Changes in IGF-I, IGFBP-3 and ghrelin levels after adenotonsillectomy in children with sleep disordered breathing.
OBJECTIVE
The aim of this study was to determine the changes in insulin-like growth factor-I (IGF-I), insulin-like growth factor binding protein-3 (IGFBP-3) and ghrelin levels following adenotonsillectomy (T&A) in children with sleep disordered breathing (SDB).


METHODS
Forty children (mean age 4.85+/-2.15 years) clinically diagnosed with adenotonsillar hypertrophy (ATH) related SDB were enrolled. All children underwent T&A. Serum levels of IGF-I, IGFBP-3 and ghrelin were measured before and 6 months after T&A.


RESULTS
Serum levels of IGF-I and IGFBP-3 were significantly higher after T&A (p<0.001). Serum ghrelin levels showed a significant decrease after T&A (p<0.001).


CONCLUSIONS
Children with ATH related SDB who underwent T&A showed significant increases in IGF-I and IGFBP-3 levels indicating an increase in diurnal growth hormone secretion as well as a significant decrese in ghrelin levels indicating an increased oral food intake in the postoperative period.
Gümüssoy
Murat
M
Dept of Otolaryngology, Ondokuz Mayis University School of Medicine, Samsun, Turkey.
Atmaca
Sinan
S
Bilgici
Birsen
B
Unal
Recep
R
D000233:Adenoidectomy / Q000379:methods*; D000234:Adenoids / Q000473:pathology / Q000601:surgery; D015415:Biomarkers / Q000097:blood; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D054439:Ghrelin / Q000097:blood*; D006801:Humans; D006984:Hypertrophy / Q000473:pathology / Q000601:surgery; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008297:Male; D014066:Palatine Tonsil / Q000473:pathology / Q000601:surgery; D011182:Postoperative Care; D011300:Preoperative Care; D011446:Prospective Studies; D012891:Sleep Apnea Syndromes / Q000097:blood* / Q000209:etiology* / Q000601:surgery; D014068:Tonsillectomy / Q000379:methods*; D016896:Treatment Outcome
D015415:Biomarkers; D054439:Ghrelin; D018972:Insulin-Like Growth Factor Binding Protein 3; D007334:Insulin-Like Growth Factor I