Oral contraceptives and family history of breast cancer.
BACKGROUND
Questions remain regarding whether oral contraceptive (OC) use among women with a family history of breast cancer increases disease risk.


METHODS
We conducted a systematic review by searching MEDLINE and CENTRAL databases for evidence (in all languages) published in peer-reviewed journals from 1966 to July 2008 that provided estimates of breast cancer risk according to family history. Twelve articles were identified and the quality of each study was assessed using the United States Preventive Services Task Force grading system.


RESULTS
Results from 10 studies and one pooled analysis of 54 studies suggest that the use of OCs does not significantly modify the risk of breast cancer among women with a familial history of breast cancer; however, evidence from four studies shows that some women may be at a greater risk, particularly women who took OCs prior to 1975.


CONCLUSIONS
Current evidence shows that women with a family history of breast cancer do not increase their disease risk by using OCs.
Gaffield
Mary E
ME
Department of Reproductive Health and Research, World Health Organization, 1211 Geneva 27, Switzerland. gaffieldm@who.int
Culwell
Kelly R
KR
Ravi
Anita
A
D001943:Breast Neoplasms / Q000235:genetics*; D003276:Contraceptives, Oral / Q000627:therapeutic use*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D012306:Risk; D012307:Risk Factors
D003276:Contraceptives, Oral