Myopathy secondary to intravascular large B-cell lymphoma.
We report a case of a 78-year-old woman presenting with progressive proximal muscle weakness mainly to lower limbs and myopathic EMG associated with intravascular large B-cell lymphoma. Muscle biopsy showed myopathic changes, intravascular large B-cell lymphoma but no inflammation or fibre necrosis; the patient's serum cross-reacted with an unidentified nuclear antigen of approximately 45 kDa present in muscle and lymphoma cells. Our case illustrates a myopathy associated with intravascular large B-cell lymphoma probably mediated by antibodies cross-reacting with a nuclear protein expressed by neoplastic cells and normal muscle. The nature of this nuclear antigen remains unidentified.
Division of Clinical Neurosciences, Imperial College London, UK.
C
C
Marini-Bettolo
R
R
Lane
P
P
Charles
K
K
Naresh
R
R
Nicholas
P
P
Singh
A
A
Cohen
P
P
Mackie
F
F
Roncaroli
D000368:Aged; D001774:Blood Chemical Analysis; D015153:Blotting, Western; D004576:Electromyography; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D016403:Lymphoma, Large B-Cell, Diffuse / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D018482:Muscle, Skeletal / Q000473:pathology / Q000503:physiopathology; D009135:Muscular Diseases / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D009687:Nuclear Proteins / Q000378:metabolism
D009687:Nuclear Proteins