High serum levels of growth factors are associated with good outcome in intracerebral hemorrhage.
In experimental models, growth factors (GFs) such as vascular endothelial growth factor (VEGF), Angiopoietin 1 (Ang-1), or granulocyte-colony stimulating factor (G-CSF) mediate brain recovery after intracerebral hemorrhage (ICH). Our aim was to study the association between serum levels of GF and clinical outcome in patients with ICH. A total of 95 patients with primary ICH (male, 66.3%; mean age, 67.8+/-9.8 years) were prospectively included in the study within 12 h from symptoms onset. The main outcome variable was good functional outcome at 3 months (modified Rankin scale < or =2). Median serum levels of GF at 72 h from stroke onset were significantly higher in patients with good outcome (n=39) compared with those with poor outcome (all P<0.0001). Serum levels of VEGF > or =330 pg/mL, G-CSF > or =413 pg/mL, and Ang-1 > or =35 ng/mL at 72 h were independently associated with good functional outcome (odds ratio (OR), 11.2; 95% confidence interval (CI): 2.9 to 43.0; OR, 19.6; 95% CI: 3.9 to 97.9; and OR, 14.7; 95% CI: 3.6 to 60.0, respectively), neurologic improvement (all P<0.0001) and reduced residual cavity at 3 months (all P<0.01). These results illustrate that high serum levels of GF are associated with good functional outcome and reduced lesion volume in ICH.
Sobrino
Tomás
T
Clinical Neuroscience Research Laboratory, Hospital Clínico Universitario, Santiago de Compostela, Spain.
Arias
Susana
S
Rodríguez-González
Raquel
R
Brea
David
D
Silva
Yolanda
Y
de la Ossa
Natalia Pérez
NP
Agulla
Jesús
J
Blanco
Miguel
M
Pumar
José M
JM
Serena
Joaquín
J
Dávalos
Antoni
A
Castillo
José
J
D000368:Aged; D002543:Cerebral Hemorrhage / Q000175:diagnosis* / Q000401:mortality; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies
D036341:Intercellular Signaling Peptides and Proteins