[Relationship between C-telopeptides of type I collagen serum values with bone mineral density and antiosteoporotic drug intake in postmenopausal women. Preliminary data from the FRODOS study].
OBJECTIVE
Few studies have addressed the role of bone turnover markers (BTM) in Spanish postmenopausal women. The goal of the study was to analyse the relationship between crosslinked C-telopeptides of type I collagen (betaCTXs) serum values and bone mineral density (BMD) and antiosteoporotic drug intake in a large sample of postmenopausal women.


METHODS
We have recruited 1495 women aged 59-70 years (15.7 years since menopause) randomly selected from the general population within the cross-sectional phase of a cohort study. All participants had undergone betaCTXs testing in fast state, BMD scan of spine and femur (WHO classification) and a clinic-epidemiological questionnaire with specific drug intake record.


RESULTS
Twenty-six (26) % of the participants had osteoporosis and 18% took antiosteoporotic drugs. In women who did not receive antiosteoporotic drugs, betaCTXs was higher in participants with osteoporosis and osteopenia when compared with those with normal BMD (p < 0.05). In women under therapy, betaCTXs was significantly lower compared with women with no therapy and the mean values were similar to those of premenopausal women.


CONCLUSIONS
In this group of unselected postmenopausal women, betaCTXs values are associated with BMD categories and showed a marked decrease in those taking antiosteoporotic drugs.
Kanterewicz
Eduardo
E
Unidad de Reumatología, Consorci Hospitalari De Vic, España. ekanterewicz@chv.cat
Puigoriol
Emma
E
Peris
Pilar
P
Del Río
Luis
L
Rosique
Pau
P
Yáñez
Aina
A
D000368:Aged; D015519:Bone Density; D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D024042:Collagen Type I; D004363:Drug Utilization / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D008875:Middle Aged; D010024:Osteoporosis / Q000453:epidemiology / Q000517:prevention & control*; D010446:Peptide Fragments / Q000097:blood*; D010455:Peptides; D017698:Postmenopause; D011347:Procollagen / Q000097:blood*; D011446:Prospective Studies
D050071:Bone Density Conservation Agents; D024042:Collagen Type I; D010446:Peptide Fragments; D010455:Peptides; D011347:Procollagen; C052929:collagen type I trimeric cross-linked peptide