Core decompression and implantation of calcium phosphate cement/Danshen drug delivery system for treating ischemic necrosis of femoral head at Stages I, II and III of antigen reactive cell opsonization.
OBJECTIVE
To introduce a new method using calcium phosphate cement/Danshen drug delivery system for treating ischemic necrosis of the femoral head and evaluate its curative effect.


METHODS
From May 2000 to June 2005, 48 adult patients (54 hips) with ischemic necrosis of the femoral head at Stages I, II and III of antigen reactive cell opsonization (ARCO) were treated with implantation of calcium phosphate cement/Danshen drug delivery system in the involved femoral head. The operation consisted of removal of the necrotic bone under weight-loading cartilage and the implantation of phosphate cement/Danshen drug delivery system, and all manipulations were made percutaneously through a bone tunnel in the trochanter. The functions of the hip joint were evaluated and X-ray films were taken preoperatively and postoperatively.


RESULTS
Postoperative follow-up was 45.5 months on average, ranging from 27 to 78 months. According to the evaluation criterion of "Dandong 1995" for therapeutic effect of adult ischemic necrosis of the femoral head, the therapeutic effects were excellent in 33 hips, good in 17, fair in 3 and poor in 1, with the excellent and good rate of 92.6%.


CONCLUSIONS
This method is relatively simple with little invasion. It not only improves the microcirculation of the femoral head by local application of traditional Chinese medicine, but also provides mechanic buttress in the weight-loading area to prevent collapse during repairing, which is beneficial to repair and reconstruction of femoral head. It may be a choice of minimal invasion surgery for ischemic necrosis of the femoral head at Stages I, II and III of ARCO.
Institute of Composite Material, Tianjin University, Tianjin 300072, China. boneman@163.com
Hong-jiang
HJ
Jiang
Xiang-jie
XJ
Huang
Yuan-chao
YC
Tan
De-zhong
DZ
Liu
Liang
L
Wang
D000328:Adult; D000368:Aged; D001843:Bone Cements; D002130:Calcium Phosphates / Q000008:administration & dosage*; D019299:Decompression, Surgical; D016503:Drug Delivery Systems; D005260:Female; D005270:Femur Head / Q000098:blood supply; D005271:Femur Head Necrosis / Q000000981:diagnostic imaging / Q000628:therapy*; D006801:Humans; D007511:Ischemia / Q000628:therapy; D008297:Male; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D011859:Radiography; D027561:Salvia miltiorrhiza
D001843:Bone Cements; D002130:Calcium Phosphates; C020243:calcium phosphate