PARylation: strengthening the connection between cancer and pluripotency.
Pluripotency and tumorgenicity appear fundamentally linked. Recent investigations into the role of PARylation in chromatin remodeling (Ahel et al., 2009; Gottschalk et al., 2009), combined with the demonstration that p53 serves as a barrier to pluripotency (Banito et al., 2009), further strengthen this connection.
Deng
Wenbin
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Department of Cell Biology and Human Anatomy, Institute of Pediatric Regenerative Medicine, School of Medicine, University of California-Davis, 2425 Stockton Boulevard, Sacramento, CA 95817, USA.
D000818:Animals; D004265:DNA Helicases / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D004260:DNA Repair / Q000235:genetics / Q000502:physiology; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D006801:Humans; D051379:Mice; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism*; D011065:Poly(ADP-ribose) Polymerases / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D016159:Tumor Suppressor Protein p53
D004268:DNA-Binding Proteins; D016159:Tumor Suppressor Protein p53; D011065:Poly(ADP-ribose) Polymerases; D004265:DNA Helicases; C543585:CHD1L protein, human