Enteric nervous system development: Recent progress and future challenges.
The enteric nervous system is the largest subdivision of the peripheral nervous system that plays a critical role in digestive functions. Despite considerable progress over the last 15 years in understanding the molecular and cellular mechanisms that control the development of the enteric nervous system, several questions remain unanswered. The present review will focus on recent progress on understanding the development of the mammalian enteric nervous system and highlight interesting directions of future research.
Laranjeira
Cátia
C
MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London, United Kingdom. claranj@nimr.mrc.ac.uk
Pachnis
Vassilis
V
D000818:Animals; D017209:Apoptosis; D019070:Cell Lineage; D002465:Cell Movement; D017615:Enteric Nervous System / Q000166:cytology / Q000196:embryology* / Q000254:growth & development / Q000502:physiology; D005544:Forecasting; D006627:Hirschsprung Disease / Q000196:embryology / Q000473:pathology; D018398:Homeodomain Proteins / Q000502:physiology; D006801:Humans; D007313:Insecta / Q000196:embryology / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout; D039902:Multipotent Stem Cells / Q000166:cytology / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000502:physiology; D009432:Neural Crest / Q000166:cytology; D055495:Neurogenesis / Q000502:physiology; D009457:Neuroglia / Q000166:cytology / Q000378:metabolism; D009474:Neurons / Q000166:cytology / Q000378:metabolism; D010528:Peristalsis / Q000502:physiology; D051096:Proto-Oncogene Proteins c-ret / Q000172:deficiency / Q000235:genetics / Q000502:physiology; D014157:Transcription Factors / Q000502:physiology; D014714:Vertebrates / Q000196:embryology / Q000502:physiology
D018398:Homeodomain Proteins; C109220:NBPhox protein; D009419:Nerve Tissue Proteins; D014157:Transcription Factors; D051096:Proto-Oncogene Proteins c-ret; C494999:Ret protein, mouse