Conjugate addition of indoles to alpha,beta-unsaturated ketones using a Brønsted acid ionic liquid as an efficient catalyst.
The Brønsted acid ionic liquid [PyN(CH(2))(4)SO(3)H][p-CH(3)PhSO(3)] has been reported as an efficient catalyst for the Michael addition reaction of indoles to alpha,beta-unsaturated ketones. Satisfactory results were obtained, with excellent yields and a simple experimental procedure. The catalyst could be recycled and reused up to three times without any noticeable decrease in the catalytic activity.
Yu
Chuan-Ji
CJ
School of Chemistry and Chemical Engineering, Xinjiang University, Key Laboratory of Oil and Gas Fine Chemicals, Ministry of Education, 830046 Urumqi, China. cjxyycj@126.com
Liu
Chen-Jiang
CJ
D000143:Acids / Q000737:chemistry*; D002384:Catalysis; D002599:Chalcone / Q000737:chemistry; D007211:Indoles / Q000737:chemistry*; D052578:Ionic Liquids / Q000737:chemistry*; D007659:Ketones / Q000138:chemical synthesis / Q000737:chemistry*
D000143:Acids; D007211:Indoles; D052578:Ionic Liquids; D007659:Ketones; D002599:Chalcone