title: Lipid profile in patients with psoriasis presenting at Liaquat University Hospital Hyderabad.
abstract: OBJECTIVE
  To determine the lipid abnormalities in patients with psoriasis and compare it with healthy controls.
  
  
  METHODS
  Across-sectional controlled study was conducted at the Department of Dermatology Liaquat University Hospital Hyderabad from January 2007 to November 2007. The study included 158 consecutive patients; among which 88 were males (44 patients and 44 controls) and 70 females (35 patients and 35 controls). The patients with psoriasis having less than 30% body involvement were included in the study. Patients with severe psoriasis, high BMI (.30 kg/m2), hypertension, diabetes, smoking, alcohol consumption and personal or family history of hyperlipedemia were excluded. The patients were examined clinically and findings recorded on a pre-designed proforma. Fasting lipids were measured using SELECTRA XL chemistry analyzer using Spin react kits (made in Spain) by direct method.
  
  
  RESULTS
  All patients had psoriasis involving less than 30% of body surface. Their ages ranged from 18 years to 68 years (mean 37 +/- 7.96 years). Family history of disease was positive in 10 (6.32%) patients. 134 (84.8%) had plaque type psoriasis, 10 (6%) had in addition scalp and nail involvement, 05 (3.16%) guttate lesions, 05 (3.16%) had palmoplantar lesions while remaining 04 (2.43%) comprised of hyperkeratotic and flexural psoriasis. The duration of disease ranged between 18 months to 10 years with a mean of 4.5 +/- 1.89 years. Serum cholesterol, triglycerides and low density lipoprotein (LDL) cholesterol were significantly higher than in the normal control group (P < 0.01). There was no significant statistical difference in serum levels of very low density lipoprotein cholesterol (VLDL) and high density lipoprotein cholesterol (HDL-C) between the two groups.
  
  
  CONCLUSIONS
  Psoriasis is an independent risk factor for hyperlipidaemia and its possible subsequent sequelae such as obstructive vascular disease.
authors.affiliation: Department of Dermatology, Liaquat University of Medical & Health Sciences, Jamshoro, Hyderabad.
authors.forename: Doulat Rai
authors.initials: DR
authors.lastname: Bajaj
authors.forename: Shah Muhammad
authors.initials: SM
authors.lastname: Mahesar
authors.forename: Bekha Ram
authors.initials: BR
authors.lastname: Devrajani
authors.forename: Muhammad Pervaiz
authors.initials: MP
authors.lastname: Iqbal
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015992:Body Mass Index; D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D015243:Cholesterol, VLDL / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D006785:Hospitals, University; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000453:epidemiology*; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010154:Pakistan / Q000453:epidemiology; D011565:Psoriasis / Q000097:blood* / Q000453:epidemiology; D012307:Risk Factors; D012720:Severity of Illness Index; D012737:Sex Factors; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D015243:Cholesterol, VLDL; D008055:Lipids; D014280:Triglycerides