Insulin secretagogue bioactivity of finger citron fruit (Citrus medica L. var. Sarcodactylis Hort, Rutaceae).
Finger citron [Citrus medica L. var. Sarcodactylis Hort, Rutaceae] (FC) fruits, widely cultivated in Japan, the southern provinces of China and Taiwan, are commonly used as functional vegetables and preserved as sweetmeats. Previously we identified the major compounds in essential oils (% in EO) of FC fruits to be d-limonene (51.24), gamma-terpenene (33.71), alpha-pinene (3.40), and beta-pinene (2.88). Documented evidence on its insulin secretion characteristics is still lacking. In parallel to compositional analysis, we performed in vivo the safety, hypoglycemic, and antidiabetic tests in Sprague-Dawley-SPF rats and Wistar DIO rats respectively. By kinetic analysis on the hypoglycemic patterns of the intraperitoneal glucose tolerance (IPGTT) and the insulin-glucose tolerance tests (IGTT), its insulin secretagogue effect was confirmed. In conclusion, FC fruits that concomitantly possess insulin secretagogue and slimming effects would be very beneficial to type 2 diabetes mellitus patients.
Peng
Chiung-Huei
CH
Research Institute of Biotechnology, Hungkuang University, Shalu County, Taichung Hsien, Taiwan. kenny.huangcn@msa.hinet.net
Ker
Yaw-Bee
YB
Weng
Ching-Feng
CF
Peng
Chiung-Chi
CC
Huang
Chien-Ning
CN
Lin
Li-Yun
LY
Peng
Robert Y
RY
D000818:Animals; D000081008:Bicyclic Monoterpenes; D001786:Blood Glucose / Q000032:analysis; D001643:Bridged Bicyclo Compounds / Q000032:analysis; D002957:Citrus / Q000737:chemistry*; D053138:Cyclohexenes / Q000032:analysis; D004032:Diet; D005638:Fruit / Q000737:chemistry*; D005951:Glucose Tolerance Test; D007004:Hypoglycemic Agents / Q000008:administration & dosage*; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D000077222:Limonene; D039821:Monoterpenes / Q000032:analysis; D009822:Oils, Volatile / Q000737:chemistry; D008517:Phytotherapy; D051381:Rats; D017207:Rats, Sprague-Dawley; D017208:Rats, Wistar; D013729:Terpenes / Q000032:analysis
D000081008:Bicyclic Monoterpenes; D001786:Blood Glucose; D001643:Bridged Bicyclo Compounds; D053138:Cyclohexenes; D007004:Hypoglycemic Agents; D007328:Insulin; D039821:Monoterpenes; D009822:Oils, Volatile; D013729:Terpenes; C010789:beta-pinene; D000077222:Limonene