A new cytotoxic 19-nor-cardenolide from the latex of Antiaris toxicaria.
A new nor-cardenolide, named toxicarioside H (1), was isolated from the latex of Antiaris toxicaria (Pers.) Lesch (Moraceae). Its structure was elucidated on the basis of HRFAB-MS and spectroscopic techniques (IR, UV, 1D and 2D NMR). Compound 1 showed significant cytotoxicity against K562, SGC-7901, SMMC-7721, and HeLa cell lines in vitro by MTT method.
Dai
Hao-Fu
HF
Key Laboratory of Tropical Crop Biotechnology, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China. hfdai@yahoo.cn
Gan
Yu-Juan
YJ
Que
Dong-Mei
DM
Wu
Jiao
J
Wen
Zhen-Chang
ZC
Mei
Wen-Li
WL
D031621:Antiaris / Q000737:chemistry*; D002298:Cardenolides / Q000302:isolation & purification* / Q000494:pharmacology*; D002301:Cardiac Glycosides / Q000302:isolation & purification* / Q000494:pharmacology*; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D006801:Humans; D007840:Latex / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy
D002298:Cardenolides; D002301:Cardiac Glycosides; D007840:Latex; C545314:toxicarioside H