Porous bioactive diopside (CaMgSi(2)O(6)) ceramic microspheres for drug delivery.
Ideal bioceramic microspheres for bone regeneration need to be bioactive and degradable, but at the same time possess a controlled drug-release ability. The main disadvantage of the currently available microspheres is their failure to combine these properties. The aim of this study is to develop bioactive ceramic microspheres with optimal properties for use in bone-tissue regeneration. In this study, we utilize diopside (CaMgSi(2)O(6), DP) with proven excellent bioactivity and degradation ability to develop microspheres by controlling their porosity and size, and further modify their surface with polymer to enhance and control their drug-loading/release ability. The phase composition, surface and inner microstructure, and porosity of DP microspheres were tested. Results indicate that carbon powders as porogens with various contents determined the porosity of the porous DP microspheres. The drug-loading and release ability of dexamethazone (DEX) from porous DP microspheres was regulated by their porosity and size. Poly(lactide-co-glycolide) modification forms a film on the surface of DP microspheres and resulted in an enhanced DEX-loading and release ability of the microspheres. Results presented here indicate that the developed DP microspheres have the potential to be used as bioactive filling materials for bone-tissue regeneration.
Biomaterials and Tissue Engineering Research Unit, School of AMME, the University of Sydney, Sydney, NSW 2006, Australia.
Chengtie
C
Wu
Hala
H
Zreiqat
D001826:Body Fluids / Q000737:chemistry*; D002516:Ceramics / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000737:chemistry*; D003907:Dexamethasone / Q000008:administration & dosage / Q000737:chemistry*; D004058:Diffusion; D004337:Drug Carriers; D004339:Drug Compounding / Q000379:methods; D008422:Materials Testing; D008863:Microspheres; D016062:Porosity; D012824:Silicic Acid / Q000737:chemistry*
D003692:Delayed-Action Preparations; D004337:Drug Carriers; D012824:Silicic Acid; C074224:diopside; D003907:Dexamethasone