Effects of sleep deprivation on sleep homeostasis and restoration during methadone-maintenance: a [31]P MRS brain imaging study.
Insomnia afflicts many individuals, but particularly those in chronic methadone treatment. Studies examining sleep deprivation (SD) have begun to identify sleep restoration processes involving brain bioenergetics. The technique ([31])P magnetic resonance spectroscopy (MRS) can measure brain changes in the high-energy phosphates: alpha-, beta-, and gamma-nucleoside triphosphate (NTP). In the present study, 21 methadone-maintained (MM) and 16 control participants underwent baseline (BL), SD (40 wakeful hours), recovery1 (RE1), and recovery2 (RE2) study nights. Polysomnographic sleep was recorded each night and ([31])P MRS brain scanning conducted each morning using a 4T MR scanner (dual-tuned proton/phosphorus head-coil). Interestingly, increases in total sleep time (TST) and sleep efficiency index (SEI) commonly associated with RE sleep were not apparent in MM participants. Analysis of methadone treatment duration revealed that the lack of RE sleep increases in TST and SEI was primarily exhibited by short-term MM participants (methadone <12 months), while RE sleep in long-term MM (methadone >12 months) participants was more comparable to control participants. Slow wave sleep increased during RE1, but there was no difference between MM and control participants. Spectral power analysis revealed that compared to control participants; MM participants had greater delta, theta, and alpha spectral power during BL and RE sleep. ([31])P MRS revealed that elevations in brain beta-NTP (a direct measure of ATP) following RE sleep were greater in MM compared to control participants. Results suggest that differences in sleep and brain chemistry during RE in MM participants may be reflective of a disruption in homeostatic sleep function.
Behavioral Pharmacology Research Laboratory, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, MA 02472, USA. gtrksak@mclean.harvard.edu
George H
GH
Trksak
J Eric
JE
Jensen
David T
DT
Plante
David M
DM
Penetar
Wendy L
WL
Tartarini
Melissa A
MA
Maywalt
Michael
M
Brendel
Cynthia M
CM
Dorsey
Perry F
PF
Renshaw
Scott E
SE
Lukas
D000328:Adult; D001921:Brain / Q000502:physiology / Q000503:physiopathology; D004334:Drug Administration Schedule; D004562:Electrocardiography; D004569:Electroencephalography / Q000379:methods; D004585:Electrooculography; D006706:Homeostasis; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008691:Methadone / Q000009:adverse effects / Q000627:therapeutic use*; D008875:Middle Aged; D012890:Sleep / Q000502:physiology*; D012892:Sleep Deprivation / Q000139:chemically induced / Q000503:physiopathology*; D055815:Young Adult
D008691:Methadone