2-Hydroxydiplopterol, a new cytotoxic pentacyclic triterpenoid from the halotolerant fungus Aspergillus variecolor B-17.
A new hopane type pentacyclic triterpenoid, 2-hydroxydiplopterol (1) has been isolated from the metabolites produced by the halotolerant fungal strain Aspergillus variecolor B-17. The structure of 1 was determined by spectroscopic methods and single crystal X-Ray diffraction analysis. 2-Hydroxydiplopterol (1) exhibited cytotoxicity against K562 cells with an IC50 value of 22 microM.
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
Wen-Liang
WL
Wang
Pei-Pei
PP
Liu
Ya-Peng
YP
Zhang
Jing
J
Li
Hong-Wen
HW
Tao
Qian-Qun
QQ
Gu
Wei-Ming
WM
Zhu
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001230:Aspergillus / Q000378:metabolism*; D018360:Crystallography, X-Ray; D006801:Humans; D020014:K562 Cells; D007941:Leukemia P388 / Q000188:drug therapy; D051379:Mice; D053978:Pentacyclic Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
D000970:Antineoplastic Agents; D053978:Pentacyclic Triterpenes