Tea consumption and risk of endometrial cancer: a metaanalysis.
OBJECTIVE
The objective of the study was to assess the association between tea consumption and endometrial cancer.


METHODS
Studies were identified by searching PubMed and EMBASE databases and screening the references of retrieved articles. The summary relative risk (RR) with 95% confidence interval (CI) was calculated.


RESULTS
The combined RR for ever drinkers vs non/lowest drinkers was 0.85 (95% CI, 0.77-0.94). Compared with non/lowest drinkers, the summary RR was 0.88 (95% CI, 0.78-0.98) for low to moderate drinkers and 0.75 (95% CI, 0.64-0.88) for high drinkers. An increase in tea intake of 2 cups/day was associated with a 25% decreased risk of endometrial cancer. In subgroup analyses, tea consumption was significantly associated with reduced endometrial cancer risk in Asian studies and studies using interviewing techniques. Furthermore, the protective effect of green tea on endometrial cancer seemed more evident than that of black tea.


CONCLUSIONS
Findings from this metaanalysis suggest that tea consumption may reduce the risk of endometrial cancer. Because of the limited number of studies, further prospective studies are needed to explore the protective effect of tea on endometrial cancer.
Tang
Na-Ping
NP
National Shanghai Center for New Drug Safety Evaluation and Research, Shanghai Institute of Pharmaceutical Industry, Pudong, Shanghai, China. naping.tang@gmail.com
Li
Hua
H
Qiu
Yun-Liang
YL
Zhou
Guo-Min
GM
Ma
Jing
J
D001628:Beverages; D016022:Case-Control Studies; D015331:Cohort Studies; D016889:Endometrial Neoplasms / Q000235:genetics / Q000517:prevention & control*; D005260:Female; D006801:Humans; D012307:Risk Factors; D013662:Tea
D013662:Tea