Hyperbaric oxygen therapy as an anti-infective agent.
Hyperbaric oxygen therapy (HBOT) involves inhalation of 100% oxygen at supra-atmospheric ambient pressure. HBOT is used as either a primary or adjunctive treatment in the management of infections such as gas gangrene, necrotizing fasciitis, diabetic foot infections, refractory osteomyelitis, neurosurgical infections and fungal infections. HBOT acts as a bactericidal/bacteriostatic agent against anerobic bacteria by increasing the formation of free oxygen radicals. HBOT restores the bacterial-killing capacity of leukocytes in hypoxic wounds by increasing tissue oxygen tensions. In addition, HBOT acts synergistically with a number of antibiotics. This article reviews the anti-infective effects of HBOT and the use of HBOT in the treatment of certain infectious diseases.
Cimşit
Maide
M
Department of Underwater and Hyperbaric Medicine, Istanbul University, Medical Faculty, Istanbul, Turkey. mcimsit@istanbul.edu.tr
Uzun
Günalp
G
Yildiz
Senol
S
D000890:Anti-Infective Agents / Q000627:therapeutic use*; D003141:Communicable Diseases / Q000628:therapy*; D017719:Diabetic Foot / Q000150:complications / Q000628:therapy; D019115:Fasciitis, Necrotizing / Q000628:therapy; D005738:Gas Gangrene / Q000628:therapy; D006931:Hyperbaric Oxygenation / Q000295:instrumentation / Q000379:methods / Q000706:statistics & numerical data; D009181:Mycoses / Q000628:therapy; D010019:Osteomyelitis / Q000628:therapy; D013530:Surgical Wound Infection / Q000628:therapy; D016896:Treatment Outcome
D000890:Anti-Infective Agents