title: Are recently identified genetic variants regulating BMI in the general population associated with anorexia nervosa?
abstract: The influence of body mass index (BMI) on susceptibility to anorexia nervosa (AN) is not clear. Recently published genome-wide association (GWA) studies of the general population identified several variants influencing BMI. We genotyped these variants in an AN sample to test for association and to investigate a combined effect of BMI-increasing alleles (as determined in the original GWA studies) on the risk of developing the disease. Individual single nucleotide polymorphisms (SNPs) were tested for association with AN in a sample of 267 AN patients and 1,636 population controls. A logistic regression for the combined effect of BMI-increasing alleles included 225 cases and 1,351 controls. We found no significant association between individual SNPs and AN. The analysis of a combined effect of BMI-increasing alleles showed absence of association with the investigated condition. The percentages of BMI-increasing alleles were equal between cases and controls. This study found no evidence that genetic variants regulating BMI in the general population are significantly associated with susceptibility to AN.
authors.affiliation: Department of Neuroscience & Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands.
authors.forename: Marek K
authors.initials: MK
authors.lastname: Brandys
authors.affiliation: Department of Child and Adolescent Psychiatry, University Medical Centre, Utrecht, The Netherlands.|Rintveld Centre for Eating Disorders, Altrecht Mental Health Institute, Zeist, The Netherlands.
authors.forename: Annemarie A
authors.initials: AA
authors.lastname: van Elburg
authors.affiliation: Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.
authors.forename: Ruth J F
authors.initials: RJF
authors.lastname: Loos
authors.affiliation: Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.|Complex Genetics Section, Department of Medical Genetics-DBG, University Medical Center Utrecht, Utrecht, The Netherlands.
authors.forename: Florianne
authors.initials: F
authors.lastname: Bauer
authors.affiliation: Department of Neuroscience & Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands.
authors.forename: Judith
authors.initials: J
authors.lastname: Hendriks
authors.affiliation: Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
authors.forename: Yvonne T
authors.initials: YT
authors.lastname: van der Schouw
authors.affiliation: Department of Neuroscience & Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands.
authors.forename: Roger A H
authors.initials: RAH
authors.lastname: Adan
mesh_terms: D000328:Adult; D000483:Alleles; D000856:Anorexia Nervosa / Q000235:genetics*; D015992:Body Mass Index; D016022:Case-Control Studies; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012044:Regression Analysis