Reassembling biological machinery in vitro.
Inspired by the specialized glycolytic system of flagella of mammalian sperm, Mukai et al. (2009) describe the controlled immobilization of two enzymes constituting the first steps in the glycolytic pathway. Extension of this work may provide "power converters" for bionanodevices, which transduce chemical energy from glucose to ATP.
Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA. hh2374@columbia.edu
Henry
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Hess
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D004800:Enzymes, Immobilized / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism; D005956:Glucose-6-Phosphate Isomerase / Q000737:chemistry / Q000378:metabolism*; D006593:Hexokinase / Q000737:chemistry / Q000378:metabolism*; D051379:Mice; D009532:Nickel / Q000737:chemistry; D009571:Nitrilotriacetic Acid / Q000737:chemistry
D004800:Enzymes, Immobilized; D009532:Nickel; D000255:Adenosine Triphosphate; D006593:Hexokinase; D005956:Glucose-6-Phosphate Isomerase; D005947:Glucose; D009571:Nitrilotriacetic Acid