title: Clinical course and spectrum of intensive care unit patients reactivating herpes simplex-1 virus: a retrospective analysis.
abstract: BACKGROUND
  Herpes simplex-1 virus (HSV-1) reactivation in the respiratory tract is common in intensive care unit (ICU) patients. However, susceptible ICU populations are poorly defined. Clinical recognition of HSV infection of the respiratory tract is difficult and the impact of such reactivation is not understood.
  
  
  METHODS
  A retrospective analysis of HSV-1 positive patients encountered over a 5-year period at a multispecialty ICU was carried out. HSV-1 was identified in respiratory secretions using a qualitative polymerase chain reaction (PCR) technique. Patient charts were reviewed for clinical features that would typify HSV-1 respiratory involvement, and the morbidity and mortality risks found with HSV-1 respiratory involvement.
  
  
  RESULTS
  A review of 48 HSV-1 positive ICU patients showed that patients reactivating HSV in the respiratory tract fell into one of the three categories: (1) septic elderly patients with and without ARDS, (2) immunosuppressed patients, especially those receiving high-dose steroids, and (3) post-thoracotomy patients. Abnormalities suggestive of HSV-1 reactivation in the respiratory tract included, haemorrhagic or excessive respiratory secretions, concomitant orofacial herpes (42%), and bronchoscopic abnormalities (hemorrhagic ulcers and mucosal friability) (83%). Twenty eight percent of the HSV-1 infected patients experienced postextubation stridor. HSV-1 reactivation was associated with extended ventilator stays, significant mortality (42%), and ventilator-associated pneumonias (52%).
  
  
  CONCLUSIONS
  Identification of susceptible populations and definition of clinical features of HSV-1 related respiratory disease can enable diagnosis of HSV-1 infection in ICU patients. Although detection by a PCR technique can rapidly diagnose HSV-1 reactivation, prospective studies are required to clarify HSV disease versus mere shedding, and understand the impact of HSV-1 reactivation in hospitalized patients.
authors.affiliation: Department of Medicine, Utah Valley Reginal Medical Center, Provo, Utah, USA. krishna.sundar@imail.org
authors.forename: Krishna M
authors.initials: KM
authors.lastname: Sundar
authors.forename: Karl A
authors.initials: KA
authors.lastname: Ludwig
authors.forename: William T
authors.initials: WT
authors.lastname: Alward
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Pearce
authors.forename: Clark T
authors.initials: CT
authors.lastname: Bishop
authors.forename: Roy C
authors.initials: RC
authors.lastname: Hammond
authors.forename: David R
authors.initials: DR
authors.lastname: Hillyard
authors.forename: Steven W
authors.initials: SW
authors.lastname: Freestone
authors.forename: Anne
authors.initials: A
authors.lastname: Ozment
authors.forename: Barbara C
authors.initials: BC
authors.lastname: Cahill