Susceptibility of Pseudomonas aeruginosa to catechol-substituted cephalosporin is unrelated to the pyochelin-Fe transporter FptA.
Previously it has been postulated that the pyochelin-Fe outer membrane transporter, FptA, is involved in the uptake of catechol-substituted cephalosporins in Pseudomonas aeruginosa. Iron uptake and antibacterial activity studies on different mutants showed clearly that FptA is unable to bind and transport these antibiotics.
Université de Strasbourg-CNRS, ESBS, Blvd Sébastien Brant, 67413, Illkirch, Strasbourg, France.
Françoise
F
Hoegy
Michael N
MN
Gwynn
Isabelle J
IJ
Schalk
D001425:Bacterial Outer Membrane Proteins / Q000378:metabolism*; D002396:Catechols / Q000737:chemistry*; D002511:Cephalosporins / Q000737:chemistry / Q000494:pharmacology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D011956:Receptors, Cell Surface / Q000378:metabolism*
D001425:Bacterial Outer Membrane Proteins; D002396:Catechols; D002511:Cephalosporins; C075523:FPTA protein, Pseudomonas; D011956:Receptors, Cell Surface; C034221:catechol