Risk factors for idiopathic pulmonary fibrosis in a Mexican population. A case-control study.
The etiology of idiopathic pulmonary fibrosis (IPF) remains poorly understood, but some studies have suggested that cigarette smoking or other occupational or environmental exposures, diabetes mellitus, or gastroesophageal reflux may play a role. In this study we evaluated the clinical records of a group of 97 consecutive patients with IPF, and 560 patients suffering 5 different respiratory disorders that were examined as controls: asthma (n=111), chronic obstructive pulmonary disease (n=132), squamous cell lung carcinoma (n=118), lung adenocarcinoma (n=101) and patients with otorhinolaryngology problems but without lung disease (n=98). In bivariate analyses male sex, diabetes mellitus and being former cigarette smoker were associated with IPF. After adjusting by these variables, multivariate analysis revealed that type 2 diabetes mellitus [11.3% in IPF patients vs 2.9% in controls, OR=4.3 (95% CI: 1.9-9.8), p<0.0001] was an independent risk factor associated to IPF. Our results provide additional evidence of a putative relationship between DM2 and idiopathic pulmonary fibrosis. Experimental research is necessary for thorough assessment of the pathogenic mechanisms involved in this association.
García-Sancho Figueroa
Ma Cecilia
MC
Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, México DF, México.
Carrillo
Guillermo
G
Pérez-Padilla
Rogelio
R
Fernández-Plata
Ma Rosario
MR
Buendía-Roldán
Ivette
I
Vargas
Mario H
MH
Selman
Moisés
M
D002294:Carcinoma, Squamous Cell / Q000150:complications*; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D005260:Female; D006801:Humans; D054990:Idiopathic Pulmonary Fibrosis / Q000209:etiology*; D008175:Lung Neoplasms / Q000150:complications*; D008297:Male; D008800:Mexico; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects*