Transcription dynamics.
All aspects of transcription and its regulation involve dynamic events. The basal transcription machinery and regulatory components are dynamically recruited to their target genes, and dynamic interactions of transcription factors with chromatin--and with each other--play a key role in RNA polymerase assembly, initiation, and elongation. These short-term binding dynamics of transcription factors are superimposed by long-term cyclical behavior of chromatin opening and transcription factor-binding events. Its dynamic nature is not only a fundamental property of the transcription machinery, but it is emerging as an important modulator of physiological processes, particularly in differentiation and development.
National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. hagerg@mail.nih.gov
Gordon L
GL
Hager
James G
JG
McNally
Tom
T
Misteli
D000818:Animals; D001665:Binding Sites; D002467:Cell Nucleus / Q000201:enzymology / Q000378:metabolism*; D002843:Chromatin / Q000378:metabolism; D042002:Chromatin Assembly and Disassembly; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism; D005786:Gene Expression Regulation; D023281:Genomics / Q000379:methods; D006801:Humans; D007700:Kinetics; D046912:Multiprotein Complexes; D012313:RNA / Q000096:biosynthesis*; D014157:Transcription Factors / Q000378:metabolism; D014158:Transcription, Genetic
D002843:Chromatin; D046912:Multiprotein Complexes; D014157:Transcription Factors; D012313:RNA; D012321:DNA-Directed RNA Polymerases