[Apoptosis of mononuclear cells and dead leukocytes in venous blood of septic patients].
Apoptosis of mononuclear cells, dead leukocyte and CD95+ lymphocytes content in venous blood of 15 patients were evaluated by flow cytometry within 2-3 day after diagnosis of sepsis. The number of CD95+ lymphocytes increased in 40% of the cases and that of lymphocytes expressing Fas receptor decreased in 27%. The number of mononuclear cells in venous blood increased 7 times compared with physiological norm; this rise was a reliable predictor of the unfavourable outcome of the disease. Elimination of dead leukocytes by granulocytophoresis produced good therapeutic result.
Borovkova
I V
IV
Khvatov
V B
VB
Aleksandrova
I V
IV
Reĭ
S I
SI
Il'inskiĭ
M E
ME
Abakumov
M M
MM
D000328:Adult; D017209:Apoptosis / Q000502:physiology*; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D007963:Leukocytes, Mononuclear / Q000473:pathology*; D008214:Lymphocytes / Q000276:immunology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D018805:Sepsis / Q000097:blood / Q000473:pathology*; D012720:Severity of Illness Index; D019014:fas Receptor / Q000276:immunology
D019014:fas Receptor