Improving powder flow properties of a cohesive lactose monohydrate powder by intensive mechanical dry coating.
The objective of this study was to improve the cohesive lactose powder flowability. A cohesive lactose monohydrate powder was processed in either a tumbling blender or an intensive mechanical processor with either magnesium stearate or fumed silica. No substantial changes in particle size were detected by laser diffraction following either treatment. The untreated lactose sample exhibited very poor powder flow. Only limited improvements in powder flowability were indicated after the tumbling blending, intensive mechanical processing with the fumed silica or without additives. However, the intensive mechanical processing of the lactose sample with magnesium stearate demonstrated exceptionally large increases in both poured and tapped density as well as notable improvements in all powder flowability indicators examined. Our findings support the use of intensive mechanical processing technique as an effective method to coat cohesive pharmaceutical powders with selected additives, modify the surface nature of the particles, reduce the interparticle cohesive forces and hence improve powder flowability. The subtle differences in powder flow behaviour of lactose samples between the untreated and tumbling blended powders with magnesium stearate were only detected by the powder rheometer using its dynamic mode, indicating its potential advantages over traditional powder flow characterisation approaches.
Zhou
Qi
Q
Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.
Armstrong
Brian
B
Larson
Ian
I
Stewart
Peter J
PJ
Morton
David A V
DA
D000465:Algorithms; D002626:Chemistry, Pharmaceutical; D003890:Desiccation; D004339:Drug Compounding; D005079:Excipients / Q000737:chemistry*; D007785:Lactose / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D010316:Particle Size; D011208:Powders; D012212:Rheology; D013229:Stearic Acids / Q000737:chemistry
D005079:Excipients; D011208:Powders; D013229:Stearic Acids; C031183:stearic acid; D007785:Lactose