The influence of perceptual and semantic categorization on inhibitory processing as measured by the N2-P3 response.
In daily activities, humans must attend and respond to a range of important items and inhibit and not respond to unimportant distractions. Our current understanding of these processes is largely based on perceptually simple stimuli. This study investigates the interaction of conceptual-semantic categorization and inhibitory processing using Event Related Potentials (ERPs). Participants completed three Go-NoGo tasks that increased systematically in the degree of conceptual-semantic information necessary to respond correctly (from single items to categories of objects and animals). Findings indicate that the N2 response reflects inhibitory processing but does not change significantly with task difficulty. The P3 NoGo amplitude, on the other hand, is attenuated by task difficulty. Further, the latency of the peak of the P3 NoGo response elicited by the most difficult task is significantly later than are the peaks detected during performance of the other two tasks. Thus, the level of complexity of conceptual-semantic representations influences inhibitory processing in a systematic way. This inhibition paradigm may be a key for investigating inhibitory dysfunction in patient populations.
Center for BrainHealth, University of Texas at Dallas, Dallas, TX 75235, USA. mandy.maguire@utdallas.edu
Mandy J
MJ
Maguire
Matthew R
MR
Brier
Patricia S
PS
Moore
Thomas C
TC
Ferree
Dylan
D
Ray
Stewart
S
Mostofsky
John
J
Hart
Michael A
MA
Kraut
D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D001288:Attention / Q000502:physiology; D001921:Brain / Q000502:physiology; D002755:Choice Behavior / Q000502:physiology; D003210:Concept Formation / Q000502:physiology*; D004569:Electroencephalography; D005074:Evoked Potentials, Visual / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D009433:Neural Inhibition / Q000502:physiology*; D009483:Neuropsychological Tests; D018579:Patient Selection; D010775:Photic Stimulation; D011597:Psychomotor Performance / Q000502:physiology; D011930:Reaction Time / Q000502:physiology; D012815:Signal Processing, Computer-Assisted; D014796:Visual Perception / Q000502:physiology*