title: Cellular consequences of inositol depletion.
abstract: The inositol-depletion hypothesis was suggested to explain the therapeutic mechanism of mood-stabilizing drugs. Focus was previously on the phosphatidylinositol signalling pathway and on the regulatory roles of Ins(3,4,5)P(3) and DAG (diacylglycerol). Recent findings indicate that inositol and inositol-containing molecules, including phosphoinositides and inositol phosphates, have signalling and regulatory roles in many cellular processes. This suggests that depleting inositol may lead to perturbation of a wide range of cellular functions, at least some of which may be associated with bipolar disorder.
authors.affiliation: Department of Biological Sciences, Wayne State University, Detroit, MI 48202, USA.
authors.forename: Rania M
authors.initials: RM
authors.lastname: Deranieh
authors.forename: Miriam L
authors.initials: ML
authors.lastname: Greenberg
mesh_terms: D001714:Bipolar Disorder / Q000188:drug therapy* / Q000378:metabolism* / Q000503:physiopathology; D004075:Diglycerides / Q000378:metabolism; D038362:Glycogen Synthase Kinase 3 / Q000378:metabolism; D006801:Humans; D007294:Inositol / Q000378:metabolism*; D007295:Inositol Phosphates / Q000378:metabolism; D018020:Lithium Compounds / Q000627:therapeutic use*; D008928:Mitochondria / Q000378:metabolism; D010716:Phosphatidylinositols / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology
chemical_list: D004075:Diglycerides; D007295:Inositol Phosphates; D018020:Lithium Compounds; D010716:Phosphatidylinositols; D007294:Inositol; D038362:Glycogen Synthase Kinase 3