The variant red coat colour phenotype of Holstein cattle maps to BTA27.
The variant red phenotype in Holstein cattle is indistinguishable from the traditional e/e recessive red phenotype caused by a mutation in melanocortin 1 receptor, but is inherited as a dominant trait in relation to black. Co-segregation analysis in four half-sib families segregating for variant red was conducted, excluding melanocortin 1 receptor, agouti signalling protein, attractin and melatonin receptor 1A as causative genes. However, variant red co-segregated with markers in a region of BTA27 that includes beta-defensin 103 (DEFB103). Two newly identified microsatellites and 5 SNPs 5' of DEFB103 were used for linkage mapping in four segregating families (LOD = 3.26). One haplotype was inherited in VR cattle in a 6-generation pedigree.
Dreger
D L
DL
Department of Animal and Poultry Science, University of Saskatchewan, Saskatoon, Canada.
Schmutz
S M
SM
D000818:Animals; D002417:Cattle / Q000033:anatomy & histology* / Q000235:genetics*; D033481:Chromosomes, Mammalian; D005260:Female; D008297:Male; D018895:Microsatellite Repeats; D010375:Pedigree; D012880:Skin Pigmentation; D023083:beta-Defensins / Q000235:genetics
D023083:beta-Defensins