title: Molecular epidemiology of Mycobacterium tuberculosis in a South African community with high HIV prevalence.
abstract: To explore the relationship between human immunodeficiency virus (HIV) and Mycobacterium tuberculosis genotypes, we performed IS6110-based restriction fragment-length polymorphism analysis on M. tuberculosis culture specimens from patients with smear-positive tuberculosis in a periurban community in South Africa from 2001 through 2005. Among 151 isolates, 95 strains were identified within 26 families, with 54% clustering. HIV status was associated with W-Beijing strains (P = .009) but not with clustering per se. The high frequency of clustering suggests ongoing transmission in both HIV-negative and HIV-positive individuals in this community. The strong association between W-Beijing and HIV infection may have important implications for tuberculosis control.
authors.affiliation: Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, Cape Town, South Africa. keren.middelkoop@hiv-research.org.za
authors.forename: Keren
authors.initials: K
authors.lastname: Middelkoop
authors.forename: Linda-Gail
authors.initials: LG
authors.lastname: Bekker
authors.forename: Barun
authors.initials: B
authors.lastname: Mathema
authors.forename: Elena
authors.initials: E
authors.lastname: Shashkina
authors.forename: Natalia
authors.initials: N
authors.lastname: Kurepina
authors.forename: Andrew
authors.initials: A
authors.lastname: Whitelaw
authors.forename: Dorothy
authors.initials: D
authors.lastname: Fallows
authors.forename: Carl
authors.initials: C
authors.lastname: Morrow
authors.forename: Barry
authors.initials: B
authors.lastname: Kreiswirth
authors.forename: Gilla
authors.initials: G
authors.lastname: Kaplan
authors.forename: Robin
authors.initials: R
authors.lastname: Wood
mesh_terms: D005190:Family; D005838:Genotype; D015658:HIV Infections / Q000453:epidemiology*; D006801:Humans; D017720:Molecular Epidemiology; D009169:Mycobacterium tuberculosis / Q000235:genetics*; D010802:Phylogeny; D012150:Polymorphism, Restriction Fragment Length; D015995:Prevalence; D013019:South Africa / Q000453:epidemiology; D014376:Tuberculosis / Q000453:epidemiology* / Q000382:microbiology* / Q000517:prevention & control