Degradation of cytoplasmic substrates by FtsH, a membrane-anchored protease with many talents.
Control of cellular processes by regulated proteolysis is conserved among all organisms. FtsH, the only membrane-anchored AAA protease in bacteria, fulfills a variety of regulatory functions. This review focuses on soluble FtsH substrates in Escherichia coli and in other bacteria and outlines emerging substrate recognition principles.
Narberhaus
Franz
F
Ruhr-Universität Bochum, Lehrstuhl für Biologie der Mikroorganismen, Bochum, Germany. franz.narberhaus@rub.de
Obrist
Markus
M
Führer
Frank
F
Langklotz
Sina
S
D049069:ATP-Dependent Proteases / Q000737:chemistry / Q000378:metabolism*; D000581:Amidohydrolases / Q000378:metabolism; D055162:Biocatalysis; D002462:Cell Membrane / Q000201:enzymology*; D003593:Cytoplasm / Q000201:enzymology*; D029968:Escherichia coli Proteins / Q000737:chemistry / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism; D013379:Substrate Specificity
D029968:Escherichia coli Proteins; D008565:Membrane Proteins; D049069:ATP-Dependent Proteases; C513383:FtsH protein, E coli; D000581:Amidohydrolases; C097307:UDP-3-O-acyl-N-acetylglucosamine deacetylase