title: A comparison of florfenicol-flunixin meglumine versus tulathromycin for the treatment of undifferentiated fever in fall-placed feedlot calves.
abstract: The purpose of this study was to compare the efficacy of a new combination drug, florfenicol-flunixin meglumine, with tulathromycin for initial treatment of undifferentiated fever (UF) in fall-placed calves that received metaphylactic tilmicosin on arrival at the feedlot. No significant differences were observed in UF relapses between the two drugs. Calves treated with florfenicol-flunixin had a lower crude case fatality rate (P = .0447) than calves treated with tulathromycin but did not have a significantly lower respiratory disease and histophilosis case fatality rate (P = .12). Whether the new florfenicol-flunixin product is more cost-effective than tulathromycin for the treatment of UF in fall-placed feedlot calves will depend on how the new product is priced in the marketplace relative to tulathromycin.
authors.affiliation: Alberta Beef Health Solutions Inc., Picture Butte, Alberta, Canada. donkersg@telus.net
authors.forename: Joyce
authors.initials: J
authors.lastname: Van Donkersgoed
authors.forename: Janice
authors.initials: J
authors.lastname: Berg
authors.forename: Steven
authors.initials: S
authors.lastname: Hendrick
mesh_terms: D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000627:therapeutic use*; D000822:Animal Husbandry; D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy*; D003002:Clonixin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004187:Disaccharides / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D005334:Fever / Q000188:drug therapy / Q000401:mortality / Q000662:veterinary*; D006571:Heterocyclic Compounds / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D012621:Seasons; D013839:Thiamphenicol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D018942:Macrolides
chemical_list: D018712:Analgesics, Non-Narcotic; D003002:Clonixin; D004187:Disaccharides; D006571:Heterocyclic Compounds; D013839:Thiamphenicol; C014558:flunixin meglumine; C035534:florfenicol; C485204:tulathromycin; D018942:Macrolides