Assessment of the corticospinal tract alterations before and after resection of brainstem lesions using Diffusion Tensor Imaging (DTI) and tractography at 3T.
The purpose of the study was to investigate the role of Diffusion Tensor Imaging (DTI) and Diffusion Tensor Tractography (DTT) on the corticospinal tract alterations due to space occupying lesions in the brainstem before and after surgical resection. Pre- and post-surgical DTI data were acquired in 14 patients undergoing surgical resection of brainstem lesions. Patterns of corticospinal tract (CST) alteration on DTT were compared with the neurological exams of the patients pre- and post-operatively. DTT, especially in 3D movie format, seemed very helpful for evaluating the relationship of the lesions with the corticospinal tracts for surgical approach. None of the patients developed additional motor deficit related to surgery except one patient who presented with cerebellar ataxia after surgery. All of the patients with normal CST on DTT presented without motor deficit on neurological exam. The sensitivity, specificity, positive predictive and negative predictive values of DTT before surgery were 100%, 63.6%, 42.9% and 100%, and the corresponding values after surgery were 100%, 96%, 75% and 100% respectively. Although it has low specificity before surgery, DTT is a potentially useful technique in evaluating the effects of brainstem lesions and surgical resection on the relevant corticospinal tracts with high negative predictive value and higher specificity after surgery.
Kovanlikaya
Ilhami
I
Department of Radiology, Weill Cornell Medical College, New York, NY 10021, United States. ilk2002@med.cornell.edu
Firat
Zeynep
Z
Kovanlikaya
Arzu
A
Uluğ
Aziz M
AM
Cihangiroglu
M Mutlu
MM
John
Majnu
M
Bingol
Canan Aykut
CA
Ture
Ugur
U
D000293:Adolescent; D000328:Adult; D000368:Aged; D020295:Brain Stem Neoplasms / Q000473:pathology* / Q000601:surgery*; D056324:Diffusion Tensor Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011300:Preoperative Care / Q000379:methods; D011379:Prognosis; D011712:Pyramidal Tracts / Q000473:pathology*; D016896:Treatment Outcome; D055815:Young Adult