title: Microwave assisted tandem reactions for the synthesis of 2-hydrazolyl-4-thiazolidinones.
abstract: A tandem method for the synthesis of 2-hydrazolyl-4-thiazolidinones (5) from commercially available materials in a 3 component reaction has been developed. The reaction connects aldehydes, thiosemicarbazides and maleic anhydride, effectively assisted by microwave irradiation. The synthesis of a new type of compound, 2-hydrazolyl-5,5-diphenyl-4-thiazolidinone (7), obtained by treatment of thiosemicarbazone with benzil in basic media is also reported. HOMO/LUMO energies, orbital coefficients and charge distribution were used to explain the proposed reaction mechanism.
authors.affiliation: Laboratorio de Química Farmacéutica, DQO, Facultad de Química, Universidad de la República, Gral Flores 2124, CC 1157, Montevideo Uruguay.
authors.forename: Cecilia
authors.initials: C
authors.lastname: Saiz
authors.forename: Chiara
authors.initials: C
authors.lastname: Pizzo
authors.forename: Eduardo
authors.initials: E
authors.lastname: Manta
authors.forename: Peter
authors.initials: P
authors.lastname: Wipf
authors.forename: S Graciela
authors.initials: SG
authors.lastname: Mahler