Hydrogen sulfide induces nitric oxide release from nitrite.
Hydrogen sulfide has recently been considered to have an important role as a gasotransmitter in the cardiovascular system as well as in the central nervous system, but its action seems directly related to the presence of nitric oxide/nitric oxide-derivatives. We report here chemical evidence that emphasizes a prominent role of the hydrogen sulfide as cofactor of NO-derivatives in inducing nitric oxide release.
Grossi
Loris
L
Dipartimento di Chimica Organica A. Mangini, Università di Bologna, I-40136 Bologna, Italy. loris.grossi@unibo.it
D002318:Cardiovascular Diseases / Q000378:metabolism; D002319:Cardiovascular System / Q000378:metabolism; D002490:Central Nervous System / Q000378:metabolism; D002493:Central Nervous System Diseases / Q000378:metabolism; D006862:Hydrogen Sulfide / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D009569:Nitric Oxide / Q000378:metabolism*; D012977:Sodium Nitrite / Q000378:metabolism*
D009569:Nitric Oxide; D012977:Sodium Nitrite; D006862:Hydrogen Sulfide