Susceptibility to urinary bladder cancer: relevance of rs9642880[T], GSTM1 0/0 and occupational exposure.
Recently, a genome-wide single nucleotide polymorphism association study has identified a sequence variant 30 kb upstream of the c-Myc gene (allele T of rs9642880) that confers susceptibility to bladder cancer. However, the role of exposure to bladder carcinogens has not been considered. This prompted us to analyse the relevance of this polymorphism in 515 bladder cancer cases and 893 controls where the quality and quantity of occupational exposure to bladder carcinogens has been documented. When we analysed a hospital-based case-control series not selected for occupational exposure, rs9642880[T] was influential, in contrast to GSTM1 0/0. However, in a case-control series of patients that have been occupationally exposed to aromatic amines and polycyclic aromatic hydrocarbons, rs9642880[T] was not influential but GSTM1 0/0 was significantly associated with bladder cancer risk. Therefore, the degree to which rs9642880[T] and GSTM1 0/0 confer susceptibility to urinary bladder cancer seems to depend on the extent of exposure to urinary bladder carcinogens.
Golka
Klaus
K
Leibniz Research Centre for Working Environment and Human Factors (IfADo), Ardeystrasse, Dortmund, Germany. Golka@ifado.de
Hermes
Matthias
M
Selinski
Silvia
S
Blaszkewicz
Meinolf
M
Bolt
Hermann M
HM
Roth
Gerhard
G
Dietrich
Holger
H
Prager
Hans-Martin
HM
Ickstadt
Katja
K
Hengstler
Jan G
JG
D020022:Genetic Predisposition to Disease; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D016273:Occupational Exposure / Q000032:analysis*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D001749:Urinary Bladder Neoplasms / Q000201:enzymology* / Q000235:genetics*
D005982:Glutathione Transferase