Source-based morphometry of gray matter volume in men with first-episode schizophrenia.
OBJECTIVE
There is a lot of variability between the results of studies reporting the pattern of gray matter volume changes in schizophrenia. Methodological issues may play an important role in this heterogeneity. The aim of the present study was to replicate the better performance of multivariate "source-based morphometry" (SBM) over the mass-univariate approach.


METHODS
Voxel-based morphometry of Jacobian-modulated gray matter volume images, using voxel and cluster level inference, and SBM were performed in a group of first-episode schizophrenia patients (N = 49) and healthy controls (N = 127).


RESULTS
Using SBM we were able to find a significant reduction of gray matter volume in fronto-temporo-cerebellar areas whereas no significant results were obtained using voxel-based morphometry.


CONCLUSIONS
Multivariate analysis of gray matter volume seems to be a suitable method for characterization of the pattern of changes at the beginning of the illness in schizophrenia subjects.
Kaspárek
Tomás
T
Department of Psychiatry, Masaryk University, Jihlavska 20, 625 00, Brno, the Czech Republic. tomas.kasparek@centrum.cz
Marecek
Radek
R
Schwarz
Daniel
D
Prikryl
Radovan
R
Vanícek
Jirí
J
Mikl
Michal
M
Cesková
Eva
E
D001921:Brain / Q000473:pathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D015999:Multivariate Analysis; D036421:Nerve Fibers, Unmyelinated / Q000473:pathology*; D009929:Organ Size; D012559:Schizophrenia / Q000473:pathology*; D055815:Young Adult