Similarities in features of autism and asthma and a possible link to acetaminophen use.
Autism and autism spectrum disorders are enigmatic conditions that have their origins in the interaction of genes and environmental factors. In this hypothesis, genes statistically associated with autism are emphasized to be important in inflammation and in innate immune pathways, including pathways for susceptibility to asthma. The role of acetaminophen (paracetamol) in an increased risk for asthma is described and a possible similar link to an increased risk for autism is suggested.
Becker
Kevin G
KG
Schultz
Stephen T
ST
D000082:Acetaminophen / Q000009:adverse effects*; D000293:Adolescent; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D001249:Asthma / Q000139:chemically induced / Q000175:diagnosis*; D001321:Autistic Disorder / Q000139:chemically induced / Q000175:diagnosis*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007113:Immunity, Innate; D007223:Infant; D007231:Infant, Newborn; D008264:Macrophages / Q000378:metabolism; D008407:Mast Cells / Q000378:metabolism; D008954:Models, Biological; D008962:Models, Theoretical
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000082:Acetaminophen