Asymmetric meso-aziridine ring-opening reactions using a chiral zirconium catalyst.
A chiral zirconium catalyst prepared from Zr(O(t)Bu)4 and a chiral tridentate BINOL was found to be effective for asymmetric meso-aziridine ring-opening reactions with aniline derivatives. The N-benzhydryl group on the product obtained was easily cleaved to give the corresponding amine in high yield under reductive conditions.
Department of Chemistry, School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Kazutaka
K
Seki
Rongmin
R
Yu
Yumi
Y
Yamazaki
Yasuhiro
Y
Yamashita
Shū
S
Kobayashi
D000814:Aniline Compounds / Q000737:chemistry; D001388:Aziridines / Q000737:chemistry*; D002384:Catalysis; D013237:Stereoisomerism; D015040:Zirconium / Q000737:chemistry*
D000814:Aniline Compounds; D001388:Aziridines; C033132:aziridine; D015040:Zirconium; C023650:aniline