Mania and attention-deficit/hyperactivity disorder: common symptomatology, common pathophysiology and common treatment?
OBJECTIVE
Attention-deficit/hyperactivity disorder (ADHD) and mania show broad symptom overlap, and high comorbidity exists between ADHD and bipolar disorder. This raises the question concerning common neurobiological pathomechanisms and concerning common treatments.


RESULTS
On genetic, biochemical, electrophysiological, brain morphological and neuropsychological levels, the commonalities of ADHD and mania and the commonalities between ADHD and bipolar disorder (independent of manic state) are outlined. An intriguing finding is that both ADHD and mania are characterized by an unstable wakefulness regulation assessed by EEG measures of vigilance, by ratings of sleepiness and by deficits in sustained attention tasks. In both mania and ADHD, this unstable wakefulness regulation is supposed to be a central pathogenetic factor leading to attention deficits and inducing the hyperactive, impulsive and sensation-seeking behavior as an autoregulatory attempt to stabilize wakefulness by increasing external stimulation. Evidence is accumulating to suggest that psychostimulants do not have a high risk of triggering or aggravating mania, but might even be a treatment option in acute mania.


CONCLUSIONS
ADHD and mania share many symptoms and several pathogenetic aspects. The common belief that stimulants are contraindicated in mania has been challenged, and controlled trials to study the possible antimanic effects of vigilance-stabilizing drugs such as stimulants are justified and necessary.
Hegerl
Ulrich
U
Department of Psychiatry, University of Leipzig, Semmelweisstrasse 10, Leipzig, Germany. Ulrich.Hegerl@medizin.uni-leipzig.de
Himmerich
Hubertus
H
Engmann
Birk
B
Hensch
Tilman
T
D001289:Attention Deficit Disorder with Hyperactivity / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology* / Q000628:therapy*; D001714:Bipolar Disorder / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology* / Q000628:therapy*; D001921:Brain / Q000503:physiopathology; D039721:Diagnostic and Statistical Manual of Mental Disorders; D006801:Humans