Compliance with multiple-dose vaccine schedules among older children, adolescents, and adults: results from a vaccine safety datalink study.
OBJECTIVE
We studied compliance with multiple-dose vaccine schedules, assessed factors associated with noncompliance, and examined timeliness of series completion among older children, adolescents, and adults.


METHODS
We conducted a large, multisite, retrospective cohort study of older children, adolescents, and adults in the Vaccine Safety Datalink population from 1996 through 2004. We quantified the rates of completion of all required doses for varicella, hepatitis A, and hepatitis B vaccines according to their recommended schedules.


RESULTS
Among those who received a first dose of varicella (n = 16 075), hepatitis A (n = 594 917), and hepatitis B (n = 590 445) vaccine, relatively few completed the series (55%-65% for hepatitis B vaccine and 40%-50% for hepatitis A and varicella vaccines in most age groups). Compliance was lowest among adolescents (35.9%) and Medicaid recipients (29.7%) who received varicella vaccine and among younger adult age groups who received hepatitis A vaccine (25%-35% across those age groups). Even among series completers, there was a relatively long interval of undervaccination between the first and last doses.


CONCLUSIONS
Compliance with multiple-dose vaccine series among older children, adolescents, and adults is suboptimal. Further evaluations of strategies to improve compliance in these populations are needed.
Group Health Research Institute, Seattle, WA, USA. nelson.jl@ghc.org
Jennifer C
JC
Nelson
Rachel C L
RC
Bittner
Lora
L
Bounds
Shanshan
S
Zhao
James
J
Baggs
James G
JG
Donahue
Simon J
SJ
Hambidge
Steven J
SJ
Jacobsen
Nicola P
NP
Klein
Allison L
AL
Naleway
Kenneth M
KM
Zangwill
Lisa A
LA
Jackson
D000293:Adolescent; D000328:Adult; D019433:Chickenpox Vaccine / Q000008:administration & dosage*; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D004334:Drug Administration Schedule; D005260:Female; D022362:Hepatitis A Vaccines / Q000008:administration & dosage*; D017325:Hepatitis B Vaccines / Q000008:administration & dosage*; D006801:Humans; D017589:Immunization Programs / Q000592:standards*; D008297:Male; D008484:Medicaid; D055118:Medication Adherence; D008875:Middle Aged; D012189:Retrospective Studies; D014481:United States; D055815:Young Adult
D019433:Chickenpox Vaccine; D022362:Hepatitis A Vaccines; D017325:Hepatitis B Vaccines