Combined vaccines - case study.
Application of the principles outlined in the WHO Guideline on Stability Evaluation of Vaccines is complicated by the nature of combination vaccines. Differences in degradation rates among the immunogens impose the restriction that shelf life is based on the most labile component. There is also a testing challenge with numerous components held at different stages of production.
Jivapisarnpong
Teeranart
T
Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand. teena@health.moph.go.th
D004341:Drug Evaluation / Q000379:methods* / Q000592:standards; D004355:Drug Stability; D017408:Guidelines as Topic; D006801:Humans; D017778:Vaccines, Combined / Q000493:pharmacokinetics* / Q000592:standards; D014944:World Health Organization
D017778:Vaccines, Combined