title: Comparative analysis of the Epstein-Barr virus encoded nuclear proteins of EBNA-3 family.
abstract: It is known that the EBNA-3 family proteins (EBNA-3, -4 and -6, alternative nomenclature EBNA-3A, B and C correspondingly) show a limited sequence similarity. We have analyzed EBNA-3 proteins both at the primary sequence and secondary structure levels. EBNA-3 and EBNA-4 were structurally more similar compared to other combinations with EBNA-6. We found "Stonin Homology Domain" profile in EBNA-4 and "Proline Rich Domain" in all EBNA-3 family of proteins. We have also found positive and negative charge clusters in all three proteins and mixed charge clusters in EBNA-3. Charged clusters are believed to play an important role in interactions with DNA or signaling proteins. Additionally, unique primary sequence repeats were found in all three proteins.
authors.affiliation: Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, S-17177 Stockholm, Sweden.
authors.forename: Surya Pavan
authors.initials: SP
authors.lastname: Yenamandra
authors.forename: Ramakrishna
authors.initials: R
authors.lastname: Sompallae
authors.forename: George
authors.initials: G
authors.lastname: Klein
authors.forename: Elena
authors.initials: E
authors.lastname: Kashuba
mesh_terms: D000595:Amino Acid Sequence; D004854:Herpesvirus 4, Human / Q000737:chemistry*; D008969:Molecular Sequence Data; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D017386:Sequence Homology, Amino Acid; D014764:Viral Proteins / Q000737:chemistry*
chemical_list: D014764:Viral Proteins