Effects of artemisinin derivative on the growth metabolism of Tetrahymena thermophila BF5 based on expression of thermokinetics.
The toxic effects of artesunate and dihydroartemisinin on the growth metabolism of Tetrahymena thermophila BF5 were studied by microcalorimetry. The results showed that: (1) low concentrations of artesunate (<or=1 mg L(-1)) and dihydroartemisinin (<or= 2 mg L(-1)) promoted the growth metabolism of T. thermophila BF5, whereas high concentrations of artesunate (1-60 mg L(-1)) and dihydroartemisinin (2-60 mg L(-1)) inhibited its growth; (2) the half inhibition concentrations IC(50) of artesunate and dihydroartemisinin were 17.5817 and 9.5089 mg L(-1), respectively. It was concluded that the inhibition of dihydroartemisinin was stronger than that of artesunate.
Shen
Xue-Song
XS
College of Pharmacy, Guilin Medical University, Guilin, Guangxi, 541004, People's Republic of China. shenmedxs@163.com
Su
Qi
Q
Qiu
Zhuang-ping
ZP
Xu
Jing-yi
JY
Xie
Yan-xia
YX
Liu
Han-fu
HF
Liu
Yi
Y
D000818:Animals; D037621:Artemisinins / Q000494:pharmacology*; D000077332:Artesunate; D002151:Calorimetry; D016808:Tetrahymena thermophila / Q000187:drug effects* / Q000254:growth & development
D037621:Artemisinins; D000077332:Artesunate; C039060:artenimol