[Antidepressant use in children and adolescents].
Relative to placebo, selective serotonin reuptake inhibitors (SSRI) are efficacious for paediatric affective disorders, although their clinical effects appear relatively modest in major depressive disorder, intermediate in obsessive-compulsive disorder, and stronger in anxiety disorders. If SSRIs modestly increase the risk of occurrence of suicidal ideation and behavior, several studies show that their use is associated with a significant decrease in the suicide rates in children and adolescents, probably because of their efficacy, compliance, and low toxicity in overdose.
Bailly
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Pôle universitaire de psychiatrie, hôpital Sainte-Marguerite, 270 boulevard de Sainte-Marguerite, Marseille, France. daniel.bailly@ap-hm.fr
D000293:Adolescent; D000928:Antidepressive Agents / Q000627:therapeutic use*; D002648:Child; D011307:Drug Prescriptions / Q000592:standards; D006801:Humans; D001523:Mental Disorders / Q000188:drug therapy*
D000928:Antidepressive Agents