Bioinformatics research on chronic superficial gastritis of Pi-deficiency syndrome by gene arrays.
OBJECTIVE
To determine the bioinformatical characteristics of differential gene expression in patients with chronic superficial gastritis (CSG) with the Pi-deficiency syndrome (PDS) and those of the non-Pi-deficiency syndrome (non-PDS), i.e. patients of CSG with Pi-Wei dampnese-heat syndrome and healthy persons.


METHODS
With the BRB-Array Tools software package, original data collection and bioinformatic: analysis of gene arrays were conducted in 6 CSG patients of PDS (CSG-PDS), 6 CSG patients of non-PDS (CSG-nPDS), and 6 healthy volunteers (Normal).


RESULTS
Compared with non-PDS, the gene expressions: in PDS with regards to protein synthesis, energy metabolism, immune reaction and ionic transport tended to be down-regulated, while those concerning secretion, cytoskeleton and ubiquitinization were up-regulated dominantly.


CONCLUSIONS
The two kinds of samples, CSG-PDS/Normal and CSG-PDS/CSG-nPDS, have their respective gene expression profiles with different characteristics. Gene expression profile has certain referential significance in syndrome classification.
Chen
Yu-long
YL
Pi-Wei Institute, Guangzhou University of Chinese Medicine, Guangzhou, China.
Chen
Wei-wen
WW
Wang
Ying-fang
YF
Li
Ru-liu
RL
Guo
Wen-feng
WF
Lao
Shao-Xian
SX
Wang
Jian-hua
JH
Huang
Sui-ping
SP
D002908:Chronic Disease; D016000:Cluster Analysis; D019295:Computational Biology; D005756:Gastritis / Q000235:genetics*; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis; D013577:Syndrome