title: Cisplatin-based chemotherapy: Add high-frequency audiometry in the regimen.
abstract: BACKGROUND
  Cisplatin-induced ototoxicity shows high interindividual variability and is often accompanied by transient or permanent tinnitus. It is not possible to identify the susceptible individuals before commencement of the treatment. We conducted a prospective, randomized and observational study in a tertiary care centre and evaluated the effects of different doses of cisplatin on hearing.
  
  
  METHODS
  Fifty-seven patients scheduled for cisplatin-based chemotherapy were included in the study. All patients were divided into three groups depending on the dose of cisplatin infused in 3 weeks.
  
  
  RESULTS
  The subjective hearing loss was found in seven patients, while six patients had tinnitus during the chemotherapy. The hearing loss was sensorineural, dose dependent, symmetrical, bilateral and irreversible. Higher frequencies were first to be affected in cisplatin chemotherapy.
  
  
  CONCLUSIONS
  As use of high-frequency audiometry is still limited in research work only, we need a strict protocol of adding high-frequency audiometry in the cisplatin-based chemotherapy regimen.
authors.affiliation: Departments of Otorhinolaryngology-Head and Neck Surgery, I G Medical College, Shimla, India.
authors.forename: R
authors.initials: R
authors.lastname: Arora
authors.forename: J S
authors.initials: JS
authors.lastname: Thakur
authors.forename: R K
authors.initials: RK
authors.lastname: Azad
authors.forename: N K
authors.initials: NK
authors.lastname: Mohindroo
authors.forename: D R
authors.initials: DR
authors.lastname: Sharma
authors.forename: R K
authors.initials: RK
authors.lastname: Seam
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001299:Audiometry; D002945:Cisplatin / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D005260:Female; D034381:Hearing Loss / Q000139:chemically induced*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000188:drug therapy; D014012:Tinnitus / Q000139:chemically induced*; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents; D002945:Cisplatin