Acoustomotive optical coherence elastography for measuring material mechanical properties.
Acoustomotive optical coherence elastography (AM-OCE), a dynamic and internal excitation optical coherence elastography technique, is reported. Acoustic radiation force was used for internal mechanical excitation, and spectral-domain optical coherence tomography was used for detection. Mechanical properties of gelatin tissue phantoms were measured by AM-OCE and verified using rheometry results. Measured mechanical properties including shear moduli and shear damping parameters of the gelatin samples double when their polymer concentration increases from 3% to 4%. Spectral analysis was also performed on the acquired data, which improved the processing speed by a factor of 5 compared with a least-square fitting approach. Quantitative measurement, microscale resolution, and remote excitation are the main features of AM-OCE, which make the technique promising for measuring biomechanical properties.
Liang
Xing
X
Department of Electrical and Computer Engineering, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, 405 North Mathews, Urbana, Illinois 61801, USA.
Orescanin
Marko
M
Toohey
Kathleen S
KS
Insana
Michael F
MF
Boppart
Stephen A
SA
D000162:Acoustics; D000818:Animals; D001696:Biomechanical Phenomena; D001703:Biophysics / Q000379:methods; D054459:Elasticity Imaging Techniques / Q000379:methods; D004867:Equipment Design; D005780:Gelatin / Q000737:chemistry; D006801:Humans; D055095:Optics and Photonics; D019047:Phantoms, Imaging; D011108:Polymers / Q000737:chemistry; D012212:Rheology / Q000379:methods; D013314:Stress, Mechanical; D041623:Tomography, Optical Coherence / Q000379:methods*
D011108:Polymers; D005780:Gelatin