Acetylcholinesterase and HHV-8 in squamous cell carcinoma and retinoblastoma.
Acetylcholinesterase (AChE) and human herpesvirus type 8 (HHV-8) antigens were studied in tissue sections from 56 squamous cell carcinomas (SCC) and five retinoblastomas (Rb). Approximately 62.5% of SCC and 80% of Rb showed positive staining for AChE. AChE staining in tumors was much higher than in normal control tissue. However, only 21.4% of SCC and 60% of Rb contained HHV-8 antigens. Of the 56 SCC, 17.9% were positive for both AChE and HHV-8 antigens, whereas 60% Rb were positive for both markers. The co-existence of AChE and HHV-8 antigens may play a role in the development of SCC and Rb. A possible mechanism for the development of these tumors is discussed.
Qavi
Hamida
H
Department of Natural Sciences, University of Houston, Houston, Texas, USA. HamidaQavi@sbcglobal.net; Qavih@uhd.edu
Al-Rajhi
Ali A
AA
D000110:Acetylcholinesterase / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000473:pathology* / Q000821:virology; D015897:Comorbidity; D006566:Herpesviridae Infections / Q000150:complications / Q000453:epidemiology / Q000473:pathology*; D019288:Herpesvirus 8, Human / Q000302:isolation & purification* / Q000502:physiology; D006801:Humans; D007124:Immunoenzyme Techniques; D019572:Retinal Neoplasms / Q000453:epidemiology / Q000473:pathology* / Q000821:virology; D012175:Retinoblastoma / Q000453:epidemiology / Q000473:pathology* / Q000821:virology; D012529:Saudi Arabia / Q000453:epidemiology; D016036:Seroepidemiologic Studies
D000110:Acetylcholinesterase