title: Immune responses following one and two doses of the reformulated, bivalent, killed, whole-cell, oral cholera vaccine among adults and children in Kolkata, India: a randomized, placebo-controlled trial.
abstract: Immune responses after one and two doses of the reformulated killed oral cholera vaccine were measured in a double-blind, randomized, placebo-controlled trial of 77 adults aged 18-40 years and 77 children aged 1-17 years residing in Kolkata, India. 65% of adults and 87% of children and 46% of adults and 82% of children exhibited a > or =4-fold rise in serum Vibrio cholerae O1 vibriocidal antibody titers from baseline following dose 1 and 2, respectively. Responses to V. cholerae O139 were less pronounced but followed a similar pattern. We demonstrate that in a cholera-endemic area, the vaccine elicited vibriocidal responses after a single-dose of the vaccine.
authors.affiliation: National Institute of Cholera and Enteric Diseases, Kolkata, India.
authors.forename: Suman
authors.initials: S
authors.lastname: Kanungo
authors.forename: Allison
authors.initials: A
authors.lastname: Paisley
authors.forename: Anna Lena
authors.initials: AL
authors.lastname: Lopez
authors.forename: Mihir
authors.initials: M
authors.lastname: Bhattacharya
authors.forename: Byomkesh
authors.initials: B
authors.lastname: Manna
authors.forename: Deok Ryun
authors.initials: DR
authors.lastname: Kim
authors.forename: Seung Hyun
authors.initials: SH
authors.lastname: Han
authors.forename: Stephen
authors.initials: S
authors.lastname: Attridge
authors.forename: Rodney
authors.initials: R
authors.lastname: Carbis
authors.forename: Raman
authors.initials: R
authors.lastname: Rao
authors.forename: Jan
authors.initials: J
authors.lastname: Holmgren
authors.forename: John D
authors.initials: JD
authors.lastname: Clemens
authors.forename: Dipika
authors.initials: D
authors.lastname: Sur
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood*; D000917:Antibody Formation; D002648:Child; D002675:Child, Preschool; D002771:Cholera / Q000276:immunology / Q000517:prevention & control*; D022121:Cholera Vaccines / Q000276:immunology*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007117:Immunization, Secondary; D007194:India; D007223:Infant; D008297:Male; D015164:Vaccines, Inactivated / Q000276:immunology; D055815:Young Adult
chemical_list: D000907:Antibodies, Bacterial; D022121:Cholera Vaccines; D015164:Vaccines, Inactivated