Gene polymorphism of IFNG +874 T/A and TLR4 +896 A/G and recurrent infections and wheezing in toddlers with history of bronchiolitis.
Cytokine and TLR4 polymorphisms and their association with the infection history of 129 children hospitalized for bronchiolitis during the first 6 months of life were analyzed. The carriers of IFNG +874 T/A allele A had fewer infections and use of inhaled corticosteroids and the carriers of TLR4+896 A/G allele G were more likely to need tympanostomy than noncarriers.
Nuolivirta
Kirsi
K
Paediatric Research Centre, University of Tampere and Seinäjoki Central Hospital, Tampere, Finland.
Hurme
Mikko
M
Halkosalo
Anne
A
Koponen
Petri
P
Korppi
Matti
M
Vesikari
Timo
T
Helminen
Merja
M
D001988:Bronchiolitis / Q000235:genetics*; D002675:Child, Preschool; D005260:Female; D020022:Genetic Predisposition to Disease; D006579:Heterozygote; D006801:Humans; D007223:Infant; D007371:Interferon-gamma / Q000235:genetics*; D016753:Interleukin-10 / Q000235:genetics*; D020382:Interleukin-18 / Q000235:genetics; D008297:Male; D012135:Respiratory Sounds / Q000235:genetics*; D051197:Toll-Like Receptor 4 / Q000235:genetics*
C508609:IL10 protein, human; D020382:Interleukin-18; C495345:TLR4 protein, human; D051197:Toll-Like Receptor 4; D016753:Interleukin-10; D007371:Interferon-gamma