Significance of urinary liver-fatty acid-binding protein in cardiac catheterization in patients with coronary artery disease.
OBJECTIVE
We investigated the significance of urinary liver fatty acid-binding protein (U-L-FABP) monitoring during cardiac catheterization in patients with cardiovascular disease (CVD). Methods The subjects included 27 consecutive patients with stable angina (SAP group) or acute coronary syndrome (ACS group) who had undergone successful percutaneous coronary intervention (PCI), and 12 patients were also enrolled as controls (C group). Urinary and serum parameters were measured immediately before and after and 1 day after PCI.


RESULTS
The ratio of U-L-FABP to U-creatinine (U-Cr) (U-L-FABP/U-Cr) in the ACS group was significantly higher than those in both the SAP and C groups before PCI. In addition, none of the patients in the SAP group showed contrast-induced nephropathy (CIN) based on the levels of serum (S)-Cr and U-L-FABP/U-Cr after PCI. Although none of the patients in the ACS group showed CIN according to S-Cr, the level of U-L-FABP/U-Cr was continuously high throughout the study period. Moreover, since there were significant differences in U-L-FABP/U-Cr, U-N-acetyl-beta-D-glucosaminidase, S-uric acid and % medication with calcium channel blockers before PCI between the ACS and SAP groups, a multiple regression analysis was performed using these parameters. It showed that U-L-FABP/U-Cr was most closely associated with the classification of SAP and ACS (p<0.0001). The cut-off level for the greatest sensitivity and specificity for U-L-FABP for the diagnosis of ACS was 13.4 microg/g. Cr in all subjects (sensitivity 0.800, specificity 0.963).


CONCLUSIONS
To the best of our knowledge, this is the first report indicating that the measurement of U-L-FABP can be beneficial for in the diagnosis of ACS.
Department of Cardiology, Fukuoka University School of Medicine, Fukuoka.
Yusuke
Y
Fukuda
Shin-ichiro
S
Miura
Bo
B
Zhang
Atsushi
A
Iwata
Akira
A
Kawamura
Hiroaki
H
Nishikawa
Kazuyuki
K
Shirai
Keijiro
K
Saku
D054058:Acute Coronary Syndrome / Q000175:diagnosis / Q000652:urine; D000368:Aged; D000369:Aged, 80 and over; D000787:Angina Pectoris / Q000175:diagnosis / Q000652:urine; D015906:Angioplasty, Balloon, Coronary; D015415:Biomarkers / Q000652:urine; D006328:Cardiac Catheterization; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy / Q000652:urine*; D003404:Creatinine / Q000652:urine; D050556:Fatty Acid-Binding Proteins / Q000652:urine*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity
D015415:Biomarkers; D050556:Fatty Acid-Binding Proteins; D003404:Creatinine