Cytotoxic acacic acid glycosides from the roots of Albizia coriaria.
Two new oleanane-type saponins, coriariosides A (1) and B (2), along with a known saponin, gummiferaoside C (3), were isolated from the roots of Albizia coriaria. Their structures were established by extensive analysis of 1D and 2D NMR experiments (COSY, ROESY, TOCSY, HSQC, and HMBC) and mass spectrometry. Compounds 1 and 3 when tested for cytotoxicity against two colorectal human cancer cells showed activity against the HCT 116 (IC50 4.2 microM for 1 and 2.7 microM for 3) and HT-29 (IC50 6.7 microM for 1 and 7.9 microM for 3) cell lines.
Noté
Olivier Placide
OP
Laboratoire de Pharmacognosie, UMIB, EA 3660, Faculté de Pharmacie, Université de Bourgogne, 7 Boulevard Jeanne D'Arc, BP 87900, 21079 Dijon Cedex, France.
Mitaine-Offer
Anne-Claire
AC
Miyamoto
Tomofumi
T
Paululat
Thomas
T
Mirjolet
Jean-François
JF
Duchamp
Olivier
O
Pegnyemb
Dieudonné Emmanuel
DE
Lacaille-Dubois
Marie-Aleth
MA
D031289:Albizzia / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002163:Cameroon; D004354:Drug Screening Assays, Antitumor; D045325:HCT116 Cells; D019073:HT29 Cells; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification
D000972:Antineoplastic Agents, Phytogenic; D012503:Saponins; D014315:Triterpenes; C545037:coriarioside A; C545038:coriarioside B; C519243:gummiferaoside C; C413246:oleanane; D009828:Oleanolic Acid