The role of integrins in cancer and the development of anti-integrin therapeutic agents for cancer therapy.
Integrins have been reported to mediate cell survival, proliferation, differentiation, and migration programs. For this reason, the past few years have seen an increased interest in the implications of integrin receptors in cancer biology and tumor cell aggression. This review considers the potential role of integrins in cancer and also addresses why integrins are present attractive targets for drug design. It discusses of the several properties of the integrin-based chemotherapeutic agents currently under consideration clinically and provides an insight into cancer drug development using integrin as a target.
Thrombosis Research Institute, Manresa Road, London, SW3 6LR U.K.
Xinjie
X
Lu
Dong
D
Lu
Mike
M
Scully
Vijay
V
Kakkar