Total synthesis of aigialomycin D using a one-pot ketene generation-trapping-aromatization sequence.
The total synthesis of aigialomycin D, without the need for phenol protection, was carried out using the C-acylation of a keto-dioxinone dianion, a cascade sequence consisting of ketene generation, alcohol trapping and aromatization, and ring-closing metathesis.
Department of Chemistry, Imperial College, London SW7 2AZ, England.
Frederick
F
Calo
Jeffery
J
Richardson
Anthony G M
AG
Barrett
D003500:Cyclization; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
D018942:Macrolides; C452445:aigialomycin D