Oscillatory Notch-pathway activity in a delay model of neuronal differentiation.
Lateral inhibition resulting from a double-negative feedback loop underlies the assignment of different fates to cells in many developmental processes. Previous studies have shown that the presence of time delays in models of lateral inhibition can result in significant oscillatory transients before patterned steady states are reached. We study the impact of local feedback loops in a model of lateral inhibition based on the Notch signaling pathway, elucidating the roles of intracellular and intercellular delays in controlling the overall system behavior. The model exhibits both in-phase and out-of-phase oscillatory modes and oscillation death. Interactions between oscillatory modes can generate complex behaviors such as intermittent oscillations. Our results provide a framework for exploring the recent observation of transient Notch-pathway oscillations during fate assignment in vertebrate neurogenesis.
Momiji
Hiroshi
H
Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, United Kingdom. h.momiji@warwick.ac.uk
Monk
Nicholas A M
NA
D002454:Cell Differentiation; D025461:Feedback, Physiological; D042541:Intracellular Space / Q000378:metabolism; D016014:Linear Models; D008954:Models, Biological; D008959:Models, Neurological; D009415:Nerve Net / Q000166:cytology; D009474:Neurons / Q000166:cytology*; D051880:Receptors, Notch / Q000378:metabolism*; D015398:Signal Transduction; D013997:Time Factors
D051880:Receptors, Notch