Reflections on the epileptic encephalopathies.
Although the epileptic encephalopathies have a profound impact on neurological development, there has been limited progress made in the successful treatment of these disorders. This article suggests that the limited understanding of the pathophysiology of the encephalopathies, the lack of a good animal model of these disorders, the failure to understand the impact of etiology on response to treatment, and the absence of a reliable method for measurement of cognitive change in response to treatment are factors that contribute to the limited progress.
Farrell
Kevin
K
Division of Neurology, British Columbia's Childrens Hospital, Vancouver and Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada.
D000818:Animals; D001921:Brain; D002540:Cerebral Cortex / Q000503:physiopathology*; D003072:Cognition Disorders / Q000209:etiology; D004195:Disease Models, Animal; D004827:Epilepsy / Q000473:pathology* / Q000503:physiopathology* / Q000628:therapy; D006801:Humans