title: Serum concentrations of the derivatives of reactive oxygen metabolites (d-ROMs) in dogs with leishmaniosis.
abstract: Leishmania infantum interferes with the oxidative metabolism of phagocytes. In order to assess whether derivatives of reactive oxygen metabolites (d-ROMs) decrease due to infection or increase due to inflammation, d-ROMs were measured in serum collected from control dogs (Group 1; n = 12), from dogs seropositive for Leishmania either symptomatic (Group 2; n = 27) or not (Group 3; n = 14), and from dogs with other diseases (Group 4; n = 16). The concentrations of d-ROMs in the four groups, expressed in Carratelli Units (U CARR) were, respectively, 75.4 ± 39.5 (median, 81.6), 108.2 ± 96.3 (73.4), 73.5 ± 62.2 (62.0), 127.7 ± 97.3 (94.3). There were no significant differences between groups, but dogs with values higher than the reference interval were found, mostly in Groups 2 and 4 (which had serum C-reactive protein levels consistent with inflammation), whilst low values were occasionally found in Groups 2 and 3. Inflammation may mask decreases in d-ROMs induced by Leishmania infection.
authors.affiliation: Department of Veterinary Pathology, Hygiene and Public Health, University of Milan, Italy. saverio.paltrinieri@unimi.it
authors.forename: Saverio
authors.initials: S
authors.lastname: Paltrinieri
authors.forename: Sara
authors.initials: S
authors.lastname: Ravicini
authors.forename: Gabriele
authors.initials: G
authors.lastname: Rossi
authors.forename: Xavier
authors.initials: X
authors.lastname: Roura
mesh_terms: D000818:Animals; D016022:Case-Control Studies; D004283:Dog Diseases / Q000097:blood*; D004285:Dogs; D005260:Female; D018314:Leishmania infantum; D007898:Leishmaniasis, Visceral / Q000097:blood / Q000662:veterinary*; D008297:Male; D017382:Reactive Oxygen Species / Q000097:blood*
chemical_list: D017382:Reactive Oxygen Species