mir-210: a sensor for hypoxic stress during tumorigenesis.
In this issue of Molecular Cell, Huang et al. (2009) demonstrate that hypoxia-inducible mir-210 acts as a rheostat for cellular adaptation and survival by inhibiting tumor initiation.
Mathew
Lijoy K
LK
Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.
Simon
M Celeste
MC
D000818:Animals; D015687:Cell Hypoxia; D049109:Cell Proliferation; D002471:Cell Transformation, Neoplastic / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D015972:Gene Expression Regulation, Neoplastic; D020868:Gene Silencing; D015316:Genetic Therapy; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000235:genetics / Q000378:metabolism; D035683:MicroRNAs / Q000378:metabolism*; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D011485:Protein Binding; D051500:Receptor, Fibroblast Growth Factor, Type 5 / Q000235:genetics / Q000378:metabolism; D013312:Stress, Physiological / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic; D015854:Up-Regulation; D000099261:Homeobox A1 Protein
D018398:Homeodomain Proteins; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D035683:MicroRNAs; D051500:Receptor, Fibroblast Growth Factor, Type 5; D014157:Transcription Factors; D000099261:Homeobox A1 Protein; C417531:FGFRL1 protein, human; C497442:HIF1A protein, human; C543800:MIRN210 microRNA, human; C097899:homeobox protein HOXA9