In vitro activity of linezolid against Mycobacterium tuberculosis strains isoalted from Western Turkey.
We investigated the linezolid susceptibility of Mycobacterium tuberculosis strains isolated from a tertiary care hospital in Izmir. A total of 67 M. tuberculosis strains (33 multidrug-resistant [MDR] and 34 non-MDR) were isolated and identified by the Tuberculosis Laboratory, Department of Microbiology and Clinical Microbiology, Faculty of Medicine, Ege University. The activity of linezolid was studied by the standard agar proportion method. For all of the strains, the MIC range was 0.06-1 mg/L, and the MIC(50) and MIC(90) values were 0.5 mg/L. No differences were observed between the MDR and non-MDR isolates. In general, linezolid was found to be effective for both the non-MDR and MDR M. tuberculosis strains.
Ermertcan
Safak
S
Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Ege University, Izmir, Turkey. safak.ermertcan@ege.edu.tr
Hosgor-Limoncu
Mine
M
Erac
Bayri
B
Tasli
Huseyin
H
Cavusoglu
Cengiz
C
Bozkurt
Hale
H
D000081:Acetamides / Q000494:pharmacology*; D000995:Antitubercular Agents / Q000494:pharmacology*; D006761:Hospitals; D006801:Humans; D000069349:Linezolid; D008826:Microbial Sensitivity Tests / Q000379:methods; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000302:isolation & purification*; D023303:Oxazolidinones / Q000494:pharmacology*; D014376:Tuberculosis / Q000382:microbiology*; D014421:Turkey
D000081:Acetamides; D000995:Antitubercular Agents; D023303:Oxazolidinones; D000069349:Linezolid