Uterine peristalsis in women with repeated IVF failures: possible therapeutic effect of hyoscine bromide.
BACKGROUND
Uterine peristalsis, which is influenced by hormonal and cholinergic effects, may have a role in successful implantation and continuing pregnancy.


METHODS
We encountered abnormal uterine peristalsis in three women who had had repeated in vitro fertilization (IVF) treatment failures. They subsequently had successful pregnancies when hyoscine bromide was administered at the time of embryo transfer.


CONCLUSIONS
It is possible that decreasing uterine peristalsis with use of an anticholinergic agent during IVF treatment facilitates retention of embryos and increases the probability of successful pregnancy.
Kido
Aki
A
Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University, Kyoto City, Kyoto, Japan.
Togashi
Kaori
K
Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University, Kyoto City, Kyoto, Japan.
Hatayama
Hiroshi
H
Adachi Hospital, Kyoto, Kyoto, Japan.
Nakayama
Takahiro
T
Adachi Hospital, Kyoto, Kyoto, Japan.
Yamamoto
Akira
A
Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University, Kyoto City, Kyoto, Japan.
Kataoka
Masako
M
Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University, Kyoto City, Kyoto, Japan.
Tulandi
Togas
T
Department of Obstetrics and Gynecology, McGill University, Montreal QC.
D000328:Adult; D018680:Cholinergic Antagonists / Q000627:therapeutic use*; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D010528:Peristalsis / Q000187:drug effects*; D011247:Pregnancy; D012601:Scopolamine / Q000627:therapeutic use*; D017211:Treatment Failure; D014590:Uterine Contraction / Q000187:drug effects*
D018680:Cholinergic Antagonists; D012601:Scopolamine