title: Complications of Evans' syndrome in an infant with hereditary spherocytosis: a case report.
abstract: Hereditary spherocytosis (HS) is a genetic disorder of the red blood cell membrane clinically characterized by anemia, jaundice and splenomegaly. Evans' syndrome is a clinical syndrome characterized by autoimmune hemolytic anemia (AIHA) accompanied by immune thrombocytopenic purpura (ITP). It results from a malfunction of the immune system that produces multiple autoantibodies targeting at least red blood cells and platelets. HS and Evans' syndrome have different mechanisms of pathophysiology one another. We reported the quite rare case of an infant who had these diseases concurrently. Possible explanations of the unexpected complication are discussed.
authors.affiliation: Department of Pediatrics, Matsushita Memorial Hospital, Moriguchi, Japan. hide0519@koto.kpu-m.ac.jp
authors.forename: Hideki
authors.initials: H
authors.lastname: Yoshida
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Ishida
authors.forename: Takao
authors.initials: T
authors.lastname: Yoshihara
authors.forename: Takashi
authors.initials: T
authors.lastname: Oyamada
authors.forename: Masataka
authors.initials: M
authors.lastname: Kuwana
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Imamura
authors.forename: Akira
authors.initials: A
authors.lastname: Morimoto
mesh_terms: D000744:Anemia, Hemolytic, Autoimmune / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D007223:Infant; D008297:Male; D010976:Platelet Count; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D013103:Spherocytosis, Hereditary / Q000097:blood / Q000150:complications* / Q000175:diagnosis*; D013577:Syndrome