Arachidonic acid supplementation decreases P300 latency and increases P300 amplitude of event-related potentials in healthy elderly men.
In the present study, we examined the effects of arachidonic acid (ARA) on age-related event-related potential (ERP) changes in 25 healthy elderly men. This study was performed using a double-blind crossover design. The subjects were administered 600 mg/day of ARA-enriched triglyceride (SUNTGA40S; containing 240 mg ARA) in capsules or the same amount of olive oil in capsules as an inactive placebo for 1 month. ERPs were measured before capsule administration and after 1 month of administration, and P300 latency and amplitude were also measured. In subjects administered 240 mg/day ARA, P300 latency was significantly shorter, and P300 amplitude was significantly higher than in those administered olive oil capsules, and they exhibited a significant increase in ARA content in serum phospholipids. These findings suggest that supplementation of ARA can improve cognitive function in healthy elderly men.
Ishikura
Yoshiyuki
Y
Institute for Health Care Science, Suntory Ltd., Osaka, Japan. Yoshiyuki_Ishikura@suntory.co.jp
Ikeda
Gakuro
G
Akimoto
Kengo
K
Hata
Mie
M
Kusumoto
Aki
A
Kidokoro
Ayako
A
Kontani
Masanori
M
Kawashima
Hiroshi
H
Kiso
Yoshinobu
Y
Koga
Yoshihiko
Y
D000368:Aged; D000704:Analysis of Variance; D016718:Arachidonic Acid / Q000008:administration & dosage* / Q000097:blood; D001921:Brain / Q000187:drug effects* / Q000502:physiology; D003071:Cognition / Q000187:drug effects* / Q000502:physiology; D018592:Cross-Over Studies; D019587:Dietary Supplements; D004311:Double-Blind Method; D004569:Electroencephalography; D018913:Event-Related Potentials, P300 / Q000187:drug effects*; D005227:Fatty Acids / Q000008:administration & dosage / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D018697:Nootropic Agents / Q000008:administration & dosage* / Q000097:blood; D013997:Time Factors
D005227:Fatty Acids; D018697:Nootropic Agents; D016718:Arachidonic Acid