title: Homophymines B-E and A1-E1, a family of bioactive cyclodepsipeptides from the sponge Homophymia sp.
abstract: Nine new cyclodepsipeptides, homophymines B-E (2-5) and A1-E1 (1a-5a), were isolated from the polar extracts of the sponge Homophymia sp. The new structures, featuring new polyketide-derived end groups, were determined by interpretation of NMR and MS data. The configurations of the new end groups was secured by the application of J-based configurational analysis. Homophymines displayed very potent antiproliferative activity (IC(50) in the nM range) against a panel of human cancer cell lines.
authors.affiliation: Dipartimento di Chimica delle Sostanze Naturali, Università di Napoli Federico II, via D. Montesano 49, 80131, Napoli, Italy.
authors.forename: Angela
authors.initials: A
authors.lastname: Zampella
authors.forename: Valentina
authors.initials: V
authors.lastname: Sepe
authors.forename: Filomena
authors.initials: F
authors.lastname: Bellotta
authors.forename: Paolo
authors.initials: P
authors.lastname: Luciano
authors.forename: Maria Valeria
authors.initials: MV
authors.lastname: D'Auria
authors.forename: Thierry
authors.initials: T
authors.lastname: Cresteil
authors.forename: Cécile
authors.initials: C
authors.lastname: Debitus
authors.forename: Sylvain
authors.initials: S
authors.lastname: Petek
authors.forename: Christiane
authors.initials: C
authors.lastname: Poupat
authors.forename: Alain
authors.initials: A
authors.lastname: Ahond
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D047630:Depsipeptides / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D011161:Porifera / Q000737:chemistry*
chemical_list: D047630:Depsipeptides