Antinucleosome antibodies in juvenile chronic arthritis.
A broad range of autoantibodies have been detected in juvenile chronic arthritis (JCA) patients, although, none of them can be considered specific for this entity. Antinuclear antibody (ANA) is routinely searched in these patients mainly because it is associated with uveitis, a comorbidity that is particularly frequent in the oligoarticular form. Nevertheless, the ANA specific antigen target in JCA is unknown. In this study, we aimed to search for antinucleosome antibodies in 30 adult JCA patients and to study possible associations with clinical profile. Ten individuals (33.3%) were positive for antinucleosome antibodies and seven (70%) were simultaneously ANA positive (p = 0.01). We did not find any significant association among antinucleosome and JCA form, uveitis, age of onset, gender, or functional index. We conclude that in JCA, there is a prevalence of 33.3% of antinucleosome antibodies. Further investigations are needed to understand the ANA positivity found in this disease as far as the clinical impact of this finding.
Renato M
RM
Nisihara
Thelma
T
Skare
Marilia Barreto
MB
Silva
Rafael Mourato
RM
Silva
Danilo J Munhoz
DJ
Silva
D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000974:Antibodies, Antinuclear / Q000097:blood*; D001171:Arthritis, Juvenile / Q000150:complications / Q000276:immunology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009707:Nucleosomes / Q000276:immunology*; D012720:Severity of Illness Index; D012737:Sex Factors; D014605:Uveitis / Q000150:complications / Q000276:immunology / Q000503:physiopathology; D055815:Young Adult
D000974:Antibodies, Antinuclear; D009707:Nucleosomes