Codon usage and gene expression pattern of Stenotrophomonas maltophilia R551-3 for pathogenic mode of living.
Stenotrophomonas maltophilia strain R551-3 is a multiple-antibiotic-resistant opportunistic human pathogen involved in nosocomial infections. It has a widely distributed GC-rich (>66%) genome. Analysis of differential expression of the genes of this genome reveals that majority of genes belonging to highly expressed category are mostly present on lagging strand without showing any strand specific codon usage bias. Relatively small number of lowly expressed genes is equally distributed on both leading and lagging strands with a difference in codon usage pattern between them. Among several multi drug resistance genes of S. maltophilia involving lowly expressed category some are predicted as horizontally transferred. It can be inferred that horizontally transferred genes may have been imported into this genome for their pathogenic mode of living. Our study may help to modify the expression level of the target genes of this human pathogen in order to control its infection.
Banerjee
Rachana
R
Bioinformatics Centre, Bose Institute, Kolkata 700054, India.
Roy
Debjani
D
D003062:Codon / Q000235:genetics*; D020869:Gene Expression Profiling; D015964:Gene Expression Regulation, Bacterial; D006801:Humans; D020615:Stenotrophomonas maltophilia / Q000235:genetics* / Q000472:pathogenicity*
D003062:Codon