Bile acids in regulation of intestinal physiology.
In addition to their roles in facilitating lipid digestion and absorption, bile acids are recognized as important regulators of intestinal function. Exposure to bile acids can dramatically influence intestinal transport and barrier properties; in recent years, they have also become appreciated as important factors in regulating cell growth and survival. Indeed, few cells reside within the intestinal mucosa that are not altered to some degree by exposure to bile acids. The past decade saw great advances in the knowledge of how bile acids exert their actions at the cellular and molecular levels. In this review, we summarize the current understanding of the role of bile acids in regulation of intestinal physiology.
Keating
Niamh
N
Department of Molecular Medicine, Royal College of Surgeons in Ireland Education and Research Centre, Smurfit Building, Beaumont Hospital, Dublin 9, Ireland.
Keely
Stephen J
SJ
D000818:Animals; D001646:Bile / Q000378:metabolism*; D001647:Bile Acids and Salts / Q000096:biosynthesis / Q000378:metabolism*; D004041:Dietary Fats / Q000378:metabolism; D004063:Digestion / Q000502:physiology; D020895:Enterocytes / Q000378:metabolism; D005769:Gastrointestinal Motility / Q000502:physiology; D006801:Humans; D007408:Intestinal Absorption / Q000502:physiology*; D007413:Intestinal Mucosa / Q000378:metabolism*; D007421:Intestine, Small / Q000378:metabolism*; D007422:Intestines / Q000502:physiology; D008099:Liver / Q000201:enzymology / Q000378:metabolism; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled / Q000819:agonists / Q000378:metabolism; D015398:Signal Transduction
D001647:Bile Acids and Salts; D004041:Dietary Fats; D018160:Receptors, Cytoplasmic and Nuclear; D043562:Receptors, G-Protein-Coupled