title: [Possibilities of dopplerography in assessment of functional state of the heart in patients with arterial hypertension with impaired diastolic cardiac function].
abstract: The search for reliable Dopplerographic markers of incipient diastolic cardiac failure became especially actual in recent years. We examined 71 patients with II degree arterial hypertension (AH) with Dopplerographical signs of diastolic left ventricular (LV) dysfunction. For the assessment of severity of diastolic dysfunction we carried out complex Dopplerographic evaluation of maximal velocities of transmitral blood flow and motion of fibrous annulus of the mitral valve (MV). We revealed relationships between standard parameters of transmitral flow, Doppler visualization of tissues, and tolerance to physical effort. We found moderate negative correlation between exercise tolerance and maximal velocity of movement of lateral part of MV fibrous annulus E' (r=-0.4, p=<0.001), E/E' ratio (r=-0.65, p=<0.001). E/E' ratio had the strongest linear relationship with exercise tolerance. We showed that combined assessment of velocity of early LV diastolic filling and velocity of MV fibrous annulus motion (E/E') was possible in all patients with preserved LV systolic function. In patients with AH without myocardial hypertrophy with incipient LV diastolic dysfunction increase of E/E' > or = 10 allows to suggest lowering of exercise tolerance and might be indicative of early signs of diastolic heart failure.
authors.forename: O A
authors.initials: OA
authors.lastname: Alekseeva
authors.forename: M N
authors.initials: MN
authors.lastname: Alekhin
authors.forename: B A
authors.initials: BA
authors.lastname: Sidorenko
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000502:physiology; D003971:Diastole; D018450:Disease Progression; D015150:Echocardiography, Doppler / Q000379:methods*; D005080:Exercise Test; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000502:physiology*; D015203:Reproducibility of Results; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology*