Omeprazole-induced cough in a patient with gastroesophageal reflux disease.
Persistent cough could be caused by various diseases such as postnasal drip syndrome, asthma and gastroesophageal reflux disease (GERD) or adverse event of drugs such as angiotensin-converting enzyme inhibitors. We report a case of persistent cough associated with high plasma levels of the proton pump inhibitor omeprazole in a patient with GERD. This case suggests cough as an adverse drug event to omeprazole, which is otherwise commonly prescribed for the management of GERD-related cough. Therefore, physicians should be aware of the onset or an exacerbation of cough during omeprazole therapy.
Reiche
Ines
I
Institute of Clinical Pharmacology, Otto-von-Guericke University, Magdeburg, Germany. ines.reiche@med.ovgu.de
Tröger
Uwe
U
Martens-Lobenhoffer
Jens
J
Kandulski
Arne
A
Neumann
Helmut
H
Malfertheiner
Peter
P
Bode-Böger
Stefanie M
SM
D000368:Aged; D003371:Cough / Q000139:chemically induced* / Q000175:diagnosis / Q000209:etiology; D005260:Female; D005764:Gastroesophageal Reflux / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D009853:Omeprazole / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use; D054328:Proton Pump Inhibitors / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use
D054328:Proton Pump Inhibitors; D009853:Omeprazole