Early-stage BRCA2-linked breast cancer diagnosed in the first trimester of pregnancy associated with a hypercoagulable state.
This patient was found to have a BRCA2 gene mutation. She underwent lumpectomy and axillary lymph node dissection without any evidence of lymph node metastasis. Systemic chemotherapy with doxorubicin and cyclophosphamide for four cycles was administered beginning in the second trimester. She was treated with prophylactic LMWH until delivery and then for 6 weeks postpartum. She delivered a healthy baby boy and, after a period of breast-feeding, underwent bilateral mastectomy with immediate reconstruction. She remains well and is expecting her second child. Prophylactic oophorectomy is planned after completion of this pregnancy.
Diamond
Jennifer R
JR
Division of Medical Oncology, University of Colorado Health Sciences Center, Denver, Colorado, USA.
Finlayson
Christina A
CA
Thienelt
Christiane
C
Kabos
Peter
P
Hardesty
Laura
L
Barbour
Linda
L
Klein
Catherine E
CE
Rabinovitch
Rachel
R
Elias
Anthony
A
Borges
Virginia F
VF
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D051017:Apoptosis Regulatory Proteins; D024682:BRCA2 Protein / Q000235:genetics*; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008197:Lymph Node Excision; D008297:Male; D015412:Mastectomy, Segmental; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics; D011261:Pregnancy Trimester, First; D011262:Pregnancy Trimester, Second; D011379:Prognosis; D019851:Thrombophilia / Q000150:complications / Q000175:diagnosis*
D051017:Apoptosis Regulatory Proteins; C118024:BLID protein, human; D024682:BRCA2 Protein; C551750:BRCA2 protein, human; D004317:Doxorubicin; D003520:Cyclophosphamide