title: Micro- and nanotechnologies for intelligent and responsive biomaterial-based medical systems.
abstract: Advances in medical treatments of a wide variety of pathophysiological conditions require the development of better therapeutic agents, as well as a combination of the required therapeutic agents with device-integrated biomaterials that can serve as sensors and carriers. Combination of micro- and nano-fabricated systems with intelligent biomaterials that have the ability to sense and respond is a promising avenue for the development of better diagnostic and therapeutic medical systems. Micro- and nano-electromechanical systems (MEMs and NEMs) are now becoming a family of potentially powerful new technologies for drug delivery, diagnostic tools, and tissue engineering. Improvements in micro- and nano-fabrication technologies have enhanced the ability to create better performing therapeutic systems for numerous pathophysiological applications. More importantly, MEMS- and NEMS-based tissue regeneration scaffolds, biosensors, and drug delivery devices provide new opportunities to mimic the natural intelligence and response of biological systems.
authors.affiliation: Department of Biomedical Engineering, University of Texas at Austin, Austin, TX 78712-0238, USA.
authors.forename: Mary
authors.initials: M
authors.lastname: Caldorera-Moore
authors.forename: Nicholas A
authors.initials: NA
authors.lastname: Peppas
mesh_terms: D001672:Biocompatible Materials / Q000627:therapeutic use*; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D008956:Models, Chemical; D036103:Nanotechnology / Q000379:methods*; D013678:Technology, Pharmaceutical / Q000379:methods*; D023822:Tissue Engineering
chemical_list: D001672:Biocompatible Materials