9-(2-C-Cyano-2-deoxy-beta-D-arabino-pentofuranosyl)guanine, a potential antitumor agent against B-lymphoma infected with Kaposi's sarcoma-associated herpesvirus.
Several 9-(2-C-cyano-2-deoxy-l-beta-D-arabino-pentofuranosyl)purine derivatives were tested against Kaposi's sarcoma-associated herpesvirus (KSHV)-infected primary effusion lymphoma (PEL) cells. The guanine derivative (2, CNDAG) as well as the 2-amino-6-substituted-purine derivatives 3, 4 and 5 inhibited KSHV-positive cell growth but showed no cytotoxicity against KSHV-negative cells at >15 muM concentrations. Therefore, it was found that compounds 2, 3, 4 and 5 showed selective cytotoxicity against PEL cells infected with KSHV.
Ichikawa
Satoshi
S
Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan. ichikawa@pharm.hokudai.ac.jp
Otawa
Masaki
M
Teishikata
Yasuhiro
Y
Yamada
Koji
K
Fujimuro
Masahiro
M
Yokosawa
Hideyoshi
H
Matsuda
Akira
A
D000964:Antimetabolites, Antineoplastic / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D001087:Arabinonucleosides / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D002460:Cell Line; D002461:Cell Line, Transformed; D006151:Guanosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use; D019288:Herpesvirus 8, Human; D006801:Humans; D016393:Lymphoma, B-Cell / Q000188:drug therapy*; D012514:Sarcoma, Kaposi / Q000188:drug therapy*
C520639:9-(2-C-cyano-2-deoxy-arabino-pentofuranosyl)guanine; D000964:Antimetabolites, Antineoplastic; D001087:Arabinonucleosides; D006151:Guanosine