title: Gigantomastia and autoimmunity: a case report.
abstract: Gigantomastia is a rare breast condition characterised by diffuse, rapid, and excessive breast hypertrophy that can result in symptoms ranging from pain to necrosis and sepsis. It typically occurs in the setting of marked hormonal changes such as puberty and pregnancy. Rarely, gigantomastia has been reported to develop in the setting of an autoimmune illness. We present a case of gigantomastia developing in a patient with systemic lupus erythematosus, who was treated with methotrexate and bilateral mammoplasty.
authors.affiliation: Department of Dermatology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA.
authors.forename: E N
authors.initials: EN
authors.lastname: Le
authors.forename: L Y
authors.initials: LY
authors.lastname: McGirt
authors.forename: R
authors.initials: R
authors.lastname: Abuav
mesh_terms: D000328:Adult; D018501:Antirheumatic Agents / Q000627:therapeutic use; D015551:Autoimmunity / Q000276:immunology*; D001940:Breast / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D006984:Hypertrophy / Q000209:etiology / Q000473:pathology / Q000628:therapy; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000473:pathology; D016462:Mammaplasty; D008727:Methotrexate / Q000627:therapeutic use; D011247:Pregnancy
chemical_list: D018501:Antirheumatic Agents; D008727:Methotrexate