title: Witch hunt against tumor cells enhanced by dendritic cells.
abstract: Conventional cancer treatments mediate their effects via the direct elimination of tumor cells. Nonetheless, recent evidence indicates that radiotherapy and some chemotherapeutic agents can also induce specific immune responses that contribute to therapeutic outcomes. Two major tumor-intrinsic changes that determine the immune response against tumors have been identified: the translocation of calreticulin to the plasma membrane and the release of high-mobility group box 1 protein. Together, these changes improve engulfment and processing of apoptotic bodies by dendritic cells, which are involved in the cross-priming of antitumor T lymphocytes in vivo. We review these two molecular mechanisms that dictate the radio/chemotherapy-elicited antitumor immune response and discuss how this knowledge can be clinically exploited to predict and also ameliorate the success of chemo/radiotherapy.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale, U805, Villejuif, France.
authors.forename: Clara
authors.initials: C
authors.lastname: Locher
authors.forename: Sylvie
authors.initials: S
authors.lastname: Rusakiewicz
authors.forename: Antoine
authors.initials: A
authors.lastname: Tesnière
authors.forename: François
authors.initials: F
authors.lastname: Ghiringhelli
authors.forename: Lionel
authors.initials: L
authors.lastname: Apetoh
authors.forename: Guido
authors.initials: G
authors.lastname: Kroemer
authors.forename: Laurence
authors.initials: L
authors.lastname: Zitvogel
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D017209:Apoptosis; D016923:Cell Death / Q000276:immunology; D003131:Combined Modality Therapy; D003713:Dendritic Cells / Q000276:immunology*; D004195:Disease Models, Animal; D004721:Endoplasmic Reticulum / Q000276:immunology; D024243:HMGB1 Protein / Q000276:immunology; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009369:Neoplasms / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D010587:Phagocytosis; D019704:Protein Disulfide-Isomerases / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D000970:Antineoplastic Agents; D024243:HMGB1 Protein; D019704:Protein Disulfide-Isomerases; C085868:PDIA3 protein, human