title: Serum leptin levels in older patients with hip fracture--impact on peri-operative myocardial injury.
abstract: To evaluate whether there is a relationship between admission serum leptin concentrations and peri-operative myocardial injury, 238 consecutive older patients (mean age 81.9+/-7.9 years; 172 women) with low-trauma hip fracture were assessed. Myocardial injury as defined by elevated serum cardiac troponin I was associated with lower leptin levels analyzed as continuous or categorical variables. Patients with serum leptin concentrations <12ng/ml (medium value) had a two-fold greater increased risk for such complications compared with those with higher leptin levels (odd ratio 2.13, 95% confidence interval 1.06-4.28; p=0.033). This association remained significant after adjustments for age, gender, clinical (history of coronary artery disease [CAD], stroke, hypertension, diabetes, dementia), hematological (red, white, and lymphocyte count, hemoglobin, hematocrit), metabolic (parathyroid hormone [PTH], albumin), renal(creatinine, urea, glomerular filtration rate [GFR]), and inflammatory (C-reactive protein [CRP], ferritin) factors. The predictive value of lower leptin levels increased significantly when used in combination with traditional risk factors for myocardial injury.
authors.affiliation: Department of Geriatric Medicine, The Canberra Hospital and Australian National University Medical School, ACT, Australia. alex.fisher@act.gov.au
authors.forename: A A
authors.initials: AA
authors.lastname: Fisher
authors.forename: S L
authors.initials: SL
authors.lastname: Goh
authors.forename: W
authors.initials: W
authors.lastname: Srikusalankul
authors.forename: E N
authors.initials: EN
authors.lastname: Southcott
authors.forename: M W
authors.initials: MW
authors.lastname: Davis
mesh_terms: D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D005260:Female; D006620:Hip Fractures / Q000097:blood* / Q000601:surgery; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D011379:Prognosis; D012307:Risk Factors; D019210:Troponin I / Q000097:blood*
chemical_list: D015415:Biomarkers; D020738:Leptin; D019210:Troponin I