TAAR 6 and HSP-70 variations associated with bipolar disorder.
We report on the impact of a set of variations located in the HSP-70 (heat shock protein 70) and TAAR6 (trace amine associated receptors 6 gene) in a sample of bipolar patients. Holding a diagnosis of BPD was the first outcome measure. Response to pharmacotreatment in bipolar patients was the secondary outcome measure. One hundred seventy-one bipolar patients and 288 controls were enrolled for the study. Patients were administered HAM-D, YMRS and CGI at baseline and discharge by independent psychiatrists blind to genotypes. As a result, homozygosis at rs2075799 (HSP-70) was found to be more represented in controls than in cases (p=0.000009). The investigated variations did not show impact on treatment outcome. This study provides preliminary evidence that HSP-70 may play a role in the disrupted mechanisms that lead to BPD. Further confirmatory analyses in this direction are mandatory.
Pae
Chi-Un
CU
Department of Psychiatry, The Catholic University of Korea College of Medicine, Republic of Korea. pae@catholic.ac.kr
Drago
Antonio
A
Mandelli
Laura
L
De Ronchi
Diana
D
Serretti
Alessandro
A
D000328:Adult; D001714:Bipolar Disorder / Q000453:epidemiology* / Q000235:genetics*; D018797:Cell Cycle Proteins / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000453:epidemiology* / Q000235:genetics*; D014644:Genetic Variation / Q000235:genetics; D018840:HSP70 Heat-Shock Proteins / Q000235:genetics*; D006579:Heterozygote; D006801:Humans; D015994:Incidence; D007723:Korea / Q000453:epidemiology; D008297:Male; D009687:Nuclear Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D043562:Receptors, G-Protein-Coupled; D018570:Risk Assessment; D012307:Risk Factors; D000095383:Trace Amine-Associated Receptors
D018797:Cell Cycle Proteins; D018840:HSP70 Heat-Shock Proteins; D009687:Nuclear Proteins; D043562:Receptors, G-Protein-Coupled; C493988:TAAR6 protein, human; D000095383:Trace Amine-Associated Receptors