title: Risk of malignant pleural mesothelioma and polymorphisms in genes involved in the genome stability and xenobiotics metabolism.
abstract: Malignant pleural mesothelioma (MPM) is a rare and aggressive cancer mostly attributable to asbestos exposure. Many polymorphic genes encoding for xenobiotic and oxidative metabolism enzymes (XME) or involved in genome stability (GS) can modulate individual MPM risk in exposed populations. An association study was carried out in a case-control setting including 119 MPM patients and two groups of referent subjects (104 with and 695 without documented asbestos exposure). Forty-eight polymorphisms in XME genes and 75 in GS-genes were evaluated. Statistical analysis revealed some significant associations of studied polymorphisms with MPM risk, but most of them disappeared after applying Bonferroni correction (new threshold for statistical significance: p=4.07 x 10(-4)). On the other hand, the nucleotidic change 282C>T within NAT2 held the statistical significance (OR=3.54; 95% CI 1.75-7.16; p=0.0002), reinforcing existing evidences that describe genetic polymorphisms of NAT2 possibly involved in the etiology of the MPM.
authors.affiliation: Genetics - Department of Biology, University of Pisa, Via Derna, 1, 56100 Pisa, Italy.
authors.forename: Federica
authors.initials: F
authors.lastname: Gemignani
authors.forename: Monica
authors.initials: M
authors.lastname: Neri
authors.forename: Fabio
authors.initials: F
authors.lastname: Bottari
authors.forename: Roberto
authors.initials: R
authors.lastname: Barale
authors.forename: Pier Aldo
authors.initials: PA
authors.lastname: Canessa
authors.forename: Federico
authors.initials: F
authors.lastname: Canzian
authors.forename: Marcello
authors.initials: M
authors.lastname: Ceppi
authors.forename: Irene
authors.initials: I
authors.lastname: Spitaleri
authors.forename: Monica
authors.initials: M
authors.lastname: Cipollini
authors.forename: Gian Paolo
authors.initials: GP
authors.lastname: Ivaldi
authors.forename: Manlio
authors.initials: M
authors.lastname: Mencoboni
authors.forename: Paola
authors.initials: P
authors.lastname: Scaruffi
authors.forename: Gian Paolo
authors.initials: GP
authors.lastname: Tonini
authors.forename: Donatella
authors.initials: D
authors.lastname: Ugolini
authors.forename: Luciano
authors.initials: L
authors.lastname: Mutti
authors.forename: Stefano
authors.initials: S
authors.lastname: Bonassi
authors.forename: Stefano
authors.initials: S
authors.lastname: Landi
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D005260:Female; D056726:Genetic Association Studies; D042822:Genomic Instability; D006801:Humans; D008297:Male; D008654:Mesothelioma / Q000201:enzymology* / Q000235:genetics*; D008875:Middle Aged; D010997:Pleural Neoplasms / Q000201:enzymology* / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D015262:Xenobiotics / Q000378:metabolism
chemical_list: D015262:Xenobiotics