Making strides in peptide-based therapeutics.
In a recent report published in PNAS, Gellman and coworkers describe the design, characterization, and potent activity of alpha/beta-peptides that mimic a long alpha helix involved in HIV viral entry.
Guarracino
Danielle A
DA
Department of Chemistry, New York University, 100 Washington Square East, New York, NY 10003, USA.
Arora
Paramjit S
PS
D015700:HIV Envelope Protein gp41 / Q000037:antagonists & inhibitors / Q000378:metabolism; D023581:HIV Fusion Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D010456:Peptides, Cyclic / Q000737:chemistry / Q000494:pharmacology*; D054730:Protein Interaction Domains and Motifs; D017433:Protein Structure, Secondary
D015700:HIV Envelope Protein gp41; D023581:HIV Fusion Inhibitors; D010456:Peptides, Cyclic