Localization of fatty acid binding protein of epidermal type common to dendritic cells and presumptive macrophages in Peyer's patches and epithelial M cells of mouse intestine.
Fatty acid binding protein of epidermal type (E-FABP) was expressed/localized in most, if not all, populations of the dendritic cells in the subepithelial domes, follicles and interfollicular regions of Peyer's patches and presumptive macrophages in their germinal centers, and all M cells in the follicle-associated epithelium of mouse intestine. The immunoreactivity in both of the cell populations makes it easy to recognize the accumulation of DCs in the subepithelial domes in close proximity to the base of M cells, which is essential for luminal antigens to be transported to Peyer's patches. E-FABP may play some important roles in the mucosal immune reaction through Peyer's patches and associated structures.
Suzuki
Ryoji
R
Department of Anatomy, Akita University Graduate School of Medicine, 1-1-1, Hondo, Akita, 010-8543, Japan. rysuzuki@gipc.akita-u.ac.jp
Nourani
Mohammad Reza
MR
Saino-Saito
Sachiko
S
Abe
Hiroshi
H
Nochi
Tomonori
T
Kiyono
Hiroshi
H
Spener
Friedrich
F
Kondo
Hisatake
H
Owada
Yuji
Y
D000818:Animals; D003713:Dendritic Cells / Q000737:chemistry*; D004847:Epithelial Cells / Q000737:chemistry*; D050556:Fatty Acid-Binding Proteins / Q000032:analysis* / Q000378:metabolism; D007150:Immunohistochemistry; D007422:Intestines / Q000166:cytology; D008264:Macrophages / Q000737:chemistry*; D051379:Mice; D009363:Neoplasm Proteins / Q000032:analysis / Q000378:metabolism; D010581:Peyer's Patches / Q000276:immunology*; D014018:Tissue Distribution
C082667:Fabp5 protein, mouse; D050556:Fatty Acid-Binding Proteins; D009363:Neoplasm Proteins