title: Histological evaluation of alveolar ridge augmentation using injectable calcium phosphate bone cement in dogs.
abstract: Alveolar ridge augmentation is an important procedure to restore tooth loss. Several types of graft materials have been used for augmenting the alveolar ridge. An injectable calcium phosphate cement (CPC) has been applied to periodontal bone defects and has shown favourable results. Thus, this CPC may work as an effective graft material for alveolar ridge augmentation. The aim of this study was to evaluate the effectiveness of the CPC for large-scaled (about 7 x 8 x 6 mm) ridge augmentation in dogs. Alveolar ridge defects were created bilaterally in the maxilla of six beagle dogs. The CPC was applied to one of the bilateral maxillary defects. The untreated defect on the contralateral side served as control. The animals were sacrificed at 6 months after surgery and decalcified histological specimens of the alveolar ridge were prepared histometrically and evaluated under a light microscope. Newly formed and reconstructed alveolar ridges covering the CPC were observed in all experimental sites. In the control sites, only slight newly bone formation was observed. Histomorphometrical analysis indicated that the CPC grafted group exhibited significantly (P = 0.0001) increased area and height in new bone formation compared with those of the control group. The results indicate that the CPC appears to be an effective material for alveolar ridge augmentation and may act as a space maintainer to conduct new bone formation.
authors.affiliation: Section of Periodontology, Department of Hard Tissue Engineering, Graduate School, Tokyo Medical and Dental University, Tokyo 113-8549, Japan. satoperi@tmd.ac.jp
authors.forename: I
authors.initials: I
authors.lastname: Sato
authors.forename: T
authors.initials: T
authors.lastname: Akizuki
authors.forename: S
authors.initials: S
authors.lastname: Oda
authors.forename: H
authors.initials: H
authors.lastname: Tsuchioka
authors.forename: C
authors.initials: C
authors.lastname: Hayashi
authors.forename: A A
authors.initials: AA
authors.lastname: Takasaki
authors.forename: K
authors.initials: K
authors.lastname: Mizutani
authors.forename: N
authors.initials: N
authors.lastname: Kawakatsu
authors.forename: A
authors.initials: A
authors.lastname: Kinoshita
authors.forename: I
authors.initials: I
authors.lastname: Ishikawa
authors.forename: Y
authors.initials: Y
authors.lastname: Izumi
mesh_terms: D000540:Alveolar Ridge Augmentation / Q000379:methods*; D000818:Animals; D001672:Biocompatible Materials; D001843:Bone Cements / Q000737:chemistry; D002113:Calcification, Physiologic / Q000502:physiology*; D002130:Calcium Phosphates / Q000008:administration & dosage*; D004285:Dogs; D007267:Injections; D008297:Male; D008437:Maxilla / Q000033:anatomy & histology* / Q000601:surgery
chemical_list: D001672:Biocompatible Materials; D001843:Bone Cements; D002130:Calcium Phosphates