Disease progression in HIV-1-infected patients heterozygous for the sickle hemoglobin gene.
The sickle cell trait-asymptomatic carriage is frequent in people originating from sub-Saharan Africa. Several host factors (including sickle cell anemia) have been previously reported to act upon the course of HIV disease. We studied the progression of infection in a cohort of African patients heterozygous for the sickle hemoglobin gene and harboring normal hemoglobin genes. No significant difference was evidenced between the two groups from this preliminary study.
Sellier
Pierre
P
Department of Internal Medicine and Infectious Diseases, Lariboisière Hospital, Paris, France.
Masson
Elisabeth
E
Zini
Jean-M
JM
Simoneau
Guy
G
Magnier
Jean-D
JD
Evans
John
J
Bergmann
Jean-F
JF
D000328:Adult; D017954:Africa South of the Sahara / Q000453:epidemiology; D000755:Anemia, Sickle Cell / Q000453:epidemiology / Q000235:genetics*; D018450:Disease Progression; D005260:Female; D015497:HIV-1; D006451:Hemoglobin, Sickle / Q000235:genetics*; D006579:Heterozygote; D006801:Humans; D008297:Male
D006451:Hemoglobin, Sickle