Cell-context specific role of the E2F/Rb pathway in development and disease.
Development of the central nervous system (CNS) requires the generation of neuronal and glial cell subtypes in appropriate numbers, and this demands the careful coordination of cell-cycle exit, survival, and differentiation. The E2F/Rb pathway is critical for cell-cycle regulation and also modulates survival and differentiation of distinct cell types in the developing and adult CNS. In this review, we first present the specific temporal patterns of expression of the E2F and Rb family members during CNS development and then discuss the genetic ablation of single or multiple members of these two families. Overall, the available data suggest a time-dependent and cell-context specific role of E2F and Rb family members in the developing and adult CNS.
Department of Neuroscience and Genetics and Genomics, Mount Sinai School of Medicine, New York, New York 10029, USA.
Victoria A
VA
Swiss
Patrizia
P
Casaccia
D000818:Animals; D002490:Central Nervous System / Q000254:growth & development* / Q000378:metabolism*; D002493:Central Nervous System Diseases / Q000378:metabolism*; D050684:E2F Transcription Factors / Q000378:metabolism*; D006801:Humans; D016160:Retinoblastoma Protein / Q000378:metabolism*; D015398:Signal Transduction
D050684:E2F Transcription Factors; D016160:Retinoblastoma Protein