Oncologic outcome after extraperitoneal laparoscopic radical prostatectomy: midterm follow-up of 1115 procedures.
BACKGROUND
Although the first laparoscopic radical prostatectomy was performed in 1997, few midterm oncologic data have been published for the extraperitoneal procedure.


OBJECTIVE
To determine the oncologic outcome of extraperitoneal laparoscopic radical prostatectomy (ELRP).


METHODS
From 2000 to 2007, 1115 consecutive patients underwent ELRP for a localized prostate cancer at our department. Follow-up was scheduled and standardized for all patients and recorded into a prospective database. Median postoperative follow-up was 35.6 mo.


METHODS
All ELRP were performed by three surgeons at the Department of Urology, Hospital Henri Mondor, Créteil, France.


METHODS
Biochemical recurrence was defined by prostate-specific antigen level > or =0.2 ng/ml.


CONCLUSIONS
In pN0/pNx cancers, postoperative stage was pT2 in 664 patients (59.5%), pT3 in 350 patients (31.4%), and pT4 in 77 patients (6.9%). Positive lymph nodes were reported in 24 patients (2.2%). Margins were positive in 16.1% and 34.6% of pT2 and pT3 cancers, respectively. Final Gleason score was <7 in 288 men (25.8%), =7 in 701 men (62.9%), and >7 in 126 men (11.3%). Overall prostate-specific antigen (PSA) recurrence-free survival was 83% at 5 yr. The 5-yr progression-free survival rates were 93.4% for pT2, 74.5% for pT3a, and 55.0% for pT3b tumors, respectively. Multivariate Cox model showed that PSA, Gleason score, pT category, nodal status, and surgical margins were significant independent predictors of biochemical recurrence-free survival.


CONCLUSIONS
This assessment of oncologic results demonstrates that ELRP is a safe and effective procedure. On the basis of midterm follow-up data, the prognostic factors of PSA after ELRP failure are the same as those described previously in transperitoneal or open retropubic approaches. The oncologic results of ELRP also are in line with those reported with the use of the retropubic or the transperitoneal laparoscopic approaches.
Paul
Alexandre
A
INSERM U955 EQ7, Departments of Urology and Pathology APHP, CHU Henri Mondor, Créteil, France.
Ploussard
Guillaume
G
Nicolaiew
Nathalie
N
Xylinas
Evanguelos
E
Gillion
Norman
N
de la Taille
Alexandre
A
Vordos
Dimitri
D
Hoznek
Andras
A
Yiou
René
R
Abbou
Claude Clément
CC
Salomon
Laurent
L
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005500:Follow-Up Studies; D006801:Humans; D010535:Laparoscopy; D008297:Male; D008875:Middle Aged; D010537:Peritoneum; D011468:Prostatectomy / Q000379:methods*; D011471:Prostatic Neoplasms / Q000473:pathology / Q000601:surgery*; D013997:Time Factors; D016896:Treatment Outcome