Are recently identified genetic variants regulating BMI in the general population associated with anorexia nervosa?
The influence of body mass index (BMI) on susceptibility to anorexia nervosa (AN) is not clear. Recently published genome-wide association (GWA) studies of the general population identified several variants influencing BMI. We genotyped these variants in an AN sample to test for association and to investigate a combined effect of BMI-increasing alleles (as determined in the original GWA studies) on the risk of developing the disease. Individual single nucleotide polymorphisms (SNPs) were tested for association with AN in a sample of 267 AN patients and 1,636 population controls. A logistic regression for the combined effect of BMI-increasing alleles included 225 cases and 1,351 controls. We found no significant association between individual SNPs and AN. The analysis of a combined effect of BMI-increasing alleles showed absence of association with the investigated condition. The percentages of BMI-increasing alleles were equal between cases and controls. This study found no evidence that genetic variants regulating BMI in the general population are significantly associated with susceptibility to AN.
Brandys
Marek K
MK
Department of Neuroscience & Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands.
van Elburg
Annemarie A
AA
Department of Child and Adolescent Psychiatry, University Medical Centre, Utrecht, The Netherlands.|Rintveld Centre for Eating Disorders, Altrecht Mental Health Institute, Zeist, The Netherlands.
Loos
Ruth J F
RJF
Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.
Bauer
Florianne
F
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.|Complex Genetics Section, Department of Medical Genetics-DBG, University Medical Center Utrecht, Utrecht, The Netherlands.
Hendriks
Judith
J
Department of Neuroscience & Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands.
van der Schouw
Yvonne T
YT
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
Adan
Roger A H
RAH
Department of Neuroscience & Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands.
D000328:Adult; D000483:Alleles; D000856:Anorexia Nervosa / Q000235:genetics*; D015992:Body Mass Index; D016022:Case-Control Studies; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012044:Regression Analysis