Peruvian horse sickness virus and Yunnan orbivirus, isolated from vertebrates and mosquitoes in Peru and Australia.
During 1997, two new viruses were isolated from outbreaks of disease that occurred in horses, donkeys, cattle and sheep in Peru. Genome characterization showed that the virus isolated from horses (with neurological disorders, 78% fatality) belongs to a new species the Peruvian horse sickness virus (PHSV), within the genus Orbivirus, family Reoviridae. This represents the first isolation of PHSV, which was subsequently also isolated during 1999, from diseased horses in the Northern Territory of Australia (Elsey virus, ELSV). Serological and molecular studies showed that PHSV and ELSV are very similar in the serotype-determining protein (99%, same serotype). The second virus (Rioja virus, RIOV) was associated with neurological signs in donkeys, cattle, sheep and dogs and was shown to be a member of the species Yunnan orbivirus (YUOV). RIOV and YUOV are also almost identical (97% amino acid identity) in the serotype-determining protein. YUOV was originally isolated from mosquitoes in China.
Attoui
Houssam
H
Department of Vector Borne Diseases, Institute for Animal Health, Pirbright, Woking, Surrey, GU24 0NF, UK. houssam.attoui@bbsrc.ac.uk
Mendez-Lopez
Maria Rosario
MR
Rao
Shujing
S
Hurtado-Alendes
Ana
A
Lizaraso-Caparo
Frank
F
Mohd Jaafar
Fauziah
F
Samuel
Alan R
AR
Belhouchet
Mourad
M
Pritchard
Lindsay I
LI
Melville
Lorna
L
Weir
Richard P
RP
Hyatt
Alex D
AD
Davis
Steven S
SS
Lunt
Ross
R
Calisher
Charles H
CH
Tesh
Robert B
RB
Fujita
Ricardo
R
Mertens
Peter P C
PP
D000818:Animals; D001483:Base Sequence; D002417:Cattle; D009033:Culicidae / Q000821:virology; D004196:Disease Outbreaks / Q000662:veterinary; D004285:Dogs; D018397:Equidae / Q000821:virology; D006734:Horse Diseases / Q000453:epidemiology / Q000821:virology*; D006736:Horses / Q000821:virology; D046529:Microscopy, Electron, Transmission; D017720:Molecular Epidemiology; D015876:Northern Territory; D018163:Orbivirus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification* / Q000472:pathogenicity; D010568:Peru; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics; D012088:Reoviridae Infections / Q000453:epidemiology / Q000662:veterinary* / Q000821:virology; D012703:Serotyping; D014764:Viral Proteins / Q000235:genetics
D012367:RNA, Viral; D014764:Viral Proteins