title: A novel function of lipid droplets in regulating longevity.
abstract: Growing evidence supports the view that LDs (lipid droplets) are dynamic organelles that can serve both as an intracellular signalling compartment and as an organizing platform orchestrating many vital processes in eukaryotic cells. It has become clear that the LDs-confined deposition and lipolytic degradation of neutral lipids define longevity in multicellular eukaryotic organisms and yeast. We summarize the evidence in support of the essential role that LDs play in longevity regulation and propose several molecular mechanisms by which these dynamic organellar compartments control the aging process in multicellular eukaryotes and yeast.
authors.affiliation: Department of Biology, Concordia University, 7141 Sherbrooke Street, West, SP Building, Room 501-9, Montreal, QC, Canada.
authors.forename: Alexander A
authors.initials: AA
authors.lastname: Goldberg
authors.forename: Simon D
authors.initials: SD
authors.lastname: Bourque
authors.forename: Pavlo
authors.initials: P
authors.lastname: Kyryakov
authors.forename: Tatiana
authors.initials: T
authors.lastname: Boukh-Viner
authors.forename: Christopher
authors.initials: C
authors.lastname: Gregg
authors.forename: Adam
authors.initials: A
authors.lastname: Beach
authors.forename: Michelle T
authors.initials: MT
authors.lastname: Burstein
authors.forename: Gayane
authors.initials: G
authors.lastname: Machkalyan
authors.forename: Vincent
authors.initials: V
authors.lastname: Richard
authors.forename: Sonia
authors.initials: S
authors.lastname: Rampersad
authors.forename: Vladimir I
authors.initials: VI
authors.lastname: Titorenko
mesh_terms: D000375:Aging / Q000502:physiology; D000818:Animals; D005057:Eukaryotic Cells / Q000378:metabolism; D050356:Lipid Metabolism; D015388:Organelles / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology