Synthesis of phthalocyanines-ALA conjugates: water-soluble compounds with low aggregation.
Syntheses of two water-soluble phthalocyanines (Pc) containing 5-aminolevulinic acid (ALA) linked to the core structure are described. These compounds were prepared by using original functionalizations, and they present remarkable structural and photophysical features, indicating that they could be applied to photodynamic therapy (PDT).
de Oliveira
Kleber T
KT
Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Av. Bandeirantes 3900, 14040-901, Ribeirão Preto-SP, Brazil. kleber.oliveira@ufabc.edu.br
de Assis
Francisco F
FF
Ribeiro
Anderson O
AO
Neri
Claudio R
CR
Fernandes
Adjaci U
AU
Baptista
Mauricio S
MS
Lopes
Norberto P
NP
Serra
Osvaldo A
OA
Iamamoto
Yassuko
Y
D000622:Aminolevulinic Acid / Q000138:chemical synthesis* / Q000737:chemistry; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D054833:Isoindoles; D015394:Molecular Structure; D012995:Solubility; D014867:Water / Q000737:chemistry*
D007211:Indoles; D054833:Isoindoles; D014867:Water; D000622:Aminolevulinic Acid; C013647:phthalocyanine