Treatment of venous thromboembolism in patients with cancer: Guidelines of the Italian Society for Haemostasis and Thrombosis (SISET).
BACKGROUND
The treatment of venous thromboembolism (VTE) in cancer patients remains controversial.


OBJECTIVE
The Italian Society for Thrombosis and Haemostasis (SISET) commissioned a project to develop clinical practice guidelines for the therapy of VTE in patients with malignancies.


METHODS
Key questions about the treatment of VTE in patients with malignancies were formulated by a multidisciplinary working group consisting of experts in clinical medicine and research. After a systematic review and discussion of the literature, recommendations were formulated and graded according to the supporting evidence. For those questions for which the literature search did not yield any definitive answer (absence of evidence evidence of low quality, and contradictory evidence), a formal consensus method was used to issue clinical recommendations.


RESULTS
The results of the available literature on VTE treatment in cancer patients were reviewed and clinical recommendations were drafted.


CONCLUSIONS
We describe the results of a systematic literature review and an explicit approach to consensus techniques which resulted in recommendations for the key therapeutic issues in cancer patients with VTE.
Imberti
Davide
D
Emergency Department, Piacenza Hospital, Italy. d.imberti@ausl.pc.it
Di Nisio
Marcello
M
Donati
Maria Benedetta
MB
Falanga
Anna
A
Ghirarduzzi
Angelo
A
Guarneri
Daniele
D
Piovella
Franco
F
Santoro
Rita Carlotta
RC
Baldini
Edoardo
E
Zampogna
Stefania
S
D006801:Humans; D007558:Italy; D009369:Neoplasms / Q000097:blood / Q000150:complications*; D016896:Treatment Outcome; D054556:Venous Thromboembolism / Q000150:complications* / Q000628:therapy*