Successful radiation therapy for supratentorial primitive neuroectodermal tumor and epidermolysis bullosa simplex.
Epidermolysis bullosa simplex (EBS) is a heritable skin disorder characterized by skin fragility and blistering. While its most severe variant, dystrophic epidermolysis bullosa (DEB) is associated with squamous cell carcinoma (SCC), the development of extracutaneous neoplasms in EBS is extremely rare. We report a novel case of supratentorial primitive neuroectodermal tumor (sPNET) in a 7-year male with EBS. Experience of radiation therapy and its challenges in children with EBS has rarely been reported.
Bavishi
Sejal
S
Department of Radiation Oncology, Childrens Hospital Los Angeles, Los Angeles, California, USA.
Wong
Kenneth
K
Delgardo
Thamani
T
Marachelian
Araz
A
Khatua
Soumen
S
D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000532:radiotherapy*; D002648:Child; D016110:Epidermolysis Bullosa Simplex / Q000473:pathology / Q000532:radiotherapy*; D005240:Feasibility Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D018242:Neuroectodermal Tumors, Primitive / Q000473:pathology / Q000532:radiotherapy*; D012878:Skin Neoplasms / Q000473:pathology / Q000532:radiotherapy*