title: Alpha-glucosidase inhibitory, aromatase inhibitory, and antiplasmodial activities of a biflavonoid GB1 from Garcinia kola stem bark.
abstract: The biflavonoid, 3'',4',4''',5,5'',7,7''-heptahydroxy-3,8-biflavanone, known as GB1 (1), was isolated as a major constituent from Garcinia kola stem bark. GB1 (1) exhibited alpha-glucosidase and aromatase inhibitory activities, as well as antiplasmodial activity, but was not toxic against cell lines tested. GB1 (1) may be a potential dietary supplement or phytomedicine for the prevention of breast cancer and type 2 diabetes mellitus.
authors.affiliation: Chulabhorn Research Institute, Vibhavadi-Rangsit Highway, Bangkok, Thailand.
authors.forename: Bassey S
authors.initials: BS
authors.lastname: Antia
authors.forename: Acharavadee
authors.initials: A
authors.lastname: Pansanit
authors.forename: Okon D
authors.initials: OD
authors.lastname: Ekpa
authors.forename: Udofot J
authors.initials: UJ
authors.lastname: Ekpe
authors.forename: Chulabhorn
authors.initials: C
authors.lastname: Mahidol
authors.forename: Prasat
authors.initials: P
authors.lastname: Kittakoop
mesh_terms: D000962:Antimalarials / Q000302:isolation & purification / Q000494:pharmacology*; D047072:Aromatase Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D044946:Biflavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D029763:Garcinia kola / Q000737:chemistry*; D065089:Glycoside Hydrolase Inhibitors; D024301:Plant Bark; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018547:Plant Stems
chemical_list: C549907:3',4',4',5,5',7,7'-heptahydroxy-3,8-biflavanone; D000962:Antimalarials; D047072:Aromatase Inhibitors; D044946:Biflavonoids; D004791:Enzyme Inhibitors; D065089:Glycoside Hydrolase Inhibitors; D010936:Plant Extracts