Increasing incidence of zygomycosis (mucormycosis), France, 1997-2006.
We analyzed hospital records to provide a population-based estimate of zygomycosis incidence and trends over a 10-year period at a national level in France. Data showed an increasing incidence from 0.7/million in 1997 to 1.2/million in 2006 (p<0.001). We compared our data with those from the French Mycosis Study Group, a recently established voluntary network of French mycologists coordinated by the National Reference Center for Mycoses and Antifungals. We documented that incidence of zygomycosis increased, particularly in patients with hematologic malignancies or bone marrow transplants. The role of previous exposure to antifungal drugs lacking activity against zygomycetes could explain this increase but does not appear exclusive. Incidence also increased in the population of patients with diabetes mellitus. We conclude that observed trends reflect a genuine increase of zygomycosis cases in at-risk populations.
Infectious Diseases Department, Institut de Veille Sanitaire, Saint Maurice, France. d.bitar@invs.sante.fr
Dounia
D
Bitar
Dieter
D
Van Cauteren
Fanny
F
Lanternier
Eric
E
Dannaoui
Didier
D
Che
Francoise
F
Dromer
Jean Claude
JC
Desenclos
Olivier
O
Lortholary
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005602:France / Q000453:epidemiology; D019337:Hematologic Neoplasms / Q000150:complications* / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D009091:Mucormycosis / Q000453:epidemiology* / Q000382:microbiology / Q000401:mortality; D012307:Risk Factors; D055815:Young Adult; D020096:Zygomycosis / Q000453:epidemiology* / Q000382:microbiology / Q000401:mortality