Clinically controlled study on children's infectious mononucleosis treated by Chinese medicine.
OBJECTIVE
To evaluate the clinical efficacy and safety of Chinese drugs for the treatment of children's infectious mononucleosis (CIM).


METHODS
Sixty CIM patients were assigned into the treated group and the control group, patients in the treated group were administered with Chinese herbal decoction, and those in the control group were treated with intravenous dripping of ganciclovir 10 mg/kg per day, for a treatment course of 14 days.


RESULTS
The total effective rate was 96.0% in the treated group and 97.1% in the control group, showing insignificant difference between groups. The efficacy in the treated group was superior to that in the control group on the fever clearance time (3.0+/-1.5 days vs 4.9+/-3.9 days ) and the disappearance time of cervical lymph node swelling (0.8+/-1.0 score vs 1.5+/-1.2 score), showing statistical significance (all P<0.05). T-cell subsets were markedly improved in both groups after treatment. Adverse reaction occurred in four cases of the control group.


CONCLUSIONS
Using Chinese herbs for clearing heat, removing toxin, activating blood circulation, and dissolving stasis is effective and safe for the treatment of CIM. It can effectively improve the clinical symptoms and shows a certain effect on immune regulation.
Beijing Children's Hospital Affiliated to Capital Medical University, Beijing, China.
Yuan
Y
Yao
Hong-mei
HM
Duan
Hui-min
HM
Yan
Xiao-fang
XF
Zhen
Yu-chen
YC
Pan
Yao
Y
Yao
Li
L
Chen
Xue-fang
XF
Jing
Hai-lun
HL
Chen
D015703:Antigens, CD / Q000276:immunology; D002648:Child; D004854:Herpesvirus 4, Human / Q000235:genetics; D006801:Humans; D007244:Infectious Mononucleosis / Q000188:drug therapy* / Q000276:immunology; D008516:Medicine, Chinese Traditional; D016133:Polymerase Chain Reaction
D015703:Antigens, CD