title: Design and simulation of a poly(vinyl alcohol)-bacterial cellulose nanocomposite mechanical aortic heart valve prosthesis.
abstract: In this study, a polymeric aortic heart valve made of poly(vinyl alcohol) (PVA)-bacterial cellulose (BC) nanocomposite is simulated and designed using a hyperelastic non-linear anisotropic material model. A novel nanocomposite biomaterial combination of 15 wt % PVA and 0.5 wt % BC is developed in this study. The mechanical properties of the synthesized PVA-BC are similar to those of the porcine heart valve in both the principal directions. To design the geometry of the leaflets an advance surfacing technique is employed. A Galerkin-based non-linear finite element method is applied to analyse the mechanical behaviour of the leaflet in the closing and opening phases under physiological conditions. The model used in this study can be implemented in mechanical models for any soft tissues such as articular cartilage, tendon, and ligament.
authors.affiliation: Department of Biomedical Engineering, Faculty of Engineering, The University of Western Ontario, London, Ontario, Canada. hmohamm3@uwo.ca
authors.forename: H
authors.initials: H
authors.lastname: Mohammadi
authors.forename: D
authors.initials: D
authors.lastname: Boughner
authors.forename: L E
authors.initials: LE
authors.lastname: Millon
authors.forename: W K
authors.initials: WK
authors.lastname: Wan
mesh_terms: D001021:Aortic Valve; D001672:Biocompatible Materials / Q000737:chemistry*; D002482:Cellulose / Q000737:chemistry*; D017076:Computer-Aided Design; D019544:Equipment Failure Analysis; D041822:Gluconacetobacter xylinus / Q000737:chemistry*; D006350:Heart Valve Prosthesis; D006801:Humans; D008422:Materials Testing; D049329:Nanostructures / Q000737:chemistry*; D036103:Nanotechnology / Q000295:instrumentation; D011142:Polyvinyl Alcohol / Q000737:chemistry*; D011474:Prosthesis Design; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D001672:Biocompatible Materials; D011142:Polyvinyl Alcohol; D002482:Cellulose