Lox-1: the multifunctional receptor underlying cardiovascular dysfunction.
Oxidatively modified low-density lipoprotein (oxLDL) is implicated in the pathogenesis of atherosclerosis. Endothelial dysfunction is the initial change in the vascular wall that induces morphological changes for atheroma-formation. Lectin-like oxidized LDL receptor-1 (LOX-1) was identified as the receptor for oxLDL that was thought to be a major cause of endothelial dysfunction. LOX-1 has been demonstrated to contribute not only to endothelial dysfunction, but also to atherosclerotic-plaque formation, myocardial infarction and intimal thickening after balloon injury. Recent findings on the genetics of LOX-1 and the methodology to detect it and its ligands would further facilitate the examination of the receptor's pathophysiological contribution in atherosclerosis. Furthermore, LOX-1-related tools might open new gateways from diagnosis to therapeutics for cardiovascular diseases.
Department of Vascular Physiology, National Cardiovascular Center, Suita, Japan.
Sayoko
S
Ogura
Akemi
A
Kakino
Yuko
Y
Sato
Yoshiko
Y
Fujita
Shin
S
Iwamoto
Kazunori
K
Otsui
Ryo
R
Yoshimoto
Tatsuya
T
Sawamura
D000818:Animals; D002097:C-Reactive Protein / Q000502:physiology; D002318:Cardiovascular Diseases / Q000209:etiology / Q000235:genetics / Q000503:physiopathology*; D006801:Humans; D007668:Kidney / Q000293:injuries / Q000503:physiopathology; D008024:Ligands; D008955:Models, Cardiovascular; D008958:Models, Molecular; D009203:Myocardial Infarction / Q000503:physiopathology; D051127:Scavenger Receptors, Class E / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D015398:Signal Transduction
D008024:Ligands; C495137:OLR1 protein, human; D051127:Scavenger Receptors, Class E; D002097:C-Reactive Protein