Modeling spatial and temporal dynamics of chemotactic networks.
When stimulated by chemoattractants, eukaryotic cells respond through a combination of temporal and spatial dynamics. These responses come about because of the interaction of a large number of signaling components. The complexity of these systems makes it hard to understand without a means of systematically generating and testing hypotheses. Computer simulations have proved to be useful in testing conceptual models. Here we outline the steps required to develop these models.
Yang
Liu
L
Department of Electrical and Computer Engineering, The Johns Hopkins University, Baltimore, MD, USA.
Iglesias
Pablo A
PA
D002633:Chemotaxis / Q000502:physiology*; D008962:Models, Theoretical; D015398:Signal Transduction