Highly efficient chemoselective N-acylation with water microreaction system in the absence of catalyst.
A high-speed, highly efficient chemoselective N-acylation by anhydride was achieved in the absence of catalyst for exothermic (DeltaH>0) and endothermic (DeltaH<0) acylation of various amines and anilines with the microreaction system of ambient water (micro-onH2O) and subcritical water (micro-subH2O), where the desired N-acylated products are chemoselectively obtained with high yield(s) and excellent selectivity (>95%).
National Institute of Advanced Industrial Science and Technology (AIST), Research Center for Compact Chemical Process, 4-2-1 Nigatake, Miyagino-ku, Sendai, 9838551, Japan. masahiro-satou@aist.go.jp
Masahiro
M
Sato
Keiichiro
K
Matsushima
Hajime
H
Kawanami
Maya
M
Chatterjee
Toshiro
T
Yokoyama
Yutaka
Y
Ikuhsima
Toshishige Maro
TM
Suzuki