Platelet transcriptome and cardiovascular disease.
Platelet hyper-reactivity is likely to play a role in cardiovascular disease, but there are no standardized tests to evaluate platelet responsiveness. A 'platelet chip' (a synthetic oligonucleotide microarray representing all platelet-restricted genes) is under development as a tool for high-throughput characterization of platelet-based bleeding and clotting disorders. In future, platelet gene profiling may be used to improve thrombohemorrhagic risk assessment and to guide antiplatelet therapy for patients at risk of cardiovascular disease.
Senzel
Lisa
L
State University of New York, Department of Pathology, Stony Brook, NY, USA. lsenzel@notes.cc.sunysb.edu
Gnatenko
Dmitri V
DV
Bahou
Wadie F
WF