Innate immune cells cast an eye on DNA.
The threonine phosphatase eyes absent (EYA) has been identified as a novel regulator of innate immune responses to cytosolic nucleic acids and undigested DNA from apoptotic cells. EYA regulates responses of yet unidentified DNA sensors and enhances interferon-beta and CXCL10 transcription.
Sander
Leif E
LE
Department of Medicine, Immunology Institute, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA.
Blander
J Magarian
JM
D000818:Animals; D004247:DNA / Q000276:immunology*; D004331:Drosophila melanogaster / Q000378:metabolism; D007113:Immunity, Innate / Q000276:immunology*; D051379:Mice; D008954:Models, Biological; D015534:Trans-Activators / Q000378:metabolism*
C527542:Eya4 protein, mouse; D015534:Trans-Activators; D004247:DNA