Vitamin E exhibits bone anabolic actions in normal male rats.
Recently, vitamin E has been found to promote the bone structure of nicotine-treated rats well above their baseline values, thus suggesting that vitamin E may have some anabolic action. A bone anabolic agent acts by improving the bone structure leading to stronger bone. To assess the possible anabolic action vitamin E on bone, we supplemented alpha-tocopherol (ATF) or gamma-tocotrienol (GTT) at 60 mg/kg or vehicle [normal control (NC) group] for 4 months to normal male rats and measured their bone structure and biomechanical properties. Histomorphometric analysis revealed that vitamin E-supplemented rats have better trabecular volume, thickness, number, and separation than rats receiving vehicle only. For the first time we reported that GTT improves all the parameters of bone biomechanical strength, while ATF only improved some of the parameters compared to the NC group. Vitamin E supplementation, especially with the gamma isomer, improves bone structure, which contributed to stronger bone. Therefore, vitamin E has the potential to be used as an anabolic agent to treat osteoporosis or as bone supplements for young adults to prevent osteoporosis in later years.
Department of Pharmacology, Faculty of Medicine UKM, Universiti Kebangsaan Malaysia, Jln Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia.
Ahmad Nazrun
AN
Shuid
Zulfadli
Z
Mehat
Norazlina
N
Mohamed
Norliza
N
Muhammad
Ima Nirwana
IN
Soelaiman
D045930:Anabolic Agents / Q000008:administration & dosage*; D000818:Animals; D001696:Biomechanical Phenomena; D015519:Bone Density / Q000187:drug effects*; D050071:Bone Density Conservation Agents / Q000008:administration & dosage; D001842:Bone and Bones / Q000033:anatomy & histology / Q000737:chemistry / Q000187:drug effects / Q000502:physiology*; D002839:Chromans / Q000008:administration & dosage; D019587:Dietary Supplements; D005269:Femur / Q000033:anatomy & histology / Q000737:chemistry; D008297:Male; D009929:Organ Size; D010024:Osteoporosis / Q000517:prevention & control; D051381:Rats; D017207:Rats, Sprague-Dawley; D013314:Stress, Mechanical; D014810:Vitamin E / Q000008:administration & dosage* / Q000031:analogs & derivatives / Q000502:physiology; D024502:alpha-Tocopherol / Q000008:administration & dosage
D045930:Anabolic Agents; D050071:Bone Density Conservation Agents; D002839:Chromans; D014810:Vitamin E; C013649:plastochromanol 8; D024502:alpha-Tocopherol