title: Discontinuation of hormone therapy in the French GAZEL cohort 1990-2006.
abstract: OBJECTIVE
  To analyze changes in hormone therapy (HT) use after the publication of the Women's Health Initiative (WHI) results, in a country (France) where HT is different from that assessed in the WHI.
  
  
  METHODS
  Longitudinal study.
  
  
  METHODS
  Women in the GAZEL cohort of employees of the French national power company.
  
  
  METHODS
  One thousand six hundred five postmenopausal women ever-users of HT.
  
  
  METHODS
  None.
  
  
  METHODS
  Discontinuation of HT.
  
  
  RESULTS
  Rates of discontinuation were higher after 2002: 65% of users who began HT in 1998 were still using it after 5 years. In contrast, >90% of those who began before 1994 were still using it after 5 years. Discontinuation was associated with women's social and medical characteristics and with factors related to side effects and expectations concerning HT. After adjustment for these factors, women were twice as likely to stop HT after publication of the WHI.
  
  
  CONCLUSIONS
  Even in France, publication of the WHI has led to a decline in HT use.
authors.affiliation: Institut National d'Etudes Démographiques (INED), Le Kremlin-Bicêtre, France; Institut National de la Santé et de la Recherche Médicale (INSERM), Le Kremlin-Bicêtre, France; University Paris-Sud 11, Faculté de médecine Paris-Sud, Bicêtre Hospital, Le Kremlin-Bicêtre, France. Electronic address: virginie.ringa@inserm.fr.
authors.forename: Virginie
authors.initials: V
authors.lastname: Ringa
authors.affiliation: INSERM, U953, IFR69, Villejuif, France; University Pierre-et-Marie-Curie Paris 6, Paris, France.
authors.forename: Xavier
authors.initials: X
authors.lastname: Fritel
authors.affiliation: Institut National d'Etudes Démographiques (INED), Le Kremlin-Bicêtre, France; Institut National de la Santé et de la Recherche Médicale (INSERM), Le Kremlin-Bicêtre, France; University Paris-Sud 11, Faculté de médecine Paris-Sud, Bicêtre Hospital, Le Kremlin-Bicêtre, France.
authors.forename: Noëlle
authors.initials: N
authors.lastname: Varnoux
authors.affiliation: INSERM, U687, Saint-Maurice, France; Equipe Risques Post-Professionnels-Cohortes (RPPC) du Centre technique d'appui et de formation des centres d'examens de santé (CETAF), Saint-Maurice and Institut Fédératif de Recherche (IFR69), Villejuif, France.
authors.forename: Marie
authors.initials: M
authors.lastname: Zins
authors.affiliation: Institut National d'Etudes Démographiques (INED), Le Kremlin-Bicêtre, France; Institut National de la Santé et de la Recherche Médicale (INSERM), Le Kremlin-Bicêtre, France; University Paris-Sud 11, Faculté de médecine Paris-Sud, Bicêtre Hospital, Le Kremlin-Bicêtre, France.
authors.forename: Céline
authors.initials: C
authors.lastname: Quelen
authors.affiliation: Institut National d'Etudes Démographiques (INED), Le Kremlin-Bicêtre, France; Institut National de la Santé et de la Recherche Médicale (INSERM), Le Kremlin-Bicêtre, France; University Paris-Sud 11, Faculté de médecine Paris-Sud, Bicêtre Hospital, Le Kremlin-Bicêtre, France.
authors.forename: Jean
authors.initials: J
authors.lastname: Bouyer
mesh_terms: D000328:Adult; D015331:Cohort Studies; D015914:Estrogen Replacement Therapy / Q000009:adverse effects / Q000706:statistics & numerical data*; D005260:Female; D005602:France; D006801:Humans; D008137:Longitudinal Studies; D008593:Menopause / Q000187:drug effects; D008875:Middle Aged; D010349:Patient Compliance / Q000706:statistics & numerical data; D010353:Patient Education as Topic; D011210:Power Plants; D011795:Surveys and Questionnaires; D028761:Withholding Treatment / Q000706:statistics & numerical data*; D016387:Women's Health