title: Synthesis and preliminary biological evaluations of [18F]-1-deoxy-1-fluoro-scyllo-inositol.
abstract: A novel PET radiotracer, [18F]-1-deoxy-1-fluoro-scyllo-inositol, was synthesized via a one-pot reaction in 16 +/- 3% uncorrected radiochemical yield within 80 minutes; although this compound revealed low brain penetration it shows promise in rodent tumour models for breast cancer imaging.
authors.affiliation: PET Centre, Centre for Addiction and Mental Health, 250 College St., Toronto, ON, Canada M5T 1R8. neil.vasdev@camhpet.ca
authors.forename: Neil
authors.initials: N
authors.lastname: Vasdev
authors.forename: Jason
authors.initials: J
authors.lastname: Chio
authors.forename: Erik M
authors.initials: EM
authors.lastname: van Oosten
authors.forename: Mark
authors.initials: M
authors.lastname: Nitz
authors.forename: Joanne
authors.initials: J
authors.lastname: McLaurin
authors.forename: Douglass C
authors.initials: DC
authors.lastname: Vines
authors.forename: Sylvain
authors.initials: S
authors.lastname: Houle
authors.forename: Raymond M
authors.initials: RM
authors.lastname: Reilly
authors.forename: Alan A
authors.initials: AA
authors.lastname: Wilson
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D005462:Fluorine Radioisotopes / Q000737:chemistry; D006801:Humans; D007294:Inositol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D008297:Male; D051379:Mice; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D013237:Stereoisomerism; D014183:Transplantation, Heterologous
chemical_list: C544911:(18F)-1-deoxy-1-fluoro-scyllo-inositol; D005462:Fluorine Radioisotopes; D019275:Radiopharmaceuticals; D007294:Inositol