Importance of leuprolide acetate variable dosing for precocious puberty: a range of acceptable suppression.
OBJECTIVE
The effect of the variation in hormonal suppression on bone maturation, growth velocity, and adult height prediction was examined during treatment with leuprolide acetate for central precocious puberty (CPP).


METHODS
Ten girls on variable doses of Lupron were studied for one year. Height, weight, body mass index, luteinizing hormone (LH), estradiol, and growth velocity were measured every 3 months. Bone age and predicted height were assessed every 6 months.


RESULTS
LH range changed from 0.5-1.4 IU/I to 0.1-2.8 IU/I. The average Lupron dose decreased from 0.33 +/- 0.11 to 0.26 +/- 0.08 mg/kg. Predicted adult height averaged 158.33 +/- 9.5cm at the start of the study and increased to 161.45 +/- 6.26 cm (p <0.01). LH and estradiol did not correlate with the rate of bone maturation, growth velocity, predicted height, or with leuprolide dose.


CONCLUSIONS
Variable dosing of leuprolide acetate is needed to achieve similar amounts of hormonal suppression, yet small changes in dose did not significantly change LH or estradiol levels or predicted height.
Division of Pediatric Endocrinology, Rady Children's Hospital San Diego, Department of Pediatrics, Division of Pediatric Endocrinology, University of California San Diego, San Diego, CA 92123, USA.
Daniela
D
Cohen
Mona
M
Janfaza
Karen O
KO
Klein
D001827:Body Height / Q000187:drug effects / Q000502:physiology; D015992:Body Mass Index; D001846:Bone Development / Q000187:drug effects / Q000502:physiology; D001842:Bone and Bones / Q000187:drug effects / Q000502:physiology; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D004958:Estradiol / Q000097:blood; D005260:Female; D005300:Fertility Agents, Female / Q000008:administration & dosage / Q000627:therapeutic use*; D006128:Growth / Q000187:drug effects / Q000502:physiology; D006801:Humans; D016729:Leuprolide / Q000008:administration & dosage / Q000627:therapeutic use*; D007986:Luteinizing Hormone / Q000097:blood; D011629:Puberty, Precocious / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology
D005300:Fertility Agents, Female; D004958:Estradiol; D007986:Luteinizing Hormone; D016729:Leuprolide