Reversible dissolution of glutathione-mediated HgSe(x)S(1-x) nanoparticles and possible significance in Hg-Se antagonism.
A new pathway is proposed for the in vivo biomineralization of HgSe(x)S(1-x)(s) (0 < x < or = 1), which is thought to be the ultimate metabolic product responsible for the Hg-Se antagonism in biological systems. The pathway involves the reaction of inorganic Hg(II) with selenite in the presence of glutathione (GSH). The resulting GSH-mediated HgSe(x)S(1-x) nanoclusters are reversibly soluble depending on the pH, which might have played a role in the distribution pattern of HgSe(x)S(1-x)(s) in different tissues. The HgSe species involved and the nature of bonding were studied by UV-visible spectroscopy, infrared spectroscopy, microprobe scanning electron microscopy, transmission electron microscopy, X-ray diffraction, and X-ray photoelectron spectroscopy.
Khan
Mohammad A K
MA
Department of Chemistry, University of Manitoba, Winnipeg, Manitoba R3T 2N2, Canada.
Wang
Feiyue
F
D005978:Glutathione / Q000737:chemistry*; D008628:Mercury / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D056951:Photoelectron Spectroscopy; D012643:Selenium / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D014961:X-Ray Diffraction
D008628:Mercury; D005978:Glutathione; D012643:Selenium