Albumin and lipid enriched albumin for the critically ill.
Albumin, the principal transporter of plasma fatty acids, binds to majority of the drugs ingested, traps oxygen radicals and has potent anti-oxidant actions. Albumin binds to its specific binding sites on vascular endothelial cells and thus, prevents endothelial apoptosis. Albumin regulates the enzyme pyruvate dehydrogenase, the flux of glucose and lactate in astrocytes, and enhances the formation of anti-inflammatory lipoxins, resolvins and protectins from docosahexaenoic acid (DHA) and other polyunsaturated fatty acids that, in turn, could limit ischemia-induced neuronal damage. This may explain the beneficial action of DHA-enriched albumin in stroke and other critical diseases.
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UND Life Sciences, 13800 Fairhill Road, #321, Shaker Heights, OH 44120, USA.
D000418:Albumins / Q000627:therapeutic use*; D016638:Critical Illness / Q000628:therapy*; D004281:Docosahexaenoic Acids / Q000627:therapeutic use*; D006801:Humans; D016779:Malaria, Cerebral / Q000188:drug therapy; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D018805:Sepsis / Q000188:drug therapy; D020521:Stroke / Q000188:drug therapy
D000418:Albumins; D018696:Neuroprotective Agents; D004281:Docosahexaenoic Acids