Cisplatin-based chemotherapy: Add high-frequency audiometry in the regimen.
BACKGROUND
Cisplatin-induced ototoxicity shows high interindividual variability and is often accompanied by transient or permanent tinnitus. It is not possible to identify the susceptible individuals before commencement of the treatment. We conducted a prospective, randomized and observational study in a tertiary care centre and evaluated the effects of different doses of cisplatin on hearing.


METHODS
Fifty-seven patients scheduled for cisplatin-based chemotherapy were included in the study. All patients were divided into three groups depending on the dose of cisplatin infused in 3 weeks.


RESULTS
The subjective hearing loss was found in seven patients, while six patients had tinnitus during the chemotherapy. The hearing loss was sensorineural, dose dependent, symmetrical, bilateral and irreversible. Higher frequencies were first to be affected in cisplatin chemotherapy.


CONCLUSIONS
As use of high-frequency audiometry is still limited in research work only, we need a strict protocol of adding high-frequency audiometry in the cisplatin-based chemotherapy regimen.
Arora
R
R
Departments of Otorhinolaryngology-Head and Neck Surgery, I G Medical College, Shimla, India.
Thakur
J S
JS
Azad
R K
RK
Mohindroo
N K
NK
Sharma
D R
DR
Seam
R K
RK
D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001299:Audiometry; D002945:Cisplatin / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D005260:Female; D034381:Hearing Loss / Q000139:chemically induced*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000188:drug therapy; D014012:Tinnitus / Q000139:chemically induced*; D055815:Young Adult
D000970:Antineoplastic Agents; D002945:Cisplatin