Polymorphism of the CYP1A1*2A gene and susceptibility to lung cancer in a Brazilian population.
OBJECTIVE
To estimate and compare the frequency of CYP1A1*2A gene polymorphisms in a Brazilian population and determine the possible contribution of these genetic variations to lung cancer risk.


METHODS
The study population included 200 patients with lung cancer, and the control group consisted of 264 blood donors. Genomic DNA was obtained from peripheral blood samples. The PCR-RFLP method was used for analysis of the CYP1A1*2A gene.


RESULTS
There was no statistically significant difference between the lung cancer patients and the controls in terms of the distribution of CYP1A1*2A polymorphisms (p = 0.49). A multivariate logistic regression model analysis by ethnic group revealed that, within the lung cancer group, the CYP1A1*2A genotype CC plus TC was more common among the African-Brazilian patients than among the White patients (adjusted OR = 3.19; 95% CI: 1.53-6.65).


CONCLUSIONS
The CYP1A1*2A gene cannot be linked with lung cancer risk in Brazilian patients at this time. Larger epidemiologic studies are needed in order to establish whether the CC plus TC polymorphism increases the risk of lung cancer in African-Brazilians.
Honma
Helen Naemi
HN
Laboratory of Pulmonology/Oncology, School of Medical Sciences, University at Campinas, Campinas, Brazil. helennaemi@ig.com.br
De Capitani
Eduardo Mello
EM
Barbeiro
Aristóteles de Souza
Ade S
Costa
Daniel Botelho
DB
Morcillo
André
A
Zambon
Lair
L
D044383:Black People / Q000235:genetics; D001938:Brazil / Q000208:ethnology; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics*; D004198:Disease Susceptibility; D004812:Epidemiologic Methods; D005260:Female; D005838:Genotype; D006801:Humans; D008175:Lung Neoplasms / Q000208:ethnology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D044465:White People / Q000235:genetics
D019363:Cytochrome P-450 CYP1A1