Intracellular assembly and trafficking of MHC class I molecules.
The presentation of antigenic peptides by class I molecules of the major histocompatibility complex begins in the endoplasmic reticulum (ER) where the co-ordinated action of molecular chaperones, folding enzymes and class I-specific factors ensures that class I molecules are loaded with high-affinity peptide ligands that will survive prolonged display at the cell surface. Once assembled, class I molecules are released from the quality-control machinery of the ER for export to the plasma membrane where they undergo dynamic endocytic cycling and turnover. We review recent progress in our understanding of class I assembly, anterograde transport and endocytosis and highlight some of the events targeted by viruses as a means to evade detection by cytotoxic T cells and natural killer cells.
Donaldson
Julie G
JG
Laboratory of Cell Biology, National Heart, Lung and Blood Institute, NIH, Bethesda, MD 20892, USA.
Williams
David B
DB
D001692:Biological Transport; D015536:Down-Regulation; D004705:Endocytosis; D004721:Endoplasmic Reticulum / Q000378:metabolism; D015395:Histocompatibility Antigens Class I / Q000378:metabolism*; D006801:Humans; D054875:Ubiquitination
D015395:Histocompatibility Antigens Class I