Chiral biphenylamide derivative: an efficient organocatalyst for the enantioselective synthesis of alpha-hydroxy phosphonates.
The aldol reactions of alpha-keto phosphonates and aldehydes were facilitated by an axially chiral biphenylprolinamide under mild conditions, affording the synthetically and pharmaceutically useful products in high yields and excellent enantioselectivities.
Jiang
Jun
J
Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, China.
Chen
Xiaohong
X
Wang
Jun
J
Hui
Yonghai
Y
Liu
Xiaohua
X
Lin
Lili
L
Feng
Xiaoming
X
D000447:Aldehydes / Q000737:chemistry; D000813:Anilides / Q000737:chemistry*; D001713:Biphenyl Compounds / Q000737:chemistry*; D002384:Catalysis; D063065:Organophosphonates / Q000138:chemical synthesis* / Q000737:chemistry*; D011392:Proline / Q000737:chemistry; D013237:Stereoisomerism; D013379:Substrate Specificity
D000447:Aldehydes; D000813:Anilides; D001713:Biphenyl Compounds; D063065:Organophosphonates; C116609:3-hydroxybutanal; D011392:Proline