title: Acute myocardial infarction in a patient with hemophilia A and factor V Leiden mutation.
abstract: Factor VIII:C, epsilon amino-caproic acid or tranexamic acid are prophylactic agents used in preventing hemorrhage pre-operatively in patients with hemophilia A. Although hemophilia A seems to be a factor that avoids the development of acute myocardial infarction (AMI) as it tends to be associated with increased bleeding, it should be kept in mind that prothrombotic agents used pre-operatively for prophylaxis may increase the risk for AMI in the presence of the factor V Leiden mutation. In this report, we discuss the development of AMI following the use of recombinant factor VIII and tranexamic acid for prophylaxis in a patient with known hemophilia before a tooth extraction in conjunction with the relevant literature.
authors.affiliation: 2nd Clinic for Internal Diseases, Okmeydani Education and Research Hospital, Istanbul, Turkey. meralgunaldi@hotmail.com
authors.forename: Meral
authors.initials: M
authors.lastname: Günaldi
authors.forename: Ayşen
authors.initials: A
authors.lastname: Helvaci
authors.forename: Naciye Demirel
authors.initials: ND
authors.lastname: Yildirim
authors.forename: Muharrem
authors.initials: M
authors.lastname: Kiskaç
authors.forename: Reyhan Diz
authors.initials: RD
authors.lastname: Küçükkaya
mesh_terms: D015906:Angioplasty, Balloon, Coronary / Q000295:instrumentation; D000933:Antifibrinolytic Agents / Q000009:adverse effects*; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D003029:Coagulants / Q000009:adverse effects*; D017023:Coronary Angiography; D023921:Coronary Stenosis / Q000150:complications / Q000175:diagnosis / Q000628:therapy; D005165:Factor V; D005169:Factor VIII / Q000009:adverse effects*; D006467:Hemophilia A / Q000150:complications / Q000188:drug therapy* / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D009203:Myocardial Infarction / Q000139:chemically induced / Q000175:diagnosis / Q000209:etiology* / Q000235:genetics / Q000628:therapy; D011994:Recombinant Proteins / Q000009:adverse effects; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D015607:Stents; D014081:Tooth Extraction / Q000009:adverse effects*; D014148:Tranexamic Acid / Q000009:adverse effects*
chemical_list: D000933:Antifibrinolytic Agents; D003029:Coagulants; D011994:Recombinant Proteins; C095381:factor V Leiden; D014148:Tranexamic Acid; C078147:F8 protein, human; D005165:Factor V; D005169:Factor VIII