Impact of antiepileptic drugs on cognition, behavior, and motor skills in children with new-onset, idiopathic epilepsy.
OBJECTIVE
As treatment options for epilepsy have increased, there has been a commensurate increase in interest in the side effect profiles of these drugs.


METHODS
In this study, children between the ages of 6 and 17 with a diagnosis of new-onset, idiopathic epilepsy were evaluated at baseline (n=57) and 6 (n=45) and 12 (n=31) months after initiation of antiepileptic drug therapy.


RESULTS
There was improvement in the cognitive functioning of children after 12 months of treatment. A transient drop in performance of children with generalized seizures (10 of 11 of whom had absence seizures) at 6 months may have been due to persistent seizures, the drugs used to treat them (predominantly ethosuximide), or both. Worsening of reaction time and reaction time variability in the focal seizure group, the only scores showing persistent deterioration over 12 months, may be attributable to the medications used for this group, the most common of which was carbamazepine.


CONCLUSIONS
There were few adverse effects of antiepileptic drug treatment in the group followed over 12 months. Carbamazepine may have been responsible for persistent impairment of reaction time and reaction time variability.
Mandelbaum
David E
DE
Division of Child Neurology, Departments of Neurology and Pediatrics, Alpert Medical School of Brown University, Providence, RI 02903, USA. David_Mandelbaum@brown.edu
Burack
Gail D
GD
Bhise
Vikram V
VV
D000293:Adolescent; D000704:Analysis of Variance; D000927:Anticonvulsants / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use*; D002648:Child; D003071:Cognition / Q000187:drug effects*; D004827:Epilepsy / Q000145:classification / Q000150:complications / Q000188:drug therapy; D005260:Female; D006801:Humans; D007360:Intelligence; D008297:Male; D009048:Motor Skills / Q000187:drug effects*; D009483:Neuropsychological Tests; D011930:Reaction Time / Q000187:drug effects; D012189:Retrospective Studies; D013997:Time Factors; D014705:Verbal Behavior / Q000187:drug effects*
D000927:Anticonvulsants