Low serum osteoprotegerin levels in normoalbuminuric type 1 diabetes mellitus.
The aim of this study is to establish whether abnormal mineral metabolism is present in patients with type 1 DM with normal renal function and in the absence of microalbuminuria. Serum levels of 1,25-dihydroxyvitamin D, osteoprotegerin (OPG) and receptor activator for nuclear factor kappa β ligand (RANKL) and other determinants of bone metabolism were measured in 35 patients with type 1 DM and in 25 age-, sex- and ethnicity-matched healthy controls. Serum OPG (1.98 vs. 2.98 pmol/l: P = 0.001), 1,25-dihydroxyvitamin D (41.1 vs. 48.2 pmol/l: P = 0.035) and magnesium (0.84 vs. 0.89 mmol/l P = 0.029) levels were significantly lower in patients with type 1 DM compared to normal controls. RANKL levels were similar in both groups. The groups did not differ with respect to calcium, phosphate, PTH, 25-hydroxyvitamin D, tubular reabsorption of phosphate and cross-linked N-telopeptides of type 1-collagen levels. Abnormalities of mineral metabolism including low serum OPG and 1,25-dihydroxyvitamin D levels occur in patients with type 1 DM with normal renal function and in the absence of microalbuminuria. These abnormalities may promote altered bone metabolism and vascular pathology.
Singh
Dhruv K
DK
Renal Unit, Lister Hospital, East and North Herts NHS Trust, Stevenage SG1 4AB, UK. dsingh4@nhs.net
Winocour
Peter
P
Summerhayes
Bev
B
Viljoen
Adie
A
Sivakumar
G
G
Farrington
Ken
K
D000328:Adult; D015519:Bone Density; D001842:Bone and Bones / Q000378:metabolism; D016022:Case-Control Studies; D048909:Diabetes Complications / Q000097:blood / Q000209:etiology; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000150:complications; D015536:Down-Regulation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008903:Minerals / Q000097:blood; D053244:Osteoprotegerin / Q000097:blood*; D053245:RANK Ligand / Q000097:blood; D014807:Vitamin D / Q000031:analogs & derivatives / Q000097:blood
D008903:Minerals; D053244:Osteoprotegerin; D053245:RANK Ligand; D014807:Vitamin D; C097949:1,25-dihydroxyvitamin D