title: Development of new DNA triplex triads by using 5-substituted deoxycytidine.
abstract: We developed a new artificial DNA triplex triad which has the adenine nucleobase in the first strand. This triplex triad (A-psi-C*) is composed of adenine, pseudouridine and 5-sudstituted cytosine as the 1st, 2nd and 3rd strand nucleobases, respectively. The molecular design and synthesis of the nucleobases for the 2nd and 3rd strand of the triplex are also described.
authors.affiliation: Department of Life Science, Tokyo Institute of Technology, Yokohama 226-8501, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Kanamori
authors.forename: Hirosuke
authors.initials: H
authors.lastname: Tsunoda
authors.forename: Akihiro
authors.initials: A
authors.lastname: Ohkubo
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Sekine
authors.forename: Kohji
authors.initials: K
authors.lastname: Seio
mesh_terms: D004247:DNA / Q000737:chemistry*; D003841:Deoxycytidine / Q000737:chemistry*; D009691:Nucleic Acid Denaturation
chemical_list: C051802:triplex DNA; D003841:Deoxycytidine; D004247:DNA