Genetic diversity of HIV type 1 along the coastal strip of Kenya.
A study on the genetic diversity of HIV-1 subtypes present along the coastal strip of Kenya, i.e., Kilifi, Mombasa, Msambweni, and Malindi districts, was carried out. DNA sequences for regions encoding a portion of the env-gp41 region of the virus were generated by PCR and sequenced directly. Eighty six samples that were successfully sequenced were analyzed. From the analysis, 86% (74) were subtype A1, 5% (4) were subtype C, 8% (7) were subtype D, and 1% (1) was subtype G. This study shows that HIV-1 subtype A1 is the most dominant subtype in circulation in this region.
Khamadi
Samoel A
SA
Kenya Medical Research Institute, Nairobi, Kenya. skhamadi@kemri.org
Lihana
Raphael W
RW
Osman
Saida
S
Mwangi
Joseph
J
Muriuki
Joseph
J
Lagat
Nancy
N
Kinyua
Joyceline
J
Mwau
Matilu
M
Kageha
Sheila
S
Okoth
Vincent
V
Ochieng
Washington
W
Okoth
Fredrick A
FA
D016000:Cluster Analysis; D014644:Genetic Variation; D005838:Genotype; D015700:HIV Envelope Protein gp41 / Q000235:genetics; D015658:HIV Infections / Q000821:virology*; D015497:HIV-1 / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D007630:Kenya; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D017422:Sequence Analysis, DNA; D017385:Sequence Homology
D015700:HIV Envelope Protein gp41