Superior biocompatibility and osteogenic efficacy of micro-arc oxidation-treated titanium implants in the canine mandible.
The aim of this paper is to test implantation outcomes and osteogenic efficacy of plasma micro-arc oxidation (MAO)-treated titanium implants in dogs. Thirty-six pure titanium implants (18 MAO-treated, 18 untreated) were inserted into the mandibles of nine adult beagles and allowed to heal under non-weight-bearing conditions. Implant stability and interface characteristics were evaluated at 4, 8 and 12 weeks post-implantation. Methods included scanning electron microscopy, mechanical testing, histological analysis and computer-quantified tissue morphology. Osseointegration was achieved in both groups, but occurred earlier and more extensively in the MAO group. Areas of direct bone/implant contact were approximately nine times higher in the MAO group than in the control group at 12 weeks (65.85% versus 7.37%, respectively; p < 0.01). Bone-implant shear strength in the MAO group (71.4, 147.2 and 266.3 MPa at weeks 4, 8 and 12, respectively) was higher than in the control group (4.3, 7.1, and 11.8 MPa at weeks 4, 8 and 12, respectively), at all assessments (all, p < 0.01). MAO treatment of titanium implants promotes more rapid formation of new bone, and increases bone-implant shear strength compared to untreated titanium implants.
Ran
Wei
W
Department of Oral and Maxillofacial Surgery, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, People's Republic of China. ranweigd@gmail.com
Tian
Zhi-Hui
ZH
Guo
Bing
B
Shu
Da-Long
DL
Nan
Kai-Hui
KH
Wang
Ying-Jun
YJ
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D015921:Dental Implants; D003764:Dental Materials / Q000737:chemistry*; D017267:Dental Prosthesis Design; D004285:Dogs; D006358:Hot Temperature; D008334:Mandible / Q000166:cytology / Q000502:physiology* / Q000601:surgery*; D010012:Osteogenesis / Q000187:drug effects / Q000502:physiology*; D010084:Oxidation-Reduction; D014025:Titanium / Q000737:chemistry*
D001672:Biocompatible Materials; D015921:Dental Implants; D003764:Dental Materials; D014025:Titanium