Prothrombin complex concentrate (Beriplex P/N).
Beriplex P/N, a prothrombin complex concentrate derived from pooled human plasma, contains the vitamin K-dependent coagulation factors II, VII, IX and X, and the vitamin K-dependent coagulation inhibition proteins C and S. Intravenous Beriplex P/N provided rapid and sustained normalization of elevated international normalized ratios and controlled bleeding in adult patients participating in several prospective, noncomparative clinical studies (n = 8-43), with these data supported by clinical experience during its use over more than a decade. Based on extensive clinical experience, Beriplex P/N is also effective in the treatment of congenital deficiency of any of the vitamin K-dependent coagulation factors when purified specific coagulation factor products are not available. Over a decade of clinical experience and more limited data from clinical studies have shown that intravenous infusions of Beriplex P/N were generally well tolerated in adult patients with acquired or congenital deficiencies of the vitamin K-dependent coagulation factors. To date, there have been no proven cases of viral transmission reported in any published studies.
Scott
Lesley J
LJ
Adis, a Wolters Kluwer Business, Auckland, New Zealand. demail@adis.co.nz
D000925:Anticoagulants / Q000627:therapeutic use; D004338:Drug Combinations; D005164:Factor IX / Q000627:therapeutic use*; D005167:Factor VII / Q000627:therapeutic use*; D005170:Factor X / Q000627:therapeutic use*; D006470:Hemorrhage / Q000188:drug therapy*; D006801:Humans; D007020:Hypoprothrombinemias / Q000188:drug therapy*; D011516:Prothrombin / Q000627:therapeutic use*; D014813:Vitamin K Deficiency / Q000188:drug therapy*
D000925:Anticoagulants; D004338:Drug Combinations; C525441:factor IX, factor VII, factor X, prothrombin drug combination; D005167:Factor VII; D011516:Prothrombin; D005164:Factor IX; D005170:Factor X