Alternative haematopoietic stem cell sources for transplantation: place of umbilical cord blood.
Umbilical cord blood has rapidly become a valuable alternative stem cell source for allogeneic haematopoietic stem cell transplantation. Extensive research over the last 20 years has established the safety and efficacy of umbilical cord blood transplantation in both children and adults with a variety of malignant and non-malignant diseases. This research has clearly shown that this stem cell source has several unique characteristics resulting in distinct advantages and disadvantages when compared to transplantation with unrelated bone marrow or peripheral blood stem cells. This article reviews the most recent literature comparing the outcomes after umbilical cord blood transplantation with other alternative stem cell sources.
Smith
Angela R
AR
Division of Pediatric Hematology/Oncology/Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota Medical School, MMC 484, 420 Delaware Street SE, Minneapolis, MN 55455, USA. smith719@umn.edu
Wagner
John E
JE
D000328:Adult; D002648:Child; D002675:Child, Preschool; D036101:Cord Blood Stem Cell Transplantation / Q000009:adverse effects / Q000379:methods*; D005199:Fanconi Anemia / Q000628:therapy; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods; D006453:Hemoglobinopathies / Q000628:therapy; D006801:Humans; D007223:Infant; D007938:Leukemia / Q000628:therapy; D009894:Opportunistic Infections / Q000209:etiology; D019172:Transplantation Conditioning / Q000379:methods