The effects of short-duration exercise on arterial stiffness in patients with stable coronary artery disease.
Arterial stiffness is an important contributor to the development of cardiovascular disease. We investigated the effect of short duration exercise using the treadmill test on arterial stiffness in the presence of coronary artery disease. We enrolled patients with and without coronary artery diseases (CAD and control group, 50 patients each) referred for treadmill testing. Brachial-ankle pulse wave velocity (baPWV) were measured before and after treadmill testing. Values of baPWV were significantly reduced at 10 min after exercise in both groups, more in the CAD group than in the control group (baseline baPWV and post-exercise change [cm/sec]: 1,527+/-245 and -132+/-155 in the CAD group, 1,439+/-202 and -77+/-93 in the control group, respectively, P for change in each group <0.001, P for difference in changes between the two groups <0.001). These findings persisted after adjusting for age, body mass index, systolic blood pressure, mean arterial pressure (MAP), MAP decreases, and baseline baPWV. Significant post-exercise baPWV reductions were observed in both groups, and more prominently in the CAD group. This finding suggests that short-duration exercise may effectively improve arterial stiffness even in patients with stable coronary artery disease.
Division of Cardiology, Cardiac and Vascular Center, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Jidong
J
Sung
Jeong Hoon
JH
Yang
Soo Jin
SJ
Cho
Sun Hee
SH
Hong
Eun Hee
EH
Huh
Seung Woo
SW
Park
D000328:Adult; D000368:Aged; D000842:Ankle / Q000098:blood supply; D055109:Ankle Brachial Index; D001158:Arteries / Q000503:physiopathology*; D001783:Blood Flow Velocity; D001916:Brachial Artery / Q000502:physiology; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy; D004548:Elasticity; D005081:Exercise Therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests