Functional 5-HT1a receptor polymorphism selectively modulates error-specific subprocesses of performance monitoring.
Our study investigates the dependence of response monitoring and error detection on genetic influences modulating the serotonergic system. This was done using the event-related potentials (ERPs) after error (Ne/ERN) and correct trials (Nc/CRN). To induce a sufficient amount of errors, a standard flanker task was used. The subjects (N = 94) were genotyped for the functional 5-HT1A C(-1019)G polymorphism. The results show that the 5-HT1A C(-1019)G polymorphism specifically modulates error detection. Neurophysiological modulations on error detection were paralleled by a similar modulation of response slowing after an error, reflecting the behavioral adaptation. The 5-HT1A -1019 CC genotype group showed a larger Ne and stronger posterror slowing than the CG and GG genotype groups. More general processes of performance monitoring, as reflected in the Nc/CRN, were not affected. The finding that error-specific processes, but not general response monitoring processes, are modulated by the 5-HT1A C(-1019)G polymorphism is underlined by a wavelet analysis. In summary, the results suggest a specific effect of the 5-HT1A C(-1019)G polymorphism on error monitoring, as reflected in the Ne, and suggest a neurobiological dissociation between processes of error monitoring and general response monitoring at the level of the serotonin 1A receptor system.
Beste
Christian
C
Department of Biopsychology, Institute for Cognitive Neuroscience, Ruhr-Universität Bochum, Germany.
Domschke
Katharina
K
Kolev
Vasil
V
Yordanova
Juliana
J
Baffa
Anna
A
Falkenstein
Michael
M
Konrad
Carsten
C
D000223:Adaptation, Psychological / Q000502:physiology; D000328:Adult; D001921:Brain / Q000502:physiology*; D004569:Electroencephalography; D005071:Evoked Potentials; D056344:Executive Function / Q000502:physiology; D030141:Feedback, Psychological / Q000502:physiology*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D011110:Polymorphism, Genetic; D011597:Psychomotor Performance / Q000502:physiology*; D011930:Reaction Time; D044282:Receptor, Serotonin, 5-HT1A / Q000235:genetics* / Q000378:metabolism*; D017422:Sequence Analysis, DNA; D044465:White People / Q000235:genetics
D044282:Receptor, Serotonin, 5-HT1A