Identification of seven new prostate cancer susceptibility loci through a genome-wide association study.
Prostate cancer (PrCa) is the most frequently diagnosed cancer in males in developed countries. To identify common PrCa susceptibility alleles, we previously conducted a genome-wide association study in which 541,129 SNPs were genotyped in 1,854 PrCa cases with clinically detected disease and in 1,894 controls. We have now extended the study to evaluate promising associations in a second stage in which we genotyped 43,671 SNPs in 3,650 PrCa cases and 3,940 controls and in a third stage involving an additional 16,229 cases and 14,821 controls from 21 studies. In addition to replicating previous associations, we identified seven new prostate cancer susceptibility loci on chromosomes 2, 4, 8, 11 and 22 (with P = 1.6 x 10(-8) to P = 2.7 x 10(-33)).
Eeles
Rosalind A
RA
The Institute of Cancer Research, Sutton, Surrey, UK.
Kote-Jarai
Zsofia
Z
Al Olama
Ali Amin
AA
Giles
Graham G
GG
Guy
Michelle
M
Severi
Gianluca
G
Muir
Kenneth
K
Hopper
John L
JL
Henderson
Brian E
BE
Haiman
Christopher A
CA
Schleutker
Johanna
J
Hamdy
Freddie C
FC
Neal
David E
DE
Donovan
Jenny L
JL
Stanford
Janet L
JL
Ostrander
Elaine A
EA
Ingles
Sue A
SA
John
Esther M
EM
Thibodeau
Stephen N
SN
Schaid
Daniel
D
Park
Jong Y
JY
Spurdle
Amanda
A
Clements
Judith
J
Dickinson
Joanne L
JL
Maier
Christiane
C
Vogel
Walther
W
Dörk
Thilo
T
Rebbeck
Timothy R
TR
Cooney
Kathleen A
KA
Cannon-Albright
Lisa
L
Chappuis
Pierre O
PO
Hutter
Pierre
P
Zeegers
Maurice
M
Kaneva
Radka
R
Zhang
Hong-Wei
HW
Lu
Yong-Jie
YJ
Foulkes
William D
WD
English
Dallas R
DR
Leongamornlert
Daniel A
DA
Tymrakiewicz
Malgorzata
M
Morrison
Jonathan
J
Ardern-Jones
Audrey T
AT
Hall
Amanda L
AL
O'Brien
Lynne T
LT
Wilkinson
Rosemary A
RA
Saunders
Edward J
EJ
Page
Elizabeth C
EC
Sawyer
Emma J
EJ
Edwards
Stephen M
SM
Dearnaley
David P
DP
Horwich
Alan
A
Huddart
Robert A
RA
Khoo
Vincent S
VS
Parker
Christopher C
CC
Van As
Nicholas
N
Woodhouse
Christopher J
CJ
Thompson
Alan
A
Christmas
Tim
T
Ogden
Chris
C
Cooper
Colin S
CS
Southey
Melissa C
MC
Lophatananon
Artitaya
A
Liu
Jo-Fen
JF
Kolonel
Laurence N
LN
Le Marchand
Loic
L
Wahlfors
Tiina
T
Tammela
Teuvo L
TL
Auvinen
Anssi
A
Lewis
Sarah J
SJ
Cox
Angela
A
FitzGerald
Liesel M
LM
Koopmeiners
Joseph S
JS
Karyadi
Danielle M
DM
Kwon
Erika M
EM
Stern
Mariana C
MC
Corral
Roman
R
Joshi
Amit D
AD
Shahabi
Ahva
A
McDonnell
Shannon K
SK
Sellers
Thomas A
TA
Pow-Sang
Julio
J
Chambers
Suzanne
S
Aitken
Joanne
J
Gardiner
R A Frank
RA
Batra
Jyotsna
J
Kedda
Mary Anne
MA
Lose
Felicity
F
Polanowski
Andrea
A
Patterson
Briony
B
Serth
Jürgen
J
Meyer
Andreas
A
Luedeke
Manuel
M
Stefflova
Klara
K
Ray
Anna M
AM
Lange
Ethan M
EM
Farnham
Jim
J
Khan
Humera
H
Slavov
Chavdar
C
Mitkova
Atanaska
A
Cao
Guangwen
G
Easton
Douglas F
DF
D002877:Chromosomes, Human; D004198:Disease Susceptibility; D015894:Genome, Human; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms / Q000235:genetics*