A photoluminescent nanocrystal-based signaling protocol highly sensitive to nerve agents and highly toxic organophosphate pesticides.
A photoluminescent II-VI group semiconductor nanocrystal (NC)-based signaling platform composed of thioglycolic acid capped CdS NCs and acetylcholinesterase-acetylthiocholine enzyme catalytic reaction system was developed that was shown to be highly sensitive to nerve agents and toxic organophosphate pesticides with detection limits down to sub-nM levels. This new sensing protocol does not require troublesome conjugation of biomacromolecules onto the surface of NCs.
Yu
Tao
T
Department of Chemistry and The MOE Key Laboratory of Analytical Sciences, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, China.
Shen
Jiang-Shan
JS
Bai
Hai-Hong
HH
Guo
Lei
L
Tang
Ji-Jun
JJ
Jiang
Yun-Bao
YB
Xie
Jian-Wei
JW
D000042:Absorption; D000109:Acetylcholine / Q000737:chemistry / Q000378:metabolism; D000110:Acetylcholinesterase / Q000378:metabolism; D015374:Biosensing Techniques / Q000379:methods*; D019187:Cadmium Compounds / Q000737:chemistry; D008163:Luminescent Measurements; D053758:Nanoparticles / Q000737:chemistry*; D009420:Nervous System / Q000187:drug effects*; D010755:Organophosphates / Q000032:analysis* / Q000633:toxicity*; D010575:Pesticides / Q000032:analysis* / Q000633:toxicity*; D013440:Sulfides / Q000737:chemistry; D013864:Thioglycolates / Q000737:chemistry
D019187:Cadmium Compounds; D010755:Organophosphates; D010575:Pesticides; D013440:Sulfides; D013864:Thioglycolates; C034939:cadmium sulfide; D000110:Acetylcholinesterase; D000109:Acetylcholine