Two new acorane sesquiterpenes from Illicium henryi.
Two new acorane sesquiterpenes, 10-hydroxyacoronene (1) and 1beta-isopropyl-4beta-methyl-9beta-hydroxy spiro[4.5]dec-6-en-8-one (2), one new natural product, 4-hydroxy-4, 6-dimethyl-1-tetralone (3), and one known acorane sesquiterpene, acoradiepoxide (4) were isolated from the twigs and leaves of Illicium henryi. The structures of the new compounds were elucidated primarily on the basis of analysis of spectroscopic data. In addition, the inhibitory effect on NO production of these compounds were tested. Compounds 1 and 4 exhibited slight inhibitory effects on NO production with IC50 values of 82.4 microg/mL and 76.5 microg/mL, respectively.
Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China.
Tai-Fa
TF
Song
Wei-Dong
WD
Zhang
Xin-Hua
XH
Xia
Yun-Heng
YH
Shen
Chun-Mei
CM
Liu
Sheng
S
Lin
Hui-zi
HZ
Jin
Hui-Liang
HL
Li
D000818:Animals; D002478:Cells, Cultured; D029523:Illicium / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D009569:Nitric Oxide / Q000096:biosynthesis; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D012717:Sesquiterpenes; D009569:Nitric Oxide