title: Chemical synthesis of nucleoside H-boranophosphonates and their application as precursors of P-modified nucleotide analogues.
abstract: Nucleoside H-boranophosphonates were synthesized via the condensation reactions of appropriately protected nucleosides with monopyridinium H-boranophosphonate and subsequent deprotection under basic conditions. 3',5'-O-Protected dinucleoside H-boranophosphonates were also synthesized via the condensation of the corresponding 5'-O-protected nucleoside 3'-H-boranophosphonates with 3'-O-protected nucleosides. A study on the chemical properties of the resultant dinucleoside phosphate analogues revealed that the P-H group could be further modified under anhydrous basic conditions.
authors.affiliation: Department of Chemistry, Faculty of Engineering, Gifu University, Gifu 501-1193, Japan. oka@gifu-u.ac.jp
authors.forename: Natsuhisa
authors.initials: N
authors.lastname: Oka
authors.forename: Renpei
authors.initials: R
authors.lastname: Higashida
authors.forename: Yuji
authors.initials: Y
authors.lastname: Takayama
authors.forename: Kaori
authors.initials: K
authors.lastname: Ando
authors.forename: Takeshi
authors.initials: T
authors.lastname: Wada
mesh_terms: D001880:Boranes / Q000737:chemistry*; D009711:Nucleotides / Q000138:chemical synthesis / Q000737:chemistry*; D063065:Organophosphonates / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D001880:Boranes; D009711:Nucleotides; D063065:Organophosphonates