Integrin proteomes reveal a new guide for cell motility.
Integrin transmembrane receptors orchestrate signaling cascades by recruiting cytoskeletal linker proteins and enzymes to sites of cell adhesion. A proteomics-based view of such integrin-associated signaling networks is now available. Besides the usual suspects, the interactomes contain several proteins that were not previously connected to integrins. One of these, regulator of chromosome condensation-2 (RCC2), represents an unexpected molecular connection between integrins and the cell-migration machinery.
Danen
Erik H J
EH
Leiden Amsterdam Center for Drug Research, Leiden University, Netherlands. e.danen@lacdr.leidenuniv.nl
D000089982:ADP-Ribosylation Factor 6; D020727:ADP-Ribosylation Factors / Q000502:physiology; D000818:Animals; D002448:Cell Adhesion / Q000502:physiology; D002465:Cell Movement / Q000502:physiology*; D002868:Chromosomal Proteins, Non-Histone / Q000502:physiology; D020662:Guanine Nucleotide Exchange Factors / Q000502:physiology; D006801:Humans; D016023:Integrins / Q000502:physiology*; D008954:Models, Biological; D020543:Proteome; D015398:Signal Transduction / Q000502:physiology*; D020830:rac1 GTP-Binding Protein / Q000502:physiology
D000089982:ADP-Ribosylation Factor 6; D002868:Chromosomal Proteins, Non-Histone; D020662:Guanine Nucleotide Exchange Factors; D016023:Integrins; D020543:Proteome; C107953:RAC1 protein, human; C477650:RCC2 protein, human; D020727:ADP-Ribosylation Factors; D020830:rac1 GTP-Binding Protein