title: Two "childhood" malignancies in an elderly individual: a case report and discussion.
abstract: Rhabdomyosarcoma (RMS) is the most common soft-tissue tumor in childhood, but is extremely rare in elderly. We present a rare case of cardiac RMS, which developed 1 year after the diagnosis and management of acute lymphoblastic leukemia in a 68-year-old female. The occurrence of such phenomena is intriguing, especially in an individual without prior history of malignancy at a younger age. Through the review of the existing literature, we attempt to approach the pathogenesis and clinical manifestations of this rare clinical entity.
authors.affiliation: Department of Internal Medicine, Hahnemann University Hospital/Drexel University College of Medicine, Philadelphia, PA 19102, USA.
authors.forename: Lohith S
authors.initials: LS
authors.lastname: Bachegowda
authors.forename: Gayathri
authors.initials: G
authors.lastname: Nagaraj
authors.forename: Petros D
authors.initials: PD
authors.lastname: Grivas
authors.forename: Lingyi
authors.initials: L
authors.lastname: Chen
authors.forename: Eugene
authors.initials: E
authors.lastname: Choi
authors.forename: Michael
authors.initials: M
authors.lastname: Styler
mesh_terms: D017668:Age of Onset; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D006338:Heart Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000473:pathology; D006801:Humans; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis / Q000209:etiology; D016609:Neoplasms, Second Primary / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000473:pathology; D012208:Rhabdomyosarcoma / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000473:pathology; D013997:Time Factors