Preventive HIV vaccine acceptability and behavioral risk compensation among a random sample of high-risk adults in Los Angeles (LA VOICES).
OBJECTIVE
To assess HIV vaccine acceptability among high-risk adults in Los Angeles.


METHODS
Sexually transmitted disease clinics, needle/syringe exchange programs, Latino community health/HIV prevention programs.


METHODS
Cross-sectional survey using conjoint analysis. Participants were randomly selected using three-stage probability sampling.


METHODS
Sixty-minute structured interviews. Participants rated acceptability of eight hypothetical vaccines, each with seven dichotomous attributes, and reported post-vaccination risk behavior intentions.


RESULTS
Participants (n=1164; 55.7 percent male, 82.4 percent ethnic minority, mean age=37.4 years) rated HIV vaccine acceptability from 28.4 to 88.6; mean=54.5 (SD=18.8; 100-point scale). Efficacy had the greatest impact on acceptability, followed by side effects and out-of-pocket cost. Ten percent would decrease condom use after vaccination.


CONCLUSIONS
Findings support development of social marketing interventions to increase acceptability of "partial efficacy" vaccines, behavioral interventions to mitigate risk compensation, and targeted cost subsidies.
Newman
Peter A
PA
Centre for Applied Social Research, Factor-Inwentash Faculty of Social Work, University of Toronto, 246 Bloor Street West, Toronto, Ontario, Canada.
Lee
Sung-Jae
SJ
Duan
Naihua
N
Rudy
Ellen
E
Nakazono
Terry K
TK
Boscardin
John
J
Kakinami
Lisa
L
Shoptaw
Steven
S
Diamant
Allison
A
Cunningham
William E
WE
D016915:AIDS Vaccines / Q000627:therapeutic use*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections / Q000276:immunology* / Q000517:prevention & control*; D006630:Hispanic or Latino; D006801:Humans; D007407:Interviews as Topic; D015141:Los Angeles; D008297:Male; D008875:Middle Aged; D010342:Patient Acceptance of Health Care; D012309:Risk-Taking; D047568:Unsafe Sex; D055815:Young Adult
D016915:AIDS Vaccines