Immune response in lung cancer mouse model mimics human anti-Hu reactivity.
Most patients with paraneoplastic encephalomyelitis/sensory neuronopathy PEM/SN have small-cell lung cancer (SCLC) and develop antibodies against neuronal-specific Hu proteins, which are abnormally expressed in the tumor. Anti-Hu reactivity is present in ~16% of SCLC patients without PEM/SN. Here we test the hypothesis that engineered SCLC-prone mice may exhibit anti-Hu reactivity. We show that tumors from SCLC-prone mice misexpress Hu proteins, and 14% of mice harbor anti-Hu antibodies. Mice appear to show reactivity prior to clinical diagnosis of SCLC. This mouse model system will be useful to study SCLC-associated autoimmunity, its diagnostic value, and the potential protective role of oncoantigen-directed autoantibodies.
Kazarian
Meleeneh
M
Departments of Surgery and of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California/Norris Cancer Center, 1441 Eastlake Ave. NOR 6420, Norris Cancer Center, Los Angeles, CA 90089, United States.
Calbo
Joaquim
J
Proost
Natalie
N
Carpenter
Catherine L
CL
Berns
Anton
A
Laird-Offringa
Ite A
IA
D000818:Animals; D000906:Antibodies / Q000097:blood*; D001323:Autoantibodies / Q000276:immunology / Q000378:metabolism; D004195:Disease Models, Animal; D051959:ELAV Proteins / Q000235:genetics / Q000276:immunology*; D006801:Humans; D008156:Luciferases / Q000235:genetics; D008175:Lung Neoplasms / Q000097:blood / Q000276:immunology* / Q000401:mortality; D008279:Magnetic Resonance Imaging; D051379:Mice; D009368:Neoplasm Transplantation / Q000276:immunology; D012333:RNA, Messenger / Q000378:metabolism; D055752:Small Cell Lung Carcinoma / Q000097:blood / Q000276:immunology* / Q000401:mortality; D016019:Survival Analysis; D013997:Time Factors; D019444:Vaccines, DNA / Q000276:immunology
D000906:Antibodies; D001323:Autoantibodies; D051959:ELAV Proteins; D012333:RNA, Messenger; D019444:Vaccines, DNA; D008156:Luciferases