Improving bone density at the rotator cuff footprint increases supraspinatus tendon failure stress in a rat model.
The purpose of this study was to investigate whether supraspinatus tendon failure stress at the footprint can increase by improving the bone density at the rotator cuff footprint in a rat model. Bilateral ovariectomies were performed in twenty-four 4-month-old Sprague-Dawley rats. Half received bisphosphonate (zoledronic acid) and the other half received no treatment (OVX + ZOM and OVX, respectively). Twelve additional rats did not undergo ovariectomy or receive bisphosphonate treatment (CON). All rats were sacrificed at 7 months of age. Quantitative micro-computed tomography was used to assess bone density in the proximal humerus. A series of stress-relaxation tests were performed to assess stiffness and failure stress of the supraspinatus tendon. Bone density in OVX + ZOM was significantly higher at the rotator cuff footprint when compared to CON and OVX rats (p < 0.0001). The supraspinatus tendons in the OVX group were significantly stiffer when compared to the CON and OVX + ZOM groups (p < 0.05). The failure stress of the OVX + ZOM group was significantly greater than the CON and OVX groups (22.89 +/- 4.43 MPa vs. 18.36 +/- 3.16 and 17.70 +/- 4.92, respectively). In conclusion, improving the bone density at the rotator cuff footprint enhances failure stress of the suprapinatus tendon.
Cadet
Edwin R
ER
Center of Shoulder, Elbow, and Sports Medicine, Department of Orthopaedic Surgery, Columbia University Medical Center, 622 West 168th Street, PH 11th Floor, New York, New York 10032, USA. ec2195@columbia.edu
Vorys
George C
GC
Rahman
Ra'Kerry
R
Park
Sang-Hyun
SH
Gardner
Thomas R
TR
Lee
Francis Y
FY
Levine
William N
WN
Bigliani
Louis U
LU
Ahmad
Christopher S
CS
D000818:Animals; D001696:Biomechanical Phenomena; D015519:Bone Density / Q000187:drug effects; D050071:Bone Density Conservation Agents / Q000494:pharmacology; D004164:Diphosphonates / Q000494:pharmacology; D005260:Female; D006811:Humerus / Q000000981:diagnostic imaging / Q000378:metabolism*; D007093:Imidazoles / Q000494:pharmacology; D009929:Organ Size; D010052:Ovariectomy; D051381:Rats; D017207:Rats, Sprague-Dawley; D017006:Rotator Cuff; D013314:Stress, Mechanical; D013710:Tendons / Q000473:pathology / Q000503:physiopathology*; D014057:Tomography, X-Ray Computed / Q000379:methods; D014599:Uterus / Q000473:pathology; D000077211:Zoledronic Acid
D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D007093:Imidazoles; D000077211:Zoledronic Acid