Nicotine's Allure.
Both conscious and unconscious memory mechanisms contribute to the rewarding effects of nicotine and other drugs of abuse. In this issue of Neuron, Tang and Dani use in vivo measures of synaptic plasticity in freely moving mice to link nicotine-induced dopamine release in hippocampus to LTP induction and behavioral reinforcement.
McGehee
Daniel S
DS
Department of Anesthesia and Critical Care, University of Chicago, 5841 South Maryland Avenue MC4028, Chicago, IL 60637, USA. dmcgehee@uchicago.edu
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D018891:Dentate Gyrus / Q000187:drug effects / Q000502:physiology; D004298:Dopamine / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D006624:Hippocampus / Q000187:drug effects* / Q000502:physiology; D017774:Long-Term Potentiation / Q000187:drug effects* / Q000502:physiology; D051379:Mice; D009538:Nicotine / Q000494:pharmacology*; D018722:Nicotinic Agonists / Q000494:pharmacology*; D012054:Reinforcement, Psychology; D019966:Substance-Related Disorders / Q000503:physiopathology
D018722:Nicotinic Agonists; D009538:Nicotine; D004298:Dopamine