Enhancement of guided-wave two-photon-excited luminescence response with a photonic-crystal fiber.
Photonic-crystal fiber (PCF) is shown to substantially increase the guided-wave luminescent response from molecules excited through two-photon absorption (TPA) by femtosecond near-infrared laser pulses. With only a few nanoliters of TPA-excited molecules filling airholes in a specifically designed PCF, the guided-wave two-photon-excited luminescence (TPL) signal is enhanced by more than 2 orders of magnitude relative to the maximum TPL signal attainable from a cell with the same dye excited and collected by the same PCF. Biophotonic implications of this waveguide TPL-response enhancement include fiber-format solutions for online monitoring of drug delivery and drug activation, interrogation of neural activity, biosensing, endoscopy, and locally controlled singlet oxygen generation in photodynamic therapy.
Physics Department, International Laser Center, M. V. Lomonosov Moscow State University, Vorob'evy gory, Moscow 119992, Russia.
Ilya V
IV
Fedotov
Andrei B
AB
Fedotov
Lyubov V
LV
Doronina
Aleksei M
AM
Zheltikov
D017076:Computer-Aided Design; D003460:Crystallization / Q000379:methods; D004867:Equipment Design; D019544:Equipment Failure Analysis; D008029:Lighting / Q000295:instrumentation*; D008163:Luminescent Measurements / Q000295:instrumentation*; D055100:Optical Fibers; D017785:Photons; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity