Bypassing stereoselectivity in the early steps of alkaloid biosynthesis.
Total synthesis of glycosylated seco-iridoid stereoisomers allows the identification and bypassing of the stereoselectivity of early steps in monoterpene indole alkaloid biosynthesis.
MIT Department of Chemistry, 77 Massachusetts Avenue, 18-592, Cambridge, MA 02139, USA.
Peter
P
Bernhardt
Nancy
N
Yerkes
Sarah E
SE
O'Connor
D000470:Alkaloids / Q000096:biosynthesis* / Q000737:chemistry*; D030008:Catharanthus / Q000201:enzymology; D005959:Glucosidases / Q000378:metabolism; D006031:Glycosylation; D007700:Kinetics; D013237:Stereoisomerism; D013379:Substrate Specificity
D000470:Alkaloids; D005959:Glucosidases; C456847:strictosidine glucosidase