title: [Urticaria pigmentosa: a current approach].
abstract: The term urticaria pigmentosa (UP) denotes a heterogeneous group of disorders characterized by abnormal growth and accumulation of mast cells (MC) in the skin. Symptoms result from MC chemical mediator's release, pathologic infiltration of neoplastic MC in tissues or both. Multiple molecular, genetic and chromosomal defects seem contribute to an autonomous growth, but somatic c-kit D816V mutation is more frequently found, especially in systemic disease. The aim of this paper is to provide a current overview for a better understanding of the symptoms associated with this disease, to describe its classification, recent advances in its pathophysiology and its treatment.
authors.affiliation: Servicio de Dermatología, Hospital para el Niño IMIEM, Toluca, Estado de México. apederma@yahoo.com.mx
authors.forename: Antonio David
authors.initials: AD
authors.lastname: Pérez-Elizondo
authors.forename: Benjamín
authors.initials: B
authors.lastname: Zepeda-Ortega
authors.forename: Gladys Teresa
authors.initials: GT
authors.lastname: del Pino-Rojas
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D017668:Age of Onset; D002648:Child; D002675:Child, Preschool; D015897:Comorbidity; D003937:Diagnosis, Differential; D006633:Histamine Antagonists / Q000627:therapeutic use; D006801:Humans; D006967:Hypersensitivity / Q000453:epidemiology; D007223:Infant; D007231:Infant, Newborn; D008407:Mast Cells / Q000378:metabolism / Q000473:pathology; D008415:Mastocytosis / Q000145:classification; D020125:Mutation, Missense; D017354:Point Mutation; D019009:Proto-Oncogene Proteins c-kit / Q000235:genetics / Q000502:physiology; D019089:Stem Cell Factor / Q000502:physiology; D014582:Urticaria Pigmentosa / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000235:genetics / Q000473:pathology / Q000503:physiopathology
chemical_list: D000305:Adrenal Cortex Hormones; D006633:Histamine Antagonists; D019089:Stem Cell Factor; D019009:Proto-Oncogene Proteins c-kit