title: [AQP4 expression in the brains of patients with glioblastoma and its association with brain edema].
abstract: OBJECTIVE
  To investigate the expression of aquaporin-4 (AQP4) in the brains of patients with glioblastoma and its association with brain edema.
  
  
  METHODS
  Immunofluorescence cytochemistry and western blot tests were performed to detect the expression of AQP4 in the brain tumors and the adjacent tissues in 30 patients with glioblastoma. The association between AQP4 and the extent of brain edema was analysed.
  
  
  RESULTS
  The AQP4 immunoreactive cells were mainly astrocytes in the brains, which were extensively distributed in the intracytoplasm. Higher expressions of AQP4 were found in the brain tumors and adjacent tissues in the patients with glioblastoma than in the normal controls (P<0.05). More AQP4 were distributed in the tumor adjacent tissues than in the tumors (P<0.05). The AQP4 was positively correlated with the extent of brain edema.
  
  
  CONCLUSIONS
  AQP4 overexpress in the brain tumors and adjacent tissues, which is associated with the extent of brain edema. Cytotoxic and vasogenic edemas may coexist in the cerebral edema induced by glioblastoma.
authors.affiliation: Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Ke-Jie
authors.initials: KJ
authors.lastname: Mou
authors.forename: Qing
authors.initials: Q
authors.lastname: Mao
authors.forename: Mi-Na
authors.initials: MN
authors.lastname: Chen
authors.forename: Xiao-Qiang
authors.initials: XQ
authors.lastname: Xia
authors.forename: Ren-Yong
authors.initials: RY
authors.lastname: Ni
authors.forename: Peng
authors.initials: P
authors.lastname: Wang
authors.forename: Yan-Hui
authors.initials: YH
authors.lastname: Liu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D051401:Aquaporin 4 / Q000378:metabolism*; D001921:Brain / Q000378:metabolism; D001929:Brain Edema / Q000209:etiology* / Q000378:metabolism; D001932:Brain Neoplasms / Q000150:complications / Q000378:metabolism*; D016022:Case-Control Studies; D005260:Female; D005909:Glioblastoma / Q000150:complications / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D051401:Aquaporin 4