Synthesis of novel 3,5-dichloro-2-arylpyridines by palladium acetate-catalyzed ligand-free Suzuki reactions in aqueous media.
A highly efficient palladium acetate-catalyzed ligand-free Suzuki reaction of 2,3,5-trichloropyridine with arylboronic acids in aqueous phase was developed. High yields of 3,5-dichloro-2-arylpyridines, a simple Pd source, absence of ligands, and environmentally benign as well as mild reaction conditions are important features of this method.
Hu
Huanan
H
College of Pharmaceutial and Chemical Engineering, Taizhou University, Linhai 317000, China. hhn12192000@yahoo.com.cn
Ge
Changhua
C
Zhang
Anjiang
A
Ding
Lisheng
L
D000085:Acetates / Q000737:chemistry*; D001897:Boronic Acids / Q000737:chemistry; D002384:Catalysis; D008024:Ligands; D008956:Models, Chemical; D009942:Organometallic Compounds / Q000737:chemistry*; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry; D012996:Solutions; D012997:Solvents / Q000737:chemistry; D013997:Time Factors; D014867:Water / Q000737:chemistry*
D000085:Acetates; D001897:Boronic Acids; D008024:Ligands; D009942:Organometallic Compounds; D011725:Pyridines; D012996:Solutions; D012997:Solvents; D014867:Water; C516071:palladium(II) acetate