title: Skin immune sentinels in health and disease.
abstract: Human skin and its immune cells provide essential protection of the human body from injury and infection. Recent studies reinforce the importance of keratinocytes as sensors of danger through alert systems such as the inflammasome. In addition, newly identified CD103(+) dendritic cells are strategically positioned for cross-presentation of skin-tropic pathogens and accumulating data highlight a key role of tissue-resident rather than circulating T cells in skin homeostasis and pathology. This Review focuses on recent progress in dissecting the functional role of skin immune cells in skin disease.
authors.affiliation: St. John's Institute of Dermatology, King's College London, UK. frank.nestle@kcl.ac.uk
authors.forename: Frank O
authors.initials: FO
authors.lastname: Nestle
authors.forename: Paola
authors.initials: P
authors.lastname: Di Meglio
authors.forename: Jian-Zhong
authors.initials: JZ
authors.lastname: Qin
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Nickoloff
mesh_terms: D000818:Animals; D003713:Dendritic Cells / Q000276:immunology* / Q000378:metabolism; D003872:Dermatitis / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D007113:Immunity, Innate; D015603:Keratinocytes / Q000276:immunology* / Q000378:metabolism; D008264:Macrophages / Q000276:immunology* / Q000378:metabolism; D011565:Psoriasis / Q000276:immunology / Q000378:metabolism; D012867:Skin / Q000033:anatomy & histology / Q000276:immunology* / Q000378:metabolism; D016176:T-Lymphocyte Subsets / Q000276:immunology* / Q000378:metabolism