Roles of calcitonin gene-related peptide and its receptors in pain-related behavioral responses in the central nervous system.
Calcitonin gene-related peptide (CGRP) is a 37 amino-acid peptide, which is widely distributed in peripheral and central nervous system. There are two types of CGRP receptors, CGRP receptor 1 and CGRP receptor 2. It is known that CGRP plays important roles in multiple physiological processes. Studies demonstrate that CGRP and CGRP receptors are involved in the transmission and modulation of pain information in peripheral and central nervous system. CGRP8-37, a specific antagonist for CGRP receptor 1, is widely used to differentiate the two typical CGRP receptors. There are two ambiguous points about the effects of CGRP and CGRP8-37 on pain-related behavioral responses. The first is the effects of exogenous CGRP and CGRP8-37 on the transmission and regulation of pain information in the spinal cord. The second is the effects of these peptides in pain modulation at super-spinal levels. The specific goal of this review is to summarize the roles of CGRP, CGRP8-37 and CGRP receptors in pain-related behavioral responses in the central nervous system.
Yu
Long-Chuan
LC
Neurobiology Laboratory, College of Life Sciences, Peking University, Beijing 100871, People's Republic of China. yulc@pku.edu.cn
Hou
Jun-Feng
JF
Fu
Feng-Hua
FH
Zhang
Ying-Xin
YX
D000818:Animals; D001921:Brain / Q000502:physiology / Q000503:physiopathology; D015740:Calcitonin Gene-Related Peptide / Q000502:physiology*; D006801:Humans; D009619:Nociceptors / Q000502:physiology*; D010146:Pain / Q000503:physiopathology*; D018015:Receptors, Calcitonin Gene-Related Peptide / Q000502:physiology*; D013116:Spinal Cord / Q000502:physiology / Q000503:physiopathology
D018015:Receptors, Calcitonin Gene-Related Peptide; D015740:Calcitonin Gene-Related Peptide