title: Subthalamic nucleus location: relationships between stereotactic AC-PC-based diagrams and MRI anatomy-based contours.
abstract: Subthalamic nucleus (STN) targeting is classically performed based on AC-PC probabilistic position. Nevertheless, MRI allows direct visualization and targeting. We aimed to compare the position localized on MR images with standard stereotactic diagrams. The STN was manually contoured on MR images (22 Parkinson's disease patients); boundaries were simplified in a schematic polygonal form. Front and lateral stereotactic diagrams were constructed according to Talairach and Benabid. We compared x, y and z coordinates of the geometrical center of MRI-based polygons and stereotactic diagrams (Wilcoxon matched-pairs tests). There was significant discordance between MRI-based polygons and AC-PC-based images. MRI shows the STN as more posterior, medial and slightly inferior.
authors.affiliation: Equipe de Recherche en Signal et Imagerie Médicale, EA 3295, Faculté de Médecine, Université Clermont 1, Clermont-Ferrand, France. francois.caire@chu-limoges.fr
authors.forename: François
authors.initials: F
authors.lastname: Caire
authors.forename: Lemlih
authors.initials: L
authors.lastname: Ouchchane
authors.forename: Jérôme
authors.initials: J
authors.lastname: Coste
authors.forename: Jean
authors.initials: J
authors.lastname: Gabrillargues
authors.forename: Philippe
authors.initials: P
authors.lastname: Derost
authors.forename: Miguel
authors.initials: M
authors.lastname: Ulla
authors.forename: Franck
authors.initials: F
authors.lastname: Durif
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Lemaire
mesh_terms: D000368:Aged; D046690:Deep Brain Stimulation; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D008953:Models, Anatomic; D008962:Models, Theoretical; D010300:Parkinson Disease / Q000473:pathology / Q000628:therapy; D013238:Stereotaxic Techniques; D020531:Subthalamic Nucleus / Q000473:pathology*; D020542:Third Ventricle / Q000473:pathology*