Nonasthmatic nasal polyposis patients with allergy exhibit greater epithelial MMP positivity.
OBJECTIVE
To determine the influence of allergic rhinitis (AR) on the expression of matrix metalloproteinase (MMP)-9, MMP-2, and tissue inhibitor-1 of metalloproteinase (TIMP-1) in nasal polyposis.


METHODS
A case-control study.


METHODS
A tertiary referral center.


METHODS
The expression of MMP-9, MMP-2, and TIMP-1 was investigated in the nasal polyp tissue (NP) and maxillary sinus mucosa (MM) samples from 20 AR patients and 20 nonallergic patients undergoing endoscopic sinus surgery. Trichrome, periodic acid-Schiff, and hematoxylin-eosin staining were also performed and those expression levels were compared.


RESULTS
Infiltration of eosinophils was shown more intensely in NP rather than in MM, especially in the presence of AR. In the NP of AR patients, increased expression of MMP-9, MMP-2, and TIMP-1 was observed more prominently than in that of the control group. In case of MM, however, there was no significant difference between AR patients and the control group.


CONCLUSIONS
The presence of AR may enhance the expression of MMP-9, MMP-2, and TIMP-1 associated with airway remodeling in nasal polyposis.
Shin
Hyun-Woo
HW
Department of Otorhinolaryngology, Seoul National University College of Medicine, Seoul, Korea.
Han
Doo Hee
DH
Lim
Yune Sung
YS
Kim
Hye Jung
HJ
Kim
Dong-Young
DY
Lee
Chul Hee
CH
Min
Yang-Gi
YG
Rhee
Chae-Seo
CS
D000293:Adolescent; D000328:Adult; D000368:Aged; D006801:Humans; D007150:Immunohistochemistry; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism; D008443:Maxillary Sinus; D008875:Middle Aged; D009297:Nasal Mucosa / Q000201:enzymology* / Q000378:metabolism / Q000473:pathology; D009298:Nasal Polyps / Q000150:complications / Q000201:enzymology* / Q000473:pathology; D012221:Rhinitis, Allergic, Perennial / Q000150:complications*; D006255:Rhinitis, Allergic, Seasonal / Q000150:complications*; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000378:metabolism; D055815:Young Adult
D019715:Tissue Inhibitor of Metalloproteinase-1; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9