Hair cortisol predicts object permanence performance in infant rhesus macaques (Macaca mulatta).
Although high circulating levels of glucocorticoids are associated with impaired cognitive performance in adults, less is known about this relationship in infancy. Furthermore, because studies have relied on acute cortisol measures in blood plasma or saliva, interpretation of the results may be difficult as acute measures may in part reflect emotional responses to testing procedures. In this study we examined whether hair cortisol, an integrated measure of hypothalamic-pituitary-adrenal (HPA) axis functioning, predicted performance of nursery-reared (NR) infant rhesus monkeys (n = 32) on Piagetian object permanence tasks. Testing of NR infants began at 19.8 +/- 2.2 (mean +/- SE) days of age and continued for the next several months. Hair cortisol concentrations from the 32 NR monkeys were compared to those of 20 mother-peer-reared (MPR) infants. Hair was shaved at Day 14, allowed to regrow, and obtained again at month 6, thus representing integrated cortisol over a 5.5-month period of time. NR and MPR infants did not differ in month 6 hair cortisol values (t((50)) = 0.02, p = 0.98). Linear regression revealed that hair cortisol predicted object permanence performance in the NR infants. Infants with higher hair cortisol reached criterion at later ages on the well (p < 0.01), screen (p < 0.05), and A-not-B (p < 0.05) tasks and required more test sessions to complete the well (p < 0.01) and screen tasks (p < 0.05). These data are the first to implicate hair cortisol as a reliable predictor of early cognitive performance in infant macaque monkeys.
Dettmer
Amanda M
AM
Neuroscience and Behavior Program, University of Massachusetts, Tobin Hall, 135 Hicks Way, Amherst, MA 01003, USA. adettmer@nsm.umass.edu
Novak
Matthew F S X
MF
Novak
Melinda A
MA
Meyer
Jerrold S
JS
Suomi
Stephen J
SJ
D000818:Animals; D000831:Animals, Newborn; D001288:Attention / Q000502:physiology; D001522:Behavior, Animal; D003210:Concept Formation / Q000502:physiology*; D005260:Female; D006197:Hair / Q000737:chemistry*; D006854:Hydrocortisone / Q000032:analysis*; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology*; D008253:Macaca mulatta; D008297:Male; D011939:Mental Recall / Q000502:physiology; D010913:Pituitary-Adrenal System / Q000502:physiology*; D011237:Predictive Value of Tests; D012044:Regression Analysis; D014796:Visual Perception / Q000502:physiology
D006854:Hydrocortisone