title: FOXP1 status in splenic marginal zone lymphoma: a fluorescence in situ hybridization and immunohistochemistry approach.
abstract: Splenic marginal zone lymphoma (SMZL) is a well-recognized entity in which chromosomal aberrations seem to be potential markers in diagnosis, prognosis and disease monitoring. FOXP1 is a transcriptional regulator of B lymphopoiesis that is deregulated in some types of NHL. Translocation t(3;14)(p14;q32) has been described in marginal zone lymphomas but few series have studied FOXP1 involvement in SMZL. We performed cytogenetic, fluorescence in situ hybridization (FISH) and immunohistochemical (IHC) studies in a series of 36 patients in order to study the status of FOXP1 in this entity. According to our results, FOXP1 is not rearranged in SMZL, although we were able to demonstrate gains of FOXP1 gene due to trisomy 3/3p by FISH. FOXP1 protein expression seemed to be not related to any aberration and IHC studies are not conclusive.
authors.affiliation: Dept. Biologia Animal, Vegetal i Ecologia. Unitat d'Antropologia Biològica. Facultat de Biociències. Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain.
authors.forename: Cristina
authors.initials: C
authors.lastname: Baró
authors.forename: Blanca
authors.initials: B
authors.lastname: Espinet
authors.forename: Marta
authors.initials: M
authors.lastname: Salido
authors.forename: Lluís
authors.initials: L
authors.lastname: Colomo
authors.forename: Elisa
authors.initials: E
authors.lastname: Luño
authors.forename: Lourdes
authors.initials: L
authors.lastname: Florensa
authors.forename: Ana
authors.initials: A
authors.lastname: Ferrer
authors.forename: Antonio
authors.initials: A
authors.lastname: Salar
authors.forename: Elias
authors.initials: E
authors.lastname: Campo
authors.forename: Sergi
authors.initials: S
authors.lastname: Serrano
authors.forename: Francesc
authors.initials: F
authors.lastname: Solé
mesh_terms: D051858:Forkhead Transcription Factors / Q000096:biosynthesis / Q000235:genetics*; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D018442:Lymphoma, B-Cell, Marginal Zone / Q000235:genetics* / Q000378:metabolism; D012097:Repressor Proteins / Q000096:biosynthesis / Q000235:genetics*; D013160:Splenic Neoplasms / Q000235:genetics* / Q000378:metabolism
chemical_list: C486626:FOXP1 protein, human; D051858:Forkhead Transcription Factors; D012097:Repressor Proteins