Eucalmaidins A-E, (+)-oleuropeic acid derivatives from the fresh leaves of Eucalyptus maideni.
Five new (+)-oleuropeic acid derivatives, eucalmaidins A-E (1-5), together with 12 known compounds (6-17), were isolated from the fresh leaves of Eucalyptus maideni. Structures of the new compounds were determined on the basis of spectroscopic analyses (HSQC, HMBC, and (1)H-(1)H COSY), chemical degradation, and enzymatic hydrolysis. Of the tested compounds, only quercetin showed slight anti-herpes simplex virus 1 (HSV-1) activity in vitro.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, People's Republic of China.
Li-Wen
LW
Tian
Ying-Jun
YJ
Zhang
Yi-Fei
YF
Wang
Chi-Choi
CC
Lai
Chong-Ren
CR
Yang
D000818:Animals; D002522:Chlorocebus aethiops; D003509:Cyclohexanecarboxylic Acids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D003603:Cytotoxins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005052:Eucalyptus / Q000737:chemistry*; D018259:Herpesvirus 1, Human / Q000187:drug effects; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D011794:Quercetin / Q000494:pharmacology; D013237:Stereoisomerism
D003509:Cyclohexanecarboxylic Acids; D003603:Cytotoxins; D004365:Drugs, Chinese Herbal; C417926:oleuropeic acid; D011794:Quercetin