Oral manifestations of vitamin B12 deficiency: a case report.
Megaloblastic anemias are a subgroup of macrocytic anemias, in which distinctive morphologic abnormalities occur in red cell precursors in bone marrow, namely megaloblastic erythropoiesis. Of the many causes of megaloblastic anemia, the most common are disorders resulting from cobalamin or folate deficiency. The clinical symptoms are weakness, fatigue, shortness of breath and neurologic abnormalities. The presence of oral signs and symptoms, including glossitis, angular cheilitis, recurrent oral ulcer, oral candidiasis, diffuse erythematous mucositis and pale oral mucosa offer the dentist an opportunity to participate in the diagnosis of this condition. Early diagnosis is important to prevent neurologic signs, which could be irreversible. The aim of this paper is to describe the oral changes in a patient with megaloblastic anemia caused by a dietary deficiency of cobalamin.
Pontes
Hélder Antônio Rebelo
HA
Dental School of the Federal University of Pará, Pará, Brazil.
Neto
Nicolau Conte
NC
Ferreira
Karen Bechara
KB
Fonseca
Felipe Paiva
FP
Vallinoto
Gizelle Monteiro
GM
Pontes
Flávia Sirotheau Corrêa
FS
Pinto
Décio dos Santos
Ddos S
D000328:Adult; D000749:Anemia, Megaloblastic / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D005260:Female; D006801:Humans; D006879:Hydroxocobalamin / Q000627:therapeutic use; D009059:Mouth Diseases / Q000175:diagnosis / Q000209:etiology*; D016896:Treatment Outcome; D014805:Vitamin B 12 / Q000627:therapeutic use; D014806:Vitamin B 12 Deficiency / Q000150:complications / Q000175:diagnosis*; D014803:Vitamin B Complex / Q000627:therapeutic use
D014803:Vitamin B Complex; D014805:Vitamin B 12; D006879:Hydroxocobalamin