A deformable model for tracking tumors across consecutive imaging studies.
OBJECTIVE
A deformable registration technique was developed and evaluated to track and quantify tumor response to radiofrequency ablation for patients with liver malignancies.


METHODS
The method uses the combined power of global and local alignment of pre- and post-treatment computed tomography image data sets. The strategy of the algorithm is to infer volumetric deformation based upon surface displacements using a linearly elastic finite element model (FEM). Using this framework, the major challenge for tracking tumor location is not the tissue mechanical properties for FEM modeling but rather the evaluation of boundary conditions. Three different methods were systematically investigated to automatically determine the boundary conditions defined by the correspondences on liver surfaces.


RESULTS
Using both 2D synthetic phantoms and imaged 3D beef liver data we performed gold standard registration while measuring the accuracy of non-rigid deformation. The fact that the algorithms could support mean displacement error of tumor deformation up to 2 mm indicates that this technique may serve as a useful tool for surgical interventions. The method was further demonstrated and evaluated using consecutive imaging studies for three liver cancer patients.


CONCLUSIONS
The FEM-based surface registration technique provides accurate tracking and monitoring of tumor and surrounding tissue during the course of treatment and follow-up.
Center for Biomedical Imaging and Informatics, The Cancer Institute of New Jersey, New Brunswick, NJ, USA. gnicules@eden.rutgers.edu
Gabriela
G
Niculescu
John L
JL
Nosher
M D Benjamin
MD
Schneider
David J
DJ
Foran
D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging* / Q000601:surgery; D017115:Catheter Ablation / Q000379:methods; D003198:Computer Simulation; D003937:Diagnosis, Differential; D020342:Finite Element Analysis; D005500:Follow-Up Studies; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D014057:Tomography, X-Ray Computed / Q000379:methods*