Lipoxygenases - Structure and reaction mechanism.
Lipid oxidation is a common metabolic reaction in all biological systems, appearing in developmentally regulated processes and as response to abiotic and biotic stresses. Products derived from lipid oxidation processes are collectively named oxylipins. Initial lipid oxidation may either occur by chemical reactions or is derived from the action of enzymes. In plants this reaction is mainly catalyzed by lipoxygenase (LOXs) enzymes and during recent years analysis of different plant LOXs revealed insights into their enzyme mechanism. This review aims at giving an overview of concepts explaining the catalytic mechanism of LOXs as well as the different regio- and stereo-specificities of these enzymes.
Andreou
Alexandra
A
Georg-August-University, Albrecht-von-Haller-Institute for Plant Science, Department of Plant Biochemistry, D-37077 Göttingen, Germany.
Feussner
Ivo
I
D015227:Lipid Peroxidation / Q000502:physiology; D008084:Lipoxygenase / Q000737:chemistry* / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D008954:Models, Biological; D054883:Oxylipins / Q000737:chemistry / Q000378:metabolism; D010940:Plant Proteins / Q000737:chemistry* / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D013379:Substrate Specificity
D054883:Oxylipins; D010940:Plant Proteins; D008084:Lipoxygenase