title: Sellar collision tumor involving pituitary gonadotroph adenoma and chondroma: a potential clinical diagnosis.
abstract: We report on a 74-year-old male patient who presented with progressive neuroophthalmologic symptoms soon after the administration of a long-acting gonadotropin-releasing hormone agonist for treatment of a prostate cancer. Imaging revealed a destructively growing and extensively calcified sellar mass inconsistent with a pituitary adenoma. A transseptal transsphenoidal tumor mass reduction yielded a histological diagnosis of a collision tumor comprised of a gonadotroph adenoma intermingled with osteochondroma. We discuss a potential causal relationship between the administration of the long-acting gonadotropin-releasing hormone agonist and the sudden appearance of the previously unsuspected sellar lesion. Although the association of these two tumors is very likely coincidental, the possibility of causal relationship is addressed.
authors.affiliation: Department of Endocrinology, Diabetes and Clinical Nutrition, Bern University Hospital and University of Bern, Bern, Switzerland. Rahel.Sahli@insel.ch
authors.forename: Rahel
authors.initials: R
authors.lastname: Sahli
authors.forename: Emanuel
authors.initials: E
authors.lastname: Christ
authors.forename: Dominique
authors.initials: D
authors.lastname: Kuhlen
authors.forename: Olivier
authors.initials: O
authors.lastname: Giger
authors.forename: Istvan
authors.initials: I
authors.lastname: Vajtai
mesh_terms: D000236:Adenoma / Q000139:chemically induced / Q000175:diagnosis* / Q000473:pathology; D000368:Aged; D018931:Antineoplastic Agents, Hormonal / Q000009:adverse effects / Q000627:therapeutic use; D002812:Chondroma / Q000139:chemically induced / Q000175:diagnosis* / Q000473:pathology; D003940:Diagnostic Techniques, Endocrine; D052681:Gonadotrophs / Q000473:pathology*; D007987:Gonadotropin-Releasing Hormone / Q000009:adverse effects / Q000031:analogs & derivatives / Q000627:therapeutic use; D006801:Humans; D008297:Male; D018198:Mixed Tumor, Malignant / Q000139:chemically induced / Q000175:diagnosis* / Q000473:pathology; D016609:Neoplasms, Second Primary / Q000139:chemically induced / Q000175:diagnosis; D010911:Pituitary Neoplasms / Q000139:chemically induced / Q000175:diagnosis* / Q000473:pathology; D011471:Prostatic Neoplasms / Q000188:drug therapy; D012658:Sella Turcica / Q000473:pathology*; D013314:Stress, Mechanical
chemical_list: D018931:Antineoplastic Agents, Hormonal; D007987:Gonadotropin-Releasing Hormone