Intercepting the synthesis of triazine dendrimers with nucleophilic pharmacophores: a general strategy toward drug delivery vehicles.
The camptothecin ester of isonipecotic acid is installed on a triazine dendrimer intermediate obtained through an iterative, scalable route to ultimately yield cationic and PEGylated targets with activities in cell culture comparable to free drug.
Venditto
Vincent J
VJ
Department of Chemistry, Texas A&M University, College Station, TX 77843, USA.
Allred
Kimberly
K
Allred
Clinton D
CD
Simanek
Eric E
EE
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D002166:Camptothecin / Q000138:chemical synthesis / Q000737:chemistry / Q000633:toxicity; D045744:Cell Line, Tumor; D050091:Dendrimers / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000737:chemistry; D006801:Humans; D007540:Isonipecotic Acids / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry; D014227:Triazines / Q000737:chemistry*
D000970:Antineoplastic Agents; D050091:Dendrimers; D004337:Drug Carriers; D007540:Isonipecotic Acids; D014227:Triazines; D011092:Polyethylene Glycols; D002166:Camptothecin