One-pot synthesis of pH- and thermo-sensitive chitosan-based nanoparticles by the polymerization of acrylic acid/chitosan with macro-RAFT agent.
Thermo- and pH-sensitive chitosan-based nanoparticles were successfully prepared by one-pot polymerization of acrylic acid/chitosan with poly(N-isopropylacrylamide) (PNIPAM) macro-RAFT agent. The spherical and monodisperse nanoparticles were obtained with the diameters of about 100 nm at 25 degrees C (pH=6.5), and PNIPAM was anchored as the shell via the RAFT process. The disorder shell and the large aggregates were observed at 40 degrees C (pH=6.5); and the spherical nanoparticles broke up at 25 degrees C when pH was lowered to 3. This work may provide a facile "one-pot" method to prepare functionalized chitosan-based nanoparticles without N-phthaloylation of chitosan in the process.
Jiang
Jing
J
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, PR China.
Hua
Daoben
D
Tang
Jing
J
D000178:Acrylamides / Q000737:chemistry*; D000179:Acrylates / Q000737:chemistry*; D000180:Acrylic Resins; D002625:Chemistry, Organic / Q000379:methods*; D048271:Chitosan / Q000138:chemical synthesis* / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D011108:Polymers / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature
D000178:Acrylamides; D000179:Acrylates; D000180:Acrylic Resins; D011108:Polymers; C052970:poly-N-isopropylacrylamide; D048271:Chitosan; C036658:acrylic acid