The many facets of the matricelluar protein periostin during cardiac development, remodeling, and pathophysiology.
Periostin is a member of a growing family of matricellular proteins, defined by their ability to interact with components of the extracellular milieu, and with receptors at the cell surface. Through these interactions, periostin has been shown to play a crucial role as a profibrogenic molecule during tissue morphogenesis. Tissues destined to become fibrous structures are dependent on cooperative interactions between periostin and its binding partners, whereas in its absence, these structures either totally or partially fail to become mature fibrous entities. Within the heart, fibrogenic differentiation is required for normal tissue maturation, remodeling and function, as well as in response to a pathological myocardial insult. In this review, aspects related to the function of periostin during cardiac morphogenesis, remodeling and pathology are summarized.
Department of Cell Biology and Anatomy, Medical University of South Carolina, BSB Suite 601, 173 Ashley Avenue, Charleston, SC 29425 USA.
Russell A
RA
Norris
Ricardo
R
Moreno-Rodriguez
Stanley
S
Hoffman
Roger R
RR
Markwald