Bioactivity of flavonoids isolated from Lychnophora markgravii against Leishmania amazonensis amastigotes.
The bioactivity of the flavonoids pinostrobin (1), pinocembrin (2), tectochrysin (3), galangin 3-methyl ether (4), and tiliroside (5) isolated from Lychnophora markgravii aerial parts was investigated in vitro against amastigote stages of Leishmania amazonensis. The compounds were isolated by several chromatographic techniques and their chemical structures were established by ESI-MS and NMR spectroscopic data. The flavonoids 1 and 3 were the most active compounds; they markedly reduced the viability of Leishmania amastigotes.
Curso de Farmácia, Instituto de Biologia, Departamento de Biologia Vegetal, Universidade Estadual de Campinas (UNICAMP), Caixa Postal 6109, CEP 13083-970, Campinas (SP), Brazil. mjsalvador@bol.com.br
Marcos José
MJ
Salvador
Fabiana Terezinha
FT
Sartori
Ana Claudia B C
AC
Sacilotto
Elizabeth M F
EM
Pral
Silvia Celina
SC
Alfieri
Walter
W
Vichnewski
D000666:Amphotericin B / Q000494:pharmacology; D000818:Animals; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000494:pharmacology*; D019659:Asteraceae / Q000737:chemistry*; D044950:Flavanones / Q000737:chemistry; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D007891:Leishmania / Q000187:drug effects*; D008958:Models, Molecular
D000981:Antiprotozoal Agents; D044950:Flavanones; D005419:Flavonoids; C052083:tiliroside; D000666:Amphotericin B; C016063:pinocembrin; C411294:pinostrobin