Antibacterial activity of ceftazidime (GR 20263) against routine hospital isolates and highly resistant strains of enterobacteriaceae and Pseudomonas aeruginosa.
Ceftazidime was found to be highly active against routine hospital isolates of strains of Enterobacteriaceae such as Escherichia coli, Klebsiella aerogenes, Enterobacter cloacae and Proteus mirabilis, with the mean MICs varying between 0.11 and 0.75 mg/l. It had marked activity against Pseudomonas aeruginosa with a mean MIC of 1.8 mg/l which was comparable to tobramycin (11 mg/l) and superior to other aminoglycosides, penicillins and cefotaxime. Although ceftazidime was considerably more active than cefuroxime and cefamandole against E. coli, K. aerogenes and Ent. cloacae, its activity against strains with multi-antibiotic resistance and marked beta-lactamase production was much diminished, with mean MICs between 5 and 21 mg/l. These results with ceftazidime suggest it will be a valuable parenteral compound in the treatment of severe bacterial infections due to strains of the Enterobacteriaceae.
Department of Microbiology, Wycombe General Hospital, High Wycombe, Buckinghamshire, England.
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Leigh
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Nisbet
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002442:Ceftazidime / Q000494:pharmacology*; D003428:Cross Infection / Q000382:microbiology*; D024881:Drug Resistance, Bacterial; D004755:Enterobacteriaceae / Q000187:drug effects*; D004756:Enterobacteriaceae Infections / Q000382:microbiology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D011552:Pseudomonas Infections / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D002442:Ceftazidime