Salmonella--the ultimate insider. Salmonella virulence factors that modulate intracellular survival.
Salmonella enterica serovar Typhimurium is a common facultative intracellular pathogen that causes food-borne gastroenteritis in millions of people worldwide. Intracellular survival and replication are important virulence determinants and the bacteria can be found in a variety of phagocytic and non-phagocytic cells in vivo. Invasion of host cells and intracellular survival are dependent on two type III secretion systems, T3SS1 and T3SS2, each of which translocates a distinct set of effector proteins. However, other virulence factors including ion transporters, superoxide dismutase, flagella and fimbriae are also involved in accessing and utilizing the intracellular niche.
Laboratory of Intracellular Parasites, NIAID, NIH, Rocky Mountain Laboratories, Hamilton, MT, USA.
J Antonio
JA
Ibarra
Olivia
O
Steele-Mortimer
D001426:Bacterial Proteins / Q000502:physiology*; D003593:Cytoplasm / Q000382:microbiology*; D054884:Host-Pathogen Interactions; D006801:Humans; D050296:Microbial Viability; D012486:Salmonella typhimurium / Q000472:pathogenicity* / Q000502:physiology*; D037521:Virulence Factors / Q000502:physiology*
D001426:Bacterial Proteins; D037521:Virulence Factors