title: Age-specific breast, uterine and ovarian cancer mortality trends in Spain: changes from 1980 to 2006.
abstract: BACKGROUND
  Cancers of the breast, uterus and ovary are responsible for 30% of the cancer deaths in Spanish women. In recent decades, Spain has experienced important socioeconomic transformations, which may have affected mortality trends. We present the current situation of mortality in Spain due to cancers of the breast, uterus and ovary, as well as trends over 1980-2006.
  
  
  METHODS
  Data on population and deaths due to cancers of the breast, uterus and ovary were obtained from records of the National Statistics Institute. Overall and age-specific changes in mortality of these tumors were studied using change-point Poisson regression models.
  
  
  RESULTS
  Breast cancer was responsible for more than 140,000 deaths of females in 1980-2006. Trend analysis of breast cancer mortality of women of all ages showed that rates increased 2.9% annually until 1992 (95% confidence interval (CI)=2.5, 3.3). After 1992, mortality declined steadily at a rate of -2.1% per year (95% CI=-2.4, -1.8). The number of deaths due to cancers of the uterus was 49,287 between the years 1980 and 2006. Uterine cancer mortality registered a steady decrease of -1.9% every year since 1980 (95% CI=-2.1, -1.8). Ovarian cancer caused 36,157 deaths during the same period, with rates in women older than 50 years more than ten-fold those of younger women. Trend analysis showed a sharp increase of mortality up to 1998 (4.4% annually; 95% CI=3.9, 4.8) followed by a stabilization.
  
  
  CONCLUSIONS
  The downturn observed in mortality for these tumors mainly reflects improved survival as a result of earlier diagnosis and better cancer treatments. Cancer management is moving in the right direction in Spain.
authors.affiliation: Area de Epidemiología Ambiental y Cáncer, Centro Nacional de Epidemiología, Instituto de Salud Carlos III, 28029 Madrid, Spain. acabanes@isciii.es
authors.forename: Anna
authors.initials: A
authors.lastname: Cabanes
authors.forename: Enrique
authors.initials: E
authors.lastname: Vidal
authors.forename: Beatriz
authors.initials: B
authors.lastname: Pérez-Gómez
authors.forename: Nuria
authors.initials: N
authors.lastname: Aragonés
authors.forename: Gonzalo
authors.initials: G
authors.lastname: López-Abente
authors.forename: Marina
authors.initials: M
authors.lastname: Pollán
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D001943:Breast Neoplasms / Q000175:diagnosis / Q000401:mortality* / Q000628:therapy; D005260:Female; D006801:Humans; D008403:Mass Screening; D008875:Middle Aged; D009026:Mortality / Q000639:trends; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000401:mortality* / Q000628:therapy; D016012:Poisson Distribution; D012959:Socioeconomic Factors; D013030:Spain / Q000453:epidemiology; D014594:Uterine Neoplasms / Q000175:diagnosis / Q000401:mortality* / Q000628:therapy; D055815:Young Adult