Bioactivity of flavonoids isolated from Lychnophora markgravii against Leishmania amazonensis amastigotes.
The bioactivity of the flavonoids pinostrobin (1), pinocembrin (2), tectochrysin (3), galangin 3-methyl ether (4), and tiliroside (5) isolated from Lychnophora markgravii aerial parts was investigated in vitro against amastigote stages of Leishmania amazonensis. The compounds were isolated by several chromatographic techniques and their chemical structures were established by ESI-MS and NMR spectroscopic data. The flavonoids 1 and 3 were the most active compounds; they markedly reduced the viability of Leishmania amastigotes.
Salvador
Marcos José
MJ
Curso de Farmácia, Instituto de Biologia, Departamento de Biologia Vegetal, Universidade Estadual de Campinas (UNICAMP), Caixa Postal 6109, CEP 13083-970, Campinas (SP), Brazil. mjsalvador@bol.com.br
Sartori
Fabiana Terezinha
FT
Sacilotto
Ana Claudia B C
AC
Pral
Elizabeth M F
EM
Alfieri
Silvia Celina
SC
Vichnewski
Walter
W
D000666:Amphotericin B / Q000494:pharmacology; D000818:Animals; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000494:pharmacology*; D019659:Asteraceae / Q000737:chemistry*; D044950:Flavanones / Q000737:chemistry; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D007891:Leishmania / Q000187:drug effects*; D008958:Models, Molecular
D000981:Antiprotozoal Agents; D044950:Flavanones; D005419:Flavonoids; C052083:tiliroside; D000666:Amphotericin B; C016063:pinocembrin; C411294:pinostrobin