Floating-Harbor syndrome and intramedullary spinal cord ganglioglioma: case report and observations from the literature.
We report on a 5-year-old male with expressive language delay, developmental delay, short stature, and facial anomalies consistent with Floating-Harbor syndrome (FHS). In addition, he developed an intramedullary ganglioglioma. This is the first reported case of a tumor associated with FHS, and may represent an as yet undefined genetic link between spinal cord tumors and FHS, adding this syndrome to the growing list of disorders with a predisposition for tumor development.
Nelson
Rachel A
RA
Department of Pediatrics, University of California at Davis, Sacramento, California 95817, USA.
McNamara
Michelle
M
Ellis
William
W
Stein-Wexler
Rebecca
R
Moghaddam
Billur
B
Zwerdling
Theodore
T
D002675:Child, Preschool; D019465:Craniofacial Abnormalities / Q000150:complications* / Q000175:diagnosis; D002658:Developmental Disabilities / Q000150:complications* / Q000175:diagnosis; D018303:Ganglioglioma / Q000150:complications* / Q000175:diagnosis; D006130:Growth Disorders / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D007805:Language Development Disorders / Q000150:complications / Q000175:diagnosis; D008297:Male; D013120:Spinal Cord Neoplasms / Q000150:complications* / Q000175:diagnosis; D013577:Syndrome