The effect of tanshinone IIA on renal and liver functions in ovine fetuses in utero.
This was the first study in determination of the effects of the herbal medicine, danshen, on fetal hepatic and renal functions in utero. Tanshinone IIA, an active ingredient of danshen, was tested in the experimental fetal model. Three doses (20, 40, or 80 mg) of tanshinone IIA and 0.9% NaCl (as the control) were intravenously (i.v.) administrated into pregnant ewes. Both maternal and fetal blood samples were collected and analyzed for renal and liver functions by examining the enzymes and renal excretion. The results showed that tanshinone IIA did not alter fetal urine volume, urine electrolytes, and osmolality. Enzyme activities related to the hepatic and renal functions were not changed. In addition, maternal application of tanshinone IIA had no effect of maternal and fetal lipid profile. The results demonstrated that tanshinone IIA used during the last third of gestation did not cause the biochemical changes related to renal and liver functions in both the mother and fetus. This provides new information to guide the use of herbal medicine during pregnancy.
Zhang
Yifan
Y
Perinatal Biology Center, Soochow University First Affiliated Hospital, Suzhou, China.
Can
Rui
R
Mao
Caiping
C
Zhang
Yuying
Y
Zhu
Liyan
L
Shao
Huan
H
Wang
Liping
L
Wang
Aiqing
A
Xu
Zhice
Z
D045784:Abietanes; D000818:Animals; D004365:Drugs, Chinese Herbal / Q000494:pharmacology; D005260:Female; D005333:Fetus / Q000187:drug effects / Q000502:physiology; D051657:KCNQ1 Potassium Channel / Q000378:metabolism; D007668:Kidney / Q000187:drug effects* / Q000201:enzymology; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology; D010616:Phenanthrenes / Q000494:pharmacology*; D010618:Phenanthrolines / Q000494:pharmacology; D011247:Pregnancy; D011270:Pregnancy, Animal; D027561:Salvia miltiorrhiza / Q000737:chemistry*; D012756:Sheep; D014599:Uterus / Q000187:drug effects* / Q000502:physiology
D045784:Abietanes; D004365:Drugs, Chinese Herbal; D051657:KCNQ1 Potassium Channel; D010616:Phenanthrenes; D010618:Phenanthrolines; C021751:tanshinone; C028972:dan-shen root extract