Physical forces in myelination and repair: a question of balance?
A recent report in BMC Cell Biology examines how the balance of extracellular forces and intracellular contractions regulate the shape changes required for oligodendrocyte myelination. A failure of remyelination such as seen in multiple sclerosis could be caused by loss of this balance.
MRC Centre for Regenerative Medicine, Centre for Multiple Sclerosis Research, The University of Edinburgh, Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK. nina.g.bauer@ed.ac.uk
Nina G
NG
Bauer
Charles
C
ffrench-Constant
D000818:Animals; D002448:Cell Adhesion; D048430:Cell Shape; D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D040542:Mechanotransduction, Cellular; D009103:Multiple Sclerosis / Q000473:pathology*; D009186:Myelin Sheath / Q000502:physiology*; D012038:Regeneration