Anaesthetic and cardiorespiratory effects of propofol at 10% for induction and 1% for maintenance of anaesthesia in horses.
BACKGROUND
Studies have demonstrated the clinical usefulness of propofol for anaesthesia in horses but the use of a concentrated solution requires further investigation.


OBJECTIVE
To determine the anaesthetic and cardiorespiratory responses to a bolus injection of 10% propofol solution in mature horses.


METHODS
Three randomised crossover experimental trials were completed. Trial 1: 6 horses were selected randomly to receive 10% propofol (2, 4 or 8 mg/kg bwt i.v.). Trial 2: 6 horses received 1.1 mg/kg bwt i.v. xylazine before being assigned at random to receive one of 5 different doses (1-5 mg/kg bwt) of 10% propofol. Trial 3: 6 horses were sedated with xylazine (0.5 mg/kg bwt, i.v.) and assigned randomly to receive 10% propofol (3, 4 or 5 mg/kg bwt, i.v.); anaesthesia was maintained for 60 min using an infusion of 1% propofol (0.2-0.4 mg/kg bwt/min). Cardiorespiratory data, the quality of anaesthesia, and times for induction, maintenance and recovery from anaesthesia and the number of attempts to stand were recorded.


RESULTS
Trial 1 was terminated after 2 horses had received each dose of 10% propofol. The quality of induction, anaesthesia and recovery from anaesthesia was judged to be unsatisfactory. Trial 2: 3 horses administered 1 mg/kg bwt and one administered 2 mg/kg bwt were not considered to be anaesthetised. Horses administered 3-5 mg/kg bwt i.v. propofol were anaesthetised for periods ranging from approximately 10-25 min. The PaO2 was significantly decreased in horses administered 3-5 mg/kg bwt i.v. propofol. Trial 3: The quality of induction and recovery from anaesthesia were judged to be acceptable in all horses. Heart rate and rhythm, and arterial blood pressure were unchanged or decreased slightly during propofol infusion period.


CONCLUSIONS
Anaesthesia can be induced with a 10% propofol solution and maintained with a 1% propofol solution in horses administered xylazine as preanaesthetic medication. Hypoventilation and hypoxaemia may occur following administration to mature horses.


CONCLUSIONS
Adequate preanaesthetic sedation and oxygen supplementation are required in horses anaesthetised with propofol.
Veterinary Clinical Pharmacology Consulting Services, 338 W 7th Ave., Columbus, Ohio 43210, USA.
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Muir
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Lerche
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Erichson
D000762:Anesthesia Recovery Period; D000768:Anesthesia, General / Q000662:veterinary; D018681:Anesthetics, General / Q000008:administration & dosage* / Q000494:pharmacology*; D000818:Animals; D018592:Cross-Over Studies; D004305:Dose-Response Relationship, Drug; D005260:Female; D006736:Horses; D008297:Male; D015742:Propofol / Q000008:administration & dosage* / Q000494:pharmacology*
D018681:Anesthetics, General; D015742:Propofol