[Exogenous succinate reduces vibration-induced disorders of energy metabolism in rabbit cardiomyocytes].
The aim of the paper was to study the mechanism of vibroprotective action of cuccinate on cardiomyocytes of a rabbit. The changes in functional activity of mitochondria were observed after prolong common vibration within 56 days. Cuccinate 8.4 mg/kg per os activated NAD-dependent site of cell breath and reduced hyperactivation of cuccinate-dependent breath by means of down-up mechanism. The positive energotropic effect of succinate was accompanied with retention of histomorphological architecture of the myocardium. Therefore, cuccinate defends the myocardium in chronic exposure of common vibration.
Vorob'eva
V V
VV
Shabanov
P D
PD
D000818:Animals; D004734:Energy Metabolism; D032383:Myocytes, Cardiac / Q000187:drug effects* / Q000378:metabolism; D009243:NAD / Q000378:metabolism; D010101:Oxygen Consumption / Q000502:physiology; D011817:Rabbits; D019802:Succinic Acid / Q000494:pharmacology*; D014732:Vibration / Q000009:adverse effects*
D009243:NAD; D019802:Succinic Acid