title: Dengue 1 virus and dengue hemorrhagic fever, French Polynesia, 2001.
abstract: An epidemic of dengue 1 virus (DENV-1) occurred in French Polynesia in 2001, 4 years after a DENV-2 epidemic that ended in 1997. Surveillance data from hospitalized case-patients showed that case-patients with dengue hemorrhagic fever (DHF) exhibited a bimodal age distribution with 1 peak among infants 6-10 months of age and a second peak at 4-11 years of age. The relative risk of DHF developing in children born before rather than after the DENV-2 epidemic was 186 (95% confidence interval 26-1,324). Among children born toward the end of the DENV-2 epidemic, a strong temporal association was found between the month of birth and the risk of being hospitalized for DHF. This study documents epidemic pathogenicity associated with the sequence of DENV-2 infection followed by DENV-1 infection.
authors.affiliation: Directorate of Health, Papeete, Tahiti, French Polynesia. bf.hubert@wanadoo.fr
authors.forename: Bruno
authors.initials: B
authors.lastname: Hubert
authors.forename: Scott B
authors.initials: SB
authors.lastname: Halstead
mesh_terms: D000293:Adolescent; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D021821:Communicable Diseases, Emerging / Q000453:epidemiology* / Q000821:virology*; D003716:Dengue Virus / Q000145:classification* / Q000302:isolation & purification; D004196:Disease Outbreaks; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D011114:Polynesia / Q000453:epidemiology; D012307:Risk Factors; D012703:Serotyping; D019595:Severe Dengue / Q000453:epidemiology* / Q000821:virology*; D013997:Time Factors; D055815:Young Adult