title: Tunable Phosphoramidite Ligands for Asymmetric Hydrovinylation: Ligands par excellence for Generation of All-Carbon Quaternary Centers.
abstract: 1-Alkylstyrenes undergo efficient hydrovinylation (addition of ethylene) in the presence of a Ni-catalyst prepared from [(allyl)NiBr](2), Na(+) [BAr(4)](-) (Ar = 3,5-bis-trifluromethylphenyl), and a phosphoramidite ligand giving products in excellent yields and enantioselectivities. In many cases phosphoramidites derived from achiral 2,2'-biphenol are almost as good as ligands derived from the more expensive enantiopure 2,2'-binaphthols. The hydrovinylation products, which carry two versatile latent functionalities, an aryl and a vinyl group, are potentially useful for the synthesis of several important natural products containing benzylic all-carbon quaternary centers.
authors.affiliation: Department of Chemistry, The Ohio State University, 100 W. 18 Ave, Columbus, OHIO 43210, USA.
authors.forename: Craig R
authors.initials: CR
authors.lastname: Smith
authors.forename: Hwan Jung
authors.initials: HJ
authors.lastname: Lim
authors.forename: Aibin
authors.initials: A
authors.lastname: Zhang
authors.forename: T V
authors.initials: TV
authors.lastname: Rajanbabu