Association of glycated albumin, but not glycated hemoglobin, with calcaneus quantitative ultrasound in male hemodialysis patients with type 2 diabetes mellitus.
Sustained high glucose impairs bone metabolism in patients with type 2 diabetes mellitus (T2DM). In this study, the relationship between glycemic control and bone metabolism was examined in male hemodialysis (HD) patients with T2DM. To avoid the effect of menstruation and the menstrual cycle, obesity, and glycosuria-induced hypercalciuria on bone metabolism, male anuric nonobese HD patients with T2DM (n = 42) were enrolled. Calcaneus stiffness index (SI) was determined using ultrasound after HD session. Casual plasma glucose (PG), glycated hemoglobin (HbA(1c)), and glycated albumin (GA) were measured before the HD session. In simple regression analysis, log PG (r = -0.333, P < .05) and log GA (r = -0.350, P < .05), but not log HbA(1c) (r = -0.134, P = .3985), exhibited significant and negative correlations with calcaneus SI. In multiple regression analysis including log BMI, log cCa x Pi product, and log PG, log PG was associated significantly in a negative manner with calcaneus SI, in addition to log cCa x Pi product. When log PG was replaced with log GA or log HbA(1c), log GA, but not log HbA(1c), emerged as a significant factor associated. The mechanism as to why HbA(1c) failed to associate could be explained by its false reduction by erythropoietin injection. The present study supported the notion of GA as an appropriate indicator for glycemic control in HD patients with T2DM. Furthermore, it is suggested that poor glycemic control might be a significant factor toward decreasing calcaneus SI in T2DM HD patients.
Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Abeno-ku, Osaka 545-8585, Japan.
Shinsuke
S
Yamada
Masaaki
M
Inaba
Shigeki
S
Okada
Yasuo
Y
Imanishi
Katsuhito
K
Mori
Masanori
M
Emoto
Eiji
E
Ishimura
Yoshiki
Y
Nishizawa
D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D001842:Bone and Bones / Q000378:metabolism; D002111:Calcaneus / Q000000981:diagnostic imaging* / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy / Q000378:metabolism*; D003928:Diabetic Nephropathies / Q000378:metabolism*; D004921:Erythropoietin / Q000627:therapeutic use; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006023:Glycoproteins / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins; D012044:Regression Analysis; D006435:Renal Dialysis; D012709:Serum Albumin / Q000378:metabolism*; D014463:Ultrasonography
D001786:Blood Glucose; D004921:Erythropoietin; D006442:Glycated Hemoglobin; D006023:Glycoproteins; D011994:Recombinant Proteins; D012709:Serum Albumin