title: 3,5-Isoxazoles from alpha-bromo-pentafluorophenyl vinylsulfonates: synthesis of sulfonates and sulfonamides.
abstract: The regioselective 1,3-dipolar cycloaddition of alpha-bromo-pentafluorophenyl vinylsulfonate with nitrile oxides has been used to rapidly access a range of 3,5-isoxazoles which could be converted directly to their corresponding sulfonamides.
authors.affiliation: Department of Chemistry, University College London, Christopher Ingold Laboratories, 20 Gordon Street, London, UK WC1H 0AJ.
authors.forename: Chieh Chien
authors.initials: CC
authors.lastname: Lee
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Fitzmaurice
authors.forename: Stephen
authors.initials: S
authors.lastname: Caddick
mesh_terms: D007555:Isoxazoles / Q000737:chemistry*; D008872:Microwaves; D009570:Nitriles / Q000737:chemistry; D013237:Stereoisomerism; D013379:Substrate Specificity; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000737:chemistry; D013451:Sulfonic Acids / Q000138:chemical synthesis* / Q000737:chemistry*; D014753:Vinyl Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D005464:Fluorobenzenes; D005466:Fluorocarbons
chemical_list: D007555:Isoxazoles; D009570:Nitriles; D013449:Sulfonamides; D013451:Sulfonic Acids; D014753:Vinyl Compounds; C478988:pentafluorophenyl vinylsulfonate; D005464:Fluorobenzenes; D005466:Fluorocarbons