Cyclotides: macrocyclic peptides with applications in drug design and agriculture.
Cyclotides are disulfide-rich peptides from plants that are exceptionally stable as a result of their unique cyclic cystine knot structural motif. Their natural role is thought to be as plant defence agents, most notably against insect pests, but they also have potential applications in drug design and agriculture. This article identifies gaps in current knowledge on cyclotides and suggests future directions for research into this fascinating family of ultra-stable mini-proteins.
Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia. d.craik@imb.uq.edu.au
David J
DJ
Craik
Joshua S
JS
Mylne
Norelle L
NL
Daly
D000383:Agriculture; D000595:Amino Acid Sequence; D047169:Cyclotides / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D015195:Drug Design; D008969:Molecular Sequence Data; D032067:Oldenlandia / Q000378:metabolism; D010575:Pesticides / Q000737:chemistry / Q000378:metabolism; D017434:Protein Structure, Tertiary
D047169:Cyclotides; D010575:Pesticides; C091930:kalata B1