[Antiradiation effects of lactoferrin].
The propose of these examination was studied antiradiation effect of lactoferrin (LF). It was determined, that subcutaneous injection LF (65 or 300 mkg/kg) guinea-pigs irradiated after 1-14 days after of total gamma-irradiation (2.5 Gr) had therapeutically effect attached to the bone marrow form of acute radiation disease (ARD). This effect was explained in increase of survive the animals with 53.8% to 92.8% and stimulation erythropoiesis, judge by number of reticulocytes and increase neutrophiles (12 days ARD) and lymphocytes (12 and 16 days ARD) by comparison with control animals. LF had no effect attached to intestinal form of acute radiation disease by mice. The injection of LF before total irradiation rats of electrons (energy 25 MeV) in doses 255 Gr decreased expression of some symptom of cerebral form of acute radiation disease: prolong time of beginning convulsive period with 5.7 hours to 14.1 hours and duration of life with 7.7 hours to 15.3 hours. LF had antioxidative activity.
Ivanov
A A
AA
Ulanova
A M
AM
Stavrakova
N M
NM
Deshevoĭ
Iu B
IuB
Nasonova
T A
TA
Koterov
A N
AN
Gutsenko
K K
KK
Mal'tsev
V N
VN
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage*; D054022:Cerebrum / Q000187:drug effects / Q000528:radiation effects; D002588:Cesium Radioisotopes / Q000009:adverse effects; D004920:Erythropoiesis / Q000187:drug effects / Q000528:radiation effects; D005720:Gamma Rays / Q000009:adverse effects; D006168:Guinea Pigs; D006801:Humans; D007279:Injections, Subcutaneous; D007422:Intestines / Q000187:drug effects / Q000528:radiation effects; D007781:Lactoferrin / Q000008:administration & dosage* / Q000494:pharmacology; D050356:Lipid Metabolism / Q000187:drug effects; D051379:Mice; D011817:Rabbits; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000008:administration & dosage*; D051381:Rats
D000975:Antioxidants; D002588:Cesium Radioisotopes; D011837:Radiation-Protective Agents; D007781:Lactoferrin