title: Intercepting the synthesis of triazine dendrimers with nucleophilic pharmacophores: a general strategy toward drug delivery vehicles.
abstract: The camptothecin ester of isonipecotic acid is installed on a triazine dendrimer intermediate obtained through an iterative, scalable route to ultimately yield cationic and PEGylated targets with activities in cell culture comparable to free drug.
authors.affiliation: Department of Chemistry, Texas A&M University, College Station, TX 77843, USA.
authors.forename: Vincent J
authors.initials: VJ
authors.lastname: Venditto
authors.forename: Kimberly
authors.initials: K
authors.lastname: Allred
authors.forename: Clinton D
authors.initials: CD
authors.lastname: Allred
authors.forename: Eric E
authors.initials: EE
authors.lastname: Simanek
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D002166:Camptothecin / Q000138:chemical synthesis / Q000737:chemistry / Q000633:toxicity; D045744:Cell Line, Tumor; D050091:Dendrimers / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000737:chemistry; D006801:Humans; D007540:Isonipecotic Acids / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry; D014227:Triazines / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D050091:Dendrimers; D004337:Drug Carriers; D007540:Isonipecotic Acids; D014227:Triazines; D011092:Polyethylene Glycols; D002166:Camptothecin