Asymmetric meso-aziridine ring-opening reactions using a chiral zirconium catalyst.
A chiral zirconium catalyst prepared from Zr(O(t)Bu)4 and a chiral tridentate BINOL was found to be effective for asymmetric meso-aziridine ring-opening reactions with aniline derivatives. The N-benzhydryl group on the product obtained was easily cleaved to give the corresponding amine in high yield under reductive conditions.
Seki
Kazutaka
K
Department of Chemistry, School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Yu
Rongmin
R
Yamazaki
Yumi
Y
Yamashita
Yasuhiro
Y
Kobayashi
Shū
S
D000814:Aniline Compounds / Q000737:chemistry; D001388:Aziridines / Q000737:chemistry*; D002384:Catalysis; D013237:Stereoisomerism; D015040:Zirconium / Q000737:chemistry*
D000814:Aniline Compounds; D001388:Aziridines; C033132:aziridine; D015040:Zirconium; C023650:aniline