title: Dietary fat intake and risk of Parkinson's disease: a case-control study in Japan.
abstract: The present case-control study examined the relationship between dietary intake of individual fatty acids and the risk of Parkinson's disease (PD) in Japan. Included were 249 cases within 6 years of onset of PD. Controls were 368 inpatients and outpatients without a neurodegenerative disease. Information on dietary factors was collected using a validated self-administered diet history questionnaire. Compared with arachidonic acid intake in the first quartile, consumption of that in the fourth quartile was significantly related to an increased risk of PD: the adjusted odds ratio between extreme quartiles was 2.09 (95% confidence interval: 1.21-3.64, P for trend=0.008). Cholesterol intake was also significantly positively associated with the risk of PD: the adjusted odds ratio between extreme quartiles was 1.78 (95% confidence interval: 1.04-3.05, P for trend=0.01). Consumption of total fat, saturated fatty acids, monounsaturated fatty acids, n-3 polyunsaturated fatty acids, alpha-linolenic acid, eicosapentaenoic acid, docosahexaenoic acid, n-6 polyunsaturated fatty acids, and linoleic acid and the ratio of n-3 to n-6 polyunsaturated fatty acid intake were not associated with PD. Higher consumption of arachidonic acid and cholesterol may be related to an increased risk of PD.
authors.affiliation: Department of Public Health, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan. miyake-y@fukuoka-u.ac.jp
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Miyake
authors.forename: Satoshi
authors.initials: S
authors.lastname: Sasaki
authors.forename: Keiko
authors.initials: K
authors.lastname: Tanaka
authors.forename: Wakaba
authors.initials: W
authors.lastname: Fukushima
authors.forename: Chikako
authors.initials: C
authors.lastname: Kiyohara
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Tsuboi
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Yamada
authors.forename: Tomoko
authors.initials: T
authors.lastname: Oeda
authors.forename: Takami
authors.initials: T
authors.lastname: Miki
authors.forename: Nobutoshi
authors.initials: N
authors.lastname: Kawamura
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Sakae
authors.forename: Hidenao
authors.initials: H
authors.lastname: Fukuyama
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Hirota
authors.forename: Masaki
authors.initials: M
authors.lastname: Nagai
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D002791:Cholesterol, Dietary; D004034:Diet Surveys; D004041:Dietary Fats; D005227:Fatty Acids; D015525:Fatty Acids, Omega-3; D005247:Feeding Behavior / Q000502:physiology*; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010300:Parkinson Disease / Q000453:epidemiology*; D012959:Socioeconomic Factors; D011795:Surveys and Questionnaires
chemical_list: D002791:Cholesterol, Dietary; D004041:Dietary Fats; D005227:Fatty Acids; D015525:Fatty Acids, Omega-3