New tricks for old dogs: KCNQ expression and role in smooth muscle.
Ion channels encoded by the KCNQ gene family (K(v)7.1-7.5) are major determinants of neuronal membrane potential and the cardiac action potential. This key physiological role is highlighted by the existence of a number of hereditary disorders caused by mutations to KCNQ genes. Recently, KCNQ gene expression has been identified in vascular and non-vascular smooth muscles. In addition, experiments with an array of pharmacological modulators of KCNQ channels have supported a crucial role for these channels in regulating smooth muscle contractility. This article will provide an overview of present understanding in this nascent area of KCNQ research and will offer guidance as to future directions.
Greenwood
Iain A
IA
Division of Basic Medical Sciences, St George's, University of London, London, UK. i.greenwood@sgul.ac.uk
Ohya
Susumu
S
D002453:Cell Cycle; D049109:Cell Proliferation; D006801:Humans; D051656:KCNQ Potassium Channels / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*; D008564:Membrane Potentials; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D032389:Myocytes, Smooth Muscle / Q000187:drug effects / Q000378:metabolism*; D011188:Potassium / Q000378:metabolism*; D026902:Potassium Channel Blockers / Q000494:pharmacology; D011499:Protein Processing, Post-Translational; D015398:Signal Transduction / Q000187:drug effects
D051656:KCNQ Potassium Channels; D026902:Potassium Channel Blockers; D011188:Potassium