DNA distress: just ring 9-1-1.
The Rad9-Hus1-Rad1 checkpoint clamp (9-1-1) is a central player in the cellular response to DNA damage; three groups have determined the crystal structure of 9-1-1, providing new insight into its loading mechanism and association with DNA damage checkpoint and repair enzymes.
Kemp
Michael
M
Department of Biochemistry and Biophysics and Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
Sancar
Aziz
A
D018797:Cell Cycle Proteins / Q000737:chemistry / Q000502:physiology*; D004249:DNA Damage; D004260:DNA Repair; D005092:Exonucleases / Q000737:chemistry / Q000502:physiology*; D008958:Models, Molecular; D017434:Protein Structure, Tertiary
D018797:Cell Cycle Proteins; C549605:HUS1 protein, human; C462949:HUS1B protein, human; C069930:rad9 protein; D005092:Exonucleases; C113574:Rad1 protein, human