Antilonomic effects of Brazilian brown seaweed extracts.
The aim of this work was to investigate the hemolysis and blood clotting activity of Lomonia obliqua venom and the ability of some Brazilian marine algal extracts (Canistrocarpus cervicornis, Stypopodium zonale and Dictyota pfaffi) to antagonize such biological activities. L. obliqua caterpillars are dangerous to human beings and envenomation symptoms are characterized by hemorrhagic, hemolytic and blood clotting disorders, and acute renal failure, which sometimes lead to the death of the victims. Through in vitro experiments we have shown that L. obliqua venom is able to clot human plasma and hemolize human erythrocytes and that the coagulation activity of the venom is inhibited by the extracts of C. cervicornis, S. zonale and D. pfaffi. In contrast, C. cervicornis and S. zonale extracts did not inhibit the hemolytic activity of L. oblqua, as did the extract of D. pfaffi. These finding indicate that marine algae may be used as antivenoms or may contribute to the development of compounds with antilonomic effects.
Domingos
Thaisa Francielle Souza
TF
Departamento de Biologia Molecular e Celular, Instituto de Biologia, Universidade Federal Fluminense, Niterói, RJ, Brazil.
Carvalho
Carla
C
Moura
Laura de Andrade
Lde A
Teixeira
Valéria Laneuville
VL
Pereira
Renato Crespo
RC
Bianco
Everson Miguel
EM
Ferreira
Wilton José
WJ
Ramos
Carlos José Brito
CJ
de Miranda
Ana Luiza Palhares
AL
Melo
Paulo Assis
PA
Guimarães
Jorge Almeida
JA
Fuly
André Lopes
AL
D058186:Acute Kidney Injury / Q000139:chemically induced; D000818:Animals; D001778:Blood Coagulation Disorders / Q000139:chemically induced; D001938:Brazil; D004912:Erythrocytes / Q000187:drug effects; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D007814:Larva; D009036:Moths / Q000737:chemistry / Q000254:growth & development; D000459:Phaeophyceae / Q000737:chemistry*; D012624:Seaweed / Q000737:chemistry*; D014688:Venoms / Q000302:isolation & purification / Q000633:toxicity*
D014688:Venoms