title: DNA-hydrolyzing Ab: is catalytic activity a clue for physiological significance?
abstract: Ab with DNA-hydrolyzing properties were described in autoimmune pathologies, such as SLE and RA, and in other autoimmune diseases, including chronic lymphocytic leukemia, AIDS, and others. The disease-associated DNA-binding AAb penetrate cell membrane and enter the nucleus. Intracellular entry of anti-DNA was linked to cellular damage and apo. Here we discuss the possible pathological process induced by DNA-cleaving Ab in the nucleus, where these Ab may induce apo. Apo processes, e.g., induced by DNA-hydrolyzing Ab, may underlie a number of syndromes observed in autoimmunity thus providing the grounds for the pathological role of DNA-hydrolyzing Ab in these diseases.
authors.affiliation: M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, UI, Miklukho-Maklaya Street, 16/10, 117997 GSP, Moscow, V-437, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Kozyr
authors.forename: A G
authors.initials: AG
authors.lastname: Gabibov
mesh_terms: D017151:Antibodies, Catalytic / Q000276:immunology*; D017209:Apoptosis / Q000276:immunology*; D001323:Autoantibodies / Q000276:immunology; D001324:Autoantigens / Q000276:immunology; D001327:Autoimmune Diseases / Q000201:enzymology / Q000276:immunology*; D015551:Autoimmunity / Q000276:immunology*; D004247:DNA / Q000276:immunology*; D006801:Humans
chemical_list: D017151:Antibodies, Catalytic; D001323:Autoantibodies; D001324:Autoantigens; D004247:DNA