[Recent advances in the study of bioreductive drugs targeted tumor hypoxia].
Tumor hypoxia is the necessary process in the development of solid tumors, which is the key factor for drug resistance, recurrence, attack and shift of tumor. Hypoxic tumor cells have a certain extent of tolerance to radiation and chemotherapy. Tumor hypoxia is an important target for medication therapy. In the recent years, the bioreductive drugs targeted tumor hypoxia has made great process in the treatment of tumors. The latest advances of bioreductive drugs targeted hypoxia were reviewed in this paper.
Liu
Jing-Bao
JB
Department of Medicinal Chemistry, College of Pharmaceutical Sciences, Shanghai Jiaotong University, Shanghai 200240, China.
Fu
Lei
L
Hu
Yong-Zhou
YZ
Jiang
Fa-Qin
FQ
D000970:Antineoplastic Agents / Q000627:therapeutic use; D015687:Cell Hypoxia; D006801:Humans; D000860:Hypoxia; D009369:Neoplasms / Q000188:drug therapy*; D011809:Quinones / Q000627:therapeutic use; D019163:Reducing Agents / Q000627:therapeutic use
D000970:Antineoplastic Agents; D011809:Quinones; D019163:Reducing Agents