Predicting age-specific dosing of antipsychotics.
Antipsychotic medications are the standard of care for both acute and maintenance treatment of schizophrenia, the latter requiring an indefinite treatment across a patient's life span. However, dosing and tolerability of antipsychotics have been studied primarily in younger patients, and very limited data are available for age- and phase-specific dosing. This leaves the clinician with no guidance on dose adjustment as patients grow older-an issue of critical importance, especially in light of recent concerns about increased morbidity and mortality associated with antipsychotics.
Uchida
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H
Centre for Addiction and Mental Health, Geriatric Mental Health Program, Ontario, Canada.
Pollock
B G
BG
Bies
R R
RR
Mamo
D C
DC
D000375:Aging; D014150:Antipsychotic Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D001480:Basal Ganglia Diseases / Q000139:chemically induced; D004305:Dose-Response Relationship, Drug; D006801:Humans; D049268:Positron-Emission Tomography; D011954:Receptors, Dopamine / Q000378:metabolism; D012559:Schizophrenia / Q000000981:diagnostic imaging / Q000188:drug therapy*
D014150:Antipsychotic Agents; D011954:Receptors, Dopamine