Role of p38MAPK in beta(2)AR-induced cardiomyopathy: at the heart of the matter?
Peter PS, Brady JE, Yan L et al.: Inhibition of p38alpha MAPK rescues cardiomyopathy induced by overexpressed beta(2)-adrenergic receptor, but not beta(1)-adrenergic receptor. J. Clin. Invest. 117(5), 1335-1343 (2007). The role of p38MAPK in the progression of heart failure is controversial. In the reference paper, Peter and colleagues demonstrated that p38MAPK plays an important role in the progression of heart failure in transgenic mice over-expressing the beta(2) adrenergic receptor. The authors show that p38MAPK is involved in apoptosis, fibrosis and decreased left ventricle fractional shortening in mice overexpressing beta(2) adrenergic receptor but not beta(1) adrenergic receptor. These results showed that beta(1) and beta(2) adrenergic receptors induce cardiomyopathies through different signaling pathways, and suggest an important role for p38MAPK in the development of cardiac disease.
University of Colorado Denver & Health Sciences Center, 4200 E Ninth Ave, Denver, CO 80262, USA. kika.sucharov@uchsc.edu
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