Immunosuppressive withanolides from Withania coagulans.
Six new withanolides, withacoagulins A-F (1-6, resp.), together with ten known withanolides, 7-16, were isolated from the aerial parts of Withania coagulans. Their structures were determined by spectroscopic techniques including 1D- and 2D-NMR (1H, 13C, HMQC, and HMBC) and MS experiments. These compounds, including the crude extracts of this herb, exhibited strong inhibitory activities on the T- and B-cell proliferation.
Shanghai Research Center for Modernization of Traditional Chinese Medicine, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 199 Guoshoujing Road, Shanghai 201203, P. R. China.
Chao-Feng
CF
Huang
Lei
L
Ma
Li-Juan
LJ
Sun
Mumtaz
M
Ali
Mohammad
M
Arfan
Jian-Wen
JW
Liu
Li-Hong
LH
Hu
D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology; D049109:Cell Proliferation; D007166:Immunosuppressive Agents / Q000737:chemistry* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D010936:Plant Extracts / Q000737:chemistry; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D032341:Withania / Q000737:chemistry*; D054358:Withanolides / Q000737:chemistry* / Q000494:pharmacology
D007166:Immunosuppressive Agents; D010936:Plant Extracts; D054358:Withanolides