title: Pathology, pathogenesis and therapy of growth hormone (GH)-producing pituitary adenomas: technical advances in histochemistry and their contribution.
abstract: Growth hormone (GH)-producing adenomas (GHomas) are one of the most frequently-occurring pituitary adenomas. Differentiation of hormone-producing cells in the pituitary gland is regulated by transcription factors and co-factors. The transcription factors include Pit-1, Prop-1, NeuroD1, Tpit, GATA-2, SF-1. Aberrant expression of transcription factors such as Pit-1 results in translineage expression of GH in adrenocorticotropic hormone-producing adenomas (ACTHomas). This situation has been substantiated by GFP-Pit-1 transfection expression in the AtT20 cell line. Experimentally, GHomas have been induced in GH-releasing hormone (GHRH) or Prop-1 transgenic animals. Immunohistochemical detection of somatostatin receptor (SSTR2a) has recently emphasized their role in the response of GHomas to somatostatin analogue therapy. In this review, the advances in technology and their contribution to cell biology and medical practice are discussed.
authors.affiliation: Department of Pathology, Tokai University School of Medicine, 143 Shimokasuya, Isehara-city, Kanagawa 259-1193, Japan. osamura@is.icc.u-tokai.ac.jp
authors.forename: Robert Y
authors.initials: RY
authors.lastname: Osamura
authors.forename: Noboru
authors.initials: N
authors.lastname: Egashira
authors.forename: Hanako
authors.initials: H
authors.lastname: Kajiya
authors.forename: Mao
authors.initials: M
authors.lastname: Takei
authors.forename: Maya
authors.initials: M
authors.lastname: Tobita
authors.forename: Takashi
authors.initials: T
authors.lastname: Miyakoshi
authors.forename: Chie
authors.initials: C
authors.lastname: Inomoto
authors.forename: Susumu
authors.initials: S
authors.lastname: Takekoshi
authors.forename: Akira
authors.initials: A
authors.lastname: Teramoto