title: Locally advanced rectal cancer: from molecular profiling to clinical practice. A literature review: Part 2.
abstract: Colorectal cancer is the third most common cause of cancer deaths worldwide. The management of rectal cancer has undergone, and continues to undergo, significant evolutions. In the last two decades, new multimodality strategies have been developed. The ability to predict tumor response before treatment could significantly impact the selection of patients for preoperative combined-modality therapy, as well as potentially modify postoperative treatment plans. The present review analyzes the new molecular targets that could be involved in predicting response and prognosis.
authors.affiliation: Università Politecnica delle Marche, Azienda Ospedaliero-Universitaria Ospedali Riuniti Umberto I, GM Lancisi - G Salesi di Ancona, Medical Oncology Unit, 60020 Ancona, Italy. r.berardi@univpm.it
authors.forename: Rossana
authors.initials: R
authors.lastname: Berardi
authors.forename: Elena
authors.initials: E
authors.lastname: Maccaroni
authors.forename: Azzurra
authors.initials: A
authors.lastname: Onofri
authors.forename: Riccardo
authors.initials: R
authors.lastname: Giampieri
authors.forename: Mirco
authors.initials: M
authors.lastname: Pistelli
authors.forename: Alessandro
authors.initials: A
authors.lastname: Bittoni
authors.forename: Mario
authors.initials: M
authors.lastname: Scartozzi
authors.forename: Chiara
authors.initials: C
authors.lastname: Pierantoni
authors.forename: Alessandra
authors.initials: A
authors.lastname: Mandolesi
authors.forename: Italo
authors.initials: I
authors.lastname: Bearzi
authors.forename: Stefano
authors.initials: S
authors.lastname: Cascinu
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D014408:Biomarkers, Tumor / Q000378:metabolism; D002986:Clinical Trials as Topic; D016503:Drug Delivery Systems; D006801:Humans; D011237:Predictive Value of Tests; D011379:Prognosis; D012004:Rectal Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor