Anticitrullinated protein/peptide antibodies and rheumatoid factors: two distinct autoantibody systems.
In a previous issue of Arthritis Research and Therapy, Ursum and colleagues report the relative stabilities of anticitrullinated protein/peptide antibodies (ACPAs) and IgM rheumatoid factors during the course of rheumatoid arthritis and their differential correlation with markers of the acute-phase response. These findings add to a growing body of evidence highlighting the distinct nature of these two autoantibody systems and the role of ACPAs as a disease-specific marker of rheumatoid arthritis.
Guido
G
Valesini
Cristiano
C
Alessandri
D000210:Acute-Phase Reaction / Q000097:blood / Q000276:immunology; D001172:Arthritis, Rheumatoid / Q000097:blood* / Q000276:immunology; D001323:Autoantibodies / Q000097:blood* / Q000276:immunology; D001324:Autoantigens / Q000276:immunology; D015415:Biomarkers / Q000097:blood*; D002956:Citrulline / Q000097:blood / Q000276:immunology*; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood / Q000276:immunology; D012217:Rheumatoid Factor / Q000097:blood* / Q000276:immunology
D001323:Autoantibodies; D001324:Autoantigens; D015415:Biomarkers; D007075:Immunoglobulin M; D002956:Citrulline; D012217:Rheumatoid Factor