[The creation of tests for the estimation of the biological consequences of X-ray radiation at low doses and changing dose rate on animals].
The dependence of "biological effect-dose" in experiments on mature outbreed mice (females) is studied during 30 days after low intensity X-ray action at the total dose less than 1 mGy. The index (relative mass) of the murine spleen was decreased in the group of mice which have the low value of the spleen index in the control. It is shown that the value of these parameters in groups of irradiated mice is mainly due to the total X-ray doses. The content of the lipid peroxidation products and the amount of the extracellular DNA in blood plasma of the irradiated mice are mainly determined by the change of dose rate during irradiation. The absence of linear interrelation between changes of all studied parameters and the total radiation dose is revealed. The data obtained allow us to suggest the relative mass of the murine spleen, the content of the lipid peroxidation products and the amount of the extracellular DNA as a test for estimation of the biological consequences of X-ray radiation at low doses and changing dose rate.
A M
AM
Klimovich
M A
MA
Smotriaeva
V D
VD
Gaintseva
L N
LN
Shishkina
D000818:Animals; D015415:Biomarkers / Q000097:blood; D004247:DNA / Q000097:blood / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D005260:Female; D050356:Lipid Metabolism / Q000528:radiation effects; D008055:Lipids / Q000097:blood; D051379:Mice; D009929:Organ Size / Q000528:radiation effects; D011833:Radiation Injuries, Experimental / Q000097:blood* / Q000473:pathology; D013154:Spleen / Q000473:pathology / Q000528:radiation effects*; D014916:Whole-Body Irradiation; D014965:X-Rays / Q000009:adverse effects*
D015415:Biomarkers; D008055:Lipids; D004247:DNA