C-reactive protein 1059G>C genetic polymorphism influences serum C-reactive protein levels after esophagectomy in patients with thoracic esophageal cancer.
BACKGROUND
Little is known about how C-reactive protein (CRP) genetic polymorphisms influence the rise in serum CRP levels seen after surgery. The purpose of this study was to assess the association between CRP polymorphisms and acute-phase serum CRP levels after esophagectomy for thoracic esophageal cancer.


METHODS
We enrolled 110 patients who underwent curative esophagectomy without neoadjuvant treatment between 2003 and 2008. Using peripheral blood samples collected from the patients, polymorphisms for CRP, tumor necrosis factor, interferon-gamma, tumor growth factor-beta1, interleukin (IL)-1beta, IL-1 receptor antagonist, IL-2, IL-4, IL-6, IL-6 receptor, IL-10, and IL-12beta were all investigated to determine which, if any, affect postoperative serum CRP levels and clinical outcomes.


RESULTS
Although preoperative serum CRP levels did not differ, 12 hours after esophagectomy, serum CRP levels were significantly higher in patients carrying the CRP 1059G/G genotype than in those with the 1059G/C genotype (111 +/- 35 mg/L versus 78 +/- 17 mg/L; p = 0.0266), and after 36 hours CRP levels remained higher in those with the 1059G/G genotype (217 +/- 63 mg/L versus 140 +/- 51 mg/L; p = 0.0020). Logistic regression models revealed that patients carrying the CRP 1059G/G genotype had a significantly higher likelihood of a postesophagectomy increase in serum CRP, although the CRP 1059G>C genetic polymorphism had no effect on clinical outcomes. None of the other cytokine genetic polymorphisms influenced postoperative serum CRP levels.


CONCLUSIONS
Our findings suggest that the CRP 1059G>C genetic polymorphism is 1 determinant of serum CRP levels after major surgery.
Department of Surgery, Akita University School of Medicine, 1-1-1 Hondo, Akita, Japan.
Satoru
S
Motoyama
Masatomo
M
Miura
Yudai
Y
Hinai
Kiyotomi
K
Maruyama
Shuetsu
S
Usami
Toshinobu
T
Nakatsu
Hajime
H
Saito
Yoshihiro
Y
Minamiya
Toshio
T
Suzuki
Jun-ichi
J
Ogawa
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood* / Q000235:genetics*; D002097:C-Reactive Protein / Q000235:genetics* / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000378:metabolism; D003545:Cysteine; D016207:Cytokines / Q000097:blood / Q000235:genetics; D004938:Esophageal Neoplasms / Q000097:blood* / Q000473:pathology / Q000601:surgery*; D016629:Esophagectomy; D005260:Female; D005838:Genotype; D005998:Glycine; D006801:Humans; D016015:Logistic Models; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D020641:Polymorphism, Single Nucleotide; D011184:Postoperative Period
D014408:Biomarkers, Tumor; D016207:Cytokines; D002097:C-Reactive Protein; D003545:Cysteine; D005998:Glycine