title: Tumefactive intracranial presentation of precursor B-cell acute lymphoblastic leukemia.
abstract: In children, leukemia is the most common malignancy, and approximately 75% of leukemias are acute lymphoblastic leukemia (ALL). Central nervous system leukemia is found at diagnosis in fewer than 5% of children with ALL. Leukemic intracranial masses have been described with acute myeloid leukemia, but ALL presenting as a mass lesion is rare. We describe a unique case of an intracranial confirmed precursor B cell (pre-B) ALL mass in a 13-year-old girl that was diagnosed by brain CT, MRI and cerebral angiography, and confirmed by biopsy. This report details pertinent history and distinguishing imaging features of an intracranial ALL tumefaction.
authors.affiliation: University of Utah, Salt Lake City, UT, USA.
authors.forename: Craig M
authors.initials: CM
authors.lastname: Forester
authors.forename: Chi L
authors.initials: CL
authors.lastname: Braunreiter
authors.forename: Hasan
authors.initials: H
authors.lastname: Yaish
authors.forename: Gary L
authors.initials: GL
authors.lastname: Hedlund
authors.forename: Zeinab
authors.initials: Z
authors.lastname: Afify
mesh_terms: D000293:Adolescent; D001932:Brain Neoplasms / Q000175:diagnosis*; D002533:Cerebral Angiography / Q000379:methods*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis*; D014057:Tomography, X-Ray Computed / Q000379:methods*