Palladium-catalysed arylative cyclisation of N-allylacetamides with aryl halides yielding benzyl-substituted oxazolines.
Treatment of N-allylacetamide with aryl halide in the presence of sodium t-butoxide and a palladium catalyst leads to arylative cyclisation to provide the corresponding benzyl-substituted oxazoline in high yield.
Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Kyoto-daigaku Katsura, Nishikyo-ku, Kyoto 615-8510, Japan.
Daishi
D
Fujino
Sayuri
S
Hayashi
Hideki
H
Yorimitsu
Koichiro
K
Oshima
D000081:Acetamides / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D010080:Oxazoles / Q000138:chemical synthesis / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism
D000081:Acetamides; D010080:Oxazoles; D010165:Palladium