title: Factor XIIIa+ dermal dendrocyte parasitism in American tegumentary leishmaniasis skin lesions.
abstract: Dendritic cells belong to a family of antigen-presenting cells that are localized at the entry sites, such as skin and mucosa. Dendritic cells are related to immune surveillance function. The role of Langerhans cells in the pathogenesis of skin infectious diseases is well studied; however, there are few articles addressing involvement of factor XIIIa-positive dermal dendrocytes (FXIIIa+ DD) in such processes. FXIIIa+ DDs are bone marrow-monocytic lineage-derived cells and members of the skin immune system. Due to their immune phenotype and functional characteristics, they are considered complementary cells to Langerhans cells in the process of antigen presentation and inducing immune response. To verify the interaction between FXIIIa+ DD and Leishmania amastigotes, 22 biopsies of American tegumentary leishmaniasis (ATL) skin lesions were subjected to double staining technique with anti-factor XIIIa and anti-Leishmania antibodies. FXIIIa+ DDs were hypertrophic and abundant in the cutaneous reaction of ATL. FXIIIa+ DDs harboring parasites were observed in 11 of 22 skin biopsies. The data obtained suggest that FXIIIa+ DD plays a role in the pathogenesis of ATL skin lesion as host cell, immune effector, and/or antigen-presenting cell.
authors.affiliation: Departments of Dermatology, University of São Paulo Medical School, São Paulo, Brazil. mnsotto@usp.br
authors.forename: Mírian N
authors.initials: MN
authors.lastname: Sotto
authors.forename: Ilana
authors.initials: I
authors.lastname: Halpern
authors.forename: Monica Rebeca
authors.initials: MR
authors.lastname: Kauffman
authors.forename: Carla
authors.initials: C
authors.lastname: Pagliari
mesh_terms: D015415:Biomarkers / Q000378:metabolism*; D003713:Dendritic Cells / Q000201:enzymology*; D020405:Dermis / Q000201:enzymology* / Q000473:pathology; D026122:Factor XIIIa / Q000378:metabolism*; D006099:Granuloma / Q000201:enzymology / Q000469:parasitology / Q000473:pathology; D006790:Host-Parasite Interactions; D006801:Humans; D007124:Immunoenzyme Techniques; D007891:Leishmania / Q000302:isolation & purification / Q000502:physiology; D016773:Leishmaniasis, Cutaneous / Q000201:enzymology* / Q000473:pathology
chemical_list: D015415:Biomarkers; D026122:Factor XIIIa