Polymorphism of IL-8 in 251 allele and gastric cancer susceptibility: a meta-analysis.
BACKGROUND
The relationship of gastric cancer to the presence of interleukin-8 (IL-8) 251 T/A has been reported with conflicting results.


OBJECTIVE
To further explore the association of IL-8 251 allele polymorphism with gastric cancer susceptibility.


METHODS
We performed an extensive search of relevant studies and carried out a meta-analysis, including ten studies with 2,195 gastric cancer cases and 3,505 controls, to obtain a more precise estimate.


RESULTS
The combined results based on all studies showed that the IL-8 251 allele AA genotype was a risk factor for gastric cancer [AA versus TT: odds ratio (OR) = 1.363, 95% confidence interval (CI): 1.199-1.527]. In subgroup analysis, a clear effect of AA in IL-8 251 allele was shown in Asians (AA versus TT: OR = 1.593, 95% CI: 1.013-2.173) but not in Caucasians or Mexicans. When stratified by Lauren classification, we found that the IL-8 251 allele TA and AA polymorphism was significantly associated with the diffuse type of gastric cancer (TA versus TT: OR = 1.448, 95% CI: 1.177-1.720; AA versus TT: OR = 1.586, 95% CI: 1.128-2.044). The IL-8 251 AA genotype was found to be a risk factor for cardiac gastric cancer (AA versus TT: OR = 1.840, 95% CI: 1.112-2.568) but not for noncardiac gastric cancer.


CONCLUSIONS
This meta-analysis suggested that IL-8 251 allele A>T polymorphism might be a risk factor for gastric cancer.
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, People's Republic of China. jwang2006@126.com
Jing
J
Wang
Hai-Feng
HF
Pan
Yun-Tao
YT
Hu
Yu
Y
Zhu
Qian
Q
He
D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D020022:Genetic Predisposition to Disease / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D016209:Interleukin-8 / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic; D011379:Prognosis; D020133:Reverse Transcriptase Polymerase Chain Reaction; D018570:Risk Assessment; D013274:Stomach Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D016019:Survival Analysis
D016209:Interleukin-8