Cytotoxic acacic acid glycosides from the roots of Albizia coriaria.
Two new oleanane-type saponins, coriariosides A (1) and B (2), along with a known saponin, gummiferaoside C (3), were isolated from the roots of Albizia coriaria. Their structures were established by extensive analysis of 1D and 2D NMR experiments (COSY, ROESY, TOCSY, HSQC, and HMBC) and mass spectrometry. Compounds 1 and 3 when tested for cytotoxicity against two colorectal human cancer cells showed activity against the HCT 116 (IC50 4.2 microM for 1 and 2.7 microM for 3) and HT-29 (IC50 6.7 microM for 1 and 7.9 microM for 3) cell lines.
Laboratoire de Pharmacognosie, UMIB, EA 3660, Faculté de Pharmacie, Université de Bourgogne, 7 Boulevard Jeanne D'Arc, BP 87900, 21079 Dijon Cedex, France.
Olivier Placide
OP
Noté
Anne-Claire
AC
Mitaine-Offer
Tomofumi
T
Miyamoto
Thomas
T
Paululat
Jean-François
JF
Mirjolet
Olivier
O
Duchamp
Dieudonné Emmanuel
DE
Pegnyemb
Marie-Aleth
MA
Lacaille-Dubois
D031289:Albizzia / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002163:Cameroon; D004354:Drug Screening Assays, Antitumor; D045325:HCT116 Cells; D019073:HT29 Cells; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification
D000972:Antineoplastic Agents, Phytogenic; D012503:Saponins; D014315:Triterpenes; C545037:coriarioside A; C545038:coriarioside B; C519243:gummiferaoside C; C413246:oleanane; D009828:Oleanolic Acid