Association between prepregnancy body mass index and congenital heart defects.
OBJECTIVE
The purpose of this study was to examine associations between prepregnancy body mass index (BMI) and congenital heart defects (CHDs).


METHODS
These analyses included case infants with CHDs (n = 6440) and liveborn control infants without birth defects (n = 5673) enrolled in the National Birth Defects Prevention Study (1997-2004).


RESULTS
Adjusted odds ratios for all CHDs combined were 1.16 (95% confidence interval [CI], 1.05-1.29), 1.15 (95% CI, 1.00-1.32), and 1.31 (95% CI, 1.11-1.56) for overweight status, moderate obesity, and severe obesity, respectively. Phenotypes associated with elevated BMI (> or =25.0 kg/m(2)) were conotruncal defects (tetralogy of Fallot), total anomalous pulmonary venous return, hypoplastic left heart syndrome, right ventricular outflow tract (RVOT) defects (pulmonary valve stenosis), and septal defects (secundum atrial septal defect).


CONCLUSIONS
These results corroborated those of previous studies and suggested new associations between obesity and conotruncal defects and RVOT defects.
National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Suzanne M
SM
Gilboa
Adolfo
A
Correa
Lorenzo D
LD
Botto
Sonja A
SA
Rasmussen
D Kim
DK
Waller
Charlotte A
CA
Hobbs
Mario A
MA
Cleves
Tiffany J
TJ
Riehle-Colarusso
D015992:Body Mass Index; D016640:Diabetes, Gestational / Q000453:epidemiology; D005260:Female; D006330:Heart Defects, Congenital / Q000453:epidemiology*; D006801:Humans; D009765:Obesity / Q000453:epidemiology*; D016017:Odds Ratio; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology*; D012307:Risk Factors