title: Efficacy of a topical ectoparasiticide containing dinotefuran, pyriproxyfen, and permethrin against Amblyomma americanum (Lone Star tick) and Amblyomma maculatum (Gulf Coast tick) on dogs.
abstract: Amblyomma americanum (lone star tick) and Amblyomma maculatum (Gulf Coast tick) are important disease vectors for both dogs and humans. This article describes two studies conducted to evaluate the efficacy of a new topical spot-on ectoparasiticide containing dinotefuran, permethrin, and pyriproxyfen (Vectra 3D, Summit VetPharm) against A. maculatum and A. americanum in dogs. Dogs were treated on day 0 and infested on days -1, 7, 14, 21, and 28 with approximately 40 ticks each day. Live tick counts were determined 48 hours after infestation. Treatment with Vectra 3D resulted in a significant reduction in A. maculatum tick counts throughout the study period. For A. americanum, there was a significant reduction in tick counts from study day 9 onward. The results of this study indicate that Vectra 3D can be used as an effective part of an overall tick- and vector-borne disease control strategy on dogs when used monthly.
authors.affiliation: Summit VetPharm, Fort Lee, NJ 07024, USA.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Coyne
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004338:Drug Combinations; D005260:Female; D006146:Guanidines / Q000008:administration & dosage / Q000627:therapeutic use*; D007306:Insecticides / Q000008:administration & dosage / Q000627:therapeutic use; D026863:Ixodidae / Q000187:drug effects*; D008297:Male; D000073943:Neonicotinoids; D009574:Nitro Compounds / Q000008:administration & dosage / Q000627:therapeutic use*; D026023:Permethrin / Q000008:administration & dosage / Q000627:therapeutic use*; D011725:Pyridines / Q000008:administration & dosage / Q000627:therapeutic use*; D013984:Tick Infestations / Q000188:drug therapy / Q000662:veterinary*
chemical_list: D004338:Drug Combinations; D006146:Guanidines; D007306:Insecticides; D000073943:Neonicotinoids; D009574:Nitro Compounds; D011725:Pyridines; C465368:dinotefuran; C055613:pyriproxyfen; D026023:Permethrin