Highly enantioselective alkenylation of glyoxylate with vinylsilane catalyzed by chiral dicationic palladium(II) complexes.
Chiral dicationic palladium complex-catalyzed vinylation and dienylation of glyoxylate with vinylsilanes and dienylsilanes to produce highly optical active allylic alcohols has been achieved. The advantages of this reaction are that the chiral palladium catalyst is readily employed and that vinylsilanes as nucleophiles are easily synthesized, storable, and air- and moisture-stable.
Department of Applied Chemistry, Tokyo Institute of Technology, Tokyo 152-8552, Japan.
Kohsuke
K
Aikawa
Yuta
Y
Hioki
Koichi
K
Mikami
D000498:Allyl Compounds / Q000737:chemistry; D002384:Catalysis; D004355:Drug Stability; D006038:Glyoxylates / Q000737:chemistry*; D010165:Palladium; D012821:Silanes / Q000737:chemistry*; D013237:Stereoisomerism; D014753:Vinyl Compounds / Q000737:chemistry*
D000498:Allyl Compounds; D006038:Glyoxylates; D012821:Silanes; D014753:Vinyl Compounds; C476909:vinylsilane; D010165:Palladium; C031150:glyoxylic acid