A cut above the other caspases.
In this issue of Molecular Cell, Bouchier-Hayes et al. (2009) develop a novel approach to visualizing caspase-2 activation in real time, enabling resolution of several controversies surrounding the position of this enzyme in apoptotic signaling cascades.
Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Box 3813, C370 LSRC, Durham, NC 27710, USA.
Joshua L
JL
Andersen
Sally
S
Kornbluth
D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D053477:Apoptotic Protease-Activating Factor 1 / Q000378:metabolism; D001426:Bacterial Proteins / Q000235:genetics; D015374:Biosensing Techniques; D053420:CRADD Signaling Adaptor Protein / Q000378:metabolism; D053143:Caspase 2 / Q000235:genetics / Q000378:metabolism*; D003593:Cytoplasm / Q000201:enzymology*; D004249:DNA Damage; D004268:DNA-Binding Proteins / Q000378:metabolism; D004789:Enzyme Activation; D053200:Fas-Associated Death Domain Protein / Q000378:metabolism; D018841:HSP90 Heat-Shock Proteins / Q000378:metabolism; D000076249:Heat Shock Transcription Factors; D006358:Hot Temperature; D006801:Humans; D007700:Kinetics; D008164:Luminescent Proteins / Q000235:genetics; D051379:Mice; D018613:Microscopy, Confocal; D055503:Protein Multimerization; D011993:Recombinant Fusion Proteins / Q000378:metabolism; D015398:Signal Transduction; D013312:Stress, Physiological; D014157:Transcription Factors / Q000378:metabolism; D050257:Tubulin Modulators / Q000494:pharmacology
D053477:Apoptotic Protease-Activating Factor 1; D001426:Bacterial Proteins; D053420:CRADD Signaling Adaptor Protein; C484481:Cradd protein, mouse; D004268:DNA-Binding Proteins; D053200:Fas-Associated Death Domain Protein; D018841:HSP90 Heat-Shock Proteins; C533585:HSP90AA2P protein, human; D000076249:Heat Shock Transcription Factors; C490017:Hsf1 protein, mouse; D008164:Luminescent Proteins; D011993:Recombinant Fusion Proteins; D014157:Transcription Factors; D050257:Tubulin Modulators; C054562:yellow fluorescent protein, Bacteria; D053143:Caspase 2