[Value of spiral CT plus endoscopic ultrasonography (EUS) and spiral CT plus PET-CT in the preoperative assessment of gastric cancer invasion to the pancreas].
OBJECTIVE
To evaluate the value of EUS and PET-CT in combination with spiral CT in preoperative assessment of gastric cancer invasion to the pancreas.


METHODS
Sixty advanced gastric cancer patients with suspected pancreatic invasion detected by spiral CT were selected in this study. All the 60 cases were then examined by EUS and 14 of them by PET-CT. The results were compared and evaluated with the findings during surgical operation and pathological results.


RESULTS
The rate of correct preoperative diagnosis of pancreatic invasion by spiral CT in advanced gastric cancer patients was 63.3%, with an overdiagnosis rate of 36.7%. The diagnostic accuracy was increased to 87.8% and overdiagnosis reduced to 7.3%, when combined with EUS. There was a significant difference in diagnostic accuracy between spiral CT alone and spiral CT combined with EUS (P<0.01), but no significant difference between spiral CT alone and spiral CT combined with PET-CT (P>0.05). Spiral CT-EUS was more valuable in assessment of tumor location and invasion than PET-CT (P<0.01).


CONCLUSIONS
The accuracy of spiral CT alone in the preoperative assessment of advanced gastric cancer with invasion to the pancreas is not high enough yet at present. Spiral CT combined with EUS can provide more accurate information on the tumor location, invasion site and extent of gastric cancer invasion to the pancreas, and reduce the overstaging rate caused by spiral CT alone. However, spiral CT combined with PET-CT does not show such improvement significantly.
Department of Gastrointestinopancreatic Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China.
Wu
W
Song
Yu-long
YL
He
Chang-hua
CH
Zhang
Shi-rong
SR
Cai
Xue-fu
XF
Zhou
Jian-jun
JJ
Peng
Wen-hua
WH
Zhan
D000230:Adenocarcinoma / Q000175:diagnosis* / Q000473:pathology; D002288:Adenocarcinoma, Mucinous / Q000175:diagnosis / Q000473:pathology; D000368:Aged; D018279:Carcinoma, Signet Ring Cell / Q000175:diagnosis / Q000473:pathology; D019160:Endosonography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D010179:Pancreas / Q000473:pathology*; D049268:Positron-Emission Tomography; D057234:Preoperative Period; D011446:Prospective Studies; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000473:pathology; D036542:Tomography, Spiral Computed