title: ACHN-490, a neoglycoside with potent in vitro activity against multidrug-resistant Klebsiella pneumoniae isolates.
abstract: The in vitro activity of ACHN-490, a novel aminoglycoside ("neoglycoside"), was evaluated against 102 multidrug-resistant (MDR) Klebsiella pneumoniae strains, including a subset of 25 strains producing the KPC carbapenemase. MIC50 values for gentamicin, tobramycin, and amikacin were 8 microg/ml, 32 microg/ml, and 2 microg/ml, respectively; MIC90 values for the same antimicrobials were > or = 64 microg/ml, > or = 64 microg/ml, and 32 microg/ml, respectively. ACHN-490 showed an MIC50 of 0.5 microg/ml and an MIC90 of 1 microg/ml, which are significantly lower than those of comparator aminoglycosides. ACHN-490 represents a promising aminoglycoside for the treatment of MDR K. pneumoniae isolates, including those producing KPC beta-lactamase.
authors.affiliation: Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio 44106, USA. aendimiani@gmail.com
authors.forename: Andrea
authors.initials: A
authors.lastname: Endimiani
authors.forename: Kristine M
authors.initials: KM
authors.lastname: Hujer
authors.forename: Andrea M
authors.initials: AM
authors.lastname: Hujer
authors.forename: Eliana S
authors.initials: ES
authors.lastname: Armstrong
authors.forename: Yuvraj
authors.initials: Y
authors.lastname: Choudhary
authors.forename: James B
authors.initials: JB
authors.lastname: Aggen
authors.forename: Robert A
authors.initials: RA
authors.lastname: Bonomo
mesh_terms: D000617:Aminoglycosides / Q000737:chemistry / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D024901:Drug Resistance, Multiple, Bacterial; D007711:Klebsiella pneumoniae / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents