title: Late gadolinium enhancement-cardiovascular magnetic resonance identifies coronary artery disease as the aetiology of left ventricular dysfunction in acute new-onset congestive heart failure.
abstract: OBJECTIVE
  We evaluated the ability of late gadolinium enhancement (LGE) using cardiovascular magnetic resonance (CMR) to identify acute new-onset heart failure (HF) with left ventricular systolic dysfunction (LVSD), whether or not in relation to underlying coronary artery disease (CAD), in patients with no clinical evidence of associated ischaemic cardiomyopathy.
  
  
  RESULTS
  Hundred consecutive patients admitted with acute new-onset decompensated HF and EF <40%, with no clinical or electrocardiographic data suggestive of CAD. The patients were classified according to the presence or absence of significant CAD (stenosis > or =70% in at least one major vessel). Twenty-one patients (21%) had significant CAD. Seventy-nine (79%) had no lesions. Eighteen of the 21 patients (85%) with CAD had subendocardial/transmural LGE. In the diagnosis of CAD, LGE has a sensitivity of 85.7% (95% CI, 80-91) and specificity of 92.4% (95% CI, 87-96), respectively, with a negative predictive value of 96% (95% CI, 90-99). It has an area under the receiver operating characteristic curve of 0.906 (95% CI, 0.814-0.998).
  
  
  CONCLUSIONS
  In patients with new-onset HF and LVSD for whom there are no clinical and exploratory data suggestive of ischaemic heart disease, CMR with LGE is an excellent means of ruling out significant CAD and is a valid alternative to angiography.
authors.affiliation: Servicio de Cardiologia, Consorcio Hospital General Universitario de Valencia, Avda. Tres Cruces 2, 46014 Valencia, Spain.
authors.forename: Alfonso
authors.initials: A
authors.lastname: Valle-Muñoz
authors.forename: Jordi
authors.initials: J
authors.lastname: Estornell-Erill
authors.forename: Carlos J
authors.initials: CJ
authors.lastname: Soriano-Navarro
authors.forename: Mercedes
authors.initials: M
authors.lastname: Nadal-Barange
authors.forename: Nieves
authors.initials: N
authors.lastname: Martinez-Alzamora
authors.forename: Francisco
authors.initials: F
authors.lastname: Pomar-Domingo
authors.forename: Miguel
authors.initials: M
authors.lastname: Corbí-Pascual
authors.forename: Rafael
authors.initials: R
authors.lastname: Payá-Serrano
authors.forename: Francisco
authors.initials: F
authors.lastname: Ridocci-Soriano
mesh_terms: D019540:Area Under Curve; D016009:Chi-Square Distribution; D003287:Contrast Media; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000150:complications* / Q000503:physiopathology; D004562:Electrocardiography; D005260:Female; D019786:Gadolinium DTPA; D006333:Heart Failure / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D018709:Statistics, Nonparametric; D018487:Ventricular Dysfunction, Left / Q000209:etiology* / Q000503:physiopathology
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA