title: Clinical and resistance consequences of misquantification of plasma and cerebrospinal fluid human immunodeficiency virus type 1 (HIV-1) RNA in samples from an HIV-1 subtype G-infected patient.
abstract: Human immunodeficiency virus (HIV) load is the main marker used to monitor antiviral treatment efficacy and resistance. We report a case of underquantification of HIV type 1 (HIV-1) RNA in plasma and cerebrospinal fluid from an HIV-1 subtype G-infected woman, leading to delayed diagnosis of HIV encephalitis and to the emergence of drug resistance.
authors.affiliation: Department of Virology, Saint-Louis Hospital, 1 avenue Claude Vellefaux, 75010 Paris, France. constance.delaugerre@sls.aphp.fr
authors.forename: Constance
authors.initials: C
authors.lastname: Delaugerre
authors.forename: Blandine
authors.initials: B
authors.lastname: Denis
authors.forename: Gilles
authors.initials: G
authors.lastname: Peytavin
authors.forename: Pierre
authors.initials: P
authors.lastname: Palmer
authors.forename: Thomas
authors.initials: T
authors.lastname: Mourez
authors.forename: Jerôme
authors.initials: J
authors.lastname: Le Goff
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Molina
authors.forename: François
authors.initials: F
authors.lastname: Simon
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D002555:Cerebrospinal Fluid / Q000821:virology*; D003951:Diagnostic Errors; D024882:Drug Resistance, Viral; D018792:Encephalitis, Viral; D005260:Female; D015658:HIV Infections / Q000821:virology*; D015497:HIV-1 / Q000302:isolation & purification*; D006801:Humans; D010949:Plasma / Q000821:virology*; D012367:RNA, Viral / Q000097:blood / Q000134:cerebrospinal fluid; D019562:Viral Load
chemical_list: D019380:Anti-HIV Agents; D012367:RNA, Viral