[From information to the decision: the motives of consent to a vaccine trial for hepatitis B in the Ivory Coast].
Consent represents a key element in any biomedical research on humans. Ideally conceived as free from any constraints, informed by well-understood information and attested to by signature, its authorization in the context of clinical trials conducted in Southern hemisphere countries raises a certain number of difficulties. For this presentation, we studied the motivations of a group of Abidjan women (n=127) to participate or not, with their newborn, in a vaccine protocol trial against Hepatitis B called HEPACI. Consent seemed to stem from various decision-making factors. Firstly, it demonstrated a pragmatic strategy aimed at improving the care of the mother and child regarding healthcare institutions. This was followed by other factors, but according to levels of importance and variable intrications. Trust in the healthcare staff or in the clinical trial managers, the point of view of the spouse, the comprehension of information, the fears regarding the trial (fed or not by rumor phenomena) and the socio-political context also influenced the agreement of the participants.
URSHS, Institut Gustave Roussy, 39, rue Camille Desmoulins, 94805 Villejuif, France.
Christophe
C
Perrey
Awa
A
Ymba
D000293:Adolescent; D000328:Adult; D002986:Clinical Trials as Topic; D015331:Cohort Studies; D007560:Cote d'Ivoire; D005260:Female; D007722:Health Knowledge, Attitudes, Practice; D017325:Hepatitis B Vaccines; D006801:Humans; D007223:Infant; D009042:Motivation; D055815:Young Adult
D017325:Hepatitis B Vaccines