title: Risk of mesothelioma and occupational exposure to asbestos and man-made vitreous fibers: evidence from two case-control studies in Montreal, Canada.
abstract: OBJECTIVE
  To examine the effects of exposure to occupational asbestos and man-made vitreous fibers (MMVF) across a wide range of occupations on risk of mesothelioma.
  
  
  METHODS
  Two population-based case-control studies (1979-1986 and 1996-2001) provided 35 histologically confirmed mesothelioma cases and 1965 controls. A detailed job history was obtained to evaluate occupational exposure to many agents, including asbestos and MMVF.
  
  
  RESULTS
  The mesothelioma odds ratio for exposure to any asbestos type was 3.7 (95% confidence interval = 1.7 to 7.8). The subset exposed to amphibole fibers experienced an odds ratio = 7.0 (95% confidence interval = 2.7 to 18.5). Effects of MMVF could not be disentangled from those of asbestos.
  
  
  CONCLUSIONS
  In workers with exposure levels lower than in most historical cohort studies and across a wide range of industries, a strong association was found between asbestos, especially when it was amphibole, and mesothelioma.
authors.affiliation: INRS-Institut Armand-Frappier, Unit of Epidemiology and Biostatistics, Laval, Quebec, Canada. javier.pintos@iaf.inrs.ca
authors.forename: Javier
authors.initials: J
authors.lastname: Pintos
authors.forename: Marie-Elise
authors.initials: ME
authors.lastname: Parent
authors.forename: Bruce W
authors.initials: BW
authors.lastname: Case
authors.forename: Marie-Claude
authors.initials: MC
authors.lastname: Rousseau
authors.forename: Jack
authors.initials: J
authors.lastname: Siemiatycki
mesh_terms: D000328:Adult; D000368:Aged; D001194:Asbestos / Q000009:adverse effects*; D016022:Case-Control Studies; D005260:Female; D005898:Glass; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology*; D008297:Male; D008654:Mesothelioma / Q000209:etiology*; D008875:Middle Aged; D019016:Mineral Fibers / Q000009:adverse effects*; D016273:Occupational Exposure / Q000009:adverse effects*; D016017:Odds Ratio; D011792:Quebec
chemical_list: D019016:Mineral Fibers; C009753:fiberglass; D001194:Asbestos