Radical carbonylations using a continuous microflow system.
Radical-based carbonylation reactions of alkyl halides were conducted in a microflow reactor under pressurized carbon monoxide gas. Good to excellent yields of carbonylated products were obtained via radical formylation, carbonylative cyclization and three-component coupling reactions, using tributyltin hydride or TTMSS as a radical mediator.
Department of Chemistry, Graduate School of Science, Osaka Prefecture University, Sakai, Osaka 599-8531, Japan.
Takahide
T
Fukuyama
Md Taifur
MT
Rahman
Naoya
N
Kamata
Ilhyong
I
Ryu