Carnitine conjugate of nipecotic acid: a new example of dual prodrug.
As a novel example of improved entry of poorly delivered drugs into the brain by means of nutrient conjugates, L-carnitine was conjugated to nipecotic acid and the capacity to antagonize PTZ-induced convulsions of this novel entity was evaluated.
Department of Pharmaceutical Sciences, University of Ferrara, Via Fossato di Mortara 17-19, I-44100 Ferrara, Italy.
Carmela
C
Napolitano
Martina
M
Scaglianti
Emanuela
E
Scalambra
Stefano
S
Manfredini
Luca
L
Ferraro
Sarah
S
Beggiato
Silvia
S
Vertuani
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002331:Carnitine / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D007274:Injections, Intraperitoneal; D051379:Mice; D009557:Nipecotic Acids / Q000008:administration & dosage / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D011355:Prodrugs / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D012640:Seizures / Q000188:drug therapy
D009557:Nipecotic Acids; D011355:Prodrugs; C030278:nipecotic acid; D002331:Carnitine