Adsorption of the Pt(II) anticancer drug carboplatin by mesoporous silica.
MCM-41, a mesoporous silica nanomaterial with a high surface area for adsorption of small molecules, is a potential new type of delivery vehicle for therapeutic and diagnostic agents. In this report, we show that MCM-41 adsorbs the front-line anticancer drug carboplatin, [Pt(CBDCA-O,O')(NH3)2] (CBDCA=cyclobutane-1,1-dicarboxylate; 1), which is used to treat ovarian, lung, and other types of cancer. UV/Visible difference absorption spectroscopy shows that MCM-41 adsorbs 1.8+/-0.2% of its own weight of carboplatin after a 24 h exposure to 26.9 mM drug in H2O. The pseudo-first-order rate constant for adsorption of carboplatin by MCM-41, measured using [1H,15N] heteronuclear single quantum coherence (HSQC) NMR, and 15N-labeled carboplatin is k(1)=2.92+/-2.17 x 10(-6) s(-1) at ca. 25 degrees.
Department of Chemistry, Syracuse University, 111 College Place, CST, Rm 1-014, Syracuse, New York 13244-4100, USA.
Anthony J
AJ
Di Pasqua
Silvia
S
Wallner
Deborah J
DJ
Kerwood
James C
JC
Dabrowiak
D000327:Adsorption; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D016190:Carboplatin / Q000737:chemistry* / Q000494:pharmacology; D004337:Drug Carriers; D009682:Magnetic Resonance Spectroscopy; D012822:Silicon Dioxide / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet
D000970:Antineoplastic Agents; D004337:Drug Carriers; C509968:MCM-41; D012822:Silicon Dioxide; D016190:Carboplatin