Fluoride-containing gels, mouth rinses and varnishes: an update of evidence of efficacy.
OBJECTIVE
This was to review and update knowledge from presently available systematic reviews of clinical trials on the effect of fluoride containing gels, mouth rinses and varnishes.


METHODS
The review was based on an electronic search of three data bases (PubMed 2000 to 2008, EMBASE 2000- 2009, Cochrane 2000-2008) using a search profile similar to that used in previous Cochrane reviews on the caries-preventive effect of topical fluoride methods. Only randomized and semi-randomized trials were included.


RESULTS
Four new studies were identified on fluoride-containing gels, one on fluoride mouth rinses and four on fluoride-containing varnishes. Prevented fractions obtained in the permanent dentition were consistent with the estimates found in previous reviews, while the effect obtained on caries in the primary dentition remains uncertain. The only study that compared the effect of different fluoride compounds, could not find any difference.


CONCLUSIONS
The effect of the three methods on caries in the permanent dentition is well described, while the effect on caries in the primary dentition remains to be determined. The effect of choice of fluoride compound is also not known.
Poulsen
S
S
Department of Pediatric Dentistry, School of Dentistry, Faculty of Health Sciences, Aarhus University, Aarhus C, Denmark. spoulsen@odont.au.dk
D002327:Cariostatic Agents / Q000627:therapeutic use*; D003731:Dental Caries / Q000517:prevention & control*; D005459:Fluorides / Q000627:therapeutic use*; D005460:Fluorides, Topical / Q000627:therapeutic use*; D005782:Gels; D006801:Humans; D009067:Mouthwashes / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic; D014070:Tooth / Q000187:drug effects; D014094:Tooth, Deciduous / Q000187:drug effects
D002327:Cariostatic Agents; D005460:Fluorides, Topical; D005782:Gels; D009067:Mouthwashes; D005459:Fluorides