Improvement in quality-of-life questionnaire measures in obese adolescent females with polycystic ovary syndrome treated with lifestyle changes and oral contraceptives, with or without metformin.
We studied the effect of metformin or placebo in a lifestyle modification program combined with oral contraceptives (OC) on quality-of-life parameters measured by the polycystic ovary syndrome (PCOS) questionnaire in obese adolescent women with validated PCOS. The quality-of-life indicators were measured at baseline and conclusion for five domains on the PCOS questionnaire, with equal improvement in scores in both placebo and metformin groups, suggesting that the addition of metformin does not add improvement to quality-of-life measures above those observed with lifestyle modification and OC treatment.
Department of Obstetrics & Gynecology, University of Rochester School of Medicine and Dentistry, Rochester, NY, 601 Elmwood Avenue, Box 668, Rochester, NY 14642, USA. Miranda_harris-glocker@urmc.rochester.edu
Miranda
M
Harris-Glocker
Kristin
K
Davidson
Lynda
L
Kochman
David
D
Guzick
Kathleen
K
Hoeger
D000293:Adolescent; D003131:Combined Modality Therapy; D003276:Contraceptives, Oral / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage*; D008019:Life Style; D008687:Metformin / Q000008:administration & dosage*; D009765:Obesity / Q000188:drug therapy* / Q000523:psychology; D010353:Patient Education as Topic; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy* / Q000523:psychology; D011446:Prospective Studies; D011788:Quality of Life; D011795:Surveys and Questionnaires
D003276:Contraceptives, Oral; D007004:Hypoglycemic Agents; D008687:Metformin