A novel picornavirus associated with gastroenteritis.
A novel picornavirus genome was sequenced, showing 42.6%, 35.2%, and 44.6% of deduced amino acid identities corresponding to the P1, P2, and P3 regions, respectively, of the Aichi virus. Divergent strains of this new virus, which we named salivirus, were detected in 18 stool samples from Nigeria, Tunisia, Nepal, and the United States. A statistical association was seen between virus shedding and unexplained cases of gastroenteritis in Nepal (P = 0.0056). Viruses with approximately 90% nucleotide similarity, named klassevirus, were also recently reported in three cases of unexplained diarrhea from the United States and Australia and in sewage from Spain, reflecting a global distribution and supporting a pathogenic role for this new group of picornaviruses.
Li
Linlin
L
Blood Systems Research Institute, San Francisco, CA 94118, USA.
Victoria
Joseph
J
Kapoor
Amit
A
Blinkova
Olga
O
Wang
Chunlin
C
Babrzadeh
Farbod
F
Mason
Carl J
CJ
Pandey
Prativa
P
Triki
Hinda
H
Bahri
Olfa
O
Oderinde
Bamidele Soji
BS
Baba
Marycelin Mandu
MM
Bukbuk
David Nadeba
DN
Besser
John M
JM
Bartkus
Joanne M
JM
Delwart
Eric L
EL
D000595:Amino Acid Sequence; D001483:Base Sequence; D005759:Gastroenteritis / Q000821:virology*; D016679:Genome, Viral / Q000235:genetics; D006801:Humans; D008969:Molecular Sequence Data; D010802:Phylogeny; D010849:Picornaviridae / Q000235:genetics*; D010850:Picornaviridae Infections / Q000821:virology*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014764:Viral Proteins / Q000235:genetics
D014764:Viral Proteins