Japonicones E-L, dimeric sesquiterpene lactones from Inula japonica Thunb.
Eight new dimeric sesquiterpene lactones (japonicones E-L, 1- 8), including a novel sesquiterpene dimer bearing a rare hydroperoxide group (japonicone E, 1), were isolated from the aerial part of Inula japonica Thunb. Their structures were determined mainly by the use of 1D and 2D NMR spectroscopic techniques including HSQC, (1)H-(1)H COSY, HMBC, and NOESY. All the isolates were tested for inhibitory effects against LPS-induced NO production in RAW264.7 macrophages. Among the compounds tested, japonicone F (2) showed the strongest activity with the IC(50) value of 4.1 microg/mL.
Qin
Jiang Jiang
JJ
School of Pharmacy, Shanghai Jiao Tong University, Shanghai, PR China.
Jin
Hui Zi
HZ
Zhu
Jia Xian
JX
Fu
Jian Jun
JJ
Hu
Xiao Jia
XJ
Liu
Xiao Hua
XH
Zhu
Yan
Y
Yan
Shi Kai
SK
Zhang
Wei Dong
WD
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006861:Hydrogen Peroxide; D020128:Inhibitory Concentration 50; D038143:Inula / Q000737:chemistry*; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008070:Lipopolysaccharides; D008264:Macrophages / Q000187:drug effects*; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000096:biosynthesis*; D035261:Plant Components, Aerial; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
D000893:Anti-Inflammatory Agents; D007783:Lactones; D008070:Lipopolysaccharides; D012717:Sesquiterpenes; C549908:japonicone E; C549909:japonicone L; D009569:Nitric Oxide; D006861:Hydrogen Peroxide