An expanding job description for bcl6.
B cell lymphoma/leukemia gene 6 (Bcl6) is well known as a master regulator of germinal center (GC) B cell differentiation. Now, three new publications demonstrate that Bcl6 also plays a second role in GC response, in that it is both required and sufficient to drive the differentiation of T follicular helper cells.
Bi
Enguang
E
Department of Cell Biology, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY 10461, USA.
Ye
B Hilda
BH
D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology; D002454:Cell Differentiation; D004268:DNA-Binding Proteins / Q000235:genetics / Q000276:immunology*; D018858:Germinal Center / Q000166:cytology / Q000276:immunology; D006801:Humans; D051379:Mice; D051560:Proto-Oncogene Proteins c-bcl-6; D006377:T-Lymphocytes, Helper-Inducer / Q000166:cytology* / Q000276:immunology
C084103:BCL6 protein, human; C490010:Bcl6 protein, mouse; D004268:DNA-Binding Proteins; D051560:Proto-Oncogene Proteins c-bcl-6