Facile synthesis of 1,2,4-triazoles via a copper-catalyzed tandem addition-oxidative cyclization.
A simple one-step synthesis of 1,2,4-triazole derivatives is provided by a copper-catalyzed oxidative coupling reaction under an atmosphere of air. The process should consist of sequential N-C and N-N bond-forming copper-catalyzed oxidative coupling reactions. Starting materials and the copper catalyst are readily available and inexpensive. A wide range of functional groups are tolerated to achieve chemical diversity.
Ueda
Satoshi
S
Laboratory of Medicinal and Pharmaceutical Chemistry, Gifu Pharmaceutical University, 5-6-1 Mitahora-higashi, Gifu 502-8585, Japan.
Nagasawa
Hideko
H
D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D015394:Molecular Structure; D010084:Oxidation-Reduction; D014230:Triazoles / Q000138:chemical synthesis*
D014230:Triazoles; C045575:1,2,4-triazole; D003300:Copper