Modafinil does not serve as a reinforcer in cocaine abusers.
The purpose of this double-blind, randomized, outpatient study was to evaluate the reinforcing and subjective effects of modafinil (200, 400, or 600 mg) in cocaine abusers. Twelve participants (2 female, 10 male) completed this study, consisting of 3 blocks of 7 sessions; each block tested a difference dose of modafinil. During the first 2 sessions of each block, participants "sampled" 1 of the doses of modafinil, and placebo. These doses of modafinil and placebo were available for the subsequent five choice sessions of the block. In each choice session, participants had an opportunity to administer active or placebo capsules. Modafinil administration did not differ from placebo administration, and subjective-effects ratings were not systematically altered as a function of modafinil dose. Results suggest that modafinil does not have abuse liability in cocaine abusers.
College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, New York, NY 10032, United States.
Suzanne K
SK
Vosburg
Carl L
CL
Hart
Margaret
M
Haney
Eric
E
Rubin
Richard W
RW
Foltin
D000328:Adult; D001559:Benzhydryl Compounds / Q000494:pharmacology* / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D002755:Choice Behavior; D003042:Cocaine / Q000652:urine; D019970:Cocaine-Related Disorders / Q000503:physiopathology / Q000523:psychology* / Q000652:urine; D004311:Double-Blind Method; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D000077408:Modafinil; D018696:Neuroprotective Agents / Q000627:therapeutic use; D010919:Placebos; D012054:Reinforcement, Psychology; D012893:Sleep Wake Disorders / Q000188:drug therapy
D001559:Benzhydryl Compounds; D000697:Central Nervous System Stimulants; D018696:Neuroprotective Agents; D010919:Placebos; D003042:Cocaine; D000077408:Modafinil