title: The Helicobacter pylori Mfd protein is important for antibiotic resistance and DNA repair.
abstract: A Helicobacter pylori mutant defective in a putative mfd gene was constructed and characterized. The mfd gene is required for DNA repair and is involved in DNA recombination processes. The mfd mutant strain displayed a greatly increased susceptibility to antibiotics, indicating that this gene plays a significant role in the antibiotic resistance of H. pylori strain J99.
authors.affiliation: Division of Gastroenterology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea.
authors.forename: Gin Hyug
authors.initials: GH
authors.lastname: Lee
authors.forename: Jin-Yong
authors.initials: JY
authors.lastname: Jeong
authors.forename: Jun-Won
authors.initials: JW
authors.lastname: Chung
authors.forename: Won-Hee
authors.initials: WH
authors.lastname: Nam
authors.forename: Sun-Mi
authors.initials: SM
authors.lastname: Lee
authors.forename: Jhang-Ho
authors.initials: JH
authors.lastname: Pak
authors.forename: Kee Don
authors.initials: KD
authors.lastname: Choi
authors.forename: Ho June
authors.initials: HJ
authors.lastname: Song
authors.forename: Hwoon-Yong
authors.initials: HY
authors.lastname: Jung
authors.forename: Jin-Ho
authors.initials: JH
authors.lastname: Kim
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000502:physiology*; D015169:Colony Count, Microbial; D004260:DNA Repair; D024881:Drug Resistance, Bacterial; D017353:Gene Deletion; D016480:Helicobacter pylori / Q000187:drug effects* / Q000502:physiology*; D008826:Microbial Sensitivity Tests; D016685:Mitomycin / Q000494:pharmacology; D011995:Recombination, Genetic; D014157:Transcription Factors / Q000172:deficiency / Q000502:physiology*
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D014157:Transcription Factors; C072103:transcription repair coupling factor protein, Bacteria; D016685:Mitomycin