title: Three-component synthesis of alpha-branched amines under Barbier-like conditions.
abstract: An array of alpha-branched amines has been prepared by using an expedient three-component Mannich-type reaction among organic halides, aldehyde derivatives, and amines. The experimental procedure, which is characterized by its simplicity, employs zinc dust for the in situ generation of organozinc reagents. We show that this Barbier-like protocol constitutes a useful entry to diarylmethylamines, 1,2-diarylethylamines, alpha- or beta-amino esters, benzylamines, and beta-arylethylamines.
authors.affiliation: Electrochimie et Synthèse Organique, Institut de Chimie et des Matériaux Paris Est-UMR 7182 CNRS-Université Paris 12, 2-8 rue Henri Dunant, 94320 Thiais, France. legall@glvt-cnrs.fr
authors.forename: Erwan
authors.initials: E
authors.lastname: Le Gall
authors.forename: Caroline
authors.initials: C
authors.lastname: Haurena
authors.forename: Stéphane
authors.initials: S
authors.lastname: Sengmany
authors.forename: Thierry
authors.initials: T
authors.lastname: Martens
authors.forename: Michel
authors.initials: M
authors.lastname: Troupel
mesh_terms: D000588:Amines / Q000138:chemical synthesis*; D015394:Molecular Structure
chemical_list: D000588:Amines