Mastering the chemical language of bacteria.
The publication of the crystal structures of a bacterial quorum sensing receptor complexed with a variety of ligands (Zou and Nair, 2009) provides a much-needed molecular rationale for the modulation of this intercellular signaling process, which may facilitate the development of new therapeutic agents.
Galloway
Warren R J D
WR
Department of Chemistry, University of Cambridge, Cambridge, UK.
Hodgkinson
James T
JT
Welch
Martin
M
Spring
David R
DR
D015107:4-Butyrolactone / Q000031:analogs & derivatives / Q000494:pharmacology; D001426:Bacterial Proteins / Q000737:chemistry* / Q000378:metabolism; D018360:Crystallography, X-Ray; D011485:Protein Binding; D011550:Pseudomonas aeruginosa / Q000378:metabolism*; D053038:Quorum Sensing / Q000502:physiology*; D054852:Small Molecule Libraries; D013730:Terphenyl Compounds / Q000737:chemistry / Q000494:pharmacology*; D015534:Trans-Activators / Q000737:chemistry* / Q000378:metabolism
D001426:Bacterial Proteins; C080365:LasR protein, Pseudomonas aeruginosa; D054852:Small Molecule Libraries; D013730:Terphenyl Compounds; D015534:Trans-Activators; C088386:homoserine lactone; D015107:4-Butyrolactone