Platelet-rich plasma: current concepts and application in sports medicine.
Platelet-rich plasma is defined as autologous blood with a concentration of platelets above baseline values. Platelet-rich plasma has been used in maxillofacial and plastic surgery since the 1990s; its use in sports medicine is growing given its potential to enhance muscle and tendon healing. In vitro studies suggest that growth factors released by platelets recruit reparative cells and may augment soft-tissue repair. Although minimal clinical evidence is currently available, the use of platelet-rich plasma has increased, given its safety as well as the availability of new devices for outpatient preparation and delivery. Its use in surgery to augment rotator cuff and Achilles tendon repair has also been reported. As the marketing of platelet-rich plasma increases, orthopaedic surgeons must be informed regarding the available preparation devices and their differences. Many controlled clinical trials are under way, but clinical use should be approached cautiously until high-level clinical evidence supporting platelet-rich plasma efficacy is available.
Department of Orthopaedic Surgery, NYU Hospital for Joint Diseases, New York, NY 10003, USA.
Michael P
MP
Hall
Phillip A
PA
Band
Robert J
RJ
Meislin
Laith M
LM
Jazrawi
Dennis A
DA
Cardone
D000125:Achilles Tendon / Q000293:injuries / Q000601:surgery; D016118:Anterior Cruciate Ligament / Q000601:surgery; D000070598:Anterior Cruciate Ligament Injuries; D006801:Humans; D009141:Musculoskeletal System / Q000293:injuries*; D009985:Orthopedics / Q000639:trends; D053657:Platelet-Rich Plasma; D017006:Rotator Cuff / Q000601:surgery; D000070636:Rotator Cuff Injuries; D013178:Sports Medicine / Q000639:trends; D013708:Tendon Injuries / Q000601:surgery; D013716:Tennis Elbow / Q000628:therapy; D035703:Therapies, Investigational; D014945:Wound Healing / Q000502:physiology