Variation of fasting serum C-peptide level after admission in Japanese patients with type 2 diabetes mellitus.
BACKGROUND
The aim of this study was to evaluate the variation of fasting serum C-peptide (S-CPR) levels, as a marker for endogenous insulin secretion after admission in Japanese patients with type 2 diabetes mellitus (T2DM).


METHODS
S-CPR levels together with other metabolic factors were measured in 234 T2DM patients twice: at the beginning and at the end of admission for the control of blood sugar levels. As a result, patients were classified into two groups according to their changes of S-CPR (DeltaS-CPR), which consisted of patients whose S-CPR levels had decreased (group D) and increased (group I) after admission.


RESULTS
Patients allocated to group I showed younger age, shorter duration of diabetes, and lower basal S-CPR level compared to group D. Conversely, patients in group D showed higher levels of high-sensitivity C-reactive protein (HS-CRP) and brachial-ankle pulse wave velocity compared to group I, suggesting patients in this group are prone to atherosclerosis. DeltaS-CPR was positively correlated with the change of body mass index, waist circumference, and triglycerides in group D. On the other hand, DeltaS-CPR was negatively correlated with the change of HS-CRP in group I, indicating residual beta-cell function could be recovered by the amelioration of inflammatory status in pancreatic islets.


CONCLUSIONS
It is plausible that Japanese T2DM patients could be classified according to the variation of S-CPR after admission. Evaluation of basal and the variation of S-CPR could provide advantageous information for the management of diabetes mellitus or related disorders.
Tajiri
Yuji
Y
Endocrinology and Metabolism Division, Kurume University School of Medicine, Kurume, Japan. tajiriy@med.kurume-u.ac.jp
Kimura
Mikako
M
Mimura
Kazuo
K
Umeda
Fumio
F
D000368:Aged; D000375:Aging; D000428:Alcohol Drinking / Q000453:epidemiology; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D002096:C-Peptide / Q000097:blood*; D048909:Diabetes Complications / Q000453:epidemiology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000145:classification; D003927:Diet, Diabetic; D004038:Diet, Reducing; D050171:Dyslipidemias / Q000453:epidemiology; D015444:Exercise; D005215:Fasting / Q000097:blood; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D007564:Japan; D008297:Male; D008875:Middle Aged; D010343:Patient Admission; D010351:Patient Discharge; D013223:Statistics as Topic
D015415:Biomarkers; D001786:Blood Glucose; D002096:C-Peptide