Dietary n-3 polyunsaturated fatty acids enhance metastatic dissemination of murine T lymphoma cells.
Epidemiological investigation and animal studies have shown that dietary n-3 PUFA prevent the development and progression of certain types of cancer. However, conflicting results have been reported by the few studies that focused on the effect of dietary n-3 PUFA on the development of metastases. In the present study, we investigated the metastatic dissemination of murine T lymphoma lines with different metastatic potential transplanted into mice fed a fish oil diet, compared with mice fed a maize oil diet. Transplantation of highly metastatic S11 cells into animals fed a fish oil diet induced a large lymphomatoid infiltration in the spleen, associated with an eight-fold increase in spleen weight, compared with normal animals on the same diet. In contrast, only a limited increase in spleen weight was found in animals transplanted with S11 cells while fed a maize oil diet. No significant increase in spleen weight was found in animals transplanted with low-metastatic 164T2 cells regardless of whether they were fed a fish oil or a maize oil diet. At the end of experiment, an overt cachexia was shown by animals fed a fish oil diet transplanted with S11 cells, but not by those transplanted with 164T2 cells. The particularly high pro-metastatic effect of dietary n-3 PUFA on S11 cells rules out the generalisation that dietary n-3 PUFA inhibit tumour growth and progression.
Department of Experimental Pathology and Oncology, University of Florence, Italy.
Antonella
A
Mannini
Nadja
N
Kerstin
Lido
L
Calorini
Gabriele
G
Mugnai
Salvatore
S
Ruggieri
D000818:Animals; D002100:Cachexia / Q000209:etiology; D015525:Fatty Acids, Omega-3 / Q000633:toxicity*; D005260:Female; D005395:Fish Oils / Q000633:toxicity*; D016399:Lymphoma, T-Cell / Q000150:complications / Q000473:pathology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009362:Neoplasm Metastasis; D009368:Neoplasm Transplantation; D010938:Plant Oils / Q000633:toxicity; D013154:Spleen / Q000473:pathology; D014407:Tumor Cells, Cultured; D015430:Weight Gain / Q000187:drug effects
D015525:Fatty Acids, Omega-3; D005395:Fish Oils; D010938:Plant Oils