Pathophysiology and management of the burn scar.
Fibroproliferative disorders (FPDs) are common and serious disorders. Hypertrophic scar (HSc) and keloids represent the dermal equivalents of FPD and impose lower mortality but great morbidity. This article reviews current knowledge in the pathophysiology and molecular and cellular characteristics of postburn HSc. Additionally, current treatment modalities and future treatment options based on advancements in the understanding of the pathophysiology of HSc are discussed.
Ladak
Adil
A
Department of Surgery, University of Alberta, Edmonton, Canada.
Tredget
Edward E
EE
D001854:Bone Marrow Cells / Q000473:pathology; D002056:Burns / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy*; D002921:Cicatrix / Q000503:physiopathology / Q000628:therapy; D017439:Cicatrix, Hypertrophic / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery* / Q000628:therapy; D005355:Fibrosis; D006801:Humans; D007249:Inflammation; D016896:Treatment Outcome