The impact of PET/CT on therapeutic strategy of patients with colorectal cancer metastasis.
OBJECTIVE
The study's aim was to assess the impact of the PET/CT on the therapeutic strategy of the patients with colorectal cancer metastasis.


METHODS
Fifteen patients who were suspicious of postoperative colorectal cancer metastasis were included in the study. Each patient received a positron emission tomography/computed tomography (PET/CT) after received contrast-enhanced computed tomography (ceCT). The therapeutic strategies were made before and after the PET/ CT respectively. The lesions confirmed by pathology or periodic follow up of ceCT (3 and 6 mo).


RESULTS
Intrahepatic metastases were present in 5 of the 15 patients, total 9 lesions. The specificities of the PET/CT and ceCT were 100%. The patients with intrahepatic metastases were detected by PET/CT and ceCT with a sensitivity of 100% and 80%, respectively (p = 0.0009). Extrahepatic metastases were present in 11 of the 15 patients, total 32 lesions. The specificities of the PET/CT and ceCT were 75% and 50%, respectively. PET/ CT and ceCT were with a sensitivity of 100% and 63.6%, respectively (p = 0.0177). The therapeutic strategies were changed after received PET/CT in 6 (40%) of the 15 patients.


CONCLUSIONS
PET/CT is superior to ceCT for the detection of the metastatic lesions of the colorectal cancer, and is a valuable tool to help select the correct therapeutic strategies.
Liu
Yan-Nan
YN
Department of General Surgery, Beijing Hospital, Beijing, China.
Huang
Mei-Xiong
MX
An
Qi
Q
Wei
Jun-Min
JM
D000328:Adult; D000368:Aged; D015179:Colorectal Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D003287:Contrast Media; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis / Q000000981:diagnostic imaging* / Q000473:pathology; D014055:Tomography, Emission-Computed / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000379:methods*
D003287:Contrast Media