title: [A case of severe asthma exacerbation complicated with cerebral edema and diffuse multiple cerebral micro-bleeds].
abstract: A 36-year-old woman was admitted to the Intensive Care Unit for the treatment of severe asthma exacerbation. Her condition of asthma improved with systemic glucocorticosteroids, inhaled beta2-agonist, intravenous theophylline and inhaled anesthesia (isoflurane) under mechanical ventilation. Her consciousness was disturbed even after terminating isoflurane. Brain CT and MRI scan showed cerebral edema and diffuse multiple cerebral micro-bleeds. Glyceol, a hyperosmotic diuretic solution consisting of 10% glycerol and 5% fructose in saline, was administered to decrease cerebral edema. Her consciousness disturbance gradually recovered. Cerebral edema and hemorrhage improved. On the 69th hospital day, she was discharged from hospital without sequelae. This case is a rare one in which severe asthma exacerbation was complicated with cerebral edema and diffuse multiple cerebral hemorrhage. Inhaled anesthesia for asthma exacerbation should be used carefully to avoid delay of diagnosis of central nervous system complications.
authors.affiliation: Respiratory Medicine, Kanazawa University Hospital.
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Ohkura
authors.forename: Masaki
authors.initials: M
authors.lastname: Fujimura
authors.forename: Asao
authors.initials: A
authors.lastname: Sakai
authors.forename: Kentaro
authors.initials: K
authors.lastname: Fujita
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Katayama
mesh_terms: D000328:Adult; D001249:Asthma / Q000150:complications*; D001929:Brain Edema / Q000209:etiology*; D002543:Cerebral Hemorrhage / Q000209:etiology*; D005260:Female; D006801:Humans