A highly active catalyst for Huisgen 1,3-dipolar cycloadditions based on the tris(triazolyl)methanol-Cu(I) structure.
A new tris(1-benzyl-1H-1,2,3-triazol-4-yl)methanol ligand 3 has been prepared by a triple Cu(I)-catalyzed alkyne-azide 1,3-dipolar cycloaddition (CuAAC). Ligand 3 forms a stable complex with CuCl, which catalyzes the Huisgen 1,3-dipolar cycloaddition on water or under neat conditions. Low catalyst loadings, short reaction times at room temperature, and compatibility with free amino groups make 3.CuCl an outstanding catalyst for CuAAC.
Ozçubukçu
Salih
S
Institute of Chemical Research of Catalonia (ICIQ), Av. Paisos Catalans, 16. 43007 Tarragona, Spain.
Ozkal
Erhan
E
Jimeno
Ciril
C
Pericàs
Miquel A
MA