Transformation from committed progenitor to leukemia stem cells.
Leukemias are composed of a hierarchy of cells, only a fraction of which have stem cell-like properties and are capable of self-renewal. Mixed lineage leukemia (MLL) fusion proteins produced by translocations involving the MLL gene on chromosome 11q23 confer stem cell-like properties on committed hematopoietic progenitors. This provides an opportunity to assess changes in immunophenotype, gene expression, and epigenetic programs during the transition from a hematopoietic cell with minimal inherent self-renewal capability to cells capable of leukemic self-renewal.
Division of Hematology/Oncology, Children's Hospital, Department of Pediatric Oncology, Dana Farber Cancer Institute, and Harvard Medical School, Boston, Massachusetts 02215, USA.
Andrei V
AV
Krivtsov
Zhaohui
Z
Feng
Scott A
SA
Armstrong
D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D006412:Hematopoietic Stem Cells / Q000473:pathology*; D006657:Histones / Q000378:metabolism; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000473:pathology*; D008745:Methylation; D051379:Mice; D051788:Myeloid-Lymphoid Leukemia Protein; D014411:Neoplastic Stem Cells / Q000473:pathology*
D006657:Histones; D051788:Myeloid-Lymphoid Leukemia Protein