Clinicopathological features of signet-ring cell carcinoma of the colon and rectum: a case-matched study.
OBJECTIVE
Primary colorectal signet-ring cell carcinoma (SRC) is a rare type of mucin-containing adenocarcinoma and little information exists about its clinicopathological features.


METHODS
The clinicopathological features of 27 patients with primary colorectal SRC were compared with non-signet-ring cell mucinous carcinoma (MC) and non-mucinous adenocarcinoma (NMC). To analyze survival and recurrence, we used matched control groups.


RESULTS
The mean age of patients in SRC was significantly younger than that of NMC (p = 0.003). The ratio of metastatic lymph nodes to harvested lymph nodes was also significantly higher in SRC (48.5 +/- 30.6) than in either MC (29.8 +/- 26.3; p = 0.009) or NMC (22.0 +/- 21.6; p = 0.003). In stage II and III, SRC was found to be associated with a worse cancer-specific survival and a higher systemic recurrence rates than either NMC or MC.


CONCLUSIONS
Primary colorectal SRC has distinctive clinicopathological features and is associated with a poorer prognosis than the other histological subtypes.
Min
Byung Soh
BS
Department of Surgery, College of Medicine, Yonsei University, Seoul, Korea.
Kim
Nam Kyu
NK
Ko
Yong Taek
YT
Baek
Seung Hyuk
SH
Lee
Kang Young
KY
Sohn
Seung Kook
SK
Cho
Chang Hwan
CH
Kang
Dae Ryong
DR
D002288:Adenocarcinoma, Mucinous / Q000473:pathology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D018279:Carcinoma, Signet Ring Cell / Q000473:pathology*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D015179:Colorectal Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D015996:Survival Rate