title: Effects of endothelial nitric oxide synthase, interleukin-6 gene polymorphisms and asymmetric dimethylarginine levels on risk factors and lesion sites in peripheral artery disease.
abstract: This study investigated risk factors for atherosclerosis and their relationship with lesion sites. Patients (n = 160) with peripheral artery disease (PAD) completed a questionnaire regarding risk factors for PAD. Endothelial nitric oxide synthase (eNOS) and interleukin (IL)-6 gene polymorphisms and asymmetric dimethylarginine (ADMA) levels were measured. Patients with coronary artery disease had significantly higher ratios of eNOS T/C and C/C genotypes, which include the C allele, than the T/T genotype. The IL-6 gene polymorphism distribution ratios for patients with over four risk factors were significantly different compared with other patients, with a higher rate of the C/C genotype. ADMA levels did not show any significant relationship to risk factors or polymorphism. Levels were, however, slightly higher in femoral lesion sites. The results support a model in which the C/C genotype of eNOS and IL-6 gene polymorphisms promote PAD development. The eNOS C/C genotype may have an independent effect, whereas the effects of the IL-6 C/C genotype are seen in conjunction with other risk factors.
authors.affiliation: Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey. aktuygun@gmail.com
authors.forename: A K
authors.initials: AK
authors.lastname: Tuygun
authors.forename: M
authors.initials: M
authors.lastname: Keser
authors.forename: A
authors.initials: A
authors.lastname: Tuygun
authors.forename: B
authors.initials: B
authors.lastname: Ketenci
authors.forename: Y
authors.initials: Y
authors.lastname: Sensöz
authors.forename: A Y
authors.initials: AY
authors.lastname: Balci
authors.forename: A R
authors.initials: AR
authors.lastname: Karaci
authors.forename: M
authors.initials: M
authors.lastname: Kizilay
authors.forename: N
authors.initials: N
authors.lastname: Yurtseven
authors.forename: I
authors.initials: I
authors.lastname: Yekeler
mesh_terms: D001120:Arginine / Q000031:analogs & derivatives / Q000097:blood; D004252:DNA Mutational Analysis; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D008957:Models, Genetic; D052250:Nitric Oxide Synthase Type III / Q000235:genetics* / Q000378:metabolism; D016491:Peripheral Vascular Diseases / Q000097:blood / Q000235:genetics* / Q000473:pathology; D011110:Polymorphism, Genetic; D012307:Risk Factors; D011795:Surveys and Questionnaires
chemical_list: C508600:IL6 protein, human; D015850:Interleukin-6; C487735:dimethylarginine; D001120:Arginine; D052250:Nitric Oxide Synthase Type III