Regulation of duplex DNA strand displacement by visible light sensitive bis-peptide nucleic acid.
A novel visible light sensitive azobenzene (AZO) was synthesized and introduced into bis-peptide nucleic acid (bis-PNA), which consists of two homopyrimidine PNA strands, as a linker. Visible light irradiation of the bis-PNA-AZO conjugate induced photoisomerization of the azobenzene moiety from trans to cis. The cis-form of bis-PNA-AZO displaced the complementary duplex DNA more efficiently than the trans-form.
Sawada
Shinjiro
S
Graduate School of Science, and Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka 567-0047, Japan.
Imada
Ichiro
I
Kato
Nobuo
N
Kaihatsu
Kunihiro
K
D001391:Azo Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000528:radiation effects; D004247:DNA / Q000737:chemistry*; D031541:Fluorescence Resonance Energy Transfer; D008027:Light; D020135:Peptide Nucleic Acids / Q000737:chemistry* / Q000528:radiation effects
D001391:Azo Compounds; D020135:Peptide Nucleic Acids; D004247:DNA; C009850:azobenzene