[Cytomorphological features of the neocortex in rats with genetic predisposition to absence epilepsy].
The aim of the study was to examine putative microstructural changes in the neocortex which accompany absence epilepsy. Rat strains WAG/Rij as a genetic model of absence epilepsy and ACI (control) were examined. Brain slices were stained after Nissl; neuronal and glial cells were identified and counted in the somatosensory, motor, and cingular cortices (in layers II/III, V, and VI, individually). In WAG/Rij rats, the density of neurons in the superficial layers (II/III) of the motor cortex appeared to be lower than in healthy control rats, whereas the density ofglial cells in WAG/Rij rats was higher. In the deep layers of the somatosensory and cingular areas, the density ofglial cells in WAG/Rijrats rats was lower as compared to control rats. The results demonstrate that absence epilepsy is associated with cytomorphological changes in the neocortex.
Kulikova
S N
SN
Sitnikova
E Iu
EIu
Raevskiĭ
V V
VV
D000818:Animals; D004832:Epilepsy, Absence / Q000235:genetics / Q000473:pathology*; D020022:Genetic Predisposition to Disease; D019579:Neocortex / Q000473:pathology*; D009457:Neuroglia / Q000502:physiology; D009474:Neurons / Q000473:pathology*; D051381:Rats