[Calcium regulation of cell migration].
Cell migration is a phenomenon requiring close regulation of numerous biochemical processes. Motile cells have to orchestrate countless symultanous biochemical pathways as well as properly react to change in environment, and respond to stimuli generated by other cells. One of the most universal ways of subcellular information transmission is a system based on changes in concentration of cytoplasmic free calcium ion. The article summarizes the current knowledge on the role of calcium signalling in regulation of the processes indispensable of cell migration such as actomyosin contractility, cell adhesion and cytoskeleton dynamics. The possible influence of mechanical effects of cell motility on emerging of calcium signal is also discussed.
Pomorski
Paweł
P
Zakład Biochemii, Instytut Biologii Doświadczalnej im. M. Nenckiego PAN, Warszawa. p.pomorski@nencki.gov.pl
D000205:Actomyosin / Q000502:physiology; D002118:Calcium / Q000378:metabolism*; D020013:Calcium Signaling / Q000502:physiology; D002448:Cell Adhesion / Q000502:physiology; D002465:Cell Movement / Q000502:physiology*; D003593:Cytoplasm / Q000378:metabolism*
D000205:Actomyosin; D002118:Calcium