Does magnetic resonance imaging accurately predict residual disease in breast cancer?
BACKGROUND
The accuracy of magnetic resonance imaging (MRI) in identifying residual disease after breast conservation therapy (BCT) is unclear.


METHODS
Review of an institutional database identified patients with positive or close (<or=2 mm) margins undergoing MRI before re-excision. Histopathologic correlation was performed.


RESULTS
Forty-three women underwent MRI after BCT. MRI suggested residual disease in 29 patients, of whom 20 (69%) had residual carcinoma pathologically. Nine patients had false-positive MRI as seen by benign pathology findings. Fourteen MRIs indicated no residual disease, of which 6 had residual disease pathologically. The sensitivity and positive predictive value of MRI was 77% and 69%, respectively. MRI conducted within 28 days of the original surgery was 85% sensitive. MRI performed after 28 days was 69% sensitive.


CONCLUSIONS
MRI is able to detect residual disease among most patients undergoing re-excision. False-positive results may be caused by inflammatory processes that resemble residual disease.
Stucky
Chee-Chee H
CC
Department of Surgery, Mayo Clinic, 5777 E. Mayo Blvd., Phoenix, AZ 85054, USA. stucky.cheechee@mayo.edu
McLaughlin
Sarah A
SA
Dueck
Amylou C
AC
Gray
Richard J
RJ
Giurescu
Marina E
ME
Carpenter
Susanne G
SG
Grimsby
Gwen M
GM
Apsey
Heidi A
HA
Pockaj
Barbara A
BA
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000601:surgery; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D015412:Mastectomy, Segmental; D008875:Middle Aged; D018365:Neoplasm, Residual / Q000175:diagnosis*; D011237:Predictive Value of Tests