Development of herpes simplex virus stomatitis during receipt of cidofovir therapy.
We report 3 children who, after undergoing hematopoietic stem cell transplant, developed herpes simplex virus (HSV) stomatitis while receiving weekly cidofovir as preemptive treatment for cytomegalovirus infection. All patients responded well to treatment with either acyclovir or ganciclovir. Despite the in vitro susceptibility of HSV to cidofovir, once-weekly treatment with this agent may not be adequate prophylaxis in pediatric patients.
Dvorak
Christopher C
CC
Division of Pediatric Blood and Marrow Transplant, University of California, San Francisco, California 94143-1278, USA. dvorakc@peds.ucsf.edu
Cowan
Morton J
MJ
Horn
Biljana
B
Weintrub
Peggy S
PS
D000212:Acyclovir / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use*; D018890:Chemoprevention / Q000379:methods*; D002648:Child; D002675:Child, Preschool; D000077404:Cidofovir; D003586:Cytomegalovirus Infections / Q000517:prevention & control; D003596:Cytosine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D015774:Ganciclovir / Q000627:therapeutic use; D006801:Humans; D008297:Male; D063065:Organophosphonates / Q000627:therapeutic use*; D018139:Simplexvirus / Q000302:isolation & purification*; D033581:Stem Cell Transplantation; D013280:Stomatitis / Q000188:drug therapy / Q000821:virology*; D016896:Treatment Outcome
D000998:Antiviral Agents; D063065:Organophosphonates; D003596:Cytosine; D000077404:Cidofovir; D015774:Ganciclovir; D000212:Acyclovir