Differential response of Vibrio cholerae planktonic and biofilm cells to autoinducer 2 deficiency.
The formation of biofilm communities enhances the persistence of Vibrio cholerae in aquatic environments. Biofilm production is repressed by the quorum-sensing regulator HapR in response to the accumulation of CAI-1 and AI-2. CAI-1 is the strongest input signal activating HapR, whereas the role of AI-2 remains ill-defined. In the present study, we show that a V. cholerae luxS (AI-2-defective) mutant made increased biofilm. Interestingly, cells in the biofilm were more responsive to AI-2 deficiency than cells from the planktonic population.
Morehouse School of Medicine Department of Microbiology, SW Atlanta, Georgia 30310, USA.
Syed A
SA
Ali
Jorge A
JA
Benitez
D018441:Biofilms; D002771:Cholera / Q000382:microbiology; D006714:Homoserine / Q000031:analogs & derivatives* / Q000172:deficiency; D006801:Humans; D007783:Lactones; D053038:Quorum Sensing; D014734:Vibrio cholerae / Q000166:cytology / Q000502:physiology*
D007783:Lactones; C091088:N-octanoylhomoserine lactone; D006714:Homoserine