Experimental lagochilascariosis in X-chromosome-linked immunodeficient mice.
Lagochilascaris minor is the etiological agent of lagochilascariosis, a disease that affects the neck region and causes exudative abscesses, with eggs, adult parasites and L3/L4 larvae in the purulent exudates. Mice are now considered to be intermediate hosts for the parasite. To determine the pattern of infection in B1 cell-deficient mice, experimental lagochilascariosis was studied in BALB/c and X-chromosome-linked immunodeficient (xid) mice. BALB.xid-infected mice showed lower numbers of larvae. Third-stage larvae, fourth-stage larvae and adult parasites were found in both strains. BALB/c mice produced IgM, IgG, IgA and IgE against the crude extract and secreted/excreted antigens of the parasite. On the other hand, BALB.xid mice did not produce IgM and produced lower levels of IgG and IgA, and similar quantities of IgE.
Department of Microbiology, Immunology, Parasitology and Pathology, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia, GO, Brazil.
Jaqueline Aparecida Gleice
JA
de Freitas
Mariana Félix de Souza
MF
Prudente
Mara Silvia
MS
Carvalhaes
D000818:Animals; D000909:Antibodies, Helminth / Q000276:immunology*; D000947:Antigens, Helminth / Q000276:immunology*; D017191:Ascaridida Infections / Q000276:immunology* / Q000469:parasitology; D001199:Ascaridoidea / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D006790:Host-Parasite Interactions / Q000276:immunology*; D007132:Immunoglobulin Isotypes / Q000096:biosynthesis / Q000097:blood; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D018101:Mice, Inbred mdx; D013997:Time Factors
D000909:Antibodies, Helminth; D000947:Antigens, Helminth; D007132:Immunoglobulin Isotypes