Linkage between immunomodulation, neuroprotection and neurogenesis.
Neuronal protection and restoration are the major goals for the therapy of neurodegenerative diseases, representing a very active field of research. In multiple sclerosis, treatments need to target both the autoimmune inflammation and the pathological neurodegeneration. The optimal therapeutic approach may promote remyelination and axonal repair, and even lead to neuronal renewal. This review article will discuss both endogenous neuroprotective mechanisms and those triggered by potential therapies. Currently employed immunomodulatory treatments and their ability to induce neuroprotection, tissue repair and neurogenesis are also presented.
Aharoni
Rina
R
Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel.
Arnon
Ruth
R
D000818:Animals; D006801:Humans; D007155:Immunologic Factors / Q000494:pharmacology* / Q000627:therapeutic use; D009103:Multiple Sclerosis / Q000188:drug therapy* / Q000276:immunology; D009410:Nerve Degeneration / Q000188:drug therapy; D019636:Neurodegenerative Diseases / Q000188:drug therapy / Q000276:immunology; D055495:Neurogenesis / Q000187:drug effects; D018696:Neuroprotective Agents / Q000276:immunology / Q000494:pharmacology* / Q000627:therapeutic use
D007155:Immunologic Factors; D018696:Neuroprotective Agents