Antibacterial activity of aminoderivatized chitosans against methicillin-resistant Staphylococcus aureus (MRSA).
This work describes the anti-MRSA activity of aminoderivatized chitosans. Two kinds of aminoethyl-chitosans (AEC), AEC90 and AEC50, having degrees of deacetylation of 90% and 50%, respectively, exhibited the strongest anti-MRSA activities by presenting MICs of 16-64 microg/mL against two standard strains and twelve clinical isolates. The bactericidal activity, thermal and pH stability, and cell membrane integrity effects of AEC90 and AEC50 are also discussed.
Lee
Dae-Sung
DS
Department of Microbiology, Pukyong National University, Busan 608-737, Republic of Korea.
Jeong
Seong-Yun
SY
Kim
Young-Mog
YM
Lee
Myung-Suk
MS
Ahn
Chang-Bum
CB
Je
Jae-Young
JY
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002462:Cell Membrane / Q000187:drug effects; D048271:Chitosan / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects*; D008826:Microbial Sensitivity Tests
D000900:Anti-Bacterial Agents; D048271:Chitosan