title: The effect of intranasal administration of oxytocin on fear recognition.
abstract: The oxytocinergic system has recently been placed amongst the most promising targets for various psychiatric treatments due to its role in prosocial behavior and anxiety reduction. Although recent studies have demonstrated a general effect of administration of oxytocin on emotion recognition, no study to date has examine the effect of oxytocin on each emotion separately. In the present study, a double-blind placebo-controlled crossover design was used in a dynamic facial expression task, in order to assess the effects of administration of oxytocin on emotion recognition. A single dose of oxytocin or a placebo was administered intranasally to 27 healthy male subjects 45 min prior to task performance. The results showed that a single intranasal administration of oxytocin, as opposed to the placebo, improved the subjects' ability to recognize fear, but not other emotions. These results suggest a specific role for oxytocin in fear recognition, which could be relevant for clinical disorders that manifest deficits in processing emotional facial expressions, particularly fear.
authors.affiliation: Department of Psychology, University of Haifa, Haifa 31905, Israel.
authors.forename: M
authors.initials: M
authors.lastname: Fischer-Shofty
authors.forename: S G
authors.initials: SG
authors.lastname: Shamay-Tsoory
authors.forename: H
authors.initials: H
authors.lastname: Harari
authors.forename: Y
authors.initials: Y
authors.lastname: Levkovitz
mesh_terms: D000281:Administration, Intranasal; D000328:Adult; D000339:Affect / Q000187:drug effects; D000704:Analysis of Variance; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005149:Facial Expression; D005239:Fear / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008297:Male; D010120:Oxytocics / Q000008:administration & dosage / Q000494:pharmacology*; D010121:Oxytocin / Q000008:administration & dosage / Q000494:pharmacology*; D010775:Photic Stimulation / Q000379:methods; D011930:Reaction Time / Q000187:drug effects; D021641:Recognition, Psychology / Q000187:drug effects* / Q000502:physiology; D055815:Young Adult
chemical_list: D010120:Oxytocics; D010121:Oxytocin