The role of PLZF in human myeloid development.
Little is known of the molecular regulators that enable production of large numbers of mature human hematopoietic cells ( approximately 10(12) cells daily) while at the same time ensuring that the progenitor pools are not depleted. At the same time, the system must remain sufficiently flexible to respond to conditions of increased cellular output such as during blood loss or infection. We have identified a key role for the transcription factor PLZF in both these processes.
Dick
John E
JE
Division of Cell and Molecular Biology, University Health Network, Toronto, Ontario, Canada. jdick@uhnres.utoronto.ca
Doulatov
Sergei
S
D006410:Hematopoiesis / Q000235:genetics*; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006801:Humans; D051741:Kruppel-Like Transcription Factors / Q000235:genetics / Q000502:physiology*; D022423:Myeloid Cells / Q000166:cytology*; D000075722:Promyelocytic Leukemia Zinc Finger Protein
D051741:Kruppel-Like Transcription Factors; D000075722:Promyelocytic Leukemia Zinc Finger Protein; C092037:ZBTB16 protein, human