Close relationship between serum concentrations of 1,5-anhydroglucitol and uric acid in non-diabetic male subjects implies common renal transport system.
BACKGROUND
1,5-Anhydroglucitol is found in food. We determined factors other than glucosuria that affect serum 1,5-anhydroglucitol (1,5-AG) concentration.


METHODS
The relationships between serum 1,5-AG concentration and metabolic parameters were investigated in 158 males with normal glucose tolerance verified by an oral glucose tolerance test.


RESULTS
Serum uric acid was positively correlated to 2-h plasma glucose and serum 1,5-AG concentrations. Serum 1,5-AG levels were not different between hyperuricemic and normouricemic subjects, though those with normouricemia had lower 2-h plasma glucose concentrations than subjects with hyperuricemia. The association between 1,5-AG and uric acid in serum was still evident after adjustment with 2-h plasma glucose concentration. Multivariate regression analyses demonstrated that serum uric acid was an independent variable related to serum 1,5-AG and vice versa.


CONCLUSIONS
1,5-AG and uric acid may share in part a common renal tubular transport system, independent of glucose excretion.
Koga
M
M
Department of Internal Medicine, Kinki Central Hospital, Japan.
Murai
J
J
Saito
H
H
Mukai
M
M
Kasayama
S
S
Moriwaki
Y
Y
Yamamoto
T
T
D000328:Adult; D001692:Biological Transport; D001786:Blood Glucose; D003847:Deoxyglucose / Q000097:blood*; D005951:Glucose Tolerance Test; D006801:Humans; D007684:Kidney Tubules / Q000378:metabolism*; D008297:Male; D008660:Metabolism; D008875:Middle Aged; D014527:Uric Acid / Q000097:blood*
D001786:Blood Glucose; D014527:Uric Acid; C006584:1,5-anhydroglucitol; D003847:Deoxyglucose