Mucosal lesions may be a minor complication of SAPHO syndrome: a study of 11 Japanese patients with SAPHO syndrome.
Since the term synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome was proposed by Chamot et al. (Rev Rhum Mal Osteoartic 54:187-196, 1987), clinical reviews concerning this syndrome have been mainly reported from Europe. We carried out a retrospective analysis of 11 Japanese patients with SAPHO syndrome, and reviewed the clinical features of our series in comparison with those in a European large case study. In this study the major features of SAPHO syndrome were chronic osteitis of the anterior chest wall and pustulotic arthro-ostitis with middle age onset, and mucosal lesions seemed to be a minor complication of SAPHO syndrome. The non-erosive peripheral large joints arthritis and the particular HLA types (HLA-B51, B52, or A26), which had been reported to be increased in Behcet's disease, were frequently seen in SAPHO syndrome with mucosal lesions. This study also suggests that SAPHO syndrome with mucosal lesions may be part of a broader disease spectrum including Behcet's disease.
Department of Orthopaedic Surgery, Kawasaki Municipal Ida Hospital, Ida 2-27-1, Nakahara-ku, Kawasaki City, 211-0035, Japan. yabehiroki@nyc.odn.ne.jp
Hiroki
H
Yabe
Hisaji
H
Ohshima
Yoji
Y
Takano
Takahiro
T
Koyanagi
Hiroshi
H
Usui
Kenya
K
Nojiri
Kensuke
K
Ochi
Michiya
M
Kihara
Yukio
Y
Horiuchi
D020083:Acquired Hyperostosis Syndrome / Q000188:drug therapy / Q000453:epidemiology / Q000473:pathology*; D000328:Adult; D017668:Age of Onset; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D044466:Asian People / Q000208:ethnology; D002908:Chronic Disease; D004359:Drug Therapy, Combination; D005260:Female; D006680:HLA Antigens / Q000097:blood; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D010000:Osteitis / Q000188:drug therapy / Q000453:epidemiology / Q000473:pathology*; D011239:Prednisolone / Q000627:therapeutic use; D012189:Retrospective Studies; D013281:Stomatitis, Aphthous / Q000188:drug therapy / Q000453:epidemiology / Q000473:pathology*; D044465:White People / Q000208:ethnology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D006680:HLA Antigens; D011239:Prednisolone