Photo-switching of vinylpyrene-substituted 2'-deoxyguanosine and its application.
We synthesized C8-vinylpyrene-substituted 2'-deoxyguanosine (VPy)G and studied the photoinduced reversible E-Z isomerization. When E-isomer was irradiated with visible light (>420 nm), E- to Z-isomerization took place very rapidly, while upon irradiation with UV-light ( approximately 365 nm), Z-isomer was converted to E-isomer. When Z-isomer was illuminated with 365- 400 nm light, no fluorescence was observed, while E-isomer showed a very strong fluorescence emission, indicating that (VPy)G could be a useful fluorescence switching molecule.
Saito
Yoshio
Y
Department of Materials Chemistry and Engineering and NEWCAT Institute, School of Engineering, Nihon University, Koriyama, Fukushima 963-8642, Japan. saito@chem.ce.nihon-u.ac.jp
Takeuchi
Yoshiki
Y
Matsumoto
Katsuhiko
K
Takahashi
Naoya
N
Suzuki
Azusa
A
Saito
Isao
I
D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000528:radiation effects; D007536:Isomerism; D009838:Oligodeoxyribonucleotides / Q000737:chemistry; D055668:Photochemical Processes; D011721:Pyrenes / Q000737:chemistry / Q000528:radiation effects; D013050:Spectrometry, Fluorescence; D013696:Temperature
D009838:Oligodeoxyribonucleotides; D011721:Pyrenes; D003849:Deoxyguanosine