Innate immune recognition in tuberculosis infection.
In this review, an overview of the host's innate immune response against Mycobacterium tuberculosis will be provided. In particular, M. tuberculosis interaction with Toll-like receptors (TLRs), lung surfactant proteins and the antimicrobial mechanisms in the macrophage will be discussed along with their importance in shaping adaptive immunity to tuberculosis infection.
Division of Biosciences, School of Health Sciences and Social Care, Brunel University, Uxbridge, London, UK. anthony.tsolaki@brunel.ac.uk
Anthony G
AG
Tsolaki
D000818:Animals; D016207:Cytokines / Q000276:immunology / Q000378:metabolism; D003713:Dendritic Cells / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D054884:Host-Pathogen Interactions / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D037181:Lectins, C-Type / Q000276:immunology / Q000378:metabolism; D000090323:Mannose Receptor; D037241:Mannose-Binding Lectins / Q000276:immunology / Q000378:metabolism; D009169:Mycobacterium tuberculosis / Q000276:immunology; D010587:Phagocytosis / Q000276:immunology; D010588:Phagosomes / Q000276:immunology / Q000382:microbiology; D011956:Receptors, Cell Surface / Q000276:immunology / Q000378:metabolism; D011951:Receptors, Complement / Q000276:immunology / Q000378:metabolism; D051116:Receptors, Scavenger / Q000276:immunology / Q000378:metabolism; D051193:Toll-Like Receptors / Q000276:immunology* / Q000378:metabolism; D014376:Tuberculosis / Q000276:immunology* / Q000378:metabolism
D016207:Cytokines; D037181:Lectins, C-Type; D000090323:Mannose Receptor; D037241:Mannose-Binding Lectins; D011956:Receptors, Cell Surface; D011951:Receptors, Complement; D051116:Receptors, Scavenger; D051193:Toll-Like Receptors