The role of proteolysis in the Caulobacter crescentus cell cycle and development.
Caulobacter crescentus cell cycle progression is implemented by oscillating global transcriptional regulators that establish temporal and spatial control of modular genetic subsystems during the cell cycle. The hierarchy of this regulatory circuit is established through a combination of gene expression control and regulated proteolysis. Recent results highlight the importance of spatial organization for controlled proteolysis in C. crescentus.
Jenal
Urs
U
Biozentrum of the University of Basel, Klingelbergstrasse 50/70, CH-4056 Basel, Switzerland. urs.jenal@unibas.ch
D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D055162:Biocatalysis; D016935:Caulobacter crescentus / Q000201:enzymology* / Q000235:genetics / Q000254:growth & development; D002453:Cell Cycle; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D015964:Gene Expression Regulation, Bacterial; D049070:Protease La / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism
D001426:Bacterial Proteins; C097706:CtrA protein, Caulobacter; D004268:DNA-Binding Proteins; C066312:DnaA protein, Bacteria; D014157:Transcription Factors; D049070:Protease La