title: Effect on de novo plaque formation of rinsing with toothpaste slurries and water solutions with a high fluoride concentration (5,000 ppm).
abstract: The aim of this study was to evaluate the effect, on de novo plaque formation, of rinsing with toothpaste slurries and water solutions containing a high concentration of fluoride (F). Sixteen subjects rinsed three times per day for 4 d with dentifrice slurries containing 5,000, 1,500, and 500 ppm F, while 12 subjects rinsed with water solutions containing 5,000, 1,500, 500, and 0 ppm F, and 1.5% sodium lauryl sulphate (SLS). Plaque was scored [using the Quigley & Hein index (QHI)] after each 4-d period. Plaque samples for F analysis were collected. Significantly less plaque was scored for the dentifrice slurry containing 5,000 ppm F (buccal and all surfaces) and for 1.5% SLS (buccal surfaces). The differences in plaque scores between dentifrice containing 5,000 and 1,500 ppm F were 19% for all surfaces and 33% for buccal surfaces. The difference between the water solutions containing 1.5% SLS and 1,500 ppm F for buccal surfaces was 23%; the corresponding difference for 5,000 ppm F was 17%. The dentifrice slurry containing 5,000 ppm F accumulated 56% more F in plaque. The combination of high levels of F and SLS in dentifrice reduces de novo plaque formation and increases the accumulation of F in plaque after 4 d.
authors.affiliation: Department of Cariology, Institute of Odontology, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Nordström
authors.forename: C
authors.initials: C
authors.lastname: Mystikos
authors.forename: P
authors.initials: P
authors.lastname: Ramberg
authors.forename: D
authors.initials: D
authors.lastname: Birkhed
mesh_terms: D000328:Adult; D002327:Cariostatic Agents / Q000008:administration & dosage / Q000032:analysis / Q000627:therapeutic use*; D018592:Cross-Over Studies; D003773:Dental Plaque / Q000737:chemistry / Q000209:etiology*; D003774:Dental Plaque Index; D004311:Double-Blind Method; D005459:Fluorides / Q000008:administration & dosage / Q000032:analysis / Q000627:therapeutic use*; D005460:Fluorides, Topical / Q000008:administration & dosage / Q000627:therapeutic use; D005500:Follow-Up Studies; D006801:Humans; D009067:Mouthwashes / Q000008:administration & dosage / Q000627:therapeutic use; D016037:Single-Blind Method; D012967:Sodium Dodecyl Sulfate / Q000008:administration & dosage / Q000627:therapeutic use; D012969:Sodium Fluoride / Q000008:administration & dosage / Q000627:therapeutic use; D013501:Surface-Active Agents / Q000008:administration & dosage / Q000627:therapeutic use; D014100:Toothpastes / Q000008:administration & dosage / Q000627:therapeutic use*; D014867:Water; D055815:Young Adult
chemical_list: D002327:Cariostatic Agents; D005460:Fluorides, Topical; D009067:Mouthwashes; D013501:Surface-Active Agents; D014100:Toothpastes; C023807:sodium fluoride topical preparation; D014867:Water; D012967:Sodium Dodecyl Sulfate; D012969:Sodium Fluoride; D005459:Fluorides