Identification of antiadipogenic constituents of the rhizomes of Anemarrhena asphodeloides.
Three new phenolic compounds, (E)-4'-demethyl-6-methyleucomin (1), anemarcoumarin A (2), and anemarchalconyn (3), were isolated from an ethyl acetate extract of the rhizomes of Anemarrhena asphodeloides, together with seven known compounds (4-10). The structures of the new compounds (1-3) were determined on the basis of spectroscopic data interpretation. Compound 3 exhibited a potent inhibitory effect against the differentiation of preadipocyte 3T3-L1 cells with an IC50 value of 5.3 microM.
Youn
Ui Joung
UJ
The Center for Cell Signaling & Drug Discovery Research, College of Pharmacy, Ewha Womans University, Seoul 120-750, Korea.
Lee
Ye Seul
YS
Jeong
Hana
H
Lee
Jun
J
Nam
Joo-Won
JW
Lee
Yoo Jin
YJ
Hwang
Eun Sook
ES
Lee
Je-Hyun
JH
Lee
Dongho
D
Kang
Sam Sik
SS
Seo
Eun-Kyoung
EK
D041721:3T3-L1 Cells / Q000187:drug effects; D050156:Adipogenesis / Q000187:drug effects*; D031403:Anemarrhena / Q000737:chemistry*; D000818:Animals; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D007723:Korea; D051379:Mice; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D027343:Rhizome / Q000737:chemistry
C545133:(E)-4'-demethyl-6-methyleucomin; D003374:Coumarins; D010636:Phenols; C545134:anemarchalconyn; C545135:anemarcoumarin A