Conjugate addition of indoles to alpha,beta-unsaturated ketones using a Brønsted acid ionic liquid as an efficient catalyst.
The Brønsted acid ionic liquid [PyN(CH(2))(4)SO(3)H][p-CH(3)PhSO(3)] has been reported as an efficient catalyst for the Michael addition reaction of indoles to alpha,beta-unsaturated ketones. Satisfactory results were obtained, with excellent yields and a simple experimental procedure. The catalyst could be recycled and reused up to three times without any noticeable decrease in the catalytic activity.
School of Chemistry and Chemical Engineering, Xinjiang University, Key Laboratory of Oil and Gas Fine Chemicals, Ministry of Education, 830046 Urumqi, China. cjxyycj@126.com
Chuan-Ji
CJ
Yu
Chen-Jiang
CJ
Liu
D000143:Acids / Q000737:chemistry*; D002384:Catalysis; D002599:Chalcone / Q000737:chemistry; D007211:Indoles / Q000737:chemistry*; D052578:Ionic Liquids / Q000737:chemistry*; D007659:Ketones / Q000138:chemical synthesis / Q000737:chemistry*
D000143:Acids; D007211:Indoles; D052578:Ionic Liquids; D007659:Ketones; D002599:Chalcone