The effect of a total colectomy on the motor inhibition of the upper gut induced by intraileal stimuli in conscious dogs.
OBJECTIVE
The administration of stimuli to the ileum inhibits upper gastrointestinal motility. The aim of this study was to determine whether a total colectomy can alter this motor inhibitory effect.


METHODS
Beagle dogs were each equipped with four strain gauge force transducers on the upper gastrointestinal tract. The infusion of nutrients (saline as placebo control, oleate, butyrate, and glucose) began 90 min after feeding and continued for 30 min via a silicone catheter placed in the ileal lumen. Capsaicin (10 mg) was injected into the ileum as a bolus. All of the dogs underwent a relaparotomy and a total colectomy, and the same experiments were performed on all dogs.


RESULTS
Before performing a colectomy, the oleate, the glucose, and the capsaicin were each found to inhibit the postprandial upper gastrointestinal motility in comparison to the placebo control (P < 0.05). The butyrate had no inhibitory effect. After a total colectomy, the inhibition of upper gastrointestinal motility was observed after the intraileal infusion of the oleate and the capsaicin (P < 0.05). The motor inhibitory response to the intraileal glucose was delayed after a total colectomy, and a reduction of the motility index was not observed in the gastric antrum and the duodenum because of this delay. However, a significant reduction in the motility index was observed in the jejunum.


CONCLUSIONS
The intraileal stimuli-induced motor inhibition decreased after a total colectomy after the administration of glucose, but not after the administration of either oleate or capsaicin.
Nagao
Munenori
M
Division of Biological Regulation and Oncology, Department of Surgery, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan.
Shibata
Chikashi
C
Funayama
Yuji
Y
Fukushima
Kouhei
K
Miura
Koh
K
Ogawa
Hitoshi
H
Ueno
Tatsuya
T
Kudoh
Katsuyoshi
K
Unno
Michiaki
M
Sasaki
Iwao
I
D000818:Animals; D002087:Butyrates / Q000008:administration & dosage; D002211:Capsaicin / Q000008:administration & dosage; D003082:Colectomy; D003243:Consciousness; D004285:Dogs; D005765:Gastrointestinal Agents / Q000008:administration & dosage*; D005769:Gastrointestinal Motility / Q000187:drug effects*; D005772:Gastrointestinal Transit; D005947:Glucose / Q000008:administration & dosage; D007082:Ileum / Q000294:innervation*; D019301:Oleic Acid / Q000008:administration & dosage
D002087:Butyrates; D005765:Gastrointestinal Agents; D019301:Oleic Acid; D005947:Glucose; D002211:Capsaicin