Rapid viral diagnosis for acute febrile respiratory illness in children in the Emergency Department.
BACKGROUND
Pediatric acute respiratory infections (ARIs) represent a significant burden on pediatric emergency departments (ED) and families. Most of these illnesses are due to viruses. However, investigations (radiography, blood and urine testing) to rule out bacterial infections and antibiotics are often ordered because of diagnostic uncertainties. This results in prolonged ED visits and unnecessary antibiotic use. The risk of concurrent bacterial infection has been reported to be negligible in children over three months of age with a confirmed viral infection. Rapid viral testing in the ED may alleviate the need for precautionary testing and antibiotic use.


OBJECTIVE
To determine the effect of rapid viral testing in the ED on the rate of precautionary testing, antibiotic use and ED length of visit.


METHODS
We searched the Cochrane Central register of Controlled Trials (CENTRAL) (The Cochrane Library, 2009, issue 1) which contains the ARI Group's Specialized Register, MEDLINE (1950 to April Week 3 2009), EMBASE (1988 to Week 16, 2009), MEDLINE In-Process & Other Non-Indexed Citations (April 27, 2009), HealthStar (1966 to 2009), BIOSIS Previews (1969 to 2009), CAB Abstracts (1973 to 2007), CBCA Reference (1970 to 2007), and Proquest Dissertations and Theses (1861 to 2009).


METHODS
Randomized controlled trials (RCTs) of rapid viral testing for children with ARIs in the ED.


METHODS
Two review authors used the inclusion criteria to select trials, evaluate their quality and extract data. Missing data were obtained from trial authors. Differences in rate of investigations and antibiotics use were expressed as risk ratios (RR) and difference in ED length of visits was expressed as mean difference, with 95% confidence interval (CI).


RESULTS
Four trials were included, three RCTs and one quazi-RCT, with 759 children in the rapid viral testing and 829 in the control group. Rapid viral testing did not reduce antibiotic use in the ED significantly, neither clinically nor statistically. We found lower rates of chest radiography (RR 0.77, 95% CI 0.65 to 0.91) in the rapid viral testing group but no effect on length of ED visits, blood or urine testing in the ED.


CONCLUSIONS
Current evidence is insufficient, although promising, to support routine rapid viral testing as a means to reduce antibiotic use in pediatric EDs. Results suggest that rapid viral testing may be beneficial but are not statistically significant due to lack of power. A large trial addressing these outcome measures is needed.
Doan
Quynh
Q
Emergency Department, British Columbia Children's Hospital, 4500 Oak Street, Vancouver, British Columbia, Canada, V6H 3N1.
Enarson
Paul
P
Kissoon
Niranjan
N
Klassen
Terry P
TP
Johnson
David W
DW
D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000175:diagnosis; D002648:Child; D004636:Emergency Service, Hospital; D005334:Fever / Q000821:virology*; D006801:Humans; D007223:Infant; D007902:Length of Stay; D013902:Radiography, Thoracic / Q000706:statistics & numerical data; D016032:Randomized Controlled Trials as Topic; D012141:Respiratory Tract Infections / Q000821:virology*; D014777:Virus Diseases / Q000175:diagnosis*
D000900:Anti-Bacterial Agents