Disease progression in HIV-1-infected patients heterozygous for the sickle hemoglobin gene.
The sickle cell trait-asymptomatic carriage is frequent in people originating from sub-Saharan Africa. Several host factors (including sickle cell anemia) have been previously reported to act upon the course of HIV disease. We studied the progression of infection in a cohort of African patients heterozygous for the sickle hemoglobin gene and harboring normal hemoglobin genes. No significant difference was evidenced between the two groups from this preliminary study.
Department of Internal Medicine and Infectious Diseases, Lariboisière Hospital, Paris, France.
Pierre
P
Sellier
Elisabeth
E
Masson
Jean-M
JM
Zini
Guy
G
Simoneau
Jean-D
JD
Magnier
John
J
Evans
Jean-F
JF
Bergmann
D000328:Adult; D017954:Africa South of the Sahara / Q000453:epidemiology; D000755:Anemia, Sickle Cell / Q000453:epidemiology / Q000235:genetics*; D018450:Disease Progression; D005260:Female; D015497:HIV-1; D006451:Hemoglobin, Sickle / Q000235:genetics*; D006579:Heterozygote; D006801:Humans; D008297:Male
D006451:Hemoglobin, Sickle