title: Stability of the JP2 clone of Aggregatibacter actinomycetemcomitans.
abstract: The JP2 clone of Aggregatibacter actinomycetemcomitans is strongly associated with aggressive periodontitis. To obtain information about colonization dynamics of the JP2 clone, we used PCR to examine its presence in 365 Moroccan juveniles from whom periodontal plaque samples were collected at baseline and after one and two years. Periodontal attachment loss was measured at baseline and at the two-year follow-up. At baseline, 43 (12%) carriers of the JP2 clone were found. Nearly half (44 %) of these were persistently colonized with the clone. The relative risk for the development of aggressive periodontitis, adjusted for the concomitant presence of other genotypes of A. actinomycetemcomitans, was highest for individuals continuously infected by the JP2 clone (RR = 13.9; 95% CI, 9.0 to 21.4), indicating a relationship between infectious dose and disease, which further substantiates the evidence for the JP2 clone as a causal factor in aggressive periodontitis.
authors.affiliation: Department of Pediatric Dentistry, School of Dentistry, Vennelyst Boulevard 9, DK-8000 Aarhus C, Denmark. dhaubek@odont.au.dk
authors.forename: D
authors.initials: D
authors.lastname: Haubek
authors.forename: O-K
authors.initials: OK
authors.lastname: Ennibi
authors.forename: M
authors.initials: M
authors.lastname: Vaeth
authors.forename: S
authors.initials: S
authors.lastname: Poulsen
authors.forename: K
authors.initials: K
authors.lastname: Poulsen
mesh_terms: D000189:Actinobacillus Infections / Q000382:microbiology*; D016976:Aggregatibacter actinomycetemcomitans / Q000235:genetics / Q000472:pathogenicity / Q000502:physiology*; D010520:Aggressive Periodontitis / Q000382:microbiology* / Q000503:physiopathology; D002648:Child; D002999:Clone Cells; D003773:Dental Plaque / Q000382:microbiology; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D005838:Genotype; D054884:Host-Pathogen Interactions; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D009018:Morocco; D017622:Periodontal Attachment Loss / Q000382:microbiology / Q000503:physiopathology; D010514:Periodontal Pocket / Q000382:microbiology / Q000503:physiopathology; D012307:Risk Factors