[Tuberculous spondylitis in children and adolescents: results of treatment].
The results of treatment for tuberculous spondylitis were studied in 160 children and adolescents receiving different chemotherapy regimens and in 145 after application of the currently available surgical methods. When an individual regimen was used in 1990-2000, recovery was achieved in 90.8 +/- 2.9% of cases; recurrent vertebral processes were observed in 7.1 +/- 2.5%. With the routine regimen, controlled treatment was terminated in 81.0 +/- 5.2% of cases and the number of recurrent vertebral processes was increased by 11.8 +/- 4.6%. With the DOTS-Plus regimen, treatment was completed in 91.0 +/- 4.1% of cases. Mycobacterium tuberculosis cultures were isolated from postoperative biopsy specimens in 6.8 +/- 3.5% of the 154 operated patients. The author presents the results of reconstructive operations using a free-pedicle autograft and a myovascular graft. In the late period, the operated vertebral portion was fixed to form a bone block in 83.3 +/- 5.6 to 88.0 +/- 7.9% of cases. There was an increase in spinal deformity in patients with a disseminated vertebral process.
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Amanzholova
D000293:Adolescent; D000995:Antitubercular Agents / Q000627:therapeutic use*; D001706:Biopsy; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008159:Lumbar Vertebrae; D008297:Male; D009169:Mycobacterium tuberculosis / Q000302:isolation & purification; D012189:Retrospective Studies; D013123:Spinal Fusion / Q000379:methods*; D013166:Spondylitis / Q000175:diagnosis / Q000382:microbiology / Q000628:therapy*; D013904:Thoracic Vertebrae; D016896:Treatment Outcome; D014399:Tuberculosis, Spinal / Q000175:diagnosis / Q000382:microbiology / Q000628:therapy*
D000995:Antitubercular Agents