[Effect of geniposide on vascular dementia in rats].
OBJECTIVE
To investigate the effect of geniposide on vascular dementia (VaD) in rats.


METHODS
VaD rat model was established by permanent ligation of bilateral common carotid arteries. Morris water maze performance was assessed after 4 weeks of treatment with geniposide, followed by pathological examinations of hippocampus and cerebral cortex.


RESULTS
The VaD rats had significantly longer escape latency and lower percentage of activities in platform quadrant than the rats in the sham surgery group (P<0.05). The VaD rats treated with geniposide [50 mg/(kg x d), 75 mg/(kg x d)] had significantly shorter escape latency (except the first day of the test) and significantly higher percentage of activities in platform quadrant than the VaD rats without treatment (P<0.05). No significant differences were found between the geniposide treated group and the Donepezil treated group and the sham surgery control group. Geniposide significantly alleviated neurons,apoptosis and necrosis induced by chronic cerebral hypoperfusion of cortex and hippocampus.


CONCLUSIONS
Chronic cerebral hypoperfusion can induce cognitive impairment. Geniposide can improve cognitive ability of Vascular Dementia in rats. This may represent a potential treatment strategy for vascular dementia.
Li
Li-Juan
LJ
Department of Neurology, West China Hospital, Sichuan University, Chengdu 610041, China.
Li
Hong-Xia
HX
Wu
Xin-Tong
XT
Yan
Bo
B
Zhou
Dong
D
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D003071:Cognition / Q000187:drug effects; D015140:Dementia, Vascular / Q000188:drug therapy* / Q000473:pathology; D006624:Hippocampus / Q000473:pathology*; D039823:Iridoids / Q000627:therapeutic use*; D008297:Male; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
D039823:Iridoids; C007835:geniposide