Acromegaly associated with gangliocytoma.
BACKGROUND
Acromegaly secondary to growth hormone-releasing hormone (GHRH) excess is rare.
We report two patients with acromegaly who were diagnosed with sellar gangliocytomas that were immunopositive for GHRH. Tumour tissue persisted after debulking surgery and in the second case this was associated with persistent growth hormone hypersecretion, successfully suppressed by a somatostatin analogue.


CONCLUSIONS
The development of functional pituitary adenomas in association with sellar gangliocytomas is poorly understood. We present a brief discussion of the possible aetiology of these unusual pituitary tumours.
Academic Department of Endocrinology, Beaumont Hospital, Dublin 9, Ireland. rachelcrowley@hotmail.com
R K
RK
Crowley
Y
Y
Al-Derazi
K
K
Lynch
D
D
Rawluk
C J
CJ
Thompson
M
M
Farrell
A
A
Agha
D000172:Acromegaly / Q000209:etiology*; D000236:Adenoma / Q000150:complications* / Q000000981:diagnostic imaging / Q000378:metabolism; D005729:Ganglioneuroma / Q000150:complications* / Q000000981:diagnostic imaging / Q000378:metabolism; D013007:Growth Hormone-Releasing Hormone / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging / Q000378:metabolism; D011859:Radiography
D013007:Growth Hormone-Releasing Hormone