Isolated inflammatory myopathy with rimmed vacuoles presenting with dropped head.
We describe an unusual case of inflammatory myopathy with rimmed vacuoles associated with dropped head syndrome. Muscle biopsy in our patient revealed variations in fiber size with fiber necrosis and regeneration, accompanied by many rimmed vacuoles and areas of endomysial cell infiltration. Electron microscopy demonstrated autophagic vacuoles and tubulofilamentous inclusions. This myopathy can cause dropped head syndrome in a subgroup of patients.
Department of Neurology, Nara Medical University, Kashihara, Nara, Japan. hk55@naramed-u.ac.jp
Hiroshi
H
Kataoka
Kazuma
K
Sugie
Mari
M
Terashima
Munehisa
M
Koizumi
Hirosei
H
Horikawa
Ichizo
I
Nishino
Ikuya
I
Nonaka
Satoshi
S
Ueno
D000368:Aged; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006257:Head; D006801:Humans; D008279:Magnetic Resonance Imaging; D018482:Muscle, Skeletal / Q000473:pathology / Q000648:ultrastructure; D009220:Myositis / Q000150:complications* / Q000188:drug therapy / Q000473:pathology*; D009336:Necrosis / Q000473:pathology; D011187:Posture; D011241:Prednisone / Q000627:therapeutic use; D012038:Regeneration; D013577:Syndrome; D016896:Treatment Outcome; D014617:Vacuoles / Q000473:pathology* / Q000648:ultrastructure
D000893:Anti-Inflammatory Agents; D011241:Prednisone