The Helicobacter pylori Mfd protein is important for antibiotic resistance and DNA repair.
A Helicobacter pylori mutant defective in a putative mfd gene was constructed and characterized. The mfd gene is required for DNA repair and is involved in DNA recombination processes. The mfd mutant strain displayed a greatly increased susceptibility to antibiotics, indicating that this gene plays a significant role in the antibiotic resistance of H. pylori strain J99.
Lee
Gin Hyug
GH
Division of Gastroenterology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea.
Jeong
Jin-Yong
JY
Chung
Jun-Won
JW
Nam
Won-Hee
WH
Lee
Sun-Mi
SM
Pak
Jhang-Ho
JH
Choi
Kee Don
KD
Song
Ho June
HJ
Jung
Hwoon-Yong
HY
Kim
Jin-Ho
JH
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000502:physiology*; D015169:Colony Count, Microbial; D004260:DNA Repair; D024881:Drug Resistance, Bacterial; D017353:Gene Deletion; D016480:Helicobacter pylori / Q000187:drug effects* / Q000502:physiology*; D008826:Microbial Sensitivity Tests; D016685:Mitomycin / Q000494:pharmacology; D011995:Recombination, Genetic; D014157:Transcription Factors / Q000172:deficiency / Q000502:physiology*
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D014157:Transcription Factors; C072103:transcription repair coupling factor protein, Bacteria; D016685:Mitomycin