Oxysterols drive dopaminergic neurogenesis from stem cells.
Stem cell therapy for Parkinson's disease requires effective production of dopaminergic neurons. In this issue of Cell Stem Cell, Sacchetti et al. (2009) report an unexpected role of liver X receptors and their ligand, oxysterols, in regulating dopaminergic neurogenesis.
Ma
Dengke K
DK
Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21209, USA.
Ming
Guo-li
GL
Song
Hongjun
H
D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D002784:Cholesterol / Q000031:analogs & derivatives* / Q000494:pharmacology*; D004298:Dopamine / Q000378:metabolism*; D053595:Embryonic Stem Cells / Q000166:cytology / Q000187:drug effects*; D006801:Humans; D000071518:Liver X Receptors; D008636:Mesencephalon / Q000166:cytology* / Q000187:drug effects; D051379:Mice; D055495:Neurogenesis / Q000187:drug effects* / Q000235:genetics; D057093:Orphan Nuclear Receptors / Q000235:genetics / Q000502:physiology
D000071518:Liver X Receptors; D057093:Orphan Nuclear Receptors; D002784:Cholesterol; D004298:Dopamine