title: Highly enantioselective alkylation reaction of enamides by Brønsted-acid catalysis.
abstract: The H8-BINOL-derived, phosphoric acid catalyzed, highly enatioselective alkylation reaction of enamides with indolyl alcohols has been described. A phosphoric acid derived from H8-BINOL enabled an asymmetric alpha-alkylation of enamides with indolyl alcohols to give beta-aryl 3-(3-indolyl)propanones in high yields (up to 96%) and with excellent enantioselectivity (up to 96% ee).
authors.affiliation: School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China. qxguo@swu.edu.cn
authors.forename: Qi-Xiang
authors.initials: QX
authors.lastname: Guo
authors.forename: Yun-Gui
authors.initials: YG
authors.lastname: Peng
authors.forename: Jin-Wei
authors.initials: JW
authors.lastname: Zhang
authors.forename: Liu
authors.initials: L
authors.lastname: Song
authors.forename: Zhang
authors.initials: Z
authors.lastname: Feng
authors.forename: Liu-Zhu
authors.initials: LZ
authors.lastname: Gong