The dynamics of HDAC activity on memory formation.
Histone deacetylases (HDACs) have previously been shown to be critical for the formation of long-term memories. Recent findings now show that a specific HDAC isoform, HDAC2, negatively regulates formation of hippocampus-dependent memory. These recent findings published in Nature highlight potential new therapeutic interventions for the treatment of memory impairments associated with human neurological disorders.
Grissom
Nicola M
NM
Department of Neurobiology, Evelyn F. McKnight Brain institute, The University of Alabama at Birmingham, Birmingham AL 35294-2182, USA.
Lubin
Farah D
FD