A genome wide association analysis in the GENDER study.
Percutaneous coronary intervention (PCI) has become an effective therapy to treat coronary artery diseases. However, one of the major drawbacks of PCI is the occurrence of restenosis in 8 to 40% of all treated patients. The GENetic Determinants of Restenosis (GENDER) project was designed to study the association between genetic polymorphisims and clinical restenosis. The discovery of genetic variants associated to the occurrence of restenosis after PCI may provide a more tailored therapy and may serve as rationale for new antirestenotic therapies. So far, several candidate gene approaches had already been performed in the GENDER samples but a Genome Wide Association Scan (GWAS) was still lacking. Here, we present preliminary results from the GWAS we are currently carrying out in the GENDER population. (Neth Heart J 2009;17:262-4.).
Departments of Human Genetics and Cardiology, Leiden University Medical Center, Leiden, Durrer Center for Cardiogenetic Research, Amsterdam and the Interuniversity Cardiology Institute (ICIN), Utrecht, the Netherlands.
M L
ML
Sampietro
D
D
Pons
P
P
de Knijff
P E
PE
Slagboom
A
A
Zwinderman
J W
JW
Jukema