title: A prospective randomised trial of extended core prostate biopsy protocols utilizing 12 versus 15 cores.
abstract: OBJECTIVE
  To prospectively evaluate the diagnostic yield of 12 versus 15 core ultrasound-guided needle prostate biopsy protocol for detection of prostate cancer.
  
  
  METHODS
  244 patients were prospectively randomized to undergo 12 (group A), or 15 (group B) biopsies. The cancer detection rate was compared between these groups and within group B.
  
  
  RESULTS
  There were no differences in the age, PSA, prostate volume or Gleason score of diagnosed cancers between groups. 113 (46%) of all patients were found to have carcinoma. The number of cancers diagnosed in each group was: 63 (51.6%) in group A, and 50 (41.0%) in group B. In both groups, performing 12 biopsies increased the number of cancer cases identified by around 10% compared to 6. The frequency of cancer cases increased when 15 biopsies were performed, but not significantly (1.7%). The probability of finding a cancer after 12 biopsies was the same as after 15 biopsies (p = 0.125, McNemar's test).
  
  
  CONCLUSIONS
  There was no advantage in increasing the number of biopsy cores from 12 to 15 for the diagnosis of prostate cancer in men with an elevated PSA but normal digital rectal examination.
authors.affiliation: Department of Urology, West Suffolk Hospital, Bury St Edmunds, UK. rochester@doctors.org.uk
authors.forename: M A
authors.initials: MA
authors.lastname: Rochester
authors.forename: S
authors.initials: S
authors.lastname: Griffin
authors.forename: B
authors.initials: B
authors.lastname: Chappell
authors.forename: J
authors.initials: J
authors.lastname: McLoughlin
mesh_terms: D000368:Aged; D001707:Biopsy, Needle / Q000379:methods* / Q000706:statistics & numerical data; D002985:Clinical Protocols; D006801:Humans; D008297:Male; D011446:Prospective Studies; D011467:Prostate / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000473:pathology*