Selective suppression of hippocampal ripples impairs spatial memory.
Sharp wave-ripple (SPW-R) complexes in the hippocampus-entorhinal cortex are believed to be important for transferring labile memories from the hippocampus to the neocortex for long-term storage. We found that selective elimination of SPW-Rs during post-training consolidation periods resulted in performance impairment in rats trained on a hippocampus-dependent spatial memory task. Our results provide evidence for a prominent role of hippocampal SPW-Rs in memory consolidation.
Girardeau
Gabrielle
G
Laboratoire de Physiologie de la Perception et de l'Action, Collège de France, CNRS, Paris, France.
Benchenane
Karim
K
Wiener
Sidney I
SI
Buzsáki
György
G
Zugaro
Michaël B
MB
D000200:Action Potentials / Q000502:physiology; D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal; D001703:Biophysics; D004558:Electric Stimulation / Q000379:methods; D004569:Electroencephalography / Q000379:methods; D005071:Evoked Potentials / Q000502:physiology*; D006624:Hippocampus / Q000166:cytology / Q000502:physiology*; D008297:Male; D018782:Maze Learning / Q000502:physiology; D008569:Memory Disorders / Q000503:physiopathology*; D009415:Nerve Net / Q000502:physiology; D009433:Neural Inhibition / Q000502:physiology*; D009474:Neurons / Q000502:physiology; D009862:Online Systems; D051381:Rats; D020318:Rats, Long-Evans; D013028:Space Perception / Q000502:physiology*; D013057:Spectrum Analysis / Q000379:methods