title: Seizure control with thermal energy? Modeling of heat diffusivity in brain tissue and computer-based design of a prototype mini-cooler.
abstract: Automated seizure blockage is a top priority in epileptology. Lowering nervous tissue temperature below a certain level suppresses abnormal neuronal activity, an approach with certain advantages over electrical stimulation, the preferred investigational therapy for pharmacoresistant seizures. A computer model was developed to identify an efficient probe design and parameters that would allow cooling of brain tissue by no less than 21 degrees C in 30s, maximum. The Pennes equation and the computer code ABAQUS were used to investigate the spatiotemporal behavior of heat diffusivity in brain tissue. Arrays of distributed probes deliver sufficient thermal energy to decrease, inhomogeneously, brain tissue temperature from 37 to 20 degrees C in 30s and from 37 to 15 degrees C in 60s. Tissue disruption/loss caused by insertion of this probe is considerably less than that caused by ablative surgery. This model may be applied for the design and development of cooling devices for seizure control.
authors.affiliation: University of Kansas Medical Center, Kansas City, KS, USA. iosorio@kumc.edu
authors.forename: Ivan
authors.initials: I
authors.lastname: Osorio
authors.forename: Fon-Chieh
authors.initials: FC
authors.lastname: Chang
authors.forename: Nachappa
authors.initials: N
authors.lastname: Gopalsami
mesh_terms: D000818:Animals; D001833:Body Temperature Regulation / Q000502:physiology; D001921:Brain / Q000503:physiopathology*; D003080:Cold Temperature; D003198:Computer Simulation; D017076:Computer-Aided Design / Q000295:instrumentation; D006801:Humans; D008954:Models, Biological; D015203:Reproducibility of Results; D012640:Seizures / Q000473:pathology* / Q000503:physiopathology*; D013814:Thermal Conductivity