DNA double-strand breaks come into focus.
The Mre11-Rad50-Nbs1 (MRN) complex senses DNA double-strand breaks and recruits different repair pathway and checkpoint proteins to break foci. Two new studies (Williams et al., 2009; Lloyd et al., 2009) identify Nbs1 as a key factor in this process and reveal how an N-terminal protein recruitment module in Nbs1 binds to different response factors through shared phosphopeptide motifs.
Center for Integrated Protein Science Munich and Munich Center for Advanced Photonics at the Gene Center, Department of Chemistry and Biochemistry, Ludwig-Maximilians-University Munich, 81377 Munich, Germany. hopfner@lmb.uni-muenchen.de
Karl-Peter
KP
Hopfner
D018797:Cell Cycle Proteins / Q000737:chemistry*; D053903:DNA Breaks, Double-Stranded; D004260:DNA Repair; D006801:Humans; D009687:Nuclear Proteins / Q000737:chemistry*; D012568:Schizosaccharomyces / Q000737:chemistry; D029702:Schizosaccharomyces pombe Proteins / Q000737:chemistry* / Q000378:metabolism
D018797:Cell Cycle Proteins; D009687:Nuclear Proteins; D029702:Schizosaccharomyces pombe Proteins