Colorimetric detection of thiols using a chromene molecule.
A new thiol-containing colorimetric probe has been developed by using a chromene derivative, 7-nitro-2,3-dihydro-1H-cyclopenta[b]chromen-1-one (1). The molecule exhibited high selectivity and sensitivity for detecting thiol species as cysteine, homocysteine, and glutathione in aqueous solution through a rapid visual color change from colorless to yellow.
Research Institute of Applied Chemistry, Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, Taiyuan, 030006, China.
Fang-Jun
FJ
Huo
Yuan-Qiang
YQ
Sun
Jing
J
Su
Jian-Bin
JB
Chao
Hai-Juan
HJ
Zhi
Cai-Xia
CX
Yin
D001578:Benzopyrans / Q000138:chemical synthesis / Q000737:chemistry*; D003124:Colorimetry / Q000379:methods; D005456:Fluorescent Dyes / Q000737:chemistry*; D015394:Molecular Structure; D013438:Sulfhydryl Compounds / Q000032:analysis*
C545766:7-nitro-2,3-dihydro-1H-cyclopenta(b)chromen-1-one; D001578:Benzopyrans; D005456:Fluorescent Dyes; D013438:Sulfhydryl Compounds