title: Urethral instability: current pathophysiological concept.
abstract: The role of urethral pressure variations during filling cystometry is seldom assessed as a potential cause of voiding dysfunction and/or storage disorders. In this article, we review current research in the field of urethral pressure variations and discuss the way of determining urethral pressure variations, its value for the clinical practice and hypothesize the origin of urethral pressure variations. The observation and recognition of urethral pressure variations (urethral instability) could be valuable in the diagnosis and evaluation of therapy in functional lower urinary tract disorders.
authors.affiliation: Department of Urology, Leiden University Medical Center, Leiden, The Netherlands. groenenp@rdgg.nl
authors.forename: P M
authors.initials: PM
authors.lastname: Groenendijk
authors.forename: J P F A
authors.initials: JP
authors.lastname: Heesakkers
authors.forename: T J
authors.initials: TJ
authors.lastname: Ouwerkerk
authors.forename: A A B
authors.initials: AA
authors.lastname: Lycklama A Nijeholt
mesh_terms: D006801:Humans; D011312:Pressure; D009626:Terminology as Topic; D014521:Urethra / Q000503:physiopathology*; D014522:Urethral Diseases / Q000150:complications / Q000503:physiopathology; D014563:Urodynamics