A unique display of toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms in non-Han Chinese Hani population.
The toll-like receptor 4 (TLR4) polymorphisms, Asp299Gly and Thr399Ile, were investigated with PCR-RFLP and DNA sequencing methods in 938 and 980 individuals from the Yunnan Hani ethnic minority and the majority Han population, respectively. Six heterozygotes for both Asp299Gly and Thr399Ile were detected in the Hani, a polymorphism frequency of 0.6397%, whereas no variants were found amongst the Han.
Zheng
B
B
Key Laboratory of Bioresources Conservation and Utilization and Human Genetics Center of Yunnan University, Kunming, China.
Wei
C
C
Shou
T
T
Li
Q
Q
Yang
M
M
Yi
L
L
Zhou
R
R
Shao
J
J
Xiao
C
C
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019943:Amino Acid Substitution / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D051197:Toll-Like Receptor 4 / Q000235:genetics*; D055815:Young Adult
C495345:TLR4 protein, human; D051197:Toll-Like Receptor 4