Association between preoperative anxiety in spinal stenosis patients and abnormal cerebral glucose metabolism: voxel-based statistical analysis of F-18 FDG brain PET.
Although a possible association between preoperative anxiety and abnormal cerebral glucose metabolism may exist, the authors are not aware of any report describing preoperative anxiety and cerebral metabolism in patients with spinal stenosis in detail. Fluorine-18 fluorodeoxyglucose positron emission tomography with statistical parametric mapping analysis was used to compare regional brain glucose metabolism between 34 spinal stenosis patients and 34 healthy comparison subjects. Spinal stenosis patients with preoperative anxiety showed several voxel clusters of significantly decreased cerebral metabolism. The largest clusters were areas of left insula and left prefrontal cortex (Brodmann's areas 9 and 11). The second largest cluster area was left prefrontal cortex (Brodmann's area 10). The other clusters were right insula (Brodmann's area 13), right superior temporal gyrus (Brodmann's area 22), and right middle frontal gyrus (Brodmann's area 8).
Kim
Seong-Jang
SJ
Department of Nuclear Medicine at Medical Research Institute, Pusan National University School of Medicine, Pusan, Korea.
Suh
Kuen Tak
KT
Cho
He Myung
HM
Kim
In-Ju
IJ
Lee
Jung Sub
JS
D000328:Adult; D000368:Aged; D001007:Anxiety / Q000378:metabolism*; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism*; D001931:Brain Mapping; D005260:Female; D019788:Fluorodeoxyglucose F18; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D057234:Preoperative Period; D011569:Psychiatric Status Rating Scales; D013130:Spinal Stenosis / Q000378:metabolism* / Q000523:psychology / Q000601:surgery*
D019788:Fluorodeoxyglucose F18; D005947:Glucose