Xanthepinone, an antimicrobial polyketide from a soil fungus closely related to Phoma medicaginis.
The isolation, biological characterization, and structure elucidation of xanthepinone, a novel antifungal metabolite isolated from the broth of submerged cultures of a soil fungus, are described. Xanthepinone inhibits the conidial germination of Magnaporthe grisea (2 microg/mL), Phytophthora infestans (5 microg/mL), and Botrytis cinerea (10 microg/mL) while showing only weak antibacterial activity; cytotoxicity was not observed up to 50 microg/mL. Molecular taxonomy revealed that the producing strain is close to species in the genus Phoma as well as to uncultured soil fungi and endophytes.
Liermann
Johannes C
JC
Institut für Organische Chemie, Universität Hamburg, Martin-Luther-King-Platz 6, D-20146 Hamburg, Germany.
Kolshorn
Heinz
H
Opatz
Till
T
Thines
Eckhard
E
Anke
Heidrun
H
D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001203:Ascomycota / Q000737:chemistry*; D020171:Botrytis / Q000187:drug effects; D018360:Crystallography, X-Ray; D006367:HeLa Cells; D006575:Heterocyclic Compounds, 3-Ring / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D020082:Magnaporthe / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D055750:Phytophthora infestans / Q000187:drug effects
D000935:Antifungal Agents; D006575:Heterocyclic Compounds, 3-Ring; C545125:xanthepinone