Bioactive guanidine alkaloids from two Caribbean marine sponges.
Seven new guanidine alkaloids (1-7) together with the known batzelladines A, F, H, and L, ptilomycalin A, and fromiamycalin were isolated from the Caribbean marine sponges Monanchora arbuscula and Clathria calla. Molecular structures were assigned on the basis of detailed analysis of 1D and 2D NMR spectra and mass spectrometry data, and bioactivities of the alkaloids were evaluated against human cancer cell lines and malaria protozoa.
Laville
Rémi
R
Institut de Chimie de Nice, LCMBA UMR 6001 CNRS, University of Nice-Sophia Antipolis, 28 Avenue de Valrose, Nice, France.
Thomas
Olivier P
OP
Berrué
Fabrice
F
Marquez
Diana
D
Vacelet
Jean
J
Amade
Philippe
P
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002738:Chloroquine / Q000494:pharmacology; D004351:Drug Resistance; D004354:Drug Screening Assays, Antitumor; D006146:Guanidines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010963:Plasmodium falciparum / Q000187:drug effects; D011161:Porifera / Q000737:chemistry
D000470:Alkaloids; D000962:Antimalarials; D000970:Antineoplastic Agents; D006146:Guanidines; D002738:Chloroquine