title: Adverse health effects of lead exposure on children and exploration to internal lead indicator.
abstract: Our research on adverse effects of lead exposures on physical and neurobehavioral health of children aged 6-12years in 4 villages, labeled as K, M, L, and X, in rural China, was reported in this article. Lead in blood (PbB), urine (PbU), hairs (PbH), and nails (PbN) were measured by graphite furnace atomic absorption spectrometry. Abbreviated Symptom Questionnaire of Conner's instruments and Revised Raven's Standard Progressive Matrices were applied to evaluate childhood attention deficit/hyperactivity disorders (ADHD) and intelligences. Geometric means (SD) of PbB, PbU, PbH and PbN concentrations were 71.2 microg/L (1.56), 11.7 microg/g (1.75), 12.5 microg/g (2.82), and 25.3 microg/g (2.79), respectively. 54 (17.0%) children had PbB levels of > or =100 microg/L. Boys, 6-10 years old, and living in village K were 2.11, 2.48, and 9.16 times, respectively, more likely to be poisoned by lead than girls, aged 11-12 years, and residing in X. 18 (5.7%) and 37 (11.7%) subjects had ADHD and mental retardations, respectively. Inverse relationships between intelligences and natural log transformed PbU and PbH levels were observed with respective odds ratios (95%CI) of 1.79 (1.00-3.22) and 1.46 (1.06-2.03) or 1.28 (1.04-1.58) and 1.73 (1.18-2.52) by binary or ordinal logistic regression modeling. ADHD prevalence was different by gender and age of subjects. PbU, PbH, and PbN related to PbB positively with respective correlation coefficients of 0.530, 0.477, and 0.181. Receiver operating characteristic (ROC) curves of the three measurements revealed areas under curves (AUCs) being 0.829, 0.758, and 0.687, respectively. In conclusion, children had moderate levels of lead exposures in this rural area. Intelligence declines were associated with internal lead levels among children. ROC analysis suggests PbU an internal lead indicator close to PbB.
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Q
authors.initials: Q
authors.lastname: Wang
authors.forename: H H
authors.initials: HH
authors.lastname: Zhao
authors.forename: J W
authors.initials: JW
authors.lastname: Chen
authors.forename: K D
authors.initials: KD
authors.lastname: Gu
authors.forename: Y Z
authors.initials: YZ
authors.lastname: Zhang
authors.forename: Y X
authors.initials: YX
authors.lastname: Zhu
authors.forename: Y K
authors.initials: YK
authors.lastname: Zhou
authors.forename: L X
authors.initials: LX
authors.lastname: Ye
mesh_terms: D001289:Attention Deficit Disorder with Hyperactivity / Q000523:psychology; D002648:Child; D002681:China; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D007360:Intelligence / Q000187:drug effects; D007854:Lead / Q000633:toxicity*; D008297:Male
chemical_list: D007854:Lead