AAA proteases in mitochondria: diverse functions of membrane-bound proteolytic machines.
FtsH/AAA proteases comprise a distinct family of membrane-bound, ATP-dependent proteases present in eubacteria and eukaryotic cells, where they are confined to mitochondria and chloroplasts. Here, we will summarize versatile functions of AAA proteases within mitochondria, which ensure mitochondrial integrity and cell survival, acting both as quality control and processing enzymes.
Institute for Genetics, Centre for Molecular Medicine (CMMC), Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, D-50674 Cologne, Germany. t.tatsuta@uni-koeln.de
Takashi
T
Tatsuta
Thomas
T
Langer
D049069:ATP-Dependent Proteases / Q000378:metabolism*; D001419:Bacteria / Q000201:enzymology*; D055162:Biocatalysis; D005057:Eukaryotic Cells / Q000201:enzymology; D008928:Mitochondria / Q000201:enzymology*; D000091402:Prohibitins; D012097:Repressor Proteins / Q000378:metabolism; D013379:Substrate Specificity
D000091402:Prohibitins; D012097:Repressor Proteins; D049069:ATP-Dependent Proteases