Synthesis of (+)-CP-99,994 via Pd(0)-catalyzed asymmetric allylic and homoallylic C-H Diamination of terminal olefin.
This paper describes an asymmetric synthesis of the potent substance P receptor antagonist (+)-CP-99,994 from 4-phenyl-1-butene via Pd(0)-catalyzed asymmetric allylic and homoallylic C-H diamination.
Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, USA.
Renzhong
R
Fu
Baoguo
B
Zhao
Yian
Y
Shi
D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D003959:Diamines / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D010880:Piperidines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D000475:Alkenes; D003959:Diamines; D010880:Piperidines; C080755:3-(2-methoxybenzylamino)-2-phenylpiperidine; D010165:Palladium