Chantriolide C, a new withanolide glucoside and a new spirostanol saponin from the rhizomes of Tacca chantrieri.
A new withanolide, chantriolide C (1) and a new spirostanol saponin, chantrieroside A (2) were isolated from the rhizomes of Tacca chantrieri, together with another five known steroidal compounds. Their structures were established as (22R)-1alpha,12alpha-diacetoxy-2alpha,3alpha;6alpha,7alpha-diepoxy-27-[(beta-D-glucopyranosyl)oxy]-5alpha-hydroxywith-24-enolide (1) and (25R)-spirost-5-en-3-yl-O-alpha-L-rhamnopyranosyl-(1-->2)-O-[O-beta-D-glucopyranosyl-(1-->4)-alpha-L-rhamnopyranosyl-(1-->3)]-beta-D-glucopyranoside (2). The structures of the new saponins were determined by detailed analysis of their 1 dimensional (1D) and 2D NMR spectra, and chemical evidences.
Zhejiang Provincial Key Laboratory Chinese Medicine Screening, Exploitation & Medicinal Effectiveness Appraise for Cardio-Cerebral Vascular & Nervous System, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou 310027, China. zxxtjk@gmail.com
Lin
L
Zhang
Jiang-Yun
JY
Liu
Li-Zhen
LZ
Xu
Shi-Lin
SL
Yang
D027743:Dioscoreaceae / Q000737:chemistry*; D005960:Glucosides / Q000737:chemistry* / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D027343:Rhizome / Q000737:chemistry; D012503:Saponins / Q000737:chemistry* / Q000302:isolation & purification; D013150:Spirostans / Q000737:chemistry* / Q000302:isolation & purification; D013256:Steroids
D005960:Glucosides; D012503:Saponins; D013150:Spirostans; D013256:Steroids; C545761:chantrieroside A; C478733:chantriolide B; C545760:chantriolide C