title: Peruvian horse sickness virus and Yunnan orbivirus, isolated from vertebrates and mosquitoes in Peru and Australia.
abstract: During 1997, two new viruses were isolated from outbreaks of disease that occurred in horses, donkeys, cattle and sheep in Peru. Genome characterization showed that the virus isolated from horses (with neurological disorders, 78% fatality) belongs to a new species the Peruvian horse sickness virus (PHSV), within the genus Orbivirus, family Reoviridae. This represents the first isolation of PHSV, which was subsequently also isolated during 1999, from diseased horses in the Northern Territory of Australia (Elsey virus, ELSV). Serological and molecular studies showed that PHSV and ELSV are very similar in the serotype-determining protein (99%, same serotype). The second virus (Rioja virus, RIOV) was associated with neurological signs in donkeys, cattle, sheep and dogs and was shown to be a member of the species Yunnan orbivirus (YUOV). RIOV and YUOV are also almost identical (97% amino acid identity) in the serotype-determining protein. YUOV was originally isolated from mosquitoes in China.
authors.affiliation: Department of Vector Borne Diseases, Institute for Animal Health, Pirbright, Woking, Surrey, GU24 0NF, UK. houssam.attoui@bbsrc.ac.uk
authors.forename: Houssam
authors.initials: H
authors.lastname: Attoui
authors.forename: Maria Rosario
authors.initials: MR
authors.lastname: Mendez-Lopez
authors.forename: Shujing
authors.initials: S
authors.lastname: Rao
authors.forename: Ana
authors.initials: A
authors.lastname: Hurtado-Alendes
authors.forename: Frank
authors.initials: F
authors.lastname: Lizaraso-Caparo
authors.forename: Fauziah
authors.initials: F
authors.lastname: Mohd Jaafar
authors.forename: Alan R
authors.initials: AR
authors.lastname: Samuel
authors.forename: Mourad
authors.initials: M
authors.lastname: Belhouchet
authors.forename: Lindsay I
authors.initials: LI
authors.lastname: Pritchard
authors.forename: Lorna
authors.initials: L
authors.lastname: Melville
authors.forename: Richard P
authors.initials: RP
authors.lastname: Weir
authors.forename: Alex D
authors.initials: AD
authors.lastname: Hyatt
authors.forename: Steven S
authors.initials: SS
authors.lastname: Davis
authors.forename: Ross
authors.initials: R
authors.lastname: Lunt
authors.forename: Charles H
authors.initials: CH
authors.lastname: Calisher
authors.forename: Robert B
authors.initials: RB
authors.lastname: Tesh
authors.forename: Ricardo
authors.initials: R
authors.lastname: Fujita
authors.forename: Peter P C
authors.initials: PP
authors.lastname: Mertens
mesh_terms: D000818:Animals; D001483:Base Sequence; D002417:Cattle; D009033:Culicidae / Q000821:virology; D004196:Disease Outbreaks / Q000662:veterinary; D004285:Dogs; D018397:Equidae / Q000821:virology; D006734:Horse Diseases / Q000453:epidemiology / Q000821:virology*; D006736:Horses / Q000821:virology; D046529:Microscopy, Electron, Transmission; D017720:Molecular Epidemiology; D015876:Northern Territory; D018163:Orbivirus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification* / Q000472:pathogenicity; D010568:Peru; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics; D012088:Reoviridae Infections / Q000453:epidemiology / Q000662:veterinary* / Q000821:virology; D012703:Serotyping; D014764:Viral Proteins / Q000235:genetics
chemical_list: D012367:RNA, Viral; D014764:Viral Proteins