CCR5Delta32 genotype is associated with outcome in type 2 diabetes mellitus.
OBJECTIVE
To test whether the genetic variant CCR5Delta32 in the CC-chemokine receptor 5, which is known to lead to CCR5 deficiency, is associated with mortality in type 2 diabetes patients.


METHODS
We examined the effect of presence or absence of the CCR5Delta32 on overall and cardiovascular mortality risk in the Zwolle Outpatient Diabetes project Integrating Available Care (ZODIAC) cohort, a type 2 diabetes patient cohort.


RESULTS
We studied 756 patients with a mean duration of follow-up of 5.4 (+/- 1.4) years. 194 patients died during follow up of which 83 were cardiovascular deaths. 144 subjects (19%) carried the CCR5Delta32 deletion. CCR5Delta32 carriers had an adjusted hazard ratio of 0.62 (95%CI: 0.40-0.96; p=0.03) for all-cause mortality and 0.63 (95%CI: 0.33-1.19; p=0.16) for cardiovascular mortality.


CONCLUSIONS
The presence of CCR5Delta32 is associated with better survival in type 2 diabetes patients. These data suggest that it is worthwhile to explore the protective potential of pharmacological blockade of CCR5 in type 2 diabetic patients.
Muntinghe
Friso L H
FL
Department of Internal Medicine, University Medical Center Groningen, Groningen, The Netherlands. f.l.h.muntinghe@int.umcg.nl
Gross
Sascha
S
Bakker
Stephan J L
SJ
Landman
Gijs W D
GW
van der Harst
Pim
P
Bilo
Henk J G
HJ
Navis
Gerjan
G
Zuurman
Mike W
MW
D017668:Age of Onset; D000368:Aged; D001794:Blood Pressure; D002318:Cardiovascular Diseases / Q000235:genetics / Q000401:mortality; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics* / Q000401:mortality / Q000628:therapy; D003925:Diabetic Angiopathies / Q000235:genetics / Q000401:mortality; D005260:Female; D005500:Follow-Up Studies; D014644:Genetic Variation; D005838:Genotype; D005919:Glomerular Filtration Rate; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D010045:Outpatients; D019713:Receptors, CCR5 / Q000235:genetics*; D017741:Survivors / Q000706:statistics & numerical data; D016896:Treatment Outcome
D006442:Glycated Hemoglobin; D019713:Receptors, CCR5