title: KL-6 mucin in metastatic liver cancer tissues from primary colorectal carcinoma.
abstract: OBJECTIVE
  KL-6 mucin is MUC1 bearing sialylated carbohydrate epitopes recognized by KL-6 antibody. This study aimed to assess subcellular localization of KL-6 mucin in liver metastatic tissues from colorectal carcinoma and hepatocellular carcinoma tissues.
  
  
  METHODS
  Tissue samples were collected from 56 patients with liver metastasis of colorectal carcinoma and 92 patients with hepatocellular carcinoma who underwent a hepatectomy. Tissues were subjected to immunohistochemical analysis using KL-6 antibody.
  
  
  RESULTS
  All 56 cases with metastatic liver cancer showed positive staining for KL-6 mucin in cancer tissues but not in non-cancerous tissues. All staining was observed in the circumferential membrane and/or cytoplasm of the cancer cells. In contrast, no staining for KL-6 mucin was observed in either cancerous or non-cancerous tissues of the 92 patients with hepatocellular carcinoma.
  
  
  CONCLUSIONS
  KL-6 mucin may be an indicator for liver metastasis of colorectal carcinoma. Additionally, detection of KL-6 mucin may be helpful in distinguishing hepatocellular carcinoma from metastatic liver cancer.
authors.affiliation: Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
authors.forename: Keming
authors.initials: K
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Tang
authors.forename: Xianjun
authors.initials: X
authors.lastname: Qu
authors.forename: Qian
authors.initials: Q
authors.lastname: Guo
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Inagaki
authors.forename: Yasuji
authors.initials: Y
authors.lastname: Seyama
authors.forename: Hideki
authors.initials: H
authors.lastname: Abe
authors.forename: Ruoyan
authors.initials: R
authors.lastname: Gai
authors.forename: Norihiro
authors.initials: N
authors.lastname: Kokudo
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Sugawara
authors.forename: Munehiro
authors.initials: M
authors.lastname: Nakata
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Makuuchi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000951:Antigens, Neoplasm / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000378:metabolism; D006528:Carcinoma, Hepatocellular / Q000378:metabolism*; D015179:Colorectal Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000378:metabolism* / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D018396:Mucin-1 / Q000378:metabolism*
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D018396:Mucin-1