title: Deceptively simple but simply deceptive--Caenorhabditis elegans lifespan studies: considerations for aging and antioxidant effects.
abstract: The nematode worm Caenorhabditis elegans (C. elegans) is increasingly popular as a model organism for aging studies as well as for testing antioxidants and other compounds for effects on longevity. However, results in the literature are sometimes confusing and contradictory. This review introduces C. elegans as a model organism, discusses aspects that make it attractive for aging and antioxidant research, and addresses some problems and potential artifacts.
authors.affiliation: Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
authors.forename: Jan
authors.initials: J
authors.lastname: Gruber
authors.forename: Li Fang
authors.initials: LF
authors.lastname: Ng
authors.forename: Suresh Kumar
authors.initials: SK
authors.lastname: Poovathingal
authors.forename: Barry
authors.initials: B
authors.lastname: Halliwell
mesh_terms: D000375:Aging / Q000187:drug effects / Q000502:physiology; D000818:Animals; D000975:Antioxidants / Q000378:metabolism* / Q000494:pharmacology; D017173:Caenorhabditis elegans / Q000502:physiology*; D006801:Humans; D008017:Life Expectancy; D008136:Longevity / Q000187:drug effects
chemical_list: D000975:Antioxidants