Interaction between familial history of obesity and fat intakes on obesity phenotypes.
OBJECTIVE
To evaluate whether familial history of obesity (FHO) interacts with dietary fat intake (DFI) on obesity-related phenotypes.


METHODS
We recruited 664 participants aged between 18 and 55 years. A positive FHO (FHO+) was defined as having at least 1 obese first-degree relative and a negative FHO (FHO-) as no obese first-degree relative. Dietary intakes were collected from a food-frequency questionnaire. Body mass index, weight and waist girth were recorded using standard procedures. Fat mass and fat-free mass were assessed by electrical bioimpedance.


RESULTS
Significant interaction effects (FHO x DFI) were observed for body mass index, weight, waist girth and fat mass (p interaction = 0.05, 0.04, 0.04, 0.02, respectively). Among FHO+ individuals, indices of obesity increased with an increasing amount of DFI, whereas these associations were not observed in FHO- individuals. We also found that FHO+ individuals consuming a high-fat diet were at higher risk of obesity than FHO- individuals consuming a low-fat diet (3.6, CI 2.1-6.2).


CONCLUSIONS
These results suggest a stronger relationship between DFI and obesity-related phenotypes in individuals with FHO+.
Paradis
Ann-Marie
AM
Department of Food Science and Nutrition, Laval University, Quebec City, Que., Canada.
Godin
Gaston
G
Pérusse
Louis
L
Vohl
Marie-Claude
MC
D000293:Adolescent; D000328:Adult; D003430:Cross-Sectional Studies; D004041:Dietary Fats / Q000008:administration & dosage; D004435:Eating / Q000502:physiology*; D005192:Family Health; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology / Q000209:etiology*; D010641:Phenotype; D012307:Risk Factors; D011795:Surveys and Questionnaires; D055815:Young Adult
D004041:Dietary Fats