[Updates on ossification of posterior longitudinal ligament. Ossification front of posterior longitudinal ligament and cellular biological assessment of chronic mechanical compressed spinal cord].
Mechanisms of ossification processes, pathological changes, and treatment/assessment of myelopathy symptoms because of ossification of the posterior longitudinal ligament (OPLL) remain obscure. Enchondral ossification process of OPLL was closely associated with degenerative changes of elastic fibers and cartilage formation, together with the appearance of metaplastic hypertrophic cartilage cells and neovascularization. There are differences in expression degrees of cytokines and transcription factors between mixed and localized OPLL. While the chronic compressed spinal cord may have plasticity ; the use of stem cell implants, supplementation of neurotrophic factors, in addition to surgical treatment, may bring a better clinical outcome,encouraging the development of these basic research studies. Assessment using new imaging techniques needs to determine the affected level and judge the severity of symptoms.
Uchida
Kenzo
K
Department fo Orthopaedics Surgery, Faculty of Medical Sciences, University of Fukui.
Nakajima
Hideaki
H
Yayama
Takafumi
T
Sato
Ryuichiro
R
Baba
Hisatoshi
H
D000818:Animals; D017209:Apoptosis; D055396:Bone Morphogenetic Protein 2 / Q000502:physiology; D002454:Cell Differentiation; D019902:Chondrocytes / Q000166:cytology / Q000473:pathology; D002908:Chronic Disease; D003952:Diagnostic Imaging; D006801:Humans; D009416:Nerve Regeneration; D009473:Neuronal Plasticity; D017887:Ossification of Posterior Longitudinal Ligament / Q000150:complications* / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D044968:Regenerative Medicine; D012720:Severity of Illness Index; D013116:Spinal Cord / Q000502:physiology; D013117:Spinal Cord Compression / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology* / Q000628:therapy; D016212:Transforming Growth Factor beta / Q000502:physiology
D055396:Bone Morphogenetic Protein 2; D016212:Transforming Growth Factor beta