title: Biologically functional cationic phospholipid-gold nanoplasmonic carriers of RNA.
abstract: Biologically functional cationic phospholipid-gold nanoplasmonic carriers have been designed to simultaneously exhibit carrier capabilities, demonstrate improved colloidal stability, and show no cytotoxicity under physiological conditions. Cargo, such as RNA, DNA, proteins, or drugs, can be adsorbed onto or incorporated into the cationic phospholipid bilayer membrane. These carriers are able to retain their unique nanoscale optical properties under physiological conditions, making them particularly useful in a wide range of imaging, therapeutic, and gene delivery applications that utilize selective nanoplasmonic properties.
authors.affiliation: Biomolecular Nanotechnology Center, Department of Bioengineering, University of California-Berkeley, UCSF/UCB Joint Graduate Group in Bioengineering, Berkeley, California 94720-1762, USA.
authors.forename: Somin Eunice
authors.initials: SE
authors.lastname: Lee
authors.forename: Darryl Y
authors.initials: DY
authors.lastname: Sasaki
authors.forename: Thomas D
authors.initials: TD
authors.lastname: Perroud
authors.forename: Daniel
authors.initials: D
authors.lastname: Yoo
authors.forename: Kamlesh D
authors.initials: KD
authors.lastname: Patel
authors.forename: Luke P
authors.initials: LP
authors.lastname: Lee
mesh_terms: D002412:Cations; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004337:Drug Carriers / Q000138:chemical synthesis*; D004355:Drug Stability; D018014:Gene Transfer Techniques; D006046:Gold / Q000737:chemistry*; D006801:Humans; D008027:Light; D008051:Lipid Bilayers / Q000737:chemistry*; D053768:Metal Nanoparticles; D010743:Phospholipids / Q000737:chemistry; D012313:RNA / Q000378:metabolism* / Q000494:pharmacology; D012542:Scattering, Radiation; D013501:Surface-Active Agents / Q000737:chemistry
chemical_list: D002412:Cations; D004337:Drug Carriers; D008051:Lipid Bilayers; D010743:Phospholipids; D013501:Surface-Active Agents; D012313:RNA; D006046:Gold