Studies on anti-inflammatory, antipyretic and analgesic properties of Caesalpinia bonducella F. seed oil in experimental animal models.
Caesalpinia bonducella FLEMING (Caesalpiniaceae) plant is well known for its medicinal and therapeutic values in Indian Ayurveda. However, to be clinically useful, more scientific data are needed. Therefore, in the present study, we investigated the effects of C. bonducella seed oil on acute and chronic inflammation. To assess the anti-inflammatory, antipyretic and analgesic activities, varied concentrations of the seed oil of C. bonducella (100, 200 and 400mg/kg orally) were tested in carrageenan-induced rat paw oedema, brewer's yeast-induced pyrexia, acetic acid-induced writhing and hot plate reaction time in experimental rats. The paw volumes, pyrexia and writhes in experimental rats were reduced significantly (p<0.05) as compared to that of control, and hot plate test showed significant licking effect in rats. These results clearly indicate that the oil of C. bonducella seeds could be a potential source for using as anti-inflammatory, antipyretic and analgesic agent.
Shukla
Shruti
S
Faculty of Life Sciences, Department of Botany, Dr HS Gour University, Sagar 470003, Madhya Pradesh, India. s.microb@yahoo.com
Mehta
Archana
A
Mehta
Pradeep
P
Vyas
Suresh Prasad
SP
Shukla
Savita
S
Bajpai
Vivek K
VK
D019342:Acetic Acid; D018712:Analgesics, Non-Narcotic; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001522:Behavior, Animal / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D029911:Caesalpinia / Q000737:chemistry*; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D005260:Female; D005528:Foot / Q000473:pathology; D006614:Hindlimb / Q000473:pathology; D008297:Male; D010147:Pain Measurement / Q000187:drug effects; D010938:Plant Oils / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D011930:Reaction Time / Q000187:drug effects; D012441:Saccharomyces cerevisiae; D012639:Seeds / Q000737:chemistry
D018712:Analgesics, Non-Narcotic; D000894:Anti-Inflammatory Agents, Non-Steroidal; D010938:Plant Oils; D002351:Carrageenan; D019342:Acetic Acid