title: Endoscopic transventricular positioning of intracystic catheter for treatment of craniopharyngioma. Technical note.
abstract: The intracystic injection of chemo- and radiotherapeutic agents was introduced for the treatment of craniopharyngioma to control tumor growth and to delay the potentially harmful effects of surgery or radiation therapy. The positioning of cyst catheters has been performed by means of direct vision, stereotactically guided insertion, and ultrasonographic and ventriculoscopic guidance. The insertion of a catheter into the cyst is not devoid of complications, with an incidence ranging up to 16%, independent of the surgical technique used. Eight patients (mean age 25.8 years) with symptomatic cystic craniopharyngioma were treated by means of an endoscopic transventricular approach for the insertion of an intracystic catheter for intratumoral therapy with interferon-alpha. A single right precoronal bur hole is made, and the frontal horn of the lateral ventricle is accessed under neuronavigation guidance. A ventricular catheter with an inserted stylet was advanced anterior to the endoscope sheath through the same cortical access as the endoscope and was guided under endoscopic view down to the cyst dome wall. The coagulated surface of the craniopharyngioma cyst was punctured and the tip of the ventricular catheter was advanced; the depth was established preoperatively on MR scans and confirmed by neuronavigation guidance. The proximal end of the cystic catheter was connected to an access chamber to be left in the subcutaneous space, and the endoscope was slowly retracted. The authors' experience favors the use of neuroendoscopic positioning of intracystic catheters as safer than open and stereotactic approaches.
authors.affiliation: Pediatric Neurosurgery Unit, Catholic University Medical School, Largo Agostino Gemelli, Rome, Italy. benedettaludovica@virgilio.it
authors.forename: Benedetta L
authors.initials: BL
authors.lastname: Pettorini
authors.forename: Gianpiero
authors.initials: G
authors.lastname: Tamburrini
authors.forename: Luca
authors.initials: L
authors.lastname: Massimi
authors.forename: Massimo
authors.initials: M
authors.lastname: Caldarelli
authors.forename: Concezio
authors.initials: C
authors.lastname: Di Rocco
mesh_terms: D000368:Aged; D002404:Catheterization; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D003397:Craniopharyngioma / Q000473:pathology / Q000628:therapy*; D005260:Female; D006801:Humans; D007155:Immunologic Factors / Q000008:administration & dosage; D015552:Injections, Intralesional; D016898:Interferon-alpha / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D044583:Neuroendoscopy; D038361:Neuronavigation; D010911:Pituitary Neoplasms / Q000473:pathology / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D007155:Immunologic Factors; D016898:Interferon-alpha