Recent ancestry of Kyasanur Forest disease virus.
Kyasanur Forest disease virus (KFDV) is enzootic to India and maintained in ticks, mammals, and birds. It causes severe febrile illness in humans and was first recognized in 1957 associated with a high number of deaths among monkeys in Kyasanur Forest. Genetic analysis of 48 viruses isolated in India during 1957-2006 showed low diversity (1.2%). Bayesian coalescence analysis of these sequences and those of KFDVs from Saudi Arabia and the People's Republic of China estimated that KFDVs have evolved at a mean rate of approximately 6.4 x 10(-4) substitutions/site/year, which is similar to rates estimated for mosquito-borne flaviviruses. KFDVs were estimated to have shared a common ancestor in approximately 1942, fifteen years before identification of the disease in India. These data are consistent with the view that KFD represented a newly emerged disease when first recognized. Recent common ancestry of KFDVs from India and Saudi Arabia, despite their large geographic separation, indicates long-range movement of virus, possibly by birds.
National Institute of Virology, Pune, India.
Rajeev
R
Mehla
Sandeep R P
SR
Kumar
Pragya
P
Yadav
Pradip V
PV
Barde
Prasanna N
PN
Yergolkar
Bobbie R
BR
Erickson
Serena A
SA
Carroll
Akhilesh C
AC
Mishra
Stuart T
ST
Nichol
Devendra T
DT
Mourya
D000818:Animals; D001499:Bayes Theorem; D001715:Bird Diseases / Q000453:epidemiology / Q000635:transmission / Q000821:virology; D001717:Birds; D002681:China / Q000453:epidemiology; D021821:Communicable Diseases, Emerging / Q000453:epidemiology / Q000635:transmission / Q000821:virology; D004669:Encephalitis Viruses, Tick-Borne / Q000235:genetics*; D019143:Evolution, Molecular; D000882:Haplorhini; D006801:Humans; D007194:India / Q000453:epidemiology; D007733:Kyasanur Forest Disease / Q000453:epidemiology / Q000635:transmission / Q000821:virology; D008322:Mammals; D008969:Molecular Sequence Data; D008992:Monkey Diseases / Q000453:epidemiology / Q000635:transmission / Q000821:virology; D010802:Phylogeny; D012529:Saudi Arabia / Q000453:epidemiology; D017422:Sequence Analysis, DNA; D017361:Viral Nonstructural Proteins / Q000235:genetics; D015678:Viral Structural Proteins / Q000235:genetics; D015047:Zoonoses / Q000453:epidemiology / Q000635:transmission / Q000821:virology
D017361:Viral Nonstructural Proteins; D015678:Viral Structural Proteins