Mechanisms of chromosomal rearrangements in solid tumors: the model of papillary thyroid carcinoma.
Thyroid cancer, and its most common type, papillary carcinoma, frequently have chromosomal rearrangements and therefore represent a good model for the understanding of mechanisms of chromosomal rearrangements in solid tumors. Several types of rearrangement known to occur in thyroid cancer, including RET/PTC, NTRK1 and BRAF/AKAP9, are more common in radiation-associated thyroid tumors and RET/PTC can be induced experimentally by exposing human thyroid cells to ionizing radiation. In this review, the molecular mechanisms of generation of RET/PTC and other chromosomal rearrangements are discussed, with the emphasis on the role of nuclear architecture and interphase gene proximity in the generation of intrachromosomal rearrangements in thyroid cells.
Gandhi
Manoj
M
Department of Pathology and Laboratory Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Evdokimova
Viktoria
V
Nikiforov
Yuri E
YE
D001483:Base Sequence; D002291:Carcinoma, Papillary / Q000235:genetics* / Q000473:pathology; D002869:Chromosome Aberrations; D004260:DNA Repair / Q000235:genetics; D015321:Gene Rearrangement / Q000235:genetics*; D006801:Humans; D008954:Models, Biological; D008969:Molecular Sequence Data; D013964:Thyroid Neoplasms / Q000235:genetics* / Q000473:pathology