Immune responses following one and two doses of the reformulated, bivalent, killed, whole-cell, oral cholera vaccine among adults and children in Kolkata, India: a randomized, placebo-controlled trial.
Immune responses after one and two doses of the reformulated killed oral cholera vaccine were measured in a double-blind, randomized, placebo-controlled trial of 77 adults aged 18-40 years and 77 children aged 1-17 years residing in Kolkata, India. 65% of adults and 87% of children and 46% of adults and 82% of children exhibited a > or =4-fold rise in serum Vibrio cholerae O1 vibriocidal antibody titers from baseline following dose 1 and 2, respectively. Responses to V. cholerae O139 were less pronounced but followed a similar pattern. We demonstrate that in a cholera-endemic area, the vaccine elicited vibriocidal responses after a single-dose of the vaccine.
Kanungo
Suman
S
National Institute of Cholera and Enteric Diseases, Kolkata, India.
Paisley
Allison
A
Lopez
Anna Lena
AL
Bhattacharya
Mihir
M
Manna
Byomkesh
B
Kim
Deok Ryun
DR
Han
Seung Hyun
SH
Attridge
Stephen
S
Carbis
Rodney
R
Rao
Raman
R
Holmgren
Jan
J
Clemens
John D
JD
Sur
Dipika
D
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood*; D000917:Antibody Formation; D002648:Child; D002675:Child, Preschool; D002771:Cholera / Q000276:immunology / Q000517:prevention & control*; D022121:Cholera Vaccines / Q000276:immunology*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007117:Immunization, Secondary; D007194:India; D007223:Infant; D008297:Male; D015164:Vaccines, Inactivated / Q000276:immunology; D055815:Young Adult
D000907:Antibodies, Bacterial; D022121:Cholera Vaccines; D015164:Vaccines, Inactivated