Low pH does not modulate antioxidant status of diphenyl ditelluride but exacerbates Fe (II)-induced lipid peroxidation in liver preparation.
The relationship of acidosis and lipid peroxidation in liver homogenate was studied and the effect of pH on the antioxidant potential of diphenyl ditelluride is reported. Low pH increased the rate of lipid peroxidation both in the absence and presence of Fe (II), while diphenyl ditelluride (DPDT) inhibited the rate of lipid peroxidation in a concentration-dependent manner at all studied pH values. However, the change in pH did not alter the antioxidant activity of the compound. This study shows acidosis catalyzed oxidative stress in liver homogenate and the antioxidant potential of diphenyl ditelluride.
Hassan
Waseem
W
Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, Brazil. waseem_anw@yahoo.com
Ibrahim
Mohammad
M
Rocha
Joao B T
JB
D000138:Acidosis; D000818:Animals; D000975:Antioxidants / Q000737:chemistry*; D001555:Benzene Derivatives / Q000737:chemistry*; D016166:Free Radical Scavengers / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D015227:Lipid Peroxidation; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects; D009942:Organometallic Compounds / Q000737:chemistry*; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013438:Sulfhydryl Compounds / Q000737:chemistry; D013691:Tellurium / Q000737:chemistry*
D000975:Antioxidants; D001555:Benzene Derivatives; D016166:Free Radical Scavengers; D009942:Organometallic Compounds; D013438:Sulfhydryl Compounds; C434247:diphenylditelluride; D013691:Tellurium