Protein and energy metabolism in type 1 diabetes.
Profound metabolic changes occur in people with type 1 diabetes mellitus during insulin deprivation. These include an increase in basal energy expenditure and reduced mitochondrial function. In addition, protein metabolism is significantly affected during insulin deprivation. A greater increase in whole-body protein breakdown than protein synthesis occurs resulting in a net protein loss. During insulin deprivation the splanchnic bed has a net protein accretion which accounts for the total increase in whole-body protein synthesis while muscle is in a net catabolic state.
Mayo Clinic, 200 First St. SW, Joseph 5-194, Rochester, MN 55905, USA. hebert.sadie@mayo.edu
Sadie L
SL
Hebert
K Sreekumaran
KS
Nair
D001208:Asia; D001481:Basal Metabolism; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism*; D004734:Energy Metabolism; D006801:Humans; D011506:Proteins / Q000378:metabolism*
D011506:Proteins