title: Effects of artemisinin derivative on the growth metabolism of Tetrahymena thermophila BF5 based on expression of thermokinetics.
abstract: The toxic effects of artesunate and dihydroartemisinin on the growth metabolism of Tetrahymena thermophila BF5 were studied by microcalorimetry. The results showed that: (1) low concentrations of artesunate (<or=1 mg L(-1)) and dihydroartemisinin (<or= 2 mg L(-1)) promoted the growth metabolism of T. thermophila BF5, whereas high concentrations of artesunate (1-60 mg L(-1)) and dihydroartemisinin (2-60 mg L(-1)) inhibited its growth; (2) the half inhibition concentrations IC(50) of artesunate and dihydroartemisinin were 17.5817 and 9.5089 mg L(-1), respectively. It was concluded that the inhibition of dihydroartemisinin was stronger than that of artesunate.
authors.affiliation: College of Pharmacy, Guilin Medical University, Guilin, Guangxi, 541004, People's Republic of China. shenmedxs@163.com
authors.forename: Xue-Song
authors.initials: XS
authors.lastname: Shen
authors.forename: Qi
authors.initials: Q
authors.lastname: Su
authors.forename: Zhuang-ping
authors.initials: ZP
authors.lastname: Qiu
authors.forename: Jing-yi
authors.initials: JY
authors.lastname: Xu
authors.forename: Yan-xia
authors.initials: YX
authors.lastname: Xie
authors.forename: Han-fu
authors.initials: HF
authors.lastname: Liu
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000818:Animals; D037621:Artemisinins / Q000494:pharmacology*; D000077332:Artesunate; D002151:Calorimetry; D016808:Tetrahymena thermophila / Q000187:drug effects* / Q000254:growth & development
chemical_list: D037621:Artemisinins; D000077332:Artesunate; C039060:artenimol