Plasma fibrinogen levels and prognosis in patients with ovarian cancer: a multicenter study.
BACKGROUND
To evaluate pretherapeutic plasma fibrinogen levels as a prognostic parameter in patients with epithelial ovarian cancer (EOC). Materials and Methods. In the present multicenter study, pretherapeutic plasma fibrinogen levels were evaluated in 422 patients with EOC. Plasma fibrinogen levels were correlated with clinicopathological parameters and patient survival.


RESULTS
The mean (standard deviation) pretherapeutic plasma fibrinogen level was 450.0 (150.1) mg/dl. Elevated plasma fibrinogen levels were associated with advanced tumor stage (p = .01) and the presence of a postoperative residual tumor mass (p < .001), but not with histological grade (p = .1) and histological type (p = .8). In a multivariate Cox regression model, tumor stage (p < .001 and p < .001), postoperative residual tumor mass (p = .001 and p = .008), and plasma fibrinogen level (p < .001 and p = .002), but not histological type (p = .8 and p = .2), patient age (p = .9 and p = .9), and serum cancer antigen 125 (p = 0.2 and p = 0.3) and C-reactive protein (p = .2 and p = .3) levels, were associated with disease-free and overall survival, respectively. Histological grade was associated with overall but not with disease-free survival (p = .01 and p = .8), respectively.


CONCLUSIONS
Pretherapeutic plasma fibrinogen levels can be used as an independent prognostic parameter in patients with EOC.
Department of Obstetrics & Gynecology, Medical University of Vienna, Waehringer Guer 18-20, A-1090 Vienna, Austria. stephan.polterauer@meduniwien.ac.at
Stephan
S
Polterauer
Christoph
C
Grimm
Veronika
V
Seebacher
Nicole
N
Concin
Christian
C
Marth
Caroline
C
Tomovski
Heinrich
H
Husslein
Heinz
H
Leipold
Katrin
K
Hefler-Frischmuth
Clemens
C
Tempfer
Alexander
A
Reinthaller
Lukas
L
Hefler
D000367:Age Factors; D000704:Analysis of Variance; D000951:Antigens, Neoplasm / Q000097:blood; D014408:Biomarkers, Tumor / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D018572:Disease-Free Survival; D005260:Female; D005340:Fibrinogen / Q000032:analysis / Q000378:metabolism*; D006801:Humans; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D009367:Neoplasm Staging; D018365:Neoplasm, Residual; D010051:Ovarian Neoplasms / Q000097:blood* / Q000401:mortality* / Q000473:pathology; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies
D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D005340:Fibrinogen; D002097:C-Reactive Protein