Use of therapeutic laser for prevention and treatment of oral mucositis.
Oral mucositis (OM) affects patients who are submitted to hematopoietic stem cell transplantation (HSCT) due to high doses of chemotherapy and/or radiotherapy. The purpose of this investigation was to perform a comparative study of the frequency and evolution of OM among patients subjected to therapeutic laser and to the conventional therapy (use of mouthwash called 'Mucositis Formula'). The patients were subjected to a myeloablative conditioning regimen before the allogeneic HSCT. Twenty-two patients were selected and divided into 2 groups: group I was irradiated with InGaAlP laser (660 nm) and GaAlAs laser (780 nm), 25 mW potency, 6.3J/cm(2) dose, in 10-s irradiation time, followed to conventional treatment; group II was subjected only to the conventional treatment. Both World Health Organization (WHO) scale and the Oral Mucositis Assessment Scale (OMAS) were used to evaluate the results. Data were analyzed by the non-parametric Wilcoxon test, with p<0.05 considered as statistically significant. Group I presented a lower frequency of OM (p=0.02) and lower mean scores, according to WHO and OMAS scales (p<0.01 and p=0.01, respectively). In conclusion, laser reduced the frequency and severity of OM, suggesting that therapeutic laser can be used both as a new form of prevention and treatment of OM.
University Hospital, University of São Paulo, Ribeirão Preto, SP, Brazil. vivikhouri@usp.br
Vivian Youssef
VY
Khouri
Ana Beatriz Pereira Lima
AB
Stracieri
Maria Carolina
MC
Rodrigues
Daniela Aparecida de
DA
Moraes
Fabiano
F
Pieroni
Belinda Pinto
BP
Simões
Júlio César
JC
Voltarelli
D000328:Adult; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D007938:Leukemia / Q000150:complications* / Q000628:therapy; D028022:Low-Level Light Therapy / Q000295:instrumentation / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009067:Mouthwashes / Q000627:therapeutic use; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric; D013280:Stomatitis / Q000209:etiology / Q000517:prevention & control* / Q000628:therapy; D019172:Transplantation Conditioning / Q000009:adverse effects; D016896:Treatment Outcome
D009067:Mouthwashes