Experimental diabetes mellitus: oxidative stress and changes in lung structure.
Diabetes mellitus is an endocrine/metabolic disorder characterized by hyperglycemia. Its impact on the respiratory system is characterized by functional changes and alterations in gas exchange. The objective of this study was to evaluate the increase in oxidative stress and the potential damages to the lung structure in an experimental model of streptozotocin-induced diabetes. We conducted histological, biochemical and blood gas analyses in the lungs of diabetic rats. We concluded that the effects of experimental diabetes mellitus include oxidative stress, structural changes in the lung tissue and altered gas exchange.
Forgiarini
Luiz Alberto
LA
Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil.
Kretzmann
Nélson Alexandre
NA
Porawski
Marilene
M
Dias
Alexandre Simões
AS
Marroni
Norma Anair Possa
NA
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology; D004195:Disease Models, Animal; D008168:Lung / Q000473:pathology / Q000503:physiopathology; D018384:Oxidative Stress / Q000502:physiology*; D011659:Pulmonary Gas Exchange / Q000502:physiology; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin
D013311:Streptozocin