title: Aggressive subcutaneous panniculitis-like T-cell lymphoma with hemophagocytosis in two children (subcutaneous panniculitis-like T-cell lymphoma).
abstract: Subcutaneous panniculitis-like T-cell lymphoma is an uncommon form of cutaneous lymphoma in the pediatric population. It is characterized histologically by subcutaneous infiltration of pleomorphic cytotoxic T cells, mimicking a lobular panniculitis. Although usually described as having an indolent clinical course, the condition may be complicated by systemic involvement and hemophagocytic syndrome, resulting in a poorer prognosis. We present two pediatric patients with aggressive forms of subcutaneous panniculitis-like T-cell lymphoma complicated by hemophagocytic syndrome, and discuss the current literature.
authors.affiliation: Department of Dermatology, Changi General Hospital, Singapore. docmark@pacific.net.sg
authors.forename: Mark Jean-Aan
authors.initials: MJ
authors.lastname: Koh
authors.forename: Sapna P
authors.initials: SP
authors.lastname: Sadarangani
authors.forename: Yuin-Chew
authors.initials: YC
authors.lastname: Chan
authors.forename: Mei-Yoke
authors.initials: MY
authors.lastname: Chan
authors.forename: Ah-Moy
authors.initials: AM
authors.lastname: Tan
authors.forename: Suat-Hoon
authors.initials: SH
authors.lastname: Tan
authors.forename: Yong-Kwang
authors.initials: YK
authors.lastname: Tay
authors.forename: Siok-Bian
authors.initials: SB
authors.lastname: Ng
mesh_terms: D002648:Child; D005260:Female; D006801:Humans; D007223:Infant; D051359:Lymphohistiocytosis, Hemophagocytic / Q000209:etiology* / Q000473:pathology; D016399:Lymphoma, T-Cell / Q000150:complications* / Q000473:pathology; D008297:Male; D015434:Panniculitis / Q000209:etiology* / Q000473:pathology; D012720:Severity of Illness Index; D012878:Skin Neoplasms / Q000150:complications* / Q000473:pathology; D050151:Subcutaneous Fat / Q000473:pathology