A new antimicrobial fatty acid from the calcareous sponge Paragrantia cf. waguensis.
A new acetylenic fatty acid, 1, has been isolated from the title sponge. The structure of the molecule was elucidated to contain an enyne and a thiophene by spectroscopic methods. Compound 1 showed a weak cytotoxic effect against NBT-T2 rat bladder epithelial cells (IC(50) > 20 microg/ml), and antimicrobial activity with minimal-inhibitory concentrations (MIC) of 64 and 128 microg/ml against Staphylococcus aureus and Escherichia coli, respectively.
Tianero
Ma Diarey B
MD
Department of Chemistry, Biology, and Marine Science, University of the Ryukyus, Nishihara, Okinawa 903-0213, Japan.
Hanif
Novriyandi
N
de Voogd
Nicole J
NJ
van Soest
Rob W M
RW
Tanaka
Junichi
J
D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D002460:Cell Line; D005231:Fatty Acids, Unsaturated / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D008826:Microbial Sensitivity Tests; D011161:Porifera / Q000737:chemistry*; D051381:Rats; D013876:Thiophenes / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity
C546093:6-(5-((5E)-oct-5-en-7-ynyl)thiophen-2-yl)hex-5-ynoic acid; D000890:Anti-Infective Agents; D005231:Fatty Acids, Unsaturated; D013876:Thiophenes