosis formed after lumbar surgery may be the underlying cause of the failed back surgery syndrome in most cases. Various materials have been used to prevent epidural fibrosis, but only limited success has been achieved. In this study, the authors investigated the effect of FloSeal (a gelatine-containing thrombin-based haemostatic agent) on spinal epidural fibrosis in a rat laminectomy model.
  
  
  METHODS
  Sixteen Wistar rats underwent laminectomy at L4 and L5 levels. In 8 rats, 0.5 mL of FloSeal was locally applied to the laminectomy site. The laminectomy site was irrigated with saline in the control group of 8 other rats. The rats were sacrificed four weeks later. Each specimen was examined for density of fibrosis, and both fibroblast and inflammatory cell density.
  
  
  RESULTS
  Epidural fibrosis density differed significantly between the FloSeal group and the control group. Evaluation of the fibroblast density and the inflammatory cell density showed a statistically significant difference between the FloSeal group and the control group.
  
  
  CONCLUSIONS
  Application of FloSeal at a laminectomy site may be useful to decrease adhesion at the interface between the dura mater and epidural fibrosis.
authors.affiliation: Department of Neurosurgery, Gazi University School of Medicine, Ankara, Turkey, GSM. fikretdogulu@hotmail.com
authors.forename: Fikret
authors.initials: F
authors.lastname: Dogulu
authors.forename: Emre
authors.initials: E
authors.lastname: Durdag
authors.forename: Berker
authors.initials: B
authors.lastname: Cemil
authors.forename: Gohkan
authors.initials: G
authors.lastname: Kurt
authors.forename: Gonca
authors.initials: G
authors.lastname: Ozgun
mesh_terms: D000818:Animals; D004824:Epidural Space / Q000473:pathology*; D005355:Fibrosis / Q000517:prevention & control; D005781:Gelatin Sponge, Absorbable / Q000494:pharmacology*; D007796:Laminectomy / Q000379:methods*; D008159:Lumbar Vertebrae / Q000601:surgery*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: C411004:FloSeal Matrix