title: Synthesis and cytotoxic evaluation of 6-(3-pyrazolylpropyl) derivatives of 1,4-naphthohydroquinone-1,4-diacetate.
abstract: Several new 6-(3-pyrazolylpropyl) derivatives of 1,4-naphthohydroquinone-1,4-diacetate (NHQ-DA) have been prepared by chemical modifications of the Diels-Alder adduct of alpha-myrcene and 1,4-benzoquinone. All these new compounds and precursors have been evaluated in vitro for their cytotoxicity against cultured human cancer cells of MB-231 breast-adeno carcinoma, A-549 lung carcinoma, and HT-29 colon carcinoma. GI(50) values ranged in and below the micromolar concentration level.
authors.affiliation: Instituto de Química, Facultad de Ciencias Bsicas y Matemticas, Pontificia Universidad Católica de Valparaíso, Valparaiso, Chile. amolinar@ucv.cl
authors.forename: Aurora
authors.initials: A
authors.lastname: Molinari
authors.forename: Alfonso
authors.initials: A
authors.lastname: Oliva
authors.forename: Claudia
authors.initials: C
authors.lastname: Ojeda
authors.forename: José M Miguel
authors.initials: JM
authors.lastname: del Corral
authors.forename: M Angeles
authors.initials: MA
authors.lastname: Castro
authors.forename: Carmen
authors.initials: C
authors.lastname: Cuevas
authors.forename: Arturo
authors.initials: A
authors.lastname: San Feliciano
mesh_terms: D000085:Acetates / Q000138:chemical synthesis / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D019073:HT29 Cells; D006801:Humans; D006873:Hydroquinones / Q000138:chemical synthesis / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D000085:Acetates; D000970:Antineoplastic Agents; D006873:Hydroquinones; C063601:1,4-naphthohydroquinone