title: The catalytic asymmetric addition of alkyl- and aryl-zinc reagents to an isoxazole aldehyde.
abstract: Nucleophilic addition of alkyl- and aryl zinc reagents to a C(4) functionalized isoxazolyl aldehyde proceeded effectively with high enantioselectivity (85-94% e.e.). The amino alcohol catalyst (S)-2-piperidinyl-1,1,2-triphenyl ethanol (10) afforded the (R)-product 2b, as established by x-ray crystallography.
authors.affiliation: Department of Chemistry, University of Idaho, Moscow ID 83844-2343 USA.
authors.forename: Jared K
authors.initials: JK
authors.lastname: Nelson
authors.forename: Brendan
authors.initials: B
authors.lastname: Twamley
authors.forename: Trinidad J
authors.initials: TJ
authors.lastname: Villalobos
authors.forename: Nicholas R
authors.initials: NR
authors.lastname: Natale