Highly enantioselective alkylation reaction of enamides by Brønsted-acid catalysis.
The H8-BINOL-derived, phosphoric acid catalyzed, highly enatioselective alkylation reaction of enamides with indolyl alcohols has been described. A phosphoric acid derived from H8-BINOL enabled an asymmetric alpha-alkylation of enamides with indolyl alcohols to give beta-aryl 3-(3-indolyl)propanones in high yields (up to 96%) and with excellent enantioselectivity (up to 96% ee).
Guo
Qi-Xiang
QX
School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China. qxguo@swu.edu.cn
Peng
Yun-Gui
YG
Zhang
Jin-Wei
JW
Song
Liu
L
Feng
Zhang
Z
Gong
Liu-Zhu
LZ