Benign metastasizing leiomyoma: report of 2 cases and review of the literature.
Benign metastasizing leiomyoma (BML) is a benign spindle cell lesion affecting women who have undergone hysterectomy for uterine leiomyomas in young adulthood, and subsequently present pulmonary metastases during the peri-menopausal period. We present 2 cases of BML in women with prior medical history of hysterectomy for multiple myomas. Both patients presented pulmonary metastases at 17 and 12 years after hysterectomy. The pulmonary nodules were totally excised in the both cases, and neither patient experienced complications or recurrences after 1 and 2 years of follow up, respectively. BML is a rare benign entity with a debated pathogenesis. We have developed different hypotheses about its pathogenesis, mechanisms of spread, histological characteristics and commonly employed treatment modalities.
Mlika
M
M
Department of Anatomopathology, Abderrahman Mami Hospital, Tunis, Tunisia. mlika.zorgati.mona@hotmail.com
Ayadi-Kaddour
A
A
Smati
B
B
Ismaïl
O
O
El Mezni
F
F
D005260:Female; D006801:Humans; D007044:Hysterectomy; D007889:Leiomyoma / Q000175:diagnosis* / Q000601:surgery; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000556:secondary* / Q000601:surgery; D008875:Middle Aged; D009362:Neoplasm Metastasis; D047648:Perimenopause; D016896:Treatment Outcome; D014594:Uterine Neoplasms / Q000473:pathology* / Q000601:surgery