[Anti-viral effects of Tankejing preparations against influenza virus A].
OBJECTIVE
To investigate the anti-viral effects of Tankejing preparations (including solutions, dry power inhalation and powder) against influenza virus A in vitro and the relationship between its anti-viral effect and preparations.


METHODS
The inhibitive effect of different drug-added ways of Tankejing extracts against human influenza virus A (H3N2) in vitro were assayed by crystallized purple staining method with ribavirin as positive reference drug. Then we compared the anti-viral actions of different kinds of Tankejing preparations. At last, we carried on serum pharmacodynamics to test and verify the effect.


RESULTS
Tankejing extracts had an effect on comprehensive inhibition and an inhibition on virus proliferation after adsorption. When the concentration was 0.062 g/mL, the inhibition rate of solution dry power inhalation and powder were 43.50%, 41.50% and 37.36%, respectively. The anti-viral effect of dry powder inhalation was better than power's in serum pharmacokinetis experiment.


CONCLUSIONS
Tankejing preparations display an action against human influenza virus A in vitro. Those preparation with better solubility have greater anti-viral effect.
Jiang
Yong-Nan
YN
Guangdong Food and Drug Vocational College, Guangzhou 510520, China. jiangyn@gdyzy.edu.cn
Mo
Hong-Ying
HY
D000818:Animals; D000998:Antiviral Agents / Q000008:administration & dosage / Q000494:pharmacology*; D002460:Cell Line; D004285:Dogs; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006801:Humans; D053122:Influenza A Virus, H3N2 Subtype / Q000187:drug effects* / Q000502:physiology; D008297:Male; D008826:Microbial Sensitivity Tests; D010946:Plants, Medicinal / Q000737:chemistry*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012254:Ribavirin / Q000008:administration & dosage / Q000494:pharmacology; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D012254:Ribavirin