[The inhibitory effects of Realgar bioleaching solution on S180 ascites-tumor and its toxicity].
OBJECTIVE
To investigate the inhibitory effect of Realgar bioleaching solution (RBS) on tumor S180 cells line and estimate its toxicity, to provide experimental evidence for the further exploit of Realgar.


METHODS
24 hours after the models of ascites-tumor bearing mice were established, the mice were injected RBS once a day. The survival rates of S180 ascites-tumor bearing mice injected in RBS was studied, and the RBS acute toxicity of mice produced by oral, intraperitoneal or intravenous was evaluated by Drug Median Lethal Dose (LD50).


RESULTS
The inhibitory effect of S180 cells in vivo had a dose-dependent manner. The survival rates of mice were 10% - 60% in the different dose in 15 days. The LD50 values of RBS by oral, intraperitoneal or intravenous were 5.27 mg/kg, 3.63 mg/kg and 2.68 mg/kg, respectively.


CONCLUSIONS
RBS has potent antitumor effect, LD50 value of RBS is lower than that of traditional medicine.
Xie
Qin-Jian
QJ
School of Pharmacy, School of Life Science, Lanzhou 730000, China. xieqinjian100@163.com
Zhang
Xu
X
Wang
Xin
X
Bai
Lu
L
Li
Hong-Yu
HY
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D001152:Arsenicals / Q000008:administration & dosage / Q000494:pharmacology*; D002286:Carcinoma, Ehrlich Tumor / Q000473:pathology*; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005260:Female; D005434:Flow Cytometry; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D011897:Random Allocation; D012510:Sarcoma 180 / Q000473:pathology*; D013440:Sulfides / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D015996:Survival Rate
D000970:Antineoplastic Agents; D001152:Arsenicals; D013440:Sulfides; C058317:arsenic disulfide