title: [Frequencies of the DRB1, DQA1, DQB1 and TNFA alleles in immigrant population of West Siberia].
abstract: Based on population analysis of the DRB1, DQA1, DQB1 and TNFA allele frequency distribution patterns, regional features of immunogenetic structure of the population of West Siberia were investigated. Statistically significant linkage disequilibrium within the HLA class II region, as well as between the TNFA and DRB1, DQA1, and DQB1 was demonstrated. Population frequency distribution patterns of two- and multilocus haplotypes were examined.
authors.forename: O V
authors.initials: OV
authors.lastname: Golovanova
authors.forename: V I
authors.initials: VI
authors.lastname: Konenkov
authors.forename: A V
authors.initials: AV
authors.lastname: Shevchenko
authors.forename: M V
authors.initials: MV
authors.lastname: Smol'nikova
mesh_terms: D000483:Alleles; D004641:Emigration and Immigration; D005260:Female; D005787:Gene Frequency / Q000235:genetics*; D006683:HLA-DQ Antigens / Q000235:genetics*; D059848:HLA-DQ alpha-Chains; D059866:HLA-DQ beta-Chains; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D008297:Male; D009031:Moscow; D012800:Siberia; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
chemical_list: D006683:HLA-DQ Antigens; D059848:HLA-DQ alpha-Chains; D059866:HLA-DQ beta-Chains; C069050:HLA-DQA1 antigen; C069051:HLA-DQB1 antigen; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; D014409:Tumor Necrosis Factor-alpha