title: Insulin resistance and C-reactive protein in preeclampsia.
abstract: Preeclampsia is referred to as the "disease of the theories" because of the multiple hypotheses proposed to explain is occurrence. Despite considerable research, the causes of preeclampsia remain unclear. Preeclampsia is likely to be multifactorial in origin, and recent research has focused on endothelial dysfunction as a central abnormality in preeclampsia. Insulin resistance and inflammation may contribute to the onset of preeclampsia. They could also be correlated. The aim of the study was to evaluate the presence and relationship between insulin resistance and its markers and C-reactive protein as a marker of inflammation. During their third trimester, 17 preeclamptic women and 20 normotensive controls underwent oral glucose tolerance test, basic biochemical analyses and SHBG. Preeclamptic women were more insulin resistant (p=0,004), and they had higher triglycerides levels (p=0,006), uric acid (p=0,002). However, the study groups did not differ in C-reactive protein (CRP), sex hormone-binding globulin (SHBG), high and low-density lipoproteins (HDL-cholesterol and LDL-cholesterol). In multiple regression analysis only SHBG (p=0,014) and triglycerides (p=0,003) were associated with insulin sensitivity independently of the body mass index (BMI), weight gain, HDL and LDL, and CRP. Preeclampsia is a state of increased insulin resistance, and CRP as the marker of inflammation was not increased in our research, and not associated with established preeclampsia.
authors.affiliation: Clinic of Gynecology and Obstetrics, Clinical Center Nis, Serbia.
authors.forename: Milan
authors.initials: M
authors.lastname: Stefanović
authors.forename: Predrag
authors.initials: P
authors.lastname: Vukomanović
authors.forename: Mileva
authors.initials: M
authors.lastname: Milosavljević
authors.forename: Ranko
authors.initials: R
authors.lastname: Kutlesić
authors.forename: Jasmina
authors.initials: J
authors.lastname: Popović
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Tubić-Pavlović
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism*; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL / Q000097:blood; D016208:Databases, Factual; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology*; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D011263:Pregnancy Trimester, Third / Q000097:blood; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism; D014280:Triglycerides / Q000097:blood; D014527:Uric Acid / Q000097:blood
chemical_list: D015415:Biomarkers; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D007328:Insulin; D012738:Sex Hormone-Binding Globulin; D014280:Triglycerides; D014527:Uric Acid; D002097:C-Reactive Protein