title: A novel picornavirus associated with gastroenteritis.
abstract: A novel picornavirus genome was sequenced, showing 42.6%, 35.2%, and 44.6% of deduced amino acid identities corresponding to the P1, P2, and P3 regions, respectively, of the Aichi virus. Divergent strains of this new virus, which we named salivirus, were detected in 18 stool samples from Nigeria, Tunisia, Nepal, and the United States. A statistical association was seen between virus shedding and unexplained cases of gastroenteritis in Nepal (P = 0.0056). Viruses with approximately 90% nucleotide similarity, named klassevirus, were also recently reported in three cases of unexplained diarrhea from the United States and Australia and in sewage from Spain, reflecting a global distribution and supporting a pathogenic role for this new group of picornaviruses.
authors.affiliation: Blood Systems Research Institute, San Francisco, CA 94118, USA.
authors.forename: Linlin
authors.initials: L
authors.lastname: Li
authors.forename: Joseph
authors.initials: J
authors.lastname: Victoria
authors.forename: Amit
authors.initials: A
authors.lastname: Kapoor
authors.forename: Olga
authors.initials: O
authors.lastname: Blinkova
authors.forename: Chunlin
authors.initials: C
authors.lastname: Wang
authors.forename: Farbod
authors.initials: F
authors.lastname: Babrzadeh
authors.forename: Carl J
authors.initials: CJ
authors.lastname: Mason
authors.forename: Prativa
authors.initials: P
authors.lastname: Pandey
authors.forename: Hinda
authors.initials: H
authors.lastname: Triki
authors.forename: Olfa
authors.initials: O
authors.lastname: Bahri
authors.forename: Bamidele Soji
authors.initials: BS
authors.lastname: Oderinde
authors.forename: Marycelin Mandu
authors.initials: MM
authors.lastname: Baba
authors.forename: David Nadeba
authors.initials: DN
authors.lastname: Bukbuk
authors.forename: John M
authors.initials: JM
authors.lastname: Besser
authors.forename: Joanne M
authors.initials: JM
authors.lastname: Bartkus
authors.forename: Eric L
authors.initials: EL
authors.lastname: Delwart
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D005759:Gastroenteritis / Q000821:virology*; D016679:Genome, Viral / Q000235:genetics; D006801:Humans; D008969:Molecular Sequence Data; D010802:Phylogeny; D010849:Picornaviridae / Q000235:genetics*; D010850:Picornaviridae Infections / Q000821:virology*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014764:Viral Proteins / Q000235:genetics
chemical_list: D014764:Viral Proteins