Ischemia-modified albumin in the diagnosis of pulmonary embolism: an experimental study.
OBJECTIVE
We designed this experimental study to determine the value of ischemia-modified albumin in the diagnosis of pulmonary embolism.


METHODS
Twenty-four mature female New Zealand rabbits were divided into 4 groups, each consisting of 6 animals. These were classified into group 1 ,the control group; group 2, the deep venous thrombosis group; group 3, the deep venous thrombosis with pulmonary embolism group; and group 4, the pulmonary embolism-alone group. Deep venous thrombosis was produced by ligation of the iliac vein. To establish pulmonary embolism, 2 clots were administered from the iliac vein. Blood samples were taken from all the groups at hours 0, 1, 3, and 6 for ischemia-modified albumin measurement.


RESULTS
Pulmonary embolism was established in all the rabbits in groups 3 and 4, and this was confirmed by tomographic and histologic findings. Measurement of mean ischemia-modified albumin levels for all rabbits at hours 0, 1, 3, and 6 revealed that mean ischemia-modified albumin levels in groups 3 and 4 were statistically significantly higher than those in groups 1 and 2. There was no difference between the mean ischemia-modified albumin levels in groups 1 and 2 nor between groups 3 and 4. The alteration in ischemia-modified albumin levels over time was statistically significant.


CONCLUSIONS
The results of our experimental study demonstrate that ischemia-modified albumin levels may be useful in the diagnosis of pulmonary embolism.
Turedi
Suleyman
S
Department of Emergency Medicine, Karadeniz Technical University Faculty of Medicine, Trabzon, Turkey. suleymanturedi@hotmail.com
Patan
Tevfik
T
Gunduz
Abdulkadir
A
Mentese
Ahmet
A
Tekinbas
Celal
C
Topbas
Murat
M
Karahan
Suleyman Caner
SC
Yulug
Esin
E
Turkmen
Suha
S
Ucar
Utku
U
D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D004195:Disease Models, Animal; D005260:Female; D007511:Ischemia / Q000378:metabolism*; D011237:Predictive Value of Tests; D011655:Pulmonary Embolism / Q000175:diagnosis*; D011817:Rabbits; D012709:Serum Albumin / Q000378:metabolism*
D015415:Biomarkers; D012709:Serum Albumin