[Potential value of Mycobacterium tuberculosis RD1 region-encoded proteins in the diagnosis of tuberculosis].
Nine proteins encoded by Mycobacterium tuberculosis RD1 region are important protective antigens that become absent in long passaging of Mycobacterium tuberculosis. They only exist in pathogenic Mycobacteria and are absent in Bacille Calmette-Guerin and environmental Mycobacteria. With good immunogenicities, they may play an important role in the diagnosis and prevention of Mycobacterium tuberculosis. This article reviews recent studies on using RD1-encoded proteins as antigens in the diagnosis of active tuberculosis and tuberculous pleurisy.
Du
Feng-Jiao
FJ
Laboratory of Molecular Biology for Tuberculosis, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China.
Chen
Xi
X
Liu
Fei
F
Zhang
Zong-De
ZD
D000942:Antigens, Bacterial / Q000302:isolation & purification / Q000378:metabolism*; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000502:physiology*; D014376:Tuberculosis / Q000175:diagnosis*
D000942:Antigens, Bacterial; C072681:Mycobacterium tuberculosis antigens