title: In vivo selection of carbapenem-resistant Klebsiella pneumoniae by OmpK36 loss during meropenem treatment.
abstract: We recovered a carbapenem-resistant Klebsiella pneumoniae isolate H224 under in vivo meropenem selection pressure. Insertional inactivation of a major porin gene, ompK36, by IS5 element might play a role in acquiring carbapenem resistance in this strain harboring plasmid-borne DHA-1 AmpC beta-lactamase.
authors.affiliation: Department of Laboratory Medicine, Hallym University College of Medicine, 120-950 Seoul, Republic of Korea.
authors.forename: Wonkeun
authors.initials: W
authors.lastname: Song
authors.forename: Borum
authors.initials: B
authors.lastname: Suh
authors.forename: Jun Yong
authors.initials: JY
authors.lastname: Choi
authors.forename: Seok Hoon
authors.initials: SH
authors.lastname: Jeong
authors.forename: Eun Hee
authors.initials: EH
authors.lastname: Jeon
authors.forename: Young Ki
authors.initials: YK
authors.lastname: Lee
authors.forename: Seong Geun
authors.initials: SG
authors.lastname: Hong
authors.forename: Kyungwon
authors.initials: K
authors.lastname: Lee
mesh_terms: D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001426:Bacterial Proteins / Q000235:genetics*; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D005260:Female; D017353:Gene Deletion; D006801:Humans; D007710:Klebsiella Infections / Q000188:drug therapy* / Q000382:microbiology; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D000077731:Meropenem; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D010957:Plasmids; D018272:Porins / Q000235:genetics*; D012641:Selection, Genetic; D017422:Sequence Analysis, DNA; D013845:Thienamycins / Q000627:therapeutic use*; D018440:beta-Lactam Resistance
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D004269:DNA, Bacterial; C092233:OmpK36 protein, Klebsiella pneumoniae; D018272:Porins; D013845:Thienamycins; D000077731:Meropenem