[Damage-associated molecular patterns and chronic diseases].
Molecules of damage-associated molecular patterns (DAMPs) are a class of substances released to intercellular space or peripheral blood by tissues or cells which are stimulated by insults, ischemia or stress. DAMP molecules can be recognized by Toll like receptors, Nod1-like receptors, or Rig-I like receptors and induce autoimmunity or immune tolerance, which play critical roles in various chronic diseases such as arthritis, atherosclerosis, cancer and systemic lupus erythematosus. DAMP molecules include high-mobility group B protein 1, heat shock proteins and S100 proteins etc. The identification of DAMP molecules and clarification of mechanisms of their action will greatly contribute to reveal the pathological mechanisms of chronic diseases and provide a great opportunity to develop the new strategies for the diagnosis, prevention and treatment for these diseases.
Institute of Meteria Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Hong-Zhen
HZ
Yang
Wen-Feng
WF
Cai
Zhuo-Wei
ZW
Hu
D000818:Animals; D002908:Chronic Disease; D024243:HMGB1 Protein; D006360:Heat-Shock Proteins; D006801:Humans; D007249:Inflammation; D009418:S100 Proteins; D051193:Toll-Like Receptors
D024243:HMGB1 Protein; D006360:Heat-Shock Proteins; D009418:S100 Proteins; D051193:Toll-Like Receptors