Current and future uses of candesartan in the treatment of heart failure.
Candesartan is an angiotensin receptor antagonist that is long acting, well absorbed from the gastrointestinal tract and demonstrates an insurmountable receptor antagonism. It is an effective once-daily antihypertensive therapy that maintains good control of blood pressure for over 24 h. More recently, candesartan was shown to be an effective therapy for heart failure patients, producing a significant reduction in mortality and morbidity. Importantly, the studies have demonstrated that candesartan is effective in heart failure patients intolerant to angiotensin-converting enzyme inhibitors (ACE-I), as well as in addition to ACE-I. This paper reviews the data supporting the use of candesartan to treat patients with clinical heart failure.
McKelvie
Robert S
RS
HHSC-General Division, 237 Barton Street East, Hamilton, Ontario, L8L 2X2, Canada. mckelrob@hhsc.ca