Calixarene-entrapped nanoemulsion for uranium extraction from contaminated solutions.
Accidental cutaneous contamination by actinides such as uranium occurring to nuclear power plant workers can lead to their dissemination in other tissues and induce severe damages. Until now, no specific emergency treatment for such contamination has been developed. The aim of the present work was to formulate a tricarboxylic calix[6]arene molecule, known to exhibit good affinity and selectivity for complexing uranium, within a topical delivery system for the treatment of skin contamination. Since calixarene was shown to reduce oil/water interfacial tension, we have designed an oil-in-water nanoemulsion, taking advantage of the small droplet size offering a high contact surface with the contaminated aqueous medium. Characterization of the calixarene nanoemulsion was performed by determination of the oily droplet size, zeta potential and pH, measured as a function of the calixarene concentration. The obtained results have confirmed the surface localization of calixarene molecules being potentially available to extract uranyl ions from an aqueous contaminated solution. In a preliminary experiments, the calixarene nanoemulsion was used for the removal of free uranium from an aqueous contaminated solution. Results showed that the calixarene nanoemulsion extracted up to 80 +/- 5% of uranium, which demonstrates the potential interest of this delivery system for uranium skin decontamination.
Univ Paris Sud, UMR CNRS 8612, IFR 141-ITFM, Faculté de Pharmacie, Châtenay-Malabry, France.
Aurélie
A
Spagnul
Céline
C
Bouvier-Capely
Guillaume
G
Phan
François
F
Rebière
Elias
E
Fattal
D000279:Administration, Cutaneous; D047250:Calixarenes / Q000008:administration & dosage / Q000737:chemistry*; D003666:Decontamination / Q000379:methods*; D004337:Drug Carriers / Q000138:chemical synthesis*; D004339:Drug Compounding / Q000379:methods; D004563:Electrochemistry / Q000379:methods; D004655:Emulsions / Q000008:administration & dosage* / Q000138:chemical synthesis / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D036103:Nanotechnology / Q000379:methods*; D016273:Occupational Exposure; D011848:Radioactive Pollutants / Q000737:chemistry; D012995:Solubility; D013500:Surface Tension; D014501:Uranium / Q000737:chemistry*
D004337:Drug Carriers; D004655:Emulsions; D011848:Radioactive Pollutants; D047250:Calixarenes; D014501:Uranium