Magnetic wire traps and programmable manipulation of biological cells.
We present a multiplex method, based on microscopic programmable magnetic traps in zigzag wires patterned on a platform, to simultaneously apply directed forces on multiple fluid-borne cells or biologically inert magnetic microparticles or nanoparticles. The gentle tunable forces do not produce damage and retain cell viability. The technique is demonstrated with T-lymphocyte cells remotely manipulated (by a joystick) along desired trajectories on a silicon surface with average speeds up to 20 microm/s.
Vieira
G
G
Department of Physics, The Ohio State University, Columbus, Ohio 43210, USA.
Henighan
T
T
Chen
A
A
Hauser
A J
AJ
Yang
F Y
FY
Chalmers
J J
JJ
Sooryakumar
R
R
D003035:Cobalt / Q000737:chemistry; D003584:Cytological Techniques / Q000379:methods*; D055590:Electromagnetic Phenomena; D006801:Humans; D007501:Iron / Q000737:chemistry; D008280:Magnetics; D008853:Microscopy / Q000379:methods*; D053758:Nanoparticles / Q000737:chemistry; D013601:T-Lymphocytes / Q000166:cytology
D003035:Cobalt; D007501:Iron