Mathematical analysis of the long-term efficacy of daily home hemodialysis therapy with a cold dialysate regeneration system.
OBJECTIVE
We previously developed the cold dialysate regeneration system (CDRS) for use in daily home hemodialysis (HD). This study evaluates the long-term efficacy of the CDRS using a mathematical method.


METHODS
HD with the CDRS was simulated using a method that integrates the mass-transfer model and the dialyzer solute kinetics model with a newly proposed model of CDRS function.


RESULTS
We mathematically assessed the long-term efficacy of HD with the CDRS. The weekly treatment time required for HD with the CDRS was reduced significantly using the daily dialysis method; it required only an 11% longer treatment time to obtain the corrected equivalent renal clearance and a 14% shorter time for the standard Kt/V, compared with thrice weekly treatment with conventional HD.


CONCLUSIONS
By developing a mathematical model to test the long-term efficacy of the new CDRS, we showed that HD with the CDRS is an efficient means of daily home hemodialysis therapy.
Lim
Ki Moo
KM
Department of Mechanical and Biomedical Engineering, Kangwon National University, Chuncheon, Korea.
Kim
Ji Hyun
JH
Shim
Eun Bo
EB
D003080:Cold Temperature; D015314:Dialysis Solutions / Q000378:metabolism; D006437:Hemodialysis, Home / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy; D008962:Models, Theoretical; D014508:Urea / Q000378:metabolism
D015314:Dialysis Solutions; D014508:Urea