Identification of a new prostate cancer susceptibility locus on chromosome 8q24.
We report a genome-wide association study in 10,286 cases and 9,135 controls of European ancestry in the Cancer Genetic Markers of Susceptibility (CGEMS) initiative. We identify a new association with prostate cancer risk on chromosome 8q24 (rs620861, P = 1.3 x 10(-10), heterozygote OR = 1.17, 95% CI 1.10-1.24; homozygote OR = 1.33, 95% CI 1.21-1.45). This defines a new locus associated with prostate cancer susceptibility on 8q24.
Yeager
Meredith
M
Core Genotyping Facility, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland, USA. yeagerm@mail.nih.gov
Chatterjee
Nilanjan
N
Ciampa
Julia
J
Jacobs
Kevin B
KB
Gonzalez-Bosquet
Jesus
J
Hayes
Richard B
RB
Kraft
Peter
P
Wacholder
Sholom
S
Orr
Nick
N
Berndt
Sonja
S
Yu
Kai
K
Hutchinson
Amy
A
Wang
Zhaoming
Z
Amundadottir
Laufey
L
Feigelson
Heather Spencer
HS
Thun
Michael J
MJ
Diver
W Ryan
WR
Albanes
Demetrius
D
Virtamo
Jarmo
J
Weinstein
Stephanie
S
Schumacher
Fredrick R
FR
Cancel-Tassin
Geraldine
G
Cussenot
Olivier
O
Valeri
Antoine
A
Andriole
Gerald L
GL
Crawford
E David
ED
Haiman
Christopher A
CA
Henderson
Brian
B
Kolonel
Laurence
L
Le Marchand
Loic
L
Siddiq
Afshan
A
Riboli
Elio
E
Key
Timothy J
TJ
Kaaks
Rudolf
R
Isaacs
William
W
Isaacs
Sarah
S
Wiley
Kathleen E
KE
Gronberg
Henrik
H
Wiklund
Fredrik
F
Stattin
Pär
P
Xu
Jianfeng
J
Zheng
S Lilly
SL
Sun
Jielin
J
Vatten
Lars J
LJ
Hveem
Kristian
K
Kumle
Merethe
M
Tucker
Margaret
M
Gerhard
Daniela S
DS
Hoover
Robert N
RN
Fraumeni
Joseph F
JF
Hunter
David J
DJ
Thomas
Gilles
G
Chanock
Stephen J
SJ
D002898:Chromosomes, Human, Pair 8; D004198:Disease Susceptibility; D005819:Genetic Markers; D015894:Genome, Human; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms / Q000235:genetics*; D012307:Risk Factors; D044465:White People / Q000235:genetics
D005819:Genetic Markers