Regioselective alkynylation followed by Suzuki coupling of 2,4-dichloroquinoline: synthesis of 2-alkynyl-4-arylquinolines.
A two step synthesis of 2-alkynyl-4-arylquinolines has been accomplished via Pd/C-mediated regioselective C-2 alkynylation of 2,4-dichloroquinoline in water followed by Suzuki coupling at C-4 of the resulting 4-chloro derivative.
Dr. Reddy's Laboratories Limited, Bollaram Road, Miyapur, Hyderabad 500049, Andhra Pradesh, India.
Ellanki Amarender
EA
Reddy
Aminul
A
Islam
K
K
Mukkanti
Venkanna
V
Bandameedi
Dipal Ranjan
DR
Bhowmik
Manojit
M
Pal