Efficient synthesis of nevirapine analogs to study its metabolic profile by click fishing.
Knowledge of the biotransformation and pharmacokinetics of the antiretroviral agent nevirapine is still insufficient. In order to trace rash inducing metabolites of nevirapine, we devised a short and efficient multi-gram synthesis of a nevirapine analog that can be coupled to azide containing compounds by click chemistry.
Bernard
Sylvain
S
Département de Chimie, Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, 3001 12e Avenue nord, Sherbrooke, Québec, Canada J1H 5N4.
Defoy
Daniel
D
Dory
Yves L
YL
Klarskov
Klaus
K
D000818:Animals; D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D018360:Crystallography, X-Ray; D003500:Cyclization; D006801:Humans; D008968:Molecular Conformation; D019829:Nevirapine / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D051381:Rats
D019380:Anti-HIV Agents; D019829:Nevirapine