Vitamin D deficiency in the intensive care unit: an invisible accomplice to morbidity and mortality?
The association between vitamin D deficiency and chronic illness is well-known. Vitamin D deficiency has been associated with increased mortality in the general population. Despite this knowledge, vitamin D insufficiency is seldom considered and rarely replaced adequately, if at all, in critically ill patients in intensive care. We present a hypothetic model demonstrating how vitamin D deficiency may be an unrecognized contributor to adverse outcome in intensive care patients.
Lee
Paul
P
Department of Endocrinology, St Vincent's Hospital, Sydney, NSW 2010, Australia. p.lee@garvan.org.au
Nair
Priya
P
Eisman
John A
JA
Center
Jacqueline R
JR
D000284:Administration, Oral; D002118:Calcium / Q000627:therapeutic use; D002318:Cardiovascular Diseases / Q000453:epidemiology; D002908:Chronic Disease; D006801:Humans; D006996:Hypocalcemia / Q000188:drug therapy / Q000453:epidemiology; D007362:Intensive Care Units / Q000706:statistics & numerical data*; D008274:Magnesium / Q000097:blood; D052016:Mucositis / Q000453:epidemiology; D009102:Multiple Organ Failure / Q000453:epidemiology; D009752:Nutritional Status; D010281:Parathyroid Hormone / Q000502:physiology; D015996:Survival Rate; D014808:Vitamin D Deficiency / Q000453:epidemiology* / Q000401:mortality / Q000503:physiopathology*
D010281:Parathyroid Hormone; D008274:Magnesium; D002118:Calcium