title: Barriers to enantiocontrol in Lewis acid catalyzed hetero-Diels-Alder reactions.
abstract: Lewis bases, including reactant aldehydes, inhibit the rate of conversion for cycloaddition and those, like aldehydes or nitriles, cause a decrease in enantiocontrol due to the Lewis acidity of the activated complex.
authors.affiliation: Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA.
authors.forename: Xiaochen
authors.initials: X
authors.lastname: Wang
authors.forename: Zhuoyan
authors.initials: Z
authors.lastname: Li
authors.forename: Michael P
authors.initials: MP
authors.lastname: Doyle
mesh_terms: D000143:Acids / Q000737:chemistry; D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D009570:Nitriles / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000143:Acids; D000447:Aldehydes; D009570:Nitriles