The relationship between brachial ankle pulse wave velocity and complement 1 inhibitor.
Complement 1 (C1) inhibitor is an acute phase protein with anti-inflammatory properties. The aim of the present study was to elucidate the relationship between brachial ankle pulse wave velocity (baPWV), the parameter of arterial stiffness, and C1 inhibitor. One hundred subjects were randomly enrolled in this study. Data about baPWV, age, gender, hypertension, smoking, and body mass index (BMI) were measured. Blood tests for total cholesterol, low density lipoprotein, high density lipoprotein, triglycerides, hemoglobin A1c, erythrocyte sedimentation rate, C-reactive protein, complement 3, and C1 inhibitor were performed. Based on the Pearson correlation, the C1 inhibitor showed a positive relation to the baPWV (P<0.001). Multiple regression analysis revealed the significant predictors of baPWV were not only the conventional risk factors of arteriosclerosis and/or atherosclerosis, such as age (P<0.001), gender (P<0.001), hypertension (P<0.001), and BMI (P=0.006), but also the acute phase protein, C1 inhibitor (P=0.025). In conclusion, C1 inhibitor is associated with arterial stiffness through its association with increased inflammation.
Chae
Yong Min
YM
Department of Surgery, Masan Samsung Hospital, Sungkyunkwan University School of Medicine, Masan, Korea.
Park
Jong Kwon
JK
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000842:Ankle / Q000098:blood supply; D055109:Ankle Brachial Index; D001783:Blood Flow Velocity / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology; D015992:Body Mass Index; D001916:Brachial Artery / Q000502:physiology*; D050718:Complement C1 Inhibitor Protein / Q000378:metabolism*; D004548:Elasticity; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012044:Regression Analysis; D012307:Risk Factors; D012737:Sex Factors
D050718:Complement C1 Inhibitor Protein