Post-translational modifications in circadian rhythms.
The pace has quickened in circadian biology research. In particular, an abundance of results focused on post-translational modifications (PTMs) is sharpening our view of circadian molecular clockworks. PTMs affect nearly all aspects of clock biology; in some cases they are essential for clock function and in others, they provide layers of regulatory fine-tuning. Our goal is to review recent advances in clock PTMs, help make sense of emerging themes, and spotlight intriguing (and perhaps controversial) new findings. We focus on PTMs affecting the core functions of eukaryotic clocks, in particular the functionally related oscillators in Neurospora crassa, Drosophila melanogaster, and mammalian cells.
Mehra
Arun
A
Department of Genetics, Dartmouth Medical School, Hanover, NH 03755, USA.
Baker
Christopher L
CL
Loros
Jennifer J
JJ
Dunlap
Jay C
JC
D000818:Animals; D001683:Biological Clocks / Q000502:physiology*; D056926:CLOCK Proteins / Q000235:genetics / Q000378:metabolism; D002940:Circadian Rhythm / Q000502:physiology*; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000235:genetics / Q000378:metabolism; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D009492:Neurospora crassa / Q000235:genetics / Q000378:metabolism; D011499:Protein Processing, Post-Translational
D029721:Drosophila Proteins; D005656:Fungal Proteins; D056926:CLOCK Proteins