Ankle-brachial index, a screening for peripheral obstructive arterial disease, and migraine - a controlled study.
BACKGROUND
Epidemiological studies support the association between migraine, especially migraine with aura, and vascular disorders. The ankle-brachial index (ABI) is largely used as a surrogate of peripheral obstructive arterial disorders (POAD). Accordingly, in this study we contrasted the ABI in individuals with migraine and in controls.


METHODS
We investigated 50 migraineurs and 38 controls and obtained the ABI (ratio between the systolic arterial pressure obtained in the legs and in the arms) using digital sphygmomanometry. As per validation studies, we used the cut-off of 0.9 as the normal limit for the ABI. We adjusted for gender, use of contraceptive hormones, tabagism, and other cardiovascular risk factors.


RESULTS
We found abnormal values of ABI, suggestive of mild or moderate POAD, in 31 individuals (35.2%). Mean value was 0.96 (standard deviation = 0.10). None of our patients had ABI < 0.4, which would suggest severe POAD. Mean ABI for migraineurs was 0.94 (0.11), and for controls it was 0.99 (0.09). Difference was significant (t = 2.21 and P = .022). After adjustments, ABI remained significantly associated with migraine status (P = .024). Adjustments were reasonably effective (chi(2) of Hosmer-Lemeshow = 1.06, P = .590).


CONCLUSIONS
Our findings suggest that decreased values of ABI are more common in migraineurs than in controls. Although causality was not assessed by us, the relationship is of importance per se. Doctors should measure the ABI in individuals with migraine as an easy way to screen for cardiovascular risk.
Jurno
Mauro Eduardo
ME
Hospital Regional - FHEMIG - Neurology, Barbacena, Brazil.
Chevtchouk
Liliana
L
Nunes
Aida Aguilar
AA
de Rezende
Dilermando Fazito
DF
Jevoux
Carla da Cunha
Cda C
de Souza
Jano Alves
JA
Moreira Filho
Pedro Ferreira
PF
D000293:Adolescent; D000328:Adult; D000842:Ankle / Q000098:blood supply / Q000502:physiology; D001132:Arm / Q000098:blood supply / Q000502:physiology; D015415:Biomarkers / Q000032:analysis; D001794:Blood Pressure / Q000502:physiology*; D001795:Blood Pressure Determination / Q000295:instrumentation / Q000379:methods; D001916:Brachial Artery / Q000503:physiopathology; D015897:Comorbidity; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D008297:Male; D008403:Mass Screening / Q000379:methods*; D008875:Middle Aged; D008881:Migraine Disorders / Q000175:diagnosis* / Q000453:epidemiology* / Q000503:physiopathology; D016491:Peripheral Vascular Diseases / Q000175:diagnosis* / Q000453:epidemiology* / Q000503:physiopathology; D011237:Predictive Value of Tests; D011379:Prognosis; D018570:Risk Assessment; D012307:Risk Factors; D016909:Tibial Arteries / Q000503:physiopathology; D055815:Young Adult
D015415:Biomarkers