Fluorescent glycan derivatives: their use for natural glycan microarrays.
Glycan microarrays have become powerful tools in the investigation of biological systems because they enable fast, quantitative, and simultaneous analysis of glycan-protein interactions with small quantities of samples. One hurdle in the construction of glycan microarrays is to obtain a diverse set of glycans for immobilization on surfaces. An article in this issue of ACS Chemical Biology describes the microscale preparation of fluorescently labeled reactive glycans in a cyclic form of the reducing sugar, from natural sources, that can be utilized directly to create natural glycan microarrays for use in functional glycomics.
Park
Sungjin
S
Department of Chemistry, Yonsei University, Seoul 120-749, Korea. injae@yonsei.ac.kr
Sung
Jung-Won
JW
Shin
Injae
I
D005456:Fluorescent Dyes / Q000032:analysis*; D054794:Glycomics / Q000379:methods; D011134:Polysaccharides / Q000032:analysis* / Q000378:metabolism; D040081:Protein Array Analysis / Q000379:methods*; D011485:Protein Binding; D011506:Proteins / Q000032:analysis / Q000378:metabolism*
D005456:Fluorescent Dyes; D011134:Polysaccharides; D011506:Proteins