Barriers to enantiocontrol in Lewis acid catalyzed hetero-Diels-Alder reactions.
Lewis bases, including reactant aldehydes, inhibit the rate of conversion for cycloaddition and those, like aldehydes or nitriles, cause a decrease in enantiocontrol due to the Lewis acidity of the activated complex.
Wang
Xiaochen
X
Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA.
Li
Zhuoyan
Z
Doyle
Michael P
MP
D000143:Acids / Q000737:chemistry; D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D009570:Nitriles / Q000737:chemistry; D013237:Stereoisomerism
D000143:Acids; D000447:Aldehydes; D009570:Nitriles