Correlation of high and decreased NY-ESO-1 immunity to spontaneous regression and subsequent recurrence in a lung cancer patient.
We show correlation between strong and decreased NY-ESO-1-specific immunity with spontaneous regression and subsequent recurrence, respectively, in a long-surviving patient with an NY-ESO-1-expressing lung adenocarcinoma. An integrated immune response consisting of IgG antibody, as well as CD4 and CD8 T cells, against NY-ESO-1 was observed at the time of spontaneous regression of multiple pleural metastases. After tumor dormancy for 3 years, the tumor started to progress. IgG antibody levels and the number of CD4 and CD8 T cells against NY-ESO-1 decreased, but were still detectable. On the other hand, the number of Foxp3+ CD25 high T regulatory cells gradually increased. The findings suggest the relevance of the NY-ESO-1 immune response and its regulation by Foxp3+ CD25 high T regulatory cells in the clinical course of this lung cancer patient.
Department of Immunology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Midori
M
Isobe
Shingo
S
Eikawa
Akiko
A
Uenaka
Yoichi
Y
Nakamura
Tetsuo
T
Kanda
Shigeru
S
Kohno
Kiyotaka
K
Kuzushima
Eiichi
E
Nakayama
D000230:Adenocarcinoma / Q000276:immunology* / Q000378:metabolism / Q000503:physiopathology / Q000556:secondary; D000368:Aged; D000951:Antigens, Neoplasm / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D000939:Epitopes; D051858:Forkhead Transcription Factors / Q000096:biosynthesis; D006801:Humans; D007109:Immunity; D007074:Immunoglobulin G / Q000378:metabolism; D053645:Interleukin-2 Receptor alpha Subunit / Q000096:biosynthesis; D008175:Lung Neoplasms / Q000276:immunology* / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D008297:Male; D008565:Membrane Proteins / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D009364:Neoplasm Recurrence, Local; D009365:Neoplasm Regression, Spontaneous / Q000276:immunology*; D010997:Pleural Neoplasms / Q000276:immunology* / Q000378:metabolism / Q000503:physiopathology / Q000556:secondary; D037182:T-Cell Antigen Receptor Specificity; D050378:T-Lymphocytes, Regulatory / Q000276:immunology / Q000378:metabolism / Q000473:pathology
D000951:Antigens, Neoplasm; C104948:CTAG1B protein, human; D000939:Epitopes; C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors; D007074:Immunoglobulin G; D053645:Interleukin-2 Receptor alpha Subunit; D008565:Membrane Proteins