title: Clinical outcome of newly diagnosed Crohn's disease: a comparative, retrospective study before and after infliximab availability.
abstract: BACKGROUND
  Infliximab (IFX) could change the course of Crohn's disease (CD) by reducing steroid use, surgery or prompting earlier introduction of immunomodulators (IMM).
  
  
  OBJECTIVE
  To evaluate the impact of IFX availability on the course of early CD.
  
  
  METHODS
  Two cohorts of newly diagnosed CD patients were identified: The first cohort included patients diagnosed from January 1994 to December 1997 and the second from January 2000 to December 2003. All patients were diagnosed, treated and followed up in the same centre until December 1999 (first cohort) or December 2005 (second cohort). Development of disease-related complications, steroid, IMM or IFX requirements and intestinal resections during follow-up were registered.
  
  
  RESULTS
  A total of 328 patients were included (146 first cohort, 182 second cohort). A similar proportion of patients in both cohorts received steroids, but steroid exposure resulted significantly more intense in the first cohort (P = 0.001). In the second cohort, 14% of patients received IFX. Thiopurines were used more (P = 0.001) and earlier (P = 0.012) in the second cohort. No differences in surgical requirements or the development of disease-related complications were found.
  
  
  CONCLUSIONS
  Following a step-up therapeutic algorithm, IFX availability did not reduce surgical requirements or the development of disease-related complications.
authors.affiliation: Hospital Universitari Germans Trias i Pujol, Badalona, Catalonia, Spain. edomenech.germanstrias@gencat.cat
authors.forename: E
authors.initials: E
authors.lastname: Domènech
authors.forename: Y
authors.initials: Y
authors.lastname: Zabana
authors.forename: E
authors.initials: E
authors.lastname: Garcia-Planella
authors.forename: A
authors.initials: A
authors.lastname: López San Román
authors.forename: P
authors.initials: P
authors.lastname: Nos
authors.forename: D
authors.initials: D
authors.lastname: Ginard
authors.forename: J
authors.initials: J
authors.lastname: Gordillo
authors.forename: F
authors.initials: F
authors.lastname: Martínez-Silva
authors.forename: B
authors.initials: B
authors.lastname: Beltrán
authors.forename: M
authors.initials: M
authors.lastname: Mañosa
authors.forename: E
authors.initials: E
authors.lastname: Cabré
authors.forename: M A
authors.initials: MA
authors.lastname: Gassull
mesh_terms: D000328:Adult; D000465:Algorithms; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D003424:Crohn Disease / Q000150:complications / Q000188:drug therapy*; D005260:Female; D005765:Gastrointestinal Agents / Q000627:therapeutic use*; D006801:Humans; D000069285:Infliximab; D008297:Male; D011379:Prognosis; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D000911:Antibodies, Monoclonal; D005765:Gastrointestinal Agents; D000069285:Infliximab