Measurement of cystatin C in capillary blood samples in pediatric patients.
We assessed whether the GFR marker cystatin C can be measured reliably in capillary blood samples in children with renal disease. Cystatin C was measured in venous and capillary blood samples obtained simultaneously from 48 children, and GFR was estimated using the Filler equation. Estimated GFR based on capillary cystatin C concentrations was higher than the venous cystatin C based GFR. The limits of agreement between estimated GFR based on capillary and venous measurements exceeded +/-20% at the upper reference concentration, which hampers the clinical usefulness of capillary sampling.
Department of Pediatrics, VU University Medical Center, Amsterdam, The Netherlands, De Boelelaan 1117, 1081 HV, The Netherlands.
Arend W
AW
van Deutekom
Berndt
B
Zur
Joanna A E
JA
van Wijk
Anna A
AA
Bouman
Arend
A
Bökenkamp
D000293:Adolescent; D015415:Biomarkers / Q000097:blood*; D002196:Capillaries / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D055316:Cystatin C / Q000097:blood*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007223:Infant; D007674:Kidney Diseases / Q000097:blood*; D008297:Male; D055815:Young Adult
D015415:Biomarkers; D055316:Cystatin C