title: Acrylamide formed at physiological temperature as a result of asparagine oxidation.
abstract: Acrylamide is a probable human carcinogen that is neurotoxic to both humans and animals. It is known to be formed during cooking of foods at temperatures higher than 120 degrees C. The present study demonstrates that acrylamide can also be formed at physiological conditions (37 degrees C, pH 7.4) when asparagine is incubated in the presence of hydrogen peroxide (H(2)O(2)). The formation of acrylamide under these conditions is dependent on the incubation time and the concentration of H(2)O(2). Thus, the results raise the question of the possible endogenous formation of acrylamide in pathological conditions that are associated with long-term oxidative stress. Further studies are therefore warranted to clarify the possible endogenous formation of acrylamide and its significance in chronic conditions that are known to be associated with oxidative stress.
authors.affiliation: Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079, USA. edunatar@hotmail.com
authors.forename: Eden
authors.initials: E
authors.lastname: Tareke
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Heinze
authors.forename: Gonçalo
authors.initials: G
authors.lastname: Gamboa da Costa
authors.forename: Syed
authors.initials: S
authors.lastname: Ali
mesh_terms: D020106:Acrylamide / Q000737:chemistry*; D001216:Asparagine / Q000737:chemistry*; D006861:Hydrogen Peroxide / Q000737:chemistry; D010084:Oxidation-Reduction; D013696:Temperature
chemical_list: D020106:Acrylamide; D001216:Asparagine; D006861:Hydrogen Peroxide