title: Risk factors for respiratory failure associated with respiratory syncytial virus infection in adults.
abstract: Risk factors associated with respiratory failure during respiratory syncytial virus (RSV) infection have not been assessed in adults. We identified RSV by quantitative reverse transcription polymerase chain reaction in 58 adults during the 2007-2008 winter. Clinical variables and respiratory secretion viral loads were compared in 26 outpatients and 32 inpatients. Cardiopulmonary diseases were more common among inpatients than outpatients (91% vs 31%, P = .0001), whereas mean RSV load was similar. Nasal viral load was higher in ventilated vs nonventilated hospitalized patients (log(10) 3.7 +/- 1.7 plaque-forming units (PFUs)/mL vs 2.4 +/- 1.1 PFUs/mL, P = .02), and high viral load was independently associated with respiratory failure.
authors.affiliation: Department of Medicine, Rochester General Hospital, Rochester, New York 14621-3001, USA.
authors.forename: Coley B
authors.initials: CB
authors.lastname: Duncan
authors.forename: Edward E
authors.initials: EE
authors.lastname: Walsh
authors.forename: Derick R
authors.initials: DR
authors.lastname: Peterson
authors.forename: F Eun-Hyung
authors.initials: FE
authors.lastname: Lee
authors.forename: Ann R
authors.initials: AR
authors.lastname: Falsey
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006331:Heart Diseases / Q000150:complications; D006801:Humans; D007297:Inpatients; D016015:Logistic Models; D008171:Lung Diseases / Q000150:complications; D008297:Male; D008875:Middle Aged; D010045:Outpatients; D012131:Respiratory Insufficiency / Q000150:complications*; D018357:Respiratory Syncytial Virus Infections / Q000150:complications*; D012307:Risk Factors; D019562:Viral Load