Inhibitive effects of alkyl gallates on hyaluronidase and collagenase.
A series of the gallate esters of n-alkanols (C(1)-C(12)) was examined to determine their inhibitory activities against hyaluronidase and collagenase. Hexyl, heptyl, octyl, nonyl, and decyl gallates inhibited both hyaluronidase and collagenase, and the most potent inhibitor was octyl gallate against both enzymes. Octyl 3,5-dihydroxybenzoate showed inhibitory effects on hyaluronidase, whereas collagenase was inhibited by octyl 3,4-dihydroxybenzoate.
Barla
Florin
F
Department of Applied Biological Chemistry, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Sakai, Osaka, Japan.
Higashijima
Hayato
H
Funai
Shingo
S
Sugimoto
Keiichiro
K
Harada
Naoki
N
Yamaji
Ryoichi
R
Fujita
Tomoyuki
T
Nakano
Yoshihisa
Y
Inui
Hiroshi
H
D000818:Animals; D002417:Cattle; D047009:Hathewaya histolytica / Q000201:enzymology; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D005707:Gallic Acid / Q000737:chemistry* / Q000494:pharmacology*; D006821:Hyaluronoglucosaminidase / Q000037:antagonists & inhibitors*; D020128:Inhibitory Concentration 50; D061965:Matrix Metalloproteinase Inhibitors
D004791:Enzyme Inhibitors; D061965:Matrix Metalloproteinase Inhibitors; D005707:Gallic Acid; D006821:Hyaluronoglucosaminidase