title: Acute liver failure due to concomitant arterial, portal and biliary injury during laparoscopic cholecystectomy: is transplantation a valid life-saving strategy? A case report.
abstract: BACKGROUND
  Combined iatrogenic vascular and biliary injury during cholecystectomy resulting in ischemic hepatic necrosis is a very rare cause of acute liver failure. We describe a patient who developed fulminant liver failure as a result of severe cholestasis and liver gangrene secondary to iatrogenic combine injury or the hepatic pedicle (i.e. hepatic artery, portal vein and bile duct) during laparoscopic cholecystectomy.
  
  
  METHODS
  A 40-years-old woman underwent laparoscopic cholecystectomy for acute cholecystitis. During laparoscopy, a severe bleeding at the liver hilum motivated the conversion to open surgery. Many sutures were placed across the parenchyma for bleeding control. After 48 hours, she rapidly deteriorated with encephalopathy, coagulopathy, persistent hypotension and progressive organ dysfunction including acute renal failure requiring hemodialysis and mechanical ventilation. An angiography documented an occlusion of right hepatic artery and right portal vein. In the clinical of acute liver failure secondary to liver gangrene, severe coagulopathy and progressive secondary multi-organ failure, the patient was included in the waiting list for liver transplantation. Two days later, the patient was successfully transplanted with initial adequate liver graft function. However, she developed bilateral pneumonia and severe gastrointestinal bleeding and finally died 24 days after transplantation due to bilateral necrotizing pneumonia.
  
  
  CONCLUSIONS
  The occurrence of acute liver failure due to portal triad injury during laparoscopic cholecystectomy is a catastrophic complication. Probably, the indication of liver transplantation as a life-saving strategy in patients with late diagnosis, acute liver failure, severe coagulopathy and progressive secondary multi-organ failure could be considered but only minimizing immunosuppressive regimen to avoid postoperative infections.
authors.affiliation: The Hepato-Pancreato-Biliary and Liver Transplantation Unit, General Surgery Service, Hospital Aleman from Buenos Aires, Argentina. lmccormack@hospitalaleman.com.
authors.forename: Lucas
authors.initials: L
authors.lastname: McCormack
authors.forename: Emilio G
authors.initials: EG
authors.lastname: Quiñonez
authors.forename: Pablo
authors.initials: P
authors.lastname: Capitanich
authors.forename: Sara
authors.initials: S
authors.lastname: Chao
authors.forename: Victor
authors.initials: V
authors.lastname: Serafini
authors.forename: Nicolas
authors.initials: N
authors.lastname: Goldaracena
authors.forename: Ricardo C
authors.initials: RC
authors.lastname: Mastai