Primary lymphoma of the colon.
Primary lymphoma of the colon is a rare tumor of the gastrointestinal (GI) tract and comprises only 0.2-1.2% of all colonic malignancies. The most common variety of colonic lymphoma is non-Hodgkin's lymphoma (NHL). The GI tract is the most frequently involved site, accounting for 30-40% of all extra nodal lymphomas, approximately 4-20% of which are NHL. The stomach is the most common location of GI lymphomas, followed by the small intestine. Early diagnosis may prevent intestinal perforation; however, the diagnosis is often delayed in most cases. Therapeutic approaches described in two subsets include: Radical tumor resection (hemicolectomy) plus multi-agent chemotherapy (polychemotherapy) in early stage patients, biopsy plus multidrug chemotherapy in advanced stage patients. Radiotherapy is reserved for specific cases; surgery alone can be considered as an adequate treatment for patients with low-grade NHL disease that does not infiltrate beyond the sub mucosa. Although resection plays an important role in the local control of the disease and in preventing bleeding and/or perforation, it rarely eradicates the lymphoma by itself. Those with limited stage disease may enjoy prolonged survival when treated with aggressive chemotherapy.
Tauro
Leo F
LF
Department of General Surgery, Fr. Muller Medical College Hospital, Kankanady, Mangalore, India. drlftauro@rediffmail.com
Furtado
Harold W
HW
Aithala
Panambur S
PS
D'Souza
Clement S
CS
George
Celine
C
Vishnumoorthy
Santhrupth H
SH
D003110:Colonic Neoplasms / Q000473:pathology* / Q000601:surgery*; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000473:pathology* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging