Detecting vascular biosignatures with a colloidal, radio-opaque polymeric nanoparticle.
A synthetic methodology for developing a polymeric nanoparticle for targeted computed tomographic (CT) imaging is revealed in this manuscript. The work describes a new class of soft type, vascularly constrained, stable colloidal radio-opaque metal-entrapped polymeric nanoparticle using organically soluble radio-opaque elements encapsulated by synthetic amphiphile. This agent offers several-fold CT signal enhancement in vitro and in vivo demonstrating detection sensitivity reaching to the low nanomolar particulate concentration range.
C-TRAIN and Division of Cardiology, Washington University School of Medicine, 4320 Forest Park Avenue, Saint Louis, Missouri 63108, USA. dipanjan@wustl.edu
Dipanjan
D
Pan
Todd A
TA
Williams
Angana
A
Senpan
John S
JS
Allen
Mike J
MJ
Scott
Patrick J
PJ
Gaffney
Samuel A
SA
Wickline
Gregory M
GM
Lanza
D000818:Animals; D003102:Colloids; D006207:Half-Life; D053768:Metal Nanoparticles / Q000032:analysis / Q000737:chemistry* / Q000648:ultrastructure; D018625:Microscopy, Atomic Force; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D015394:Molecular Structure; D011108:Polymers / Q000737:chemistry*; D051381:Rats; D014057:Tomography, X-Ray Computed
D003102:Colloids; D011108:Polymers