A report of human herpesvirus 6-associated encephalitis in a solid organ transplant recipient and a review of previously published cases.
Human herpesvirus 6 (HHV-6) is a common pathogen among children, classically presenting as fever and rash that resolve without specific therapy (exanthem subitum or roseola infantum). Also identified as a pathogen in hematopoietic cell transplant and solid organ transplant (SOT) recipients, it has been recognized as a cause of limbic encephalitis, characterized by confusion and amnesia, with magnetic resonance imaging findings of T2 hyperintensity of the amygdala and hippocampus. We report a case of limbic encephalitis associated with HHV-6 infection in a liver transplant recipient, and we review previously reported cases of HHV-6 encephalitis in SOT recipients.
Division of Infectious Diseases, University of Pennsylvania, Philadelphia, PA 19146, USA. christopher.vinnard@uphs.upenn.edu
Christopher
C
Vinnard
Todd
T
Barton
Elliot
E
Jerud
Emily
E
Blumberg
D000998:Antiviral Agents / Q000627:therapeutic use; D018792:Encephalitis, Viral / Q000150:complications / Q000175:diagnosis* / Q000821:virology*; D015654:Herpesvirus 6, Human / Q000378:metabolism*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008107:Liver Diseases / Q000150:complications / Q000628:therapy / Q000821:virology; D016031:Liver Transplantation / Q000009:adverse effects; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D019349:Roseolovirus Infections / Q000150:complications* / Q000175:diagnosis* / Q000821:virology; D016896:Treatment Outcome
D000998:Antiviral Agents; D007166:Immunosuppressive Agents