[Effects of ranitidine on pharmacokinetics of rhein from Dachengqi Decoction in rats after oral administration].
OBJECTIVE
To explore the effects of ranitidine on pharmacokinetics of rhein in rats after oral administration of Dachengqi Decoction (DCQD), a compound traditional Chinese herbal medicine.


METHODS
Twelve male Sprague-Dawley rats were divided into DCQD group and DCQD plus ranitidine group, and were orally administered with DCQD at a dose of 10 g/kg or DCQD (10 g/kg) combined with ranitidine (150 mg/kg), respectively. Blood samples were gathered after a series of time intervals. Metabolism of rhein was determined with a reversed-phase high-performance liquid chromatography with internal standard of 1, 8-dihydroxyanthraquinone and the data were analyzed with DAS 2.1 program. The pharmacokinetic parameters were compared between the two groups.


RESULTS
The pharmacokinetic parameters of rhein in the DCQD group, including peak concentration (C(max)), area under the plasma concentration-time curve (AUC), distribution phase half-life (t(1/2alpha)), elimination rate constant (K(10)) and central to peripheral transfer rate constant (K(12)), were significantly different to those in the DCQD plus ranitidine group (P<0.05, P<0.01). There were no significant differences in the other parameters between the two groups.


CONCLUSIONS
Ranitidine can influence the pharmacokinetics of rhein in rats after oral administration of DCQD.
Ren
Yan-yi
YY
Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.
Gong
Han-lin
HL
Tang
Wen-fu
WF
Wan
Mei-fua
MF
Huang
Xi
X
D000284:Administration, Oral; D000818:Animals; D000880:Anthraquinones / Q000493:pharmacokinetics*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D008297:Male; D010936:Plant Extracts / Q000737:chemistry*; D011899:Ranitidine / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D000880:Anthraquinones; D004365:Drugs, Chinese Herbal; D006635:Histamine H2 Antagonists; D010936:Plant Extracts; C477169:dachengqi decoction; D011899:Ranitidine; C020491:rhein