title: Preventing viral-induced type 1 diabetes.
abstract: The development of type 1 diabetes is, in part, dictated by the failure of regulatory T cells to maintain peripheral tolerance. As such, therapies aimed at correcting the declining function of regulatory T cells have been the subject of intense investigation. In this review, we discuss the potential of regulatory T cells to suppress autoreactive responses and prevent type 1 diabetes induced by viral infection while maintaining protective antiviral immunity.
authors.affiliation: Department of Microbiology and Immunology, The University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: Martin Joseph
authors.initials: MJ
authors.lastname: Richer
authors.forename: Marc Steven
authors.initials: MS
authors.lastname: Horwitz
mesh_terms: D000818:Animals; D015551:Autoimmunity / Q000187:drug effects / Q000276:immunology; D017252:CD3 Complex / Q000276:immunology; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology / Q000276:immunology* / Q000517:prevention & control; D006801:Humans; D016853:Muromonab-CD3 / Q000627:therapeutic use; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects / Q000276:immunology*; D014777:Virus Diseases / Q000150:complications / Q000276:immunology* / Q000517:prevention & control
chemical_list: D017252:CD3 Complex; D016853:Muromonab-CD3