[Ezrin and inducible nitric oxide synthase in malignant proliferation of salivary gland pleomorphic adenoma].
OBJECTIVE
Ezrin and inducible nitric oxide synthase (iNOS) may play an important role in regulating tumor proliferation, invasion, and metastasis. This study was to investigate the expression of Ezrin and iNOS and their correlation to malignant proliferation of salivary gland pleomorphic adenoma (PA).


METHODS
Expressions of Ezrin, iNOS and nuclear Ki-67 antigen were detected by immunohistochemistry in common type (n=40), active type (n=25) and malignant (n=11) pleomorphic adenoma.


RESULTS
Expressions of Ezrin, iNOS in common type, active type and malignant pleomorphic adenoma were gradually increased (P<0.05). There was a significant positive correlation between the expression of Ezrin and iNOS (P<0.05). Ki-67 proliferation index (Ki-67 PI) was increased with the increasing of Ezrin and iNOS expressions (P<0.05).


CONCLUSIONS
Overexpression of Ezrin and iNOS may promote proliferation and malignant transformation of salivary gland pleomorphic adenoma.
Department of Oral and Maxillofacial Surgery, Second Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510120, P. R. China.
You-Yuan
YY
Wang
Wei-Liang
WL
Chen
Wei-Xiong
WX
Zhang
Zhi-Bao
ZB
Bai
Zhi-Quan
ZQ
Huang
Jin-Song
JS
Li
D008949:Adenoma, Pleomorphic / Q000378:metabolism* / Q000473:pathology; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002471:Cell Transformation, Neoplastic / Q000378:metabolism*; D003598:Cytoskeletal Proteins / Q000378:metabolism*; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D052247:Nitric Oxide Synthase Type II / Q000378:metabolism*; D012468:Salivary Gland Neoplasms / Q000378:metabolism* / Q000473:pathology; D055815:Young Adult; D000099149:Ezrin
D003598:Cytoskeletal Proteins; D019394:Ki-67 Antigen; D052247:Nitric Oxide Synthase Type II; D000099149:Ezrin; C496319:NOS2 protein, human