Evaluation of the antiangiogenic, anti-inflammatory, and antinociceptive activities of morin.
Morin displayed significant inhibition of chick chorioallantoic membrane (CAM) angiogenesis and was able to increase the endostatin level in human umbilical vein endothelial cells (HUVECs). Morin was shown to contain an in vivo anti-inflammatory activity using a carrageenan-induced air pouch model in mice. Antinociceptive activity of morin was also assessed using an acetic acid-induced writhing test in mice. Collectively, morin possesses antiangiogenic, in vivo anti-inflammatory, and antinociceptive activities.
Jung
Hyun-Joo
HJ
Brain Korea 21 Project for Medical Science, Department of Anatomy, Yonsei University College of Medicine, Seoul, Korea.
Kim
Su-Jung
SJ
Song
Yun-Seon
YS
Park
Eun-Hee
EH
Lim
Chang-Jin
CJ
D019342:Acetic Acid; D000700:Analgesics / Q000494:pharmacology* / Q000627:therapeutic use; D020533:Angiogenesis Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001522:Behavior, Animal / Q000187:drug effects; D002351:Carrageenan; D002460:Cell Line; D002642:Chick Embryo; D049033:Chorioallantoic Membrane / Q000098:blood supply / Q000187:drug effects; D004195:Disease Models, Animal; D043169:Endostatins / Q000097:blood; D042783:Endothelial Cells / Q000187:drug effects / Q000378:metabolism; D005419:Flavonoids / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D007249:Inflammation / Q000188:drug therapy; D031624:Maclura / Q000737:chemistry; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010146:Pain / Q000188:drug therapy; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D031647:Psidium / Q000737:chemistry; D014471:Umbilical Veins; D047309:Flavones
D019342:Acetic Acid; D000700:Analgesics; D020533:Angiogenesis Inhibitors; D000893:Anti-Inflammatory Agents; D002351:Carrageenan; D043169:Endostatins; D005419:Flavonoids; D010936:Plant Extracts; C008548:morin; D047309:Flavones