[Antineoplastic effect of koumine in mice bearing H22 solid tumor].
OBJECTIVE
To investigate the antitumor effects of koumine in mice bearing H22 solid tumor and its effect on the immune system of the mice.


METHODS
The changes in spleen and tumor weights and blood cell count were observed after koumine treatment in BALB/c athymic mice bearing H22 solid tumor, using normal saline solution and 5-Fu as the controls.


RESULTS
Koumine significantly inhibited the tumor growth in a dose-dependent manner. The spleen index and blood cell counts in koumine group showed no significant differences from those in the saline control group, but higher than those in 5-Fu group.


CONCLUSIONS
Koumine can significantly inhibit the growth of H22 solid tumor without obvious inhibitory effect on the immune system in mice.
College of Pharmacy, Southern Medical University, Guangzhou, China.
Jing
J
Cai
Lin-sheng
LS
Lei
De-biao
DB
Chi
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D005260:Female; D031450:Gelsemium / Q000737:chemistry*; D026121:Indole Alkaloids / Q000302:isolation & purification / Q000627:therapeutic use*; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy* / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D008517:Phytotherapy
D000972:Antineoplastic Agents, Phytogenic; D026121:Indole Alkaloids; C515085:koumine