title: Zeta-crystallin: a tale of two cells.
abstract: Szutkowska et al. demonstrate that zeta-crystallin plays an essential role in the stabilization of the Na(+)/K(+)/2Cl(-) cotransporter mRNA in the medullary thick ascending limb. However, differential effects of experiments using small interfering RNA to knock down zeta-crystallin in proximal tubule and thick ascending limb cells suggest that additional proteins must contribute to the rapid turnover and selective stabilization of the various mRNAs during metabolic acidosis.
authors.affiliation: Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, Colorado 80523-1870, USA. Norman.Curthoys@Colostate.edu
authors.forename: Norman P
authors.initials: NP
authors.lastname: Curthoys
mesh_terms: D000138:Acidosis / Q000235:genetics*; D000818:Animals; D006801:Humans; D007679:Kidney Medulla; D007687:Kidney Tubules, Proximal; D020871:RNA Stability; D034741:RNA, Small Interfering; D028021:Sodium-Potassium-Chloride Symporters / Q000235:genetics; D038226:zeta-Crystallins / Q000502:physiology*
chemical_list: D034741:RNA, Small Interfering; D028021:Sodium-Potassium-Chloride Symporters; D038226:zeta-Crystallins