[Maintenance effect of polyglycosides of Tripterygium wilfordii on remission in postoperative Crohn disease].
OBJECTIVE
To observe the maintenance effect of polyglycosides of Tripterygium wilfordii (GTW) on remission in postoperative Crohn disease (CD).


METHODS
From 2005 to 2007, 45 adult cases of postoperative Crohn disease were randomly divided into two groups, GTW group and mesalazine group, which received GTW and mesalazine treatment respectively. CD activity index (CDAI) and clinical markers were collected at 0, 3, 6, 12 months or at the onset of symptoms. Ileocolonoscopy was performed at the end of the trial (1 year after operation) or at the onset of symptoms, and recurrence score were recorded.


RESULTS
No clinical recurrence was ascertained in both groups at 3 months. Four patients (18.2%) in GTW group relapsed and 5 (21.7%) in mesalazine group relapsed at 6 months (P=0.530). Seven patients (31.8%) in GTW group and 9 (39.1%) in mesalazine group relapsed at one year (P=0.421). Ten patients (45.5%) in GTW group had endoscopic recurrence compared with 14 (60.9%) in mesalazine group at one year(P=0.231). There were no significant differences between two groups.


CONCLUSIONS
GTW is similar to mesalazine in maintenance of remission of postoperative Crohn disease.
Tao
Qing-song
QS
Department of General Surgery, Zhongda Hospital, Southeast University, Nanjing, China.
Ren
Jian-an
JA
Ji
Zhen-ling
ZL
Li
Jun-sheng
JS
Wang
Xin-bo
XB
Jiang
Xiao-hua
XH
D000293:Adolescent; D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D003424:Crohn Disease / Q000188:drug therapy*; D006027:Glycosides / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D019804:Mesalamine / Q000627:therapeutic use; D008875:Middle Aged; D008517:Phytotherapy; D011184:Postoperative Period; D012008:Recurrence; D016896:Treatment Outcome; D029757:Tripterygium / Q000737:chemistry*; D055815:Young Adult
D000894:Anti-Inflammatory Agents, Non-Steroidal; D006027:Glycosides; D019804:Mesalamine