Levels of angiogenic factors in patients with multiple myeloma correlate with treatment response.
Angiogenesis plays a significant role in the pathogenesis of multiple myeloma (MM). We have measured concentrations of angiogenesis activators, including vascular endothelial growth factor (VEGF), basic fibroblast growth factor, and hepatocyte growth factor (HGF), and inhibitors, including endostatin, thrombospondin-1 (TSP-1), and angiostatin in the peripheral and bone marrow blood of MM patients at diagnosis and after high-dose chemotherapy. We have analyzed 96 patients with secretory MM. Serial measurements of angiogenesis factors/inhibitors were analyzed in the plasma by subgroups based on the best treatment response. Concentrations of angiogenic factors were determined in the peripheral blood and bone marrow plasma. There were significant decreases of VEGF and HGF levels and a significant increase in TSP-1 concentrations in the bone marrow plasma of patients who achieved complete or very good partial response in contrast to those who had partial or no response. VEGF and HGF levels decrease but those of TSP-1 increase after successful treatment for MM, indicating a reduction in the rate of angiogenesis.
Departement of Internal Medicine-Hematooncology, University Hospital Brno, Masaryk University, Brno, Czech Republic. lpour@fnbrno.cz
Ludek
L
Pour
Hana
H
Svachova
Zdenek
Z
Adam
Martina
M
Almasi
Lucie
L
Buresova
Tomas
T
Buchler
Lucie
L
Kovarova
Pavel
P
Nemec
Miroslav
M
Penka
Jiri
J
Vorlicek
Roman
R
Hajek
D000328:Adult; D000368:Aged; D043168:Angiostatins / Q000097:blood*; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D005260:Female; D017228:Hepatocyte Growth Factor / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy*; D019700:Thrombospondin 1 / Q000097:blood*; D016896:Treatment Outcome; D042461:Vascular Endothelial Growth Factor A / Q000097:blood*
D000970:Antineoplastic Agents; D019700:Thrombospondin 1; D042461:Vascular Endothelial Growth Factor A; D017228:Hepatocyte Growth Factor; D043168:Angiostatins