Severity of Yin deficiency syndrome and autonomic nervous system function in cancer patients.
OBJECTIVE
To evaluate the distribution of symptoms related to Yin deficiency syndrome (YDS), and to analyze the relationship between the severity of YDS and the function of the autonomic nervous system (ANS) in cancer patients.


METHODS
Outpatient clinic in a teaching hospital in central Taiwan.


METHODS
Eighty (80) patients had been diagnosed with cancer by pathologic and clinical findings.


METHODS
The severity of YDS in each subject was evaluated by a questionnaire consisting of 12 items concerning symptoms and signs related to YDS, scored from 1 to 4 points.


METHODS
The total score for all 12 items represented the severity of YDS. ANS function in each subject was evaluated by measuring heart rate variability (HRV), including time-frequency analysis. We coded the collected questionnaire material and performed statistical analysis (description analysis, ANOVA, and Pearson's correlation coefficients) using SPSS v.12.0 software.


RESULTS
The highest total YDS score was 36 points and the lowest was 10 points. The 3 most common YDS signs were dry mouth (58.8%), sleeplessness with annoyance (56.3%), and flush over face in the afternoon (22.5%). The total YDS scores had a significantly positive correlation with heart rate (HR), but had significantly negative correlation with the standard deviation of the 5-minute mean R-R intervals (SDANN), total HRV power, power in the very low frequency band, and in the low frequency band.


CONCLUSIONS
The above results suggest that the severity of YDS in cancer patients was associated with increased HR and decreased ANS activity. There is a possibility that the disturbance of ANS function may contribute to the occurrence of YDS in cancer patients.
Lin
Shu-Chuan
SC
Department of Nursing, Show Chwan Memorial Hospital, Changhua, Taiwan, Republic of China.
Huang
Min-Lih
ML
Liu
Shwu-Jiuan
SJ
Huang
Ya-Fen
YF
Chiang
Shang-Chi
SC
Chen
Ming-Feng
MF
D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D001341:Autonomic Nervous System / Q000503:physiopathology*; D005260:Female; D005483:Flushing / Q000503:physiopathology; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications / Q000503:physiopathology*; D012720:Severity of Illness Index; D007319:Sleep Initiation and Maintenance Disorders / Q000503:physiopathology; D011795:Surveys and Questionnaires; D013577:Syndrome; D014987:Xerostomia / Q000503:physiopathology; D016710:Yin Deficiency / Q000150:complications / Q000503:physiopathology*