Dividing the goods: co-ordination of chromosome biorientation and mitotic checkpoint signalling by mitotic kinases.
Error-free chromosome segregation during cell division relies on chromosome biorientation and mitotic checkpoint activity. A group of unrelated kinases controls various aspects of both processes. The present short review outlines our current understanding of the roles of these kinases in maintaining chromosomal stability.
Kops
Geert J P L
GJ
Department of Physiological Chemistry and Cancer Genomics Centre, UMC Utrecht, Utrecht, The Netherlands. g.j.p.l.kops@umcutrecht.nl
D018797:Cell Cycle Proteins / Q000378:metabolism*; D045584:Chromosome Positioning; D020090:Chromosome Segregation; D006801:Humans; D018386:Kinetochores / Q000378:metabolism; D008938:Mitosis / Q000502:physiology*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D008941:Spindle Apparatus / Q000378:metabolism*
D018797:Cell Cycle Proteins; D017346:Protein Serine-Threonine Kinases