Use of clofazimine in dermatology.
Clofazimine is the riminophenazine dye that, due to its antibacterial and anti-inflammatory properties, has been used for several diseases. This article reviews all major characteristics and uses relating to clofazimine, from its pharmacology to its indications in several skin diseases, over and above its classical and well established use in the treatment of leprosy. Due to its anti-inflammatory and antimicrobial properties, clofazimine has a wide spectrum for application in dermatology. The indications include neutrophilic, granulomatous and infectious diseases. Although it is not the first-choice medication in most of the cases, clofazimine should always be considered among the therapeutic options in refractory cases.
Gurfinkel
Paula
P
Sector of Dermatology and Post-Graduation Course, HUCFF-UFRJ and School of Medicine, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Pina
Juliana Carnevale
JC
Ramos-e-Silva
Marcia
M
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D002991:Clofazimine / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D007917:Leprostatic Agents / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D012871:Skin Diseases / Q000188:drug therapy* / Q000503:physiopathology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007917:Leprostatic Agents; D002991:Clofazimine