The evaluation of the possibilities of using PLGA co-polymer and its composites with carbon fibers or hydroxyapatite in the bone tissue regeneration process - in vitro and in vivo examinations.
Synthetic polymers belonging to the aliphatic polyester group have become highly promising biomaterials for reconstructive medicine. The purpose of the present work is a biological evaluation of lactide-glycolide co-polymer (PLGA) and its composites with carbon fibers (PLGA+CF) or hydroxyapatite (PLGA+HA). The cytotoxicity of the evaluated materials towards hFOB 1.19 human osteoblast-like cells was assessed. Moreover, during the one-year contact of the assessed materials with living osseous tissue, the progress of bone formation was analyzed and the accompanying process of the materials' degradation was evaluated. The materials under evaluation proved to be biocompatible.
Cieślik
Magdalena
M
Chair and Department of Stomatological Material Science, Pl. Akademicki 17, 41 907 Bytom, Medical University of Silesia, Katowice, Poland.
Mertas
Anna
A
0000-0003-0796-8818
Chair and Department of Microbiology and Immunology, Jordana 19, 41 808 Zabrze, Medical University of Silesia, Katowice, Poland.
Morawska-Chochół
Anna
A
Department of Biomaterials, Faculty of Materials Science and Ceramics, Al. Mickiewicza 30, 30 059 Cracow, AGH University of Science and Technology, Cracow, Poland.
Sabat
Daniel
D
Department and Institute of Pathomorphology, 3maja 13-15, 41 800 Zabrze, Medical University of Silesia, Poland.
Orlicki
Rajmund
R
Chair and Department of Stomatological Material Science, Pl. Akademicki 17, 41 907 Bytom, Medical University of Silesia, Katowice, Poland.
Owczarek
Aleksander
A
Division of Statistics, Ostrogórska 30, 95 010 Sosnowiec, Medical University of Silesia, Katowice, Poland.
Król
Wojciech
W
Chair and Department of Microbiology and Immunology, Jordana 19, 41 808 Zabrze, Medical University of Silesia, Katowice, Poland.
Cieślik
Tadeusz
T
Department and Clinic of Maxillofacial Surgery, Francuska 20/24, 40 027 Katowice, Medical University of Silesia, Katowice, Poland.
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000633:toxicity; D002244:Carbon / Q000737:chemistry* / Q000633:toxicity; D000077482:Carbon Fiber; D002470:Cell Survival; D002478:Cells, Cultured; D017886:Durapatite / Q000737:chemistry* / Q000633:toxicity; D006801:Humans; D019344:Lactic Acid / Q000737:chemistry* / Q000633:toxicity; D008334:Mandible / Q000187:drug effects / Q000502:physiology; D016348:Osseointegration; D010006:Osteoblasts / Q000187:drug effects / Q000378:metabolism; D011100:Polyglycolic Acid / Q000737:chemistry* / Q000633:toxicity; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011817:Rabbits
D001672:Biocompatible Materials; D000077482:Carbon Fiber; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D002244:Carbon; D017886:Durapatite