title: Platelet hyperactivity during exercise leading to iterative coronary stent thrombosis: clinical implications.
abstract: Exercise may induce platelet activation in spite of using antiplatelet treatment. We present a case where the initial acute coronary syndrome and the iterative stent thrombosis always occurred after intense and prolonged physical effort. For this patient the at rest response to platelet inhibition with antiplatelet treatments was assessed as adequate, but after exercise the patient developed platelet activation which could be the trigger of his stent thrombosis.
authors.affiliation: Department of Cardiology, Grenoble University Hospital, Grenoble, France. OOrmezzano@chu-grenoble.fr
authors.forename: Olivier
authors.initials: O
authors.lastname: Ormezzano
authors.forename: Benoit
authors.initials: B
authors.lastname: Polack
authors.forename: Gérald
authors.initials: G
authors.lastname: Vanzetto
authors.forename: Mohamed
authors.initials: M
authors.lastname: Sahnoun
authors.forename: Jacques
authors.initials: J
authors.lastname: Machecourt
mesh_terms: D023903:Coronary Restenosis / Q000209:etiology*; D003328:Coronary Thrombosis / Q000150:complications / Q000628:therapy*; D015444:Exercise / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015539:Platelet Activation / Q000502:physiology*; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D012008:Recurrence; D015607:Stents
chemical_list: D010975:Platelet Aggregation Inhibitors