title: Chrotacumines A-D, chromone alkaloids from Dysoxylum acutangulum.
abstract: Four new chromone alkaloids, chrotacumines A-D (1-4), consisting of a 5,7-dihydroxy-2-methylchromone, an N-Me piperidine ring, and an ester side chain were isolated from Dysoxylum acutangulum, and their structures including absolute configurations were elucidated on the basis of spectroscopic data interpretation including 2D NMR, CD spectra, and X-ray analysis. The known compound rohitukine (5) showed moderate cytotoxicity against human HL-60 promyelocytic leukemia and HCT-116 colon cancer cells.
authors.affiliation: Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-ku, Tokyo 142-8501, Japan.
authors.forename: Intan Safinar
authors.initials: IS
authors.lastname: Ismail
authors.forename: Yuta
authors.initials: Y
authors.lastname: Nagakura
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Hirasawa
authors.forename: Takahiro
authors.initials: T
authors.lastname: Hosoya
authors.forename: Mohd Izwan Mohd
authors.initials: MI
authors.lastname: Lazim
authors.forename: Nordin Hj
authors.initials: NH
authors.lastname: Lajis
authors.forename: Motoo
authors.initials: M
authors.lastname: Shiro
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Morita
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002867:Chromones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D045325:HCT116 Cells; D018922:HL-60 Cells; D006801:Humans; D008296:Malaysia; D029582:Meliaceae / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D002867:Chromones