Anti-inflammatory activity of a HPLC-fingerprinted aqueous infusion of aerial part of Bidens tripartita L.
The anti-inflammatory potential of three doses of an aqueous infusion of aerial parts Bidens tripartita L. against carrageenan-induced acute paw edema in rats was investigated. A phytochemical study and qualitative-quantitative analyses revealed the presence of flavonoids, tannins, polysaccharides, phenols, amino acids, ascorbic acid, organic acids and polyacetylenes. Infusion doses of 20ml/kgbody wt. exhibited significant anti-inflammatory activity in rats, as compared with indomethacin. In addition, the infusion showed analgesic properties in a hot-plate test and antipyretic properties in carrageenan-induced local hyperthermia, both in rats. The effects were dose-dependent. Our results provide evidence for the potential usefulness of B. tripartita infusion in the treatment of inflammatory disorders.
Pozharitskaya
O N
ON
Interregional Fund Adaptation, 1, Ushakova, 188800, Vyborg, Leningrad Region, Russia.
Shikov
A N
AN
Makarova
M N
MN
Kosman
V M
VM
Faustova
N M
NM
Tesakova
S V
SV
Makarov
V G
VG
Galambosi
B
B
D000700:Analgesics / Q000032:analysis / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000032:analysis / Q000494:pharmacology / Q000627:therapeutic use*; D031176:Bidens / Q000737:chemistry*; D002351:Carrageenan; D002851:Chromatography, High Pressure Liquid; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D005260:Female; D005334:Fever / Q000139:chemically induced / Q000188:drug therapy*; D006358:Hot Temperature; D007213:Indomethacin; D010146:Pain / Q000188:drug therapy*; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D002351:Carrageenan; D007213:Indomethacin