Synthesis and preliminary biological evaluations of [18F]-1-deoxy-1-fluoro-scyllo-inositol.
A novel PET radiotracer, [18F]-1-deoxy-1-fluoro-scyllo-inositol, was synthesized via a one-pot reaction in 16 +/- 3% uncorrected radiochemical yield within 80 minutes; although this compound revealed low brain penetration it shows promise in rodent tumour models for breast cancer imaging.
Vasdev
Neil
N
PET Centre, Centre for Addiction and Mental Health, 250 College St., Toronto, ON, Canada M5T 1R8. neil.vasdev@camhpet.ca
Chio
Jason
J
van Oosten
Erik M
EM
Nitz
Mark
M
McLaurin
Joanne
J
Vines
Douglass C
DC
Houle
Sylvain
S
Reilly
Raymond M
RM
Wilson
Alan A
AA
D000818:Animals; D045744:Cell Line, Tumor; D005462:Fluorine Radioisotopes / Q000737:chemistry; D006801:Humans; D007294:Inositol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D008297:Male; D051379:Mice; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D013237:Stereoisomerism; D014183:Transplantation, Heterologous
C544911:(18F)-1-deoxy-1-fluoro-scyllo-inositol; D005462:Fluorine Radioisotopes; D019275:Radiopharmaceuticals; D007294:Inositol