title: Milk consumption and circulating insulin-like growth factor-I level: a systematic literature review.
abstract: Studies suggest that the circulating insulin-like growth factor I (IGF-I) level is positively associated with the prostate cancer risk. The association of milk consumption and circulating IGF-I level has been examined in epidemiological studies with inconsistent results. We conducted a systematic literature review to summarize and quantify the current evidence for milk or dairy product consumption and the circulating IGF-I level. We searched relevant papers published in English up to March 2009 in various databases. Fifteen cross-sectional studies and eight randomized controlled trials were finally identified. Ten cross-sectional studies showed statistically positive correlation between milk consumption and the circulating IGF-I level. Randomized controlled trials indicated that the circulating IGF-I level was significantly higher in the milk intervention group. After meta-analysis, the weighted mean difference of the circulating IGF-I level was 13.8 ng/ml (95% confidence interval: 6.1-21.5 ng/ml) comparing the intervention group with the control group. The current evidence suggests that milk consumption may increase the circulating IGF-I level.
authors.affiliation: Department of Nutrition and Food Hygiene, School of Radiation Medicine and Public Health, Medical College of Soochow University, Suzhou, China. qinliqiang@suda.edu.cn
authors.forename: Li-Qiang
authors.initials: LQ
authors.lastname: Qin
authors.forename: Ka
authors.initials: K
authors.lastname: He
authors.forename: Jia-Ying
authors.initials: JY
authors.lastname: Xu
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000453:epidemiology; D003611:Dairy Products; D005260:Female; D006133:Growth Substances / Q000097:blood / Q000502:physiology; D006801:Humans; D018969:Insulin-Like Growth Factor Binding Proteins / Q000097:blood / Q000378:metabolism; D007334:Insulin-Like Growth Factor I / Q000032:analysis* / Q000502:physiology; D008297:Male; D008892:Milk / Q000737:chemistry; D011471:Prostatic Neoplasms / Q000453:epidemiology; D012307:Risk Factors
chemical_list: D006133:Growth Substances; D018969:Insulin-Like Growth Factor Binding Proteins; D007334:Insulin-Like Growth Factor I