Cascade synthesis of (E)-2-alkylidenecyclobutanols.
A facile, one-pot reaction cascade condenses 1,1,1-trichloroalkanes with alpha,beta-unsaturated ketones to unexpectedly furnish moderate to good yields of (E)-2-alkylidenecyclobutanols.
Falck
J R
JR
Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA. j.falck@utsouthwestern.edu
Bandyopadhyay
Anish
A
Puli
Narender
N
Kundu
Abhijit
A
Reddy
L Manmohan
LM
Barma
Deb K
DK
He
Anyu
A
Zhang
Hongming
H
Kashinath
Dhurke
D
Baati
Rachid
R
D003503:Cyclobutanes / Q000138:chemical synthesis* / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry; D013237:Stereoisomerism
D003503:Cyclobutanes; D007659:Ketones; C538814:cyclobutanol