Cytotoxic and antiplasmodial compounds from the roots of Strophioblachia fimbricalyx.
The known phenanthrenone trigonostemone (1), along with a new phenanthrenone, 9-O-demethyltrigonostemone (2), and two new phenanthropolones, 3,6,9-trimethoxyphenanthropolone (3) and 4,6,9-trimethoxyphenanthropolone (4), were isolated from the roots of Strophioblachia fimbricalyx. Compound 2 showed cytotoxicity against NCI-H187, KB, and MCF7 cancer cells with IC50 values of 0.8, 0.8, and 2.9 microg/mL, respectively, while 3 and 4 showed reduced cytotoxicity. Compounds 2 and 3 displayed antiplasmodial activity in vitro (IC50 values of 2.7 and 3.2 microg/mL, respectively) against Plasmodium falciparum (K1, resistant strain). In addition, the antioxidant activity of 1-4 toward DPPH radicals was determined, but only compound 2 showed any discernible activity.
Department of Chemistry, Faculty of Science, Mahasarakham University, Maha Sarakham 44150, Thailand. prapairat.s@msu.ac.th
Prapairat
P
Seephonkai
Aphidech
A
Sangdee
Pasakorn
P
Bunchalee
Stephen G
SG
Pyne
D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D004354:Drug Screening Assays, Antitumor; D019665:Euphorbiaceae / Q000737:chemistry*; D005260:Female; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy; D015394:Molecular Structure; D010616:Phenanthrenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects*; D013785:Thailand
C545132:9-O-demethyltrigonostemone; D000962:Antimalarials; D000972:Antineoplastic Agents, Phytogenic; D016166:Free Radical Scavengers; D010616:Phenanthrenes