title: Polymorphisms in the protein C inhibitor gene in in vitro fertilization failure.
abstract: The aim of this study was to determine whether total fertilization failure in human IVF can be partially explained by alterations in the gene that codes for protein C inhibitor. Forty-six men had IVF total fertilization failure and 51 controls with normal fertilization were screened for mutations in the protein C inhibitor gene by direct sequencing. The main finding was that in men involved in total fertilization failure, a heterozygous adenosine/guanine (A/G) base combination in position 1389 (rs2069990) (exon 6) in the protein C inhibitor gene was significantly more common compared with controls (10.9% vs. 0).
authors.affiliation: Reproductive Medicine Centre, Malmö University Hospital, Malmö, Sweden. mona.bungum@med.lu.se
authors.forename: Mona
authors.initials: M
authors.lastname: Bungum
authors.forename: Aleksander
authors.initials: A
authors.lastname: Giwercman
authors.forename: Leif
authors.initials: L
authors.lastname: Bungum
authors.forename: Peter
authors.initials: P
authors.lastname: Humaidan
authors.forename: Hamideh
authors.initials: H
authors.lastname: Rastkhani
authors.forename: Yvonne Lundberg
authors.initials: YL
authors.lastname: Giwercman
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005091:Exons; D005260:Female; D005307:Fertilization in Vitro; D005787:Gene Frequency; D006579:Heterozygote; D006801:Humans; D008297:Male; D010641:Phenotype; D010865:Pilot Projects; D020641:Polymorphism, Single Nucleotide; D018046:Protein C Inhibitor / Q000235:genetics*; D017211:Treatment Failure
chemical_list: D018046:Protein C Inhibitor; C534934:SERPINA5 protein, human