title: The use of mushroom-forming fungi for the production of N-glycosylated therapeutic proteins.
abstract: The market for N-glycosylated therapeutic proteins represents multi-billion dollars in sales and is growing more than 10% each year. This requires cost-effective production platforms that display correct and homogeneous N-glycosylation. Based on recent results, we propose to use mushroom-forming basidiomycetes for the production of N-glycosylated therapeutic proteins.
authors.affiliation: Molecular Microbiology and Kluyver Center for Genomics of Industrial Fermentations, Institute of Biomembranes, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands.
authors.forename: Elsa
authors.initials: E
authors.lastname: Berends
authors.forename: Karin
authors.initials: K
authors.lastname: Scholtmeijer
authors.forename: Han A B
authors.initials: HA
authors.lastname: Wösten
authors.forename: Dirk
authors.initials: D
authors.lastname: Bosch
authors.forename: Luis G
authors.initials: LG
authors.lastname: Lugones
mesh_terms: D000363:Agaricales / Q000235:genetics / Q000378:metabolism*; D001688:Biological Products / Q000096:biosynthesis* / Q000235:genetics; D001709:Biotechnology / Q000379:methods; D006031:Glycosylation; D008954:Models, Biological; D030781:Organisms, Genetically Modified / Q000235:genetics / Q000378:metabolism*; D011994:Recombinant Proteins / Q000096:biosynthesis* / Q000235:genetics; D013678:Technology, Pharmaceutical / Q000379:methods
chemical_list: D001688:Biological Products; D011994:Recombinant Proteins