title: Synthesis and properties of oligodeoxynucleotides containing biaryl units.
abstract: We describe the synthesis and properties of oligonucleotides (ONs) containing biaryl units, which are composed of a bis(hydroxymethyl)benzene residue and a naphthalene or pyrene moiety. We found that by introducing the biaryl units into the ONs, the aromatic chromophores are suitably arrayed in the DNAs. Further, we succeeded in the detection of a single-base mismatch in RNA by using the ON containing the biaryl unit as a molecular beacon.
authors.affiliation: Department of Biomolecular Science, Faculty of Engineering, Gifu University, United Graduate School of Drug Discovery and Medical Information Sciences, Gifu 501-1193, Japan. uenoy@gifu-u.ac.jp
authors.forename: Yoshihito
authors.initials: Y
authors.lastname: Ueno
authors.forename: Shinji
authors.initials: S
authors.lastname: Komatsuzaki
authors.forename: Keiji
authors.initials: K
authors.lastname: Takasu
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Kitamura
authors.forename: Yukio
authors.initials: Y
authors.lastname: Kitade
mesh_terms: D001592:Benzyl Alcohols / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry*; D009281:Naphthalenes / Q000737:chemistry*; D009691:Nucleic Acid Denaturation; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis / Q000737:chemistry*; D011721:Pyrenes / Q000737:chemistry*; D012333:RNA, Messenger / Q000737:chemistry; D013050:Spectrometry, Fluorescence
chemical_list: D001592:Benzyl Alcohols; D005456:Fluorescent Dyes; D009281:Naphthalenes; D009838:Oligodeoxyribonucleotides; D011721:Pyrenes; D012333:RNA, Messenger