Directed intermittent search for a hidden target on a dendritic tree.
Motivated by experimental observations of active (motor-driven) intracellular transport in neuronal dendrites, we analyze a stochastic model of directed intermittent search on a tree network. A particle injected from the cell body or soma into the primary branch of the dendritic tree randomly switches between a stationary search phase and a mobile nonsearch phase that is biased in the forward direction. A (synaptic) target is presented somewhere within the tree, which the particle can locate if it is within a certain range and in the searching phase. We approximate the moment generating function using Green's function methods. The moment generating function is then used to compute the hitting probability and conditional mean first passage time to the target. We show that in contrast to a previously explored finite interval case, there is a range of parameters for which a bidirectional search strategy is more efficient than a unidirectional one in finding the target.
Newby
Jay M
JM
Department of Mathematics, University of Utah, Salt Lake City, Utah 84112, USA.
Bressloff
Paul C
PC
D001692:Biological Transport; D003712:Dendrites / Q000378:metabolism*; D008870:Microtubules / Q000378:metabolism; D008959:Models, Neurological; D011336:Probability; D013269:Stochastic Processes