Synthesis and dopaminergic activity of some E-3-(piperidin-1-yl)-1-(4-substituted phenyl)prop-2-en-1-one derivatives.
A convenient route for the synthesis of some 2-propen-1-one derivatives with E isomeric configuration is described. The activity of the synthesized compounds was evaluated through behavioral studies of apomorphine-induced licking in animal models. It was demonstrated that most of the synthesized compounds showed moderate activity in inhibition of lickings, among which 6a, was the most active compound at 30 mg/kg.
Sakhteman
Amirhossein
A
Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran 14174, Iran.
Foroumadi
Alireza
A
Sharifzadeh
Mohammad
M
Amanlou
Masoud
M
Rayatnia
Farhoud
F
Shafiee
Abbas
A
D000475:Alkenes / Q000138:chemical synthesis / Q000494:pharmacology; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology / Q000627:therapeutic use; D001522:Behavior, Animal / Q000187:drug effects; D018491:Dopamine Agonists / Q000138:chemical synthesis* / Q000494:pharmacology; D007659:Ketones / Q000138:chemical synthesis* / Q000494:pharmacology; D010880:Piperidines / Q000138:chemical synthesis* / Q000494:pharmacology
D000475:Alkenes; D018491:Dopamine Agonists; D007659:Ketones; D010880:Piperidines; C013658:propylene; D001058:Apomorphine