title: Trends in pathogens colonising the respiratory tract of adult patients with cystic fibrosis, 1985-2005.
abstract: BACKGROUND
  The treatment of patients with CF has continued to evolve. We hypothesised that sputum microbiology may have changed as a result of this.
  
  
  METHODS
  Retrospective analysis of sputum microbiology from adult CF patients (1985 to 2005) using the Royal Brompton Hospital CF database.
  
  
  RESULTS
  Colonisation with Pseudomonas aeruginosa or Staphylococcus aureus between 1985 and 2005 remained stable (77 to 82%, p=0.159; 54 to 47%, p=0.108; respectively). Haemophilus influenzae (48 to 6%; p<0.001), Aspergillus species (18 to 9%; p=0.002) and Burkholderia cepacia complex (9 to 4%; p=0.041) prevalence decreased. Stenotrophomonas maltophilia and MRSA increased (1 to 4%, p=0.02; 1 to 6%, p=0.002, respectively).
  
  
  CONCLUSIONS
  P. aeruginosa colonisation has remained stable; there has been a decline in B. cepacia complex, H. influenzae and Aspergillus sp., and only a small increase in S. maltophilia and MRSA. Intensive antibiotic strategies have been employed, which, so far, have not resulted in clinically significant emergence of new pathogens.
authors.affiliation: Adult Cystic Fibrosis Dept, NHLI/Imperial College and Royal Brompton Hospital, London, United Kingdom.
authors.forename: F A
authors.initials: FA
authors.lastname: Millar
authors.forename: N J
authors.initials: NJ
authors.lastname: Simmonds
authors.forename: M E
authors.initials: ME
authors.lastname: Hodson
mesh_terms: D000293:Adolescent; D000328:Adult; D001424:Bacterial Infections / Q000453:epidemiology*; D003550:Cystic Fibrosis / Q000453:epidemiology*; D016208:Databases, Factual; D005260:Female; D006801:Humans; D008297:Male; D011014:Pneumonia / Q000453:epidemiology*; D015995:Prevalence; D055732:Pulmonary Aspergillosis / Q000453:epidemiology*; D012189:Retrospective Studies; D013183:Sputum / Q000382:microbiology; D006113:United Kingdom / Q000453:epidemiology; D055815:Young Adult