Proteases in bacterial pathogenesis.
Bacterial pathogens rely on proteolysis for protein quality control under adverse conditions experienced in the host, as well as for the timely degradation of central virulence regulators. We have focused on the contribution of the conserved Lon, Clp, HtrA and FtsH proteases to pathogenesis and have highlighted common biological processes for which their activities are important for virulence.
Ingmer
Hanne
H
Department of Veterinary Disease Biology, University of Copenhagen, Faculty of Life Sciences Stigbøjlen 4, University of Copenhagen, Frederiksberg C. DK1870, Denmark. hi@life.ku.dk
Brøndsted
Lone
L
D049069:ATP-Dependent Proteases / Q000378:metabolism; D001419:Bacteria / Q000201:enzymology / Q000472:pathogenicity*; D001426:Bacterial Proteins / Q000378:metabolism*; D049071:Endopeptidase Clp / Q000378:metabolism; D006360:Heat-Shock Proteins / Q000378:metabolism; D010447:Peptide Hydrolases / Q000378:metabolism*; D033903:Periplasmic Proteins / Q000378:metabolism; D049070:Protease La / Q000378:metabolism; D053038:Quorum Sensing; D012697:Serine Endopeptidases / Q000378:metabolism; D013312:Stress, Physiological; D037521:Virulence Factors / Q000378:metabolism*
D001426:Bacterial Proteins; D006360:Heat-Shock Proteins; D033903:Periplasmic Proteins; D037521:Virulence Factors; D010447:Peptide Hydrolases; D049069:ATP-Dependent Proteases; C061682:DegP protease; D012697:Serine Endopeptidases; D049070:Protease La; D049071:Endopeptidase Clp