Water-soluble graphene covalently functionalized by biocompatible poly-L-lysine.
Graphene sheets functionalized covalently with biocompatible poly-l-lysine (PLL) were first synthesized in an alkaline solution. PLL-functionalized graphene is water-soluble and biocompatible, which makes it a novel material promising for biological applications. Graphene sheets played an important role as connectors to assemble these active amino groups of poly-l-lysine, which provided a very biocompatible environment for further functionalization, such as attaching bioactive molecules. As an example, an amplified biosensor toward H(2)O(2) based on linking peroxidase onto PLL-functionalized graphene was investigated.
Shan
Changsheng
C
State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, and Graduate University of the Chinese Academy of Sciences, Chinese Academy of Sciences, Changchun 130022, PR China.
Yang
Huafeng
H
Han
Dongxue
D
Zhang
Qixian
Q
Ivaska
Ari
A
Niu
Li
L
D001672:Biocompatible Materials / Q000737:chemistry* / Q000378:metabolism; D015374:Biosensing Techniques; D002244:Carbon / Q000737:chemistry*; D004563:Electrochemistry; D006735:Horseradish Peroxidase / Q000737:chemistry / Q000378:metabolism; D006861:Hydrogen Peroxide / Q000032:analysis; D053761:Nanocomposites / Q000737:chemistry; D011107:Polylysine / Q000737:chemistry* / Q000378:metabolism; D012995:Solubility; D013194:Staining and Labeling; D014867:Water / Q000737:chemistry*
D001672:Biocompatible Materials; D014867:Water; D011107:Polylysine; D002244:Carbon; D006861:Hydrogen Peroxide; D006735:Horseradish Peroxidase