[Evaluation of target-controlled infusion for propofol in patients with chronic renal failure undergoing living-related renal transplantation].
BACKGROUND
As we have no information whether target-controlled infusion (TCI) for propofol, using pharmacokinetic parameters obtained without chronic renal failure, is available to estimate the drug concentration, we examined the blood concentration of propofol on the patients with chronic renal failure to evaluate the reliability of TCI of propofol.


METHODS
Ten patients with chronic renal failure undergoing hemodialysis, from 20 to 60 years of age, were scheduled for living-related renal transplantation. Propofol was administrated with our TCI system at the target blood concentration of 4 microg x ml(-1) for three hours. Blood samples were obtained at 30, 60, 90, 120, and 180 minutes after starting propofol delivery, and at the emergence from anesthesia to measure propofol concentration.


RESULTS
There was no tendency of increasing the drug concentration in proportion to the time of propofol infusion. As for the concentration at emergence, mean estimated concentration of propofol was 1.6 mg x ml(-1), showing a good correlation between measured and estimated concentrations.


CONCLUSIONS
TCI system for propofol provided a good estimation of the blood concentration of propofol in patients with chronic renal failure undergoing living-related renal transplantation.
Igarashi
Tae
T
Department of Anesthesia, Saiseikai Kawaguchi General Hospital, Kawaguchi 332-8558.
Nagata
Osamu
O
Iwakiri
Hiroko
H
Ikeda
Misako
M
Ozaki
Makoto
M
D000328:Adult; D000768:Anesthesia, General; D018686:Anesthetics, Intravenous / Q000008:administration & dosage* / Q000097:blood; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous / Q000379:methods; D007676:Kidney Failure, Chronic / Q000601:surgery*; D016030:Kidney Transplantation; D019520:Living Donors; D008297:Male; D015742:Propofol / Q000008:administration & dosage* / Q000097:blood; D055815:Young Adult
D018686:Anesthetics, Intravenous; D015742:Propofol