title: Health-e-Child project: mechanical dyssynchrony in children with dilated cardiomyopathy.
abstract: OBJECTIVE
  Left ventricular mechanical dyssynchrony has been poorly studied in the pediatric population with dilated cardiomyopathy. We investigated the degree of dyssynchrony in children with dilated cardiomyopathy using tissue Doppler imaging and speckle tracking strain.
  
  
  METHODS
  Twenty-five children with dilated cardiomyopathy were compared with healthy subjects. Left ventricular mechanical dyssynchrony was assessed by speckle tracking strain and tissue Doppler imaging. Both radial and longitudinal dyssynchrony were analyzed. Left ventricular end-diastolic diameter was measured to assess the relation between dyssynchrony and ventricular function and remodeling.
  
  
  RESULTS
  Radial and longitudinal dyssynchrony parameters were significantly higher in the dilated cardiomyopathy group and correlated with Z-score left ventricular end-diastolic diameter. A logarithmic correlation between left ventricular ejection fraction and left ventricular end-diastolic diameter parameters was found.
  
  
  CONCLUSIONS
  In children with dilated cardiomyopathy, tissue Doppler imaging and speckle tracking strain allowed the detection of dyssynchrony, which correlates with the severity of left ventricular function.
authors.affiliation: Hôpital Necker-Enfants Malades, Paris, France.
authors.forename: Fabien
authors.initials: F
authors.lastname: Labombarda
authors.forename: Julie
authors.initials: J
authors.lastname: Blanc
authors.forename: Arnaud
authors.initials: A
authors.lastname: Pellissier
authors.forename: Bertrand
authors.initials: B
authors.lastname: Stos
authors.forename: Cathy
authors.initials: C
authors.lastname: Gaillard
authors.forename: Fanny
authors.initials: F
authors.lastname: Bajolle
authors.forename: Alice
authors.initials: A
authors.lastname: Maltret
authors.forename: Daniel
authors.initials: D
authors.lastname: Sidi
authors.forename: Damien
authors.initials: D
authors.lastname: Bonnet
authors.forename: Younes
authors.initials: Y
authors.lastname: Boudjemline
mesh_terms: D002311:Cardiomyopathy, Dilated / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D016022:Case-Control Studies; D002648:Child; D015150:Echocardiography, Doppler; D004562:Electrocardiography; D005260:Female; D006329:Heart Conduction System / Q000503:physiopathology*; D006801:Humans; D008297:Male; D018709:Statistics, Nonparametric; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000503:physiopathology*