The dynamics of HDAC activity on memory formation.
Histone deacetylases (HDACs) have previously been shown to be critical for the formation of long-term memories. Recent findings now show that a specific HDAC isoform, HDAC2, negatively regulates formation of hippocampus-dependent memory. These recent findings published in Nature highlight potential new therapeutic interventions for the treatment of memory impairments associated with human neurological disorders.
Department of Neurobiology, Evelyn F. McKnight Brain institute, The University of Alabama at Birmingham, Birmingham AL 35294-2182, USA.
Nicola M
NM
Grissom
Farah D
FD
Lubin