Expression of the psoriasis-associated antigen, Pso p27, is inhibited by traditional Chinese medicine.
OBJECTIVE
Pso p27 is shown to be an autoantigen in psoriasis and the objective of the present study was to investigate whether Traditional Chinese Medicine (TCM) would influence the expression of Pso p27.


METHODS
Skin biopsies obtained from psoriatic patients before and after treatment with TCM were analyzed for the presence of Pso p27 antigen by indirect immunofluorescence using murine monoclonal antibodies against Pso p27.


RESULTS
A significant reduction in the amount of Pso p27 in the psoriatic skin was obtained after treatment with TCM for 3 months.


CONCLUSIONS
The presence of Pso p27 in psoriatic skin is reduced when psoriatic patients are treated with TCM.
Department of Dermatology, Guang An'men Hospital, China Academy of Chinese Medical Sciences, No 5 Beixiange Street, Xuan Wu District, Beijing, China. songping@medmail.com.cn
Ping
P
Song
Hilde
H
Lysvand
Yan
Y
Yuhe
Wali
W
Liu
Ole-Jan
OJ
Iversen
D000208:Acute Disease; D000279:Administration, Cutaneous; D000284:Administration, Oral; D000941:Antigens / Q000276:immunology / Q000378:metabolism*; D001324:Autoantigens / Q000276:immunology / Q000378:metabolism*; D001494:Baths; D001628:Beverages; D001706:Biopsy; D002908:Chronic Disease; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008856:Microscopy, Fluorescence; D009824:Ointments / Q000494:pharmacology / Q000627:therapeutic use; D011565:Psoriasis / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D012720:Severity of Illness Index; D012867:Skin / Q000187:drug effects* / Q000473:pathology; D016896:Treatment Outcome
D000941:Antigens; D001324:Autoantigens; D004365:Drugs, Chinese Herbal; D009824:Ointments; C097643:antigen pso p27