title: Immunohistochemical findings of multiple ossified en plaque meningiomas in the thoracic spine.
abstract: We describe a 76-year-old woman who presented with painful muscle weakness and numbness in both legs secondary to grossly ossified meningiomas at the T8 and T11-T12 vertebral levels. Midline durotomy followed by en bloc excision of the tumours, together with partial resection of the dura mater and the arachnoid, was performed. Histopathological examination showed both tumours consisted of three different histological patterns: psammomatous, fibrous, and metaplastic subtypes. Immunostaining for bone morphogenetic protein-2 and vascular endothelial growth factor was significantly positive in the areas surrounding mature bone tissues in the metaplastic and psammomatous subtypes.
authors.affiliation: Department of Orthopaedics and Rehabilitation Medicine, Fukui University, Faculty of Medical Sciences, Matsuoka Shimoaizuki 23, Eiheiji, Fukui 910-1193, Japan. kuchida@u-fukui.ac.jp
authors.forename: Kenzo
authors.initials: K
authors.lastname: Uchida
authors.forename: Hideaki
authors.initials: H
authors.lastname: Nakajima
authors.forename: Takafumi
authors.initials: T
authors.lastname: Yayama
authors.forename: Ryuichiro
authors.initials: R
authors.lastname: Sato
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kobayashi
authors.forename: Erisa S
authors.initials: ES
authors.lastname: Mwaka
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Imamura
authors.forename: Hisatoshi
authors.initials: H
authors.lastname: Baba
mesh_terms: D000368:Aged; D055396:Bone Morphogenetic Protein 2 / Q000378:metabolism; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008577:Meningeal Neoplasms / Q000150:complications / Q000378:metabolism*; D008579:Meningioma / Q000150:complications / Q000378:metabolism*; D018396:Mucin-1 / Q000378:metabolism; D009999:Ossification, Heterotopic / Q000209:etiology / Q000378:metabolism*; D013904:Thoracic Vertebrae / Q000473:pathology; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism; D014746:Vimentin / Q000378:metabolism
chemical_list: C525718:BMP2 protein, human; D055396:Bone Morphogenetic Protein 2; D018396:Mucin-1; D042461:Vascular Endothelial Growth Factor A; D014746:Vimentin