title: Investigating agenesis of the corpus callosum using functional MRI: a study examining interhemispheric coordination of motor control.
abstract: We report fMRI findings in 3 asymptomatic cases of agenesis of the corpus callosum, the largest white matter bundle in the brain, which is responsible for interhemispheric transfer of information. Sensory information was presented to 1 hemisphere, and the patients had to generate a motor response governed by the contralateral hemisphere. Enhanced ipsilateral motor pathways have been suggested as a compensation method for people with agenesis of the corpus callosums; our functional magnetic resonance imaging data did not support this theory.
authors.affiliation: Department of Diagnostic Imaging, The Ottawa Hospital, University of Ottawa, Ottawa, Canada. chlum@Ottawahospital.on.ca
authors.forename: Cheemun
authors.initials: C
authors.lastname: Lum
authors.forename: Mary Pat
authors.initials: MP
authors.lastname: McAndrews
authors.forename: Andrei I
authors.initials: AI
authors.lastname: Holodny
authors.forename: Kathleen A
authors.initials: KA
authors.lastname: McManus
authors.forename: Adrian
authors.initials: A
authors.lastname: Crawley
authors.forename: Santanu
authors.initials: S
authors.lastname: Chakraborty
authors.forename: David J
authors.initials: DJ
authors.lastname: Mikulis
mesh_terms: D000328:Adult; D058540:Aicardi Syndrome / Q000503:physiopathology*; D001921:Brain / Q000503:physiopathology*; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D009048:Motor Skills / Q000502:physiology*; D009483:Neuropsychological Tests