title: Increase of ejaculatory capacity by systemic administration of the oquichpatli (Senecio cardiophyllus) aqueous crude extract in male rats.
abstract: OBJECTIVE
  To analyse the pro-ejaculatory properties of the proverbial Mexican plant oquichpatli, Senecio cardiophyllus, in an animal model for the study of ejaculation in spinal and anaesthetised male rats.
  
  
  METHODS
  The aqueous crude extract of Senecio cardiophyllus (at 0.4, 1.2 and 4 mg/kg) was i.v. administered to (a) anaesthetised and spinalised male rats after spinal cord transection and (b) anaesthetised and spinalised male rats previous to the inhibition of ejaculation elicited by repeated urethral stimulation. The motor pattern of ejaculation and the development of its inhibition were analysed under the influence of the aqueous crude extract of Senecio cardiophyllus and compared to urethrally induced ejaculations.
  
  
  RESULTS
  Systemic administration of the Senecio cardiophyllus aqueous crude extract, at all tested doses, induced the ejaculatory response in male rats. This response was featured by a statistically significant augmented number of ejaculatory discharges when compared to control animals. Oquichpatli-induced ejaculatory responses included the expression of autonomic and motor components of ejaculation and the potent expulsion of urethral contents and seminal plugs. Administration of oquichpatli aqueous crude extract prevented the inhibition of ejaculation elicited by urethral stimulation by promoting a statistically significant increase in the expression of ejaculatory motor patterns.
  
  
  CONCLUSIONS
  Present findings show by the first time that the aqueous crude extract of Senecio cardiophyllus possesses the ability to increase the ejaculatory capacity in male rats.
authors.affiliation: Laboratory of Reproductive Behaviour, Veterinary Medical School, Autonomous University of Tlaxcala, P.C. 90000, Tlaxcala, Mexico. miguel_carro@hotmail.com
authors.forename: M
authors.initials: M
authors.lastname: Carro-Juárez
authors.forename: C
authors.initials: C
authors.lastname: Alcazar
authors.forename: E
authors.initials: E
authors.lastname: Ballesteros-Polvo
authors.forename: P
authors.initials: P
authors.lastname: Villalobos-Peñalosa
mesh_terms: D000818:Animals; D004542:Ejaculation / Q000187:drug effects*; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012674:Senecio / Q000737:chemistry*; D014867:Water
chemical_list: D010936:Plant Extracts; D014867:Water