Preparation and characterization of novel gellan gum hydrogels suitable for modified drug release.
Innovative hydrogels obtained by physical and chemical crosslinking of deacylated Gellan gum have been characterized in terms of water uptake, rheological properties and compressibility, and the behaviour of the tested materials, according to the type of the obtained network, is thoroughly discussed. The release from the various gels of loaded model molecules of different steric hindrance was also investigated and the trend of the release profiles has been related to the structures proposed for the physical and the chemical hydrogel.
Matricardi
Pietro
P
Department of Drug Chemistry and Technologies, Faculty of Pharmacy, University of Rome La Sapienza, Piazzale Aldo Moro 5, 00185, Rome, Italy. pietro.matricardi@uniroma1.it
Cencetti
Claudia
C
Ria
Roberto
R
Alhaique
Franco
F
Coviello
Tommasina
T
D003432:Cross-Linking Reagents / Q000737:chemistry; D003911:Dextrans / Q000737:chemistry; D016503:Drug Delivery Systems; D016650:Fluorescein-5-isothiocyanate / Q000737:chemistry; D020100:Hydrogels / Q000138:chemical synthesis* / Q000737:chemistry*; D055595:Mechanical Phenomena; D011135:Polysaccharides, Bacterial / Q000737:chemistry*; D012212:Rheology; D013696:Temperature; D014805:Vitamin B 12 / Q000737:chemistry; D014867:Water / Q000737:chemistry
D003432:Cross-Linking Reagents; D003911:Dextrans; D020100:Hydrogels; D011135:Polysaccharides, Bacterial; D014867:Water; C048288:gellan gum; D016650:Fluorescein-5-isothiocyanate; D014805:Vitamin B 12