Assessment of sentinel nodes for gynecologic malignancies by natural orifices transluminal endoscopic surgery (NOTES): preliminary report.
OBJECTIVE
To assess the feasibility of sentinel lymph node (SLN) biopsy in gynecologic malignancies using natural orifices transluminal endoscopic surgery (NOTES) in an animal model.


METHODS
Ten female pigs were operated. Patent blue dye was injected in the paracervical region. The endoscope was introduced through a right lateral colpotomy. Internal iliac vessels were visualized followed by the identification of external iliac vessels. Bilateral dissection was performed to achieve visualization of the aorta and the vena cava. SLN colored in blue were bluntly dissected and then excised.


RESULTS
Mean operative time was 56+/-16 minutes. The mean number of SLN retrieved was 1.75+/-1.28. All but one SLN were identified by NOTES procedure. No major complication was observed in this series. A total of 19 SLN were harvested, of which 11 from the left side and 8 from the right side. Fifteen lymph nodes were obtained from the iliac vessels or the promontory and 4 from the lateral aortic or preaortic region.


CONCLUSIONS
In this study, we confirmed the feasibility of the SLN technique by NOTES. It can be considered as a potential alternative to reduce morbidity during staging procedures for gynecologic malignancies. Prospective randomized series are necessary to establish the safety and the real benefits of this new technique.
Bourdel
Nicolas
N
CHU Clermont-Ferrand, Department of Obstetrics and Gynecology, Polyclinique, Bd Léon Malfreyt, 63000 Clermont-Ferrand, France. nbourdel@chu-clermontferrand.fr
Kondo
William
W
Botchorishvili
Revaz
R
Poincloux
L
L
Niro
Julien
J
Rabischong
Benoit
B
Jardon
Kris
K
Pouly
Jean Luc
JL
Mage
Gerard
G
Canis
Michel
M
D000818:Animals; D004195:Disease Models, Animal; D004724:Endoscopy / Q000379:methods; D005240:Feasibility Studies; D005260:Female; D005833:Genital Neoplasms, Female / Q000473:pathology* / Q000601:surgery*; D013509:Gynecologic Surgical Procedures; D008197:Lymph Node Excision / Q000379:methods; D008198:Lymph Nodes / Q000473:pathology* / Q000601:surgery*; D009367:Neoplasm Staging; D021701:Sentinel Lymph Node Biopsy / Q000379:methods; D013552:Swine