title: Aaptamine alkaloids from the Vietnamese sponge Aaptos sp.
abstract: A series of aaptamines, including one new alkaloid (1), were isolated from the marine sponge Aaptos sp. collected in Vietnamese waters. The structure of 1 was elucidated using NMR and HRESIMS, as well as by chemical transformation of 1 to the previously known aaptamine and established as 3-N-morpholinyl-9-demethyl(oxy)aaptamine. The isolated compounds showed a potential cancer preventive activity.
authors.affiliation: Laboratory of Chemistry MaNaPro, Pacific Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Vladivostok, Russia. shubina@piboc.dvo.ru
authors.forename: Larisa K
authors.initials: LK
authors.lastname: Shubina
authors.forename: Anatoly I
authors.initials: AI
authors.lastname: Kalinovsky
authors.forename: Sergey N
authors.initials: SN
authors.lastname: Fedorov
authors.forename: Oleg S
authors.initials: OS
authors.lastname: Radchenko
authors.forename: Vladimir A
authors.initials: VA
authors.lastname: Denisenko
authors.forename: Pavel S
authors.initials: PS
authors.lastname: Dmitrenok
authors.forename: Sergey A
authors.initials: SA
authors.lastname: Dyshlovoy
authors.forename: Vladimir B
authors.initials: VB
authors.lastname: Krasokhin
authors.forename: Valentin A
authors.initials: VA
authors.lastname: Stonik
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification*; D000818:Animals; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008958:Models, Molecular; D009287:Naphthyridines / Q000737:chemistry / Q000302:isolation & purification*; D011161:Porifera / Q000737:chemistry*; D012623:Seawater; D014744:Vietnam
chemical_list: D000470:Alkaloids; D009287:Naphthyridines; C043986:aaptamine