Relationship between interleukin-6 levels and ambulatory blood pressure in women with polycystic ovary syndrome.
OBJECTIVE
To determine 24-hour ambulatory blood pressures (ABP) in patients with polycystic ovary syndrome (PCOS) and its relationship with interleukin-6 (IL-6).


METHODS
Prospective controlled study.


METHODS
University hospital.


METHODS
Fifty-four PCOS patients.


METHODS
Ambulatory blood pressure monitoring was conducted. Anthropometric, hormonal, metabolic, and inflammatory parameters, including plasma IL-6, C-reactive protein (CRP), fibrinogen, and nitric oxide (NO), were measured in each subject.


METHODS
Ambulatory blood pressure and plasma IL-6, CRP, fibrinogen, and NO.


RESULTS
Serum IL-6 levels of PCOS women in the highest systolic blood pressure (SBP) quartile were significantly higher than those of women in the lowest SBP quartile. The high serum IL-6 levels (serum IL-6 level>or=5.1 pg/mL) were associated with a higher probability of raised SBP (>/=126 mm Hg), with an odds ratio of 2.2 (95% confidence interval 0.8-7.9). The systolic and diastolic (DBP) blood pressures were significantly related to serum IL-6 levels. The IL-6 levels were positively and significantly correlated with serum CRP levels. Interleukin-6 and CRP were negatively and significantly correlated with serum NO levels. CONLUSION(S): The results suggest that raised plasma IL-6 levels may be related to ambulatory SBP and DBP in PCOS.
Kaya
Cemil
C
Department of Obstetrics and Gynecology, Faculty of Medicine, Ufuk University, Ankara, Turkey. Electronic address: kayacemil000@yahoo.com.
Pabuçcu
Recai
R
Department of Obstetrics and Gynecology, Faculty of Medicine, Ufuk University, Ankara, Turkey.
Koca
Cemile
C
Department of Biochemistry, Fatih University, Ankara, Turkey.
Oğuz
A Kemal
AK
Department of Internal Medicine, Faculty of Medicine, Ufuk University, Ankara, Turkey.
Erkan
Aycan Fahri
AF
Department of Cardiology, Faculty of Medicine, Ufuk University, Ankara, Turkey.
Korkmaz
Ayhan
A
Department of Physiology, Gazi University, Ankara, Turkey.
Erbaş
Deniz
D
Department of Physiology, Gazi University, Ankara, Turkey.
D000328:Adult; D001794:Blood Pressure / Q000502:physiology; D018660:Blood Pressure Monitoring, Ambulatory; D015992:Body Mass Index; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000503:physiopathology*; D012044:Regression Analysis; D055815:Young Adult
D015850:Interleukin-6