Longitudinal assessment of antimüllerian hormone during pregnancy-relationship with maternal adiposity, insulin, and adiponectin.
We examined in a prospective longitudinal pregnancy cohort the influence of advancing gestation and baseline maternal adiposity on antimüllerian hormone (AMH) and determined whether maternal hormones (insulin, leptin, adiponectin, E(2), and sex hormone-binding globulin) correlate with alterations in AMH. We demonstrate that first-trimester AMH is associated negatively with maternal adiposity, that circulating levels decline during the second and third trimesters of pregnancy, and that in univariate and multivariate models adiponectin is associated positively with AMH during this period of pregnancy-related decline.
Reproductive and Maternal Medicine, University of Glasgow, Glasgow Royal Infirmary, 10 Alexandra Parade, Glasgow, G31 2ER, United Kingdom. s.nelson@clinmed.gla.ac.uk
Scott M
SM
Nelson
Frances
F
Stewart
Richard
R
Fleming
Dilys J
DJ
Freeman
D052242:Adiponectin / Q000097:blood*; D050154:Adiposity / Q000502:physiology*; D054304:Anti-Mullerian Hormone / Q000097:blood*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance / Q000502:physiology; D008137:Longitudinal Studies; D008429:Maternal Welfare / Q000639:trends; D011247:Pregnancy; D011446:Prospective Studies
D052242:Adiponectin; D007328:Insulin; D054304:Anti-Mullerian Hormone