[Combined effects of benzene and chromium on navigation learning and long-term spatial memory in rats].
The impact of long-term intake of drinking water containing the high level of chromium and benzene or their mixture on navigation learning and long-term spatial memory was studied in a Morris water maze. The chronic neurotoxic effect of benzene was characterized by worse long-term memory, which upon its exposure in combination with chromium remained unchanged and failed to block the realization of a positive effect of chromium on the mechanism of navigation learning.
V V
VV
Tikhonov
E V
EV
Ermolina
I V
IV
Miroshnichenko
D000284:Administration, Oral; D000818:Animals; D001554:Benzene / Q000008:administration & dosage / Q000633:toxicity*; D002857:Chromium / Q000008:administration & dosage / Q000633:toxicity*; D004338:Drug Combinations; D005500:Follow-Up Studies; D007858:Learning / Q000187:drug effects* / Q000502:physiology; D007859:Learning Disabilities / Q000139:chemically induced / Q000523:psychology*; D008297:Male; D008568:Memory / Q000187:drug effects* / Q000502:physiology; D008569:Memory Disorders / Q000139:chemically induced / Q000523:psychology*; D051381:Rats; D017208:Rats, Wistar; D013550:Swimming / Q000523:psychology; D013997:Time Factors; D014131:Trace Elements / Q000008:administration & dosage / Q000633:toxicity
D004338:Drug Combinations; D014131:Trace Elements; D002857:Chromium; D001554:Benzene