The efficacy of monepantel, an amino-acetonitrile derivative, against gastrointestinal nematodes of sheep in three countries of southern Latin America.
The efficacy of the novel anthelmintic, monepantel (an amino-acetonitrile derivative), was investigated in sheep naturally infected with gastrointestinal nematodes in five studies in Argentina, Brazil, and Uruguay. Monepantel, administered at 2.5 mg/kg liveweight, was highly effective (>99.7%) against Haemonchus contortus, Teladorsagia (Ostertagia) circumcincta, Trichostrongylus axei, Trichostrongylus colubriformis, Cooperia curticei, Cooperia mcmasteri, Cooperia oncophora, Cooperia pectinata, Cooperia punctata, and Nematodirus spathiger, including strains resistant to the older broad-spectrum anthelmintics. Efficacy against C. mcmasteri, C. pectinata, and C. punctata is documented for the first time. The treatment with monepantel was well tolerated by the sheep.
Bustamante
Miguel
M
Novartis Animal Health Chile, Las Condes, Santiago, Chile.
Steffan
Pedro E
PE
Bonino Morlán
Jorge
J
Echevarria
Flavio
F
Fiel
César A
CA
Cardozo
Herculano
H
Castells
Daniel
D
Hosking
Barry C
BC
D000607:Aminoacetonitrile / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000818:Animals; D000969:Antinematodal Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D001118:Argentina; D001938:Brazil; D005243:Feces / Q000469:parasitology; D005260:Female; D005767:Gastrointestinal Diseases / Q000188:drug therapy / Q000662:veterinary*; D008297:Male; D009349:Nematode Infections / Q000188:drug therapy / Q000662:veterinary*; D010270:Parasite Egg Count; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy* / Q000469:parasitology; D016896:Treatment Outcome; D014583:Uruguay
D000969:Antinematodal Agents; D000607:Aminoacetonitrile; C533978:monepantel