Regulated intramembrane proteolysis in the control of extracytoplasmic function sigma factors.
There is growing evidence that proteolytic degradation of membrane-spanning regulatory proteins such as anti-sigma factors is involved in a variety of important transmembrane signaling processes in bacteria. This mechanism of regulated intramembrane proteolysis (RIP) enables them to respond to extracellular signals and stresses. Here, we summarize current knowledge of RIP controlling extracytoplasmic function sigma factors.
Institute of Genetics, University of Bayreuth, Universitätsstrasse 30, D-95440 Bayreuth, Germany.
Janine
J
Heinrich
Thomas
T
Wiegert
D001412:Bacillus subtilis / Q000235:genetics / Q000378:metabolism; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D055162:Biocatalysis; D002462:Cell Membrane / Q000201:enzymology*; D015964:Gene Expression Regulation, Bacterial; D006090:Gram-Negative Bacteria / Q000235:genetics / Q000378:metabolism; D012808:Sigma Factor / Q000378:metabolism*; D013312:Stress, Physiological
D001426:Bacterial Proteins; C413458:SigW protein, Bacillus subtilis; D012808:Sigma Factor; C111259:sigE protein, Bacteria