title: Synthesis and thermal denaturation studies of covalently linked DNA triplexes.
abstract: We report on the synthesis and thermal stability of small covalently linked DNA triplexes. These modified triplexes were found to contain covalently linked T-T pairs at the edges, and thermal denaturation studies revealed that the covalent linking efficiently stabilized triplex formation.
authors.affiliation: Department of Material and Life Chemistry, Faculty of Engineering, Kanagawa University, Yokohama 221-8686, Japan.
authors.forename: Itaru
authors.initials: I
authors.lastname: Okamoto
authors.forename: Shota
authors.initials: S
authors.lastname: Ito
authors.forename: Takashi
authors.initials: T
authors.lastname: Ono
authors.forename: Akira
authors.initials: A
authors.lastname: Ono
mesh_terms: D004247:DNA / Q000138:chemical synthesis / Q000737:chemistry*; D009691:Nucleic Acid Denaturation; D009838:Oligodeoxyribonucleotides / Q000737:chemistry; D013816:Thermodynamics
chemical_list: D009838:Oligodeoxyribonucleotides; C051802:triplex DNA; D004247:DNA