Synthesis of novel 3,5-dichloro-2-arylpyridines by palladium acetate-catalyzed ligand-free Suzuki reactions in aqueous media.
A highly efficient palladium acetate-catalyzed ligand-free Suzuki reaction of 2,3,5-trichloropyridine with arylboronic acids in aqueous phase was developed. High yields of 3,5-dichloro-2-arylpyridines, a simple Pd source, absence of ligands, and environmentally benign as well as mild reaction conditions are important features of this method.
College of Pharmaceutial and Chemical Engineering, Taizhou University, Linhai 317000, China. hhn12192000@yahoo.com.cn
Huanan
H
Hu
Changhua
C
Ge
Anjiang
A
Zhang
Lisheng
L
Ding
D000085:Acetates / Q000737:chemistry*; D001897:Boronic Acids / Q000737:chemistry; D002384:Catalysis; D008024:Ligands; D008956:Models, Chemical; D009942:Organometallic Compounds / Q000737:chemistry*; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry; D012996:Solutions; D012997:Solvents / Q000737:chemistry; D013997:Time Factors; D014867:Water / Q000737:chemistry*
D000085:Acetates; D001897:Boronic Acids; D008024:Ligands; D009942:Organometallic Compounds; D011725:Pyridines; D012996:Solutions; D012997:Solvents; D014867:Water; C516071:palladium(II) acetate