Outcomes at age 2 years of infants < 28 weeks' gestational age born in Victoria in 2005.
OBJECTIVE
To determine the survival rates and neurosensory outcomes of infants born at gestational age 22-27 weeks in the state of Victoria in 2005 and compare theses data with those for similar infants born in the 1990s.


METHODS
This was a population-based study of all extremely preterm (22-27 weeks' gestational age) live births in Victoria in 2005 free of lethal anomalies and randomly selected term controls. Survival and quality-adjusted survival rates at age 2 years were determined relative to the controls, and results were compared with regional extremely preterm cohorts born in 1991-92 and 1997.


RESULTS
Of 270 very preterm live births in 2005, 172 (63.7%) survived to 2 years, not significantly different from the survival rate of 69.6% for those born in 1997. Rates of severe developmental delay and severe disability were lower than in the very preterm survivors born in 1997. Quality-adjusted survival rates in the extremely preterm cohorts rose from 42.1% in 1991-92 to 55.1% in 1997, but did not increase in 2005 (53.4%).


CONCLUSIONS
Survival rates for infants born at 22-27 weeks' gestational age have not increased since the late 1990s, but the neurosensory outcome in survivors has improved.
Doyle
Lex W
LW
Newborn Services, Royal Women's Hospital, Melbourne, Australia. lwd@unimelb.edu.au
Roberts
Gehan
G
Anderson
Peter J
PJ
D002547:Cerebral Palsy / Q000453:epidemiology*; D002657:Child Development; D002675:Child, Preschool; D002658:Developmental Disabilities / Q000453:epidemiology*; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000401:mortality*; D008297:Male; D011379:Prognosis; D015996:Survival Rate; D014739:Victoria / Q000453:epidemiology