Animal models of anemia of inflammation.
Anemia of inflammation (AI) is a complex multi-organ response to inflammatory disorders. Because AI can result from many infectious and non-infectious inflammatory diseases, multiple mechanisms may contribute to its pathogenesis, including iron restriction, direct erythropoietic suppression, shortened red blood cell survival, and frank hemolysis. Animal models have been helpful in the study of the mechanisms of AI and its potential treatments, but each model reflects distinct aspects of this heterogeneous syndrome. It is therefore important to study a variety of models of AI. This review focuses on the use of infectious and noninfectious mouse models of inflammation that have been shown to manifest anemia. We review many of the models reported in the literature or developed in our laboratory, and discuss their respective merits and drawbacks.
Rivera
Seth
S
Department of Medicine, David Geffen School of Medicine at the University of California, Los Angeles, CA. sethrivera@mednet.ucla.edu
Ganz
Tomas
T
D000740:Anemia / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology; D000818:Animals; D023181:Antimicrobial Cationic Peptides / Q000378:metabolism; D001424:Bacterial Infections / Q000150:complications; D004195:Disease Models, Animal; D064451:Hepcidins; D007249:Inflammation / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology; D007501:Iron / Q000378:metabolism; D051379:Mice; D008822:Mice, Transgenic; D009164:Mycobacterium Infections / Q000150:complications; D010272:Parasitic Diseases / Q000150:complications; D015203:Reproducibility of Results
D023181:Antimicrobial Cationic Peptides; D064451:Hepcidins; D007501:Iron