title: Elective caesarean operation in the bitch using aglepristone before the pre-partum decline in peripheral progesterone concentration.
abstract: The aim of this study was to investigate caesarean operation (CO) undertaken before the pre-partum decrease of progesterone but following administration of a progesterone receptor antagonist and to evaluate the innocuity of this procedure for the dam and pups. Thirty seven bitches of 15 different breeds, received an injection of 15 mg/kg aglepristone 59 or 60 days after the estimated day of ovulation, determined by progesterone quantitative assays, and caesarean section (CS) was performed between 20 and 24 h after administration. Progesterone remained above 6 nmol/l at the time of CS (mean = 15.75, SD = 3.84). No post-operative clinical complications were reported in any of the bitches. All bitches were able to nurse and feed their puppies in the first 24 h following surgery. No pups showed any signs of prematurity and 5 out of 188 pups (2.6) died in the first 2 weeks after delivery. This small study demonstrates that a CS may be safely and successfully performed an average of 2 days before the expected date of parturition following the administration of aglepristone, without any harmful consequence for the dam and her neonates.
authors.affiliation: Ecole Nationale Vétérinaire d'Alfort, Paris, France. vetlevy@yahoo.fr
authors.forename: X
authors.initials: X
authors.lastname: Levy
authors.forename: E
authors.initials: E
authors.lastname: Fontaine
authors.forename: V
authors.initials: V
authors.lastname: Segalini
authors.forename: A
authors.initials: A
authors.lastname: Fontbonne
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D002585:Cesarean Section / Q000662:veterinary*; D004285:Dogs; D004334:Drug Administration Schedule; D004963:Estrenes / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D011247:Pregnancy; D011374:Progesterone / Q000097:blood* / Q000378:metabolism; D011980:Receptors, Progesterone / Q000037:antagonists & inhibitors*
chemical_list: D004963:Estrenes; D011980:Receptors, Progesterone; C419063:aglepristone; D011374:Progesterone