Beta-amidoaldehydes via oxazoline hydroformylation.
4-Substituted oxazolines, which are readily synthesized from naturally occurring alpha-amino acids, are converted efficiently and stereospecifically to beta-amidoaldehydes in the presence of synthesis gas and catalytic dicobalt octacarbonyl.
Laitar
David S
DS
Department of Chemistry and Chemical Biology, Baker Laboratory, Cornell University, Ithaca, NY 14853-1301, USA.
Kramer
John W
JW
Whiting
Bryan T
BT
Lobkovsky
Emil B
EB
Coates
Geoffrey W
GW
D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D003035:Cobalt / Q000737:chemistry; D005740:Gases / Q000737:chemistry; D008968:Molecular Conformation; D010080:Oxazoles / Q000737:chemistry*; D013237:Stereoisomerism
D000447:Aldehydes; D005740:Gases; D010080:Oxazoles; D003035:Cobalt; C529955:dicobalt octacarbonyl