Sleep deprivation and its effects on object-selective attention.
Sleep deprivation (SD) affects attention but it is an open question as to whether all subtypes of attention are similarly affected. We investigated the effects of 24 h of total SD on object-selective attention. 26 healthy, young adults viewed quartets of alternating faces or place scenes and performed selective judgments on faces only, scenes only or both faces and scenes. Volunteers underwent fMRI following a normal night of sleep and again following approximately 24 h of total sleep deprivation in a counterbalanced fashion. Sleep deprivation resulted in slower and less accurate picture classification as well as poorer recognition memory for scenes. Attention strongly modulated activation in the Parahippocampal Place Area (PPA). Task-related activation in the fronto-parietal cortex and PPA was reduced in SD, but the relative modulation of PPA activation by attention was preserved. Psychophysiological interaction between the left intra-parietal sulcus and the PPA that was clearly present after a normal night of sleep was reduced below threshold following SD suggesting that PPI may be a more sensitive method of detecting change in selective attention. Sleep deprivation may affect object-selective attention in addition to exerting a task-independent deficit in attention.
Chee
Michael W L
MW
Cognitive Neuroscience Laboratory, Duke-NUS Graduate Medical School, Singapore. michael.chee@duke-nus.edu.sg
Tan
Jiat Chow
JC
Parimal
Sarayu
S
Zagorodnov
Vitali
V
D001288:Attention / Q000502:physiology*; D001931:Brain Mapping; D003072:Cognition Disorders / Q000209:etiology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009434:Neural Pathways / Q000503:physiopathology; D009473:Neuronal Plasticity; D009483:Neuropsychological Tests; D020534:Parahippocampal Gyrus / Q000503:physiopathology; D010775:Photic Stimulation; D011930:Reaction Time; D021641:Recognition, Psychology / Q000502:physiology; D012890:Sleep / Q000502:physiology; D012892:Sleep Deprivation / Q000150:complications / Q000503:physiopathology*; D013788:Thalamus / Q000503:physiopathology; D055815:Young Adult