title: Synthesis and evaluation of 9-aminoacridines derived from benzyne click chemistry.
abstract: A small set of 9-aminoacridine-3- and 4-carboxamides were synthesized efficiently using the benzyne/azide click chemistry. The products bind to duplex DNA but have different antitumour activity in the HL60 cell line.
authors.affiliation: School of Pharmacy, University of East Anglia, Norwich NR4 7TJ, United Kingdom.
authors.forename: Lesley A
authors.initials: LA
authors.lastname: Howell
authors.forename: Aaron
authors.initials: A
authors.lastname: Howman
authors.forename: Maria A
authors.initials: MA
authors.lastname: O'Connell
authors.forename: Anja
authors.initials: A
authors.lastname: Mueller
authors.forename: Mark
authors.initials: M
authors.lastname: Searcey
mesh_terms: D000585:Aminacrine / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D001555:Benzene Derivatives / Q000737:chemistry*; D045744:Cell Line, Tumor; D004247:DNA / Q000737:chemistry; D004264:DNA Topoisomerases, Type I / Q000378:metabolism; D006801:Humans; D059004:Topoisomerase I Inhibitors
chemical_list: D000970:Antineoplastic Agents; D001555:Benzene Derivatives; D059004:Topoisomerase I Inhibitors; C524146:benzyne; D000585:Aminacrine; D004247:DNA; D004264:DNA Topoisomerases, Type I