Enhancement of anti-tumor immunity by photodynamic therapy.
Photodynamic therapy (PDT) is an FDA-approved modality that rapidly eliminates local tumors, resulting in cure of early disease and palliation of advanced disease. PDT was originally considered to be a local treatment; however, both pre-clinical and clinical studies have shown that local PDT treatment of tumors can enhance systemic anti-tumor immunity. The current state of investigations into the ability of PDT to enhance anti-tumor immunity, the mechanisms behind this enhancement and the future of PDT as an immunotherapy are addressed in this review.
Gollnick
Sandra O
SO
Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA. Sandra.gollnick@roswellpark.org
Brackett
Craig M
CM
D000818:Animals; D019496:Cancer Vaccines / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects / Q000276:immunology; D009369:Neoplasms / Q000188:drug therapy* / Q000276:immunology*; D010778:Photochemotherapy
D019496:Cancer Vaccines