Two new acorane sesquiterpenes from Illicium henryi.
Two new acorane sesquiterpenes, 10-hydroxyacoronene (1) and 1beta-isopropyl-4beta-methyl-9beta-hydroxy spiro[4.5]dec-6-en-8-one (2), one new natural product, 4-hydroxy-4, 6-dimethyl-1-tetralone (3), and one known acorane sesquiterpene, acoradiepoxide (4) were isolated from the twigs and leaves of Illicium henryi. The structures of the new compounds were elucidated primarily on the basis of analysis of spectroscopic data. In addition, the inhibitory effect on NO production of these compounds were tested. Compounds 1 and 4 exhibited slight inhibitory effects on NO production with IC50 values of 82.4 microg/mL and 76.5 microg/mL, respectively.
Song
Tai-Fa
TF
Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China.
Zhang
Wei-Dong
WD
Xia
Xin-Hua
XH
Shen
Yun-Heng
YH
Liu
Chun-Mei
CM
Lin
Sheng
S
Jin
Hui-zi
HZ
Li
Hui-Liang
HL
D000818:Animals; D002478:Cells, Cultured; D029523:Illicium / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D009569:Nitric Oxide / Q000096:biosynthesis; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D012717:Sesquiterpenes; D009569:Nitric Oxide