[Expression and significance of VCAM-1 in subjects with allergic inflammation of respiratory tract].
OBJECTIVE
To study the expression and significance of vascular cell adhesion molecule-1 (VCAM-1) in subjects with allergic inflammation of respiratory tract.


METHODS
Thirty-nine subjects with allergic rhinitis and asthma (allergic rhinitis and asthma group) and twenty-one subjects with only allergic rhinitis (allergic rhinitis group) were divided into two group. Bronchial and nasal biopsy specimens were taken and were stained with HE. The expression of VCAM-1 in nasal and bronchial mucosa was detected by immunohistochemistry technique.


RESULTS
The amounts of eosinophils within bronchial mucosa of allergic rhinitis and asthma group were significantly higher than that of allergic rhinitis group (t=12.81, P<0.01). The difference of VCAM-1 expression between allergic rhinitis group and allergic rhinitis and asthma group was not statistically significant . The amounts of VCAM-1 positive cell in bronchial mucosa of allergic rhinitis and asthma group were significantly higher than that of allergic rhinitis group (t=9.43, P<0.01). The number of VCAM-1 positive cells in bronchial mucosa was significantly positively correlated with the number of eosinophils in bronchial mucosa of allergic rhinitis and asthma group (r=0.783, P<0.01).


CONCLUSIONS
This study shows that upregulation of VCAM results in generalized airway inflammation in patients with allergic rhinitis.
Wang
Yuanyuan
Y
Department of Otorhinolaryngology, Huaihe Hospital of Henan University, Kaifeng, 475000, China. zmh0334@yahoo.com.cn
Zhou
Minghui
M
Lou
Weihua
W
D000328:Adult; D001249:Asthma / Q000150:complications / Q000378:metabolism*; D005260:Female; D006801:Humans; D007249:Inflammation; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000378:metabolism*; D012220:Rhinitis / Q000150:complications / Q000378:metabolism*; D019010:Vascular Cell Adhesion Molecule-1 / Q000378:metabolism*
D019010:Vascular Cell Adhesion Molecule-1