Hemodynamics of Cerebral Aneurysms.
The initiation and progression of cerebral aneurysms are degenerative processes of the arterial wall driven by a complex interaction of biological and hemodynamic factors. Endothelial cells on the artery wall respond physiologically to blood-flow patterns. In normal conditions, these responses are associated with nonpathological tissue remodeling and adaptation. The combination of abnormal blood patterns and genetics predisposition could lead to the pathological formation of aneurysms. Here, we review recent progress on the basic mechanisms of aneurysm formation and evolution, with a focus on the role of hemodynamic patterns.
Sforza
Daniel M
DM
Center for Computational Fluid Dynamics, George Mason University, Fairfax, Virginia 22030.
Putman
Christopher M
CM
Cebral
Juan Raul
JR