Progress in aromatase research and identification of key future directions.
The IX International Aromatase Conference focused upon key developments in research related to the aromatase enzyme that had occurred since the last meeting. A session took place at the conclusion of conference discussing key areas for future research and issues currently facing researchers in the field. While significant progress on understanding structural elements of the enzyme and regulatory mechanisms of both the gene and protein provides an excellent basis for development of improved aromatase inhibitors and exploration of the important problem of aromatase inhibitor resistance, significant challenges remain. Increasing the speed with which findings are translated into clinical practice and finding an appropriate balance between basic and translational research were identified as areas which require further attention before the next meeting in 2010.
Dunbier
Anita K
AK
Academic Department of Biochemistry, Royal Marsden Hospital, London SW3 6JJ, United Kingdom. anita.dunbier@icr.ac.uk
Hong
Yanyan
Y
Masri
Selma
S
Brown
Kristy A
KA
Sabnis
Gauri J
GJ
Palomares
Melanie R
MR
D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D001141:Aromatase / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D047072:Aromatase Inhibitors / Q000627:therapeutic use*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D057170:Translational Research, Biomedical
D018931:Antineoplastic Agents, Hormonal; D047072:Aromatase Inhibitors; D001141:Aromatase