[Regulation of cortical cytoskeleton dynamics during migration of free-living amoebae].
Amoeba proteus and smaller by an order of magnitude (and evolutionary younger) Acanthamoeba castellanii have been for many years model cells for studies of amoeboidal (crawling) type of movement, characteristic also for some of metazoan cells such as fibroblasts, granulocytes and macrophages. Amoeboidal migration is indispensable of organization and dynamics of actin-based cytoskeleton. While there is a number of data on molecular mechanisms of motility of A. castellanii, there is very little known about bases of migration of A. proteus. Noteworthy, a large A. proteus (length approximately 600 microm) have been from over a century an object for studies on biology and physiology of cellular migration. This review describes the current knowledge on molecular aspects of force generation required for migration of these two amoebae and attempts to compare the functioning and regulation of actin cytoskeleton in these free-living unicellular species.
Kłopocka
Wanda
W
Zakład Biochemii, Instytut Biologii Doświadczalnej im. Marcelego Nenckiego PAN, Warszawa. w.klopocka@nencki.gov.pl
Redowicz
Maria Jolanta
MJ
Wasik
Anna
A
D048248:Acanthamoeba castellanii / Q000502:physiology; D000199:Actins / Q000378:metabolism; D000656:Amoeba / Q000502:physiology*; D000818:Animals; D002465:Cell Movement / Q000502:physiology*; D003599:Cytoskeleton / Q000502:physiology*
D000199:Actins