A case of discordant HbA(1c): a method-dependent error.
Although glycated haemoglobin (HbA(1c)) has become the key biochemical marker of long-term glycaemic control, analytical method-dependent differences in results can occur when haemoglobin variants are present or HbA(1c) is reduced by decreased red cell survival. When the measured HbA(1c) level is discordant with the patient's blood glucose measurements and clinical status, fructosamine is an alternative biochemical marker that can provide a more accurate estimate of the glycaemic control and enable clinicians to appropriately manage patients.
Dimeski
Goce
G
Pathology Queensland, Brisbane, QLD, Australia. goce_dimeski@health.qld.gov.au
Pretorius
Carel J
CJ
Russell
Anthony W
AW
Miller
Stephen P
SP
Bird
Robert J
RJ
Ungerer
Jacobus P J
JP
D000368:Aged; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D015190:Blood Glucose Self-Monitoring; D002852:Chromatography, Ion Exchange / Q000379:methods*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D019270:Fructosamine / Q000097:blood; D006442:Glycated Hemoglobin / Q000032:analysis*; D006455:Hemoglobins, Abnormal / Q000032:analysis; D006801:Humans; D007118:Immunoassay; D008297:Male
D015415:Biomarkers; D001786:Blood Glucose; D019270:Fructosamine; D006442:Glycated Hemoglobin; D006455:Hemoglobins, Abnormal; C517652:hemoglobin A1c protein, human; C060131:hemoglobin Athens-Georgia