title: An efficient method for the preparation of peptide alcohols.
abstract: N-protected LL-dipeptide alcohols 3a-p, diastereomeric mixture (3d + 3d') and tripeptide alcohols 6a-c were synthesized by treatment of various amino alcohols with N-protected(alpha-aminoacyl)benzotriazoles 1a-c, 1f-m, (1a + 1a') and N-protected(alpha-dipeptidoyl)benzotriazoles 5a, 5b respectively in good yields with complete retention of chirality.
authors.affiliation: Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA. katritzky@chem.ufl.edu
authors.forename: Alan Roy
authors.initials: AR
authors.lastname: Katritzky
authors.forename: Nader Elmaghwry
authors.initials: NE
authors.lastname: Abo-Dya
authors.forename: Srinivasa Rao
authors.initials: SR
authors.lastname: Tala
authors.forename: Kapil
authors.initials: K
authors.lastname: Gyanda
authors.forename: Zakaria Kamel
authors.initials: ZK
authors.lastname: Abdel-Samii
mesh_terms: D000438:Alcohols / Q000138:chemical synthesis / Q000737:chemistry*; D000605:Amino Alcohols / Q000737:chemistry; D009842:Oligopeptides / Q000737:chemistry*; D012996:Solutions; D013237:Stereoisomerism; D014230:Triazoles / Q000737:chemistry
chemical_list: D000438:Alcohols; D000605:Amino Alcohols; D009842:Oligopeptides; D012996:Solutions; D014230:Triazoles; C012771:benzotriazole