[Importance of selective A1 agonists for the protection of brain and heart against injuring factors].
Powerful selective A1 agonist N6-cyclopentyladenosine (CPA) effectively protects the brain (upon decapitation) and the heart (upon intoxication by KCl or ethylen glycol tetra acetate (EGTA)) against the action of injuring factors on experimental animals. CPA weakens or removes damages and/or cell death and probably promotes the regeneration of tissue structures and restoration of their functions. Thus, CPA increases the tolerance of the heart and brain with respect to the introduction of two strong toxicants and even upon decapitation. CPA and 5'-N-ethyl carboxamide adenosine (NECA) induce profound hypothermia, which also takes part in the protection. Selective agonists exhibit two different protective effects against injuring factors.
Minakina
L N
LN
Kulinskiĭ
V I
VI
D000241:Adenosine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D001927:Brain Diseases / Q000139:chemically induced / Q000517:prevention & control*; D002614:Chelating Agents / Q000009:adverse effects* / Q000494:pharmacology; D004533:Egtazic Acid / Q000009:adverse effects* / Q000494:pharmacology; D006331:Heart Diseases / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D051379:Mice; D011189:Potassium Chloride / Q000009:adverse effects* / Q000493:pharmacokinetics; D058906:Purinergic P1 Receptor Agonists
D002614:Chelating Agents; D058906:Purinergic P1 Receptor Agonists; C048599:N(6)-cyclopentyladenosine; D004533:Egtazic Acid; D011189:Potassium Chloride; D000241:Adenosine