DNA vaccines against influenza viruses.
As an attractive alternative to conventional vaccines, DNA vaccines play a critical role in inducing protection against several infectious diseases. In this review, we discuss the advantages that DNA vaccines offer in comparison to conventional protein-based vaccines. We discuss strategies to improve the potency and efficacy of DNA vaccines. Specifically, we focus on the potential use of DNA-based vaccines to elicit broad-spectrum humoral and cellular immunity against influenza virus. Finally, we discuss the advances made in the use of DNA vaccines to prevent avian H5N1 influenza.
Kim
Jin Hyang
JH
Department of Microbiology & Immunology and Emory Vaccine Center, School of Medicine, Emory University, 954 Gatewood Road, Atlanta, GA 30329, USA.
Jacob
Joshy
J
D000818:Animals; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology*; D053124:Influenza A Virus, H5N1 Subtype / Q000276:immunology*; D007252:Influenza Vaccines / Q000276:immunology*; D019444:Vaccines, DNA / Q000276:immunology*
D007252:Influenza Vaccines; D019444:Vaccines, DNA