[The occurrence of human papillomavirus--HPV in the biopsies from colon polyps and cancer].
Human papillomaviruses (HPV) infection can be associated with benign (warts) and malignant (precancer and cancer) genital, perianal and oral lesions. The role of HPV in the pathogenesis of colonorectal cancer and adenomas is still undetermined. We investigated the occurrence of nononcogenic HPV 6/11 and oncogenic 16/18 DNA in colon cancer, polyps and normal tissue using PCR. HPV 16/18 were detected more frequently in colon cancers (67%) and adenomas (56%) than in normal colon mucosa (28%). In case of HPV 6/11 the differences were not significant. The results suggest the possible role of HPV 16/18 in pathogenesis of colon cancers and polyps.
Katedra i Klinika Dermatologii i Wenerologii Warszawskiego Uniwersytetu Medycznego.
Beata
B
Młynarczyk
Magdalena
M
Malejczyk
Jacek
J
Muszyński
Sławomir
S
Majewski
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D003110:Colonic Neoplasms / Q000473:pathology / Q000821:virology*; D003111:Colonic Polyps / Q000473:pathology / Q000821:virology*; D005260:Female; D052140:Human papillomavirus 11 / Q000302:isolation & purification*; D052162:Human papillomavirus 16 / Q000302:isolation & purification*; D052161:Human papillomavirus 18 / Q000302:isolation & purification*; D052163:Human papillomavirus 6 / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged