Highly enantioselective synthesis of angelmarin.
Angelmarin (1), a novel anti-cancer agent, was efficiently synthesized through a highly enantioselective epoxidation and a copper cyanide-mediated esterification of the hindered alcohol as the key steps in 53% overall yield.
Jiang
Hang
H
Hamada
Yasumasa
Y
D001688:Biological Products / Q000138:chemical synthesis / Q000737:chemistry; D003374:Coumarins / Q000138:chemical synthesis* / Q000737:chemistry*; D010936:Plant Extracts / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism; D013379:Substrate Specificity
D001688:Biological Products; D003374:Coumarins; D010936:Plant Extracts; C508941:angelmarin