[Does dilution have an impact on cosmetic results with BoNT/A? Complex-protein-free BoNT/A for treatment of glabella lines].
BACKGROUND
In this 2-armed, randomized study we investigated the efficacy and tolerability of complex-protein-free botulinum neurotoxin type A (BoNT/A), applied in two different dilution volumes for treatment of glabellar lines.


METHODS
40 patients with grade 2-3 glabellar lines (Facial Wrinkle Scale) received treatment with 25U BoNT/A (Xeomin). 100U of botulinum neurotoxin were diluted in 2.5 ml (group I) or 4 ml sodium chloride solution (group II). Responders showed an improvement in the wrinkle score (independent rater) of at least one point. RESULTS. Response rates two weeks after treatment were 100% / 89.5%, at 3 months 84.2% / 64.7% and at 4 months 53.3% / 61.5% (groups I / II respectively). There was no significant difference between the two dilutions.


CONCLUSIONS
Complex-protein-free botulinum neurotoxin type A in both dilutions effectively reduced severity of glabellar lines. There was no statistically significant difference in efficacy between the two dilutions.
Prager
W
W
Dermatologikum Hamburg. prager@dermatologikum.de
Zschocke
I
I
Reich
C
C
Brocatti
L
L
Henning
K
K
Steinkraus
V
V
D000293:Adolescent; D000328:Adult; D000368:Aged; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage* / Q000737:chemistry*; D016895:Culture Media, Serum-Free / Q000737:chemistry; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015595:Skin Aging / Q000187:drug effects* / Q000473:pathology*; D012995:Solubility; D016896:Treatment Outcome; D055815:Young Adult
D016895:Culture Media, Serum-Free; D019274:Botulinum Toxins, Type A