Inhibition of the exo-beta-D-glucosaminidase CsxA by a glucosamine-configured castanospermine and an amino-australine analogue.
The synthesis of amino-derivatives of castanospermine and australine and their characterisation as inhibitors of the exo-beta-D-glucosaminidase CsxA through enzyme kinetics and X-ray structural analysis is described.
Pluvinage
Benjamin
B
Biochemistry and Microbiology, University of Victoria, PO Box 3055 STN CSC, Victoria, BC, Canada V8W 3P6.
Ghinet
Mariana G
MG
Brzezinski
Ryszard
R
Boraston
Alisdair B
AB
Stubbs
Keith A
KA
D000192:Actinomycetales / Q000201:enzymology; D000588:Amines / Q000737:chemistry*; D055162:Biocatalysis; D020134:Catalytic Domain; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D005944:Glucosamine / Q000737:chemistry*; D006596:Hexosaminidases / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism; D007212:Indolizines / Q000737:chemistry / Q000494:pharmacology*; D008958:Models, Molecular; D011763:Pyrrolizidine Alkaloids / Q000737:chemistry / Q000494:pharmacology*; D054836:Indolizidines
D000588:Amines; D004791:Enzyme Inhibitors; D005944:Glucosamine; D006596:Hexosaminidases; D007212:Indolizines; D011763:Pyrrolizidine Alkaloids; C059794:australine; C064499:exo-beta-D-glucosaminidase; C037806:castanospermine; D054836:Indolizidines