[An experimental model of studynig radiation oppression of antitumor resistance].
In experiences on mice (CBA x C57Bl) F1 the experimental model for studying action of radiation on antineoplastic resistance is developed. Adequate ways of statistical processing of the received data testifying to amplification of tumoral growth in the irradiated organism are offered. The use of model of the solid form of the tumor developing after introduction in a shin of a hinder leg of the mouse of 1000 cells ascetic carcinoma of Ehrlich in a combination to radiating depression of antineoplastic resistance at animals after an irradiation on installation IGUR (137Cs) in a doze 6 Gy is proved. At an estimation of intensity of tumoral growth parameters are recommended: a share of animals with tumors by 30 day after injection, size of the latent period and probability of development of a tumor, and also volume of a tumor by 30 day of supervision. For processing the received results, besides Fisher's widely used criteria, chi2 and the Mann-Whitney, are recommended method Kaplan-Meier and criterion Log-rank. The offered model can become the reliable tool for the decision of the problems worth on a joint of some scientific disciplines: radiobiology, oncology, immunology, pharmacology, etc.
Ivanov
A A
AA
Nasonova
T A
TA
Darenskaia
N G
NG
Dobrynina
O A
OA
Sidorovich
G I
GI
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000276:immunology* / Q000473:pathology; D049109:Cell Proliferation / Q000528:radiation effects*; D002588:Cesium Radioisotopes; D007109:Immunity / Q000528:radiation effects*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011836:Radiation Tolerance; D023041:Xenograft Model Antitumor Assays
D002588:Cesium Radioisotopes