T cells, dendritic cells and epithelial cells in intestinal homeostasis.
The mucosal immune system of the intestinal tract is continuously exposed to both potential pathogens and beneficial commensal microorganism. A variety of mechanisms contribute to the ability of the gut to either react or remain tolerant to antigen present in the intestinal lumen. Antigens of the gut commensals are not simply ignored, but rather trigger an active immunosuppressive process, which prevents the outcome of immunopathology. The aim of this review is to provide an update on the mechanism of intestinal homeostasis, with particular focus on the complex crosstalk between T cells, dendritic cells and intestinal epithelial cells.
Westendorf
Astrid M
AM
Institute of Medical Microbiology, University Hospital Essen, Hufelandstrasse 55, D-45122 Essen, Germany. Astrid.Westendorf@uk-essen.de
Fleissner
Diana
D
Hansen
Wiebke
W
Buer
Jan
J
D003713:Dendritic Cells / Q000276:immunology*; D004847:Epithelial Cells / Q000502:physiology*; D006706:Homeostasis; D006801:Humans; D007413:Intestinal Mucosa / Q000502:physiology*; D013601:T-Lymphocytes / Q000276:immunology*