Resting our cortices by going DOWN to sleep.
In this issue of Neuron, Vyazovskiy et al. reports on progressive changes in cortical unit activity within extended wakefulness and within extended sleep paralleling changes in EEG slow-wave sleep activity. Sleep debt may be integrated at the level of individual cortical neurons, providing support for the synaptic homeostasis theory.
Stanford University Center for Narcolepsy, Palo Alto, CA 94304-5742, USA. mignot@stanford.edu
Emmanuel
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Mignot
John R
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Huguenard
D000200:Action Potentials / Q000502:physiology; D000818:Animals; D002540:Cerebral Cortex / Q000166:cytology* / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D009474:Neurons / Q000502:physiology*; D051381:Rats; D012146:Rest / Q000502:physiology*; D012890:Sleep / Q000502:physiology*