Comparison of lateral flow technology and galactomannan and (1->3)-beta-D-glucan assays for detection of invasive pulmonary aspergillosis.
We compared a lateral flow device to galactomannan and (1-->3)-beta-D-glucan assays to detect invasive aspergillosis in an established guinea pig model of pulmonary disease. The lateral flow device became positive earlier (day 3) than the (1-->3)-beta-D-glucan and galactomannan assays (day 5), with all samples positive by each assay on day 7.
University of Texas at Austin College of Pharmacy, Austin, Texas, USA. wiederholdn@uthscsa.edu
Nathan P
NP
Wiederhold
Christopher R
CR
Thornton
Laura K
LK
Najvar
William R
WR
Kirkpatrick
Rosie
R
Bocanegra
Thomas F
TF
Patterson
D000818:Animals; D000946:Antigens, Fungal / Q000032:analysis* / Q000276:immunology; D001230:Aspergillus / Q000276:immunology / Q000302:isolation & purification*; D015415:Biomarkers / Q000032:analysis; D002853:Chromatography, Liquid / Q000295:instrumentation; D005690:Galactose / Q000031:analogs & derivatives; D006168:Guinea Pigs; D007118:Immunoassay / Q000295:instrumentation; D055744:Invasive Pulmonary Aspergillosis / Q000175:diagnosis* / Q000276:immunology; D008297:Male; D008351:Mannans / Q000032:analysis* / Q000276:immunology; D019095:Point-of-Care Systems; D011509:Proteoglycans; D012680:Sensitivity and Specificity; D047071:beta-Glucans / Q000032:analysis* / Q000276:immunology
D000946:Antigens, Fungal; D015415:Biomarkers; D008351:Mannans; D011509:Proteoglycans; D047071:beta-Glucans; C012990:galactomannan; C010770:polysaccharide-K; D005690:Galactose