Destruction of RhoA CULtivates actin.
Cullin 3, the core subunit of the CRL3 ubiquitin ligase family, is essential for development, but its substrates remain poorly defined. Here, Chen et al. (2009) report that CRL3(BACURD) targets the RhoA GTPase for degradation, thereby maintaining actin cytoskeleton integrity.
Signal Transduction Program, Burnham Institute for Medical Research, La Jolla, CA 92037, USA. shdwu@burnham.org
Shuangding
S
Wu
Dieter A
DA
Wolf
D000199:Actins / Q000378:metabolism*; D000818:Animals; D002465:Cell Movement; D048430:Cell Shape; D017124:Conserved Sequence; D044842:Cullin Proteins / Q000235:genetics / Q000378:metabolism*; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism*; D019143:Evolution, Molecular; D054262:Gastrulation; D006801:Humans; D046912:Multiprotein Complexes; D011499:Protein Processing, Post-Translational; D011994:Recombinant Proteins / Q000378:metabolism; D022502:Stress Fibers / Q000378:metabolism*; D013379:Substrate Specificity; D054875:Ubiquitination; D014981:Xenopus / Q000196:embryology; D029867:Xenopus Proteins / Q000235:genetics / Q000378:metabolism; D020742:rhoA GTP-Binding Protein / Q000378:metabolism*
D000199:Actins; C503645:CUL3 protein, human; C503647:Cul3 protein, Drosophila; D044842:Cullin Proteins; D029721:Drosophila Proteins; D046912:Multiprotein Complexes; D011994:Recombinant Proteins; D029867:Xenopus Proteins; D020742:rhoA GTP-Binding Protein