Role of MSH6 and PMS2 in the dna mismatch repair process and carcinogenesis.
In comparison with the mismatch repair genes MLH1 and MSH2, the genes MSH6 and PMS2 are relatively understudied with respect to cancer risk. However, some recent large studies of data combined from several sources, using analytic methods that appropriately condition on the varying methods of ascertainment, are producing reasonably precise estimates, which can be used for risk estimation in patients. To identify modifiers for risk in such carriers, a goal for epidemiologists to improve the health of carriers, such collaborative studies need to continue and expand to include additional mutation carriers in which lifestyle factors and DNA samples are available for analysis.
Jenkins
Mark A
MA
Centre for MEGA Epidemiology, School of Population Health, The University of Melbourne, Victoria 3010, Australia. m.jenkins@unimelb.edu.au
D000251:Adenosine Triphosphatases / Q000502:physiology*; D053843:DNA Mismatch Repair; D045643:DNA Repair Enzymes / Q000502:physiology*; D004268:DNA-Binding Proteins / Q000502:physiology*; D006801:Humans; D000070976:Mismatch Repair Endonuclease PMS2; D009369:Neoplasms / Q000235:genetics*
D004268:DNA-Binding Proteins; C094443:G-T mismatch-binding protein; D000251:Adenosine Triphosphatases; C094934:PMS2 protein, human; D000070976:Mismatch Repair Endonuclease PMS2; D045643:DNA Repair Enzymes