title: Animal models reveal role for tau phosphorylation in human disease.
abstract: Many proteins that are implicated in human disease are posttranslationally modified. This includes the microtubule-associated protein tau that is deposited in a hyperphosphorylated form in brains of Alzheimer's disease patients. The focus of this review article is on the physiological and pathological phosphorylation of tau; the relevance of aberrant phosphorylation for disease; the role of kinases and phosphatases in this process; its modeling in transgenic mice, flies, and worms; and implications of phosphorylation for therapeutic intervention.
authors.affiliation: Alzheimer's and Parkinson's Disease Laboratory, Brain and Mind Research Institute, University of Sydney, 100 Mallett Street, Camperdown, New South Wales 2050, Australia. jgoetz@med.usyd.edu.au
authors.forename: Jürgen
authors.initials: J
authors.lastname: Götz
authors.forename: Amadeus
authors.initials: A
authors.lastname: Gladbach
authors.forename: Luis
authors.initials: L
authors.lastname: Pennanen
authors.forename: Janet
authors.initials: J
authors.lastname: van Eersel
authors.forename: Andreas
authors.initials: A
authors.lastname: Schild
authors.forename: Della
authors.initials: D
authors.lastname: David
authors.forename: Lars M
authors.initials: LM
authors.lastname: Ittner
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D010766:Phosphorylation; D016875:tau Proteins / Q000502:physiology*
chemical_list: D016875:tau Proteins