title: [Preparation and characterization of artemether-iron sucrose lipid nanoparticles].
abstract: OBJECTIVE
  To prepare Artemether-Iron Sucrose lipid nanoparticles and examine the characteristics of the nanoparticles.
  
  
  METHODS
  The Artemether-Iron Sucrose lipid nanoparticles were prepared by film-dispersing and high-pressure homegenization technique using soybean phospholipid and soybean oil as matrix. The entrapment efficiency and drug loading capacity were determined by HPLC. The morphology was examined by transmission electron microscope and the mean particle size was measured by laser light scattering technique.
  
  
  RESULTS
  The products were spherical and well distributed. The mean diameter was (161+/-17.4) nm with (85.1+/-0.83)% of entrapment efficiency and (5.3+/-0.2)% of drug loading. The in vitro release test showed that the Art-IS-NLC had good sustained release characteristics.
  
  
  CONCLUSIONS
  The preparation method of Art-IS-NLC is simple and feasible. The products are well distributed with a high entrapment efficiency.
authors.affiliation: Key Laboratory of Durg Targeting and Drug Delivery System, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Yan
authors.forename: Zhi-Rong
authors.initials: ZR
authors.lastname: Zhang
authors.forename: Jie
authors.initials: J
authors.lastname: Liu
authors.forename: Tao
authors.initials: T
authors.lastname: Gong
mesh_terms: D000077549:Artemether; D037621:Artemisinins / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000138:chemical synthesis*; D004337:Drug Carriers; D004339:Drug Compounding / Q000379:methods; D007501:Iron / Q000737:chemistry*; D053758:Nanoparticles; D010743:Phospholipids / Q000737:chemistry; D013025:Glycine max / Q000737:chemistry; D013395:Sucrose / Q000737:chemistry*
chemical_list: D037621:Artemisinins; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D010743:Phospholipids; D013395:Sucrose; D000077549:Artemether; D007501:Iron