title: Approaches for assessing risks to sensitive populations: lessons learned from evaluating risks in the pediatric population.
abstract: Assessing the risk profiles of potentially sensitive populations requires a "tool chest" of methodological approaches to adequately characterize and evaluate these populations. At present, there is an extensive body of literature on methodologies that apply to the evaluation of the pediatric population. The Health and Environmental Sciences Institute Subcommittee on Risk Assessment of Sensitive Populations evaluated key references in the area of pediatric risk to identify a spectrum of methodological approaches. These approaches are considered in this article for their potential to be extrapolated for the identification and assessment of other sensitive populations. Recommendations as to future research needs and/or alternate methodological considerations are also made.
authors.affiliation: Medical College of Wisconsin, Department of Pediatrics, Children's Research Institute, Children's Hospital and Health Systems, Milwaukee, Wisconsin 53226-4801, USA.
authors.forename: Ronald N
authors.initials: RN
authors.lastname: Hines
authors.forename: Dana
authors.initials: D
authors.lastname: Sargent
authors.forename: Herman
authors.initials: H
authors.lastname: Autrup
authors.forename: Linda S
authors.initials: LS
authors.lastname: Birnbaum
authors.forename: Robert L
authors.initials: RL
authors.lastname: Brent
authors.forename: Nancy G
authors.initials: NG
authors.lastname: Doerrer
authors.forename: Elaine A
authors.initials: EA
authors.lastname: Cohen Hubal
authors.forename: Daland R
authors.initials: DR
authors.lastname: Juberg
authors.forename: Christian
authors.initials: C
authors.lastname: Laurent
authors.forename: Robert
authors.initials: R
authors.lastname: Luebke
authors.forename: Klaus
authors.initials: K
authors.lastname: Olejniczak
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Portier
authors.forename: William
authors.initials: W
authors.lastname: Slikker
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D015415:Biomarkers / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D004781:Environmental Exposure; D004784:Environmental Monitoring; D020022:Genetic Predisposition to Disease; D033161:Government Regulation; D006291:Health Policy; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008954:Models, Biological; D010599:Pharmacokinetics; D011634:Public Health / Q000331:legislation & jurisprudence / Q000379:methods*; D018570:Risk Assessment; D012307:Risk Factors; D018675:Toxicity Tests / Q000379:methods*
chemical_list: D015415:Biomarkers