title: DNA vaccines against influenza viruses.
abstract: As an attractive alternative to conventional vaccines, DNA vaccines play a critical role in inducing protection against several infectious diseases. In this review, we discuss the advantages that DNA vaccines offer in comparison to conventional protein-based vaccines. We discuss strategies to improve the potency and efficacy of DNA vaccines. Specifically, we focus on the potential use of DNA-based vaccines to elicit broad-spectrum humoral and cellular immunity against influenza virus. Finally, we discuss the advances made in the use of DNA vaccines to prevent avian H5N1 influenza.
authors.affiliation: Department of Microbiology & Immunology and Emory Vaccine Center, School of Medicine, Emory University, 954 Gatewood Road, Atlanta, GA 30329, USA.
authors.forename: Jin Hyang
authors.initials: JH
authors.lastname: Kim
authors.forename: Joshy
authors.initials: J
authors.lastname: Jacob
mesh_terms: D000818:Animals; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology*; D053124:Influenza A Virus, H5N1 Subtype / Q000276:immunology*; D007252:Influenza Vaccines / Q000276:immunology*; D019444:Vaccines, DNA / Q000276:immunology*
chemical_list: D007252:Influenza Vaccines; D019444:Vaccines, DNA