Variation in the perilipin gene (PLIN) affects glucose and lipid metabolism in non-Hispanic white women with and without polycystic ovary syndrome.
Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women. It is characterized by chronic anovulation, hyperandrogenism, obesity and a predisposition to type 2 diabetes mellitus (T2DM). Since obesity plays an important role in the etiology of PCOS, we sought to determine if variants in the perilipin gene (PLIN), a gene previously implicated in the development of obesity, were also associated with PCOS. We typed six single nucleotide polymorphisms (haplotype tagging and/or previously associated with obesity or related metabolic traits) in PLIN in 305 unrelated non-Hispanic white women (185 with PCOS and 120 without PCOS). None of the variants was associated with PCOS (P<0.05). However, the variant rs1052700*A was associated with increased risk for glucose intolerance (impaired glucose tolerance or T2DM) in both non-PCOS (OR=1.75 [1.02-3.01], P=0.044) and PCOS subjects (OR=1.67 [1.08-2.59], P=0.022). It was also associated with increased LDL (P=0.007) and total cholesterol levels (P=0.042). These results suggest that genetic variation in PLIN may affect glucose and lipid metabolism in women both with and without PCOS.
Department of Medicine, The University of Chicago, Chicago, IL 60637, USA. tkawai@sc.itc.keio.ac.jp
Toshihide
T
Kawai
Maggie C Y
MC
Ng
M Geoffrey
MG
Hayes
Issei
I
Yoshiuchi
Takafumi
T
Tsuchiya
Heather
H
Robertson
Nancy J
NJ
Cox
Kenneth S
KS
Polonsky
Graeme I
GI
Bell
David A
DA
Ehrmann
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D015992:Body Mass Index; D002352:Carrier Proteins; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics; D005260:Female; D014644:Genetic Variation; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000097:blood; D008055:Lipids / Q000097:blood / Q000502:physiology*; D000070778:Perilipin-1; D010750:Phosphoproteins / Q000235:genetics*; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000235:genetics*; D044465:White People / Q000235:genetics*
D001786:Blood Glucose; D002352:Carrier Proteins; D006442:Glycated Hemoglobin; D007328:Insulin; D008055:Lipids; D000070778:Perilipin-1; D010750:Phosphoproteins