title: Japonicones E-L, dimeric sesquiterpene lactones from Inula japonica Thunb.
abstract: Eight new dimeric sesquiterpene lactones (japonicones E-L, 1- 8), including a novel sesquiterpene dimer bearing a rare hydroperoxide group (japonicone E, 1), were isolated from the aerial part of Inula japonica Thunb. Their structures were determined mainly by the use of 1D and 2D NMR spectroscopic techniques including HSQC, (1)H-(1)H COSY, HMBC, and NOESY. All the isolates were tested for inhibitory effects against LPS-induced NO production in RAW264.7 macrophages. Among the compounds tested, japonicone F (2) showed the strongest activity with the IC(50) value of 4.1 microg/mL.
authors.affiliation: School of Pharmacy, Shanghai Jiao Tong University, Shanghai, PR China.
authors.forename: Jiang Jiang
authors.initials: JJ
authors.lastname: Qin
authors.forename: Hui Zi
authors.initials: HZ
authors.lastname: Jin
authors.forename: Jia Xian
authors.initials: JX
authors.lastname: Zhu
authors.forename: Jian Jun
authors.initials: JJ
authors.lastname: Fu
authors.forename: Xiao Jia
authors.initials: XJ
authors.lastname: Hu
authors.forename: Xiao Hua
authors.initials: XH
authors.lastname: Liu
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhu
authors.forename: Shi Kai
authors.initials: SK
authors.lastname: Yan
authors.forename: Wei Dong
authors.initials: WD
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006861:Hydrogen Peroxide; D020128:Inhibitory Concentration 50; D038143:Inula / Q000737:chemistry*; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008070:Lipopolysaccharides; D008264:Macrophages / Q000187:drug effects*; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000096:biosynthesis*; D035261:Plant Components, Aerial; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000893:Anti-Inflammatory Agents; D007783:Lactones; D008070:Lipopolysaccharides; D012717:Sesquiterpenes; C549908:japonicone E; C549909:japonicone L; D009569:Nitric Oxide; D006861:Hydrogen Peroxide