Increased aldosterone among HIV-infected women with visceral fat accumulation.
Increased aldosterone has been associated with obesity and the metabolic syndrome in non-HIV-infected individuals, but aldosterone has not been investigated among HIV-infected patients with increased visceral adipose tissue (VAT). Twenty-four-hour urine aldosterone was assessed among age and BMI-matched HIV-infected women with increased VAT, HIV-infected women without increased VAT and healthy controls. Twenty-four hour urine aldosterone was higher in HIV-infected women with increased VAT and was associated with SBP, VAT and hemoglobin A1c. Increased aldosterone may contribute to the detrimental effects of excess visceral adiposity on blood pressure and glucose homeostasis among HIV patients.
Lo
Janet
J
Program in Nutritional Metabolism, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Looby
Sara E D
SE
Wei
Jeffrey
J
Adler
Gail K
GK
Grinspoon
Steven K
SK
D000328:Adult; D000450:Aldosterone / Q000652:urine*; D015415:Biomarkers / Q000652:urine; D015992:Body Mass Index; D016022:Case-Control Studies; D005260:Female; D015658:HIV Infections / Q000652:urine*; D006801:Humans; D050152:Intra-Abdominal Fat / Q000378:metabolism*
D015415:Biomarkers; D000450:Aldosterone