Effect of qiming granule on retinal blood circulation of diabetic retinopathy: a multicenter clinical trial.
OBJECTIVE
To objectively assess the effect of Qiming Granule in the treatment of diabetic retinopathy (DR) by fluorescence fundus angiography (FFA).


METHODS
In a multi-center, randomized, parallel controlled clinical trial, patients with DR were randomly assigned to the control group (calcium dobesilate capsule) and the test group (Qiming Granule). Changes in the retinal blood circulation time were recorded by FFA after 3 months of medication.


RESULTS
Significant reduction was observed in the retinal arterio-venous circulation time (AVCT) in both groups (P<0.01), the value was 7.635+/-3.149 s before treatment and 5.165 +/-3.382 s after treatment in the treated group, and 7.737+/-3.413 s and 5.313+/-3.472 s in the control group respectively. Qiming Granule also reduced the arm-to-retinal circulation time (ARCT, P<0.05). The value was 17.867+/-3.872 s before treatment and 15.643+/-4.648 s after treatment in the treated group, and 17.217+/-3.833 s and 16.312+/-3.613 s in the control group (P>0.05) respectively. The ARCT in the tested group was reduced, with a statistically significant difference post-medication (P<0.01).


CONCLUSIONS
As a Chinese medicine complex prescription, Qiming Granule may alleviate retinal hypoxia and ischemia by increasing retinal blood flow and improving the blood circulation.
Department of Ophthalmology, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Xiang-xia
XX
Luo
Jun-guo
JG
Duan
Pin-zheng
PZ
Liao
Lie
L
Wu
Yang-gui
YG
Yu
Bo
B
Qiu
Yu-liang
YL
Wang
Yu-min
YM
Li
Zheng-qin
ZQ
Yin
Xiao-ling
XL
Liu
Ke
K
Yao
D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D003930:Diabetic Retinopathy / Q000188:drug therapy* / Q000503:physiopathology; D004365:Drugs, Chinese Herbal / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use*; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D008297:Male; D008875:Middle Aged; D012171:Retinal Vessels / Q000187:drug effects* / Q000503:physiopathology
D004365:Drugs, Chinese Herbal; C546211:qiming