Improvement of functional bloating by an enterovaccine: a preliminary study.
BACKGROUND
Bloating is a fastidious symptom reported by many patients who also have other gastrointestinal functional disorders. Bloating is more common in women, and it is often associated with meals and improves or disappears overnight. No specific treatments are to date available for this disturbing symptom.


OBJECTIVE
to evaluate the effects of an oral enterovaccine (Colifagina) on bloating and other abdominal symptoms in patients with prevalent complaints of functional bloating.


METHODS
One hundred and forty-eight patients with functional bloating according to Rome III criteria were recruited. Questionnaires and a VAS scale on their symptoms were administered at baseline and after four weeks of therapy with Colifagina.


RESULTS
After treatment, a significant amelioration of bloating (p < 0.0001), abdominal pain (p < 0.0001) and flatus (p < 0.0001) was observed; nausea and vomiting scores were not significantly different at the end of the treatment. Subjective wellbeing was also generally improved (p < 0.001) in treated patients.


CONCLUSIONS
Treatment with an enterovaccine may help improve symptoms in patients with functional bloating.
Gastroenterology Section, Cardinal Massaja Hospital, Asti, Italy.
M
M
Grassini
E
E
Battaglia
C
C
Verna
P
P
Niola
A
A
Repici
N
N
Corazzi
G
G
Bassotti
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000293:Adolescent; D000328:Adult; D000818:Animals; D001419:Bacteria / Q000276:immunology*; D001428:Bacterial Vaccines / Q000627:therapeutic use*; D004195:Disease Models, Animal; D005260:Female; D005414:Flatulence / Q000209:etiology / Q000628:therapy*; D006801:Humans; D007407:Interviews as Topic; D008297:Male; D051379:Mice; D008875:Middle Aged; D009325:Nausea / Q000628:therapy; D010147:Pain Measurement; D019936:Probiotics / Q000627:therapeutic use*; D018709:Statistics, Nonparametric; D011795:Surveys and Questionnaires; D016896:Treatment Outcome; D014839:Vomiting / Q000628:therapy
D000276:Adjuvants, Immunologic; D001428:Bacterial Vaccines