title: Chloroquine administration does not prevent Nipah virus infection and disease in ferrets.
abstract: Hendra virus and Nipah virus, two zoonotic paramyxoviruses in the genus Henipavirus, have recently emerged and continue to cause sporadic disease outbreaks in humans and animals. Mortality rates of up to 75% have been reported in humans, but there are presently no clinically licensed therapeutics for treating henipavirus-induced disease. A recent report indicated that chloroquine, used in malaria therapy for over 70 years, prevented infection with Nipah virus in vitro. Chloroquine was assessed using a ferret model of lethal Nipah virus infection and found to be ineffective against Nipah virus infection in vivo.
authors.affiliation: CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria 3220, Australia. jackie.pallister@csiro.au
authors.forename: Jackie
authors.initials: J
authors.lastname: Pallister
authors.forename: Deborah
authors.initials: D
authors.lastname: Middleton
authors.forename: Gary
authors.initials: G
authors.lastname: Crameri
authors.forename: Manabu
authors.initials: M
authors.lastname: Yamada
authors.forename: Reuben
authors.initials: R
authors.lastname: Klein
authors.forename: Tim J
authors.initials: TJ
authors.lastname: Hancock
authors.forename: Adam
authors.initials: A
authors.lastname: Foord
authors.forename: Brian
authors.initials: B
authors.lastname: Shiell
authors.forename: Wojtek
authors.initials: W
authors.lastname: Michalski
authors.forename: Christopher C
authors.initials: CC
authors.lastname: Broder
authors.forename: Lin-Fa
authors.initials: LF
authors.lastname: Wang
mesh_terms: D000820:Animal Diseases / Q000188:drug therapy / Q000821:virology; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002738:Chloroquine / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D005289:Ferrets / Q000378:metabolism / Q000821:virology*; D045464:Henipavirus Infections / Q000188:drug therapy*; D006801:Humans; D045405:Nipah Virus / Q000187:drug effects*; D012367:RNA, Viral / Q000378:metabolism
chemical_list: D000998:Antiviral Agents; D012367:RNA, Viral; D002738:Chloroquine