Synthesis, characterization and DNA-binding studies of ruthenium(II) mixed-ligand complexes containing dipyrido[1,2,5]oxadiazolo[3,4-b]quinoxaline.
A novel ligand dipyrido[1,2,5]oxadiazolo[3,4-b]quinoxaline (dpoq) and its complexes [Ru(bpy)(2)(dpoq)](2+) and [Ru(phen)(2)(dpoq)](2+) (bpy=2,2'-bipyridine; phen=1,10-phenanthroline) have been synthesized and characterized by elemental analysis, electrospray mass spectra and (1)H NMR. The interaction of Ru(II) complexes with calf thymus DNA (CT-DNA) was investigated by absorption spectroscopy, fluorescence spectroscopy, thermal denaturation and viscosity measurements. Results suggest that two Ru(II) complexes bind to DNA via an intercalative mode.
Peng
Bin
B
MOE Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, PR China.
Chen
Xiang
X
Du
Ke-Jie
KJ
Yu
Bo-Le
BL
Chao
Hui
H
Ji
Liang-Nian
LN
D001667:Binding, Competitive; D004247:DNA / Q000737:chemistry*; D008024:Ligands; D009691:Nucleic Acid Denaturation; D011725:Pyridines / Q000138:chemical synthesis / Q000737:chemistry*; D011810:Quinoxalines / Q000138:chemical synthesis / Q000737:chemistry*; D017975:Ruthenium Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D017186:Titrimetry; D014783:Viscosity
D008024:Ligands; D011725:Pyridines; D011810:Quinoxalines; D017975:Ruthenium Compounds; D004247:DNA; C023666:pyridine