Antiprotozoal activity of betulinic acid derivatives.
Betulinic acid (1), isolated from the crude extract of the leaves of Pentalinon andrieuxii (Apocynaceae), together with betulinic acid acetate (2), betulonic acid (3), betulinic acid methyl ester (4), and betulin (5) were evaluated for their antiprotozoal activity. The results showed that modifying the C-3 position increases leishmanicidal activity while modification of the C-3 and C-28 positions decreases trypanocidal activity.
Domínguez-Carmona
D B
DB
Unidad de Biotecnología, Centro de Investigación Científica de Yucatán, Calle 43, No. 130, Col. Chuburná, Mérida, Yucatán 97200, México.
Escalante-Erosa
F
F
García-Sosa
K
K
Ruiz-Pinell
G
G
Gutierrez-Yapu
D
D
Chan-Bacab
M J
MJ
Giménez-Turba
A
A
Peña-Rodríguez
L M
LM
D000981:Antiprotozoal Agents / Q000138:chemical synthesis / Q000302:isolation & purification / Q000494:pharmacology*; D029062:Apocynaceae / Q000737:chemistry*; D007891:Leishmania / Q000187:drug effects*; D015394:Molecular Structure; D021261:Parasitic Sensitivity Tests; D053978:Pentacyclic Triterpenes; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves; D010963:Plasmodium falciparum / Q000187:drug effects*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014345:Trypanosoma / Q000187:drug effects*; D000094062:Betulinic Acid
D000981:Antiprotozoal Agents; D053978:Pentacyclic Triterpenes; D010936:Plant Extracts; D014315:Triterpenes; D000094062:Betulinic Acid