[The effect of mycophenolate mofetil and azathioprine on gingival enlargement associated with cyclosporin A use in kidney transplant patients].
OBJECTIVE
To assess gingival overgrowth prevalence and severity in a group of kidney transplant (KT) patients, and analyze the effect of immunosuppressor drugs Cyclosporin A (CsA), Tacrolimus (Tac), Sirolimus (Siro), Azathioprine (Aza) and Mofetil Mycophenolate on this complication.


METHODS
Gingival overgrowth presence and severity was classified, and the impact of immunosuppressor drugs, age, oral hygiene, verapamil and nifedipine on this condition was analyzed by multiple logistic regression.


RESULTS
172 KT pts. were examined; 137 used CsA, 25 Tac, 6 Sirolimus, 107 Aza and 56 MMF. Gingival overgrowth prevalence was 59.1% on CsA, 12.0% on Tac, and 16.7% on Sirolimus. CsA odds ratio (OR) 15.2, age <45 OR 5.6, and poor oral hygiene OR 3.2, increased, and Aza OR 0.05 and MMF OR 0.03, decreased GO prevalence.


CONCLUSIONS
Aza and MMF effect was a significant protection against GO prevalence in this group of KT patients.
de la Rosa García
E
E
Departamento de Atención a la Salud, Universidad Autónoma Metropolitana Xoch, Servicio de Nefrología, Hospital General de Zona 50, Instituto Mexicano del Seguro Social, San Luis Potosi, México. delarosa0712@msn.com
Mondragón Padilla
A
A
D000328:Adult; D001379:Azathioprine / Q000009:adverse effects*; D003430:Cross-Sectional Studies; D016572:Cyclosporine / Q000009:adverse effects*; D005260:Female; D005886:Gingival Hypertrophy / Q000139:chemically induced* / Q000453:epidemiology; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016030:Kidney Transplantation; D008297:Male; D009173:Mycophenolic Acid / Q000009:adverse effects / Q000031:analogs & derivatives*; D012720:Severity of Illness Index
D007166:Immunosuppressive Agents; D016572:Cyclosporine; D009173:Mycophenolic Acid; D001379:Azathioprine