Antioxidant and hepatoprotective activities of Ocimum basilicum Linn. and Trigonella foenum-graecum Linn. against H2O2 and CCL4 induced hepatotoxicity in goat liver.
Significant hepatoprotective effects were obtained by ethanolic extract of leaves of O. basilicum and T. foenum-graecum against liver damage induced by H2O2 and CCl4 as evidenced by decreased levels of antioxidant enzymes (enzymatic and non enzymatic). The extract also showed significant anti lipid peroxidation effects in vitro, besides exhibiting significant activity in superoxide radical and nitric oxide radical scavenging, indicating their potent antioxidant effects.
Meera
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R
Department of Pharmaceutical Chemistry, K.M. College of Pharmacy, Uthangudi, Madurai-625 107, India. meeraharsa@yahoo.com
Devi
P
P
Kameswari
B
B
Madhumitha
B
B
Merlin
N J
NJ
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002251:Carbon Tetrachloride / Q000037:antagonists & inhibitors / Q000633:toxicity; D006041:Goats; D006861:Hydrogen Peroxide / Q000037:antagonists & inhibitors / Q000633:toxicity; D066298:In Vitro Techniques; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D018649:Ocimum basilicum; D018384:Oxidative Stress / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal; D029910:Trigonella
D000975:Antioxidants; D010936:Plant Extracts; D006861:Hydrogen Peroxide; D002251:Carbon Tetrachloride