Microscopic polyangiitis triggered by recurrent methicillin-resistant Staphylococcus aureus bacteremia.
Most of the purported links between microbial agents and primary small-vessel anti-neutrophilic antibody-positive (ANCA) vasculitides remain speculative. There is strong circumstantial evidence for the role of Staphylococcus aureus in the development of Wegener's granulomatosis, but its role in other ANCA-positive vasculitis syndromes is less clear. We describe a patient who developed a non-granulomatous, necrotizing small-vessel vasculitis with a positive anti-neutrophil cytoplasmic antibody of a perinuclear type (p-ANCA), along with anti-myeloperoxidase antibodies after recurrent episodes of methicillin-resistant Staphylococcus aureus bacteremia.
Kasmani
Rahil
R
Department of Internal Medicine, St Vincent Mercy Medical Center, 2213, Cherry Street, Toledo, OH 43608, USA. rahilkasmani@hotmail.com
Okoli
Kelechi
K
Naraharisetty
Kalpana
K
Gunning
William
W
Shapiro
Joseph I
JI
Ratnam
Shobha
S
D000368:Aged; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000032:analysis; D001323:Autoantibodies / Q000032:analysis; D016470:Bacteremia / Q000150:complications* / Q000628:therapy; D005260:Female; D005921:Glomerulonephritis / Q000382:microbiology / Q000473:pathology / Q000628:therapy; D006801:Humans; D055624:Methicillin-Resistant Staphylococcus aureus; D055953:Microscopic Polyangiitis / Q000276:immunology / Q000382:microbiology* / Q000628:therapy; D009195:Peroxidase / Q000276:immunology; D012008:Recurrence; D013203:Staphylococcal Infections / Q000150:complications* / Q000628:therapy
D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies; D009195:Peroxidase