title: Dexpanthenol enhances skin barrier repair and reduces inflammation after sodium lauryl sulphate-induced irritation.
abstract: BACKGROUND
  Dexpanthenol-containing creams have been widely used for treatment of lesions (superficial wounds) of the skin and mucous membranes. Dexpanthenol is converted in tissues to pantothenic acid, a component of coenzyme A. Coenzyme A catalyses early steps in the synthesis of fatty acids and sphingolipids which are of crucial importance for stratum corneum lipid bilayers and cell membrane integrity.
  
  
  OBJECTIVE
  In the present study, the effects were examined of a dexpanthenol-containing cream on skin barrier repair, stratum corneum hydration, skin roughness, and inflammation after sodium lauryl sulphate (SLS)-induced irritation.
  
  
  METHODS
  Irritation was induced by application of SLS in patch test chambers. The dexpanthenol-contaming cream or the vehicle were applied twice daily and barrier repair, hydration, roughness, and inflammation of the skin were determined by using biophysical methods.
  
  
  RESULTS
  Significantly accelerated skin barrier repair was found in treatments with the dexpanthenol-containing cream (verum) compared with vehicle-treated (placebo) or untreated skin. Both verum and placebo showed an increase in stratum corneum hydration, but significantly more so with the dexpanthenol-containing cream. Both creams reduced skin roughness, but again the verum was superior. The dexpanthenol-containing cream significantly reduced skin redness as a sign of inflammation in contrast to the vehicle, which produced no effect.
  
  
  CONCLUSIONS
  Treatment with a dexpanthenol-containing cream showed significantly enhanced skin barrier repair and stratum corneum hydration, while reducing skin roughness and inflammation.
authors.affiliation: Department of Dermatology, University of Kieh Kiel, Germany. eproksch@dermatology.uni-kiel.de
authors.forename: E
authors.initials: E
authors.lastname: Proksch
authors.forename: H P
authors.initials: HP
authors.lastname: Nissen
mesh_terms: D000293:Adolescent; D000328:Adult; D017453:Dermatitis, Irritant / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010205:Pantothenic Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use; D012967:Sodium Dodecyl Sulfate; D013501:Surface-Active Agents; D014870:Water Loss, Insensible; D014945:Wound Healing; D055815:Young Adult
chemical_list: D013501:Surface-Active Agents; D010205:Pantothenic Acid; C007288:dexpanthenol; D012967:Sodium Dodecyl Sulfate