Congenital transmission of human immunodeficiency virus, cytomegalovirus, and toxoplasmosis in a premature infant.
We report a preterm infant with congenital HIV-1, CMV, and toxoplasmosis coinfection, whose mother succumbed to probable cerebral toxoplasmosis. Despite repeated neuroimaging, retinal examinations and infant serologic tests, during the first 36 days of life, there was no evidence of congenital toxoplasmosis. However, subsequent tests showed cerebral calcifications, bilateral chorioretinitis, antitoxoplasma IgM antibody, and Toxoplasma gondii DNA in the cerebrospinal fluid by polymerase chain reaction.
Tan
Darrell H S
DH
Division of Infectious Diseases, University of Toronto, Ontario, Canada.
Asztalos
Elizabeth
E
Douglas
Davina
D
Read
Stanley
S
Bitnun
Ari
A
D000328:Adult; D044966:Anti-Retroviral Agents / Q000627:therapeutic use; D000981:Antiprotozoal Agents / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D003587:Cytomegalovirus; D003586:Cytomegalovirus Infections / Q000188:drug therapy / Q000635:transmission*; D004453:Echoencephalography; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000635:transmission*; D015497:HIV-1 / Q000235:genetics; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000188:drug therapy / Q000469:parasitology* / Q000821:virology*; D018445:Infectious Disease Transmission, Vertical; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy / Q000469:parasitology / Q000821:virology; D014122:Toxoplasma / Q000235:genetics; D014125:Toxoplasmosis, Congenital / Q000188:drug therapy / Q000635:transmission*
D044966:Anti-Retroviral Agents; D000981:Antiprotozoal Agents; D000998:Antiviral Agents