Chemical constituents isolated from Paeonia lactiflora roots and their neuroprotective activity against oxidative stress in vitro.
The methanolic extract of Paeonia lactiflora roots significantly protected primary cultures of rat cortical cells exposed to oxidative stress induced by H(2)O(2). Seven monoterpenes, paeonilactone-B (1), paeonilactone-C (2), paeoniflorigenone (3), benzoylpaeoniflorin (4), paeoniflorin (5), oxypaeoniflorin (6) and albiflorin (7), were isolated by bioactivity-guided fractionation and further separation using chromatographic techniques. Among them, compounds 2 and 4 significantly protected primary cultures of rat cortical cells against H(2)O(2)-induced neurotoxicity.
Kim
Seung Hyun
SH
Institute for Life Science, ElcomScience Co Ltd, Seoul, Korea.
Lee
Mi Kyeong
MK
Lee
Ki Yong
KY
Sung
Sang Hyun
SH
Kim
Jinwoong
J
Kim
Young Choong
YC
D000818:Animals; D002470:Cell Survival; D002478:Cells, Cultured; D002525:Cerebellar Cortex / Q000737:chemistry* / Q000187:drug effects; D015394:Molecular Structure; D018696:Neuroprotective Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects*; D029596:Paeonia / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley
D018696:Neuroprotective Agents; D010936:Plant Extracts