Antihistamine pretreatment to reduce incidence of withdrawal movement after rocuronium injection.
The purpose of this study was to determine the effectiveness of antihistamine therapy for withdrawal movements caused by rocuronium injection. One hundred seventy one ASA I-II adults undergoing elective surgery were randomly assigned to one of two groups. Patients in the control group (Group C) were premedicated with 2 mL normal saline, and those in the antihistamine group (Group A) were pre-medicated with 2 mL (45.5 mg) pheniramine maleate. After the administration of thiopental sodium 5 mg/kg, rocuronium 0.6 mg/kg was injected. Withdrawal movements were assessed using a four-grade scale. The administration of antihistamine reveals lower grade of withdrawal movement after rocuronium injection.
Lee
Ho Jun
HJ
Department of Anesthesiology and Pain Medicine, Guro Hospital, Korea University College of Medicine, Seoul, Korea.
Han
Sung Jin
SJ
Kim
Heezoo
H
Lee
Il Ok
IO
Kong
Myoung Hoon
MH
Kim
Nan Suk
NS
Lim
Sang Ho
SH
Lee
Mi Kyoung
MK
D000328:Adult; D000732:Androstanols / Q000008:administration & dosage* / Q000009:adverse effects; D018686:Anesthetics, Intravenous / Q000008:administration & dosage; D004311:Double-Blind Method; D005260:Female; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D006801:Humans; D015994:Incidence; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D009068:Movement / Q000187:drug effects / Q000502:physiology; D003473:Neuromuscular Nondepolarizing Agents / Q000008:administration & dosage* / Q000009:adverse effects; D010146:Pain / Q000139:chemically induced; D010147:Pain Measurement; D010632:Pheniramine / Q000494:pharmacology*; D000077123:Rocuronium; D013874:Thiopental / Q000008:administration & dosage
D000732:Androstanols; D018686:Anesthetics, Intravenous; D006634:Histamine H1 Antagonists; D003473:Neuromuscular Nondepolarizing Agents; D010632:Pheniramine; D013874:Thiopental; D000077123:Rocuronium