title: Two-year clinical follow-up of the unrestricted use of the paclitaxel-eluting stent compared to the sirolimus-eluting stent as part of the Taxus-Stent Evaluated at Rotterdam Cardiology Hospital (T-SEARCH) registry.
abstract: OBJECTIVE
  To investigate the medium term (2 year) clinical outcome of the use of the paclitaxel-eluting stent (PES) compared to the sirolimus-eluting stent (SES). To date, there are no direct comparative data on the efficacy of these stents over medium term follow-up. Furthermore, a possible late restenotic phenomenon has not been excluded.
  
  
  RESULTS
  The Taxus-Stent Evaluated At Rotterdam Cardiology Hospital (T-SEARCH) registry compared 576 consecutive "all-comer" patients, exclusively treated with PES, with 508 patients who received SES from the RESEARCH registry in the preceding period. Patients were enrolled irrespective of clinical or angiographic features. At 2 years, major adverse cardiac event (death, myocardial infarction or target vessel revascularisation) rates were comparable in the two groups: 15.4% in the SES group versus 18.9% in the PES group (HR 1.26, 95% CI 0.94-1.69, p=0.12). Correcting for differences in both groups resulted in an adjusted HR of 1.11 (95% CI 0.82-1.50, p=0.51, using significant univariate variables). Target vessel revascularisation was 8.0% in the SES group compared with 9.6% in the PES group (HR 1.23, 95% CI 0.81-1.86, p=0.33).
  
  
  CONCLUSIONS
  The unrestricted use of SES and PES was safe at two years of follow-up. No significant difference was found between the two devices in terms of death or MI, MACE, TVR or TLR. No late clinical restenotic phenomenon was observed.
authors.affiliation: Thoraxcenter, Erasmus Medical Centre, Rotterdam, The Netherlands.
authors.forename: Joost
authors.initials: J
authors.lastname: Daemen
authors.forename: Keiichi
authors.initials: K
authors.lastname: Tsuchida
authors.forename: Giulio G
authors.initials: GG
authors.lastname: Stefanini
authors.forename: Sophia
authors.initials: S
authors.lastname: Vaina
authors.forename: Neville
authors.initials: N
authors.lastname: Kukreja
authors.forename: Peter P T
authors.initials: PP
authors.lastname: de Jaegere
authors.forename: Andrew T L
authors.initials: AT
authors.lastname: Ong
authors.forename: Ron T
authors.initials: RT
authors.lastname: van Domburg
authors.forename: Patrick W
authors.initials: PW
authors.lastname: Serruys