title: Serum selenium and prognosis in cardiovascular disease: results from the AtheroGene study.
abstract: OBJECTIVE
  Experimental data suggest a protective role of the essential trace element selenium against cardiovascular disease (CVD), whereas epidemiological data remains controversial. We aimed to investigate the impact of serum selenium concentration in patients presenting with stable angina pectoris (SAP) or acute coronary syndrome (ACS) on long term prognosis.
  
  
  METHODS
  Baseline selenium concentration was measured in 1731 individuals (852 with SAP, and 879 with ACS). During a median follow-up of 6.1 years, 190 individuals died from cardiovascular causes.
  
  
  RESULTS
  In those ACS patients who subsequently died of cardiac causes, selenium levels were lower compared to survivors (61.0microg/L versus 71.5microg/L; P<0.0001). In a fully adjusted model, patients in the highest tertile of selenium concentration had a hazard ratio of 0.38 (95% CI: 0.16-0.91; P=0.03) as compared with those in the lowest. No association between selenium levels and cardiovascular outcome was observed in SAP.
  
  
  CONCLUSIONS
  Low selenium concentration was associated with future cardiovascular death in patients with ACS.
authors.affiliation: Department of Medicine II, Johannes Gutenberg-University Mainz, Langenbeckstr. 1, Mainz, Germany.
authors.forename: Edith
authors.initials: E
authors.lastname: Lubos
authors.forename: Christoph R
authors.initials: CR
authors.lastname: Sinning
authors.forename: Renate B
authors.initials: RB
authors.lastname: Schnabel
authors.forename: Philipp S
authors.initials: PS
authors.lastname: Wild
authors.forename: Tanja
authors.initials: T
authors.lastname: Zeller
authors.forename: Hans J
authors.initials: HJ
authors.lastname: Rupprecht
authors.forename: Christoph
authors.initials: C
authors.lastname: Bickel
authors.forename: Karl J
authors.initials: KJ
authors.lastname: Lackner
authors.forename: Dirk
authors.initials: D
authors.lastname: Peetz
authors.forename: Joseph
authors.initials: J
authors.lastname: Loscalzo
authors.forename: Thomas
authors.initials: T
authors.lastname: Münzel
authors.forename: Stefan
authors.initials: S
authors.lastname: Blankenberg
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood / Q000401:mortality*; D000368:Aged; D000787:Angina Pectoris / Q000097:blood / Q000401:mortality*; D050197:Atherosclerosis / Q000097:blood / Q000401:mortality*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D012643:Selenium / Q000097:blood*; D015996:Survival Rate
chemical_list: D012643:Selenium