Interleukin 10 family gene polymorphisms are not associated with major depressive disorder and panic disorder phenotypes.
Genetic regulation of immune system and inflammatory response may be related to the pathogenesis and manifestations of mood and anxiety disorders. In the present study we examined a range of single-nucleotide polymorphisms (SNP) in chromosomal region 1q32, the locus of interleukin 10 (IL10) gene, in patients with major depressive disorder (n=312) and panic disorder (n=210), and matched healthy controls (n=356). We found no significant associations of the SNPs in IL10 family genes with either diagnostic group. Haplotype analysis revealed seven haplotype blocks, but their frequencies did not differ between patients and controls. Significant associations were detected for SNP rs1539243 in IKBKE (inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon) gene showing different allelic and genotypic distributions in the total as well as in separate diagnostic groups as compared to controls. IKBKE emerged as a candidate for further studies of genetic factors associated with panic disorder and major depressive disorder.
Koido
Kati
K
Department of Physiology, University of Tartu, Tartu, Estonia. kati.koido@ut.ee <kati.koido@ut.ee>
Eller
Triin
T
Kingo
Külli
K
Kõks
Sulev
S
Traks
Tanel
T
Shlik
Jakov
J
Vasar
Veiko
V
Vasar
Eero
E
Maron
Eduard
E
D003865:Major Depressive Disorder / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study / Q000379:methods; D005838:Genotype; D006801:Humans; D051550:I-kappa B Kinase / Q000235:genetics; D016753:Interleukin-10 / Q000235:genetics*; D008297:Male; D016584:Panic Disorder / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
D016753:Interleukin-10; D051550:I-kappa B Kinase; C496565:IKBKE protein, human