NSF after Gadovist exposure: a case report and hypothesis of NSF development.
So far no cases of nephrogenic systemic fibrosis (NSF) have been published on macrocyclical gadolinium-based contrast media (Gd-CM), assumed as low NSF risk CM due to their complex stability. In our haemodialysis-dependent patient, the first symptoms indicating NSF appeared about 16 months after the exposure to Gadovist, a macrocyclical Gd-CM, and 1 month after x-ray angiography with iodinated CM (Ultravist). This indicates that in addition to excretory renal failure and Gd-CM exposure, the loss of biosynthetic renal function could be essential for NSF development. A hypothesis of possible pathways involved in the development of NSF is presented.
Wollanka
Helmut
H
SRH Hospital Karlsbad-Langensteinbach Ltd, Centre for Neurology and Early Rehabilitation, Academic Hospital at Heidelberg University, Heidelberg, Germany.
Weidenmaier
Werner
W
Giersig
Cecylia
C
D000368:Aged; D003287:Contrast Media / Q000009:adverse effects*; D006801:Humans; D008297:Male; D054989:Nephrogenic Fibrosing Dermopathy / Q000139:chemically induced*; D009942:Organometallic Compounds / Q000009:adverse effects*
D003287:Contrast Media; D009942:Organometallic Compounds; C090600:gadobutrol