title: Association of IL-15 polymorphisms with bone mineral density in postmenopausal Korean women.
abstract: Interleukin-15 (IL-15) has been suggested to participate in bone metabolism by stimulating osteoclast differentiation and mediating inflammatory bone loss. This study investigated the effect of IL-15 gene polymorphisms on the bone mineral density (BMD) and bone fracture rates of postmenopausal women. Sequencing of the IL-15 gene in 24 Koreans revealed 16 single-nucleotide polymorphisms (SNPs), of which five were selected for further study. Postmenopausal Korean women (n = 844) were genotyped for these SNPs, and their BMDs and risk of fractures were assessed. It was found that the +20A > G, +13467C > A, +13653A > T, and +13815A > T IL-15 gene polymorphisms were significantly associated with the BMD of the lumbar spine and femoral neck and that their effects were gene-dose dependent. BMD was reduced when the minor allele of +13467A and +13653T or the common allele of +20A and +13815A was present. Haplotype (ht) analyses revealed that ht1 (GCAT) and ht2 (AATA) were associated with BMD of the lumbar spine and femoral neck. However, there was no association between the risk of fracture and IL-15 SNPs or hts. These results suggest that the +20A > G, +13467C > A, +13653A > T, and +13815A > T SNPs in the IL-15 gene affect BMD and, thus, could be genetic markers of osteoporosis.
authors.affiliation: Skeletal Diseases Genome Research Center, Kyungpook National University Hospital, Daegu 700-412, Korea.
authors.forename: Jung-Min
authors.initials: JM
authors.lastname: Koh
authors.forename: Bermseok
authors.initials: B
authors.lastname: Oh
authors.forename: Mi-Hyun
authors.initials: MH
authors.lastname: Ha
authors.forename: Kyu-Woan
authors.initials: KW
authors.lastname: Cho
authors.forename: Jong-Young
authors.initials: JY
authors.lastname: Lee
authors.forename: Byung Lae
authors.initials: BL
authors.lastname: Park
authors.forename: Hyoung Doo
authors.initials: HD
authors.lastname: Shin
authors.forename: Myung-Ae
authors.initials: MA
authors.lastname: Bae
authors.forename: Hyun-Ju
authors.initials: HJ
authors.lastname: Kim
authors.forename: Jung Min
authors.initials: JM
authors.lastname: Hong
authors.forename: Tae-Ho
authors.initials: TH
authors.lastname: Kim
authors.forename: Hong-In
authors.initials: HI
authors.lastname: Shin
authors.forename: Seung Hun
authors.initials: SH
authors.lastname: Lee
authors.forename: Ghi Su
authors.initials: GS
authors.lastname: Kim
authors.forename: Shin-Yoon
authors.initials: SY
authors.lastname: Kim
authors.forename: Eui Kyun
authors.initials: EK
authors.lastname: Park
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D015519:Bone Density / Q000235:genetics*; D005260:Female; D005272:Femur Neck / Q000378:metabolism; D050723:Fractures, Bone / Q000235:genetics*; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D019409:Interleukin-15 / Q000235:genetics*; D007723:Korea; D008159:Lumbar Vertebrae / Q000378:metabolism; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D005819:Genetic Markers; D019409:Interleukin-15