title: Intracranial blood-flow velocity and pressure measurements using an intra-arterial dual-sensor guidewire.
abstract: Hemodynamics is thought to play a role in the growth and rupture of intracranial aneurysms. In 4 patients, we obtained local pressure and BFV by using a dual-sensor pressure and Doppler velocity wire within and in vessels surrounding unruptured aneurysms. Local BFVs can serve as boundary conditions for computational fluid dynamics, whereas pressure recordings provide direct information on the mechanical load imposed on the aneurysm. Both measurements may thus add to patient-specific rupture-risk assessment.
authors.affiliation: Department of Radiology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands. s.p.ferns@amc.uva.nl
authors.forename: S P
authors.initials: SP
authors.lastname: Ferns
authors.forename: J J
authors.initials: JJ
authors.lastname: Schneiders
authors.forename: M
authors.initials: M
authors.lastname: Siebes
authors.forename: R
authors.initials: R
authors.lastname: van den Berg
authors.forename: E T
authors.initials: ET
authors.lastname: van Bavel
authors.forename: C B
authors.initials: CB
authors.lastname: Majoie
mesh_terms: D000368:Aged; D017542:Aneurysm, Ruptured / Q000453:epidemiology; D001783:Blood Flow Velocity / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology*; D002343:Carotid Artery, Internal; D002404:Catheterization / Q000295:instrumentation / Q000379:methods; D002560:Cerebrovascular Circulation / Q000502:physiology*; D004621:Embolization, Therapeutic; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D002532:Intracranial Aneurysm / Q000453:epidemiology / Q000503:physiopathology* / Q000628:therapy; D017078:Laser-Doppler Flowmetry / Q000295:instrumentation* / Q000379:methods*; D008875:Middle Aged; D011237:Predictive Value of Tests; D012307:Risk Factors