Can dialyzer membrane selection affect outcomes in patients with acute kidney injury requiring dialysis?
The choice of dialyzer membrane may potentially affect not only solute clearances but also blood-dialyzer interactions. Although on one hand alteration of the dialyzer surface or pore size to increase inflammatory mediator loss may potentially be beneficial for patients with acute kidney injury (AKI), dialyzer membrane interactions, which precipitate intradialytic hypotension, may worsen AKI. Several years ago cellulosic membrane dialyzers were shown to reduce both patient survival and renal recovery in patients with AKI. This review looks at the earlier studies of dialyzer membrane choice and outcomes in AKI, besides discussing the newer developments in membrane technology for patients with AKI.
UCL Center for Nephrology, Royal Free and University College Medical School, London, United Kingdom. andrew.davenport@royalfree.nhs.uk
Andrew
A
Davenport
D058186:Acute Kidney Injury / Q000628:therapy*; D006801:Humans; D008567:Membranes, Artificial; D006435:Renal Dialysis / Q000009:adverse effects / Q000295:instrumentation*
D008567:Membranes, Artificial