Prophylactic use of antibiotic-loaded bone cement in primary total knee replacement.
Despite significant advances in intraoperative antimicrobial procedures, deep infection remains the most devastating complication following total joint arthroplasty. Clinical studies' results and safety profile of antibiotic-loaded bone cement are discussed in this review. Antibiotic bone cement prophylaxis is a safe and effective strategy in reducing the risk of deep infection following primary total joint arthroplasty.
Dipartimento di Scienze Medico-Chirurgiche, Università degli Studi di Milano, Policlinico San Donato IRCCS, Via Morandi 30, San Donato Milanese, 20097, Milan, Italy. pietro.randelli@tin.it
Pietro
P
Randelli
Francesco R
FR
Evola
Paolo
P
Cabitza
Luca
L
Polli
Matteo
M
Denti
Luca
L
Vaienti
D019072:Antibiotic Prophylaxis; D019645:Arthroplasty, Replacement, Knee; D001843:Bone Cements / Q000737:chemistry / Q000627:therapeutic use*; D004337:Drug Carriers / Q000627:therapeutic use; D005060:Europe; D006801:Humans; D016459:Prosthesis-Related Infections / Q000517:prevention & control*
D001843:Bone Cements; D004337:Drug Carriers