[Germinoma responsible for central diabetes insipidus].
We report the case of a 20-year-old woman who presented with sudden onset of polydipsia and polyuria. A diagnosis of diabetes insipidus was confirmed and the MRI showed a pituitary stalk enlargement. The patient was treated with Minirin. Two years later, she developed a panhypopituitarism. The MRI showed an intrasellar mass with an enlargement of the pituitary gland. A biopsy confirmed a germinoma. The patient was treated with radiotherapy with a partial response as only a part of the mass disappeared. This case highlights the importance of the clinical and radiological follow-up of central diabetes insipidus, especially when it is of unknown origin. The differential diagnosis will be reviewed.
CHR Citadelle, Liège, Belgique.
N
N
Bakoto
M
M
Strivay
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D050034:Antidiuretic Agents / Q000627:therapeutic use; D017024:Chemotherapy, Adjuvant; D003894:Deamino Arginine Vasopressin / Q000627:therapeutic use; D003919:Diabetes Insipidus / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000532:radiotherapy; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D005260:Female; D018237:Germinoma / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000532:radiotherapy; D006801:Humans; D006854:Hydrocortisone / Q000627:therapeutic use; D007018:Hypopituitarism / Q000209:etiology; D010911:Pituitary Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000532:radiotherapy; D011141:Polyuria / Q000209:etiology; D018714:Radiotherapy, Adjuvant; D013974:Thyroxine / Q000627:therapeutic use; D016896:Treatment Outcome
D000893:Anti-Inflammatory Agents; D050034:Antidiuretic Agents; D003894:Deamino Arginine Vasopressin; D013974:Thyroxine; D006854:Hydrocortisone