Asymmetric synthesis of the C7-C23 fragment of iriomoteolide-1a.
An efficient synthesis of the C(7)-C(23) fragment 2 of iriomoteolide-1a (1) has been accomplished via a B-alkyl Suzuki-Miyaura cross-coupling reaction followed by deprotection and cyclization to form the cyclic hemiketal core.
Xie
Jun
J
Department of Molecular Medicine, Beckman Research Institute at City of Hope, Duarte, California 91010, USA.
Ma
Yuelong
Y
Horne
David A
DA
D002384:Catalysis; D003500:Cyclization; D004141:Dinoflagellida / Q000737:chemistry; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
D018942:Macrolides; C520799:iriomoteolide-1a