Event-related potentials in clinical research: guidelines for eliciting, recording, and quantifying mismatch negativity, P300, and N400.
This paper describes recommended methods for the use of event-related brain potentials (ERPs) in clinical research and reviews applications to a variety of psychiatric and neurological disorders. Techniques are presented for eliciting, recording, and quantifying three major cognitive components with confirmed clinical utility: mismatch negativity (MMN), P300, and N400. Also highlighted are applications of each of the components as methods of investigating central nervous system pathology. The guidelines are intended to assist investigators who use ERPs in clinical research, in an effort to provide clear and concise recommendations and thereby to standardize methodology and facilitate comparability of data across laboratories.
Duncan
Connie C
CC
Clinical Psychophysiology and Psychopharmacology Laboratory, Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Electronic address: cduncan@usuhs.mil.
Barry
Robert J
RJ
School of Psychology and Brain & Behaviour Research Institute, University of Wollongong, Wollongong, NSW, Australia.
Connolly
John F
JF
Department of Linguistics and Languages, McMaster University, Hamilton, Ont., Canada.
Fischer
Catherine
C
Hospices Civils de Lyon, Neurological Hospital and INSERM U821, Lyon, France.
Michie
Patricia T
PT
School of Psychology, The University of Newcastle, Callaghan, NSW, Australia.
Näätänen
Risto
R
Department of Psychology, University of Tartu, Tartu, Estonia; Center of Functionally Integrative Neuroscience (CFIN), University of Aarhus, Aarhus, Denmark; Cognitive Brain Research Unit, Department of Psychology, University of Helsinki, Helsinki, Finland.
Polich
John
J
Cognitive Electrophysiology Laboratory, Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA, USA.
Reinvang
Ivar
I
Department of Psychology, University of Oslo, Oslo, Norway.
Van Petten
Cyma
C
Department of Psychology, Binghamton University, Binghamton, New York, USA.
D000818:Animals; D001930:Brain Injuries / Q000175:diagnosis / Q000503:physiopathology; D018913:Event-Related Potentials, P300 / Q000502:physiology*; D006801:Humans; D001523:Mental Disorders / Q000175:diagnosis / Q000503:physiopathology; D017410:Practice Guidelines as Topic / Q000592:standards*