title: The effect of total extract of Securigera securidaca L. seeds on serum lipid profiles, antioxidant status, and vascular function in hypercholesterolemic rats.
abstract: OBJECTIVE
  Seeds of Securigera securidaca are used for the treatment of disorders such as hyperlipidemia, diabetes, and epilepsy in Iranian folk medicine. The possible hypolipidemic and antioxidative effects of hydroalcoholic extract of S. securidaca seeds as well as the effect of the extract on vascular reactivity were investigated in hypercholesterolemic rats.
  
  
  METHODS
  High-fat fed wistar rats received orally different doses of the extract for 20 days. At the end of the experiment vein blood and liver were collected to measure the lipid profile, lipid peroxidation, and antioxidative enzyme activities. The thoracic aorta was excised and used for isolated vessel preparation and histological study.
  
  
  RESULTS
  The extract produced significant reductions (p<0.05) in the level of low-density lipoprotein (LDL) and triglyceride with concomitant reduction in lipid deposition in the liver. The extract also suppressed markedly (p<0.001) the hypercholesterolemia-induced elevation of malondialdehyde levels both in serum and liver. In hypercholesterolemic rats the endothelium-dependent vasodilatation was improved significantly (p<0.05) by 100mg/kg/day of the extract. However, in histological study no atherosclerotic lesion was observed.
  
  
  CONCLUSIONS
  These results suggest that S. securidaca seed in addition to decrease lipid levels and peroxidation, is able to improve vascular endothelium-dependent relaxation in hypercholesterolemia.
authors.affiliation: Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran. garjania2002@yahoo.com
authors.forename: Alireza
authors.initials: A
authors.lastname: Garjani
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Fathiazad
authors.forename: Arezoo
authors.initials: A
authors.lastname: Zakheri
authors.forename: Negar Allaf
authors.initials: NA
authors.lastname: Akbari
authors.forename: Yadollah
authors.initials: Y
authors.lastname: Azarmie
authors.forename: Ashraf
authors.initials: A
authors.lastname: Fakhrjoo
authors.forename: Sina
authors.initials: S
authors.lastname: Andalib
authors.forename: Nasrin
authors.initials: N
authors.lastname: Maleki-Dizaji
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D001011:Aorta / Q000378:metabolism / Q000503:physiopathology*; D007887:Fabaceae / Q000737:chemistry* / Q000196:embryology; D006937:Hypercholesterolemia / Q000097:blood / Q000503:physiopathology*; D008055:Lipids / Q000097:blood*; D008099:Liver / Q000378:metabolism; D008297:Male; D010936:Plant Extracts / Q000493:pharmacokinetics / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012639:Seeds / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D008055:Lipids; D010936:Plant Extracts