Future directions in antiarrhythmic drug therapy for atrial fibrillation.
Atrial fibrillation is the most commonly sustained cardiac arrhythmia. Drugs currently approved by the US FDA for the treatment of this arrhythmia are imperfect owing to either side effects or limited efficacy. Drug development strategies have focused on two areas: the modification of existing agents--such as Class III drugs aimed at improving their safety and efficacy profile--and targeting newly postulated mechanisms of atrial fibrillation. In this article, we review new drugs currently in development and promising drug strategies for atrial fibrillation prevention and treatment.
Musco
Simone
S
Division of Cardiovascular Diseases, Main Line Heart Center, 556 Medical Science Building, 100 Lancaster Avenue, Wynnewood, PA 19096, USA. muscos@mlhs.org
Seltzer
Jonathan
J
Kowey
Peter R
PR