title: Natural infection with canine distemper virus in hand-feeding Rhesus monkeys in China.
abstract: An outbreak of canine distemper virus (CDV) in hand-feeding Rhesus monkeys in China was reported. Twenty Rhesus monkeys presented blood and mucus in feces, respiratory symptoms, anorexia, acute fever, thicken of footpad and red rashes in the faces over 1-month period. CDV infection was identified by characteristic clinical signs, the specific detection of the BIT Rapid color CDV detection kit, electron microscopy and the results of sequence aligning. A phylogenetic analysis further confirmed that the CDV in the Rhesus monkeys belonged to the clade of the epidemic CDV types of China. All the infected monkeys were monitored and treated with antiserum therapy. The antiserum therapy seemed more effective for adult monkeys than young monkeys. Twelve monkeys died. The high mortality might indicate that the virulence of CDV to monkeys was enhanced. This is the first report we are aware of documenting Rhesus monkeys infected with CDV in China. Urgent work should be done to prevent the possibly epidemic of CDV in non-human primate.
authors.affiliation: Laboratory Animal Center of the Academy of Military Medical Science, No. 20, Dongdajie Street, Fengtai District, Beijing 100071, China.
authors.forename: Zhaozeng
authors.initials: Z
authors.lastname: Sun
authors.forename: Aixue
authors.initials: A
authors.lastname: Li
authors.forename: Huahu
authors.initials: H
authors.lastname: Ye
authors.forename: Yansheng
authors.initials: Y
authors.lastname: Shi
authors.forename: Zhongming
authors.initials: Z
authors.lastname: Hu
authors.forename: Lin
authors.initials: L
authors.lastname: Zeng
mesh_terms: D000818:Animals; D002681:China; D004216:Distemper / Q000175:diagnosis / Q000473:pathology* / Q000821:virology; D004217:Distemper Virus, Canine / Q000235:genetics / Q000302:isolation & purification / Q000502:physiology* / Q000648:ultrastructure; D005248:Feeding Methods / Q000662:veterinary; D008253:Macaca mulatta; D008969:Molecular Sequence Data; D008992:Monkey Diseases / Q000175:diagnosis / Q000473:pathology* / Q000821:virology; D019590:Nucleocapsid Proteins / Q000235:genetics; D010802:Phylogeny; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012689:Sequence Homology, Nucleic Acid
chemical_list: D019590:Nucleocapsid Proteins