title: Radiation recall reaction induced by adjuvant trastuzumab (herceptin).
abstract: Although concerns of radiation sensitization have been raised with concurrent trastuzumab (Herceptin) administration, there has been no published case of radiation recall reaction associated with trastuzumab. This case describes a clinical presentation consistent with a radiation recall reaction following administration of adjuvant trastuzumab after neoadjuvant FEC-D chemotherapy and locoregional radiotherapy for HER2-positive, locally advanced breast cancer in a premenopausal woman. Although the mechanism and etiology of radiation recall dermatitis remain unclear, this case raises further hypotheses regarding a possible drug dose-dependence and possible predisposing risk factor for the development of radiation recall reactions.
authors.affiliation: Department of Radiation Oncology, BC Cancer Agency, University of British Columbia, Vancouver, Canada V5Z 4E6.
authors.forename: Caroline
authors.initials: C
authors.lastname: Chung
authors.forename: David
authors.initials: D
authors.lastname: Stuart
authors.forename: Mira
authors.initials: M
authors.lastname: Keyes