Rapid simultaneous acquisition of T1 and T2 mapping images using multishot double spin-echo EPI and automated variations of TR and TE (ms-DSEPI-T12).
A rapid method of simultaneous T(1) and T(2) measurement is presented which uses a segmented echo-planar readout with varying repetition times (TR) and echo times (TE). This method is useful in T(1) mapping for analysis of dynamic contrast enhanced MRI (DCE-MRI), where T(1) can be used to estimate contrast agent concentration. In the application of this method to dynamic imaging, the equilibrium magnetization is measured on pre-contrast images and incorporated into post-contrast T(1) calculations for improved accuracy. Simultaneous T(2) measurement allows correction of T(2) effects in the T(1) map which may occur at high contrast agent concentrations, and is performed without significant imaging time penalty. Phantom and in vivo results show the usefulness of this technique for analysis of contrast enhancement kinetics. Accurate rapid contrast agent concentration measurement may be useful for analyzing the distribution and kinetics of contrast agents or labeled pharmaceuticals.
Department of Physics, University of Utah, Salt Lake City, UT, USA.
Xin
X
Liu
Yi
Y
Feng
Zheng-Rong
ZR
Lu
Glen
G
Morrell
Eun-Kee
EK
Jeong
D000465:Algorithms; D000818:Animals; D045744:Cell Line, Tumor; D003287:Contrast Media / Q000378:metabolism*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods; D051379:Mice; D008819:Mice, Nude; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology; D019047:Phantoms, Imaging; D015203:Reproducibility of Results
D003287:Contrast Media