title: [Expression of lymphatic vessel endothelial hyaluronan receptor-1 in human colorectal cancer and its clinical significance].
abstract: OBJECTIVE
  To examine the expression of lymph vessel endothelial hyaluronan receptor-1 (LYVE-1) in human colorectal carcinoma and to evaluate the relationship of LYVE-1 with lymph mode metastasis and prognosis.
  
  
  METHODS
  Colonic cancer samples of 40 cases were collected. The expression of LYVE-1 was determined by RT-PCR and quantified by real-time quantitative PCR. LVD and MVD were detected by immunohistochemistry staining. The relationship of LYVE-1 and LVD with lymph mode metastasis and prognosis were analyzed. All the patients were followed up for at least 3 years.
  
  
  RESULTS
  The expression of LYVE-1 and the count of LVD were significantly higher in tumor tissue than those in common colon tissue (P<0.05). In the majority of tumors, the higher count of LVD indicated lymphangiogenesis. The recurrence rates in low LVD group and high LVD group were 46.7% and 60.0% respectively (P<0.05). The survival rates in the above two groups were 90.1% and 56.7% respectively (P<0.05). No significant correlation was found between LYVE-1 and recurrence rate (P>0.05) or overall survival (P>0.05).
  
  
  CONCLUSIONS
  LYVE-1 indicates an increase of lymphangiogenesis in colorectal carcinoma and LVD can be used to evaluate the prognosis for colorectal cancer patients.
authors.affiliation: Department of General Surgery, Tongji Hospital, Tongji University, Shanghai, China.
authors.forename: Zhan-xia
authors.initials: ZX
authors.lastname: Li
authors.forename: Guo-feng
authors.initials: GF
authors.lastname: Zhang
authors.forename: Zhi-qian
authors.initials: ZQ
authors.lastname: Hu
authors.forename: Yue-zu
authors.initials: YZ
authors.lastname: Fan
mesh_terms: D000328:Adult; D000368:Aged; D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D012333:RNA, Messenger / Q000235:genetics; D033921:Vesicular Transport Proteins / Q000378:metabolism*
chemical_list: C119248:LYVE1 protein, human; D012333:RNA, Messenger; D033921:Vesicular Transport Proteins