Post-transplant increased levels of serum sCD30 is a marker for prediction of kidney allograft loss in a 5-year prospective study.
BACKGROUND
Levels of sCD30 represent a biomarker for early outcome in kidney transplantation. The purpose of this study was to determine the role of sCD30 levels for prediction of graft loss in the late post-transplant period.


METHODS
Sera were collected immediately pre-transplant and yearly thereafter for up to 5-year post-transplant in 37 primary renal transplant recipients. Levels of serum sCD30 were tested using a fluorescent microsphere assay.


RESULTS
Levels of sCD30 significantly decreased after transplantation and remained normal in 34 patients without graft loss up to 5-year post-transplant. Elevated levels of serum sCD30 preceded the increase of serum creatinine in patients with subsequent graft loss.


CONCLUSIONS
Elevated levels of serum sCD30 post-transplant might be a marker for predicting subsequent graft loss in the post-transplant period.
Delgado
Julio C
JC
Department of Pathology, ARUP Institute for Clinical & Experimental Pathology, University of Utah, Salt Lake City, UT 84108, United States. julio.delgado@path.utah.edu
Pavlov
Igor Y
IY
Shihab
Fuad S
FS
D000328:Adult; D015415:Biomarkers / Q000097:blood; D001769:Blood / Q000187:drug effects; D003404:Creatinine / Q000097:blood; D005260:Female; D006084:Graft Rejection / Q000097:blood*; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology; D017730:Ki-1 Antigen / Q000097:blood*; D016030:Kidney Transplantation / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D015166:Monitoring, Immunologic; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic; D014184:Transplantation, Homologous
D015415:Biomarkers; D007166:Immunosuppressive Agents; D017730:Ki-1 Antigen; D003404:Creatinine