Synthesis and anti-HCV activity of 2',5'-deoxy-5'-phenacyladenosine analogs.
Several nucleoside analogs containing a methylene group instead of a 5'-O atom were synthesized to study the effect of the 5'-modification of nucleoside analogs on their anti-HCV activity. Among the analogs, a 5'-phenacyl analog exhibited good anti-HCV activity with an EC(50) of 15.1 muM. This compound is hypothesized to function via a novel type of mechanism that does not involve the conventional 5'-O-triphosphorylation process.
Ikejiri
Masahiro
M
Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University, Sanuki, Kagawa 769-2193, Japan. ikejim@osaka-ohtani.ac.jp
Ohshima
Takayuki
T
Fukushima
Akemi
A
Shimotohno
Kunitada
K
Maruyama
Tokumi
T
D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D003853:Deoxyribonucleosides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D016174:Hepacivirus / Q000187:drug effects*
D000998:Antiviral Agents; D003853:Deoxyribonucleosides; D000241:Adenosine