[Treatment of homozygous familial hypercholesterolemia with LDL-apheresis on a 4-year-old child].
Homozygous familial hypercholesterolemia (HFH) is a rare genetic disease associated with increased atherosclerosis, resulting in premature death near the age of 20 years. Treatment requires the LDL-apheresis system. M, born from a consanguineous union, suffers from HFH (total-cholesterol=12.29 g/l, LDL-cholesterol=9.65 g/l). Diet and drug treatment was not associated with decreased LDL-cholesterol. At the age of 4.5 years (body weight: 16.7 kg), M began treatment with LDL-apheresis. Apheresis treatment was given every 2 weeks using the Direct Adsorption of LIpoprotein (DALI system, a process that involves total-blood filtration. During the first 26 sessions, the mean reduction in LDL-cholesterol was 67+/-12%, while HDL-cholesterol decreased by only 17+/-11%. Mean LDL-cholesterol concentration decreased from 6.54+/-0.93 g/l (before apheresis) to 2.21+/-0.95 g/l (after apheresis). Apart from iron deficiency anemia, no major side effects were observed. LDL-apheresis using the DALI system is associated with significant reductions in LDL-cholesterol (similar to reports from the literature) without major side effects, even in a child weighing less than 20 kg. A long term, multinational (European) study is needed to confirm these results.
Lefort
B
B
Département Médicochirurgical de Pédiatrie-Nutrition de l'Enfant, CHU de Poitiers, Poitiers, France. bruno.lefort@etu.univ-poitiers.fr
Giraud
C
C
Saulnier
J-P
JP
Bott
L
L
Gambert
C
C
Sosner
P
P
Hankard
R
R
D015415:Biomarkers / Q000097:blood; D001781:Blood Component Removal / Q000379:methods*; D015992:Body Mass Index; D002675:Child, Preschool; D002784:Cholesterol / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood*; D003241:Consanguinity; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000097:blood / Q000150:complications / Q000628:therapy*; D008074:Lipoproteins / Q000097:blood; D008297:Male; D016896:Treatment Outcome
D015415:Biomarkers; D008078:Cholesterol, LDL; D008074:Lipoproteins; D002784:Cholesterol