Crohn's disease complicated by primary gastrointestinal Hodgkin's lymphoma presenting with small bowel perforation.
An increased incidence of non-Hodgkin's lymphoma has been reported in patients with inflammatory bowel disease, particularly in those receiving immunosuppressive therapy. Rare cases of Hodgkin;s lymphoma have been reported in a setting of inflammatory bowel disease. The mechanism underlying the apparent association is unclear, but alterations in immune surveillance could play a role. In this report we describe the clinicopathological features of primary gastrointestinal Hodgkin's lymphoma diagnosed in a patient with Crohn's ileocolitis who had been receiving therapy with immunomodulator and biologic therapies.
Castrellon
Aurelio
A
University of Miami, Miami Veteran Administration Hospital, Miami, FL, USA. aureliocastrellon@yahoo.com
Feldman
Paul Andrew
PA
Suarez
Miguel
M
Spector
Seth
S
Chua
Lucy
L
Byrnes
John
J
D000368:Aged; D003424:Crohn Disease / Q000150:complications*; D005770:Gastrointestinal Neoplasms / Q000209:etiology*; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006689:Hodgkin Disease / Q000209:etiology*; D006801:Humans; D007077:Ileal Diseases / Q000209:etiology*; D007416:Intestinal Perforation / Q000209:etiology*; D008297:Male