Intracellular localization and cytotoxicity of spherical mesoporous silica nano- and microparticles.
This work evaluates the cytotoxicity of spherical mesoporous silica (MS) nano- and microparticles and investigates the effects of particle size, concentration, biodegradation products of MS, residual surfactant, and surfactant removal by extraction and calcination on the cytotoxicity. The results from the intracellular localization of spherical MS nano- and microparticles with different sizes reveal the mechanism for their cytotoxicity and that the smaller particles in nanoscale are more easily endocytosed and consequently located within lysosomes.
State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, P.R. China.
Qianjun
Q
He
Zhiwen
Z
Zhang
Yu
Y
Gao
Jianlin
J
Shi
Yaping
Y
Li
D000818:Animals; D019556:COS Cells; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002522:Chlorocebus aethiops; D004705:Endocytosis; D005260:Female; D006801:Humans; D008247:Lysosomes / Q000378:metabolism; D046529:Microscopy, Electron, Transmission; D008863:Microspheres; D054118:Nanospheres / Q000737:chemistry / Q000648:ultrastructure; D036103:Nanotechnology; D010316:Particle Size; D053838:Scattering, Small Angle; D012822:Silicon Dioxide / Q000493:pharmacokinetics* / Q000633:toxicity*; D013501:Surface-Active Agents / Q000633:toxicity; D014961:X-Ray Diffraction
D013501:Surface-Active Agents; D012822:Silicon Dioxide