title: Characterization of a WiT49 cell line derived orthotopic model of Wilms tumor.
abstract: Wilms tumor is the most common malignant renal tumor in children. However, to date no Wilms tumor mouse model is available due to the lack of Wilms tumor cell lines. Herein for the first time we report an orthotopic xenograft mouse model utilizing the recently described Wilms tumor cell line WiT49. It has a high tumor occurrence rate (85%) without metastasis. Hematoxylin and eosin staining showed it is subcapsular in location and mainly biphasic with stromal and epithelial components while blastemal component is unappreciable. This model provides the prerequisite for the screening and development of new anti-tumor agents for Wilms tumor.
authors.affiliation: Center for Vascular Biology, University of Connecticut Health Center, Farmington, Connecticut, USA.
authors.forename: Mei-Hong
authors.initials: MH
authors.lastname: Li
authors.forename: Harold
authors.initials: H
authors.lastname: Yamase
authors.forename: Fernando
authors.initials: F
authors.lastname: Ferrer
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D004195:Disease Models, Animal; D008297:Male; D051379:Mice; D008819:Mice, Nude; D009396:Wilms Tumor / Q000473:pathology