Current state of hormone replacement therapy: the case for using trimegestone.
Estrogen deficiency has a negative impact on the quality of life of postmenopausal women and is associated with vasomotor symptoms, insomnia and emotional lability. Other manifestations of estrogen deficiency include dry skin, dry vagina and dyspareunia, in addition to bone loss. Estrogen replacement effectively reverses these changes. The only indication for the administration of a progestogen is to protect the postmenopausal uterus against the potential development of endometrial hyperplasia and carcinoma.
Wahab
May
M
George Eliot Hospital, Nuneaton, Warwickshire, CV10 7DJ, UK. may.wahab@geh.nhs.uk.
Al-Azzawi
Farook
F