title: Effect of L-asparaginase combined with vincristine and prednisolone on acute myeloblastic leukemia (M0) associated with non-Hodgkin lymphoma.
abstract: A 66-year-old Japanese woman was referred to us because of severe anemia and fever and presented at our hospital. She was eventually diagnosed as having acute myeloblastic leukemia (AML; M0) with non-Hodgkin lymphoma (NHL). We investigated the therapeutic efficacy of L-asparaginase (L-Asp), vincristine and prednisolone for both her AML and NHL. Asparagine synthetase (AS) activity in her AML blast cells was undetectable. A lymph node biopsy specimen revealed NHL of the marginal zone B cell type. Complete remission (CR) of AML and NHL was achieved. CR of the AML lasted for 18 months without further consolidation therapy. We conclude that L-Asp can be an effective drug for the treatment of AML in which blasts are negative for AS.
authors.affiliation: Department of Internal Medicine, Nihon University Nerima Hikarigaoka Hospital, Tokyo, Japan. akhorik@med.nihon-u.ac.jp
authors.forename: Akira
authors.initials: A
authors.lastname: Horikoshi
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Takei
authors.forename: Noriyoshi
authors.initials: N
authors.lastname: Iriyama
authors.forename: Kumi
authors.initials: K
authors.lastname: Uenogawa
authors.forename: Hikaru
authors.initials: H
authors.lastname: Ishizuka
authors.forename: Hidetaka
authors.initials: H
authors.lastname: Shiraiwa
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Hosokawa
authors.forename: Shigemasa
authors.initials: S
authors.lastname: Sawada
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Kitoh
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001215:Asparaginase / Q000627:therapeutic use*; D001217:Aspartate-Ammonia Ligase / Q000378:metabolism; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy*; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy*; D011239:Prednisolone / Q000627:therapeutic use*; D012074:Remission Induction; D014750:Vincristine / Q000627:therapeutic use*
chemical_list: D014750:Vincristine; D011239:Prednisolone; D001215:Asparaginase; D001217:Aspartate-Ammonia Ligase