Adverse effects of medications commonly used in the treatment of migraine.
The classes of medications for migraine treatment are numerous and include ergots, triptans, NSAIDs, antidepressants, anti-epilepsy drugs, antihypertensives and natural supplements. Physicians need to be aware not only of medication efficacy but also of tolerability and safety. Side effects of these drugs can sometimes be beneficial, as migraineurs frequently have comorbid conditions. For example, those with insomnia can benefit from use of a tricyclic antidepressant that is effective in preventing migraine. However, these same coexistent conditions can be worsened by migraine medication or be contraindicated and multiple medications prescribed for several conditions can result in drug-drug interactions. This article reviews adverse events associated with migraine and medications, and their implications in clinical treatment.
Whyte
Chad A
CA
Center for Headache and Pain, Cleveland Clinic Foundation, 9500 Euclid Ave T33, Cleveland OH 44195, USA. whytec@ccf.org
Tepper
Stewart J
SJ
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000627:therapeutic use; D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D000928:Antidepressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008881:Migraine Disorders / Q000150:complications* / Q000188:drug therapy*; D014363:Tryptamines / Q000009:adverse effects* / Q000627:therapeutic use
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000927:Anticonvulsants; D000928:Antidepressive Agents; D000959:Antihypertensive Agents; D014363:Tryptamines