Ultraviolet radiation and immunosuppression.
Ultraviolet (UV) radiation is a complete carcinogen. The effects of UV radiation are mediated via direct damage to cellular DNA in the skin and suppression of image surveillance mechanisms. In the context of organ transplantation, addiction of drugs which suppress the immune system add greatly to the carcinogenicity of UV radiation. This review considers the mechanisms of such effects.
Murphy
G M
GM
Department of Dermatology, Beaumont & Mater Misericordiae Hospital, Dublin, Ireland. gmurphyoffice@eircom.net
D000818:Animals; D017209:Apoptosis / Q000276:immunology* / Q000528:radiation effects; D004249:DNA Damage / Q000276:immunology* / Q000528:radiation effects; D006801:Humans; D007165:Immunosuppression Therapy; D051379:Mice; D008810:Mice, Inbred C57BL; D009381:Neoplasms, Radiation-Induced / Q000276:immunology*; D012867:Skin / Q000276:immunology* / Q000528:radiation effects; D014466:Ultraviolet Rays / Q000009:adverse effects*