Antinociceptive activity of lectins from Diocleinae seeds on acetic acid-induced writhing test in mice.
Diocleinae lectins administered per oral route in mice inhibited the abdominal constrictions induced by acetic acid. The percentage of the lectins antinociception varied from 61% for Canavalia grandiflora (ConGf) to 20% for Dioclea violacea. ConGf inhibited contortions at all doses tested but not in a dose-dependent manner, involving carbohydrate recognition.
Holanda
Fernanda R
FR
Instituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará, Av. Paranjana, 1700, 60740-000, Fortaleza, Ceará, Brasil.
Coelho-de-Sousa
Andrelina N
AN
Assreuy
Ana M S
AM
Leal-Cardoso
José Henrique
JH
Pires
Alana F
AF
do Nascimento
Kyria S
KS
Teixeira
Cícero S
CS
Cavada
Benildo S
BS
Santos
Cláudia F
CF
D019342:Acetic Acid; D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D052598:Dioclea / Q000737:chemistry; D005260:Female; D008297:Male; D051379:Mice; D010146:Pain / Q000139:chemically induced; D037121:Plant Lectins / Q000494:pharmacology*; D012639:Seeds / Q000737:chemistry
D000700:Analgesics; D037121:Plant Lectins; D019342:Acetic Acid