[New bone imaging techniques in children with chronic kidney disease].
Bone damage in the spectrum of chronic kidney disease - mineral and bone disorders (CKD-MBD) represents a daily challenge for pediatric nephrologists. A real measurement of bone mineral density (BMD) by Dual X-ray absorptiometry (DXA) is currently performed to evaluate bone mass in children. However this technique has some limitations. In 2000, the National Institute of Health (NIH) has defined new "quality" criteria for the diagnosis of osteoporosis in addition to a decreased bone mass. Bone strength actually integrates 2 issues: bone density and bone quality (i.e., micro architectural organization, bone turnover, mineralization and micro fractures). These "quality" criteria cannot be evaluated by DXA. Histomorphometry remains the gold standard to evaluate bone but it is rarely performed in clinical practice. New bone imaging techniques have thus been developed, leading to an improvement in bone assessment. They are particularly challenging in children, whose bones continually grow in size, shape and mass.
Bacchetta
J
J
Centre de référence des maladies rénales rares, service de néphrologie et rhumatologie pédiatriques, hôpital Femme-mère-enfant, 59 boulevard Pinel, Bron cedex, France. monios@hotmail.com
Boutroy
S
S
Delmas
P-D
PD
Cochat
P
P
D015502:Absorptiometry, Photon; D015519:Bone Density / Q000502:physiology; D001842:Bone and Bones / Q000473:pathology; D002648:Child; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000175:diagnosis*; D003952:Diagnostic Imaging; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D007676:Kidney Failure, Chronic / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography