title: Bovine immunodeficiency virus produces a transient viraemic phase soon after infection in Bos javanicus.
abstract: Infection of Bali cattle (Bos javanicus) in Indonesia with a non-pathogenic bovine lentivirus similar to Bovine immunodeficiency virus (BIV) is suspected but efforts to detect the virus have been unsuccessful. To define the kinetics of BIV infection in Bali cattle, 13 were infected with the R-29 strain of BIV and monitored for 60 days. No clinical effects were detected. Proviral DNA was detected in peripheral blood mononuclear cells from 4 to 60 days with peak titres 20 days post-infection (dpi). There was a transient viraemia from 4 to 14 dpi with a maximum titre of 1x10(4)genome copies/ml plasma. An antibody response to the transmembrane (TM) glycoprotein commenced 12 dpi but an antibody response to the capsid (CA) protein was detected in one animal only and not until 34 dpi. The results indicated that detection of BIV in infected Bali cattle would have a greater chance of success soon after infection and prior to the onset of a CA antibody response.
authors.affiliation: School of Veterinary and Biomedical Science, Murdoch University, Murdoch, WA 6150, Australia.
authors.forename: Tegan
authors.initials: T
authors.lastname: McNab
authors.forename: Moira
authors.initials: M
authors.lastname: Desport
authors.forename: W Masa
authors.initials: WM
authors.lastname: Tenaya
authors.forename: Nining
authors.initials: N
authors.lastname: Hartaningsih
authors.forename: Graham E
authors.initials: GE
authors.lastname: Wilcox
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000821:virology*; D004279:DNA, Viral / Q000097:blood; D016087:Immunodeficiency Virus, Bovine / Q000502:physiology*; D016180:Lentivirus Infections / Q000662:veterinary* / Q000821:virology; D011533:Proviruses; D012367:RNA, Viral / Q000097:blood; D013997:Time Factors; D019562:Viral Load
chemical_list: D004279:DNA, Viral; D012367:RNA, Viral