Synthesis and characterization of fluorescent magneto polymeric nanoparticles (FMPNs) for bimodal imaging probes.
Novel bifunctional fluorescent magneto polymeric nanoprobes (FMPNs) were synthesized to provide simultaneous diagnostic information via magnetic resonance imaging (MRI) and optical imaging. FMPNs consist of ultra-sensitive magnetic nanocrystals that function as MR probes combined with Nile Red, which functions as a fluorescent probe. FMPNs were encapsulated by a nano-emulsion method in polyvinyl alcohol (PVA, 87-89% hydrolyzed) through a matrix of polymethyl methacrylate (PMMA). FMPNs exhibited excellent colloidal stability and monodispersity. The production of MR and optical images demonstrated that FMPNs have potential as dual-mode imaging agents.
Department of Chemical and Biomolecular Engineering, College of Engineering, Yonsei University, Seoul 120-749, Republic of Korea. parkys5001@yonsei.ac.kr
Joseph
J
Park
Jaemoon
J
Yang
Jaemin
J
Lee
Eun-Kyung
EK
Lim
Jin-Suck
JS
Suh
Yong-Min
YM
Huh
Seungjoo
S
Haam
D003102:Colloids / Q000737:chemistry; D003952:Diagnostic Imaging / Q000379:methods*; D052203:Ferrosoferric Oxide / Q000138:chemical synthesis / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008280:Magnetics; D046529:Microscopy, Electron, Transmission; D008856:Microscopy, Fluorescence; D057054:Molecular Imaging / Q000379:methods; D053758:Nanoparticles / Q000737:chemistry*; D009994:Osmolar Concentration; D010078:Oxazines / Q000737:chemistry; D010316:Particle Size; D011108:Polymers / Q000737:chemistry*; D019904:Polymethyl Methacrylate / Q000737:chemistry; D011142:Polyvinyl Alcohol / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties; D013818:Thermogravimetry; D014961:X-Ray Diffraction
D003102:Colloids; D005456:Fluorescent Dyes; D010078:Oxazines; D011108:Polymers; D011142:Polyvinyl Alcohol; D019904:Polymethyl Methacrylate; C044808:nile red; D052203:Ferrosoferric Oxide