Gold(III) chloride catalyzed synthesis of 1-cyanoisoindoles.
A two-step synthesis of 1-cyanoisoindoles starting from ethynylbenzaldehyde is presented. The key step is a mild, high-yielding, gold-catalyzed rearrangement of N-allylic aminonitriles.
Research Group SynBioC, Department of Organic Chemistry, Faculty of Bioscience Engineering, Ghent University, Coupure links 653, B-9000 Ghent, Belgium.
Thomas S A
TS
Heugebaert
Christian V
CV
Stevens
D002384:Catalysis; D003500:Cyclization; D017612:Gold Compounds / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009570:Nitriles / Q000138:chemical synthesis* / Q000737:chemistry
D017612:Gold Compounds; D007211:Indoles; D009570:Nitriles; C038016:gold chloride