Embryonic vs. adult myogenesis: challenging the 'regeneration recapitulates development' paradigm.
A popular theory in the stem cell field is that 'regeneration recapitulates development', or that adult stem cells function similarly to embryonic ones. In a recent Nature article, Lepper et al. questioned this approach, highlighting the differences in requirements for Pax7 during myogenesis for embryonic, juvenile and adult muscle.
Wang
John
J
Department of Bioengineering, University of California, Berkeley, 174 Stanley Hall, Berkeley, CA 94720-1762, USA.
Conboy
Irina
I
D000818:Animals; D005260:Female; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D024510:Muscle Development; D018482:Muscle, Skeletal / Q000196:embryology* / Q000254:growth & development* / Q000378:metabolism / Q000502:physiology; D051763:PAX7 Transcription Factor / Q000235:genetics / Q000378:metabolism; D012038:Regeneration; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism
D051763:PAX7 Transcription Factor