Discontinuation of hormone therapy in the French GAZEL cohort 1990-2006.
OBJECTIVE
To analyze changes in hormone therapy (HT) use after the publication of the Women's Health Initiative (WHI) results, in a country (France) where HT is different from that assessed in the WHI.


METHODS
Longitudinal study.


METHODS
Women in the GAZEL cohort of employees of the French national power company.


METHODS
One thousand six hundred five postmenopausal women ever-users of HT.


METHODS
None.


METHODS
Discontinuation of HT.


RESULTS
Rates of discontinuation were higher after 2002: 65% of users who began HT in 1998 were still using it after 5 years. In contrast, >90% of those who began before 1994 were still using it after 5 years. Discontinuation was associated with women's social and medical characteristics and with factors related to side effects and expectations concerning HT. After adjustment for these factors, women were twice as likely to stop HT after publication of the WHI.


CONCLUSIONS
Even in France, publication of the WHI has led to a decline in HT use.
Ringa
Virginie
V
Institut National d'Etudes Démographiques (INED), Le Kremlin-Bicêtre, France; Institut National de la Santé et de la Recherche Médicale (INSERM), Le Kremlin-Bicêtre, France; University Paris-Sud 11, Faculté de médecine Paris-Sud, Bicêtre Hospital, Le Kremlin-Bicêtre, France. Electronic address: virginie.ringa@inserm.fr.
Fritel
Xavier
X
INSERM, U953, IFR69, Villejuif, France; University Pierre-et-Marie-Curie Paris 6, Paris, France.
Varnoux
Noëlle
N
Institut National d'Etudes Démographiques (INED), Le Kremlin-Bicêtre, France; Institut National de la Santé et de la Recherche Médicale (INSERM), Le Kremlin-Bicêtre, France; University Paris-Sud 11, Faculté de médecine Paris-Sud, Bicêtre Hospital, Le Kremlin-Bicêtre, France.
Zins
Marie
M
INSERM, U687, Saint-Maurice, France; Equipe Risques Post-Professionnels-Cohortes (RPPC) du Centre technique d'appui et de formation des centres d'examens de santé (CETAF), Saint-Maurice and Institut Fédératif de Recherche (IFR69), Villejuif, France.
Quelen
Céline
C
Institut National d'Etudes Démographiques (INED), Le Kremlin-Bicêtre, France; Institut National de la Santé et de la Recherche Médicale (INSERM), Le Kremlin-Bicêtre, France; University Paris-Sud 11, Faculté de médecine Paris-Sud, Bicêtre Hospital, Le Kremlin-Bicêtre, France.
Bouyer
Jean
J
Institut National d'Etudes Démographiques (INED), Le Kremlin-Bicêtre, France; Institut National de la Santé et de la Recherche Médicale (INSERM), Le Kremlin-Bicêtre, France; University Paris-Sud 11, Faculté de médecine Paris-Sud, Bicêtre Hospital, Le Kremlin-Bicêtre, France.
D000328:Adult; D015331:Cohort Studies; D015914:Estrogen Replacement Therapy / Q000009:adverse effects / Q000706:statistics & numerical data*; D005260:Female; D005602:France; D006801:Humans; D008137:Longitudinal Studies; D008593:Menopause / Q000187:drug effects; D008875:Middle Aged; D010349:Patient Compliance / Q000706:statistics & numerical data; D010353:Patient Education as Topic; D011210:Power Plants; D011795:Surveys and Questionnaires; D028761:Withholding Treatment / Q000706:statistics & numerical data*; D016387:Women's Health