Redox regulation of DNA repair: implications for human health and cancer therapeutic development.
Redox reactions are known to regulate many important cellular processes. In this review, we focus on the role of redox regulation in DNA repair both in direct regulation of specific DNA repair proteins as well as indirect transcriptional regulation. A key player in the redox regulation of DNA repair is the base excision repair enzyme apurinic/apyrimidinic endonuclease 1 (APE1) in its role as a redox factor. APE1 is reduced by the general redox factor thioredoxin, and in turn reduces several important transcription factors that regulate expression of DNA repair proteins. Finally, we consider the potential for chemotherapeutic development through the modulation of APE1's redox activity and its impact on DNA repair.
Luo
Meihua
M
Department of Pediatrics, Herman B. Wells Center for Pediatric Research, Indiana University, Indiana, USA.
He
Hongzhen
H
Kelley
Mark R
MR
Georgiadis
Millie M
MM
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D004247:DNA / Q000235:genetics / Q000378:metabolism*; D004260:DNA Repair; D043603:DNA-(Apurinic or Apyrimidinic Site) Lyase / Q000378:metabolism; D006262:Health; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism*; D010084:Oxidation-Reduction
D004247:DNA; C085108:APEX1 protein, human; D043603:DNA-(Apurinic or Apyrimidinic Site) Lyase