Resolution of late sirolimus-eluting stent thrombosis after tirofiban treatment.
A 40-year-old male patient was admitted to the hospital with acute chest pain. A sirolimus-eluting stent (SES) had been deployed to the circumflex artery (Cx) 3 years before. Now, inferior ST-segment elevations were observed and coronary angiography revealed stent thrombosis with distal TIMI 3 grade flow in the Cx. Tirofiban infusion was administered and the control angiography 2 days later revealed complete resolution of the thrombus. Stent thrombosis is a rare but usually poor prognostic event, frequently associated with large myocardial infarction (MI) or death. Very late drug-eluting stent (DES) thrombosis remains a major problem of interventional cardiology due to its high morbidity and mortality. We conclude that tirofiban may be an interesting candidate drug for treatment of very late stent thrombosis.
Department of Cardiology, Ministry of Health, Dişkapi Yildirim Beyazit Research and Education Hospital, Ankara, Turkey. ozlemkarakurt55@yahoo.com
Ozlem
O
Karakurt
Goksel
G
Cagirci
Harun
H
Kilic
Ramazan
R
Akdemir
D000328:Adult; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects / Q000295:instrumentation; D002317:Cardiovascular Agents / Q000008:administration & dosage*; D017023:Coronary Angiography; D003326:Coronary Circulation; D003328:Coronary Thrombosis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D054855:Drug-Eluting Stents; D004562:Electrocardiography; D005343:Fibrinolytic Agents / Q000008:administration & dosage*; D006801:Humans; D007261:Infusions, Intra-Arterial; D008297:Male; D020123:Sirolimus / Q000008:administration & dosage*; D015912:Thrombolytic Therapy; D000077466:Tirofiban; D016896:Treatment Outcome; D014443:Tyrosine / Q000008:administration & dosage / Q000031:analogs & derivatives*
D002317:Cardiovascular Agents; D005343:Fibrinolytic Agents; D014443:Tyrosine; D000077466:Tirofiban; D020123:Sirolimus