title: Multiple loci on 8q24 associated with prostate cancer susceptibility.
abstract: Previous studies have identified multiple loci on 8q24 associated with prostate cancer risk. We performed a comprehensive analysis of SNP associations across 8q24 by genotyping tag SNPs in 5,504 prostate cancer cases and 5,834 controls. We confirmed associations at three previously reported loci and identified additional loci in two other linkage disequilibrium blocks (rs1006908: per-allele OR = 0.87, P = 7.9 x 10(-8); rs620861: OR = 0.90, P = 4.8 x 10(-8)). Eight SNPs in five linkage disequilibrium blocks were independently associated with prostate cancer susceptibility.
authors.affiliation: Cancer Research UK Genetic Epidemiology Unit, University of Cambridge, Cambridge, UK.
authors.forename: Ali Amin
authors.initials: AA
authors.lastname: Al Olama
authors.forename: Zsofia
authors.initials: Z
authors.lastname: Kote-Jarai
authors.forename: Graham G
authors.initials: GG
authors.lastname: Giles
authors.forename: Michelle
authors.initials: M
authors.lastname: Guy
authors.forename: Jonathan
authors.initials: J
authors.lastname: Morrison
authors.forename: Gianluca
authors.initials: G
authors.lastname: Severi
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Leongamornlert
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Tymrakiewicz
authors.forename: Sameer
authors.initials: S
authors.lastname: Jhavar
authors.forename: Ed
authors.initials: E
authors.lastname: Saunders
authors.forename: John L
authors.initials: JL
authors.lastname: Hopper
authors.forename: Melissa C
authors.initials: MC
authors.lastname: Southey
authors.forename: Kenneth R
authors.initials: KR
authors.lastname: Muir
authors.forename: Dallas R
authors.initials: DR
authors.lastname: English
authors.forename: David P
authors.initials: DP
authors.lastname: Dearnaley
authors.forename: Audrey T
authors.initials: AT
authors.lastname: Ardern-Jones
authors.forename: Amanda L
authors.initials: AL
authors.lastname: Hall
authors.forename: Lynne T
authors.initials: LT
authors.lastname: O'Brien
authors.forename: Rosemary A
authors.initials: RA
authors.lastname: Wilkinson
authors.forename: Emma
authors.initials: E
authors.lastname: Sawyer
authors.forename: Artitaya
authors.initials: A
authors.lastname: Lophatananon
authors.forename: Alan
authors.initials: A
authors.lastname: Horwich
authors.forename: Robert A
authors.initials: RA
authors.lastname: Huddart
authors.forename: Vincent S
authors.initials: VS
authors.lastname: Khoo
authors.forename: Christopher C
authors.initials: CC
authors.lastname: Parker
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Woodhouse
authors.forename: Alan
authors.initials: A
authors.lastname: Thompson
authors.forename: Tim
authors.initials: T
authors.lastname: Christmas
authors.forename: Chris
authors.initials: C
authors.lastname: Ogden
authors.forename: Colin
authors.initials: C
authors.lastname: Cooper
authors.forename: Jenny L
authors.initials: JL
authors.lastname: Donovan
authors.forename: Freddie C
authors.initials: FC
authors.lastname: Hamdy
authors.forename: David E
authors.initials: DE
authors.lastname: Neal
authors.forename: Rosalind A
authors.initials: RA
authors.lastname: Eeles
authors.forename: Douglas F
authors.initials: DF
authors.lastname: Easton
mesh_terms: D002898:Chromosomes, Human, Pair 8; D004198:Disease Susceptibility; D015894:Genome, Human; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms / Q000235:genetics*; D012307:Risk Factors