Acute hepatitis E infection associated with a false-positive serology against Epstein-Barr virus.
Hepatitis E virus is a major cause of acute viral hepatitis. The diagnosis of acute viral hepatitis E is based essentially on antibodies and hepatitis E virus RNA. We describe herein a case of acute hepatitis E associated with a false-positive serology for Epstein-Barr virus (EBV). This case report suggests that anti-viral capsid antigen IgM must be interpreted with caution in acute E hepatitis. When positive, EBV RNA polymerase chain reaction can be useful as a false positivity of anti-viral capsid antigen IgM and can be misinterpreted as an acute infection. EBV false positivity was probably related to polyclonal stimulation of the immune system, favoured by hepatitis E.
AP-HP, Service d'Hépato-Gastroentérologie, Hôpital Antoine Béclère, Clamart, France.
Mariana
M
Ghinoiu
Sylvie
S
Naveau
Nadège
N
Barri-Ova
Juliette
J
Thaury
Liliane
L
Grangeot-Keros
Gabriel
G
Perlemuter
D000208:Acute Disease; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D003937:Diagnosis, Differential; D020031:Epstein-Barr Virus Infections / Q000175:diagnosis*; D005189:False Positive Reactions; D016751:Hepatitis E / Q000175:diagnosis*; D016752:Hepatitis E virus / Q000276:immunology; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D014195:Travel
D000914:Antibodies, Viral; D007075:Immunoglobulin M