On the sorting of the repertoire: an analysis of Cohn's challenge to integrity (Dembic), Round 2.
In analyzing the integrity model and other context-based models, Melvin Cohn excluded the possibility that regulatory T cells or germline selected mechanisms can contribute to defining the specificity of immune responses. Here I discuss in greater detail how both the experimental data and a quantitative view of the evolution of immune control mechanisms challenge Cohn's arguments.
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Department of Surgery and Medical Microbiology and Immunology, Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada. colinand@ualberta.ca
D000818:Animals; D005075:Biological Evolution; D006801:Humans; D007107:Immune System / Q000502:physiology*; D018448:Models, Immunological; D050378:T-Lymphocytes, Regulatory / Q000276:immunology