Comparison of the effectiveness of single versus double intrauterine insemination with three different timing regimens.
OBJECTIVE
To compare double insemination with two different single insemination regimens.


METHODS
Prospective study.


METHODS
Tertiary education and research hospital.


METHODS
Four hundred and fifty patients with unexplained infertility, male factor, and ovulatory dysfunction underwent controlled ovarian hyperstimulation with gonadotropin.


METHODS
The patients were divided randomly into three groups: patients in group 1 underwent a single preovulatory intrauterine insemination (IUI) performed 24 hours after hCG administration. Patients in group 2 underwent two IUIs performed 12 and 36 hours after hCG administration. Patients in group 3 underwent a single periovulatory IUI performed 36 hours after hCG administration.


METHODS
Pregnancy rate.


RESULTS
The total pregnancy rate per patient was 14.2 % (64 pregnancies in 450 patients). Group 1 had 17 pregnancies (11.3%), while groups 2 and 3 had 21 (14.0%) and 26 (17.2%) pregnancies, respectively. The difference between the three groups in regard to pregnancy rates was statistically not significant.


CONCLUSIONS
Despite the 36th hour being the preferred timing for IUI, there was no difference regarding pregnancy rates between single 24th hour and double 12th- and 36th-hour inseminations. This finding suggests that the 24th-hour IUI might be preferred in demanding situations.
Zekai Tahir Burak Women's Health Research and Education Hospital, Department of Reproductive Endocrinology, Baskent University School of Medicine, Ankara, Turkey. Electronic address: esratonguc@yahoo.com.
Esra
E
Tonguc
Zekai Tahir Burak Women's Health Research and Education Hospital, Department of Reproductive Endocrinology, Baskent University School of Medicine, Ankara, Turkey.
Turgut
T
Var
Department of Obstetrics and Gynecology, Baskent University School of Medicine, Ankara, Turkey.
Gogsen
G
Onalan
Zekai Tahir Burak Women's Health Research and Education Hospital, Department of Reproductive Endocrinology, Baskent University School of Medicine, Ankara, Turkey.
Sibel
S
Altinbas
Zekai Tahir Burak Women's Health Research and Education Hospital, Department of Reproductive Endocrinology, Baskent University School of Medicine, Ankara, Turkey.
Aytekin
A
Tokmak
Zekai Tahir Burak Women's Health Research and Education Hospital, Department of Reproductive Endocrinology, Baskent University School of Medicine, Ankara, Turkey.
Nafiye
N
Karakaş
Zekai Tahir Burak Women's Health Research and Education Hospital, Department of Reproductive Endocrinology, Baskent University School of Medicine, Ankara, Turkey.
Cavidan
C
Gulerman
D000328:Adult; D006063:Chorionic Gonadotropin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D005260:Female; D005300:Fertility Agents, Female / Q000008:administration & dosage; D006801:Humans; D007246:Infertility / Q000628:therapy*; D007315:Insemination, Artificial / Q000379:methods*; D008297:Male; D010062:Ovulation Induction / Q000379:methods; D011247:Pregnancy; D018873:Pregnancy Rate; D013997:Time Factors; D016896:Treatment Outcome; D014599:Uterus; D055815:Young Adult
D006063:Chorionic Gonadotropin; D005300:Fertility Agents, Female