Selenoprotein P, rather than glutathione peroxidase, as a potential marker of septic shock and related syndromes.
OBJECTIVE
Oxidative stress is involved in sepsis-related endothelium dysfunction. Selenoprotein-P (Sel-P), the main plasma selenoprotein, may have high antioxidant potential, and binds to endothelium. We hypothesize that, in septic shock, and similar syndromes such as systemic inflammatory response syndrome (SIRS), Sel-P binds massively to endothelium, causing a drop in Sel-P plasma concentration.


METHODS
Plasma Se, Sel-P and albumin concentrations, and glutathione peroxidase (GPx) activity were measured in patients with septic shock and SIRS with organ failure (S group, n = 7 and n = 3, respectively) admitted to the intensive care unit (ICU) and compared to non-SIRS patients (NS group, n = 11) and healthy volunteers (HV group, n = 7).


RESULTS
On ICU admission, plasma Sel-P concentrations were 70% lower in the S group than in the other groups [15 (10-26) vs. 44 (29-71) and 50 (45-53) nmol/l] and were lower in nonsurviving septic-shock patients. GPx activity did not differ between groups. Sel-P was significantly lower before ICU death in the 3 deceased patients of the S group (septic shock) than in the 3 patients of the non-SIRS group.


CONCLUSIONS
Early decrease in Sel-P plasma concentrations was specifically observed in septic shock and was similar in SIRS patients whereas GPx activity remained unchanged. Further studies are needed to determine whether Sel-P can be an early marker of septic shock linked to microvascular injury.
Forceville
X
X
Centre Hospitalier de Meaux, Hôpital Saint-Faron, Meaux, France. xforceville@invivo.edu
Mostert
V
V
Pierantoni
A
A
Vitoux
D
D
Le Toumelin
P
P
Plouvier
E
E
Dehoux
M
M
Thuillier
F
F
Combes
A
A
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000097:blood; D011379:Prognosis; D012643:Selenium / Q000097:blood / Q000172:deficiency; D051149:Selenoprotein P / Q000097:blood* / Q000172:deficiency; D012772:Shock, Septic / Q000097:blood*; D018746:Systemic Inflammatory Response Syndrome / Q000097:blood*; D013997:Time Factors
D015415:Biomarkers; D051149:Selenoprotein P; D005979:Glutathione Peroxidase; D012643:Selenium