Principles of general and regulatory proteolysis by AAA+ proteases in Escherichia coli.
General and regulated proteolysis in bacteria is crucial for cellular homeostasis and relies on high substrate specificity of the executing AAA+ proteases. Here we summarize the various strategies that tightly control substrate degradation from both sides: the generation of accessible degrons and their specific recognition by AAA+ proteases and cognate adaptor proteins.
Zentrum für Molekulare Biologie Heidelberg (ZMBH), DKFZ-ZMBH Alliance, Universität Heidelberg, Im Neuenheimer Feld 282, Heidelberg D-69120, Germany.
Ronny
R
Schmidt
Bernd
B
Bukau
Axel
A
Mogk
D000251:Adenosine Triphosphatases / Q000378:metabolism*; D055162:Biocatalysis; D002352:Carrier Proteins / Q000378:metabolism; D004926:Escherichia coli / Q000201:enzymology* / Q000378:metabolism; D029968:Escherichia coli Proteins / Q000378:metabolism*; D010447:Peptide Hydrolases / Q000378:metabolism*; D055550:Protein Stability; D011506:Proteins / Q000378:metabolism; D013379:Substrate Specificity
D002352:Carrier Proteins; C454820:ClpS protein, E coli; D029968:Escherichia coli Proteins; D011506:Proteins; D010447:Peptide Hydrolases; D000251:Adenosine Triphosphatases