title: Novel approaches for mechanistic understanding and predicting preeclampsia.
abstract: Despite intense investigation, preeclampsia (PE) remains largely enigmatic. Relatively late onset of diagnostic signs and heterogeneous nature of the disease further contribute to poor understanding of its etiology and clinical management. There exist no concrete animal models that can provide mechanistic underpinnings for evaluating targeted therapeutic intervention. Poor cross-sectional findings with potential biochemical markers reported so far have proved counterintuitive and suggest a need for novel approaches to predict the early onset of disease. Because of the co-onset of local placental anomalies and systemic manifestation of symptoms, it is highly likely that serum from PE patients can provide a "blueprint" of causative factors. Proteomic and/or functional analysis of maternal serum are expected to predict the onset of disease ahead of manifestation of clinical symptoms. A serum-based predictive assay should overcome complexities resulting from the heterogeneous etiology of PE. This review attempts to address some of these issues and discuss the signature biochemical serum factors and propose new and better ways to predict PE.
authors.affiliation: Department of Pediatrics, Women and Infants Hospital-Warren Alpert Medical School of Brown University, Providence, RI, USA.
authors.forename: Satyan
authors.initials: S
authors.lastname: Kalkunte
authors.forename: Zhongbin
authors.initials: Z
authors.lastname: Lai
authors.forename: Wendy E
authors.initials: WE
authors.lastname: Norris
authors.forename: Linda A
authors.initials: LA
authors.lastname: Pietras
authors.forename: Neetu
authors.initials: N
authors.lastname: Tewari
authors.forename: Roland
authors.initials: R
authors.lastname: Boij
authors.forename: Stefan
authors.initials: S
authors.lastname: Neubeck
authors.forename: Udo R
authors.initials: UR
authors.lastname: Markert
authors.forename: Surendra
authors.initials: S
authors.lastname: Sharma
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood*; D005260:Female; D006801:Humans; D010929:Placentation; D011225:Pre-Eclampsia / Q000175:diagnosis / Q000209:etiology / Q000473:pathology; D011247:Pregnancy; D011379:Prognosis; D040901:Proteomics; D012698:Serologic Tests
chemical_list: D015415:Biomarkers