[Numerical modeling of mutual synchronization of self-oscillations of the epidermal proliferative activity in lesions of psoriatic skin].
The results of numerical modeling of mutual synchronization of self-oscillations of epidermal hyperproliferation in foci of lesions in psoriasis are presented. It is shown that this phenomenon enables one to explain some facts of development of the disease such as: (1) figured arrangement of pathological elements; (2) unexpected exacerbation of the process a short time after the treatment; (3) persistence of lesions in a limited region of the skin or, vice versa, their fast distribution throughout the surface of the body of a patient.
Laptev
M V
MV
Nikulin
N K
NK
D000818:Animals; D001683:Biological Clocks; D049109:Cell Proliferation; D004817:Epidermis / Q000503:physiopathology*; D006801:Humans; D008954:Models, Biological; D011565:Psoriasis / Q000503:physiopathology*