[Pharmacodynamics of pain perception and polymorphism].
The regulation of biotransformation started with the mechanism of mass action between the concentrations of the substrates (product) and enzyme. Thereafter by understanding the protein tertiary structure, allosteric control mechanism appeared. The enzyme induction was brought into a new aspect by the development of genetic analysis. As a cellular economy, energy charge was found to be a new regulatory mechanism for glycolytic pathway. These regulatory systems showed a single concentration-effect curve of pharmacodynamics. By introduction of silent or non sense gene as in atypical cholinesterase, a given function was not operated. As most doctors are aware of the diverse sensitivity to opioids among patients, numbers and species of opioid receptors might be the cause. By extensive gene analysis, polymorphism may explain this phenotype. The polymorphism may also play an important role in the pain mechanism such as incidence of neuropathic pain and in the modulation of pain. You will find several curves of pharmocodynamics.
Kikuchi
Hirosato
H
Department of Anesthesiology, Saitama Medical University Hospital, Saitama 350-0495.
D000701:Analgesics, Opioid / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D006801:Humans; D010146:Pain / Q000235:genetics*; D010597:Pharmacogenetics; D011110:Polymorphism, Genetic; D011957:Receptors, Opioid / Q000235:genetics*
D000701:Analgesics, Opioid; D011957:Receptors, Opioid