Synchrotron X-ray imaging via ultra-small-angle scattering: principles of quantitative analysis and application in studying bone integration to synthetic grafting materials.
Optimized experimental conditions for extracting accurate information at subpixel length scales from analyzer-based X-ray imaging were obtained and applied to investigate bone regeneration by means of synthetic beta-TCP grafting materials in a rat calvaria model. The results showed a 30% growth in the particulate size due to bone ongrowth/ingrowth within the critical size defect over a 1-month healing period.
Morelhão
Sérgio L
SL
Instituto de Física, Universidade de São Paulo, São Paulo, SP, Brazil. morelhao@if.usp.br
Coelho
Paulo G
PG
Hönnicke
Marcelo G
MG
D000465:Algorithms; D000818:Animals; D018786:Bone Substitutes; D016025:Bone Transplantation / Q000295:instrumentation*; D016348:Osseointegration / Q000502:physiology*; D051381:Rats; D053838:Scattering, Small Angle; D012886:Skull / Q000503:physiopathology* / Q000601:surgery*; D017356:Synchrotrons; D014961:X-Ray Diffraction / Q000379:methods*
D018786:Bone Substitutes