title: Amygdala volumes in childhood absence epilepsy.
abstract: Abnormal amygdala volumes in pediatric mood-anxiety disorders and attention deficit hyperactivity disorder (ADHD), as well as high rates of these diagnoses in childhood absence epilepsy (CAE), prompted this study of amygdala volume in CAE. Twenty-six children with CAE and 23 normal children, aged 6.6-15.8 years, underwent MRI at 1.5 T. The tissue imaged with MRI was segmented, and amygdala volumes were obtained by manual tracings. There were no significant amygdala volume differences between the CAE and normal groups. Within the CAE group, however, the children with ADHD had significantly smaller amygdala volumes than the subjects with CAE with no psychopathology and those with mood/anxiety diagnoses. There was also a significant relationship between higher seizure frequency and greater amygdala asymmetry in the epilepsy group. Given ongoing development of the amygdala during late childhood and adolescence, despite the lack of significant group differences in amygdala volumes, the association of amygdala volume abnormalities with ADHD and seizure frequency implies a possible impact of the disorder on amygdala development and CAE-associated comorbidities, such as ADHD.
authors.affiliation: Department of Psychiatry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA. ayeletsc@gmail.com
authors.forename: Ayelet
authors.initials: A
authors.lastname: Schreibman Cohen
authors.forename: Melita
authors.initials: M
authors.lastname: Daley
authors.forename: Prabha
authors.initials: P
authors.lastname: Siddarth
authors.forename: Jennifer
authors.initials: J
authors.lastname: Levitt
authors.forename: Ingrid K
authors.initials: IK
authors.lastname: Loesch
authors.forename: Lori
authors.initials: L
authors.lastname: Altshuler
authors.forename: Ronald
authors.initials: R
authors.lastname: Ly
authors.forename: W Donald
authors.initials: WD
authors.lastname: Shields
authors.forename: Suresh
authors.initials: S
authors.lastname: Gurbani
authors.forename: Rochelle
authors.initials: R
authors.lastname: Caplan
mesh_terms: D000293:Adolescent; D000679:Amygdala / Q000002:abnormalities* / Q000473:pathology*; D001289:Attention Deficit Disorder with Hyperactivity / Q000473:pathology; D001931:Brain Mapping; D057189:Checklist / Q000379:methods; D002648:Child; D004832:Epilepsy, Absence / Q000473:pathology*; D005260:Female; D007839:Functional Laterality; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D011569:Psychiatric Status Rating Scales; D012720:Severity of Illness Index; D014888:Wechsler Scales