The immunobiology of viral arthritides.
A large range of human viruses are associated with the development of arthritis or arthralgia. Although there are many parallels with autoimmune arthritides, there is little evidence that viral arthritides lead to autoimmune disease. In humans viral arthritides usually last from weeks to months, can be debilitating, and are usually treated with non-steroidal anti-inflammatory drugs, but with variable success. Viral arthritides likely arise from immunopathological inflammatory responses directed at viruses and/or their products residing and/or replicating within joint tissues. Macrophages recruited by monocyte chemoattractant protein-1 (MCP-1/CCL2) and activated by interferon, and proinflammatory mediators like tumour necrosis factor alpha, interferon gamma, interleukin-6 and interleukin-1beta appear to be common elements in this group of diseases. The challenge for new treatments is to target excessive inflammation without compromising anti-viral immunity. Recent evidence from mouse models suggests targeting MCP-1 or complement may emerge as viable new treatment options for viral arthritides.
Queensland Institute of Medical Research, Australian Centre for International & Tropical Health, Brisbane, 4029, Australia.
Andreas
A
Suhrbier
Suresh
S
Mahalingam
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001170:Arthritis, Infectious / Q000188:drug therapy* / Q000209:etiology / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D015551:Autoimmunity; D003165:Complement System Proteins / Q000378:metabolism; D004195:Disease Models, Animal; D016503:Drug Delivery Systems; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D007596:Joints / Q000276:immunology / Q000378:metabolism / Q000821:virology; D008264:Macrophages / Q000378:metabolism*; D018448:Models, Immunological; D014774:Virulence; D014780:Viruses / Q000235:genetics / Q000276:immunology* / Q000472:pathogenicity
D000893:Anti-Inflammatory Agents; D018836:Inflammation Mediators; D003165:Complement System Proteins