title: Synthesis and anticancer activity of novel amide derivatives of non-acetal deoxoartemisinin.
abstract: Novel amide derivatives of C-12 non-acetal deoxoartemisinin were synthesized. Some of the derivatives had potent in vitro anticancer activity against major human cancer cell lines. The deoxoartemisinin amide trimer had potent in vivo antiangiogenic activity, according to the mouse matrigel plug assay.
authors.affiliation: Department of Chemistry, Yonsei University, Seoul 120-749, Republic of Korea. mjung@yonsei.ac.kr
authors.forename: Mankil
authors.initials: M
authors.lastname: Jung
authors.forename: Namsoo
authors.initials: N
authors.lastname: Park
authors.forename: Hyung-In
authors.initials: HI
authors.lastname: Moon
authors.forename: Yongnam
authors.initials: Y
authors.lastname: Lee
authors.forename: Won-Yoon
authors.initials: WY
authors.lastname: Chung
authors.forename: Kwang-Kyun
authors.initials: KK
authors.lastname: Park
mesh_terms: D000080:Acetals / Q000737:chemistry; D000577:Amides / Q000138:chemical synthesis / Q000737:chemistry*; D000818:Animals; D017209:Apoptosis / Q000187:drug effects / Q000502:physiology; D037621:Artemisinins / Q000138:chemical synthesis* / Q000737:chemistry; D049109:Cell Proliferation; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D004730:Endothelium, Vascular / Q000187:drug effects / Q000473:pathology; D006801:Humans; D020128:Inhibitory Concentration 50; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D013329:Structure-Activity Relationship
chemical_list: D000080:Acetals; D000577:Amides; D037621:Artemisinins; C063801:deoxoartemisinin