In a study for acne vulgaris, sequence-based HLA typing showed a novel DPB1 allele, DPB1*2402.
In this paper, we characterize the novel human leucocyte antigen (HLA)-DPB1*2402 allele that we found in a patient suffering from acne vulgaris. In comparison to the closest related allele DPB1*0401, HLA-DPB1*2402 has a single nucleotide exchange at position 115 (202), T replaces G. In consequence, codon 39 (68) TAC encodes for tyrosine in the novel allele instead of aspartic acid 39 (68) GAC in DPB1*0401.
Labor für Immungenetik, University Munich, Germany. klaus.witter@med.unimuenchen.de
K
K
Witter
E
E
Kirchner
C
C
Borelli
G
G
Messer
T
T
Albert
R
R
Zahn
T
T
Kauke
D000152:Acne Vulgaris / Q000097:blood / Q000235:genetics*; D000483:Alleles; D001483:Base Sequence; D006682:HLA-DP Antigens / Q000097:blood / Q000235:genetics*; D059868:HLA-DP beta-Chains; D006650:Histocompatibility Testing; D006801:Humans; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D017422:Sequence Analysis, DNA; D012689:Sequence Homology, Nucleic Acid
D006682:HLA-DP Antigens; D059868:HLA-DP beta-Chains; C071170:HLA-DPB1 antigen