A computational study on the role of gap junctions and rod Ih conductance in the enhancement of the dynamic range of the retina.
Recent works suggest that one of the roles of gap junctions in sensory systems is to enhance their dynamic range by avoiding early saturation in the first processing stages. In this work, we use a minimal conductance-based model of the ON rod pathways in the vertebrate retina to study the effects of electrical synaptic coupling via gap junctions among rods and among AII amacrine cells on the dynamic range of the retina. The model is also used to study the effects of the maximum conductance of rod hyperpolarization activated current I(h) on the dynamic range of the retina, allowing a study of the interrelations between this intrinsic membrane parameter with those two retina connectivity characteristics. Our results show that for realistic values of I(h) conductance the dynamic range is enhanced by rod-rod coupling, and that AII-AII coupling is less relevant to dynamic range amplification in comparison with receptor coupling. Furthermore, a plot of the retina output response versus input intensity for the optimal parameter configuration is well fitted by a power law with exponent approximately 0.5. The results are consistent with predictions of more theoretical works and suggest that the earliest expression of gap junctions along the rod pathways, together with appropriate values of rod I(h) conductance, has the highest impact on vertebrate retina dynamic range enhancement.
Computational Neuroscience Unit, Okinawa Institute of Science and Technology, Okinawa, Japan. publio@oist.jp
Rodrigo
R
Publio
Rodrigo F
RF
Oliveira
Antonio C
AC
Roque
D000200:Action Potentials; D000465:Algorithms; D025042:Amacrine Cells / Q000502:physiology; D000818:Animals; D004594:Electrophysiology / Q000379:methods*; D017629:Gap Junctions / Q000502:physiology*; D006801:Humans; D008564:Membrane Potentials; D008962:Models, Theoretical; D009474:Neurons / Q000378:metabolism; D012160:Retina / Q000502:physiology*; D017949:Retinal Cone Photoreceptor Cells / Q000502:physiology; D012165:Retinal Ganglion Cells / Q000166:cytology; D017948:Retinal Rod Photoreceptor Cells / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology; D014795:Visual Pathways