Solid-phase peptide synthesis in water using microwave-assisted heating.
An approach using water as a solvent (coupling and deprotection) was developed for the solid-phase synthesis of peptides using the most common Boc-amino acid derivatives. Key aspects of this methodology are the use of a PEG-based resin, EDC-HONB as a coupling method, and microwave irradiation as an energy source.
Galanis
Athanassios S
AS
Department of Chemistry, Medicinal Chemistry, University of Gothenburg, SE-412 96 Goteborg, Sweden.
Albericio
Fernando
F
Grøtli
Morten
M
D000595:Amino Acid Sequence; D002851:Chromatography, High Pressure Liquid; D006358:Hot Temperature; D008872:Microwaves; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D013997:Time Factors; D014867:Water / Q000737:chemistry
D010455:Peptides; D014867:Water