title: Individual and combined effect of meso-2,3-dimercaptosuccinic acid and allicin on blood and tissue lead content in mice.
abstract: It has been shown that garlic and its main bioactive component, allicin, as natural chelating agents can reduce blood and tissue lead content in animal models. In this study the effect of allicin, alone or combined with meso-2,3-dimercaptosuccinic acid (DMSA), in decreasing lead content of blood and tissues of mice was evaluated. Swiss albino mice were exposed to 1000 ppm of lead in water for 35 days and then placed in various treatment groups including groups administered oral allicin, DMSA, or their combination. The concentrations of lead in blood, kidney, liver, bone and brain were measured using atomic absorption spectrophotometry. Both, allicin and DMSA decreased the blood and tissue lead concentration. There was an additive effect of the combined administration of allicin and DMSA in reducing bone lead. No side effect was observed in all treated groups. Combined use of DMSA and allicin seems to be a better choice in the treatment of chronic lead intoxication.
authors.affiliation: Department of Clinical Sciences, School of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran. mraslani@um.ac.ir
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Aslani
authors.forename: Vahid
authors.initials: V
authors.lastname: Najarnezhad
authors.forename: Mehrdad
authors.initials: M
authors.lastname: Mohri
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000187:drug effects* / Q000378:metabolism; D002614:Chelating Agents / Q000494:pharmacology / Q000627:therapeutic use*; D004220:Disulfides; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005260:Female; D005737:Garlic / Q000737:chemistry*; D007854:Lead / Q000097:blood / Q000378:metabolism*; D007855:Lead Poisoning / Q000188:drug therapy*; D051379:Mice; D008517:Phytotherapy; D004113:Succimer / Q000494:pharmacology / Q000627:therapeutic use*; D013441:Sulfinic Acids / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D002614:Chelating Agents; D004220:Disulfides; D013441:Sulfinic Acids; D007854:Lead; C006452:allicin; D004113:Succimer