[The role of serum leptin in infants with wheezing after respiratory syncytial virus infected].
OBJECTIVE
To determine the role of serum leptin in infants with wheezing after respiratory syncytial virus infected.


METHODS
43 infants infected with RSV were given blood samples to detect leptin concentration with radioimmunoassays (RIA) within 24 hours after admission into hospital, discharged and 12 weeks later. Then, they were followed up for 2 years. 10 healthy children of the same age served as controls.


RESULTS
41.9% infants developed asthma after infected with RSV. Compared to control group, the serum level of leptin in the asthma group and non-asthma group were significantly higher before treatment (t = 3.41 and 2.64 respectively, P < 0.05). When they were discharged, the serum level of leptin in the asthma group was significantly higher than that in non-asthma group and control group (t = 5.74 and 6.23, respectively, P < 0.05). 12 weeks later, the serum level of leptin in the asthma group was still significantly higher than that in non-asthma group and control group (t = 6.32 and 6.11, respectively, P < 0.05), but there were no difference between non-asthma group and control group (t = 0.81, P > 0.05).


CONCLUSIONS
The serum level of leptin in infants with asthma after RSV infected was higher than that in healthy and non-asthma children. Persistent higher level of leptin may play an important role in infants with asthma after RSV infected.
Chen
Zhuang-Gui
ZG
Department of Pediatrics, the 3rd Hospital affiliated Sun Yet-sen University, Guangzhou 510630, China.
Li
Ming
M
Ji
Jing-Zhi
JZ
Zhang
Yong
Y
Chen
Hong
H
Chen
Yan-Feng
YF
Chen
Fen-Hua
FH
Deng
Li
L
D001249:Asthma / Q000097:blood* / Q000276:immunology / Q000821:virology; D016022:Case-Control Studies; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D020738:Leptin / Q000097:blood* / Q000276:immunology; D008297:Male; D012135:Respiratory Sounds / Q000276:immunology; D018357:Respiratory Syncytial Virus Infections / Q000097:blood* / Q000276:immunology / Q000821:virology; D012136:Respiratory Syncytial Viruses / Q000276:immunology / Q000502:physiology*
D020738:Leptin