title: Nonclonal emergence of colistin-resistant Klebsiella pneumoniae isolates from blood samples in South Korea.
abstract: In vitro activities of colistin and other drugs were tested against 221 Klebsiella pneumoniae isolates that were collected between 2006 and 2007 in nine tertiary care South Korean hospitals from patients with bacteremia. The clonality of colistin-resistant K. pneumoniae (CRKP) isolates was assessed by multilocus sequence typing (MLST). We found that 15 isolates (6.8%) were resistant to colistin. MLST showed that CRKP isolates were nonclonal, with colistin resistance in K. pneumoniae occurring independently and not by clonal spreading.
authors.affiliation: Asian-Pacific Research Foundation for Infectious Diseases (ARFID), Seoul, South Korea.
authors.forename: Ji-Yoeun
authors.initials: JY
authors.lastname: Suh
authors.forename: Jun Seong
authors.initials: JS
authors.lastname: Son
authors.forename: Doo Ryeon
authors.initials: DR
authors.lastname: Chung
authors.forename: Kyong Ran
authors.initials: KR
authors.lastname: Peck
authors.forename: Kwan Soo
authors.initials: KS
authors.lastname: Ko
authors.forename: Jae-Hoon
authors.initials: JH
authors.lastname: Song
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D016470:Bacteremia / Q000382:microbiology; D003091:Colistin / Q000494:pharmacology*; D003428:Cross Infection / Q000382:microbiology; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D006801:Humans; D007710:Klebsiella Infections / Q000097:blood / Q000382:microbiology*; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000235:genetics*; D008826:Microbial Sensitivity Tests; D011159:Population Surveillance; D056910:Republic of Korea / Q000453:epidemiology
chemical_list: D000900:Anti-Bacterial Agents; D003091:Colistin