The efficacy of monepantel, an amino-acetonitrile derivative, against gastrointestinal nematodes of sheep in three countries of southern Latin America.
The efficacy of the novel anthelmintic, monepantel (an amino-acetonitrile derivative), was investigated in sheep naturally infected with gastrointestinal nematodes in five studies in Argentina, Brazil, and Uruguay. Monepantel, administered at 2.5 mg/kg liveweight, was highly effective (>99.7%) against Haemonchus contortus, Teladorsagia (Ostertagia) circumcincta, Trichostrongylus axei, Trichostrongylus colubriformis, Cooperia curticei, Cooperia mcmasteri, Cooperia oncophora, Cooperia pectinata, Cooperia punctata, and Nematodirus spathiger, including strains resistant to the older broad-spectrum anthelmintics. Efficacy against C. mcmasteri, C. pectinata, and C. punctata is documented for the first time. The treatment with monepantel was well tolerated by the sheep.
Novartis Animal Health Chile, Las Condes, Santiago, Chile.
Miguel
M
Bustamante
Pedro E
PE
Steffan
Jorge
J
Bonino Morlán
Flavio
F
Echevarria
César A
CA
Fiel
Herculano
H
Cardozo
Daniel
D
Castells
Barry C
BC
Hosking
D000607:Aminoacetonitrile / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000818:Animals; D000969:Antinematodal Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D001118:Argentina; D001938:Brazil; D005243:Feces / Q000469:parasitology; D005260:Female; D005767:Gastrointestinal Diseases / Q000188:drug therapy / Q000662:veterinary*; D008297:Male; D009349:Nematode Infections / Q000188:drug therapy / Q000662:veterinary*; D010270:Parasite Egg Count; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy* / Q000469:parasitology; D016896:Treatment Outcome; D014583:Uruguay
D000969:Antinematodal Agents; D000607:Aminoacetonitrile; C533978:monepantel