Short-term modified alternate-day fasting: a novel dietary strategy for weight loss and cardioprotection in obese adults.
BACKGROUND
The ability of modified alternate-day fasting (ADF; ie, consuming 25% of energy needs on the fast day and ad libitum food intake on the following day) to facilitate weight loss and lower vascular disease risk in obese individuals remains unknown.


OBJECTIVE
This study examined the effects of ADF that is administered under controlled compared with self-implemented conditions on body weight and coronary artery disease (CAD) risk indicators in obese adults.


METHODS
Sixteen obese subjects (12 women, 4 men) completed a 10-wk trial, which consisted of 3 phases: 1) a 2-wk control phase, 2) a 4-wk weight loss/ADF controlled food intake phase, and 3) a 4-wk weight loss/ADF self-selected food intake phase.


RESULTS
Dietary adherence remained high throughout the controlled food intake phase (days adherent: 86%) and the self-selected food intake phase (days adherent: 89%). The rate of weight loss remained constant during controlled food intake (0.67 +/- 0.1 kg/wk) and self-selected food intake phases (0.68 +/- 0.1 kg/wk). Body weight decreased (P < 0.001) by 5.6 +/- 1.0 kg (5.8 +/- 1.1%) after 8 wk of diet. Percentage body fat decreased (P < 0.01) from 45 +/- 2% to 42 +/- 2%. Total cholesterol, LDL cholesterol, and triacylglycerol concentrations decreased (P < 0.01) by 21 +/- 4%, 25 +/- 10%, and 32 +/- 6%, respectively, after 8 wk of ADF, whereas HDL cholesterol remained unchanged. Systolic blood pressure decreased (P < 0.05) from 124 +/- 5 to 116 +/- 3 mm Hg.


CONCLUSIONS
These findings suggest that ADF is a viable diet option to help obese individuals lose weight and decrease CAD risk. This trial was registered at clinicaltrials.gov as UIC-004-2009.
Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL 60612, USA. varady@uic.edu
Krista A
KA
Varady
Surabhi
S
Bhutani
Emily C
EC
Church
Monica C
MC
Klempel
D000328:Adult; D000368:Aged; D002784:Cholesterol / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003327:Coronary Disease / Q000517:prevention & control*; D002149:Energy Intake; D005215:Fasting / Q000502:physiology*; D005260:Female; D006339:Heart Rate; D006801:Humans; D006973:Hypertension / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000534:rehabilitation*; D050177:Overweight / Q000534:rehabilitation; D010352:Patient Dropouts; D013599:Systole; D014280:Triglycerides / Q000097:blood; D015431:Weight Loss
D008078:Cholesterol, LDL; D014280:Triglycerides; D002784:Cholesterol