title: The hepatoprotective and antifibrotic effects of Saururus chinensis against carbon tetrachloride induced hepatic fibrosis in rats.
abstract: BACKGROUND
  Saururus chinensis (Lour.) Baill (Saururaceae) has been used in Chinese folk medicine for treatment of various diseases, such as edema, jaundice, gonorrhea, antipyretic, diuretic, and antiinflammatory agents.
  
  
  OBJECTIVE
  Our aim was to evaluate the hepatoprotective and antifibrotic effects of Saururus chinensis extract (SC-E) in carbon tetrachloride (CCl(4)) induced liver fibrosis rats.
  
  
  METHODS
  The SC-E (70 mg/kg) was administrated via gavage once a day starting from the onset of CCl(4) treatment (14 weeks) for subsequent 8 weeks. Evaluated with liver index, serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), hyaluronic acid (HA), hepatic malondialdehyde (MDA) content, and superoxide dismutase (SOD) activity, total cholesterol (TC), triglyceride (TG), total lipoprotein (TP), albumin (ALB), hydroxyproline (HYP), total antioxidant capacity (T-AOC), laminin (LN), type III collagen terminal peptide (PC-IIINP), and type IV collagen (IV-C), as well as with histopathologic changes of liver.
  
  
  RESULTS
  SC-E effectively reduced the elevated levels of liver index, serum ALT, AST, HA, and hepatic MDA contents, enhance the reduced hepatic SOD activity in CCl(4)-treated rats. The histopathological analysis suggested that SC-E obviously alleviated the degree of liver fibrosis induced by CCl(4).
  
  
  CONCLUSIONS
  Those results suggest SC-E has protective and therapeutic effects on liver fibrosis induced by CCl(4).
authors.affiliation: Jilin Provincial Academy of Chinese Medicine Sciences, Changchun 130021, China.
authors.forename: Lishu
authors.initials: L
authors.lastname: Wang
authors.forename: Dongyan
authors.initials: D
authors.lastname: Cheng
authors.forename: Haisheng
authors.initials: H
authors.lastname: Wang
authors.forename: Lin
authors.initials: L
authors.lastname: Di
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Zhou
authors.forename: Tunhai
authors.initials: T
authors.lastname: Xu
authors.forename: Xianwen
authors.initials: X
authors.lastname: Yang
authors.forename: Yonghong
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity*; D004195:Disease Models, Animal; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D008103:Liver Cirrhosis / Q000097:blood / Q000139:chemically induced / Q000201:enzymology / Q000473:pathology / Q000517:prevention & control*; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D032134:Saururaceae / Q000737:chemistry*
chemical_list: D010936:Plant Extracts; D002251:Carbon Tetrachloride