Antibiotic resistance determinants in Acinetobacter spp and clinical outcomes in patients from a major military treatment facility.
We explored the association of antibiotic-resistant phenotypes and genotypes in Acinetobacter spp with clinical outcomes and characteristics in 75 patients from a major military treatment facility. Amikacin resistance was associated with nosocomial acquisition of A baumannii, and carbapenem resistance and bla(OXA-23) were associated with the need for mechanical ventilation. The presence of bla(OXA-23) also correlated with longer hospital and ICU stay. Associations between bla(OXA-23) and complexity, duration, and changes made to antibiotic regimens also existed.
Division of Infectious Diseases and HIV Medicine, University Hospitals Case Medical Center, Cleveland, OH, USA.
Federico
F
Perez
Andrea M
AM
Hujer
Edward A
EA
Hulten
Joel
J
Fishbain
Kristine M
KM
Hujer
David
D
Aron
Katherine
K
Thweatt
Curtis J
CJ
Donskey
Robert A
RA
Bonomo
D000150:Acinetobacter / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D000151:Acinetobacter Infections / Q000188:drug therapy* / Q000382:microbiology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001426:Bacterial Proteins / Q000096:biosynthesis / Q000235:genetics; D004269:DNA, Bacterial / Q000235:genetics; D024881:Drug Resistance, Bacterial; D005838:Genotype; D006772:Hospitals, Military; D006801:Humans; D007902:Length of Stay; D008826:Microbial Sensitivity Tests; D010641:Phenotype; D012121:Respiration, Artificial; D016896:Treatment Outcome; D001618:beta-Lactamases / Q000096:biosynthesis / Q000235:genetics
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D004269:DNA, Bacterial; C466679:beta-lactamase OXA-23; D001618:beta-Lactamases