title: Risk of immune hemolytic anemia in children following immunization.
abstract: Several case reports have described immune hemolytic anemia (IHA) following vaccination in children. We examined the risk of IHA in the 42 days following vaccination exposure using a self-controlled case series study design. In our population-based cohort of nearly 4.5 million children in the Vaccine Safety Datalink, we identified 55 confirmed cases of new-onset IHA from 1991 through 2000. We found no association between IHA and diphtheria-pertussis-tetanus vaccination (incidence rate ratio (IRR)=0.65, 95% CI: 0.19-2.24), hepatitis B vaccination (IRR=1.73, 95% CI: 0.59-5.01), or any vaccination (IRR=1.04, 95% CI: 0.46-2.32).
authors.affiliation: The Center for Health Research, Kaiser Permanente Northwest, 3800 N Interstate Ave, Portland, OR 97227, United States. allison.naleway@kpchr.org
authors.forename: Allison L
authors.initials: AL
authors.lastname: Naleway
authors.forename: Edward A
authors.initials: EA
authors.lastname: Belongia
authors.forename: James G
authors.initials: JG
authors.lastname: Donahue
authors.forename: Burney A
authors.initials: BA
authors.lastname: Kieke
authors.forename: Jason M
authors.initials: JM
authors.lastname: Glanz
mesh_terms: D000293:Adolescent; D000743:Anemia, Hemolytic / Q000139:chemically induced* / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000009:adverse effects*; D005260:Female; D017325:Hepatitis B Vaccines / Q000009:adverse effects*; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D012306:Risk; D014481:United States / Q000453:epidemiology; D014611:Vaccination / Q000009:adverse effects*
chemical_list: D015721:Diphtheria-Tetanus-Pertussis Vaccine; D017325:Hepatitis B Vaccines