Age-related memory decline and apolipoprotein E e4.
The APOE epsilon4 allele is associated with risk of late-onset Alzheimer's disease (AD). Longitudinal memory decline in asymptomatic APOE epsilon4 carriers shows greater acceleration compared with non-carriers, with a possible allele-dose effect, and begins prior to age 60. These results correlate with imaging and neuropathological studies that show AD-like changes at this age and collectively support the existence of a presymptomatic stage of AD.
Department of Neurology, Mayo Clinic, Scottsdale, Arizona 85259, USA. caselli.richard@mayo.edu
Richard J
RJ
Caselli
D000367:Age Factors; D000544:Alzheimer Disease / Q000209:etiology / Q000378:metabolism; D053327:Apolipoprotein E4 / Q000378:metabolism*; D006801:Humans; D008569:Memory Disorders / Q000209:etiology / Q000378:metabolism*
D053327:Apolipoprotein E4