title: Sustained virological response in a predominantly hepatitis C virus genotype 4 infected population.
abstract: OBJECTIVE
  To assess sustained virological response (SVR) rates in a predominantly hepatitis C virus (HCV) genotype 4 infected population.
  
  
  METHODS
  Between 2003-2007, 240 patients who were treated for chronic hepatitis C infection at our center were included. Epidemiological data, viral genotypes, and treatment outcomes were evaluated in all treated patients. Patients with chronic renal failure, previous non-responders, and those who relapsed after previous treatment were excluded from the study. Among all patients, 57% were treated with PEG-interferon (IFN) alpha-2a and 43% patients were treated with PEG-IFN alpha-2b; both groups received a standard dose of ribavirin.
  
  
  RESULTS
  89.6% of patients completed the treatment with an overall SVR rate of 58%. The SVR rate was 54% in genotype 1, 44% in genotype 2, 73% in genotype 3, and 59% in genotype 4 patients. There was no statistical difference in the SVR rate between patients treated with PEG-IFN alpha-2a and PEG-IFN alpha-2b (61.5% vs 53%). Patients younger than 40 years had higher SVR rates than older patients (75% vs 51%, P = 0.001). SVR was also statistically significantly higher when the HCV RNA load (pretreatment) was below 800.000 (64% vs 50%, P = 0.023), in patients with a body mass index (BMI) less than 28 (65% vs 49%, P = 0.01), and in patients who completed the treatment duration (64% vs 8%, P <or= 0.00001).
  
  
  CONCLUSIONS
  The SVR rate in our study is higher than in previous studies. Compliance with the standard duration of treatment, higher ribavirin dose, younger age, lower BMI, and low pretreatment RNA levels were associated with a higher virological response.
authors.affiliation: Gastroenterology and Hepatology Unit, King Abdulaziz Medical City, National Guard Health Affairs, Jeddah 21423, Saudi Arabia. yaserdahlan@hotmail.com
authors.forename: Yaser
authors.initials: Y
authors.lastname: Dahlan
authors.forename: Hafiz-Mughees
authors.initials: HM
authors.lastname: Ather
authors.forename: Majid
authors.initials: M
authors.lastname: Al-ahmadi
authors.forename: Faisal
authors.initials: F
authors.lastname: Batwa
authors.forename: Waleed
authors.initials: W
authors.lastname: Al-hamoudi
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D005838:Genotype; D016174:Hepacivirus / Q000235:genetics* / Q000302:isolation & purification; D006526:Hepatitis C / Q000188:drug therapy* / Q000453:epidemiology / Q000821:virology; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D011092:Polyethylene Glycols / Q000008:administration & dosage*; D012367:RNA, Viral / Q000097:blood; D011994:Recombinant Proteins; D012189:Retrospective Studies; D012254:Ribavirin / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D012367:RNA, Viral; D011994:Recombinant Proteins; D011092:Polyethylene Glycols; D012254:Ribavirin; C417083:peginterferon alfa-2b; C100416:peginterferon alfa-2a