Cytotoxic diterpenoids from Croton argyrophylloides.
Two new diterpenes, 1 and 2, together with the known ent-15-oxo-kaur-16-en-18-oic acid (3), were isolated from the bark of Croton argyrophylloides. The structural characterization of 1 and 2 was determined on the basis of spectroscopic data interpretation. The cytotoxicity of each compound was evaluated against HL-60 (leukemia), MDAMB-435 (melanoma), SF-295 (glioblastoma), and HCT-8 (colon carcinoma) human tumor cell lines and against human peripheral blood mononuclear cells. The hemolytic potential in mouse erythrocytes was also tested for 1-3.
Santos
Hélcio S
HS
Centro de Ciências Exatas e Tecnologia, Universidade Estadual Vale do Acaraú, 62040-370, Sobral, CE, Brazil.
Barros
Francisco W A
FW
Albuquerque
Maria Rose Jane R
MR
Bandeira
Paulo N
PN
Pessoa
Claúdia
C
Braz-Filho
Raimundo
R
Monte
Francisco J Q
FJ
Leal-Cardoso
Jose Henrique
JH
Lemos
Telma L G
TL
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D001938:Brazil; D029802:Croton / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D004912:Erythrocytes / Q000187:drug effects; D018922:HL-60 Cells; D053878:Hemolytic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D051379:Mice; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*
C545050:14-epi-hyalic acid; D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D053878:Hemolytic Agents; C545049:rel-(1R,4aR,5R,8R)-methyl-7-(1-(methoxycarbonyl)vinyl)-5,8-diacetoxy-1,2,3,4a,5,6,7,8,9,10,10a-dodecahydro-1,4a-dimethyl-2-oxophenanthrene-1-carboxylate