title: [Interleukin-1 cytokines, inflammasomes, NOD-signalosomes and autoinflammation].
abstract: The understanding of the genetic and immunological basis of human periodic fever syndromes, in particular cryopyrin-associated periodic syndromes (CAPS), has led to important new insights into the pathogenesis of monogenic and complex interleukin-1beta-associated autoinflammatory diseases. Currently the focus of attention is on the nucleotide-binding oligomerization domain (NOD)-like receptors (NLR), which take part in the regulation of the synthesis and maturation of cytokines in the IL-1 families, NOD-signalosomes and inflammasomes.
authors.affiliation: Division of Infection, Inflammation & Immunity, Southampton General Hospital, School of Medicine, University of Southampton, Southampton, UK. s.gadola@soton.ac.uk
authors.forename: S D
authors.initials: SD
authors.lastname: Gadola
mesh_terms: D000818:Animals; D016207:Cytokines / Q000276:immunology*; D056660:Hereditary Autoinflammatory Diseases / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D007155:Immunologic Factors / Q000276:immunology*; D007375:Interleukin-1 / Q000276:immunology*; D018448:Models, Immunological; D053472:Nod Signaling Adaptor Proteins / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology*
chemical_list: D016207:Cytokines; D007155:Immunologic Factors; D007375:Interleukin-1; D053472:Nod Signaling Adaptor Proteins