Response of gram-positive bacteria to copper stress.
The Gram-positive bacteria Enterococcus hirae, Lactococcus lactis, and Bacillus subtilis have received wide attention in the study of copper homeostasis. Consequently, copper extrusion by ATPases, gene regulation by copper, and intracellular copper chaperoning are understood in some detail. This has provided profound insight into basic principles of how organisms handle copper. It also emerged that many bacterial species may not require copper for life, making copper homeostatic systems pure defense mechanisms. Structural work on copper homeostatic proteins has given insight into copper coordination and bonding and has started to give molecular insight into copper handling in biological systems. Finally, recent biochemical work has shed new light on the mechanism of copper toxicity, which may not primarily be mediated by reactive oxygen radicals.
Department of Clinical Pharmacology and Visceral Research, University of Berne, Switzerland. marc.solioz@ikp.unibe.ch
Marc
M
Solioz
Helge K
HK
Abicht
Mélanie
M
Mermod
Stefano
S
Mancini
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000595:Amino Acid Sequence; D000818:Animals; D001426:Bacterial Proteins / Q000737:chemistry / Q000378:metabolism; D003300:Copper / Q000378:metabolism / Q000633:toxicity*; D006094:Gram-Positive Bacteria / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism* / Q000502:physiology; D006706:Homeostasis / Q000187:drug effects; D006801:Humans; D008969:Molecular Sequence Data; D013312:Stress, Physiological / Q000187:drug effects*
D001426:Bacterial Proteins; D003300:Copper; D000251:Adenosine Triphosphatases