Association of polymorphisms of the tryptophan hydroxylase 2 gene with risk for bipolar disorder or suicidal behavior.
Bipolar disorder (BD) is a severe psychiatric illness characterized by the occurrence of elevated mood alternating with depressive episodes, having a estimated lifetime prevalence of 0.4-1.6% using DSM-IV criteria. Disturbances of the central serotonergic system has been associated with the pathophysiology of affective disorders and suicidal behavior. Tryptophan hydroxylase 2 (TPH2) which is a rate limiting enzyme in the serotonin synthesis is considered an important candidate gene associated with psychiatric disorders. Our sample consisted of 527 subjects (303 diagnosed with bipolar disorder and 224 healthy controls) which were genotyped for eight tagSNPs (rs4448731, rs4565946, rs11179000, rs7955501, rs10506645, rs4760820, rs1487275 and rs10879357) covering the whole gene of the human TPH2. Statistical analyses were performed using UNPHASED version 3.0.12 and Haploview((R)). Single markers, genotype and haplotype association analysis did not show significant genetic association with bipolar disorder or suicidal behavior. Our findings do not support the association between diagnosis of BD or suicidal behavior and TPH2 polymorphisms.
Instituto Nacional de Ciência e Tecnologia de Medicina Molecular, Laboratório de Neurociências e Genética Molecular, Faculdade de Medicina, Universidade Federal de Minas Gerais, Av. Prof. Alfredo Balena 190, 30130-100 Belo Horizonte, MG, Brazil. simonebecho@gmail.com <simonebecho@gmail.com>
Simone Becho
SB
Campos
Débora Marques
DM
Miranda
Bruno Rezende
BR
Souza
Patricia Araújo
PA
Pereira
Fernando Silva
FS
Neves
Maria Aparecida Camargos
MA
Bicalho
Paulo Henrique Casadei
PH
Melillo
Juliana
J
Tramontina
Flávio
F
Kapczinski
Marco Aurélio
MA
Romano-Silva
Humberto
H
Correa
D000328:Adult; D001714:Bipolar Disorder / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study / Q000379:methods; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D016728:Self-Injurious Behavior / Q000235:genetics*; D014365:Tryptophan Hydroxylase / Q000235:genetics*
C494784:TPH2 protein, human; D014365:Tryptophan Hydroxylase