title: Infections may have a protective role in the etiopathogenesis of celiac disease.
abstract: Infectious agents have been implicated in the pathogenesis of many autoimmune diseases via various pathogenic mechanisms, such as molecular mimicry, resulting in modulation of the host's immune tolerance. In the following article we examine the association between serological evidence of past infection with Toxoplasma gondii, rubella virus, cytomegalovirus, Treponema pallidum, and Epstein-Barr virus, and the co-existence of celiac disease. Our results imply that certain infections may generate an immunological environment that disfavors future appearance of certain autoimmune conditions such as celiac disease.
authors.affiliation: Department of Medicine D, Meir Medical Center, Kfar-Saba, Israel.
authors.forename: Leeor
authors.initials: L
authors.lastname: Plot
authors.forename: Howard
authors.initials: H
authors.lastname: Amital
authors.forename: Ori
authors.initials: O
authors.lastname: Barzilai
authors.forename: Maya
authors.initials: M
authors.lastname: Ram
authors.forename: Nicola
authors.initials: N
authors.lastname: Bizzaro
authors.forename: Bizzaro
authors.initials: B
authors.lastname: Nicola
authors.forename: Yehuda
authors.initials: Y
authors.lastname: Shoenfeld
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D000913:Antibodies, Protozoan / Q000097:blood; D000914:Antibodies, Viral / Q000097:blood; D002446:Celiac Disease / Q000097:blood / Q000209:etiology / Q000276:immunology*; D003587:Cytomegalovirus / Q000276:immunology; D004854:Herpesvirus 4, Human / Q000276:immunology; D006801:Humans; D007118:Immunoassay / Q000379:methods; D012412:Rubella virus / Q000276:immunology; D013587:Syphilis / Q000150:complications / Q000276:immunology; D014122:Toxoplasma / Q000276:immunology; D014123:Toxoplasmosis / Q000150:complications / Q000276:immunology*; D014210:Treponema pallidum / Q000276:immunology; D014777:Virus Diseases / Q000150:complications / Q000276:immunology*
chemical_list: D000907:Antibodies, Bacterial; D000913:Antibodies, Protozoan; D000914:Antibodies, Viral