One-pot synthesis of 2-pyridones via chemo- and regioselective tandem Blaise reaction of nitriles with propiolates.
The Blaise reaction intermediate, generated in situ from Reformatsky reagent and nitrile, reacted with propiolates in a chemo- and regioselective manner to afford 2-pyridone derivatives in good to excellent yields.
Department of Chemistry and Nano Science (BK21), Ewha Womans University, Seoul 120-750, Korea.
Yu Sung
YS
Chun
Ka Yeon
KY
Ryu
Young Ok
YO
Ko
Joo Yeon
JY
Hong
Jongki
J
Hong
Hyunik
H
Shin
Sang-gi
SG
Lee
D000480:Alkynes / Q000737:chemistry*; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry; D011422:Propionates / Q000737:chemistry*; D011728:Pyridones / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D015032:Zinc / Q000737:chemistry
D000480:Alkynes; D009570:Nitriles; D009942:Organometallic Compounds; D011422:Propionates; D011728:Pyridones; C017679:2-hydroxypyridine; D015032:Zinc; C011537:propiolic acid