Summon SUMO to wrestle with inflammation.
In this issue of Molecular Cell, Lee et al. (2009) report that SUMOylation of nuclear receptors LXRalpha and LXRbeta plays a critical role in the transrepression of IFN-gamma-induced STAT1-dependent inflammatory responses in brain astrocytes.
Division of Hematology-Oncology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA. bliu@ucla.edu
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D000818:Animals; D001253:Astrocytes / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000235:genetics / Q000378:metabolism* / Q000517:prevention & control; D018836:Inflammation Mediators / Q000378:metabolism*; D007371:Interferon-gamma / Q000378:metabolism*; D008024:Ligands; D000071518:Liver X Receptors; D057093:Orphan Nuclear Receptors; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D051381:Rats; D020239:Receptor Cross-Talk; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics / Q000378:metabolism*; D050794:STAT1 Transcription Factor / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D025841:Small Ubiquitin-Related Modifier Proteins / Q000378:metabolism*
D004268:DNA-Binding Proteins; D018836:Inflammation Mediators; D008024:Ligands; D000071518:Liver X Receptors; C000605213:NR1H3 protein, human; C000605215:Nr1h3 protein, rat; D057093:Orphan Nuclear Receptors; D018160:Receptors, Cytoplasmic and Nuclear; D050794:STAT1 Transcription Factor; D025841:Small Ubiquitin-Related Modifier Proteins; C494081:Stat1 protein, rat; D007371:Interferon-gamma