[Control of adipogenesis by fatty acids].
Obesity is one of the major Public Health problems. Obese individuals are more susceptible to develop cardiovascular diseases and type 2 diabetes mellitus. The obesity results from the increase in size and number of the adipocytes. The balance between adipogenesis and adiposity determines the degree of obesity. Mature adipocytes secrete adipokines, such as TNFalpha, IL-6, leptine and adiponectin, and lipokine, the palmitoleic acid omega-7. The production of adipokines is increased in obesity, contributing to the onset of peripheral insulin resistance. The knowledge about the molecular events that regulate the differentiation of pre-adipocytes and mesenchymal stem cells into adipocytes (adipogenesis) is important for the comprehension of the genesis of obesity. Activation of transcription factor PPARgamma plays an essential role in the adipogenesis. Certain fatty acids are PPARgamma ligands and can control adipogenesis. Moreover, some fatty acids act as signaling molecules regulating their differentiation into adipocytes or death. Accordingly, the lipid composition of the diet and PPARgamma agonists can regulate the balance between adipogenesis and death of adipocytes and, therefore, the obesity.
Queiroz
Jean César Farias de
JC
Laboratório de Fisiologia Celular, Departamento de Fisiologia e Biofísica, ICB, USP, São Paulo, SP, Brasil.
Alonso-Vale
Maria Isabel Cardoso
MI
Curi
Rui
R
Lima
Fabio Bessa
FB
D050156:Adipogenesis / Q000187:drug effects / Q000502:physiology*; D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D002318:Cardiovascular Diseases / Q000209:etiology / Q000517:prevention & control; D005227:Fatty Acids / Q000378:metabolism* / Q000627:therapeutic use; D006801:Humans; D044243:Linoleic Acids, Conjugated / Q000378:metabolism; D009765:Obesity / Q000378:metabolism*; D047492:Peroxisome Proliferator-Activated Receptors / Q000378:metabolism*
D005227:Fatty Acids; D044243:Linoleic Acids, Conjugated; D047492:Peroxisome Proliferator-Activated Receptors