Ionic liquid mediated and promoted eco-friendly preparation of thiazolidinone and pyrimidine nucleoside-thiazolidinone hybrids and their antiparasitic activities.
Without any catalyst, 2,3-disubstituted-1,3-thiazolidin-4-one derivatives were synthesized efficiently via the three-component reaction of aldehyde, amine and mercaptoacetic acid in [bmim][PF(6)]. The whole procedure is simple and straightforward and no aqueous work-up is needed. By employing this protocol, a series of novel pyrimidine nucleoside-thiazolidin-4-one hybrids were prepared and their preliminary antiparasitic activities were also studied and reported.
Zhang
Xinying
X
School of Chemistry and Environmental Sciences, Henan Key Laboratory for Environmental Pollution Control, Henan Normal University, Xinxiang, Henan 453007, PR China.
Li
Xiaoyan
X
Li
Dongfang
D
Qu
Guirong
G
Wang
Jianji
J
Loiseau
Philippe M
PM
Fan
Xuesen
X
D000447:Aldehydes / Q000737:chemistry; D000588:Amines / Q000737:chemistry; D000977:Antiparasitic Agents / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D002626:Chemistry, Pharmaceutical; D020650:Combinatorial Chemistry Techniques / Q000379:methods; D015195:Drug Design; D052578:Ionic Liquids; D008956:Models, Chemical; D015394:Molecular Structure; D011741:Pyrimidine Nucleosides / Q000737:chemistry*; D013696:Temperature; D014665:Vasodilator Agents / Q000737:chemistry
D000447:Aldehydes; D000588:Amines; D000977:Antiparasitic Agents; D052578:Ionic Liquids; D011741:Pyrimidine Nucleosides; D014665:Vasodilator Agents