Secondary metabolomics: natural products mass spectrometry goes global.
A global LC-MS metabolite analysis of wild-type Pseudomonas auerigunosa and mutants targeting the natural product pyochelin revealed the production of previously unknown metabolites, the 2-alkyl-4,5-dihydrothiazole-4-carboxylates.
Kersten
Roland D
RD
Skaggs School of Pharmacy and Pharmaceutical Sciences, Department of Pharmacology, Center for Marine Biotechnology and Biomedicine, University of California,San Diego 92093, USA.
Dorrestein
Pieter C
PC
D000818:Animals; D001688:Biological Products / Q000032:analysis* / Q000737:chemistry / Q000378:metabolism; D013058:Mass Spectrometry / Q000379:methods*; D055432:Metabolomics / Q000379:methods*; D010636:Phenols / Q000737:chemistry / Q000378:metabolism; D011550:Pseudomonas aeruginosa / Q000737:chemistry / Q000378:metabolism*; D013844:Thiazoles / Q000737:chemistry / Q000378:metabolism
D001688:Biological Products; D010636:Phenols; D013844:Thiazoles; C025316:pyochelin