Bioactive scalaranes from the Thai sponge Hyrtios gumminae.
Chemical investigation of the Thai sponge Hyrtios gumminae collected from Similan Island in the Andaman Sea, Thailand, yielded four new sesterterpenoids, similan A (1), 12beta,20-dihydroxy-16beta-acetoxy-17-scalaren-19,20-olide (2), 12beta-acetoxy-20-hydroxy-17-scalaren-19,20-olide (3), and 12beta,16alpha,20-trihydroxy-17-scalaren-19,20-olide (4), together with seven known compounds. The structures of these new compounds were elucidated on the basis of their spectroscopic data and chemical transformations. Some of the isolated compounds were tested for their cytotoxic activity.
Chulabhorn Research Institute, Vipavadee Rangsit Highway, Bangkok 10210, Thailand.
Chulabhorn
C
Mahidol
Hunsa
H
Prawat
Suwannee
S
Sangpetsiripan
Somsak
S
Ruchirawat
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry*; D054830:Sesterterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013237:Stereoisomerism; D013785:Thailand
D000970:Antineoplastic Agents; D054830:Sesterterpenes