Impact of female age and male infertility on ovarian reserve markers to predict outcome of assisted reproduction technology cycles.
BACKGROUND
This study was designed to assess the capability of ovarian reserve markers, including baseline FSH levels, baseline anti-Müllerian hormone (AMH) levels, and antral follicle count (AFC), as predictors of live births during IVF cycles, especially for infertile couples with advanced maternal age and/or male factors.


METHODS
A prospective cohort of 336 first IVF/ICSI cycles undergoing a long protocol with GnRH agonist was investigated. Patients with endocrine disorders or unilateral ovaries were excluded.


RESULTS
Among the ovarian reserve tests, AMH and age had a greater area under the receiving operating characteristic curve than FSH in predicting live births. Furthermore, AMH and age were the sole predictive factors of live births for women greater than or equal to 35 years of age; while AMH was the major determinant of live births for infertile couples with absence of male factors by multivariate logistic regression analysis. However, all the studied ovarain reserve tests were not preditive of live births for women < 35 years of age or infertile couples with male factors.


CONCLUSIONS
The serum AMH levels were prognostic for pregnancy outcome for infertile couples with advanced female age or absence of male factors. The predictive capability of ovarian reserve tests is clearly influenced by the etiology of infertility.
Lee
Tsung-Hsien
TH
Department of Obstetrics and Gynecology, Chung Shan Medical University Hospital, Taichung, Taiwan, Republic of China.
Liu
Chung-Hsien
CH
Huang
Chun-Chia
CC
Hsieh
Kung-Chen
KC
Lin
Pi-Mei
PM
Lee
Maw-Sheng
MS
D000328:Adult; D000367:Age Factors; D054304:Anti-Mullerian Hormone / Q000097:blood / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood / Q000378:metabolism*; D005260:Female; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000097:blood / Q000378:metabolism; D006801:Humans; D007248:Infertility, Male / Q000503:physiopathology*; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D009865:Oocytes / Q000166:cytology; D010053:Ovary / Q000166:cytology / Q000378:metabolism*; D011237:Predictive Value of Tests; D011247:Pregnancy; D011256:Pregnancy Outcome; D011379:Prognosis; D027724:Reproductive Techniques, Assisted; D020554:Sperm Injections, Intracytoplasmic
D015415:Biomarkers; D054304:Anti-Mullerian Hormone; D005640:Follicle Stimulating Hormone