Parallel chemoenzymatic synthesis of sialosides containing a C5-diversified sialic acid.
A convenient chemoenzymatic strategy for synthesizing sialosides containing a C5-diversified sialic acid was developed. The alpha2,3- and alpha2,6-linked sialosides containing a 5-azido neuraminic acid synthesized by a highly efficient one-pot three-enzyme approach were converted to C5''-amino sialosides, which were used as common intermediates for chemical parallel synthesis to quickly generate a series of sialosides containing various sialic acid forms.
Cao
Hongzhi
H
Department of Chemistry, University of California-Davis, One Shields Avenue, Davis, CA 95616, USA.
Muthana
Saddam
S
Li
Yanhong
Y
Cheng
Jiansong
J
Chen
Xi
X
D055162:Biocatalysis; D006027:Glycosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D019158:N-Acetylneuraminic Acid / Q000737:chemistry*; D000216:N-Acylneuraminate Cytidylyltransferase / Q000737:chemistry / Q000378:metabolism; D007652:Oxo-Acid-Lyases / Q000737:chemistry / Q000378:metabolism; D012799:Sialyltransferases / Q000737:chemistry / Q000378:metabolism
D006027:Glycosides; D012799:Sialyltransferases; D000216:N-Acylneuraminate Cytidylyltransferase; D007652:Oxo-Acid-Lyases; C018728:N-acetylneuraminate lyase; D019158:N-Acetylneuraminic Acid