title: Effect of Saccharomyces cerevisiae fermentation product on immune functions of broilers challenged with Eimeria tenella.
abstract: Three hundred sixty 1-d-old male Arbor Acres broilers were randomly allotted to 6 groups with a 2x3 factorial arrangement of treatments. Three supplemental levels (0, 0.25, and 0.50%) of Saccharomyces cerevisiae fermentation product (XP) were fed to control and Eimeria tenella-infected broilers. Growth performance and immune response criteria were measured after coccidian infection. Broiler ADG was lowered (P<0.01) by coccidian infection and improved by XP supplementation (P=0.04). Supplementation of XP increased CD3+, CD4+, and CD8+ T-lymphocyte counts (P<0.05) and the ratio CD4+:CD8+ in blood (P=0.06) and spleen (P=0.04) as well as ileum intraepithelial lymphocyte count, cecal tonsil secretory IgA counts, serum lysozyme content (P<0.01), and albumin:globulin ratio (P=0.02). These results suggest that dietary XP supplementation could improve immune function and growth performance in coccidia-infected broilers.
authors.affiliation: Feed Research Institute, Chinese Academy of Agricultural Sciences & Key Laboratory of Feed Biotechnology, Ministry of Agriculture of China, Beijing 100081, China.
authors.forename: J
authors.initials: J
authors.lastname: Gao
authors.forename: H J
authors.initials: HJ
authors.lastname: Zhang
authors.forename: S G
authors.initials: SG
authors.lastname: Wu
authors.forename: S H
authors.initials: SH
authors.lastname: Yu
authors.forename: I
authors.initials: I
authors.lastname: Yoon
authors.forename: D
authors.initials: D
authors.lastname: Moore
authors.forename: Y P
authors.initials: YP
authors.lastname: Gao
authors.forename: H J
authors.initials: HJ
authors.lastname: Yan
authors.forename: G H
authors.initials: GH
authors.lastname: Qi
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000097:blood; D002432:Cecum / Q000469:parasitology; D002645:Chickens; D003048:Coccidiosis / Q000276:immunology / Q000469:parasitology / Q000662:veterinary*; D016786:Eimeria tenella / Q000276:immunology*; D007082:Ileum / Q000469:parasitology; D007070:Immunoglobulin A / Q000032:analysis; D007411:Intestinal Diseases, Parasitic / Q000276:immunology / Q000469:parasitology / Q000662:veterinary*; D008297:Male; D009113:Muramidase / Q000097:blood; D011201:Poultry Diseases / Q000276:immunology / Q000469:parasitology*; D011897:Random Allocation; D012441:Saccharomyces cerevisiae / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology / Q000469:parasitology; D013601:T-Lymphocytes / Q000276:immunology / Q000469:parasitology
chemical_list: D015703:Antigens, CD; D007070:Immunoglobulin A; D009113:Muramidase