[Changes of peripheral blood chromosomal centromere aberration in patients with cytomegalovirus infection after anti-viral treatment].
OBJECTIVE
To study the changes of peripheral blood chromosomal centromere aberration in patents with cytomegalovirus (CMV) infection after anti-viral treatment.


METHODS
Sixty-two patients with early spontaneous abortion and CMV infection analyzed for their peripheral blood chromosomal centromere using simultaneous silver staining before and after anti-viral treatment.


RESULTS
The patients with CMV infection had high rate of centromere aberration, which was decreased significantly after anti-viral treatment (P<0.0001).


CONCLUSIONS
CMV infection is a risk factor for peripheral blood chromosomal centrimere aberration. Anti-viral treatment can decrease the rate of centrimere aberration aberration. Detection of peripheral blood chromosomal centrimere aberration allows the assessment of the severity of infection and the condition after treatment.
Clinical Laboratory, Henan People's Hospital, Zhengzhou, China.
Lan
L
Gao
Yan-hui
YH
Liu
Li-fen
LF
Li
Ya-min
YM
Wu
Ming-bo
MB
Wang
Jing
J
Shi
Bing
B
Yuan
Juan
J
Song
Yong-ming
YM
He
Dai-kui
DK
Wei
D000022:Abortion, Spontaneous / Q000097:blood / Q000235:genetics; D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D002503:Centromere / Q000235:genetics*; D002869:Chromosome Aberrations; D003586:Cytomegalovirus Infections / Q000097:blood / Q000188:drug therapy / Q000235:genetics*; D005260:Female; D006801:Humans; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000097:blood / Q000188:drug therapy / Q000235:genetics*; D055815:Young Adult
D000998:Antiviral Agents