[Effect of sulpiride on immobility reflex and pinch-induced catalepsy in CBA/Lac male mice with various social status].
This study was aimed to determine the effect of D2/D3 receptor antagonist sulpiride on the expression of immobility reflex ("pinch-test") and pinch-induced catalepsy ("bar-test") of CBA/Lac male mice depending on their social status ("aggressors" with repeated experience of victories or a "losers" with repeated experience of social defeats). Sulpiride (20 mg/kg, i.p.) was acutely administered to "aggressors" and "losers" after 10 and 20 daily social contacts (victories or social defeats) and to a control group of male mice. Repeated experience of social victories and defeats altered the immobility duration in both tests and modified the expression of the sulpiride effect. In the pinch-tets, the duration of immobility was longer in "loosers" than in "aggressors". In the bar-test, the pinch-induced catalepsy was more expressed in "losers" and "aggressors" as compared to control. Sulpiride was more effective in increasing immobility of"aggressors" and had a weaker effect on the control and "losers". Therefore, the effect of sulpiride is affected by the social status of the animals.
Lipina
T V
TV
Vishnivetskaia
G B
GB
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology*; D002375:Catalepsy / Q000503:physiopathology*; D004291:Dominance-Subordination; D018492:Dopamine Antagonists / Q000494:pharmacology*; D008297:Male; D051379:Mice; D012919:Social Behavior; D013469:Sulpiride / Q000494:pharmacology*
D018492:Dopamine Antagonists; D013469:Sulpiride