CTX-M and ampC beta-lactamases contributing to increased prevalence of ceftriaxone-resistant Escherichia coli in Changi General Hospital, Singapore.
Data from an 800-bed hospital showed an increase in the incidence density of ceftriaxone-resistant Escherichia coli, from 13.1 to 21.7 per 100 000 inpatient days over a 4-year period. Detailed testing performed on 54 E. coli isolates showed bla(CTX-M) extended-spectrum beta-lactamase (ESBL) genes (n = 37) and bla(CMY-like)ampC genes (n = 15). Typing data showed only limited clonal transmission in isolates with ESBL.
Department of Laboratory Medicine, Changi General Hospital, Singapore, Singapore. thean_yen_tan@cgh.com.sg
Thean Yen
TY
Tan
Lily Siew Yong
LS
Ng
Jie
J
He
Li Yang
LY
Hsu
D000368:Aged; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D015373:Bacterial Typing Techniques; D002443:Ceftriaxone / Q000494:pharmacology*; D016000:Cluster Analysis; D016172:DNA Fingerprinting; D024881:Drug Resistance, Bacterial; D016521:Electrophoresis, Gel, Pulsed-Field; D004926:Escherichia coli / Q000187:drug effects* / Q000201:enzymology* / Q000302:isolation & purification; D004927:Escherichia coli Infections / Q000382:microbiology; D029968:Escherichia coli Proteins / Q000096:biosynthesis*; D005260:Female; D005838:Genotype; D006769:Hospitals, General; D006801:Humans; D008297:Male; D015995:Prevalence; D012846:Singapore; D001618:beta-Lactamases / Q000096:biosynthesis*
D000900:Anti-Bacterial Agents; D029968:Escherichia coli Proteins; D002443:Ceftriaxone; D001618:beta-Lactamases