Haplotypes and 5A/6A polymorphism of the matrix metalloproteinase-3 gene in coronary disease: case-control study and a meta-analysis.
OBJECTIVE
Matrix metalloproteinase-3 and its gene, MMP3, have been implicated in atherosclerotic diseases of coronary arteries. We conducted a haplotype analysis to examine the role of common variation of MMP3 in myocardial infarction (MI) and a meta-analysis to combine available evidence on the association between the 5A/6A polymorphism (rs3025058) and coronary diseases.


RESULTS
Genotype distributions of haplotype-tagging single nucleotide polymorphisms (rs522616, rs650108, rs569444, rs635746) and rs3025058 were not significantly different between a group with MI (n=3657) and a control group (n=1211) (p> or =0.24). Five major haplotypes were established, and their frequencies were not substantially different between the case and control groups (p> or =0.11). In a meta-analysis of 15 studies (10,061 cases, 8048 controls), the overall risk of coronary disease was not different between the carriers of the 5A allele and 6A6A genotype of rs3025058 (OR, 1.00; 95% CI, 0.85-1.19). Moderate trends of a reduced risk in the 5A allele carriers of European ancestry (OR, 0.87; 95% CI, 0.76-1.00) and an increased risk in the 5A allele carriers from East Asia (OR, 1.33; 95% CI, 0.94-1.90) were observed.


CONCLUSIONS
Individual polymorphisms and haplotypes of MMP3 were not associated with MI in a German case-control study. Evidence was obtained to suggest different risk effects of rs3025058 between Europeans and East Asians.
Koch
Werner
W
Deutsches Herzzentrum München and 1. Medizinische Klinik, Klinikum rechts der Isar, Technische Universität München, Lazarettstrasse 36, Munich, Germany. wkoch@dhm.mhn.de
de Waha
Antoinette
A
Hoppmann
Petra
P
Schömig
Albert
A
Kastrati
Adnan
A
D016022:Case-Control Studies; D003327:Coronary Disease / Q000235:genetics*; D005260:Female; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D008297:Male; D019278:Matrix Metalloproteinase 3 / Q000235:genetics*; D008875:Middle Aged; D009203:Myocardial Infarction / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
D019278:Matrix Metalloproteinase 3