title: Noninvasive functional imaging of the retina reveals outer retinal and hemodynamic intrinsic optical signal origins.
abstract: We have adapted intrinsic signal optical imaging of neural activity to the noninvasive functional imaging of the retina. Results to date demonstrate the feasibility and potential of this new method of functional assessment of the retina. In response to visual stimuli, we have imaged reflectance changes in the retina that are robust and spatially colocalized to the sites of stimulation. However, the technique is in its infancy and many questions as to the underlying mechanisms remain. In particular, the source and nature of the activity-dependent intrinsic optical signals in the retina need to be characterized and their anatomic origins determined. The studies described here begin to address these issues. The evidence indicates that the imaged signals are driven by the outer retinal layers and have a dominant hemodynamic component.
authors.affiliation: Department of Neurosurgery, SUNY Upstate Medical University, Syracuse, NY 13210, USA. dan@tsolab.org
authors.forename: Daniel
authors.initials: D
authors.lastname: Ts'o
authors.forename: Jesse
authors.initials: J
authors.lastname: Schallek
authors.forename: Young
authors.initials: Y
authors.lastname: Kwon
authors.forename: Randy
authors.initials: R
authors.lastname: Kardon
authors.forename: Michael
authors.initials: M
authors.lastname: Abramoff
authors.forename: Peter
authors.initials: P
authors.lastname: Soliz
mesh_terms: D000818:Animals; D002415:Cats; D003952:Diagnostic Imaging / Q000295:instrumentation / Q000379:methods*; D004195:Disease Models, Animal; D004596:Electroretinography; D005902:Glaucoma, Open-Angle / Q000503:physiopathology; D006439:Hemodynamics / Q000502:physiology*; D008252:Macaca fascicularis; D010364:Pattern Recognition, Visual / Q000502:physiology; D010775:Photic Stimulation; D012160:Retina / Q000502:physiology*; D012171:Retinal Vessels / Q000502:physiology*; D041623:Tomography, Optical Coherence