Substantiating in vivo magnetic brain tumor targeting of cationic iron oxide nanocarriers via adsorptive surface masking.
Cationic magnetic nanoparticles are attractive as potential vehicles for tumor drug delivery due to their favorable interactions with both the tumor milieu and the therapeutic cargo. However, systemic delivery of these nanoparticles to the tumor site is compromised by their rapid plasma clearance. We developed a simple method for in vivo protection of cationic nanocarriers, using non-covalent surface masking with a conjugate of low molecular weight heparin and polyethylene glycol. Surface masking resulted in a 11-fold increase in plasma AUC and a 2-fold increase in the magnetic capture of systemically injected nanoparticles in orthotopic rodent brain tumors. Overall, the described methodology could expand the prospective applications for cationic magnetic nanoparticles in magnetically mediated gene/drug delivery.
Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA.
Beata
B
Chertok
Allan E
AE
David
Bradford A
BA
Moffat
Victor C
VC
Yang
D000327:Adsorption; D000818:Animals; D001932:Brain Neoplasms / Q000188:drug therapy*; D002412:Cations / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D004337:Drug Carriers / Q000627:therapeutic use*; D005290:Ferric Compounds / Q000627:therapeutic use*; D008280:Magnetics; D008297:Male; D009368:Neoplasm Transplantation; D051381:Rats; D011916:Rats, Inbred F344; D013499:Surface Properties
D002412:Cations; D004337:Drug Carriers; D005290:Ferric Compounds; C000499:ferric oxide