[Changes of insulin resistance and islet beta cells function in subjects with high-normal blood pressure].
OBJECTIVE
To investigate the changes of insulin resistance and islet beta cells function in subjects with euglycemia and high-normal blood pressure.


METHODS
Total 423 subjects were divided into normal blood pressure group and high-normal blood pressure group. Body height, weight, waist and hip circumference, and biochemical data were measured. Homeostasis model assessment of insulin resistance (HOMA-IR), insulin sensitivity index (ISI)-composite, and first-phase (1 PH) Stumvoll index were calculated. Results Waist circumference, total cholesterol, triglyceride, low-density lipoprotein cholesterol, HOMA-IR were significantly higher and IPH Stumvoll index and ISI-composite were significantly lower in high-normal blood pressure group than in normal blood pressure group (P < 0.05). Systolic blood pressure (SBP) was positively correlated with HOMA-IR (r = 0.122) and negatively correlated with 1PH Stumvoll index (r = -0. 159) and ISI-composite (r = -0.131) (P < 0.05). SBP and triglyceride were independent factors for IPH Stumvoll index.


CONCLUSIONS
Insulin resistance and islet dysfunction may exist in subjects with high-normal blood pressure.
Xu
Ling-Ling
LL
Department of Endocrinology, Key Laboratory of Endocrinology Ministry of Health, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
Xiang
Hong-Ding
HD
Zhang
Li-Hong
LH
Chen
Wei
W
Fang
Jing-Hui
JH
D001794:Blood Pressure; D015992:Body Mass Index; D001835:Body Weight; D002784:Cholesterol / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D007333:Insulin Resistance / Q000502:physiology*; D014280:Triglycerides / Q000097:blood; D055105:Waist Circumference
D008078:Cholesterol, LDL; D014280:Triglycerides; D002784:Cholesterol