title: Gliomatosis cerebri type II: two case reports.
abstract: BACKGROUND
  TWO TYPES OF GLIOMATOSIS CEREBRI EXIST: Type I and Type II. We report the results of a histological and genetic study of two cases of gliomatosis cerebri Type II, correlating these results with therapy and prognosis.
  
  
  METHODS
  Two patients, a 52-year-old man (Patient 1) and a 76-year-old man (Patient 2) with gliomatosis cerebri II were admitted to our institution; they underwent surgical treatment and received radiotherapy and chemotherapy. At the 24-month follow-up, Patient 1 was still alive, while Patient 2 had died. The poor prognosis of Patient 2 was underlined by molecular analysis which showed that the angiogenesis related genes VCAM1 and VEGF were overexpressed, reflecting the high degree of neovascularization.
  
  
  CONCLUSIONS
  Genes involved in drug resistance and metallothioneins were highly expressed in Patient 2 and this, associated with unmethylated O6-methylguanine methyltransferase, can explain the lack of response to chemotherapy.
authors.forename: Pietro Ivo
authors.initials: PI
authors.lastname: D'Urso
authors.forename: Oscar Fernando
authors.initials: OF
authors.lastname: D'Urso
authors.forename: Santo
authors.initials: S
authors.lastname: Marsigliante
authors.forename: Carlo
authors.initials: C
authors.lastname: Storelli
authors.forename: Alessandro
authors.initials: A
authors.lastname: Distante
authors.forename: Francesca
authors.initials: F
authors.lastname: Sanguedolce
authors.forename: Antonia
authors.initials: A
authors.lastname: Cimmino
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Luzi
authors.forename: Cosimo Damiano
authors.initials: CD
authors.lastname: Gianfreda
authors.forename: Antonio
authors.initials: A
authors.lastname: Montinaro
authors.forename: Pasqualino
authors.initials: P
authors.lastname: Ciappetta