Efficient synthesis of nevirapine analogs to study its metabolic profile by click fishing.
Knowledge of the biotransformation and pharmacokinetics of the antiretroviral agent nevirapine is still insufficient. In order to trace rash inducing metabolites of nevirapine, we devised a short and efficient multi-gram synthesis of a nevirapine analog that can be coupled to azide containing compounds by click chemistry.
Département de Chimie, Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, 3001 12e Avenue nord, Sherbrooke, Québec, Canada J1H 5N4.
Sylvain
S
Bernard
Daniel
D
Defoy
Yves L
YL
Dory
Klaus
K
Klarskov
D000818:Animals; D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D018360:Crystallography, X-Ray; D003500:Cyclization; D006801:Humans; D008968:Molecular Conformation; D019829:Nevirapine / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D051381:Rats
D019380:Anti-HIV Agents; D019829:Nevirapine