[239Pu and chromosomal aberrations in human peripheral blood lymphocytes].
The genome status in somatic cells was assessed using the chromosomal aberration (CA) test in peripheral blood lymphocytes from 194 plutonium workers exposed to occupational radiation mainly from low-transportable compounds of airborne 230Pu. Pu body burden at the time of cytogenetic study varied from values close to the method sensitivity to values multiply exceeding the permissible level. Standard (routine) methods of peripheral blood lymphocytes cultivation were applied. Chromatid- and chromosomal-type structural changes were estimated. Aberrations were estimated per 100 examined metaphase cells. The quantitative relationship between the CA frequency and Pu body burden and the absorbed dose to the lung was found. Mathematical processing of results was carried out based on the phenomenological model. The results were shown as theoretical and experimental curves. The threshold of the CA yield was 0.43 +/- 0.03 kBq (Pu body burden) and 6.12 +/- 1.20 cGy (absorbed dose to the lung).
N D
ND
Okladnikova
S V
SV
Osovets
T I
TI
Kudriavtseva
D000328:Adult; D000336:Aerosols; D000368:Aged; D001822:Body Burden; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays / Q000009:adverse effects; D006801:Humans; D008168:Lung / Q000528:radiation effects; D008214:Lymphocytes / Q000528:radiation effects*; D008875:Middle Aged; D008957:Models, Genetic; D016273:Occupational Exposure / Q000009:adverse effects*; D011005:Plutonium / Q000009:adverse effects*
D000336:Aerosols; D011005:Plutonium