Hybrid organic-inorganic silica gel carriers with controlled drug-delivery properties.
Pure and modified silica materials were synthesised by a sol-gel process and used as carrier for the controlled release of ibuprofen, selected as model drug. A one-step synthesis was optimised for the preparation of various silica-drug composites by using tetraethoxysilane and 3-aminopropyltriethoxysilane as precursors at different molar ratios. The presence of aminopropyl groups on the silica surface influences the drug-delivery rate leading to a high degree the desorption process controlled.
Contessotto
Laura
L
Department of Chemistry University Cà Foscari, Consortium INSTM-RU of Venice, Calle Larga Santa Marta, 2137, 30123 Venice, Italy.
Ghedini
Elena
E
Pinna
Francesco
F
Signoretto
Michela
M
Cerrato
Giuseppina
G
Crocellà
Valentina
V
D000588:Amines / Q000737:chemistry; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry*; D007052:Ibuprofen / Q000737:chemistry / Q000378:metabolism; D009930:Organic Chemicals / Q000737:chemistry*; D044367:Phase Transition; D012821:Silanes / Q000737:chemistry; D058428:Silica Gel; D012822:Silicon Dioxide / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared
D000588:Amines; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D009930:Organic Chemicals; D012821:Silanes; C040733:tetraethoxysilane; D058428:Silica Gel; D012822:Silicon Dioxide; D007052:Ibuprofen