title: Canary Prostate Active Surveillance Study: design of a multi-institutional active surveillance cohort and biorepository.
abstract: Active surveillance is a management plan for localized prostate cancer that offers selective delayed intervention on indication of disease progression, allowing patients to delay or avoid treatment and associated side-effects. Outcomes from centers that promote active surveillance are favorable, with high rates of disease-specific survival. However, there remains a need for prognostic variables or biomarkers that distinguish with high specificity the aggressive cancers that progress on surveillance from the indolent cancers. The Canary Prostate Active Surveillance Study is a multicenter study and a biorepository that will discover and confirm biomarkers of aggressive disease as defined by histologic, prostate-specific antigen, or clinical criteria.
authors.affiliation: Department of Urology, University of Washington, Seattle, Washington 98195, USA.
authors.forename: Lisa F
authors.initials: LF
authors.lastname: Newcomb
authors.forename: James D
authors.initials: JD
authors.lastname: Brooks
authors.forename: Peter R
authors.initials: PR
authors.lastname: Carroll
authors.forename: Ziding
authors.initials: Z
authors.lastname: Feng
authors.forename: Martin E
authors.initials: ME
authors.lastname: Gleave
authors.forename: Peter S
authors.initials: PS
authors.lastname: Nelson
authors.forename: Ian M
authors.initials: IM
authors.lastname: Thompson
authors.forename: Daniel W
authors.initials: DW
authors.lastname: Lin
mesh_terms: D018070:Biological Specimen Banks; D015415:Biomarkers; D006801:Humans; D008297:Male; D015337:Multicenter Studies as Topic; D011159:Population Surveillance; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000097:blood / Q000628:therapy*
chemical_list: D015415:Biomarkers; D017430:Prostate-Specific Antigen