title: Chemical avulsion with urea nail lacquer.
abstract: BACKGROUND
  Among the therapeutic possibilities for onychomycosis, chemicalnail avulsion is a logical approach to the eradication of the pathogen.
  
  
  METHODS
  A new formulation was used as a nail lacquer containing 40% urea in a film-forming solution in 10 patients presenting with onychomycosis. The urea nail lacquer was applied with a brush twice a day for 1 week by the patient and for a further week in two patients presenting total dystrophic onychomycosis.
  
  
  RESULTS
  This transungual delivery system weakens the nail plate/nail bed attachment in the diseased area.
  
  
  CONCLUSIONS
  The urea nail lacquer is comfortable for the patient and allows easy removal of the affected part of the fungal nail plate.
authors.affiliation: Nail Disease Center, Cannes, France. baran.r@club-internet.fr
authors.forename: R
authors.initials: R
authors.lastname: Baran
authors.forename: A
authors.initials: A
authors.lastname: Tosti
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D000368:Aged; D000935:Antifungal Agents / Q000008:administration & dosage*; D015331:Cohort Studies; D005260:Female; D005533:Foot Dermatoses / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage*; D007764:Lacquer; D008297:Male; D008875:Middle Aged; D014009:Onychomycosis / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D014508:Urea / Q000008:administration & dosage*; D055815:Young Adult
chemical_list: D000935:Antifungal Agents; D007093:Imidazoles; D014508:Urea; C036596:bifonazole