Decreased cellular IL-23 but not IL-17 production in children with autism spectrum disorders.
A potential role for T(H)17 cells has been suggested in a number of conditions including neurodevelopmental disorders such as autism spectrum disorders (ASD). In the current study, we investigated cellular release of IL-17 and IL-23 following an in-vitro immunological challenge of peripheral blood mononuclear cells (PBMC) from children with ASD compared to age-matched typically developing controls. Following stimulation, the concentration of IL-23, but not IL-17, was significantly reduced (p=0.021) in ASD compared to controls. Decreased cellular IL-23 production in ASD warrants further research to determine its role on the generation and survival of T(H)17 cells, a cell subset important in neuroinflammatory conditions that may include ASD.
Department of Medical Microbiology and Immunology, University of California at Davis, USA. pashwood@ucdavis.edu
Charity
C
Onore
Amanda
A
Enstrom
Paula
P
Krakowiak
Irva
I
Hertz-Picciotto
Robin
R
Hansen
Judy
J
Van de Water
Paul
P
Ashwood
D001321:Autistic Disorder / Q000276:immunology* / Q000378:metabolism* / Q000503:physiopathology; D015415:Biomarkers / Q000378:metabolism; D002478:Cells, Cultured; D002675:Child, Preschool; D015536:Down-Regulation / Q000187:drug effects / Q000276:immunology; D004660:Encephalitis / Q000150:complications / Q000276:immunology / Q000503:physiopathology; D005260:Female; D006801:Humans; D020381:Interleukin-17 / Q000378:metabolism*; D053759:Interleukin-23 / Q000378:metabolism*; D007963:Leukocytes, Mononuclear / Q000276:immunology* / Q000378:metabolism*; D008297:Male; D009483:Neuropsychological Tests; D010835:Phytohemagglutinins / Q000276:immunology / Q000494:pharmacology; D012919:Social Behavior; D012920:Social Behavior Disorders / Q000175:diagnosis / Q000276:immunology; D011795:Surveys and Questionnaires; D006377:T-Lymphocytes, Helper-Inducer / Q000187:drug effects / Q000276:immunology
D015415:Biomarkers; D020381:Interleukin-17; D053759:Interleukin-23; D010835:Phytohemagglutinins