Crack cocaine use increases the incidence of AIDS-defining events in French Guiana.
We conducted a retrospective cohort study to determine the influence of crack cocaine use on the outcomes of HIV infection. The use of crack cocaine was associated with an increased incidence of AIDS: 27.8 per 100 person-years versus 6.6 per 100 person-years for nonusers, adjusted hazard ratio = 3.8 (1.9-7.5), P < 0.001. More specifically, crack users had a greater incidence of disseminated histoplasmosis, pneumocystosis, pulmonary tuberculosis, bacterial pneumonia, oesophageal candidiasis, cerebral toxoplasmosis, salmonellosis, and genital herpes. The care of HIV-infected crack users is particularly challenging and requires additional efforts to reduce the high morbidity of these patients.
Nacher
Mathieu
M
Centre d'Investigation Clinique Epidémiologie Clinique Antilles Guyane (CIC EC CIE802), French Guiana.
Adenis
Antoine
A
Hanf
Matthieu
M
Adriouch
Leila
L
Vantilcke
Vincent
V
El Guedj
Myriam
M
Vaz
Tania
T
Dufour
Julie
J
Couppié
Pierre
P
D023241:Antiretroviral Therapy, Highly Active; D019970:Cocaine-Related Disorders / Q000150:complications / Q000401:mortality*; D016578:Crack Cocaine / Q000009:adverse effects*; D018450:Disease Progression; D005260:Female; D005616:French Guiana / Q000453:epidemiology; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy / Q000401:mortality*; D006801:Humans; D015994:Incidence; D008297:Male; D012189:Retrospective Studies; D019562:Viral Load
D016578:Crack Cocaine