title: T lymphocyte responses to heterologous secondary dengue virus infections.
abstract: The available evidence suggests that plasma leakage in dengue hemorrhagic fever is caused by the action of circulating mediators on the vascular endothelium, and that the host immune response is a critical determinant of this response. We have been exploring the role of dengue virus-specific T lymphocytes in the immunopathogenesis of plasma leakage. Memory dengue virus-specific T cells induced during a primary dengue virus infection are reactivated by the heterologous viral serotype during a secondary infection to expand to high levels and produce a skewed cytokine profile. Investigations are underway to identify the immunologic profiles associated with increased or decreased risk for severe disease.
authors.affiliation: Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA. alan.rothman@umassmed.edu
authors.forename: Alan L
authors.initials: AL
authors.lastname: Rothman
mesh_terms: D000818:Animals; D002648:Child; D009033:Culicidae / Q000821:virology; D003715:Dengue / Q000276:immunology* / Q000635:transmission; D003716:Dengue Virus / Q000145:classification / Q000276:immunology; D004730:Endothelium, Vascular / Q000503:physiopathology / Q000821:virology; D006801:Humans; D007156:Immunologic Memory; D009000:Monocytes / Q000276:immunology; D010996:Pleural Effusion / Q000209:etiology / Q000821:virology; D012703:Serotyping; D019595:Severe Dengue / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D014766:Viremia / Q000276:immunology