Inter- and intramolecular addition reactions of electron-deficient alkenes with alkyl radicals, generated by SET-photochemical decarboxylation of carboxylic acids, serve as a mild and efficient method for the preparation of gamma-amino acids and macrocyclic lactones.
Inter- and intramolecular additions of alkyl radicals, generated by SET photochemical decarboxylation reactions of free carboxylic acids, to electron-deficient alkenes take place under mild conditions as part of efficient routes for the formation of N-Boc gamma-amino acids and macrocyclic lactones.
Yoshimi
Yasuharu
Y
Department of Applied Chemistry and Biotechnology, Graduate School of Engineering, University of Fukui, 3-9-1 Bunkyo, Fukui 910-8507, Japan. yyoshimi@u-fukui.ac.jp
Masuda
Miho
M
Mizunashi
Tomoyuki
T
Nishikawa
Keisuke
K
Maeda
Kousuke
K
Koshida
Nobumasa
N
Itou
Tatsuya
T
Morita
Toshio
T
Hatanaka
Minoru
M
D000473:Alkanes / Q000737:chemistry*; D000475:Alkenes / Q000737:chemistry*; D000596:Amino Acids / Q000737:chemistry*; D002264:Carboxylic Acids / Q000737:chemistry*; D004579:Electron Transport; D004583:Electrons; D007783:Lactones / Q000737:chemistry*; D047028:Macrocyclic Compounds / Q000737:chemistry; D055668:Photochemical Processes
D000473:Alkanes; D000475:Alkenes; D000596:Amino Acids; D002264:Carboxylic Acids; D007783:Lactones; D047028:Macrocyclic Compounds