[Ligans from branch of Hypericum petiolulatum].
OBJECTIVE
To investigate the chemical constituents of Hypericum petiolulatum.


METHODS
The chemical constituents were isolated and purified by column chromatography on silica gel, macroporous adsorbent resin, Sephadex LH-20, and preparative HPLC. Structures of the compounds were identified by NMR and MS spectroscopic methods.


RESULTS
Nine lignans were obtained and their structures were elucidated as (-)-(2R, 3R)-1-O-feruloyl-8,8'-bisdihydrosiringenin (1), (-) -secoisolariciresinol 4-O-beta-D-glucopyrano-side (2), isolariciresinol-beta-4'-O-beta-D-glucopyranoside (3), 5-methoxy-9beta-xylopyra-nosyl-(+) -isolariciresinol (4), (+) -lyoniresinol 2alpha-O-beta-D-xylopyranoside (5), 5-methoxy-9-beta-xylopyranosyl-(-) -isolariciresinol (6), isolariciresinol 6a-O-beta-D-gluco-side (7), (+)-lyoniresinol 3alpha-O-beta-D-xylopyranoside (8) and 7-methoxy-5-benzofuranpropanol 4'-O-beta-D-glucopyranoside (9).


CONCLUSIONS
Coupound 1 was new and compounds 2-9 were obtained from the genus Hypericum for the first time.
Zhao
Qi
Q
Department of Pharmacy, People's Hospital of Daqing City, Daqing 163316, China.
Liu
Juan
J
Wang
Funan
F
Liu
Guifan
G
Wang
Guizhi
G
Zhang
Kun
K
D004365:Drugs, Chinese Herbal / Q000737:chemistry; D020902:Hypericum / Q000737:chemistry*; D017705:Lignans / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry
D004365:Drugs, Chinese Herbal; D017705:Lignans