High temperature zincation of functionalized aromatics and heteroaromatics using TMPZnCl.LiCl and microwave irradiation.
A wide range of functional aryl and heteroaryl zinc reagents have been efficiently prepared via regio- and chemoselective zincation using TMPZnCl.LiCl and microwave irradiation. Sensitive functional groups like esters are compatible with the high temperatures of the reactions. The resulting zinc species undergo a number of subsequent reactions, providing highly functionalized aromatics and heteroaromatics in high yields.
Mosrin
Marc
M
Department Chemie, Ludwig-Maximilians-Universität München, Butenandstrasse 5-13, Haus F, 81377 München, Germany.
Monzon
Gabriel
G
Bresser
Tomke
T
Knochel
Paul
P
D006358:Hot Temperature; D048031:JNK Mitogen-Activated Protein Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism; D018021:Lithium Chloride / Q000737:chemistry*; D008872:Microwaves; D047428:Protein Kinase Inhibitors / Q000737:chemistry; D015032:Zinc / Q000737:chemistry*
D047428:Protein Kinase Inhibitors; D048031:JNK Mitogen-Activated Protein Kinases; D018021:Lithium Chloride; D015032:Zinc