Effect of opium on glucose metabolism and lipid profiles in rats with streptozotocin-induced diabetes.
BACKGROUND
This experimental study was performed to determine the impact of opium use on serum lipid profile and glucose metabolism in rats with streptozotocin-induced diabetes.


METHODS
To determine the effect of opium, 20 male rats were divided into control (n = 10) and opium-treated (n = 10) groups. After diabetes induction, the animals were investigated for daily glucose measurements for 35 days. Serum lipid profile and haemoglobin A1c (HbA(1c)) were assayed at the baseline (before induction of diabetes) and at 35-day follow-up.


RESULTS
The glycaemia levels in the rats treated with opium were similar to the levels measured in the control rats (544.8 +/- 62.2 mg/dl v. 524.6 +/- 50.0 mg/dl, P = 0.434). In addition, there was no difference between the opium-treated rats and control rats in HbA(1c) (6.5 +/- 0.5% v. 6.6 +/- 0.2%, P = 0.714). Compared to the control rats, the serum total cholesterol, high density lipoprotein (HDL), triglyceride and lipoprotein (a) in the test animals were similar.


CONCLUSIONS
Opium use has no significant effect on glucose metabolism and serum lipid profile in rats with induced diabetes.
Sadeghian
Saeed
S
Department of Cardiology, Tehran Heart Center, Terhan University of Medicine Medicine, Tehran, Iran. sadeghiantums@gmail.com
Boroumand
Mohammad Ali
MA
Sotoudeh-Anvari
Maryam
M
Rabbani
Shahram
S
Sheikhfathollahi
Mahmood
M
Abbasi
Ali
A
D000701:Analgesics, Opioid / Q000494:pharmacology*; D000704:Analysis of Variance; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D006442:Glycated Hemoglobin / Q000187:drug effects; D050356:Lipid Metabolism / Q000187:drug effects*; D008297:Male; D009892:Opium / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D000701:Analgesics, Opioid; D005947:Glucose; D006442:Glycated Hemoglobin; D009892:Opium; C517652:hemoglobin A1c protein, human