Pd(II)-catalyzed hydroxylation of arenes with 1 atm of O(2) or air.
Pd(II)-catalyzed ortho-hydroxylation of variously substituted benzoic acids under 1 atm of O(2) or air is achieved under nonacidic conditions. Extensive labeling studies support a direct oxygenation of aryl C-H bonds with molecular oxygen.
Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
Yang-Hui
YH
Zhang
Jin-Quan
JQ
Yu
D000388:Air; D001565:Benzoates / Q000737:chemistry; D002384:Catalysis; D006841:Hydrocarbons, Aromatic / Q000737:chemistry*; D006900:Hydroxylation; D007700:Kinetics; D010100:Oxygen / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D013379:Substrate Specificity
D001565:Benzoates; D006841:Hydrocarbons, Aromatic; D010165:Palladium; D010100:Oxygen