Mechanisms underlying behavioural comorbidities associated with kindling.
There is a substantial incidence of interictal behavioural comorbidities with epilepsy. These comorbidities can often be more difficult to treat than the seizures themselves and are a significant burden to the afflicted individuals and health care system. This article provides a brief overview of the behavioural comorbidities associated with epilepsy in humans and how the kindling of animals models these behavioural anomalies. Specific attention is paid to kindling in frontal cortex, its effects on skilled reaching behaviour and underlying mechanisms.
Teskey
G Campbell
GC
Behavioural Neuroscience Research Group, Department of Psychology, University of Calgary, Calgary, Alberta, Canada.
D000818:Animals; D004827:Epilepsy / Q000503:physiopathology*; D006801:Humans; D007696:Kindling, Neurologic / Q000502:physiology*; D020187:REM Sleep Behavior Disorder / Q000503:physiopathology*