title: [Changes of insulin resistance and islet beta cells function in subjects with high-normal blood pressure].
abstract: OBJECTIVE
  To investigate the changes of insulin resistance and islet beta cells function in subjects with euglycemia and high-normal blood pressure.
  
  
  METHODS
  Total 423 subjects were divided into normal blood pressure group and high-normal blood pressure group. Body height, weight, waist and hip circumference, and biochemical data were measured. Homeostasis model assessment of insulin resistance (HOMA-IR), insulin sensitivity index (ISI)-composite, and first-phase (1 PH) Stumvoll index were calculated. Results Waist circumference, total cholesterol, triglyceride, low-density lipoprotein cholesterol, HOMA-IR were significantly higher and IPH Stumvoll index and ISI-composite were significantly lower in high-normal blood pressure group than in normal blood pressure group (P < 0.05). Systolic blood pressure (SBP) was positively correlated with HOMA-IR (r = 0.122) and negatively correlated with 1PH Stumvoll index (r = -0. 159) and ISI-composite (r = -0.131) (P < 0.05). SBP and triglyceride were independent factors for IPH Stumvoll index.
  
  
  CONCLUSIONS
  Insulin resistance and islet dysfunction may exist in subjects with high-normal blood pressure.
authors.affiliation: Department of Endocrinology, Key Laboratory of Endocrinology Ministry of Health, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
authors.forename: Ling-Ling
authors.initials: LL
authors.lastname: Xu
authors.forename: Hong-Ding
authors.initials: HD
authors.lastname: Xiang
authors.forename: Li-Hong
authors.initials: LH
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.forename: Jing-Hui
authors.initials: JH
authors.lastname: Fang
mesh_terms: D001794:Blood Pressure; D015992:Body Mass Index; D001835:Body Weight; D002784:Cholesterol / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D007333:Insulin Resistance / Q000502:physiology*; D014280:Triglycerides / Q000097:blood; D055105:Waist Circumference
chemical_list: D008078:Cholesterol, LDL; D014280:Triglycerides; D002784:Cholesterol