title: Effect of higher order aberrations on contrast sensitivity function in myopic eyes.
abstract: OBJECTIVE
  To evaluate the relation between higher order aberrations (HOAs) and contrast sensitivity function (CSF) in a population with myopia.
  
  
  METHODS
  In this case series, HOAs were measured in 70 myopic eyes over a 6-mm pupil. Contrast sensitivity was also measured. From the contrast sensitivity data, the area under the log contrast sensitivity function (AULCSF) was calculated. Pupil diameter was measured under photopic conditions.
  
  
  RESULTS
  Seventy right eyes of 70 myopic subjects with a mean age of 26.6 +/- 5.7 years were studied. The mean spherical equivalent and refractive astigmatism were -4.97 +/- 1.6 D and 0.93 +/- 0.5 D, respectively. AULCSF was significantly but negatively correlated with the cycloplegic spherical equivalent (r (2) = 0.57, P = 0.02), the root mean square (RMS) of total HOAs (r (2) = 0.065, P = 0.03), the RMS of fourth-order aberrations (r (2) = 0.089, P = 0.015), and the RMS of the spherical aberration (r (2) = 0.037, P = 0.004). AULCSF did not have any significant association with age, photopic pupil diameter, refractive astigmatism, or the RMS of the coma aberration.
  
  
  CONCLUSIONS
  Spherical and fourth-order aberrations significantly affect CSF in myopic eyes. However, the effect of myopia on CSF cannot be attributed only to HOAs. Other factors such as neural elements in the visual pathway should be taken into account.
authors.affiliation: Ophthalmic Research Center, Labbafinejad Medical Center, Shahid Beheshti Medical University, MC, Tehran, Iran. sepehrfeizi@yahoo.com
authors.forename: Sepehr
authors.initials: S
authors.lastname: Feizi
authors.forename: Farid
authors.initials: F
authors.lastname: Karimian
mesh_terms: D000293:Adolescent; D000328:Adult; D001251:Astigmatism / Q000503:physiopathology*; D015350:Contrast Sensitivity / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D009216:Myopia / Q000503:physiopathology*; D014792:Visual Acuity / Q000502:physiology; D055815:Young Adult