title: 3-4'-Bipiperidines via sequential [4 + 4]-[3,3]-retro-Mannich reactions.
abstract: An approach to assembling unsymmetrically coupled piperidines is described, involving initial [4 + 4] photocycloaddition of 2-pyridones, followed by Cope rearrangement and retro-Mannich reaction. In these reactions, four stereogenic centers set during cycloaddition are relayed or erased during the subsequent steps. Two methods for retro-Mannich reaction are demonstrated.
authors.affiliation: Department of Chemistry, Temple University, 1901 North 13th Street, Philadelphia, Pennsylvania 19122, USA.
authors.forename: Peiling
authors.initials: P
authors.lastname: Chen
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Carroll
authors.forename: Scott McN
authors.initials: SM
authors.lastname: Sieburth