title: Evaluation of water treatment plant UV reactor efficiency against Cryptosporidium parvum oocyst infectivity in immunocompetent suckling mice.
abstract: OBJECTIVE
  To assess the efficiency of a medium-pressure UV reactor under full-scale water treatment plant (WTP) conditions on the infectivity of Cryptosporidium parvum oocysts in an Naval Medical Research Institute (NMRI) suckling mice infectivity model.
  
  
  RESULTS
  Six/seven-day-old mice were administered orally 2-10x10(4)Cryptosporidium parvum oocysts. Compared with nonirradiated oocysts, 40 mJ cm(-2) UV irradiation of ingested oocysts resulted 7 days later in a 3.4-4.0 log10 reduction in the counts of small intestine oocysts, using a fluorescent flow cytometry assay.
  
  
  CONCLUSIONS
  Present data extend to industrial conditions previous observations of the efficiency of UV irradiation against Cryptosporidium parvum oocyst in vivo development.
  
  
  CONCLUSIONS
  Present results suggest that in WTP conditions, a medium-pressure UV reactor is efficient in reducing the infectivity of Cryptosporidium parvum oocysts, one of the most resistant micro-organisms present in environmental waters.
authors.affiliation:  Parasitology Department, Rouen University Hospital & EA 4311-IFRMP 23, Faculty of Medicine and Pharmacy, University of Rouen, Rouen Cedex, France.
authors.forename: L
authors.initials: L
authors.lastname: Le Goff
authors.affiliation:  Parasitology Department, Rouen University Hospital & EA 4311-IFRMP 23, Faculty of Medicine and Pharmacy, University of Rouen, Rouen Cedex, France.
authors.forename: S
authors.initials: S
authors.lastname: Khaldi
authors.affiliation:  Parasitology Department, Rouen University Hospital & EA 4311-IFRMP 23, Faculty of Medicine and Pharmacy, University of Rouen, Rouen Cedex, France.
authors.forename: L
authors.initials: L
authors.lastname: Favennec
authors.affiliation:  STEREAU Process and Technologies, St-Quentin-en-Yvelines, France.
authors.forename: F
authors.initials: F
authors.lastname: Nauleau
authors.affiliation:  Laboratory of Parasitology-Mycology, EA 3520 Faculty of Medicine Paris Diderot, Paris, France.
authors.forename: P
authors.initials: P
authors.lastname: Meneceur
authors.affiliation:  STEREAU Process and Technologies, St-Quentin-en-Yvelines, France.
authors.forename: J
authors.initials: J
authors.lastname: Perot
authors.affiliation:  Immunology Department, Caen University Hospital & UPRES-EA 2128, Faculty of Medicine, University of Caen, Caen Cedex, France.
authors.forename: J-J
authors.initials: JJ
authors.lastname: Ballet
authors.affiliation:  Parasitology Department, Rouen University Hospital & EA 4311-IFRMP 23, Faculty of Medicine and Pharmacy, University of Rouen, Rouen Cedex, France.
authors.forename: G
authors.initials: G
authors.lastname: Gargala
mesh_terms: D000818:Animals; D000833:Animals, Suckling; D016785:Cryptosporidium parvum / Q000254:growth & development / Q000472:pathogenicity / Q000528:radiation effects*; D005434:Flow Cytometry; D051379:Mice; D033661:Oocysts / Q000528:radiation effects*; D011312:Pressure; D014871:Water Microbiology; D018508:Water Purification / Q000379:methods*