Locomotor adaptation and aftereffects in patients with reduced somatosensory input due to peripheral neuropathy.
We studied 12 peripheral neuropathy patients (PNP) and 13 age-matched controls with the "broken escalator" paradigm to see how somatosensory loss affects gait adaptation and the release and recovery ("braking") of the forward trunk overshoot observed during this locomotor aftereffect. Trunk displacement, foot contact signals, and leg electromyograms (EMGs) were recorded while subjects walked onto a stationary sled (BEFORE trials), onto the moving sled (MOVING or adaptation trials), and again onto the stationary sled (AFTER trials). PNP were unsteady during the MOVING trials, but this progressively improved, indicating some adaptation. During the after trials, 77% of control subjects displayed a trunk overshoot aftereffect but over half of the PNP (58%) did not. The PNP without a trunk aftereffect adapted to the MOVING trials by increasing distance traveled; subsequently this was expressed as increased distance traveled during the aftereffect rather than as a trunk overshoot. This clear separation in consequent aftereffects was not seen in the normal controls suggesting that, as a result of somatosensory loss, some PNP use distinctive strategies to negotiate the moving sled, in turn resulting in a distinct aftereffects. In addition, PNP displayed earlier than normal anticipatory leg EMG activity during the first after trial. Although proprioceptive inputs are not critical for the emergence or termination of the aftereffect, somatosensory loss induces profound changes in motor adaptation and anticipation. Our study has found individual differences in adaptive motor performance, indicative that PNP adopt different feed-forward gait compensatory strategies in response to peripheral sensory loss.
Bunday
Karen L
KL
Department of Clinical Neurosciences, Division of Neuroscience and Mental Health, Imperial College London, Charing Cross Hospital, London, UK.
Bronstein
Adolfo M
AM
D000222:Adaptation, Physiological / Q000502:physiology*; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D016022:Case-Control Studies; D004576:Electromyography / Q000379:methods; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D005684:Gait; D006801:Humans; D008297:Male; D008875:Middle Aged; D010523:Peripheral Nervous System Diseases / Q000503:physiopathology* / Q000523:psychology; D004856:Postural Balance / Q000502:physiology; D011434:Proprioception / Q000502:physiology*; D016138:Walking / Q000502:physiology*