The impact of ischemic cholangiopathy in liver transplantation using donors after cardiac death: the untold story.
BACKGROUND
Liver transplantation (LT) from donation after cardiac death (DCD) donors is increasingly being used to address organ shortages. Despite encouraging reports, standard survival metrics have overestimated the effectiveness of DCD livers. We examined the mode, kinetics, and predictors of organ failure and resource utilization to more fully characterize outcomes after DCD LT.


METHODS
We reviewed the outcomes for 32 DCD and 237 donation after brain death (DBD) LT recipients at our institution.


RESULTS
Recipients of DCD livers had a 2.1 times greater risk of graft failure, a 2.5 times greater risk of relisting, and a 3.2 times greater risk of retransplantation compared with DBD recipients. DCD recipients had a 31.6% higher incidence of biliary complications and a 35.8% higher incidence of ischemic cholangiopathy. Ischemic cholangiography was primarily implicated in the higher risk of graft failure observed after DCD LT. DCD recipients with ischemic cholangiography experienced more frequent rehospitalizations, longer hospital stays, and required more invasive biliary procedures.


CONCLUSIONS
Related to higher complication rates, DCD recipients necessitated greater resource utilization. This more granular data should be considered in the decision to promote DCD LT. Modification of liver allocation policy is necessary to address those disadvantaged by a failing DCD graft.
Skaro
Anton I
AI
Division of Organ Transplantation, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. askaro@nmh.org
Jay
Colleen L
CL
Baker
Talia B
TB
Wang
Edward
E
Pasricha
Sarina
S
Lyuksemburg
Vadim
V
Martin
John A
JA
Feinglass
Joseph M
JM
Preczewski
Luke B
LB
Abecassis
Michael M
MM
D000328:Adult; D000368:Aged; D001649:Bile Duct Diseases / Q000209:etiology*; D002760:Cholangiopancreatography, Endoscopic Retrograde; D003643:Death; D005260:Female; D006085:Graft Survival; D006295:Health Resources / Q000706:statistics & numerical data; D006801:Humans; D007511:Ischemia / Q000209:etiology*; D016031:Liver Transplantation / Q000009:adverse effects* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D014019:Tissue Donors; D009927:Tissue and Organ Procurement; D016896:Treatment Outcome