title: Recent patents on the Pichia pastoris expression system: expanding the toolbox for recombinant protein production.
abstract: Pichia pastoris is a widely used host system for heterologous protein expression both for basic research and industrial production purposes. Recent developments expanding the P. pastoris protein expression toolbox reflect the increasing interest in the application of yeast expression systems for protein-based pharmaceutical products, as an alternative to Escherichia coli and mammalian cell factories. The commonly used expression system for P. pastoris and the recent patents relevant to the P. pastoris genetic toolbox for recombinant protein production are reviewed.
authors.affiliation: Bioingenium s.l., Barcelona Science Park, Helix Building, Baldiri Reixac 15, 08028 Barcelona, Spain.
authors.forename: Monika
authors.initials: M
authors.lastname: Bollok
authors.forename: David
authors.initials: D
authors.lastname: Resina
authors.forename: Francisco
authors.initials: F
authors.lastname: Valero
authors.forename: Pau
authors.initials: P
authors.lastname: Ferrer
mesh_terms: D015870:Gene Expression; D005818:Genetic Engineering / Q000379:methods*; D010330:Patents as Topic; D010843:Pichia / Q000166:cytology / Q000235:genetics* / Q000254:growth & development; D011994:Recombinant Proteins / Q000096:biosynthesis*; D012045:Regulatory Sequences, Nucleic Acid / Q000235:genetics
chemical_list: D011994:Recombinant Proteins