A new way to classify genetic skin disease.
Genetic disorders with skin manifestations often affect other organs as well, and diseases with a similar array of features might be linked pathogenetically. Classifying disorders by individual phenotypic components may reveal clusters with a common genetic cause and elucidate pathogenic links. If components are categorized inadequately, however, the method will simply confirm what is known, obscure true links, and suggest false ones.
Moss
Celia
C
Department of Dermatology, Birmingham Children's Hospital, Birmingham, UK. celia.moss@bch.nhs.uk
D030342:Genetic Diseases, Inborn / Q000145:classification* / Q000235:genetics*; D006801:Humans; D010641:Phenotype; D012871:Skin Diseases / Q000145:classification* / Q000235:genetics*