Reward value of intromissions and morphine in male rats evaluated by conditioned place preference.
The present experiment was designed to determine if intromissions alone could induce a reward state as evaluated by conditioned place preference (CPP). We also compared the rewarding properties of one ejaculation and a morphine injection. We evaluated if intromissions alone could induce CPP in males with one or three ejaculations as previous sexual experience. Different groups of males were allowed to display 5, 10, and 15 intromissions or an ejaculation with a sexually receptive female before being placed in the originally non-preferred compartment of a CPP cage. On alternate days they were placed in the preferred compartment. The groups that displayed 5 or 10 intromissions did not modify their original preference, regardless of whether they had experienced 1 or 3 ejaculations before the conditioning procedure. The groups that had experienced 1 ejaculations that were allowed to display 15 intromissions or one ejaculation modified their original preference indicating the induction of a reward state. These results suggest that male rats displaying sexual behavior require a minimum amount of stimulation, 15 intromissions or an ejaculation, in order for sex to be sufficiently rewarding to induce CPP. In a separate experiment we evaluated if a morphine injection (1mg/kg) has the same reward value that one ejaculation in male rats has. Two groups of sexually active males were used, in one group ejaculation was paired with the initially non-preferred compartment and morphine administration was paired with the initially preferred compartment. In the other group morphine injection was paired with the non-preferred compartment and ejaculation with the preferred compartment. None of the groups changed their originally preferred compartment suggesting that morphine and one ejaculation have the same reward value in male rats.
Instituto de Neurobiología, Universidad Nacional Autónoma de México, Querétaro, México.
Francisco J
FJ
Camacho
Wendy
W
Portillo
Olaguer
O
Quintero-Enríquez
Raúl G
RG
Paredes
D000704:Analysis of Variance; D000818:Animals; D003216:Conditioning, Operant / Q000187:drug effects*; D004542:Ejaculation / Q000187:drug effects*; D008297:Male; D009020:Morphine / Q000008:administration & dosage / Q000494:pharmacology*; D009294:Narcotics / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000187:drug effects; D012201:Reward; D012726:Sexual Behavior, Animal / Q000187:drug effects / Q000502:physiology*; D013997:Time Factors
D009294:Narcotics; D009020:Morphine