Methicillin-resistant Staphylococcus aureus infection after lung transplantation: 5-year review of clinical and molecular epidemiology.
BACKGROUND
Data on the epidemiology of MRSA infection in lung transplantation is limited.


METHODS
We performed a 5-year retrospective study to assess the incidence and microbiologic and clinical characteristics of methicillin-resistant Staphylococcus aureus (MRSA) infection in a cohort of 163 lung transplant recipients.


RESULTS
Seventeen patients with MRSA colonization and/or infection were identified, for a calculated incidence rate of 76.1 cases per 1,000 transplanted-years. Pulsed-field gel electrophoresis identified 3 different distinct MRSA profiles, all of them consistent with hospital-associated MRSA infection.


CONCLUSIONS
Despite negative polymerase chain reaction (PCR) for the virulence factor Panton-Valentine leukocidin, MRSA infections resulted in significant disease and morbidity.
Transplant Infectious Diseases, University of Alberta, Edmonton, Alberta, Canada.
Oriol
O
Manuel
Dale
D
Lien
Justin
J
Weinkauf
Atul
A
Humar
Isabel
I
Cobos
Deepali
D
Kumar
D000293:Adolescent; D000328:Adult; D016521:Electrophoresis, Gel, Pulsed-Field; D005500:Follow-Up Studies; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D015994:Incidence; D016040:Lung Transplantation / Q000009:adverse effects* / Q000276:immunology; D055624:Methicillin-Resistant Staphylococcus aureus / Q000302:isolation & purification; D012189:Retrospective Studies; D013203:Staphylococcal Infections / Q000453:epidemiology*; D013997:Time Factors; D055815:Young Adult
D007166:Immunosuppressive Agents