Aminophosphine ligands R(2)P(CH(2))(n)NH(2) and ruthenium hydrogenation catalysts RuCl(2)(R(2)P(CH(2))(n)NH(2))(2).
The aminophosphine ligands R(2)P(CH(2))(2)NH(2) and R(2)P(CH(2))(3)NH(2) (R = Ph, (i)Pr, (t)Bu) were isolated in good to excellent yields from the reaction of LiPR(2) with Cl(CH(2))(2)N(TMS)(2) and Cl(CH(2))(3)N(TMS)(2), respectively, followed by hydrolysis. This approach allows fine tuning of the ligands' stereoelectronic properties through the variation of the substituents on the phosphine. The aminophosphine ligands were used to prepare the ruthenium complexes RuCl(2)(R(2)P(CH(2))(2)NH(2))(2) and RuCl(2)(R(2)P(CH(2))(3)NH(2))(2) by reacting a 2:1 mixture of the respective ligand and [RuCl(2)(cod)](n) in an appropriate solvent. The resulting complexes were found to be excellent catalysts for the hydrogenation of ketones and imines.
Kanata Chemical Technologies Inc., 101 College Street, Office 230, MaRS Centre, South Tower, Toronto, ON M5G 1L7, Canada.
Wenli
W
Jia
Xuanhua
X
Chen
Rongwei
R
Guo
Christine
C
Sui-Seng
Dino
D
Amoroso
Alan J
AJ
Lough
Kamaluddin
K
Abdur-Rashid