Low serum osteoprotegerin levels in normoalbuminuric type 1 diabetes mellitus.
The aim of this study is to establish whether abnormal mineral metabolism is present in patients with type 1 DM with normal renal function and in the absence of microalbuminuria. Serum levels of 1,25-dihydroxyvitamin D, osteoprotegerin (OPG) and receptor activator for nuclear factor kappa β ligand (RANKL) and other determinants of bone metabolism were measured in 35 patients with type 1 DM and in 25 age-, sex- and ethnicity-matched healthy controls. Serum OPG (1.98 vs. 2.98 pmol/l: P = 0.001), 1,25-dihydroxyvitamin D (41.1 vs. 48.2 pmol/l: P = 0.035) and magnesium (0.84 vs. 0.89 mmol/l P = 0.029) levels were significantly lower in patients with type 1 DM compared to normal controls. RANKL levels were similar in both groups. The groups did not differ with respect to calcium, phosphate, PTH, 25-hydroxyvitamin D, tubular reabsorption of phosphate and cross-linked N-telopeptides of type 1-collagen levels. Abnormalities of mineral metabolism including low serum OPG and 1,25-dihydroxyvitamin D levels occur in patients with type 1 DM with normal renal function and in the absence of microalbuminuria. These abnormalities may promote altered bone metabolism and vascular pathology.
Renal Unit, Lister Hospital, East and North Herts NHS Trust, Stevenage SG1 4AB, UK. dsingh4@nhs.net
Dhruv K
DK
Singh
Peter
P
Winocour
Bev
B
Summerhayes
Adie
A
Viljoen
G
G
Sivakumar
Ken
K
Farrington
D000328:Adult; D015519:Bone Density; D001842:Bone and Bones / Q000378:metabolism; D016022:Case-Control Studies; D048909:Diabetes Complications / Q000097:blood / Q000209:etiology; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000150:complications; D015536:Down-Regulation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008903:Minerals / Q000097:blood; D053244:Osteoprotegerin / Q000097:blood*; D053245:RANK Ligand / Q000097:blood; D014807:Vitamin D / Q000031:analogs & derivatives / Q000097:blood
D008903:Minerals; D053244:Osteoprotegerin; D053245:RANK Ligand; D014807:Vitamin D; C097949:1,25-dihydroxyvitamin D