Features of intrathecal immunoglobulins in patients with multiple sclerosis.
We have analyzed immunoglobulin (Ig) isotypes and IgG subclasses in cerebrospinal fluid (CSF) and serum of patients with multiple sclerosis (MS) and other neurological diseases to determine whether different Ig isotype patterns correlate with clinical or paraclinical findings and CSF B cell populations. Intrathecal IgG1 synthesis was elevated in MS patients. An increased intrathecal IgM production was found in patients with a higher cerebral MRI lesion burden, whereas other clinical and paraclinical parameters were not associated with a specific Ig isotype or subclass profile. Finally, intrathecal IgG production (IgG1 and IgG3) correlated with the presence of mature B cells and plasma blasts.
Di Pauli
Franziska
F
Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35, A-6020 Innsbruck, Austria.
Gredler
Viktoria
V
Kuenz
Bettina
B
Lutterotti
Andreas
A
Ehling
Rainer
R
Gneiss
Claudia
C
Schocke
Michael
M
Deisenhammer
Florian
F
Reindl
Markus
M
Berger
Thomas
T
D000293:Adolescent; D000328:Adult; D001402:B-Lymphocytes; D002555:Cerebrospinal Fluid / Q000166:cytology; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007074:Immunoglobulin G / Q000134:cerebrospinal fluid; D007136:Immunoglobulins / Q000134:cerebrospinal fluid*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000134:cerebrospinal fluid* / Q000473:pathology; D009422:Nervous System Diseases / Q000134:cerebrospinal fluid; D055815:Young Adult
D007074:Immunoglobulin G; D007136:Immunoglobulins