title: Three-dimensional bioluminescence tomography based on Bayesian approach.
abstract: Bioluminescence tomography (BLT) poses a typical ill-posed inverse problem with a large number of unknowns and a relatively limited number of boundary measurements. It is indispensable to incorporate a priori information into the inverse problem formulation in order to obtain viable solutions. In the paper, Bayesian approach has been firstly suggested to incorporate multiple types of a priori information for BLT reconstruction. Meanwhile, a generalized adaptive Gaussian Markov random field (GAGMRF) prior model for unknown source density estimation is developed to further reduce the ill-posedness of BLT on the basis of finite element analysis. Then the distribution of bioluminescent source can be acquired by maximizing the log posterior probability with respect to a noise parameter and the unknown source density. Furthermore, the use of finite element method makes the algorithm appropriate for complex heterogeneous phantom. The algorithm was validated by numerical simulation of a 3-D micro-CT mouse atlas and physical phantom experiment. The reconstructed results suggest that we are able to achieve high computational efficiency and accurate localization of bioluminescent source.
authors.affiliation: The College of Electronic Information & Control Engineering, Beijing University of Technology, Beijing 100190, China.
authors.forename: Jinchao
authors.initials: J
authors.lastname: Feng
authors.forename: Kebin
authors.initials: K
authors.lastname: Jia
authors.forename: Chenghu
authors.initials: C
authors.lastname: Qin
authors.forename: Guorui
authors.initials: G
authors.lastname: Yan
authors.forename: Shouping
authors.initials: S
authors.lastname: Zhu
authors.forename: Xing
authors.initials: X
authors.lastname: Zhang
authors.forename: Junting
authors.initials: J
authors.lastname: Liu
authors.forename: Jie
authors.initials: J
authors.lastname: Tian
mesh_terms: D000465:Algorithms; D000818:Animals; D001499:Bayes Theorem; D008163:Luminescent Measurements / Q000379:methods*; D051379:Mice; D008807:Mice, Inbred BALB C; D019047:Phantoms, Imaging; D017785:Photons; D014057:Tomography, X-Ray Computed / Q000379:methods*