The oxidative stress menace to coronary vasculature: any place for antioxidants?
Oxidative stress is involved in the pathogenesis of atherosclerosis. A variety of antioxidants has been used in clinical studies, during the past few years, for the prevention and treatment of atherosclerosis. In small clinical studies it was found that both vitamins C and E may improve endothelial function in high risk patients. However, interventional trials have been controversial, with some positive findings, many null findings, and some suggestion of harm in certain high-risk populations. Therefore, treatment with antioxidant vitamins C and E should not be recommended for the prevention or treatment of coronary atherosclerosis. New antioxidant strategies are needed to clarify the exact role of antioxidant treatment in coronary atherosclerosis.
Briasoulis
Alexandros
A
1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, 16675, Glifada, Athens, Greece. drtousoulis@hotmail.com.
Tousoulis
Dimitris
D
Antoniades
Charalambos
C
Stefanadis
Christodoulos
C
D000818:Animals; D000975:Antioxidants / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D001205:Ascorbic Acid / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D003324:Coronary Artery Disease / Q000188:drug therapy* / Q000503:physiopathology / Q000517:prevention & control; D004730:Endothelium, Vascular / Q000187:drug effects; D006801:Humans; D018384:Oxidative Stress / Q000187:drug effects*; D012307:Risk Factors; D014810:Vitamin E / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use
D000975:Antioxidants; D014810:Vitamin E; D001205:Ascorbic Acid