Alotamide A, a novel neuropharmacological agent from the marine cyanobacterium Lyngbya bouillonii.
Alotamide A (1), a structurally intriguing cyclic depsipeptide, was isolated from the marine mat-forming cyanobacterium Lyngbya bouillonii collected in Papua New Guinea. It features three contiguous peptidic residues and an unsaturated heptaketide with oxidations and methylations unlike those found in any other marine cyanobacterial metabolite. Pure alotamide A (1) displays an unusual calcium influx activation profile in murine cerebrocortical neurons with an EC50 of 4.18 microM.
Soria-Mercado
Irma E
IE
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92037, USA.
Pereira
Alban
A
Cao
Zhengyu
Z
Murray
Thomas F
TF
Gerwick
William H
WH
D000818:Animals; D002118:Calcium / Q000378:metabolism; D000458:Cyanobacteria / Q000737:chemistry*; D047630:Depsipeptides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D051379:Mice; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D009480:Neuropharmacology; D009792:Oceans and Seas
D047630:Depsipeptides; C545743:alotamide A; D002118:Calcium