Xanthepinone, an antimicrobial polyketide from a soil fungus closely related to Phoma medicaginis.
The isolation, biological characterization, and structure elucidation of xanthepinone, a novel antifungal metabolite isolated from the broth of submerged cultures of a soil fungus, are described. Xanthepinone inhibits the conidial germination of Magnaporthe grisea (2 microg/mL), Phytophthora infestans (5 microg/mL), and Botrytis cinerea (10 microg/mL) while showing only weak antibacterial activity; cytotoxicity was not observed up to 50 microg/mL. Molecular taxonomy revealed that the producing strain is close to species in the genus Phoma as well as to uncultured soil fungi and endophytes.
Institut für Organische Chemie, Universität Hamburg, Martin-Luther-King-Platz 6, D-20146 Hamburg, Germany.
Johannes C
JC
Liermann
Heinz
H
Kolshorn
Till
T
Opatz
Eckhard
E
Thines
Heidrun
H
Anke
D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001203:Ascomycota / Q000737:chemistry*; D020171:Botrytis / Q000187:drug effects; D018360:Crystallography, X-Ray; D006367:HeLa Cells; D006575:Heterocyclic Compounds, 3-Ring / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D020082:Magnaporthe / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D055750:Phytophthora infestans / Q000187:drug effects
D000935:Antifungal Agents; D006575:Heterocyclic Compounds, 3-Ring; C545125:xanthepinone