Multifunctional nanoparticles for combined doxorubicin and photothermal treatments.
To facilitate combined doxorubicin and photothermal treatments, we developed doxorubicin-loaded poly(lactic-co-glycolic acid)-gold half-shell nanoparticles (DOX-loaded PLGA-Au H-S NPs) by depositing Au films on DOX-loaded PLGA NPs. As the PLGA NPs biodegraded, DOX was released, and heat was locally generated upon near-infrared (NIR) irradiation due to NIR resonance of DOX-loaded PLGA H-S NPs. Compared with chemotherapy or photothermal treatment alone, the combined treatment demonstrated a synergistic effect, resulting in higher therapeutic efficacy and shorter treatment times. Since our NPs selectively deliver both heat and drug to tumorigenic regions, they may improve the therapeutic effectiveness with minimal side effects.
Park
Huiyul
H
National Core Research Center for Nanomedical Technology, Yonsei University, Seoul 120-749, Korea.
Yang
Jaemoon
J
Lee
Jaemin
J
Haam
Seungjoo
S
Choi
In-Hong
IH
Yoo
Kyung-Hwa
KH
D000970:Antineoplastic Agents / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D001672:Biocompatible Materials / Q000737:chemistry; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D004317:Doxorubicin / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D004337:Drug Carriers / Q000737:chemistry*; D006046:Gold / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D006979:Hyperthermia, Induced; D007259:Infrared Rays / Q000627:therapeutic use; D019344:Lactic Acid / Q000737:chemistry; D053768:Metal Nanoparticles / Q000737:chemistry*; D008856:Microscopy, Fluorescence; D050997:Nanomedicine / Q000379:methods*; D010789:Phototherapy; D011100:Polyglycolic Acid / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer
D000970:Antineoplastic Agents; D001672:Biocompatible Materials; D004337:Drug Carriers; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D006046:Gold; D004317:Doxorubicin