title: Early growth and markers of cardiovascular risk in Keralan children in the Integrated Child Development Scheme.
abstract: OBJECTIVE
  Low birth weight is associated with increased lifelong morbidity. Kerala has a renowned, low-cost, maternal-child health system in which is couched universal access to the Integrated Child Development Scheme (ICDS), central to which is community-based maternal-infant nutritional supplementation. We assessed whether children in this environment showed enhanced birth weight and postnatal growth and whether the evolution of early markers of CVD was attenuated in comparison to contemporaries from other states.
  
  
  METHODS
  A part retrospective, part prospective cohort study in which children (n 286) born in 1998-2000 in Calicut were identified from Anganwadi records. They were traced at 6 years and underwent full anthropometry and blood pressure measurements at 6 and 8 years.
  
  
  RESULTS
  Mean birth weight (2.86 (SD 0.40) kg) was greater than in Indian contemporaries but consistently <-1 SD below the National Center for Health Statistics reference median throughout childhood. Birth weight significantly predicted body mass (BMI) at 8 years. Lower birth weight was strongly predictive of a higher waist:hip ratio (WHR) indicative of adverse central (coelomic) fat distribution (P < 0.01). Faster weight gain in infancy was weakly predictive of a lower WHR (P = 0.59), but faster late childhood growth at 6-8 years was non-significantly predictive of adverse WHR.
  
  
  CONCLUSIONS
  At 8 years of age, children in Calicut participating in the ICDS have greater birth weight and relative attenuation of the evolution of early CVD markers compared with children in apparently comparable states. The relative contributions of the ICDS and other factors inherent to Kerala cannot be inferred from the present study.
authors.affiliation: Salisbury District Hospital, Salisbury, Wiltshire, SP2 8BJ, UK. n_janbrown@yahoo.co.uk
authors.forename: Nick
authors.initials: N
authors.lastname: Brown
authors.forename: Chaniyil Krishnan
authors.initials: CK
authors.lastname: Sasidharan
authors.forename: David
authors.initials: D
authors.lastname: Fisher
mesh_terms: D015415:Biomarkers; D001724:Birth Weight / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000209:etiology*; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006130:Growth Disorders / Q000503:physiopathology; D006801:Humans; D007194:India; D007223:Infant; D007231:Infant, Newborn / Q000254:growth & development*; D008297:Male; D011446:Prospective Studies; D012189:Retrospective Studies; D012307:Risk Factors; D049629:Waist-Hip Ratio
chemical_list: D015415:Biomarkers