Allopurinol-induced DRESS syndrome in an adolescent patient.
A 16-year-old male patient, with a history of essential hypertension enrolled in an experimental drug protocol using allopurinol, presented to our emergency department with a 10-day history of fever. Initial laboratory evaluation revealed leukocytosis, eosinophilia, and transaminitis. After extensive work-up and exclusion of infectious and oncologic etiologies, the diagnosis of allopurinol-induced drug reaction and eosinophilia with systemic symptoms syndrome was carried out. The patient responded to administration of IV methylprednisolone, with complete resolution of symptoms and improvement of laboratory abnormalities. This case represents the first report of allopurinol-induced drug reaction and eosinophilia with systemic symptoms syndrome in a pediatric patient.
Dewan
Ashvin K
AK
Department of Pediatrics, Baylor College of Medicine, Division of Emergency Medicine, Texas Children's Hospital, Houston, Texas 77030, USA.
Quinonez
Ricardo A
RA
D000293:Adolescent; D000493:Allopurinol / Q000008:administration & dosage / Q000009:adverse effects*; D003875:Drug Eruptions / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D004802:Eosinophilia / Q000139:chemically induced / Q000175:diagnosis* / Q000188:drug therapy; D005334:Fever / Q000139:chemically induced / Q000175:diagnosis / Q000188:drug therapy; D006074:Gout Suppressants / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007964:Leukocytosis / Q000139:chemically induced / Q000175:diagnosis* / Q000188:drug therapy; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D013577:Syndrome; D000637:Transaminases / Q000097:blood
D006074:Gout Suppressants; D000493:Allopurinol; D000637:Transaminases; D008775:Methylprednisolone