title: [Preliminary observation of the blocking effect produced by injecting polyacrylamide hydrogel on low hydraulic resistance channel along meridian].
abstract: To study the role of meridians in the formation and development of diseases, a pathological model of obstructed channel was established by injecting polyacrylamide hydrogel. The effects of blocking low hydraulic resistance channel (LHRC), produced by injecting polyacrylamide hydrogel and by injecting normal saline, were compared by examining the change in transmission of interstitial fluid pressure wave. The results showed that there was significant decrease (P < 0.01) in interstitial fluid pressure wave after more than 0.5 ml polyacrylamide hydrogel was injected into the channel, whereas no significant changes were found after normal saline was injected or when the hydrogel was outside the channel. The above findings demonstrate that the low hydraulic resistance channel can be blocked by injecting certain amount of polyacrylamide hydrogel and a pathological model of obstructed channel has been established preliminarily.
authors.affiliation: Institute of Acupuncture & Moxibustion, China Academy of Chinese Medical Science, Beijing 100700, China.
authors.forename: Yihui
authors.initials: Y
authors.lastname: Xu
authors.forename: Weibo
authors.initials: W
authors.lastname: Zhang
authors.forename: Yuying
authors.initials: Y
authors.lastname: Tian
authors.forename: Ruihong
authors.initials: R
authors.lastname: Wang
authors.forename: Lingling
authors.initials: L
authors.lastname: Wang
authors.forename: Tao
authors.initials: T
authors.lastname: Huang
authors.forename: Guangjun
authors.initials: G
authors.lastname: Wang
mesh_terms: D000180:Acrylic Resins / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D008297:Male; D008516:Medicine, Chinese Traditional / Q000379:methods*; D016740:Meridians; D011897:Random Allocation; D013552:Swine; D013556:Swine, Miniature
chemical_list: D000180:Acrylic Resins; C016680:polyacrylamide gels