title: Proliferative nodules in a giant congenital melanocytic nevus-case report and review of the literature.
abstract: Malignant transformation of giant congenital nevi (GCN) is very rare, but may already occur in childhood. Benign proliferative nodules in GCN may clinically and histologically mimic a malignant melanoma. We report a newborn infant with large proliferative nodules and multiple satellite nevi in a GCN of the bathing suit type. The diagnosis in our patient was based on the smooth transition of the pre-existing lesion and the nodule, the absence of strong atypical nuclei, the atypical mitotic figures, the ascension of melanocytes in the epidermis and the absence of necrosis. A review of the literature showed that the clinical and the histological features of benign (proliferative) nodules are variable. The awareness and the identification of this entity by clinicians and pathologist are imperative to prevent diagnostic errors.
authors.affiliation: Department of Dermatology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. a.h.van.houten @derm.umcg.nl
authors.forename: Annemarie H
authors.initials: AH
authors.lastname: van Houten
authors.forename: Marcory C R F
authors.initials: MC
authors.lastname: van Dijk
authors.forename: Marie-Louise A
authors.initials: ML
authors.lastname: Schuttelaar
mesh_terms: D002471:Cell Transformation, Neoplastic; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009508:Nevus, Pigmented / Q000151:congenital* / Q000473:pathology*; D012878:Skin Neoplasms / Q000151:congenital* / Q000473:pathology*