Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility.
We report a prostate cancer genome-wide association follow-on study. We discovered four variants associated with susceptibility to prostate cancer in several European populations: rs10934853[A] (OR = 1.12, P = 2.9 x 10(-10)) on 3q21.3; two moderately correlated (r2 = 0.07) variants, rs16902094[G] (OR = 1.21, P = 6.2 x 10(-15)) and rs445114[T] (OR = 1.14, P = 4.7 x 10(-10)), on 8q24.21; and rs8102476[C] (OR = 1.12, P = 1.6 x 10(-11)) on 19q13.2. We also refined a previous association signal on 11q13 with the SNP rs11228565[A] (OR = 1.23, P = 6.7 x 10(-12)). In a multivariate analysis using 22 prostate cancer risk variants typed in the Icelandic population, we estimated that carriers in the top 1.3% of the risk distribution are at a 2.5 times greater risk of developing the disease than members of the general population.
Gudmundsson
Julius
J
deCODE Genetics, Reykjavik, Iceland.
Sulem
Patrick
P
Gudbjartsson
Daniel F
DF
Blondal
Thorarinn
T
Gylfason
Arnaldur
A
Agnarsson
Bjarni A
BA
Benediktsdottir
Kristrun R
KR
Magnusdottir
Droplaug N
DN
Orlygsdottir
Gudbjorg
G
Jakobsdottir
Margret
M
Stacey
Simon N
SN
Sigurdsson
Asgeir
A
Wahlfors
Tiina
T
Tammela
Teuvo
T
Breyer
Joan P
JP
McReynolds
Kate M
KM
Bradley
Kevin M
KM
Saez
Berta
B
Godino
Javier
J
Navarrete
Sebastian
S
Fuertes
Fernando
F
Murillo
Laura
L
Polo
Eduardo
E
Aben
Katja K
KK
van Oort
Inge M
IM
Suarez
Brian K
BK
Helfand
Brian T
BT
Kan
Donghui
D
Zanon
Carlo
C
Frigge
Michael L
ML
Kristjansson
Kristleifur
K
Gulcher
Jeffrey R
JR
Einarsson
Gudmundur V
GV
Jonsson
Eirikur
E
Catalona
William J
WJ
Mayordomo
Jose I
JI
Kiemeney
Lambertus A
LA
Smith
Jeffrey R
JR
Schleutker
Johanna
J
Barkardottir
Rosa B
RB
Kong
Augustine
A
Thorsteinsdottir
Unnur
U
Rafnar
Thorunn
T
Stefansson
Kari
K
D004247:DNA / Q000235:genetics*; D004261:DNA Replication; D004198:Disease Susceptibility; D015894:Genome, Human; D055106:Genome-Wide Association Study; D006801:Humans; D007055:Iceland; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms / Q000453:epidemiology / Q000235:genetics*; D012307:Risk Factors; D044465:White People / Q000235:genetics
D004247:DNA