Synthesis and anticancer activity of N-bis(trifluoromethyl)alkyl-N'-thiazolyl and N-bis(trifluoromethyl)alkyl-N'-benzothiazolyl ureas.
A number of N-bis(trifluoromethyl)alkyl-N'-thiazolyl and -benzothiazolyl ureas have been synthesized and evaluated for their in vitro antiproliferative activities against the human cancer cell lines at the National Cancer Institute (NCI, USA). The activity was shown for compounds 8a,c and 9a-c. The most sensitive cell lines relative to the tested compounds are: 8c PC-3 (prostate cancer, logGI(50) -7.10), 9c SNB-75 (CNS cancer, logGI(50) -5.84), 9b UO-31 (renal cancer, logGI(50) -5.66), and SR (leukemia, logGI(50) -5.44) human cancer cells.
Luzina
Elena L
EL
Institute of Physiologically Active Compounds, Severnyi pr. 1, Chernogolovka, Moscow region 142432, Russia. luzina@ipac.ac.ru
Popov
Anatoliy V
AV
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry; D052160:Benzothiazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry*; D015394:Molecular Structure; D014508:Urea / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D000970:Antineoplastic Agents; D052160:Benzothiazoles; D006845:Hydrocarbons, Fluorinated; D014508:Urea