Tissue reaction of the rat urinary bladder to synthetic mesh materials.
The aim of this study was to assess urinary bladder histopathology induced by the sling materials tension-free vaginal tape (TVT), vypro mesh, and intravaginal slingplasty (IVS). Thirty rats were studied: sham-operated controls, TVT, vypro, and IVS groups. After laparotomy, a 0.5- "e 1-cm piece of mesh was implanted on the anterior bladder wall. The bladder was examined histopathologically after 12 weeks. Inflammation, foreign-body reaction, subserosal fibrosis, necrosis, and collagen deposition were graded. The Kruskal-Wallis and posthoc Dunn tests were used. The sham-operated rats showed no tissue reactions. The TVT, vypro, and IVS groups showed increased inflammation (p = 0.006, p = 0.031, p = 0.001), subserosal fibrosis (p = 0.0001), foreign-body reaction (p = 0.0001), and collagen deposition (p = 0.0001) as compared to sham. Inflammation was more intense in the IVS group as compared to the TVT and vypro groups (p = 0.041, p = 0.028). The bladder presented more increased inflammatory response to IVS than the other meshs. This may play a role in the ultimate outcomes or complications from slings.
1st Urology Department, Sisli Etfal Research and Training Hospital, 34377 Istanbul, Turkey. gokhanatis@hotmail.com
Gokhan
G
Atis
Serdar
S
Arisan
Aysim
A
Ozagari
Turhan
T
Caskurlu
Ayhan
A
Dalkilinc
Erbil
E
Ergenekon
D000818:Animals; D005355:Fibrosis / Q000209:etiology; D020007:Implants, Experimental; D007249:Inflammation / Q000209:etiology*; D008297:Male; D008422:Materials Testing; D009336:Necrosis / Q000209:etiology; D019736:Prostheses and Implants; D051381:Rats; D053825:Suburethral Slings / Q000009:adverse effects; D013526:Surgical Mesh / Q000009:adverse effects*; D001743:Urinary Bladder / Q000187:drug effects / Q000473:pathology / Q000601:surgery*