title: GOLPH2 gene markers are not associated with Alzheimer's disease in a sample of the Spanish population.
abstract: GOLPH2 gene SNP variants Rs10868366 and Rs7019241 were reported to decrease the risk of Alzheimer's disease in a recent Whole Genome Association Study. We have investigated these genetic variants in 2470 individuals from Spain to conduct an independent replication study of the proposed SNP markers. We found no evidence of association between GOLPH2 markers and susceptibility to Alzheimer's disease in our series. We concluded that GOLPH2 gene does not contribute to risk of disease in this study sample.
authors.affiliation: Dementia Unit, University Hospital Virgen de la Arrixaca, Murcia, Spain.
authors.forename: Carmen
authors.initials: C
authors.lastname: Antúnez
authors.forename: Mercé
authors.initials: M
authors.lastname: Boada
authors.forename: Jesús
authors.initials: J
authors.lastname: López-Arrieta
authors.forename: Reposo
authors.initials: R
authors.lastname: Ramirez-Lorca
authors.forename: Isabel
authors.initials: I
authors.lastname: Hernández
authors.forename: Juan
authors.initials: J
authors.lastname: Marín
authors.forename: Pablo
authors.initials: P
authors.lastname: Martínez-Lage
authors.forename: Antonio
authors.initials: A
authors.lastname: González-Pérez
authors.forename: José
authors.initials: J
authors.lastname: Jorge Galan
authors.forename: Javier
authors.initials: J
authors.lastname: Gayán
authors.forename: Luis M
authors.initials: LM
authors.lastname: Real
authors.forename: Agustín
authors.initials: A
authors.lastname: Ruiz
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000235:genetics; D000544:Alzheimer Disease / Q000453:epidemiology / Q000235:genetics*; D001057:Apolipoproteins E / Q000378:metabolism; D002888:Chromosomes, Human, Pair 19; D005260:Female; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D015894:Genome, Human; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000235:genetics* / Q000378:metabolism*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D013030:Spain
chemical_list: D001057:Apolipoproteins E; C410824:GOLM1 protein, human; D005819:Genetic Markers; D008565:Membrane Proteins