Atypical chest pain: evidence of intercostobrachial nerve sensitization in Complex Regional Pain Syndrome.
BACKGROUND
Atypical chest pain is a common complaint among Complex Regional Pain Syndrome (CRPS) patients with brachial plexus involvement. Anatomically, the intercostobrachial nerve (ICBN) is connected to the brachial plexus and innervates the axilla, medial arm and anterior chest wall. By connecting to the brachial plexus, the ICBN could become sensitized by CRPS spread and become a source of atypical chest pain.


OBJECTIVE
To evaluate the sensitivity of chest areas in CRPS patients and normal controls.


METHODS
Prospective investigation of pressure algometry in chest areas to determine chest wall sensitivity.


METHODS
CRPS patients and normal controls volunteered to participate in our study. Each individual was examined to meet inclusion criteria. Patients' report of chest pain history was collected from every participant. Pressure algometry was used to measure pressure sensitivity in the axilla, anterior axillary line second intercostal space, mid-clavicular third rib, mid-clavicular tenth rib, and midsternal. Each of these measurements were compared to an intra-participant abdominal measure to control for an individuals generalized sensitivity. The ratios of chest wall sensitivities were compared between CRPS patients and normal controls.


RESULTS
A history of chest pain was reported by a majority (94%) of CRPS patients and a minority (19%) of normal controls. CRPS patients reported lifting their arm as a major initiating factor for chest pain. To pressure algometry, the ratios of CRPS patients were significantly greater than control subjects (p< 0.02 throughout), indicating increased chest wall sensitivity.


CONCLUSIONS
This study is limited by the relatively small number of patients (n=35) and controls (n=21) used.


CONCLUSIONS
The results of this study support the idea that chest pain is greater in CRPS patients than normal controls. The ICBN could be the source of this sensitization by CRPS spread from the brachial plexus.
Drexel University College of Medicine, Philadelphia, PA 19102-1192, USA.
Jennifer W
JW
Rasmussen
John R
JR
Grothusen
Andrea L
AL
Rosso
Robert J
RJ
Schwartzman
D000328:Adult; D001132:Arm / Q000294:innervation / Q000503:physiopathology; D001917:Brachial Plexus / Q000033:anatomy & histology / Q000503:physiopathology; D020516:Brachial Plexus Neuropathies / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D002637:Chest Pain / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D020918:Complex Regional Pain Syndromes / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007367:Intercostal Nerves / Q000033:anatomy & histology / Q000293:injuries / Q000503:physiopathology*; D008297:Male; D016462:Mammaplasty / Q000009:adverse effects; D008875:Middle Aged; D009619:Nociceptors / Q000502:physiology; D010147:Pain Measurement / Q000379:methods*; D017288:Pain Threshold / Q000502:physiology; D011237:Predictive Value of Tests; D011446:Prospective Studies; D016059:Range of Motion, Articular / Q000502:physiology; D012867:Skin / Q000294:innervation / Q000503:physiopathology; D035441:Thoracic Wall / Q000294:innervation / Q000503:physiopathology