In vivo selection of carbapenem-resistant Klebsiella pneumoniae by OmpK36 loss during meropenem treatment.
We recovered a carbapenem-resistant Klebsiella pneumoniae isolate H224 under in vivo meropenem selection pressure. Insertional inactivation of a major porin gene, ompK36, by IS5 element might play a role in acquiring carbapenem resistance in this strain harboring plasmid-borne DHA-1 AmpC beta-lactamase.
Song
Wonkeun
W
Department of Laboratory Medicine, Hallym University College of Medicine, 120-950 Seoul, Republic of Korea.
Suh
Borum
B
Choi
Jun Yong
JY
Jeong
Seok Hoon
SH
Jeon
Eun Hee
EH
Lee
Young Ki
YK
Hong
Seong Geun
SG
Lee
Kyungwon
K
D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001426:Bacterial Proteins / Q000235:genetics*; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D005260:Female; D017353:Gene Deletion; D006801:Humans; D007710:Klebsiella Infections / Q000188:drug therapy* / Q000382:microbiology; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D000077731:Meropenem; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D010957:Plasmids; D018272:Porins / Q000235:genetics*; D012641:Selection, Genetic; D017422:Sequence Analysis, DNA; D013845:Thienamycins / Q000627:therapeutic use*; D018440:beta-Lactam Resistance
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D004269:DNA, Bacterial; C092233:OmpK36 protein, Klebsiella pneumoniae; D018272:Porins; D013845:Thienamycins; D000077731:Meropenem