[Biocompatibility of new bone tissue engineering scaffolds in vivo].
OBJECTIVE
To investigate the biocompatibility of new bone tissue engineering scaffolds, A:D, L-polylactic acid (PDLLA)/polylactic acid-polyethylene glycol-polylactic acid-polylactic acid (PLA-PEG-PLA)/Tricalcium phosphate and B: PDLLA/PLA-PEG-PLA in vivo, compared with PDLLA in repair of a rabbit mandibular body defect.


METHODS
24 New Zealand adult rabbits were divided into 4 groups randomly. 15 mm x 6 mm defects were made surgically in the bilateral mandibular bodies and each hemi-mandible was assigned as an experimental unit. The defects were randomly repaired with scaffold materials in each group. Specimens obtained were evaluated with general observation, X-ray, histomorphology and computerized graphical analysis at 2, 4 , 8, 12 weeks after surgery.


RESULTS
Compared with PDLLA, the new scaffold materials B showed biocompatibility. At the same time the quantity of new bone produced was much more than that in control group (P<0.05). The new scaffold materials A showed the clear chronic granulomatous inflammation.


CONCLUSIONS
New scaffold material B had sound biocompatibility. It was much better than PDLLA. So it may be an ideal bone tissue engineering scaffold material. A is not adapted to be used as scaffold material.
Li
Yi
Y
Dept. of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405, China.
Ran
Wei
W
Wang
Gai-ling
GL
Jing
Xiang-dong
XD
D000818:Animals; D001672:Biocompatible Materials; D001842:Bone and Bones; D002130:Calcium Phosphates; D007773:Lactates; D019344:Lactic Acid; D011091:Polyesters; D011092:Polyethylene Glycols; D011108:Polymers; D011817:Rabbits; D023822:Tissue Engineering; D054457:Tissue Scaffolds
D001672:Biocompatible Materials; D002130:Calcium Phosphates; D007773:Lactates; D011091:Polyesters; D011108:Polymers; C088513:poly(lactic acid-ethylene glycol); C507889:polylactide-polyethylene glycol-polylactide; D019344:Lactic Acid; D011092:Polyethylene Glycols; C033616:poly(lactide); C018392:tricalcium phosphate