Synthesis and thermal denaturation studies of covalently linked DNA triplexes.
We report on the synthesis and thermal stability of small covalently linked DNA triplexes. These modified triplexes were found to contain covalently linked T-T pairs at the edges, and thermal denaturation studies revealed that the covalent linking efficiently stabilized triplex formation.
Okamoto
Itaru
I
Department of Material and Life Chemistry, Faculty of Engineering, Kanagawa University, Yokohama 221-8686, Japan.
Ito
Shota
S
Ono
Takashi
T
Ono
Akira
A
D004247:DNA / Q000138:chemical synthesis / Q000737:chemistry*; D009691:Nucleic Acid Denaturation; D009838:Oligodeoxyribonucleotides / Q000737:chemistry; D013816:Thermodynamics
D009838:Oligodeoxyribonucleotides; C051802:triplex DNA; D004247:DNA