title: Quantified characterization of human cutaneous normal scar using multiphoton microscopy.
abstract: The morphological alterations of human cutaneous normal scar were quantitatively analyzed using multiphoton microscopy (MPM) based on two-photon excited fluorescence and second harmonic generation. High-contrast, high-resolution images of normal scar and uninjured skin were obtained for comparison. In addition, some quantitative parameters have been extracted to quantitatively discriminate between normal scar and uninjured skin. The MPM combined with quantitative method enable a better understanding of microstructual alterations of the epidermis, elastic fiber, and collagen in normal scar. It may lead the way to making know the mechanism of normal scar formation and identifying feasible therapeutic options.
authors.affiliation: Institute of Laser and Optoelectronics Technology, Fujian Normal University, Fuzhou, P.R. China.
authors.forename: Xiaoqin
authors.initials: X
authors.lastname: Zhu
authors.forename: Shuangmu
authors.initials: S
authors.lastname: Zhuo
authors.forename: Liqin
authors.initials: L
authors.lastname: Zheng
authors.forename: Kecheng
authors.initials: K
authors.lastname: Lu
authors.forename: Xingshan
authors.initials: X
authors.lastname: Jiang
authors.forename: Jianxin
authors.initials: J
authors.lastname: Chen
authors.forename: Bifang
authors.initials: B
authors.lastname: Lin
mesh_terms: D000328:Adult; D002921:Cicatrix / Q000378:metabolism / Q000473:pathology*; D003094:Collagen / Q000378:metabolism; D020405:Dermis / Q000033:anatomy & histology / Q000378:metabolism / Q000473:pathology; D004547:Elastic Tissue / Q000033:anatomy & histology / Q000378:metabolism / Q000473:pathology; D004817:Epidermis / Q000033:anatomy & histology / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods; D036641:Microscopy, Fluorescence, Multiphoton / Q000379:methods*; D008875:Middle Aged; D009929:Organ Size; D012867:Skin / Q000033:anatomy & histology / Q000378:metabolism / Q000473:pathology*
chemical_list: D003094:Collagen