Immune reconstitution inflammatory syndrome associated with Aspergillus terreus pulmonary infection in an autologous stem cell transplant recipient.
We describe an autologous stem cell transplant recipient who developed immune reconstitution inflammatory syndrome (IRIS) associated with Aspergillus terreus invasive pulmonary infection after recovery from neutropenia. Clinical and radiological worsening of pulmonary invasive aspergillosis coincident with a robust decline of serum galactomannan values and rising neutrophil counts should be interpreted as IRIS and should not require changes to antifungal therapy.
Department of Clinical Sciences, Section of Infectious Diseases and Immunopathology, Università degli Studi di Milano, Milan, Italy. spinello.antinori@unimi.it
S
S
Antinori
M
M
Corbellino
A
A
Necchi
P
P
Corradini
C
C
Vismara
V
V
Montefusco
A M
AM
Gianni
D001230:Aspergillus / Q000145:classification; D006801:Humans; D054019:Immune Reconstitution Inflammatory Syndrome / Q000150:complications*; D055744:Invasive Pulmonary Aspergillosis / Q000150:complications* / Q000382:microbiology; D008172:Lung Diseases, Fungal / Q000150:complications* / Q000382:microbiology*; D008297:Male; D008875:Middle Aged; D033581:Stem Cell Transplantation / Q000009:adverse effects*; D014182:Transplantation, Autologous / Q000009:adverse effects*