Focal adhesion kinase as potential target for cancer therapy (Review).
Focal adhesion kinase (FAK) is a 125-kDa non-receptor and non-membrane protein tyrosine. FAK can function with integrins and growth factor receptors to promote cell survival dependent kinase activity and nuclear FAK promotes cell proliferation and survival through FERM (FAK, ezrin, radixin, moesin) domain-enhanced p53 degradation independent kinase activity. Many previous studies have indicated that FAK plays a critical role in the biological processes of normal and cancer cells and FAK has been proposed as a potential target in cancer therapy. Small molecule inhibitors (PF-573,228; PF-562,271 and NVP-226) for use as potential cancer therapies have been developed. However, the detailed mechanism of the role for FAK in tumor cell generation and progression remain unclear, so future work is needed to explore these issues. New inhibitors that can be effectively inhibit the function of FAK still need to be explored due to the low specificity, and resistance.
Hao
Huifang
H
Department of Gastroenterological Surgery, Transplant and Surgical Oncology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8558, Japan.
Naomoto
Yoshio
Y
Bao
Xiaohong
X
Watanabe
Nobuyuki
N
Sakurama
Kazufumi
K
Noma
Kazuhiro
K
Motoki
Takayuki
T
Tomono
Yasuko
Y
Fukazawa
Takuya
T
Shirakawa
Yasuhiro
Y
Yamatsuji
Tomoki
T
Matsuoka
Junji
J
Wang
Z G
ZG
Takaoka
Munenori
M
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D051416:Focal Adhesion Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*
D000970:Antineoplastic Agents; D051416:Focal Adhesion Protein-Tyrosine Kinases