Green tea (Camellia sinensis) catechins and vascular function.
The health benefits of green tea (Camellia sinensis) catechins are becoming increasingly recognised. Amongst the proposed benefits are the maintenance of endothelial function and vascular homeostasis and an associated reduction in atherogenesis and CVD risk. The mounting evidence for the influential effect of green tea catechins on vascular function from epidemiological, human intervention and animal studies is subject to review together with exploration of the potential mechanistic pathways involved. Epigallocatechin-3-gallate, one of the most abundant and widely studied catechin found in green tea, will be prominent in the present review. Since there is a substantial inconsistency in the published data with regards to the impact of green tea catechins on vascular function, evaluation and interpretation of the inter- and intra-study variability is included. In conclusion, a positive effect of green tea catechins on vascular function is becoming apparent. Further studies in animal and cell models using physiological concentrations of catechins and their metabolites are warranted in order to gain some insight into the physiology and molecular basis of the observed beneficial effects.
Moore
Rosalind J
RJ
Department of Food Biosciences, University of Reading, Whiteknights, Reading, UK.
Jackson
Kim G
KG
Minihane
Anne M
AM
D000818:Animals; D050197:Atherosclerosis / Q000517:prevention & control; D001682:Biological Availability; D001808:Blood Vessels / Q000187:drug effects / Q000502:physiology*; D028241:Camellia sinensis / Q000737:chemistry*; D002318:Cardiovascular Diseases / Q000517:prevention & control; D002320:Cardiovascular Physiological Phenomena / Q000187:drug effects; D002392:Catechin / Q000008:administration & dosage* / Q000031:analogs & derivatives / Q000032:analysis / Q000378:metabolism / Q000493:pharmacokinetics; D004730:Endothelium, Vascular / Q000187:drug effects / Q000502:physiology; D005419:Flavonoids / Q000032:analysis; D006706:Homeostasis / Q000187:drug effects; D006801:Humans; D010636:Phenols / Q000032:analysis; D008517:Phytotherapy; D059808:Polyphenols; D015398:Signal Transduction / Q000187:drug effects; D013662:Tea / Q000737:chemistry*
D005419:Flavonoids; D010636:Phenols; D059808:Polyphenols; D013662:Tea; D002392:Catechin; C045651:epigallocatechin gallate