Thyroid stimulation with recombinant human thyrotropin in healthy cats, cats with non-thyroidal illness and in cats with low serum thyroxin and azotaemia after treatment of hyperthyroidism.
This study investigated the recombinant human thyrotropin (rhTSH) stimulation test in healthy cats (group 1), cats with non-thyroidal illness (group 2) and cats with low serum total T(4) (TT(4)) and azotaemia after (131)I treatment (group 3). Serum TT(4) responses and thyroidal pertechnetate uptake after administration of 25 microg rhTSH IV were assessed. Baseline serum TT(4) was significantly lower in group 3 compared with group 1, but not between other group pairs. Serum TT(4) increased significantly in groups 1 and 2 but not in group 3 after rhTSH administration. Post-rhTSH serum TT(4) concentrations differed significantly between groups 1 and 3 and groups 2 and 3, but not between groups 1 and 2. Thyroid/salivary gland uptake ratio (T/S uptake ratio) differed only significantly between groups 1 and 3. Stimulation with rhTSH is valuable to differentiate euthyroidism from iatrogenic hypothyroidism in cats.
van Hoek
Ingrid M
IM
Department of Medicine and Clinical Biology of Small Animals, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium. ivanhoek@royal-canin.fr
Vandermeulen
Eva
E
Peremans
Kathelijne
K
Daminet
Sylvie
S
D000818:Animals; D053099:Azotemia / Q000097:blood / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000662:veterinary*; D016022:Case-Control Studies; D002371:Cat Diseases / Q000097:blood / Q000175:diagnosis / Q000000981:diagnostic imaging; D002415:Cats; D003937:Diagnosis, Differential; D005260:Female; D006980:Hyperthyroidism / Q000097:blood / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000662:veterinary*; D007037:Hypothyroidism / Q000097:blood / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000662:veterinary; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D011877:Radionuclide Imaging / Q000662:veterinary; D011994:Recombinant Proteins / Q000494:pharmacology; D013670:Sodium Pertechnetate Tc 99m; D013961:Thyroid Gland / Q000000981:diagnostic imaging / Q000187:drug effects / Q000502:physiology*; D013972:Thyrotropin / Q000494:pharmacology*; D013974:Thyroxine / Q000097:blood*
D007457:Iodine Radioisotopes; D011994:Recombinant Proteins; D013972:Thyrotropin; D013670:Sodium Pertechnetate Tc 99m; D013974:Thyroxine