Prediction of pre-eclampsia in early pregnancy.
Pre-eclampsia is a multisystem disorder of pregnancy, usually characterized by the appearance of high blood pressure and the excretion of protein in the urine of a previously healthy woman. Symptoms and signs vary in intensity from woman to woman; from a borderline rise in blood pressure, to convulsions (eclampsia), stroke and death. The disease remits following removal of the placenta and so the mainstay of current treatment is timely delivery. A pathophysiological framework of the disease has been established, beginning with failures in placental development, inducing oxidative stress and release of compounds that lead to endothelial activation, vasoconstriction and glomerular endotheliosis. A combination of epidemiological, biophysical and biochemical tests now allow most patients at-risk to be identified by midpregnancy, whilst minimizing false-positive prediction. It is hoped that earlier classification of patients at-risk of the disease, on the basis of pathophysiological changes, will enable specific therapies to be developed targeting these changes.
The Chinese University of Hong Kong, Department of Obstetrics and Gynaecology, Faculty of Medicine, Prince of Wales Hospital, Shatin, New Territories, Hong Kong. msrogers@cuhk.edu.hk.
Mike S
MS
Rogers