title: Recombinant Sindbis virus vectors designed to express protective antigen of Bacillus anthracis protect animals from anthrax and display synergy with ciprofloxacin.
abstract: Recombinant Sindbis viruses were engineered to express alternative forms of the protective antigen (PA) of Bacillus anthracis. The recombinant viruses induced PA-specific immunoglobulin G and neutralizing antibodies in Swiss Webster mice. Vaccination with the recombinant viruses induced immunity that offered some protection from a lethal Ames strain spore challenge and synergized the protective effects of ciprofloxacin.
authors.affiliation: Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas 77555-1070, USA. JohnM.Thomas@utsouthwestern.edu
authors.forename: John M
authors.initials: JM
authors.lastname: Thomas
authors.forename: Scott T
authors.initials: ST
authors.lastname: Moen
authors.forename: Bryan T
authors.initials: BT
authors.lastname: Gnade
authors.forename: Diego A
authors.initials: DA
authors.lastname: Vargas-Inchaustegui
authors.forename: Sheri M
authors.initials: SM
authors.lastname: Foltz
authors.forename: Giovanni
authors.initials: G
authors.lastname: Suarez
authors.forename: Hans W
authors.initials: HW
authors.lastname: Heidner
authors.forename: Rolf
authors.initials: R
authors.lastname: König
authors.forename: Ashok K
authors.initials: AK
authors.lastname: Chopra
authors.forename: Johnny W
authors.initials: JW
authors.lastname: Peterson
mesh_terms: D000818:Animals; D000881:Anthrax / Q000517:prevention & control*; D022122:Anthrax Vaccines / Q000235:genetics / Q000276:immunology*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000907:Antibodies, Bacterial / Q000097:blood; D057134:Antibodies, Neutralizing / Q000097:blood; D000942:Antigens, Bacterial / Q000235:genetics / Q000276:immunology*; D001408:Bacillus anthracis / Q000235:genetics*; D001427:Bacterial Toxins / Q000235:genetics / Q000276:immunology*; D002939:Ciprofloxacin / Q000627:therapeutic use*; D005822:Genetic Vectors; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D051379:Mice; D012845:Sindbis Virus / Q000235:genetics* / Q000276:immunology; D016019:Survival Analysis; D014614:Vaccines, Synthetic / Q000235:genetics / Q000276:immunology
chemical_list: D022122:Anthrax Vaccines; D000900:Anti-Bacterial Agents; D000907:Antibodies, Bacterial; D057134:Antibodies, Neutralizing; D000942:Antigens, Bacterial; D001427:Bacterial Toxins; D007074:Immunoglobulin G; D014614:Vaccines, Synthetic; C030325:anthrax toxin; D002939:Ciprofloxacin