Association between mannose-binding lectin and HIV infection and progression in a Chinese population.
Mannose-binding lectin (MBL) is a circulating pattern recognition molecule involved in the innate immune system that mediates phagocytosis and activates complement by binding to a carbohydrate extremity. Some MBL genetic polymorphisms result in deficient protein levels and increased susceptibility to infection. The objective of this study was to investigate the association between MBL2 exon 1 polymorphisms, serum levels of normal MBL, and HIV-1 infection and progression in a Chinese population. A total of 1075 adult patients infected with HIV-1 (532 male and 543 female) were recruited. The genotype of 145 patients was determined and the genotype frequencies compared with healthy population controls. The disease status of patients was evaluated for different MBL2 genotypes and normal MBL serum levels. MBL2 exon 1 polymorphisms (A/O or O/O) were significantly more common in HIV-1-infected patients than in the healthy controls. Patients in clinical categories B/C with severe diseases were significantly more likely to have one variant allele. There was a statistical relationship between MBL2 genotypes and MBL serum levels. In addition, higher CD4(+) T cell counts and ratios of CD4(+) T cells:CD8(+) T cells were observed in patients with medium MBL levels than with low or high MBL levels. Patients with mild diseases were also more likely to have medium MBL levels than high levels. Analysis of MBL levels with respect to sex yielded differences. Median MBL levels were substantially higher in males than in females in HIV-1-infected patients. Lower CD4(+) T cell counts were detected in males with low MBL levels, but the opposite was observed in females. Our results suggest that genetic polymorphisms resulting in MBL deficiency are associated with increased susceptibility to HIV-1 infection and disease progression in the studied population. Moreover, serum circulating levels of normal MBL in HIV-1-infected patients could be an important auxiliary biological marker in association with CD4(+) T cell counts in the evaluation of HIV-1 disease progression. The sex differences in the regulation of MBL serum levels during infection merit further exploration.
Tan
Yajun
Y
Division of Serum, National Institute for the Control of Pharmaceutical and Biological Products, Beijing, China.
Liu
Lifeng
L
Luo
Peng
P
Wang
Anxu
A
Jia
Tianjun
T
Shen
Xinliang
X
Wang
Man
M
Zhang
Shumin
S
D000293:Adolescent; D000328:Adult; D000368:Aged; D044466:Asian People; D015415:Biomarkers; D016022:Case-Control Studies; D002681:China; D018450:Disease Progression; D005091:Exons / Q000235:genetics; D005260:Female; D005838:Genotype; D015658:HIV Infections / Q000097:blood / Q000276:immunology* / Q000473:pathology*; D006304:Health Status; D006801:Humans; D008297:Male; D037601:Mannose-Binding Lectin / Q000097:blood* / Q000235:genetics / Q000276:immunology; D008875:Middle Aged
D015415:Biomarkers; C445619:MBL2 protein, human; D037601:Mannose-Binding Lectin