Lactone derivatives from the marine-derived fungus Penicillium sp. PSU-F44.
Two new fungal metabolites, penicipyrone (1), and penicilactone (2), were isolated from the marine-derived fungus Penicillium sp. PSU-F44 along with three known macrolides, (+)-brefeldin A (3), (+)-brefeldin C (4), and 7-oxobrefeldin A (5). Their antimicrobial activities against methicillin-resistant Staphylococcus aureus SK1 and Microsporum gypseum SH-MU-4 were examined.
Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand.
Kongkiat
K
Trisuwan
Vatcharin
V
Rukachaisirikul
Yaowapa
Y
Sukpondma
Souwalak
S
Phongpaichit
Sita
S
Preedanon
Jariya
J
Sakayaroj
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D007783:Lactones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D010407:Penicillium / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D007783:Lactones; C545750:penicilactone; C545749:penicipyrone