title: Studies on anti-inflammatory, antipyretic and analgesic properties of Caesalpinia bonducella F. seed oil in experimental animal models.
abstract: Caesalpinia bonducella FLEMING (Caesalpiniaceae) plant is well known for its medicinal and therapeutic values in Indian Ayurveda. However, to be clinically useful, more scientific data are needed. Therefore, in the present study, we investigated the effects of C. bonducella seed oil on acute and chronic inflammation. To assess the anti-inflammatory, antipyretic and analgesic activities, varied concentrations of the seed oil of C. bonducella (100, 200 and 400mg/kg orally) were tested in carrageenan-induced rat paw oedema, brewer's yeast-induced pyrexia, acetic acid-induced writhing and hot plate reaction time in experimental rats. The paw volumes, pyrexia and writhes in experimental rats were reduced significantly (p<0.05) as compared to that of control, and hot plate test showed significant licking effect in rats. These results clearly indicate that the oil of C. bonducella seeds could be a potential source for using as anti-inflammatory, antipyretic and analgesic agent.
authors.affiliation: Faculty of Life Sciences, Department of Botany, Dr HS Gour University, Sagar 470003, Madhya Pradesh, India. s.microb@yahoo.com
authors.forename: Shruti
authors.initials: S
authors.lastname: Shukla
authors.forename: Archana
authors.initials: A
authors.lastname: Mehta
authors.forename: Pradeep
authors.initials: P
authors.lastname: Mehta
authors.forename: Suresh Prasad
authors.initials: SP
authors.lastname: Vyas
authors.forename: Savita
authors.initials: S
authors.lastname: Shukla
authors.forename: Vivek K
authors.initials: VK
authors.lastname: Bajpai
mesh_terms: D019342:Acetic Acid; D018712:Analgesics, Non-Narcotic; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001522:Behavior, Animal / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D029911:Caesalpinia / Q000737:chemistry*; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D005260:Female; D005528:Foot / Q000473:pathology; D006614:Hindlimb / Q000473:pathology; D008297:Male; D010147:Pain Measurement / Q000187:drug effects; D010938:Plant Oils / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D011930:Reaction Time / Q000187:drug effects; D012441:Saccharomyces cerevisiae; D012639:Seeds / Q000737:chemistry
chemical_list: D018712:Analgesics, Non-Narcotic; D000894:Anti-Inflammatory Agents, Non-Steroidal; D010938:Plant Oils; D002351:Carrageenan; D019342:Acetic Acid