title: Real-time studies of conformational dynamics of the repair enzyme E. coli formamidopyrimidine-DNA glycosylase and its DNA complexes during catalytic cycle.
abstract: Fpg protein from Escherichia coli belongs to the class of DNA glycosylases/abasic site lyases excising several oxidatively damaged purines in the base excision repair pathway. In this review, we summarize the results of our studies of Fpg protein from E. coli, elucidating the intrinsic mechanism of recognition and excision of damaged bases in DNA.
authors.affiliation: Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Lavrentyev Ave. 8, Novosibirsk 630090, Russia.
authors.forename: Vladimir V
authors.initials: VV
authors.lastname: Koval
authors.forename: Nikita A
authors.initials: NA
authors.lastname: Kuznetsov
authors.forename: Alexander A
authors.initials: AA
authors.lastname: Ishchenko
authors.forename: Murat K
authors.initials: MK
authors.lastname: Saparbaev
authors.forename: Olga S
authors.initials: OS
authors.lastname: Fedorova
mesh_terms: D002384:Catalysis; D004247:DNA; D043382:DNA-Formamidopyrimidine Glycosylase / Q000737:chemistry*; D029968:Escherichia coli Proteins / Q000737:chemistry*; D007700:Kinetics; D008968:Molecular Conformation; D009154:Mutation
chemical_list: D029968:Escherichia coli Proteins; D004247:DNA; D043382:DNA-Formamidopyrimidine Glycosylase