Preventive oncology in the postmenopausal woman.
Breast cancer and endometrial cancer are the most common gynecologic malignancies of the postmenopausal period. As preventive medicine becomes the focus of interest, preventive oncology with special regard to these diseases will undoubtedly become a substantial part of the practicing oncologist's field of duties. The aim of this review is to summarize recommendations dealing with the risk assessment and prevention of breast and endometrial cancer. Obesity, the level of exercise and dietary factors are associated with breast cancer. The selective estrogen receptor modulators tamoxifen and raloxifen have both been shown to decrease the risk to the same extent. Patients at particularly high risk are being detected through the use of the Gail model, a well-known statistical model of risk. Other factors, such as breast density, the serum level of endogenous estrogen and the presence of single nucleotide polymorphisms, have to be taken into consideration.
Huber
Johannes C
JC
University Hospital Vienna, Department for Gynaecological Endocrinology and Reproductive Medicine, A-1090 Vienna, Währinger Gürtel 18-20, Austria. johannes.huber@meduniwien.ac.at.
Ott
Johannes
J
Tempfer
Clemens B
CB