[Anti-tumor activity and mechanism with SSCE of Spatholobus suberctus].
OBJECTIVE
To observe the effect of anti-tumor and mechanism of the extract of Spatholobus suberctus (SSCE) in vivo.


METHODS
The mouse model of Lewis lung carcinoma was used to investigate the effects of SSCE on tumor growth and metastasis. Furthermore, we explored the mechanism of anti-tumor by analyze the cell cycle and determine the apoptosis.


RESULTS
The studies demonstrated that the tumor inhibitory rate of SSCE in low dose group was the highest (30.65%) on Lewis lung cancer. SSCE can resist metastasis, at the same time, it can induce cell cycle arrested in G1 phase, whereas, there was no significant difference in apoptotic rate each group.


CONCLUSIONS
We verified that SSCE exits anti-tumor effect and resist metastasis, furthermore, it can arrest function cell in G1 phase.
Beijing Hospital of Chinese Medicine Alias Capital University of Medical Sciences, Beijing 100010, China. dbccfq@tom.com
Qi
Q
Fu
Yong
Y
Tang
Xiaoqin
X
Luo
Guowang
G
Yang
Wei
W
He
Xiaomin
X
Wang
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D018827:Carcinoma, Lewis Lung / Q000188:drug therapy / Q000503:physiopathology; D002453:Cell Cycle / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004195:Disease Models, Animal; D007887:Fabaceae / Q000737:chemistry*; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000503:physiopathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use
D000970:Antineoplastic Agents; D010936:Plant Extracts