title: Biotransformation of bromosesquiterpenes by marine fungi.
abstract: Biotransformation of bromosesquiterpenes was investigated with two types of fungi, Rhinocladiella atrovirens NRBC 32362 and also Rhinocladiella sp. K-001, isolated from the Okinawan brown alga Stypopodium zonale. R. atrovirens NRBC 32362 converted aplysistatin 1 into three compounds 5alpha-hydroxyaplysistatin 4, 5alpha-hydroxyisoaplysistatin 5 and 9beta-hydroxyaplysistatin 6. Transformation of 1, palisadin A 2 and 12-hydroxypalisadin B 3 by Rhinocladiella sp. K-001 gave two compounds, 3,4-dihydroaplysistatin 7 and 9,10-dehydrobromopalisadin A 8.
authors.affiliation: Department of Chemistry, Biology and Marine Science, University of the Ryukyus, Nishihara, Okinawa 903-0213, Japan. k078551@eve.u-ryukyu.ac.jp
authors.forename: Masahiro
authors.initials: M
authors.lastname: Koshimura
authors.forename: Takamitsu
authors.initials: T
authors.lastname: Utsukihara
authors.forename: Mai
authors.initials: M
authors.lastname: Kawamoto
authors.forename: Michihiko
authors.initials: M
authors.lastname: Saito
authors.forename: C Akira
authors.initials: CA
authors.lastname: Horiuchi
authors.forename: Masayuki
authors.initials: M
authors.lastname: Kuniyoshi
mesh_terms: D001711:Biotransformation; D017605:Bromine Compounds / Q000378:metabolism*; D005658:Fungi / Q000302:isolation & purification / Q000378:metabolism*; D044722:Laurencia / Q000737:chemistry*; D000459:Phaeophyceae / Q000382:microbiology; D010936:Plant Extracts / Q000378:metabolism*; D012717:Sesquiterpenes / Q000378:metabolism*
chemical_list: D017605:Bromine Compounds; D010936:Plant Extracts; D012717:Sesquiterpenes; C013402:aplysistatin