No way out for tumor cells.
In this issue of Cancer Cell, Huang et al. report that preventing exit from mitosis provides a very efficient strategy for killing cells. Although this is not an unexpected finding, it nevertheless provides a novel conceptual framework for augmenting the antimitotic strategies currently under development for fighting cancer.
Division of Translational Medicine, Wadsworth Center, New York State Department of Health, Albany, NY 12201, USA. rieder@wadsworth.org
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D050256:Antimitotic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D064199:Cdc20 Proteins; D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism*; D019926:Cyclin B / Q000378:metabolism; D056744:Cyclin B1; D019008:Drug Resistance, Neoplasm; D004791:Enzyme Inhibitors / Q000494:pharmacology; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D016547:Kinesins / Q000037:antagonists & inhibitors / Q000378:metabolism; D051336:Mitochondrial Membranes / Q000187:drug effects / Q000378:metabolism; D008938:Mitosis / Q000187:drug effects*; D009369:Neoplasms / Q000201:enzymology / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D010539:Permeability; D011499:Protein Processing, Post-Translational; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism; D034622:RNA Interference; D008941:Spindle Apparatus / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D013997:Time Factors
D050256:Antimitotic Agents; C534699:CCNB1 protein, human; D064199:Cdc20 Proteins; D018797:Cell Cycle Proteins; D019926:Cyclin B; D056744:Cyclin B1; D004791:Enzyme Inhibitors; D019253:Proto-Oncogene Proteins c-bcl-2; C577488:CDC20 protein, human; D016547:Kinesins