title: [Differential expression of guanylin in colorectal cancer].
abstract: OBJECTIVE
  To investigate the expression of guanylin in colorectal cancer.
  
  
  METHODS
  The expression of guanylin was examined by RT-PCR and semiquantitative analysis in 20 cases of colorectal cancer, and its relationship with clinical characteristics was analyzed.
  
  
  RESULTS
  The positive expression of guanylin in normal tissue (80%, 16/20) was significantly higher than that in tumor tissue (35%, 7/20) (P<0.01). The same result was found in the semiquantitative analysis of 14 cases with differential expression. Differential expression of guanylin in colorectal cancer was associate with TNM stage (P<0.05), not with sex, Borrmann type and degree of differentiation (all P>0.05).
  
  
  CONCLUSIONS
  There is differential expression of guanylin in colorectal cancer, and this kind of differential expression is associated with tumor TNM stage.
authors.affiliation: Department of Colorectal Oncology, Zhejiang Cancer Hospital, Hangzhou, China.
authors.forename: Yin-bo
authors.initials: YB
authors.lastname: Chen
authors.forename: Yu-ping
authors.initials: YP
authors.lastname: Zhu
authors.forename: Hai-yang
authors.initials: HY
authors.lastname: Feng
authors.forename: Yong
authors.initials: Y
authors.lastname: Liu
authors.forename: Jun
authors.initials: J
authors.lastname: Qian
authors.forename: Yong-tian
authors.initials: YT
authors.lastname: Fan
authors.forename: De-chuan
authors.initials: DC
authors.lastname: Li
mesh_terms: D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D005768:Gastrointestinal Hormones / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D045265:Natriuretic Peptides / Q000378:metabolism*; D009367:Neoplasm Staging
chemical_list: D005768:Gastrointestinal Hormones; D045265:Natriuretic Peptides; C072685:guanylin