Residual goiter in Semirom; iodine status and thiocyanate overload do not play a role.
This study was performed to investigate the role of thiocyanate overload in the etiology of endemic goiter in schoolchildren of Semirom, Iran. A total of 1828 schoolchildren were selected by multi-stage random sampling. Urinary iodine concentration (UIC) and urinary thiocyanate (USCN) were measured in a group of these children. The median UIC was 18.5 microg/dl. The mean +/- SD of USCN in goitrous and nongoitrous subjects did not differ significantly (0.75 +/- 0.78 mg/dl vs. 0.63 +/- 0.40 mg/dl; p = 0.30). Finally, we concluded that neither iodine deficiency nor thiocyanate overload contributed to the high prevalence of goiter in Semirom. The role of other goitrogenic factors should be investigated in this region.
Ammar Hassanzadeh
AH
Keshteli
Mahin
M
Hashemipour
Masoud
M
Amini
Mansour
M
Siavash
Ashraf
A
Aminorroaya
Hassan
H
Rezvanian
Ali
A
Kachuei
Roya
R
Kelishadi
D000293:Adolescent; D002648:Child; D005260:Female; D006043:Goiter, Endemic / Q000453:epidemiology / Q000209:etiology*; D006801:Humans; D007455:Iodine / Q000172:deficiency* / Q000652:urine; D007492:Iran / Q000453:epidemiology; D008297:Male; D015995:Prevalence; D013861:Thiocyanates / Q000652:urine*
D013861:Thiocyanates; D007455:Iodine; C031760:thiocyanate