Inhibition of stromal cell-derived factor-1/CXCR4 axis for the cure of BCR-ABL positive chronic myeloid leukemia.
Saglio
Giuseppe
G
Division of Haematology and Internal Medicine, Department of Clinical and Biological Sciences, University of Turin, Turin, Italy. giuseppe.saglio@unito.it
Fava
Carmen
C
D000998:Antiviral Agents / Q000494:pharmacology / Q000627:therapeutic use; D001549:Benzamides; D001596:Benzylamines; D001853:Bone Marrow / Q000473:pathology; D002448:Cell Adhesion / Q000187:drug effects; D045744:Cell Line, Tumor / Q000187:drug effects / Q000201:enzymology / Q000473:pathology; D054377:Chemokine CXCL12 / Q000037:antagonists & inhibitors*; D000080027:Cyclams; D019008:Drug Resistance, Neoplasm / Q000187:drug effects; D006571:Heterocyclic Compounds / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D000068877:Imatinib Mesylate; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy*; D009363:Neoplasm Proteins / Q000037:antagonists & inhibitors*; D014411:Neoplastic Stem Cells / Q000187:drug effects / Q000378:metabolism; D010879:Piperazines / Q000494:pharmacology; D047428:Protein Kinase Inhibitors / Q000494:pharmacology; D011743:Pyrimidines / Q000494:pharmacology; D019718:Receptors, CXCR4 / Q000037:antagonists & inhibitors* / Q000737:chemistry; D055502:Secondary Prevention; D017154:Stromal Cells / Q000473:pathology
D000998:Antiviral Agents; D001549:Benzamides; D001596:Benzylamines; C515255:CXCL12 protein, human; C527276:CXCR4 protein, human; D054377:Chemokine CXCL12; D000080027:Cyclams; D006571:Heterocyclic Compounds; D009363:Neoplasm Proteins; D010879:Piperazines; D047428:Protein Kinase Inhibitors; D011743:Pyrimidines; D019718:Receptors, CXCR4; D000068877:Imatinib Mesylate; C498826:nilotinib; C088327:plerixafor