EMMA--mouse mutant resources for the international scientific community.
The laboratory mouse is the premier animal model for studying human disease and thousands of mutants have been identified or produced, most recently through gene-specific mutagenesis approaches. High throughput strategies by the International Knockout Mouse Consortium (IKMC) are producing mutants for all protein coding genes. Generating a knock-out line involves huge monetary and time costs so capture of both the data describing each mutant alongside archiving of the line for distribution to future researchers is critical. The European Mouse Mutant Archive (EMMA) is a leading international network infrastructure for archiving and worldwide provision of mouse mutant strains. It operates in collaboration with the other members of the Federation of International Mouse Resources (FIMRe), EMMA being the European component. Additionally EMMA is one of four repositories involved in the IKMC, and therefore the current figure of 1700 archived lines will rise markedly. The EMMA database gathers and curates extensive data on each line and presents it through a user-friendly website. A BioMart interface allows advanced searching including integrated querying with other resources e.g. Ensembl. Other resources are able to display EMMA data by accessing our Distributed Annotation System server. EMMA database access is publicly available at http://www.emmanet.org.
Wilkinson
Phil
P
European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Sengerova
Jitka
J
Matteoni
Raffaele
R
Chen
Chao-Kung
CK
Soulat
Gaetan
G
Ureta-Vidal
Abel
A
Fessele
Sabine
S
Hagn
Michael
M
Massimi
Marzia
M
Pickford
Karen
K
Butler
Richard H
RH
Marschall
Susan
S
Mallon
Ann-Marie
AM
Pickard
Amanda
A
Raspa
Marcello
M
Scavizzi
Ferdinando
F
Fray
Martin
M
Larrigaldie
Vanessa
V
Leyritz
Johan
J
Birney
Ewan
E
Tocchini-Valentini
Glauco P
GP
Brown
Steve
S
Herault
Yann
Y
Montoliu
Lluis
L
de Angelis
Martin Hrabé
MH
Smedley
Damian
D
D000818:Animals; D002875:Chromosomes; D019295:Computational Biology / Q000379:methods* / Q000639:trends; D030541:Databases, Genetic; D030561:Databases, Nucleic Acid; D030562:Databases, Protein; D016247:Information Storage and Retrieval / Q000379:methods; D020407:Internet; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008957:Models, Genetic; D017434:Protein Structure, Tertiary; D012984:Software; D014584:User-Computer Interface