Dm nxf1/sbr gene affects the formation of meiotic spindle in female Drosophila melanogaster.
The small bristles (sbr) gene of Drosophila melanogaster belongs to the family of nuclear export factor (NXF) genes that participate in mRNA nuclear export. During meiosis, females of Drosophila melanogaster that carry various combinations of mutant alleles of the Dm nxf1/sbr gene exhibit disruption of the division spindle and misalignment of chromosomes at the metaphase plate. Meiosis of sbr ( 5 ) /+ females is characterized by the formation of tripolar spindles during the first cell division. According to the sequencing results, the sbr ( 5 ) (l(1)K4) lethal allele is a deletion of 492 nucleotides. In SBR(5) protein, 57 of the 146 amino acids that have been lost by deletion belong to the NTF2-like domain.
Golubkova
Elena V
EV
Department of Genetics, St. Petersburg State University, Universitetskaya nab., 7/9, 199034, Saint-Petersburg, Russia. gelena@EG10217.spb.edu
Markova
Ekaterina G
EG
Markov
Anton V
AV
Avanesyan
Elina O
EO
Nokkala
Seppo
S
Mamon
Ludmila A
LA
D000483:Alleles; D000818:Animals; D001483:Base Sequence; D029721:Drosophila Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D004331:Drosophila melanogaster / Q000737:chemistry / Q000166:cytology* / Q000235:genetics* / Q000378:metabolism; D005260:Female; D017353:Gene Deletion; D008297:Male; D008540:Meiosis; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009154:Mutation; D009687:Nuclear Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D016601:RNA-Binding Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D016415:Sequence Alignment; D008941:Spindle Apparatus / Q000235:genetics*
D029721:Drosophila Proteins; D009687:Nuclear Proteins; D016601:RNA-Binding Proteins; C445086:SBR protein, Drosophila