Real-time detection of deoxyribonucleic acid bases via their negative differential conductance signature.
In this Brief Report, we present a method for the real-time detection of the bases of the deoxyribonucleic acid using their signatures in negative differential conductance measurements. The present methods of electronic detection of deoxyribonucleic acid bases are based on a statistical analysis because the electrical currents of the four bases are weak and do not differ significantly from one base to another. In contrast, we analyze a device that combines the accumulated knowledge in nanopore and scanning tunneling detection and which is able to provide very distinctive electronic signatures for the four bases.
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Physics Department, University of Bucharest, P.O. Box MG-11, 077125 Bucharest, Romania.
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