Sirtuin regulation in calorie restriction.
The beneficial effects of calorie restriction diet in extending lifespan and preventing diseases have long been recognized. Recent genetic and molecular studies in model organisms began to uncover the molecular regulation of calorie restriction response, with the gene SIR2 playing an essential role. This article summarizes the latest development on how mammalian SIR2 homologs coordinately regulate the calorie restriction response.
Department of Nutritional Sciences & Toxicology, University of California, Berkeley, CA 94720, USA.
Xiaolei
X
Qiu
Katharine V
KV
Brown
Yehu
Y
Moran
Danica
D
Chen
D000375:Aging / Q000235:genetics / Q000378:metabolism; D000818:Animals; D031204:Caloric Restriction; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D008136:Longevity / Q000235:genetics / Q000502:physiology*; D008928:Mitochondria / Q000378:metabolism; D008954:Models, Biological; D009369:Neoplasms / Q000517:prevention & control; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism; D056564:Sirtuin 1 / Q000235:genetics / Q000378:metabolism; D056565:Sirtuin 2 / Q000235:genetics / Q000378:metabolism; D037761:Sirtuins / Q000235:genetics / Q000378:metabolism*
D056564:Sirtuin 1; D056565:Sirtuin 2; D037761:Sirtuins