Cholesterol worships a new idol.
The growing worldwide epidemic of cardiovascular disease suggests that new therapeutic strategies are needed to complement statins in the lowering of cholesterol levels. In a recent paper in Science, Tontonoz and colleagues have identified Idol as a protein that can control cholesterol levels by regulating the stability of the low-density lipoprotein receptor; inhibiting the activity of Idol could provide novel approaches for the treatment of cardiovascular disease.
Center for Molecular Design and Department of Pharmacology, University of Virginia Health System, Charlottesville, VA 22908, USA. igs4c@virginia.edu
Ira G
IG
Schulman
D000818:Animals; D002784:Cholesterol / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D000071518:Liver X Receptors; D051379:Mice; D057093:Orphan Nuclear Receptors / Q000378:metabolism; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism*
D000071518:Liver X Receptors; D057093:Orphan Nuclear Receptors; D002784:Cholesterol; D044767:Ubiquitin-Protein Ligases