Time-resolved lanthanide luminescence for lab-on-a-chip detection of biomarkers on cancerous tissues.
PDMS-based microfluidic devices combined with lanthanide-based immunocomplexes have been successfully tested for the multiplex detection of biomarkers on cancerous tissues, revealing an enhanced sensitivity compared to classical organic dyes.
Song
Bo
B
Laboratory of Lanthanide Supramolecular Chemistry (LCSL), Ecole Polytechnique Fédérale de Lausanne, BCH 1404, 1015 Lausanne, Switzerland.
Sivagnanam
Venkataragavalu
V
Vandevyver
Caroline D B
CD
Hemmilä
Ilkka
I
Lehr
Hans-Anton
HA
Gijs
Martin A M
MA
Bünzli
Jean-Claude G
JC
D014408:Biomarkers, Tumor / Q000032:analysis* / Q000276:immunology; D045744:Cell Line, Tumor; D004129:Dimethylpolysiloxanes / Q000737:chemistry; D006801:Humans; D007118:Immunoassay; D056656:Lab-On-A-Chip Devices; D028581:Lanthanoid Series Elements / Q000737:chemistry*; D008163:Luminescent Measurements; D009369:Neoplasms / Q000473:pathology*; D013997:Time Factors
D014408:Biomarkers, Tumor; D004129:Dimethylpolysiloxanes; D028581:Lanthanoid Series Elements; C013830:baysilon