title: YjhS (NanS) is required for Escherichia coli to grow on 9-O-acetylated N-acetylneuraminic acid.
abstract: The nanATEK-yhcH, yjhATS, and yjhBC operons in Escherichia coli are coregulated by environmental N-acetylneuraminic acid, the most prevalent sialic acid in nature. Here we show that YjhS (NanS) is a probable 9-O-acetyl N-acetylneuraminic acid esterase required for E. coli to grow on this alternative sialic acid, which is commonly found in mammalian host mucosal sites.
authors.affiliation: Laboratory of Sialobiology, Department of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61802, USA.
authors.forename: Susan M
authors.initials: SM
authors.lastname: Steenbergen
authors.forename: Jamie L
authors.initials: JL
authors.lastname: Jirik
authors.forename: Eric R
authors.initials: ER
authors.lastname: Vimr
mesh_terms: D004926:Escherichia coli / Q000235:genetics / Q000254:growth & development* / Q000378:metabolism*; D029968:Escherichia coli Proteins / Q000235:genetics / Q000502:physiology; D015964:Gene Expression Regulation, Bacterial / Q000235:genetics / Q000502:physiology; D019158:N-Acetylneuraminic Acid / Q000378:metabolism; D012794:Sialic Acids / Q000378:metabolism*
chemical_list: D029968:Escherichia coli Proteins; D012794:Sialic Acids; C025676:9-O-acetyl-N-acetylneuraminic acid; D019158:N-Acetylneuraminic Acid