Fentanyl pre-treatment alleviates pain during injection of propofol-lipuro premixed with lignocaine.
We studied the effect of fentanyl pretreatment on alleviating pain during the injection of Propofol-Lipuro. One hundred and seventy patients were randomly allocated to receive either 100 mcg of intravenous fentanyl or normal saline (placebo) followed by intravenous Propofol-Lipuro premixed with 20 mg lignocaine. The incidence of injection pain was 32% and 13% in the placebo and fentanyl groups, respectively. We found a statistically significant reduction in incidence of injection pain in the fentanyl group when compared with the placebo group (p<0.003). The number needed to treat was 6 (3.2< 95% CI <15.1). In conclusion, fentanyl pretreatment is effective in alleviating pain during injection of Propofol-Lipuro.
Department of Anaesthesiology & Intensive Care, Hospital Sultanah Aminah, Jalan Abu Bakar, Johor Bahru, Johor, Malaysia. irenelooi@yahoo.com
N
N
Ahmad
Y
Y
Zanariah
S
S
Balan
D000328:Adult; D000758:Anesthesia / Q000379:methods; D018686:Anesthetics, Intravenous / Q000008:administration & dosage* / Q000009:adverse effects; D000779:Anesthetics, Local / Q000008:administration & dosage* / Q000009:adverse effects; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D004338:Drug Combinations; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage*; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage* / Q000009:adverse effects; D008297:Male; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy*; D011229:Preanesthetic Medication / Q000379:methods*; D015742:Propofol / Q000008:administration & dosage* / Q000009:adverse effects; D011446:Prospective Studies; D016896:Treatment Outcome
D018686:Anesthetics, Intravenous; D000779:Anesthetics, Local; D004338:Drug Combinations; D008012:Lidocaine; D005283:Fentanyl; D015742:Propofol