[Junctophilin, a molecule that couples endo (sarco) plasma membrane to cell membrane].
Junctophilin is a molecule that couples endo (sarco) plasma membrane to plasma membrane in excitable cells. Its C terminal anchors into the endo (sarco) plasmic reticulum, while its N terminal interacts with plasma membrane via the MORN motifs. Mammalian junctophilin has four subtypes, among which Jp-1 and Jp-2 exist mainly in skeletal and cardiac muscle, respectively. In muscle cells, low expression of junctophilin decouples the sarcoplasmic reticulum from plasma membrane, decreases the efficiency of excitation-contraction coupling efficiency, and thereby compromises the contractility of heart and muscles. Many human diseases such as heart failure accompany with junctophilin mutations, so junctophilin may become a new target against these diseases.
Zhang
Peng
P
College of Life Sciences, Peking University, Beijing 100871, China.
Yu
Yue
Y
Wang
Shi-Qiang
SQ
D000818:Animals; D002118:Calcium / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism*; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism*; D012519:Sarcoplasmic Reticulum / Q000378:metabolism*
D008565:Membrane Proteins; C412507:junctophilin; D002118:Calcium