Sodium and brain injury: do we know what we are doing?
There is mounting evidence, including the recent report by Maggiore and colleagues, of an association between hypernatremia and mortality in patients with traumatic brain injury. This mandates a re-evaluation of routine administration of agents such as hypertonic saline for the management of intracranial hypertension in those with traumatic brain injury.
Zygun
David A
DA
Department of Critical Care Medicine, University of Calgary, Calgary, Alberta, Canada. dzygun@ucalgary.ca
D001930:Brain Injuries / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D006955:Hypernatremia / Q000401:mortality* / Q000517:prevention & control; D019586:Intracranial Hypertension / Q000188:drug therapy; D012462:Saline Solution, Hypertonic / Q000008:administration & dosage / Q000627:therapeutic use
D012462:Saline Solution, Hypertonic