Obesity: its influence on breast cancer susceptibility.
Obesity is an increasing worldwide epidemic. With an increased prevalence of obesity there is an increase in obesity-related cancers, such as breast cancer. Although reproductive and lifestyle choices are among the best-recognized risk factors for breast cancer, few of these can be modified readily by the individual. Obesity is unlike these other risk factors since it can be modified and controlled. Breast cancer prognosis is worse in patients who are obese, and epidemiological data suggests that obesity is a significant risk factor for postmenopausal breast cancer. Addressing the obesity epidemic, at both an individual and public health level, is expected to have a significant impact on breast cancer incidence and mortality.
Clegg
Deborah J
DJ
Department of Psychiatry, Obesity Research Center, Genome Research Institute, University of Cincinnati, Cincinnati, OH 45267, USA.
Heffelfinger
Sue C
SC