Manufacture of pharmaceutical co-crystals using twin screw extrusion: a solvent-less and scalable process.
Medina
Cesar
C
Small Molecule Process and Product Development, Amgen Inc., Thousand Oaks, California 91320, USA.
Daurio
Dominick
D
Nagapudi
Karthik
K
Alvarez-Nunez
Fernando
F
D052160:Benzothiazoles / Q000737:chemistry; D002110:Caffeine / Q000737:chemistry; D003460:Crystallization / Q000379:methods*; D004339:Drug Compounding / Q000379:methods*; D019815:Oxalic Acid / Q000737:chemistry; D011743:Pyrimidines / Q000737:chemistry; D012995:Solubility; D013011:Sorbic Acid / Q000737:chemistry; D014961:X-Ray Diffraction
D052160:Benzothiazoles; C523409:N-(4-(6-(4-trifluoromethylphenyl)pyrimidin-4-yloxy)benzothiazol-2-yl)acetamide; D011743:Pyrimidines; D002110:Caffeine; D019815:Oxalic Acid; D013011:Sorbic Acid