Synthesis of 5'-fluoro-2'-beta-methylneplanocin analogues.
Synthesis of 5'-fluoro-2'-beta-methylneplanocin analogues (5) was carried out. The cyclopentenone 16 was prepared from methyl mannopyranoside by using ring closing metathesis, stereoselective introduction of methyl group, and seleno cyclization as representative steps. Introduction of a fluorine atom was conducted by electrophilic fluorination. Antiviral activity of 5 will also be presented.
Kumamoto
Hiroki
H
School of Pharmaceutical Sciences, Showa University, Tokyo 142-8555, Japan. kumamoto@pharm.showa-u.ac.jp
Kobayashi
Marina
M
Tanaka
Hiromichi
H
D000241:Adenosine / Q000031:analogs & derivatives*; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D054879:Halogenation
D000998:Antiviral Agents; D000241:Adenosine