Adipokines: emerging therapeutic targets.
Adipose tissue can affect human physiology through its secreted products, collectively termed adipokines, which mediate complex crosstalk between organs. Adipokines have been linked to a wide range of pathologies in many tissues; however, the pathophysiological significance of these cytokines remains poorly understood, and more research is needed in this area. Adipokines may have both beneficial and potentially harmful effects; for example, leptin reduces body weight, but also impairs immune responses. A cautious approach is therefore warranted when considering the pharmacological manipulation of adipokines to treat diseases, and novel approaches may be required to target specific organs or actions to reduce the potential for adverse effects.
Kos
Katarina
K
University Hospital Aintree, Diabetes and Endocrinology Research Unit, Longmoor Lane, Liverpool L9 7AL, UK. katarina.kos@pcmd.ac.uk
Wilding
John P H
JP
D054392:Adipokines / Q000378:metabolism*; D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D001835:Body Weight / Q000502:physiology; D016503:Drug Delivery Systems; D006801:Humans; D020738:Leptin / Q000276:immunology / Q000378:metabolism
D054392:Adipokines; D020738:Leptin