Catalytic enantioselective addition of terminal alkynes to aromatic aldehydes using zinc-hydroxyamide complexes.
A mandelamide ligand, derived from (S)-mandelic acid and (S)-phenylethanamine, catalyzes the addition of aryl-, alkyl- and silyl-alkynylzinc reagents to aromatic and heteroaromatic aldehydes with good yields and good to high enantioselectivities.
Departament de Química Orgànica, Facultat de Química, Universitat de València, Dr. Moliner 50, E-46100-Burjassot, València, Spain.
Gonzalo
G
Blay
Luz
L
Cardona
Isabel
I
Fernández
Alícia
A
Marco-Aleixandre
M Carmen
MC
Muñoz
José R
JR
Pedro