Effect of treatment with losartan on salt sensitivity and SGLT2 expression in hypertensive diabetic rats.
Sodium-glucose cotransporters (SGLTs) in the kidney, may be involved in hypertension, diabetes and salt sensitivity. We evaluate the effect of losartan on blood pressure (BP) and SGLT2 expression in diabetic rats with high or normal salt diet. Losartan prevented an increase in BP and SGLT2 expression in diabetic rats.
Osorio
Horacio
H
Department of Molecular Biomedicine, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV) México City, Mexico.
Bautista
Rocío
R
Rios
Amelia
A
Franco
Martha
M
Santamaría
José
J
Escalante
Bruno
B
D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001794:Blood Pressure; D048909:Diabetes Complications / Q000188:drug therapy*; D003921:Diabetes Mellitus, Experimental / Q000150:complications / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D004231:Diuresis; D005786:Gene Expression Regulation; D005919:Glomerular Filtration Rate; D006973:Hypertension / Q000150:complications / Q000188:drug therapy* / Q000235:genetics / Q000503:physiopathology; D007672:Kidney Cortex / Q000473:pathology; D019808:Losartan / Q000627:therapeutic use*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D044140:Receptor, Angiotensin, Type 1 / Q000187:drug effects / Q000502:physiology; D012982:Sodium, Dietary; D051297:Sodium-Glucose Transporter 2 / Q000235:genetics*
D000959:Antihypertensive Agents; D044140:Receptor, Angiotensin, Type 1; C490300:Slc5a2 protein, rat; D012982:Sodium, Dietary; D051297:Sodium-Glucose Transporter 2; D019808:Losartan