Metachronous mediastinal seminoma occurring after intracranial germinoma in an adolescent.
We report a case of a mediastinal seminoma occurring 19 months after the resolution of a pineal germinoma. A 15-year-old boy with headaches and visual changes was diagnosed with a pineal germinoma by biopsy and mildly elevated beta-human chorionic gonadatropin (beta-HCG) in serum and cerebral spinal fluid. Radiation therapy leads to the resolution of his pineal germinoma and normalization of the beta-HCG. A mediastinal seminoma (germinoma) was diagnosed nearly 2 years later because of rising serum beta-HCG. There was no evidence of recurrent central nervous system disease. The patient underwent systemic chemotherapy with the complete resolution of the mediastinal seminoma.
Division of Pediatric Hematology/Oncology, Kosair Children's Hospital, University of Louisville, KY 40202, USA. k0ayya01@louisville.edu
Kanyalakshmi
K
Ayyanar
Samuel C
SC
Blackman
Christine
C
Chordas
Lindsay
L
Frazier
Mark W
MW
Kieran
D000293:Adolescent; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood / Q000134:cerebrospinal fluid; D018237:Germinoma / Q000097:blood / Q000134:cerebrospinal fluid / Q000473:pathology / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008479:Mediastinal Neoplasms / Q000097:blood / Q000134:cerebrospinal fluid / Q000188:drug therapy* / Q000473:pathology; D016609:Neoplasms, Second Primary / Q000097:blood / Q000134:cerebrospinal fluid / Q000188:drug therapy* / Q000473:pathology; D010871:Pinealoma / Q000097:blood / Q000134:cerebrospinal fluid / Q000473:pathology / Q000532:radiotherapy*; D018239:Seminoma / Q000097:blood / Q000134:cerebrospinal fluid / Q000188:drug therapy* / Q000473:pathology; D013997:Time Factors
D018997:Chorionic Gonadotropin, beta Subunit, Human