Effects of soman poisoning on mitochondrial respiratory enzyme activity in the mouse hippocampus and cerebral cortex.
Mitochondrial dysfunctions have been highlighted as a contributing factor in epileptic seizures and subsequent neuronal cell death. Soman is an irreversible inhibitor of cholinesterase, triggering epileptic seizures leading to massive neuronal cell death in brain areas, such as the hippocampus and cerebral cortex. Mitochondrial respiratory chain enzymatic assays were performed in hippocampus and cerebral cortex homogenates from mouse brains collected 3 hours, 24 hours, 3 days, and 7 days after soman poisoning. Our results suggest that mitochondrial enzymatic alterations stem more likely from secondary effects of the poisoning, rather than from any fallout effect from neuronal cell death.
Collombet
Jean-Marc
JM
Département de Toxicologie-CRSSA, La Tronche, France. jmcollombet@crssa.net
Baubichon
Dominique
D
Four
Elise
E
Sentenac-Masqueliez
Catherine
C
Lallement
Guy
G
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D001921:Brain; D002118:Calcium / Q000378:metabolism; D002540:Cerebral Cortex / Q000187:drug effects* / Q000378:metabolism; D002801:Cholinesterase Reactivators / Q000494:pharmacology; D004193:Discrimination Learning / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D008928:Mitochondria / Q000187:drug effects* / Q000201:enzymology; D009474:Neurons / Q000187:drug effects; D012137:Respiratory System / Q000187:drug effects* / Q000201:enzymology; D012999:Soman / Q000506:poisoning*
D002801:Cholinesterase Reactivators; D012999:Soman; D002118:Calcium