Learning how to read ADP-ribosylation.
ADP-ribosylation is a posttranslational modification that is emerging as a broadly used mechanism to regulate the functions of proteins and their interactions. Recent findings by three groups (Ahel et al., 2009; Gottschalk et al., 2009; Timinszky et al., 2009) establish that proteins with macrodomains bind poly-ADP-ribose to mediate the cellular response to DNA damage.
Kleine
Henning
H
Institute of Biochemistry and Molecular Biology, Medical School, RWTH Aachen University, Pauwelsstrasse 30, Aachen, Germany.
Lüscher
Bernhard
B
D036002:ADP Ribose Transferases / Q000378:metabolism; D000818:Animals; D004260:DNA Repair; D006801:Humans; D011064:Poly Adenosine Diphosphate Ribose / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D011506:Proteins / Q000378:metabolism*
D011506:Proteins; D011064:Poly Adenosine Diphosphate Ribose; D036002:ADP Ribose Transferases