title: Synthesis and anti-HCV activity of 2',5'-deoxy-5'-phenacyladenosine analogs.
abstract: Several nucleoside analogs containing a methylene group instead of a 5'-O atom were synthesized to study the effect of the 5'-modification of nucleoside analogs on their anti-HCV activity. Among the analogs, a 5'-phenacyl analog exhibited good anti-HCV activity with an EC(50) of 15.1 muM. This compound is hypothesized to function via a novel type of mechanism that does not involve the conventional 5'-O-triphosphorylation process.
authors.affiliation: Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University, Sanuki, Kagawa 769-2193, Japan. ikejim@osaka-ohtani.ac.jp
authors.forename: Masahiro
authors.initials: M
authors.lastname: Ikejiri
authors.forename: Takayuki
authors.initials: T
authors.lastname: Ohshima
authors.forename: Akemi
authors.initials: A
authors.lastname: Fukushima
authors.forename: Kunitada
authors.initials: K
authors.lastname: Shimotohno
authors.forename: Tokumi
authors.initials: T
authors.lastname: Maruyama
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D003853:Deoxyribonucleosides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D016174:Hepacivirus / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents; D003853:Deoxyribonucleosides; D000241:Adenosine