[Correlation between carbamazepine serum level and clinical condition of acute poisoned patient].
The aim of our study was to find out the relationship between the serum CBZ level and the clinical symptoms of acute intoxication. The research was conducted on 130 patients including 64 females and 66 males, aged from 14 to 59 years. We noted 65 cases of acute CBZ intoxication and 65 cases of mixed intoxications. In 115 patients the CBZ plasma level was higher than therapeutic range. Acute pulmonary failure was observed in 3 persons.


CONCLUSIONS
1. Positive correlation has been found at the serum CBZ concentrations and systolic blood pressure and pulse. 2. We failed to find any significant correlation between CBZ plasma level and the remaining parameters. 3. The heavier course of poisoning was not affirmed in the case of mixed intoxication in comparison to poisonings with only CBZ. 4. In persons treated with CBZ earlier, the course of poisoning was less severe.
Katedra i Zakład Farmakologii Doświadczalnej i Klinicznej, Warszawski Uniwersytet Medyczny. annastaniszewska@poczta.fm
Anna
A
Staniszewska
Piotr
P
Burda
Wojciech
W
Waldman
Jacek Sein
JS
Anand
D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000097:blood* / Q000506:poisoning*; D002220:Carbamazepine / Q000097:blood* / Q000506:poisoning*; D015984:Causality; D015897:Comorbidity; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011041:Poisoning / Q000097:blood* / Q000175:diagnosis* / Q000453:epidemiology; D011044:Poland / Q000453:epidemiology; D012131:Respiratory Insufficiency / Q000139:chemically induced / Q000453:epidemiology; D017678:Sex Distribution; D055815:Young Adult
D000927:Anticonvulsants; D002220:Carbamazepine