Association between fine particulate matter and oxidative DNA damage may be modified in individuals with hypertension.
OBJECTIVE
To investigate the association between particulate matter (PM2.5) and urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) in hypertensive and non-hypertensive individuals.


METHODS
Twelve hypertensives and nine non-hypertensives were monitored during a 36-hour period using a repeated-measures panel study design. Personal exposure to PM2.5 was assessed using a real-time continuous monitor. Spot urine samples collected at 12-hour intervals were analyzed for 8-OHdG.


RESULTS
Exposure to PM2.5 was associated with a decrease in 8-OHdG in hypertensives compared with an increase in non-hypertensives, after adjusting for age, gender, smoking status, and time of day.


CONCLUSIONS
The results suggest modification of the association between PM2.5 exposure and urinary 8-OHdG by hypertension status. Antioxidant activity present in antihypertensive medications may play a role or PM2.5 exposure may reduce the capacity to repair DNA damage in hypertensives. These results should be confirmed with further investigation.
National Center for Environmental Assessment, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA.
Jee Young
JY
Kim
Lacey A
LA
Prouty
Shona C
SC
Fang
Ema G
EG
Rodrigues
Shannon R
SR
Magari
Geoffrey A
GA
Modest
David C
DC
Christiani
D000080242:8-Hydroxy-2'-Deoxyguanosine; D000328:Adult; D000368:Aged; D000393:Air Pollutants / Q000009:adverse effects* / Q000032:analysis; D016022:Case-Control Studies; D004249:DNA Damage; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000652:urine; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000235:genetics / Q000652:urine; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D052638:Particulate Matter / Q000009:adverse effects* / Q000032:analysis; D055815:Young Adult
D000393:Air Pollutants; D052638:Particulate Matter; D000080242:8-Hydroxy-2'-Deoxyguanosine; D003849:Deoxyguanosine