Characteristics of embryo development in Robertsonian translocations' preimplantation genetic diagnosis cycles.
OBJECTIVE
To explore the embryo development characteristics in Robertsonian translocations (RTs) in their preimplantation genetic diagnosis (PGD) cycles.


METHODS
A total of 37 RT carrier couples underwent 41 blastomere PGD cycles from August 2005 to September 2008. The development of 272 embryos was analyzed in their PGD cycles.


RESULTS
At D3, there were 161 high-grade embryos, including 59 normal/balanced embryos and 102 abnormal embryos. There was no difference between the normal/balanced embryo group and the abnormal embryo group in terms of the high-grade embryo percentage (64.84% vs 56.35%, p = 0.179). However, at D5-D6, the blastocyst percentage in the normal/balanced embryo group was significantly higher than that in the abnormal embryo group (43.96% vs 20.44%, p = 0.000).


CONCLUSIONS
Normal/balanced embryos developed better and a self-selective mechanism may exist in the RTs' embryos at the blastocyst formation stage.
Huang
Jin
J
Reproductive Medicine Center, Peking University Third Hospital, Beijing 100191, China.
Lian
Ying
Y
Qiao
Jie
J
Chen
Yongjian
Y
Ren
Xiulian
X
Liu
Ping
P
D000328:Adult; D002478:Cells, Cultured; D025063:Chromosome Disorders / Q000175:diagnosis / Q000196:embryology / Q000235:genetics; D002901:Chromosomes, Human, 13-15; D002904:Chromosomes, Human, 21-22 and Y; D046149:Embryo Culture Techniques; D004622:Embryo, Mammalian / Q000002:abnormalities / Q000166:cytology; D047108:Embryonic Development / Q000235:genetics / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011247:Pregnancy; D011256:Pregnancy Outcome; D019836:Preimplantation Diagnosis / Q000379:methods*; D014178:Translocation, Genetic; D055815:Young Adult