Synthesis and antifungal activity of 5-chloro-6-phenylpyridazin-3(2H)-one derivatives.
An effective method has been developed for the preparation under mild conditions of novel pyridazine derivatives from the easily accessible starting materials mucochloric acid and benzene. All the synthesized compounds were fully characterized and some of them displayed good antifungal activities against G. zeae, F. oxysporum and C. mandshurica in preliminary antifungal activity tests.
Key Laboratory of Green Pesticide and Agriculture Bioengineering, Ministry of Education, Research and Development Center for Fine Chemicals, Guizhou University, Guiyang 550025, China. jianwu2691@yahoo.com.cn
Jian
J
Wu
Baoan
B
Song
Hongjun
H
Chen
Pinaki
P
Bhadury
Deyu
D
Hu
D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001681:Biological Assay; D005658:Fungi / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D011724:Pyridazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D000935:Antifungal Agents; D011724:Pyridazines; C062482:pyridazine