The effect of physical exercise on endothelial function.
Endothelium is essential for maintenance of health of the vessel wall and for the local regulation of vascular tone and structure and haemostasis. Regular physical exercise, which is known to promote a favourable cardiovascular state, may improve endothelial function via several mechanisms. Indeed, it augments blood flow and laminar shear stress, resulting in increased nitric oxide production and bioavailability. In this regard, the beneficial effects of training on endothelial function can be mediated in a number of ways, including synthesis of molecular mediators, changes in neurohormonal release and oxidant/antioxidant balance. On the other hand, physical exercise can also elicit systemic molecular pathways connected with angiogenesis and chronic anti-inflammatory action with consequent modification of the endothelial function. However, its benefit depends on the type and intensity of training performed. While strenuous exercise increases oxidative metabolism and produces a pro-oxidant environment, only regular moderate physical activity promotes an antioxidant state and preserves endothelial function. Thus, exercise may have a beneficial effect on the development of cardiovascular disease through preserving endothelial function.
Di Francescomarino
Samanta
S
Department of Clinical Science and Bioimaging, University of Chieti, Chieti, Italy.
Sciartilli
Adolfo
A
Di Valerio
Valentina
V
Di Baldassarre
Angela
A
Gallina
Sabina
S
D000375:Aging / Q000502:physiology; D002318:Cardiovascular Diseases / Q000503:physiopathology / Q000517:prevention & control*; D015815:Cell Adhesion Molecules / Q000378:metabolism; D015777:Eicosanoids / Q000378:metabolism; D019332:Endothelin-1 / Q000378:metabolism; D004730:Endothelium, Vascular / Q000166:cytology / Q000502:physiology*; D015444:Exercise / Q000502:physiology*; D006801:Humans; D032389:Myocytes, Smooth Muscle / Q000378:metabolism; D018919:Neovascularization, Physiologic / Q000502:physiology; D009569:Nitric Oxide / Q000378:metabolism; D010085:Oxidative Phosphorylation; D018384:Oxidative Stress; D033081:Shear Strength; D013312:Stress, Physiological; D010959:Tissue Plasminogen Activator / Q000378:metabolism; D014664:Vasodilation
D015815:Cell Adhesion Molecules; D015777:Eicosanoids; D019332:Endothelin-1; D009569:Nitric Oxide; D010959:Tissue Plasminogen Activator