title: Regulation of the human SLC25A20 expression by peroxisome proliferator-activated receptor alpha in human hepatoblastoma cells.
abstract: Solute carrier family 25, member 20 (SLC25A20) is a key molecule that transfers acylcarnitine esters in exchange for free carnitine across the mitochondrial membrane in the mitochondrial beta-oxidation. The peroxisome proliferator-activated receptor alpha (PPARalpha) is a ligand-activated transcription factor that plays an important role in the regulation of beta-oxidation. We previously established tetracycline-regulated human cell line that can be induced to express PPARalpha and found that PPARalpha induces the SLC25A20 expression. In this study, we analyzed the promoter region of the human slc25a20 gene and showed that PPARalpha regulates the expression of human SLC25A20 via the peroxisome proliferator responsive element.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, Japan. nya@phs.osaka-u.ac.jp
authors.forename: Keisuke
authors.initials: K
authors.lastname: Tachibana
authors.forename: Kentaro
authors.initials: K
authors.lastname: Takeuchi
authors.forename: Hirohiko
authors.initials: H
authors.lastname: Inada
authors.forename: Daisuke
authors.initials: D
authors.lastname: Yamasaki
authors.forename: Kenji
authors.initials: K
authors.lastname: Ishimoto
authors.forename: Toshiya
authors.initials: T
authors.lastname: Tanaka
authors.forename: Takao
authors.initials: T
authors.lastname: Hamakubo
authors.forename: Juro
authors.initials: J
authors.lastname: Sakai
authors.forename: Tatsuhiko
authors.initials: T
authors.lastname: Kodama
authors.forename: Takefumi
authors.initials: T
authors.lastname: Doi
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D045744:Cell Line, Tumor; D006801:Humans; D026901:Membrane Transport Proteins / Q000235:genetics*; D008969:Molecular Sequence Data; D047493:PPAR alpha / Q000378:metabolism*; D011401:Promoter Regions, Genetic; D015533:Transcriptional Activation
chemical_list: D026901:Membrane Transport Proteins; D047493:PPAR alpha; C120109:SLC25A20 protein, human