title: Green tea consumption and the risk of liver cancer in Japan: the Ohsaki Cohort study.
abstract: OBJECTIVE
  To investigate the association between green tea consumption and liver cancer incidence.
  
  
  METHODS
  We prospectively followed 41,761 Japanese adults aged 40-79 years, without a history of cancer at the baseline or any missing data for green tea consumption frequency. Cox proportional hazards models were used to calculate hazard ratios (HR) with 95% confidence intervals (CI), adjusted for age, alcohol drinking, smoking, the consumption of coffee, vegetables, dairy products, fruit, fish, and soybean.
  
  
  RESULTS
  Over 9 years of follow-up, among 325,947 accrued person-years, the total incidence of liver cancer was 247 cases. We found that green tea consumption was inversely associated with the incidence of liver cancer. In men, the multivariate-adjusted HRs (95% CIs) for liver cancer incidence with different green tea consumption categories were 1.00 (reference) for <1 cup/day, 0.83 (0.53-1.30) for 1-2 cups/day, 1.11 (0.73-1.68) for 3-4 cups/day, and 0.63 (0.41-0.98) for >/=5 cups/day (p for trend = 0.11). The corresponding data among women were 1.00 (reference), 0.68 (0.35-1.31), 0.79 (0.44-1.44), 0.50 (0.27-0.90) (p for trend = 0.04).
  
  
  CONCLUSIONS
  Green tea consumption is associated with a reduced risk of liver cancer incidence.
authors.affiliation: Division of Epidemiology, Department of Public Health and Forensic Medicine, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan. a5mb1008-thk@umin.ac.jp
authors.forename: Akane
authors.initials: A
authors.lastname: Ui
authors.forename: Shinichi
authors.initials: S
authors.lastname: Kuriyama
authors.forename: Masako
authors.initials: M
authors.lastname: Kakizaki
authors.forename: Toshimasa
authors.initials: T
authors.lastname: Sone
authors.forename: Naoki
authors.initials: N
authors.lastname: Nakaya
authors.forename: Kaori
authors.initials: K
authors.lastname: Ohmori-Matsuda
authors.forename: Atsushi
authors.initials: A
authors.lastname: Hozawa
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Nishino
authors.forename: Ichiro
authors.initials: I
authors.lastname: Tsuji
mesh_terms: D000328:Adult; D000368:Aged; D001628:Beverages; D002277:Carcinoma / Q000453:epidemiology / Q000209:etiology*; D015331:Cohort Studies; D004327:Drinking Behavior / Q000502:physiology*; D004435:Eating / Q000502:physiology; D005260:Female; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D008113:Liver Neoplasms / Q000453:epidemiology / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D009749:Nutrition Surveys; D012307:Risk Factors; D013662:Tea
chemical_list: D013662:Tea