[Analysis the relation of adults HBV vicinal failure and T cell subset, HLA-DR rang gene phenotype].
OBJECTIVE
To study and explore the relativity of adults HBV vicinal failure and HLA-DR, T cell subset, trace viruses infection. To accumulate date for formulating preventing adult HBV infection prophylactic-therapeutic measures.


METHODS
Select 20 adults randomly who had vaccinated with 10 microgYDV and produced anti-HBS successfully, and another 20 hadn't produced anti-HBs to form two groups-defeated group and contral group. Blood samples from two groups were taken for detecting the level of DR range gene phenotype: T cell subset, white blood cell HLA-DR, HLA-B27, HLA DRB1 * 07, DRB1* 04, DRB1 * 1001, DQB1 * 0401 and so on.


RESULTS
The level of CD4(-)/CD8(-) is lower in the infection group than in healthy group. But the average level of HLA-DR and HLA-B27 is higher in the infection group. The differences of HLA DRB1 * 07 gene frequency between two groups were significant (P <0.05), but the levels of CD3, CD4, CD8, CD7, CD4/CD8 and HLA DRB1 * 04, DRB1 * 1001, DQB1 * 0401 were not significant.


CONCLUSIONS
The failure of HBV vaccination on adults may have relation to HLA-DR, HLA-B27, HLA DRB1 * 07, CD4(-)/CD8(-), etc.
Center for Disease Control of Ninghai County, Ninghai 315600, Zhejiang, China.
Dan-Biao
DB
Hu
Shi-Ke
SK
Liu
Li-Li
LL
Zhao
Ai-Ping
AP
Xu
Ying-Zhi
YZ
Hong
Pin-Yuan
PY
Cao
D000328:Adult; D006684:HLA-DR Antigens / Q000235:genetics* / Q000276:immunology; D006508:Hepatitis Antibodies / Q000097:blood; D006509:Hepatitis B / Q000235:genetics* / Q000276:immunology* / Q000517:prevention & control / Q000821:virology; D017325:Hepatitis B Vaccines / Q000008:administration & dosage / Q000276:immunology*; D006515:Hepatitis B virus / Q000235:genetics / Q000276:immunology*; D006801:Humans; D010641:Phenotype; D016176:T-Lymphocyte Subsets / Q000276:immunology*
D006684:HLA-DR Antigens; D006508:Hepatitis Antibodies; D017325:Hepatitis B Vaccines