Managing mother-to-child transmission of HIV infection in developed-country settings.
This article reviews current understanding of the management of mother-to-child transmission of HIV-1 infection in the context of developed-country settings. The advent of highly active antiretroviral therapy has facilitated the virtual elimination of mother-to-child transmission of HIV infection in developed countries, reducing transmission rates to approximately 1-2%. This review describes the epidemiology of HIV infection among women of child-bearing age and the risk factors, timing and mechanisms of mother-to-child transmission, followed by a discussion of the identification of pregnant HIV-infected women and their therapeutic and obstetric management.
Thorne
Claire
C
Institute of Child Health, Centre for Paediatric Epidemiology and Biostatistics, 30 Guilford Street, London,WC1N 1EH, UK. c.thorne@ich.ucl.ac.uk.
Newell
Marie-Louise
ML