title: Neutralizing antibody responses in preconditioned calves following vaccination for respiratory viruses.
abstract: Calf preconditioning programs that include vaccinations against common respiratory pathogens are beneficial; however, optimal vaccination protocols have not been determined. In the study described here, calves were placed in a preconditioning program and assigned to one of nine vaccine regimens, each consisting of some combinations of killed or modified-live virus vaccines against bovine herpesvirus-1 (BHV-1), bovine viral diarrhea virus (BVDV), parainfluenza-3 (PI-3) virus, and bovine respiratory syncytial virus (BRSV). Serum virus-neutralization antibody titers were measured at four time points. At the end of the study, all vaccinated calves had higher antibody titers to BVDV, BHV-1, and PI-3 but not BRSV. Calves on a vaccine program that included at least one dose of modified-live virus vaccine had higher virus-neutralizing antibody titers against BVDV than did calves receiving only killed vaccines. Calves on a program with a combination of modified-live and killed virus vaccines had higher virus-neutralizing antibody titers to BHV-1 than did calves receiving only killed or only modified-live virus vaccine. Preconditioning programs that include vaccinations should incorporate modified-live vaccines to maximize virus-neutralizing antibodies in serum.
authors.affiliation: Michigan State University, College of Veterinary Medicine, Department of Large Animal Clinical Sciences, East Lansing, MI 48824, USA.
authors.forename: Daniel L
authors.initials: DL
authors.lastname: Grooms
authors.forename: Paul
authors.initials: P
authors.lastname: Coe
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood*; D048090:Bovine Respiratory Disease Complex; D002417:Cattle; D001908:Diarrhea Viruses, Bovine Viral / Q000276:immunology; D005260:Female; D007242:Herpesvirus 1, Bovine / Q000276:immunology; D008297:Male; D029101:Parainfluenza Virus 3, Bovine / Q000276:immunology; D018112:Respiratory Syncytial Virus, Bovine / Q000276:immunology; D015164:Vaccines, Inactivated / Q000276:immunology; D014765:Viral Vaccines / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D015164:Vaccines, Inactivated; D014765:Viral Vaccines