DNA double-strand breaks come into focus.
The Mre11-Rad50-Nbs1 (MRN) complex senses DNA double-strand breaks and recruits different repair pathway and checkpoint proteins to break foci. Two new studies (Williams et al., 2009; Lloyd et al., 2009) identify Nbs1 as a key factor in this process and reveal how an N-terminal protein recruitment module in Nbs1 binds to different response factors through shared phosphopeptide motifs.
Hopfner
Karl-Peter
KP
Center for Integrated Protein Science Munich and Munich Center for Advanced Photonics at the Gene Center, Department of Chemistry and Biochemistry, Ludwig-Maximilians-University Munich, 81377 Munich, Germany. hopfner@lmb.uni-muenchen.de
D018797:Cell Cycle Proteins / Q000737:chemistry*; D053903:DNA Breaks, Double-Stranded; D004260:DNA Repair; D006801:Humans; D009687:Nuclear Proteins / Q000737:chemistry*; D012568:Schizosaccharomyces / Q000737:chemistry; D029702:Schizosaccharomyces pombe Proteins / Q000737:chemistry* / Q000378:metabolism
D018797:Cell Cycle Proteins; D009687:Nuclear Proteins; D029702:Schizosaccharomyces pombe Proteins