Insertion/deletion polymorphism in the promoter region of NFKB1 gene increases susceptibility for superficial bladder cancer in Chinese.
Recently, a functional insertion/deletion polymorphism (-94 insertion/deletion ATTG) in the promoter of NFKB1 gene, which encodes the p50 subunit of nuclear factor-kappaB protein complex, was identified. The aim of this study was to explore the association between this polymorphism and bladder cancer in a Chinese population. The NFKB1 polymorphism was assessed in 207 patients with superficial transitional cell carcinomas in bladder and in 228 age-, sex-, and smoking-matched healthy volunteers. The polymerase chain reaction assay was used to determine the NFKB1 genotypes. Genomic DNA used for the assay was extracted from peripheral blood lymphocytes. This study found that the frequency of ATTG(2) allele in bladder cancer patients was significantly higher than that in control subjects (65.2% vs. 56.1%, p = 0.006, odds ratio = 1.465), suggesting that the functional NFKB1 promoter polymorphism is associated with increased risk for superficial transitional cell carcinoma of the bladder.
Department of Urology, Affiliated Hospital of North Sichuan Medical College, Nanchong, People's Republic of China.
Tielong
T
Tang
Shu
S
Cui
Xianzhong
X
Deng
Zhiyong
Z
Gong
Guo
G
Jiang
Pingxi
P
Wang
Bo
B
Liao
Zhonghai
Z
Fei
Shuyan
S
Xian
Denang
D
Zeng
Jianyong
J
Li
D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics; D002277:Carcinoma / Q000235:genetics*; D002681:China; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D054643:INDEL Mutation; D008297:Male; D008875:Middle Aged; D052002:NF-kappa B p50 Subunit / Q000235:genetics*; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic / Q000235:genetics; D001749:Urinary Bladder Neoplasms / Q000235:genetics*
D052002:NF-kappa B p50 Subunit; C489548:NFKB1 protein, human