Preventing viral-induced type 1 diabetes.
The development of type 1 diabetes is, in part, dictated by the failure of regulatory T cells to maintain peripheral tolerance. As such, therapies aimed at correcting the declining function of regulatory T cells have been the subject of intense investigation. In this review, we discuss the potential of regulatory T cells to suppress autoreactive responses and prevent type 1 diabetes induced by viral infection while maintaining protective antiviral immunity.
Richer
Martin Joseph
MJ
Department of Microbiology and Immunology, The University of British Columbia, Vancouver, British Columbia, Canada.
Horwitz
Marc Steven
MS
D000818:Animals; D015551:Autoimmunity / Q000187:drug effects / Q000276:immunology; D017252:CD3 Complex / Q000276:immunology; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology / Q000276:immunology* / Q000517:prevention & control; D006801:Humans; D016853:Muromonab-CD3 / Q000627:therapeutic use; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects / Q000276:immunology*; D014777:Virus Diseases / Q000150:complications / Q000276:immunology* / Q000517:prevention & control
D017252:CD3 Complex; D016853:Muromonab-CD3