Sleep disturbances and frailty status in older community-dwelling men.
OBJECTIVE
To test the hypothesis that sleep disturbances are independently associated with frailty status in older men.


METHODS
Cross-sectional analysis of prospective cohort study.


METHODS
Six U.S. centers.


METHODS
Three thousand one hundred thirty-three men aged 67 and older.


METHODS
Self-reported sleep parameters (questionnaire); objective parameters of sleep-wake patterns (actigraphy data collected for an average of 5.2 nights); and objective parameters of sleep-disordered breathing, nocturnal hypoxemia, and periodic leg movements with arousals (PLMAs) (in-home overnight polysomnography). Frailty status was classified as robust, intermediate stage, or frail using criteria similar to those used in the Cardiovascular Health Study frailty index.


RESULTS
The prevalence of sleep disturbances, including poor sleep quality, excessive daytime sleepiness, short sleep duration, lower sleep efficiency, prolonged sleep latency, sleep fragmentation (greater nighttime wakefulness and frequent, long wake episodes), sleep-disordered breathing, nocturnal hypoxemia, and frequent PLMAs, was lowest in robust men, intermediate in men in the intermediate-stage group, and highest in frail men (P-for-trend < or =.002 for all sleep parameters). After adjusting for multiple potential confounders, self-reported poor sleep quality (Pittsburgh Sleep Quality Index > 5, multivariable odds ratio (MOR)=1.28, 95% confidence interval (CI)=1.09-1.50), sleep efficiency less than 70% (MOR=1.37, 95% CI=1.12-1.67), sleep latency of 60 minutes or longer (MOR=1.42, 95% CI=1.10-1.82), and sleep-disordered breathing (respiratory disturbance index > or =15, MOR=1.38, 95% CI=1.15-1.65) were each independently associated with higher odds of greater frailty status.


CONCLUSIONS
Sleep disturbances, including poor self-reported sleep quality, lower sleep efficiency, prolonged sleep latency, and sleep-disordered breathing, are independently associated with greater evidence of frailty.
Center for Chronic Disease Outcomes Research, Veterans Affairs Medical Center, Minneapolis, Minnesota 55417, USA. ensru001@umn.edu
Kristine E
KE
Ensrud
Terri L
TL
Blackwell
Susan
S
Redline
Sonia
S
Ancoli-Israel
Misti L
ML
Paudel
Peggy M
PM
Cawthon
Thuy-Tien L
TT
Dam
Elizabeth
E
Barrett-Connor
Ping C
PC
Leung
Katie L
KL
Stone
D000368:Aged; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D016330:Frail Elderly / Q000706:statistics & numerical data*; D015577:Geriatric Assessment; D006801:Humans; D000860:Hypoxia / Q000453:epidemiology; D057187:Independent Living; D008297:Male; D020189:Nocturnal Myoclonus Syndrome / Q000453:epidemiology; D017286:Polysomnography; D020181:Sleep Apnea, Obstructive / Q000453:epidemiology; D007319:Sleep Initiation and Maintenance Disorders / Q000453:epidemiology; D012893:Sleep Wake Disorders / Q000453:epidemiology*; D014481:United States