title: Common variable immunodeficiency (CVID): case report and review of the literature.
abstract: Common variable immunodeficiency (CVID) is an immunodeficiency disease characterized by diminished ability to produce immunoglobulins. CVID has an estimated incidence of 1:10,000 to 1:200,000 (male:female 1:1) and usually presents in the second and third decade, although it also has a peak of incidence in childhood. The exact pathophysiology remains unclear. CVID can be associated with autoimmune, granulomatous and gastrointestinal diseases and patients have a predisposition to malignancies (especially non-Hodgkin lymphoma). Since different organ systems can be affected, all clinicians need to be aware of this entity, especially when confronted with patients with recurrent infections and/or multiple autoimmune diseases.
authors.affiliation: University Hospital Leuven, Department of General Internal Medicine, Herestraat 49, 3000 Leuven, Belgium. Philip.roelandt@uz.kuleuven.be
authors.forename: Ph R
authors.initials: PR
authors.lastname: Roelandt
authors.forename: D
authors.initials: D
authors.lastname: Blockmans
mesh_terms: D000328:Adult; D000888:Antibodies, Anti-Idiotypic / Q000097:blood* / Q000276:immunology; D017074:Common Variable Immunodeficiency / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000276:immunology*; D017565:Sarcoidosis, Pulmonary / Q000150:complications* / Q000175:diagnosis / Q000276:immunology; D014057:Tomography, X-Ray Computed
chemical_list: D000888:Antibodies, Anti-Idiotypic; D007136:Immunoglobulins