Self-assembled multifunctional Fe/MgO nanospheres for magnetic resonance imaging and hyperthermia.
A one-step process for the production of nanoparticles presenting advanced magnetic properties can be achieved using vapor condensation. In this article, we report on the fabrication of Fe particles covered by a uniform MgO epitaxial shell. MgO has a lower surface energy than Fe, which results in a core-shell crystal formation. The particles satisfy a few of technical requirements for the practical use in real clinics, such as a high biocompatibility in living cells in-vitro, an injection through blood vessels without any clothing problems in murine model, a high absorption rate for magnetic hyperthermia at small particle concentration, and the potential to be used as contrast agent in the field of diagnostic magnetic imaging. They are also able to be used in drug delivery and magnetic-activated cell sorting.


BACKGROUND
In this paper, the authors report on the synthesis of Fe particles covered by a uniform MgO epitaxial shell resulting in a core-shell crystal formation. The particles are proven to be useful as contrast agents for magnetic resonance imaging and have the potential to be useful as heating mediators for cancer therapy through hyperthermia. They also might be used in drug delivery and magnetic-activated cell sorting.
Martinez-Boubeta
Carlos
C
ICMAB-CSIC, Campus UAB, Bellaterra, Spain. cboubeta@el.ub.es
Balcells
Lluis
L
Cristòfol
Rosa
R
Sanfeliu
Coral
C
Rodríguez
Elisenda
E
Weissleder
Ralph
R
Lope-Piedrafita
Silvia
S
Simeonidis
Konstantinos
K
Angelakeris
Makis
M
Sandiumenge
Felip
F
Calleja
Alberto
A
Casas
Lluis
L
Monty
Claude
C
Martínez
Benjamin
B
D003287:Contrast Media / Q000737:chemistry*; D003460:Crystallization / Q000379:methods; D004339:Drug Compounding / Q000379:methods; D006979:Hyperthermia, Induced / Q000379:methods*; D007501:Iron / Q000737:chemistry*; D008277:Magnesium Oxide / Q000737:chemistry*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D054118:Nanospheres / Q000737:chemistry*
D003287:Contrast Media; D008277:Magnesium Oxide; D007501:Iron