Neural correlates of memory in depression measured by brain perfusion SPECT at rest.
OBJECTIVE
Brain metabolism activated studies have indicated associations between memory and the anterior cingulate cortex and hippocampus in patients with depression. The aim of the present study was therefore to investigate memory function, measured as performance on the Wechsler Memory Scale-Revised (WMS-R), and its relationship to brain perfusion using single-photon emission computed tomography (SPECT) at rest in patients with depression.


METHODS
The Hamilton Rating Scale for Depression (HAMD) and WMS-R were measured for 17 patients with depression by an independent clinical evaluation team. Voxel-based correlation analyses were performed with statistical parametric mapping at an extent threshold of 200 voxels. Associations were controlled for state and trait factors.


RESULTS
WMS-R measurements of verbal, visual, and general memory were inversely correlated with brain perfusion in the right anterior cingulate cortex, left premotor cortices, and both regions, respectively. The HAMD directly correlated with brain perfusion in the right anterior cingulate cortex.


CONCLUSIONS
Brain perfusion SPECT measurements of the anterior cingulate cortex at rest were associated with the severity of depression and immediate memory scores measured with the WMS-R.
Department of Psychiatry and Cognitive Behavioral Medicine, Nagoya University, Graduate School of Medical Sciences, Nagoya, Japan. azma@med.nagoya-cu.ac.jp
Hideki
H
Azuma
Kazuhisa
K
Segawa
Shutaro
S
Nakaaki
Yoshie
Y
Murata
Kazunori
K
Kawakami
Junko
J
Tohyama
Tetsuya
T
Iidaka
Yoshihiro
Y
Shinagawa
Yumi
Y
Nakano
Atsurou
A
Yamada
Norio
N
Watanabe
Jin
J
Hongo
Tatsuo
T
Akechi
Toshi A
TA
Furukawa
D001921:Brain / Q000098:blood supply / Q000000981:diagnostic imaging / Q000503:physiopathology*; D001931:Brain Mapping; D003865:Major Depressive Disorder / Q000097:blood / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005260:Female; D006179:Gyrus Cinguli / Q000098:blood supply / Q000000981:diagnostic imaging / Q000503:physiopathology; D006624:Hippocampus / Q000098:blood supply / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D008297:Male; D008568:Memory / Q000502:physiology*; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012720:Severity of Illness Index; D015899:Tomography, Emission-Computed, Single-Photon