Safety and benefits of a tablet combining losartan and hydrochlorothiazide in Japanese diabetic patients with hypertension.
This study was conducted to determine the effects of a tablet combining losartan/hydrochlorothiazide (L/HCTZ) in comparison with losartan alone in Japanese diabetic patients with hypertension. Thirty consecutive Japanese diabetic patients with hypertension were randomly assigned to group A, receiving losartan alone for the first 3 months, then L/HCTZ for the next 3 months, or group B, receiving L/HCTZ for the first 3 months, then losartan alone for the next 3 months. Clinical and biological parameters were obtained before, and 3 and 6 months after the start of this study. The decreases in systolic and diastolic blood pressure (BP) during treatment with L/HCTZ were significantly greater than in treatment with losartan alone. Both treatments significantly and similarly decreased urinary albumin excretion, the cardio-ankle vascular index (CAVI) and augmentation index (AI). There was no significant difference in metabolic change during both the mono- and combination pharmacotherapies. The tablet combining L/HCTZ significantly reduced systolic and diastolic BP compared with the losartan monotherapy, and offered benefits similar to losartan monotherapy for albuminuria, arterial stiffness assessed by the CAVI and AI, and metabolic effects. Thus, the L/HCTZ tablet could be a useful drug for Japanese diabetic patients with hypertension.
Kinouchi
Kenichiro
K
Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
Ichihara
Atsuhiro
A
Sakoda
Mariyo
M
Kurauchi-Mito
Asako
A
Itoh
Hiroshi
H
D000328:Adult; D000419:Albuminuria / Q000150:complications; D000450:Aldosterone / Q000097:blood; D000959:Antihypertensive Agents / Q000008:administration & dosage* / Q000009:adverse effects; D044466:Asian People; D001794:Blood Pressure / Q000187:drug effects; D018592:Cross-Over Studies; D048909:Diabetes Complications; D004338:Drug Combinations; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000008:administration & dosage* / Q000009:adverse effects; D006973:Hypertension / Q000150:complications* / Q000188:drug therapy*; D019808:Losartan / Q000008:administration & dosage* / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood; D012083:Renin / Q000097:blood; D013607:Tablets; D016896:Treatment Outcome
D000959:Antihypertensive Agents; D004338:Drug Combinations; D013607:Tablets; D006852:Hydrochlorothiazide; D020097:Natriuretic Peptide, Brain; D000450:Aldosterone; D012083:Renin; D019808:Losartan