Steroidal glycosides from Furcraea foetida and their cytotoxic activity.
Two new spirostanol glycosides (1, 2) and a new furostanol glycoside (3), together with nine known steroidal glycosides (4-12) were isolated from the leaves of Furcraea foetida (Agavaceae). The structures of the new compounds were determined by spectroscopic analysis and the results of hydrolytic cleavage. The isolated compounds were evaluated for their cytotoxic activities against HL-60 human leukemia cells, A549 human lung adenocarcinoma cells, HSC-2 human oral squamous carcinoma cells, and HSC-4 human oral squamous carcinoma cells.
Yokosuka
Akihito
A
Laboratory of Medicinal Pharmacognosy, Tokyo University of Pharmacy and Life Sciences School of Pharmacy, Hachiouji, Tokyo 192-0392, Japan. yokosuka@toyaku.ac.jp
Sano
Tomoe
T
Hashimoto
Ken
K
Sakagami
Hiroshi
H
Mimaki
Yoshihiro
Y
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D000070357:Asparagaceae / Q000737:chemistry*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D018922:HL-60 Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D013150:Spirostans / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity
C545787:(23S,25R)-6alpha-((beta-D-glucopyranosyl)oxy)-23-hydroxy-5alpha-spirostan-3beta -yl beta -D-fucopyranoside; D000972:Antineoplastic Agents, Phytogenic; D006027:Glycosides; D013150:Spirostans