title: Chemical composition and antibacterial activity of the essential oil of Cordia verbenacea from the Venezuelan Andes.
abstract: The essential oil of Cordia verbenacea D.C. (Boraginaceae) that grows in Mérida-Venezuela was obtained by hydrodistillation from the aerial parts of the plant, yielding 0.21%. The oil was analyzed by GC-FID and GC-MS. Thirty one components which made up 94.3% of the oil were identified. The most abundant constituents found were: tricyclene (23.9%), bicyclogermacrene (11.7%), germacrene D (9.9%) and beta-caryophyllene (8.2%). Antibacterial activity determination was carried out according to the disc diffusion assay. Activity against Gram-positive bacteria Staphylococcus aureus ATCC 6538 and Enterococcus faecalis ATCC 29212, at a minimal inhibitory concentration (MIC) of 170 microg/mL and 200 microg/mL, was found.
authors.affiliation: Research Institute, Faculty of Pharmacy and Bioanalysis, University of Los Andes, Mérida, Venezuela. gmeccia@ula.ve
authors.forename: Gina
authors.initials: G
authors.lastname: Meccia
authors.forename: Luis B
authors.initials: LB
authors.lastname: Rojas
authors.forename: Judith
authors.initials: J
authors.lastname: Velasco
authors.forename: Tulia
authors.initials: T
authors.lastname: Díaz
authors.forename: Alfredo
authors.initials: A
authors.lastname: Usubillaga
authors.forename: Juan Carmona
authors.initials: JC
authors.lastname: Arzola
authors.forename: Sulymar
authors.initials: S
authors.lastname: Ramos
mesh_terms: D000531:Altitude; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002849:Chromatography, Gas / Q000379:methods; D031213:Cordia / Q000737:chemistry*; D017753:Ecosystem; D013293:Enterococcus faecalis / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D007711:Klebsiella pneumoniae / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D009822:Oils, Volatile / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D018514:Plant Structures / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects; D014687:Venezuela
chemical_list: D000900:Anti-Bacterial Agents; D009822:Oils, Volatile