title: Hyperprolactinaemia with amisulpride.
abstract: Amisulpride, a substituted benzamide derivative, is a second-generation antipsychotic that preferentially binds to D2/D3 receptors in limbic rather than striatal structures. High dosage preferentially antagonizes postsynaptic receptors, resulting in reduced dopamine transmission; and low dosage blocks presynaptic receptors, resulting in enhanced transmission. Hyperprolactinaemia may occur in patients receiving amisulpride at low dose of 50 mg/day and results in galactorrhoea, amenorrhea and sexual dysfunction. The symptom ameliorates on withdrawing the drug, switching to non-prolactin-elevating drugs, and timely management with dopamine agonist.
authors.affiliation: Department of Psychiatry, GMC and Rajindra Hospital, Patiala, India.
authors.forename: Rajnish
authors.initials: R
authors.lastname: Raj
authors.forename: Balwant Singh
authors.initials: BS
authors.lastname: Sidhu