Air-stable secondary phosphine oxide as preligand for palladium-catalyzed intramolecular alpha-arylations with chloroarenes.
A palladium catalyst derived from air-stable secondary phosphine oxide (1-Ad)(2)P(O)H enabled efficient intramolecular alpha-arylations of amides with aryl chlorides, which allowed for the synthesis of diversely substituted (aza)oxindoles.
Institut fuer Organische und Biomolekulare Chemie, Georg-August-Universitaet, Tammannstrasse 2, 37077 Goettingen, Germany. lutz.ackermann@chemie.uni-goettingen.de
Lutz
L
Ackermann
Rubén
R
Vicente
Nora
N
Hofmann
D000577:Amides / Q000737:chemistry; D001372:Aza Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D006843:Hydrocarbons, Chlorinated / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D008024:Ligands; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry; D010087:Oxides / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D010720:Phosphines / Q000737:chemistry*; D013237:Stereoisomerism
D000577:Amides; D001372:Aza Compounds; D006843:Hydrocarbons, Chlorinated; D007211:Indoles; D008024:Ligands; D009942:Organometallic Compounds; D010087:Oxides; D010720:Phosphines; D010165:Palladium