Metastatic uterine cervical cancer originating in the lung: a case report.
We report a case of primary pulmonary adenocarcinoma which metastasized to the uterine cervix. A 69-year-old postmenopausal Japanese female was admitted to our hospital because of general fatigue and atypical genital bleeding. Four years before, she had undergone video-assisted thoracoscopic right upper lobectomy, for primary lung cancer (adenocarcinoma), stage IIIb, pT3N1M0. Gynecologic investigation showed a cauliflower-like tumor in the uterine cervix and parametrial invasion towards the bilateral pelvic wall. Metastasis of extragenital carcinoma to the cervix uteri is rare. Most such reported cases originated in the breast and gastrointestinal tract. In this case, cervical biopsy specimens were revealed to be adenocarcinomatous, similar in pathological features to the previously resected lung cancer. Immunohistochemical staining was positive for thyroid transcription factor-1 and pulmonary surfactant apoprotein A and negative for CA125 and thyroglobulin. Although rare, the respiratory tract should be considered as a possible primary site of uterine cervical metastatic carcinoma.
Kai
Kentaro
K
Department of Obstetrics and Gynecology, Oita University, Japan.
Takai
Noriyuki
N
Nasu
Kaei
K
Kira
Naoko
N
Ishii
Terukazu
T
Kashima
Kenji
K
Narahara
Hisashi
H
D000230:Adenocarcinoma / Q000188:drug therapy / Q000473:pathology / Q000556:secondary*; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001059:Apoproteins / Q000032:analysis; D018394:CA-125 Antigen / Q000032:analysis; D016190:Carboplatin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D008279:Magnetic Resonance Imaging; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy; D009687:Nuclear Proteins / Q000032:analysis; D017239:Paclitaxel / Q000008:administration & dosage; D037661:Pulmonary Surfactant-Associated Proteins / Q000032:analysis; D013954:Thyroglobulin / Q000032:analysis; D000074482:Thyroid Nuclear Factor 1; D014057:Tomography, X-Ray Computed; D014157:Transcription Factors / Q000032:analysis; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000556:secondary*
D001059:Apoproteins; D018394:CA-125 Antigen; C000614412:NKX2-1 protein, human; D009687:Nuclear Proteins; D037661:Pulmonary Surfactant-Associated Proteins; D000074482:Thyroid Nuclear Factor 1; D014157:Transcription Factors; C046616:pulmonary surfactant apoprotein; D013954:Thyroglobulin; D016190:Carboplatin; D017239:Paclitaxel