title: High temperature zincation of functionalized aromatics and heteroaromatics using TMPZnCl.LiCl and microwave irradiation.
abstract: A wide range of functional aryl and heteroaryl zinc reagents have been efficiently prepared via regio- and chemoselective zincation using TMPZnCl.LiCl and microwave irradiation. Sensitive functional groups like esters are compatible with the high temperatures of the reactions. The resulting zinc species undergo a number of subsequent reactions, providing highly functionalized aromatics and heteroaromatics in high yields.
authors.affiliation: Department Chemie, Ludwig-Maximilians-Universität München, Butenandstrasse 5-13, Haus F, 81377 München, Germany.
authors.forename: Marc
authors.initials: M
authors.lastname: Mosrin
authors.forename: Gabriel
authors.initials: G
authors.lastname: Monzon
authors.forename: Tomke
authors.initials: T
authors.lastname: Bresser
authors.forename: Paul
authors.initials: P
authors.lastname: Knochel
mesh_terms: D006358:Hot Temperature; D048031:JNK Mitogen-Activated Protein Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism; D018021:Lithium Chloride / Q000737:chemistry*; D008872:Microwaves; D047428:Protein Kinase Inhibitors / Q000737:chemistry; D015032:Zinc / Q000737:chemistry*
chemical_list: D047428:Protein Kinase Inhibitors; D048031:JNK Mitogen-Activated Protein Kinases; D018021:Lithium Chloride; D015032:Zinc