[Studies on the effects of Qi-boosting toxin-resolving decoction on proliferation of nasopharyngeal carcinoma cell].
OBJECTIVE
To investigate the effect of several traditional Chinese medicine formula therapies on proliferation of nasopharyngeal carcinoma cell line HNE1.


METHODS
The inhibition effect of medicine serums of Qi-Boosting Toxin-Resolving granule on proliferation of NPC cell line HNE1 in vitro was observed by MTT assay.


RESULTS
The rates of survival cells in Qi-Boosting Toxin-Resolving decoction group and Toxin-Resolving group were the lowest after 48 hours treatment, while Qi-Boosting group, yin-nourishing group, residual-component group medicine serums had the most obvious effects on the rates of survival cells at 72 hours. The inhibition ratio of 15% Qi-Boosting Toxin-Resolving granule medicine serums was 67.68%.


CONCLUSIONS
The result of MTT assay showed that cell proliferation was significantly inhibited by Qi-Boosting Toxin-Resolving granule and its separate composes medicine serums. Qi-Boosting Toxin-Resolving granule had the most significantly specific effects. The effects were correlated with serum concentration and treatment time of Qi-Boosting Toxin-Resolving granule and its separate composes medicine.
Hu
Binya
B
Department of Otolaryngology, Hunan Children's Hospital, Changsha, 410007, China. zhizi628@126.com
Tian
Daofa
D
He
Yingchun
Y
D000818:Animals; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006801:Humans; D008516:Medicine, Chinese Traditional; D009303:Nasopharyngeal Neoplasms; D051381:Rats; D017207:Rats, Sprague-Dawley; D044967:Serum
D004365:Drugs, Chinese Herbal