Isolated inflammatory myopathy with rimmed vacuoles presenting with dropped head.
We describe an unusual case of inflammatory myopathy with rimmed vacuoles associated with dropped head syndrome. Muscle biopsy in our patient revealed variations in fiber size with fiber necrosis and regeneration, accompanied by many rimmed vacuoles and areas of endomysial cell infiltration. Electron microscopy demonstrated autophagic vacuoles and tubulofilamentous inclusions. This myopathy can cause dropped head syndrome in a subgroup of patients.
Kataoka
Hiroshi
H
Department of Neurology, Nara Medical University, Kashihara, Nara, Japan. hk55@naramed-u.ac.jp
Sugie
Kazuma
K
Terashima
Mari
M
Koizumi
Munehisa
M
Horikawa
Hirosei
H
Nishino
Ichizo
I
Nonaka
Ikuya
I
Ueno
Satoshi
S
D000368:Aged; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006257:Head; D006801:Humans; D008279:Magnetic Resonance Imaging; D018482:Muscle, Skeletal / Q000473:pathology / Q000648:ultrastructure; D009220:Myositis / Q000150:complications* / Q000188:drug therapy / Q000473:pathology*; D009336:Necrosis / Q000473:pathology; D011187:Posture; D011241:Prednisone / Q000627:therapeutic use; D012038:Regeneration; D013577:Syndrome; D016896:Treatment Outcome; D014617:Vacuoles / Q000473:pathology* / Q000648:ultrastructure
D000893:Anti-Inflammatory Agents; D011241:Prednisone