Calprotectin levels in the cerebrospinal fluid reflect disease activity in multiple sclerosis.
Calprotectin is produced by activated monocytes and microglia, and cerebrospinal fluid (CSF) levels could be a marker of neuroinflammation. Calprotectin was detectable in CSF from 13.8% of normal controls, compared to 90.5% of patients with neurological infections (p<0.001). In CSF from patients with multiple sclerosis (MS) and clinically isolated demyelinating syndrome, calprotectin was detected in 64.7% within 2 weeks after symptom debut compared to 30.8% between 2 and 4 weeks and 17.0% thereafter (p<0.001). We conclude that CSF calprotectin reflects the disease activity in MS but does not discriminate between MS and other inflammatory or infectious conditions.
Berg-Hansen
Pål
P
Department of Neurology, Oslo University Hospital Ullevål, Oslo, Norway.
Vandvik
Bodvar
B
Fagerhol
Magne
M
Holmøy
Trygve
T
D000328:Adult; D015415:Biomarkers / Q000134:cerebrospinal fluid; D002490:Central Nervous System / Q000276:immunology / Q000503:physiopathology; D002555:Cerebrospinal Fluid / Q000737:chemistry / Q000276:immunology / Q000378:metabolism; D003937:Diagnosis, Differential; D004660:Encephalitis / Q000134:cerebrospinal fluid* / Q000175:diagnosis* / Q000276:immunology; D005260:Female; D006801:Humans; D039841:Leukocyte L1 Antigen Complex / Q000032:analysis / Q000134:cerebrospinal fluid*; D008297:Male; D017628:Microglia / Q000276:immunology / Q000378:metabolism; D008875:Middle Aged; D009000:Monocytes / Q000276:immunology / Q000378:metabolism; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid* / Q000175:diagnosis* / Q000276:immunology; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D013997:Time Factors
D015415:Biomarkers; D039841:Leukocyte L1 Antigen Complex