New friedelane triterpenoids with antimicrobial activity from the stems of Drypetes paxii.
Two new friedelane-type triterpenes named 12alpha-hydroxyfriedelane-3,15-dione and 3beta-hydroxyfriedelan-25-al, together with six known compounds were isolated from the stems of Drypetes paxii Hutch. (Euphorbiaceae). Their structures were established on the basis of conventional 1 dimensional (1D) NMR methods, 2D shift-correlated NMR experiments and mass spectra. The five friedelane-type triterpene derivatives and one olean-12-ene triterpene saponin were tested for antimicrobial activity against some gram-positive and gram-negative bacteria, and they appeared to be modestly active.
Laboratoire de Synthèse et de Substances Naturelles, Département de Chimie Organique de l'Université de Yaoundé-1, Faculté des Sciences, Cameroon.
David Dako
DD
Chiozem
Hanh
H
Trinh-Van-Dufat
Jean Duplex
JD
Wansi
Céline
C
Mbazoa Djama
Véronique Simone
VS
Fannang
Elisabeth
E
Seguin
François
F
Tillequin
Jean
J
Wandji
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D052978:Disk Diffusion Antimicrobial Tests; D019665:Euphorbiaceae / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D018547:Plant Stems / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
C545756:12 alpha-hydroxyfriedelane-3,15-dione; C545757:3 beta-hydroxyfriedelan-25-al; D000900:Anti-Bacterial Agents; D014315:Triterpenes; C421805:friedelane