Case control study of gastrointestinal complications after cardiopulmonary bypass heart surgery.
BACKGROUND
Gastrointestinal complications (GIC) after cardiopulmonary bypass (CPB) surgery are rare, but, nevertheless, extremely dangerous.The identification of risks for GIC may be helpful in planning appropriate perioperative management strategies. The aim of the present study was to analyze perioperative factors of GIC in patients undergoing CPB surgery.


METHODS
We retrospectively analysed 206 patients who underwent GIC after cardiopulmonary bypass surgery from 2000 to 2007 and compared them with 206 matched control patients (matched for surgery, temperature, hemodilution and date). Univariate analysis and multiple logistic regression analysis were performed on 12 risk factors.


RESULTS
Sex and types of cardioplegia perfusate did not significantly influence the GIC after CPB surgery. Multiple logistic regression revealed that CPB time, preoperative serum creatinine (PSC) > or = 179 mg/dL, emergency surgery, perfusion pressure < or =40 mmHg, low cardiac output syndrome (LCOS), age > or = 61, mechanical ventilation > or =96 h, New York Heart Association (NYHA) class III and IV were predictors of the occurrence of GIC after CPB surgery. Perfusion pressure and aprotinin administration were protective factors.


CONCLUSIONS
Gastrointestinal complications after CPB surgery could be predictive in the presence of the above risk factors. This study suggests that GIC can be reduced by maintenance of higher perfusion pressure and shortening the time on CPB and ventilation.
Zhang
Guowei
G
Department of Cardio-Vascular Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China. godway@tom.com
Wu
Naishi
N
Liu
Hongyu
H
Lv
Hang
H
Yao
Zhifa
Z
Li
Junquan
J
D000328:Adult; D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D016022:Case-Control Studies; D005260:Female; D005767:Gastrointestinal Diseases / Q000209:etiology* / Q000473:pathology; D041981:Gastrointestinal Tract / Q000473:pathology*; D006438:Hemodilution; D006801:Humans; D008297:Male; D008875:Middle Aged; D019990:Perioperative Care; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome; D055815:Young Adult