Dipyridodiazepinone derivatives; synthesis and anti HIV-1 activity.
Ten dipyridodiazepinone derivatives were synthesized and evaluated for their anti HIV-1 reverse transcriptase activity against wild-type and mutant type enzymes, K103N and Y181C. Two of them were found to be promising inhibitors for HIV-1 RT.
Chulabhorn Research Institute, Vibhavadee-Rangsit Highway, Bangkok 10210, Thailand.
Nisachon
N
Khunnawutmanotham
Nitirat
N
Chimnoi
Arunee
A
Thitithanyanont
Patchreenart
P
Saparpakorn
Kiattawee
K
Choowongkomon
Pornpan
P
Pungpo
Supa
S
Hannongbua
Supanna
S
Techasakul