title: [Expression and correlation of mast cell, Clusterin/apoJ and transforming growth factor-beta in the different stages of human dermal hemangioma].
abstract: OBJECTIVE
  To investigate the expression and correlation of mast cell, Clusterin/apoJ and transforming growth factor-beta (TGF-beta) in the different stages of human dermal hemangioma.
  
  
  METHODS
  Immunohistochemical stain technique (SABC) and toluidine blue (TB) stain technique were respectively used to detect the expression level of Clusterin/apoJ and TGF-beta and the number of mast cells in the different stages of human dermal hemangioma.
  
  
  RESULTS
  There was remarkable statistical difference between the advanced stage of proliferative hemangioma and the other stages of proliferative hemangioma in the number of mast cell(P<0.01). There was also remarkable statistical difference between the early stage of involutional hemangioma and the other stages of involutional hemangioma in the number of mast cell (P<0.01). The expression of Clusterin/apoJ and TGF-beta in the advanced stage of proliferative hemangioma was significantly higher than the other stages in proliferative hemangioma (P<0.01). The expression of Clusterin/apoJ and TGF-beta in the early stage of involutional hemangioma was significantly higher than the other stages in involutional hemangioma (P<0.01). There was a significantly positive correlation between Clusterin/apoJ and TGF-beta in the different stages of human dermal hemangioma (P<0.01). The expression level of Clusterin/apoJ and TGF-beta was positively correlated with the number of mast cell in the different stages of human dermal hemangioma (P<0.01).
  
  
  CONCLUSIONS
  Mast cell may play a promotive role of apoptosis during the spontaneous regulate the expression of Clusterin/apoJ and promote the spontaneous involution of human dermal hemangioma.
authors.affiliation: Dept. of Stomatology, The Fourth Affiliated Hospital, China Medical University, Shenyang 110032, China.
authors.forename: Wei-li
authors.initials: WL
authors.lastname: Yuan
authors.forename: Xing-jun
authors.initials: XJ
authors.lastname: Qin
authors.forename: Xu-kai
authors.initials: XK
authors.lastname: Wang
mesh_terms: D017209:Apoptosis; D051152:Clusterin; D006023:Glycoproteins; D006391:Hemangioma; D006801:Humans; D008407:Mast Cells; D018832:Molecular Chaperones; D016212:Transforming Growth Factor beta
chemical_list: D051152:Clusterin; D006023:Glycoproteins; D018832:Molecular Chaperones; D016212:Transforming Growth Factor beta