title: Short communication: progression of Johne's disease curtailed by a probiotic.
abstract: The naturally occurring inflammatory bowel disease Johne's, caused by Mycobacterium avium ssp. paratuberculosis (MAP), has many clinical manifestations in common with the human inflammatory bowel disease Crohn's disease. In addition, both lack preventive and curative therapies. Because a high percentage of Crohn's patients harbor MAP, it is not surprising that MAP is at the center of controversy as to its contribution. Special concern is being raised as to what role, if any, food animals play in transmission of MAP to humans. Because management practices, presently considered the best way to control the spread of MAP, have not and most likely will not eliminate MAP from food animals, other preventive or curative measures are needed. The results presented herein show that a unique bacterium, Dietzia ssp. C79793-74, used as a probiotic, was therapeutic for adult paratuberculosis animals, and resulted in a cure rate of 37.5%.
authors.affiliation: University of Wisconsin-River Falls, River Falls 54022, USA. mbclicker@msn.com
authors.forename: R E
authors.initials: RE
authors.lastname: Click
authors.forename: C L
authors.initials: CL
authors.lastname: Van Kampen
mesh_terms: D000192:Actinomycetales; D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000175:diagnosis / Q000382:microbiology / Q000628:therapy*; D004797:Enzyme-Linked Immunosorbent Assay; D005243:Feces / Q000382:microbiology; D005260:Female; D005779:Immunodiffusion; D016927:Mycobacterium avium subsp. paratuberculosis / Q000254:growth & development / Q000302:isolation & purification; D010283:Paratuberculosis / Q000175:diagnosis / Q000382:microbiology / Q000628:therapy*; D019936:Probiotics / Q000627:therapeutic use*