Pure erythroid leukemia with hemophagocytosis.
A 53-year-old man was admitted with pancytopenia, fever and splenomegaly. Biochemistry showed increased ferritin levels. Bone marrow examination revealed increased erythrocytic precursors (94.9%) and active hemophagocytosis. Pure erythroid leukemia with hemophagocytic syndrome (HPS) was diagnosed. Induction chemotherapy comprising idarubicin and cytarabine was administered and steroid pulse therapy was added. Complete remission was attained, and HPS also improved. However, leukemia relapsed during chemotherapy and the patient died. This is the first report of pure erythroid leukemia complicated with HPS.
Kitagawa
Junichi
J
Department of Internal Medicine, Kisogawa Municipal Hospital, Ichinomiya, Japan.
Hara
Takeshi
T
Tsurumi
Hisashi
H
Oyama
Masami
M
Moriwaki
Hisataka
H
D000970:Antineoplastic Agents / Q000627:therapeutic use; D001853:Bone Marrow / Q000473:pathology; D003561:Cytarabine / Q000627:therapeutic use; D017809:Fatal Outcome; D006801:Humans; D015255:Idarubicin / Q000627:therapeutic use; D004915:Leukemia, Erythroblastic, Acute / Q000150:complications* / Q000188:drug therapy / Q000235:genetics / Q000473:pathology; D051359:Lymphohistiocytosis, Hemophagocytic / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged
D000970:Antineoplastic Agents; D003561:Cytarabine; D008775:Methylprednisolone; D015255:Idarubicin