Animal models reveal role for tau phosphorylation in human disease.
Many proteins that are implicated in human disease are posttranslationally modified. This includes the microtubule-associated protein tau that is deposited in a hyperphosphorylated form in brains of Alzheimer's disease patients. The focus of this review article is on the physiological and pathological phosphorylation of tau; the relevance of aberrant phosphorylation for disease; the role of kinases and phosphatases in this process; its modeling in transgenic mice, flies, and worms; and implications of phosphorylation for therapeutic intervention.
Götz
Jürgen
J
Alzheimer's and Parkinson's Disease Laboratory, Brain and Mind Research Institute, University of Sydney, 100 Mallett Street, Camperdown, New South Wales 2050, Australia. jgoetz@med.usyd.edu.au
Gladbach
Amadeus
A
Pennanen
Luis
L
van Eersel
Janet
J
Schild
Andreas
A
David
Della
D
Ittner
Lars M
LM
D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D010766:Phosphorylation; D016875:tau Proteins / Q000502:physiology*
D016875:tau Proteins