title: Crack cocaine use increases the incidence of AIDS-defining events in French Guiana.
abstract: We conducted a retrospective cohort study to determine the influence of crack cocaine use on the outcomes of HIV infection. The use of crack cocaine was associated with an increased incidence of AIDS: 27.8 per 100 person-years versus 6.6 per 100 person-years for nonusers, adjusted hazard ratio = 3.8 (1.9-7.5), P < 0.001. More specifically, crack users had a greater incidence of disseminated histoplasmosis, pneumocystosis, pulmonary tuberculosis, bacterial pneumonia, oesophageal candidiasis, cerebral toxoplasmosis, salmonellosis, and genital herpes. The care of HIV-infected crack users is particularly challenging and requires additional efforts to reduce the high morbidity of these patients.
authors.affiliation: Centre d'Investigation Clinique Epidémiologie Clinique Antilles Guyane (CIC EC CIE802), French Guiana.
authors.forename: Mathieu
authors.initials: M
authors.lastname: Nacher
authors.forename: Antoine
authors.initials: A
authors.lastname: Adenis
authors.forename: Matthieu
authors.initials: M
authors.lastname: Hanf
authors.forename: Leila
authors.initials: L
authors.lastname: Adriouch
authors.forename: Vincent
authors.initials: V
authors.lastname: Vantilcke
authors.forename: Myriam
authors.initials: M
authors.lastname: El Guedj
authors.forename: Tania
authors.initials: T
authors.lastname: Vaz
authors.forename: Julie
authors.initials: J
authors.lastname: Dufour
authors.forename: Pierre
authors.initials: P
authors.lastname: Couppié
mesh_terms: D023241:Antiretroviral Therapy, Highly Active; D019970:Cocaine-Related Disorders / Q000150:complications / Q000401:mortality*; D016578:Crack Cocaine / Q000009:adverse effects*; D018450:Disease Progression; D005260:Female; D005616:French Guiana / Q000453:epidemiology; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy / Q000401:mortality*; D006801:Humans; D015994:Incidence; D008297:Male; D012189:Retrospective Studies; D019562:Viral Load
chemical_list: D016578:Crack Cocaine