title: Possible importance of increased intra-abdominal pressure for the development of necrotizing enterocolitis.
abstract: OBJECTIVE
  Despite extensive clinical and laboratory investigations, many aspects of the pathogenesis of necrotizing enterocolitis (NEC) remain unclear. In the present work we describe 5 neonates with NEC in whom intra-abdominal pressure (IAP) was measured to investigate the potential role of abdominal compartment syndrome (ACS) in the development of NEC and to correlate the severity of NEC with the value of IAP.
  
  
  METHODS
  IAP pressure was determined in two groups - Group A consisting of five patients without NEC (Control) and Group B consisting of five patients who developed NEC - by measuring the urinary bladder pressure (UBP). The correlation between increased IAP and severity of NEC, complications of NEC and indications for surgery was investigated.
  
  
  RESULTS
  In four patients from Group B, the general condition deteriorated despite aggressive supportive treatment, and a laparotomy was performed. These neonates demonstrated a significant increase (compared to Control patients) in UBP (9.0+/-2.5 vs. 4.8+/-1.4 mmHg, p=0.001), which increased progressively with exacerbation of NEC and reached a peak value of 13.3+/-2.4 mmHg before operation. The elevated IAP was accompanied by hemodynamic instability in all patients, respiratory instability in 3 patients and decreased urinary output in one patient. One patient remained unstable and died 6 h after operation. In the fifth patient from Group B, intestinal obstruction developed two weeks after NEC and did not result in increased IAP.
  
  
  CONCLUSIONS
  Our results suggest that IAP is associated with an exacerbation of NEC. Thus, this study provides further information which may improve our understanding of the pathogenic process of NEC.
authors.affiliation: The Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Laboratory of intestinal adaptation and recovery , Dept of Pediatric Surgery, Bnai Zion Medical Center, Haifa, Israel. igor-dr@internet-zahav.net
authors.forename: I
authors.initials: I
authors.lastname: Sukhotnik
authors.forename: A
authors.initials: A
authors.lastname: Riskin
authors.forename: D
authors.initials: D
authors.lastname: Bader
authors.forename: M
authors.initials: M
authors.lastname: Lieber
authors.forename: B
authors.initials: B
authors.lastname: Shamian
authors.forename: A G
authors.initials: AG
authors.lastname: Coran
authors.forename: J
authors.initials: J
authors.lastname: Mogilner
mesh_terms: D000005:Abdomen; D016022:Case-Control Studies; D003161:Compartment Syndromes / Q000150:complications* / Q000503:physiopathology; D020345:Enterocolitis, Necrotizing / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male