Association of IL-15 polymorphisms with bone mineral density in postmenopausal Korean women.
Interleukin-15 (IL-15) has been suggested to participate in bone metabolism by stimulating osteoclast differentiation and mediating inflammatory bone loss. This study investigated the effect of IL-15 gene polymorphisms on the bone mineral density (BMD) and bone fracture rates of postmenopausal women. Sequencing of the IL-15 gene in 24 Koreans revealed 16 single-nucleotide polymorphisms (SNPs), of which five were selected for further study. Postmenopausal Korean women (n = 844) were genotyped for these SNPs, and their BMDs and risk of fractures were assessed. It was found that the +20A > G, +13467C > A, +13653A > T, and +13815A > T IL-15 gene polymorphisms were significantly associated with the BMD of the lumbar spine and femoral neck and that their effects were gene-dose dependent. BMD was reduced when the minor allele of +13467A and +13653T or the common allele of +20A and +13815A was present. Haplotype (ht) analyses revealed that ht1 (GCAT) and ht2 (AATA) were associated with BMD of the lumbar spine and femoral neck. However, there was no association between the risk of fracture and IL-15 SNPs or hts. These results suggest that the +20A > G, +13467C > A, +13653A > T, and +13815A > T SNPs in the IL-15 gene affect BMD and, thus, could be genetic markers of osteoporosis.
Koh
Jung-Min
JM
Skeletal Diseases Genome Research Center, Kyungpook National University Hospital, Daegu 700-412, Korea.
Oh
Bermseok
B
Ha
Mi-Hyun
MH
Cho
Kyu-Woan
KW
Lee
Jong-Young
JY
Park
Byung Lae
BL
Shin
Hyoung Doo
HD
Bae
Myung-Ae
MA
Kim
Hyun-Ju
HJ
Hong
Jung Min
JM
Kim
Tae-Ho
TH
Shin
Hong-In
HI
Lee
Seung Hun
SH
Kim
Ghi Su
GS
Kim
Shin-Yoon
SY
Park
Eui Kyun
EK
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D015519:Bone Density / Q000235:genetics*; D005260:Female; D005272:Femur Neck / Q000378:metabolism; D050723:Fractures, Bone / Q000235:genetics*; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D019409:Interleukin-15 / Q000235:genetics*; D007723:Korea; D008159:Lumbar Vertebrae / Q000378:metabolism; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
D005819:Genetic Markers; D019409:Interleukin-15