title: Elevated levels of serum antibodies against Saccharomyces cerevisiae mannan in patients with systemic lupus erythematosus.
abstract: This study was undertaken to investigate whether levels of anti-Saccharomyces cerevisiae mannan antibodies (ASCMAs), a serological marker for Crohn's disease, seronegative spondyloarthritis and Behcet's disease, also correlate with systemic lupus erythematosus (SLE) in humans. Serum samples from healthy volunteers (n = 152) and patients with SLE (n = 40) were compared for ASCMA-IgA, -IgG and -IgM levels using enzyme linked immunosorbent assays. ASCMA-IgG, but not IgM and IgA, prevalence was significantly raised in active SLE patients (57.5%) compared with healthy controls (8.5%). ASCMA-IgG levels in SLE patients during remission were relatively lower, indicating a possible correlation with disease activity. These results differ from a previous study, which did not detect a difference between ASCMA levels in SLE patients and healthy control. It remains to be evaluated whether elevated ASCMA-levels are common to all rheumatic disorders.
authors.affiliation: Department of Immunology, Peking University Health Science Center, Peking University, Beijing 100191, China.
authors.forename: H
authors.initials: H
authors.lastname: Dai
authors.forename: Z
authors.initials: Z
authors.lastname: Li
authors.forename: Y
authors.initials: Y
authors.lastname: Zhang
authors.forename: P
authors.initials: P
authors.lastname: Lv
authors.forename: X M
authors.initials: XM
authors.lastname: Gao
mesh_terms: D000293:Adolescent; D000328:Adult; D000908:Antibodies, Fungal / Q000097:blood* / Q000276:immunology; D015415:Biomarkers / Q000097:blood; D003424:Crohn Disease / Q000097:blood; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000276:immunology* / Q000503:physiopathology; D008297:Male; D008351:Mannans / Q000276:immunology*; D008875:Middle Aged; D012372:ROC Curve; D012441:Saccharomyces cerevisiae / Q000276:immunology*; D055815:Young Adult
chemical_list: D000908:Antibodies, Fungal; D015415:Biomarkers; D007074:Immunoglobulin G; D008351:Mannans