Cancer cell apoptotic pathways mediated by PEDF: prospects for therapy.
Pigment epithelium-derived factor (PEDF) has roles in antiangiogenesis and antitumourigenesis that are intimately entwined and is showing promise as a potential anticancer agent. However, the function of PEDF in the deregulated apoptotic pathways of malignant cells must first be fully characterized. Here, we review the currently known apoptotic pathways that are relevant to PEDF and cancer. Recently, a pathway that includes the PEDF receptor, PPARgamma and p53 has emerged. It is hoped that further characterization of this and other pathways involved in cancer will bring to light potential new therapeutic targets and approaches, which due to their specificity might be free of the morbidity associated with conventional chemotherapy.
Department of Orthopaedics and University of Melbourne Department of Surgery, St. Vincent's Hospital, VIC, Australia.
Matthew L
ML
Broadhead
Crispin R
CR
Dass
Peter F M
PF
Choong
D000818:Animals; D017209:Apoptosis; D005136:Eye Proteins / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000378:metabolism* / Q000503:physiopathology / Q000628:therapy*; D009414:Nerve Growth Factors / Q000235:genetics / Q000378:metabolism*; D047495:PPAR gamma / Q000235:genetics / Q000378:metabolism; D015843:Serpins / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism; D000099174:Pigment Epithelium-Derived Factor
D005136:Eye Proteins; D009414:Nerve Growth Factors; D047495:PPAR gamma; D015843:Serpins; D016159:Tumor Suppressor Protein p53; D000099174:Pigment Epithelium-Derived Factor