Primary ovarian leiomyosarcoma associated with Brenner tumor.
BACKGROUND
Primary ovarian leiomyosarcoma (POL) is rare. To the best of our knowledge, POL associated with a Brenner tumor has not been previously documented.


METHODS
A case of POL associated with a Brenner tumor is reported. Although the poorly differentiated component of the tumor was negative for SMA, the presence of spindle cells in the higher differentiated component with fascicle arrangement and immunoreactivity for SMA and strong staining of a poorly differentiated component for desmin and vimentin established the diagnosis.


CONCLUSIONS
This case indicates that since malignant tumor cells may lose some antigen markers, thorough sampling and immunohistochemistry are necessary. EMA-immunopositivity only could not preclude the diagnosis of leiomyosarcoma.
Li
Y
Y
Department of Pathology, Shanghai First Maternity and Infant Health Hospital, Tongji University, Shanghai, China.
Feng
L D
LD
Ma
A G
AG
Lu
H J
HJ
D000368:Aged; D001948:Brenner Tumor / Q000473:pathology*; D005260:Female; D006801:Humans; D007890:Leiomyosarcoma / Q000473:pathology*; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D010051:Ovarian Neoplasms / Q000473:pathology*