title: Molecular networks as sensors and drivers of common human diseases.
abstract: The molecular biology revolution led to an intense focus on the study of interactions between DNA, RNA and protein biosynthesis in order to develop a more comprehensive understanding of the cell. One consequence of this focus was a reduced attention to whole-system physiology, making it difficult to link molecular biology to clinical medicine. Equipped with the tools emerging from the genomics revolution, we are now in a position to link molecular states to physiological ones through the reverse engineering of molecular networks that sense DNA and environmental perturbations and, as a result, drive variations in physiological states associated with disease.
authors.affiliation: Pacific Biosciences, 1505 Adams Drive, Menlo Park, California 94025, USA. eschadt@pacificbiosciences.com
authors.forename: Eric E
authors.initials: EE
authors.lastname: Schadt
mesh_terms: D000818:Animals; D004194:Disease / Q000235:genetics; D053263:Gene Regulatory Networks; D055106:Genome-Wide Association Study; D023281:Genomics; D006801:Humans; D053858:Metabolic Networks and Pathways; D008967:Molecular Biology