The alternating power stroke of a 6-cylinder AAA protease chaperone engine.
In this issue of Molecular Cell, Augustin et al. (2009) describe the regulatory coupling of adjacent ATP subunits in the mitochondrial AAA protease ring along with the responsible molecular determinants and uncover its importance for membrane dislocation of substrates.
Kress
Wolfgang
W
ETH Zurich, Institute of Molecular Biology and Biophysics, Switzerland.
Weber-Ban
Eilika
E
D049069:ATP-Dependent Proteases; D000074183:ATPases Associated with Diverse Cellular Activities; D000251:Adenosine Triphosphatases / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism*; D000494:Allosteric Regulation; D020816:Amino Acid Motifs; D001665:Binding Sites; D020134:Catalytic Domain; D017124:Conserved Sequence; D004734:Energy Metabolism; D005656:Fungal Proteins / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D006868:Hydrolysis; D007700:Kinetics; D008666:Metalloendopeptidases / Q000737:chemistry / Q000378:metabolism*; D051336:Mitochondrial Membranes / Q000201:enzymology*; D008958:Models, Molecular; D018832:Molecular Chaperones / Q000737:chemistry / Q000378:metabolism*; D021122:Protein Subunits; D015398:Signal Transduction; D013329:Structure-Activity Relationship; D013379:Substrate Specificity; D015003:Yeasts / Q000201:enzymology* / Q000254:growth & development
D005656:Fungal Proteins; D018832:Molecular Chaperones; D021122:Protein Subunits; D000255:Adenosine Triphosphate; D049069:ATP-Dependent Proteases; C120699:AFG3L2 protein, human; D008666:Metalloendopeptidases; C112889:SPG7 protein, human; C114583:m-AAA proteases; D000251:Adenosine Triphosphatases; D000074183:ATPases Associated with Diverse Cellular Activities