Three isostructural solvates of finasteride and their solid-state characterization.
Three crystalline hemi-hydrate, channel solvates (classified as solvates from here on) of finasteride (N-(1,1-di-methylethyl)-3-oxo-4-aza-5 alpha-androst-1-ene-17beta-carboxamide) have been obtained and fully characterized. The acetone, methyl ethyl ketone (MEK), and toluene solvates of finasteride, described herein, were found to be isostructural and belong as additional members to a family of previously reported finasteride solvates. Vacuum drying at 85 degrees C for 1 day produced the metastable, anhydrous Form II of finasteride from all three solvated materials.
Schultheiss
Nate
N
SSCI, A Division of Aptuit, 3065 Kent Avenue, West Lafayette, IN 47906, USA. nathan.schultheiss@aptuit.com
Smit
Jared P
JP
Hanko
Jason A
JA
D002626:Chemistry, Pharmaceutical / Q000379:methods*; D018120:Finasteride / Q000032:analysis / Q000737:chemistry*; D019999:Pharmaceutical Solutions / Q000737:chemistry; D012995:Solubility; D012997:Solvents; D013237:Stereoisomerism; D014961:X-Ray Diffraction / Q000379:methods
D019999:Pharmaceutical Solutions; D012997:Solvents; D018120:Finasteride