title: HPV 6/11, 16, 18 seroprevalence in men in two US cities.
abstract: BACKGROUND
  A vaccine to prevent human papillomavirus (HPV) 6, HPV 11, HPV 16, or HPV 18 and associated diseases is licensed for females, and it may be licensed for men in the future. There are limited data on HPV 6/11, 16, and/or 18 seroprevalence in men.
  
  
  METHODS
  A total of 490 men aged 18 to 40 years were enrolled in a study of HPV in men in Tucson, AZ, and Tampa, FL. Enrolled men completed a self-administered questionnaire, and HPV serology was performed using HPV 6/11, 16, and 18 VLP assays.
  
  
  RESULTS
  Overall, seroprevalence to HPV 16 was 12.1%, HPV 6/11 was 9.7%, and to HPV 18 was 5.4%. Seroprevalence to HPV 6/11, 16, and/or 18 was 21% and was highest among 35 to 40 year olds (48%); prevalence in this age group was significantly higher compared to the 18 to 24 year olds (adjusted odds ratio (aOR) 6.8, 95% confidence interval (CI) 3.7, 12.8). Independent predictors of seropositivity to HPV 6/11, 16, and/or 18 were older age, greater number of female sex partners in the past 3 months, and current smoking.
  
  
  CONCLUSIONS
  HPV vaccine-type seroprevalence was highest in 35 to 40 year old men. These data on the epidemiology of HPV seroprevalence in men are useful for discussions regarding recommendations for HPV vaccine if licensed for use in men.
authors.affiliation: Division of STD Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA.
authors.forename: Eileen F
authors.initials: EF
authors.lastname: Dunne
authors.forename: Carrie M
authors.initials: CM
authors.lastname: Nielson
authors.forename: Michael E
authors.initials: ME
authors.lastname: Hagensee
authors.forename: Mary R
authors.initials: MR
authors.lastname: Papenfuss
authors.forename: Robin B
authors.initials: RB
authors.lastname: Harris
authors.forename: Nicholas
authors.initials: N
authors.lastname: Herrel
authors.forename: Jennifer
authors.initials: J
authors.lastname: Gourlie
authors.forename: Martha
authors.initials: M
authors.lastname: Abrahamsen
authors.forename: Lauri E
authors.initials: LE
authors.lastname: Markowitz
authors.forename: Anna R
authors.initials: AR
authors.lastname: Giuliano
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000914:Antibodies, Viral / Q000097:blood; D001130:Arizona / Q000453:epidemiology; D005260:Female; D005431:Florida / Q000453:epidemiology; D020010:Heterosexuality; D052140:Human papillomavirus 11 / Q000276:immunology*; D052162:Human papillomavirus 16 / Q000276:immunology*; D052161:Human papillomavirus 18 / Q000276:immunology*; D006801:Humans; D008297:Male; D010212:Papilloma / Q000097:blood / Q000453:epidemiology*; D030361:Papillomavirus Infections / Q000097:blood / Q000453:epidemiology*; D053918:Papillomavirus Vaccines / Q000276:immunology; D012307:Risk Factors; D016036:Seroepidemiologic Studies; D012747:Sexual Partners; D011795:Surveys and Questionnaires; D014505:Urban Population
chemical_list: D000914:Antibodies, Viral; D053918:Papillomavirus Vaccines