title: Prior authorization for topical psoriasis treatments: is it cost-beneficial for managed care?
abstract: OBJECTIVE
  The introduction of novel therapeutic options for psoriasis has raised managed care's interest in controlling costs associated with dermatological treatments. Prior authorization (PA) can be a successful way of managing costs. However, experience with topical treatments for acne suggests that PA may not be cost-effective. The role of managed care in dermatology and the potential impact of PA requirements for novel topical therapies for psoriasis are considered.
  
  
  METHODS
  Using a model based on recent survey data, total annual cost estimates for a managed care organization to cover psoriasis treatment with a topical agent with or without PA requirements were calculated and compared. Costs for treatment and administrative costs associated with PA processes were included. The model assumed 68 000 insured patients required treatment (with an additional 1% to account for abuse/misuse), an average wholesale price of $100 per prescription (each prescription filled 4x/year), and a cost of $20 to process each PA request.
  
  
  RESULTS
  The total annual costs were $28 573 600 when PA was required and $27 472 000 when PA was not required. Thus, there was a total annual loss to the managed care organization of $1 101 600 associated with PA requirements.
  
  
  CONCLUSIONS
  Requiring PA for novel topical treatments for psoriasis, such as the new two-compound product containing calcipotriene and betamethasone dipropionate (Taclonex((R)); Warner Chilcott (US), Inc.; marketed as Daivobet((R))/Dovobet((R)) outside US by LEO Pharma), is not likely to be cost-effective for a managed care organization.
authors.affiliation: Center for Medication Use, Policy, and Economics, University of Michigan, Ann Arbor, MI 48109-1065, USA. rbalkris@umich.edu
authors.forename: Rajesh
authors.initials: R
authors.lastname: Balkrishnan
authors.forename: Monali J
authors.initials: MJ
authors.lastname: Bhosle
authors.forename: Alan B
authors.initials: AB
authors.lastname: Fleischer
authors.forename: Steven R
authors.initials: SR
authors.lastname: Feldman
mesh_terms: D000287:Administration, Topical; D017046:Cost Savings; D003362:Cost-Benefit Analysis / Q000379:methods; D003879:Dermatologic Agents / Q000191:economics* / Q000627:therapeutic use; D016527:Drug Costs / Q000706:statistics & numerical data; D011307:Drug Prescriptions / Q000191:economics; D005260:Female; D017048:Health Care Costs; D019538:Health Care Surveys; D006801:Humans; D008297:Male; D008329:Managed Care Programs / Q000191:economics* / Q000592:standards; D018803:Models, Economic; D011565:Psoriasis / Q000175:diagnosis / Q000188:drug therapy* / Q000191:economics*; D014481:United States
chemical_list: D003879:Dermatologic Agents