Effects of endothelial nitric oxide synthase, interleukin-6 gene polymorphisms and asymmetric dimethylarginine levels on risk factors and lesion sites in peripheral artery disease.
This study investigated risk factors for atherosclerosis and their relationship with lesion sites. Patients (n = 160) with peripheral artery disease (PAD) completed a questionnaire regarding risk factors for PAD. Endothelial nitric oxide synthase (eNOS) and interleukin (IL)-6 gene polymorphisms and asymmetric dimethylarginine (ADMA) levels were measured. Patients with coronary artery disease had significantly higher ratios of eNOS T/C and C/C genotypes, which include the C allele, than the T/T genotype. The IL-6 gene polymorphism distribution ratios for patients with over four risk factors were significantly different compared with other patients, with a higher rate of the C/C genotype. ADMA levels did not show any significant relationship to risk factors or polymorphism. Levels were, however, slightly higher in femoral lesion sites. The results support a model in which the C/C genotype of eNOS and IL-6 gene polymorphisms promote PAD development. The eNOS C/C genotype may have an independent effect, whereas the effects of the IL-6 C/C genotype are seen in conjunction with other risk factors.
Tuygun
A K
AK
Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey. aktuygun@gmail.com
Keser
M
M
Tuygun
A
A
Ketenci
B
B
Sensöz
Y
Y
Balci
A Y
AY
Karaci
A R
AR
Kizilay
M
M
Yurtseven
N
N
Yekeler
I
I
D001120:Arginine / Q000031:analogs & derivatives / Q000097:blood; D004252:DNA Mutational Analysis; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D008957:Models, Genetic; D052250:Nitric Oxide Synthase Type III / Q000235:genetics* / Q000378:metabolism; D016491:Peripheral Vascular Diseases / Q000097:blood / Q000235:genetics* / Q000473:pathology; D011110:Polymorphism, Genetic; D012307:Risk Factors; D011795:Surveys and Questionnaires
C508600:IL6 protein, human; D015850:Interleukin-6; C487735:dimethylarginine; D001120:Arginine; D052250:Nitric Oxide Synthase Type III