Telomere biology in healthy aging and disease.
Aging is a biological process that affects most cells, organisms and species. Telomeres have been postulated as a universal biological clock that shortens in parallel with aging in cells. Telomeres are located at the end of the chromosomes and consist of an evolutionary conserved repetitive nucleotide sequence ranging in length from a few hundred base pairs in yeast till several kilo base pairs in vertebrates. Telomeres associate with shelterin proteins and form a complex protecting the chromosomal deoxyribonucleic acid (DNA) from recognition by the DNA damage-repair system. Due to the "end-replication problem" telomeres shorten with each mitotic cycle resulting in cumulative telomere attrition during aging. When telomeres reach a critical length the cell will not further undergo cell divisions and become senescent or otherwise dysfunctional. Telomere shortening has not only been linked to aging but also to several age associated diseases, including tumorigenesis, coronary artery disease, and heart failure. In the current review, we will discuss the role of telomere biology in relation to aging and aging associated diseases.
Oeseburg
Hisko
H
Department of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700RB Groningen, The Netherlands.
de Boer
Rudolf A
RA
van Gilst
Wiek H
WH
van der Harst
Pim
P
D000375:Aging / Q000235:genetics*; D019588:Aging, Premature / Q000235:genetics; D000818:Animals; D050197:Atherosclerosis / Q000235:genetics; D002318:Cardiovascular Diseases / Q000235:genetics*; D016922:Cellular Senescence / Q000235:genetics*; D003324:Coronary Artery Disease / Q000235:genetics; D006333:Heart Failure / Q000235:genetics; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D012307:Risk Factors; D016615:Telomere / Q000502:physiology*