Platelet hyperactivity during exercise leading to iterative coronary stent thrombosis: clinical implications.
Exercise may induce platelet activation in spite of using antiplatelet treatment. We present a case where the initial acute coronary syndrome and the iterative stent thrombosis always occurred after intense and prolonged physical effort. For this patient the at rest response to platelet inhibition with antiplatelet treatments was assessed as adequate, but after exercise the patient developed platelet activation which could be the trigger of his stent thrombosis.
Ormezzano
Olivier
O
Department of Cardiology, Grenoble University Hospital, Grenoble, France. OOrmezzano@chu-grenoble.fr
Polack
Benoit
B
Vanzetto
Gérald
G
Sahnoun
Mohamed
M
Machecourt
Jacques
J
D023903:Coronary Restenosis / Q000209:etiology*; D003328:Coronary Thrombosis / Q000150:complications / Q000628:therapy*; D015444:Exercise / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015539:Platelet Activation / Q000502:physiology*; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D012008:Recurrence; D015607:Stents
D010975:Platelet Aggregation Inhibitors