[Effect of persistent pollutants on the rat liver antioxidant status].
The hepatic antioxidant status was studied in the rats poisoned by a Sovol mixture of polychlorobiphenyls in different doses. Exposure to the toxic agent in a dose of 600 mg/kg leads to the accumulation of peroxidation products, the drop of reduced gluthatione, NADPH and the suppressed activities of superoxide dismutase, catalase, glutathione peroxidase, and glutathione-S-transferase. The findings suggest that severe oxidant stress develops in liver tissue, which may be one of the leading mechanisms responsible for the toxicity of biphenyls.
Agletdinov
E F
EF
Nikonorov
A A
AA
Kamilov
F Kh
FKh
D000818:Animals; D002374:Catalase / Q000378:metabolism*; D004195:Disease Models, Animal; D004785:Environmental Pollutants / Q000633:toxicity*; D016166:Free Radical Scavengers / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism*; D005982:Glutathione Transferase / Q000378:metabolism*; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D011078:Polychlorinated Biphenyls / Q000633:toxicity; D051381:Rats; D013482:Superoxide Dismutase / Q000378:metabolism*
D004785:Environmental Pollutants; D016166:Free Radical Scavengers; D011078:Polychlorinated Biphenyls; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005982:Glutathione Transferase