title: Unbound cephalothin pharmacokinetics in adult burn patients are related to the elapsed time after injury.
abstract: Cephalothin (cefalotin) pharmacokinetics were evaluated for nine severely burned patients (42% +/- 9% mean burn areas) and five healthy volunteers by using non-plasma-protein-bound concentration-time profiles. Burn patients gave increased mean residence times (36%) and reduced total clearances (25%). Mean residence times and distribution volumes increased between 1 and 4 days posttrauma, suggesting that burn patient pharmacokinetics change during the initial fluid resuscitation phase of treatment.
authors.affiliation: University of Queensland, Burns Trauma & Critical Care Research Centre, Royal Brisbane & Women's Hospital, Herston, Brisbane, Queensland, Australia. a.dalley@uq.edu.au
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Dalley
authors.forename: Renae
authors.initials: R
authors.lastname: Deans
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Lipman
authors.forename: Bala
authors.initials: B
authors.lastname: Venkatesh
authors.forename: Michael
authors.initials: M
authors.lastname: Rudd
authors.forename: Michael S
authors.initials: MS
authors.lastname: Roberts
authors.forename: Sheree E
authors.initials: SE
authors.lastname: Cross
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D002056:Burns / Q000188:drug therapy*; D002512:Cephalothin / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D002512:Cephalothin