Factors associated with potential medication-herb/natural product interactions in a rural community.
BACKGROUND
Use of both conventional medicines and herbs/natural products are increasing in the United States. Consequently, individuals are more likely to be exposed to potentially harmful interactions between these products.


OBJECTIVE
To examine the use of both herbs/natural products and conventional medications in a rural community, examine the prevalence of potential interactions between herbs/natural products and conventional medications, and identify factors associated with exposure to such interactions.


METHODS
Population-based epidemiological study.


METHODS
Data for this paper were collected between 1999 and 2004 as part of the Johnston County Osteoarthritis Project.


METHODS
Limited to civilian, noninstitutionalized, white or African American residents, aged 45 years or older, of Johnston County, North Carolina. Data used in this paper are from 2523 individuals who completed face-to-face interviews.


METHODS
Prevalence of herb/natural product use and exposure to potential interactions between these products and conventional medications.


RESULTS
Nineteen percent (n=488) of participants used at least 1 herb/natural product. Among those who used both conventional medications and herbs/natural products, more than 1 in 5 (97 [21.9%]) were using a combination of products associated with a potential interaction. Odds of exposure to a potential interaction were lower among people who had health insurance and increased with the number of products used.


CONCLUSIONS
Many people are exposed to potential interactions between herbs/natural products and conventional medications. Research is needed to better understand the effect such interactions may have on patient care.
Blalock
Susan J
SJ
Division of Pharmaceutical Outcomes and Policy, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, USA.
Gregory
Philip J
PJ
Patel
Rajul A
RA
Norton
Linda L
LL
Callahan
Leigh F
LF
Jordan
Joanne M
JM
D000368:Aged; D000369:Aged, 80 and over; D016001:Confidence Intervals; D019587:Dietary Supplements / Q000706:statistics & numerical data; D016021:Epidemiologic Studies; D005260:Female; D015438:Health Behavior; D019538:Health Care Surveys; D041743:Herb-Drug Interactions; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D004366:Nonprescription Drugs / Q000627:therapeutic use*; D009657:North Carolina / Q000453:epidemiology; D008517:Phytotherapy / Q000706:statistics & numerical data*; D010946:Plants, Medicinal; D012111:Residence Characteristics; D012423:Rural Health; D012424:Rural Population / Q000706:statistics & numerical data*; D012651:Self Medication / Q000706:statistics & numerical data*
D004366:Nonprescription Drugs