Inflammation induced by Bothrops asper venom.
Inflammation is a major characteristic of envenomation by snakes from viperine and crotaline species. Bothrops asper snake venom elicits, among other alterations, a pronounced inflammatory response at the site of injection both in humans and experimental animals. This review describes the current status of our understanding of the inflammatory reaction, including pain, triggered by B. asper venom. The experimental studies on the action of this venom as well as the complex network of chemical mediators involved are summarized. Moreover, aspects of the molecular mechanisms orchestrating this important response to envenomation by B. asper are presented. Considering that isolated toxins are relevant tools for understanding the actions of the whole venom, studies dealing with the mechanisms of inflammatory and nociceptive properties of phospholipases A2, a metalloproteinase and serine proteinases isolated from B. asper venom are also described.
Laboratório de Farmacologia, Instituto Butantan, CEP 05503-900 Sao Paulo, Brazil. cteixeir@usp.br
Catarina
C
Teixeira
Yara
Y
Cury
Vanessa
V
Moreira
Gisele
G
Picolob
Fernando
F
Chaves
D000818:Animals; D017837:Bothrops; D003435:Crotalid Venoms / Q000633:toxicity*; D007249:Inflammation / Q000209:etiology* / Q000503:physiopathology; D018836:Inflammation Mediators / Q000502:physiology; D010146:Pain / Q000209:etiology; D012909:Snake Bites / Q000503:physiopathology*
D003435:Crotalid Venoms; D018836:Inflammation Mediators