Lymphotoxins: new targets for hepatocellular carcinoma.
In this issue of Cancer Cell, Haybaeck et al. unravel the role of lymphotoxin pathway in the development of hepatocellular carcinoma (HCC). Aberrant activation of this cascade in mice livers recapitulates the stages of fibrosis and inflammation that precedes human liver cancer, providing a novel family of potential therapeutic targets.
HCC Translational Research Laboratory, Barcelona-Clinic Liver Cancer Group, Liver Unit. Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Hospital Clinic, BCN 08036, Barcelona, Spain.
Augusto
A
Villanueva
Radoslav
R
Savic
Josep M
JM
Llovet
D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism; D006528:Carcinoma, Hepatocellular / Q000235:genetics / Q000276:immunology* / Q000821:virology; D002472:Cell Transformation, Viral; D016207:Cytokines / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D019694:Hepatitis B, Chronic / Q000276:immunology*; D019698:Hepatitis C, Chronic / Q000276:immunology*; D022781:Hepatocytes / Q000276:immunology / Q000821:virology; D006801:Humans; D008099:Liver / Q000276:immunology / Q000821:virology; D008113:Liver Neoplasms / Q000235:genetics / Q000276:immunology* / Q000821:virology; D008214:Lymphocytes / Q000276:immunology / Q000821:virology; D053259:Lymphotoxin beta Receptor / Q000235:genetics / Q000378:metabolism*; D008233:Lymphotoxin-alpha / Q000235:genetics / Q000378:metabolism*; D053308:Lymphotoxin-beta / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D015398:Signal Transduction; D015854:Up-Regulation
D014408:Biomarkers, Tumor; D016207:Cytokines; D053259:Lymphotoxin beta Receptor; D008233:Lymphotoxin-alpha; D053308:Lymphotoxin-beta