Ceftazidime in Gram-negative infections: three case reports.
Three patients with serious infections due to Gram-negative bacilli were treated with ceftazidime: a 52-year-old woman with Enterobacter cloacae meningitis, a 33-year-old woman with post-traumatic Pseudomonas aeruginosa mediastinitis and a 68-year-old man with myelomatosis and Ps. aeruginosa pneumonia. In all three cases the use of ceftazidime, in combination with gentamicin, resulted in clinical improvement associated with rapid clearing of the organism from infected sites. No haematological or biochemical abnormality attributable to ceftazidime was detected.
Regional Public Health Laboratory, Newcastle General Hospital, Newcastle upon Tyne, England.
J K
JK
Wardle
J B
JB
Selkon
H R
HR
Ingham
D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000097:blood / Q000627:therapeutic use*; D002442:Ceftazidime / Q000097:blood / Q000627:therapeutic use*; D002701:Chloramphenicol / Q000627:therapeutic use; D017809:Fatal Outcome; D005260:Female; D005839:Gentamicins / Q000627:therapeutic use; D016905:Gram-Negative Bacterial Infections / Q000097:blood / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications; D011018:Pneumonia, Pneumococcal / Q000150:complications / Q000188:drug therapy; D011183:Postoperative Complications / Q000188:drug therapy / Q000382:microbiology; D013345:Subarachnoid Hemorrhage / Q000150:complications; D013898:Thoracic Injuries / Q000188:drug therapy
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D002701:Chloramphenicol; D002442:Ceftazidime