title: A washout period needed before switching from a neuroleptic to an amphetamine.
abstract: (1) Abrupt replacement of risperidone with methylphenidate can lead to severe agitation in children; (2) Abruptly switching from one pharmacological class to another can lead to complications.
mesh_terms: D000293:Adolescent; D000662:Amphetamines / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy; D002648:Child; D004347:Drug Interactions; D006801:Humans; D008774:Methylphenidate / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D011595:Psychomotor Agitation; D018967:Risperidone / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000662:Amphetamines; D014150:Antipsychotic Agents; D008774:Methylphenidate; D018967:Risperidone