Establishing the follicular helper identity.
Among other genes, expression of the Bcl-6 transcriptional repressor distinguishes follicular helper T (Tfh) cells from other helper T cell subsets. In this issue of Immunity, Yu et al. (2009) demonstrate that Bcl-6 directs Tfh cell differentiation.
Kassiotis
George
G
Division of Immunoregulation, MRC National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK.
O'Garra
Anne
A
D000818:Animals; D002454:Cell Differentiation; D019070:Cell Lineage; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D015870:Gene Expression; D006801:Humans; D008221:Lymphoid Tissue / Q000166:cytology*; D051379:Mice; D051560:Proto-Oncogene Proteins c-bcl-6; D006377:T-Lymphocytes, Helper-Inducer / Q000166:cytology* / Q000276:immunology* / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*
C084103:BCL6 protein, human; C490010:Bcl6 protein, mouse; D004268:DNA-Binding Proteins; D051560:Proto-Oncogene Proteins c-bcl-6; D014157:Transcription Factors