Orchestrating twosome and foursome chromosome parties.
The conserved centromere protein C (CENP-C) is indispensable for kinetochore function. Yet its mechanism of action has remained elusive. In this issue of Developmental Cell, Tanaka et al. report that the fission yeast homolog, Cnp3, acts as a linker protein that fulfills a variety of different roles in the bi- and mono-orientation of chromosomes during mitosis and meiosis I.
Kalitsis
Paul
P
Murdoch Childrens Research Institute, Royal Children's Hospital and Melbourne University Department of Paediatrics, Parkville, Melbourne, Victoria, 3052, Australia. paul.kalitsis@mcri.edu.au
Choo
K H Andy
KH
D002503:Centromere / Q000648:ultrastructure; D002843:Chromatin / Q000378:metabolism; D002868:Chromosomal Proteins, Non-Histone / Q000737:chemistry / Q000502:physiology*; D002875:Chromosomes / Q000648:ultrastructure*; D015966:Gene Expression Regulation, Fungal; D018386:Kinetochores / Q000378:metabolism; D008540:Meiosis; D008938:Mitosis; D008954:Models, Biological; D008957:Models, Genetic; D012568:Schizosaccharomyces / Q000235:genetics / Q000502:physiology*; D029702:Schizosaccharomyces pombe Proteins / Q000235:genetics / Q000378:metabolism
D002843:Chromatin; D002868:Chromosomal Proteins, Non-Histone; D029702:Schizosaccharomyces pombe Proteins; C060905:centromere protein C