title: Prediction and identification of tumor-specific noncoding RNAs from human UniGene.
abstract: Noncoding RNAs (ncRNAs) have been proven to actively participate in many diverse biologic processes. Some ncRNAs are strongly associated with tumorigenesis and could thus be regarded as tumor markers, or even as candidate therapeutic targets. In this study, we computationally analyzed the human UniGene dataset to predict potential tumor-specific ncRNAs, and then verified our predictions experimentally. We demonstrated that two of our predicted ncRNAs showed tumor-specific expression in non-small cell lung cancer and endometrial carcinoma, respectively. Genomic analysis of these two ncRNAs suggests that they might play significant roles in tumorigenesis and are therefore worthy of further investigation.
authors.affiliation: Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, No.1 Shuai-fu-yuan, Wang-fu-jing, 100730, Beijing, China.
authors.forename: Xinting
authors.initials: X
authors.lastname: Sang
authors.forename: Haitao
authors.initials: H
authors.lastname: Zhao
authors.forename: Xin
authors.initials: X
authors.lastname: Lu
authors.forename: Yilei
authors.initials: Y
authors.lastname: Mao
authors.forename: Ruoyu
authors.initials: R
authors.lastname: Miao
authors.forename: Huayu
authors.initials: H
authors.lastname: Yang
authors.forename: Yifan
authors.initials: Y
authors.lastname: Yang
authors.forename: Jiefu
authors.initials: J
authors.lastname: Huang
authors.forename: Shouxian
authors.initials: S
authors.lastname: Zhong
mesh_terms: D001483:Base Sequence; D002277:Carcinoma / Q000737:chemistry / Q000235:genetics; D002289:Carcinoma, Non-Small-Cell Lung / Q000737:chemistry / Q000235:genetics; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D019295:Computational Biology; D017124:Conserved Sequence; D030561:Databases, Nucleic Acid; D016889:Endometrial Neoplasms / Q000737:chemistry / Q000235:genetics; D020224:Expressed Sequence Tags; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000737:chemistry / Q000235:genetics; D008969:Molecular Sequence Data; D009928:Organ Specificity; D012334:RNA, Neoplasm / Q000032:analysis / Q000235:genetics*; D022661:RNA, Untranslated / Q000032:analysis / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D012334:RNA, Neoplasm; D022661:RNA, Untranslated