Stereocontrolled synthesis of oligodeoxyribonucleoside boranophosphates via stereodefined H-phosphonate intermediates.
P-Stereodefined oligodeoxyribonucleoside boranophosphates (PB-ODNs) were successfully synthesized by the conversion of diastereopure H-phosphonate intermediates. Thermal denaturation studies clearly showed that the duplex stability of PB-ODNs with the complementary DNA and RNA depends on the stereochemistry of the boranophosphate linkages.
Iwamoto
Naoki
N
Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba 277-8562, Japan.
Oka
Natsuhisa
N
Wada
Takeshi
T
D001880:Boranes / Q000737:chemistry*; D003853:Deoxyribonucleosides / Q000737:chemistry; D009691:Nucleic Acid Denaturation; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D063065:Organophosphonates / Q000737:chemistry*; D013237:Stereoisomerism
D001880:Boranes; D003853:Deoxyribonucleosides; D009838:Oligodeoxyribonucleotides; D063065:Organophosphonates