Occupational liver injury due to N,N-dimethylformamide in the synthetics industry.
N,N-dimethylformamide (DMF) is a solvent used extensively in the chemical industry. The main toxic effect reported after exposure to DMF is hepatotoxicity. We encountered four patients with liver injury due to DMF exposure; the severity of the liver injury was related to the exposure levels. After removal of exposure, all patients recovered without specific treatment. A careful evaluation of occupational history is necessary when liver dysfunction develops in industrial workers.
Hamada
Maho
M
Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, To-on, Japan.
Abe
Masanori
M
Tokumoto
Yoshio
Y
Miyake
Teruki
T
Murakami
Hidehiro
H
Hiasa
Yoichi
Y
Matsuura
Bunzo
B
Sato
Kohei
K
Onji
Morikazu
M
D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D002617:Chemical Industry; D056486:Chemical and Drug Induced Liver Injury / Q000201:enzymology / Q000209:etiology*; D004126:Dimethylformamide; D005559:Formamides / Q000633:toxicity*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000201:enzymology / Q000209:etiology*; D016273:Occupational Exposure; D012997:Solvents / Q000633:toxicity; D005723:gamma-Glutamyltransferase / Q000097:blood
D005559:Formamides; D012997:Solvents; D004126:Dimethylformamide; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase