title: Human angiostrongyliasis outbreak in Dali, China.
abstract: BACKGROUND
  Several angiostrongyliasis outbreaks have been reported in recent years but the disease continues to be neglected in public health circles. We describe an outbreak in Dali, southwest China in order to highlight some key problems for the control of this helminth infection.
  
  
  RESULTS
  All available medical records of suspected angiostrongyliasis patients visiting hospitals in Dali in the period 1 October 2007-31 March 2008 were reviewed, and tentative diagnoses of varying strengths were reached according to given sets of criteria. Snails collected from local markets, restaurants and natural habitats were also screened for the presence of Angiostrongylus cantonensis. A total of 33 patients met criteria for infection, and 11 among them were classified as clinically confirmed. An additional eight patients were identified through a surveillance system put in operation in response to the outbreak. The epidemic lasted for 8 months with its peak in February 2008. Of the 33 patients, 97.0% complained of severe headache. 84.8% patients had high eosinophil cell counts either in the peripheral blood or in cerebrospinal fluid (CSF). Three-quarters of the patients were treated with a combination of albendazole and corticosteroids, resulting in significantly improved overall conditions. Twenty-two patients reported the consumption of raw or undercooked snails prior to the onset of the symptoms, and approximately 1.0% of the Pomacea canaliculata snails on sale were found to be infected with A. cantonensis. The snails were also found in certain habitats around Dali but no parasites were detected in these populations.
  
  
  CONCLUSIONS
  The import and sale of infected P. canaliculata is the likely trigger for this angiostrongyliasis outbreak. Awareness of angiostrongyliasis must be raised, and standardized diagnosis and treatment are needed in order to provide clinicians with a guide to address this disease. Health education campaigns could limit the risk, and a hospital-based surveillance system should be established in order to detect future outbreaks.
authors.affiliation: National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, People's Republic of China.
authors.forename: Shan
authors.initials: S
authors.lastname: Lv
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.forename: Shao-Rong
authors.initials: SR
authors.lastname: Chen
authors.forename: Li-Bo
authors.initials: LB
authors.lastname: Wang
authors.forename: Wen
authors.initials: W
authors.lastname: Fang
authors.forename: Feng
authors.initials: F
authors.lastname: Chen
authors.forename: Jin-Yong
authors.initials: JY
authors.lastname: Jiang
authors.forename: Yuan-Lin
authors.initials: YL
authors.lastname: Li
authors.forename: Zun-Wei
authors.initials: ZW
authors.lastname: Du
authors.forename: Xiao-Nong
authors.initials: XN
authors.lastname: Zhou