Salmonella--the ultimate insider. Salmonella virulence factors that modulate intracellular survival.
Salmonella enterica serovar Typhimurium is a common facultative intracellular pathogen that causes food-borne gastroenteritis in millions of people worldwide. Intracellular survival and replication are important virulence determinants and the bacteria can be found in a variety of phagocytic and non-phagocytic cells in vivo. Invasion of host cells and intracellular survival are dependent on two type III secretion systems, T3SS1 and T3SS2, each of which translocates a distinct set of effector proteins. However, other virulence factors including ion transporters, superoxide dismutase, flagella and fimbriae are also involved in accessing and utilizing the intracellular niche.
Ibarra
J Antonio
JA
Laboratory of Intracellular Parasites, NIAID, NIH, Rocky Mountain Laboratories, Hamilton, MT, USA.
Steele-Mortimer
Olivia
O
D001426:Bacterial Proteins / Q000502:physiology*; D003593:Cytoplasm / Q000382:microbiology*; D054884:Host-Pathogen Interactions; D006801:Humans; D050296:Microbial Viability; D012486:Salmonella typhimurium / Q000472:pathogenicity* / Q000502:physiology*; D037521:Virulence Factors / Q000502:physiology*
D001426:Bacterial Proteins; D037521:Virulence Factors