title: In vitro study of antibacterial activity on multi-resistant bacteria and chemical composition of the chloroform extract of endemic Centaurea drabifolia subsp. cappadocica.
abstract: The antimicrobial activity of the n-hexane, chloroform, ethyl acetate and ethanol extracts of the aerial parts of C. drabifolia S.M. subsp. cappadocica (DC.) Wagenitz (Asteraceae) was evaluated against microorganisms including multi-antibiotic resistant bacteria using the paper disc diffusion method. The chemical composition of the chloroform extract of this plant was determined by gas chromatography and gas chromatography-mass spectrometry. The chloroform extract exhibited significant antibacterial activity against all the bacteria tested, except Stenotrophomonas maltophilia MU63. The major compounds of the chloroform extract were spathulenol (14.1%), caryophyllene oxide (12.5%), octadecanol (10.2%), ethyl palmitate (7.7%), [Z,Z]-10,12-hexadecadienal (6.0%), 3-hydroxy p-anisaldehyde (5.9%) and pentacosane (5.8%).
authors.affiliation: Department of Biology, Faculty of Arts and Sciences, Mugla University, Mugla TR 48121, Turkey. ayselugur@hotmail.com
authors.forename: Aysel
authors.initials: A
authors.lastname: Ugur
authors.forename: Nurdan
authors.initials: N
authors.lastname: Sarac
authors.forename: M Emin
authors.initials: ME
authors.lastname: Duru
authors.forename: Yavuz
authors.initials: Y
authors.lastname: Beyatli
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects* / Q000254:growth & development; D031179:Centaurea / Q000737:chemistry*; D024901:Drug Resistance, Multiple, Bacterial; D008401:Gas Chromatography-Mass Spectrometry; D005779:Immunodiffusion; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D010936:Plant Extracts; D013729:Terpenes