Imidazole-based phosphane gold(I) complexes as potential agents for cancer treatment: synthesis, structural studies and antitumour activity.
The reaction of the imidazolyl-4(5)-phosphane ligands 2-isopropylimidazol-4(5)yl-diphenylphosphane (4-MIP(iPr)) and tris(2-isopropylimidazol-4(5)yl)phosphane (4-TIP(iPr)) towards gold(I) has been explored and compared to those of analogous 1-methylimidazol-2-ylphosphane ligands. The structure of [(4-MIP(iPr))AuCl] () shows a linear P-Au-Cl coordination, whereas the 4-TIP(iPr) ligand forms a dinuclear complex [{(4-TIP(iPr))Au}(2)]Cl(2) (). Here, 4-TIP(iPr) bridges two gold(I) atoms in a head-to-tail P,N fashion. Complex forms in the presence of the hard Lewis acid ZnCl(2) the bimetallic complex [AuCl(4-TIP(iPr))ZnCl]Cl (), in which 4-TIP(iPr) bridges the two metal centers. In accordance with the HSAB concept the Au(I) atom is coordinated by the P atom and the zinc(II) by three N atoms in a N,N,N fashion. The solid-state structures of the complexes have been elucidated by single-crystal X-ray analysis. The Au(I)-Au(I) contact in is 2.8821(15) A. The biological activities of all imidazol-2-yl- and imidazol-4(5)-ylphosphane gold(I) complexes towards nine human cancer cell lines including seven ovarian cancer cell lines of different sensitivity towards cisplatin and two leukemia cell lines have been explored.
Kunz
Peter C
PC
Institut für Anorganische Chemie und Strukturchemie, Heinrich-Heine-University Düsseldorf, Universitätsstr. 1, D-40225, Düsseldorf, Germany. peter.kunz@uni-duesseldorf.de
Kassack
Matthias U
MU
Hamacher
Alexandra
A
Spingler
Bernhard
B
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D017612:Gold Compounds / Q000737:chemistry; D006801:Humans; D007093:Imidazoles / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D008958:Models, Molecular; D008968:Molecular Conformation; D050607:Organogold Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D010720:Phosphines / Q000737:chemistry*; D012995:Solubility; D014867:Water / Q000737:chemistry
D000970:Antineoplastic Agents; D017612:Gold Compounds; D007093:Imidazoles; D050607:Organogold Compounds; D010720:Phosphines; D014867:Water; C038016:gold chloride; C029899:imidazole; C044646:phosphine