title: Air detoxification with nanosize TiO2 aerosol tested on mice.
abstract: A method for fast air purification using high concentration aerosol of TiO(2) nanoparticles is evaluated in a model chemical catastrophe involving toxic vapors of diisopropyl fluorophosphate (DFP). Mice are used as human model in a closed 100 dm(3) chamber. Exposure of mice to 37 ppm of DFP vapor for 15 min resulted in acute poisoning. Spraying TiO(2) aerosol in 2 min after the start of exposure to DFP vapors resulted in quick removal of DFP vapors from the chamber's air. Animals did not show signs of poisoning after the decontamination experiment and exposure to TiO(2) aerosol alone. Reactive oxygen species (ROS) and antioxidant activity (AOA) of mice blood plasma were measured for animals exposed to sound of aerosol generator, DFP vapors, TiO(2) aerosol and DFP vapors+TiO(2) aerosol. Reduced ROS and increased AOA were found for mice exposure to sound, DFP and TiO(2) aerosol. Exposure to DFP and decontamination with TiO(2) nanoparticles resulted in decreased AOA in 48 h following the exposure. The results suggest that application of TiO(2) aerosol is a powerful method of air purification from toxic hydrolysable compounds with moderate health aftermaths and requires further study and optimization.
authors.affiliation: Boreskov Institute of Catalysis, Novosibirsk 630090, Russia.
authors.forename: A S
authors.initials: AS
authors.lastname: Besov
authors.forename: N A
authors.initials: NA
authors.lastname: Krivova
authors.forename: A V
authors.initials: AV
authors.lastname: Vorontsov
authors.forename: O B
authors.initials: OB
authors.lastname: Zaeva
authors.forename: D V
authors.initials: DV
authors.lastname: Kozlov
authors.forename: A B
authors.initials: AB
authors.lastname: Vorozhtsov
authors.forename: V N
authors.initials: VN
authors.lastname: Parmon
authors.forename: G V
authors.initials: GV
authors.lastname: Sakovich
authors.forename: V F
authors.initials: VF
authors.lastname: Komarov
authors.forename: P G
authors.initials: PG
authors.lastname: Smirniotis
authors.forename: N
authors.initials: N
authors.lastname: Eisenreich
mesh_terms: D000336:Aerosols; D000388:Air / Q000032:analysis*; D000393:Air Pollutants / Q000032:analysis* / Q000633:toxicity*; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001273:Atmosphere Exposure Chambers; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000633:toxicity; D004190:Disasters; D005609:Free Radicals / Q000032:analysis / Q000378:metabolism; D006861:Hydrogen Peroxide / Q000737:chemistry; D007531:Isoflurophate / Q000737:chemistry / Q000633:toxicity; D007700:Kinetics; D049449:Luminescence; D051379:Mice; D053758:Nanoparticles; D016877:Oxidants / Q000737:chemistry; D010316:Particle Size; D013016:Sound; D013055:Spectrophotometry, Infrared; D014025:Titanium / Q000737:chemistry*
chemical_list: D000336:Aerosols; D000393:Air Pollutants; D000975:Antioxidants; D002800:Cholinesterase Inhibitors; D005609:Free Radicals; D016877:Oxidants; D007531:Isoflurophate; C009495:titanium dioxide; D006861:Hydrogen Peroxide; D014025:Titanium