A new cytotoxic 19-nor-cardenolide from the latex of Antiaris toxicaria.
A new nor-cardenolide, named toxicarioside H (1), was isolated from the latex of Antiaris toxicaria (Pers.) Lesch (Moraceae). Its structure was elucidated on the basis of HRFAB-MS and spectroscopic techniques (IR, UV, 1D and 2D NMR). Compound 1 showed significant cytotoxicity against K562, SGC-7901, SMMC-7721, and HeLa cell lines in vitro by MTT method.
Key Laboratory of Tropical Crop Biotechnology, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China. hfdai@yahoo.cn
Hao-Fu
HF
Dai
Yu-Juan
YJ
Gan
Dong-Mei
DM
Que
Jiao
J
Wu
Zhen-Chang
ZC
Wen
Wen-Li
WL
Mei
D031621:Antiaris / Q000737:chemistry*; D002298:Cardenolides / Q000302:isolation & purification* / Q000494:pharmacology*; D002301:Cardiac Glycosides / Q000302:isolation & purification* / Q000494:pharmacology*; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D006801:Humans; D007840:Latex / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy
D002298:Cardenolides; D002301:Cardiac Glycosides; D007840:Latex; C545314:toxicarioside H