Glycomics and disease markers.
Glycomics is the comprehensive study of all glycans expressed in biological systems. The biosynthesis of glycan relies on a number of highly competitive processes involving glycosyl transferases. Glycosylation is therefore highly sensitive to the biochemical environment and has been implicated in many diseases including cancer. Recently, interest in profiling the glycome has increased owing to the potential of glycans for disease markers. In this regard, mass spectrometry is emerging as a powerful technique for profiling the glycome. Global glycan profiling of human serum based on mass spectrometry has already led to several potentially promising markers for several types of cancer and diseases.
An
Hyun Joo
HJ
Department of Chemistry, University of California, Davis, CA 95616, United States.
Kronewitter
Scott R
SR
de Leoz
Maria Lorna A
ML
Lebrilla
Carlito B
CB
D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D004194:Disease; D054794:Glycomics / Q000379:methods*; D006031:Glycosylation; D006801:Humans; D013058:Mass Spectrometry; D011134:Polysaccharides / Q000378:metabolism
D015415:Biomarkers; D011134:Polysaccharides