Aggressive subcutaneous panniculitis-like T-cell lymphoma with hemophagocytosis in two children (subcutaneous panniculitis-like T-cell lymphoma).
Subcutaneous panniculitis-like T-cell lymphoma is an uncommon form of cutaneous lymphoma in the pediatric population. It is characterized histologically by subcutaneous infiltration of pleomorphic cytotoxic T cells, mimicking a lobular panniculitis. Although usually described as having an indolent clinical course, the condition may be complicated by systemic involvement and hemophagocytic syndrome, resulting in a poorer prognosis. We present two pediatric patients with aggressive forms of subcutaneous panniculitis-like T-cell lymphoma complicated by hemophagocytic syndrome, and discuss the current literature.
Koh
Mark Jean-Aan
MJ
Department of Dermatology, Changi General Hospital, Singapore. docmark@pacific.net.sg
Sadarangani
Sapna P
SP
Chan
Yuin-Chew
YC
Chan
Mei-Yoke
MY
Tan
Ah-Moy
AM
Tan
Suat-Hoon
SH
Tay
Yong-Kwang
YK
Ng
Siok-Bian
SB
D002648:Child; D005260:Female; D006801:Humans; D007223:Infant; D051359:Lymphohistiocytosis, Hemophagocytic / Q000209:etiology* / Q000473:pathology; D016399:Lymphoma, T-Cell / Q000150:complications* / Q000473:pathology; D008297:Male; D015434:Panniculitis / Q000209:etiology* / Q000473:pathology; D012720:Severity of Illness Index; D012878:Skin Neoplasms / Q000150:complications* / Q000473:pathology; D050151:Subcutaneous Fat / Q000473:pathology