Physical forces in myelination and repair: a question of balance?
A recent report in BMC Cell Biology examines how the balance of extracellular forces and intracellular contractions regulate the shape changes required for oligodendrocyte myelination. A failure of remyelination such as seen in multiple sclerosis could be caused by loss of this balance.
Bauer
Nina G
NG
MRC Centre for Regenerative Medicine, Centre for Multiple Sclerosis Research, The University of Edinburgh, Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK. nina.g.bauer@ed.ac.uk
ffrench-Constant
Charles
C
D000818:Animals; D002448:Cell Adhesion; D048430:Cell Shape; D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D040542:Mechanotransduction, Cellular; D009103:Multiple Sclerosis / Q000473:pathology*; D009186:Myelin Sheath / Q000502:physiology*; D012038:Regeneration