Sensory contributions to impaired emotion processing in schizophrenia.
Both emotion and visual processing deficits are documented in schizophrenia, and preferential magnocellular visual pathway dysfunction has been reported in several studies. This study examined the contribution to emotion-processing deficits of magnocellular and parvocellular visual pathway function, based on stimulus properties and shape of contrast response functions. Experiment 1 examined the relationship between contrast sensitivity to magnocellular- and parvocellular-biased stimuli and emotion recognition using the Penn Emotion Recognition (ER-40) and Emotion Differentiation (EMODIFF) tests. Experiment 2 altered the contrast levels of the faces themselves to determine whether emotion detection curves would show a pattern characteristic of magnocellular neurons and whether patients would show a deficit in performance related to early sensory processing stages. Results for experiment 1 showed that patients had impaired emotion processing and a preferential magnocellular deficit on the contrast sensitivity task. Greater deficits in ER-40 and EMODIFF performance correlated with impaired contrast sensitivity to the magnocellular-biased condition, which remained significant for the EMODIFF task even when nonspecific correlations due to group were considered in a step-wise regression. Experiment 2 showed contrast response functions indicative of magnocellular processing for both groups, with patients showing impaired performance. Impaired emotion identification on this task was also correlated with magnocellular-biased visual sensory processing dysfunction. These results provide evidence for a contribution of impaired early-stage visual processing in emotion recognition deficits in schizophrenia and suggest that a bottom-up approach to remediation may be effective.
Schizophrenia Research Center, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, USA. butler@nki.rfmh.org
Pamela D
PD
Butler
Ilana Y
IY
Abeles
Nicole G
NG
Weiskopf
Arielle
A
Tambini
Maria
M
Jalbrzikowski
Michael E
ME
Legatt
Vance
V
Zemon
James
J
Loughead
Ruben C
RC
Gur
Daniel C
DC
Javitt
D000328:Adult; D001288:Attention / Q000502:physiology; D015350:Contrast Sensitivity / Q000502:physiology; D003657:Decision Making / Q000502:physiology; D004192:Discrimination, Psychological / Q000502:physiology; D004644:Emotions / Q000502:physiology*; D005149:Facial Expression; D005260:Female; D005829:Geniculate Bodies / Q000503:physiopathology*; D006801:Humans; D008297:Male; D009474:Neurons / Q000502:physiology; D009483:Neuropsychological Tests; D010364:Pattern Recognition, Visual / Q000502:physiology*; D010468:Perceptual Disorders / Q000175:diagnosis / Q000503:physiopathology* / Q000523:psychology; D011601:Psychophysics; D011618:Psychotic Disorders / Q000175:diagnosis / Q000503:physiopathology* / Q000523:psychology; D012559:Schizophrenia / Q000175:diagnosis / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D014793:Visual Cortex / Q000503:physiopathology*; D014795:Visual Pathways / Q000503:physiopathology*