4-1BB as a therapeutic target for human disease.
4-1BB (CD137) is being thought of as an attractive target for immunotherapy of many human immune diseases based on encouraging results with 4-1BB agonistic antibody treatment in mouse models of cancer, autoimmune disease, asthma and additionally as a means to improve vaccination. In this review, we will summarize the results of basic research on 4-1BB and 4-1BB immunotherapy of disease and provide some potential mechanistic insights into the many stimulatory and regulatory functions of 4-1BB.
Lee
Seung-Woo
SW
Molecular Immunology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, California, 92037, USA.
Croft
Michael
M
D000818:Animals; D001327:Autoimmune Diseases / Q000628:therapy*; D006801:Humans; D051379:Mice; D009369:Neoplasms / Q000628:therapy*; D053261:Tumor Necrosis Factor Receptor Superfamily, Member 9 / Q000037:antagonists & inhibitors* / Q000378:metabolism
D053261:Tumor Necrosis Factor Receptor Superfamily, Member 9