Application of fragment growing and fragment linking to the discovery of inhibitors of Mycobacterium tuberculosis pantothenate synthetase.
Department of Chemistry, University of Cambridge, UK.
Alvin W
AW
Hung
H Leonardo
HL
Silvestre
Shijun
S
Wen
Alessio
A
Ciulli
Tom L
TL
Blundell
Chris
C
Abell
D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008958:Models, Molecular; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000201:enzymology*; D010453:Peptide Synthases / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism; D011487:Protein Conformation; D013237:Stereoisomerism
D004791:Enzyme Inhibitors; D010453:Peptide Synthases; C022318:pantothenate synthetase