title: Precursor T-lymphoblastic lymphoma as a secondary malignancy in a young patient after successful treatment of acute promyelocytic leukemia.
abstract: BACKGROUND
  Acute promyelocytic leukemia (APL) is a relatively rare subtype of acute myeloid leukemia. It has become the best curable subtype of acute leukemias in adults due to the inclusion of all-trans-retinoic acid (ATRA) in the treatment. Despite the efficacy of ATRA, chemotherapy must be added in APL patients in order to maintain durable complete remission. However, chemotherapy administration is inevitably related to many complications, including the risk of secondary malignancies. T-lymphoblastic lymphoma (T-LBL) is an infrequent disease that belongs to the group of highly aggressive lymphomas.
  
  
  METHODS
  The authors describe the case of a 25-year-old woman who was treated for APL in 2002 and developed precursor T-LBL 5 years later.
  
  
  CONCLUSIONS
  Several cases of secondary acute lymphoblastic leukemias in 'cured' APL patients have been described, but probably no patient with secondary precursor T-LBL. Secondary malignancy has become one of the topics discussed (not only) in APL patients. It is apparently related to the excellent treatment outcomes and long-term survival. Better tailored treatment based on relevant prognostic factors allowing chemotherapy reduction or omission in some patients is needed.
authors.affiliation: Department of Hemato-Oncology, University Hospital Olomouc, Olomouc, Czech Republic. tszotkowski@seznam.cz
authors.forename: Tomas
authors.initials: T
authors.lastname: Szotkowski
authors.forename: Marie
authors.initials: M
authors.lastname: Jarosova
authors.forename: Edgar
authors.initials: E
authors.lastname: Faber
authors.forename: Jaromir
authors.initials: J
authors.lastname: Hubacek
authors.forename: Antonin
authors.initials: A
authors.lastname: Hlusi
authors.forename: Tomas
authors.initials: T
authors.lastname: Papajik
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Pikalova
authors.forename: Ladislava
authors.initials: L
authors.lastname: Kucerova
authors.forename: Milena
authors.initials: M
authors.lastname: Holzerova
authors.forename: Miroslava
authors.initials: M
authors.lastname: Budikova
authors.forename: Eva
authors.initials: E
authors.lastname: Buriankova
authors.forename: Radek
authors.initials: R
authors.lastname: Plachy
authors.forename: Jarmila
authors.initials: J
authors.lastname: Potomkova
authors.forename: Natalie
authors.initials: N
authors.lastname: Klusova
authors.forename: Romana
authors.initials: R
authors.lastname: Szotkowska
authors.forename: Karel
authors.initials: K
authors.lastname: Indrak
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000150:complications* / Q000628:therapy*; D054218:Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis* / Q000209:etiology* / Q000517:prevention & control