title: Is antral follicle count a genetic trait?
abstract: OBJECTIVE
  The aim of this study was to determine the relationship between maternal age of menopause and antral follicle count.
  
  
  METHODS
  This was a cross-sectional study of 124 women aged 25 to 48 years presenting with infertility. Women reported their mother's age of menopause and underwent transvaginal ultrasound to assess antral follicle count. Participant age, age greater than 37 years, and maternal age of menopause, as well as interactions among these, were incorporated into a multiple linear regression model to predict antral follicle count. Three different ages of maternal menopause were inputted into this model to illustrate the relationship between maternal age of menopause and rate of decline in antral follicle count.
  
  
  RESULTS
  Women with a lower maternal age of menopause have lower antral follicle counts but also a slower decline until the age of 37 years.
  
  
  CONCLUSIONS
  Maternal age of menopause predicts antral follicle count and its decline, indicating a genetic component to this trait.
authors.affiliation: Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, CA, USA.
authors.forename: Mitchell P
authors.initials: MP
authors.lastname: Rosen
authors.forename: Erica B
authors.initials: EB
authors.lastname: Johnstone
authors.forename: Sara J
authors.initials: SJ
authors.lastname: Gillham
authors.forename: Aisha E
authors.initials: AE
authors.lastname: Modan
authors.forename: Angela K M
authors.initials: AK
authors.lastname: Lipshutz
authors.forename: Renee
authors.initials: R
authors.lastname: Reijo-Pera
authors.forename: Marcelle I
authors.initials: MI
authors.lastname: Cedars
mesh_terms: D000328:Adult; D000367:Age Factors; D000375:Aging / Q000235:genetics*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000000981:diagnostic imaging / Q000235:genetics*; D008593:Menopause / Q000235:genetics; D008875:Middle Aged; D009035:Mothers; D006080:Ovarian Follicle / Q000000981:diagnostic imaging*; D014463:Ultrasonography