[Metabolic study of ginsenoside Re in rats].
OBJECTIVE
To systemically study the metabolism of ginsenoside Re in rats.


METHODS
Six SD rats were used divided into 3 groups. After oral administration of ginsenoside Re at a dosage of 100 mg x kg(-1), feces were collected at 12, 24, 36, 48, and 60 h. The microbial transformation metabolites of ginsenoside Re were used as standard references. HPLC-ESI-MS/MS analysis was used in the metabolism studies.


RESULTS
Six metabolites of ginsenoside Re were detected in rat feces by HPLC-ESI-MS/MS analysis. Their structures were identified as 20(S)-ginsenoside Rg2, 20(S)-ginsenoside Rh1, 20(R)-ginsenoside Rh1, ginsenoside F1, 3-oxo-ginsenoside Rh1 and protopanaxatriol.


CONCLUSIONS
Ginsenoside Re has the same metabolic pathway with microorganisms, to some extent, justified the use of microbial models for mammalian metabolism studies.
Chen
Guangtong
G
Medical College, Nantong University, Nantong 226001, China. chenguangtong@tom.com
Yang
Min
M
Guo
Dean
D
D000284:Administration, Oral; D000818:Animals; D001711:Biotransformation; D005243:Feces / Q000737:chemistry; D036145:Ginsenosides / Q000032:analysis / Q000378:metabolism*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
D036145:Ginsenosides; C049864:ginsenoside Re