Ryanodine receptor dysfunction in arrhythmia and sudden cardiac death.
Mutations in ryanodine receptor calcium ion-release channels (RyR2) have emerged as important causative players in exercise/stress-induced ventricular arrhythmia leading to sudden cardiac death (SCD). Thus, RyR2 represents an attractive therapeutic target, and a detailed understanding of the mechanistic basis of RyR2 dysfunction at the molecular, cellular and organ level is essential for the development of novel, more effective therapeutic approaches to prevent arrhythmia and SCD. Such advances will translate into a tremendous improvement in the survival and quality of life of SCD-susceptible individuals. In this review, the authors consider how recent knowledge gained from mutation identification, phenotypic manifestation and functional evaluation of RyR2 mutants, are being used to develop novel therapeutic strategies in RyR2-dependent arrhythmia.
George
Christopher H
CH
Cardiff University School of Medicine, Department of Cardiology, Wales Heart Research Institute, Heath Park, Cardiff, CF14 4XN, UK. georgech@cf.ac.uk
Thomas
N Lowri
NL
Lai
F Anthony
FA