title: Harnessing human dendritic cell subsets to design novel vaccines.
abstract: Dendritic cells (DCs) orchestrate a repertoire of immune responses that endow resistance to infection and tolerance to self. DC plasticity and subsets are prominent determinants of the quality of elicited immune responses. Different DC subsets display different receptors and surface molecules and express different sets of cytokines/chemokines, all of which lead to distinct immunological outcomes. Recent findings on human DC subsets and their functional specialization have provided insights for the design of novel human vaccines.
authors.affiliation: Baylor Institute for Immunology Research, Dallas, TX 75204, USA. jacquesb@baylorhealth.edu
authors.forename: Jacques
authors.initials: J
authors.lastname: Banchereau
authors.forename: Eynav
authors.initials: E
authors.lastname: Klechevsky
authors.forename: Nathalie
authors.initials: N
authors.lastname: Schmitt
authors.forename: Rimpei
authors.initials: R
authors.lastname: Morita
authors.forename: Karolina
authors.initials: K
authors.lastname: Palucka
authors.forename: Hideki
authors.initials: H
authors.lastname: Ueno
mesh_terms: D015703:Antigens, CD / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology; D019496:Cancer Vaccines / Q000276:immunology*; D016207:Cytokines / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology*; D020405:Dermis / Q000276:immunology; D015195:Drug Design; D004817:Epidermis / Q000276:immunology; D006801:Humans; D007109:Immunity; D007239:Infections / Q000276:immunology; D018664:Interleukin-12 / Q000276:immunology; D007801:Langerhans Cells / Q000276:immunology; D009369:Neoplasms / Q000276:immunology*; D017634:Self Tolerance; D012867:Skin / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology
chemical_list: D015703:Antigens, CD; D019496:Cancer Vaccines; D016207:Cytokines; D018664:Interleukin-12