title: Discriminated benefits of a Mediterranean dietary pattern within a hypocaloric diet program on plasma RBP4 concentrations and other inflammatory markers in obese subjects.
abstract: Personalized nutritional strategies to treat obesity may specifically influence inflammatory markers, in addition to reduce body weight. In the present study, we evaluated the effect of a hypocaloric diet based on a Mediterranean dietary pattern (MDP) on nutritional status as well as on plasma concentrations of retinol binding protein-4 (RBP4) and other proinflammatory markers. Fourty-one subjects (24F/17M; age: 37 ± 7 years; BMI: 32.2 ± 3.9 kg/m²) were assigned to follow a MDP within a caloric-restricted diet over an 8-week period. Anthropometrical, clinical, and biochemical variables were measured at baseline and endpoint after the nutritional program. Dietary intervention resulted in a mean weight loss of -4.4 ± 2.5 kg (P < 0.001) and marked reductions (P < 0.05) in plasma concentrations of RBP4, leptin, C-reactive protein, complement C3, and tumor necrosis factor-alpha (TNFα). Individuals with a higher adherence to the MDP during the nutritional intervention presented differentially higher reductions (P < 0.05) in plasma RBP4, IL6, and TNFα. In addition, the increase in the Mediterranean diet score from baseline was a significant and independent predictor factor for the decrease in plasma RBP4 concentration (P < 0.05). In conclusion, our findings suggest that following a hypocaloric diet accompanying a high adherence to a MDP resulted in specific reductions on proinflammatory markers, in addition to a significant improvement in some metabolic syndrome features induced by weight loss, which could be a good combined strategy to treat obesity as well as related metabolic and inflammatory disorders.
authors.affiliation: Department of Nutrition and Food Sciences, Physiology and Toxicology, Institute of Nutrition and Food Sciences, University of Navarra, C/Irunlarrea, 1, Pamplona 31008, Spain.
authors.forename: Helen Hermana Miranda
authors.initials: HH
authors.lastname: Hermsdorff
authors.forename: M Ángeles
authors.initials: MÁ
authors.lastname: Zulet
authors.forename: Itziar
authors.initials: I
authors.lastname: Abete
authors.forename: J Alfredo
authors.initials: JA
authors.lastname: Martínez
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure / Q000502:physiology; D001823:Body Composition; D015992:Body Mass Index; D031204:Caloric Restriction; D038441:Diet, Mediterranean; D004038:Diet, Reducing; D005260:Female; D006801:Humans; D007249:Inflammation / Q000178:diet therapy; D018836:Inflammation Mediators / Q000097:blood*; D008297:Male; D009765:Obesity / Q000097:blood / Q000178:diet therapy* / Q000503:physiopathology; D009994:Osmolar Concentration; D054839:Retinol-Binding Proteins, Plasma / Q000032:analysis*; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D018836:Inflammation Mediators; C101326:RBP4 protein, human; D054839:Retinol-Binding Proteins, Plasma