G-CSF and GM-CSF as therapeutic targets in rheumatoid arthritis.
Granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) are well-recognized regulators of hematopoiesis and have an established role as growth factors in clinical practice. G-CSF and GM-CSF regulate myeloid cell production, differentiation and activation, and might also be important for driving inflammatory responses. Inappropriate engagement of this pathway could be a critical amplification mechanism when maladaptive immune responses predispose to autoimmunity and sterile tissue inflammation. We postulate that antagonism of G-CSF or GM-CSF could represent a novel therapeutic approach for a variety of autoimmune-mediated inflammatory diseases, including rheumatoid arthritis.
Cornish
Ann L
AL
Autoimmunity and Transplantation Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Vic, Australia.
Campbell
Ian K
IK
McKenzie
Brent S
BS
Chatfield
Simon
S
Wicks
Ian P
IP
D000818:Animals; D018501:Antirheumatic Agents / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism; D004195:Disease Models, Animal; D015195:Drug Design; D016179:Granulocyte Colony-Stimulating Factor / Q000037:antagonists & inhibitors / Q000502:physiology*; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000037:antagonists & inhibitors / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000503:physiopathology; D018836:Inflammation Mediators / Q000627:therapeutic use; D009504:Neutrophils / Q000502:physiology
D018501:Antirheumatic Agents; D018836:Inflammation Mediators; D016179:Granulocyte Colony-Stimulating Factor; D016178:Granulocyte-Macrophage Colony-Stimulating Factor