title: Outcome of conservation surgery for laryngeal carcinoma:  an 8-year trial.
abstract: The purpose of this report is to review the experience of our institution with conservative surgery for laryngeal cancer. In this retrospective study, a review was made of 85 patients treated with conservation surgery between 1998 and 2005. At least 2 years of follow-up period (mean 46.6 months) was achieved for all the patients. We evaluated age, tobacco and alcohol intake, T stage, histopathological differentiation and localization of tumor, subglottic extension, anterior commissure invasion, vocal cord mobility, surgical margins, type of surgery applied, and post-operative radiotherapy (pRT) applied. Local control and 2-year survival rates were estimated. We managed with horizontal, vertical, and horizontovertical laryngectomies in 55, 26, and 4 patients, respectively. 28 patients were scheduled to have pRT. The actuarial and overall local control rates were 82.4 and 94.1%, respectively. On univariable analysis, significant factors for increased recurrences were positive resection margins, low differentiation of tumor, alcohol consumption and incompletion of the planned pRT. The 2-year survival rate was 60 and 95.7% for patients with and without local recurrence, respectively. Conservation surgery is a safe procedure for laryngeal cancer in proper endications.
authors.affiliation: Department of Otorhinolaryngology and Head and Neck Surgery, Nizip State Hospital, Ministry of Health, Gaziantep, Turkey. bidem66@hotmail.com
authors.forename: Bilge
authors.initials: B
authors.lastname: Tuna
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Katilmiş
authors.forename: Sedat
authors.initials: S
authors.lastname: Oztürkcan
authors.forename: Ali Ekber
authors.initials: AE
authors.lastname: Ilknur
authors.forename: Riza
authors.initials: R
authors.lastname: Dündar
authors.forename: Yimaz
authors.initials: Y
authors.lastname: Ozkul
authors.forename: Sinem
authors.initials: S
authors.lastname: Aktaş
authors.forename: Filiz
authors.initials: F
authors.lastname: Gülistan
mesh_terms: D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D015331:Cohort Studies; D006801:Humans; D007822:Laryngeal Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D007825:Laryngectomy; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology*; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome