EMMA--mouse mutant resources for the international scientific community.
The laboratory mouse is the premier animal model for studying human disease and thousands of mutants have been identified or produced, most recently through gene-specific mutagenesis approaches. High throughput strategies by the International Knockout Mouse Consortium (IKMC) are producing mutants for all protein coding genes. Generating a knock-out line involves huge monetary and time costs so capture of both the data describing each mutant alongside archiving of the line for distribution to future researchers is critical. The European Mouse Mutant Archive (EMMA) is a leading international network infrastructure for archiving and worldwide provision of mouse mutant strains. It operates in collaboration with the other members of the Federation of International Mouse Resources (FIMRe), EMMA being the European component. Additionally EMMA is one of four repositories involved in the IKMC, and therefore the current figure of 1700 archived lines will rise markedly. The EMMA database gathers and curates extensive data on each line and presents it through a user-friendly website. A BioMart interface allows advanced searching including integrated querying with other resources e.g. Ensembl. Other resources are able to display EMMA data by accessing our Distributed Annotation System server. EMMA database access is publicly available at http://www.emmanet.org.
European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Phil
P
Wilkinson
Jitka
J
Sengerova
Raffaele
R
Matteoni
Chao-Kung
CK
Chen
Gaetan
G
Soulat
Abel
A
Ureta-Vidal
Sabine
S
Fessele
Michael
M
Hagn
Marzia
M
Massimi
Karen
K
Pickford
Richard H
RH
Butler
Susan
S
Marschall
Ann-Marie
AM
Mallon
Amanda
A
Pickard
Marcello
M
Raspa
Ferdinando
F
Scavizzi
Martin
M
Fray
Vanessa
V
Larrigaldie
Johan
J
Leyritz
Ewan
E
Birney
Glauco P
GP
Tocchini-Valentini
Steve
S
Brown
Yann
Y
Herault
Lluis
L
Montoliu
Martin Hrabé
MH
de Angelis
Damian
D
Smedley
D000818:Animals; D002875:Chromosomes; D019295:Computational Biology / Q000379:methods* / Q000639:trends; D030541:Databases, Genetic; D030561:Databases, Nucleic Acid; D030562:Databases, Protein; D016247:Information Storage and Retrieval / Q000379:methods; D020407:Internet; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008957:Models, Genetic; D017434:Protein Structure, Tertiary; D012984:Software; D014584:User-Computer Interface