title: Enantioselective copper-catalyzed reductive Michael cyclizations.
abstract: In the presence of siloxanes as stoichiometric reductants, chiral copper-bisphosphine complexes catalyze highly enantioselective reductive Michael cyclizations of substrates containing two alpha,beta-unsaturated carbonyl moieties. The diastereochemical outcome of these reactions is dependent upon whether biaryl- or ferrocene-based chiral bisphosphines are employed.
authors.affiliation: School of Chemistry, University of Edinburgh, The King's Buildings, West Mains Road, Edinburgh, EH9 3JJ, United Kingdom.
authors.forename: Claire L
authors.initials: CL
authors.lastname: Oswald
authors.forename: Justine A
authors.initials: JA
authors.lastname: Peterson
authors.forename: Hon Wai
authors.initials: HW
authors.lastname: Lam