Biological activity of a phloroglucinol glucoside derivative from Conyza aegyptiaca.
The phloroglucinol glucoside derivative [2,4-dihydroxy-6-(beta-D-glucopyranosyloxy)phenyl]-butan-1-one (1), roseoside (2), and kaempferol-3-O-beta-D-glucopyranoside (3) were isolated from the aerial parts of Conyza aegyptiaca (L.). To the best of our knowledge, this is the first isolation of compounds 1-3 from C. aegyptiaca. Their structures were determined by spectroscopic techniques including, IR, HR-EIMS, and extensive 500 MHz 1D- and 2D-NMR analyses (1H, 13C NMR, DEPT, 1H-1H COSY, HMQC and HMBC experiments). The antioxidant activity of 1, using the DPPH assay, was investigated; in addition, 1 was investigated against different types of cell lines, including Hep-G2, HCT-116, and RAW 264.7 for its cytotoxic effects. Also, this is the first report on the activity of 1.
Mahmoud
Ahmed A
AA
Chemistry Department, College of Science, King Faisal University, P. O. Box 1759, Hofuf 380, Saudi Arabia.
Al-Shihry
Shar S
SS
Hegazy
Mohamed-Elamir F
ME
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D001713:Biphenyl Compounds / Q000737:chemistry; D006528:Carcinoma, Hepatocellular; D045744:Cell Line, Tumor / Q000187:drug effects; D003110:Colonic Neoplasms; D035401:Conyza / Q000737:chemistry*; D004534:Egypt; D005960:Glucosides / Q000302:isolation & purification / Q000494:pharmacology; D008113:Liver Neoplasms; D008264:Macrophages / Q000187:drug effects / Q000502:physiology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D008958:Models, Molecular; D010696:Phloroglucinol / Q000302:isolation & purification* / Q000494:pharmacology; D010851:Picrates / Q000737:chemistry; D035261:Plant Components, Aerial / Q000737:chemistry
D000975:Antioxidants; D001713:Biphenyl Compounds; D005960:Glucosides; D010851:Picrates; C004931:1,1-diphenyl-2-picrylhydrazyl; D010696:Phloroglucinol