Association between recurrent miscarriages and organochlorine pesticide levels.
OBJECTIVE
Recurrent miscarriage (RM) is a challenging medical problem because of its unknown pathogenesis and etiology in most of the cases. Recent studies suggest the role of persistent environmental pollutants such as organochlorine pesticides (OCPs) in the etiology of RM. The present study was conducted to investigate possible associations of OCPs in the pathogenesis of RM.


METHODS
Blood OCP levels were analyzed in women with RM (cases) and women with normal full term delivery with live birth (controls) by using a gas chromatograph equipped with an electron capture detector.


RESULTS
A statistically significant association (p=0.01) was observed between blood gamma-HCH levels and women with recurrent miscarriages.


CONCLUSIONS
This study suggests that high blood levels of gamma-HCH may be associated with risk of RM.
Environmental Biochemistry and Immunology Laboratory, Department of Biochemistry, University College of Medical Sciences & GTB Hospital, University of Delhi, Dilshad Garden, Delhi 110 095, India.
Rahul
R
Pathak
Md
M
Mustafa
Rafat S
RS
Ahmed
A K
AK
Tripathi
Kiran
K
Guleria
B D
BD
Banerjee
D000026:Abortion, Habitual / Q000097:blood* / Q000209:etiology; D000328:Adult; D000818:Animals; D002849:Chromatography, Gas / Q000295:instrumentation / Q000379:methods; D004785:Environmental Pollutants / Q000097:blood*; D005260:Female; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000097:blood*; D007194:India; D010575:Pesticides / Q000097:blood*; D011247:Pregnancy; D055815:Young Adult
D004785:Environmental Pollutants; D006843:Hydrocarbons, Chlorinated; D010575:Pesticides