Telmisartan: from lowering blood pressure to end-organ protection.
The principal aim in the treatment of patients with high blood pressure is to ensure a maximum reduction in the total risk of cardiovascular morbidity and mortality. The renin-angiotensin system plays an important role in volume homeostasis and blood pressure regulation. The angiotensin receptor blockers control high blood pressure by preventing the binding of angiotensin II to the subtype 1 receptor, which is believed to mediate most of the physiologic actions of angiotensin II relevant to the regulation of blood pressure. Telmisartan is a widely used angiotensin receptor blocker with distinct pharmacokinetic and pharmacodynamic properties. Due to its long duration of action, it compares favorably with other angiotensin receptor blockers. Latest data from clinical trials and newest research regarding telmisartan will be reviewed in this article.
Unger
Thomas
T
Charité - University Medicine Berlin, , Center for Cardiovascular Research (CCR)/Institute of Pharmacology and Toxicology Hessische Strasse 3-4, 10115 Berlin, Germany. Thomas.Unger@charite.de
Schupp
Michael
M