title: Nephrotic syndrome as paraneoplastic manifestation of a primary pulmonary lymphoepithelioma-like carcinoma.
abstract: We present a case of nephrotic syndrome secondary to a membranous glomerulonephritis (MG), in a nonsmoking female with a solitary pulmonary nodule, which did not show growth during 2 years of followup. A biopsy by videothoracoscopy showed a granulomatous non-neoplastic process with giant multinucleated cells. The appearance of a nephrotic syndrome and its interpretation as paraneoplastic revealed the existence of a primary pulmonary lymphoepithelioma-like carcinoma (LELC), a very rare pulmonary tumor. After resection of tumor there was a complete recovery from the nephrotic syndrome. This case highlights how the investigation of paraneoplastic syndromes can help in the early diagnosis of some malignancies.
authors.affiliation: Servicio de Nefrologia, Hospital Perpetuo Socorro, Alicante, Spain. arenasd@perpertuosocorro.nehos.com
authors.forename: M D
authors.initials: MD
authors.lastname: Arenas
authors.forename: M T
authors.initials: MT
authors.lastname: Gil
authors.forename: T
authors.initials: T
authors.lastname: Malek
authors.forename: J
authors.initials: J
authors.lastname: Farré
authors.forename: F J
authors.initials: FJ
authors.lastname: Fernández Morejón
authors.forename: J M
authors.initials: JM
authors.lastname: Arriero
authors.forename: I
authors.initials: I
authors.lastname: Aranda
authors.forename: A
authors.initials: A
authors.lastname: Moledous
authors.forename: F
authors.initials: F
authors.lastname: Alvarez-Ude
mesh_terms: D002277:Carcinoma / Q000150:complications*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications*; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000209:etiology*; D010257:Paraneoplastic Syndromes / Q000209:etiology*