title: Vitamin D deficiency in young children with severe acute lower respiratory infection.
abstract: BACKGROUND
  Acute lower respiratory infection (ALRI) is one of the most common reasons for hospitalization and intensive care unit admission among children. Season related decreases in the immunomodulatory molecule, vitamin D, remain an unexplored factor that might contribute to the increased occurrence of ALRI in children.
  
  
  OBJECTIVE
  To investigate a possible association between vitamin D deficiency and respiratory infection by comparing serum 25 hydroxyvitamin D [25(OH)D] levels in a group of young children with ALRI to an age-matched group without respiratory infection.
  
  
  METHODS
  Participants with a diagnosis of bronchiolitis or pneumonia (n = 55 or 50, respectively), as well as control subjects without respiratory symptoms (n = 92), were recruited at the Royal University Hospital, Saskatoon, Saskatchewan, Canada from November 2007 to May 2008. 25(OH)D levels were measured in patient serum using a competitive enzyme linked immunoassay.
  
  
  RESULTS
  The mean vitamin D level for the entire ALRI group was not significantly different from the control group (81 +/- 40 vs. 83 +/- 30 nmol/L, respectively). The mean vitamin D level for the ALRI subjects admitted to the pediatric intensive care unit (49 +/- 24 nmol/L) was significantly lower than that observed for both control (83 +/- 30 nmol/L) and ALRI subjects admitted to the general pediatrics ward (87 +/- 39 nmol/L). Vitamin D deficiency remained statistically related to pediatric intensive care unit admission in the multivariate analysis.
  
  
  CONCLUSIONS
  No difference was observed in vitamin D levels between the entire ALRI group and control groups; however, significantly more children admitted to the pediatric intensive care unit with ALRI were vitamin D deficient. These findings suggest that the immunomodulatory properties of vitamin D might influence ALRI disease severity.
authors.affiliation: Department of Pediatrics, University of Saskatchewan, Saskatchewan, Canada.
authors.forename: J Dayre
authors.initials: JD
authors.lastname: McNally
authors.forename: Karen
authors.initials: K
authors.lastname: Leis
authors.forename: Loren A
authors.initials: LA
authors.lastname: Matheson
authors.forename: Chandima
authors.initials: C
authors.lastname: Karuananyake
authors.forename: Koravangattu
authors.initials: K
authors.lastname: Sankaran
authors.forename: Alan M
authors.initials: AM
authors.lastname: Rosenberg
mesh_terms: D000208:Acute Disease; D017677:Age Distribution; D001988:Bronchiolitis / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology; D016022:Case-Control Studies; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D016017:Odds Ratio; D011014:Pneumonia / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology; D011336:Probability; D012016:Reference Values; D012141:Respiratory Tract Infections / Q000453:epidemiology / Q000209:etiology; D018570:Risk Assessment; D012525:Saskatchewan; D012720:Severity of Illness Index; D017678:Sex Distribution; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000150:complications* / Q000175:diagnosis
chemical_list: D014807:Vitamin D; C104450:25-hydroxyvitamin D