PPARs and adipocyte function.
For long viewed as passive lipid storage depots, adipocytes are now recognised as key players in the pathogenesis of insulin resistance and metabolic disease. In parallel, the last two decades of research have seen the emergence of transcription factors of the peroxisome proliferator-activated receptor (PPAR) family as central regulators of lipid and glucose homeostasis and molecular targets for drugs to treat hyper-lipidaemia and type 2 diabetes mellitus. In this review we discuss the characteristics of PPARs and the role of the different isotypes in adipocyte biology.
Christodoulides
Constantinos
C
Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford OX3 7LJ, UK. constantinos.christodoulides@orh.nhs.uk
Vidal-Puig
Antonio
A
D017667:Adipocytes / Q000502:physiology*; D000818:Animals; D003920:Diabetes Mellitus / Q000378:metabolism*; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D047492:Peroxisome Proliferator-Activated Receptors / Q000378:metabolism*
D047492:Peroxisome Proliferator-Activated Receptors