Development and characterization of a lovastatin-loaded self-microemulsifying drug delivery system.
The objective of the work was to develop, optimize and evaluate a self-microemulsifying drug delivery system of the poorly water soluble drug, lovastatin. Solubility of lovastatin was determined in various vehicles. Ternary phase diagrams were constructed to identify the efficient self-emulsification region using oils, surfactants, and co-surfactants in aqueous environment. Optimized formulations were assessed for drug content, spectroscopic clarity, emulsification time, contact angle, zeta potential, particle size and dissolution studies. Zeta potential was measured in absence and presence of oleylamine, a positive charge inducer. On the basis of similarity and dissimilarity of particle size distribution, formulations were characterized using principal component analysis and agglomerative hierarchy cluster analysis, the multivariate statistical analysis. Transmission electron microscopy of selected formulations (F5-F7) confirmed the spherical shape of globules with no signs of coalescence of globules and precipitation of drug, even after 24 h post dilution in distilled water. The relevance of differences in t(50%) and percentage dissolution efficiency was evaluated statistically by two-way ANOVA. Infrared spectroscopy, differential scanning calorimetric and x-ray diffraction studies indicated no incompatibility between drug, oil and surfactants. The results of this study indicate that the self-microemulsifying drug delivery system of lovastatin, owing to nanosize, has potential to enhance its absorption and without interaction or incompatibility between the ingredients.
Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi, Jharkhand-835215, India.
Sandeep Kumar
SK
Singh
Priya Ranjan Prasad
PR
Verma
Balkishen
B
Razdan
D000924:Anticholesteremic Agents / Q000008:administration & dosage / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D055598:Chemical Phenomena; D016000:Cluster Analysis; D004339:Drug Compounding; D016503:Drug Delivery Systems; D004355:Drug Stability; D045703:Emulsifying Agents / Q000737:chemistry*; D004655:Emulsions; D008148:Lovastatin / Q000008:administration & dosage / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D009821:Oils / Q000737:chemistry; D044367:Phase Transition; D012995:Solubility; D013055:Spectrophotometry, Infrared; D013997:Time Factors; D014961:X-Ray Diffraction
D000924:Anticholesteremic Agents; D045703:Emulsifying Agents; D004655:Emulsions; D009821:Oils; D008148:Lovastatin