Three-dimensional fluorescence optical tomography in small-animal imaging using simultaneous positron-emission-tomography priors.
We propose three-dimensional fluorescence optical tomography imaging for small animals guided by simultaneous priors from positron emission tomography (PET). Using a sparsity regularization, the target prior from PET images was incorporated into the reconstruction algorithm for optical imaging. The method and algorithms are validated with numerical simulations and a phantom experiment performed on a combined optical-PET scanner based on a conical mirror geometry.
Li
Changqing
C
Department of Biomedical Engineering, University of California, Davis, Davis, California 95616, USA. cqli@ucdavis.edu
Wang
Guobao
G
Qi
Jinyi
J
Cherry
Simon R
SR
D000465:Algorithms; D000818:Animals; D003198:Computer Simulation; D004867:Equipment Design; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods; D051379:Mice; D008962:Models, Theoretical; D016011:Normal Distribution; D019047:Phantoms, Imaging; D049268:Positron-Emission Tomography / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000379:methods*