Comparative efficiencies of photothermal destruction of malignant cells using antibody-coated silica@Au nanoshells, hollow Au/Ag nanospheres and Au nanorods.
Three Au-based nanomaterials (silica@Au nanoshells, hollow Au/Ag nanospheres and Au nanorods) were evaluated for their comparative photothermal efficiencies at killing three types of malignant cells (A549 lung cancer cells, HeLa cervix cancer cells and TCC bladder cancer cells) using a CW NIR laser. Photodestructive efficiency was evaluated as a function of the number of nanoparticles required to destroy the cancer cells under 808 nm laser wavelength at fixed laser power. Of the three nanomaterials, silica@Au nanoshells needed the minimum number of particles to produce effective photodestruction, whereas Au nanorods needed the largest number of particles. Together with the calculated photothermal conversion efficiency, the photothermal efficiency rankings are silica@Au nanoshells > hollow Au/Ag nanospheres > Au nanorods. Additionally, we found that HeLa cells seem to present better heat tolerance than the other two cancer cell lines.
Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan.
Fong-Yu
FY
Cheng
Chen-Tai
CT
Chen
Chen-Sheng
CS
Yeh
D000906:Antibodies / Q000737:chemistry; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006046:Gold / Q000494:pharmacology*; D006367:HeLa Cells; D006801:Humans; D053685:Laser Therapy / Q000379:methods*; D007834:Lasers; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000627:therapeutic use; D046529:Microscopy, Electron, Transmission; D008856:Microscopy, Fluorescence; D054118:Nanospheres / Q000737:chemistry / Q000627:therapeutic use; D009369:Neoplasms / Q000473:pathology / Q000628:therapy; D012822:Silicon Dioxide / Q000737:chemistry; D012834:Silver / Q000494:pharmacology*; D013696:Temperature
D000906:Antibodies; D012834:Silver; D006046:Gold; D012822:Silicon Dioxide