Impaired renal function is associated with mortality in kidney-transplanted patients.
BACKGROUND
To date, only a few, at times conflicting, reports suggested that renal function and mortality are associated in kidney-transplanted patients. In our prevalence cohort study, we tested the hypothesis that renal function is associated with mortality in transplanted patients.


METHODS
Data from 985 transplanted patients were analyzed. Socio-demographic parameters, laboratory data, medical and transplant history, type of immunosuppression and estimated glomerular filtration rate were tabulated at baseline. Data on 5-year outcome were collected prospectively.


RESULTS
In multivariate Cox proportional hazard models, the estimated glomerular filtration rate measured at baseline significantly predicted mortality [hazard ratio (HR)(for each 10 ml/min decrease) = 1.271; 95% confidence interval (CI): 1.121-1.440] after adjustment for several covariables. Additionally, in multivariate Cox proportional hazard models, chronic kidney disease stage 4-5 (HR = 2.678; 95% CI: 1.494-4.802) significantly increased the mortality hazard compared to chronic kidney disease stage 1-2.


CONCLUSIONS
Renal function is significantly and independently associated with mortality over 5 years in kidney-transplanted patients among whom mycophenolate mofetil use was very prevalent.
Remport
Adam
A
Department of Transplantation and Surgery, Semmelweis University, Baross utca 23-25, 1082 Budapest, Hungary.
Molnar
Miklos Zsolt
MZ
Ambrus
Csaba
C
Keszei
Andras
A
Torok
Szilard
S
Vamos
Eszter Panna
EP
Kiss
Istvan
I
Jaray
Jeno
J
Novak
Marta
M
Rosivall
Laszlo
L
Mucsi
Istvan
I
D003404:Creatinine / Q000097:blood; D005260:Female; D005919:Glomerular Filtration Rate; D006084:Graft Rejection; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007668:Kidney / Q000503:physiopathology*; D016030:Kidney Transplantation / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D016019:Survival Analysis; D015996:Survival Rate
D007166:Immunosuppressive Agents; D003404:Creatinine