title: A colorimetric and fluorescent merocyanine-based probe for biological thiols.
abstract: A new "dual-mode" chromogenic and fluorescent turn-on probe (2) for the selective sensing of biological thiols is reported. In MeOH-H(2)O cosolvent at physiological pH 7.40 (MeOH-H(2)O = 3:7), biological thiols cleave the 2,4-dinitrobenzenesulfonyl group to release the chromo- and fluorophore merocyanine (3).
authors.affiliation: Department of Chemistry and The Key Laboratory of Analytical Sciences of MOE, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, PR China.
authors.forename: Shu-Ping
authors.initials: SP
authors.lastname: Wang
authors.forename: Wu-Jian
authors.initials: WJ
authors.lastname: Deng
authors.forename: Dan
authors.initials: D
authors.lastname: Sun
authors.forename: Min
authors.initials: M
authors.lastname: Yan
authors.forename: Hong
authors.initials: H
authors.lastname: Zheng
authors.forename: Jin-Gou
authors.initials: JG
authors.lastname: Xu
mesh_terms: D003124:Colorimetry; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D011744:Pyrimidinones / Q000138:chemical synthesis / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet; D013438:Sulfhydryl Compounds / Q000032:analysis* / Q000737:chemistry
chemical_list: D005456:Fluorescent Dyes; D011744:Pyrimidinones; D013438:Sulfhydryl Compounds; C003954:merocyanine dye