title: In vivo activity of a novel anti-methicillin-resistant Staphylococcus aureus cephalosporin, ceftaroline, against vancomycin-susceptible and -resistant Enterococcus faecalis strains in a rabbit endocarditis model: a comparative study with linezolid and vancomycin.
abstract: We assessed the in vitro and in vivo efficacy of the novel parenteral broad-spectrum cephalosporin ceftaroline against Enterococcus faecalis in time-kill experiments and in a rabbit endocarditis model with simulated human dosing. Ceftaroline was more active than either vancomycin or linezolid against vancomycin-sensitive and -resistant isolates of E. faecalis.
authors.affiliation: Université de Nantes, Nantes Atlantique Universités, Thérapeutiques Cliniques et Expérimentales des Infections, UFR Médecine, Nantes, France.
authors.forename: Cédric
authors.initials: C
authors.lastname: Jacqueline
authors.forename: Jocelyne
authors.initials: J
authors.lastname: Caillon
authors.forename: Virginie
authors.initials: V
authors.lastname: Le Mabecque
authors.forename: Anne-Françoise
authors.initials: AF
authors.lastname: Miègeville
authors.forename: Yigong
authors.initials: Y
authors.lastname: Ge
authors.forename: Donald
authors.initials: D
authors.lastname: Biek
authors.forename: Eric
authors.initials: E
authors.lastname: Batard
authors.forename: Gilles
authors.initials: G
authors.lastname: Potel
mesh_terms: D000081:Acetamides / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D002511:Cephalosporins / Q000494:pharmacology* / Q000627:therapeutic use*; D004697:Endocarditis, Bacterial / Q000188:drug therapy / Q000382:microbiology; D013293:Enterococcus faecalis / Q000187:drug effects*; D000069349:Linezolid; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D023303:Oxazolidinones / Q000494:pharmacology / Q000627:therapeutic use; D011817:Rabbits; D014640:Vancomycin / Q000494:pharmacology / Q000627:therapeutic use; D020713:Vancomycin Resistance / Q000187:drug effects; D000097583:Ceftaroline
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D000069349:Linezolid; D023303:Oxazolidinones; D014640:Vancomycin; D000097583:Ceftaroline