title: Modified animal model and computer-assisted approach for dentoalveolar distraction osteogenesis to reconstruct unilateral maxillectomy defect.
abstract: OBJECTIVE
  The purpose of this report is to show the establishment of an animal model with a unilateral maxilla defect, application of virtual reality and rapid prototyping in the surgical planning for dentoalveolar distraction osteogenesis (DO).
  
  
  METHODS
  Two adult dogs were used to develop an animal model with a unilateral maxillary defect. The 3-dimensional model of the canine craniofacial skeleton was reconstructed with computed tomography data using the software Mimics, version 12.0 (Materialise Group, Leuven, Belgium). A virtual individual distractor was designed and transferred onto the model with the defect, and the osteotomies and distraction processes were simulated. A precise casting technique and numeric control technology were applied to produce the titanium distraction device, which was installed on the physical model with the defect, which was generated using Selective Laser Sintering technology, and the in vitro simulation of osteotomies and DO was done.
  
  
  RESULTS
  The 2 dogs survived the operation and were lively. The osteotomies and distraction process were simulated successfully whether on the virtual or the physical model. The bone transport could be distracted to the desired position both in the virtual environment and on the physical model.
  
  
  CONCLUSIONS
  The novel method to develop an animal model with a unilateral maxillary defect was feasible, and the animal model was suitable to develop the reconstruction method for unilateral maxillary defect cases with dentoalveolar DO. Computer-assisted surgical planning and simulation improved the reliability of the maxillofacial surgery, especially for the complex cases. The novel idea to reconstruct the unilateral maxillary defect with dentoalveolar DO was proved through the model experiment.
authors.affiliation: Department of Prosthodontics, Fourth Military Medical University School of Stomatology, Shaanxi, China.
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Feng
authors.forename: Jinlong
authors.initials: J
authors.lastname: Zhao
authors.forename: Libin
authors.initials: L
authors.lastname: Zhou
authors.forename: Yan
authors.initials: Y
authors.lastname: Dong
authors.forename: Yimin
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D000818:Animals; D003198:Computer Simulation; D017076:Computer-Aided Design; D004195:Disease Models, Animal; D004285:Dogs; D004867:Equipment Design; D005240:Feasibility Studies; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D008437:Maxilla / Q000601:surgery*; D008439:Maxillary Diseases / Q000601:surgery; D008953:Models, Anatomic; D019857:Osteogenesis, Distraction / Q000295:instrumentation / Q000379:methods*; D010027:Osteotomy; D010347:Patient Care Planning; D025321:Surgery, Computer-Assisted / Q000379:methods*; D014025:Titanium; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014584:User-Computer Interface
chemical_list: D014025:Titanium