Stratum corneum damage and ex vivo porcine skin water absorption - a pilot study.
A simple ex vivo screening technique would be of interest for mass screening of substances for potential barrier disruptive qualities. Ex vivo water absorption as a marker of skin barrier integrity was studied on pig ear skin. Skin water absorption was quantified by weighing and weight changes were found to reflect prehydration barrier damage. It is suggested that this simple model may be elaborated to provide a rapid, economical screening tool for potential skin irritants.
Duch Lynggaard
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C
Department of Dermatology, Health Sciences Faculty, University of Copenhagen, Roskilde Hospital, Roskilde, Denmark. clynggaard@dadlnet.dk
Bang Knudsen
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D
Jemec
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GB
D000818:Animals; D023421:Models, Animal; D010865:Pilot Projects; D012867:Skin / Q000378:metabolism* / Q000473:pathology; D012869:Skin Absorption; D023422:Skin Irritancy Tests / Q000379:methods; D013552:Swine; D014867:Water / Q000378:metabolism*
D014867:Water