[Cirrhotic cardiomyopathy].
Cirrhotic cardiomyopathy is defined as structural and functional cardiac abnormalities occurring in patients with cirrhosis, in the absence of any other associated cardiac disease. Its main clinical features include systolic and diastolic dysfunctions, and electrophysiological changes. Cirrhotic cardiomyopathy is generally clinically latent and is unmasked when the patient is exposed to major physiological stress or after some procedures, thus leading to an overt cardiac failure. Pathogenic mechanisms include impaired beta-adrenergic receptor signal transduction and increased activity of cardio-depressor pathways. A certain reversibility has been shown in the medium-long term after a liver transplantation. This article proposes to review the physiopathological mechanisms underlying these abnormalities, their clinical impacts, and the management options.
Service de gastroentérologie et hepatologie, HUG, 1211 Genève 14. mariam.seirafi@hcuge.ch
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Seirafi
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Spahr
D009202:Cardiomyopathies / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications* / Q000503:physiopathology