Impact of hyperthermal rotary blood pump surfaces on blood clotting behavior: an approach.
The influence of heat dissipating systems, such as rotary blood pumps, was investigated. Titanium cylinders as rotary blood pump housing dummies were immersed in porcine blood and constantly tempered at specific temperatures (37-60 degrees C) over a defined period of time. The porcine blood was anticoagulated either by low heparin dosage or citrate. At frequent intervals, samples were taken for blood analysis and the determination of the plasmatic coagulation cascade. Blood parameters do not alter at surface temperatures below 50 degrees C. Hyperthermia-induced hemolysis could be confirmed. The plasmatic coagulation cascade is terminated at surface temperatures exceeding 55 degrees C. The adhesion of blood constituents on surfaces is temperature and time dependent, and structural changes of adhesions and blood itself were detected.
Hamilton
Kathrin F
KF
Applied Medical Engineering, Helmholtz Institute for Biomedical Engineering, RWTH Aachen University, Aachen, Germany. hamilton@hia.rwth-aachen.de
Schlanstein
Peter C
PC
Mager
Ilona
I
Schmitz-Rode
Thomas
T
Steinseifer
Ulrich
U
D000268:Adhesiveness; D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology; D001777:Blood Coagulation / Q000187:drug effects; D019343:Citric Acid / Q000494:pharmacology; D004867:Equipment Design; D006353:Heart-Assist Devices / Q000009:adverse effects*; D006461:Hemolysis; D006493:Heparin / Q000494:pharmacology; D006358:Hot Temperature; D008422:Materials Testing; D012399:Rotation; D013499:Surface Properties; D013552:Swine; D013997:Time Factors; D014025:Titanium
D000925:Anticoagulants; D019343:Citric Acid; D006493:Heparin; D014025:Titanium