title: Synergistic effects of elevated systolic blood pressure and hypercholesterolemia on carotid intima-media thickness in children and adolescents.
abstract: This study aimed to investigate the synergistic effects of elevated systolic blood pressure (SBP) and hypercholesterolemia on carotid intima-media thickness (cIMT). For this study, 60 children with hypercholesterolemia and 40 healthy control children were divided into four subgroups: hypercholesterolemic children with normal (<90th percentile) or elevated (>or= 90th percentile) SBP and control children with normal or elevated SBP. The highest mean and maximal cIMT values were found in the hypercholesterolemic children with elevated SBP and were significantly different from those of all the other groups. The synergistic effects of elevated SBP and hypercholesterolemia lead to a significant increase in cIMT as a subclinical sign of early atherosclerosis.
authors.affiliation: Department of Pediatrics and Adolescents Medicine, University Hospital, Mathilden Street 1, 79106 Freiburg, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Krebs
authors.forename: Arno
authors.initials: A
authors.lastname: Schmidt-Trucksäss
authors.forename: Janine
authors.initials: J
authors.lastname: Alt
authors.forename: Jürgen
authors.initials: J
authors.lastname: Doerfer
authors.forename: Kristin
authors.initials: K
authors.lastname: Krebs
authors.forename: Karl
authors.initials: K
authors.lastname: Winkler
authors.forename: Karl Otfried
authors.initials: KO
authors.lastname: Schwab
mesh_terms: D000293:Adolescent; D001794:Blood Pressure; D015992:Body Mass Index; D002339:Carotid Arteries / Q000000981:diagnostic imaging / Q000473:pathology*; D002340:Carotid Artery Diseases / Q000473:pathology*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005260:Female; D005858:Germany / Q000453:epidemiology; D006305:Health Status Indicators; D006801:Humans; D006937:Hypercholesterolemia / Q000150:complications / Q000473:pathology*; D006973:Hypertension / Q000150:complications / Q000473:pathology*; D008297:Male; D017539:Tunica Intima / Q000000981:diagnostic imaging / Q000473:pathology*; D017540:Tunica Media / Q000000981:diagnostic imaging / Q000473:pathology*; D014463:Ultrasonography