Famotidine neither affects action potential parameters nor inhibits human ether-a-go-go-related gene (hERG) K+ current.
The direct effects of famotidine, a selective histamine H(2) receptor antagonist, on the cardiac repolarization process were assessed using two in vitro test systems. Neither famotidine (0.1 and 1 microM), nor its solvent, dimethylsulfoxide (0.1%), affected any of the action potential parameters of guinea-pig papillary muscles, whereas the positive control, dl-sotalol (30 microM), significantly prolonged the action potential duration. Moreover, neither famotidine (0.1, 1 and 10 microM) nor dimethylsulfoxide affected the human ether-a-go-go-related gene (hERG) K(+) current expressed in Chinese hamster ovary-K1 cells, whereas the positive control, E-4031 (0.1 microM), significantly decreased the current. These results indicate famotidine does not directly affect the cardiac repolarization process.
Yuji
Y
Nakamura
Akira
A
Takahara
Atsushi
A
Sugiyama
D000200:Action Potentials / Q000187:drug effects*; D000818:Animals; D002460:Cell Line; D006224:Cricetinae; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D051638:Ether-A-Go-Go Potassium Channels / Q000187:drug effects*; D015738:Famotidine / Q000494:pharmacology*; D006168:Guinea Pigs; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D006801:Humans; D010210:Papillary Muscles / Q000378:metabolism; D013015:Sotalol / Q000494:pharmacology
D051638:Ether-A-Go-Go Potassium Channels; D006635:Histamine H2 Antagonists; D015738:Famotidine; D013015:Sotalol; D004121:Dimethyl Sulfoxide