Prediction of the PCDD/F and dl-PCB 2005-WHO-TEQ content based on the contribution of six congeners: toward a new screening approach for fish samples?
Current European Union regulation regarding polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans (PCDD/Fs) and dioxin-like polychlorinated biphenyls (dl-PCBs) in food and feed is based on Toxic Equivalent Quotient (TEQ) concept. For confirmatory purpose, the isotope-dilution method associated to a measurement by gas chromatography coupled with high resolution mass spectrometry is usually the method of choice for precisely measuring the 29 target congeners in three separated fractions. Time and cost related to these analyses are very significant. Various kinds of screening concepts can be considered. In the present study, we elaborated and validated a prediction model for the 2005 World Health Organization TEQ in fish, based on the measurement of 4 PCDD/F and 2 non-ortho dl-PCB congeners, potentially analyzable in a single extracted fraction by gas chromatography coupled with mass spectrometry. Large independent datasets have been used for model elaboration (n=108) and validation (n=363, n=357 and n=6).
Laboratoire d'Etude des Résidus et Contaminants dans les Aliments (LABERCA), Ecole Nationale Vétérinaire de Nantes (ENVN), USC INRA 2013, BP 50707, 44307 Nantes Cedex 3, France. cariou@vet-nantes.fr
Ronan
R
Cariou
Philippe
P
Marchand
Anaïs
A
Vénisseau
Aline
A
Brosseaud
Dominique
D
Bertrand
El Mostafa
el M
Qannari
Jean-Philippe
JP
Antignac
Bruno
B
Le Bizec
D000818:Animals; D001572:Benzofurans / Q000737:chemistry*; D000072338:Dibenzofurans, Polychlorinated; D004785:Environmental Pollutants / Q000737:chemistry; D005399:Fishes; D005506:Food Contamination / Q000032:analysis; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D007536:Isomerism; D011078:Polychlorinated Biphenyls / Q000737:chemistry*; D000072317:Polychlorinated Dibenzodioxins / Q000031:analogs & derivatives* / Q000737:chemistry; D017747:Seafood / Q000032:analysis*
D001572:Benzofurans; D000072338:Dibenzofurans, Polychlorinated; D004785:Environmental Pollutants; D000072317:Polychlorinated Dibenzodioxins; D011078:Polychlorinated Biphenyls