title: Pure erythroid leukemia with hemophagocytosis.
abstract: A 53-year-old man was admitted with pancytopenia, fever and splenomegaly. Biochemistry showed increased ferritin levels. Bone marrow examination revealed increased erythrocytic precursors (94.9%) and active hemophagocytosis. Pure erythroid leukemia with hemophagocytic syndrome (HPS) was diagnosed. Induction chemotherapy comprising idarubicin and cytarabine was administered and steroid pulse therapy was added. Complete remission was attained, and HPS also improved. However, leukemia relapsed during chemotherapy and the patient died. This is the first report of pure erythroid leukemia complicated with HPS.
authors.affiliation: Department of Internal Medicine, Kisogawa Municipal Hospital, Ichinomiya, Japan.
authors.forename: Junichi
authors.initials: J
authors.lastname: Kitagawa
authors.forename: Takeshi
authors.initials: T
authors.lastname: Hara
authors.forename: Hisashi
authors.initials: H
authors.lastname: Tsurumi
authors.forename: Masami
authors.initials: M
authors.lastname: Oyama
authors.forename: Hisataka
authors.initials: H
authors.lastname: Moriwaki
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D001853:Bone Marrow / Q000473:pathology; D003561:Cytarabine / Q000627:therapeutic use; D017809:Fatal Outcome; D006801:Humans; D015255:Idarubicin / Q000627:therapeutic use; D004915:Leukemia, Erythroblastic, Acute / Q000150:complications* / Q000188:drug therapy / Q000235:genetics / Q000473:pathology; D051359:Lymphohistiocytosis, Hemophagocytic / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged
chemical_list: D000970:Antineoplastic Agents; D003561:Cytarabine; D008775:Methylprednisolone; D015255:Idarubicin