Linking the cell cycle to histone modifications: Dot1, G1/S, and cycling K79me2.
In a recent issue of Molecular Cell, Schulze et al. (2009) described distinct distributions and regulation of Dot1-dependent methylation states at lysine 79 on histone H3 and showed cell-cycle regulation of K79 dimethylation on genes expressed during the G1/S phase.
Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK. jane.mellor@bioch.ox.ac.uk
Jane
J
Mellor
D002453:Cell Cycle / Q000235:genetics; D021901:DNA, Intergenic; D016193:G1 Phase; D015966:Gene Expression Regulation, Fungal; D011495:Histone-Lysine N-Methyltransferase / Q000235:genetics / Q000378:metabolism*; D006657:Histones / Q000235:genetics / Q000378:metabolism*; D008239:Lysine; D008745:Methylation; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism*; D009707:Nucleosomes / Q000378:metabolism*; D016366:Open Reading Frames; D011401:Promoter Regions, Genetic; D011499:Protein Processing, Post-Translational; D016196:S Phase; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000254:growth & development / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism*; D054875:Ubiquitination
D021901:DNA, Intergenic; D006657:Histones; D009687:Nuclear Proteins; D009707:Nucleosomes; D029701:Saccharomyces cerevisiae Proteins; C416235:Dot1 protein, S cerevisiae; D011495:Histone-Lysine N-Methyltransferase; D008239:Lysine