Algorithm-based method for detection of blood vessels in breast MRI for development of computer-aided diagnosis.
OBJECTIVE
To develop a computer-based algorithm for detecting blood vessels that appear in breast dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI), and to evaluate the improvement in reducing the number of vascular pixels that are labeled by computer-aided diagnosis (CAD) systems as being suspicious of malignancy.


METHODS
The analysis was performed in 34 cases. The algorithm applied a filter bank based on wavelet transform and the Hessian matrix to detect linear structures as blood vessels on a two-dimensional maximum intensity projection (MIP). The vessels running perpendicular to the MIP plane were then detected based on the connectivity of enhanced pixels above a threshold. The nonvessel enhancements were determined and excluded based on their morphological properties, including those showing scattered small segment enhancements or nodular or planar clusters. The detected vessels were first converted to a vasculature skeleton by thinning and subsequently compared to the vascular track manually drawn by a radiologist.


RESULTS
When evaluating the performance of the algorithm in identifying vascular tissue, the correct-detection rate refers to pixels identified by both the algorithm and radiologist, while the incorrect-detection rate refers to pixels identified by only the algorithm, and the missed-detection rate refers to pixels identified only by the radiologist. From 34 analyzed cases the median correct-detection rate was 85.6% (mean 84.9% +/- 7.8%), the incorrect-detection rate was 13.1% (mean 15.1% +/- 7.8%), and the missed-detection rate was 19.2% (mean 21.3% +/- 12.8%). When detected vessels were excluded in the hot-spot color-coding of the CAD system, they could reduce the labeling of vascular vessels in 2.6%-68.6% of hot-spot pixels (mean 16.6% +/- 15.9%).


CONCLUSIONS
The computer algorithm-based method can detect most large vessels and provide an effective means in reducing the labeling of vascular pixels as suspicious on a DCE-MRI CAD system. This algorithm may improve the workflow of radiologists using CAD for image display, but will be particularly useful for development of automated CAD that gives diagnostic impression.
Tu & Yuen Center for Functional Onco-Imaging, University of California, Irvine, CA 92697-5020, USA.
Muqing
M
Lin
Jeon-Hor
JH
Chen
Ke
K
Nie
Daniel
D
Chang
Orhan
O
Nalcioglu
Min-Ying
MY
Su
D000328:Adult; D000368:Aged; D000465:Algorithms; D001940:Breast / Q000098:blood supply*; D001943:Breast Neoplasms / Q000098:blood supply / Q000175:diagnosis*; D018270:Carcinoma, Ductal, Breast / Q000098:blood supply / Q000175:diagnosis*; D003287:Contrast Media; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008875:Middle Aged
D003287:Contrast Media