Organizing pneumonia with an enlarging tumor-like lesion: immunohistochemical study.
An 86-year-old woman was transferred to our department for investigation of an abnormal enlarging pulmonary shadow with vascular convergence. She had no respiratory symptoms or laboratory data suggesting inflammatory disease. A pulmonary wedge resection was performed under video-assisted thoracic surgery. Pathology examination revealed that the tumor was organizing pneumonia and was composed of fibroblast-like spindle cells, macrophages, lymphoplasma cells, and collagen fibers. Immunohistochemical study revealed that the lesion was in the proliferative state with the relatively more Ki-67-positive fibroblast-like spindle cells. When a surgical resection is necessary for an enlarging abnormal pulmonary mass without any systemic inflammatory reaction or respiratory symptoms, a less invasive approach should be selected.
Department of Thoracic Surgery, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Ishikawa, 920-0293, Japan. sagawam@kanazawa-med.ac.jp
Motoyasu
M
Sagawa
Yoshimichi
Y
Ueda
Hiroshi
H
Sakuma
Yutaka
Y
Yoshimitsu
Fujitsugu
F
Matsubara
Tsutomu
T
Sakuma
D000369:Aged, 80 and over; D000941:Antigens / Q000032:analysis*; D015415:Biomarkers / Q000032:analysis; D017252:CD3 Complex / Q000032:analysis; D015704:CD4 Antigens / Q000032:analysis; D051925:CD79 Antigens / Q000032:analysis; D016827:CD8 Antigens / Q000032:analysis; D049109:Cell Proliferation; D018549:Cryptogenic Organizing Pneumonia / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000032:analysis; D008168:Lung / Q000276:immunology* / Q000473:pathology / Q000601:surgery; D011013:Pneumonectomy / Q000379:methods; D011237:Predictive Value of Tests; D020775:Thoracic Surgery, Video-Assisted; D013908:Thoracotomy; D014057:Tomography, X-Ray Computed
D000941:Antigens; D015415:Biomarkers; D017252:CD3 Complex; D015704:CD4 Antigens; D051925:CD79 Antigens; C497881:CD79A protein, human; D016827:CD8 Antigens; D019394:Ki-67 Antigen