A naturally occurring brominated furanone covalently modifies and inactivates LuxS.
Halogenated furanones, a group of natural products initially isolated from marine red algae, are known to inhibit bacterial biofilm formation, swarming, and quorum sensing. However, their molecular targets and the precise mode of action remain elusive. Herein, we show that a naturally occurring brominated furanone covalently modifies and inactivates LuxS (S-ribosylhomocysteine lyase, EC 4.4.1.21), the enzyme which produces autoinducer-2 (AI-2).
The Barnett Institute and the Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115, USA.
Tianzhu
T
Zang
Bobby W K
BW
Lee
Lisa M
LM
Cannon
Kathryn A
KA
Ritter
Shujia
S
Dai
Dacheng
D
Ren
Thomas K
TK
Wood
Zhaohui Sunny
ZS
Zhou
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D001426:Bacterial Proteins / Q000737:chemistry / Q000378:metabolism*; D001966:Bromine / Q000737:chemistry*; D013437:Carbon-Sulfur Lyases / Q000737:chemistry / Q000378:metabolism*; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D005663:Furans / Q000737:chemistry* / Q000494:pharmacology; D000461:Rhodophyta / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D004791:Enzyme Inhibitors; D005663:Furans; D013437:Carbon-Sulfur Lyases; C117753:LuxS protein, Bacteria; D001966:Bromine