title: Empty sella and primary autoimmune hypothyroidism.
abstract: In order to assess the association between empty sella (ES) and primary autoimmune hypothyroidism, and the possibility of a common pathogenesis. We retrospectively studied all patients with presumed ES diagnosed in the last 20 years, most of whom were treated by our Endocrinology Department. Subjects with a known etiology were excluded. Incomplete records or those with a doubtful diagnosis were also excluded. A total of 56 subjects were included in the study. ES was diagnosed by pituitary MRI. The measurement of free T4, TSH, and antithyroid antibodies (TPOAb and TgAb) was assayed using commercial kits. The cases of hypothyroidism obtained were compared with those in another group of similar patients, diagnosed with diabetes mellitus type 2, through chi2 test. A total of 15 (26.78%) patients of 56 with ES had autoimmune thyroid disease (subclinical or clinical hypothyroidism). Primary hypothyroidism with negative antithyroid autoantibodies was found in a further 13 patients (23.21%). The 46.42% of ES had primary hypothyroidism; this result had obtained a statistically significant difference when compared to the ratio obtained in the group of diabetes mellitus type 2 (P < 0.0029). There is an important association between ES and autoimmune thyroid disease, which reached 26.78% in our series. We suggest the possibility of a common pathogenesis for certain cases of ES and autoimmune thyroid disease, with the end point of ES in the pituitary, and atrophy in the thyroid gland.
authors.affiliation: Department of Endocrinology, Hospital General Universitario Gregorio Marañón, Avenida Doctor Esquerdo, 46, 28007 Madrid, Spain. roges82@msn.com
authors.forename: Rogelio
authors.initials: R
authors.lastname: García-Centeno
authors.forename: José Pablo
authors.initials: JP
authors.lastname: Suárez-Llanos
authors.forename: Elisa
authors.initials: E
authors.lastname: Fernández-Fernández
authors.forename: Victor
authors.initials: V
authors.lastname: Andía-Melero
authors.forename: Petra
authors.initials: P
authors.lastname: Sánchez
authors.forename: Antonino
authors.initials: A
authors.lastname: Jara-Albarrán
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001323:Autoantibodies / Q000097:blood; D001327:Autoimmune Diseases / Q000453:epidemiology*; D015897:Comorbidity; D004652:Empty Sella Syndrome / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000453:epidemiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011859:Radiography; D012189:Retrospective Studies; D012658:Sella Turcica / Q000000981:diagnostic imaging; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood
chemical_list: D001323:Autoantibodies; D013972:Thyrotropin; D013974:Thyroxine