Antituberculosis activity of the molecular libraries screening center network library.
There is an urgent need for the discovery and development of new antitubercular agents that target novel biochemical pathways and treat drug-resistant forms of the disease. One approach to addressing this need is through high-throughput screening of drug-like small molecule libraries against the whole bacterium in order to identify a variety of new, active scaffolds that will stimulate additional biological research and drug discovery. Through the Molecular Libraries Screening Center Network, the NIAID Tuberculosis Antimicrobial Acquisition and Coordinating Facility tested a 215,110-compound library against Mycobacterium tuberculosis strain H37Rv. A medicinal chemistry survey of the results from the screening campaign is reported herein.
Maddry
Joseph A
JA
Southern Research Institute, 2000 Ninth Avenue South, Birmingham, AL 35205, USA. maddry@southernresearch.org
Ananthan
Subramaniam
S
Goldman
Robert C
RC
Hobrath
Judith V
JV
Kwong
Cecil D
CD
Maddox
Clinton
C
Rasmussen
Lynn
L
Reynolds
Robert C
RC
Secrist
John A
JA
Sosa
Melinda I
MI
White
E Lucile
EL
Zhang
Wei
W
D000995:Antitubercular Agents / Q000494:pharmacology*; D016000:Cluster Analysis; D055808:Drug Discovery; D004353:Drug Evaluation, Preclinical; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D012106:Research; D054852:Small Molecule Libraries; D014376:Tuberculosis / Q000188:drug therapy* / Q000235:genetics
D000995:Antitubercular Agents; D054852:Small Molecule Libraries