title: Three-dimensional combined photoacoustic and optical coherence microscopy for in vivo microcirculation studies.
abstract: Photoacoustic microscopy is predominantly sensitive to optical absorption, while optical coherence tomography relies on optical backscattering. Integrating their complementary contrasts can provide comprehensive information about biological tissue. We have developed a dual-modality microscope that combines the two for studying microcirculation. Three-dimensional imaging of microvasculature and its local environment has been demonstrated at micrometer-order resolution using endogenous contrast in vivo.
authors.affiliation: Optical Imaging Laboratory, Department of Biomedical Engineering, Washington University in St. Louis, 1 Brookings Drive, Campus Box 1097, St. Louis, Missouri 63130, USA.
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.forename: Konstantin
authors.initials: K
authors.lastname: Maslov
authors.forename: Geng
authors.initials: G
authors.lastname: Ku
authors.forename: Lihong V
authors.initials: LV
authors.lastname: Wang
mesh_terms: D000162:Acoustics / Q000295:instrumentation*; D000818:Animals; D004423:Ear / Q000502:physiology; D051379:Mice; D008819:Mice, Nude; D008833:Microcirculation / Q000502:physiology*; D041623:Tomography, Optical Coherence / Q000379:methods*