Nucleoside modification with boron clusters and their metal complexes.
General methods for the synthesis of nucleosides modified with borane clusters and metallacarborane complexes are presented. These include: (1) the click chemistry approach based on Huisgen 1,3-dipolar cycloaddition and (2) tethering of the metallacarborane group to the aglycone of a nucleoside via a dioxane ring opening in oxonium metallacarborane derivatives. The proposed methodologies broaden the availability of nucleoside-borane cluster conjugates and open up new areas for their applications.
Wojtczak
Blazej A
BA
Institute for Medical Biology, Polish Academy of Sciences, Laboratory of Molecular Virology and Biological Chemistry, Lodz, Poland.
Olejniczak
Agnieszka B
AB
Lesnikowski
Zbigniew J
ZJ
D001896:Boron Compounds / Q000737:chemistry* / Q000378:metabolism; D002621:Chemistry / Q000379:methods*; D009705:Nucleosides / Q000138:chemical synthesis*
D001896:Boron Compounds; D009705:Nucleosides