[The dynamics of chromosomal aberration frequency in lymphocytes of the human peripheral blood after an acute irradiation].
Biodosimetrical estimation of radiation body burden is based on the counting of chromosomal aberration frequency in lymphocytes of the peripheral blood. This counting was made during a period of time after radiation. However, this frequency differs from counterpart, measured immediately after irradiation. This change caused by elimination of aberrant cells. In order to avoid consistent error in evaluation of dosage it is necessary to know the process generality of elimination temporally. The article contains the results of investigation of aberration frequency dynamics in lymphocytes of 41 patients' peripheral blood. The patients were observed in hospital after Chernobyl accident. The dosage of patients' irradiation varied in the range from 1.2 Gr to 9.8 Gr. Observations had been made during six years or so (from 61 to 2174 days). The results of these observations were used for the research of aberrant cells elimination rate. At the end of the analysis regularities of chromosomal aberration (dicentric and centrical rings) frequency change were obtained. The regularities comply with the exponential law of decreasing with the rate index of elimination (parameter b), which is equal (2.0 +/- 0.5) x 10(3) day(-1) in the range to 10(3) days after radiation. In some cases beyond this interval there was the change of the elimination rate. This fact should be researched additionally. The article contains a model for chromosomal aberration frequency dynamics expression. In analyzed range the b parameter can be constant, but for the extrapolation it in the area of less dosage it is essential to carry on additional investigations.
Petrov
V M
VM
Barteneva
S S
SS
Nugis
V Iu
VIu
D001822:Body Burden; D047852:Chernobyl Nuclear Accident; D002869:Chromosome Aberrations; D004249:DNA Damage; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D006801:Humans; D018655:Lymphocyte Count; D008214:Lymphocytes / Q000528:radiation effects*; D009784:Occupational Diseases / Q000235:genetics* / Q000276:immunology; D011832:Radiation Injuries / Q000235:genetics* / Q000276:immunology; D013997:Time Factors