Ionic liquid-based ultrasound-assisted extraction of fangchinoline and tetrandrine from Stephaniae tetrandrae.
An ionic liquid-based ultrasound-assisted extraction method has been developed for the effective extraction of fangchinoline and tetrandrine from Stephaniae tetrandrae. The effects of some ultrasound-assisted extraction parameters including the concentration of [BMIM][BF(4)], pH, ultrasonic power and time were investigated to optimize the ultrasound-assisted extraction conditions. Compared to the regular ultrasound-assisted extraction and traditional refluent extraction, the proposed [BMIM][BF(4)]-based ultrasound-assisted extraction offered shorter extraction times (from 6 h to 40 min) and remarkable higher efficiencies (approximately 30% improved), which supported the suitability of the proposed approach. In addition, the proposed approach was confirmed by the good correlation coefficient (R(2)), recovery and reproducibility (RSD, n = 5), which were in the range of 0.9992-0.9995, 85.5-101.1%, and 1.87-4.33%, respectively.
Zhang
Lijin
L
Shandong Analysis and Test Center, Shandong Academy of Sciences, Jinan, Shandong, China.
Geng
Yanling
Y
Duan
Wenjuan
W
Wang
Daijie
D
Fu
Maorun
M
Wang
Xiao
X
D044182:Benzylisoquinolines / Q000302:isolation & purification*; D004365:Drugs, Chinese Herbal; D052578:Ionic Liquids / Q000737:chemistry*; D015394:Molecular Structure; D031609:Stephania tetrandra / Q000737:chemistry*; D014465:Ultrasonics
D044182:Benzylisoquinolines; D004365:Drugs, Chinese Herbal; D052578:Ionic Liquids; C009438:tetrandrine; C060802:fangchinoline