Protumor vs antitumor functions of IL-17.
Inflammation appears to be a necessity for both metastasis and elimination of tumor cells. IL-17, a proinflammatory cytokine produced by Th17 cells, contributes to both the processes by playing a dual role in the antitumor immunity. On one hand, IL-17 promotes an antitumor cytotoxic T cell response leading to tumor regression. On the other hand, by facilitating angiogenesis and egress of tumor cells from the primary focus, IL-17 promotes tumor growth. Thus, the therapeutic application that uses IL-17 needs to be refined by minimizing its protumor functions.
Murugaiyan
Gopal
G
Center for Neurologic Diseases, Brigham and Women's Hopsital and Harvard Medical School, Boston, MA 02120, USA.
Saha
Bhaskar
B
D000818:Animals; D006801:Humans; D020381:Interleukin-17 / Q000096:biosynthesis / Q000378:metabolism / Q000502:physiology*; D009369:Neoplasms / Q000276:immunology* / Q000378:metabolism / Q000517:prevention & control*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology / Q000378:metabolism
D020381:Interleukin-17