Approaches for assessing risks to sensitive populations: lessons learned from evaluating risks in the pediatric population.
Assessing the risk profiles of potentially sensitive populations requires a "tool chest" of methodological approaches to adequately characterize and evaluate these populations. At present, there is an extensive body of literature on methodologies that apply to the evaluation of the pediatric population. The Health and Environmental Sciences Institute Subcommittee on Risk Assessment of Sensitive Populations evaluated key references in the area of pediatric risk to identify a spectrum of methodological approaches. These approaches are considered in this article for their potential to be extrapolated for the identification and assessment of other sensitive populations. Recommendations as to future research needs and/or alternate methodological considerations are also made.
Hines
Ronald N
RN
Medical College of Wisconsin, Department of Pediatrics, Children's Research Institute, Children's Hospital and Health Systems, Milwaukee, Wisconsin 53226-4801, USA.
Sargent
Dana
D
Autrup
Herman
H
Birnbaum
Linda S
LS
Brent
Robert L
RL
Doerrer
Nancy G
NG
Cohen Hubal
Elaine A
EA
Juberg
Daland R
DR
Laurent
Christian
C
Luebke
Robert
R
Olejniczak
Klaus
K
Portier
Christopher J
CJ
Slikker
William
W
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D015415:Biomarkers / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D004781:Environmental Exposure; D004784:Environmental Monitoring; D020022:Genetic Predisposition to Disease; D033161:Government Regulation; D006291:Health Policy; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008954:Models, Biological; D010599:Pharmacokinetics; D011634:Public Health / Q000331:legislation & jurisprudence / Q000379:methods*; D018570:Risk Assessment; D012307:Risk Factors; D018675:Toxicity Tests / Q000379:methods*
D015415:Biomarkers