title: The suggestion of a risk stratification system for febrile neutropenia in patients with hematologic disease.
abstract: We analyzed the prognostic factors from 259 cases of febrile neutropenia occurring in 137 patients with hematologic disease. Based on multivariate analysis, significant prognostic factors are recovery of neutropenia, respiratory infection, baseline serum albumin, baseline bicarbonate, baseline CRP, and CRP on the fifth day after antibiotic treatment. From these variables, we derived a predictive model for the prognosis of febrile neutropenia using baseline serum albumin, bicarbonate, and CRP, which could be easily checked before chemotherapy. Further studies in prospective setting are needed for the validation of this model.
authors.affiliation: Division of Hematology and Oncology, Department of Internal Medicine, College of Medicine, Korea University, Seoul, Republic of Korea.
authors.forename: Yong
authors.initials: Y
authors.lastname: Park
authors.forename: Dae Sik
authors.initials: DS
authors.lastname: Kim
authors.forename: Seh Jong
authors.initials: SJ
authors.lastname: Park
authors.forename: Hee Yun
authors.initials: HY
authors.lastname: Seo
authors.forename: Se Ryeon
authors.initials: SR
authors.lastname: Lee
authors.forename: Hwa Jung
authors.initials: HJ
authors.lastname: Sung
authors.forename: Kyong Hwa
authors.initials: KH
authors.lastname: Park
authors.forename: In Keun
authors.initials: IK
authors.lastname: Choi
authors.forename: Seok Jin
authors.initials: SJ
authors.lastname: Kim
authors.forename: Sang Cheul
authors.initials: SC
authors.lastname: Oh
authors.forename: Jae Hong
authors.initials: JH
authors.lastname: Seo
authors.forename: Chul Won
authors.initials: CW
authors.lastname: Choi
authors.forename: Byung Soo
authors.initials: BS
authors.lastname: Kim
authors.forename: Sang Won
authors.initials: SW
authors.lastname: Shin
authors.forename: Yeul Hong
authors.initials: YH
authors.lastname: Kim
authors.forename: Jun Suk
authors.initials: JS
authors.lastname: Kim
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000009:adverse effects*; D015415:Biomarkers / Q000032:analysis; D005260:Female; D005334:Fever; D019337:Hematologic Neoplasms / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D009503:Neutropenia / Q000139:chemically induced*; D011379:Prognosis; D012307:Risk Factors; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents; D015415:Biomarkers