Current applications and future potential for bioinorganic chemistry in the development of anticancer drugs.
This review illustrates notable recent progress in the field of medicinal bioinorganic chemistry as many new approaches to the design of innovative metal-based anticancer drugs are emerging. Current research addressing the problems associated with platinum drugs has focused on other metal-based therapeutics that have different modes of action and on prodrug and targeting strategies in an effort to diminish the side-effects of cisplatin chemotherapy.
Department of Chemistry, University of Warwick, Coventry, UK.
Sabine H
SH
van Rijt
Peter J
PJ
Sadler
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D015393:Chemistry, Bioinorganic / Q000639:trends*; D056831:Coordination Complexes / Q000737:chemistry / Q000494:pharmacology; D016503:Drug Delivery Systems; D055808:Drug Discovery; D004354:Drug Screening Assays, Antitumor; D005544:Forecasting; D006801:Humans; D015394:Molecular Structure; D011355:Prodrugs / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D056831:Coordination Complexes; D011355:Prodrugs