Synthesis of exciton-controlled fluorescent probes for RNA imaging.
The excitonic interaction of thiazole orange dyes is known to suppress fluorescence emission. We have developed hybridization-sensitive fluorescent probes utilizing the excitonic interaction of two thiazole orange dyes connected to the probes. Here, we report nuclease-resistant hybridization-sensitive probes for long-term intracellular RNA imaging.
Ikeda
Shuji
S
RIKEN Advanced Science Institute, Wako, Saitama 351-0198, Japan.
Kubota
Takeshi
T
Yanagisawa
Hiroyuki
H
Yuki
Mizue
M
Okamoto
Akimitsu
A
D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D012313:RNA / Q000032:analysis*; D013050:Spectrometry, Fluorescence
D005456:Fluorescent Dyes; D012313:RNA