[New diagnostic test for tuberculosis].
The performance of two commercially-available Interferon Gamma Release Assays, QuantiFERON-TB-Gold and T-SPOT-TB, is reviewed. The tests can indirectly detect M. tuberculosis infection based on T-cell recognition of specific proteins which are not present in the BCG vaccine M. avium, or most other environmental mycobacteria.The sensitivity (76-88%) of the IGRAs is not optimal for a diagnostic test for active tuberculosis. However, the specificity is high (92-97%), and the IGRAs may play an important role in the investigation for active tuberculosis and screening for latent tuberculosis infection in BCG vaccinated populations and immunosuppressed patients.
Ravn
Pernille
P
Infektionsmedicinsk Enhed, Medicinsk Afdeling O 107, Herlev Hospital, DK-2730 Herlev. pravn@dadlnet.dk
Rose
Michala Vaaben
MV
Søborg
Bolette
B
Andersen
Ase Bengård
AB
D000328:Adult; D015415:Biomarkers / Q000097:blood*; D002648:Child; D016358:Contact Tracing; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D016867:Immunocompromised Host; D007371:Interferon-gamma / Q000097:blood*; D009169:Mycobacterium tuberculosis / Q000276:immunology / Q000302:isolation & purification; D012307:Risk Factors; D012680:Sensitivity and Specificity; D014374:Tuberculin Test; D014376:Tuberculosis / Q000097:blood / Q000175:diagnosis*
D015415:Biomarkers; D007371:Interferon-gamma