2-Hydroxydiplopterol, a new cytotoxic pentacyclic triterpenoid from the halotolerant fungus Aspergillus variecolor B-17.
A new hopane type pentacyclic triterpenoid, 2-hydroxydiplopterol (1) has been isolated from the metabolites produced by the halotolerant fungal strain Aspergillus variecolor B-17. The structure of 1 was determined by spectroscopic methods and single crystal X-Ray diffraction analysis. 2-Hydroxydiplopterol (1) exhibited cytotoxicity against K562 cells with an IC50 value of 22 microM.
Wang
Wen-Liang
WL
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
Liu
Pei-Pei
PP
Zhang
Ya-Peng
YP
Li
Jing
J
Tao
Hong-Wen
HW
Gu
Qian-Qun
QQ
Zhu
Wei-Ming
WM
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001230:Aspergillus / Q000378:metabolism*; D018360:Crystallography, X-Ray; D006801:Humans; D020014:K562 Cells; D007941:Leukemia P388 / Q000188:drug therapy; D051379:Mice; D053978:Pentacyclic Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
D000970:Antineoplastic Agents; D053978:Pentacyclic Triterpenes