Chemical composition and antibacterial activity of the essential oil of Cordia verbenacea from the Venezuelan Andes.
The essential oil of Cordia verbenacea D.C. (Boraginaceae) that grows in Mérida-Venezuela was obtained by hydrodistillation from the aerial parts of the plant, yielding 0.21%. The oil was analyzed by GC-FID and GC-MS. Thirty one components which made up 94.3% of the oil were identified. The most abundant constituents found were: tricyclene (23.9%), bicyclogermacrene (11.7%), germacrene D (9.9%) and beta-caryophyllene (8.2%). Antibacterial activity determination was carried out according to the disc diffusion assay. Activity against Gram-positive bacteria Staphylococcus aureus ATCC 6538 and Enterococcus faecalis ATCC 29212, at a minimal inhibitory concentration (MIC) of 170 microg/mL and 200 microg/mL, was found.
Meccia
Gina
G
Research Institute, Faculty of Pharmacy and Bioanalysis, University of Los Andes, Mérida, Venezuela. gmeccia@ula.ve
Rojas
Luis B
LB
Velasco
Judith
J
Díaz
Tulia
T
Usubillaga
Alfredo
A
Arzola
Juan Carmona
JC
Ramos
Sulymar
S
D000531:Altitude; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002849:Chromatography, Gas / Q000379:methods; D031213:Cordia / Q000737:chemistry*; D017753:Ecosystem; D013293:Enterococcus faecalis / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D007711:Klebsiella pneumoniae / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D009822:Oils, Volatile / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D018514:Plant Structures / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects; D014687:Venezuela
D000900:Anti-Bacterial Agents; D009822:Oils, Volatile