Landmarks in the understanding and treatment of reflux disease.
The last 50 years have seen a transformation in the understanding and treatment of reflux disease. The development and wide use of flexible endoscopy and progressively more sophisticated approaches to measurement of pathophysiological factors have been major drivers of advances. The recognition and progressive elucidation of the mechanical events that comprise the transient lower esophageal sphincter relaxation and how they lead to reflux provide a novel and firm foundation for tailoring therapies that act directly to reduce occurrence of reflux episodes, either surgically or pharmacologically. Novel GABA(B) agonist drugs have been shown to inhibit transient relaxations and are currently being evaluated in clinical trials on patients with reflux disease. Better understanding has extended to recognition of the extraordinarily high prevalence of reflux disease and of the ability of proton pump inhibitor drugs to deliver major benefits to a high proportion of patients with reflux disease. The life of the Gastroenterological Society of Australia has spanned the period of these major advances. A large number of the members of the Society and their associates have contributed substantially to these advances.
Department of Gastroenterology & Hepatology, Royal Adelaide Hospital & University of Adelaide, Adelaide, South Australia, Australia. john.dent@health.sa.gov.au
John
J
Dent
D001315:Australia; D016099:Endoscopy, Gastrointestinal / Q000266:history; D049630:Esophageal Sphincter, Lower / Q000503:physiopathology; D018755:GABA Agonists / Q000266:history; D005764:Gastroesophageal Reflux / Q000175:diagnosis / Q000266:history* / Q000503:physiopathology / Q000628:therapy; D005765:Gastrointestinal Agents / Q000266:history* / Q000627:therapeutic use; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D011237:Predictive Value of Tests; D054328:Proton Pump Inhibitors / Q000266:history; D012720:Severity of Illness Index; D012955:Societies, Medical / Q000266:history; D016896:Treatment Outcome
D018755:GABA Agonists; D005765:Gastrointestinal Agents; D054328:Proton Pump Inhibitors