Disseminated Geotrichum candidum infection in a patient with relapsed acute myelogenous leukemia following allogeneic stem cell transplantation and review of the literature.
We describe a woman with relapsed acute myelogenous leukemia after allogeneic stem cell transplantation who developed disseminated Geotrichum candidum infection during chemotherapy-induced neutropenia. The isolate was susceptible to voriconazole, amphotericin B, and micafungin in vitro. We review the literature regarding invasive infections with G. candidum, which predominantly affect immunocompromised hosts, and discuss potential therapies for this rare pathogen.
Division of Infectious Diseases, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA. thenrich@partners.org
T J
TJ
Henrich
F M
FM
Marty
D A
DA
Milner
A R
AR
Thorner
D000935:Antifungal Agents / Q000494:pharmacology / Q000627:therapeutic use; D002405:Catheterization, Central Venous / Q000009:adverse effects; D005260:Female; D005847:Geotrichosis / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D005848:Geotrichum / Q000145:classification / Q000187:drug effects; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications*; D008875:Middle Aged; D012008:Recurrence; D033581:Stem Cell Transplantation / Q000009:adverse effects*; D014184:Transplantation, Homologous / Q000009:adverse effects*
D000935:Antifungal Agents