title: Factors associated with non-penetrating deep sclerectomy failure in controlling intraocular pressure.
abstract: OBJECTIVE
  To identify factors related to non-penetrating deep sclerectomy (NPDS) failure in controlling intraocular pressure (IOP).
  
  
  METHODS
  A case-control study was performed through a logistic regression modelling. All cases and controls had at least 2 years of follow-up. Cases comprised eyes that had undergone an NPDS and presented an end-point IOP > 18 mmHg; controls consisted of eyes that had undergone an NPDS and achieved an end-point IOP < 18 mmHg without medication. Cases and controls were paired by sex and postoperative time. The following independent variables were tested: race, previous ocular surgery, number of topical medications prior to surgery, age, preoperative IOP, severity of glaucomatous visual field loss, use of mitomycin C (MMC), YAG laser goniopuncture and IOP in the first day after surgery.
  
  
  RESULTS
  Two hundred and sixty-nine eyes were studied (136 cases and 133 controls). Absence of intraoperative MMC and high preoperative IOP were related to an end-point IOP > 18 mmHg after 2 years of follow-up.
  
  
  CONCLUSIONS
  Two factors seem to be associated to NPDS failure: the absence of intraoperative MMC and preoperative IOP.
authors.affiliation: Federal University of Juiz de Fora, Brazil. palettaguedes@yahoo.com
authors.forename: Ricardo A P
authors.initials: RA
authors.lastname: Guedes
authors.forename: Vanessa M P
authors.initials: VM
authors.lastname: Guedes
authors.forename: Alfredo
authors.initials: A
authors.lastname: Chaoubah
mesh_terms: D000368:Aged; D000959:Antihypertensive Agents / Q000008:administration & dosage; D016022:Case-Control Studies; D005500:Follow-Up Studies; D005902:Glaucoma, Open-Angle / Q000188:drug therapy / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure; D008875:Middle Aged; D012307:Risk Factors; D012590:Sclera / Q000601:surgery*; D012599:Sclerostomy; D014065:Tonometry, Ocular; D017211:Treatment Failure; D058609:Visual Field Tests
chemical_list: D000959:Antihypertensive Agents