title: Alternative I-D exchange reaction on pyrimidine and purine nuclei mediated by tributyltin hydride using THF-d8 as a deuterium source.
abstract: A novel method for the regioselective deuteration of pyrimidine and purine rings mediated by Bu(3)SnH using THF-d(8) as a deuterium source on the basis of a radical reaction was developed.
authors.affiliation: Chemical Technology Laboratory, Taiho Pharmaceutical Co, Ltd, Kodama-gun, Saitama 367-0241, Japan. t-mutsumi@taiho.co.jp
authors.forename: Tomonobu
authors.initials: T
authors.lastname: Mutsumi
authors.forename: Kazuo
authors.initials: K
authors.lastname: Maruhashi
authors.forename: Yasunari
authors.initials: Y
authors.lastname: Monguchi
authors.forename: Hironao
authors.initials: H
authors.lastname: Sajiki
mesh_terms: D041961:Deuterium Exchange Measurement; D011687:Purines / Q000737:chemistry*; D011743:Pyrimidines / Q000737:chemistry*; D014220:Trialkyltin Compounds / Q000737:chemistry*
chemical_list: D011687:Purines; D011743:Pyrimidines; D014220:Trialkyltin Compounds; C011559:tributyltin; C030986:pyrimidine; C030985:purine