Characterization of the hemagglutinin gene of subtype H9 avian influenza viruses isolated in 2007-2009 in China.
Subtype H9 avian influenza viruses (AIVs) circulating in China have aroused concerns for their impact on poultry and risk to public health. In this report, three surveys of the viruses were reported, and the hemagglutinin gene of 55 strains of the viruses isolated in China in 2007-2009 was sequenced and analyzed. The results indicated that the prevalence of the viruses was rising in China, and most of the H9 AIVs circulating in the past decade in China belonged to sublineage h9.4.2. The viruses isolated in China in 2007-2009 were a little different from previous strains (genetic distances >7.1%). Meanwhile, a presumably predominant clade of the viruses circulating in China in 2007-2009 was identified. Mutation analysis suggested that the viruses have become of greater risk to public health in recent years.
China Animal Health & Epidemiology Center, Qingdao 266032, China.
Kang
K
Ji
Wen-Ming
WM
Jiang
Shuo
S
Liu
Ji-Ming
JM
Chen
Jie
J
Chen
Guang-Yu
GY
Hou
Jin-Ping
JP
Li
Bao-Xu
BX
Huang
D000818:Animals; D002645:Chickens / Q000821:virology; D002681:China; D016000:Cluster Analysis; D004252:DNA Mutational Analysis; D004372:Ducks / Q000821:virology; D006389:Hemagglutinins, Viral / Q000235:genetics*; D009980:Influenza A virus / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification / Q000472:pathogenicity; D005585:Influenza in Birds / Q000821:virology*; D017720:Molecular Epidemiology; D008969:Molecular Sequence Data; D010802:Phylogeny; D011201:Poultry Diseases / Q000821:virology*; D012367:RNA, Viral / Q000235:genetics; D017422:Sequence Analysis, DNA; D017385:Sequence Homology; D014774:Virulence
D006389:Hemagglutinins, Viral; D012367:RNA, Viral; C458881:hemagglutinin fusogenic peptide, influenza virus