title: Temperature-dependent proteolysis as a control element in Escherichia coli metabolism.
abstract: Escherichia coli can grow at a broad temperature range, from less than 20 degrees C up to 45 degrees C. An increase in temperature results in a major physiological change, as enzymes work faster but, on the other hand, proteins tend to unfold. Therefore, a shift-up in temperature results in the induction of several regulatory response mechanisms aimed at restoring balanced growth at the new temperature. One important mechanism involves temperature-dependent proteolysis, which constitutes a fast response to temperature shift-ups. Here we discuss the effect of proteolysis on protein synthesis, and the heat shock response.
authors.affiliation: Department of Molecular Microbiology and Biotechnology, Faculty of Life Sciences, Tel Aviv University, Levanon St, Tel Aviv 69978, Israel.
authors.forename: Chen
authors.initials: C
authors.lastname: Katz
authors.forename: Aviram
authors.initials: A
authors.lastname: Rasouly
authors.forename: Eyal
authors.initials: E
authors.lastname: Gur
authors.forename: Yotam
authors.initials: Y
authors.lastname: Shenhar
authors.forename: Dvora
authors.initials: D
authors.lastname: Biran
authors.forename: Eliora Z
authors.initials: EZ
authors.lastname: Ron
mesh_terms: D049069:ATP-Dependent Proteases / Q000378:metabolism; D055162:Biocatalysis; D004926:Escherichia coli / Q000235:genetics / Q000254:growth & development / Q000378:metabolism*; D029968:Escherichia coli Proteins / Q000378:metabolism*; D015964:Gene Expression Regulation, Bacterial; D006360:Heat-Shock Proteins / Q000378:metabolism; D018869:Heat-Shock Response / Q000235:genetics; D008715:Methionine / Q000096:biosynthesis; D012808:Sigma Factor / Q000378:metabolism; D013312:Stress, Physiological; D013696:Temperature
chemical_list: D029968:Escherichia coli Proteins; D006360:Heat-Shock Proteins; D012808:Sigma Factor; C069774:heat-shock sigma factor 32; D008715:Methionine; D049069:ATP-Dependent Proteases; C513383:FtsH protein, E coli