Renal dysfunction due to leukemic infiltration of kidneys in a case of chronic lymphocytic leukemia.
Renal failure due to leukemic infiltration of kidney in chronic lymphocytic leukemia is an extremely rare condition. The authors report a case of a 59-year-old white female, with a past medical history of chronic lymphocytic leukemia (CLL) with 2 years of evolution without medical therapy, admitted with nonoliguric acute renal failure needing dialysis. Renal biopsy showed extensive small lymphocytes' infiltration in the cortical interstitium by CLL cells. Cyclophosphamide and prednisolone were started and 1 month later changed to fludarabine plus cyclophosphamide with improvement of renal function. Although renal failure due to leukemic infiltration has been described in many cases of acute leukemia, only 11 cases of renal failure due to CLL cells' infiltration have been described in the literature. Renal histology is an extremely important tool to confirm diagnosis.
Ferreira
Ana Carina
AC
Department of Nephrology, Hospital of Curry Cabral, Lisbon, Portugal.
Brum
Sandra
S
Carvalho
Dulce
D
Pataca
Isabel
I
Carvalho
Fernanda
F
Santos
Maria Céu
MC
Santos
João Ribeiro
JR
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007668:Kidney / Q000000981:diagnostic imaging / Q000473:pathology*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000188:drug therapy / Q000473:pathology*; D017254:Leukemic Infiltration / Q000188:drug therapy / Q000473:pathology*; D008875:Middle Aged; D011239:Prednisolone / Q000008:administration & dosage; D006435:Renal Dialysis / Q000379:methods; D051437:Renal Insufficiency / Q000473:pathology; D014463:Ultrasonography; D014740:Vidarabine / Q000008:administration & dosage / Q000031:analogs & derivatives
D003520:Cyclophosphamide; D011239:Prednisolone; D014740:Vidarabine; C024352:fludarabine