title: High safety profile and activity of oral vinorelbine in an elderly patient with metastatic breast cancer.
abstract: Visceral metastases of breast cancer have been commonly treated with "aggressive" anthracyclines/taxanes-based chemotherapy. In contrast, this case report concerns an elderly patient with advanced breast cancer (pleural effusion, peritoneal carcinosis, and bone metastases) who firmly declined intravenous chemotherapy and was treated for a long time (28 months) with oral vinorelbine. The oral formulation of this drug had activity and a high safety profile, enabling the patient's wishes to be respected.
authors.affiliation: Operative Oncology Unit, S. Salvatore Hospital, Pesaro, Italy. d.rossi63@libero.it
authors.forename: David
authors.initials: D
authors.lastname: Rossi
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Baldelli
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Catalano
authors.forename: Virginia
authors.initials: V
authors.lastname: Casadei
authors.forename: Paolo
authors.initials: P
authors.lastname: Alessandroni
authors.forename: Paolo
authors.initials: P
authors.lastname: Giordani
authors.forename: Francesco
authors.initials: F
authors.lastname: Graziano
authors.forename: Stefano Luzi
authors.initials: SL
authors.lastname: Fedeli
mesh_terms: D000284:Administration, Oral; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000188:drug therapy / Q000556:secondary; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010996:Pleural Effusion / Q000175:diagnosis / Q000209:etiology; D013997:Time Factors; D014747:Vinblastine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000077235:Vinorelbine
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D014747:Vinblastine; D000077235:Vinorelbine