Elevated first-trimester uric acid concentrations are associated with the development of gestational diabetes.
OBJECTIVE
We sought to demonstrate that elevated first-trimester uric acid is associated with development of gestational diabetes mellitus (GDM).


METHODS
Uric acid was measured in 1570 plasma samples collected at mean gestational age of 8.9 +/- 2.5 weeks. The primary outcome was GDM, diagnosed by 3-hour glucose tolerance test using Carpenter and Coustan criteria or by a 1-hour value of > or =200 mg/dL. Logistic regression was performed, adjusting for relevant covariates.


RESULTS
Almost half (46.6%) of the women with GDM had first-trimester uric acid concentrations in the highest quartile (>3.57-8.30 mg/dL). Women with uric acid in the highest quartile had a 3.25-fold increased risk (95% confidence interval, 1.35-7.83) of developing GDM after adjustment for body mass index and age. This effect was concentration dependent as risk increased with increasing uric acid quartiles (P = .003).


CONCLUSIONS
First-trimester hyperuricemia is associated with an increased risk of developing GDM, independent of body mass index.
Department of Obstetrics, Gynecology and Reproductive Services, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. laughonsk@mail.nih.gov
S Katherine
SK
Laughon
Janet
J
Catov
Traci
T
Provins
James M
JM
Roberts
Robin E
RE
Gandley
D015992:Body Mass Index; D016640:Diabetes, Gestational / Q000097:blood* / Q000453:epidemiology; D005260:Female; D006801:Humans; D033461:Hyperuricemia / Q000453:epidemiology; D007333:Insulin Resistance / Q000502:physiology; D016015:Logistic Models; D011247:Pregnancy; D011261:Pregnancy Trimester, First / Q000097:blood*; D012372:ROC Curve; D014527:Uric Acid / Q000097:blood*
D014527:Uric Acid