title: Anti-inflammatory activity of a HPLC-fingerprinted aqueous infusion of aerial part of Bidens tripartita L.
abstract: The anti-inflammatory potential of three doses of an aqueous infusion of aerial parts Bidens tripartita L. against carrageenan-induced acute paw edema in rats was investigated. A phytochemical study and qualitative-quantitative analyses revealed the presence of flavonoids, tannins, polysaccharides, phenols, amino acids, ascorbic acid, organic acids and polyacetylenes. Infusion doses of 20ml/kgbody wt. exhibited significant anti-inflammatory activity in rats, as compared with indomethacin. In addition, the infusion showed analgesic properties in a hot-plate test and antipyretic properties in carrageenan-induced local hyperthermia, both in rats. The effects were dose-dependent. Our results provide evidence for the potential usefulness of B. tripartita infusion in the treatment of inflammatory disorders.
authors.affiliation: Interregional Fund Adaptation, 1, Ushakova, 188800, Vyborg, Leningrad Region, Russia.
authors.forename: O N
authors.initials: ON
authors.lastname: Pozharitskaya
authors.forename: A N
authors.initials: AN
authors.lastname: Shikov
authors.forename: M N
authors.initials: MN
authors.lastname: Makarova
authors.forename: V M
authors.initials: VM
authors.lastname: Kosman
authors.forename: N M
authors.initials: NM
authors.lastname: Faustova
authors.forename: S V
authors.initials: SV
authors.lastname: Tesakova
authors.forename: V G
authors.initials: VG
authors.lastname: Makarov
authors.forename: B
authors.initials: B
authors.lastname: Galambosi
mesh_terms: D000700:Analgesics / Q000032:analysis / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000032:analysis / Q000494:pharmacology / Q000627:therapeutic use*; D031176:Bidens / Q000737:chemistry*; D002351:Carrageenan; D002851:Chromatography, High Pressure Liquid; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D005260:Female; D005334:Fever / Q000139:chemically induced / Q000188:drug therapy*; D006358:Hot Temperature; D007213:Indomethacin; D010146:Pain / Q000188:drug therapy*; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D002351:Carrageenan; D007213:Indomethacin