A new ion channel blooms at the synapse.
A new study by Yao et al. in the current issue of Cell proposes that a novel vesicular protein, dubbed Flower, regulates endocytosis by controlling presynaptic Ca(2+) levels. This finding is intriguing not only for its implications for vesicle cycling, but also for the multitude of Ca(2+)-dependent processes at play in presynaptic nerve terminals.
Kuo
Sidney P
SP
Oregon Hearing Research Center and Vollum Institute, Oregon Health and Science University, Portland, OR 97239, USA. kuos@ohsu.edu
Trussell
Laurence O
LO
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000235:genetics / Q000378:metabolism*; D002462:Cell Membrane / Q000502:physiology; D004330:Drosophila; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism*; D004705:Endocytosis / Q000502:physiology*; D009469:Neuromuscular Junction / Q000502:physiology; D017729:Presynaptic Terminals / Q000502:physiology*; D017385:Sequence Homology; D013572:Synaptic Vesicles / Q000502:physiology*
D015220:Calcium Channels; D029721:Drosophila Proteins; C543900:fwe protein, Drosophila; D002118:Calcium