title: Increased propensity for central apnea in patients with obstructive sleep apnea: effect of nasal continuous positive airway pressure.
abstract: BACKGROUND
  There is increasing evidence of increased ventilatory instability in patients with obstructive sleep apnea (OSA), but previous investigations have not studied whether the hypocapnic apneic threshold is altered in this group.
  
  
  OBJECTIVE
  To compare the apneic threshold, CO2 reserve, and controller gain between subjects with and without OSA matched for age, sex, and body mass index.
  
  
  METHODS
  Hypocapnia was induced via nasal mechanical ventilation for 3 minutes. Cessation of mechanical ventilation resulted in hypocapnic central hypopnea or apnea depending upon the magnitude of the hypocapnia. The apnea threshold (Pet(CO2)-AT) was defined as the measured Pet(CO2) at which the apnea closest to the last hypopnea occurred. The CO2 reserve was defined as the change in Pet(CO2) between eupneic Pet(CO2) and Pet(CO2)-AT. Controller gain was defined as the ratio of change in Ve between control and hypopnea or apnea to the DeltaPet(CO2).
  
  
  RESULTS
  Eleven pairs of subjects were studied. There was no difference in the Pet(CO2)-AT between the two groups. However, the CO2 reserve was smaller in the subjects with OSA (2.2 +/- 0.6 mm Hg) compared with the control subjects (4.5 +/- 1.4 mm Hg; P < 0.001). The controller gain was increased in the subjects with OSA (3.7 +/- 1.3 L/min/mm Hg) compared with the control subjects (1.6 +/- 0.5 L/min/mm Hg; P < 0.001). Controller gain decreased and CO2 reserve increased in seven subjects restudied after using continuous positive airway pressure for 1 month.
  
  
  CONCLUSIONS
  Ventilatory instability is increased in subjects with OSA and is reversible with the use of continuous positive airway pressure.
authors.affiliation: Wayne State University School of Medicine, Division of Pulmonary, Allergy, Critical Care & Sleep, Harper University Hospital, 3 Hudson 3990 John R, Detroit, MI 48201, USA.
authors.forename: Anan
authors.initials: A
authors.lastname: Salloum
authors.forename: James A
authors.initials: JA
authors.lastname: Rowley
authors.forename: Jason H
authors.initials: JH
authors.lastname: Mateika
authors.forename: Susmita
authors.initials: S
authors.lastname: Chowdhuri
authors.forename: Qasim
authors.initials: Q
authors.lastname: Omran
authors.forename: M Safwan
authors.initials: MS
authors.lastname: Badr
mesh_terms: D000328:Adult; D002245:Carbon Dioxide / Q000097:blood*; D002628:Chemoreceptor Cells / Q000502:physiology; D045422:Continuous Positive Airway Pressure; D005260:Female; D006801:Humans; D016857:Hypocapnia / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D012018:Reflex / Q000502:physiology; D015656:Respiratory Mechanics / Q000502:physiology; D012684:Sensory Thresholds / Q000502:physiology; D020182:Sleep Apnea, Central / Q000097:blood / Q000503:physiopathology*; D020181:Sleep Apnea, Obstructive / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy*; D012894:Sleep Stages / Q000502:physiology
chemical_list: D002245:Carbon Dioxide