Increased blood oxidative stress in amphetamine users.
Amphetamine derivatives have been shown to be a potential brain neurotoxin based on the production of free radicals that occurs after administration. The purpose of this study was to examine the lipid peroxidation and antioxidant enzymes in the blood of amphetamine users. The plasma lipid peroxidation was determined and reported as thiobarbituric acid reactive substance and was significantly increased (+21%), whereas the activities of the erythrocyte antioxidant enzymes glutathione peroxidase, catalase, and superoxide dismutase were significantly decreased (-32%, -14% and -31%, respectively) in amphetamine users. These results implicated the potential role of oxidative stress in amphetamine-induced neurotoxicity.
Center for Neuroscience, Faculty of Science, Mahidol University, Thailand.
Piyarat
P
Govitrapong
Parichart
P
Boontem
Patcharee
P
Kooncumchoo
Sirinthorn
S
Pinweha
Jatuporn
J
Namyen
Yupin
Y
Sanvarinda
Smith
S
Vatanatunyakum
D015102:3,4-Dihydroxyphenylacetic Acid / Q000097:blood; D000328:Adult; D019969:Amphetamine-Related Disorders / Q000503:physiopathology*; D002374:Catalase / Q000097:blood; D002908:Chronic Disease; D004298:Dopamine / Q000097:blood; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects / Q000502:physiology; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects* / Q000502:physiology; D017382:Reactive Oxygen Species / Q000097:blood; D012016:Reference Values; D013482:Superoxide Dismutase / Q000097:blood; D055815:Young Adult
D017382:Reactive Oxygen Species; D015102:3,4-Dihydroxyphenylacetic Acid; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D004298:Dopamine