Durable hypogammaglobulinemia associated with thymoma (Good syndrome).
Good syndrome, characterized by hypogammaglobulinemia and acquired immunodeficiency, is a rare condition associated with thymoma. A 67-year-old woman, who 4 months previously had a thymoma resected, presented with generalized hypogammaglobulinemia with a severely decreased B cell population as demonstrated by flow cytometry. She was diagnosed as having bacterial mediastinitis associated with Good syndrome. For the subsequent 6 years, she suffered from repeated serious bacterial infections. As this paraneoplastic syndrome is not resolved by tumor removal, careful management with intensive infection-control using antibiotics and intravenous immunoglobulins is required for the long term. Serum immunoglobulin levels should be evaluated for patients with thymoma and suspected vulnerability to infection.
Kitamura
Atsushi
A
Department of Respirology, Graduate School of Medicine, Chiba University, Chiba.
Takiguchi
Yuichi
Y
Tochigi
Naobumi
N
Watanabe
Shun-ichi
S
Sakao
Seiichirou
S
Kurosu
Katsushi
K
Tanabe
Nobuhiro
N
Tatsumi
Koichiro
K
D000361:Agammaglobulinemia / Q000150:complications* / Q000276:immunology; D000368:Aged; D001402:B-Lymphocytes / Q000276:immunology; D005260:Female; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000150:complications / Q000276:immunology; D008231:Lymphopenia / Q000150:complications / Q000276:immunology; D010257:Paraneoplastic Syndromes / Q000150:complications / Q000276:immunology; D013577:Syndrome; D013945:Thymoma / Q000150:complications* / Q000175:diagnosis / Q000276:immunology; D013953:Thymus Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000276:immunology; D013997:Time Factors