[Disturbances of primary hemostasis in patients with dilation cardiomyopathy].
We studied morphological characteristics of platelets and parameters of platelet aggregation in patients with dilation cardiomyopathy. Augmented aggregatory activity of platelets was found in 76% of patients. In blood of majority of patients we found circulating leukocyte-platelet aggregates. This evidenced for development of inflammatory process and could be related to disturbances of blood rheology. In 2 patients examined by virusological method we revealed presence of a virus inside platelets. This phenomenon might serve as one of possible pathological pathways of disease progression at the account of spread of viral infection along vascular bed during thrombus formation.
Sumarokov
A B
AB
Buriachkovskaia
L I
LI
Uchitel'
I A
IA
Shirokova
T E
TE
Gupalo
E M
EM
Gabrusenko
S A
SA
Naumov
V G
VG
D001792:Blood Platelets / Q000378:metabolism; D002311:Cardiomyopathy, Dilated / Q000097:blood* / Q000150:complications; D018450:Disease Progression; D005260:Female; D006487:Hemostasis / Q000502:physiology*; D020141:Hemostatic Disorders / Q000097:blood* / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation; D012307:Risk Factors