How DISC1 regulates postnatal brain development: girdin gets in on the AKT.
In this issue of Neuron, Kim et al. and Enomoto et al. show that DISC1 plays a key role in regulating postnatal brain development though interaction with Girdin. Girdin in turn regulates AKT signaling. Thus, another facet of the role of DISC1 is established, shedding more light on fundamental brain processes and the developmental basis of major psychiatric disorders.
Medical Genetics Section, Molecular Medicine Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, EH4 2XU, Edinburgh, UK. david.porteous@ed.ac.uk
David
D
Porteous
Kirsty
K
Millar
D000818:Animals; D001921:Brain / Q000254:growth & development*; D051379:Mice; D008840:Microfilament Proteins / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism*; D033921:Vesicular Transport Proteins / Q000378:metabolism*
D008840:Microfilament Proteins; D009419:Nerve Tissue Proteins; D051057:Proto-Oncogene Proteins c-akt; D033921:Vesicular Transport Proteins; C498794:Disc1 protein, mouse; C527550:Ccdc88a protein, mouse