New directions in clinical imaging of cortical dysplasias.
Neuroimaging is essential in the work-up of patients with intractable epilepsy. In pediatric patients with medically refractory epilepsy, cortical dysplasias account for a large percentage of the epileptogenic substrate. Unfortunately, these are also the most subtle lesions to identify. For this reason, there has been ongoing interest in utilizing new advanced magnetic resonance imaging (MRI) techniques to improve the ability to identify, diagnose, characterize, and delineate cortical dysplasias. Technologic gains such as multichannel coils (32 phased array and beyond) and higher field strengths (3T, 7T, and greater) coupled with newer imaging sequences such as arterial spin labeling (ASL), susceptibility weighted imaging (SWI) and diffusion tensor/spectrum imaging (DTI/DSI) are likely to increase yield. Improved MRI techniques coupled with a multimodality approach including magnetoencephalography (MEG), positron emission tomography (PET), and other techniques will increase sensitivity and specificity for identifying cortical dysplasias.
Madan
Neel
N
Division of Pediatric Radiology, Massachusetts General Hospital for Children, Boston, Massachusetts, USA.
Grant
P Ellen
PE
D000293:Adolescent; D000328:Adult; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D003936:Diagnosis, Computer-Assisted / Q000379:methods; D038524:Diffusion Magnetic Resonance Imaging; D004578:Electron Spin Resonance Spectroscopy; D004828:Epilepsies, Partial / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods* / Q000639:trends; D015225:Magnetoencephalography; D008297:Male; D054220:Malformations of Cortical Development / Q000145:classification / Q000175:diagnosis* / Q000601:surgery; D049268:Positron-Emission Tomography; D011247:Pregnancy; D011300:Preoperative Care; D011859:Radiography; D012680:Sensitivity and Specificity; D013226:Status Epilepticus / Q000175:diagnosis