title: Splenic hemangiomatosis. A report of two cases and review of literature.
abstract: Splenic vascular tumors represent a wide spectrum of lesions, ranging from benign to highly aggressive neoplasms. Among benign tumors, localized hemangiomas are the most frequent. Splenic hemangiomatosis is currently considered a diffuse variant of hemangioma, characterized by total or subtotal replacement of the splenic parenchyma by a vascular proliferation featuring the usual morphological findings of hemangioma. To the best of our knowledge based on a review of the medical literature, less than twenty cases have been described. Moreover, pediatric cases are absolutely exceptional. We report two new cases of splenic hemangiomatosis respectively occurring in a 1-year-old child and in a 30-year-old woman, with particular attention to the histological and immunohistochemical findings; related problems of differential diagnosis are also discussed.
authors.affiliation: Unità Operativa di Anatomia Patologica, Azienda Ospedaliera di rilievo nazionale "A. Cardarelli", Via A. Cardarelli 9, 80131 Napoli, Italy. ada66@inwind.it
authors.forename: Antonio
authors.initials: A
authors.lastname: D'Antonio
authors.forename: Amedeo
authors.initials: A
authors.lastname: Boscaino
authors.forename: Gianfranco
authors.initials: G
authors.lastname: De Dominicis
authors.forename: Oscar
authors.initials: O
authors.lastname: Nappi
mesh_terms: D000328:Adult; D018952:Antigens, CD34 / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis; D003560:Cysts / Q000175:diagnosis; D003937:Diagnosis, Differential; D005169:Factor VIII / Q000032:analysis; D005260:Female; D006222:Hamartoma / Q000175:diagnosis; D006391:Hemangioma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D006394:Hemangiosarcoma / Q000175:diagnosis; D006801:Humans; D007223:Infant; D008202:Lymphangioma / Q000175:diagnosis; D008204:Lymphangiosarcoma / Q000175:diagnosis; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000032:analysis; D013154:Spleen / Q000737:chemistry / Q000473:pathology*; D013160:Splenic Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery
chemical_list: D018952:Antigens, CD34; D014408:Biomarkers, Tumor; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D005169:Factor VIII