title: Challenges in investigating transient rash illness in nursery children.
abstract: BACKGROUND
  In October 2007, the Thames Valley Health Protection Unit (TVHPU) was notified by a parent that her child developed a transient rash after eating lunch at a nursery in Oxfordshire. An initial investigation undertaken by TVHPU was escalated when similar incidents were reported in nurseries in other parts of England.
  
  
  METHODS
  A detailed epidemiological and food tracing investigation was conducted to ascertain the aetiology.
  
  
  RESULTS
  Investigations revealed 11 incidents affecting 164 children between July and November 2007 in six nurseries operated by two companies. The symptoms included a transient rash around the mouth and hands of children who ate meals prepared on site by the nurseries. Consumption of the lunch main course appeared to be a strong aetiological factor. Expert opinion pointed to biogenic amines (e.g. histamine) as a possible cause for the symptoms displayed, but there was insufficient evidence to support testing of food samples.
  
  
  CONCLUSIONS
  The incident highlighted significant gaps in reporting of unexplained symptoms among children in nurseries, indicating that such incidents do not always come to the attention of public health authorities. Timely notification to HPUs will enable prompt investigation, increase the likelihood of identifying the cause and inform appropriate responses to prevent future incidents.
authors.affiliation: Thames Valley Health Protection Unit, John Eccles House, Robert Robinson Avenue, Oxford Science Park, Oxford, UK. karthikeyan_doc@yahoo.co.uk
authors.forename: K
authors.initials: K
authors.lastname: Paranthaman
authors.forename: S
authors.initials: S
authors.lastname: Pooransingh
authors.forename: N
authors.initials: N
authors.lastname: McCarthy
authors.forename: P
authors.initials: P
authors.lastname: Saunders
authors.forename: E
authors.initials: E
authors.lastname: Haworth
mesh_terms: D002675:Child, Preschool; D004196:Disease Outbreaks; D004739:England / Q000453:epidemiology; D005076:Exanthema / Q000453:epidemiology* / Q000209:etiology; D005148:Facial Dermatoses / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D005506:Food Contamination; D006229:Hand Dermatoses / Q000453:epidemiology* / Q000209:etiology; D006801:Humans; D007223:Infant; D008297:Male; D012578:Schools, Nursery