Non-Linear Optical Imaging of Obesity-Related Health Risks: Review.
This review highlights the recent applications of non-linear optical (NLO) microscopy to study obesity-related health risks. A strong emphasis is given to the applications of coherent anti-Stokes Raman scattering (CARS) microscopy where multiple non-linear optical imaging modalities including CARS, sum-frequency generation (SFG), and two-photon fluorescence are employed simultaneously on a single microscope platform. Specific examples on applications of NLO microscopy to study lipid-droplet biology, obesity-cancer relationship, atherosclerosis, and lipid-rich biological structures are discussed.
Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana 47907, USA, thuc@purdue.edu.
Thuc T
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Le
Ji-Xin
JX
Cheng