New agents in chronic myelogenous leukemia.
Multiple new agents are currently being developed in chronic myelogenous leukemia (CML). Most of these agents are now being investigated in patients who have developed resistance to imatinib. Their mechanisms of action are diverse and many may be synergistic with imatinib. These agents will be used soon in different combinations, most likely including imatinib, with the hope of obtaining a complete blockade of the intracellular pathways that are triggered by Bcr-Abl. If this is successful, complete eradication of disease may become a reality for the majority of patients with CML.
Department of Leukemia, The University of Texas, M. D. Anderson Cancer Center, Houston, Texas, USA. jcortes@mdanderson.org
Jorge
J
Cortes
Francis
F
Giles
D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D000077237:Arsenic Trioxide; D001152:Arsenicals / Q000627:therapeutic use; D003596:Cytosine / Q000031:analogs & derivatives / Q000627:therapeutic use; D004148:Dioxolanes / Q000627:therapeutic use; D051231:Farnesyltranstransferase / Q000037:antagonists & inhibitors; D006248:Harringtonines / Q000627:therapeutic use; D056572:Histone Deacetylase Inhibitors; D000077863:Homoharringtonine; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy*; D010087:Oxides / Q000627:therapeutic use; D014611:Vaccination
D020533:Angiogenesis Inhibitors; D001152:Arsenicals; D004148:Dioxolanes; D006248:Harringtonines; D056572:Histone Deacetylase Inhibitors; D016898:Interferon-alpha; D010087:Oxides; C074908:troxacitabine; D000077863:Homoharringtonine; D003596:Cytosine; D051231:Farnesyltranstransferase; D000077237:Arsenic Trioxide