Anti-influenza-virus activity of total alkaloids from Commelina communis L.
The antiviral activity of total alkaloids from Commelina communis L. (TAC) against influenza virus A/PR/8/34 (H1N1) was investigated in vitro and in vivo. TAC exhibited an inhibitory action on the growth of influenza virus in Madin-Darby canine kidney cells when added before or after viral infection. In mice infected with influenza virus, orally administered TAC at 8, 16 or 32 mg/kg per day for 6 days significantly increased the survival rate, prolonged the mean survival time and reduced the viral titers in the lung and the lung index, compared with that of the untreated virus control. The results obtained suggest that TAC has a pronounced protective effect against infection by influenza A virus.
Key Laboratory of TCM Resource and Compound Prescription, Ministry of Education, Hubei College of Traditional Chinese Medicine, Wuhan, China. bingfeihong@126.com
Fei-Hong
FH
Bing
Jun
J
Liu
Zhi
Z
Li
Guo-Bin
GB
Zhang
Yi-Fan
YF
Liao
Jing
J
Li
Chang-Yuan
CY
Dong
D000470:Alkaloids / Q000737:chemistry* / Q000494:pharmacology*; D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D034822:Commelina / Q000737:chemistry*; D004285:Dogs; D005260:Female; D053118:Influenza A Virus, H1N1 Subtype / Q000187:drug effects*; D051379:Mice; D008807:Mice, Inbred BALB C; D009976:Orthomyxoviridae Infections / Q000188:drug therapy*; D013047:Specific Pathogen-Free Organisms
D000470:Alkaloids; D000998:Antiviral Agents