Sensitivity of fluorophore-quencher labeled microbubbles to externally applied static pressure.
A fluorophore-quencher (F-Q) labeled microbubble system is proposed as a sensor for measuring externally applied static pressure distribution in a tumor. To quantify the sensitivity of such an F-Q bubble system to the externally applied pressure, a model describing bubble response to the static pressure was derived. Additionally, a model connecting the fluorescence lifetime and bubble radius was developed for the basic F-Q bubble system. The sensitivity is quantified based on these models given typical parameters. Results show that it is possible to resolve as low as 1 mm Hg pressure variation when both the F-Q bubble system and the measurement system are optimized. Strategies for optimizing an F-Q bubble system are discussed.
Yuan
Baohong
B
Department of Biomedical Engineering, Catholic University of America, Washington, DC 20064, USA. yuan@cua.edu
D001696:Biomechanical Phenomena; D005240:Feasibility Studies; D005453:Fluorescence; D005456:Fluorescent Dyes / Q000378:metabolism*; D045423:Microbubbles; D008954:Models, Biological; D009369:Neoplasms / Q000378:metabolism / Q000503:physiopathology; D011312:Pressure; D013194:Staining and Labeling; D013500:Surface Tension; D013997:Time Factors
D005456:Fluorescent Dyes