Individual Variability in Brain Activity: A Nuisance or an Opportunity?
Functional imaging research has been heavily influenced by results based on population-level inference. However, group average results may belie the unique patterns of activity present in the individual that ordinarily are considered random noise. Recent advances in the evolution of MRI hardware have led to significant improvements in the stability and reproducibility of blood oxygen level dependent (BOLD) measurements. These enhancements provide a unique opportunity for closer examination of individual patterns of brain activity. Three objectives can be accomplished by considering brain scans at the individual level; (1) Mapping functional anatomy at a fine grained analysis; (2) Determining if an individual scan is normative with respect to a reference population; and (3) Understanding the sources of intersubject variability in brain activity. In this review, we detail these objectives, briefly discuss their histories and present recent trends in the analyses of individual variability. Finally, we emphasize the unique opportunities and challenges for understanding individual differences through international collaboration among Pacific Rim investigators.
Laboratory of Neuro Imaging, Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90025 USA , Fax (310) 206-5518  jvanhorn@loni.ucla.edu.
John Darrell
JD
Van Horn
Scott T
ST
Grafton
Michael B
MB
Miller