[Preparation and characterization of solid dispersions of ginkgolides].
OBJECTIVE
To optimize the preparation process of solid dispersions of ginkgolides to improve the drug dissolution.


METHODS
The influence of formulation and preparation technology on drug release from solid dispersions was investigated by single factor test. The X-ray diffraction analysis (XRD) and differential scanning calorimetry (DSC) were used to characterize the solid dispersions of ginkgolides.


RESULTS
The solubilization efficiency of solid dispersions using PVP k30 as carrier was better than that taking poloxamer 188 or HPMC as matrix. The results of XRD and DSC showed that ginkgolides existed in solid dispersion at amorphous form or solvates form. The dissolution rate of ginkgolide B in solid dispersion was increased dramatically compared with raw material.


CONCLUSIONS
Solid dispersions could significantly improve solubility and dissolution rate of ginkgolides.
Ma
Linyi
L
Department of Pharmaceutics, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
Han
Limei
L
Zhang
Zhirong
Z
Wang
Jianxin
J
D002152:Calorimetry, Differential Scanning; D046934:Ginkgolides / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D012995:Solubility; D014961:X-Ray Diffraction
D046934:Ginkgolides; D004364:Pharmaceutical Preparations