Resting our cortices by going DOWN to sleep.
In this issue of Neuron, Vyazovskiy et al. reports on progressive changes in cortical unit activity within extended wakefulness and within extended sleep paralleling changes in EEG slow-wave sleep activity. Sleep debt may be integrated at the level of individual cortical neurons, providing support for the synaptic homeostasis theory.
Mignot
Emmanuel
E
Stanford University Center for Narcolepsy, Palo Alto, CA 94304-5742, USA. mignot@stanford.edu
Huguenard
John R
JR
D000200:Action Potentials / Q000502:physiology; D000818:Animals; D002540:Cerebral Cortex / Q000166:cytology* / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D009474:Neurons / Q000502:physiology*; D051381:Rats; D012146:Rest / Q000502:physiology*; D012890:Sleep / Q000502:physiology*