title: Clinicopathological features of signet-ring cell carcinoma of the colon and rectum: a case-matched study.
abstract: OBJECTIVE
  Primary colorectal signet-ring cell carcinoma (SRC) is a rare type of mucin-containing adenocarcinoma and little information exists about its clinicopathological features.
  
  
  METHODS
  The clinicopathological features of 27 patients with primary colorectal SRC were compared with non-signet-ring cell mucinous carcinoma (MC) and non-mucinous adenocarcinoma (NMC). To analyze survival and recurrence, we used matched control groups.
  
  
  RESULTS
  The mean age of patients in SRC was significantly younger than that of NMC (p = 0.003). The ratio of metastatic lymph nodes to harvested lymph nodes was also significantly higher in SRC (48.5 +/- 30.6) than in either MC (29.8 +/- 26.3; p = 0.009) or NMC (22.0 +/- 21.6; p = 0.003). In stage II and III, SRC was found to be associated with a worse cancer-specific survival and a higher systemic recurrence rates than either NMC or MC.
  
  
  CONCLUSIONS
  Primary colorectal SRC has distinctive clinicopathological features and is associated with a poorer prognosis than the other histological subtypes.
authors.affiliation: Department of Surgery, College of Medicine, Yonsei University, Seoul, Korea.
authors.forename: Byung Soh
authors.initials: BS
authors.lastname: Min
authors.forename: Nam Kyu
authors.initials: NK
authors.lastname: Kim
authors.forename: Yong Taek
authors.initials: YT
authors.lastname: Ko
authors.forename: Seung Hyuk
authors.initials: SH
authors.lastname: Baek
authors.forename: Kang Young
authors.initials: KY
authors.lastname: Lee
authors.forename: Seung Kook
authors.initials: SK
authors.lastname: Sohn
authors.forename: Chang Hwan
authors.initials: CH
authors.lastname: Cho
authors.forename: Dae Ryong
authors.initials: DR
authors.lastname: Kang
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000473:pathology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D018279:Carcinoma, Signet Ring Cell / Q000473:pathology*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D015179:Colorectal Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D015996:Survival Rate