title: Intraoperative mitomycin C and corneal endothelium after pterygium surgery.
abstract: OBJECTIVE
  To determine the effect of mitomycin C (MMC) on the corneal endothelium after primary pterygium surgery.
  
  
  METHODS
  This prospective, interventional, nonrandomized, observer-masked study included 46 consecutive patients (51 eyes) with primary pterygium. The bare sclera technique with 1-minute application of 0.02% MMC intraoperatively was used in all cases. The follow-up period was 3 months. Preoperative and postoperative central corneal specular microscopy was performed. The endothelial cell density, coefficient of variation of cell size, and percentage of hexagonal cells were analyzed, and the corneal thickness was measured.
  
  
  RESULTS
  The mean endothelial cell densities preoperatively and 3 months postoperatively were 2382.35 +/- 342.07 cells per square millimeter (range, 1020-3129) and 2385.02 +/- 356.83 cells per square millimeter (range, 1001-3151), respectively (P = 0.96). The mean coefficients of variation of cell size preoperatively and 3 months postoperatively were 34.31 +/- 5.62 (range, 22-49) and 35.29 +/- 7.50 (range, 22-55), respectively (P = 0.17). The mean percentages of hexagonal cells values preoperatively and 3 months postoperatively were 52.98 +/- 7.32 (range, 32-71) and 51.61 +/- 8.98 (range, 32-67), respectively (P = 0.48). The mean pachymetry measurements preoperatively and 3 months postoperatively were 506.65 +/- 36.87 microm (range, 411-583) and 502.08 +/- 41.33 microm (range, 411-593), respectively (P = 0.99).
  
  
  CONCLUSIONS
  One intraoperative application of 0.02% MMC for 1 minute after primary pterygium surgery does not seem to cause substantial changes in the corneal endothelium at 3 months.
authors.affiliation: Department of Ophthalmology, University Hospital Principe de Asturias, Madrid, Spain. cinta.perezrico@gmail.com
authors.forename: Consuelo
authors.initials: C
authors.lastname: Pérez-Rico
authors.forename: Javier
authors.initials: J
authors.lastname: Benítez-Herreros
authors.forename: María Angeles
authors.initials: MA
authors.lastname: Montes-Mollón
authors.forename: Francisco
authors.initials: F
authors.lastname: Germain
authors.forename: María
authors.initials: M
authors.lastname: Castro-Rebollo
authors.forename: Yanira
authors.initials: Y
authors.lastname: Gómez-SanGil
authors.forename: Javier
authors.initials: J
authors.lastname: Paz-Moreno
authors.forename: Miguel Angel
authors.initials: MA
authors.lastname: Teus
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002452:Cell Count; D048430:Cell Shape; D048429:Cell Size; D004728:Endothelium, Corneal / Q000187:drug effects* / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007432:Intraoperative Period; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage*; D019384:Nucleic Acid Synthesis Inhibitors / Q000008:administration & dosage*; D011184:Postoperative Period; D011446:Prospective Studies; D011625:Pterygium / Q000473:pathology / Q000601:surgery*; D016037:Single-Blind Method; D013997:Time Factors
chemical_list: D019384:Nucleic Acid Synthesis Inhibitors; D016685:Mitomycin