Species distribution and in vitro susceptibility of Candida bloodstream isolates to six new and current antifungal agents in a Turkish tertiary care military hospital, recovered through 2001 and 2006.
OBJECTIVE
Species distribution and antifungal susceptibility of Candida bloodstream isolates.


METHODS
173 Candida species recovered from fungemic patients admitted to the largest tertiary-care military hospital between 2001 and 2006 in Ankara, Turkey evaluated retrospectively. Antifungal susceptibility of 95 isolates (45 Candida parapsilosis, 35 C. albicans, 7 C. tropicalis, 4 C. krusei, 3 C. glabrata, and 1 C. kefyr) was determined against fluconazole, itraconazole, voriconazole, posaconazole, caspofungin, and amphotericin B.


RESULTS
C. albicans was the most common yeast (48.0%), followed by C. parapsilosis. Almost all strains showed low minimal inhibitory concentration (MIC) values to all six antifungals tested. Only 2 of 45 C. parapsilosis isolates were resistant to fluconazole, one was susceptible in a dose-dependent manner (SDD) to itraconazole, and 14 were nonsusceptible to caspofungin.


CONCLUSIONS
Increasing prevalence of C. parapsilosis emphasizes a need for better catheter care and continuous surveillance programs.
Saracli
Mehmet A
MA
Department of Medical Microbiology, Gulhane Military Medical Academy and School of Medicine, 06018 Etlik, Ankara, Turkey.
Gumral
Ramazan
R
Gul
Hanefi C
HC
Gonlum
Ahmet
A
Yildiran
Sinasi T
ST
D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use*; D002175:Candida / Q000187:drug effects* / Q000302:isolation & purification; D002177:Candidiasis / Q000097:blood / Q000188:drug therapy*; D005260:Female; D006772:Hospitals, Military / Q000706:statistics & numerical data*; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008826:Microbial Sensitivity Tests; D014421:Turkey
D000935:Antifungal Agents