Neuroleptic malignant syndrome and serotonin syndrome in a female patient: a clinicopathologic case.
We report the case of a 24-year-old female patient who initially developed a neuroleptic malignant syndrome after haloperidol exposure and experienced 6 years later a serotonin syndrome after repeated fluoxetine exposure. The patient did not respond to symptomatic treatment and died in this latter episode. At necropsy, no gross or microscopic changes were seen with conventional histological stains, and immunohistochemical stains were negative. This is the first clinicopathologic case of a patient who experienced both neuroleptic malignant and serotonin syndromes. We speculate that this case argue in favor that both syndromes share some fundamental pathogenetic mechanisms.
Gómez-Esteban
Juan Carlos
JC
Department of Neuroscience, University of the Basque Country (UPV/EHU), Neurology Service, Hospital de Cruces, Baracaldo, Vizcaya, Spain. jgomeze@meditex.es
Barcena
Joseba
J
Forcadas
Maribel
M
Somme
Johanne
J
Agundez
Marta
M
Tijero
Beatriz
B
Zarranz
Juan J
JJ
D017809:Fatal Outcome; D005260:Female; D005473:Fluoxetine / Q000009:adverse effects; D006220:Haloperidol / Q000009:adverse effects; D006801:Humans; D009459:Neuroleptic Malignant Syndrome / Q000150:complications* / Q000473:pathology*; D020230:Serotonin Syndrome / Q000139:chemically induced / Q000150:complications* / Q000473:pathology*; D055815:Young Adult
D005473:Fluoxetine; D006220:Haloperidol