Fibroblast growth factor 23 and its role in phosphate homeostasis.
Phosphate homeostasis is complex and incompletely understood. The identification of different factors involved in the regulation of phosphate balance, also called phosphatonins, has largely changed our view on the regulation of phosphate homeostasis. The active role of bone has been demonstrated clearly. Currently, maintaining phosphate homeostasis is considered the result of a complex network of endocrine feedback loops between parathyroid gland, kidney, and bone. This review describes current knowledge on fibroblast growth factor 23, which is one of the best studied phosphatonins.
Ramon
Isolde
I
Department of Internal Medicine-Endocrinology, Brugmann University Hospital, Free University of Brussels, Brussels, Belgium. iramon06@hotmail.com
Kleynen
Pierre
P
Body
Jean-Jacques
JJ
Karmali
Rafik
R
D000818:Animals; D055098:Endocrine Cells / Q000166:cytology / Q000378:metabolism; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D006706:Homeostasis / Q000235:genetics / Q000502:physiology*; D006801:Humans; D007668:Kidney / Q000378:metabolism / Q000502:physiology; D010012:Osteogenesis / Q000235:genetics / Q000502:physiology; D010710:Phosphates / Q000378:metabolism / Q000502:physiology* / Q000652:urine
D010710:Phosphates; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23