Target pattern recognition by complement proteins of the classical and alternative pathways.
The complement system is a major component of the innate defence of animals against invading microorganisms, and is also essential for the recognition and clearance of damaged or structurally-altered host cells or macromolecules. The system is activated by three different pathways, each of which responds, using different recognition molecules, to a very wide range of activators. The recognition protein of the complement classical pathway, C1q is described in detail here, with comparisons to the alternative pathway.
MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, Oxford, UK.
Yu-Hoi
YH
Kang
Lee Aun
LA
Tan
Maria V
MV
Carroll
Madeleine E
ME
Gentle
Robert B
RB
Sim
D000595:Amino Acid Sequence; D000818:Animals; D017209:Apoptosis / Q000276:immunology; D015922:Complement C1q / Q000276:immunology* / Q000378:metabolism; D003170:Complement Pathway, Alternative / Q000276:immunology*; D003171:Complement Pathway, Classical / Q000276:immunology*; D006801:Humans; D007136:Immunoglobulins / Q000276:immunology / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000737:chemistry / Q000276:immunology* / Q000378:metabolism; D008969:Molecular Sequence Data; D011414:Properdin / Q000276:immunology* / Q000378:metabolism; D011951:Receptors, Complement / Q000737:chemistry / Q000276:immunology* / Q000378:metabolism
D007136:Immunoglobulins; D008562:Membrane Glycoproteins; D011951:Receptors, Complement; C032402:complement 1q receptor; D011414:Properdin; D015922:Complement C1q