Nitric oxide-containing nanoparticles as an antimicrobial agent and enhancer of wound healing.
Nitric oxide (NO) is known to be involved in wound healing and to have antimicrobial actions. Developing a means of delivering a diatomic, gaseous free radical has been a technical challenge. Using a combination of techniques, Martinez and colleagues have developed an ingenious method of storing NO, and they demonstrate its efficacy in treating infected wounds.
Weller
Richard B
RB
Department of Dermatology, University of Edinburgh, Edinburgh, United Kingdom. r.weller@ed.ac.uk
D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D004195:Disease Models, Animal; D016503:Drug Delivery Systems; D051379:Mice; D053758:Nanoparticles / Q000627:therapeutic use*; D009569:Nitric Oxide / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use*; D013207:Staphylococcal Skin Infections / Q000188:drug therapy* / Q000378:metabolism; D013211:Staphylococcus aureus; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects*
D000890:Anti-Infective Agents; D009569:Nitric Oxide