title: Molecular analysis of carbohydrate N-acetylgalactosamine 4-O sulfotransferase 8 (CHST8) as a candidate gene for bovine spongiform encephalopathy susceptibility.
abstract: Endogenous prion proteins (PrP) play the central role in the pathogenesis of transmissible spongiform encephalopathies. The carbohydrate N-acetylgalactosamine 4-O sulfotransferase 8 (CHST8) promotes the conversion of the cellular PrP(C) into the pathogenic PrP(d). Six sequence variants within the CHST8 gene were identified by comparative sequencing and genotyped for a sample of 623 animals comprising bovine spongiform encephalopathy (BSE)-affected and healthy control cows representing German Fleckvieh (German Simmental), German Holstein (Holstein-Friesian) and Brown Swiss. Significant differences in the allele, genotype and haplotype frequencies between BSE-affected and healthy cows indicate an association of sequence variant g.37254017G>T with the development of the disease in Brown Swiss cattle.
authors.affiliation: Institute of Veterinary Medicine, Georg-August University, Goettingen, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Morina
authors.forename: C
authors.initials: C
authors.lastname: Knorr
authors.forename: B
authors.initials: B
authors.lastname: Haase
authors.forename: T
authors.initials: T
authors.lastname: Leeb
authors.forename: T
authors.initials: T
authors.lastname: Seuberlich
authors.forename: A
authors.initials: A
authors.lastname: Zurbriggen
authors.forename: G
authors.initials: G
authors.lastname: Brem
authors.forename: E
authors.initials: E
authors.lastname: Schütz
authors.forename: B
authors.initials: B
authors.lastname: Brenig
mesh_terms: D000818:Animals; D002417:Cattle / Q000235:genetics*; D016643:Encephalopathy, Bovine Spongiform / Q000235:genetics* / Q000378:metabolism; D020022:Genetic Predisposition to Disease; D018621:PrPC Proteins / Q000378:metabolism; D015238:Sulfotransferases / Q000235:genetics* / Q000378:metabolism; D000097811:Carbohydrate Sulfotransferases
chemical_list: D018621:PrPC Proteins; D015238:Sulfotransferases; D000097811:Carbohydrate Sulfotransferases