Host tolerance versus resistance and microbial virulence in the host-pathogen equation.
To deal with an infection, the organism resorts to nonmutually exclusive strategies: resistance, that is, neutralization or destruction of the pathogen; or tolerance, the ability to withstand damages inflicted by the pathogen or by host defense. In this issue of Cell Host & Microbe, Shinzawa et al. (2009) identify p38-mediated phagocytic encapsulation as a potential tolerance mechanism.
Ferrandon
Dominique
D
UPR 9022 du CNRS, Université de Strasbourg, Institut de Biologie Moléculaire et Cellulaire, Strasbourg Cedex, France. d.ferrandon@ibmc.u-strasbg.fr
D000818:Animals; D004330:Drosophila / Q000276:immunology* / Q000382:microbiology*; D054884:Host-Pathogen Interactions; D007108:Immune Tolerance; D012486:Salmonella typhimurium / Q000472:pathogenicity* / Q000502:physiology; D014774:Virulence