[Effect of antipsychotic drugs on life quality of schizophrenic patients: one year follow-up study].
OBJECTIVE
To compare the effect of 7 antipsychotic drugs on the life quality of schizophrenia patients including chlorpromazine, sulpiride, clozapine, risperidone, olanzapine, quetiapine, and aripiprazole.


METHODS
A total of 1,227 stable schizophrenic patients within 5 years onset who took 1 of the 7 study medications as maintenance treatment were followed up for 1 year at 10 China sites. Patients were evaluated by the short form-36 health survey (SF-36) at the baseline and at the end of 1 year.


RESULTS
The life quality was improved obviously at the end of the follow-up. There was significant difference in body pain, vitality, and mental health (P<0.05) among these antipsychotic drugs.


CONCLUSIONS
All 7 antipsychotic drugs can improve the life quality of schizophrenia patients. Atypical antipsychotic drugs, especially olazapine and quetiapine, are superior to typical antipsychotic drugs in improving life quality.
Wuhan Mental Health Center, Wuhan, China.
Maosheng
M
Fang
Lehua
L
Li
Jingping
J
Zhao
Honghui
H
Chen
Meng
M
Ye
Xiaofeng
X
Guo
Zheng
Z
Lu
Xueli
X
Sun
Chuanyue
C
Wang
Shiping
S
Xie
Bin
B
Hu
Tiansheng
T
Guo
Cui
C
Ma
Bo
B
Wang
Luxian
L
Lü
Na
N
Liu
Hong
H
Deng
Qi
Q
Chen
Xiaofang
X
Shang
Fajin
F
Gong
Xiyan
X
Zhang
Xiaolin
X
He
Jianchu
J
Zhou
Yingli
Y
Zhang
D000293:Adolescent; D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001569:Benzodiazepines / Q000627:therapeutic use*; D003987:Dibenzothiazepines / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D000077152:Olanzapine; D011788:Quality of Life; D000069348:Quetiapine Fumarate; D012559:Schizophrenia / Q000188:drug therapy*; D011795:Surveys and Questionnaires; D055815:Young Adult
D014150:Antipsychotic Agents; D003987:Dibenzothiazepines; D001569:Benzodiazepines; D000069348:Quetiapine Fumarate; D000077152:Olanzapine