Oral squamous papilloma: clinical, histologic and immunohistochemical analyses.
Oral squamous papilloma (OSP) is a benign proliferation of the stratified squamous epithelium, which results in a papillary or verrucous exophytic mass. Twelve patients suspected to have oral papilloma underwent excisional biopsy for histopathologic and immunohistochemical analysis. The majority of the patients (75%) were females, and the most prevalent site was the tongue, followed by the palate. The round and whitish form was present in 58.4% of the cases. The lesions were softened/flaccid in 66.7% of cases and a pedunculated attachment was seen in 75% of the lesions. The histopathologic examination revealed hyperparakeratosis, occasional basal hyperplasia, and koilocyte-like cells in 100% of the specimens. Immunohistochemical assays utilizing BP53-12 and Pab240 antibodies for p53 protein showed negative or weak immunostaining (91.6%) for both immunomarkers in all the epithelial layers examined. The findings suggest the benign nature of the lesions and small possibility of becoming malignant.
Carneiro
Thalassa E
TE
Laboratory of Pathology, Federal University of Jequitinhonha and Mucuri Vales (UFVJM), Diamantina, Brazil.
Marinho
Sandra A
SA
Verli
Flaviana D
FD
Mesquita
Ana T M
AT
Lima
Nádia L
NL
Miranda
João L
JL
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009062:Mouth Neoplasms / Q000378:metabolism / Q000473:pathology*; D010212:Papilloma / Q000378:metabolism / Q000473:pathology*; D016159:Tumor Suppressor Protein p53 / Q000032:analysis / Q000096:biosynthesis*; D014764:Viral Proteins / Q000032:analysis; D055815:Young Adult
D016159:Tumor Suppressor Protein p53; D014764:Viral Proteins