title: Burden of sleep apnea: rationale, design, and major findings of the Wisconsin Sleep Cohort study.
abstract: BACKGROUND
  Untreated sleep apnea is a prevalent but treatable condition of breathing pauses during sleep. With approximately 15% of the US population affected, understanding of the total health burden is necessary to guide policy, population initiatives, and clinical practice to reduce the prevalence of this condition.
  
  
  OBJECTIVE
  To outline the history and need for a population approach to understanding sleep apnea and provide a review of the first longitudinal population study of this disorder.
  
  
  METHODS
  The results of cross-sectional and longitudinal data from 1500 participants in the Wisconsin Sleep Cohort, initiated 2 decades ago, illustrate the population burden of sleep apnea.
  
  
  RESULTS
  The prevalence of sleep apnea is increasing with trends of increased obesity. Prospective findings from 4- to 15-year follow-up data indicate untreated sleep apnea predicts increased blood pressure, hypertension, stroke, depression, and mortality.
  
  
  CONCLUSIONS
  The high prevalence of untreated sleep apnea and links to serious morbidity and mortality underscore the population burden of this condition and the need for greater clinical recognition and strategies to reduce prevalence.
authors.affiliation: Department of Population Health Sciences, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53706, USA. tbyoung@wisc.edu
authors.forename: Terry
authors.initials: T
authors.lastname: Young
authors.forename: Mari
authors.initials: M
authors.lastname: Palta
authors.forename: Jerome
authors.initials: J
authors.lastname: Dempsey
authors.forename: Paul E
authors.initials: PE
authors.lastname: Peppard
authors.forename: F Javier
authors.initials: FJ
authors.lastname: Nieto
authors.forename: K Mae
authors.initials: KM
authors.lastname: Hla
mesh_terms: D002318:Cardiovascular Diseases / Q000453:epidemiology; D002423:Cause of Death; D003430:Cross-Sectional Studies; D003863:Depression / Q000453:epidemiology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D015994:Incidence; D008137:Longitudinal Studies; D008297:Male; D009765:Obesity / Q000453:epidemiology; D011159:Population Surveillance; D015995:Prevalence; D012307:Risk Factors; D012891:Sleep Apnea Syndromes / Q000453:epidemiology*; D020521:Stroke / Q000453:epidemiology; D014922:Wisconsin / Q000453:epidemiology