Synthesis and properties of new RNA molecules incorporating 2'-O-aryluridine derivatives.
A variety of 2'-O-arylnucleosides with functional groups were synthesized by the microwave-assisted reaction of 2,2'-anhydrouridine with phenol derivatives. The 2'-O-arylnucleosides thus obtained were incorporated into 2'-O-Me RNA or DNA oligomers and their hybridization properties were studied by T(m) measurements.
Oeda
Yusuke
Y
Department of Life Science, Graduate School of Bioscience and Technology, Tokyo Institute of Technology, Yokohama 226-8501, Japan.
Iijima
Yoshihiro
Y
Tsunoda
Hirosuke
H
Okubo
Akihiro
A
Seio
Kohji
K
Sekine
Mitsuo
M
D004247:DNA / Q000737:chemistry; D009705:Nucleosides / Q000138:chemical synthesis / Q000737:chemistry; D012313:RNA / Q000138:chemical synthesis / Q000737:chemistry*; D014529:Uridine / Q000031:analogs & derivatives* / Q000737:chemistry
D009705:Nucleosides; D012313:RNA; D004247:DNA; D014529:Uridine