[Ulcers following therapy with hydroxyurea. Three case reports and review of the literature].
Hydroxyurea is frequently used for therapy of myeloproliferative disorders. One cutaneous side-effect is painful, therapy-resistant ulcers which have bizarre configurations and occur at atypical sites for venous ulcers. Improvement or healing often first occurs when hydroxyurea is discontinued. We report on one patient with essential thrombocythemia and two with polycythemia vera, who developed such ulcers during hydroxyurea therapy. In one case, the ulcers developed shortly after hydroxyurea was started. In addition we give a short overview of the current literature.
Boneberger
S
S
Klinik und Poliklinik für Dermatologie und Allergologie, Ludwig-Maximilians-Universität München, Frauenlobstr. 9-11, 80337, München, Deutschland. Susanne.Boneberger@med.uni-muenchen.de
Rupec
R A
RA
Ruzicka
T
T
D000368:Aged; D000986:Antisickling Agents / Q000008:administration & dosage / Q000009:adverse effects; D001791:Blood Platelet Disorders / Q000150:complications / Q000188:drug therapy; D005260:Female; D006801:Humans; D006918:Hydroxyurea / Q000009:adverse effects* / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009196:Myeloproliferative Disorders / Q000150:complications* / Q000188:drug therapy*; D014456:Ulcer / Q000139:chemically induced* / Q000517:prevention & control*
D000986:Antisickling Agents; D006918:Hydroxyurea