Biological activity of a phloroglucinol glucoside derivative from Conyza aegyptiaca.
The phloroglucinol glucoside derivative [2,4-dihydroxy-6-(beta-D-glucopyranosyloxy)phenyl]-butan-1-one (1), roseoside (2), and kaempferol-3-O-beta-D-glucopyranoside (3) were isolated from the aerial parts of Conyza aegyptiaca (L.). To the best of our knowledge, this is the first isolation of compounds 1-3 from C. aegyptiaca. Their structures were determined by spectroscopic techniques including, IR, HR-EIMS, and extensive 500 MHz 1D- and 2D-NMR analyses (1H, 13C NMR, DEPT, 1H-1H COSY, HMQC and HMBC experiments). The antioxidant activity of 1, using the DPPH assay, was investigated; in addition, 1 was investigated against different types of cell lines, including Hep-G2, HCT-116, and RAW 264.7 for its cytotoxic effects. Also, this is the first report on the activity of 1.
Chemistry Department, College of Science, King Faisal University, P. O. Box 1759, Hofuf 380, Saudi Arabia.
Ahmed A
AA
Mahmoud
Shar S
SS
Al-Shihry
Mohamed-Elamir F
ME
Hegazy
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D001713:Biphenyl Compounds / Q000737:chemistry; D006528:Carcinoma, Hepatocellular; D045744:Cell Line, Tumor / Q000187:drug effects; D003110:Colonic Neoplasms; D035401:Conyza / Q000737:chemistry*; D004534:Egypt; D005960:Glucosides / Q000302:isolation & purification / Q000494:pharmacology; D008113:Liver Neoplasms; D008264:Macrophages / Q000187:drug effects / Q000502:physiology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D008958:Models, Molecular; D010696:Phloroglucinol / Q000302:isolation & purification* / Q000494:pharmacology; D010851:Picrates / Q000737:chemistry; D035261:Plant Components, Aerial / Q000737:chemistry
D000975:Antioxidants; D001713:Biphenyl Compounds; D005960:Glucosides; D010851:Picrates; C004931:1,1-diphenyl-2-picrylhydrazyl; D010696:Phloroglucinol