The frequency of self-reported allergic diseases in patients with crimean-congo haemorrhagic fever.
BACKGROUND
Crimean-Congo haemorrhagic fever (CCHF) is an acute, tick-borne viral disease. In temperate areas, CCHF cases occur between spring and early autumn when tick activity is high. This period is also the pollen season during which symptoms of allergic diseases are exacerbated. Viruses induce inflammatory and antiviral responses by binding to specific receptors on the surface of airway epithelial cells, resulting in activation of innate immune responses; release of mediators such as cytokines and chemokines; and recruitment of neutrophils and mononuclear cells to the area.


OBJECTIVE
We aimed to evaluate the frequency of self-reported allergic diseases and the effect on CCHF severity.


METHODS
Between June and August 2008, a questionnaire was applied to 114 CCHF (+) patients and 122 healthy control subjects, 16 to 88 years old who attended the Infectious Diseases clinic and were hospitalised with CCHF suspected, by face to face interview including history of allergic rhinitis (AR), asthma symptoms and nonspecific bronchial reactivity, doctor diagnosed AR and/or asthma, and familial allergic diseases history.


RESULTS
According to PCR and/or enzyme-linked immunoassay (ELISA) results, 51.7% of patients (n=114) had CCHF. There was no significant relation between CCHF and history of AR, asthma symptoms and nonspecific bronchial reactivity, doctor diagnosed AR and/or asthma, and familial allergic diseases history. The severity of CCHF has not affected these parameters (p>.05). Of patients with positive CCHF test, 2.6% (n=3) and 3.5% (n=4) had doctor diagnosed AR and asthma, respectively.


CONCLUSIONS
Self-reported allergic diseases and CCHF are not related with each other.
Cumhuriyet University, Faculty of Medicine, Chest Diseases Dept., Allergic Diseases Subdept., Sivas, Turkey. oabadoglu@cumhuriyet.edu.tr
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D000293:Adolescent; D000328:Adult; D000368:Aged; D002465:Cell Movement; D016207:Cytokines / Q000378:metabolism; D005260:Female; D003225:Hemorrhagic Fever Virus, Crimean-Congo / Q000276:immunology* / Q000472:pathogenicity; D006479:Hemorrhagic Fever, Crimean / Q000150:complications / Q000453:epidemiology / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D007113:Immunity, Innate; D007963:Leukocytes, Mononuclear / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000378:metabolism / Q000473:pathology; D015995:Prevalence; D020545:Respiratory Mucosa / Q000276:immunology / Q000378:metabolism* / Q000473:pathology / Q000821:virology; D006255:Rhinitis, Allergic, Seasonal / Q000150:complications / Q000453:epidemiology / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology; D012621:Seasons; D012650:Self Disclosure; D011795:Surveys and Questionnaires; D053585:Virus Attachment
D016207:Cytokines