Cholera transmission: the host, pathogen and bacteriophage dynamic.
Zimbabwe offers the most recent example of the tragedy that befalls a country and its people when cholera strikes. The 2008-2009 outbreak rapidly spread across every province and brought rates of mortality similar to those witnessed as a consequence of cholera infections a hundred years ago. In this Review we highlight the advances that will help to unravel how interactions between the host, the bacterial pathogen and the lytic bacteriophage might propel and quench cholera outbreaks in endemic settings and in emergent epidemic regions such as Zimbabwe.
Nelson
Eric J
EJ
Howard Hughes Medical Institute, Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA.
Harris
Jason B
JB
Morris
J Glenn
JG
Calderwood
Stephen B
SB
Camilli
Andrew
A
D000818:Animals; D001435:Bacteriophages / Q000502:physiology*; D002771:Cholera / Q000453:epidemiology / Q000276:immunology / Q000382:microbiology / Q000635:transmission*; D005618:Fresh Water / Q000382:microbiology; D006801:Humans; D014734:Vibrio cholerae / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity* / Q000821:virology*; D015030:Zimbabwe / Q000453:epidemiology