Effects of piperonyl butoxide on spontaneous behavior in F1-generation mice.
Piperonyl butoxide was given in the diet to provide levels of 0 (control), 0.02%, 0.06%, and 0.18% from 5 weeks of age of the F(0) generation to 12 weeks of age of the F(1) generation in mice. Select reproductive and neurobehavioral parameters were then measured. In exploratory behavior in the F(0) generation, vertical time of adult females increased significantly in a dose-related manner. In behavioral developmental parameters, cliff avoidance was delayed significantly in the high-dose group in male offspring, and this effect was significantly dose-related. In female offspring, surface righting was significantly delayed in the high-dose group, and this effect was significantly dose-related. In spontaneous behavior in the F(1) generation, females showed more activities in some variables in the high-dose group. Dose levels of piperonyl butoxide used in the present study produced several adverse effects in neurobehavioral parameters in mice.
Department of Environmental Health and Toxicology, Tokyo Metropolitan Institute of Public Health, Hyakunincho, Shinjuku-ku, Tokyo, Japan. t-tanaka@poohlover.net
Toyohito
T
Tanaka
Osamu
O
Takahashi
Shinshi
S
Oishi
Akio
A
Ogata
D000284:Administration, Oral; D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D016009:Chi-Square Distribution; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D051379:Mice; D010574:Pesticide Synergists / Q000008:administration & dosage / Q000633:toxicity*; D010882:Piperonyl Butoxide / Q000008:administration & dosage / Q000633:toxicity*
D010574:Pesticide Synergists; D010882:Piperonyl Butoxide