title: Radiolytic one-electron reductive cyclization of oligodeoxynucleotides possessing a disulfide bond.
abstract: Radiolytic one-electron reduction of oligodeoxynucleotides (ODNs) possessing a disulfide bond induced strand exchange reaction in a hypoxia selective manner. In this study, we attempted to apply this radiolytic reaction to stem-and-loop structured ODNs. Hypoxic X-irradiation to an aqueous solution of stem-and-loop structured ODNs produced a cyclized DNA in good yield via an intrastrand ligation reaction.
authors.affiliation: Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Kyoto 615-8510, Japan.
authors.forename: Eiji
authors.initials: E
authors.lastname: Matsumoto
authors.forename: Kazuhito
authors.initials: K
authors.lastname: Tanabe
authors.forename: Sei-ichi
authors.initials: S
authors.lastname: Nishimoto
mesh_terms: D002851:Chromatography, High Pressure Liquid; D003500:Cyclization; D004220:Disulfides / Q000737:chemistry; D004583:Electrons; D009838:Oligodeoxyribonucleotides / Q000737:chemistry*
chemical_list: D004220:Disulfides; D009838:Oligodeoxyribonucleotides