Disseminated Cryptococcus neoformans: case report and review of the literature.
Cryptococcus neoformans is a yeastlike encapsulated basidiomycetous fungus that is able to cross the blood-brain barrier and cause meningitis in both immunocompetent and immunocompromised individuals. Cryptococcus neoformans has emerged as a major opportunistic pathogen because of the widespread use of immunosuppressive therapy. It causes most cryptococcal infections in humans, and disseminated infection can have cutaneous manifestations. We report a rare case of disseminated C neoformans in a 52-year-old man who underwent an orthotopic liver transplant. We also provide a concise review of the literature on C neoformans, including its associations, histology, and treatment.
Patel
Nisha C
NC
Georgetown University Hospital, Washington, DC, USA.
Ewanowski
Christopher
C
Kupiec-Banasikowska
Agnieszka
A
Hogan
Kevin P
KP
D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D003453:Cryptococcosis / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology*; D003455:Cryptococcus neoformans / Q000302:isolation & purification*; D005437:Flucytosine / Q000627:therapeutic use; D006801:Humans; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
D000935:Antifungal Agents; D000666:Amphotericin B; D005437:Flucytosine