Design and synthesis of the novel cross-linking agent.
Previously, we have developed a highly efficient and selective cross-linking reaction to the cytosine base at the target site of DNA using the oligodeoxynucleotide (ODN) containing 2-amino-6-vinylpurine derivative (1). Based on these results, we have designed the novel cross-linking agents, which are pyrimidine derivatives having two hydrogen bond sites and vinyl group as a reactive moiety. In this paper, we wish to report the results to investigate on the synthesis of the pyrimidine derivatives having potential as novel cross-linking agents.
Kusano
Shuhei
S
Institute of Multidisciplinary Research for Advanced Materials Tohoku University, Sendai 980-8587, Japan.
Hattori
Keiichi
K
Imoto
Shuhei
S
Nagatsugi
Fumi
F
D003432:Cross-Linking Reagents / Q000138:chemical synthesis* / Q000737:chemistry; D009838:Oligodeoxyribonucleotides / Q000737:chemistry; D011687:Purines / Q000737:chemistry; D011742:Pyrimidine Nucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D014753:Vinyl Compounds / Q000737:chemistry
C432203:2-amino-6-vinylpurine; D003432:Cross-Linking Reagents; D009838:Oligodeoxyribonucleotides; D011687:Purines; D011742:Pyrimidine Nucleotides; D014753:Vinyl Compounds