Iron oxide core oil-in-water emulsions as a multifunctional nanoparticle platform for tumor targeting and imaging.
Nanoemulsions are increasingly investigated for the delivery of hydrophobic drugs to improve their bioavailability or make their administration possible. In the current study, oil-in-water emulsions with three different mean diameters (30, 60, and 95 nm) were developed as a new multimodality nanoparticle platform for tumor targeting and imaging. To that aim, hydrophobically coated iron oxide particles were included in the soybean oil core of the nanoemulsions to enable their detection with magnetic resonance imaging (MRI), while the conjugation of a near infrared fluorophore allowed optical imaging. The accumulation of this novel nanocomposite in subcutaneous human tumors in nude mice was demonstrated with MRI and fluorescence imaging in vivo, and with Perl's staining of histological tumor sections ex vivo.
Translational and Molecular Imaging Institute, Department of Radiology, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1234, New York, NY 10029, USA.
Peter A
PA
Jarzyna
Torjus
T
Skajaa
Anita
A
Gianella
David P
DP
Cormode
Daniel D
DD
Samber
Stephen D
SD
Dickson
Wei
W
Chen
Arjan W
AW
Griffioen
Zahi A
ZA
Fayad
Willem J M
WJ
Mulder
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000378:metabolism; D045744:Cell Line, Tumor; D003287:Contrast Media / Q000737:chemistry / Q000378:metabolism; D016503:Drug Delivery Systems; D004655:Emulsions / Q000737:chemistry* / Q000378:metabolism; D005290:Ferric Compounds / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008422:Materials Testing; D051379:Mice; D008819:Mice, Nude; D053758:Nanoparticles / Q000737:chemistry*; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology; D009821:Oils / Q000737:chemistry* / Q000378:metabolism; D010316:Particle Size; D014867:Water / Q000737:chemistry* / Q000378:metabolism
D001672:Biocompatible Materials; D003287:Contrast Media; D004655:Emulsions; D005290:Ferric Compounds; D009821:Oils; D014867:Water; C000499:ferric oxide