Acrylamide formed at physiological temperature as a result of asparagine oxidation.
Acrylamide is a probable human carcinogen that is neurotoxic to both humans and animals. It is known to be formed during cooking of foods at temperatures higher than 120 degrees C. The present study demonstrates that acrylamide can also be formed at physiological conditions (37 degrees C, pH 7.4) when asparagine is incubated in the presence of hydrogen peroxide (H(2)O(2)). The formation of acrylamide under these conditions is dependent on the incubation time and the concentration of H(2)O(2). Thus, the results raise the question of the possible endogenous formation of acrylamide in pathological conditions that are associated with long-term oxidative stress. Further studies are therefore warranted to clarify the possible endogenous formation of acrylamide and its significance in chronic conditions that are known to be associated with oxidative stress.
Tareke
Eden
E
Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079, USA. edunatar@hotmail.com
Heinze
Thomas M
TM
Gamboa da Costa
Gonçalo
G
Ali
Syed
S
D020106:Acrylamide / Q000737:chemistry*; D001216:Asparagine / Q000737:chemistry*; D006861:Hydrogen Peroxide / Q000737:chemistry; D010084:Oxidation-Reduction; D013696:Temperature
D020106:Acrylamide; D001216:Asparagine; D006861:Hydrogen Peroxide