Inferior petrosal sinus sampling in the diagnosis of sellar neuropathology.
Because no single test is definitive for Cushing's disease (CD), establishing the diagnosis has remained a challenge that relies on building a critical mass of evidence. The differential diagnosis of corticotropin (ACTH)-dependent Cushing's syndrome (CS) traditionally has rested on noninvasive biochemical and radiologic testing. Bilateral inferior petrosal sinus sampling (BIPSS) is an invasive procedure that has become part of the diagnostic armamentarium surrounding CD. When used appropriately-that is, for patients who have biochemically confirmed ACTH-dependent CS but discordant biochemical or radiologic studies-BIPSS is the reference standard confirmatory test for CD.
Department of Neurological Surgery, University of Pittsburgh Medical Center, 200 Lothrop Street, Suite B-400, Pittsburgh, PA 15213-2582, USA.
Nestor D
ND
Tomycz
Michael B
MB
Horowitz
D000324:Adrenocorticotropic Hormone / Q000032:analysis* / Q000097:blood*; D003392:Cranial Sinuses / Q000033:anatomy & histology / Q000000981:diagnostic imaging / Q000601:surgery*; D003937:Diagnosis, Differential; D005938:Glucocorticoids / Q000097:blood / Q000378:metabolism; D006801:Humans; D007431:Intraoperative Complications / Q000517:prevention & control; D017591:Petrosal Sinus Sampling / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods*; D047748:Pituitary ACTH Hypersecretion / Q000097:blood* / Q000175:diagnosis* / Q000503:physiopathology; D010902:Pituitary Gland / Q000378:metabolism / Q000503:physiopathology; D011237:Predictive Value of Tests; D011859:Radiography; D012658:Sella Turcica / Q000473:pathology
D005938:Glucocorticoids; D000324:Adrenocorticotropic Hormone