title: Early bone healing around implant surfaces treated with variations in the resorbable blasting media method. A study in rabbits.
abstract: OBJECTIVE
  this study aimed to histomorphologically and histomorphometrically evaluate the in vivo response to three variations in the resorbable blasting media (RBM) surface processing in a rabbit femur model.
  
  
  METHODS
  screw root form implants with 3.75 mm in diameter by 8 mm in length presenting four surfaces (n=8 each): alumina-blasted/acid-etched (AB/AE), bioresorbable ceramic blasted (TCP), TCP + acid etching, and AB/AE + TCP were characterized by scanning electron microscopy (SEM) and atomic force microscopy (AFM). The implants were placed at the distal femur of 8 New Zeland rabbits, remaining for 2 weeks in vivo. After sacrifice, the implants were nondecalcified processed to 30 micro m thickness slides for histomorphology and bone-to-implant contact (BIC) determination. Statistical analysis was performed by one-way ANOVA at 95% level of significance considering implant surface as the independent variable and BIC as the dependent variable.
  
  
  RESULTS
  SEM and AFM showed that all surfaces presented rough textures and that calciu-hosohate particles were observed at the TCP group surface. Histologic evaluation showed intimate interaction between newly formed woven bone and all implant surfaces, demonstrating that all surfaces were biocompatible and osseoconductive. Significant differences in BIC were observed between the AB/AE and the AB/AE + TCP, and intermediate values observed for the TCP and TCP + Acid surfaces.
  
  
  CONCLUSIONS
  irrespective of RBM processing variation, all surfaces were osseoconductive and biocaompatible. The differences in BIC between groups warrant further bone-implant interface biomechanical characterization.
authors.affiliation: Dept of Biomaterials and Biomimetics, New York University, New York, USA.
authors.forename: Ryan
authors.initials: R
authors.lastname: Jeong
authors.forename: Charles
authors.initials: C
authors.lastname: Marin
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Granato
authors.forename: Marcelo
authors.initials: M
authors.lastname: Suzuki
authors.forename: Jose N
authors.initials: JN
authors.lastname: Gil
authors.forename: Jose M
authors.initials: JM
authors.lastname: Granjeiro
authors.forename: Paulo G
authors.initials: PG
authors.lastname: Coelho
mesh_terms: D000818:Animals; D045662:Dental Etching / Q000379:methods*; D015921:Dental Implants; D005269:Femur / Q000648:ultrastructure; D008855:Microscopy, Electron, Scanning; D011817:Rabbits; D013499:Surface Properties
chemical_list: D015921:Dental Implants