Direct oxidation of beta-aryl substituted aldehydes to alpha,beta-unsaturated aldehydes promoted by an o-anisidine-Pd(OAc)2 co-catalyst.
An o-anisidine-Pd(OAc)2 catalytic system for the direct co-catalytic Saegusa oxidation of beta-aryl substituted aldehydes to alpha,beta-unsaturated aldehydes has been developed. The use of o-anisidine in place of (S)-diphenylprolinol made the process more simply and cost-effective. The process not only features the use of unmodified aldehydes rather than enol silyl ethers, but also gives moderate to good yields (44-72%).
Liu
Jie
J
School of Pharmacy, East China University of Science & Technology, 130 Meilong road, Shanghai 200237, P.R. China.
Zhu
Jin
J
Jiang
Hualiang
H
Wang
Wei
W
Li
Jian
J
D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D009942:Organometallic Compounds / Q000737:chemistry*; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry*
D000447:Aldehydes; D009942:Organometallic Compounds; D010165:Palladium