Continuous venovenous haemodiafiltration for metformin-induced lactic acidosis.
A 74-year-old man with cardiac failure and renal impairment was admitted to the cardiothoracic intensive care unit with metformin-induced lactic acidosis and shock. He was successfully treated with high-dose (80 ml/kg/hour) continuous venovenous haemodiafiltration. Lactic acidosis is a known complication of metformin and is associated with a high mortality. The use of high-dose continuous venovenous haemodiafiltration for this condition has not previously been reported.
Pan
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Department of Anaesthesia, National University Hospital, Singapore.
MacLaren
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D000140:Acidosis, Lactic / Q000139:chemically induced / Q000628:therapy; D000368:Aged; D016638:Critical Illness / Q000628:therapy; D006440:Hemofiltration / Q000379:methods*; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects*; D007362:Intensive Care Units; D008297:Male; D008687:Metformin / Q000009:adverse effects*; D016896:Treatment Outcome
D007004:Hypoglycemic Agents; D008687:Metformin