title: Neuropsychological functioning in early-onset first-episode psychosis: comparison of diagnostic subgroups.
abstract: The aims of this study were to examine the nature and extent of cognitive impairment in first-episode early-onset psychosis (FE-EOP) soon after their stabilisation and to search for potential differences according to specific diagnostic sub-groups of patients. As part of a Spanish multicentre longitudinal study, 107 FE-EOP patients and 98 healthy controls were assessed on the following cognitive domains: attention, working memory, executive functioning, and verbal learning and memory. Three diagnostic categories were established in the patient sample: schizophrenia (n = 36), bipolar disorder (n = 19), and other psychosis (n = 52). Patients performed significantly worse than controls in all cognitive domains. The three diagnostic sub-groups did not differ in terms of impaired/preserved cognitive functions or degree of impairment. FE-EOP patients show significant cognitive impairment that, during this early phase, seems to be non-specific to differential diagnosis.
authors.affiliation: Adolescent Unit, Department of Psychiatry, Hospital General Universitario Gregorio Marañón, c/Ibiza 43, 28009, Madrid, Spain. azabala@mce.hggm.es
authors.forename: Arantzazu
authors.initials: A
authors.lastname: Zabala
authors.forename: Marta
authors.initials: M
authors.lastname: Rapado
authors.forename: Celso
authors.initials: C
authors.lastname: Arango
authors.forename: Olalla
authors.initials: O
authors.lastname: Robles
authors.forename: Elena
authors.initials: E
authors.lastname: de la Serna
authors.forename: Cristina
authors.initials: C
authors.lastname: González
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Rodríguez-Sánchez
authors.forename: Patricia
authors.initials: P
authors.lastname: Andrés
authors.forename: María
authors.initials: M
authors.lastname: Mayoral
authors.forename: Igor
authors.initials: I
authors.lastname: Bombín
mesh_terms: D000293:Adolescent; D000704:Analysis of Variance; D001288:Attention / Q000502:physiology; D002648:Child; D003072:Cognition Disorders / Q000145:classification / Q000175:diagnosis* / Q000209:etiology*; D056344:Executive Function / Q000502:physiology; D006801:Humans; D008137:Longitudinal Studies; D008570:Memory, Short-Term / Q000502:physiology; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000150:complications* / Q000175:diagnosis* / Q000523:psychology; D012189:Retrospective Studies; D013030:Spain; D018709:Statistics, Nonparametric