title: A new cytotoxic iridoid from Callicarpa nudiflora.
abstract: A new iridoid, named nudifloside (1), together with three known compounds, was isolated from the EtOH extract of the aerial parts of Callicarpa nudiflora Hook. The structures were elucidated by a study of their physical and spectral data. Nudifloside (1) and the isolated known compound linearoside (2) displayed inhibitory effects towards chronic myelogenous leukaemia K562 cell line, with IC(50) values of 20.7 and 36.0 microg mL(-1), respectively.
authors.affiliation: Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, 571101, Hainan, PR China.
authors.forename: Wen-Li
authors.initials: WL
authors.lastname: Mei
authors.forename: Zhuang
authors.initials: Z
authors.lastname: Han
authors.forename: Hai-Bin
authors.initials: HB
authors.lastname: Cui
authors.forename: You-Xing
authors.initials: YX
authors.lastname: Zhao
authors.forename: Yuan-Yuan
authors.initials: YY
authors.lastname: Deng
authors.forename: Hao-Fu
authors.initials: HF
authors.lastname: Dai
mesh_terms: D032408:Callicarpa / Q000737:chemistry*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D039823:Iridoids / Q000737:chemistry* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D035261:Plant Components, Aerial / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D039823:Iridoids; D010936:Plant Extracts