No association of dysbindin with symptom factors of schizophrenia in an Irish case-control sample.
Robust associations between the dysbindin gene (DTNBP1) and schizophrenia have been demonstrated in many but not all samples, and evidence that this gene particularly predisposes to negative symptoms in this illness has been presented. The current study sought to replicate the previously reported negative symptom associations in an Irish case-control sample. Association between dysbindin and schizophrenia has been established in this cohort, and a factor analysis of the assessed symptoms yielded three factors, Positive, Negative, and Schneiderian. The sequential addition method was applied using UNPHASED to assess the relationship between these symptom factors and the high-risk haplotype. No associations were detected for any of the symptom factors indicating that the dysbindin risk haplotype does not predispose to a particular group of symptoms in this sample. Several possibilities, such as differing risk haplotypes, may explain this finding.
Bergen
Sarah E
SE
Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia.|Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia.
Fanous
Ayman H
AH
Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia.|Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia.|Washington VA Medical Center, Washington, District of Columbia.|Department of Psychiatry, Georgetown University Medical Center, Washington, District of Columbia.
Kuo
Po-Hsiu
PH
Department of Public Health, National Taiwan University, Taipei, Taiwan.
Wormley
Brandon K
BK
Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia.|Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia.
O'Neill
F Anthony
FA
Department of Mental Health, Queen's University, Belfast, Ireland.
Walsh
Dermot
D
Health Research Board, Dublin, Ireland.
Riley
Brien P
BP
Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia.|Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia.|Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia.
Kendler
Kenneth S
KS
Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia.|Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia.|Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia.
D000483:Alleles; D002352:Carrier Proteins / Q000235:genetics*; D016022:Case-Control Studies; D000074765:Dysbindin; D049029:Dystrophin-Associated Proteins; D005192:Family Health; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D007494:Ireland; D008957:Models, Genetic; D020641:Polymorphism, Single Nucleotide; D012044:Regression Analysis; D012306:Risk; D012559:Schizophrenia / Q000235:genetics*
D002352:Carrier Proteins; C432416:DTNBP1 protein, human; D000074765:Dysbindin; D049029:Dystrophin-Associated Proteins