The Sonoma water evaluation trial: a randomized drinking water intervention trial to reduce gastrointestinal illness in older adults.
OBJECTIVE
We estimated the relative rate of highly credible gastrointestinal illness (HCGI) per year associated with active versus sham household water filtration devices among older adults in a community receiving tap water meeting current US standards.


METHODS
We conducted a randomized, triple-blinded, crossover trial in 714 households (988 individuals), which used active and sham water filtration devices for 6 months each. We estimated the annual incidence rate ratio of HCGI episodes and the longitudinal prevalence ratio of HCGI days at population and individual levels with a generalized estimating equation (GEE) and generalized linear mixed models (GLMMs), respectively, adjusted for covariates associated with outcome.


RESULTS
The incidence rate ratios (active versus sham) were 0.88 (95% confidence interval [CI] = 0.77, 1.00) and 0.85 (95% CI = 0.76, 0.94) HCGI episodes per year estimated by GEE and GLMM models, respectively. The corresponding longitudinal prevalence ratios were 0.88 (95% CI = 0.74, 1.05) and 0.84 (95% CI = 0.78, 0.90) HCGI days per person per year.


CONCLUSIONS
We observed reductions in population- and individual-level measures of HCGI associated with use of the active filtration device. These findings suggest the need for further research on the impact of drinking water on the health of sensitive subpopulations.
Colford
John M
JM
School of Public Health, University of California, 50 University Hall, MC 7360, Berkeley, CA 94720-7360, USA. jcolford@berkeley.edu
Hilton
Joan F
JF
Wright
Catherine C
CC
Arnold
Benjamin F
BF
Saha
Sona
S
Wade
Timothy J
TJ
Scott
James
J
Eisenberg
Joseph N S
JN
D000368:Aged; D000369:Aged, 80 and over; D002140:California / Q000453:epidemiology; D018592:Cross-Over Studies; D005260:Female; D005374:Filtration; D005767:Gastrointestinal Diseases / Q000453:epidemiology / Q000517:prevention & control*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D018508:Water Purification / Q000379:methods*; D014881:Water Supply