[Reduced bone density and bone pain :osteomalacia with hypophospatemia and hypophosphaturia].
Two patients aged 24 and 64 years presented at our hospital with similar symptoms including bone pain and muscle weakness. Basic laboratory tests and urinary diagnostics, bone densitometry and bone histology revealed severe osteomalacia with renal phosphate wasting. After the exclusion of other causes an extensive tumor search was performed due to suspected tumor-induced osteomalacia. In one patient a mesenchymal tumor was found in the thigh and completely resected. After surgery the patient showed a rapid recovery from osteomalacia. Because the search was unsuccessful in the other patient phosphorus supplementation in combination with calcitriol was started. Despite continuing renal phosphate wasting a significant increase in bone mineral density was observed.
Findeisen
H M
HM
Medizinische Klinik II Grosshadern, Klinikum der LMU München, Marchioninistrasse 15, 81377, München, Deutschland.
Auernhammer
C J
CJ
Parhofer
K G
KG
Herrmann
K A
KA
la Fougere
C
C
Weiler
C
C
Bartl
R
R
Koch
E
E
D018771:Arthralgia / Q000175:diagnosis* / Q000209:etiology*; D006801:Humans; D017674:Hypophosphatemia / Q000175:diagnosis* / Q000209:etiology*; D008875:Middle Aged; D010018:Osteomalacia / Q000175:diagnosis* / Q000209:etiology*; D012983:Soft Tissue Neoplasms / Q000150:complications* / Q000175:diagnosis; D055815:Young Adult