[Humoral immune response in experimental animals exposed to organic and inorganic compounds].
A humoral immune response was studied in the Wistar rats and (CBAxC57B16)F1 mice orally given potassium bichromate, benzene, and their mixture with drinking water. The test substances were found to have an immunosuppressive effect on both the parameters of an immune response and the level of lysozyme in the experimental animals, which appeared as reductions in the number of splenocytes in the rats, the relative count of antibody-forming cells in the mice, the absolute count of AFC on the spleen in the rats and mice, the level of hemagglutinins in the rats, and that of lysozyme in the rats and mice. Benzene and a mixture of benzene and potassium bichromate showed the most marked immunosuppressive effect on these animals.
Mikhaĭlova
I V
IV
Kislinskaia
E S
ES
Pushkareva
L A
LA
Rumiantseva
A V
AV
D000284:Administration, Oral; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D001554:Benzene / Q000008:administration & dosage / Q000633:toxicity*; D002424:Caustics / Q000008:administration & dosage / Q000633:toxicity; D004195:Disease Models, Animal; D004338:Drug Combinations; D006388:Hemagglutinins / Q000097:blood / Q000276:immunology*; D007111:Immunity, Cellular / Q000187:drug effects*; D007165:Immunosuppression Therapy / Q000379:methods*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011192:Potassium Dichromate / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000187:drug effects / Q000276:immunology* / Q000473:pathology
D002424:Caustics; D004338:Drug Combinations; D006388:Hemagglutinins; D001554:Benzene; D011192:Potassium Dichromate