Immunological reactivity against neuronal and non-neuronal antigens in sporadic adult-onset cerebellar ataxia.
In recent years, the involvement of the immune system in acquired forms of cerebellar ataxia has been frequently demonstrated. In this study, we describe 6 out of 49 patients with subacute or chronic progressive cerebellar ataxia in whom antibodies against neuronal and non-neuronal antigens were identified. Two women had anti-Yo antibodies; two patients had anti-gliadin antibodies in the presence of celiac disease; one patient had a complex autoimmune disorder associated with anti-Ro-52/SS-A and anti-muscle-specific kinase antibodies, and a patient developed subacute cerebellar syndrome associated with the presence of a prostatic adenocarcinoma and atypical antibodies reacting both with cerebellar tissue and with the prostatic tumor. Our study confirms previous findings in paraneoplastic syndromes, and indicates that at least 10% of sporadic cerebellar ataxia may be related to immune-mediated mechanisms.
SOD Genetica delle Malattie Neurodegenerative e Metaboliche, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italia.
Roberto
R
Fancellu
Davide
D
Pareyson
Elena
E
Corsini
Ettore
E
Salsano
Matilde
M
Laurà
Gaetano
G
Bernardi
Carlo
C
Antozzi
Francesca
F
Andreetta
Maurizio
M
Colecchia
Stefano
S
Di Donato
Caterina
C
Mariotti
D000230:Adenocarcinoma / Q000150:complications / Q000276:immunology; D001323:Autoantibodies / Q000276:immunology*; D015551:Autoimmunity / Q000276:immunology*; D015153:Blotting, Western; D002446:Celiac Disease / Q000150:complications / Q000276:immunology; D004576:Electromyography; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005903:Gliadin / Q000276:immunology; D005968:Glutamate Decarboxylase / Q000276:immunology; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000276:immunology; D009474:Neurons / Q000276:immunology; D011471:Prostatic Neoplasms / Q000150:complications / Q000276:immunology; D012261:Ribonucleoproteins / Q000276:immunology; D013132:Spinocerebellar Degenerations / Q000150:complications / Q000276:immunology*; D000099207:SS-A Antigen
D001323:Autoantibodies; D005903:Gliadin; D005968:Glutamate Decarboxylase; D009419:Nerve Tissue Proteins; D012261:Ribonucleoproteins; D000099207:SS-A Antigen; C095184:CDR2 protein, human