Investigating epigenetic influences on seizure disposition.
Rats selectively bred to be seizure-prone versus resistant naturally exhibit behaviors, neuroanatomy and physiology that are reminiscent of attention deficit hyperactivity disorder (ADHD) and autism spectrum disorders (ASD) in humans. Evidence suggests these characteristics evolve via genetic/epigenetic mechanisms acting prior to birth that most likely involve aberrant lipid handling.
Gilby
Krista L
KL
Department of Psychology, Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada.
D000818:Animals; D001289:Attention Deficit Disorder with Hyperactivity / Q000235:genetics / Q000503:physiopathology; D001321:Autistic Disorder / Q000235:genetics / Q000503:physiopathology; D001522:Behavior, Animal; D004195:Disease Models, Animal; D006801:Humans; D051381:Rats; D012640:Seizures / Q000209:etiology* / Q000235:genetics*