Etiopathogenesis of cardiomyopathies: a review.
An article reviews etiopathogenesis of cardiomyopathy. Regardless of the fact that many early days' fundamental investigations are devoted to cardiomyopathy problem, still there is no common consideration concerning the etiology, pathogenesis, morphogenesis, classification and therapy of cardiomyopathy as well. Problem concerning the etiology of cardiomyopathy appear of particular interest. Great number of authors put an emphasis on the role of coxsackie B viruses' group encompasses enteroviruses with well defined cardiotropic features. Smoking is believed to play significant role in the evolution of cardiomyopathy, having drastic effect on the oxidative and energetic processes of the cells. Consequently, the phrase "cardiomyopathy during smoking" seems quite relevant. On behalf of World Public Health Services recommendation the term cardiomyopathy encloses patients with myocarditis of unknown origin with well defined characteristic features - megalocardia and cardiac decompensation. However, heart valve, coronary and lung vessels injuries are excluded. Note worthily, concept "secondary cardiomyopathy" is not well interpreted, especially as in this case etiology is well understood. Due to the complexity of differential diagnostics for congestive cardiomyopathy and myocardial ischemia in present day literature the term "ischemic cardiomyopathy" is widely applicable. Frequently, patients with congestive cardiomyopathy and myocardial ischemia reveal identical clinical-angiocardiographic set of symptoms determined by generalized injury of cardiac muscle. Taking into account all the above mentioned data it is evident that regarding etio pathogenesis and morphogenesis cardiomyopathy is not completely explored pathology and needs further investigation. The goal here is revelation of factors affecting cardiac contractile function. Besides, elaboration of new, effective pharmaceutical means seems of great importance.
Tbilisi Scientific Practical Center of Clinical Pathology.
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Kirvalidze
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Jorbenadze
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Khetsuriani
D000818:Animals; D009202:Cardiomyopathies / Q000209:etiology* / Q000235:genetics / Q000276:immunology / Q000821:virology; D006801:Humans