title: Long-term suppression of GABAergic activity by neonatal seizures in rat somatosensory cortex.
abstract: Here we studied the long-term effects of neonatal seizures on inhibitory synaptic transmission in somatosensory cortex. We found that recurrent flurothyl-induced seizures result in a marked reduction in amplitude of spontaneous inhibitory postsynaptic currents (IPSCs) and increases of miniature IPSCs interevent intervals. These results indicate that decreasing the inhibitory synaptic strength following neonatal seizures in neocortical neurons is not due to a postsynaptic mechanism.
authors.affiliation: Department of Neurology, Neuroscience Center at Dartmouth, Dartmouth Medical School, Lebanon, NH, USA. olena.isaeva@gmail.com
authors.forename: Elena
authors.initials: E
authors.lastname: Isaeva
authors.forename: Dmytro
authors.initials: D
authors.lastname: Isaev
authors.forename: Rustem
authors.initials: R
authors.lastname: Khazipov
authors.forename: Gregory L
authors.initials: GL
authors.lastname: Holmes
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D005481:Flurothyl / Q000633:toxicity; D053444:Inhibitory Postsynaptic Potentials / Q000502:physiology*; D055369:Miniature Postsynaptic Potentials / Q000502:physiology*; D009433:Neural Inhibition / Q000502:physiology; D009474:Neurons / Q000378:metabolism / Q000502:physiology*; D018408:Patch-Clamp Techniques; D051381:Rats; D017207:Rats, Sprague-Dawley; D012640:Seizures / Q000139:chemically induced / Q000378:metabolism / Q000503:physiopathology*; D013003:Somatosensory Cortex / Q000378:metabolism / Q000503:physiopathology*; D009435:Synaptic Transmission / Q000502:physiology; D013995:Time; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
chemical_list: D005680:gamma-Aminobutyric Acid; D005481:Flurothyl