Prospective comparison of tuberculin skin test and QuantiFERON-TB Gold In-Tube assay for the detection of latent tuberculosis infection among healthcare workers in a low-incidence setting.
We compared the results of the tuberculin skin test with the results of the QuantiFERON-TB Gold In-Tube (QFT-GIT) assay among 182 low-risk healthcare workers. Overall agreement and specificity were high, but the tests did not agree on positive results. Only 2 of 5 positive QFT-GIT assay results could be confirmed with repeat analyses. Indeterminate results were associated with potential immunosuppression.
Cummings
Kristin J
KJ
Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505, USA. cvx5@cdc.gov
Smith
Tamara S
TS
Shogren
Elizabeth S
ES
Khakoo
Rashida
R
Nanda
Sharmilarani
S
Bunner
Lana
L
Smithmyer
Ann
A
Soccorsi
Darlene
D
Kashon
Michael L
ML
Mazurek
Gerald H
GH
Friedman
Lloyd N
LN
Weissman
David N
DN
D006282:Health Personnel; D006801:Humans; D015994:Incidence; D007371:Interferon-gamma / Q000097:blood*; D055985:Latent Tuberculosis / Q000175:diagnosis* / Q000453:epidemiology / Q000382:microbiology; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D011933:Reagent Kits, Diagnostic; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014374:Tuberculin Test / Q000379:methods*
D011933:Reagent Kits, Diagnostic; D007371:Interferon-gamma