Immunophenotypic features of acute myeloid leukemia with inv(3)(q21q26.2)/t(3;3)(q21;q26.2).
Immunophenotypic identification of myeloid specific antigens is an important diagnostic tool in the management of patients with acute myeloid leukemia (AML). These antigens allow determination of cell of origin and degree of differentiation of leukemia blasts. AML with inv(3)(q21q26.2)/t(3;3)(q21;q26.2) is a relatively rare subtype of AML. The immunophenotypic characteristics of inv(3) AML patients are somewhat limited. We identified 14 new cases of hematological disorders with increased myeloid blasts carrying inv(3)(q21q26.2)/t(3;3)(q21;q26.2). Also, we identified another 13 cases previously published in the literature, where the immunophenotype of inv(3)(q21q26.2) was documented. As a group, patients with AML with inv(3)(q21q26.2) had high levels of early myeloid (CD13, CD33, CD117 and MPO) and uncommitted markers (CD34, HLA-DR and CD56) and a high rate of monosomy 7 in addition to the inv(3)(q21q26.2). Differential karyotype and expression of certain antigens were noted in patients with de novo AML with inv(3)(q21q26.2) vs. those with inv(3)(q21q26.2)-containing blasts.
Department of Medicine, Division of Hematology, Stanford University, Stanford, CA, USA. bruno.medeiros@stanford.edu
Bruno C
BC
Medeiros
Holbrook E
HE
Kohrt
Daniel A
DA
Arber
Charles D
CD
Bangs
Athena M
AM
Cherry
Ravindra
R
Majeti
Karen E
KE
Kogel
Catherine A
CA
Azar
Samit
S
Patel
Ash A
AA
Alizadeh
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD / Q000096:biosynthesis; D002469:Cell Separation; D007446:Chromosome Inversion; D005260:Female; D005434:Flow Cytometry; D006684:HLA-DR Antigens / Q000235:genetics; D006801:Humans; D016130:Immunophenotyping; D053208:Kaplan-Meier Estimate; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000145:classification / Q000235:genetics* / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D015514:Oncogene Proteins, Fusion / Q000235:genetics; D011379:Prognosis; D055815:Young Adult
D015703:Antigens, CD; D006684:HLA-DR Antigens; D015514:Oncogene Proteins, Fusion; C481798:RPN1-EVI1 fusion protein, human