Bridge-1 is expressed in human granulosa cells and is involved in the activin A signaling cascade.
The present study investigates the expression of the coactivator Bridge-1 in the human ovary and its role in activin A signaling in the human granulosa cell line HGL-5. Expression of Bridge-1 can be stimulated by activin A, an important factor for follicle maturation, matching the increase of Smad 2, 3, and 4; treatment with Bridge-1-small interfering RNA is decreasing not only the expression of Bridge-1 but also the expression of Smad2, 3, and 4 in HGL-5 cells.
Constanze Banz, M.D., University of Schleswig-Holstein, Campus Lübeck, Department of Gynecology and Obstetrics, Ratzeburger Allee 160, 23538 Lübeck, Germany. banzcon@hotmail.com
Constanze
C
Banz
Birte
B
Münchow
Klaus
K
Diedrich
D028341:Activins / Q000494:pharmacology* / Q000502:physiology; D002460:Cell Line; D005260:Female; D005786:Gene Expression Regulation; D006107:Granulosa Cells / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism / Q000502:physiology*; D046988:Proteasome Endopeptidase Complex / Q000096:biosynthesis*; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology*; D051899:Smad2 Protein / Q000096:biosynthesis; D051900:Smad3 Protein / Q000096:biosynthesis; D051901:Smad4 Protein / Q000096:biosynthesis
D047908:Intracellular Signaling Peptides and Proteins; C114476:PSMD9 protein, human; D051899:Smad2 Protein; C497784:Smad2 protein, rat; D051900:Smad3 Protein; C497787:Smad3 protein, rat; D051901:Smad4 Protein; C490811:Smad4 protein, rat; C422405:activin A; D028341:Activins; D046988:Proteasome Endopeptidase Complex