Acute suppression of bone turnover with calcium infusion in persons with spinal cord injury.
BACKGROUND
Some people with chronic spinal cord injury (SCI) have low vitamin D levels and secondary hyperparathyroidism.


OBJECTIVE
To determine whether, and to what extent, an acute calcium infusion decreased levels of N-telopeptide (NTx), a marker of osteoclastic activity, in individuals with chronic SCI.


METHODS
Case series.


METHODS
Eight men with chronic SCI. A relatively low serum 25 hydroxyvitamin D concentration (25[OH]D < or =20 ng/mL) and/or a high parathyroid hormone (PTH) (>55 pg/mL) was a prerequisite for study inclusion.


METHODS
Calcium gluconate bolus 0.025 mmol elemental calcium/kg over 20 minutes followed by a constant infusion of 0.025 mmol/kg per hour for 6 hours was infused; blood samples were collected every 2 hours for measurement of serum total calcium, creatinine, NTx, and PTH.


RESULTS
All results are expressed as means (+/- SDs). Baseline serum 25-hydroxyvitamin D level was 14.5 +/- 3.5 ng/mL (range: 10.2-19.6 ng/mL); PTH, 70 +/- 25 pg/mL (range: 37-100 pg/mL); and NTx, 21 +/- 7 nM bone collagen equivalents (BCE) (range: 14-34 nM). At 2, 4, and 6 hours after the calcium infusion, serum calcium rose from 9.3 +/- 0.2 to 10.8 +/- 0.9, 10.5 +/- 0.8, and 10.6 +/- 0.6 mg/d; PTH was suppressed from 70 +/- 25 pg/mL to 18 +/- 12, 16 +/- 9, and 15 +/- 9 pg/mL, respectively; NTx fell from 21 +/- 8 nM BCE to 17 +/- 5, 12 +/- 4, and 12 +/- 3 nM BCE, respectively.


CONCLUSIONS
Serum NTx is a marker for bone collagen catabolism, and its reduction suggests that bone turnover was decreased. A relative deficiency of vitamin D associated with chronically elevated levels of PTH would be expected to increase bone turnover and to worsen the bone loss associated with immobilization.
Bauman
William A
WA
Veterans Affairs Rehabilitation Research and Development Center of Excellence, USA. william.bauman@va.gov
Zhang
Run-Lin
RL
Morrison
Nancy
N
Spungen
Ann M
AM
D000328:Adult; D000704:Analysis of Variance; D002118:Calcium / Q000097:blood; D024042:Collagen Type I / Q000097:blood; D006801:Humans; D008297:Male; D009942:Organometallic Compounds / Q000008:administration & dosage*; D010281:Parathyroid Hormone / Q000097:blood; D010455:Peptides / Q000097:blood; D013119:Spinal Cord Injuries / Q000097:blood* / Q000188:drug therapy*; D013997:Time Factors; D014312:Trisaccharides / Q000008:administration & dosage*; D014807:Vitamin D / Q000031:analogs & derivatives / Q000097:blood; D055815:Young Adult
D024042:Collagen Type I; D009942:Organometallic Compounds; D010281:Parathyroid Hormone; D010455:Peptides; D014312:Trisaccharides; C052929:collagen type I trimeric cross-linked peptide; D014807:Vitamin D; C042131:calcium glubionate; C104450:25-hydroxyvitamin D; D002118:Calcium