Extended use dexamethasone-associated posterior reversible encephalopathy syndrome with cisplatin-based chemotherapy.
We describe a normotensive patient who developed posterior reversible encephalopathy syndrome following prolonged use of dexamethasone for nausea control with cisplatin and pemetrexed chemotherapy. A 32-year-old woman with advanced intraperitoneal mesothelioma developed new-onset seizures and cognitive impairment. MRI of the brain demonstrated several areas of increased signal on T2-weighted and fluid-attenuated inversion recovery sequences within the subcortical white matter of both hemispheres. Chemotherapy was discontinued and dexamethasone tapered-off. She returned to her baseline with resolution of MRI abnormalities. We hypothesize that extended use of dexamethasone potentiated the relatively uncommon complication of leukotoxicity associated with cisplatin, and we elaborate on dexamethasone's contribution.
Nguyen
MyChau T
MT
Department of Pharmacy, The University of Illinois at Chicago, Chicago, Illinois, USA.
Virk
Irim Y
IY
Chew
Lita
L
Villano
J Lee
JL
D000328:Adult; D018931:Antineoplastic Agents, Hormonal / Q000009:adverse effects*; D002945:Cisplatin / Q000009:adverse effects*; D003907:Dexamethasone / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D009325:Nausea / Q000188:drug therapy; D054038:Posterior Leukoencephalopathy Syndrome / Q000139:chemically induced*
D018931:Antineoplastic Agents, Hormonal; D003907:Dexamethasone; D002945:Cisplatin