title: Proteolysis in the SOS response and metal homeostasis in Escherichia coli.
abstract: Proteolysis is used by all forms of life for shaping the proteome in response to adverse environmental conditions in order to ensure optimal survival. Here we will address the role of proteolysis in helping cells respond to environmental stress, with a focus on the impact of proteolysis under DNA-damaging conditions and in maintenance of cellular homeostasis in response to metal exposure in bacteria.
authors.affiliation: Howard Hughes Medical Institute, Massachusetts Institute of Technology, Building 68-523, 77 Massachusetts Ave, Cambridge, MA 02139, USA. mpruteanu@ahealth.ie
authors.forename: Mihaela
authors.initials: M
authors.lastname: Pruteanu
authors.forename: Tania A
authors.initials: TA
authors.lastname: Baker
mesh_terms: D000251:Adenosine Triphosphatases / Q000235:genetics / Q000378:metabolism; D001426:Bacterial Proteins / Q000378:metabolism; D055162:Biocatalysis; D004249:DNA Damage; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D004259:DNA-Directed DNA Polymerase / Q000235:genetics / Q000378:metabolism; D004926:Escherichia coli / Q000201:enzymology* / Q000235:genetics; D029968:Escherichia coli Proteins / Q000235:genetics / Q000378:metabolism*; D006706:Homeostasis / Q000235:genetics; D008670:Metals / Q000378:metabolism* / Q000633:toxicity; D013014:SOS Response, Genetics / Q000235:genetics; D012697:Serine Endopeptidases / Q000378:metabolism; D013312:Stress, Physiological; D014157:Transcription Factors / Q000378:metabolism; D000099160:LexA Repressor Protein
chemical_list: D000251:Adenosine Triphosphatases; D001426:Bacterial Proteins; D004268:DNA-Binding Proteins; D004259:DNA-Directed DNA Polymerase; D029968:Escherichia coli Proteins; D008670:Metals; D012697:Serine Endopeptidases; D014157:Transcription Factors; D000099160:LexA Repressor Protein; C492246:ZntR protein, E coli; C120926:DNA polymerase V, E coli; C068631:UvrA protein, E coli