Green tea consumption and the risk of liver cancer in Japan: the Ohsaki Cohort study.
OBJECTIVE
To investigate the association between green tea consumption and liver cancer incidence.


METHODS
We prospectively followed 41,761 Japanese adults aged 40-79 years, without a history of cancer at the baseline or any missing data for green tea consumption frequency. Cox proportional hazards models were used to calculate hazard ratios (HR) with 95% confidence intervals (CI), adjusted for age, alcohol drinking, smoking, the consumption of coffee, vegetables, dairy products, fruit, fish, and soybean.


RESULTS
Over 9 years of follow-up, among 325,947 accrued person-years, the total incidence of liver cancer was 247 cases. We found that green tea consumption was inversely associated with the incidence of liver cancer. In men, the multivariate-adjusted HRs (95% CIs) for liver cancer incidence with different green tea consumption categories were 1.00 (reference) for <1 cup/day, 0.83 (0.53-1.30) for 1-2 cups/day, 1.11 (0.73-1.68) for 3-4 cups/day, and 0.63 (0.41-0.98) for >/=5 cups/day (p for trend = 0.11). The corresponding data among women were 1.00 (reference), 0.68 (0.35-1.31), 0.79 (0.44-1.44), 0.50 (0.27-0.90) (p for trend = 0.04).


CONCLUSIONS
Green tea consumption is associated with a reduced risk of liver cancer incidence.
Ui
Akane
A
Division of Epidemiology, Department of Public Health and Forensic Medicine, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan. a5mb1008-thk@umin.ac.jp
Kuriyama
Shinichi
S
Kakizaki
Masako
M
Sone
Toshimasa
T
Nakaya
Naoki
N
Ohmori-Matsuda
Kaori
K
Hozawa
Atsushi
A
Nishino
Yoshikazu
Y
Tsuji
Ichiro
I
D000328:Adult; D000368:Aged; D001628:Beverages; D002277:Carcinoma / Q000453:epidemiology / Q000209:etiology*; D015331:Cohort Studies; D004327:Drinking Behavior / Q000502:physiology*; D004435:Eating / Q000502:physiology; D005260:Female; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D008113:Liver Neoplasms / Q000453:epidemiology / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D009749:Nutrition Surveys; D012307:Risk Factors; D013662:Tea
D013662:Tea