Airway obstruction is increased in pneumocystis-colonized human immunodeficiency virus-infected outpatients.
We investigated the relationship of Pneumocystis colonization, matrix metalloprotease levels in sputum, and airway obstruction in a cohort of human immunodeficiency virus (HIV)-infected outpatients. Pneumocystis-colonized subjects had worse obstruction of airways and higher levels of matrix metalloprotease-12 in sputa, suggesting that Pneumocystis colonization may be important in HIV-associated chronic obstructive pulmonary disease.
Morris
Alison
A
University of Pittsburgh Medical Center, 628 NW MUH, 3459 Fifth Avenue, Pittsburgh, PA 15213, USA. morrisa@upmc.edu
Alexander
Travis
T
Radhi
Saba
S
Lucht
Lorrie
L
Sciurba
Frank C
FC
Kolls
Jay K
JK
Srivastava
Ruma
R
Steele
Chad
C
Norris
Karen A
KA
D000328:Adult; D000368:Aged; D000402:Airway Obstruction / Q000382:microbiology* / Q000473:pathology*; D015331:Cohort Studies; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008297:Male; D053508:Matrix Metalloproteinase 12 / Q000032:analysis; D008875:Middle Aged; D010045:Outpatients; D011010:Pneumocystis / Q000302:isolation & purification*; D016720:Pneumocystis Infections / Q000382:microbiology* / Q000473:pathology*; D013183:Sputum / Q000737:chemistry
D053508:Matrix Metalloproteinase 12