Capillary electrophoretic enantioseparation of m-nisoldipine using two different beta-cyclodextrins.
The methods for the enantioseparation of m-nisoldipine, a new 1,4-dihydropyridine calcium ion antagonist, were developed. The elaborated methods of m-nisoldipine enantiomers separation were successfully performed using an anionic CD-sulfobutyl ether-beta-CD (SBE-beta-CD) or carboxymethyl-beta-CD as chiral selector. However, the results indicated that SBE-beta-CD was a better chiral selector for enantioseparation of the neutral m-nisoldipine. Furthermore, comparing the two SBE-beta-CDs, the derivative with a higher degree of substitution (DS) of 7.0 induced better enantioresolution than the one with low DS (4.0). In addition, possible chiral recognition mechanisms of dihydropyridines were discussed.
Kong
Dezhi
D
Department of Pharmaceutical Analysis, School of Pharmacy, Hebei Medical University, Shijiazhuang, PR China.
Yang
Wei
W
Duan
Kunfeng
K
Cui
Yang
Y
Xing
Songsong
S
Zhang
Xiaowei
X
Sheng
Xiaona
X
Zhang
Lantong
L
D002121:Calcium Channel Blockers / Q000737:chemistry* / Q000302:isolation & purification*; D019075:Electrophoresis, Capillary; D006863:Hydrogen-Ion Concentration; D015737:Nisoldipine / Q000737:chemistry* / Q000302:isolation & purification*; D013237:Stereoisomerism; D013696:Temperature; D047392:beta-Cyclodextrins / Q000737:chemistry*
D002121:Calcium Channel Blockers; D047392:beta-Cyclodextrins; D015737:Nisoldipine; C031215:betadex