title: Carbapenem resistance in Acinetobacter baumannii: the molecular epidemic features of an emerging problem in health care facilities.
abstract: Acinetobacter baumannii is an opportunistic gram-negative pathogen with increasing relevance in a variety of nosocomial infections especially among intensive-care-unit (ICU) patients. Carbapenems have been widely used to treat serious multidrug-resistant A. baumannii infections; however, incidences of carbapenem-resistant A. baumannii are rising in several parts of the world and large and sustained outbreaks caused by such bacteria have been described. Carbapenem-resistant A. baumannii epidemics are sustained by clusters of highly similar strains that successfully spread among different cities and countries; their resistance phenotype is mainly due to the acquisition of carbapenem-hydrolyzing class D beta-lactamase (CHDL) genes flanked by insertion sequence (IS) elements. Multi-facility outbreaks can be also sustained by inter-hospital transfer of colonized patients. Here, we review the global epidemiology of carbapenem-resistant A. baumannii, with the emphasis on the molecular epidemiology and genetic characterization of carbapenem resistance in epidemic strains.
authors.affiliation: Department of Preventive Medical Sciences, Hygiene Section, University of Naples Federico II, Naples, Italy. rafzarri@unina.it
authors.forename: Raffaele
authors.initials: R
authors.lastname: Zarrilli
authors.forename: Maria
authors.initials: M
authors.lastname: Giannouli
authors.forename: Federica
authors.initials: F
authors.lastname: Tomasone
authors.forename: Maria
authors.initials: M
authors.lastname: Triassi
authors.forename: Athanassios
authors.initials: A
authors.lastname: Tsakris
mesh_terms: D000151:Acinetobacter Infections / Q000453:epidemiology / Q000382:microbiology; D040981:Acinetobacter baumannii / Q000187:drug effects*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D015780:Carbapenems / Q000494:pharmacology*; D003428:Cross Infection / Q000453:epidemiology / Q000382:microbiology; D004196:Disease Outbreaks; D006801:Humans; D018440:beta-Lactam Resistance
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems