title: Surgery-assisted reproductive technology hybrid therapy: a reproductive procedure for an infertile woman of late reproductive age with multiple myomas.
abstract: OBJECTIVE
  To produce a successful pregnancy in a 38-year-old infertile patient with relapsed myoma using a technique we refer to as 'surgery-assisted reproductive technology (ART) hybrid therapy' because it combines ART for cryopreservation of in vitro fertilized eggs with reproductive surgery.
  
  
  METHODS
  A 38-year-old nulliparous woman who had undergone abdominal myomectomy and in whom magnetic resonance imaging showed multiple myomas was treated at our University-affiliated hospital and outpatient clinic. Blastocysts were cryopreserved during the preoperative period. Laparoscopic myomectomy was performed after preoperative treatment with a GnRH agonist. Ten months after the operation, the youngest cryopreserved blastocyst was transferred into the uterus and implanted successfully.
  
  
  RESULTS
  Treatment resulted in successful implantation and pregnancy. In January 2008, the course of pregnancy had been uneventful and the patient gave birth to a male infant weighing 2998 grams by cesarean section at 37 weeks of gestation.
  
  
  CONCLUSIONS
  We have treated eight patients using hybrid therapy with encouraging results, and we describe these cases herein briefly.
authors.affiliation: Department of Obstetrics and Gynaecology, Juntendo University School of Medicine, Tokyo, Japan. arthur@juntendo.ac.jp
authors.forename: Keiji
authors.initials: K
authors.lastname: Kuroda
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Takeuchi
authors.forename: Mari
authors.initials: M
authors.lastname: Kitade
authors.forename: Iwaho
authors.initials: I
authors.lastname: Kikuchi
authors.forename: Jun
authors.initials: J
authors.lastname: Kumakiri
authors.forename: Yuko
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kobori
authors.forename: Masako
authors.initials: M
authors.lastname: Kuroda
authors.forename: Kazuko
authors.initials: K
authors.lastname: Itagaki
authors.forename: Mai
authors.initials: M
authors.lastname: Machida
authors.forename: Satoru
authors.initials: S
authors.lastname: Takeda
mesh_terms: D000328:Adult; D015925:Cryopreservation; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007247:Infertility, Female / Q000628:therapy*; D007889:Leiomyoma / Q000601:surgery*; D008297:Male; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000601:surgery*; D027724:Reproductive Techniques, Assisted; D014594:Uterine Neoplasms / Q000601:surgery*