The 'stem cell' concept: is it holding us back?
Developmental biology, regenerative medicine and cancer biology are increasingly occupied with the molecular characterization of stem cells. Yet recent work adds to a growing body of literature suggesting that 'stemness' cannot be reduced to the molecular features of cell types, and is instead an emergent property of cell lineages under feedback control.
Lander
Arthur D
AD
Center for Complex Biological Systems, Department of Developmental and Cell Biology, and Department of Biomedical Engineering, University of California at Irvine, Irvine, CA 92697-2300, USA. adlander@uci.edu
D000818:Animals; D002454:Cell Differentiation; D019070:Cell Lineage; D049109:Cell Proliferation; D015509:Developmental Biology; D004777:Environment; D025461:Feedback, Physiological; D006801:Humans; D044968:Regenerative Medicine; D013234:Stem Cells / Q000166:cytology* / Q000502:physiology; D009626:Terminology as Topic