title: Species distribution and in vitro susceptibility of Candida bloodstream isolates to six new and current antifungal agents in a Turkish tertiary care military hospital, recovered through 2001 and 2006.
abstract: OBJECTIVE
  Species distribution and antifungal susceptibility of Candida bloodstream isolates.
  
  
  METHODS
  173 Candida species recovered from fungemic patients admitted to the largest tertiary-care military hospital between 2001 and 2006 in Ankara, Turkey evaluated retrospectively. Antifungal susceptibility of 95 isolates (45 Candida parapsilosis, 35 C. albicans, 7 C. tropicalis, 4 C. krusei, 3 C. glabrata, and 1 C. kefyr) was determined against fluconazole, itraconazole, voriconazole, posaconazole, caspofungin, and amphotericin B.
  
  
  RESULTS
  C. albicans was the most common yeast (48.0%), followed by C. parapsilosis. Almost all strains showed low minimal inhibitory concentration (MIC) values to all six antifungals tested. Only 2 of 45 C. parapsilosis isolates were resistant to fluconazole, one was susceptible in a dose-dependent manner (SDD) to itraconazole, and 14 were nonsusceptible to caspofungin.
  
  
  CONCLUSIONS
  Increasing prevalence of C. parapsilosis emphasizes a need for better catheter care and continuous surveillance programs.
authors.affiliation: Department of Medical Microbiology, Gulhane Military Medical Academy and School of Medicine, 06018 Etlik, Ankara, Turkey.
authors.forename: Mehmet A
authors.initials: MA
authors.lastname: Saracli
authors.forename: Ramazan
authors.initials: R
authors.lastname: Gumral
authors.forename: Hanefi C
authors.initials: HC
authors.lastname: Gul
authors.forename: Ahmet
authors.initials: A
authors.lastname: Gonlum
authors.forename: Sinasi T
authors.initials: ST
authors.lastname: Yildiran
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use*; D002175:Candida / Q000187:drug effects* / Q000302:isolation & purification; D002177:Candidiasis / Q000097:blood / Q000188:drug therapy*; D005260:Female; D006772:Hospitals, Military / Q000706:statistics & numerical data*; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008826:Microbial Sensitivity Tests; D014421:Turkey
chemical_list: D000935:Antifungal Agents