Durable hypogammaglobulinemia associated with thymoma (Good syndrome).
Good syndrome, characterized by hypogammaglobulinemia and acquired immunodeficiency, is a rare condition associated with thymoma. A 67-year-old woman, who 4 months previously had a thymoma resected, presented with generalized hypogammaglobulinemia with a severely decreased B cell population as demonstrated by flow cytometry. She was diagnosed as having bacterial mediastinitis associated with Good syndrome. For the subsequent 6 years, she suffered from repeated serious bacterial infections. As this paraneoplastic syndrome is not resolved by tumor removal, careful management with intensive infection-control using antibiotics and intravenous immunoglobulins is required for the long term. Serum immunoglobulin levels should be evaluated for patients with thymoma and suspected vulnerability to infection.
Department of Respirology, Graduate School of Medicine, Chiba University, Chiba.
Atsushi
A
Kitamura
Yuichi
Y
Takiguchi
Naobumi
N
Tochigi
Shun-ichi
S
Watanabe
Seiichirou
S
Sakao
Katsushi
K
Kurosu
Nobuhiro
N
Tanabe
Koichiro
K
Tatsumi
D000361:Agammaglobulinemia / Q000150:complications* / Q000276:immunology; D000368:Aged; D001402:B-Lymphocytes / Q000276:immunology; D005260:Female; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000150:complications / Q000276:immunology; D008231:Lymphopenia / Q000150:complications / Q000276:immunology; D010257:Paraneoplastic Syndromes / Q000150:complications / Q000276:immunology; D013577:Syndrome; D013945:Thymoma / Q000150:complications* / Q000175:diagnosis / Q000276:immunology; D013953:Thymus Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000276:immunology; D013997:Time Factors