Heteroaromatic sulfonates and phosphates as electrophiles in iron-catalyzed cross-couplings.
Employment of heteroaromatic tosylates and phosphates as suitable electrophiles in iron-catalyzed cross-coupling reactions with alkyl Grignard reagents is reported. These reactions are performed at low temperature allowing good functional group tolerance and full conversion is achieved within minutes. In addition, an aryl-aryl cross-coupling utilizing a heteroaryl sulfamate electrophile is reported.
Center for Insoluble Protein Structures (inSPIN), Department of Chemistry, Aarhus University, Langelandsgade 140, 8000 Aarhus C, Denmark.
Thomas M
TM
Gøgsig
Anders T
AT
Lindhardt
Troels
T
Skrydstrup
D000476:Alkanesulfonates / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D002712:Chlorides; D003432:Cross-Linking Reagents / Q000138:chemical synthesis* / Q000737:chemistry; D005290:Ferric Compounds / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010710:Phosphates / Q000138:chemical synthesis* / Q000737:chemistry; D013696:Temperature; D014105:Tosyl Compounds / Q000737:chemistry*
D000476:Alkanesulfonates; D002712:Chlorides; D003432:Cross-Linking Reagents; D005290:Ferric Compounds; D006571:Heterocyclic Compounds; D010710:Phosphates; D014105:Tosyl Compounds; C024555:ferric chloride