Oocyte-specific genes: role in fertility and infertility.
Genetic determinations of oocyte and ovarian follicle growth are still not well understood. Genes specifically expressed on oocytes seem to play an important role in these processes. Oocyte-specific genes are also involved in ovulation and early embryogenesis processes. Studies on the identification and characterization of new oocyte-specific genes can help in our understanding of cardinal fertility and infertility mechanisms. They can also be candidate genes for reproductive disorders such as polycystic ovary syndrome, premature ovarian failure and infertility. Infertility is an important worldwide problem affecting around 15% of couples. Approximately 20% of infertility is referred as idiopathic infertility. Studies on these genes could improve the diagnostic and therapeutic procedures of human infertility.
Department of Gynecological Endocrinology, Poznan University of Medical Sciences, Poznan, Poland. blazejmeczekalski@yahoo.com
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Meczekalski
D000818:Animals; D005260:Female; D005298:Fertility / Q000235:genetics*; D005796:Genes / Q000502:physiology*; D006801:Humans; D007246:Infertility / Q000235:genetics*; D009865:Oocytes / Q000166:cytology / Q000378:metabolism* / Q000502:physiology; D009928:Organ Specificity / Q000235:genetics; D015044:Zona Pellucida / Q000378:metabolism