Nanolobatolide, a new C18 metabolite from the Formosan soft coral Sinularia nanolobata.
Nanolobatolide (1), possessing a novel C(18) molecular structure, was isolated from the Formosan soft coral Sinularia nanolobata. The structure of 1 was established by extensive spectroscopic study and confirmed by X-ray diffraction analysis. A plausible biosynthetic pathway of 1 was proposed. Nanolobatolide (1) has been found to possess significant anti-neuroinflammatory and neuroprotective activities.
Tseng
Yen-Ju
YJ
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
Wen
Zhi-Hong
ZH
Dai
Chang-Feng
CF
Chiang
Michael Y
MY
Sheu
Jyh-Horng
JH
D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001952:Bridged-Ring Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D052246:Cyclooxygenase 2 Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D017628:Microglia / Q000187:drug effects; D008968:Molecular Conformation; D015394:Molecular Structure; D018696:Neuroprotective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D052247:Nitric Oxide Synthase Type II / Q000187:drug effects*
D000893:Anti-Inflammatory Agents; D001952:Bridged-Ring Compounds; D052246:Cyclooxygenase 2 Inhibitors; D018696:Neuroprotective Agents; C545969:nanolobatolide; D052247:Nitric Oxide Synthase Type II