Review of the molecular pathogenesis of the odontogenic keratocyst.
The odontogenic keratocyst (keratocystic odontogenic tumour) (OKC) is one of the most prevalent odontogenic tumours. Since its initial description, a number of studies have focused on different aspects of this lesion, attempting to explain its distinctive biological behaviour. In this review the authors address the main genetic and epigenetic alterations reported on this tumour. Although most of the knowledge on this field is not being used in the clinical practice, some perspectives of translational studies are discussed.
Gomes
Carolina Cavaliéri
CC
Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Diniz
Marina Gonçalves
MG
Gomez
Ricardo Santiago
RS
D057890:Epigenomics; D016158:Genes, p53 / Q000235:genetics; D006801:Humans; D008336:Mandibular Diseases / Q000235:genetics*; D035683:MicroRNAs / Q000378:metabolism; D009154:Mutation; D009807:Odontogenic Cysts / Q000235:genetics*; D000072079:Patched Receptors; D011956:Receptors, Cell Surface / Q000235:genetics
D035683:MicroRNAs; D000072079:Patched Receptors; D011956:Receptors, Cell Surface