HeartMate left ventricular assist system exchange: results and technical considerations.
The duration times of left ventricular assist system (LVAS) support have increased because of prolonged wait times for transplant and the more frequent use of devices for destination therapy. The HeartMate LVAS, the only device approved for bridge to transplant and destination therapy, has limited durability, making replacement increasingly necessary. Since 1996, we have exchanged 19 left ventricular assist devices in 15 patients (11 men: mean age, 57.1 years; range, 33-77 years). Most of the devices (14) were replaced with the HeartMate vented electric/extended-lead vented electric pump; five devices were exchanged for a HeartMate II LVAS. Bearing failure was the most frequent reason for exchange (15 of 19 pumps); four of the 19 pumps also had active device-related infections at the time of exchange. There were no early deaths (30 days). Overall survival (Kaplan-Meier) was 85% at 1 year, 67% at 2 years, and 56% at 3 years. Three patients had transplants (mean, 518 days); six patients died during support (mean, 934 days), and six patients remain on LVAS support (mean, 1,219 days). One patient has been on device for over 6 years. Left ventricular assist devices exchange is becoming increasingly likely and can be associated with acceptably low-operative mortality rates and good intermediate-term survival.
Department Cardiovascular Surgery, Sharp Memorial Hospital, San Diego, California, USA. robandtl@aol.com
Robert M
RM
Adamson
Walter P
WP
Dembitsky
Sam
S
Baradarian
Joseph
J
Chammas
Brian
B
Jaski
Peter
P
Hoagland
Vicki
V
McCalmont
Kristi
K
Ortiz
Marsha
M
Stahovich
Suzanne
S
Chillcott
D000328:Adult; D000368:Aged; D013504:Cardiovascular Surgical Procedures / Q000379:methods*; D020878:Device Removal / Q000379:methods* / Q000706:statistics & numerical data; D005260:Female; D006333:Heart Failure / Q000401:mortality / Q000628:therapy*; D006352:Heart Ventricles; D006353:Heart-Assist Devices; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D013995:Time