Antibacterial activity of aminoderivatized chitosans against methicillin-resistant Staphylococcus aureus (MRSA).
This work describes the anti-MRSA activity of aminoderivatized chitosans. Two kinds of aminoethyl-chitosans (AEC), AEC90 and AEC50, having degrees of deacetylation of 90% and 50%, respectively, exhibited the strongest anti-MRSA activities by presenting MICs of 16-64 microg/mL against two standard strains and twelve clinical isolates. The bactericidal activity, thermal and pH stability, and cell membrane integrity effects of AEC90 and AEC50 are also discussed.
Department of Microbiology, Pukyong National University, Busan 608-737, Republic of Korea.
Dae-Sung
DS
Lee
Seong-Yun
SY
Jeong
Young-Mog
YM
Kim
Myung-Suk
MS
Lee
Chang-Bum
CB
Ahn
Jae-Young
JY
Je
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002462:Cell Membrane / Q000187:drug effects; D048271:Chitosan / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects*; D008826:Microbial Sensitivity Tests
D000900:Anti-Bacterial Agents; D048271:Chitosan