Peroxisomes and peroxisomal disorders: the main facts.
The importance of peroxisomes for human health is highlighted by the number of peroxisomal disorders (PDs), diseases associated to peroxisome biogenesis disorders and peroxisomal enzyme/transporter deficiencies. Currently, many physiological/biosynthetic mechanisms involved in these illnesses have been elucidated, but PDs remain incurable. This review examines the most important aspects concerning peroxisomes (i.e. peroxisome proliferation, peroxisome biogenesis, metabolic functions of mammalian peroxisomes) and presents the most significant trends and advances in the study of peroxisomal disorders.
Fidaleo
Marco
M
Department of Cellular and Developmental Biology, University of Rome La Sapienza, Piazzale Aldo Moro 5, Rome, Italy.
D001647:Bile Acids and Salts / Q000378:metabolism; D049109:Cell Proliferation; D002784:Cholesterol / Q000096:biosynthesis; D005227:Fatty Acids / Q000378:metabolism; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D018901:Peroxisomal Disorders / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D020675:Peroxisomes / Q000502:physiology*; D021381:Protein Transport
D001647:Bile Acids and Salts; D005227:Fatty Acids; D008565:Membrane Proteins; D002784:Cholesterol