title: Disseminated Cryptococcus neoformans: case report and review of the literature.
abstract: Cryptococcus neoformans is a yeastlike encapsulated basidiomycetous fungus that is able to cross the blood-brain barrier and cause meningitis in both immunocompetent and immunocompromised individuals. Cryptococcus neoformans has emerged as a major opportunistic pathogen because of the widespread use of immunosuppressive therapy. It causes most cryptococcal infections in humans, and disseminated infection can have cutaneous manifestations. We report a rare case of disseminated C neoformans in a 52-year-old man who underwent an orthotopic liver transplant. We also provide a concise review of the literature on C neoformans, including its associations, histology, and treatment.
authors.affiliation: Georgetown University Hospital, Washington, DC, USA.
authors.forename: Nisha C
authors.initials: NC
authors.lastname: Patel
authors.forename: Christopher
authors.initials: C
authors.lastname: Ewanowski
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Kupiec-Banasikowska
authors.forename: Kevin P
authors.initials: KP
authors.lastname: Hogan
mesh_terms: D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D003453:Cryptococcosis / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology*; D003455:Cryptococcus neoformans / Q000302:isolation & purification*; D005437:Flucytosine / Q000627:therapeutic use; D006801:Humans; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B; D005437:Flucytosine