Respiratory-swallow phase patterns and their relationship to swallowing impairment in patients treated for oropharyngeal cancer.
BACKGROUND
Unstable respiratory-swallowing coordination has been associated with disorders and disease. The goals of this study were (1) to describe respiratory-swallow patterns in patients with dysphagia consequent to treatments for cancers of the oropharynx and (2) to determine the association between respiratory-swallow patterns, airway invasion, and overall severity of swallowing impairment.


METHODS
This prospective, cross-sectional design compared respiratory-swallow patterns in 20 patients treated for oropharyngeal cancer and 20 healthy, age-matched control participants. Nasal airflow direction was synchronously recorded with videofluoroscopic imaging in participants who swallowed 5-mL thin liquid barium boluses.


RESULTS
Respiratory-swallow patterns differed between groups. Most control participants initiated and completed swallowing bracketed by expiratory airflow. Swallowing in patients often interrupted inspiratory flow and was associated with penetration or aspiration of the bolus.


CONCLUSIONS
We suggest nonexpiratory bracketed respiratory-swallowing phase patterns in patients with oropharyngeal cancer may place patients at greater risk of airway penetration or aspiration during swallowing.
Brodsky
Martin B
MB
Department of Physical Medicine and Rehabilitation, Johns Hopkins University, Baltimore, Maryland, USA.
McFarland
David H
DH
Dozier
Thomas S
TS
Blair
Julie
J
Ayers
Christopher
C
Michel
Yvonne
Y
Gillespie
M Boyd
MB
Day
Terry A
TA
Martin-Harris
Bonnie
B
D000328:Adult; D000368:Aged; D001466:Barium Sulfate; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D003430:Cross-Sectional Studies; D003679:Deglutition / Q000502:physiology*; D003680:Deglutition Disorders / Q000175:diagnosis / Q000209:etiology; D005260:Female; D005471:Fluoroscopy / Q000379:methods; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009959:Oropharyngeal Neoplasms / Q000150:complications / Q000473:pathology / Q000628:therapy*; D009960:Oropharynx / Q000187:drug effects / Q000528:radiation effects / Q000601:surgery*; D011183:Postoperative Complications / Q000175:diagnosis / Q000628:therapy; D011336:Probability; D011446:Prospective Studies; D018714:Radiotherapy, Adjuvant; D012016:Reference Values; D053120:Respiratory Aspiration / Q000175:diagnosis* / Q000209:etiology; D014741:Video Recording
D001466:Barium Sulfate