title: Nucleoside modification with boron clusters and their metal complexes.
abstract: General methods for the synthesis of nucleosides modified with borane clusters and metallacarborane complexes are presented. These include: (1) the click chemistry approach based on Huisgen 1,3-dipolar cycloaddition and (2) tethering of the metallacarborane group to the aglycone of a nucleoside via a dioxane ring opening in oxonium metallacarborane derivatives. The proposed methodologies broaden the availability of nucleoside-borane cluster conjugates and open up new areas for their applications.
authors.affiliation: Institute for Medical Biology, Polish Academy of Sciences, Laboratory of Molecular Virology and Biological Chemistry, Lodz, Poland.
authors.forename: Blazej A
authors.initials: BA
authors.lastname: Wojtczak
authors.forename: Agnieszka B
authors.initials: AB
authors.lastname: Olejniczak
authors.forename: Zbigniew J
authors.initials: ZJ
authors.lastname: Lesnikowski
mesh_terms: D001896:Boron Compounds / Q000737:chemistry* / Q000378:metabolism; D002621:Chemistry / Q000379:methods*; D009705:Nucleosides / Q000138:chemical synthesis*
chemical_list: D001896:Boron Compounds; D009705:Nucleosides