[Metabolic study of ginsenoside Re in rats].
OBJECTIVE
To systemically study the metabolism of ginsenoside Re in rats.


METHODS
Six SD rats were used divided into 3 groups. After oral administration of ginsenoside Re at a dosage of 100 mg x kg(-1), feces were collected at 12, 24, 36, 48, and 60 h. The microbial transformation metabolites of ginsenoside Re were used as standard references. HPLC-ESI-MS/MS analysis was used in the metabolism studies.


RESULTS
Six metabolites of ginsenoside Re were detected in rat feces by HPLC-ESI-MS/MS analysis. Their structures were identified as 20(S)-ginsenoside Rg2, 20(S)-ginsenoside Rh1, 20(R)-ginsenoside Rh1, ginsenoside F1, 3-oxo-ginsenoside Rh1 and protopanaxatriol.


CONCLUSIONS
Ginsenoside Re has the same metabolic pathway with microorganisms, to some extent, justified the use of microbial models for mammalian metabolism studies.
Medical College, Nantong University, Nantong 226001, China. chenguangtong@tom.com
Guangtong
G
Chen
Min
M
Yang
Dean
D
Guo
D000284:Administration, Oral; D000818:Animals; D001711:Biotransformation; D005243:Feces / Q000737:chemistry; D036145:Ginsenosides / Q000032:analysis / Q000378:metabolism*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
D036145:Ginsenosides; C049864:ginsenoside Re