title: Prognostic impact of the width of subserosal invasion in gastric cancer invading the subserosal layer.
abstract: BACKGROUND
  The depth of wall invasion is one of the most important prognostic factors in patients with gastric cancers. We hypothesized that the horizontal width of spread of the neoplasm in the subserosal layer correlated with frequency of latent tumor exposure to the subserosal surface in subserosal (ss) gastric cancer.
  
  
  METHODS
  We compared retrospectively the relationship between the horizontal width of ss invasion and other clinicopathologic factors in 124 patients with ss cancer confirmed carefully to have T2 and not T3 neoplasms. Selected clinicopathologic parameters of these ss patients were compared to 134 patients with serosal penetration (se) by gastric cancer, and 78 patients with invasion of the muscularis propria only (mp).
  
  
  RESULTS
  The width of ss invasion was found to be an important prognostic factor on both univariate (P < .001) and multivariate analyses (P = .006). The prognosis of ss-cancer with narrow-width invasion (less than 20 mm) was similar to that of mp-cancer, while the prognosis of ss-cancer with wide width (more than 20 mm) was similar to that of se-cancer.
  
  
  CONCLUSIONS
  Our findings showed that narrow-width ss-cancer (<20 mm) behaved very similar to mp-cancers, while wide ss-cancers (> or =20 mm) behaved very similar to se-cancers. These findings demonstrated the prognostic impact of the width of cancer invasion in subserosal layer in patients with ss-cancer. Intensive chemotherapy and close follow-up should be recommended for ss-cancer patients with greater than 20 mm involvement of the subserosal layer.
authors.affiliation: Division of Digestive Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Soga
authors.forename: Daisuke
authors.initials: D
authors.lastname: Ichikawa
authors.forename: Satoru
authors.initials: S
authors.lastname: Yasukawa
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kubota
authors.forename: Shojiro
authors.initials: S
authors.lastname: Kikuchi
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Fujiwara
authors.forename: Kazuma
authors.initials: K
authors.lastname: Okamoto
authors.forename: Toshiya
authors.initials: T
authors.lastname: Ochiai
authors.forename: Chohei
authors.initials: C
authors.lastname: Sakakura
authors.forename: Yukihito
authors.initials: Y
authors.lastname: Kokuba
authors.forename: Akio
authors.initials: A
authors.lastname: Yanagisawa
authors.forename: Eigo
authors.initials: E
authors.lastname: Otsuji
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005743:Gastrectomy; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011379:Prognosis; D012704:Serous Membrane / Q000473:pathology*; D013274:Stomach Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D015996:Survival Rate