Utility of an interferon-gamma release assay for latent tuberculosis diagnosis in a case of bullous pemphigoid.
BACKGROUND
With increasing use of immunosuppressive therapy, including tumor necrosis factor alpha inhibitors, there is concern about infectious complications, including reactivation of latent Mycobacterium tuberculosis infection. Routine testing prior to administration of systemic immunosuppression includes the tuberculin skin test, which lacks sensitivity and specificity and may be difficult to interpret in the presence of extensive cutaneous disease. Treatment of individuals with latent tuberculosis infection is recommended when immunosuppressive medications are to be employed.


METHODS
We report a case in which a diagnosis of latent tuberculosis infection in a patient with extensive bullous pemphigoid was clarified by the use of an interferon-gamma release assay after equivocal tuberculin skin test results.


CONCLUSIONS
Interferon-gamma release assays are useful adjuncts to the tuberculin skin test in the diagnosis of latent tuberculosis infection in the setting of extensive cutaneous disease.
Goodfellow
Alfred
A
Department of Dermatology; Department of Infectious Disease, Saint John Regional Hospital, Saint John, NB. alfred.goodfellow@unb.ca
Keeling
Douglas N
DN
Hayes
Robert C
RC
Webster
Duncan
D
D000369:Aged, 80 and over; D001681:Biological Assay / Q000379:methods*; D003937:Diagnosis, Differential; D006801:Humans; D007371:Interferon-gamma / Q000032:analysis*; D055985:Latent Tuberculosis / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D008297:Male; D010391:Pemphigoid, Bullous / Q000150:complications*
D007371:Interferon-gamma