Local and regional adverse reactions to BCG-SSI vaccination: a 12-month cohort follow-up study.
In a 12-month cohort follow-up study of 2435 children vaccinated in 2007 by Statens Serum Institute BCG strain (BCG SSI, 17.8% had an adverse event (AE): erythema 12.4%, induration 12.2%, abscesses 2.5%, ulceration 0.9%, lymphadenitis 0.1%. The factors associated with a lower risk of AE were: age at vaccination <1 year compared to age >1 year (OR=0.35 [0.2-0.6] for age <28 days, 0.29 [0.2-0.42] for age 29 days to 2 months, and 0.53 [0.37-0.74] for age 3-11 months), a visible papule (OR=0.48 [0.36-0.63]), and a low vaccine dose (OR=0.42 [0.31-0.58]). AE to BCG SSI vaccination were frequent but rarely severe.
Dommergues
M A
MA
Infovac-France, F94100 Saint Maur des Fossés, France. madommergues@orange.fr
de La Rocque
F
F
Guy
C
C
Lécuyer
A
A
Jacquet
A
A
Guérin
N
N
Fagot
J P
JP
Boucherat
M
M
d'Athis
Ph
P
Cohen
R
R
D017677:Age Distribution; D001500:BCG Vaccine / Q000008:administration & dosage / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D005602:France; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011446:Prospective Studies; D012307:Risk Factors
D001500:BCG Vaccine