Locally advanced rectal cancer: from molecular profiling to clinical practice. A literature review: Part 2.
Colorectal cancer is the third most common cause of cancer deaths worldwide. The management of rectal cancer has undergone, and continues to undergo, significant evolutions. In the last two decades, new multimodality strategies have been developed. The ability to predict tumor response before treatment could significantly impact the selection of patients for preoperative combined-modality therapy, as well as potentially modify postoperative treatment plans. The present review analyzes the new molecular targets that could be involved in predicting response and prognosis.
Berardi
Rossana
R
Università Politecnica delle Marche, Azienda Ospedaliero-Universitaria Ospedali Riuniti Umberto I, GM Lancisi - G Salesi di Ancona, Medical Oncology Unit, 60020 Ancona, Italy. r.berardi@univpm.it
Maccaroni
Elena
E
Onofri
Azzurra
A
Giampieri
Riccardo
R
Pistelli
Mirco
M
Bittoni
Alessandro
A
Scartozzi
Mario
M
Pierantoni
Chiara
C
Mandolesi
Alessandra
A
Bearzi
Italo
I
Cascinu
Stefano
S
D000970:Antineoplastic Agents / Q000494:pharmacology*; D014408:Biomarkers, Tumor / Q000378:metabolism; D002986:Clinical Trials as Topic; D016503:Drug Delivery Systems; D006801:Humans; D011237:Predictive Value of Tests; D011379:Prognosis; D012004:Rectal Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology
D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor