title: Change of urodynamic patterns in infants with dilating vesicoureteral reflux: 3-year followup.
abstract: OBJECTIVE
  Reports concerning bladder dysfunction patterns in infants with high grade vesicoureteral reflux during the first year of life vs older children with reflux are contradictory. To describe the development of bladder function characteristics in children with congenital dilating reflux, we evaluated such infants urodynamically and followed them regularly for a 3-year period.
  
  
  METHODS
  A total of 89 males and 25 females with grade III to V dilating reflux were evaluated 3 times using videocystometry at mean ages of 6, 20 and 40 months.
  
  
  RESULTS
  Characteristics of the urodynamic pattern at 6 months could not be differentiated from normal patterns for that age, including low and normal bladder capacity, high voiding pressure levels, dyscoordination at voiding (80%) and overactivity during filling (60%). However, at 20 months the overall pattern was different, including increased bladder capacity and residual volume, normal voiding pressure, persistent overactivity during filling and dyscoordination at voiding. Bladder dysfunction was seen in 48 children (42%) at 20 months, of whom 34 primarily had high bladder capacity with incomplete emptying (dilated bladder dysfunction) and 14 had overactive bladder. Predictors for development of dilated bladder dysfunction at followup were high residual urine at 6-month examination and recurrent urinary tract infections. Recurrent infections were significantly correlated to high residual urine at all investigations and to detrusor overactivity at the 20-month examination.
  
  
  CONCLUSIONS
  Urodynamic patterns changed between the first and second year of life in patients with dilating reflux, from an immature pattern with high pressure levels to high capacity bladder with incomplete voiding. Therefore, bladder dysfunction, which was seen in 42% of patients, was only possible to diagnose after the first year of life and was mainly seen as high capacity bladder with incomplete voiding.
authors.affiliation: Pediatric Uronephrologic Center, Queen Silvia Children's Hospital, Gothenburg, Sweden.
authors.forename: Sofia
authors.initials: S
authors.lastname: Sjöström
authors.forename: Marc
authors.initials: M
authors.lastname: Bachelard
authors.forename: Rune
authors.initials: R
authors.lastname: Sixt
authors.forename: Ulla
authors.initials: U
authors.lastname: Sillén
mesh_terms: D002675:Child, Preschool; D004108:Dilatation, Pathologic; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D011446:Prospective Studies; D013997:Time Factors; D001743:Urinary Bladder / Q000503:physiopathology*; D014563:Urodynamics; D014718:Vesico-Ureteral Reflux / Q000151:congenital / Q000473:pathology* / Q000503:physiopathology*