Monocyte retention in the pathology of atherosclerosis.
Atherosclerosis is a type of chronic inflammatory disease characterized by the presence of monocyte-derived cells in all stages. Monocytes, macrophages, dendritic and foam cells play important roles in the uptake of oxidized lipids, lesion development, and ultimate plaque disruption. Much is known about the mechanisms of monocyte recruitment in the lumen; however, the fate of monocytes after they enter the artery wall is not well understood. In this review, some of the interesting recent results related to monocyte retention after their migration across the endothelium in the pathology of atherosclerosis will be highlighted. The authors have focused on monocyte inside-out equilibrium, apoptosis and proliferation regulation, and the role of vascular smooth muscle cells in monocyte retention in atherosclerosis. They have also proposed potential treatments for atherosclerosis that target inflammation and monocyte/macrophage retention.
Beckman Research Institute of City of Hope, Gonda Diabetes Center, 1500 East Duarte Road, Duarte, CA 91010, USA. rnatarajan@coh.org
Rama
R
Natarajan
Qiangjun
Q
Cai