Gene polymorphism of IFNG +874 T/A and TLR4 +896 A/G and recurrent infections and wheezing in toddlers with history of bronchiolitis.
Cytokine and TLR4 polymorphisms and their association with the infection history of 129 children hospitalized for bronchiolitis during the first 6 months of life were analyzed. The carriers of IFNG +874 T/A allele A had fewer infections and use of inhaled corticosteroids and the carriers of TLR4+896 A/G allele G were more likely to need tympanostomy than noncarriers.
Paediatric Research Centre, University of Tampere and Seinäjoki Central Hospital, Tampere, Finland.
Kirsi
K
Nuolivirta
Mikko
M
Hurme
Anne
A
Halkosalo
Petri
P
Koponen
Matti
M
Korppi
Timo
T
Vesikari
Merja
M
Helminen
D001988:Bronchiolitis / Q000235:genetics*; D002675:Child, Preschool; D005260:Female; D020022:Genetic Predisposition to Disease; D006579:Heterozygote; D006801:Humans; D007223:Infant; D007371:Interferon-gamma / Q000235:genetics*; D016753:Interleukin-10 / Q000235:genetics*; D020382:Interleukin-18 / Q000235:genetics; D008297:Male; D012135:Respiratory Sounds / Q000235:genetics*; D051197:Toll-Like Receptor 4 / Q000235:genetics*
C508609:IL10 protein, human; D020382:Interleukin-18; C495345:TLR4 protein, human; D051197:Toll-Like Receptor 4; D016753:Interleukin-10; D007371:Interferon-gamma