Clinical and resistance consequences of misquantification of plasma and cerebrospinal fluid human immunodeficiency virus type 1 (HIV-1) RNA in samples from an HIV-1 subtype G-infected patient.
Human immunodeficiency virus (HIV) load is the main marker used to monitor antiviral treatment efficacy and resistance. We report a case of underquantification of HIV type 1 (HIV-1) RNA in plasma and cerebrospinal fluid from an HIV-1 subtype G-infected woman, leading to delayed diagnosis of HIV encephalitis and to the emergence of drug resistance.
Delaugerre
Constance
C
Department of Virology, Saint-Louis Hospital, 1 avenue Claude Vellefaux, 75010 Paris, France. constance.delaugerre@sls.aphp.fr
Denis
Blandine
B
Peytavin
Gilles
G
Palmer
Pierre
P
Mourez
Thomas
T
Le Goff
Jerôme
J
Molina
Jean-Michel
JM
Simon
François
F
D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D002555:Cerebrospinal Fluid / Q000821:virology*; D003951:Diagnostic Errors; D024882:Drug Resistance, Viral; D018792:Encephalitis, Viral; D005260:Female; D015658:HIV Infections / Q000821:virology*; D015497:HIV-1 / Q000302:isolation & purification*; D006801:Humans; D010949:Plasma / Q000821:virology*; D012367:RNA, Viral / Q000097:blood / Q000134:cerebrospinal fluid; D019562:Viral Load
D019380:Anti-HIV Agents; D012367:RNA, Viral