title: [Serological characteristics of hantaviruses from clinical specimens analyzed in 1998-2008 in the Department of Virology, Public Health Institute, Ostrava].
abstract: In 1998 - 2008, serum samples from 464 patients, predominantly residents of the Moravia-Silesian Region, were examined in the Department of Virology, Public Health Institute in Ostrava, using Enzyme-Linked ImmunoSorbent Assay (ELISA) for the detection of specific anti-hantavirus antibodies. Seropositivity was ascertained in 41 persons (8.8%). More patients tested seropositive against Hantaan virus (24, i.e. 58.5%) than against Puumala virus (13, i.e. 31.7%). Four persons were reactive against both antigens. Clinical symptoms corresponding to hantavirus infection were observed in 19 seropositive patients. Fifteen of them had antibodies reactive with Hantaan virus antigen (cross-reactive with anti-Dobrava virus), 3 patients had antibodies against Puumala virus and 1 patient had both types of antibodies. Clinical data on the other seropositive persons were lacking. The higher rate of Dobrava virus infections in the Moravian-Silesian Region seems to be associated, among others, with the geographic distribution of striped field mouse (Apodemus agrarius) which is the main reservoir of Dobrava virus in Central Europe.
authors.affiliation: Virologické oddelení, Národní referenTní laborator CR pro arboviry, Zdravotní ustav se sidlem v Ostrave. hana.zelena@zuova.cz
authors.forename: H
authors.initials: H
authors.lastname: Zelená
authors.forename: J
authors.initials: J
authors.lastname: Januska
mesh_terms: D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006476:Orthohantavirus / Q000276:immunology*; D018778:Hantavirus Infections / Q000175:diagnosis / Q000453:epidemiology*; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D029262:Puumala virus / Q000276:immunology; D016036:Seroepidemiologic Studies; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral