title: X-linked variation in immune response in Drosophila melanogaster.
abstract: This study quantifies the effects of naturally occurring X-linked variation on immune response in Drosophila melanogaster to assess associations between immunity genotypes and innate immune response. We constructed a set of 168 X-chromosomal extraction lines, incorporating X chromosomes from a natural population into co-isogenic autosomal backgrounds, and genotyped the lines at 88 SNPs in 20 X-linked immune genes. We find that genetic variation in many of the genes is associated with immune response phenotypes, including bacterial load and immune gene expression. Many of the associations act in a sex-specific or sexually antagonistic manner, supporting the theory that with the selective pressures facing genes on the X chromosome, sexually antagonistic variation may be more easily maintained.
authors.affiliation: Field of Genetics and Development, Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA. erinhill@life.bio.sunysb.edu
authors.forename: Erin M
authors.initials: EM
authors.lastname: Hill-Burns
authors.forename: Andrew G
authors.initials: AG
authors.lastname: Clark
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000276:immunology; D004331:Drosophila melanogaster / Q000235:genetics* / Q000276:immunology* / Q000382:microbiology; D005260:Female; D050172:Genes, X-Linked / Q000235:genetics*; D014644:Genetic Variation; D005838:Genotype; D008297:Male; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D012727:Sex Characteristics; D013045:Species Specificity; D015533:Transcriptional Activation / Q000276:immunology