Lactate is an alternative energy fuel to glucose in neurons under anesthesia.
The uptake of [14C]lactate was measured in the brains of mice anesthetized with pentobarbital or chloral hydrate. The results showed significant increase of the [14C]lactate uptake in the brain under both anesthesia. Despite energy metabolism in the brain being suppressed by both pentobarbital and chloral hydrate, the [14C]lactate uptake was unexpectedly increased under anesthesia. [14C]Lactate uptake in rat brain injured by infusion of quinolic acid was significantly decreased, and the reduction of [14C]lactate uptake was parallel to neural cell death, suggesting that exogenous lactate might be selectively taken up by neuron. These results indicated that lactate rather than glucose might serve as an energy substrate for neuron in intact brain under anesthesia.
Yamada
Akifumi
A
Division of Health Sciences, Graduate School of Medicine, Osaka University, Osaka, Japan. yamaaki@sahs.med.osaka-u.ac.jp
Yamamoto
Keisuke
K
Imamoto
Natsumi
N
Momosaki
Sotaro
S
Hosoi
Rie
R
Yamaguchi
Masatoshi
M
Inoue
Osamu
O
D018681:Anesthetics, General / Q000494:pharmacology*; D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D001923:Brain Chemistry / Q000187:drug effects* / Q000502:physiology; D002250:Carbon Radioisotopes; D016923:Cell Death / Q000187:drug effects / Q000502:physiology; D002697:Chloral Hydrate / Q000494:pharmacology; D015536:Down-Regulation / Q000187:drug effects / Q000502:physiology; D004734:Energy Metabolism / Q000187:drug effects* / Q000502:physiology; D005947:Glucose / Q000378:metabolism*; D019344:Lactic Acid / Q000378:metabolism*; D008297:Male; D051379:Mice; D009410:Nerve Degeneration / Q000139:chemically induced / Q000378:metabolism / Q000503:physiopathology; D010424:Pentobarbital / Q000494:pharmacology; D017378:Quinolinic Acid / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
D018681:Anesthetics, General; D002250:Carbon Radioisotopes; D019344:Lactic Acid; D002697:Chloral Hydrate; D017378:Quinolinic Acid; D010424:Pentobarbital; D005947:Glucose