Embryonic vs. adult myogenesis: challenging the 'regeneration recapitulates development' paradigm.
A popular theory in the stem cell field is that 'regeneration recapitulates development', or that adult stem cells function similarly to embryonic ones. In a recent Nature article, Lepper et al. questioned this approach, highlighting the differences in requirements for Pax7 during myogenesis for embryonic, juvenile and adult muscle.
Department of Bioengineering, University of California, Berkeley, 174 Stanley Hall, Berkeley, CA 94720-1762, USA.
John
J
Wang
Irina
I
Conboy
D000818:Animals; D005260:Female; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D024510:Muscle Development; D018482:Muscle, Skeletal / Q000196:embryology* / Q000254:growth & development* / Q000378:metabolism / Q000502:physiology; D051763:PAX7 Transcription Factor / Q000235:genetics / Q000378:metabolism; D012038:Regeneration; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism
D051763:PAX7 Transcription Factor