Gestational age-specific cutoff levels of TDx-FLM II for the prediction of neonatal respiratory distress syndrome.
OBJECTIVE
To construct a predictive model for respiratory distress syndrome (RDS) from gestational age (GA) at delivery and TDx-FLM II value.


METHODS
Pregnant women who underwent an amniocentesis in which TDx-FLM II was determined were included in the study. A model for the occurrence of RDS was constructed by means of a logistic regression procedure from TDx-FLM II values and GA at delivery.


RESULTS
The mean value of TDx-FLM II was 47.11 mg/g. The mean GA at delivery was 33.4 weeks. The incidence of RDS was 7.8% (18/231). The optimal cutoff of predicted risk for respiratory distress was found to be 8.8%, resulting in a sensitivity and specificity of 89 and 83%, respectively.


CONCLUSIONS
The adjustment of the TDx-FLM II value for GA at delivery results in a significant improvement in the predictive capacity of the test for the occurrence of RDS. The use of GA-specific cutoff values may simplify clinical decisions.
Department of Maternal-Fetal Medicine, Hospital Clínic, Institut d'Investigacions Biomèdiques Augusto Pi i Sunyer, University of Barcelona, and Centro de Investigación Biomédica en Red de Enfermedades Raras, Barcelona, Spain.
Mar
M
Bennasar
Francesc
F
Figueras
Montse
M
Palacio
Jordi
J
Bellart
Elena
E
Casals
Josep
J
Figueras
Oriol
O
Coll
Eduard
E
Gratacós
D000418:Albumins / Q000032:analysis*; D000649:Amniocentesis; D000653:Amniotic Fluid / Q000737:chemistry*; D005260:Female; D005325:Fetal Organ Maturity; D005454:Fluorescence Polarization; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D016015:Logistic Models; D008168:Lung / Q000196:embryology*; D008954:Models, Biological; D011237:Predictive Value of Tests; D011247:Pregnancy; D011663:Pulmonary Surfactants / Q000032:analysis*; D012372:ROC Curve; D012127:Respiratory Distress Syndrome, Newborn / Q000175:diagnosis* / Q000209:etiology / Q000378:metabolism; D018570:Risk Assessment; D012307:Risk Factors; D012680:Sensitivity and Specificity
D000418:Albumins; D011663:Pulmonary Surfactants