Polymorphisms in the protein C inhibitor gene in in vitro fertilization failure.
The aim of this study was to determine whether total fertilization failure in human IVF can be partially explained by alterations in the gene that codes for protein C inhibitor. Forty-six men had IVF total fertilization failure and 51 controls with normal fertilization were screened for mutations in the protein C inhibitor gene by direct sequencing. The main finding was that in men involved in total fertilization failure, a heterozygous adenosine/guanine (A/G) base combination in position 1389 (rs2069990) (exon 6) in the protein C inhibitor gene was significantly more common compared with controls (10.9% vs. 0).
Bungum
Mona
M
Reproductive Medicine Centre, Malmö University Hospital, Malmö, Sweden. mona.bungum@med.lu.se
Giwercman
Aleksander
A
Bungum
Leif
L
Humaidan
Peter
P
Rastkhani
Hamideh
H
Giwercman
Yvonne Lundberg
YL
D000328:Adult; D016022:Case-Control Studies; D005091:Exons; D005260:Female; D005307:Fertilization in Vitro; D005787:Gene Frequency; D006579:Heterozygote; D006801:Humans; D008297:Male; D010641:Phenotype; D010865:Pilot Projects; D020641:Polymorphism, Single Nucleotide; D018046:Protein C Inhibitor / Q000235:genetics*; D017211:Treatment Failure
D018046:Protein C Inhibitor; C534934:SERPINA5 protein, human