title: Serum complement-reactive protein (CRP) trends following local and free-tissue reconstructions for traumatic injuries or chronic wounds of the lower limb.
abstract: BACKGROUND
  Soft-tissue reconstructions of the lower limb for open fractures, chronic infections and nonunion carry a high risk of infection, nonunion, osteomyelitis and amputation. Inflammatory markers can be difficult to interpret in the context of recent surgery and trauma and little is known of their behaviour.
  
  
  OBJECTIVE
  To profile the behaviour of complement-reactive protein (CRP) following soft-tissue reconstructions for the lower limb performed for acute injuries(open fractures) and chronic wounds(nonunion and osteomyelitis).
  
  
  METHODS
  Patients who had soft-tissue reconstructions following open fractures of the lower limbs, chronic infection, osteomyelitis and nonunion were identified and their notes and postoperative CRP levels reviewed.
  
  
  RESULTS
  52 patients were identified. 41 reached peak CRP < or =4 days of surgery. A peak CRP >4 days indicated infection or further surgery (p<0.01). Acute and chronic groups showed a peak in mean CRP at day 2. Chronic wound patients showed significantly elevated CRP levels compared to acute wound patients at day 7 (p=0.05) and 8 (p<0.001). Muscle and fasciocutaneous flaps showed similar CRP profiles. Patients with nonunion or deep infections showed persistently elevated CRP levels.
  
  
  CONCLUSIONS
  CRP peaks on day 2 following soft-tissue coverage and falls thereafter. Peaks after day 4 indicate infective complications or further surgery. Patients with chronic wounds show a slower decrease in their CRP. Persistently elevated CRP following surgery is associated with infection and nonunion.
authors.affiliation: Department of Plastic and Reconstructive Surgery Frenchay Hospital, Bristol, UK.
authors.forename: E H
authors.initials: EH
authors.lastname: Wright
authors.forename: U
authors.initials: U
authors.lastname: Khan
mesh_terms: D000208:Acute Disease; D015415:Biomarkers / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism*; D002908:Chronic Disease; D005597:Fractures, Open / Q000097:blood* / Q000601:surgery*; D006801:Humans; D007869:Leg Injuries / Q000097:blood* / Q000601:surgery*; D010019:Osteomyelitis / Q000097:blood* / Q000601:surgery*; D019651:Plastic Surgery Procedures / Q000379:methods*; D017695:Soft Tissue Injuries / Q000097:blood* / Q000601:surgery*; D013524:Surgical Flaps
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein