Bone and wound healing augmentation with platelet-rich plasma.
Over the past two decades, autologous platelets that have been sequestered, concentrated, and mixed with thrombin to generate growth factor-concentrated platelet-rich plasma for application to bone and wounds to aide healing have been a subject of great interest. This article reviews the literature related to the use of autologous platelet-rich plasma in bone and wound healing, and reviews the processes necessary to secure a high concentration of viable platelets. Although not yet definitive, autologous platelet-rich plasma has been shown to be safe, reproducible, and effective in mimicking the natural process of bone and wound healing.
Smith
Simon E
SE
Australasian College of Podiatric Surgeons, Australia. simonsmithpod@optusnet.com.au
Roukis
Thomas S
TS
D000818:Animals; D001842:Bone and Bones / Q000293:injuries / Q000601:surgery; D002356:Cartilage / Q000293:injuries / Q000601:surgery; D048091:Guided Tissue Regeneration; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000494:pharmacology; D019647:Oral Surgical Procedures; D019637:Orthopedic Procedures; D053657:Platelet-Rich Plasma; D013708:Tendon Injuries / Q000601:surgery; D014182:Transplantation, Autologous; D014945:Wound Healing
D036341:Intercellular Signaling Peptides and Proteins