The effectiveness of Proctofoam-HC for treatment of hemorrhoids in late pregnancy.
OBJECTIVE
Currently no topical anti-hemorrhoidal agents have been studied for effectiveness in pregnancy. This study evaluated the effectiveness of Proctofoam-HC used during the last trimester of pregnancy.


METHODS
In this prospective, open-label, observational study, pregnant women prescribed Proctofoam-HC were asked to complete two telephone interview questionnaires.


RESULTS
A total of 88 women completed the study. All hemorrhoidal symptoms, including pain, pruritus, swelling, itching, decreased significantly (P < 0.001) and overall well-being improved. The improvement was clinically very significant after correction for potential placebo effect.


CONCLUSIONS
Proctofoam-HC appears to provide effective treatment of hemorrhoids in late pregnancy.
Vohra
Sabina
S
The Motherisk Program, Hospital for Sick Children, Toronto, ON, Canada.
Akoury
Hani
H
Bernstein
Paul
P
Einarson
Thomas R
TR
Pairaudeau
Nicholas
N
Taddio
Anna
A
Koren
Gideon
G
D000287:Administration, Topical; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D004338:Drug Combinations; D005260:Female; D006484:Hemorrhoids / Q000188:drug therapy*; D006801:Humans; D006854:Hydrocortisone / Q000627:therapeutic use*; D009025:Morpholines / Q000627:therapeutic use*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D011446:Prospective Studies
D000893:Anti-Inflammatory Agents; D004338:Drug Combinations; D009025:Morpholines; C009046:proctofoam-HC; D006854:Hydrocortisone