Severe hyperbilirubinaemia and kernicterus: more caution is needed in newborn jaundice surveillance.
Since the 1990s, there has been a re-emergence of cases of severe hyperbilirubinaemia and kernicterus. The current UK incidence of bilirubin encephalopathy is 0.9/100,000 with a higher reported incidence in some countries. Three otherwise healthy newborn infants, who presented with severe hyperbilirubinaemia, including one who developed kernicterus, are reported here. Some of the current challenges in newborn jaundice surveillance are highlighted.
Allen
N M
NM
Department of Paediatrics, Rotunda Hospital, Dublin.
Mohammad
F
F
Foran
A
A
Corcoran
D
D
Clarke
T
T
D001663:Bilirubin / Q000097:blood; D005078:Exchange Transfusion, Whole Blood; D005260:Female; D006801:Humans; D006932:Hyperbilirubinemia / Q000175:diagnosis* / Q000628:therapy; D016756:Immunoglobulins, Intravenous; D015994:Incidence; D007231:Infant, Newborn; D007494:Ireland; D007567:Jaundice, Neonatal / Q000175:diagnosis* / Q000628:therapy; D007647:Kernicterus / Q000175:diagnosis* / Q000628:therapy; D008297:Male; D010789:Phototherapy; D011159:Population Surveillance; D012307:Risk Factors
D016756:Immunoglobulins, Intravenous; D001663:Bilirubin