Neural crest lineage segregation: a blueprint for periodontal regeneration.
During the recent decade, the periodontal attachment apparatus has become one of the premier areas of the body for the development of novel tissue-engineering strategies. In the present review, we describe a developmental biology approach to characterize current concepts in periodontal regeneration and to discuss strategies for future applications in periodontal therapies. To decipher the developmental make-up of the periodontal region, we have followed the path of the migratory neural crest, since it gives rise to periodontal progenitor tissues, which in turn are subjected to the influence of diverse craniofacial extracellular matrices and peptide growth factors. Based on this developmental perspective, we have conducted a systematic analysis of the factors, progenitor cells, and matrices used in current periodontal tissue-engineering approaches. We propose that the developmental history of a tissue is a highly instructive design template for the discovery of novel bioengineering tools and approaches.
Luan
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Brodie Laboratory for Craniofacial Genetics, Department of Oral Biology, UIC College of Dentistry, The University of Illinois at Chicago, 801 South Paulina, M/C 841, Chicago, IL 60612, USA. luan@uic.edu
Dangaria
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Ito
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Walker
C G
CG
Jin
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Schmidt
M K
MK
Galang
M T
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Druzinsky
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R
D002454:Cell Differentiation / Q000502:physiology; D019070:Cell Lineage / Q000502:physiology*; D005109:Extracellular Matrix / Q000502:physiology; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology; D039902:Multipotent Stem Cells / Q000502:physiology; D009432:Neural Crest / Q000166:cytology*; D010519:Periodontium / Q000502:physiology*; D012038:Regeneration / Q000502:physiology*; D023822:Tissue Engineering / Q000379:methods; D054457:Tissue Scaffolds
D036341:Intercellular Signaling Peptides and Proteins