Nephrotic syndrome as paraneoplastic manifestation of a primary pulmonary lymphoepithelioma-like carcinoma.
We present a case of nephrotic syndrome secondary to a membranous glomerulonephritis (MG), in a nonsmoking female with a solitary pulmonary nodule, which did not show growth during 2 years of followup. A biopsy by videothoracoscopy showed a granulomatous non-neoplastic process with giant multinucleated cells. The appearance of a nephrotic syndrome and its interpretation as paraneoplastic revealed the existence of a primary pulmonary lymphoepithelioma-like carcinoma (LELC), a very rare pulmonary tumor. After resection of tumor there was a complete recovery from the nephrotic syndrome. This case highlights how the investigation of paraneoplastic syndromes can help in the early diagnosis of some malignancies.
Arenas
M D
MD
Servicio de Nefrologia, Hospital Perpetuo Socorro, Alicante, Spain. arenasd@perpertuosocorro.nehos.com
Gil
M T
MT
Malek
T
T
Farré
J
J
Fernández Morejón
F J
FJ
Arriero
J M
JM
Aranda
I
I
Moledous
A
A
Alvarez-Ude
F
F
D002277:Carcinoma / Q000150:complications*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications*; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000209:etiology*; D010257:Paraneoplastic Syndromes / Q000209:etiology*