Total synthesis of the marine bromotyrosine alkaloid moloka'iakitamide.
The first total synthesis of moloka'iakitamide (1), a recently reported bromotyrosine alkaloid from Pseudoceratina arabica with oxalamide moiety, was achieved in 7 steps from commercially available tyramine (26% overall).
Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University, Sanuki, Kagawa769-2193, Japan.
Makoto
M
Yoshida
Kentaro
K
Yamaguchi
D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D011161:Porifera / Q000737:chemistry*; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000737:chemistry
D000470:Alkaloids; C475724:bromotyrosine; C545780:molokaiakitamide; D014443:Tyrosine