Modified Atkins diet for the treatment of nonconvulsive status epilepticus in children.
The authors describe the use of a modified Atkins diet for the treatment of 2 children with nonconvulsive status epilepticus. Patient 1 was a 4-year-and-11-month-old girl diagnosed with frontal lobe epilepsy. Since the age of 3 years and 10 months, she had daily nonconvulsive status epilepticus resistant to antiepileptic agents. Patient 2 was a 5-year-and-5-month-old girl with subcortical band heterotopia. She had nonconvulsive status epilepticus daily since the age of 5 years. They were treated with the modified Atkins diet, in which carbohydrate intake was restricted to 10 g/d without restriction on protein, caloric, or fluid intake. The nonconvulsive status epilepticus disappeared 5 and 10 days after the initiation of the diet treatment, respectively. They have been on the diet treatment and free from nonconvulsive status epilepticus for 19 and 4 months, respectively. The modified Atkins diet appears to be very effective for the treatment of nonconvulsive status epilepticus.
Kumada
Tomohiro
T
Department of Pediatrics, Shiga Medical Center for Children, Shiga, Japan. tkumada@mccs.jp
Miyajima
Tomoko
T
Kimura
Nobusuke
N
Saito
Keiko
K
Shimomura
Hideki
H
Oda
Nozomi
N
Fujii
Tatsuya
T
D002241:Carbohydrates / Q000172:deficiency; D002540:Cerebral Cortex / Q000378:metabolism / Q000503:physiopathology; D002675:Child, Preschool; D050528:Diet, Carbohydrate-Restricted; D004040:Dietary Carbohydrates / Q000009:adverse effects / Q000378:metabolism; D004569:Electroencephalography; D004827:Epilepsy / Q000178:diet therapy* / Q000503:physiopathology; D005071:Evoked Potentials / Q000502:physiology; D005260:Female; D005526:Food, Formulated; D006801:Humans; D007657:Ketone Bodies / Q000097:blood; D020127:Recovery of Function / Q000502:physiology; D013226:Status Epilepticus / Q000178:diet therapy* / Q000503:physiopathology; D016896:Treatment Outcome
D002241:Carbohydrates; D004040:Dietary Carbohydrates; D007657:Ketone Bodies