Therapeutic vaccination and novel strategies to treat chronic HBV infection.
Therapeutic vaccination for the treatment of chronic hepatitis B has so far shown limited clinical efficacy. In this review, we argue that the principal cause of this failure is the profound defect of virus-specific T cells present in chronic hepatitis B patients and we discuss potential new ways to achieve an efficient restoration of virus-specific immunity in patients with chronic hepatitis B virus infection.
Bertoletti
Antonio
A
Viral Hepatitis Laboratory, Singapore Institute for Clinical Science, Agency of Science Technology and Research, and Program on Emerging Infectious Diseases, Duke-NUS Graduate Medical School, Singapore. antonio_bertoletti@sics.a-star.edu.sg
Gehring
Adam
A
D017325:Hepatitis B Vaccines / Q000627:therapeutic use*; D006515:Hepatitis B virus / Q000276:immunology*; D019694:Hepatitis B, Chronic / Q000276:immunology / Q000628:therapy*; D006801:Humans; D007113:Immunity, Innate; D016176:T-Lymphocyte Subsets / Q000276:immunology* / Q000821:virology; D017211:Treatment Failure; D016896:Treatment Outcome
D017325:Hepatitis B Vaccines