[Cystatin C and adiponectin in diabetics with and without coronary artery disease].
BACKGROUND
Patients with type 2 diabetes have a high incidence of coronary artery disease, which is even higher among those with renal failure. A serum level of cystatin C are used to assess renal function and is a potential cardiovascular risk factor. Adiponectin is an anti-atherogenic factor.


OBJECTIVE
To measure cystatin C and adiponectin in type 2 diabetic patients with and without coronary artery disease.


METHODS
Nine diabetic patients with coronary artery disease aged 76+/- 10 years, 20 diabetics without coronary artery disease aged 61 +/-5 years and 20 non diabetic subjects aged 57+/-10 years, were studied.


RESULTS
Serum levels of cystatin C (mg/L) were 1.5 (range 0.89-219), 0.81 (range 0.71-1.08) and 0.68 mg/L (range 055-0.75) in diabetics with and without coronary artery disease and controls, respectively (p <0.0001). No differences in adiponectin between groups and no association between cystatin C and adiponectin, were observed. No association between both parameters and body mass index orglycosilated hemoglobin Ale was observed. Cystatin C had a positive correlation with serum creatinine (r =0.57 p <0.001).


CONCLUSIONS
Diabetics with coronary artery disease have higher levels of cystatin C, that are closely correlated with serum creatinine levels.
Wolff
Carlos
C
Laboratorio de Investigaciones Clínicas, Departamento de Medicina Occidente, Facultad de Medicina, Universidad de Chile, Santiago, Chile. cwfl255@yahoo.es
Durruty
Pilar
P
Espinoza
Jaime
J
Ripamonti
Soledad
S
Díaz
Jaime
J
D052242:Adiponectin / Q000097:blood*; D000368:Aged; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000097:blood* / Q000209:etiology; D055316:Cystatin C / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D003925:Diabetic Angiopathies / Q000097:blood*; D006801:Humans; D008875:Middle Aged; D012307:Risk Factors
D052242:Adiponectin; D015415:Biomarkers; D055316:Cystatin C