title: Incidental gallbladder carcinoma diagnosed during or after laparoscopic cholecystectomy.
abstract: BACKGROUND
  Gallbladder carcinoma (GC) is a highly lethal neoplasm. With the increase of cholecystectomies since the wide acceptance of laparoscopic cholecystectomy (LC), the incidental diagnosis of gallbladder carcinoma is more frequent. The aim of the present study was to report our experience with GC diagnosed during or after the performance of LC.
  
  
  METHODS
  A total of 10,466 LCs were carried out from January 1999 to December 2007 in our hospital. Records of patients with incidental carcinoma were collected and analyzed retrospectively.
  
  
  RESULTS
  Of all the patients, 20 (0.19%) were histopathologically diagnosed as having a GC. There were 4 men and 16 women; the median age in this group was 65.7 years (range: 37-81 years).The depth of cancer invasion was: pTis (4 cases), pT1a (2 cases), pT1b (2 cases), pT2 (6 cases), pT3 (4 cases), and pT4 (2 cases). The sensitivity and specificity of intraoperatively frozen section examination were 83.3 and 100%, respectively. Patients with in situ, pT1a and pT1b tumors underwent LC only, and there were no recurrences. The survival rate between patients with GC diagnosed during or after LC showed no difference; it was dependent on the depth of cancer invasion.
  
  
  CONCLUSIONS
  The survival with incidental GC is related to stage, and it validates that a carefully performed LC is adequate treatment for carcinoma in situ, and stage 1a and b cancer. A frozen section examination was helpful but did not provide a definitive diagnosis. Meticulous techniques during LC, including retrieval of the gallbladder in a retrieval bag, may prevent port-site recurrence and intraperitoneal dissemination.
authors.affiliation: Department of General Surgery, 101th Hospital of Chinese People's Liberation Army, North Xingyuan Road, 214044 Wuxi, Jiangsu, China. zhang_weijie@yahoo.cn
authors.forename: Wei-Jie
authors.initials: WJ
authors.lastname: Zhang
authors.forename: Gui-Fang
authors.initials: GF
authors.lastname: Xu
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Zou
authors.forename: Wei-Bing
authors.initials: WB
authors.lastname: Wang
authors.forename: Jun-Chi
authors.initials: JC
authors.lastname: Yu
authors.forename: Guo-Zhong
authors.initials: GZ
authors.lastname: Wu
authors.forename: Chun-Lei
authors.initials: CL
authors.lastname: Lu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017081:Cholecystectomy, Laparoscopic; D005260:Female; D005704:Gallbladder / Q000473:pathology* / Q000601:surgery*; D005706:Gallbladder Neoplasms / Q000175:diagnosis / Q000601:surgery*; D006801:Humans; D033162:Incidental Findings; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000601:surgery*; D011379:Prognosis; D012086:Reoperation; D012189:Retrospective Studies; D016019:Survival Analysis