Follicular dendritic cells in multicentric Castleman disease present human herpes virus type 8 (HHV8)-latent nuclear antigen 1 (LANA1) in a proportion of cases and is associated with an enhanced T-cell response.
Multicentric Castleman disease (MCD) is a rare human herpes virus type 8 (HHV8)-associated lymphoproliferative disorder that occurs more frequently in patients infected with human immunodeficiency virus (HIV). In tissue samples, HHV8-infected plasmablasts localise to the mantle zones of the lymphoid follicles. We revisited the immunohistological features in 25 lymph node (LN) and three spleen samples of MCD. In five (20%) LN and one (33%) spleen sample, HHV8 latent nuclear antigen 1 (LANA1) staining was also noted on the follicular dendritic cells (FDC). The HHV8-positive FDC subgroup of patients had significantly higher numbers of CD3-positive T cells infiltrating the follicles when compared to the HHV8-negative FDC subgroup (P = 0.047). Furthermore, the numbers of HHV8-positive plasmablasts and serum HHV8 viral copy numbers were lower among the HHV8-positive FDC subgroup when compared to the HHV8-negative FDC subgroup (not statistically significant). Our findings show, for the first time, possible 'presentation' of an HHV8 antigen by FDCs in MCD.
El-Daly
Hesham
H
Department of Histopathology, Hammersmith Hospital and Imperial College, London, UK.
Bower
Mark
M
Naresh
Kikkeri N
KN
D000328:Adult; D000368:Aged; D000956:Antigens, Viral / Q000276:immunology* / Q000378:metabolism; D017252:CD3 Complex / Q000276:immunology / Q000378:metabolism; D005871:Castleman Disease / Q000150:complications / Q000276:immunology* / Q000378:metabolism / Q000473:pathology / Q000821:virology; D003713:Dendritic Cells / Q000276:immunology* / Q000378:metabolism / Q000473:pathology / Q000821:virology; D005260:Female; D006678:HIV / Q000276:immunology* / Q000378:metabolism; D015658:HIV Infections / Q000150:complications / Q000276:immunology* / Q000378:metabolism / Q000473:pathology / Q000821:virology; D006566:Herpesviridae Infections / Q000150:complications / Q000276:immunology* / Q000378:metabolism / Q000473:pathology / Q000821:virology; D019288:Herpesvirus 8, Human / Q000276:immunology / Q000378:metabolism; D006801:Humans; D008198:Lymph Nodes / Q000276:immunology / Q000378:metabolism / Q000473:pathology / Q000821:virology; D008297:Male; D008875:Middle Aged; D009687:Nuclear Proteins / Q000276:immunology* / Q000378:metabolism; D013154:Spleen / Q000276:immunology / Q000378:metabolism / Q000473:pathology / Q000821:virology; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism / Q000473:pathology / Q000821:virology
D000956:Antigens, Viral; D017252:CD3 Complex; D009687:Nuclear Proteins; C109540:latency-associated nuclear antigen