Syntheses and configuration determination of (+)-villatamines A and B, two marine natural products.
The first total syntheses of (+)-villatamines A and B have been realized in six and five steps, respectively. The stereogenic center present in these two naturally occurring alkaloids should have an (S)-configuration based on our results.
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xue Yuan Rd, Beijing 100083, China.
Lin
L
Hu
Lihe
L
Zhang
Hongbin
H
Zhai
D001685:Biological Factors / Q000138:chemical synthesis* / Q000737:chemistry*; D008968:Molecular Conformation; D011759:Pyrrolidines / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism
D001685:Biological Factors; D011759:Pyrrolidines; C545418:villatamine A; C545417:villatamine B