title: Dual infection with dengue virus 3 and human immunodeficiency virus 1 in Havana, Cuba.
abstract: Although dengue virus (DEN) endemic regions overlap with human immunodeficiency virus 1 (HIV) high incidence areas, little has been documented on HIV and DEN mixed infection. Here we report DEN/HIV concurrent infections recorded during the DEN-3 epidemic in 2001-2002 in Havana. Serologic-confirmed DEN is described in two HIV-infected subjects with dengue fever symptoms. Although patients had dengue disease, the CD4+ cells remained within normal levels and no accelerated progression of HIV disease was observed. To our knowledge, DEN cases caused by DEN-3 in HIV-infected individuals have not been reported previously. Further research is needed to diagnose this likely underreported mixed viral infection in DEN endemic areas.
authors.affiliation: Department of Medicine, Pedro Kouri Tropical Medicine Institute, Havana, Cuba.
authors.forename: Daniel
authors.initials: D
authors.lastname: Gonzalez
authors.forename: Daniel
authors.initials: D
authors.lastname: Limonta
authors.forename: Juan Francisco
authors.initials: JF
authors.lastname: Bandera
authors.forename: Jorge
authors.initials: J
authors.lastname: Perez
authors.forename: Gustavo
authors.initials: G
authors.lastname: Kouri
authors.forename: Maria G
authors.initials: MG
authors.lastname: Guzman
mesh_terms: D000328:Adult; D018791:CD4 Lymphocyte Count; D003462:Cuba; D003715:Dengue / Q000150:complications* / Q000175:diagnosis* / Q000453:epidemiology; D003716:Dengue Virus / Q000302:isolation & purification; D015658:HIV Infections / Q000150:complications* / Q000175:diagnosis*; D015497:HIV-1 / Q000302:isolation & purification; D006801:Humans; D008297:Male; D055815:Young Adult