title: Increased low density lipoprotein and increased likelihood of positive prostate biopsy in black americans.
abstract: OBJECTIVE
  Differences in prostate cancer incidence, grade and stage at diagnosis, and survival in black vs nonblack men are well documented. Recent studies indicate that lipids may have a role in oncogenesis, including that of prostate cancer. We investigated the relationship between circulating lipids in black and nonblack patients, and newly diagnosed prostate cancer.
  
  
  METHODS
  The study population included consecutive patients who underwent prostate biopsy for increased prostate specific antigen and/or abnormal digital rectal examination at Atlanta Veterans Affairs Medical Center. Age, race, prostate specific antigen, prostate volume, body mass index, family history, high and low density lipoprotein, triglyceride and cholesterol lowering medications were included in data analysis.
  
  
  RESULTS
  A total of 1,775 men with complete information were included in data analysis. A total of 521 black and 451 white men had positive biopsies. Using 100 mg/dl or less as the referent the adjusted OR reflecting the association of low density lipoprotein and prostate cancer diagnosis in black men was 1.49 (95% CI 1.04-2.13, p = 0.031), 1.51 (95% CI 0.96-2.39, p = 0.076) and 3.24 (95% CI 1.59-6.92, p = 0.002) for low density lipoprotein greater than 100 to 130, greater than 130 to 160 and greater than 160 mg/dl, respectively. Corresponding results in nonblack men showed no significant association.
  
  
  CONCLUSIONS
  Increased serum low density lipoprotein is associated with an increased likelihood of prostate cancer diagnosis in black men but not in nonblack men. This association is strongest in the highest low density lipoprotein risk category. The reasons for the racial differences are unknown but may include genetic, dietary or other environmental factors.
authors.affiliation: Department of Urology, Atlanta Veterans Affairs Medical Center, Emory University School of Medicine, Emory University, Atlanta, Georgia 30033, USA.
authors.forename: Kelvin A
authors.initials: KA
authors.lastname: Moses
authors.forename: Thura T
authors.initials: TT
authors.lastname: Abd
authors.forename: Michael
authors.initials: M
authors.lastname: Goodman
authors.forename: Wayland
authors.initials: W
authors.lastname: Hsiao
authors.forename: John A
authors.initials: JA
authors.lastname: Hall
authors.forename: Fray F
authors.initials: FF
authors.lastname: Marshall
authors.forename: John A
authors.initials: JA
authors.lastname: Petros
authors.forename: Muta M
authors.initials: MM
authors.lastname: Issa
mesh_terms: D000328:Adult; D001741:Black or African American; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy / Q000706:statistics & numerical data; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000097:blood* / Q000453:epidemiology / Q000473:pathology*
chemical_list: D008077:Lipoproteins, LDL