Synthesis and pharmacological characterization of Disila-AM80 (Disila-tamibarotene) and Disila-AM580, silicon analogues of the RARalpha-selective retinoid agonists AM80 (Tamibarotene) and AM580.
Tacke
Reinhold
R
Universität Würzburg, Institut für Anorganische Chemie, Germany. r.tacke@uni-wuerzburg.de
Müller
Volker
V
Büttner
Matthias W
MW
Lippert
W Peter
WP
Bertermann
Rüdiger
R
Daiss
Jürgen O
JO
Khanwalkar
Harshal
H
Furst
Audrey
A
Gaudon
Claudine
C
Gronemeyer
Hinrich
H
D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D001565:Benzoates / Q000737:chemistry* / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D017646:Organosilicon Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D010795:Phthalic Acids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D018168:Receptors, Retinoic Acid / Q000819:agonists* / Q000378:metabolism; D000072482:Retinoic Acid Receptor alpha; D012825:Silicon / Q000737:chemistry*; D013764:Tetrahydronaphthalenes / Q000737:chemistry* / Q000494:pharmacology
D000970:Antineoplastic Agents; D001565:Benzoates; D017646:Organosilicon Compounds; D010795:Phthalic Acids; C000607071:RARA protein, human; D018168:Receptors, Retinoic Acid; D000072482:Retinoic Acid Receptor alpha; D013764:Tetrahydronaphthalenes; C546695:disila-tamibarotene; C061133:tamibarotene; C068073:Am 580; D012825:Silicon