title: Sibutramine--its impact on health-related quality of life and depression among adult obese non-diabetic patients.
abstract: BACKGROUND
  Obesity is a multifactorial, chronic disorder that has reached epidemic proportions in most industrialised countries and is threatening to become a global epidemic.
  
  
  OBJECTIVE
  The pilot study evaluates the effect of sibutramine therapy on health-related quality of life and occurence of depression symptoms among adult obese non-diabetic patients.
  
  
  METHODS
  This study was prospective and longitudinal. It was conducted at the Department of Hygiene of Faculty of Military Health Sciences in Hradec Králove, Czech Republic. Dates were obtained during year 2007. Twenty two adult obese non-diabetic patients (6 males and 16 females) were treated with sibutramine in dose of 10 mg daily. All of these 22 patients were over 18 years old. The European Quality of Life Questionnaire--EQ-5D Version was used for evaluation of health-related quality of life. The self-assessement Zung-SDS was applied for evaluation of occurrence of depression.
  
  
  RESULTS
  The statistical evaluation demonstrated that health-related quality of life (EQ-5D score and EQ-5D visual analogue scale) presents highly significant statistical dependence on sibutramine therapy (p < 0.05). The statistical evaluation demonstrated that index of depression (SDS index) presents highly significant statistical dependence on sibutramine therapy (p < 0.05).
  
  
  CONCLUSIONS
  The results show that sibutramine therapy has a highly positive effect on health-related quality of life among adult obese non-diabetic patients. Also, the results show that sibutramine therapy has a highly positive effect on occurence of depresion symptoms among adult obese non-diabetic patients (Fig. 2, Ref. 10).
authors.affiliation: University of Defence, Faculty of Military Health Sciences, Department of Field Internal Medicine, Hradec Králové, Czech Republic. ladislav.slovacek@seznam.cz
authors.forename: L
authors.initials: L
authors.lastname: Slovacek
authors.forename: B
authors.initials: B
authors.lastname: Slovackova
authors.forename: V
authors.initials: V
authors.lastname: Pavlik
authors.forename: I
authors.initials: I
authors.lastname: Slanska
mesh_terms: D000328:Adult; D000368:Aged; D003503:Cyclobutanes / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000150:complications / Q000188:drug therapy* / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications* / Q000188:drug therapy; D011788:Quality of Life; D011795:Surveys and Questionnaires; D055815:Young Adult
chemical_list: D003503:Cyclobutanes; C058254:sibutramine