title: Clinical features of patients with typhoid fever and drug resistance of the causative isolates in western Iran.
abstract: Typhoid fever is an important infectious disease in developing countries, including Iran. In this survey, all patients hospitalized in teaching hospitals of Hamedan during 1995-2005 were investigated. A total of 162 patients with typhoid fever were studied. Of all patients, 106 were male (65.4%). The most prevalent symptoms were fever (93.2%), chills (76.5%), anorexia (72.2%) and headache (71%). Splenomegaly and hepatomegaly were present in 43.8% and 13.6%, respectively. Salmonella typhi strains were identified in 144 patients (88.9%) and S. paratyphi A strains were found in 12 (7.4%). In others, S. paratyphi B and C were detected. Serum glutamic oxalo-acetic transaminase values were higher than normal in 77.5% of cases and serum glutamic pyruvic transaminase values were higher than normal in 62.5%. The highest sensitivity rate was for ceftizoxime, 91.4% and the lowest rate was for ampicillin, 16.3%.
authors.affiliation: Department of Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran. mitraranjbar@yahoo.com
authors.forename: Ranjbar
authors.initials: R
authors.lastname: Mitra
authors.forename: Mohammad Alizadeh Amir
authors.initials: MA
authors.lastname: Houshang
authors.forename: Hashemi Seyed
authors.initials: HS
authors.lastname: Hamid
authors.forename: Dadashpoor
authors.initials: D
authors.lastname: Maryam
authors.forename: Madrakian Ali
authors.initials: MA
authors.lastname: Reza
authors.forename: Hadidchi
authors.initials: H
authors.lastname: Shima
authors.forename: Nojomi
authors.initials: N
authors.lastname: Marzieh
mesh_terms: D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002648:Child; D024881:Drug Resistance, Bacterial; D005260:Female; D006801:Humans; D007492:Iran; D008297:Male; D014435:Typhoid Fever / Q000175:diagnosis* / Q000188:drug therapy*; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents