The topical delivery of benzoyl peroxide using elegant dynamic hydrofluoroalkane foams.
Formulating benzoyl peroxide (BPO) in an effective topical product is challenging due to its poor water solubility and chemical instability, but delivering BPO using elegant foams is an attractive solution to this problem. The aim of this work was to investigate how nanoparticle properties influence BPO release and permeation when administrated using dynamic hydrofluoroalkane foams. Lipid (LN, approximately 50 nm) and polymeric (PN, approximately 350 nm) nanoparticles were produced and loaded into topical foams. Drug release and permeation was measured using ultrafiltration and Franz cells studies, respectively. No BPO release was detected when the nanoparticles were stored in the aqueous solvent, but upon administration to silicone membrane the pluronic surfactant-induced LN swelling and BPO delivery (35.7 +/- 3.8 microg cm(-2) h(-1)). In the same situation the PN aggregated with a delivery rate of 2.5 +/- 0.2 microg cm(-2) h(-1). Surprisingly the aqueous nanosuspensions delivered BPO at an equivalent rate to the foams despite the poor drug solubility in the dispersing medium presumably due to ultra-rapid BPO solubilization kinetics of the drug in water. The delivery of BPO from the foams (0.1% BPO) was superior compared to the commercial products (5% BPO), but further testing in human skin is required prior to clinical use.
Pharmaceutical Science Division, King's College London, 150 Stamford Street, London SE1 9NH, UK.
Yanjun
Y
Zhao
Marc B
MB
Brown
Stuart A
SA
Jones
D000287:Administration, Topical; D001585:Benzoyl Peroxide / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D002626:Chemistry, Pharmaceutical / Q000379:methods; D004337:Drug Carriers / Q000008:administration & dosage / Q000138:chemical synthesis / Q000737:chemistry*; D006845:Hydrocarbons, Fluorinated / Q000008:administration & dosage / Q000737:chemistry*; D008055:Lipids / Q000737:chemistry; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry*; D010316:Particle Size; D011108:Polymers / Q000737:chemistry; D012995:Solubility; D013535:Suspensions / Q000138:chemical synthesis / Q000737:chemistry; D005466:Fluorocarbons
D001585:Benzoyl Peroxide; D004337:Drug Carriers; D006845:Hydrocarbons, Fluorinated; D008055:Lipids; D011108:Polymers; D013535:Suspensions; C094049:apaflurane; D005466:Fluorocarbons