Prognostic factor of recurrence for resected digestive endocrine tumors.
OBJECTIVE
The aim of the present study was to identify the factors of recurrence for digestive endocrine tumours resected with curative intent.


METHODS
170 endocrine digestive tumours were reviewed from January 1997 to January 1997, Twenty eight patients were selected in this study. Localization of tumours were as follows: 14 duodenopancreatic (DP) and 14 Digestive (DT: 9 small bowel and 4 appendix). The following factors were investigated: primary site, hormonal clinical symptom, and differentiation.


RESULTS
Twenty eight patients (12 men) were selected. Median age was 48 (range, 23-79) yrs. All resection of metastasis were performed during the same procedure of primary tumour resection. There were 14 DT and 14 non functional DP tumours. For 28 patients, the only factor of recurrence was endocrine pancreatic tumour (p = 0.02). For non functional DP, the rate of recurrence was significantly dependent on histology and the expression of ki67 antigen and presence of metastasis. Survival free of disease for DT were: 100%,80% at 1, 5 yrs, and for DP they were 93%, 50%, 33% at 1, 3, 5 yrs, respectively.


CONCLUSIONS
The expression of the Ki67 antigen and differentiation seem to be good indicators for DP recurrence and may need an adjuvant treatment despite the R0 resection.
Ouaïssi
Mehdi
M
Service de Chirurgie Générale et Digestive, Hôpital Ambroise Paré, Paris, France. mehdi.ouaissi@mail.ap-hm.fr
Julié
Catherine
C
Mitry
Emmanuel
E
Sielezneff
Igor
I
Jimenez
Patricia
P
Loundou
Anderson
A
Benoist
Stéphane
S
Penna
Christophe
C
Franc
Brigitte
B
Rougier
Philippe
P
Nordlinger
Bernard
B
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016009:Chi-Square Distribution; D004701:Endocrine Gland Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011237:Predictive Value of Tests; D011379:Prognosis; D012307:Risk Factors; D018709:Statistics, Nonparametric