G-quadruplex recognition by macrocyclic hexaoxazole (6OTD) dimer.
Telomestatin (TMS: 1) is as a potent and selective telomeric G-quadruplex binder. Two molecules of TMS were suggested to be intercalated to one telomeric G-quadruplex according to docking study. In this paper, we designed and synthesized hexaoxazole TMS derivative (6OTD) dimer, and evaluated its G-quadruplex stabilizing ability.
Iida
Keisuke
K
Department of Biotechnology and Life Science, Faculty of Technology, Tokyo University of Agriculture and Technology and Biological Information Research Center National Institute of Advanced Industrial Science and Techonology, Koganei, Tokyo 184-8588, Japan.
Tera
Masayuki
M
Shin-Ya
Kazuo
K
Nagasawa
Kazuo
K
D004247:DNA / Q000737:chemistry; D031541:Fluorescence Resonance Energy Transfer; D054856:G-Quadruplexes; D010080:Oxazoles / Q000138:chemical synthesis / Q000737:chemistry*; D016615:Telomere / Q000737:chemistry*; D013844:Thiazoles / Q000138:chemical synthesis / Q000737:chemistry*
D010080:Oxazoles; D013844:Thiazoles; C431888:telomestatin; D004247:DNA