Preferential enhancement of working memory in mice lacking adenosine A(2A) receptors.
There is evidence that adenosine acting at A(2A) receptors (A(2A)R) can influence striatal plasticity and cognitive functions. We examined spatial working memory in wild-type (WT) and A(2A) receptor knock-out (KO) mice using two assessments: the eight arm radial maze and a repeated trial Morris water maze (MWM) paradigm. Compared to WT littermates, A(2A)R KO mice displayed enhanced working memory as evidenced by a decrease in escape latency in trial 2 compared to trial 1 in the repeated trial MWM, and by a reduction in working memory errors in the radial arm maze. Both MWM and radial maze results indicated that this enhancement of working memory in A(2A)R KO mice was selective for this specific short-term memory. The decrease in escape latency in MWM was detected with an inter-trial interval of 15 s but not with intervals of 10 or 60 min. In the radial maze, spatial reference memory and memory retention after prolonged training (15 days but not 6 days) were not affected by the A(2A)R KO. These results demonstrate preferential improvement in spatial working memory by genetic inactivation of the A(2A)R and support a modulatory role of the A(2A)R in spatial working memory in mice.
Zhou
Sai-Jun
SJ
Department of Neurology, the First Affiliated Hospital and Research Institute of Experimental Neurobiology, Wenzhou Medical College, Wenzhou 325000, Zhejiang, PR China.
Zhu
Mei-Er
ME
Shu
Dan
D
Du
Xun-Ping
XP
Song
Xiu-Hua
XH
Wang
Xiao-Tong
XT
Zheng
Rong-Yuan
RY
Cai
Xiao-Hong
XH
Chen
Jiang-Fan
JF
He
Jin-Cai
JC
D000241:Adenosine / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry / Q000235:genetics; D018782:Maze Learning / Q000502:physiology; D008569:Memory Disorders / Q000235:genetics / Q000503:physiopathology / Q000628:therapy; D008570:Memory, Short-Term / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D009483:Neuropsychological Tests; D009949:Orientation / Q000502:physiology; D011930:Reaction Time / Q000235:genetics; D043705:Receptor, Adenosine A2A / Q000235:genetics*; D013028:Space Perception / Q000502:physiology*
D043705:Receptor, Adenosine A2A; D000241:Adenosine