Effects of weight loss on lipid transfer proteins in morbidly obese women.
Obesity is associated with lipid abnormalities leading to an increased morbidity and mortality from atherosclerotic disease. Lipid transfer proteins such as Cholesteryl Ester Transfer Protein (CETP) and Phospholipid Transfer Protein (PLTP), and lipases such as lipoprotein lipase (LPL) and hepatic lipase (HL) are involved in the pathogenesis of the obesity associated proatherogenic dyslipidemia. Nineteen severely obese female subjects undergoing laparosopic gastric banding participated in this prospective study. Subjects were examined with respect to body composition, lipid profile, CETP, PLTP, LPL and HL before and 1 year after surgical treatment. Mean weight loss was 22.2 kg, mainly due to losses in the fat depots. Triglycerides decreased and HDL(2)-C increased significantly. In respect to transfer proteins mean CETP mass decreased from 1.82 to 1.71 microg mL(-1) (P = 0.043) and mean PLTP activity was reduced from 7.15 to 6.12 micromol mL(-1) h(-1) (P = 0.002), in parallel. In addition, both mean LPL activity and mean HL activity tended to decrease from 297 to 248 nmol mL(-1) h(-1) for LPL (P = 0.139) and from 371 to 319 nmol mL(-1) h(-1) for HL (P = 0.170), respectively. We conclude that weight loss induced by bariatric surgery is associated with the amelioration of the obesity-associated dyslipidemic state. This improvement may be attributable to decreased mass and action of the adipocyte tissue derived lipid transfer proteins CETP and PLTP.
Department of Internal Medicine I, Medical University Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.
Markus W
MW
Laimer
Julia
J
Engl
Alexander
A
Tschoner
Susanne
S
Kaser
Andreas
A
Ritsch
Tobias
T
Tatarczyk
Markus
M
Rauchenzauner
Helmut
H
Weiss
Franz
F
Aigner
Josef R
JR
Patsch
Christoph F
CF
Ebenbichler
D000328:Adult; D015992:Body Mass Index; D002352:Carrier Proteins / Q000097:blood*; D053480:Cholesterol Ester Transfer Proteins / Q000378:metabolism; D005260:Female; D006801:Humans; D008049:Lipase / Q000378:metabolism; D008071:Lipoprotein Lipase / Q000378:metabolism; D009765:Obesity / Q000097:blood* / Q000601:surgery; D049294:Phospholipid Transfer Proteins / Q000378:metabolism; D011446:Prospective Studies; D015431:Weight Loss / Q000502:physiology*
C506642:CETP protein, human; D002352:Carrier Proteins; D053480:Cholesterol Ester Transfer Proteins; C504173:LIPC protein, human; C493430:PLTP protein, human; D049294:Phospholipid Transfer Proteins; C030363:lipid transfer protein; D008049:Lipase; D008071:Lipoprotein Lipase