6-Hydroxymethyl-1-phenazine-carboxamide and 1,6-phenazinedimethanol from a marine bacterium, Brevibacterium sp. KMD 003, associated with marine purple vase sponge.
Two new antibacterial phenazines were isolated from the culture broth of Brevibacterium sp. KMD 003 obtained from a marine purple vase sponge of the genus Callyspongia, collected in Kyeongpo, Gangwondo, Korea. The structures of these compounds were determined to be 6-hydroxymethyl-1-phenazine-carboxamide (1) and 1,6-phenazinedimethanol (2) through analyses of HR-EI-MS and NMR data. Compounds 1 and 2 showed antibacterial activities against Enterococcus hirae and Micrococcus luteus with 5 microM MIC values.
Natural Products Research Center, Korea Institute of Science and Technology, Gangneung, Gangwon-do, Korea.
Eun Ju
EJ
Choi
Hak Cheol
HC
Kwon
Jungyeob
J
Ham
Hyun Ok
HO
Yang
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001951:Brevibacterium / Q000378:metabolism*; D047128:Callyspongia / Q000382:microbiology*; D009682:Magnetic Resonance Spectroscopy; D010619:Phenazines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
C545888:1,6-phenazinedimethanol; C545887:6-hydroxymethyl-1-phenazinecarboxamide; D000900:Anti-Bacterial Agents; D010619:Phenazines