title: [Does dilution have an impact on cosmetic results with BoNT/A? Complex-protein-free BoNT/A for treatment of glabella lines].
abstract: BACKGROUND
  In this 2-armed, randomized study we investigated the efficacy and tolerability of complex-protein-free botulinum neurotoxin type A (BoNT/A), applied in two different dilution volumes for treatment of glabellar lines.
  
  
  METHODS
  40 patients with grade 2-3 glabellar lines (Facial Wrinkle Scale) received treatment with 25U BoNT/A (Xeomin). 100U of botulinum neurotoxin were diluted in 2.5 ml (group I) or 4 ml sodium chloride solution (group II). Responders showed an improvement in the wrinkle score (independent rater) of at least one point. RESULTS. Response rates two weeks after treatment were 100% / 89.5%, at 3 months 84.2% / 64.7% and at 4 months 53.3% / 61.5% (groups I / II respectively). There was no significant difference between the two dilutions.
  
  
  CONCLUSIONS
  Complex-protein-free botulinum neurotoxin type A in both dilutions effectively reduced severity of glabellar lines. There was no statistically significant difference in efficacy between the two dilutions.
authors.affiliation: Dermatologikum Hamburg. prager@dermatologikum.de
authors.forename: W
authors.initials: W
authors.lastname: Prager
authors.forename: I
authors.initials: I
authors.lastname: Zschocke
authors.forename: C
authors.initials: C
authors.lastname: Reich
authors.forename: L
authors.initials: L
authors.lastname: Brocatti
authors.forename: K
authors.initials: K
authors.lastname: Henning
authors.forename: V
authors.initials: V
authors.lastname: Steinkraus
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage* / Q000737:chemistry*; D016895:Culture Media, Serum-Free / Q000737:chemistry; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015595:Skin Aging / Q000187:drug effects* / Q000473:pathology*; D012995:Solubility; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D016895:Culture Media, Serum-Free; D019274:Botulinum Toxins, Type A