[Protective effect of 3'-methoxy puerarin on cerebral ischemic injury/ reperfusion in rats].
OBJECTIVE
To observe the effect of 3'-methoxy puerarin on cerebral infarction volume and free radical change of focal cerebral ischemia-reperfusion injury in rats and discuss the protective effect of 3'-methoxy puerarin on the cerebral ischemic/ reperfusion injury.


METHODS
The thread method was used to induce middle cerebral artery embolization, to establish the focal cerebral ischemia-reperfusion model. Rats were divided into five groups: the sham and model group, the two-dose group (5, 10 mg x kg(-1) x d(-1)) of 3'-methoxy puerarin and nimodipine group (5 mg x kg(-1) x d(-1)). The behavior changes and volume of cerebral infarction were observed, and the leves of SOD and the content of MDA were measured.


RESULTS
3'-methoxy puerarin could significantly improve the symptoms of neurological deficit and reduce the infarct volume, and increased SOD activity and reduced the content of MDA of cortex in cerebral ischemia-reperfusion injury rat, the action of 10 mg x kg(-1) of 3'-methoxy puerarin is more remarkable.


CONCLUSIONS
3'-methoxy puerarin has protective effect on focal cerebral ischemia-reperfusion injury in rat.
Han
Jin
J
Traditional Chinese Medicine University of Zhejiang, Institute of Cardio-Cerebrovascular Diseases, Hangzhou 310053, China.
Wan
Haitong
H
Ge
Lijun
L
Zhu
Zhenhong
Z
Guo
Ying
Y
Zhang
Yuyan
Y
Li
Jinhui
J
D000818:Animals; D002545:Brain Ischemia / Q000188:drug therapy / Q000517:prevention & control*; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D007529:Isoflavones / Q000494:pharmacology*; D008297:Male; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000188:drug therapy / Q000517:prevention & control*
D007529:Isoflavones; C033607:puerarin