Review of current theories for abdominal aortic aneurysm pathogenesis.
Atherosclerotic plaques are a feature of abdominal aortic aneurysms (AAAs). Atherosclerosis and AAA appear to share similar risk factors. These observations have led to the conclusion that AAAs are a consequence of advanced atherosclerosis.This review explores current theories regarding the pathogenesis of AAA and their implications for treatment.A systematic literature search was conducted using the search terms abdominal aortic aneurysm, atherosclerosis, pathogenesis, and systemic disease. Articles were categorized according to the association of AAAs with atherosclerosis, arteriomegaly, peripheral aneurysm, systemic expression, genetics, autoimmunity, oxidative stress, and systemic disease. Twenty-nine articles reporting changes in the systemic vasculature associated with AAA and 12 articles examining the shared risk factor hypothesis were identified.There is insufficient evidence to confirm that AAAs are the result of advanced atherosclerosis. The bulk of evidence points to AAA disease being a systemic disease of the vasculature, with a predetermined genetic susceptibility leading to a phenotype governed by environmental factors.
Nordon
Ian M
IM
St George's Vascular Institute, St James' Wing, St George's Hospital, London, UK. inordon@sgul.ac.uk
Hinchliffe
Robert J
RJ
Holt
Peter J
PJ
Loftus
Ian M
IM
Thompson
Matthew M
MM
D017544:Aortic Aneurysm, Abdominal / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D050197:Atherosclerosis / Q000150:complications; D015551:Autoimmunity; D004108:Dilatation, Pathologic / Q000150:complications; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D018384:Oxidative Stress; D012307:Risk Factors