Catalytic antibodies: balancing between Dr. Jekyll and Mr. Hyde.
The immunoglobulin molecule is a perfect template for the de novo generation of biocatalytic functions. Catalytic antibodies, or abzymes, obtained by the structural mimicking of enzyme active sites have been shown to catalyze numerous chemical reactions. Natural enzyme analogs for some of these reactions have not yet been found or possibly do not exist at all. Nowadays, the dramatic breakthrough in antibody engineering and expression technologies has promoted a considerable expansion of immunoglobulin's medical applications and is offering abzymes a unique chance to become a promising source of high-precision "catalytic vaccines." At the same time, the discovery of natural abzymes on the background of autoimmune disease revealed their beneficial and pathogenic roles in the disease progression. Thus, the conflicting Dr. Jekyll and Mr. Hyde protective and destructive essences of catalytic antibodies should be carefully considered in the development of therapeutic abzyme applications.
Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow 117997, Russia.
Alexey
A
Belogurov
Arina
A
Kozyr
Natalia
N
Ponomarenko
Alexander
A
Gabibov
D000544:Alzheimer Disease / Q000276:immunology; D000818:Animals; D017151:Antibodies, Catalytic / Q000737:chemistry* / Q000502:physiology*; D015551:Autoimmunity; D001671:Biochemistry / Q000379:methods; D003920:Diabetes Mellitus / Q000276:immunology; D005169:Factor VIII / Q000502:physiology; D006801:Humans; D007136:Immunoglobulins / Q000737:chemistry; D008954:Models, Biological; D009103:Multiple Sclerosis / Q000276:immunology; D015202:Protein Engineering / Q000379:methods; D018805:Sepsis / Q000276:immunology; D013966:Thyroiditis / Q000276:immunology; D014612:Vaccines
D017151:Antibodies, Catalytic; D007136:Immunoglobulins; D014612:Vaccines; D005169:Factor VIII