Sphingosine kinase-1: a potential mediator of renal fibrosis.
Renal fibrosis contributes to glomerulosclerosis and tubulointerstitial damage in chronic kidney disease. A well-established pathway implicated in the progression of fibrosis is the induction of connective tissue growth factor by transforming growth factor-beta, resulting in the accumulation of extracellular matrix proteins. Ren and colleagues demonstrate that sphingosine kinase-1 is involved in the regulation of this pathway in the glomerulus. This raises the possibility of targeting sphingosine kinase-1 to prevent fibrosis in chronic kidney disease patients.
University College London, Institute of Child Health, UK. dlong@ich.ucl.ac.uk
David A
DA
Long
Karen L
KL
Price
D000818:Animals; D002908:Chronic Disease; D055513:Connective Tissue Growth Factor / Q000378:metabolism; D018450:Disease Progression; D005355:Fibrosis; D006801:Humans; D007674:Kidney Diseases / Q000188:drug therapy / Q000201:enzymology* / Q000473:pathology; D008246:Lysophospholipids / Q000378:metabolism; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000037:antagonists & inhibitors / Q000378:metabolism*; D050199:Podocytes / Q000187:drug effects / Q000201:enzymology* / Q000473:pathology; D047428:Protein Kinase Inhibitors; D013110:Sphingosine / Q000031:analogs & derivatives / Q000378:metabolism; D053781:Transforming Growth Factor beta2 / Q000378:metabolism; D000099157:Sphingosine Kinase
D055513:Connective Tissue Growth Factor; D008246:Lysophospholipids; D017853:Phosphotransferases (Alcohol Group Acceptor); D047428:Protein Kinase Inhibitors; D013110:Sphingosine; D053781:Transforming Growth Factor beta2; D000099157:Sphingosine Kinase; C060506:sphingosine 1-phosphate