[Molecular markers in salivary gland tumors: their use in diagnostic and prognostic workup].
The molecular genetic background of salivary gland neoplasms has not been characterized in detail to date. However, interesting target genes which could be used as prognostic and diagnostic molecular biomarkers have already been identified, e.g. CRTC1-MAML2 in mucoepidermoid carcinoma, or PLAG1 and HMGA2 in pleomorphic adenoma. In particular, CRTC1-MAML2 has shown strong diagnostic and prognostic potential in recent years. One of the major advantages of molecular tumor markers is that valid results are obtained on minute cell and/or tissue samples. Due to high-throughput techniques like comparative genome hybridization (CGH), micro- or gene profiling array detection of new marker genes can be expected in the future. This is also true for the most frequent malignant salivary gland tumors after the mucoepidermoid carcinoma, i.e. adenoid cystic carcinomas and acinic cell carcinomas.
Zentrum für Humangenetik, Universität Bremen, Bremen.
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Stenman
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Bullerdiek
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Löning
D008949:Adenoma, Pleomorphic / Q000175:diagnosis / Q000235:genetics / Q000473:pathology; D014408:Biomarkers, Tumor / Q000235:genetics*; D018267:Carcinoma, Acinar Cell; D003528:Carcinoma, Adenoid Cystic; D018277:Carcinoma, Mucoepidermoid / Q000175:diagnosis / Q000235:genetics / Q000473:pathology; D002869:Chromosome Aberrations; D055028:Comparative Genomic Hybridization; D004252:DNA Mutational Analysis; D004268:DNA-Binding Proteins; D050939:Gene Fusion; D025743:HMGA2 Protein; D006801:Humans; D009363:Neoplasm Proteins / Q000235:genetics*; D009687:Nuclear Proteins; D011379:Prognosis; D040081:Protein Array Analysis; D012468:Salivary Gland Neoplasms / Q000175:diagnosis* / Q000235:genetics* / Q000473:pathology*; D012469:Salivary Glands / Q000473:pathology; D015534:Trans-Activators; D014157:Transcription Factors
D014408:Biomarkers, Tumor; C500984:CRTC1 protein, human; D004268:DNA-Binding Proteins; D025743:HMGA2 Protein; C471297:MAML2 protein, human; D009363:Neoplasm Proteins; D009687:Nuclear Proteins; C104382:PLAG1 protein, human; D015534:Trans-Activators; D014157:Transcription Factors