Possible olanzapine-induced hepatotoxicity in a young Chinese patient.
We present a case of a 17-year-old man with first-episode schizophrenia who developed olanzapine-induced hepatitis, cholestasis, and splenomegaly, all of which were reversed after ceasing olanzapine. Clinicians prescribing olanzapine should be aware of this possible hepatotoxicity. Patient education, vigilance from clinicians, and careful clinical examination can help detect this complication early.
Lui
S Y
SY
Castle Peak Hospital, Tuen Mun, Hong Kong. simonsylui@yahoo.com.hk
Tso
Steve
S
Lam
M
M
Cheung
Eric F C
EF
D000293:Adolescent; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001569:Benzodiazepines / Q000009:adverse effects* / Q000627:therapeutic use; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D002681:China; D002779:Cholestasis / Q000139:chemically induced; D006801:Humans; D008297:Male; D000077152:Olanzapine; D012559:Schizophrenia / Q000188:drug therapy; D013163:Splenomegaly / Q000139:chemically induced
D014150:Antipsychotic Agents; D001569:Benzodiazepines; D000077152:Olanzapine