Target pattern recognition by complement proteins of the classical and alternative pathways.
The complement system is a major component of the innate defence of animals against invading microorganisms, and is also essential for the recognition and clearance of damaged or structurally-altered host cells or macromolecules. The system is activated by three different pathways, each of which responds, using different recognition molecules, to a very wide range of activators. The recognition protein of the complement classical pathway, C1q is described in detail here, with comparisons to the alternative pathway.
Kang
Yu-Hoi
YH
MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, Oxford, UK.
Tan
Lee Aun
LA
Carroll
Maria V
MV
Gentle
Madeleine E
ME
Sim
Robert B
RB
D000595:Amino Acid Sequence; D000818:Animals; D017209:Apoptosis / Q000276:immunology; D015922:Complement C1q / Q000276:immunology* / Q000378:metabolism; D003170:Complement Pathway, Alternative / Q000276:immunology*; D003171:Complement Pathway, Classical / Q000276:immunology*; D006801:Humans; D007136:Immunoglobulins / Q000276:immunology / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000737:chemistry / Q000276:immunology* / Q000378:metabolism; D008969:Molecular Sequence Data; D011414:Properdin / Q000276:immunology* / Q000378:metabolism; D011951:Receptors, Complement / Q000737:chemistry / Q000276:immunology* / Q000378:metabolism
D007136:Immunoglobulins; D008562:Membrane Glycoproteins; D011951:Receptors, Complement; C032402:complement 1q receptor; D011414:Properdin; D015922:Complement C1q