Luminex-based virtual crossmatching facilitates combined third-time cardiac and de novo renal transplantation in a sensitized patient with sustained antibody-mediated cardiac allograft rejection.
Allosensitization represents a major obstacle to successful re-transplantation since circulating antibodies can elicit antibody-mediated rejection episodes with subsequent graft failure. Since sensitization is primarily considered a contraindication to transplantation the duration for patients waiting for a suitable donor organ to become available is considerably prolonged. Herein, we report on the successful application of a Luminex-based virtual crossmatch approach to facilitate combined third-time cardiac and de novo renal transplantation in a sensitized patient with sustained antibody-mediated cardiac allograft rejection.
Department of Cardiac Surgery, University Hospital Grosshadern, Ludwig-Maximilians-University, Marchioninistrasse, Munich, Germany.
Marcus-André
MA
Deutsch
Teresa
T
Kauke
Sebastian
S
Sadoni
Sieglinde
S
Kofler
Daniel
D
Schmauss
Amir K
AK
Bigdeli
Max
M
Weiss
Bruno
B
Reichart
Ingo
I
Kaczmarek
D002648:Child; D017023:Coronary Angiography; D004797:Enzyme-Linked Immunosorbent Assay; D006084:Graft Rejection / Q000276:immunology*; D016027:Heart Transplantation / Q000276:immunology*; D006650:Histocompatibility Testing / Q000379:methods*; D006801:Humans; D007118:Immunoassay / Q000379:methods*; D016030:Kidney Transplantation / Q000276:immunology*; D008297:Male; D012086:Reoperation