title: High-intensity laser and photodynamic therapy as a treatment for recurrent herpes labialis.
abstract: OBJECTIVE
  The aim of this study was to report the treatment of recurrent herpes labialis (RHL) using a high-intensity laser or methylene blue (MB)-mediated photodynamic therapy (PDT) in combination with low-level laser therapy (LLLT).
  
  
  METHODS
  Four clinical cases of patients diagnosed with RHL are described in this report. Two patients were subjected to high-intensity laser therapy (HILT) followed by LLLT, and two patients received MB-mediated PDT, again followed by LLLT. LLLT was conducted at 24, 48, 72 h, and 7 d after HILT or PDT. Patients were followed up after 6 mo.
  
  
  RESULTS
  Throughout the follow-up period, all patients reported pain relief and did not show any signs or symptoms of RHL. A favorable healing process was observed in all cases. None of the patients reported pain as a consequence of the treatment.
  
  
  CONCLUSIONS
  These results suggest that HILT and MB-mediated PDT, in combination with LLLT, may constitute a benefit when treating vesicles in RHL.
authors.affiliation: Department of Prosthodontics/Special Laboratory of Lasers in Dentistry (LELO), School of Dentistry, University of São Paulo, São Paulo, Brazil. marotti@usp.br
authors.forename: Juliana
authors.initials: J
authors.lastname: Marotti
authors.forename: Felipe Fornias
authors.initials: FF
authors.lastname: Sperandio
authors.forename: Eduardo Rodrigues
authors.initials: ER
authors.lastname: Fregnani
authors.forename: Ana Cecilia Corrêa
authors.initials: AC
authors.lastname: Aranha
authors.forename: Patrícia Moreira
authors.initials: PM
authors.lastname: de Freitas
authors.forename: Carlos de Paula
authors.initials: Cde P
authors.lastname: Eduardo
mesh_terms: D000293:Adolescent; D003131:Combined Modality Therapy; D005260:Female; D006560:Herpes Labialis / Q000532:radiotherapy*; D006801:Humans; D053685:Laser Therapy; D028022:Low-Level Light Therapy; D008297:Male; D010778:Photochemotherapy; D012008:Recurrence; D014945:Wound Healing / Q000528:radiation effects; D055815:Young Adult