title: Distribution of human papillomavirus type 58 variants in progression of cervical dysplasia in Korean women.
abstract: This cross-sectional study examined the distribution of HPV 58 sequence variation in Korean women for the first time. Among 1,750 Korean women, 53 women were positive for HPV 58 single infection, of whom 26 were without disease, 20 were with cervical intraepithelial neoplasia (CIN) 1, and 7 with CIN 2 or 3. Altogether, 36 different nucleotide sequence variations were identified with the L1, 20 within E2, 5 within E6, and 10 within E7. Further studies on variants of oncogenic HPVs are necessary, particularly for the purpose of developing more predictive HPV detection methods.
authors.affiliation: Department of Obstetrics and Gynecology, The Catholic University of Korea, Seoul, Korea.
authors.forename: Jeong-Hoon
authors.initials: JH
authors.lastname: Bae
authors.forename: Jo L K
authors.initials: JL
authors.lastname: Cheung
authors.forename: Sung-Jong
authors.initials: SJ
authors.lastname: Lee
authors.forename: Alfred C S
authors.initials: AC
authors.lastname: Luk
authors.forename: Seo-Yun
authors.initials: SY
authors.lastname: Tong
authors.forename: Paul K S
authors.initials: PK
authors.lastname: Chan
authors.forename: Jong-Sup
authors.initials: JS
authors.lastname: Park
mesh_terms: D052685:Alphapapillomavirus / Q000235:genetics* / Q000302:isolation & purification; D018450:Disease Progression; D005260:Female; D005814:Genes, Viral / Q000235:genetics; D014644:Genetic Variation; D006801:Humans; D007723:Korea; D030361:Papillomavirus Infections / Q000453:epidemiology*; D020641:Polymorphism, Single Nucleotide; D002578:Uterine Cervical Dysplasia / Q000150:complications / Q000821:virology*; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology / Q000235:genetics / Q000821:virology