Disinhibition due to disruption of the orbitofrontal circuit treated successfully with carbamazepine: a case series.
The frontal-subcortical pathways play a role in governing behavior. Injury may disrupt their functioning and produce neuropsychiatric symptoms. The authors discuss the kindling theory in the possible production of these symptoms, which significantly improved with the potent antikindling agent, carbamazepine.
Eastern Virginia Medical School, Department of Psychiatry and Behavioral Sciences, 825 Fairfax Ave., Norfolk, VA 23507, USA. SpiegeDR@evms.edu
David R
DR
Spiegel
Jessica
J
Burgess
Derek
D
Samuels
Rishi
R
Laroia
Stephen
S
Kirshenbaum
D000328:Adult; D001927:Brain Diseases / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy*; D002220:Carbamazepine / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D005625:Frontal Lobe / Q000000981:diagnostic imaging / Q000187:drug effects; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology; D008875:Middle Aged; D011619:Psychotropic Drugs / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D044465:White People
D011619:Psychotropic Drugs; D002220:Carbamazepine