title: Arachidonic acid supplementation decreases P300 latency and increases P300 amplitude of event-related potentials in healthy elderly men.
abstract: In the present study, we examined the effects of arachidonic acid (ARA) on age-related event-related potential (ERP) changes in 25 healthy elderly men. This study was performed using a double-blind crossover design. The subjects were administered 600 mg/day of ARA-enriched triglyceride (SUNTGA40S; containing 240 mg ARA) in capsules or the same amount of olive oil in capsules as an inactive placebo for 1 month. ERPs were measured before capsule administration and after 1 month of administration, and P300 latency and amplitude were also measured. In subjects administered 240 mg/day ARA, P300 latency was significantly shorter, and P300 amplitude was significantly higher than in those administered olive oil capsules, and they exhibited a significant increase in ARA content in serum phospholipids. These findings suggest that supplementation of ARA can improve cognitive function in healthy elderly men.
authors.affiliation: Institute for Health Care Science, Suntory Ltd., Osaka, Japan. Yoshiyuki_Ishikura@suntory.co.jp
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Ishikura
authors.forename: Gakuro
authors.initials: G
authors.lastname: Ikeda
authors.forename: Kengo
authors.initials: K
authors.lastname: Akimoto
authors.forename: Mie
authors.initials: M
authors.lastname: Hata
authors.forename: Aki
authors.initials: A
authors.lastname: Kusumoto
authors.forename: Ayako
authors.initials: A
authors.lastname: Kidokoro
authors.forename: Masanori
authors.initials: M
authors.lastname: Kontani
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kawashima
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Kiso
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Koga
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D016718:Arachidonic Acid / Q000008:administration & dosage* / Q000097:blood; D001921:Brain / Q000187:drug effects* / Q000502:physiology; D003071:Cognition / Q000187:drug effects* / Q000502:physiology; D018592:Cross-Over Studies; D019587:Dietary Supplements; D004311:Double-Blind Method; D004569:Electroencephalography; D018913:Event-Related Potentials, P300 / Q000187:drug effects*; D005227:Fatty Acids / Q000008:administration & dosage / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D018697:Nootropic Agents / Q000008:administration & dosage* / Q000097:blood; D013997:Time Factors
chemical_list: D005227:Fatty Acids; D018697:Nootropic Agents; D016718:Arachidonic Acid