Boosted protease inhibitors as a therapeutic option in the treatment of HIV-infected children.
OBJECTIVE
Paediatric HIV treatment must address various special considerations. Administration of pharmacokinetically enhanced protease inhibitors (PIs) can improve paediatric therapeutic outcomes. The objective of this study was to review the use of boosted PI regimens in children.


METHODS
Systematic literature searches of published manuscripts and conference databases using generic drug names and specific keywords were performed to ensure thorough and balanced reporting of available data.


RESULTS
Boosted PI regimens offer multiple options across a range of ages and are efficacious in naïve and experienced children; safety and tolerability are similar to those observed in adults. Novel boosted PI simplification approaches may foster adherence and diminish resistance.


CONCLUSIONS
Boosted PIs are key components of first- and second-line treatments in children. Identifying factors associated with the response to highly active antiretroviral therapy in children may ultimately permit individualized therapies.
Ramos
Jt
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Department of Paediatrics, University Hospital of Getafe, Madrid, Spain. jtramos.hugf@salud.madrid.org
D000293:Adolescent; D000328:Adult; D017954:Africa South of the Sahara; D000367:Age Factors; D023241:Antiretroviral Therapy, Highly Active / Q000379:methods* / Q000639:trends; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D003906:Developing Countries; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D017320:HIV Protease Inhibitors / Q000627:therapeutic use*; D015497:HIV-1; D006297:Health Services Accessibility; D006801:Humans; D007223:Infant; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control; D055118:Medication Adherence; D018894:Reverse Transcriptase Inhibitors / Q000627:therapeutic use; D016896:Treatment Outcome; D019562:Viral Load / Q000187:drug effects*; D055815:Young Adult
D017320:HIV Protease Inhibitors; D018894:Reverse Transcriptase Inhibitors