9-Amino acridines undergo reversible amine exchange reactions in water: implications on their mechanism of action in vivo.
9-Amino substituted acridines undergo a reversible amine exchange reaction in water under near-physiological conditions via an unstable hemiaminal intermediate. This thermodynamically controlled reaction may have implications in understanding the mode of action of 9-aminoacridines in vivo and in the future design of drugs based on this scaffold.
Paul
Alexis
A
ISIS Université de Strasbourg, BP 70028, 67083 Strasbourg, France.
Ladame
Sylvain
S
D000588:Amines / Q000737:chemistry*; D000609:Aminoacridines / Q000138:chemical synthesis / Q000737:chemistry*; D015195:Drug Design; D008956:Models, Chemical; D015394:Molecular Structure; D014867:Water / Q000737:chemistry
D000588:Amines; D000609:Aminoacridines; D014867:Water