title: Attention and visual orienting in siblings, schizophrenic patients, and controls: impairment in attentional disengagement.
abstract: Visual orienting tasks reveal an impaired disengagement of attention in schizophrenia. We explored visual orientation in 20 schizophrenia patients (SZ), 20 full siblings (FS), and 20 controls (C) using a cued target detection (gap vs. no gap) and a choice reaction time task. SZ but not FS had longer reaction time with comparable reactions to warning. In contrast to C, SZ and FS did not display a significant gap effect. The disengagement deficit in schizophrenia patients and their siblings provides arguments for altered early attention mechanisms (in schizophrenic patients and their nonpsychotic relatives).
authors.affiliation: INSERM U894; Laboratory of Pathophysiology of Psychiatric Diseases, University Paris Descartes, Saint Anne Hospital, Paris 75014, France.
authors.forename: Marion
authors.initials: M
authors.lastname: Chirio
authors.forename: Marie-Odile
authors.initials: MO
authors.lastname: Krebs
authors.forename: Rogeria
authors.initials: R
authors.lastname: Waismann
authors.forename: Jean Marie
authors.initials: JM
authors.lastname: Vanelle
authors.forename: Jean Pierre
authors.initials: JP
authors.lastname: Olié
authors.forename: Isabelle
authors.initials: I
authors.lastname: Amado
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D019958:Attention Deficit and Disruptive Behavior Disorders / Q000209:etiology*; D003463:Cues; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D009949:Orientation / Q000502:physiology*; D010775:Photic Stimulation / Q000379:methods; D011569:Psychiatric Status Rating Scales; D011930:Reaction Time / Q000502:physiology; D012559:Schizophrenia / Q000150:complications*; D012565:Schizophrenic Psychology; D035781:Siblings; D017603:Signal Detection, Psychological / Q000502:physiology; D013028:Space Perception / Q000502:physiology*; D055815:Young Adult