In vitro antifungal activity of phenylheptatriyne from Bidens cernua L. against yeasts.
In vitro antifungal activity of phenylheptatriyne from Bidens cernua L. (Asteraceae) was studied using broth macrodilution method against 125 strains of yeasts including 104 clinical and other isolates of Candida spp. (C. albicans, C. krusei, C. tropicalis, C. guilliermondii, C. parapsilosis, C. glabrata, C. inconspicua), 16 strains of basidiomycetous yeasts (Cryptococcus neoformans, C. albidus, Trichosporon cutaneum, Rhodotorula glutinis) and five standard reference strains of Candida species. Phenylheptatriyne has shown significant activity against investigated strains, and the Minimal Inhibitory Concentrations for Candida spp. were determined as 12.5-50 microg/ml and for basidiomycetous yeasts as 12.5-100 microg/ml.
Rybalchenko
N P
NP
Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, Kyiv, Ukraine. nrybalchenko@ukr.net
Prykhodko
V A
VA
Nagorna
S S
SS
Volynets
N N
NN
Ostapchuk
A N
AN
Klochko
V V
VV
Rybalchenko
T V
TV
Avdeeva
L V
LV
D000480:Alkynes / Q000302:isolation & purification / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D001487:Basidiomycota / Q000187:drug effects; D031176:Bidens / Q000737:chemistry*; D002175:Candida / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D015003:Yeasts / Q000187:drug effects*
D000480:Alkynes; D000935:Antifungal Agents; D010936:Plant Extracts; C019518:phenylheptatriyne