Emergence of multidrug-resistant Salmonella enterica serovar Typhi with reduced susceptibility to fluoroquinolones in Cambodia.
From December 2006 to April 2009, we conducted an etiology study among Cambodian patients presenting with acute fever of unknown origin. Salmonella enterica serovar Typhi was detected in 0.9% (41/4985) blood cultures. Antimicrobial susceptibility testing showed decreased susceptibility to ampicillin (56% resistant; MIC(90), >256 microg/mL), chloramphenicol (56% resistant; MIC(90), >256 microg/mL), trimethoprim/sulfamethoxazole (56% resistant; MIC(90), >256 microg/mL), nalidixic acid (81% resistant; MIC(90), not defined), ciprofloxacin (0% resistant; MIC(90), 0.5 microg/mL), and ceftriaxone (0% resistant; MIC(90), 0.094 microg/mL). Multidrug resistance, defined as antimicrobial resistance to ampicillin, chloramphenicol, and trimethoprim/sulfamethoxazole, was found in 56% of the isolates, and 80% had reduced susceptibility to ciprofloxacin (defined as MIC > or =0.12 microg/mL).
Kasper
Matthew R
MR
US Naval Medical Research Unit, Jakarta, Indonesia. kasper@namrutwo.org
Sokhal
Buth
B
Blair
Patrick J
PJ
Wierzba
Thomas F
TF
Putnam
Shannon D
SD
D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002160:Cambodia; D002648:Child; D024901:Drug Resistance, Multiple, Bacterial; D005260:Female; D024841:Fluoroquinolones / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D012485:Salmonella typhi / Q000187:drug effects* / Q000302:isolation & purification; D014435:Typhoid Fever / Q000382:microbiology*
D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones