Signs of striatal dopamine transporter density increase in association with improvement of tardive dyskinesia in a patient with schizophrenia, as demonstrated by a DAT scan.
The imaging of the dopamine transporter could demonstrate the implication of dopaminergic pathway in the appearance of tardive dyskinesia. We report a case with psychotic and tardive dyskinesia symptoms. A DAT scan showed decreased dopamine transporter uptake in the area of brain's basal gaglia. A trial with quetiapine improved both psychotic and TD symptoms while a second DAT scan showed improvement status. We conclude that increased dopamine transporter uptake seemed to associate with the improvement of TD.
Rizos
E N
EN
National and Kapodistrian University of Athens, Medical School, 2nd Department of Psychiatry, ATTIKON General Hospital, Athens, Greece. erizos@med.uoa.gr
Chatziioannou
S
S
Douzenis
A
A
Siafakas
N
N
Katsantoni
E
E
Nikolaidou
P
P
Papathanasiou
M
M
Lykouras
L
L
D000368:Aged; D014150:Antipsychotic Agents / Q000627:therapeutic use; D003342:Corpus Striatum / Q000000981:diagnostic imaging / Q000187:drug effects / Q000378:metabolism*; D003987:Dibenzothiazepines / Q000627:therapeutic use; D050483:Dopamine Plasma Membrane Transport Proteins / Q000378:metabolism*; D004409:Dyskinesia, Drug-Induced / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000378:metabolism*; D005260:Female; D006801:Humans; D000069348:Quetiapine Fumarate; D012559:Schizophrenia / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000378:metabolism*; D015899:Tomography, Emission-Computed, Single-Photon
D014150:Antipsychotic Agents; D003987:Dibenzothiazepines; D050483:Dopamine Plasma Membrane Transport Proteins; D000069348:Quetiapine Fumarate