Shugoshin and PP2A: collaborating to keep chromosomes connected.
Timely release of sister chromatid cohesion is essential for accurate chromosome segregation during cell division. Shugoshin forms a complex with the phosphatase PP2A that has been proposed to dephosphorylate cohesin proteins to prevent premature loss of centromeric cohesion. A recent study in Molecular Cell by Xu et al. presents the structure of Shugoshin bound to PP2A and provides evidence that this interaction is required for cohesion protection.
Kateneva
Anna V
AV
Division of Rheumatology, Immunology and Allergy, Brigham & Women's Hospital, Harvard Medical School, Smith Building Room 538A, 1 Jimmy Fund Way, Boston, MA 02115, USA.
Higgins
Jonathan M G
JM
D000818:Animals; D018797:Cell Cycle Proteins / Q000502:physiology*; D002460:Cell Line; D002503:Centromere / Q000648:ultrastructure; D020090:Chromosome Segregation; D002875:Chromosomes / Q000378:metabolism*; D019281:Dimerization; D006801:Humans; D008540:Meiosis; D051379:Mice; D008938:Mitosis; D011485:Protein Binding; D054648:Protein Phosphatase 2 / Q000502:physiology*
D018797:Cell Cycle Proteins; C496644:SGO1 protein, human; D054648:Protein Phosphatase 2