Line up base pairs and intercalators one by one in a stable duplex.
A stable double helix involving alternating base pairs and azobenzene moieties was constructed. In this supramolecule, base pairs and azobenzenes are lined up one by one to form an interstrand-wedged motif: each base pair is sandwiched with two azobenzenes, and each azobenzene intercalates between two base pairs. This motif was formed by the hybridization of two modified DNA tethering multiple azobenzene moieties at a frequency of one azobenzene for every two nucleotides. Furthermore, this structure could be simply dismantled by UV light irradiation and reformed with the irradiation of visible light. By using this new duplex motif, construction of a variety of photoresponsive nanostructures and nanodevices is highly expected.
Liang
Xingguo
X
Department of Molecular Design and Engineering, Graduate School of Engineering, Nagoya University, Nagoya 464-8603, Japan.
Mochizuki
Toshio
T
Nishioka
Hidenori
H
Asanuma
Hiroyuki
H
D001391:Azo Compounds / Q000737:chemistry*; D020029:Base Pairing; D004247:DNA / Q000737:chemistry*; D007364:Intercalating Agents / Q000737:chemistry*; D008958:Models, Molecular; D014466:Ultraviolet Rays
D001391:Azo Compounds; D007364:Intercalating Agents; D004247:DNA; C009850:azobenzene