Rodent quality assurance testing: use of sentinel animal systems.
The ability to produce unique strains of genetically engineered mice has revolutionized biomedical research, but has also complicated the maintenance of "clean" facilities through an increase in the movement of animals between facilities and the production of immunodeficient strains. The authors discuss the use of sentinel and quarantine programs to minimize disease transmission between laboratory mice.
Lipman
Neil S
NS
Research Animal Resource Center, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. lipmann@mskcc.org
Homberger
Felix R
FR
D000820:Animal Diseases / Q000175:diagnosis / Q000517:prevention & control* / Q000635:transmission; D000822:Animal Husbandry / Q000379:methods* / Q000592:standards; D000818:Animals; D004196:Disease Outbreaks / Q000517:prevention & control / Q000662:veterinary*; D007756:Laboratory Animal Science / Q000379:methods* / Q000592:standards; D051379:Mice; D011785:Quality Assurance, Health Care; D011790:Quarantine / Q000592:standards / Q000662:veterinary; D012637:Security Measures / Q000592:standards; D018571:Sentinel Surveillance / Q000662:veterinary*