Cerebellum can be a possible generator of progressive myoclonus.
A 19-month-old girl presented with progressive myoclonic jerking of both proximal lower extremities. On her brain magnetic resonance imaging (MRI), the authors found an ill-defined mass involving cerebellar vermis and the right middle cerebellar peduncle. ( 11)C-methionine positron emission tomography (PET) showed no abnormalities, but (18)F-fluorodeoxyglucose ((18)F-FDG) PET revealed a well-defined hypermetabolic focus. Depth electrodes were inserted deep into the mass, which recorded focal slow waves associated with the clinical myoclonus. Following the removal of the tumor, the myoclonus was completely resolved with no neurological deficit. Here, the authors present a case showing progressive myoclonus associated with a cerebellar ganglioglioma with the electrophysiological data, which provides strong supportive evidence that the cerebellum can be a myoclonus generator.
Koh
Kyung Nam
KN
Department of Pediatrics, Seoul National University College of Medicine, Seoul 45229., Korea.
Lim
Byung Chan
BC
Hwang
Hee
H
Park
June Dong
JD
Chae
Jong Hee
JH
Kim
Ki Joong
KJ
Hwang
Yong-Seung
YS
Kim
Seung-Ki
SK
Wang
Kyu-Chang
KC
Moon
Han Ku
HK
D002528:Cerebellar Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D004569:Electroencephalography; D005260:Female; D018303:Ganglioglioma / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D009207:Myoclonus / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D011877:Radionuclide Imaging; D016896:Treatment Outcome