title: Chronic haemolytic anaemia because of pyruvate kinase (PK) deficiency in a child heterozygous for haemoglobin S and no clinical features of sickle cell disease.
authors.forename: Licínio
authors.initials: L
authors.lastname: Manco
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Vagace
authors.forename: Luís
authors.initials: L
authors.lastname: Relvas
authors.forename: Umbelina
authors.initials: U
authors.lastname: Rebelo
authors.forename: Celeste
authors.initials: C
authors.lastname: Bento
authors.forename: Ana
authors.initials: A
authors.lastname: Villegas
authors.forename: Maria
authors.initials: M
authors.lastname: Letícia Ribeiro
mesh_terms: D000328:Adult; D000746:Anemia, Hemolytic, Congenital Nonspherocytic / Q000097:blood / Q000150:complications / Q000235:genetics*; D002648:Child; D004909:Erythrocyte Indices; D005260:Female; D006451:Hemoglobin, Sickle / Q000378:metabolism; D006579:Heterozygote; D006801:Humans; D008297:Male; D020125:Mutation, Missense; D010100:Oxygen / Q000097:blood; D010641:Phenotype; D017354:Point Mutation; D011770:Pyruvate Kinase / Q000172:deficiency* / Q000235:genetics; D015323:Pyruvate Metabolism, Inborn Errors / Q000097:blood / Q000201:enzymology / Q000235:genetics*; D012805:Sickle Cell Trait / Q000097:blood / Q000150:complications / Q000235:genetics*; D055544:beta-Globins / Q000235:genetics
chemical_list: D006451:Hemoglobin, Sickle; D055544:beta-Globins; D011770:Pyruvate Kinase; D010100:Oxygen