Another facet of ubiquitylation: death.
Ubiquitylation of caspase-8 by the Cullin3 E3 ligase allows its translocation to cytosolic aggregates in the cell by p62/sequestosome-1, increasing caspase-8 activation and thus leading to TRAIL-induced cell death.
Wong
W Wei-Lynn
WW
Department of Biochemistry, La Trobe University, Kingsbury Drive, Melbourne, VIC 3086, Australia. l.wong@latrobe.edu.au
Silke
John
J
D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism; D000818:Animals; D053181:Caspase 8 / Q000378:metabolism; D016923:Cell Death; D044842:Cullin Proteins / Q000378:metabolism; D006360:Heat-Shock Proteins / Q000378:metabolism; D051379:Mice; D000071456:Sequestosome-1 Protein; D053221:TNF-Related Apoptosis-Inducing Ligand / Q000378:metabolism; D054875:Ubiquitination
D048868:Adaptor Proteins, Signal Transducing; D044842:Cullin Proteins; D006360:Heat-Shock Proteins; D000071456:Sequestosome-1 Protein; C101343:Sqstm1 protein, mouse; D053221:TNF-Related Apoptosis-Inducing Ligand; D053181:Caspase 8