Vitamin B(12) and redox homeostasis: cob(II)alamin reacts with superoxide at rates approaching superoxide dismutase (SOD).
We report a kinetic study of the reaction between superoxide and an important intracellular form of vitamin B(12), cob(II)alamin. Superoxide is implicated in the pathophysiology of many inflammatory diseases, whereas vitamin B(12) derivatives are often beneficial in their treatment. We found that cob(II)alamin reacts with superoxide at rates approaching those of superoxide dismutase itself, suggesting a probable mechanism by which vitamin B(12) protects against chronic inflammation and modulates redox homeostasis.
Suarez-Moreira
Edward
E
Department of Chemistry, School of Biomedical Sciences, Kent State University, Kent, Ohio 44242, USA.
Yun
June
J
Birch
Catherine S
CS
Williams
John H H
JH
McCaddon
Andrew
A
Brasch
Nicola E
NE
D002478:Cells, Cultured; D006706:Homeostasis; D006801:Humans; D007700:Kinetics; D010084:Oxidation-Reduction; D013482:Superoxide Dismutase / Q000378:metabolism*; D013481:Superoxides / Q000737:chemistry / Q000378:metabolism*; D014805:Vitamin B 12 / Q000737:chemistry / Q000378:metabolism*
D013481:Superoxides; D013482:Superoxide Dismutase; D014805:Vitamin B 12