Polyurethane and PTFE membranes for guided bone regeneration: histopathological and ultrastructural evaluation.
OBJECTIVE
The purpose of this study was to research a membrane material for use in guided bone regeneration.


METHODS
In this study, 25 male Wistar rats were used to analyze the biocompatibility and degradation process of biomembranes. The morphological changes in subcutaneous implantations were assessed after 7, 14, 21, 28 and 70 days. The materials were made of polyurethane polymer (AUG) obtained from vegetal oil (Ricinus communis) and polytetrafluoroethylene membrane (PTFE). The surface characteristics of the physical barriers in scanning electronic microscopic (SEM) were also evaluated.


RESULTS
In both groups, the initial histological analysis showed moderate inflammatory infiltrate, which was predominantly polymorphonuclear. There was also a presence of edema, which was gradually replaced by granulation tissue, culminating in a fibrous capsule. In the AUG group, some multinucleated giant cells were present in the contact interface, with the space previously occupied by the material. However, membrane degradation was not observed during the period studied. According to the present SEM findings, porosity was not detected in the AUG or PTFE membranes.


CONCLUSIONS
The researched material is biocompatible and the degradation process is extremely slow or may not even occur at all.
Monteiro
Adriana-Socorro-Ferreira
AS
Department of Diagnosis and Surgery, São José dos Campos Dental School, UNESP Avenida Engenheiro Francisco José Longo, 777, Caixa Postal 314, CEP 12245-000, São José dos Campos, SP - Brazil. dri.monteiro@fosjc.unesp.br
Macedo
Luís-Guilherme-Scavone
LG
Macedo
Nelson-Luiz
NL
Balducci
Ivan
I
D000818:Animals; D001861:Bone Regeneration; D001842:Bone and Bones / Q000473:pathology / Q000648:ultrastructure; D048091:Guided Tissue Regeneration / Q000379:methods*; D008297:Male; D008567:Membranes, Artificial; D011138:Polytetrafluoroethylene; D011140:Polyurethanes; D051381:Rats; D017208:Rats, Wistar
D008567:Membranes, Artificial; D011140:Polyurethanes; D011138:Polytetrafluoroethylene