Pepsinogen I concentration in organic dyspepsia patients at Gastroenterology Division, Department of Internal Medicine, Cipto Mangunkusumo Hospital.
OBJECTIVE
To study Pepsinogen I (PG I) concentration in atrophic chronic gastritis (ACG) and non-atrophic chronic gastritis (NACG) patients with or without H. pylori infection compared to gastroscopy and biopsy as the gold standard.


METHODS
The study subjects consisted of 70 organic dyspepsia patients who underwent esofago gastroduodenoscopy (EGD) at the Gastroenterology Outpatient Clinic Department of Internal Medicine Cipto Mangunkusumo Hospital. Pepsinogen I tests were performed using ELISA with Human Pepsinogen I ELISA kit from Biohit. The data analysis used the SPSS 13 program. The ROC curve was used to find the cut off point with the best sensitivity and specificity. The proportion of positive H. Pylori was measured in percentage.


RESULTS
From the 70 organic dyspepsia patients, there were 37 subjects (52.8%) that have histopathological findings of NACG and 26 subjects (37.1%) ACG. The best cut off point for PG I concentration to predict ACG is 119 microg/L (sensitivity 70%, specificity 50%). The value of PG I concentrations between NACG and ACG patients did not differ significantly at 0.485 (p > 0.05).


CONCLUSIONS
The cut off point for PG I concentrations in this study did not differ significantly between NACG and ACG patients.
Aulia
Diana
D
Department of Clinical Pathology, Faculty of Medicine University of Indonesia - dr. Cipto Mangunkusumo Hospital, Jakarta Pusat 10430, Indonesia. diana.aulia@gmail.com
Manz
Gaby Octavia
GO
Simadibrata
Marcellus
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood*; D001706:Biopsy; D003937:Diagnosis, Differential; D004415:Dyspepsia / Q000097:blood* / Q000175:diagnosis; D016099:Endoscopy, Gastrointestinal; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D006785:Hospitals, University; D006801:Humans; D008297:Male; D008875:Middle Aged; D020116:Pepsinogen A / Q000097:blood*; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D055815:Young Adult
D015415:Biomarkers; D020116:Pepsinogen A