[Investigating genotype of HCV distribution among residents in a "blood donation" village in Hebei Province].
OBJECTIVE
To investigate genotype of HCV infection among residents in a rural village, Hebei Province.


METHODS
Blood samples of the 520 residents were collected, and C/E1 of HCV genome of the 483 samples were obtained by RT-PCR amplifying, and the gene sequences were analyzed and the polygenetic tree were drawn by the software Mega 4.0.


RESULTS
In 483 subjects, HCV-RNA positive objectives are 70, positive prevalence is 14.5%, genotyping for all the samples successfully, including genotypes 1b and 2a, which are 36 (51.4%), 34 (48.6%) respectively.


CONCLUSIONS
HCV RNA positive rate is 14.5%, which is higher than general people. Subtypes 1b and 2a seemed to be the dominant genotypes of HCV in Zhao county area of Hebei Province.
Hebei Medical University, Shijiazhuang 050017, China.
Chang-Hong
CH
Huang
Ji-Kun
JK
Zhou
Li
L
Liu
Rong-Men
RM
Jiang
Yan-Qiang
YQ
Cao
Zhen-Yun
ZY
Mu
Yong
Y
Zhang
D000293:Adolescent; D000328:Adult; D001782:Blood Donors; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D005260:Female; D005838:Genotype; D016174:Hepacivirus / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D006526:Hepatitis C / Q000453:epidemiology* / Q000821:virology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D010802:Phylogeny; D055815:Young Adult