Late-life reactivation of obsessive-compulsive disorder associated with lesions in prefrontal-subcortical circuits.
The authors describe the reactivation of obsessive-compulsive disorder (OCD) in three patients with lesions in the prefronto-subcortical circuits after decades of being asymptomatic. The patients also reported the emergence of new OCD symptoms and motor/phonic tics as well as mental rituals thematically related to the negative experience of suffering cognitive and motor deficits.
Florida Institute of Technology, Melbourne, FL, USA.
Christine
C
Salinas
Guadalupe
G
Dávila
Marcelo L
ML
Berthier
Cristina
C
Green
J Pablo
JP
Lara
D000367:Age Factors; D000368:Aged; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009434:Neural Pathways / Q000000981:diagnostic imaging / Q000473:pathology; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy / Q000473:pathology*; D017397:Prefrontal Cortex / Q000000981:diagnostic imaging / Q000473:pathology*; D011569:Psychiatric Status Rating Scales; D011619:Psychotropic Drugs / Q000627:therapeutic use; D012008:Recurrence; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
D011619:Psychotropic Drugs