A comparison of intravenous oxycodone and intravenous morphine in patient-controlled postoperative analgesia after laparoscopic hysterectomy.
BACKGROUND
In this study, we investigated the dose requirements, pain relief, and side effects of oxycodone versus morphine after surgery with visceral pain.


METHODS
Ninety-one women received IV oxycodone or morphine before the end of laparoscopic hysterectomy and then continued with patient-controlled analgesia for 24 h postoperatively.


RESULTS
The accumulated oxycodone consumption was less (13.3 +/- 10.4 mg vs 22.0 +/- 13.1 mg, P = 0.001) than morphine. With oxycodone, the visual analog scale scores were significantly lower in the first hour postoperatively and sedation was less during the 24-h postoperative period, P = 0.006.


CONCLUSIONS
Oxycodone was more potent than morphine for visceral pain relief but not for sedation.
Lenz
Harald
H
University of Oslo, Faculty Division Ullevaal University Hospital, Oslo, Norway. harald.lenz@medisin.uio.no
Sandvik
Leiv
L
Qvigstad
Erik
E
Bjerkelund
Carl Eivind
CE
Raeder
Johan
J
D000328:Adult; D016058:Analgesia, Patient-Controlled; D000701:Analgesics, Opioid / Q000008:administration & dosage* / Q000009:adverse effects; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007044:Hysterectomy; D007275:Injections, Intravenous; D010535:Laparoscopy; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage* / Q000009:adverse effects; D010098:Oxycodone / Q000008:administration & dosage* / Q000009:adverse effects; D010147:Pain Measurement; D010149:Postoperative Pain / Q000517:prevention & control*; D012890:Sleep / Q000187:drug effects; D013997:Time Factors
D000701:Analgesics, Opioid; D009020:Morphine; D010098:Oxycodone