[Effect of apelin in cardiovascular system and water metabolism].
Apelin is a recently identified peptide which plays an important role in cardiovascular function and in water metabolism. Apelin and its receptor APJ (apelin system) are involved in zebra fish and xenopus cardiovascular development. Apelin is a pro-angiogenic factor. Apelin is a potent cardiac inotropic agent and exerts a vasodilatory effect in arterial and venous territories. Apelin decreases vasopressin production and its plasma level is conversely related to plasma vasopressin. Several effects of the apelin system counteract those of the renin angiotensin system. It may represent a new and promising therapeutic opportunity for the treatment of cardiovascular diseases.
Corvol
Pierre
P
Inserm U833, Collège de France, 11 place Marcelin Berthelot, 75005 Paris, France. pierre.corvol@college-de-france.fr
D000818:Animals; D000073861:Apelin; D000075244:Apelin Receptors; D050197:Atherosclerosis / Q000188:drug therapy; D002320:Cardiovascular Physiological Phenomena / Q000187:drug effects; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics / Q000378:metabolism / Q000494:pharmacology / Q000502:physiology*; D018919:Neovascularization, Physiologic / Q000502:physiology; D043562:Receptors, G-Protein-Coupled / Q000096:biosynthesis / Q000235:genetics; D012084:Renin-Angiotensin System / Q000187:drug effects / Q000502:physiology; D014018:Tissue Distribution; D014667:Vasopressins / Q000096:biosynthesis; D014867:Water / Q000378:metabolism*
C115436:APLN protein, human; C104575:APLNR protein, human; D000073861:Apelin; D000075244:Apelin Receptors; D036341:Intercellular Signaling Peptides and Proteins; D043562:Receptors, G-Protein-Coupled; D014867:Water; D014667:Vasopressins