Leptin in non-autoimmune inflammation.
Leptin is an adipokine that modulates multiple functions including energy homeostasis, thermoregulation, bone metabolism, endocrine and pro-inflammatory immune responses. Several studies have implicated leptin in the pathogenesis of chronic autoimmune inflammatory conditions such as autoimmune encephalomyelitis, intestinal bowel inflammation and type-1 diabetes. This review focuses on the role of leptin in non-autoimmune inflammatory diseases that include renal, liver and lung inflammation, atherosclerosis and metabolic syndrome, Behçet's disease and endometriosis.
Cai
Chunlin
C
Department of Medicine, University of California Los Angeles, Los Angeles, California 90095-1670, USA.
Hahn
Bevra H
BH
Matarese
Giuseppe
G
La Cava
Antonio
A
D000818:Animals; D006801:Humans; D007249:Inflammation; D020738:Leptin / Q000235:genetics / Q000276:immunology* / Q000378:metabolism* / Q000627:therapeutic use; D050356:Lipid Metabolism; D008659:Metabolic Diseases / Q000188:drug therapy / Q000276:immunology* / Q000378:metabolism / Q000503:physiopathology; D018384:Oxidative Stress; D011994:Recombinant Proteins / Q000235:genetics / Q000276:immunology* / Q000378:metabolism* / Q000627:therapeutic use
D020738:Leptin; D011994:Recombinant Proteins