title: The use of D-dimer with new cutoff can be useful in diagnosis of venous thromboembolism in pregnancy.
abstract: OBJECTIVE
  D-dimer testing has an important role in the exclusion of acute venous thromboembolism (VTE) in the nonpregnant population. Establishing D-dimers role in the diagnosis of VTE in pregnancy is hampered because of the substantial increase of D-dimer throughout gestational age.
  
  
  METHODS
  In a prospective study we followed 89 healthy pregnant women to establish the reference range of D-dimer for each trimester. D-dimer testing was also performed in 12 women with clinical suspicion of VTE and their results were compared with the established new reference range of D-dimer, and with the recorded ultrasound findings.
  
  
  RESULTS
  In the first trimester, 84% women from reference group had normal D-dimer, in the second 33%, and by the third trimester only 1%, which suggests that D-dimer has no practical diagnostic use in ruling out VTE if the threshold of 230 ng/mL for abnormal is used. All pregnant women with thrombosis who had positive ultrasound findings also had statistically significant elevation of the D-dimer level, considering the established reference range of the corresponding trimester. We found 100% sensitivity of D-dimer test. A women developed thrombosis in the first trimester had 6.7-7.6 time higher level of D-dimer than the mean value in the reference group, and in the third trimester thrombotic women had 2.0-3.8 time higher level of D-dimer, p<0.0001.
  
  
  CONCLUSIONS
  D-dimer test with the new threshold for: the first of 286, the second of 457 and the third trimester of 644 ng/mL can be useful in diagnosis of pregnancy related VTE.
authors.affiliation: Blood Transfusion Institute of Serbia, Belgrade, Serbia.
authors.forename: Mirjana
authors.initials: M
authors.lastname: Kovac
authors.forename: Zeljko
authors.initials: Z
authors.lastname: Mikovic
authors.forename: Ljiljana
authors.initials: L
authors.lastname: Rakicevic
authors.forename: Snezana
authors.initials: S
authors.lastname: Srzentic
authors.forename: Vesna
authors.initials: V
authors.lastname: Mandic
authors.forename: Valentina
authors.initials: V
authors.lastname: Djordjevic
authors.forename: Dragica
authors.initials: D
authors.lastname: Radojkovic
authors.forename: Ivo
authors.initials: I
authors.lastname: Elezovic
mesh_terms: D000328:Adult; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis*; D006801:Humans; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000175:diagnosis*; D011261:Pregnancy Trimester, First; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D011446:Prospective Studies; D012016:Reference Values; D054556:Venous Thromboembolism / Q000175:diagnosis*
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D