title: Tight junction proteins and signal transduction pathways in hepatocytes.
abstract: Tight junctions of hepatocytes play crucial roles in the barrier to keep bile in bile canaliculi away from the blood circulation, which we call the blood-billiary-barrier (Kojima et al., 2003). Tight junction proteins of hepatocytes are regulated by various cytokines and growth factors via distinct signal transduction pathways. They are also considered to participate in signal transduction pathways that regulate epithelial cell proliferation, gene expression, differentiation and morphogenesis. This review focuses on recent findings about the relationship between tight junction proteins and signal transduction pathways in hepatocytes.
authors.affiliation: Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan. ktakashi@sapmed.ac.jp
authors.forename: Takashi
authors.initials: T
authors.lastname: Kojima
authors.forename: Masaki
authors.initials: M
authors.lastname: Murata
authors.forename: Toshinobu
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Mengdong
authors.initials: M
authors.lastname: Lan
authors.forename: Masafumi
authors.initials: M
authors.lastname: Imamura
authors.forename: Seiichi
authors.initials: S
authors.lastname: Son
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Takano
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yamaguchi
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Ito
authors.forename: Satoshi
authors.initials: S
authors.lastname: Tanaka
authors.forename: Hideki
authors.initials: H
authors.lastname: Chiba
authors.forename: Koichi
authors.initials: K
authors.lastname: Hirata
authors.forename: Norimasa
authors.initials: N
authors.lastname: Sawada
mesh_terms: D000818:Animals; D022781:Hepatocytes / Q000378:metabolism*; D006801:Humans; D008565:Membrane Proteins / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D019108:Tight Junctions / Q000502:physiology*
chemical_list: D008565:Membrane Proteins