Synthesis and evaluation of 9-aminoacridines derived from benzyne click chemistry.
A small set of 9-aminoacridine-3- and 4-carboxamides were synthesized efficiently using the benzyne/azide click chemistry. The products bind to duplex DNA but have different antitumour activity in the HL60 cell line.
Howell
Lesley A
LA
School of Pharmacy, University of East Anglia, Norwich NR4 7TJ, United Kingdom.
Howman
Aaron
A
O'Connell
Maria A
MA
Mueller
Anja
A
Searcey
Mark
M
D000585:Aminacrine / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D001555:Benzene Derivatives / Q000737:chemistry*; D045744:Cell Line, Tumor; D004247:DNA / Q000737:chemistry; D004264:DNA Topoisomerases, Type I / Q000378:metabolism; D006801:Humans; D059004:Topoisomerase I Inhibitors
D000970:Antineoplastic Agents; D001555:Benzene Derivatives; D059004:Topoisomerase I Inhibitors; C524146:benzyne; D000585:Aminacrine; D004247:DNA; D004264:DNA Topoisomerases, Type I