Polymorphonuclear neutrophils and T lymphocytes: strange bedfellows or brothers in arms?
Polymorphonuclear neutrophils (PMN) are linked invariably to the innate immune response, particularly to the defence against bacterial infection. T lymphocytes are studied mainly in virus infections, the defence against tumours, the development and progression of chronic inflammatory processes, in autoimmune phenomena and in materno-fetal tolerance. There is, however, increasing evidence for communication and interactions between PMN and T cells that we discuss here in the context of different physiological and pathological conditions, including acute and chronic inflammatory disease, defence against tumours, and maintenance of pregnancy.
Department of Immunology, Faculty of Medicine, Imperial College London, London W2 1PG, UK.
Ingrid
I
Müller
Markus
M
Munder
Pascale
P
Kropf
Gertrud Maria
GM
Hänsch
D000818:Animals; D015551:Autoimmunity / Q000276:immunology; D001424:Bacterial Infections / Q000276:immunology* / Q000382:microbiology; D002450:Cell Communication / Q000276:immunology; D016207:Cytokines / Q000276:immunology* / Q000378:metabolism; D005260:Female; D006801:Humans; D007110:Immunity, Active; D007113:Immunity, Innate; D007249:Inflammation / Q000276:immunology* / Q000378:metabolism / Q000382:microbiology; D009369:Neoplasms / Q000276:immunology / Q000378:metabolism; D009504:Neutrophils / Q000276:immunology* / Q000382:microbiology; D011247:Pregnancy; D013601:T-Lymphocytes / Q000276:immunology* / Q000382:microbiology
D016207:Cytokines