Asymmetric copper-catalyzed propargylic substitution reaction of propargylic acetates with enamines.
Enamines served as carbon-nucleophiles for the first time in the Cu-catalyzed asymmetric propargylic substitution reaction of propargylic acetates, providing corresponding chiral beta-ethynyl-substituted ketones in high yields and in good to high enantioselectivity.
Fang
Ping
P
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, China.
Hou
Xue-Long
XL