Isolation and structural elucidation of euryjanicins B-D, proline-containing cycloheptapeptides from the Caribbean marine sponge Prosuberites laughlini.
Three new cyclic peptides, euryjanicins B (2), C (3), and D (4), have been isolated from the Puerto Rican marine sponge Prosuberites laughlini, and the structures were elucidated by chemical degradation, ESIMS/MS, and extensive 2D NMR methods. When tested against the National Cancer Institute 60 tumor cell line panel, all of the purified isolates displayed weak cytotoxicity.
Vera
Brunilda
B
Department of Chemistry, University of Puerto Rico, U. P. R. Station, San Juan, PR 00931-3346.
Vicente
Jan
J
Rodríguez
Abimael D
AD
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D017691:Caribbean Region; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011161:Porifera / Q000737:chemistry*; D011392:Proline / Q000737:chemistry
D000970:Antineoplastic Agents; D010456:Peptides, Cyclic; C544234:euryjanicin B; C544235:euryjanicin C; C544236:euryjanicin D; D011392:Proline