title: Cardiometabolic risk factors in experimental spinal cord injury.
abstract: Cardiometabolic risk factors are sorely underreported after spinal cord injury (SCI), despite the high prevalence of metabolic disorders and cardiovascular mortality in this population. Body-composition analysis and serum-lipid profiling are two assessments that are beginning to be more widely used to document metabolic changes after clinical SCI. Individuals with SCI have been reported to carry increased visceral fat and to exhibit altered serum-lipid levels. However, little is known about the development of these cardiometabolic risk factors in animal models. Using a combination of magnetic resonance imaging (MRI) and adipose tissue dissection, we show that visceral and subcutaneous adipose tissue were both increased at 1 month, but not at 1 week, after complete T3 SCI in rats. Additionally, at 1 month post injury, T3 SCI rats exhibited nonfasting serum hypertriglyceridemia, a result obtained using both standard clinical methods and a home cholesterol monitoring device (CardioChek). Interestingly, at 1 month post injury, rats with complete T10 SCI did not show an increase in either visceral adiposity or serum triglyceride levels. The fact that complete high-thoracic SCI disrupts lipid metabolism and perturbs fat storage in the subacute period, while low-thoracic SCI does not, suggests that differences in descending sympathetic control of adipose tissue might play a role in these changes. These results provide the first evidence of cardiometabolic risk factors in experimental animals with SCI, and are a starting point for investigations of the etiology of obesity and metabolic dysfunctions that often accompany SCI.
authors.affiliation: International Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: Jessica
authors.initials: J
authors.lastname: Inskip
authors.forename: Ward
authors.initials: W
authors.lastname: Plunet
authors.forename: Leanne
authors.initials: L
authors.lastname: Ramer
authors.forename: John Byron
authors.initials: JB
authors.lastname: Ramsey
authors.forename: Andrew
authors.initials: A
authors.lastname: Yung
authors.forename: Piotr
authors.initials: P
authors.lastname: Kozlowski
authors.forename: Matt
authors.initials: M
authors.lastname: Ramer
authors.forename: Andrei
authors.initials: A
authors.lastname: Krassioukov
mesh_terms: D000818:Animals; D001342:Autonomic Nervous System Diseases / Q000150:complications / Q000503:physiopathology; D002318:Cardiovascular Diseases / Q000209:etiology* / Q000378:metabolism* / Q000503:physiopathology; D004195:Disease Models, Animal; D004210:Dissection; D006949:Hyperlipidemias / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology; D050152:Intra-Abdominal Fat / Q000294:innervation / Q000378:metabolism / Q000503:physiopathology; D050356:Lipid Metabolism / Q000502:physiology; D052439:Lipid Metabolism Disorders / Q000209:etiology* / Q000378:metabolism* / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012307:Risk Factors; D013119:Spinal Cord Injuries / Q000150:complications* / Q000378:metabolism* / Q000503:physiopathology; D014280:Triglycerides / Q000097:blood
chemical_list: D014280:Triglycerides