title: The efficacy of preoperative hormonal therapy before laparoscopic cystectomy of ovarian endometriomas.
abstract: OBJECTIVE
  The aim of this study was to investigate the influence of preoperative hormonal therapy before laparoscopic cystectomy of ovarian endometriomas. We identified differences in follicle loss and surgical difficulties with or without preoperative hormonal therapy.
  
  
  METHODS
  Ninety-six patients with ovarian endometrioma underwent a laparoscopic cystectomy. Patients were divided into three groups: control group A (53 patients, 57 cysts) with no preoperative hormonal therapy; group B (34 patients, 40 cysts) who received gonadotropin-releasing hormone agonist therapy; and group C (9 patients, 11 cysts) who received danazol therapy before surgery. The medical and videotape records of all patients were retrospectively reviewed. The specimens of endometriomas were histologically evaluated.
  
  
  RESULTS
  Mean diameters of endometriomas before hormonal therapy in groups B and C were significantly greater than those in the control group. There were no significant differences in the following: the mean diameter of removed cysts, the revised-American Society of Reproductive Medicine scores, the number of capsules containing follicle(s), and the mean number of follicles attached to a cyst. However, the number of capsules showing fibrosis significantly increased in the preoperative hormonal therapy groups (P < 0.001). Furthermore, the mean operation time of the preoperative hormonal groups was significantly longer than that of the control group (P < 0.01, P < 0.001).
  
  
  CONCLUSIONS
  Our data suggested that preoperative hormonal therapy reduced the size of endometriomas. However, with similar revised-American Society of Reproductive Medicine scores, preoperative hormonal therapy did not contribute to the reduction of the loss of ovarian follicles. Fibrosis resulting from hormonal therapy appears to be responsible for these observations.
authors.affiliation: Department of Obstetrics and Gynecology, Fukuoka University Faculty of Medicine, Fukuoka, Japan. tsujioka@fukuoka-u.ac.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tsujioka
authors.forename: Yoshihito
authors.initials: Y
authors.lastname: Inoue
authors.forename: Makoto
authors.initials: M
authors.lastname: Emoto
authors.forename: Riko
authors.initials: R
authors.lastname: Sadamori
authors.forename: Kyoko
authors.initials: K
authors.lastname: Shirota
authors.forename: Toru
authors.initials: T
authors.lastname: Hachisuga
authors.forename: Tatsuhiko
authors.initials: T
authors.lastname: Kawarabayashi
mesh_terms: D000328:Adult; D003613:Danazol / Q000627:therapeutic use*; D004715:Endometriosis / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives / Q000627:therapeutic use*; D006801:Humans; D010535:Laparoscopy; D010049:Ovarian Diseases / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*
chemical_list: D007987:Gonadotropin-Releasing Hormone; D003613:Danazol