[Efficacy and safety of cyclosporin A withdrawal in children long after kidney transplantation].
OBJECTIVE
Evaluation of cyclosporine (CSA) withdrawal safety and efficacy in children late after kidney transplantation.


METHODS
Graft and patient survival was analysed in 30 kidney recipients operated in the central children's hospital in 1991-1999. Fifteen of 30 patients came for follow-up to the Russian Research Center for Surgery where CsA was withdrawn 6.8 +/- 2.7 after transplantation. The other 15 children continued immunosuppression with CsA.


RESULTS
Higher graft survival was observed in children in whom CsA was discontinued.


CONCLUSIONS
Discontinuation of cyclosporine late after kidney transplantation results in improvement of graft survival in most of the patients.
Kaabak
M M
MM
Babenko
N N
NN
Molchanova
E A
EA
Zokoev
A K
AK
Kurakina
Zh I
ZhI
Goriaĭnov
V A
VA
Minina
M G
MG
Akhmetshin
R B
RB
D000293:Adolescent; D016572:Cyclosporine / Q000008:administration & dosage* / Q000627:therapeutic use; D016208:Databases, Factual; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000453:epidemiology / Q000401:mortality / Q000517:prevention & control*; D006085:Graft Survival / Q000187:drug effects*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D053208:Kaplan-Meier Estimate; D016030:Kidney Transplantation; D009173:Mycophenolic Acid / Q000008:administration & dosage / Q000627:therapeutic use; D013997:Time Factors
D007166:Immunosuppressive Agents; D016572:Cyclosporine; D009173:Mycophenolic Acid