Synthesis and cytotoxicity of novel hexahydrothienocycloheptapyridazinone derivatives.
Designed as a new group of tricyclic molecules containing the thienocycloheptapyridazinone ring system, a number of 2N-substituted-hexahydrothienocycloheptapyridazinone derivatives were synthesized and their biological activity evaluated. Among the synthesized compounds, derivatives 7d and 7h were found to possess cytotoxic activity against non-small cell lung cancer and central nervous system cancer cell lines, respectively.
Pau
Amedeo
A
Dipartimento Farmaco Chimico Tossicologico,Università di Sassari, Via Muroni 23/A, 07100 Sassari, Italy. pau@uniss.it
Murineddu
Gabriele
G
Asproni
Battistina
B
Murruzzu
Caterina
C
Grella
Giuseppe E
GE
Pinna
Gérard A
GA
Curzu
Maria M
MM
Marchesi
Irene
I
Bagella
Luigi
L
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D011724:Pyridazines / Q000138:chemical synthesis* / Q000494:pharmacology*; D013876:Thiophenes / Q000138:chemical synthesis* / Q000494:pharmacology*
D000970:Antineoplastic Agents; D011724:Pyridazines; D013876:Thiophenes