[Cytomegalovirus infection and disease in pediatric solid organ transplantation. Experience in a Chilean multiorganic transplantation center].
Cytomegalovirus (CMV) infection and disease in transplant (Tx) recipients may severely complicate the patients outcome.


OBJECTIVE
To determine the incidence, clinical characteristics and risk factors for CMV infection and disease in liver and kidney transplant recipients in a tertiary care children's hospital.


METHODS
A clinical and laboratory evaluation was prospectively performed in 44 and 20 children receiving a renal and liver Tx respectively in the Hospital Luis Calvo Mackenna between 2004 and 2006.


RESULTS
At the time of the organ Tx 20.3% (13/64) children were seronegative for CMV. Thirty six per cent (23/64) patients were infected with CMV, of whom 32% (14/44) received kidney Tx and 9/20 (45%) received liver Tx. CMV disease occurred in 52% (12/23) of infected patients. CMV disease was characterized by fever (100%), anemia (50%), leucopenia (16.6%) and specific organ involvement (renal graft 60% liver graft 57.1%, lung 25%, intestine 16.6%). Variables significantly associated with infection were a CMV seronegative status (p = 0.035) and lower age 5.5 + 3.7 years old vs 8.3 + 4.4 years old (p = 0.01).


CONCLUSIONS
Incidence of CMV infection was high in children receiving a solid organ transplant in our institution and near half of infected children developed CMV-associated disease.
Hospital Luis Calvo Mackenna, Santiago, Chile. paulyse@yahoo.com
M Paulina
MP
Salazar E
Andrea
A
Alba G
Angela
A
Deluchi B
Bessie
B
Hunter M
Jorge
J
Godoy L
Mario
M
Ferrario B
Mario
M
Uribe M
Erwin
E
Buckel G
D000293:Adolescent; D000998:Antiviral Agents / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D003586:Cytomegalovirus Infections / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology; D015774:Ganciclovir / Q000627:therapeutic use; D006801:Humans; D016867:Immunocompromised Host; D015994:Incidence; D007223:Infant; D016030:Kidney Transplantation; D016031:Liver Transplantation; D011446:Prospective Studies; D012307:Risk Factors
D000998:Antiviral Agents; D015774:Ganciclovir