[Search of novel bioactive natural products from plant sources--novel structures and biological activities--].
Over 30 years, our laboratory has been involved in the search of bioactive natural products from plant sources of several plant families, Rutaceae, Guttiferae, Avicenniaceae, and so on. In this review, novel structures of acridone alkaloids, carbazole alkaloids, coumarins, depsidones, and so on isolated in our laboratory will be showed. In addition, some results of assay of biological activities of the isolated compounds also will be described.
Faculty of Pharmacy, Meijo University, Nagoya, Japan. fhiro@quartz.ocn.ne.jp
Hiroshi
H
Furukawa
D054831:Acridones / Q000737:chemistry / Q000302:isolation & purification*; D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification*; D000818:Animals; D000970:Antineoplastic Agents; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification; D053630:Depsides / Q000302:isolation & purification / Q000494:pharmacology; D055808:Drug Discovery; D018922:HL-60 Cells / Q000473:pathology; D006801:Humans; D007783:Lactones / Q000302:isolation & purification / Q000494:pharmacology; D015473:Leukemia, Promyelocytic, Acute / Q000473:pathology; D051379:Mice; D009569:Nitric Oxide / Q000378:metabolism; D027821:Rutaceae / Q000737:chemistry*; D012878:Skin Neoplasms / Q000473:pathology; D044004:Xanthones / Q000302:isolation & purification / Q000494:pharmacology
D054831:Acridones; D000470:Alkaloids; D000970:Antineoplastic Agents; D003374:Coumarins; D053630:Depsides; D007783:Lactones; D044004:Xanthones; D009569:Nitric Oxide; C000875:depsidone; C009689:xanthone