Penetration of ceftazidime into extracellular fluid in patients.
Eight patients were treated with ceftazidime, four of whom had impaired renal function with creatinine clearances below 60 ml/min per 1.73 m2. The levels of ceftazidime in serum and extracellular fluid were determined. Half-life in serum and extracellular fluid was 2.5 and 2.2 h respectively for patients with normal renal function. For patients with impaired renal function the half-life of the drug was 7.9 and 115 h, respectively. The penetration of ceftazidime into extracellular fluid was around 50% in both groups. The levels achieved in both serum and extracellular fluid were satisfactorily high and prolonged, suggesting that a dosage regimen of 1 g twice daily is satisfactory.
Department of Infectious Diseases, University of Lund, General Hospital, S-214 01 Malmö, Sweden.
B
B
Hoffstedt
M
M
Walder
D000368:Aged; D000900:Anti-Bacterial Agents / Q000097:blood / Q000493:pharmacokinetics*; D019540:Area Under Curve; D002442:Ceftazidime / Q000097:blood / Q000493:pharmacokinetics*; D032561:Cotton Fiber; D045604:Extracellular Fluid / Q000378:metabolism*; D005260:Female; D006207:Half-Life; D006801:Humans; D008297:Male; D008875:Middle Aged
D000900:Anti-Bacterial Agents; D002442:Ceftazidime