title: Structural interactomics: informatics approaches to aid the interpretation of genetic variation and the development of novel therapeutics.
abstract: Here we review the use of informatics in structural interactomics, with particular emphasis on understanding interfacial contacts in the development of novel therapeutics and the interpretation of genetic variation. We describe the availability and applicability of structural databases of protein interactions which facilitate this endeavour. We demonstrate the applicability of a structural interactomics approach to the study of the fibroblast growth factor (FGF)-stimulated mitogen-activated protein kinase (MAPK) pathway.
authors.affiliation: Department of Biochemistry, University of Cambridge, Old Addenbrookes site, 80 Tennis Court Road, Cambridge, UK.
authors.forename: Semin
authors.initials: S
authors.lastname: Lee
authors.forename: Alan
authors.initials: A
authors.lastname: Brown
authors.forename: William Ross
authors.initials: WR
authors.lastname: Pitt
authors.forename: Alicia Perez
authors.initials: AP
authors.lastname: Higueruelo
authors.forename: Sungsam
authors.initials: S
authors.lastname: Gong
authors.forename: George Richard
authors.initials: GR
authors.lastname: Bickerton
authors.forename: Adrian
authors.initials: A
authors.lastname: Schreyer
authors.forename: Duangrudee
authors.initials: D
authors.lastname: Tanramluk
authors.forename: Alison
authors.initials: A
authors.lastname: Baylay
authors.forename: Tom Leon
authors.initials: TL
authors.lastname: Blundell
mesh_terms: D019295:Computational Biology; D030541:Databases, Genetic; D055808:Drug Discovery; D014644:Genetic Variation; D006801:Humans; D025941:Protein Interaction Mapping; D015398:Signal Transduction