title: Association of TNF-alpha gene polymorphisms with systemic lupus erythematosus in Taiwanese patients.
abstract: Tumour necrosis factor-alpha (TNF-alpha), an important proinflammatory cytokine, exerts a variety of physiological and pathogenic effects that lead to tissue destruction. Studies on the association of TNF-alpha genetic polymorphisms with systemic lupus erythematosus (SLE) have yielded inconclusive results. We investigated the association of TNF-alpha genetic polymorphisms (-1031T/C, -863C/A, -857T/C, -308A/G and +489A/G) with SLE in Taiwanese patients and controls. Our results indicate that 1) the frequency of the A-allele at -863 position was significantly higher in SLE patients (odds ratio = 1.46; 95% CI = 1.02-2.08); 2) the frequency of the A-allele at +489 position was significantly higher in SLE patients (odds ratio = 1.79; 95% CI = 1.21-2.65); 3) the AA or GA genotype frequencies at +489 position were significantly increased in SLE patients (AA genotype: odds ratio = 11.20; 95% CI = 1.36-92.55; GA genotype: odds ratio = 1.63; 95% CI = 1.03-2.58); 4) no significant association of TNF-alpha haplotypic distributions was observed, except for the haplotypes TCCGA, CACGA and CCCGG; and 5) the genotype frequency of the polymorphisms at -1031 was significantly different in patients with antinuclear antibodies (P = 0.022). The allele and genotype frequencies of the polymorphisms at -863 were not significantly different. The genotype frequency of the polymorphisms at -857 was significantly different in patients with haematological disorder (P = 0.025). The frequency of A allele of the polymorphisms at -308 was significantly increased in patients with malar rash (P = 0.033), discoid rash (P = 0.023), photosensitivity (P = 0.037), oral ulcers (P = 0.002) and serositis (P = 0.029). The genotype frequency of the polymorphisms at +489 was significantly different in patients with discoid rash and photosensitivity (data not shown; discoid rash, P = 0.031; photosensitivity, P = 0.044). These results suggest that TNF-alpha genetic polymorphisms contribute to SLE susceptibility in the Taiwanese population.
authors.affiliation: Department of Medical Research, China Medical University Hospital, Taichung, Taiwan. yjlin@mail.cmu.edu.tw
authors.forename: Y-J
authors.initials: YJ
authors.lastname: Lin
authors.forename: R-H
authors.initials: RH
authors.lastname: Chen
authors.forename: L
authors.initials: L
authors.lastname: Wan
authors.forename: Jj-C
authors.initials: JC
authors.lastname: Sheu
authors.forename: C-M
authors.initials: CM
authors.lastname: Huang
authors.forename: C-W
authors.initials: CW
authors.lastname: Lin
authors.forename: S-Y
authors.initials: SY
authors.lastname: Chen
authors.forename: C-H
authors.initials: CH
authors.lastname: Lai
authors.forename: Y-C
authors.initials: YC
authors.lastname: Lan
authors.forename: K-C
authors.initials: KC
authors.lastname: Hsueh
authors.forename: C-H
authors.initials: CH
authors.lastname: Tsai
authors.forename: T-H
authors.initials: TH
authors.lastname: Lin
authors.forename: Y-M
authors.initials: YM
authors.lastname: Huang
authors.forename: K
authors.initials: K
authors.lastname: Chao
authors.forename: D-Y
authors.initials: DY
authors.lastname: Chen
authors.forename: F-J
authors.initials: FJ
authors.lastname: Tsai
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics* / Q000276:immunology* / Q000503:physiopathology; D011110:Polymorphism, Genetic; D013624:Taiwan; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
chemical_list: D014409:Tumor Necrosis Factor-alpha