title: Multiscale model of liver DCE-MRI towards a better understanding of tumor complexity.
abstract: The use of quantitative imaging for the characterization of hepatic tumors in magnetic resonance imaging (MRI) can improve the diagnosis and therefore the treatment of these life-threatening tumors. However, image parameters remain difficult to interpret because they result from a mixture of complex processes related to pathophysiology and to acquisition. These processes occur at variable spatial and temporal scales. We propose a multiscale model of liver dynamic contrast-enhanced (DCE) MRI in order to better understand the tumor complexity in images. Our design couples a model of the organ (tissue and vasculature) with a model of the image acquisition. At the macroscopic scale, vascular trees take a prominent place. Regarding the formation of MRI images, we propose a distributed model of parenchymal biodistribution of extracellular contrast agents. Model parameters can be adapted to simulate the tumor development. The sensitivity of the multiscale model of liver DCE-MRI was studied through observations of the influence of two physiological parameters involved in carcinogenesis (arterial flow and capillary permeability) on its outputs (MRI images at arterial and portal phases). Finally, images were simulated for a set of parameters corresponding to the five stages of hepatocarcinogenesis (from regenerative nodules to poorly differentiated HepatoCellular Carcinoma).
authors.affiliation: INSERM, U642, Rennes, F-35000, France. mmescam@mcw.edu
authors.forename: Muriel
authors.initials: M
authors.lastname: Mescam
authors.forename: Marek
authors.initials: M
authors.lastname: Kretowski
authors.forename: Johanne
authors.initials: J
authors.lastname: Bezy-Wendling
mesh_terms: D000465:Algorithms; D002199:Capillary Permeability; D006528:Carcinoma, Hepatocellular / Q000098:blood supply* / Q000473:pathology*; D003198:Computer Simulation; D003287:Contrast Media / Q000493:pharmacokinetics*; D006503:Hepatic Veins / Q000033:anatomy & histology / Q000473:pathology; D006571:Heterocyclic Compounds / Q000493:pharmacokinetics; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008102:Liver Circulation; D008113:Liver Neoplasms / Q000098:blood supply* / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008954:Models, Biological; D009389:Neovascularization, Pathologic / Q000378:metabolism / Q000473:pathology; D009942:Organometallic Compounds / Q000493:pharmacokinetics
chemical_list: D003287:Contrast Media; D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; C050823:gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate