Dam and its role in pathogenicity of Salmonella enterica.
Dam methylation is an essential factor involved in the virulence of an increasing number of bacterial pathogens including Salmonella enterica. Lack of Dam methylation causes severe attenuation in animal models. It has been proposed that dysregulation of Dam activity is potentially a general strategy for the generation of vaccines against bacterial pathogens. In this review, we focus our attention on the role of methylation by Dam protein in regulating bacterial gene expression and virulence in Salmonella enterica.
Giacomodonato
Mónica N
MN
Centro de Estudios Farmacológicos y Botánicos CEFyBO-CONICET, Departamento de Microbiología, Parasitología e Inmunología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina. monicagiaco@gmail.com
Sarnacki
Sebastián H
SH
Llana
Mariángeles Noto
MN
Cerquetti
M Cristina
MC
D000818:Animals; D004195:Disease Models, Animal; D015964:Gene Expression Regulation, Bacterial; D008954:Models, Biological; D012481:Salmonella Infections, Animal / Q000382:microbiology; D022562:Salmonella Vaccines / Q000235:genetics / Q000276:immunology; D019779:Salmonella enterica / Q000166:cytology / Q000201:enzymology / Q000472:pathogenicity* / Q000502:physiology; D015265:Site-Specific DNA-Methyltransferase (Adenine-Specific) / Q000172:deficiency / Q000502:physiology*; D014613:Vaccines, Attenuated / Q000235:genetics / Q000276:immunology; D014774:Virulence; D037521:Virulence Factors / Q000172:deficiency / Q000502:physiology*
D022562:Salmonella Vaccines; D014613:Vaccines, Attenuated; D037521:Virulence Factors; C058693:Dam methyltransferase; D015265:Site-Specific DNA-Methyltransferase (Adenine-Specific)