Screening and evaluation of antioxidant activity of some amido-carbonyl oxime derivatives and their radical scavenging activities.
The antioxidant activity of some amido-carbonyl oximes containing a C=O and -NH-R adjacent to the oxime group, [Phenyl-C(=O)-C(=N-OH)-N(-H)-Phenyl(-R)] where R= H, 4-chloro, 4-methyl, 4-methoxy, 3,4-dichloro, 3,4-dimethyl, 3-chloro-4-dimethyl, 3-chloro-4-methoxy, naphthyl and an amido-carbonyl dioxime were investigated in vitro by ferric thiocyanate, total reducing power by potassium ferricyanide reduction, 1,1-diphenyl-2- picryl-hydrazyl (DPPH(.)) free radical scavenging, ferrous ions chelating, superoxide anion radical scavenging and hydrogen peroxide scavenging activity assays. The results indicated that the amido-carbonyl oximes have powerful antioxidant capacity.
Ozen
Tevfik
T
Department of Chemistry, Arts and Sciences Faculty, Giresun University, TR-28049 Giresun, Turkey. ozentevfik@hotmail.com
Taş
Murat
M
D000577:Amides / Q000138:chemical synthesis / Q000737:chemistry*; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry*; D016166:Free Radical Scavengers / Q000138:chemical synthesis / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010091:Oximes / Q000138:chemical synthesis / Q000737:chemistry*
D000577:Amides; D000975:Antioxidants; D016166:Free Radical Scavengers; D010091:Oximes