title: AP2gamma regulates basal progenitor fate in a region- and layer-specific manner in the developing cortex.
abstract: An important feature of the cerebral cortex is its layered organization, which is modulated in an area-specific manner. We found that the transcription factor AP2gamma regulates laminar fate in a region-specific manner. Deletion of AP2gamma (also known as Tcfap2c) during development resulted in a specific reduction of upper layer neurons in the occipital cortex, leading to impaired function and enhanced plasticity of the adult visual cortex. AP2gamma functions in apical progenitors, and its absence resulted in mis-specification of basal progenitors in the occipital cortex at the time at which upper layer neurons were generated. AP2gamma directly regulated the basal progenitor fate determinants Math3 (also known as Neurod4) and Tbr2, and its overexpression promoted the generation of layer II/III neurons in a time- and region-specific manner. Thus, AP2gamma acts as a regulator of basal progenitor fate, linking regional and laminar specification in the mouse developing cerebral cortex.
authors.affiliation: Helmholtz Center Munich, German Research Center for Environmental Health, Institute for Stem Cell Research, Neuherberg/Munich, Germany. luisapinto@ecsaude.uminho.pt [corrected]
authors.forename: Luisa
authors.initials: L
authors.lastname: Pinto
authors.forename: Daniela
authors.initials: D
authors.lastname: Drechsel
authors.forename: Marie-Theres
authors.initials: MT
authors.lastname: Schmid
authors.forename: Jovica
authors.initials: J
authors.lastname: Ninkovic
authors.forename: Martin
authors.initials: M
authors.lastname: Irmler
authors.forename: Monika S
authors.initials: MS
authors.lastname: Brill
authors.forename: Laura
authors.initials: L
authors.lastname: Restani
authors.forename: Laura
authors.initials: L
authors.lastname: Gianfranceschi
authors.forename: Chiara
authors.initials: C
authors.lastname: Cerri
authors.forename: Susanne N
authors.initials: SN
authors.lastname: Weber
authors.forename: Victor
authors.initials: V
authors.lastname: Tarabykin
authors.forename: Kristin
authors.initials: K
authors.lastname: Baer
authors.forename: François
authors.initials: F
authors.lastname: Guillemot
authors.forename: Johannes
authors.initials: J
authors.lastname: Beckers
authors.forename: Nada
authors.initials: N
authors.lastname: Zecevic
authors.forename: Colette
authors.initials: C
authors.lastname: Dehay
authors.forename: Matteo
authors.initials: M
authors.lastname: Caleo
authors.forename: Hubert
authors.initials: H
authors.lastname: Schorle
authors.forename: Magdalena
authors.initials: M
authors.lastname: Götz
mesh_terms: D000328:Adult; D000818:Animals; D001973:Bromodeoxyuridine / Q000378:metabolism; D002452:Cell Count / Q000379:methods; D002454:Cell Differentiation / Q000502:physiology*; D002461:Cell Line, Transformed; D002540:Cerebral Cortex / Q000166:cytology / Q000196:embryology / Q000254:growth & development; D004622:Embryo, Mammalian; D053595:Embryonic Stem Cells / Q000502:physiology*; D005074:Evoked Potentials, Visual / Q000235:genetics / Q000502:physiology; D005136:Eye Proteins / Q000235:genetics / Q000378:metabolism; D005333:Fetus; D017353:Gene Deletion; D018507:Gene Expression Regulation, Developmental / Q000235:genetics / Q000502:physiology; D049452:Green Fluorescent Proteins / Q000235:genetics; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D017874:Immediate-Early Proteins / Q000235:genetics; D019394:Ki-67 Antigen / Q000378:metabolism; D008252:Macaca fascicularis; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D055495:Neurogenesis / Q000502:physiology*; D000071841:PAX6 Transcription Factor; D051761:Paired Box Transcription Factors / Q000235:genetics / Q000378:metabolism; D010775:Photic Stimulation / Q000379:methods; D012333:RNA, Messenger / Q000378:metabolism; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism; D020825:T-Box Domain Proteins / Q000378:metabolism; D050656:Transcription Factor AP-2 / Q000235:genetics / Q000502:physiology*; D014157:Transcription Factors / Q000235:genetics; D014162:Transfection / Q000379:methods; D025521:Tumor Suppressor Proteins / Q000235:genetics; D000099260:Empty Spiracles Homeobox Proteins
chemical_list: D001973:Bromodeoxyuridine; D005136:Eye Proteins; D049452:Green Fluorescent Proteins; D018398:Homeodomain Proteins; D017874:Immediate-Early Proteins; D019394:Ki-67 Antigen; D000071841:PAX6 Transcription Factor; D051761:Paired Box Transcription Factors; D012333:RNA, Messenger; D012097:Repressor Proteins; D020825:T-Box Domain Proteins; D050656:Transcription Factor AP-2; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins; D000099260:Empty Spiracles Homeobox Proteins; C489435:Btg2 protein, mouse; C491198:Eomes protein, mouse; C000605730:PAX6 protein, human; C000605732:Pax6 protein, mouse