Molecular epidemiology of Mycobacterium tuberculosis in a South African community with high HIV prevalence.
To explore the relationship between human immunodeficiency virus (HIV) and Mycobacterium tuberculosis genotypes, we performed IS6110-based restriction fragment-length polymorphism analysis on M. tuberculosis culture specimens from patients with smear-positive tuberculosis in a periurban community in South Africa from 2001 through 2005. Among 151 isolates, 95 strains were identified within 26 families, with 54% clustering. HIV status was associated with W-Beijing strains (P = .009) but not with clustering per se. The high frequency of clustering suggests ongoing transmission in both HIV-negative and HIV-positive individuals in this community. The strong association between W-Beijing and HIV infection may have important implications for tuberculosis control.
Middelkoop
Keren
K
Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, Cape Town, South Africa. keren.middelkoop@hiv-research.org.za
Bekker
Linda-Gail
LG
Mathema
Barun
B
Shashkina
Elena
E
Kurepina
Natalia
N
Whitelaw
Andrew
A
Fallows
Dorothy
D
Morrow
Carl
C
Kreiswirth
Barry
B
Kaplan
Gilla
G
Wood
Robin
R
D005190:Family; D005838:Genotype; D015658:HIV Infections / Q000453:epidemiology*; D006801:Humans; D017720:Molecular Epidemiology; D009169:Mycobacterium tuberculosis / Q000235:genetics*; D010802:Phylogeny; D012150:Polymorphism, Restriction Fragment Length; D015995:Prevalence; D013019:South Africa / Q000453:epidemiology; D014376:Tuberculosis / Q000453:epidemiology* / Q000382:microbiology* / Q000517:prevention & control