[Cytoflavine effect on exudative-destructive manifestations of lung tuberculosis in children and teenagers].
A prospective, placebo-controlled ordinary-"blind"-randomized investigation of the cytoflavine effect on roentgenological manifestations of exudative-destructive processes in pulmonary tissues in cases of tuberculosis in children and teenagers has been performed in comparison to changes in the the functional state of neutrophilic granulocytes and Micobacterium tuberculosis incidence in sputum during a standard four-months course of antituberculosis therapy. It is estasblished that the administration of cytoflavine at the beginning of antituberculosis complex therapy (10 mL per 24 hours, for 5 days) results in rapid suppression of exudative-destructive disease manifestations and quick cavity repair in tuberculosis-affected areas, at an increase in the probability of outcome with "small post-tuberculosis changes". The rapid suppression of exudative-destructive processes in patients having received cytoflavine was caused by its optimizing influence on phagocytic blood capacity and did not depend on the development of abacillarity in patients.
I A
IA
Volchegorskiĭ
P N
PN
Novoselov
I A
IA
Denisenko
D000293:Adolescent; D000995:Antitubercular Agents / Q000008:administration & dosage*; D002648:Child; D004338:Drug Combinations; D005260:Female; D005486:Flavin Mononucleotide / Q000008:administration & dosage*; D006801:Humans; D007290:Inosine Diphosphate / Q000008:administration & dosage*; D008168:Lung / Q000378:metabolism / Q000382:microbiology / Q000473:pathology; D008297:Male; D009169:Mycobacterium tuberculosis; D009504:Neutrophils / Q000378:metabolism / Q000382:microbiology; D009536:Niacinamide / Q000008:administration & dosage*; D011446:Prospective Studies; D013183:Sputum / Q000378:metabolism / Q000382:microbiology; D013386:Succinates / Q000008:administration & dosage*; D013997:Time Factors; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy* / Q000378:metabolism* / Q000382:microbiology / Q000473:pathology
D000995:Antitubercular Agents; D004338:Drug Combinations; D013386:Succinates; C507879:cytoflavin; D009536:Niacinamide; D005486:Flavin Mononucleotide; D007290:Inosine Diphosphate