Urate oxidase (rasburicase) for treatment of severe acute gout: a case report.
A 73-year-old female patient was referred to our department because of gouty arthritis in the right first toe. The patient suffered from progressive renal failure because of pauci-immune necrotising glomerulonephritis. As severe hyperuricaemia would further worsen progredient renal insufficiency and therapy with allopurinol was contraindicated because of renal insufficiency and previous pancytopenia, the patient was treated twice with intravenous rasburicase. This therapy was well tolerated by the patient and led to the decrease of serum uric acid below the detection limit within 24 hours.
Wipfler-Freibmuth
E
E
Department of Internal Medicine, General Hospital of the Elisabethinen, Klagenfurt, Austria.
Dejaco
C
C
Duftner
C
C
Gaugg
M
M
Kriessmayr-Lungkofler
M
M
Schirmer
M
M
D000208:Acute Disease; D000368:Aged; D000493:Allopurinol; D000075202:Contraindications; D005260:Female; D005921:Glomerulonephritis / Q000150:complications / Q000276:immunology; D006073:Gout / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D006074:Gout Suppressants / Q000627:therapeutic use*; D006801:Humans; D033461:Hyperuricemia / Q000097:blood / Q000150:complications / Q000188:drug therapy; D009336:Necrosis; D051437:Renal Insufficiency / Q000209:etiology; D016896:Treatment Outcome; D014503:Urate Oxidase / Q000627:therapeutic use*; D014527:Uric Acid / Q000097:blood
D006074:Gout Suppressants; C469709:rasburicase; D014527:Uric Acid; D000493:Allopurinol; D014503:Urate Oxidase