[The role of changes in matrix metalloproteases and chitotriosidase in the mechanism of protective effect of atorvastatin in experimental murine lipemia].
The effect of atorvastatin on the activity of chitotriosidase (CTO) and total matrix metalloproteases (MMPs)-new markers of cardiovascular disorder-was studied on the model of murine lipemia induced by single administration of Triton WR 1339 in two doses, 500 mg/kg (mild lipemia) and 850 mg/kg (severe lipemia). A hypolipidemic effect of atorvastatin was observed in mice with mild lipemia, but not in those with severe lipemia. In both mild and severe lipemia cases, the serum CTO activity was increased upon the combined administration of atorvastatin and Triton WR 1339, correlating with cholesterol and triglyceride concentration. The total serum MMP activity decreased only in experiments with atorvastatin administration to intact mice. In mice with experimental lipemia induced by Triton WR 1339, the administration of atorvastatin also increased the ALT and AST activity in the blood serum.
Korolenko
T A
TA
Cherkanova
M S
MS
Savchenko
N G
NG
Klishevich
M S
MS
D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology*; D000069059:Atorvastatin; D002784:Cholesterol / Q000097:blood; D003902:Detergents / Q000009:adverse effects / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005260:Female; D006538:Heptanoic Acids / Q000494:pharmacology*; D006596:Hexosaminidases / Q000097:blood*; D006949:Hyperlipidemias / Q000097:blood* / Q000139:chemically induced / Q000517:prevention & control*; D020782:Matrix Metalloproteinases / Q000097:blood*; D051379:Mice; D008813:Mice, Inbred ICR; D011092:Polyethylene Glycols / Q000009:adverse effects / Q000494:pharmacology; D011758:Pyrroles / Q000494:pharmacology*; D014280:Triglycerides / Q000097:blood
D000924:Anticholesteremic Agents; D003902:Detergents; D006538:Heptanoic Acids; D011758:Pyrroles; D014280:Triglycerides; D011092:Polyethylene Glycols; D002784:Cholesterol; D000069059:Atorvastatin; D006596:Hexosaminidases; C086400:chitotriosidase; D020782:Matrix Metalloproteinases; C016811:tyloxapol