Patient HSP70-hom TG haplotype is associated with decreased transplant-related mortality and improved survival after sibling HLA-matched hematopoietic stem cell transplantation.
Heat shock protein 70-hom (HSP70-hom) plays an important role in protein folding and immune responses. Therefore, HSP70-hom gene polymorphisms may act as important factors in predicting the prognosis of patients receiving allogeneic hematopoietic stem cell transplantation (HSCT). To evaluate the role of HSP70-hom gene polymorphisms in the prognosis of patients receiving sibling human leukocyte antigen (HLA)-matched allogeneic HSCT, the HSP70-hom polymorphisms, T2437C and G2763A, were genotyped in 147 patients receiving sibling HLA-matched allogeneic HSCT. Individual diplotypes were estimated from genotype data of the two HSP70-hom polymorphisms using the expectation maximization algorithm. Patients with the 2763GG or GA genotype showed longer overall survival compared with those with the 2763AA genotype, and patients with a TG haplotype (TG/TA, TG/TG or TG/CG) also showed longer overall survival compared with those with a non-TG haplotype (TA/TA or TA/CG) (both G2763A genotype and diplotype, p<0.01). Moreover, the 2437TT genotype was found to be protective for treatment-related death compared with the 2437TC genotype, and a TG haplotype was found to be very protective for treatment-related death compared with a non-TG haplotype (T2437C genotype, p=0.04; and diplotype, p=0.02). Therefore, our results suggest that HSP70-hom polymorphisms play an important role in the prognosis of patients receiving sibling HLA-matched allogeneic HSCT.
Kim
Inho
I
Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
Kim
Jin Hee
JH
Rhee
Ji Young
JY
Kim
Jin Won
JW
Cho
Hyeon Jin
HJ
Cho
Eun-Young
EY
Lee
Jong-Eun
JE
Hong
Yun-Chul
YC
Park
Sung Sup
SS
Yoon
Sung-Soo
SS
Park
Myoung Hee
MH
Park
Seonyang
S
Kim
Byoung Kook
BK
D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006086:Graft vs Host Disease / Q000235:genetics* / Q000401:mortality* / Q000517:prevention & control; D006680:HLA Antigens / Q000235:genetics*; D018840:HSP70 Heat-Shock Proteins / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics*; D019337:Hematologic Neoplasms / Q000235:genetics / Q000401:mortality* / Q000628:therapy; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D035781:Siblings; D015996:Survival Rate; D055815:Young Adult
D006680:HLA Antigens; D018840:HSP70 Heat-Shock Proteins