2-Oxoglutarate analogue inhibitors of prolyl hydroxylase domain 2.
Analogues of the 2-oxoglutarate cosubstrate of the human oxygen sensing enzyme prolyl hydroxylase domain 2 (PHD2) with variations in the potential iron-chelating group were screened as inhibitors and for binding (using non-denaturing electrospray ionization mass spectrometry) to PHD2.
Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK.
Jasmin
J
Mecinović
Christoph
C
Loenarz
Rasheduzzaman
R
Chowdhury
Christopher J
CJ
Schofield
D031541:Fluorescence Resonance Energy Transfer; D006801:Humans; D007502:Iron Chelating Agents; D007656:Ketoglutaric Acids / Q000737:chemistry* / Q000494:pharmacology; D011393:Procollagen-Proline Dioxygenase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D021241:Spectrometry, Mass, Electrospray Ionization
D007502:Iron Chelating Agents; D007656:Ketoglutaric Acids; D011393:Procollagen-Proline Dioxygenase