Alpha-glucosidase inhibitory, aromatase inhibitory, and antiplasmodial activities of a biflavonoid GB1 from Garcinia kola stem bark.
The biflavonoid, 3'',4',4''',5,5'',7,7''-heptahydroxy-3,8-biflavanone, known as GB1 (1), was isolated as a major constituent from Garcinia kola stem bark. GB1 (1) exhibited alpha-glucosidase and aromatase inhibitory activities, as well as antiplasmodial activity, but was not toxic against cell lines tested. GB1 (1) may be a potential dietary supplement or phytomedicine for the prevention of breast cancer and type 2 diabetes mellitus.
Antia
Bassey S
BS
Chulabhorn Research Institute, Vibhavadi-Rangsit Highway, Bangkok, Thailand.
Pansanit
Acharavadee
A
Ekpa
Okon D
OD
Ekpe
Udofot J
UJ
Mahidol
Chulabhorn
C
Kittakoop
Prasat
P
D000962:Antimalarials / Q000302:isolation & purification / Q000494:pharmacology*; D047072:Aromatase Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D044946:Biflavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D029763:Garcinia kola / Q000737:chemistry*; D065089:Glycoside Hydrolase Inhibitors; D024301:Plant Bark; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018547:Plant Stems
C549907:3',4',4',5,5',7,7'-heptahydroxy-3,8-biflavanone; D000962:Antimalarials; D047072:Aromatase Inhibitors; D044946:Biflavonoids; D004791:Enzyme Inhibitors; D065089:Glycoside Hydrolase Inhibitors; D010936:Plant Extracts