The evolution of an inflammatory response.
BACKGROUND
The past 25 years have witnessed immense progress in our understanding of the systemic, tissue-specific, and cellular consequences of severe injury and infection. Despite such insights, considerable controversy remains regarding appropriate biologic and management interventions to prevent or ameliorate the associated adverse outcomes.


METHODS
A review of several scientific developments arising from studies initiated at Cornell University Medical College during the tenure of Dr. G. Tom Shires. The implications of those and subsequent studies are discussed.


RESULTS
An understanding of patient-specific variation and adaptability could direct individualized biologic and management interventions for severe injury and infection.


CONCLUSIONS
Despite more detailed appreciation of the molecular mechanisms of danger and pathogen recognition and response biology, we have much to learn about the complexity of severe injury and infection. There is a great need to extend our investigation of these mechanisms to experimental and stress-modified clinical scenarios.
Department of Surgery, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, New Jersey 08901, USA. lowrysf@umdnj.edu
Stephen F
SF
Lowry
D000368:Aged; D005260:Female; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000503:physiopathology / Q000628:therapy; D008297:Male; D014947:Wounds and Injuries / Q000276:immunology / Q000503:physiopathology / Q000628:therapy