Prognostic value of CD208-positive cell infiltration in gastric cancer.
OBJECTIVE
A new marker, CD208, was recently explored as a mature interdigitating dendritic cell (DC), and the correlation between the infiltration of CD208-positive cells and clinical factors has been reported in various types of cancers. In this study, we tried to clarify the clinical implication of CD208-positive cell infiltration in gastric cancer immunohistochemically.


METHODS
A total of 128 gastric cancer patients who underwent a curative operation were enrolled. DCs in tumor nests were identified with two DC markers, CD208 and S-100 protein (S100), by immunohistochemistry. The correlation between clinicopathological features and the CD208- or S100-positive cell infiltration degree was analyzed.


RESULTS
Infiltration of S100-positive cells did not correlate with the degree of CD208-positive cell infiltration. Patients with high CD208-positive cell infiltration in the peritumor had a poorer surgical outcome than those with low CD208 infiltration (p < 0.05). Multivariate analysis revealed that CD208-positive cell infiltration was not an independent prognostic factor.


CONCLUSIONS
We showed that intratumoral CD208-positive cells, as mature DCs, had an inverse correlation to patients' postoperative outcome in gastric cancer, unlike a conventional DC marker. Evaluation of CD208-positive cell infiltration with S100-positive cell infiltration in gastric cancer is useful to predict antitumor immunological conditions in gastric cancer.
Ishigami
Sumiya
S
Kagoshima University School of Medicine, Sakuragaoka, Japan. ishiga@m.kufm.kagoshima-u.ac.jp
Ueno
Shinichi
S
Matsumoto
Masataka
M
Okumura
Hiroshi
H
Arigami
Takaaki
T
Uchikado
Yasuto
Y
Setoyama
Tetsuro
T
Arima
Hideo
H
Sasaki
Ken
K
Kitazono
Masaki
M
Shinchi
Hiroyuki
H
Kijima
Yuko
Y
Natsugoe
Shoji
S
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003713:Dendritic Cells / Q000276:immunology* / Q000378:metabolism*; D005260:Female; D006801:Humans; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology*; D051907:Lysosomal Membrane Proteins / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000378:metabolism*; D011379:Prognosis; D009418:S100 Proteins / Q000378:metabolism; D013274:Stomach Neoplasms / Q000276:immunology*; D016896:Treatment Outcome; D059666:Lysosomal-Associated Membrane Protein 3
D051907:Lysosomal Membrane Proteins; D009363:Neoplasm Proteins; D009418:S100 Proteins; C114233:LAMP3 protein, human; D059666:Lysosomal-Associated Membrane Protein 3