Neuropsychological functioning in early-onset first-episode psychosis: comparison of diagnostic subgroups.
The aims of this study were to examine the nature and extent of cognitive impairment in first-episode early-onset psychosis (FE-EOP) soon after their stabilisation and to search for potential differences according to specific diagnostic sub-groups of patients. As part of a Spanish multicentre longitudinal study, 107 FE-EOP patients and 98 healthy controls were assessed on the following cognitive domains: attention, working memory, executive functioning, and verbal learning and memory. Three diagnostic categories were established in the patient sample: schizophrenia (n = 36), bipolar disorder (n = 19), and other psychosis (n = 52). Patients performed significantly worse than controls in all cognitive domains. The three diagnostic sub-groups did not differ in terms of impaired/preserved cognitive functions or degree of impairment. FE-EOP patients show significant cognitive impairment that, during this early phase, seems to be non-specific to differential diagnosis.
Zabala
Arantzazu
A
Adolescent Unit, Department of Psychiatry, Hospital General Universitario Gregorio Marañón, c/Ibiza 43, 28009, Madrid, Spain. azabala@mce.hggm.es
Rapado
Marta
M
Arango
Celso
C
Robles
Olalla
O
de la Serna
Elena
E
González
Cristina
C
Rodríguez-Sánchez
José Manuel
JM
Andrés
Patricia
P
Mayoral
María
M
Bombín
Igor
I
D000293:Adolescent; D000704:Analysis of Variance; D001288:Attention / Q000502:physiology; D002648:Child; D003072:Cognition Disorders / Q000145:classification / Q000175:diagnosis* / Q000209:etiology*; D056344:Executive Function / Q000502:physiology; D006801:Humans; D008137:Longitudinal Studies; D008570:Memory, Short-Term / Q000502:physiology; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000150:complications* / Q000175:diagnosis* / Q000523:psychology; D012189:Retrospective Studies; D013030:Spain; D018709:Statistics, Nonparametric