title: The effectiveness of Proctofoam-HC for treatment of hemorrhoids in late pregnancy.
abstract: OBJECTIVE
  Currently no topical anti-hemorrhoidal agents have been studied for effectiveness in pregnancy. This study evaluated the effectiveness of Proctofoam-HC used during the last trimester of pregnancy.
  
  
  METHODS
  In this prospective, open-label, observational study, pregnant women prescribed Proctofoam-HC were asked to complete two telephone interview questionnaires.
  
  
  RESULTS
  A total of 88 women completed the study. All hemorrhoidal symptoms, including pain, pruritus, swelling, itching, decreased significantly (P < 0.001) and overall well-being improved. The improvement was clinically very significant after correction for potential placebo effect.
  
  
  CONCLUSIONS
  Proctofoam-HC appears to provide effective treatment of hemorrhoids in late pregnancy.
authors.affiliation: The Motherisk Program, Hospital for Sick Children, Toronto, ON, Canada.
authors.forename: Sabina
authors.initials: S
authors.lastname: Vohra
authors.forename: Hani
authors.initials: H
authors.lastname: Akoury
authors.forename: Paul
authors.initials: P
authors.lastname: Bernstein
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Einarson
authors.forename: Nicholas
authors.initials: N
authors.lastname: Pairaudeau
authors.forename: Anna
authors.initials: A
authors.lastname: Taddio
authors.forename: Gideon
authors.initials: G
authors.lastname: Koren
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D004338:Drug Combinations; D005260:Female; D006484:Hemorrhoids / Q000188:drug therapy*; D006801:Humans; D006854:Hydrocortisone / Q000627:therapeutic use*; D009025:Morpholines / Q000627:therapeutic use*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D011446:Prospective Studies
chemical_list: D000893:Anti-Inflammatory Agents; D004338:Drug Combinations; D009025:Morpholines; C009046:proctofoam-HC; D006854:Hydrocortisone