Role of adipocytokines in predicting the development of diabetes and its late complications.
Diabetes is an important health problem since the incidence of diabetes is continuously increasing. Early diagnosis is important as type 2 diabetes begins long before we diagnose it, leading to a complicated course of the disease. In order to prevent delay in the diagnosis of type 2 diabetes, novel predictors and pathways for type 2 diabetes are mounting. Diabetic complications are common cause of morbidity and mortality among subjects with diabetes. In the pathogenesis of diabetic complications some factors other than chronic hyperglycemia may be involved. Adipocytokines play important roles in the pathogenesis of diabetes mellitus, insulin resistance, and associated metabolic conditions such as hypertension and dyslipidemia. The investigations on the role of adipocytokines in developing diabetes and its complications have been made. In this review, we discussed the implications of adipocytokines in predicting diabetes and diabetic complications, with particular attention on the roles of adiponectin, leptin, visfatin, and vaspin.
Gulcelik
Nese Ersoz
NE
Department of Endocrinology and Metabolism, Hacettepe University Medical School, Sıhhıye, Ankara, Turkey.
Usman
Aydan
A
Gürlek
Alper
A
D054392:Adipokines / Q000097:blood / Q000502:physiology*; D052242:Adiponectin / Q000032:analysis / Q000097:blood / Q000502:physiology; D017668:Age of Onset; D016207:Cytokines / Q000032:analysis / Q000097:blood / Q000502:physiology; D048909:Diabetes Complications / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D003940:Diagnostic Techniques, Endocrine; D006801:Humans; D020738:Leptin / Q000032:analysis / Q000097:blood / Q000502:physiology; D054409:Nicotinamide Phosphoribosyltransferase / Q000032:analysis / Q000097:blood / Q000502:physiology; D011379:Prognosis; D015843:Serpins / Q000032:analysis / Q000097:blood / Q000502:physiology
D054392:Adipokines; D052242:Adiponectin; D016207:Cytokines; D020738:Leptin; C507339:SERPINA12 protein, human; D015843:Serpins; D054409:Nicotinamide Phosphoribosyltransferase; C085455:nicotinamide phosphoribosyltransferase, human