Oral squamous papilloma: clinical, histologic and immunohistochemical analyses.
Oral squamous papilloma (OSP) is a benign proliferation of the stratified squamous epithelium, which results in a papillary or verrucous exophytic mass. Twelve patients suspected to have oral papilloma underwent excisional biopsy for histopathologic and immunohistochemical analysis. The majority of the patients (75%) were females, and the most prevalent site was the tongue, followed by the palate. The round and whitish form was present in 58.4% of the cases. The lesions were softened/flaccid in 66.7% of cases and a pedunculated attachment was seen in 75% of the lesions. The histopathologic examination revealed hyperparakeratosis, occasional basal hyperplasia, and koilocyte-like cells in 100% of the specimens. Immunohistochemical assays utilizing BP53-12 and Pab240 antibodies for p53 protein showed negative or weak immunostaining (91.6%) for both immunomarkers in all the epithelial layers examined. The findings suggest the benign nature of the lesions and small possibility of becoming malignant.
Laboratory of Pathology, Federal University of Jequitinhonha and Mucuri Vales (UFVJM), Diamantina, Brazil.
Thalassa E
TE
Carneiro
Sandra A
SA
Marinho
Flaviana D
FD
Verli
Ana T M
AT
Mesquita
Nádia L
NL
Lima
João L
JL
Miranda
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009062:Mouth Neoplasms / Q000378:metabolism / Q000473:pathology*; D010212:Papilloma / Q000378:metabolism / Q000473:pathology*; D016159:Tumor Suppressor Protein p53 / Q000032:analysis / Q000096:biosynthesis*; D014764:Viral Proteins / Q000032:analysis; D055815:Young Adult
D016159:Tumor Suppressor Protein p53; D014764:Viral Proteins