title: Regulation of pathogenesis and immunity in helminth infections.
abstract: Helminths are multicellular eukaryotic parasites that infect over one quarter of the world's population. Through coevolution with the human immune system, these organisms have learned to exploit immunoregulatory pathways, resulting in asymptomatic tolerance of infections in many individuals. When infections and the resulting immune responses become dysregulated, however, acute and chronic pathologies often develop. A recent international meeting focused on how these parasites modulate host immunity and how control of parasitic and immunopathological disease might be achieved.
authors.affiliation: Centre for Immunity, Infection and Evolution, Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, Scotland, UK. rick.maizels@ed.ac.uk
authors.forename: Rick M
authors.initials: RM
authors.lastname: Maizels
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Pearce
authors.forename: David
authors.initials: D
authors.lastname: Artis
authors.forename: Maria
authors.initials: M
authors.lastname: Yazdanbakhsh
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Wynn
mesh_terms: D000818:Animals; D015551:Autoimmunity; D001402:B-Lymphocytes / Q000276:immunology; D006373:Helminthiasis / Q000276:immunology*; D006790:Host-Parasite Interactions; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology; D020381:Interleukin-17 / Q000276:immunology; D015847:Interleukin-4 / Q000276:immunology; D008262:Macrophage Activation; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; D020381:Interleukin-17; C486574:RETNLB protein, human; D015847:Interleukin-4