Expression and importance of inhibitor of DNA binding helix-loop-helix protein in salivary adenoid cystic carcinoma.
Studies have reported that Id-1 (inhibitor of DNA binding, or differentiation 1) protein, helix-loop-helix (HLH) transcription factor, has important roles in the development of several carcinomas. However, the role of Id-1 protein in salivary adenoid cystic carcinoma (ACC) is not clear. The expression of Id-1 protein was assessed in formalin-fixed, paraffin-embedded surgical specimens of ACCs by immunohistochemical staining. Thirty-nine of the 54 specimens of ACC stained for Id-1expression, which was significantly more than was found in pleomorphic adenomas (4/12) and normal salivary gland tissues (1/10, p<0.05). There were also significant differences between stages I and II (7/14) and III-IV (32/40) (p<0.05). Of tumours with metastases, 31/38 stained for Id-1, which was significantly higher than among those without metastases (8/16) (p<0.05). Our results showed that Id-1 may have important roles in the development of salivary ACC. It might also be a useful therapeutic tool to help prevent salivary ACC or to inhibit its malignant progression.
Xie
WeiHong
W
Shanghai Key Laboratory of Stomatology, Department of Oral and Maxillofacial Surgery, Ninth People's Hospital, School of Stomatology, Shanghai Jiao Tong University, Shanghai 200011, China.
Li
XinMing
X
Ren
GuoXin
G
Guo
Wei
W
D051792:Basic Helix-Loop-Helix Proteins / Q000037:antagonists & inhibitors; D003528:Carcinoma, Adenoid Cystic / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D016009:Chi-Square Distribution; D003593:Cytoplasm / Q000737:chemistry; D004847:Epithelial Cells / Q000737:chemistry; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D051798:Inhibitor of Differentiation Protein 1 / Q000032:analysis / Q000096:biosynthesis* / Q000235:genetics; D009367:Neoplasm Staging; D012189:Retrospective Studies; D012468:Salivary Gland Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology
D051792:Basic Helix-Loop-Helix Proteins; D051798:Inhibitor of Differentiation Protein 1