Plasma fibrinogen levels and prognosis in patients with ovarian cancer: a multicenter study.
BACKGROUND
To evaluate pretherapeutic plasma fibrinogen levels as a prognostic parameter in patients with epithelial ovarian cancer (EOC). Materials and Methods. In the present multicenter study, pretherapeutic plasma fibrinogen levels were evaluated in 422 patients with EOC. Plasma fibrinogen levels were correlated with clinicopathological parameters and patient survival.


RESULTS
The mean (standard deviation) pretherapeutic plasma fibrinogen level was 450.0 (150.1) mg/dl. Elevated plasma fibrinogen levels were associated with advanced tumor stage (p = .01) and the presence of a postoperative residual tumor mass (p < .001), but not with histological grade (p = .1) and histological type (p = .8). In a multivariate Cox regression model, tumor stage (p < .001 and p < .001), postoperative residual tumor mass (p = .001 and p = .008), and plasma fibrinogen level (p < .001 and p = .002), but not histological type (p = .8 and p = .2), patient age (p = .9 and p = .9), and serum cancer antigen 125 (p = 0.2 and p = 0.3) and C-reactive protein (p = .2 and p = .3) levels, were associated with disease-free and overall survival, respectively. Histological grade was associated with overall but not with disease-free survival (p = .01 and p = .8), respectively.


CONCLUSIONS
Pretherapeutic plasma fibrinogen levels can be used as an independent prognostic parameter in patients with EOC.
Polterauer
Stephan
S
Department of Obstetrics & Gynecology, Medical University of Vienna, Waehringer Guer 18-20, A-1090 Vienna, Austria. stephan.polterauer@meduniwien.ac.at
Grimm
Christoph
C
Seebacher
Veronika
V
Concin
Nicole
N
Marth
Christian
C
Tomovski
Caroline
C
Husslein
Heinrich
H
Leipold
Heinz
H
Hefler-Frischmuth
Katrin
K
Tempfer
Clemens
C
Reinthaller
Alexander
A
Hefler
Lukas
L
D000367:Age Factors; D000704:Analysis of Variance; D000951:Antigens, Neoplasm / Q000097:blood; D014408:Biomarkers, Tumor / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D018572:Disease-Free Survival; D005260:Female; D005340:Fibrinogen / Q000032:analysis / Q000378:metabolism*; D006801:Humans; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D009367:Neoplasm Staging; D018365:Neoplasm, Residual; D010051:Ovarian Neoplasms / Q000097:blood* / Q000401:mortality* / Q000473:pathology; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies
D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D005340:Fibrinogen; D002097:C-Reactive Protein