Prophylactic use of antibiotic-loaded bone cement in primary total knee replacement.
Despite significant advances in intraoperative antimicrobial procedures, deep infection remains the most devastating complication following total joint arthroplasty. Clinical studies' results and safety profile of antibiotic-loaded bone cement are discussed in this review. Antibiotic bone cement prophylaxis is a safe and effective strategy in reducing the risk of deep infection following primary total joint arthroplasty.
Randelli
Pietro
P
Dipartimento di Scienze Medico-Chirurgiche, Università degli Studi di Milano, Policlinico San Donato IRCCS, Via Morandi 30, San Donato Milanese, 20097, Milan, Italy. pietro.randelli@tin.it
Evola
Francesco R
FR
Cabitza
Paolo
P
Polli
Luca
L
Denti
Matteo
M
Vaienti
Luca
L
D019072:Antibiotic Prophylaxis; D019645:Arthroplasty, Replacement, Knee; D001843:Bone Cements / Q000737:chemistry / Q000627:therapeutic use*; D004337:Drug Carriers / Q000627:therapeutic use; D005060:Europe; D006801:Humans; D016459:Prosthesis-Related Infections / Q000517:prevention & control*
D001843:Bone Cements; D004337:Drug Carriers