title: Partial potentials of selected cardiac muscle regions and heart activity model based on single fibres.
abstract: We present single fibre heart activity model (SFHAM) based on the current flow through the five bunches of fibres of the cardiac muscle (CM). The five effective fibres are identified and assigned to the appropriate segments of CM. Analytical functions describing ionic flows along the fibres are derived and proposed. The parameters determining the shapes and amplitudes of the functions proposed are obtained on the basis of standard 12-lead ECG measurements after numerical fitting procedures concentrating on the QRS-waves. As a consequence, five independent courses of partial, transient potentials are obtained representing: anterior, inferior, lateral, posterior walls, and interventricular septum activities, respectively. Moreover, to check our theoretical results we compare the potentials calculated with those from physical measurements performed on the patient's body surface. We expect that SFHAM will permit detection of pathological changes in particular fragments of CM.
authors.affiliation: Institute for Physico-Medical Research, Puszczykowo, Poland. prezes@ibf.com.pl
authors.forename: J S
authors.initials: JS
authors.lastname: Janicki
authors.forename: W
authors.initials: W
authors.lastname: Leoński
authors.forename: J
authors.initials: J
authors.lastname: Jagielski
mesh_terms: D000200:Action Potentials; D018780:Body Surface Potential Mapping; D004562:Electrocardiography / Q000379:methods*; D004594:Electrophysiology / Q000379:methods; D006321:Heart / Q000502:physiology*; D006329:Heart Conduction System; D006352:Heart Ventricles; D006801:Humans; D007477:Ions; D008953:Models, Anatomic; D008962:Models, Theoretical; D009200:Myocardial Contraction; D009206:Myocardium / Q000378:metabolism*; D012815:Signal Processing, Computer-Assisted
chemical_list: D007477:Ions