Correlation between HIV-1 seropositivity and prevalence of a gamma-secretase polymorphism in two distinct ethnic populations.
Susceptibility for human immunodeficiency virus type 1 (HIV-1) infection may be influenced by host genetics. Recent findings with a Wistar rat model raised the possibility that the gamma-secretase pathway may be associated with an individual's susceptibility to infection. A functional single-nucleotide polymorphism (SNP) in the gamma-secretase component APH1B (Phe217Leu; rs1047552) was therefore analyzed for association with HIV-1 infection. The SNP showed a tendency for association with HIV-1 infection in a Xhosa indigenous South African Bantu study (P = 0.087), and associated significantly in a Caucasian Dutch study (P = 0.049). Together, the results suggest a role for the gamma-secretase pathway in susceptibility to HIV-1 infection.
Department of Molecular Animal Physiology, Radboud University Nijmegen, Donders Institute for Brain, Cognition and Behaviour and Nijmegen Center for Molecular Life Sciences, Nijmegen 6525 GA , The Netherlands.
Karen M J
KM
van Loo
Jessica E
JE
van Schijndel
Martine
M
van Zweeden
Daniëlle
D
van Manen
Mieke D
MD
Trip
Desiree C
DC
Petersen
Hanneke
H
Schuitemaker
Vanessa M
VM
Hayes
Gerard J M
GJ
Martens
D019943:Amino Acid Substitution / Q000235:genetics; D053829:Amyloid Precursor Protein Secretases / Q000235:genetics*; D004198:Disease Susceptibility; D010450:Endopeptidases; D005260:Female; D015658:HIV Infections / Q000235:genetics*; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D020125:Mutation, Missense; D010447:Peptide Hydrolases / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
D008565:Membrane Proteins; C475155:APH1B protein, human; D053829:Amyloid Precursor Protein Secretases; D010450:Endopeptidases; D010447:Peptide Hydrolases