The role of basophils in helminth infection.
Protective immunity against gastrointestinal and tissue dwelling helminths is coordinated by interaction of different effector cells of the innate and adaptive immune system. Helminths induce a strong type 2 immune response which is characterized by high levels of IgE and increased numbers of Th2 cells, eosinophils, mast cells and basophils. Basophils are rapidly mobilized after helminth infection and can be efficiently recruited into lymphoid and peripheral tissues where they execute their effector functions. Recent work demonstrated that basophils contribute to initiation and execution of type 2 immunity. This review discusses the potential role of basophils for protective immunity against helminths.
Voehringer
David
D
Institute for Immunology, University of Munich, Goethestrasse 31, 80336 Munich, Germany. david.voehringer@med.uni-muenchen.de
D000818:Animals; D001491:Basophils / Q000166:cytology / Q000276:immunology*; D002454:Cell Differentiation; D019070:Cell Lineage; D005434:Flow Cytometry; D006373:Helminthiasis / Q000276:immunology*; D006376:Helminths / Q000276:immunology*; D006801:Humans; D007150:Immunohistochemistry; D051379:Mice