Genetics of the cervix in relation to preterm birth.
Preterm birth is the most significant problem encountered in obstetrics in the developed world. Genetic factors are thought to play a role in a proportion of preterm births, and candidate genes have been studied in several areas relevant to parturition. Abnormal cervical function, a clinical spectrum, including cervical insufficiency (CI), is a contributing factor to the overall problem of preterm birth. There are many risk factors and etiologies for CI. However, it is becoming clear that, at least in part, a genetic predisposition to CI plays a role in the condition. Specifically, genes related to connective tissue metabolism and inflammation have been shown to be associated with CI.
Warren
Jennifer E
JE
Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, UT 84132, USA.
Silver
Robert M
RM
D002584:Cervix Uteri / Q000502:physiology*; D003238:Connective Tissue / Q000276:immunology / Q000378:metabolism*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D047928:Premature Birth / Q000235:genetics*; D002581:Uterine Cervical Incompetence / Q000235:genetics* / Q000276:immunology / Q000378:metabolism