The R753Q polymorphism abrogates toll-like receptor 2 signaling in response to human cytomegalovirus.
Toll-like receptor 2 (TLR2) serves as a pattern recognition receptor that signals the presence of cytomegalovirus. Herein, we report that R753Q polymorphism paralyzes TLR2-mediated immune signaling in cells exposed to cytomegalovirus glycoprotein B. This immunologic impairment could serve as a biologic mechanism underlying the association between the TLR2 R753Q polymorphism and cytomegalovirus disease in humans.
Brown
Robert A
RA
Division of Infectious Diseases, College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.
Gralewski
Jonathon H
JH
Razonable
Raymund R
RR
D015153:Blotting, Western; D002460:Cell Line; D003587:Cytomegalovirus / Q000276:immunology* / Q000378:metabolism*; D005434:Flow Cytometry; D006023:Glycoproteins / Q000276:immunology; D006801:Humans; D016209:Interleukin-8 / Q000378:metabolism; D016328:NF-kappa B / Q000378:metabolism; D011110:Polymorphism, Genetic / Q000235:genetics*; D051195:Toll-Like Receptor 2 / Q000235:genetics / Q000502:physiology*; D014764:Viral Proteins / Q000276:immunology
D006023:Glycoproteins; D016209:Interleukin-8; D016328:NF-kappa B; D051195:Toll-Like Receptor 2; D014764:Viral Proteins