Microencapsulated stem cells for tissue repairing: implications in cell-based myocardial therapy.
Stem cells have the unique properties of self-renewal, pluripotency and a high proliferative capability, which contributes to a large biomass potential. Hence, these cells act as a useful source for acquiring renewable adult cell lines. This, in turn, acts as a potent therapeutic tool to treat various diseases related to the heart, liver and kidney, as well as neurodegenerative diseases such as Parkinson's and Alzheimer's disease. However, a major problem that must be overcome before it can be effectively implemented into the clinical setting is a suitable delivery system that can retain an optimal quantity of the cells at the targeted site for a maximal clinical benefit; a system that will give a mechanical as well as an immune protection to the foreign cells, while at the same time enhancing the yields of differentiated cells, maintaining cell microenvironments and sustaining the differentiated cell functions. To address this issue we opted for a novel delivery system, termed the 'artificial cells', which are semipermeable microcapsules with strong and thin multilayer membrane components with specific mass transport properties. Here, we briefly introduce the concept of artificial cells for encapsulation of stem cells and investigate the application of microencapsulation technology as an ideal tool for all stem transplantations and relate their role to the emerging field of cellular cardiomyoplasty.
Paul
Arghya
A
Biomedical Technology & Cell Therapy Research Laboratory, Department of Biomedical Engineering & Artificial Cells & Organs Research Centre, Faculty of Medicine, McGill University, 3775 University Street, Montreal, Quebec, H3A 2B4, Canada.
Ge
Yin
Y
Prakash
Satya
S
Shum-Tim
Dominique
D
D000818:Animals; D006348:Cardiac Surgical Procedures; D018929:Cell Culture Techniques; D004339:Drug Compounding; D006801:Humans; D009203:Myocardial Infarction / Q000601:surgery; D009206:Myocardium / Q000166:cytology; D051381:Rats; D033581:Stem Cell Transplantation / Q000379:methods*; D013234:Stem Cells / Q000276:immunology