Protective effects of isoliquiritigenin against methamphetamine-induced neurotoxicity in mice.
Isoliquiritigenin (ISL) suppresses cocaine-induced extracellular dopamine levels and has a neuroprotective effect in cocaine-treated rat brain. Here, we examine the effect of ISL on methamphetamine-induced striatal neurotoxicity. Repeated injections of methamphetamine cause the loss of striatal dopamine transporter (DAT) and tyrosine hydroxylase (TH). Intraperitoneal injection of ISL prior to methamphetamine injection significantly prevented methamphetamine-induced reduction of DAT and TH. ISL also suppressed methamphetamine-induced activation of glial cells. Moreover, ISL impeded the expression of nitric oxide synthase and the activation of NF-kappaB through blockage of its phosphorylation. Our results suggest that ISL protects against methamphetamine-induced neurotoxicity by inhibition of NF-kappaB activation.
Lee
Min Jung
MJ
Department of Physiology, Daegu Haany University, Daegu, South Korea.
Yang
Chae Ha
CH
Jeon
Jae-Pil
JP
Hwang
Meeyul
M
D000818:Animals; D047188:Chalcones / Q000494:pharmacology*; D003342:Corpus Striatum / Q000187:drug effects; D019610:Cytoprotection; D050483:Dopamine Plasma Membrane Transport Proteins / Q000378:metabolism; D007150:Immunohistochemistry; D008297:Male; D008694:Methamphetamine / Q000037:antagonists & inhibitors* / Q000633:toxicity; D051379:Mice; D008810:Mice, Inbred C57BL; D009457:Neuroglia / Q000187:drug effects; D020258:Neurotoxicity Syndromes / Q000378:metabolism*; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
D047188:Chalcones; D050483:Dopamine Plasma Membrane Transport Proteins; D008694:Methamphetamine; C040920:isoliquiritigenin; D014446:Tyrosine 3-Monooxygenase