Endometriosis: the elusive epiphenomenon.
The denervation-reinnervation view proposes that retrograde menstruation results from loss of normal, fundocervical polarity caused by injuries to uterine nerves. Injuries may be sporadic (following vaginal delivery) or recurrent (after persistent straining during defaecation) creating very different appearances at laparoscopy. Clinical symptoms of pelvic pain, menstrual problems, dyspareunia, and dysmenorrhoea result from aberrant reinnervation that may occur with, or without deposits of pelvic endometriosis. Endometrium, delivered by retrograde menstruation, adheres to any injured tissues in the lower pelvis. Classical 'endometriosis' is largely an epiphenomenon to underlying processes of denervation and reinnervation.
Quinn
M
M
mjquinn001@btinternet.com
D004715:Endometriosis / Q000209:etiology*; D005260:Female; D006801:Humans; D017699:Pelvic Pain / Q000209:etiology*; D020196:Trauma, Nervous System / Q000150:complications*; D014599:Uterus / Q000294:innervation