[Effect of antipsychotic drugs on life quality of schizophrenic patients: one year follow-up study].
OBJECTIVE
To compare the effect of 7 antipsychotic drugs on the life quality of schizophrenia patients including chlorpromazine, sulpiride, clozapine, risperidone, olanzapine, quetiapine, and aripiprazole.


METHODS
A total of 1,227 stable schizophrenic patients within 5 years onset who took 1 of the 7 study medications as maintenance treatment were followed up for 1 year at 10 China sites. Patients were evaluated by the short form-36 health survey (SF-36) at the baseline and at the end of 1 year.


RESULTS
The life quality was improved obviously at the end of the follow-up. There was significant difference in body pain, vitality, and mental health (P<0.05) among these antipsychotic drugs.


CONCLUSIONS
All 7 antipsychotic drugs can improve the life quality of schizophrenia patients. Atypical antipsychotic drugs, especially olazapine and quetiapine, are superior to typical antipsychotic drugs in improving life quality.
Fang
Maosheng
M
Wuhan Mental Health Center, Wuhan, China.
Li
Lehua
L
Zhao
Jingping
J
Chen
Honghui
H
Ye
Meng
M
Guo
Xiaofeng
X
Lu
Zheng
Z
Sun
Xueli
X
Wang
Chuanyue
C
Xie
Shiping
S
Hu
Bin
B
Guo
Tiansheng
T
Ma
Cui
C
Wang
Bo
B
Lü
Luxian
L
Liu
Na
N
Deng
Hong
H
Chen
Qi
Q
Shang
Xiaofang
X
Gong
Fajin
F
Zhang
Xiyan
X
He
Xiaolin
X
Zhou
Jianchu
J
Zhang
Yingli
Y
D000293:Adolescent; D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001569:Benzodiazepines / Q000627:therapeutic use*; D003987:Dibenzothiazepines / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D000077152:Olanzapine; D011788:Quality of Life; D000069348:Quetiapine Fumarate; D012559:Schizophrenia / Q000188:drug therapy*; D011795:Surveys and Questionnaires; D055815:Young Adult
D014150:Antipsychotic Agents; D003987:Dibenzothiazepines; D001569:Benzodiazepines; D000069348:Quetiapine Fumarate; D000077152:Olanzapine