title: [Phosphorus magnetic resonance spectroscopy: Brain pathologies applications].
abstract: Until recent years, brain applications of (31)P magnetic resonance spectroscopy were poor. Arising of clinical high field strength magnets (three Tesla) as well as dedicated brain coils (eg: bird cage), using specific and useful sequences providing appropriate spatial localisation and signal to noise ratio brought highlights on multinuclear spectroscopy. Better understanding of brain metabolism emphasizes the role of phosphoenergetic compounds and its potential issues in tumoral, metabolic and degenerative diseases. In the present paper, we report 1 year of experience and preliminary results for 40 patients as well as review of the literature. By successive in vivo determination and quantitation of numerous metabolites it allows, multinuclear spectroscopy may provide additional information to biomathematical models of brain metabolism.
authors.affiliation: Service de neuroradiologie, groupe hospitalier Pitié Salpêtrière, 47-83, boulevard de l'hôpital, 75651 Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Menuel
authors.forename: R
authors.initials: R
authors.lastname: Guillevin
authors.forename: R
authors.initials: R
authors.lastname: Costalat
authors.forename: M
authors.initials: M
authors.lastname: Perrin
authors.forename: M
authors.initials: M
authors.lastname: Sahli-Amor
authors.forename: N
authors.initials: N
authors.lastname: Martin-Duverneuil
authors.forename: J
authors.initials: J
authors.lastname: Chiras
mesh_terms: D001921:Brain / Q000378:metabolism*; D001927:Brain Diseases / Q000378:metabolism; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation / Q000379:methods*; D010759:Phosphorus Isotopes
chemical_list: D010759:Phosphorus Isotopes