Modification of mortality and tumorigenesis by tocopherol-mono-glucoside (TMG) administered after X irradiation in mice and rats.
The effects of TMG [2-(alpha-d-glucopyranosyl) methyl-2,5,7,8-tetramethylchroman-6-ol], a water-soluble vitamin E derivative, administered after irradiation on the mortality of X-irradiated mice and on the development of tumors in the mammary and pituitary glands in rats were investigated. When TMG (650 mg/kg) was administered intraperitoneally (i.p.) to C3H mice immediately after whole-body exposure to 7 Gy radiation, the 30-day survival was significantly higher than that of the control mice. The i.p. administration of TMG at 4 h after irradiation significantly improved survival compared to that of the controls, but administration 8 h after irradiation did not have a significant effect. Subcutaneous administration of TMG immediately after irradiation also decreased mortality significantly. When dams of lactating Wister rats were exposed to 1.5 Gy of X rays at day 21 after parturition and were then treated with diethylstilbestrol as a tumor promoter, the incidence of mammary tumors and pituitary tumors was increased compared to that in the nonirradiated control group. The administration of TMG (600 mg/kg, i.p.) after irradiation significantly reduced the incidence of mammary tumors and pituitary tumors. The number of rats that were free of both mammary and pituitary gland tumors was enhanced fourfold by TMG. These results suggest that TMG is effective in preventing radiation-induced bone marrow death in mice and in reducing mammary and pituitary tumors in rats even when it is administered after irradiation.
Ueno
Megumi
M
Heavy-Ion Radiobiology Research Group, National Institute of Radiological Sciences, Inage-ku, Chiba, Japan.
Inano
Hiroshi
H
Onoda
Makoto
M
Murase
Hironobu
H
Ikota
Nobuo
N
Kagiya
Tsutomu V
TV
Anzai
Kazunori
K
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000528:radiation effects; D001943:Breast Neoplasms / Q000473:pathology / Q000517:prevention & control; D016166:Free Radical Scavengers / Q000008:administration & dosage* / Q000494:pharmacology*; D005960:Glucosides / Q000008:administration & dosage* / Q000494:pharmacology*; D051379:Mice; D009026:Mortality; D009381:Neoplasms, Radiation-Induced / Q000473:pathology* / Q000517:prevention & control*; D010911:Pituitary Neoplasms / Q000473:pathology / Q000517:prevention & control; D051381:Rats; D013997:Time Factors; D024505:Tocopherols / Q000008:administration & dosage / Q000494:pharmacology; D014965:X-Rays / Q000009:adverse effects
D016166:Free Radical Scavengers; D005960:Glucosides; C460320:tocopherol monoglucoside; D024505:Tocopherols