title: Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility.
abstract: We report a prostate cancer genome-wide association follow-on study. We discovered four variants associated with susceptibility to prostate cancer in several European populations: rs10934853[A] (OR = 1.12, P = 2.9 x 10(-10)) on 3q21.3; two moderately correlated (r2 = 0.07) variants, rs16902094[G] (OR = 1.21, P = 6.2 x 10(-15)) and rs445114[T] (OR = 1.14, P = 4.7 x 10(-10)), on 8q24.21; and rs8102476[C] (OR = 1.12, P = 1.6 x 10(-11)) on 19q13.2. We also refined a previous association signal on 11q13 with the SNP rs11228565[A] (OR = 1.23, P = 6.7 x 10(-12)). In a multivariate analysis using 22 prostate cancer risk variants typed in the Icelandic population, we estimated that carriers in the top 1.3% of the risk distribution are at a 2.5 times greater risk of developing the disease than members of the general population.
authors.affiliation: deCODE Genetics, Reykjavik, Iceland.
authors.forename: Julius
authors.initials: J
authors.lastname: Gudmundsson
authors.forename: Patrick
authors.initials: P
authors.lastname: Sulem
authors.forename: Daniel F
authors.initials: DF
authors.lastname: Gudbjartsson
authors.forename: Thorarinn
authors.initials: T
authors.lastname: Blondal
authors.forename: Arnaldur
authors.initials: A
authors.lastname: Gylfason
authors.forename: Bjarni A
authors.initials: BA
authors.lastname: Agnarsson
authors.forename: Kristrun R
authors.initials: KR
authors.lastname: Benediktsdottir
authors.forename: Droplaug N
authors.initials: DN
authors.lastname: Magnusdottir
authors.forename: Gudbjorg
authors.initials: G
authors.lastname: Orlygsdottir
authors.forename: Margret
authors.initials: M
authors.lastname: Jakobsdottir
authors.forename: Simon N
authors.initials: SN
authors.lastname: Stacey
authors.forename: Asgeir
authors.initials: A
authors.lastname: Sigurdsson
authors.forename: Tiina
authors.initials: T
authors.lastname: Wahlfors
authors.forename: Teuvo
authors.initials: T
authors.lastname: Tammela
authors.forename: Joan P
authors.initials: JP
authors.lastname: Breyer
authors.forename: Kate M
authors.initials: KM
authors.lastname: McReynolds
authors.forename: Kevin M
authors.initials: KM
authors.lastname: Bradley
authors.forename: Berta
authors.initials: B
authors.lastname: Saez
authors.forename: Javier
authors.initials: J
authors.lastname: Godino
authors.forename: Sebastian
authors.initials: S
authors.lastname: Navarrete
authors.forename: Fernando
authors.initials: F
authors.lastname: Fuertes
authors.forename: Laura
authors.initials: L
authors.lastname: Murillo
authors.forename: Eduardo
authors.initials: E
authors.lastname: Polo
authors.forename: Katja K
authors.initials: KK
authors.lastname: Aben
authors.forename: Inge M
authors.initials: IM
authors.lastname: van Oort
authors.forename: Brian K
authors.initials: BK
authors.lastname: Suarez
authors.forename: Brian T
authors.initials: BT
authors.lastname: Helfand
authors.forename: Donghui
authors.initials: D
authors.lastname: Kan
authors.forename: Carlo
authors.initials: C
authors.lastname: Zanon
authors.forename: Michael L
authors.initials: ML
authors.lastname: Frigge
authors.forename: Kristleifur
authors.initials: K
authors.lastname: Kristjansson
authors.forename: Jeffrey R
authors.initials: JR
authors.lastname: Gulcher
authors.forename: Gudmundur V
authors.initials: GV
authors.lastname: Einarsson
authors.forename: Eirikur
authors.initials: E
authors.lastname: Jonsson
authors.forename: William J
authors.initials: WJ
authors.lastname: Catalona
authors.forename: Jose I
authors.initials: JI
authors.lastname: Mayordomo
authors.forename: Lambertus A
authors.initials: LA
authors.lastname: Kiemeney
authors.forename: Jeffrey R
authors.initials: JR
authors.lastname: Smith
authors.forename: Johanna
authors.initials: J
authors.lastname: Schleutker
authors.forename: Rosa B
authors.initials: RB
authors.lastname: Barkardottir
authors.forename: Augustine
authors.initials: A
authors.lastname: Kong
authors.forename: Unnur
authors.initials: U
authors.lastname: Thorsteinsdottir
authors.forename: Thorunn
authors.initials: T
authors.lastname: Rafnar
authors.forename: Kari
authors.initials: K
authors.lastname: Stefansson
mesh_terms: D004247:DNA / Q000235:genetics*; D004261:DNA Replication; D004198:Disease Susceptibility; D015894:Genome, Human; D055106:Genome-Wide Association Study; D006801:Humans; D007055:Iceland; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms / Q000453:epidemiology / Q000235:genetics*; D012307:Risk Factors; D044465:White People / Q000235:genetics
chemical_list: D004247:DNA