Fatal pneumonitis after treatment with docetaxel and trastuzumab.
Pneumonitis is a rare but serious complication of docetaxel treatment. We report a 63-year-old woman with locally advanced breast cancer who was treated with docetaxel and trastuzumab. After the first course she was admitted with febrile neutropenia that resolved rapidly. After the second course she was admitted again with fever and dyspnoea. Despite intensive treatment she died of respiratory failure three weeks later. Autopsy showed diffuse interstitial inflammation of both lungs consistent with drug-induced inflammation. Docetaxel treatment was the most likely cause. It is important to be aware of this toxicity, because the subtle warning signs can easily be mistaken for an opportunistic infection, and, if not recognised in time, the mortality rate is high.
Kuip
E
E
Department of Internal Medicine, Slingeland Hospital, Doetinchem, The Netherlands. evelienkuip@hotmail.com
Muller
E
E
D000911:Antibodies, Monoclonal / Q000009:adverse effects*; D061067:Antibodies, Monoclonal, Humanized; D000970:Antineoplastic Agents / Q000009:adverse effects*; D000077143:Docetaxel; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008875:Middle Aged; D011014:Pneumonia / Q000139:chemically induced* / Q000188:drug therapy; D012131:Respiratory Insufficiency / Q000139:chemically induced* / Q000209:etiology; D012307:Risk Factors; D043823:Taxoids / Q000009:adverse effects*; D000068878:Trastuzumab
D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D000970:Antineoplastic Agents; D043823:Taxoids; D000077143:Docetaxel; D000068878:Trastuzumab