High safety profile and activity of oral vinorelbine in an elderly patient with metastatic breast cancer.
Visceral metastases of breast cancer have been commonly treated with "aggressive" anthracyclines/taxanes-based chemotherapy. In contrast, this case report concerns an elderly patient with advanced breast cancer (pleural effusion, peritoneal carcinosis, and bone metastases) who firmly declined intravenous chemotherapy and was treated for a long time (28 months) with oral vinorelbine. The oral formulation of this drug had activity and a high safety profile, enabling the patient's wishes to be respected.
Rossi
David
D
Operative Oncology Unit, S. Salvatore Hospital, Pesaro, Italy. d.rossi63@libero.it
Baldelli
Anna Maria
AM
Catalano
Vincenzo
V
Casadei
Virginia
V
Alessandroni
Paolo
P
Giordani
Paolo
P
Graziano
Francesco
F
Fedeli
Stefano Luzi
SL
D000284:Administration, Oral; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000188:drug therapy / Q000556:secondary; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010996:Pleural Effusion / Q000175:diagnosis / Q000209:etiology; D013997:Time Factors; D014747:Vinblastine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000077235:Vinorelbine
D000972:Antineoplastic Agents, Phytogenic; D014747:Vinblastine; D000077235:Vinorelbine