A cut above the other caspases.
In this issue of Molecular Cell, Bouchier-Hayes et al. (2009) develop a novel approach to visualizing caspase-2 activation in real time, enabling resolution of several controversies surrounding the position of this enzyme in apoptotic signaling cascades.
Andersen
Joshua L
JL
Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Box 3813, C370 LSRC, Durham, NC 27710, USA.
Kornbluth
Sally
S
D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D053477:Apoptotic Protease-Activating Factor 1 / Q000378:metabolism; D001426:Bacterial Proteins / Q000235:genetics; D015374:Biosensing Techniques; D053420:CRADD Signaling Adaptor Protein / Q000378:metabolism; D053143:Caspase 2 / Q000235:genetics / Q000378:metabolism*; D003593:Cytoplasm / Q000201:enzymology*; D004249:DNA Damage; D004268:DNA-Binding Proteins / Q000378:metabolism; D004789:Enzyme Activation; D053200:Fas-Associated Death Domain Protein / Q000378:metabolism; D018841:HSP90 Heat-Shock Proteins / Q000378:metabolism; D000076249:Heat Shock Transcription Factors; D006358:Hot Temperature; D006801:Humans; D007700:Kinetics; D008164:Luminescent Proteins / Q000235:genetics; D051379:Mice; D018613:Microscopy, Confocal; D055503:Protein Multimerization; D011993:Recombinant Fusion Proteins / Q000378:metabolism; D015398:Signal Transduction; D013312:Stress, Physiological; D014157:Transcription Factors / Q000378:metabolism; D050257:Tubulin Modulators / Q000494:pharmacology
D053477:Apoptotic Protease-Activating Factor 1; D001426:Bacterial Proteins; D053420:CRADD Signaling Adaptor Protein; C484481:Cradd protein, mouse; D004268:DNA-Binding Proteins; D053200:Fas-Associated Death Domain Protein; D018841:HSP90 Heat-Shock Proteins; C533585:HSP90AA2P protein, human; D000076249:Heat Shock Transcription Factors; C490017:Hsf1 protein, mouse; D008164:Luminescent Proteins; D011993:Recombinant Fusion Proteins; D014157:Transcription Factors; D050257:Tubulin Modulators; C054562:yellow fluorescent protein, Bacteria; D053143:Caspase 2