title: Regulation of microtubule dynamic instability.
abstract: Proper regulation of MT (microtubule) dynamics is essential for various vital processes, including the segregation of chromosomes, directional cell migration and differentiation. MT assembly and disassembly is modulated by a complex network of intracellular factors that co-operate or antagonize each other, are highly regulated in space and time and are thus attuned to the cell cycle and differentiation processes. While we only begin to appreciate how the concerted action of MT stabilizers and destabilizers shapes different MT patterns, a clear picture of how individual factors affect the MT structure is emerging. In this paper, we review the current knowledge about proteins that modulate MT dynamic instability.
authors.affiliation: Department of Cell Biology, Erasmus Medical Center, Rotterdam, The Netherlands.
authors.forename: Babet
authors.initials: B
authors.lastname: van der Vaart
authors.forename: Anna
authors.initials: A
authors.lastname: Akhmanova
authors.forename: Anne
authors.initials: A
authors.lastname: Straube
mesh_terms: D000818:Animals; D006801:Humans; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D008870:Microtubules / Q000737:chemistry* / Q000378:metabolism* / Q000648:ultrastructure; D011487:Protein Conformation; D014404:Tubulin / Q000378:metabolism
chemical_list: D008869:Microtubule-Associated Proteins; D014404:Tubulin