Influence of splitting on dissolution properties of metoprolol tablets.
The objective of this work was to compare several profiles of dissolution data for metoprolol controlled release tablet formulations in order to identify possible changes in dissolution profiles of whole and scored tablets. Adequate design of score lines (on one or both sides) as well as the technology of preparation of tablet mixtures ensure forming a score line of adequate thickness, shape, size, curvature. According to the obtained results, this type of extended release formulation is eligible for splitting and use in therapy either as a whole or scored tablets.
Vranić
Edina
E
Department of Pharmaceutical Technology, University of Sarajevo, Bosnia and Herzegovina.
Uzunović
Alija
A
D000319:Adrenergic beta-Antagonists / Q000737:chemistry* / Q000493:pharmacokinetics*; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D008790:Metoprolol / Q000737:chemistry* / Q000493:pharmacokinetics*; D008956:Models, Chemical; D012995:Solubility; D013607:Tablets
D000319:Adrenergic beta-Antagonists; D003692:Delayed-Action Preparations; D013607:Tablets; D008790:Metoprolol