The hepatoprotective and antifibrotic effects of Saururus chinensis against carbon tetrachloride induced hepatic fibrosis in rats.
BACKGROUND
Saururus chinensis (Lour.) Baill (Saururaceae) has been used in Chinese folk medicine for treatment of various diseases, such as edema, jaundice, gonorrhea, antipyretic, diuretic, and antiinflammatory agents.


OBJECTIVE
Our aim was to evaluate the hepatoprotective and antifibrotic effects of Saururus chinensis extract (SC-E) in carbon tetrachloride (CCl(4)) induced liver fibrosis rats.


METHODS
The SC-E (70 mg/kg) was administrated via gavage once a day starting from the onset of CCl(4) treatment (14 weeks) for subsequent 8 weeks. Evaluated with liver index, serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), hyaluronic acid (HA), hepatic malondialdehyde (MDA) content, and superoxide dismutase (SOD) activity, total cholesterol (TC), triglyceride (TG), total lipoprotein (TP), albumin (ALB), hydroxyproline (HYP), total antioxidant capacity (T-AOC), laminin (LN), type III collagen terminal peptide (PC-IIINP), and type IV collagen (IV-C), as well as with histopathologic changes of liver.


RESULTS
SC-E effectively reduced the elevated levels of liver index, serum ALT, AST, HA, and hepatic MDA contents, enhance the reduced hepatic SOD activity in CCl(4)-treated rats. The histopathological analysis suggested that SC-E obviously alleviated the degree of liver fibrosis induced by CCl(4).


CONCLUSIONS
Those results suggest SC-E has protective and therapeutic effects on liver fibrosis induced by CCl(4).
Wang
Lishu
L
Jilin Provincial Academy of Chinese Medicine Sciences, Changchun 130021, China.
Cheng
Dongyan
D
Wang
Haisheng
H
Di
Lin
L
Zhou
Xuefeng
X
Xu
Tunhai
T
Yang
Xianwen
X
Liu
Yonghong
Y
D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity*; D004195:Disease Models, Animal; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D008103:Liver Cirrhosis / Q000097:blood / Q000139:chemically induced / Q000201:enzymology / Q000473:pathology / Q000517:prevention & control*; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D032134:Saururaceae / Q000737:chemistry*
D010936:Plant Extracts; D002251:Carbon Tetrachloride