Autophagy in Mammalian antiviral immunity.
Autophagy plays diverse roles in cellular adaptation to stress and promotes vital housekeeping functions by recycling unused or damaged organelles and proteins. As an innate immune defense pathway, autophagy also protects against infection with diverse pathogens, including viruses. Autophagy combats infections with both RNA and DNA viruses, and may function by degrading viral components, by promoting the survival of virally infected cells, and/or by activating innate and adaptive immunity. Viruses have evolved counter-mechanisms to evade host autophagy in order to promote their own survival. This chapter will highlight recent advances and unanswered questions relating to autophagy in mammalian antiviral immunity.
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Anthony
A
Orvedahl
Beth
B
Levine
D018354:Alphavirus Infections / Q000276:immunology; D000818:Animals; D001343:Autophagy / Q000276:immunology*; D006561:Herpes Simplex / Q000276:immunology; D018259:Herpesvirus 1, Human / Q000276:immunology; D054884:Host-Pathogen Interactions / Q000276:immunology*; D006801:Humans; D012845:Sindbis Virus / Q000276:immunology; D014777:Virus Diseases / Q000276:immunology* / Q000821:virology