title: Association between serum estradiol level and intraocular pressure in postmenopausal women.
abstract: OBJECTIVE
  To evaluate the association between serum estradiol (E2) level and intraocular pressure (IOP) in Korean postmenopausal women
  
  
  METHODS
  From January 2000 to December 2006, serum concentration of E2 and IOP were measured in 8,674 postmenopausal women. Serum concentration of E2 was measured by radioimmunoassay. The IOP was measured using Goldmann's applanation tonometer. All data were analyzed with correlation analysis, Student's t test and analysis of variance.
  
  
  RESULTS
  The mean age of the study subjects was 59.57 +/- 8.54 years. The mean E2 concentration was 22.17 +/- 6.08 pg/mL and the mean IOP was 12.23 +/- 2.20 mm Hg for the average of both eyes. In correlation analysis, no significant association was found between IOP and age or IOP and serum E2 concentration. When we divided a total of 8,674 women into 4 groups according to the E2 concentration (< or = 10, 10-20, 20-30 and >30 pg/mL, respectively), the IOPs of the 4 groups did not differ significantly.
  
  
  CONCLUSIONS
  This study suggests that the IOP in Korean postmenopausal women might not be directly associated with serum E2 concentration.
authors.affiliation: Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
authors.forename: Byung-Moon
authors.initials: BM
authors.lastname: Kang
authors.forename: Yun-Hee
authors.initials: YH
authors.lastname: Koo
authors.forename: Sa-Ra
authors.initials: SR
authors.lastname: Lee
authors.forename: Sung-Hoon
authors.initials: SH
authors.lastname: Kim
authors.forename: Hee-Dong
authors.initials: HD
authors.lastname: Chae
authors.forename: Chung-Hoon
authors.initials: CH
authors.lastname: Kim
mesh_terms: D000368:Aged; D004958:Estradiol / Q000097:blood*; D005260:Female; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology*; D008875:Middle Aged; D017698:Postmenopause / Q000502:physiology*; D014065:Tonometry, Ocular
chemical_list: D004958:Estradiol