Zeta-crystallin: a tale of two cells.
Szutkowska et al. demonstrate that zeta-crystallin plays an essential role in the stabilization of the Na(+)/K(+)/2Cl(-) cotransporter mRNA in the medullary thick ascending limb. However, differential effects of experiments using small interfering RNA to knock down zeta-crystallin in proximal tubule and thick ascending limb cells suggest that additional proteins must contribute to the rapid turnover and selective stabilization of the various mRNAs during metabolic acidosis.
Curthoys
Norman P
NP
Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, Colorado 80523-1870, USA. Norman.Curthoys@Colostate.edu
D000138:Acidosis / Q000235:genetics*; D000818:Animals; D006801:Humans; D007679:Kidney Medulla; D007687:Kidney Tubules, Proximal; D020871:RNA Stability; D034741:RNA, Small Interfering; D028021:Sodium-Potassium-Chloride Symporters / Q000235:genetics; D038226:zeta-Crystallins / Q000502:physiology*
D034741:RNA, Small Interfering; D028021:Sodium-Potassium-Chloride Symporters; D038226:zeta-Crystallins