Prolonged dependence of ischemic penumbra on induced hypertension.
BACKGROUND
Pharmacological elevation of blood pressure in acute stroke due to large artery occlusion may enhance collateral blood flow and salvage penumbral tissue. The duration of viability of human penumbral tissue under such circumstances is unclear.


OBJECTIVE
To describe a patient presenting with acute middle cerebral artery occlusion treated with induced hypertension who had prolonged survival of penumbral tissue with subsequent infarct extension after pressor agents were withdrawn.


CONCLUSIONS
Enhanced collateral flow by elevation of blood pressure may result in prolonged survival of the ischemic penumbra which remains dependent on persistent use of pressor agents.
Verro
Piero
P
Department of Neurology and Stroke Program, University of California, Davis Medical Center, Sacramento, CA 95817, USA. piero.verro@ucdmc.ucdavis.edu
Chow
Matthew
M
D000208:Acute Disease; D001921:Brain / Q000098:blood supply / Q000473:pathology / Q000503:physiopathology; D002533:Cerebral Angiography; D006801:Humans; D006973:Hypertension / Q000503:physiopathology; D020244:Infarction, Middle Cerebral Artery / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D018810:Magnetic Resonance Angiography; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed