Simultaneous alignment of short reads against multiple genomes.
Genome resequencing with short reads generally relies on alignments against a single reference. GenomeMapper supports simultaneous mapping of short reads against multiple genomes by integrating related genomes (e.g., individuals of the same species) into a single graph structure. It constitutes the first approach for handling multiple references and introduces representations for alignments against complex structures. Demonstrated benefits include access to polymorphisms that cannot be identified by alignments against the reference alone. Download GenomeMapper at http://1001genomes.org.
Schneeberger
Korbinian
K
Department of Molecular Biology, Max Planck Institute for Developmental Biology, Spemannstrasse 37-39, D-72076 Tübingen, Germany. korbinian.schneeberger@tuebingen.mpg.de
Hagmann
Jörg
J
Ossowski
Stephan
S
Warthmann
Norman
N
Gesing
Sandra
S
Kohlbacher
Oliver
O
Weigel
Detlef
D
D000465:Algorithms; D001483:Base Sequence; D019295:Computational Biology / Q000379:methods; D016678:Genome / Q000235:genetics; D023281:Genomics / Q000379:methods; D008969:Molecular Sequence Data; D015203:Reproducibility of Results; D016415:Sequence Alignment / Q000379:methods*; D017422:Sequence Analysis, DNA / Q000379:methods*; D012689:Sequence Homology, Nucleic Acid; D012984:Software