Chlamydia trachomatis, Mycoplasma genitalium, Neisseria gonorrhoeae, human papillomavirus, and polyomavirus are not detectable in human tissue with epithelial ovarian cancer, borderline tumor, or benign conditions.
OBJECTIVE
We sought to analyze the presence of the microorganisms Chlamydia trachomatis, Mycoplasma genitalium, Neisseria gonorrhoeae, human papillomavirus (HPV), and the polyomaviruses BK virus (BKV) and JC virus (JCV) in ovarian tissues of women with ovarian carcinomas, borderline tumors, and benign conditions.


METHODS
Ovarian tissue, snap-frozen and stored at -80 degrees C, from 186 women with benign conditions, borderline tumors, and epithelial ovarian cancer, as well as tissue from the contralateral ovary of 126 of these women, were analyzed regarding presence of C trachomatis and N gonorrhoeae (transcription mediated amplification), M genitalium (real-time polymerase chain reaction [PCR]), HPV (PCR), and BKV and JCV (PCR).


RESULTS
All the tissue samples studied were found negative for the microorganisms analyzed.


CONCLUSIONS
C trachomatis, M genitalium, N gonorrhoeae, HPV, and the polyomaviruses BKV and JCV are not detectable in ovarian tissues either from women with benign conditions and borderline tumors or from women with ovarian cancer.
Idahl
Annika
A
Department of Clinical Science/Obstetrics and Gynecology, Umeå University, Sweden.
Lundin
Eva
E
Elgh
Fredrik
F
Jurstrand
Margaretha
M
Møller
Jens K
JK
Marklund
Ingrid
I
Lindgren
Peter
P
Ottander
Ulrika
U
D000328:Adult; D000368:Aged; D052685:Alphapapillomavirus / Q000302:isolation & purification; D001739:BK Virus / Q000302:isolation & purification*; D002692:Chlamydia trachomatis / Q000302:isolation & purification*; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D005831:Genital Diseases, Female / Q000821:virology*; D006801:Humans; D007577:JC Virus / Q000302:isolation & purification*; D008875:Middle Aged; D045704:Mycoplasma genitalium / Q000302:isolation & purification; D009344:Neisseria gonorrhoeae / Q000302:isolation & purification; D010051:Ovarian Neoplasms / Q000821:virology*; D010053:Ovary / Q000821:virology*; D016133:Polymerase Chain Reaction
D004279:DNA, Viral