title: Silica xerogel/aerogel-supported lipid bilayers: consequences of surface corrugation.
abstract: The objective of this paper was to review our recent investigations of silica xerogel and aerogel-supported lipid bilayers. These systems provide a format to observe relationships between substrate curvature and supported lipid bilayer formation, lipid dynamics, and lipid mixtures phase behavior and partitioning. Sensitive surface techniques such as quartz crystal microbalance and atomic force microscopy are readily applied to these systems. To inform current and future investigations, we review the experimental literature involving the impact of curvature on lipid dynamics, lipid and phase-separated lipid domain localization, and membrane-substrate conformations and we review our molecular dynamics simulations of supported lipid bilayers with the atomistic and molecular information they provide.
authors.affiliation: Department of Chemical Engineering & Materials Science, University of California, Davis, CA 95616, USA.
authors.forename: Emel I
authors.initials: EI
authors.lastname: Goksu
authors.forename: Matthew I
authors.initials: MI
authors.lastname: Hoopes
authors.forename: Barbara A
authors.initials: BA
authors.lastname: Nellis
authors.forename: Chenyue
authors.initials: C
authors.lastname: Xing
authors.forename: Roland
authors.initials: R
authors.lastname: Faller
authors.forename: Curtis W
authors.initials: CW
authors.lastname: Frank
authors.forename: Subhash H
authors.initials: SH
authors.lastname: Risbud
authors.forename: Joe H
authors.initials: JH
authors.lastname: Satcher
authors.forename: Marjorie L
authors.initials: ML
authors.lastname: Longo
mesh_terms: D005782:Gels / Q000737:chemistry*; D008051:Lipid Bilayers / Q000737:chemistry*; D008560:Membrane Fluidity; D021962:Membrane Microdomains / Q000737:chemistry / Q000648:ultrastructure; D018625:Microscopy, Atomic Force; D008855:Microscopy, Electron, Scanning; D008958:Models, Molecular; D056004:Molecular Dynamics Simulation; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D005782:Gels; D008051:Lipid Bilayers; D012822:Silicon Dioxide