Naturally occurring labdane diterpene and benzofuran from Globba pendula.
Phytochemical investigation on Globba pendula resulted in the isolation of a new naturally occurring 16-oxo-(8)17-12-labdadien-15,11-olide 1 and benzofuran-2-carboxaldehyde 2. Other known compounds including isoandrographolide, indirubin, vanillin, vanillic acid, 2(3H)-benzoxazolone, as well as beta-sitosteryl-beta-D-glucopyranoside, beta-sitosterol, and 7alpha-hydroxysitosterol were also isolated. The structures were established based on spectroscopic data and comparison with the literature. Furthermore, the compound isoandrographolide has demonstrated strong cytotoxic properties towards a panel of cancer cell lines (MCF-7, PC-3, and H-460) with the IC50 values of 7.9, 8.7, and 9.0 microM, respectively.
Maulidiani
Institute of Bioscience, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia.
Shaari
Khozirah
K
Paetz
Christian
C
Stanslas
Johnson
J
Abas
Faridah
F
Lajis
Nordin Haji
NH
D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D019684:Magnoliopsida / Q000737:chemistry* / Q000187:drug effects; D008296:Malaysia; D018515:Plant Leaves / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared
D001572:Benzofurans; D004224:Diterpenes