Lipid profile in patients with psoriasis presenting at Liaquat University Hospital Hyderabad.
OBJECTIVE
To determine the lipid abnormalities in patients with psoriasis and compare it with healthy controls.


METHODS
Across-sectional controlled study was conducted at the Department of Dermatology Liaquat University Hospital Hyderabad from January 2007 to November 2007. The study included 158 consecutive patients; among which 88 were males (44 patients and 44 controls) and 70 females (35 patients and 35 controls). The patients with psoriasis having less than 30% body involvement were included in the study. Patients with severe psoriasis, high BMI (.30 kg/m2), hypertension, diabetes, smoking, alcohol consumption and personal or family history of hyperlipedemia were excluded. The patients were examined clinically and findings recorded on a pre-designed proforma. Fasting lipids were measured using SELECTRA XL chemistry analyzer using Spin react kits (made in Spain) by direct method.


RESULTS
All patients had psoriasis involving less than 30% of body surface. Their ages ranged from 18 years to 68 years (mean 37 +/- 7.96 years). Family history of disease was positive in 10 (6.32%) patients. 134 (84.8%) had plaque type psoriasis, 10 (6%) had in addition scalp and nail involvement, 05 (3.16%) guttate lesions, 05 (3.16%) had palmoplantar lesions while remaining 04 (2.43%) comprised of hyperkeratotic and flexural psoriasis. The duration of disease ranged between 18 months to 10 years with a mean of 4.5 +/- 1.89 years. Serum cholesterol, triglycerides and low density lipoprotein (LDL) cholesterol were significantly higher than in the normal control group (P < 0.01). There was no significant statistical difference in serum levels of very low density lipoprotein cholesterol (VLDL) and high density lipoprotein cholesterol (HDL-C) between the two groups.


CONCLUSIONS
Psoriasis is an independent risk factor for hyperlipidaemia and its possible subsequent sequelae such as obstructive vascular disease.
Bajaj
Doulat Rai
DR
Department of Dermatology, Liaquat University of Medical & Health Sciences, Jamshoro, Hyderabad.
Mahesar
Shah Muhammad
SM
Devrajani
Bekha Ram
BR
Iqbal
Muhammad Pervaiz
MP
D000293:Adolescent; D000328:Adult; D000368:Aged; D015992:Body Mass Index; D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D015243:Cholesterol, VLDL / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D006785:Hospitals, University; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000453:epidemiology*; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010154:Pakistan / Q000453:epidemiology; D011565:Psoriasis / Q000097:blood* / Q000453:epidemiology; D012307:Risk Factors; D012720:Severity of Illness Index; D012737:Sex Factors; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D015243:Cholesterol, VLDL; D008055:Lipids; D014280:Triglycerides