title: CMR findings in patients with hypertrophic cardiomyopathy and atrial fibrillation.
abstract: OBJECTIVE
  We sought to evaluate the relation between atrial fibrillation (AF) and the extent of myocardial scarring together with left ventricular (LV) and atrial parameters assessed by late gadolinium-enhancement (LGE) cardiovascular magnetic resonance (CMR) in patients with hypertrophic cardiomyopathy (HCM).
  
  
  BACKGROUND
  AF is the most common arrhythmia in HCM. Myocardial scarring is also identified frequently in HCM. However, the impact of myocardial scarring assessed by LGE CMR on the presence of AF has not been evaluated yet.
  
  
  METHODS
  87 HCM patients underwent LGE CMR, echocardiography and regular ECG recordings. LV function, volumes, myocardial thickness, left atrial (LA) volume and the extent of LGE, were assessed using CMR and correlated to AF. Additionally, the presence of diastolic dysfunction and mitral regurgitation were obtained by echocardiography and also correlated to AF.
  
  
  RESULTS
  Episodes of AF were documented in 37 patients (42%). Indexed LV volumes and mass were comparable between HCM patients with and without AF. However, indexed LA volume was significantly higher in HCM patients with AF than in HCM patients without AF (68 +/- 24 ml.m-2 versus 46 +/- 18 ml.m-2, p = 0.0002, respectively). The mean extent of LGE was higher in HCM patients with AF than those without AF (12.4 +/- 14.5% versus 6.0 +/- 8.6%, p = 0.02). When adjusting for age, gender and LV mass, LGE and indexed LA volume significantly correlated to AF (r = 0.34, p = 0.02 and r = 0.42, p < 0.001 respectively). By echocardiographic examination, LV diastolic dysfunction was evident in 35 (40%) patients. Mitral regurgitation greater than II was observed in 12 patients (14%). Multivariate analysis demonstrated that LA volume and presence of diastolic dysfunction were the only independent determinant of AF in HCM patients (p = 0.006, p = 0.01 respectively). Receiver operating characteristic curve analysis indicated good predictive performance of LA volume and LGE (AUC = 0.74 and 0.64 respectively) with respect to AF.
  
  
  CONCLUSIONS
  HCM patients with AF display significantly more LGE than HCM patients without AF. However, the extent of LGE is inferior to the LA size for predicting AF prevalence. LA dilation is the strongest determinant of AF in HCM patients, and is related to the extent of LGE in the LV, irrespective of LV mass.
authors.affiliation: 1st Department of Medicine-Cardiology, University Hospital of Mannheim, Mannheim, Germany. theano.papavassiliu@umm.de
authors.forename: Theano
authors.initials: T
authors.lastname: Papavassiliu
authors.forename: Tjeerd
authors.initials: T
authors.lastname: Germans
authors.forename: Stephan
authors.initials: S
authors.lastname: Flüchter
authors.forename: Christina
authors.initials: C
authors.lastname: Doesch
authors.forename: Anton
authors.initials: A
authors.lastname: Suriyakamar
authors.forename: Dariusch
authors.initials: D
authors.lastname: Haghi
authors.forename: Tim
authors.initials: T
authors.lastname: Süselbeck
authors.forename: Christian
authors.initials: C
authors.lastname: Wolpert
authors.forename: Dietmar
authors.initials: D
authors.lastname: Dinter
authors.forename: Stefan O
authors.initials: SO
authors.lastname: Schoenberg
authors.forename: Albert C
authors.initials: AC
authors.lastname: van Rossum
authors.forename: Martin
authors.initials: M
authors.lastname: Borggrefe
mesh_terms: D000328:Adult; D000368:Aged; D001281:Atrial Fibrillation / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology; D002312:Cardiomyopathy, Hypertrophic / Q000150:complications / Q000473:pathology* / Q000503:physiopathology; D003287:Contrast Media; D018618:Echocardiography, Doppler, Color; D015716:Electrocardiography, Ambulatory; D005260:Female; D019786:Gadolinium DTPA; D006325:Heart Atria / Q000473:pathology; D006352:Heart Ventricles / Q000473:pathology; D006801:Humans; D019028:Magnetic Resonance Imaging, Cine; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000209:etiology / Q000473:pathology; D009206:Myocardium / Q000473:pathology; D011237:Predictive Value of Tests; D012372:ROC Curve; D012307:Risk Factors; D018487:Ventricular Dysfunction, Left / Q000209:etiology / Q000473:pathology
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA