Reactive calcium-phosphate-containing poly(ester-co-ether) methacrylate bone adhesives: chemical, mechanical and biological considerations.
A poly(propylene glycol-co-lactide) dimethacrylate adhesive with monocalcium phosphate monohydrate (MCPM)/beta-tricalcium phosphate (beta-TCP) fillers in various levels has been investigated. Water sorption by the photo-polymerized materials catalyzed varying filler conversion to dicalcium phosphate (DCP). Polymer modulus was found to be enhanced upon raising total calcium phosphate content. With greater DCP levels, faster release of phosphate and calcium ions and improved buffering of polymer degradation products were observed. This could reduce the likelihood of pH-catalyzed bulk degradation and localized acid production and thereby may prevent adverse biological responses. Bone-like MG-63 cells were found to attach, spread and have normal morphology on both the polymer and composite surfaces. Moreover, composites implanted into chick embryo femurs became closely apposed to the host tissue and did not appear to induce adverse immunological reaction. The above results suggest that the new composite materials hold promise as clinical effective bone adhesives.
Division of Biomaterials and Tissue Engineering, UCL Eastman Dental Institute, 256 Gray's Inn Road, London WC1X 8LD, UK.
Xin
X
Zhao
Irwin
I
Olsen
Haoying
H
Li
Kris
K
Gellynck
Paul G
PG
Buxton
Jonathan C
JC
Knowles
Vehid
V
Salih
Anne M
AM
Young
D000818:Animals; D001843:Bone Cements / Q000737:chemistry* / Q000627:therapeutic use*; D002130:Calcium Phosphates / Q000737:chemistry* / Q000627:therapeutic use*; D002448:Cell Adhesion; D002460:Cell Line; D002642:Chick Embryo; D019245:Compressive Strength; D005264:Femoral Fractures / Q000473:pathology / Q000628:therapy*; D006244:Hardness; D006801:Humans; D008422:Materials Testing; D008689:Methacrylates / Q000737:chemistry* / Q000627:therapeutic use*; D010006:Osteoblasts / Q000166:cytology / Q000502:physiology*; D010012:Osteogenesis; D016896:Treatment Outcome
D001843:Bone Cements; D002130:Calcium Phosphates; D008689:Methacrylates