title: Retrospective evaluation of CO(2) laser conization in pregnant women with carcinoma in situ or microinvasive carcinoma.
abstract: BACKGROUND
  We evaluated the safety and efficacy of CO(2) laser conization in pregnant women with cervical intraepithelial neoplasia 3/carcinoma in situ (CIN3/CIS) or microinvasive carcinoma (MIC).
  
  
  OBJECTIVE
  A total of 49 pregnant women with biopsy-proven CIN3/CIS (30 patients) or MIC (19 patients) were studied.
  
  
  METHODS
  Retrospective analysis based on clinical records.
  
  
  RESULTS
  Median age and median week of gestation were 31 years (range: 22-39) and 17 weeks (range: 7-33), respectively. The median length of cervix resected by conization, median duration of surgery and median blood loss were 14 mm (range: 5-23), 20 min (range: 7-35) and 78 ml (range: 10-797), respectively. One biopsy-proven CIN3/CIS patient was diagnosed with Federation of Gynecology and Obstetrics (FIGO) Ia2 and 3 biopsy-proven MIC patients were diagnosed with FIGO Ib1 based on conization specimens. A total of 35 patients could be followed until delivery, of which 27 (77.1%) patients delivered transvaginally. Although 8 patients (22.9%) had a cesarean section and 6 patients (17.1%) delivered preterm, no conization-related obstetric complications were observed.
  
  
  CONCLUSIONS
  Since it results in few obstetric complications, CO(2) laser conization within 20 mm of length can be considered a safe procedure for pregnant women.
authors.affiliation: Department of Obstetrics and Gynecology, Kinki University School of Medicine, Osaka, Japan.
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Tsuritani
authors.forename: Yoh
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Kotani
authors.forename: Taeko
authors.initials: T
authors.lastname: Kataoka
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Ueda
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hoshiai
mesh_terms: D000328:Adult; D001706:Biopsy; D002585:Cesarean Section / Q000706:statistics & numerical data; D019092:Conization / Q000009:adverse effects / Q000379:methods*; D005260:Female; D006801:Humans; D054020:Lasers, Gas; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000601:surgery*; D011256:Pregnancy Outcome; D047928:Premature Birth / Q000453:epidemiology; D012189:Retrospective Studies; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000601:surgery*; D002578:Uterine Cervical Dysplasia / Q000473:pathology / Q000601:surgery*