title: Association between androgens, intima-media thickness and the metabolic syndrome in obese adolescent girls.
abstract: BACKGROUND
  While an association between androgens and the metabolic syndrome (MS) is well established in obese women, studies concerning this relationship are scarce in obese adolescent girls. Therefore, we analysed the relationships between androgens, MS and intima-media thickness (IMT) in this age-group.
  
  
  METHODS
  In 160 obese girls (aged 12-18 years, mean BMI: 32.6 +/- 5.0 kg/m((2))), androgens [testosterone, dehydroepiandrosterone sulphate (DHEA-S), androstenedione], SHBG and the components of MS (waist circumference, blood pressure (BP), lipids, uric acid, insulin, glucose, 2 h glucose in oral glucose tolerance test (oGTT)) were studied. Furthermore, IMT was determined in a subgroup of 71 randomly chosen girls.
  
  
  RESULTS
  Testosterone correlated significantly to systolic BP (r = 0.20), diastolic BP (r = 0.24), 2 h glucose in oGTT (r = 0.30), triglycerides (r = 0.19), uric acid (r = 0.17), waist circumference (r = 0.25) and IMT (r = 0.54). These relationships (except for waist circumference and uric acid) were independent of BMI and insulin resistance index homeostasis model assessment. In contrast to testosterone, DHEA-S, androstenedione and SHBG showed no or weaker correlations to any parameter of MS. The 48 girls with MS demonstrated significantly higher testosterone (1.8 +/- 0.7 nmol/l; P = 0.025) and DHEA-S (4.7 +/- 2.3 micromol/l; P = 0.008) concentrations as compared with the 112 girls without MS (mean testosterone 1.5 +/- 0.7 nmol/l, mean DHEA-S 3.6 +/- 2.3 micromol/l).
  
  
  CONCLUSIONS
  Testosterone was significantly related to MS and its components in obese adolescent girls independently of BMI and insulin resistance. As IMT was significantly associated with testosterone, this supports the clinical relevance of this finding.
authors.affiliation: Institute of Paediatric Nutrition Medicine, Vestische Hospital for Children and Adolescents, University of Witten/Herdecke, Witten.
authors.forename: Gideon
authors.initials: G
authors.lastname: de Sousa
authors.forename: Christian
authors.initials: C
authors.lastname: Brodoswki
authors.forename: Michaela
authors.initials: M
authors.lastname: Kleber
authors.forename: Rainer
authors.initials: R
authors.lastname: Wunsch
authors.forename: Thomas
authors.initials: T
authors.lastname: Reinehr
mesh_terms: D000293:Adolescent; D000728:Androgens / Q000097:blood*; D001794:Blood Pressure / Q000502:physiology; D015992:Body Mass Index; D002648:Child; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D024821:Metabolic Syndrome / Q000097:blood* / Q000453:epidemiology / Q000473:pathology* / Q000503:physiopathology; D009765:Obesity / Q000097:blood* / Q000453:epidemiology / Q000473:pathology* / Q000503:physiopathology; D009929:Organ Size; D013223:Statistics as Topic; D013739:Testosterone / Q000097:blood; D017539:Tunica Intima / Q000473:pathology*; D017540:Tunica Media / Q000473:pathology
chemical_list: D000728:Androgens; D013739:Testosterone