Plasma levels and urinary excretion of amino acids by subjects with renal calculi.
Plasma levels and urinary amino acid excretions were estimated by high-performance liquid chromatography in 15 control subjects and 36 stone formers (SFs) classified according to the stone type: (1) 22 cases with calcium oxalate stones; (2) four cases with pure uric acid stones; (3) 10 cases with magnesium-ammonium phosphate stones, either pure or mixed with apatite. Some types of stones (namely oxalate and uric acid calculi) are mainly formed as a result of a metabolic deficiency that may affect the amino acid metabolism, and thus may be reflected in the urinary amino acid pattern. Data demonstrated clearly that there is a general tendency towards decreased amino acid excretions in all SFs with all types of stones. As a whole, one can observe a higher percentage of patients with calcium oxalate and phosphate calculosis, who have low urine excretions of amino acids; about 50% are the SFs with lower urine excretion of serine, glycine, taurine and i-leucine; the high percentage of patients with CaOX calculi shows lower urine excretions of tyrosine and ornithine.
Department of Urology, Alexandrov's University Hospital, Medical University, G. Sofiisky Blvd 1, 1431, Sofia, Bulgaria. stoyana_atanassova@abv.bg
Stoyanka Slavcheva
SS
Atanassova
P
P
Panchev
M
M
Ivanova
D000328:Adult; D000596:Amino Acids / Q000097:blood / Q000378:metabolism* / Q000652:urine; D001031:Apatites / Q000378:metabolism; D002129:Calcium Oxalate / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D007669:Kidney Calculi / Q000097:blood / Q000378:metabolism* / Q000652:urine; D017616:Magnesium Compounds / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010710:Phosphates / Q000378:metabolism; D000069877:Struvite; D014527:Uric Acid / Q000378:metabolism
D000596:Amino Acids; D001031:Apatites; D017616:Magnesium Compounds; D010710:Phosphates; D002129:Calcium Oxalate; D014527:Uric Acid; D000069877:Struvite