Study on toxicity of danshensu in beagle dogs after 3-month continuous intravenous infusion.
Danshensu (3-(3,4-dihydroxyphenyl) lactic acid), a natural phenolic acid, is isolated from root of Salvia miltiorrhiza, and is widely used as a traditional Chinese medicine for treatment of various cardiovascular diseases. In the present study, toxicity of danshensu was evaluated in male and female dogs after 3-month continuous intravenous infusion. Beagle dogs were treated with danshensu at doses of 17, 50, and 150 mg/kg/day, and observed for 90 days followed by recovery periods. Measurements included clinical observations, body weight, food consumption, temperature, electro-cardiography (EGC), hematology, blood chemistry, urinalysis, gross necropsy, organ weight, and histopathology. No significant adverse effects on these parameters were observed. The only treatment-related finding was a hard knot at injection site observed in the 150 mg/kg group after 2-3 weeks continuous administration, and returned to normal after 3-4 days withdrawal. From these results, it might be concluded that danshensu did not produce any significant cumulative toxicity at the doses administered, as reflected by the various parameters investigated.
Li
Guisheng
G
School of Pharmacy, Yantai University, Yantai, Shandong Province, PR China.
Gao
Yonglin
Y
Li
Shenjun
S
Li
Chunmei
C
Zhu
Xiaoyin
X
Li
Min
M
Liu
Zhifeng
Z
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage* / Q000737:chemistry / Q000633:toxicity*; D005260:Female; D006801:Humans; D007773:Lactates / Q000008:administration & dosage* / Q000737:chemistry / Q000633:toxicity*; D007928:Lethal Dose 50; D008297:Male; D008516:Medicine, Chinese Traditional; D015394:Molecular Structure; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
D004365:Drugs, Chinese Herbal; D007773:Lactates; C035055:3,4-dihydroxyphenyllactic acid