title: Bevacizumab induced reversible thrombocytopenia in a patient with recurrent high-grade glioma: a case report.
abstract: We report a case of bevacizumab (BEV)-induced thrombocytopenia in a 36-year-old woman treated with BEV as a single-agent for a recurrent high-grade glioma. The thrombocytopenia was both reversible and reproducible on multiple treatment cycles. The patient has improved clinically and by brain MR imaging with single-agent BEV for approximately 7 months to date. She did not have bleeding or thromboembolic complications. Treatment delays have been 1-2 weeks relative to a conventional plan of treatment, i.e., 10 mg/kg every 2 weeks. This is a rare complication that has not been previously reported.
authors.affiliation: Paul P. Carbone Comprehensive Cancer Center, University of Wisconsin, Madison, 53706, USA.
authors.forename: Ticiana
authors.initials: T
authors.lastname: Leal
authors.forename: H Ian
authors.initials: HI
authors.lastname: Robins
mesh_terms: D000328:Adult; D020533:Angiogenesis Inhibitors / Q000009:adverse effects*; D000911:Antibodies, Monoclonal / Q000009:adverse effects*; D061067:Antibodies, Monoclonal, Humanized; D001254:Astrocytoma / Q000188:drug therapy*; D000068258:Bevacizumab; D001932:Brain Neoplasms / Q000188:drug therapy*; D005260:Female; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy; D013921:Thrombocytopenia / Q000139:chemically induced*
chemical_list: D020533:Angiogenesis Inhibitors; D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D000068258:Bevacizumab