title: Previous vertebral compression fractures add to the deterioration of the disability and quality of life after an acute compression fracture.
abstract: Prevalent vertebral compression fracture(s) have been reported as having a negative impact on pain, disability, and quality of life. But no study has evaluated the effect of previous fracture on the course of acute compression fractures. The aim of the present study was to compare the natural course of the acute compression fracture in patients with (n = 51) and without (n = 56) previous vertebral compression fracture(s). The study is a retrospective analysis of a prospective cohort followed with postal questionnaires during a 12-month period after an acute fracture event. Eligible patients were those over 40 years of age, who were admitted to the emergency unit because of back pain and had an X-ray confirmed acute vertebral body fracture. A total of 107 patients were included in the study. The pain, disability (von Korff pain and disability scores), ADL (Hannover ADL score), and quality of life (QoL) (EQ-5D) were measured after 3 weeks, and 3, 6, and 12 months. The X-rays from the first visit to the emergency unit were evaluated. The difference of the scores between the groups with and without previous fracture was statistically significant (P < 0.05) at 3 weeks, 6 and 12 months for von Korff disability score, at all occasions for EQ-5D and at 3-12 months for Hannover ADL score, but only at 12 months for the von Korff pain intensity score. In both the groups all scores had improved in a statistically significant way at 3 months. The number of previous fractures was related to all the outcome scores in a statistically significant way (P < 0.05) except von Korff pain intensity score at 3 weeks and 3 months and von Korff disability score at 3 months. In conclusion, disability, ADL, and QoL scores, but not pain intensity score, were significantly worse in the patients with previous fracture from the fracture episode through the first 12 months. However, the improvements during the follow-up year seen in both groups were of a similar magnitude. The presence or absence of a previous fracture in an acutely fractured patient will influence the prognosis and thus possibly also the indications for treatments.
authors.affiliation: Department of Orthopaedic Surgery, Nagoya City University Graduate School of Medical Sciences, 1-Kawasumi, Mizuho-Cho, Mizuho-ku, Nagoya, Aichi 467-8601, Japan.
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Suzuki
authors.forename: Osamu
authors.initials: O
authors.lastname: Ogikubo
authors.forename: Tommy
authors.initials: T
authors.lastname: Hansson
mesh_terms: D000203:Activities of Daily Living / Q000523:psychology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D018450:Disease Progression; D050815:Fractures, Compression / Q000209:etiology / Q000523:psychology*; D006304:Health Status; D006801:Humans; D008159:Lumbar Vertebrae / Q000293:injuries; D008875:Middle Aged; D010024:Osteoporosis / Q000150:complications / Q000523:psychology*; D010146:Pain / Q000523:psychology; D010147:Pain Measurement; D017060:Patient Satisfaction; D011788:Quality of Life / Q000523:psychology*; D012189:Retrospective Studies; D012720:Severity of Illness Index; D016103:Spinal Fractures / Q000209:etiology / Q000523:psychology*; D018709:Statistics, Nonparametric; D011795:Surveys and Questionnaires; D013904:Thoracic Vertebrae / Q000293:injuries