title: Atherosclerosis regression study in rabbits upon olive pomace polar lipid extract administration.
abstract: OBJECTIVE
  Virgin olive oil polar lipid extract (OOPL) and olive pomace polar lipid extract (PPL) have similar antiatherosclerotic effects in cholesterol-fed rabbits. Our aim was to compare the effect of PPL with that of simvastatin on the progression of atherogenesis.
  
  
  RESULTS
  Rabbits were fed an atherogenic diet for 6 weeks in order to develop dyslipidemia and atheromatous lesions. Following documentation of these events in random animals (group A, n=6), the remaining were fed for 3 weeks with: standard chow alone (group B, n=6), chow supplemented with PPL (group C, n=6), and chow supplemented with simvastatin (group D, n=6). Blood was collected at 0, 6 and 9 weeks, to determine plasma lipid levels, plasma PAF-AH activity, platelet aggregation (PAF-EC(50)), resistance of plasma to oxidation (RPO) and extent of atheromatous lesions in aortas. The atherogenic diet induced dyslipidemia and increased PAF-AH activity. Dyslipidemia and PAF-activity reduced more effectively in groups C and D. RPO decreased in group B only. PAF-EC(50) values decreased in group C only. Atherogenesis progression in group C was prevented to an extent indistinguishable from that in group D. PAF-AH activity was positively correlated, whereas RPO was negatively correlated with the extent of atheromatous lesions.
  
  
  CONCLUSIONS
  PPL, as a dietary supplement, is equipotent to simvastatin in preventing the progression of atherogenesis.
authors.affiliation: Faculty of Chemistry, National and Kapodistrian University of Athens, Athens, Greece.
authors.forename: N
authors.initials: N
authors.lastname: Tsantila
authors.forename: H C
authors.initials: HC
authors.lastname: Karantonis
authors.forename: D N
authors.initials: DN
authors.lastname: Perrea
authors.forename: S E
authors.initials: SE
authors.lastname: Theocharis
authors.forename: D G
authors.initials: DG
authors.lastname: Iliopoulos
authors.forename: C
authors.initials: C
authors.lastname: Iatrou
authors.forename: S
authors.initials: S
authors.lastname: Antonopoulou
authors.forename: C A
authors.initials: CA
authors.lastname: Demopoulos
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D050197:Atherosclerosis / Q000517:prevention & control*; D002784:Cholesterol / Q000097:blood*; D004036:Diet, Atherogenic; D019587:Dietary Supplements; D004195:Disease Models, Animal; D050171:Dyslipidemias / Q000378:metabolism; D008297:Male; D031658:Olea / Q000737:chemistry*; D000069463:Olive Oil; D010938:Plant Oils / Q000494:pharmacology*; D010974:Platelet Aggregation; D011817:Rabbits; D012044:Regression Analysis; D019821:Simvastatin / Q000494:pharmacology
chemical_list: D000069463:Olive Oil; D010938:Plant Oils; D002784:Cholesterol; D019821:Simvastatin