[Differential expression of guanylin in colorectal cancer].
OBJECTIVE
To investigate the expression of guanylin in colorectal cancer.


METHODS
The expression of guanylin was examined by RT-PCR and semiquantitative analysis in 20 cases of colorectal cancer, and its relationship with clinical characteristics was analyzed.


RESULTS
The positive expression of guanylin in normal tissue (80%, 16/20) was significantly higher than that in tumor tissue (35%, 7/20) (P<0.01). The same result was found in the semiquantitative analysis of 14 cases with differential expression. Differential expression of guanylin in colorectal cancer was associate with TNM stage (P<0.05), not with sex, Borrmann type and degree of differentiation (all P>0.05).


CONCLUSIONS
There is differential expression of guanylin in colorectal cancer, and this kind of differential expression is associated with tumor TNM stage.
Chen
Yin-bo
YB
Department of Colorectal Oncology, Zhejiang Cancer Hospital, Hangzhou, China.
Zhu
Yu-ping
YP
Feng
Hai-yang
HY
Liu
Yong
Y
Qian
Jun
J
Fan
Yong-tian
YT
Li
De-chuan
DC
D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D005768:Gastrointestinal Hormones / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D045265:Natriuretic Peptides / Q000378:metabolism*; D009367:Neoplasm Staging
D005768:Gastrointestinal Hormones; D045265:Natriuretic Peptides; C072685:guanylin