Small molecule inhibitors of Myc/Max dimerization and Myc-induced cell transformation.
The preparation and evaluation of a series of inhibitors of Myc/Max dimerization and Myc-induced cell transformation are described providing mycmycin-1 (3) and mycmycin-2 (4).
Department of Molecular and Experimental Medicine, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037, USA.
Jin
J
Shi
James S
JS
Stover
Landon R
LR
Whitby
Peter K
PK
Vogt
Dale L
DL
Boger
D000818:Animals; D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / Q000037:antagonists & inhibitors / Q000378:metabolism*; D002471:Cell Transformation, Neoplastic; D002645:Chickens; D019281:Dimerization; D005347:Fibroblasts / Q000187:drug effects; D006801:Humans; D016271:Proto-Oncogene Proteins c-myc / Q000037:antagonists & inhibitors / Q000378:metabolism*; D012097:Repressor Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D054852:Small Molecule Libraries; D013449:Sulfonamides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D015091:beta-Alanine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; C079439:MXD1 protein, human; D016271:Proto-Oncogene Proteins c-myc; D012097:Repressor Proteins; D054852:Small Molecule Libraries; D013449:Sulfonamides; C546146:mycmycin-1; C546147:mycmycin-2; D015091:beta-Alanine