Hypersensitivity reactions to oxaliplatin.
Oxaliplatin is a third-generation platinum compound that is used as a single agent and in combination with fluorouracil (5-FU) to treat colorectal and gastric carcinoma. The patients treated with oxaliplatin may develop hypersensitivity and idiosyncratic reactions, although these complications are known to be rare. We report here on two patients who suffered with metastatic colorectal cancer and who underwent palliative combination chemotherapy with oxaliplatin; they then developed hypersensitivity reactions to oxaliplatin. The first case had an anaphylatic reaction immediately after the beginning of the 7(th) to 8(th) cycle infusion of oxaliplatin. The second case developed repeated febrile episodes from the 4(th) to 8(th) cycles of oxaliplatin infusion. With the increasing use of oxaliplatin in clinical practice, we are now encountering an increasing incidence of suspected hypersensitivity reactions. Physicians should keep their eyes wide open and carefully observe for the clinical manifestations of these hypersensitivity reactions.
Lee
Kyoung-Hwan
KH
Department of Internal Medicine, St. Vincent's Hospital, The Catholic University of Korea, Suwon, Korea.
Park
Yong Jai
YJ
Kim
Eun Sun
ES
Hwang
Hui Jeong
HJ
Shim
Byoung Yong
BY
Kim
Hoon-Kyo
HK