De novo intraepidermal epithelioid melanocytic dysplasia: a review of 263 cases.
BACKGROUND
De novo intraepidermal epithelioid melanocytic dysplasia (DNIEMD) is a newly characterized lesion that is associated with a personal and/or family history of malignant melanoma (MM) and/or dysplastic nevi (DN). However, the biological significance is still uncertain and the persons predisposed to this lesion have not been adequately described.


METHODS
Clinicopathologic data of 258 patients, from 263 biopsies diagnosed with DNIEMD, was obtained. A brief voluntary questionnaire was used to obtain demographic, risk factor and disease history.


RESULTS
There is an 82% (n=263) predominance of women with DNIEMDs. For men and women, the distributions of these lesions occur on the lower extremities (71%), the upper extremities (24%) and trunk (5%). Thirty-one percent of the 258 patients responded to the questionnaires. 48% of the 60 respondents had green or blue eyes. 26% of 62 respondents had a history of non-melanoma skin cancer (NMSC). Combined data revealed that 68% of 134 patients had a history of DN. As well, 24% of 89 patients had personal histories of melanoma, while 24% of 72 patients had a family history of melanoma.


CONCLUSIONS
Most of these DNIEMD lesions are found on the lower extremities of women and men, and they have an increased association with MM, DN and NMSC.
Jessup
Chad J
CJ
Department of Pathology Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA 02215, USA. cjessup@bidmc.harvard.edu
Cohen
Lisa M
LM
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D016208:Databases, Factual; D004416:Dysplastic Nevus Syndrome / Q000473:pathology*; D015622:Epithelioid Cells / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008544:Melanocytes / Q000473:pathology*; D008875:Middle Aged; D009508:Nevus, Pigmented / Q000473:pathology*; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors; D012871:Skin Diseases / Q000473:pathology*; D011795:Surveys and Questionnaires