[NO-ergic system activation in the nucleus accumbens during presentation of contextual signals of danger].
In Spregue-Dawley rats by means of in vivo microdialysis combined with HPLC analysis, presentation of a chamber in which a conditioned fear response was previously acquired (tone(+) +footshock), resulted in an increase in extracellular level of citrulline (an NO co-product) in the medial nucleus accumbens. This increase was prevented by intraaccumbal infusion of 7-nitraindazole (0.5 mM), an NO synthase inhibitor. It was less than a rise in citrulline extracellular level induced by a combined presentation the chamber and the tone, but did not differ from citrulline changes occurring during the chamber presentation in the lateral nucleus accumbens. The data obtained indicate that conditioned signals of danger cause neuronal NO synthase activation in the medial and, probably, in the lateral nucleus accumbens which produces the rise in extracellular citrulline level and, likely, in NO formation in this brain area.
Saul'skaia
N B
NB
Fofonova
N V
NV
Sudorgina
P V
PV
D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D002956:Citrulline / Q000378:metabolism*; D005239:Fear / Q000502:physiology*; D007191:Indazoles / Q000494:pharmacology; D008297:Male; D017551:Microdialysis; D009569:Nitric Oxide / Q000378:metabolism*; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D052248:Nitric Oxide Synthase Type I; D009714:Nucleus Accumbens / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D007191:Indazoles; D002956:Citrulline; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase; D052248:Nitric Oxide Synthase Type I; C496322:Nos1 protein, rat; C080122:7-nitroindazole