title: A comparative trial of three therapeutic regimens: ciprofloxacin-rifampin, ciprofloxacin-doxycycline and doxycycline-rifampin in the treatment of brucellosis.
abstract: This study was designed to compare the efficacy of ciprofloxacin plus rifampin (CR) and ciprofloxacin plus doxycycline (CD) versus doxycycline plus rifampin (DR) in the treatment of brucellosis. A total of 178 patients with brucellosis who were referred to the Sina Hospital, Hamedan, Iran, were included. The responses to therapy were observed in 166 cases (93.7%) - 59 were in the DR group, 59 in the CR group and 48 in the CD group. No significant differences in the therapeutic responses were observed (P = 0.09). Relapse was observed in 11.7% (DR 7.7%, CR 8.3% and CD 17.5%) after a six-month follow-up. No significant differences were also observed in relapse rates among the three groups (P = 0.35). We concluded that DR is still the first choice regimen and CR or CD may be used as alternatives for treatment of brucellosis in adults.
authors.affiliation: Department of Infectious Diseases, University of Medical Sciences, Hamedan, Iran.
authors.forename: Fariba
authors.initials: F
authors.lastname: Keramat
authors.forename: Mitra
authors.initials: M
authors.lastname: Ranjbar
authors.forename: Mojgan
authors.initials: M
authors.lastname: Mamani
authors.forename: Seyyed Hamid
authors.initials: SH
authors.lastname: Hashemi
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Zeraati
mesh_terms: D000328:Adult; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D002006:Brucellosis / Q000188:drug therapy*; D002939:Ciprofloxacin / Q000627:therapeutic use; D004318:Doxycycline / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D011446:Prospective Studies; D012008:Recurrence; D012293:Rifampin / Q000627:therapeutic use
chemical_list: D000890:Anti-Infective Agents; D002939:Ciprofloxacin; D004318:Doxycycline; D012293:Rifampin