Bioactive flavones and biflavones from Selaginella moellendorffii Hieron.
Three new flavones named 5-carboxymethyl-4',7-dihydroxyflavone (1), its ethyl ester (2) and butyl ester (3) were isolated from the herb Selaginella moellendorffii Hieron., together with ten known compounds. Their structures were elucidated on the basis of spectroscopic and chemical analysis. Selected compounds were evaluated for their anti-HBV and cytotoxic activity. Among them, compounds 2 and 3 displayed inhibitory activity in vitro on hepatitis B virus (HBV) surface antigen (HBsAg) secretion of the Hep G2.2.15 cell line with IC(50) values of 0.17 mg/ml and 0.46 mg/ml, and on HBV e antigen (HBeAg) secretion with IC(50) values of 0.42 mg/ml and 0.42 mg/ml, respectively. Compounds 7, 8, 10 and 12 exhibited selective cytotoxicity against the three human cancer cell lines tested.
Cao
Yuan
Y
Department of Chinese Materia Medica Analysis, China Pharmaceutical University, No.24, Tongjia Lane, Nanjing 210009, PR China.
Tan
Nin-Hua
NH
Chen
Ji-Jun
JJ
Zeng
Guang-Zhi
GZ
Ma
Yun-Bao
YB
Wu
Yong-Ping
YP
Yan
He
H
Yang
Jie
J
Lu
Lai-Feng
LF
Wang
Qiang
Q
D000954:Antigens, Surface; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D000998:Antiviral Agents / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D045744:Cell Line, Tumor; D047309:Flavones / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D056945:Hep G2 Cells; D006509:Hepatitis B / Q000188:drug therapy; D006515:Hepatitis B virus / Q000187:drug effects*; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy*; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D032503:Selaginellaceae / Q000737:chemistry*
C552460:5-carboxybutylester-4',7-dihydroxyflavone; C552459:5-carboxyethylester-4',7-dihydroxyflavone; C552458:5-carboxymethyl-4',7-dihydroxyflavone; D000954:Antigens, Surface; D000972:Antineoplastic Agents, Phytogenic; D000998:Antiviral Agents; D047309:Flavones; D010936:Plant Extracts