Dipyridodiazepinone derivatives; synthesis and anti HIV-1 activity.
Ten dipyridodiazepinone derivatives were synthesized and evaluated for their anti HIV-1 reverse transcriptase activity against wild-type and mutant type enzymes, K103N and Y181C. Two of them were found to be promising inhibitors for HIV-1 RT.
Khunnawutmanotham
Nisachon
N
Chulabhorn Research Institute, Vibhavadee-Rangsit Highway, Bangkok 10210, Thailand.
Chimnoi
Nitirat
N
Thitithanyanont
Arunee
A
Saparpakorn
Patchreenart
P
Choowongkomon
Kiattawee
K
Pungpo
Pornpan
P
Hannongbua
Supa
S
Techasakul
Supanna
S