title: Small kinase assay panels can provide a measure of selectivity.
abstract: In this Letter, a novel strategy for assessment of ligand promiscuity is described. By using a carefully selected small set of kinases together with multivariate statistical methods, a measure of selectivity can be estimated. This will facilitate an appropriate selection of compounds for further development in lead generation and optimization.
authors.affiliation: Beactica AB, Box 567, SE-751 22 Uppsala, Sweden. Peter.Brandt@beactica.com
authors.forename: Peter
authors.initials: P
authors.lastname: Brandt
authors.forename: Annika Jenmalm
authors.initials: AJ
authors.lastname: Jensen
authors.forename: Jonas
authors.initials: J
authors.lastname: Nilsson
mesh_terms: D015195:Drug Design; D057075:Enzyme Assays; D016018:Least-Squares Analysis; D008024:Ligands; D015999:Multivariate Analysis; D025341:Principal Component Analysis; D047428:Protein Kinase Inhibitors / Q000737:chemistry*; D011494:Protein Kinases / Q000737:chemistry* / Q000378:metabolism
chemical_list: D008024:Ligands; D047428:Protein Kinase Inhibitors; D011494:Protein Kinases