[The roles of microRNAs in cardiac remodeling].
MicroRNAs, a class of small RNA molecules of approximately 22 nucleotides, are implicated in many biological processes as negative regulators of gene expression. MicroRNAs, primarily through base pairing to the 3' untranslated region (UTR) of target mRNAs, lead to inhibiting the translation or promoting the degradation of target mRNA. Recent studies have revealed important roles of microRNAs as regulators of the growth, development, function, and stress responsiveness of the heart. Here we overview the current research finding on microRNA in heart in order to disclose the progress of microRNA in cardiac remodeling.
Jiang
Xiao-Ying
XY
Department of Genetics and Molecular Biology, Medical College of Xi'an, Jiaotong University, Xi'an 710061, China.
Lu
She-Min
SM
D000818:Animals; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism; D012084:Renin-Angiotensin System; D020257:Ventricular Remodeling
D035683:MicroRNAs