title: Management of hydrocephalus in patients with tuberculous meningitis.
abstract: Hydrocephalus is one of the commonest complications of tuberculous meningitis (TBM) occurring in up to 85% of children with the disease. It is more severe in children than in adults. It could be either of the communicating type or the obstructive type with the former being more frequently seen. The Vellore grading system for clinical grading of patients with TBM and hydrocephalus with grade I being the best grade and grade IV being the worst grade has been validated by several authors. The management of hydrocephalus can include medical therapy with dehydrating agents and steroids for patients in good grades and those with communicating hydrocephalus. However, surgery is required for patients with obstructive hydrocephalus and those in poor grades. Surgery can involve either a ventriculo-peritoneal shunt or endoscopic third ventriculostomy (ETV). Complications of shunt surgery in patients with TBM and hydrocephalus are high with frequent shunt obstructions and shunt infections requiring repeated revisions. ETV has variable success in these patients and is generally not advisable in patients in the acute stages of the disease. Mortality on long-term follow up has been reported to vary from 10.5% to 57.1% in those with altered sensorium prior to surgery and 0 to 12.5% in patients with normal sensorium. Surgery for patients in Vellore grade IV is usually associated with a poor outcome and high mortality and therefore, its utility in these patients is debatable.
authors.affiliation: Department of Neurological Sciences, Christian Medical College, Vellore, India. rajshekhar@cmcvellore.ac.in
authors.forename: Vedantam
authors.initials: V
authors.lastname: Rajshekhar
mesh_terms: D003952:Diagnostic Imaging / Q000379:methods; D006801:Humans; D006849:Hydrocephalus / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology / Q000601:surgery*; D016896:Treatment Outcome; D014390:Tuberculosis, Meningeal / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology / Q000601:surgery*