Androgen receptor gene sequence and basal cortisol concentrations predict men's hormonal responses to potential mates.
Exposure to potential mates triggers rapid elevations of testosterone and glucocorticoid concentrations in males of many non-human species, and preliminary studies support similar effects in human males. The human studies have all reported large individual differences in these responses, however, and the present study tested whether specific biological variables may help explain these differences. Replicating past research, the present study found that men's salivary testosterone and cortisol concentrations increased after a brief conversation with a young woman, but did not change (or slightly decreased) after a conversation with a young man. In addition, smaller numbers of CAG repeats in men's androgen receptor gene, and lower baseline cortisol concentrations, each predicted larger testosterone responses to the interactions with women. The CAG repeat finding demonstrates that a specific genetic polymorphism predicts physiological responses to social interactions that may in turn have important downstream consequences on men's mating behaviour. The effects of cortisol are consistent with past demonstrations of glucocorticoid inhibition of testosterone production and show that such inhibition also affects testosterone responses to social stimuli. In sum, the present study both confirms men's hormonal reactions to potential mates and identifies novel biological variables that predict individual differences in these responses.
Department of Psychology, University of California, Santa Barbara, CA 93106, USA. roney@psych.ucsb.edu
James R
JR
Roney
Zachary L
ZL
Simmons
Aaron W
AW
Lukaszewski
D000293:Adolescent; D004247:DNA / Q000737:chemistry / Q000235:genetics; D005260:Female; D014644:Genetic Variation / Q000502:physiology*; D005838:Genotype; D006801:Humans; D006854:Hydrocortisone / Q000502:physiology*; D008297:Male; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000502:physiology*; D011897:Random Allocation; D011944:Receptors, Androgen / Q000235:genetics / Q000502:physiology*; D012044:Regression Analysis; D012463:Saliva / Q000737:chemistry; D012725:Sexual Behavior / Q000502:physiology*; D013739:Testosterone / Q000502:physiology*; D018911:Trinucleotide Repeats / Q000235:genetics; D055815:Young Adult
C410798:AR protein, human; D011944:Receptors, Androgen; D013739:Testosterone; D004247:DNA; D006854:Hydrocortisone