Reproductive and developmental toxicity evaluation of a purified Arabinogalactan-Protein (AGP) composition in Wistar rats.
A purified Arabinogalactan-Protein composition (LL-4218) was prepared from the leaves of Argemone mexicana to treat psoriasis. The effect of (LL-4218) was evaluated on reproductive (male and female fertility) and developmental toxicity in rats. LL-4218 was administered orally at the doses of 250, 500 and 1000 mg kg(-1). The results showed that LL-4218 did not produce any significant dose related changes in reproductive and developmental toxicity studies. Therefore, it is concluded that LL-4218 did not produce any significant toxic effect on reproduction and developmental parameters of rats and NOAEL for reproductive and developmental toxicity studies in rats was 1000 mg kg(-1).
Tamboli
Salim
S
Novel Drug Discovery and Development (NDDD), Lupin Ltd., 46A/47A, Nande Village, Mulshi Taluka, Pune 411042, India.
Arora
Sudershan
S
Bhatnagar
Upendra
U
Vishwase
Gururaj
G
Singh
Minakshi
M
D000818:Animals; D031674:Argemone / Q000737:chemistry*; D005260:Female; D005298:Fertility / Q000187:drug effects*; D047109:Fetal Development / Q000187:drug effects*; D005685:Galactans / Q000302:isolation & purification / Q000633:toxicity*; D008297:Male; D010936:Plant Extracts / Q000737:chemistry / Q000633:toxicity*; D010940:Plant Proteins / Q000302:isolation & purification / Q000633:toxicity*; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar
D005685:Galactans; D010936:Plant Extracts; D010940:Plant Proteins; C005653:arabinogalactan