Multiple loci on 8q24 associated with prostate cancer susceptibility.
Previous studies have identified multiple loci on 8q24 associated with prostate cancer risk. We performed a comprehensive analysis of SNP associations across 8q24 by genotyping tag SNPs in 5,504 prostate cancer cases and 5,834 controls. We confirmed associations at three previously reported loci and identified additional loci in two other linkage disequilibrium blocks (rs1006908: per-allele OR = 0.87, P = 7.9 x 10(-8); rs620861: OR = 0.90, P = 4.8 x 10(-8)). Eight SNPs in five linkage disequilibrium blocks were independently associated with prostate cancer susceptibility.
Al Olama
Ali Amin
AA
Cancer Research UK Genetic Epidemiology Unit, University of Cambridge, Cambridge, UK.
Kote-Jarai
Zsofia
Z
Giles
Graham G
GG
Guy
Michelle
M
Morrison
Jonathan
J
Severi
Gianluca
G
Leongamornlert
Daniel A
DA
Tymrakiewicz
Malgorzata
M
Jhavar
Sameer
S
Saunders
Ed
E
Hopper
John L
JL
Southey
Melissa C
MC
Muir
Kenneth R
KR
English
Dallas R
DR
Dearnaley
David P
DP
Ardern-Jones
Audrey T
AT
Hall
Amanda L
AL
O'Brien
Lynne T
LT
Wilkinson
Rosemary A
RA
Sawyer
Emma
E
Lophatananon
Artitaya
A
Horwich
Alan
A
Huddart
Robert A
RA
Khoo
Vincent S
VS
Parker
Christopher C
CC
Woodhouse
Christopher J
CJ
Thompson
Alan
A
Christmas
Tim
T
Ogden
Chris
C
Cooper
Colin
C
Donovan
Jenny L
JL
Hamdy
Freddie C
FC
Neal
David E
DE
Eeles
Rosalind A
RA
Easton
Douglas F
DF
D002898:Chromosomes, Human, Pair 8; D004198:Disease Susceptibility; D015894:Genome, Human; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms / Q000235:genetics*; D012307:Risk Factors