[Correlation between oligohydramnios and abnormal expressions of TXA2, PGI2 and TXA2R in the umbilical arterial blood and placenta].
OBJECTIVE
To investigate the roles of thromboxane A(2) (TXA(2)) and prostaglandin I(2) (PGI(2)) in development of oligohydramnios.


METHODS
The concentration of TXB(2) and 6-keto-PGF1 in umbilical cord blood collected from 30 normal parturients (control) and 30 parturients with oligohydramnios was detected by radioimmunoassay to calculate the TXA(2)/PGI(2) ratio. Immunohistochemistry was performed to detect the contents of TXA(2)R in vascular endothelial cell in the placental villi.


RESULTS
Compared with the control group, the concentration of umbilical cord blood TXB(2) in oligohydramnios group was significantly increased (P<0.01), but the elevation of 6-keto-PGF(2) concentration was not statistically significant (P>0.05). The oligohydramnios group showed significantly higher positivity rates of TXB2 and 6-keto-PGF1 in than the control group (P<0.01), and the positivity rate of TXA(2)R in the vascular endothelial cells in the placental villi was also significantly higher in the oligohydramnios group (22/30, 77.3% vs 11/30, 36.7%, P<0.05). Most of the TXA(2)R-positive cases in the oligohydramnios group showed strong positivities of TXA(2)R.


CONCLUSIONS
Abnormal elevation of TXA(2) concentration in the umbilical cord blood and the TXA(2)/PGI(2) imbalance are responsible for the development of oligohydramnios.
Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, China. wangzhijian2046@sina.com
Zhi-jian
ZJ
Wang
Yan-hong
YH
Yu
Jie
J
Chen
Ying-ting
YT
Zhao
D000328:Adult; D000527:Alprostadil / Q000031:analogs & derivatives / Q000097:blood; D011464:Epoprostenol / Q000097:blood*; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D006801:Humans; D016104:Oligohydramnios / Q000378:metabolism*; D010920:Placenta / Q000737:chemistry*; D011247:Pregnancy; D011863:Radioimmunoassay; D044244:Receptors, Thromboxane A2, Prostaglandin H2 / Q000737:chemistry*; D013928:Thromboxane A2 / Q000097:blood*
D044244:Receptors, Thromboxane A2, Prostaglandin H2; D013928:Thromboxane A2; C022950:6-ketoprostaglandin E1; D011464:Epoprostenol; D000527:Alprostadil