title: Role of fine needle aspiration cytology in the diagnosis and management of Warthin's tumour of the salivary glands.
abstract: OBJECTIVE
  Local excision surgical procedures and non-surgical conservative management are considered alternatives to superficial parotidectomy in the treatment and management of Warthin's tumour (WT). Such therapeutic alternatives demand accurate diagnosis. In order to determine whether fine needle aspiration cytology (FNAC) is capable of rendering such a minimally invasive diagnosis, we evaluated its accuracy and diagnostic parameters in a large series of histologically proven cases of WT.
  
  
  METHODS
  A cytohistological study of 116 salivary tumours from 110 patients (four WT were bilateral) with a histological or cytological diagnosis of WT.
  
  
  RESULTS
  Histology confirmed the cytological diagnosis in 103 of 114 tumours (90.4%). Two tumours were incorrectly diagnosed on cytology as WT. In 11 cases of WT there was an erroneous or non-representative cytological diagnosis. The sensitivity was 90.4%, and positive predictive value 98.1%. Regarding malignancy, there were three misdiagnoses. One tumour diagnosed as WT was a low-grade mucoepidermoid carcinoma. Two cases considered 'suspicious of squamous cell carcinoma' corresponded to WT. After review, 81.3% of the cases of WT were considered typical and 18.7% non-typical; all misdiagnoses were in the latter group. Cytological difficulties could be divided into three areas: (i) absence of one or more diagnostic components; (ii) 'squamoid' pattern; and (iii) mucinous metaplasia. Degenerated oncocytes were present in 65% of cases.
  
  
  CONCLUSIONS
  FNAC offers the possibility of a reliable diagnosis of WT. Pathologists must pay attention to the squamous appearance of degenerated oncocytes. Cytology, when coupled with clinical and image findings, may permit conservative tumour management.
authors.affiliation: Department of Pathology, University Hospital La Paz, Madrid, Spain.
authors.forename: J M
authors.initials: JM
authors.lastname: Viguer
authors.forename: B
authors.initials: B
authors.lastname: Vicandi
authors.forename: J A
authors.initials: JA
authors.lastname: Jiménez-Heffernan
authors.forename: P
authors.initials: P
authors.lastname: López-Ferrer
authors.forename: P
authors.initials: P
authors.lastname: González-Peramato
authors.forename: C
authors.initials: C
authors.lastname: Castillo
mesh_terms: D000235:Adenolymphoma / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044963:Biopsy, Fine-Needle; D002294:Carcinoma, Squamous Cell / Q000473:pathology; D005188:False Negative Reactions; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012468:Salivary Gland Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy*; D012469:Salivary Glands / Q000473:pathology*