title: Mitral repair versus replacement for ischemic mitral regurgitation: comparison of short-term and long-term survival.
abstract: BACKGROUND
  When compared to mitral valve replacement (MVR), mitral valve repair (MVRp) is associated with better survival in patients with organic mitral regurgitation (MR). However, there is an important controversy about the type of surgical treatment that should be used in patients with ischemic MR. The objective of this study was to compare the postoperative outcome of MVRp versus MVR in patients with ischemic MR.
  
  
  RESULTS
  Preoperative and operative data of 370 patients with ischemic MR who underwent mitral valve surgery were prospectively collected and retrospectively analyzed. MVRp was performed in 50% of patients (n=186) and MVR in 50% (n=184). Although operative mortality was significantly lower after MVRp compared to MVR (9.7% versus 17.4%; P=0.03), overall 6-year survival was not statistically different between procedures (73+/-4% versus 67+/-4%; P=0.17). After adjusting for other risk factors and propensity score, the type of procedure (MVRp versus MVR) did not come out as an independent predictor of either operative (OR, 1.5; 95% CI, 0.7-2.9; P=0.34) or overall mortality (HR, 1.2; 95% CI, 0.7-1.9; P=0.52).
  
  
  CONCLUSIONS
  As opposed to what has been reported in patients with organic MR, the results of this study suggest that MVRp is not superior to MVR with regard to operative and overall mortality in patients with ischemic MR. These findings provide support for the realization of a randomized trial comparing these 2 treatment modalities.
authors.affiliation: Institut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, Canada.
authors.forename: Julien
authors.initials: J
authors.lastname: Magne
authors.forename: Nicolas
authors.initials: N
authors.lastname: Girerd
authors.forename: Mario
authors.initials: M
authors.lastname: Sénéchal
authors.forename: Patrick
authors.initials: P
authors.lastname: Mathieu
authors.forename: François
authors.initials: F
authors.lastname: Dagenais
authors.forename: Jean G
authors.initials: JG
authors.lastname: Dumesnil
authors.forename: Eric
authors.initials: E
authors.lastname: Charbonneau
authors.forename: Pierre
authors.initials: P
authors.lastname: Voisine
authors.forename: Philippe
authors.initials: P
authors.lastname: Pibarot
mesh_terms: D000368:Aged; D005260:Female; D019918:Heart Valve Prosthesis Implantation / Q000379:methods* / Q000401:mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000601:surgery*; D008944:Mitral Valve Insufficiency / Q000401:mortality* / Q000601:surgery*; D017202:Myocardial Ischemia / Q000150:complications*; D012189:Retrospective Studies; D016277:Ventricular Function, Left