Elevated first-trimester uric acid concentrations are associated with the development of gestational diabetes.
OBJECTIVE
We sought to demonstrate that elevated first-trimester uric acid is associated with development of gestational diabetes mellitus (GDM).


METHODS
Uric acid was measured in 1570 plasma samples collected at mean gestational age of 8.9 +/- 2.5 weeks. The primary outcome was GDM, diagnosed by 3-hour glucose tolerance test using Carpenter and Coustan criteria or by a 1-hour value of > or =200 mg/dL. Logistic regression was performed, adjusting for relevant covariates.


RESULTS
Almost half (46.6%) of the women with GDM had first-trimester uric acid concentrations in the highest quartile (>3.57-8.30 mg/dL). Women with uric acid in the highest quartile had a 3.25-fold increased risk (95% confidence interval, 1.35-7.83) of developing GDM after adjustment for body mass index and age. This effect was concentration dependent as risk increased with increasing uric acid quartiles (P = .003).


CONCLUSIONS
First-trimester hyperuricemia is associated with an increased risk of developing GDM, independent of body mass index.
Laughon
S Katherine
SK
Department of Obstetrics, Gynecology and Reproductive Services, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. laughonsk@mail.nih.gov
Catov
Janet
J
Provins
Traci
T
Roberts
James M
JM
Gandley
Robin E
RE
D015992:Body Mass Index; D016640:Diabetes, Gestational / Q000097:blood* / Q000453:epidemiology; D005260:Female; D006801:Humans; D033461:Hyperuricemia / Q000453:epidemiology; D007333:Insulin Resistance / Q000502:physiology; D016015:Logistic Models; D011247:Pregnancy; D011261:Pregnancy Trimester, First / Q000097:blood*; D012372:ROC Curve; D014527:Uric Acid / Q000097:blood*
D014527:Uric Acid