Homophymines B-E and A1-E1, a family of bioactive cyclodepsipeptides from the sponge Homophymia sp.
Nine new cyclodepsipeptides, homophymines B-E (2-5) and A1-E1 (1a-5a), were isolated from the polar extracts of the sponge Homophymia sp. The new structures, featuring new polyketide-derived end groups, were determined by interpretation of NMR and MS data. The configurations of the new end groups was secured by the application of J-based configurational analysis. Homophymines displayed very potent antiproliferative activity (IC(50) in the nM range) against a panel of human cancer cell lines.
Zampella
Angela
A
Dipartimento di Chimica delle Sostanze Naturali, Università di Napoli Federico II, via D. Montesano 49, 80131, Napoli, Italy.
Sepe
Valentina
V
Bellotta
Filomena
F
Luciano
Paolo
P
D'Auria
Maria Valeria
MV
Cresteil
Thierry
T
Debitus
Cécile
C
Petek
Sylvain
S
Poupat
Christiane
C
Ahond
Alain
A
D000818:Animals; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D047630:Depsipeptides / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D011161:Porifera / Q000737:chemistry*
D047630:Depsipeptides