Pulmonary crystal-storing histiocytoma in a patient without a lymphoproliferative disorder.
Pulmonary crystal-storing histiocytoma is a very rare disorder and is characterized by infiltration of histiocytes with intracytoplasmic accumulation of crystallized immunoglobulins. It is usually associated with lymphoproliferative diseases or plasma cell dyscrasia. Here, we report a case of pulmonary crystal-storing histiocytoma in a 64-year-old man, presenting as a chronic pulmonary consolidation in the lung exposed to asbestos. Video-assisted thoracoscopic surgical biopsy displayed sheets of large, epithelioid histiocytes filled with a large number of needle-like crystals, showing the accumulation of crystallized polyclonal immunoglobulins. This lesion was consistent with crystal-storing histiocytosis or crystal-storing histiocytoma. With extensive clinical work-up, the current case was not associated with lymphoproliferative diseases. Herein, we present this extremely rare entity of pulmonary pathology, a pulmonary crystal-storing histiocytoma arising in the lung exposed to asbestos, and demonstrate the clinical, radiologic, and pathologic features of the tumor.
Departments of Internal Medicine and Research Center for Pulmonary Disorders, Chonbuk National University Medical School, Jeonju, South Korea.
Won Seok
WS
Lee
So Ri
SR
Kim
Hee
H
Moon
Yeong Hun
YH
Choe
Seoung Ju
SJ
Park
Heung Bum
HB
Lee
Gong Yong
GY
Jin
Myoung Ja
MJ
Chung
Yong Chul
YC
Lee
D001194:Asbestos / Q000633:toxicity*; D003460:Crystallization; D003937:Diagnosis, Differential; D006644:Histiocytes / Q000737:chemistry / Q000473:pathology / Q000648:ultrastructure; D051642:Histiocytoma / Q000139:chemically induced* / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D007070:Immunoglobulin A / Q000737:chemistry / Q000648:ultrastructure; D007074:Immunoglobulin G / Q000737:chemistry / Q000648:ultrastructure; D008175:Lung Neoplasms / Q000139:chemically induced* / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D008232:Lymphoproliferative Disorders / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects*; D011859:Radiography; D020775:Thoracic Surgery, Video-Assisted
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D001194:Asbestos