title: Identification of seven new prostate cancer susceptibility loci through a genome-wide association study.
abstract: Prostate cancer (PrCa) is the most frequently diagnosed cancer in males in developed countries. To identify common PrCa susceptibility alleles, we previously conducted a genome-wide association study in which 541,129 SNPs were genotyped in 1,854 PrCa cases with clinically detected disease and in 1,894 controls. We have now extended the study to evaluate promising associations in a second stage in which we genotyped 43,671 SNPs in 3,650 PrCa cases and 3,940 controls and in a third stage involving an additional 16,229 cases and 14,821 controls from 21 studies. In addition to replicating previous associations, we identified seven new prostate cancer susceptibility loci on chromosomes 2, 4, 8, 11 and 22 (with P = 1.6 x 10(-8) to P = 2.7 x 10(-33)).
authors.affiliation: The Institute of Cancer Research, Sutton, Surrey, UK.
authors.forename: Rosalind A
authors.initials: RA
authors.lastname: Eeles
authors.forename: Zsofia
authors.initials: Z
authors.lastname: Kote-Jarai
authors.forename: Ali Amin
authors.initials: AA
authors.lastname: Al Olama
authors.forename: Graham G
authors.initials: GG
authors.lastname: Giles
authors.forename: Michelle
authors.initials: M
authors.lastname: Guy
authors.forename: Gianluca
authors.initials: G
authors.lastname: Severi
authors.forename: Kenneth
authors.initials: K
authors.lastname: Muir
authors.forename: John L
authors.initials: JL
authors.lastname: Hopper
authors.forename: Brian E
authors.initials: BE
authors.lastname: Henderson
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Haiman
authors.forename: Johanna
authors.initials: J
authors.lastname: Schleutker
authors.forename: Freddie C
authors.initials: FC
authors.lastname: Hamdy
authors.forename: David E
authors.initials: DE
authors.lastname: Neal
authors.forename: Jenny L
authors.initials: JL
authors.lastname: Donovan
authors.forename: Janet L
authors.initials: JL
authors.lastname: Stanford
authors.forename: Elaine A
authors.initials: EA
authors.lastname: Ostrander
authors.forename: Sue A
authors.initials: SA
authors.lastname: Ingles
authors.forename: Esther M
authors.initials: EM
authors.lastname: John
authors.forename: Stephen N
authors.initials: SN
authors.lastname: Thibodeau
authors.forename: Daniel
authors.initials: D
authors.lastname: Schaid
authors.forename: Jong Y
authors.initials: JY
authors.lastname: Park
authors.forename: Amanda
authors.initials: A
authors.lastname: Spurdle
authors.forename: Judith
authors.initials: J
authors.lastname: Clements
authors.forename: Joanne L
authors.initials: JL
authors.lastname: Dickinson
authors.forename: Christiane
authors.initials: C
authors.lastname: Maier
authors.forename: Walther
authors.initials: W
authors.lastname: Vogel
authors.forename: Thilo
authors.initials: T
authors.lastname: Dörk
authors.forename: Timothy R
authors.initials: TR
authors.lastname: Rebbeck
authors.forename: Kathleen A
authors.initials: KA
authors.lastname: Cooney
authors.forename: Lisa
authors.initials: L
authors.lastname: Cannon-Albright
authors.forename: Pierre O
authors.initials: PO
authors.lastname: Chappuis
authors.forename: Pierre
authors.initials: P
authors.lastname: Hutter
authors.forename: Maurice
authors.initials: M
authors.lastname: Zeegers
authors.forename: Radka
authors.initials: R
authors.lastname: Kaneva
authors.forename: Hong-Wei
authors.initials: HW
authors.lastname: Zhang
authors.forename: Yong-Jie
authors.initials: YJ
authors.lastname: Lu
authors.forename: William D
authors.initials: WD
authors.lastname: Foulkes
authors.forename: Dallas R
authors.initials: DR
authors.lastname: English
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Leongamornlert
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Tymrakiewicz
authors.forename: Jonathan
authors.initials: J
authors.lastname: Morrison
authors.forename: Audrey T
authors.initials: AT
authors.lastname: Ardern-Jones
authors.forename: Amanda L
authors.initials: AL
authors.lastname: Hall
authors.forename: Lynne T
authors.initials: LT
authors.lastname: O'Brien
authors.forename: Rosemary A
authors.initials: RA
authors.lastname: Wilkinson
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Saunders
authors.forename: Elizabeth C
authors.initials: EC
authors.lastname: Page
authors.forename: Emma J
authors.initials: EJ
authors.lastname: Sawyer
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Edwards
authors.forename: David P
authors.initials: DP
authors.lastname: Dearnaley
authors.forename: Alan
authors.initials: A
authors.lastname: Horwich
authors.forename: Robert A
authors.initials: RA
authors.lastname: Huddart
authors.forename: Vincent S
authors.initials: VS
authors.lastname: Khoo
authors.forename: Christopher C
authors.initials: CC
authors.lastname: Parker
authors.forename: Nicholas
authors.initials: N
authors.lastname: Van As
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Woodhouse
authors.forename: Alan
authors.initials: A
authors.lastname: Thompson
authors.forename: Tim
authors.initials: T
authors.lastname: Christmas
authors.forename: Chris
authors.initials: C
authors.lastname: Ogden
authors.forename: Colin S
authors.initials: CS
authors.lastname: Cooper
authors.forename: Melissa C
authors.initials: MC
authors.lastname: Southey
authors.forename: Artitaya
authors.initials: A
authors.lastname: Lophatananon
authors.forename: Jo-Fen
authors.initials: JF
authors.lastname: Liu
authors.forename: Laurence N
authors.initials: LN
authors.lastname: Kolonel
authors.forename: Loic
authors.initials: L
authors.lastname: Le Marchand
authors.forename: Tiina
authors.initials: T
authors.lastname: Wahlfors
authors.forename: Teuvo L
authors.initials: TL
authors.lastname: Tammela
authors.forename: Anssi
authors.initials: A
authors.lastname: Auvinen
authors.forename: Sarah J
authors.initials: SJ
authors.lastname: Lewis
authors.forename: Angela
authors.initials: A
authors.lastname: Cox
authors.forename: Liesel M
authors.initials: LM
authors.lastname: FitzGerald
authors.forename: Joseph S
authors.initials: JS
authors.lastname: Koopmeiners
authors.forename: Danielle M
authors.initials: DM
authors.lastname: Karyadi
authors.forename: Erika M
authors.initials: EM
authors.lastname: Kwon
authors.forename: Mariana C
authors.initials: MC
authors.lastname: Stern
authors.forename: Roman
authors.initials: R
authors.lastname: Corral
authors.forename: Amit D
authors.initials: AD
authors.lastname: Joshi
authors.forename: Ahva
authors.initials: A
authors.lastname: Shahabi
authors.forename: Shannon K
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authors.lastname: McDonnell
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Sellers
authors.forename: Julio
authors.initials: J
authors.lastname: Pow-Sang
authors.forename: Suzanne
authors.initials: S
authors.lastname: Chambers
authors.forename: Joanne
authors.initials: J
authors.lastname: Aitken
authors.forename: R A Frank
authors.initials: RA
authors.lastname: Gardiner
authors.forename: Jyotsna
authors.initials: J
authors.lastname: Batra
authors.forename: Mary Anne
authors.initials: MA
authors.lastname: Kedda
authors.forename: Felicity
authors.initials: F
authors.lastname: Lose
authors.forename: Andrea
authors.initials: A
authors.lastname: Polanowski
authors.forename: Briony
authors.initials: B
authors.lastname: Patterson
authors.forename: Jürgen
authors.initials: J
authors.lastname: Serth
authors.forename: Andreas
authors.initials: A
authors.lastname: Meyer
authors.forename: Manuel
authors.initials: M
authors.lastname: Luedeke
authors.forename: Klara
authors.initials: K
authors.lastname: Stefflova
authors.forename: Anna M
authors.initials: AM
authors.lastname: Ray
authors.forename: Ethan M
authors.initials: EM
authors.lastname: Lange
authors.forename: Jim
authors.initials: J
authors.lastname: Farnham
authors.forename: Humera
authors.initials: H
authors.lastname: Khan
authors.forename: Chavdar
authors.initials: C
authors.lastname: Slavov
authors.forename: Atanaska
authors.initials: A
authors.lastname: Mitkova
authors.forename: Guangwen
authors.initials: G
authors.lastname: Cao
authors.forename: Douglas F
authors.initials: DF
authors.lastname: Easton
mesh_terms: D002877:Chromosomes, Human; D004198:Disease Susceptibility; D015894:Genome, Human; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms / Q000235:genetics*