Solid-state interactions of calixarenes with biorelevant molecules.
Among all crystalline complexes of calix-type calix[n]arenes those with organic molecules which are biologically relevant are especially of interest due to their potential medical and pharmaceutical applications. The co-crystallization of drugs with water-soluble calixarenes offers the opportunity to modify chemical and physical properties of APIs (active pharmaceutical ingredients) and to control drug conformation. Such co-crystallization can improve solubility, bioavailability and stability of pharmaceutically active molecules and/or eliminate polymorphism. In this article the solid-state interactions between calixarene hosts and biologically relevant guest molecules are summarized for the currently available structures solved by single-crystal X-ray crystallography.
Institute of Physical Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, PL-01 224 Warszawa, Poland.
Oksana
O
Danylyuk
Kinga
K
Suwinska
D000588:Amines / Q000737:chemistry; D000596:Amino Acids / Q000737:chemistry; D047250:Calixarenes / Q000737:chemistry*; D002264:Carboxylic Acids / Q000737:chemistry; D018360:Crystallography, X-Ray; D008968:Molecular Conformation; D004364:Pharmaceutical Preparations / Q000737:chemistry; D012995:Solubility
D000588:Amines; D000596:Amino Acids; D002264:Carboxylic Acids; D004364:Pharmaceutical Preparations; D047250:Calixarenes