title: Measuring health-related quality of life in population-based studies of coronary heart disease: comparing six generic indexes and a disease-specific proxy score.
abstract: OBJECTIVE
  To compare HRQoL differences with CHD in generic indexes and a proxy CVD-specific score in a nationally representative sample of U.S. adults.
  
  
  METHODS
  The National Health Measurement Study, a cross-sectional random-digit-dialed telephone survey of adults aged 35-89, administered the EQ-5D, QWB-SA, HUI2, HUI3, SF-36v2 (yielding PCS, MCS, and SF-6D), and HALex. Analyses compared 3,350 without CHD (group 1), 265 with CHD not taking chest pain medication (group 2), and 218 with CHD currently taking chest pain medication (group 3), with and without adjustment for demographic variables and comorbidities. Data on 154 patients from heart failure clinics were used to construct a proxy score utilizing generic items probing CVD symptoms.
  
  
  RESULTS
  Mean scores differed between CHD groups for all indexes with and without adjustment (P < 0.0001 for all except MCS P = 0.018). Unadjusted group 3 versus 1 differences were about three times larger than for group 2 versus 1. Standardized differences for the proxy score were similar to those for generic indexes, and were about 1.0 for all except MCS for group 3 versus 1.
  
  
  CONCLUSIONS
  Generic indexes capture differences in HRQoL in population-based studies of CHD similarly to a score constructed from questions probing CVD-specific symptoms.
authors.affiliation: Department of Population Health Sciences, University of Wisconsin-Madison, WARF Office Building Room 707, 610 Walnut Street, Madison, WI 53726, USA.
authors.forename: Noelle C
authors.initials: NC
authors.lastname: Garster
authors.forename: Mari
authors.initials: M
authors.lastname: Palta
authors.forename: Nancy K
authors.initials: NK
authors.lastname: Sweitzer
authors.forename: Robert M
authors.initials: RM
authors.lastname: Kaplan
authors.forename: Dennis G
authors.initials: DG
authors.lastname: Fryback
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003327:Coronary Disease / Q000523:psychology*; D005260:Female; D006304:Health Status; D006801:Humans; D007407:Interviews as Topic; D008297:Male; D008875:Middle Aged; D019727:Proxy; D011788:Quality of Life / Q000523:psychology*; D011795:Surveys and Questionnaires; D014481:United States