title: Pegfilgrastim primary prophylaxis vs. current practice neutropenia management in elderly breast cancer patients receiving chemotherapy.
abstract: We investigated the incidences of febrile neutropenia (FN) and related complications in elderly (> or =65 years) breast cancer patients receiving chemotherapy supported by pegfilgrastim primary prophylaxis (PP; n=150) or current practice (CP) neutropenia management (n=104) in a subanalysis of NeuCuP (Neulasta) vs. current practice neutropenia management). Studies involving regimens with moderately high to high (> or =15%) FN risk were identified by literature review, and individual patient data were integrated for analysis. FN incidence was 6% (95% CI: 2, 10%) in the PP group and 24% (95% CI: 16, 32%) in the CP group. In cycle 1, incidences were 3 and 15%, respectively. FN-related hospitalisation incidence was 5% (PP group) and 15% (CP group), while dose reductions (>/=15%) occurred in 15 and 29% of patients. Pegfilgrastim provided effective PP in elderly patients, a population who may be vulnerable to chemotherapy-related FN and for whom current practice may not provide adequate protection.
authors.affiliation: Institut Multidisciplinaire d'Oncologie (IMO), Clinique de Genolier, 1 Route du Muids, 1272 Genolier, Switzerland. maapro@genolier.net
authors.forename: Matti
authors.initials: M
authors.lastname: Aapro
authors.forename: Matthias
authors.initials: M
authors.lastname: Schwenkglenks
authors.forename: Gary H
authors.initials: GH
authors.lastname: Lyman
authors.forename: Antonio
authors.initials: A
authors.lastname: Lopez Pousa
authors.forename: Susan
authors.initials: S
authors.lastname: Lawrinson
authors.forename: Tomas
authors.initials: T
authors.lastname: Skacel
authors.forename: Pamela
authors.initials: P
authors.lastname: Bacon
authors.forename: Gunter
authors.initials: G
authors.lastname: von Minckwitz
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects; D001943:Breast Neoplasms / Q000150:complications / Q000188:drug therapy*; D005260:Female; D000069585:Filgrastim; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D009503:Neutropenia / Q000150:complications / Q000188:drug therapy*; D011092:Polyethylene Glycols; D011994:Recombinant Proteins
chemical_list: D000970:Antineoplastic Agents; D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; C455861:pegfilgrastim; D011092:Polyethylene Glycols; D000069585:Filgrastim