title: Global analysis of extracytoplasmic stress signaling in Escherichia coli.
abstract: The Bae, Cpx, Psp, Rcs, and sigma(E) pathways constitute the Escherichia coli signaling systems that detect and respond to alterations of the bacterial envelope. Contributions of these systems to stress response have previously been examined individually; however, the possible interconnections between these pathways are unknown. Here we investigate the dynamics between the five stress response pathways by determining the specificities of each system with respect to signal-inducing conditions, and monitoring global transcriptional changes in response to transient overexpression of each of the effectors. Our studies show that different extracytoplasmic stress conditions elicit a combined response of these pathways. Involvement of the five pathways in the various tested stress conditions is explained by our unexpected finding that transcriptional responses induced by the individual systems show little overlap. The extracytoplasmic stress signaling pathways in E. coli thus regulate mainly complementary functions whose discrete contributions are integrated to mount the full adaptive response.
authors.affiliation: Laboratoire de Signalisation et Réseaux de Régulations Bactériens, Université Paris-Sud 11, CNRS, UMR8621, Institut de Génétique et Microbiologie Bâtiment 400, Orsay Cedex, France. stephanie.bury-mone@lbpa.ens-cachan.fr
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Bury-Moné
authors.forename: Yanoura
authors.initials: Y
authors.lastname: Nomane
authors.forename: Nancie
authors.initials: N
authors.lastname: Reymond
authors.forename: Romain
authors.initials: R
authors.lastname: Barbet
authors.forename: Eric
authors.initials: E
authors.lastname: Jacquet
authors.forename: Sandrine
authors.initials: S
authors.lastname: Imbeaud
authors.forename: Annick
authors.initials: A
authors.lastname: Jacq
authors.forename: Philippe
authors.initials: P
authors.lastname: Bouloc
mesh_terms: D003593:Cytoplasm / Q000235:genetics*; D004926:Escherichia coli / Q000235:genetics*; D020869:Gene Expression Profiling; D015964:Gene Expression Regulation, Bacterial; D005798:Genes, Bacterial; D018085:Regulon / Q000235:genetics; D015398:Signal Transduction / Q000235:genetics*; D013312:Stress, Physiological / Q000235:genetics*