Fulminant parvovirus B19-associated pancarditis with haemophagocytic lympho-histiocytosis in an immunocompetent adult.
Myocarditis is a common cardiac disease that is identified on routine postmortem examinations. Initially, coxsackie viruses, other enteroviruses and adenoviruses were thought to be more common causes of myocarditis; however, recently, parvovirus B19 (PVB19) as well as human herpesvirus 6 (HHV6) have entered the arena. We describe autopsy findings of a patient who had a lethal myocarditis with haemophagocytic lympho-histiocytosis in a course of systemic PVB19 infection. The present case illustrates the unusually severe and rapid course of PVB19 myocarditis with associated haemophagocytic lympho-histiocytosis leading to death.
Departments of Histopathology, Virology and Pulmonary Medicine, PGIMER, Chandigarh, India. docaman5@hotmail.com
Amanjit
A
Bal
Baijayantimala
B
Mishra
Navneet
N
Singh
Ashim
A
Das
S K
SK
Jindal
D000328:Adult; D006801:Humans; D051359:Lymphohistiocytosis, Hemophagocytic / Q000473:pathology*; D008297:Male; D009205:Myocarditis / Q000473:pathology*; D010322:Parvoviridae Infections / Q000473:pathology*; D016732:Parvovirus B19, Human / Q000302:isolation & purification*