title: [Optimal extraction of melampyrit from Euonymus fortunei by central composite design-response surface methodology].
abstract: OBJECTIVE
  To optimize the process of extracting melampyrit from Euonymus fortunei by central composite design-response surface methodology.
  
  
  METHODS
  The independent variables were the solvent fold and extractive time, and the dependent variable was the extraction rate of melampyrit from Euonymus fortunei. Then different mathematic models were used to estimate the relationship between the independent and dependent variables. The response surface methodology was used to optimize the process of extraction and the prediction was carried out through comparing the observed and predicted values.
  
  
  RESULTS
  The regression coefficient of binomial fitting complex model was 0.9515, and the optimum conditions of extraction process were 12-fold volume of solvent, 1.5 hours for decoction and 2 times for extraction. The bias between the observed and predicted values was -5.37%.
  
  
  CONCLUSIONS
  It shows that this method is convenient and the optimum model is highly predictive.
authors.affiliation: Faculty of Phamacy, Guangxi University of Traditional Chinese Medicine, Nanning 530001, China. wwj5101@hotmail.com
authors.forename: Wen-Jun
authors.initials: WJ
authors.lastname: Wei
authors.forename: Yan-Ping
authors.initials: YP
authors.lastname: Liu
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods; D029756:Euonymus / Q000737:chemistry*; D004376:Galactitol / Q000032:analysis / Q000302:isolation & purification*; D035261:Plant Components, Aerial / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D015203:Reproducibility of Results; D012997:Solvents / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods*; D013696:Temperature; D013997:Time Factors; D014867:Water / Q000737:chemistry
chemical_list: D012997:Solvents; D014867:Water; D004376:Galactitol