Central nervous system involvement in CD4+/CD56+ hematodermic neoplasm: a report of two cases.
CD4+/CD56+ hematodermic neoplasm, formerly known as blastic NK-cell lymphoma, is an uncommon, aggressive non-Hodgkin's lymphoma with cutaneous, lymph node, and bone marrow involvement at presentation. The disease is characterized by early leukemic phase; however, central nervous system involvement is rarely reported. Herein we describe two cases of CD4+/CD56+ hematodermic neoplasm with meningeal manifestation. Microscopic analysis and flow cytometry of cerebrospinal fluid proved to be diagnostic; however, imaging studies were not informative. These observations call attention to the possibility of central nervous system involvement, which could be more common than expected previously. Authors recommend routine cerebrospinal fluid analysis and prophylactic intrathecal chemotherapy in patients with this highly aggressive disease.
Department of Dermatology, Venerology and Dermatooncology, Faculty of Medicine, Semmelweis University, Mária str. 41, 1085, Budapest, Hungary. dr.eros@citromail.hu
Nóra
N
Eros
Márta
M
Marschalkó
Katalin
K
Balassa
Bernadett
B
Hídvégi
József
J
Szakonyi
Sándor
S
Ilniczky
Katalin
K
Borka
Attila
A
Kovács
Gyula
G
Bottlik
Judit
J
Hársing
Judit
J
Csomor
Agota
A
Szepesi
András
A
Matolcsy
Sarolta
S
Kárpáti
Judit
J
Demeter
D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism / Q000473:pathology; D019002:CD56 Antigen / Q000378:metabolism; D002469:Cell Separation; D017809:Fatal Outcome; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D016130:Immunophenotyping; D054391:Lymphoma, Extranodal NK-T-Cell / Q000473:pathology* / Q000503:physiopathology* / Q000628:therapy; D008297:Male; D008577:Meningeal Neoplasms / Q000473:pathology* / Q000503:physiopathology* / Q000628:therapy
D000970:Antineoplastic Agents; D019002:CD56 Antigen