Beta-amidoaldehydes via oxazoline hydroformylation.
4-Substituted oxazolines, which are readily synthesized from naturally occurring alpha-amino acids, are converted efficiently and stereospecifically to beta-amidoaldehydes in the presence of synthesis gas and catalytic dicobalt octacarbonyl.
Department of Chemistry and Chemical Biology, Baker Laboratory, Cornell University, Ithaca, NY 14853-1301, USA.
David S
DS
Laitar
John W
JW
Kramer
Bryan T
BT
Whiting
Emil B
EB
Lobkovsky
Geoffrey W
GW
Coates
D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D003035:Cobalt / Q000737:chemistry; D005740:Gases / Q000737:chemistry; D008968:Molecular Conformation; D010080:Oxazoles / Q000737:chemistry*; D013237:Stereoisomerism
D000447:Aldehydes; D005740:Gases; D010080:Oxazoles; D003035:Cobalt; C529955:dicobalt octacarbonyl