Levels of neuregulin 1 and 3 proteins in Brodmann's area 46 from subjects with schizophrenia and bipolar disorder.
Neuregulin (NRG) 1Ialpha and NRG3 proteins levels were measured in Brodmann's area 46 from 20 subjects with schizophrenia, 8 subjects with bipolar 1 disorder and 20 age-sex matched control subjects. Protein levels of both NRG1Ialpha and NRG3 were unchanged in both psychiatric illnesses. These data suggest any change in NRG1Ialpha and NRG3 expression in schizophrenia or bipolar 1 disorder do not result in changes levels in levels of those proteins Brodmann's area 46.
Boer
Simone
S
The Rebecca L. Cooper Research Laboratories, The Mental Health Research Institute, Victoria 3052, Australia. anddali@unimelb.edu.au
Berk
Michael
M
Dean
Brian
B
D001714:Bipolar Disorder / Q000378:metabolism*; D006801:Humans; D020890:Neuregulin-1 / Q000235:genetics / Q000378:metabolism*; D020880:Neuregulins / Q000235:genetics / Q000378:metabolism*; D017397:Prefrontal Cortex / Q000378:metabolism*; D020033:Protein Isoforms; D012559:Schizophrenia / Q000378:metabolism*
C094131:NRG1 protein, human; C486357:NRG3 protein, human; D020890:Neuregulin-1; D020880:Neuregulins; D020033:Protein Isoforms