A 32-year-old woman with chest pain, hematemesis, and thrombocytopenia.
The diagnosis of TTP should be considered in any clinical scenario in which hemolysis and thrombocytopenia are present. If other secondary causes are ruled out, therapy should instituted as rapidly as possible. TPE remains the standard of care for TTP. In emergent situations where TPE is not immediately available, infusion of FFP at 15 mL/kg per day and initiation of glucocorticoids is acceptable.
Boulmay
Brian C
BC
Division of Hematology, Louisiana State University Health Sciences Center, New Orleans, USA.
Fitzgerald
Robert
R
Lewis
Brian
B
D000328:Adult; D001241:Aspirin / Q000627:therapeutic use; D002637:Chest Pain / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006396:Hematemesis / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D006801:Humans; D008775:Methylprednisolone / Q000627:therapeutic use; D010951:Plasma Exchange; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D011697:Purpura, Thrombotic Thrombocytopenic / Q000150:complications* / Q000175:diagnosis / Q000628:therapy
D005938:Glucocorticoids; D010975:Platelet Aggregation Inhibitors; D001241:Aspirin; D008775:Methylprednisolone