title: Interleukin-23 receptor gene variants in Hungarian systemic lupus erythematosus patients.
abstract: OBJECTIVE
  We investigated the association between systemic lupus erythematosus (SLE) and polymorphisms of interleukin-23 receptor (IL23R) gene, which was recently found to be associated with autoimmune diseases, including Crohn's disease, rheumatoid arthritis, psoriasis and ankylosing spondylitis.
  
  
  METHODS
  We analysed 383 SLE patients and 253 controls for rs11805303, rs10889677, rs1004819, rs2201841, rs11209032, 11209026, rs10489629, rs7517847 and rs7530511 variants.
  
  
  METHODS
  The analysis was carried out using PCR-RFLP methods. Logistic regression analysis was used to compare the genotype distributions of the polymorphisms and haplotypes between the SLE patients and healthy controls.
  
  
  RESULTS
  We observed no significant difference of the examined variants between the patient and control groups.
  
  
  CONCLUSIONS
  Our results suggest that neither single nucleotide variants nor haplotypes of IL23R indicate susceptibility to developing SLE in the Hungarian population.
authors.affiliation: Department of Medical Genetics, University of Pecs, Szigeti 12, 7624 Pecs, Hungary.
authors.forename: Eniko
authors.initials: E
authors.lastname: Safrany
authors.forename: Renata
authors.initials: R
authors.lastname: Hobor
authors.forename: Laszlo
authors.initials: L
authors.lastname: Jakab
authors.forename: Tunde
authors.initials: T
authors.lastname: Tarr
authors.forename: Veronika
authors.initials: V
authors.lastname: Csongei
authors.forename: Luca
authors.initials: L
authors.lastname: Jaromi
authors.forename: Csilla
authors.initials: C
authors.lastname: Sipeky
authors.forename: Andrea
authors.initials: A
authors.lastname: Valasek
authors.forename: Margit
authors.initials: M
authors.lastname: Zeher
authors.forename: Gyorgy
authors.initials: G
authors.lastname: Fust
authors.forename: Laszlo
authors.initials: L
authors.lastname: Czirjak
authors.forename: Bela
authors.initials: B
authors.lastname: Melegh
mesh_terms: D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D006814:Hungary; D008180:Lupus Erythematosus, Systemic / Q000208:ethnology* / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D018123:Receptors, Interleukin / Q000235:genetics*
chemical_list: C515500:IL23R protein, human; D018123:Receptors, Interleukin