title: An intervention integrated into daily clinical practice reduces the incidence of delirium during hospitalization in elderly patients.
abstract: OBJECTIVE
  To analyze the effectiveness of a multicomponent intervention integrated into daily practice for the prevention of in-hospital delirium in elderly patients.
  
  
  METHODS
  Controlled study comparing an intervention in a geriatric unit (GI) with usual care in two internal medicine services (UC).
  
  
  METHODS
  University hospital in Madrid, Spain.
  
  
  METHODS
  Five hundred forty-two consecutive patients (170 GI, 372 UC), aged 70 and older, with any of the risk criteria for delirium (cognitive impairment, visual impairment, acute disease severity, dehydration).
  
  
  METHODS
  Educational measures and specific actions in seven risk areas (orientation, sensory impairment, sleep, mobilization, hydration, nutrition, drug use). Daily monitoring of adherence.
  
  
  METHODS
  Baseline characteristics, risk factors for delirium, and quality care indicators were analyzed. The primary endpoint was incidence of delirium assessed daily. The secondary endpoint was functional decline, defined as loss of independence in any of the activities of daily living. The intervention effect was evaluated using logistic regression analysis.
  
  
  RESULTS
  Delirium affected 11.7% of the GI group and 18.5% of the UC group (P=.04). After adjustment for confounders, the intervention was associated with lower incidence of delirium (odds ratio=0.4, 95% confidence interval=0.24-0.77; P=.005). In the patients who experienced delirium, severity, length, and recurrence of episodes were similar in both groups. Adherence to the intervention protocols was 75.7%. The intervention reduced the rate of functional decline (45.5% in GI vs 56.3% in UC, P=.03) and improved other quality indicators (e.g., mobilization and physical restraints reduction).
  
  
  CONCLUSIONS
  A multicomponent, nonpharmacological intervention integrated into routine practice reduces delirium during hospitalization in older patients, improves quality of care, and can be implemented without additional resources in a public healthcare system.
authors.affiliation: Department of Geriatric Medicine, Hospital General Universitario Gregorio Marañón, Madrid, Spain. mvidan.hgugm@salud.madrid.org
authors.forename: María T
authors.initials: MT
authors.lastname: Vidán
authors.forename: Elisabet
authors.initials: E
authors.lastname: Sánchez
authors.forename: Mar
authors.initials: M
authors.lastname: Alonso
authors.forename: Beatriz
authors.initials: B
authors.lastname: Montero
authors.forename: Javier
authors.initials: J
authors.lastname: Ortiz
authors.forename: José A
authors.initials: JA
authors.lastname: Serra
mesh_terms: D018806:APACHE; D000203:Activities of Daily Living / Q000145:classification; D000368:Aged; D000369:Aged, 80 and over; D003131:Combined Modality Therapy; D003299:Cooperative Behavior; D003430:Cross-Sectional Studies; D003693:Delirium / Q000453:epidemiology / Q000451:nursing / Q000517:prevention & control* / Q000523:psychology; D005260:Female; D006760:Hospitalization; D006801:Humans; D015994:Incidence; D007318:Inservice Training; D033183:Interdisciplinary Communication; D008297:Male; D008609:Mental Status Schedule; D010348:Patient Care Team; D012307:Risk Factors; D013030:Spain