N-Alkoxyl Templates for Diastereoselective Pyrrolidine Synthesis.
Intramolecular cyclization of N-alkoxyl amines are studied for the stereoselective preparation of 2, 4-disubstituted pyrrolidine derivatives. Reduction of oximes under acidic conditions by NaBH(3)CN afforded the corresponding nucleophilic hydroxylamine derivatives, which subsequently cyclized via S(N)2' mechanism to give the desired N-alkoxyl pyrrolidines.
College of Pharmaceuticals and Biotechnology, Tianjin University, Tianjin 300072.
Song Qing
SQ
Wang
Omar A
OA
Ibrahimi
Pan
P
Li
Kang
K
Zhao