title: CSF lactate level: a useful diagnostic tool to differentiate acute bacterial and viral meningitis.
abstract: OBJECTIVE
  To evaluate the potential role of CSF lactate level in the diagnosis of acute bacterial meningitis and in the differentiation between viral and bacterial meningitis.
  
  
  METHODS
  This was a hospital based observational study, conducted at Infectious Diseases Unit, Rashid Hospital Dubai, United Arab Emirates, from July 2004 to June 2007. The patients with clinical diagnosis of acute bacterial meningitis and who had CSF Gram stain/culture positive, CSF analysis suggestive of bacterial meningitis with negative Gram stain and culture but blood culture positive for bacteria and patients with clinical diagnosis suggestive of viral meningitis supported by CSF chemical analysis with negative Gram stain and culture as well as negative blood culture for bacteria were included in the study. CT scan brain was done for all patients before lumber puncture and CSF and blood samples were collected immediately after admission. CSF chemical analysis including lactate level was done on first spinal tap. The CSF lactate level was tested by Enzymatic Colorimetric method.
  
  
  RESULTS
  A total 95 adult patients of acute meningitis (53 bacterial and 42 viral) fulfilled the inclusion criteria. Among 53 bacterial meningitis patients, Neisseria meningitides were isolated in 29 (54.7%), Strept. Pneumoniae in 18 (33.96%), Staph. Aureus in 2 (3.77%), Klebsiell Pneumoniae in 2 (3.77%), Strept. Agalactiae in 1 (1.8%) and E. Coli in 1 (1.8%). All the patients with bacterial meningitis had CSF lactate > 3.8 mmol/l except one, whereas none of the patients with viral meningitis had lactate level > 3.8 mmol/l. The mean CSF lactate level in bacterial meningitis cases amounted to 16.51 +/- 6.14 mmol/l, whereas it was significantly lower in viral group 2.36 +/- 0.6 mmol/l, p < .0001.
  
  
  CONCLUSIONS
  CSF lactate level was significantly high in bacterial than viral meningitis and it can provide pertinent, rapid and reliable diagnostic information. Furthermore, CSF lactate level can also differentiate bacterial meningitis from viral one in a quick and better way.
authors.affiliation: Infectious Disease Department, Rashid Hospital Dubai, United Arab Emirates.
authors.forename: Ali Hassan
authors.initials: AH
authors.lastname: Abro
authors.forename: Ahmed Saheh
authors.initials: AS
authors.lastname: Abdou
authors.forename: Abdulla M
authors.initials: AM
authors.lastname: Ustadi
authors.forename: Ahmed Alhaj
authors.initials: AA
authors.lastname: Saleh
authors.forename: Nadeem Javeed
authors.initials: NJ
authors.lastname: Younis
authors.forename: Wafa F
authors.initials: WF
authors.lastname: Doleh
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D002555:Cerebrospinal Fluid / Q000737:chemistry* / Q000382:microbiology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D019344:Lactic Acid / Q000134:cerebrospinal fluid*; D008297:Male; D016920:Meningitis, Bacterial / Q000134:cerebrospinal fluid / Q000175:diagnosis* / Q000382:microbiology; D008587:Meningitis, Viral / Q000134:cerebrospinal fluid / Q000175:diagnosis* / Q000382:microbiology / Q000821:virology; D008875:Middle Aged; D013997:Time Factors; D055815:Young Adult
chemical_list: D019344:Lactic Acid