Calprotectin levels in the cerebrospinal fluid reflect disease activity in multiple sclerosis.
Calprotectin is produced by activated monocytes and microglia, and cerebrospinal fluid (CSF) levels could be a marker of neuroinflammation. Calprotectin was detectable in CSF from 13.8% of normal controls, compared to 90.5% of patients with neurological infections (p<0.001). In CSF from patients with multiple sclerosis (MS) and clinically isolated demyelinating syndrome, calprotectin was detected in 64.7% within 2 weeks after symptom debut compared to 30.8% between 2 and 4 weeks and 17.0% thereafter (p<0.001). We conclude that CSF calprotectin reflects the disease activity in MS but does not discriminate between MS and other inflammatory or infectious conditions.
Department of Neurology, Oslo University Hospital Ullevål, Oslo, Norway.
Pål
P
Berg-Hansen
Bodvar
B
Vandvik
Magne
M
Fagerhol
Trygve
T
Holmøy
D000328:Adult; D015415:Biomarkers / Q000134:cerebrospinal fluid; D002490:Central Nervous System / Q000276:immunology / Q000503:physiopathology; D002555:Cerebrospinal Fluid / Q000737:chemistry / Q000276:immunology / Q000378:metabolism; D003937:Diagnosis, Differential; D004660:Encephalitis / Q000134:cerebrospinal fluid* / Q000175:diagnosis* / Q000276:immunology; D005260:Female; D006801:Humans; D039841:Leukocyte L1 Antigen Complex / Q000032:analysis / Q000134:cerebrospinal fluid*; D008297:Male; D017628:Microglia / Q000276:immunology / Q000378:metabolism; D008875:Middle Aged; D009000:Monocytes / Q000276:immunology / Q000378:metabolism; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid* / Q000175:diagnosis* / Q000276:immunology; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D013997:Time Factors
D015415:Biomarkers; D039841:Leukocyte L1 Antigen Complex