title: Glutathione S-transferase M1 null genotype associated with gastric cancer among Asians.
abstract: OBJECTIVE
  The Glutathione S-transferases (GSTs) play multiple roles in the pathogenesis and treatment of cancer. Studies investigating the association between Glutathione S-transferase M1 (GSTM1) null genotype and gastric cancer risk report conflicting results. The purpose of this study was to quantitatively summarize the evidence for such a relationship.
  
  
  RESULTS
  This meta-analysis included 35 studies, which included 4,505 gastric cancer cases and 9,062 controls. The combined results based on all studies showed that the GSTM1 null genotype was associated with an increased risk of gastric cancer (OR = 1.15, 95% confidence interval [CI] = 1.02, 1.29). When stratifying for race, results were similar among Asians (OR = 1.24, 95% CI = 1.07, 1.44) except Caucasians (OR = 1.04, 95% CI = 0.88, 1.24). When stratifying by the location, stage, Lauren's classification, histological differentiation, lymph node metastasis, smoking, and Helicobacter pylori infection of gastric cancer, we observed that patients with diffuse classification had a significantly higher frequency null genotype (OR = 4.80, 95% CI = 1.65,13.94) than those with intestinal classification among Caucasians.
  
  
  CONCLUSIONS
  This meta-analysis suggests that the GSTM1 null genotype may be associated with gastric cancer among Asians.
authors.affiliation: Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China. doctorwanghong@gmail.com
authors.forename: Hong
authors.initials: H
authors.lastname: Wang
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhou
authors.forename: Wen
authors.initials: W
authors.lastname: Zhuang
authors.forename: Yi-Qiong
authors.initials: YQ
authors.lastname: Yin
authors.forename: Guan-Jian
authors.initials: GJ
authors.lastname: Liu
authors.forename: Tai-Xiang
authors.initials: TX
authors.lastname: Wu
authors.forename: Xun
authors.initials: X
authors.lastname: Yao
authors.forename: Liang
authors.initials: L
authors.lastname: Du
authors.forename: Mao-Ling
authors.initials: ML
authors.lastname: Wei
authors.forename: Xiao-Ting
authors.initials: XT
authors.lastname: Wu
mesh_terms: D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D020022:Genetic Predisposition to Disease / Q000453:epidemiology*; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D015994:Incidence; D008297:Male; D012150:Polymorphism, Restriction Fragment Length; D011379:Prognosis; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013274:Stomach Neoplasms / Q000453:epidemiology* / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D015996:Survival Rate
chemical_list: D005982:Glutathione Transferase