Parathyroid hormone (1-84) and teriparatide in the treatment of postmenopausal osteoporosis.
Osteoporosis-related fractures are a major public health problem worldwide. Antiresorptive drugs, which work principally by suppressing bone resorption, are the established therapeutic approach for the prevention of fragility fractures in patients with osteoporosis. Parathyroid hormone and its analogs represent a new class of agents with anabolic effects on the skeleton. The results of double-blind, randomized, placebo-controlled trials have shown that both the full length, 84 amino acid parathyroid hormone and teriparatide, the parathyroid hormone fragment (1-34) increase bone mineral density and reduce the risk of fracture when administered intermittently to postmenopausal osteoporotic women. Therefore, these drugs should be considered an alternative therapy in postmenopausal osteoporosis.
Bogado
César E
CE
Instituto de Investigaciones Metabólicas, Libertad 836, C1012 Buenos Aires, Argentina. bogadoc@idim.com.ar.
Massari
Fabio E
FE
Zanchetta
José R
JR