title: Further evidence for the association between attention deficit/hyperactivity disorder and the serotonin receptor 1B gene.
abstract: Several evidences suggested that the serotonin 5-HT1B receptor gene (HRT1B) might be involved in the susceptibility to attention deficit/hyperactivity disorder (ADHD). Prior studies reported excess transmissions of the HRT1B gene 861G allele to affected ADHD children and of a haplotype block containing this variant and two functional promoter SNPs to probands with ADHD-inattentive subtype. However, some investigations did not replicate these findings. Therefore, we tested for biased transmissions of haplotypes derived from the 861G > C, -161A > T, and -261T > G SNPs from parents to 343 families with ADHD children. We also sought to replicate findings from the literature that the association between HTR1B is preferentially with ADHD-Inattentive subtype. Using a transmission disequilibrium test we found evidence for an excess transmission of haplotype. -261G/-161T/861G (P = 0.014) for affected children in the total sample. When the analysis was repeated with 143 families with ADHD-Inattentive subtype no significant associations were observed. Our results provide additional evidence that HRT1B gene may be an important risk factor for the development of ADHD, but this effect seems not to be attributable to inattentive cases.
authors.affiliation: Departamento de Genética, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Caixa Postal 15053, Porto Alegre, RS 91501-970, Brazil.
authors.forename: Ana P
authors.initials: AP
authors.lastname: Guimarães
authors.forename: Marcelo
authors.initials: M
authors.lastname: Schmitz
authors.forename: Guilherme V
authors.initials: GV
authors.lastname: Polanczyk
authors.forename: Cristian
authors.initials: C
authors.lastname: Zeni
authors.forename: Julia
authors.initials: J
authors.lastname: Genro
authors.forename: Tatiana
authors.initials: T
authors.lastname: Roman
authors.forename: Luis A
authors.initials: LA
authors.lastname: Rohde
authors.forename: Mara H
authors.initials: MH
authors.lastname: Hutz
mesh_terms: D001289:Attention Deficit Disorder with Hyperactivity / Q000453:epidemiology / Q000235:genetics*; D002648:Child; D005190:Family; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D008297:Male; D010290:Parents; D020641:Polymorphism, Single Nucleotide; D044302:Receptor, Serotonin, 5-HT1B / Q000235:genetics*; D012307:Risk Factors; D017422:Sequence Analysis, DNA
chemical_list: D044302:Receptor, Serotonin, 5-HT1B