title: Occupational liver injury due to N,N-dimethylformamide in the synthetics industry.
abstract: N,N-dimethylformamide (DMF) is a solvent used extensively in the chemical industry. The main toxic effect reported after exposure to DMF is hepatotoxicity. We encountered four patients with liver injury due to DMF exposure; the severity of the liver injury was related to the exposure levels. After removal of exposure, all patients recovered without specific treatment. A careful evaluation of occupational history is necessary when liver dysfunction develops in industrial workers.
authors.affiliation: Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, To-on, Japan.
authors.forename: Maho
authors.initials: M
authors.lastname: Hamada
authors.forename: Masanori
authors.initials: M
authors.lastname: Abe
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Tokumoto
authors.forename: Teruki
authors.initials: T
authors.lastname: Miyake
authors.forename: Hidehiro
authors.initials: H
authors.lastname: Murakami
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Hiasa
authors.forename: Bunzo
authors.initials: B
authors.lastname: Matsuura
authors.forename: Kohei
authors.initials: K
authors.lastname: Sato
authors.forename: Morikazu
authors.initials: M
authors.lastname: Onji
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D002617:Chemical Industry; D056486:Chemical and Drug Induced Liver Injury / Q000201:enzymology / Q000209:etiology*; D004126:Dimethylformamide; D005559:Formamides / Q000633:toxicity*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000201:enzymology / Q000209:etiology*; D016273:Occupational Exposure; D012997:Solvents / Q000633:toxicity; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D005559:Formamides; D012997:Solvents; D004126:Dimethylformamide; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase