title: Surgical dilemma: liver resection or liver transplantation for hepatocellular carcinoma and cirrhosis. Intention-to-treat analysis in patients within and outwith Milan criteria.
abstract: BACKGROUND
  The optimal role of surgery in the management of hepatocellular carcinoma (HCC) is in continuous evolution.
  
  
  OBJECTIVE
  The objective of this study was to analyse survival rates after liver resection (LR) and orthotopic liver transplantation (OLT) for HCC within and outwith Milan criteria in an intention-to-treat analysis.
  
  
  METHODS
  During 1997-2007, 179 patients with cirrhosis and HCC either underwent LR (n= 60) or were listed for OLT (n= 119). Patients with incidental HCC after OLT, preoperative macrovascular invasion before LR, non-cirrhosis and Child-Pugh class C cirrhosis prior to OLT were eliminated, leaving 51 patients primarily treated with LR and 106 patients listed for primary OLT (84 of whom were transplanted) to be included in this analysis. A total of 66 patients fell outwith Milan criteria (26 LR, 40 OLT) and 91 continued to meet Milan criteria (25 LR, 66 OLT).
  
  
  RESULTS
  The median length of follow-up was 26 months. The mean waiting time for OLT was 7 months. During that time, 21 patients were removed from the waiting list as a result of tumour progression. Probabilities of dropout were 2% and 13% at 6 and 12 months, respectively, for patients within Milan criteria, and 34% and 57% at 6 and 12 months, respectively, for patients outwith Milan criteria (P < 0.01). Tumour size >3 cm was found to be the independent factor associated with dropout (hazard ratio [HR] 6.0). Postoperative survival was slightly higher after OLT, but this was not statistically significant (64% for OLT vs. 57% for LR). Overall survival from time of listing for OLT or LR did not differ between the two groups (P= 0.9); for patients within Milan criteria, 1- and 4-year survival rates after LR were 88% and 61%, respectively, compared with 92% and 62%, respectively, after OLT (P= 0.54). For patients outwith Milan criteria, 1- and 4-year survival rates after LR were 69% and 54%, respectively, compared with 65% and 40%, respectively, after OLT (P= 0.42). Tumour size >3 cm was again found to be an independent factor for poor outcome (HR 2.4) in the intention-to-treat analysis.
  
  
  CONCLUSIONS
  Survival rates for patients with HCC are similar in LR and OLT. Liver resection can potentially decrease the dropout rate and serve as a bridge for future salvage LT, particularly in patients with tumours >3 cm.
authors.affiliation: Liver Transplant and Hepatobiliary Service, Westchester Medical Center, New York Medical College, Valhalla, NY, USA. facciutom@wcmc.com
authors.forename: Marcelo E
authors.initials: ME
authors.lastname: Facciuto
authors.forename: Caroline
authors.initials: C
authors.lastname: Rochon
authors.forename: Mahima
authors.initials: M
authors.lastname: Pandey
authors.forename: Manuel
authors.initials: M
authors.lastname: Rodriguez-Davalos
authors.forename: Susana
authors.initials: S
authors.lastname: Samaniego
authors.forename: David C
authors.initials: DC
authors.lastname: Wolf
authors.forename: Leona
authors.initials: L
authors.lastname: Kim-Schluger
authors.forename: Grigory
authors.initials: G
authors.lastname: Rozenblit
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Sheiner