title: What have we learned about bipolar disorder from STEP-BD and other practical trials?
abstract: Certain developments are informing the treatment of patients with bipolar disorder. Results from the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD) study and other pragmatic clinical trials are providing practical information on relapse/recurrence, comorbidities, and pharmacologic and psychosocial treatment. Also, the Bipolar Trials Network (BTN) has been established to provide an infrastructure for National Institutes of Health (NIH) and trials with high public health significance. More research is needed to explore fundamental questions about bipolar disorder and its treatment.
authors.affiliation: Bipolar Clinic and Research Program, Massachusetts General Hospital, Boston, USA.
authors.forename: Andrew A
authors.initials: AA
authors.lastname: Nierenberg
mesh_terms: D001714:Bipolar Disorder / Q000628:therapy*; D002908:Chronic Disease; D006801:Humans; D009316:National Institutes of Health (U.S.) / Q000706:statistics & numerical data; D010347:Patient Care Planning; D040442:Public Health Informatics / Q000706:statistics & numerical data; D016032:Randomized Controlled Trials as Topic / Q000706:statistics & numerical data*; D012106:Research; D055502:Secondary Prevention; D014481:United States