MUTYH-associated polyposis and colorectal cancer.
This article reviews the role of defective base excision repair, and MUTYH specifically, in colorectal cancer etiology and discusses the consequences of MUTYH gene defects, with particular emphasis on clinical relevance to colorectal polyposis, colorectal cancer risk, and appraising the risk of extra-colonic malignancy. Evidence guiding clinical practice, in terms of surveillance recommendations and options for surgical and other prophylactic interventions, is reviewed.
Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and MRC Human Genetics Unit, Western General Hospital, Edinburgh EH4 2XU, UK. malcolm.dunlop@hgu.mrc.ac.uk
Malcolm G
MG
Dunlop
Susan M
SM
Farrington
D011125:Adenomatous Polyposis Coli / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D045647:DNA Glycosylases / Q000235:genetics*; D004260:DNA Repair; D006801:Humans
D045647:DNA Glycosylases; C061738:mutY adenine glycosylase