XRCC1 codon 280 and ERCC2 codon 751 polymorphisms and risk of esophageal squamous cell carcinoma in a Chinese population.
Numerous candidate genes have been proposed as susceptibility factors for the development of esophageal squamous cell carcinoma (ESCC). XRCC1 (X-ray cross-complementing group 1) codon 280 and ERCC2 (excision repair cross complementing group 2) codon 751 polymorphisms were studied in ESCC in a Chinese population. The aim of this study is to investigate the potential association between single-nucleotide polymorphisms (SNP) of XRCC1 codon 280 His and ERCC2 codon 751 Gln polymorphisms and ESCC. Peripheral blood samples of 200 cases and 200 age-and-gender matching controls were collected from a Chinese population and the two polymorphisms were studied by means of polymerase chain reaction (PCR) restriction fragment length polymorphism techniques. Our results showed that XRCC1 codon 280 His allele had no significant difference between ESCC patients and normal controls (P > 0.05), while ERCC2 codon 751Gln allele was associated with a borderline decrease of ESCC (odds ratio [OR] = 0.628, 95% confidence interval [CI]: 0.400-0.986).
Zhai
Xian-Dun
XD
Institute of Forensic Medicine, Hennan University of Science and Technoogy, Luoyang 471003, Henan, China. professormo@yahoo.cn
Mo
Yao-Nan
YN
Xue
Xiao-Qi
XQ
Zhao
Gui-Sen
GS
Gao
Lin-Bo
LB
Ai
Hong-Wei
HW
Ye
Yi
Y
D000483:Alleles; D044466:Asian People / Q000208:ethnology; D002294:Carcinoma, Squamous Cell / Q000208:ethnology / Q000235:genetics*; D016022:Case-Control Studies; D003062:Codon / Q000235:genetics; D004260:DNA Repair / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics*; D004938:Esophageal Neoplasms / Q000208:ethnology / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D000076105:X-ray Repair Cross Complementing Protein 1; D051759:Xeroderma Pigmentosum Group D Protein / Q000235:genetics*
D003062:Codon; D004268:DNA-Binding Proteins; D000076105:X-ray Repair Cross Complementing Protein 1; C000619371:XRCC1 protein, human; D051759:Xeroderma Pigmentosum Group D Protein; C497292:ERCC2 protein, human