title: Analysis of Y-chromosomal short tandem repeat (STR) polymorphism in an Iranian Sadat population.
abstract: The molecular genotyping of individuals and reconstruction of kinship through short and highly polymorphic DNA markers, so called short tandem repeats (STR), has become one of the important and efficient methods in anthropology studies and forensic science. Although many populations have been analyzed, no study has yet been carried out on Sadat populations who are putative descendents of Prophet Mohammad (peace be upon him). Polymorphisms of 6 Y-STR loci (DYS19, DYS385a/b, DYS389II, DYS390, DYS392, and DYS393) have been studied in an unrelated population of Sadat males. The aim of this study was to find possible similarities within Sadat males, resided in Iran. Among Sadat, DYS385b was proved to be the most polymorphic (GD = 0.8588), and DYS392 showed the lowest polymorphism (GD = 0.3527). In 50 samples, 45 different haplotypes were found, of which 39 haplotypes were unique. In the study, three samples had multi-allelic patterns. Haplotype diversity, in regard to these 7 markers was 0.9942.
authors.affiliation: Department of Cellular and Molecular Biology, School of Biology, College of Sciences, University of Tehran, Tehran 14155-6455, Iran.
authors.forename: M R
authors.initials: MR
authors.lastname: Rafiee
authors.forename: A
authors.initials: A
authors.lastname: Sokhansanj
authors.forename: M A
authors.initials: MA
authors.lastname: Naghizadeh
authors.forename: A
authors.initials: A
authors.lastname: Farazmand
mesh_terms: D041322:Chromosomes, Human, Y / Q000235:genetics*; D005819:Genetic Markers; D005828:Genetics, Population; D006801:Humans; D007492:Iran / Q000208:ethnology; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics*; D011110:Polymorphism, Genetic; D040641:Quantitative Trait Loci / Q000235:genetics*
chemical_list: D005819:Genetic Markers