title: Two novel ternary albendazole-cyclodextrin-polymer systems: dissolution, bioavailability and efficacy against Taenia crassiceps cysts.
abstract: The effect of two water-soluble polymers: pectin and polyvinylpyrrolidone in combination with beta-cyclodextrin, on the dissolution, bioavailability and cysticidal efficacy of albendazole was evaluated using a commercial suspension as reference product. The dissolution of the albendazole-beta-cyclodextrin-pectin formulation was slow and incomplete (44.7%). No statistical differences in C(max) and AUC were found between this formulation and the reference. Also its cysticidal efficacy (33%) was similar to the reference (38%). The albendazole-beta-cyclodextrin-polyvinylpyrrolidone formulation exhibited the highest dissolution rate (78.5%) and its bioavailability was also significantly increased (2.3-fold). In addition, the cysticidal activity of this formulation (83%) was greater than a commercial suspension. Our results suggest that the ternary system of albendazole-beta-cyclodextrin-polyvinylpyrrolidone could be a potential alternative for the treatment of systemic helmintic diseases and it is worth to continue its preclinical evaluation.
authors.affiliation: Laboratorio de Neuropsicofarmacología, Instituto Nacional de Neurología y Neurocirugía. México DF, 14269, Mexico. ingpalomares@yahoo.com.mx
authors.forename: Francisca
authors.initials: F
authors.lastname: Palomares-Alonso
authors.forename: Cesar Rivas
authors.initials: CR
authors.lastname: González
authors.forename: Ma Josefa
authors.initials: MJ
authors.lastname: Bernad-Bernad
authors.forename: María Dolores Castillo
authors.initials: MD
authors.lastname: Montiel
authors.forename: Guadalupe Palencia
authors.initials: GP
authors.lastname: Hernández
authors.forename: Iliana
authors.initials: I
authors.lastname: González-Hernández
authors.forename: Nelly
authors.initials: N
authors.lastname: Castro-Torres
authors.forename: Enrique Pinzón
authors.initials: EP
authors.lastname: Estrada
authors.forename: Helgi
authors.initials: H
authors.lastname: Jung-Cook
mesh_terms: D015766:Albendazole / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology*; D000818:Animals; D000923:Anticestodal Agents / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010368:Pectins / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013621:Taenia / Q000187:drug effects*; D047392:beta-Cyclodextrins / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology*
chemical_list: D000923:Anticestodal Agents; D047392:beta-Cyclodextrins; D010368:Pectins; D015766:Albendazole; C031215:betadex