Role of HDAC1 in senescence, aging, and cancer.
HDAC1 is a member of the class I of histone deacetylases that also includes HDAC2, -3 and -8. Although HDAC1 has been mostly studied in the context of cancer, recent evidence strongly suggests that it plays critical roles in cellular senescence, aging of the liver, myelination, and adult neurogenesis. Here we review such roles and discuss the entangled relationships between HDAC1 with histone acetyltransferases and other HDACs including SIRT1.
Willis-Martinez
Danielle
D
Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA.
Richards
Hunter W
HW
Timchenko
Nikolai A
NA
Medrano
Estela E
EE
D000375:Aging / Q000502:physiology*; D000818:Animals; D016922:Cellular Senescence / Q000502:physiology*; D056284:Histone Deacetylase 1 / Q000502:physiology*; D006657:Histones / Q000502:physiology; D006801:Humans; D051379:Mice; D009186:Myelin Sheath / Q000502:physiology; D009369:Neoplasms / Q000503:physiopathology*; D055495:Neurogenesis / Q000502:physiology
D006657:Histones; D056284:Histone Deacetylase 1