Antifungal activity of alpha-mangostin against Candida albicans.
This study was conducted to examine the activity of alpha-mangostin against Candida albicans, the most important microorganism implicated in oral candidiasis. Its activity was compared to Clotrimazole and Nystatin. Results showed that alpha-mangostin was effective against C. albicans, the minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) were 1,000 and 2,000 microg/ml, respectively. The C. albicans killing activity of alpha-mangostin was more effective than Clotrimazole and Nystatin. The cytotoxicity of alpha-mangostin was determined and it was found that alpha-mangostin at 4,000 microg/ml was not toxic to human gingival fibroblast for 480 min. The strong antifungal activity and low toxicity of alpha-mangostin make it a promising agent for treatment of oral candidiasis.
Oral Diagnosis Department, Faculty of Dentistry, Naresuan University, Phitsanulok, Thailand. Ruchadapornk@yahoo.com
Ruchadaporn
R
Kaomongkolgit
Kusuma
K
Jamdee
Niratcha
N
Chaisomboon
D000935:Antifungal Agents / Q000494:pharmacology* / Q000633:toxicity; D002176:Candida albicans / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D003022:Clotrimazole / Q000494:pharmacology; D005347:Fibroblasts / Q000187:drug effects; D005638:Fruit; D029762:Garcinia mangostana; D005881:Gingiva / Q000166:cytology / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D009761:Nystatin / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology* / Q000633:toxicity; D044004:Xanthones / Q000494:pharmacology* / Q000633:toxicity
D000935:Antifungal Agents; D010936:Plant Extracts; D044004:Xanthones; D009761:Nystatin; D003022:Clotrimazole; C021053:mangostin