Palladium-catalyzed domino C,N-coupling/carbonylation/Suzuki coupling reaction: an efficient synthesis of 2-aroyl-/heteroaroylindoles.
A convenient one-pot synthesis of 2-aroylindoles using a domino palladium-catalyzed C,N-coupling/carbonylation/C,C-coupling sequence is described. The reaction involved easily prepared 2-gem-dibromovinylanilines and boronic acids under carbon monoxide. Optimized reaction conditions allowed the construction of a wide variety of highly functionalized 2-aroyl-/heteroaroylindoles in satisfactory yields.
Arthuis
Martin
M
Institut Curie, Centre de Recherche, 26 rue d'Ulm, Paris F-75248 cedex 05, France.
Pontikis
Renée
R
Florent
Jean-Claude
JC
D000814:Aniline Compounds / Q000737:chemistry; D001897:Boronic Acids / Q000737:chemistry; D002244:Carbon / Q000737:chemistry*; D002248:Carbon Monoxide / Q000737:chemistry; D002384:Catalysis; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry*; D009584:Nitrogen / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
D000814:Aniline Compounds; D001897:Boronic Acids; D007211:Indoles; D010165:Palladium; D002244:Carbon; D002248:Carbon Monoxide; D009584:Nitrogen; C023650:aniline