Galectin-10, eosinophils, and celiac disease.
Celiac disease (CD) is a chronic intestinal disease caused by intolerance to dietary wheat gluten in genetically susceptible individuals. There are a number of important open questions that impede the full explanation of the pathogenesis of this disease. We analyzed protein expression pattern in gut biopsies of CD subjects. Patients were selected and grouped according to histological inflammatory degree. Groups consisted of nine individuals with CD: three patients had a Marsh 0, three a Marsh I-II, and three a Marsh III. All CD patients showed a human leukocyte antigen DQ2/8 variant. Controls were three individuals with an excluded CD diagnosis. For the first time, galectin-10 expression was found related to the histological grade (P = 0.0092) and with the number of eosinophils in the lesion (P = 0.0040). Results suggest galectin-10 is a novel marker for evaluating CD tissue damage and eosinophils as a possible target for therapeutic approaches. Moreover, our data provide insights into alterations associated with CD tissue damage and pathogenesis.
De Re
Valli
V
Experimental and Clinical Pharmacology Unit, Istituto Di Ricovero e Cura a Carattere Scientifico, Aviano, Italy. vdere@cro.it
Simula
Maria Paola
MP
Cannizzaro
Renato
R
Pavan
Alessandro
A
De Zorzi
Mari Angela
MA
Toffoli
Giuseppe
G
Canzonieri
Vincenzo
V
D002446:Celiac Disease / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism*; D015180:Electrophoresis, Gel, Two-Dimensional; D004804:Eosinophils / Q000473:pathology*; D037161:Galectins / Q000378:metabolism*; D014644:Genetic Variation; D006098:Granulocytes / Q000473:pathology; D006683:HLA-DQ Antigens / Q000235:genetics; D006801:Humans; D007958:Leukocyte Count; D016133:Polymerase Chain Reaction; D020543:Proteome / Q000378:metabolism; D040901:Proteomics / Q000379:methods; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
D037161:Galectins; D006683:HLA-DQ Antigens; D020543:Proteome