Polymorphonuclear neutrophils and T lymphocytes: strange bedfellows or brothers in arms?
Polymorphonuclear neutrophils (PMN) are linked invariably to the innate immune response, particularly to the defence against bacterial infection. T lymphocytes are studied mainly in virus infections, the defence against tumours, the development and progression of chronic inflammatory processes, in autoimmune phenomena and in materno-fetal tolerance. There is, however, increasing evidence for communication and interactions between PMN and T cells that we discuss here in the context of different physiological and pathological conditions, including acute and chronic inflammatory disease, defence against tumours, and maintenance of pregnancy.
Müller
Ingrid
I
Department of Immunology, Faculty of Medicine, Imperial College London, London W2 1PG, UK.
Munder
Markus
M
Kropf
Pascale
P
Hänsch
Gertrud Maria
GM
D000818:Animals; D015551:Autoimmunity / Q000276:immunology; D001424:Bacterial Infections / Q000276:immunology* / Q000382:microbiology; D002450:Cell Communication / Q000276:immunology; D016207:Cytokines / Q000276:immunology* / Q000378:metabolism; D005260:Female; D006801:Humans; D007110:Immunity, Active; D007113:Immunity, Innate; D007249:Inflammation / Q000276:immunology* / Q000378:metabolism / Q000382:microbiology; D009369:Neoplasms / Q000276:immunology / Q000378:metabolism; D009504:Neutrophils / Q000276:immunology* / Q000382:microbiology; D011247:Pregnancy; D013601:T-Lymphocytes / Q000276:immunology* / Q000382:microbiology
D016207:Cytokines