Prospective comparison of tuberculin skin test and QuantiFERON-TB Gold In-Tube assay for the detection of latent tuberculosis infection among healthcare workers in a low-incidence setting.
We compared the results of the tuberculin skin test with the results of the QuantiFERON-TB Gold In-Tube (QFT-GIT) assay among 182 low-risk healthcare workers. Overall agreement and specificity were high, but the tests did not agree on positive results. Only 2 of 5 positive QFT-GIT assay results could be confirmed with repeat analyses. Indeterminate results were associated with potential immunosuppression.
Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505, USA. cvx5@cdc.gov
Kristin J
KJ
Cummings
Tamara S
TS
Smith
Elizabeth S
ES
Shogren
Rashida
R
Khakoo
Sharmilarani
S
Nanda
Lana
L
Bunner
Ann
A
Smithmyer
Darlene
D
Soccorsi
Michael L
ML
Kashon
Gerald H
GH
Mazurek
Lloyd N
LN
Friedman
David N
DN
Weissman
D006282:Health Personnel; D006801:Humans; D015994:Incidence; D007371:Interferon-gamma / Q000097:blood*; D055985:Latent Tuberculosis / Q000175:diagnosis* / Q000453:epidemiology / Q000382:microbiology; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D011933:Reagent Kits, Diagnostic; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014374:Tuberculin Test / Q000379:methods*
D011933:Reagent Kits, Diagnostic; D007371:Interferon-gamma