[Extranuclear functions of protein sumoylation in the central nervous system].
Post-translational protein modifications play essential roles in many aspects of cellular functions and therefore in the maintenance of cell integrity. These protein modifications are involved at all stages of neuronal communication within the central nervous system. Sumoylation is a reversible post-translational protein modification that consists in the covalent labelling of a small protein called SUMO to lysine residues of selected target proteins. Sumoylation is a well characterized regulator of nuclear functions and has recently emerged as a key factor for numerous extranuclear processes. Furthermore, sumoylation has recently been shown to modulate synaptic transmission and is also implicated in a wide range of neurodegenerative diseases.
Martin
Stéphane
S
Institut de neuromédecine moléculaire, Institut de pharmacologie moléculaire et cellulaire, Centre national de la recherche scientifique, UMR 6097, Université de Nice Sophia-Antipolis, 660, route des Lucioles, Sophia-Antipolis, 06560 Valbonne, France. smartin@in2m.cnrs.fr
D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D016923:Cell Death; D002467:Cell Nucleus / Q000502:physiology; D002490:Central Nervous System / Q000378:metabolism*; D019204:GTP-Binding Proteins / Q000502:physiology; D006801:Humans; D008239:Lysine / Q000378:metabolism; D008928:Mitochondria / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D010300:Parkinson Disease / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D011499:Protein Processing, Post-Translational; D013569:Synapses / Q000502:physiology; D025801:Ubiquitin / Q000378:metabolism
D009419:Nerve Tissue Proteins; D025801:Ubiquitin; D019204:GTP-Binding Proteins; D008239:Lysine