[Receptor caspase-dependent and caspase-independent ways of human lymphocytes apoptosis induced by UV-radiation].
Changes of a structural condition of DNA, expression level of the membrane Fas-receptor and of functional activity of the human lymphocytes caspase-3 in dynamics of apoptosis development, induced by influence of UV-light (240-390 nm) in doses 151, 1510 and 3020 J/m2 are studied. It is established, that the UV-irradiation of lymphocytes in doses of 151 and 1510 J/m2 causes realisation of receptor caspase-dependent apoptosis way. The assumption about switching possibility of receptor caspase-dependent way apoptosis on receptor caspase-independent way at increase of a dose of UV-light to 3020 J/m2 is made.
V G
VG
Artiukhov
M A
MA
Nakvasina
M S
MS
Trubitsyna
I Iu
IIu
Popova
I Iu
IIu
Iskusnykh
D017209:Apoptosis; D053148:Caspase 3 / Q000378:metabolism; D020169:Caspases / Q000378:metabolism*; D002467:Cell Nucleus / Q000378:metabolism; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D008214:Lymphocytes / Q000201:enzymology / Q000502:physiology / Q000528:radiation effects*; D014466:Ultraviolet Rays; D019014:fas Receptor / Q000502:physiology*
D019014:fas Receptor; D053148:Caspase 3; D020169:Caspases