title: Synthesis and properties of a novel 2',4'-BNA bearing a urea bridged structure.
abstract: Three kinds of novel bridged nucleic acid (BNA) monomers bearing carbamate or urea bridged structures, were designed and synthesized. One of these monomers, a urea-type BNA monomer was successfully incorporated into oligodeoxynucleotides (ODNs), and properties of the ODNs were evaluated. The ODNs containing the urea-type BNA monomers showed RNA selective hybridizing profiles and significant enzymatic stability.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565-0871, Japan.
authors.forename: Aiko
authors.initials: A
authors.lastname: Yahara
authors.forename: Masaru
authors.initials: M
authors.lastname: Nishida
authors.forename: Takeshi
authors.initials: T
authors.lastname: Baba
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Kodama
authors.forename: Takeshi
authors.initials: T
authors.lastname: Imanishi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Obika
mesh_terms: D001952:Bridged-Ring Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D002219:Carbamates / Q000737:chemistry; D004247:DNA / Q000737:chemistry; D009691:Nucleic Acid Denaturation; D009696:Nucleic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D009838:Oligodeoxyribonucleotides / Q000737:chemistry*; D012313:RNA / Q000737:chemistry; D014508:Urea / Q000737:chemistry*
chemical_list: D001952:Bridged-Ring Compounds; D002219:Carbamates; D009696:Nucleic Acids; D009838:Oligodeoxyribonucleotides; D012313:RNA; D014508:Urea; D004247:DNA