Nomenclature of ISCRl elements capable of mobilizing antibiotic resistance genes present in complex class 1 integrons.
The dissemination of many antibiotic resistance genes has arisen among members of the family Enterobacteriaceae. The dissemination mechanism of these antibiotic resistance genes is closely linked with insertion sequence common region 1 (ISCRl). Thus, caution must be taken in clinical settings to prevent further dissemination of these antibiotic resistance genes. A nomenclature system of ISCRl variants, important for the antibiotic resistance dissemination, was proposed. The proposed system can designate all ISCRl variants on the basis of the detection time and by considering amino-acid substitution(s) compared with ISCRla. This nomenclature system of ISCRl variants can be applied to 19 groups (ISCRl to ISCR19) of the ISCR family and help some researchers to correctly designate new ISCR subgroups.
Sohn
Seung Ghyu
SG
Drug Resistance Proteomics Laboratory, Department of Biological Sciences, Myongji University, Gyeonggido 449-728, Republic of Korea.
Lee
Jae Jin
JJ
Song
Jae Seok
JS
Lee
Jung Hun
JH
Sun
Ha Ik
HI
Park
Kwang Seung
KS
Bae
Ii Kwon
IK
Lee
Jung-Hyun
JH
Jeong
Byeong Chul
BC
Lee
Sang Hee
SH
D024881:Drug Resistance, Bacterial; D004755:Enterobacteriaceae / Q000187:drug effects / Q000235:genetics*; D032023:Integrons; D008969:Molecular Sequence Data; D009626:Terminology as Topic