title: Human cellular restriction factors that target HIV-1 replication.
abstract: Recent findings have highlighted roles played by innate cellular factors in restricting intracellular viral replication. In this review, we discuss in brief the activities of apolipoprotein B mRNA-editing enzyme 3G (APOBEC3G), bone marrow stromal cell antigen 2 (BST-2), cyclophilin A, tripartite motif protein 5 alpha (Trim5alpha), and cellular microRNAs as examples of host restriction factors that target HIV-1. We point to countermeasures encoded by HIV-1 for moderating the potency of these cellular restriction functions.
authors.affiliation: Laboratory of Molecular Microbiology, NIAID, the National Institutes of Health, Bethesda, Maryland, USA.
authors.forename: Klaus
authors.initials: K
authors.lastname: Strebel
authors.forename: Jeremy
authors.initials: J
authors.lastname: Luban
authors.forename: Kuan-Teh
authors.initials: KT
authors.lastname: Jeang
mesh_terms: D000071480:APOBEC-3G Deaminase; D015703:Antigens, CD / Q000502:physiology; D000090103:Antiviral Restriction Factors; D002352:Carrier Proteins / Q000502:physiology; D021984:Cyclophilin A / Q000502:physiology; D003564:Cytidine Deaminase / Q000502:physiology; D058851:GPI-Linked Proteins; D015658:HIV Infections / Q000276:immunology* / Q000821:virology; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D008562:Membrane Glycoproteins / Q000502:physiology; D035683:MicroRNAs / Q000502:physiology; D000070584:Tripartite Motif Proteins; D044767:Ubiquitin-Protein Ligases; D014779:Virus Replication / Q000276:immunology*; D000074010:Bone Marrow Stromal Antigen 2
chemical_list: D000071480:APOBEC-3G Deaminase; D015703:Antigens, CD; D000090103:Antiviral Restriction Factors; D002352:Carrier Proteins; D021984:Cyclophilin A; D003564:Cytidine Deaminase; D058851:GPI-Linked Proteins; D008562:Membrane Glycoproteins; D035683:MicroRNAs; D000070584:Tripartite Motif Proteins; D044767:Ubiquitin-Protein Ligases; C094572:BST2 protein, human; D000074010:Bone Marrow Stromal Antigen 2; C477346:TRIM5 protein, human; C464924:APOBEC3G protein, human