Synthesis of polysubstituted tetrahydrofurans via Pd-catalyzed carboetherification reactions.
Pd-catalyzed carboetherifications of 1-, 2-, or 3-substituted γ-hydroxy internal alkenes afford tetrahydrofuran products bearing three stereocenters in good yield with moderate to good stereoselectivity.
University of Michigan, Department of Chemistry, 930 N. University Ave, Ann Arbor, Michigan, 48109-1055.
Michael B
MB
Hay
John P
JP
Wolfe