Synthesis of Oxadiazole-2-oxide Analogues as Potential Antischistosomal Agents.
The synthesis of several 1,2,5-oxadiazole-2-oxide (Furoxan) analogues is described herein. These compounds were prepared in an effort to probe the SAR around the phenyl substituent and oxadiazole core for our studies toward thioredoxin-glutathione reductase (TGR) inhibition and anti-schistosomal activity.
Rai
Ganesha
G
NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, USA.
Thomas
Craig J
CJ
Leister
William
W
Maloney
David J
DJ