Telemetric analysis to detect febrile responses in mice following vaccination with a live-attenuated virus vaccine.
Non-human primates (NHP) are considered to be the most appropriate model for predicting how humans will respond to many infectious diseases. Due to ethical and monetary concerns associated with the use of NHP, rodent models that are as predictive of responses likely to be seen in human vaccine recipients are warranted. Using implanted telemetry devices, body temperature and activity were monitored in inbred and outbred mouse strains following administration of the live-attenuated vaccine for Venezuelan equine encephalitis virus (VEEV), V3526. Following analysis of individual mouse data, only outbred mouse strains showed changes in diurnal temperature and activity profiles following vaccination. Similar changes were observed following VEEV challenge of vaccinated outbred mice. From these studies, we conclude, outbred mouse strains implanted with telemeters are a sensitive model for predicting responses in humans following vaccination.
Martin
Shannon S
SS
DynPort Vaccine Company LLC (DVC), A CSC Company, Frederick, MD 21702, USA. smartin40@csc.com
Bakken
Russell R
RR
Lind
Cathleen M
CM
Reed
Douglas S
DS
Price
Jessica L
JL
Koeller
Craig A
CA
Parker
Michael D
MD
Hart
Mary Kate
MK
Fine
Donald L
DL
D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D001522:Behavior, Animal; D001831:Body Temperature; D001835:Body Weight; D004195:Disease Models, Animal; D004666:Encephalitis Virus, Venezuelan Equine / Q000276:immunology; D004685:Encephalomyelitis, Venezuelan Equine / Q000517:prevention & control; D005260:Female; D005334:Fever / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D009500:Neutralization Tests; D012680:Sensitivity and Specificity; D013686:Telemetry; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000276:immunology; D014765:Viral Vaccines / Q000008:administration & dosage / Q000276:immunology*
D000914:Antibodies, Viral; D014613:Vaccines, Attenuated; D014765:Viral Vaccines