title: Identification of antiadipogenic constituents of the rhizomes of Anemarrhena asphodeloides.
abstract: Three new phenolic compounds, (E)-4'-demethyl-6-methyleucomin (1), anemarcoumarin A (2), and anemarchalconyn (3), were isolated from an ethyl acetate extract of the rhizomes of Anemarrhena asphodeloides, together with seven known compounds (4-10). The structures of the new compounds (1-3) were determined on the basis of spectroscopic data interpretation. Compound 3 exhibited a potent inhibitory effect against the differentiation of preadipocyte 3T3-L1 cells with an IC50 value of 5.3 microM.
authors.affiliation: The Center for Cell Signaling & Drug Discovery Research, College of Pharmacy, Ewha Womans University, Seoul 120-750, Korea.
authors.forename: Ui Joung
authors.initials: UJ
authors.lastname: Youn
authors.forename: Ye Seul
authors.initials: YS
authors.lastname: Lee
authors.forename: Hana
authors.initials: H
authors.lastname: Jeong
authors.forename: Jun
authors.initials: J
authors.lastname: Lee
authors.forename: Joo-Won
authors.initials: JW
authors.lastname: Nam
authors.forename: Yoo Jin
authors.initials: YJ
authors.lastname: Lee
authors.forename: Eun Sook
authors.initials: ES
authors.lastname: Hwang
authors.forename: Je-Hyun
authors.initials: JH
authors.lastname: Lee
authors.forename: Dongho
authors.initials: D
authors.lastname: Lee
authors.forename: Sam Sik
authors.initials: SS
authors.lastname: Kang
authors.forename: Eun-Kyoung
authors.initials: EK
authors.lastname: Seo
mesh_terms: D041721:3T3-L1 Cells / Q000187:drug effects; D050156:Adipogenesis / Q000187:drug effects*; D031403:Anemarrhena / Q000737:chemistry*; D000818:Animals; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D007723:Korea; D051379:Mice; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D027343:Rhizome / Q000737:chemistry
chemical_list: C545133:(E)-4'-demethyl-6-methyleucomin; D003374:Coumarins; D010636:Phenols; C545134:anemarchalconyn; C545135:anemarcoumarin A