Clinical trial: the efficacy and safety of routine bowel cleansing agents for elective colonoscopy in persons with spinal cord injury - a randomized prospective single-blind study.
BACKGROUND
As difficulty with evacuation is a common occurrence in individuals with spinal cord injury, preparation prior to colonoscopy may be suboptimal and, perhaps, more hazardous.


OBJECTIVE
To assess the safety and efficacy of bowel cleansing regimens in persons with spinal cord injury.


METHODS
Randomized, prospective, single blind study comparing polyethylene glycol (PEG), oral sodium phosphosoda (OSPS) and combination of both for colonic preparation prior to colonoscopy in subjects with spinal cord injury.


RESULTS
Thirty six subjects with eGFR > or =60 mL/min/1.73 m(2) were randomized to PEG or OSPS or PEG+OSPS. Regardless of bowel preparation employed, >73% of subjects had unacceptable colonic cleansing. No subject in the OSPS preparation group demonstrated a decrease in eGFR or an increase in serum creatinine concentration from the baseline. OSPS and PEG+OSPS preparations caused a transient change in serum potassium, phosphate and calcium concentrations, but no change in electrolytes was noted in the PEG group.


CONCLUSIONS
Neither OSPS alone, PEG alone nor their combination was sufficient to prepare adequately the bowel for colonoscopy in most patients with spinal cord injury. However, administration of OSPS and/or PEG appears to be safe in the spinal cord injury population, provided adequate hydration is provided.
Ancha
H R
HR
RR&D Center of Excellence for Medical Consequences of Spinal Cord Injury, James J. Peters VA Medical Center, Bronx, NY 10468, USA.
Spungen
A M
AM
Bauman
W A
WA
Rosman
A S
AS
Shaw
S
S
Hunt
K K
KK
Post
J B
JB
Galea
M
M
Korsten
M A
MA
D000328:Adult; D000368:Aged; D002400:Cathartics / Q000009:adverse effects*; D003106:Colon / Q000473:pathology*; D003110:Colonic Neoplasms / Q000175:diagnosis*; D003113:Colonoscopy / Q000379:methods; D003404:Creatinine / Q000097:blood*; D055088:Early Detection of Cancer / Q000379:methods; D005260:Female; D006801:Humans; D007668:Kidney / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D011092:Polyethylene Glycols / Q000009:adverse effects*; D011300:Preoperative Care; D016037:Single-Blind Method; D013124:Spinal Injuries / Q000150:complications*; D007507:Therapeutic Irrigation / Q000379:methods
D002400:Cathartics; D011092:Polyethylene Glycols; D003404:Creatinine