[Investigating genotype of HCV distribution among residents in a "blood donation" village in Hebei Province].
OBJECTIVE
To investigate genotype of HCV infection among residents in a rural village, Hebei Province.


METHODS
Blood samples of the 520 residents were collected, and C/E1 of HCV genome of the 483 samples were obtained by RT-PCR amplifying, and the gene sequences were analyzed and the polygenetic tree were drawn by the software Mega 4.0.


RESULTS
In 483 subjects, HCV-RNA positive objectives are 70, positive prevalence is 14.5%, genotyping for all the samples successfully, including genotypes 1b and 2a, which are 36 (51.4%), 34 (48.6%) respectively.


CONCLUSIONS
HCV RNA positive rate is 14.5%, which is higher than general people. Subtypes 1b and 2a seemed to be the dominant genotypes of HCV in Zhao county area of Hebei Province.
Huang
Chang-Hong
CH
Hebei Medical University, Shijiazhuang 050017, China.
Zhou
Ji-Kun
JK
Liu
Li
L
Jiang
Rong-Men
RM
Cao
Yan-Qiang
YQ
Mu
Zhen-Yun
ZY
Zhang
Yong
Y
D000293:Adolescent; D000328:Adult; D001782:Blood Donors; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D005260:Female; D005838:Genotype; D016174:Hepacivirus / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D006526:Hepatitis C / Q000453:epidemiology* / Q000821:virology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D010802:Phylogeny; D055815:Young Adult