Novel ceramides from aerial parts of Saussurea involucrata Kar. et. Kir.
Novel ceramides, together with nine known compounds were isolated from aerial parts of the Saussurea involucrata Kar. et. Kir. The novel structures were determined by spectroscopic methods and microscale chemical degradation. The ceramides showed appreciable cytotoxicity against three human tumor cell lines including human promyelocytic leukemia (HL-60), human melanoma (A375-S2) and human cervical carcinoma (HeLa) cell lines. The results suggested that this class of ceramides may have potential as an antitumor agent.
Department of Phytochemistry, Shenyang Pharmaceutical University, Shenyang 110016, China.
Wei
W
Wu
Yang
Y
Qu
Huiyuan
H
Gao
Jingyu
J
Yang
Jianguo
J
Xu
Lijun
L
Wu
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002518:Ceramides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D030441:Saussurea / Q000737:chemistry*
D000972:Antineoplastic Agents, Phytogenic; D002518:Ceramides