Biobehavioral factors in chemotherapy-induced nausea and vomiting.
Although emesis can be considered a reflex to clear toxins from the body and involves mostly lower brain structures, nausea's purpose appears to be a warning signal to the individual to not engage in behaviors that he or she was doing at the time. As such, it involves the functioning of cognition and memory from higher developed neural structures. Given this, it should not be surprising that biobehavioral factors are important in predicting and controlling nausea. This article reviews the individual characteristics that are clinically useful in predicting which patients will have an increased probability of experiencing nausea or emesis during chemotherapy treatment, and also briefly review psychologic and biobehavioral treatments that can be useful in managing chemotherapy-related nausea.
Cancer Control Program, James P. Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York 14642, USA. Joseph_Roscoe@urmc.rochester.edu
Joseph A
JA
Roscoe
Gary R
GR
Morrow
Jane T
JT
Hickok
Karen M
KM
Mustian
Abhay R
AR
Shelke
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D001519:Behavior / Q000502:physiology*; D001521:Behavior Therapy / Q000379:methods; D006801:Humans; D009325:Nausea / Q000209:etiology* / Q000523:psychology; D009369:Neoplasms / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology / Q000523:psychology; D017060:Patient Satisfaction; D010465:Perception / Q000502:physiology; D058831:Serotonin 5-HT3 Receptor Antagonists; D014839:Vomiting / Q000209:etiology* / Q000523:psychology
D058831:Serotonin 5-HT3 Receptor Antagonists