title: Eruptive postoperative squamous cell carcinomas exhibiting a pathergy-like reaction around surgical wound sites.
abstract: BACKGROUND
  The isomorphic response of Koebner and the pathergy skin reaction have not classically been associated with neoplastic processes such as cutaneous squamous cell carcinoma (SCC).
  
  
  OBJECTIVE
  We report 5 patients who developed postoperative eruptive SCCs within and around the healed or healing sites of excised nonmelanoma skin cancers. The original cancers were all excised with histologically tumor-free margins and the subsequent eruptive SCCs were sometimes multiple.
  
  
  METHODS
  We performed follow-up examinations of patient's wounds after the treatment of skin cancer with Mohs micrographic surgery. Keratotic nodules that developed acutely in the margins of healing wound sites of these patients were examined histologically by a single dermatopathologist.
  
  
  RESULTS
  The tumors presented as rapidly growing keratotic nodules within the sites of previously excised cancers. The mean time of clinical appearance was approximately 6 weeks and histologic examination of the nodules demonstrated well-differentiated SCC.
  
  
  CONCLUSIONS
  This study is limited by its relatively small number of cases.
  
  
  CONCLUSIONS
  Acutely eruptive SCC is a rare but significant postoperative complication of skin cancer surgery. Furthermore, this case series suggests that some individuals appear to be predisposed to this recurrent, pathergy-like reaction involving SCC.
authors.affiliation: Division of Dermatology, The Brody College of Medicine at East Carolina University, Greenville, North Carolina, USA.
authors.forename: Suleman J
authors.initials: SJ
authors.lastname: Bangash
authors.forename: W Harris
authors.initials: WH
authors.lastname: Green
authors.forename: David J
authors.initials: DJ
authors.lastname: Dolson
authors.forename: Armand B
authors.initials: AB
authors.lastname: Cognetta
mesh_terms: D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000473:pathology*; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology* / Q000601:surgery; D014945:Wound Healing