Mechanisms of cellular protrusions branch out.
F-BAR domains bind curved membranes and induce membrane invagination. In a recent Cell paper, Guerrier et al. describe an "inverse" F-BAR family member that induces outward curvature and filopodia in migrating neurons. These findings suggest that F-BAR domains are functionally diverse and regulate different types of membrane morphology.
Carlson
Benjamin
B
Department of Cell Biology, Duke University Medical School, Durham, NC 27710, USA.
Soderling
Scott H
SH
D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D002465:Cell Movement; D019281:Dimerization; D004705:Endocytosis; D005786:Gene Expression Regulation; D006801:Humans; D008954:Models, Biological; D009474:Neurons / Q000378:metabolism*; D017434:Protein Structure, Tertiary; D011554:Pseudopodia / Q000378:metabolism*