Systemic inflammatory response syndrome in nonhuman primates culminating in multiple organ failure, acute lung injury, and disseminated intravascular coagulation.
The systemic inflammatory response syndrome (SIRS) is a clinicopathological manifestation of overexuberant acute-phase inflammation caused by infectious or noninfectious etiologies. The systemic release of pro-inflammatory cytokines, chemokines, and lipid and vasoactive mediators induces endothelial damage and microvascular thrombosis, potentially culminating in disseminated intravascular coagulation (DIC), acute respiratory distress syndrome (ARDS), and multiple organ dysfunction (MOD) or failure (MOF). We present five cases in the pig-tailed macaque and olive baboon where SIRS resulted in MOF, ARDS, DIC, and the Waterhouse-Friderichsen syndrome; each with gross and histological elements manifested as edema, deposition of fibrin, hemorrhage, and thrombosis. In the described cases, SIRS was the end-common pathway for multiple risk factors that parallel those documented in humans: major surgery, obstetric complications, and infection. The diagnosis of SIRS should be considered when evaluating nonhuman primate (NHP) cases of MOF manifesting with histological evidence of vascular leakage. Experimental manipulation of NHP models may be complicated by SIRS and accompanying rapid clinical decompensation. Such adverse events may compromise toxicological studies and should be avoided when possible.
University of Washington, Department of Comparative Medicine, Seattle, Washington 98195-7190, USA. rgamboa@wanprc.org
Renee R
RR
Hukkanen
H Denny
HD
Liggitt
Robert D
RD
Murnane
Charles W
CW
Frevert
D055371:Acute Lung Injury / Q000097:blood / Q000473:pathology / Q000662:veterinary*; D000818:Animals; D016207:Cytokines / Q000378:metabolism; D004211:Disseminated Intravascular Coagulation / Q000097:blood / Q000473:pathology / Q000662:veterinary*; D005260:Female; D008254:Macaca nemestrina; D008297:Male; D009102:Multiple Organ Failure / Q000097:blood / Q000473:pathology / Q000662:veterinary*; D048530:Papio anubis; D012307:Risk Factors; D018746:Systemic Inflammatory Response Syndrome / Q000097:blood / Q000473:pathology / Q000662:veterinary*
D016207:Cytokines