Cholesterol worships a new idol.
The growing worldwide epidemic of cardiovascular disease suggests that new therapeutic strategies are needed to complement statins in the lowering of cholesterol levels. In a recent paper in Science, Tontonoz and colleagues have identified Idol as a protein that can control cholesterol levels by regulating the stability of the low-density lipoprotein receptor; inhibiting the activity of Idol could provide novel approaches for the treatment of cardiovascular disease.
Schulman
Ira G
IG
Center for Molecular Design and Department of Pharmacology, University of Virginia Health System, Charlottesville, VA 22908, USA. igs4c@virginia.edu
D000818:Animals; D002784:Cholesterol / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D000071518:Liver X Receptors; D051379:Mice; D057093:Orphan Nuclear Receptors / Q000378:metabolism; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism*
D000071518:Liver X Receptors; D057093:Orphan Nuclear Receptors; D002784:Cholesterol; D044767:Ubiquitin-Protein Ligases