title: Solid phase synthesis of acylglycine human metabolites.
abstract: Acylglycines represents a large and important class of human metabolites. They are often used in medicine to identify fatty acid oxidation disorders. A highly efficient solid phase synthesis approach to obtain these clinically important compounds is developed via coupling reaction between glycine-preloaded Wang resin and a set of carboxylic acids. The developed methodology facilitates the preparation of several structurally-diverse acylglycines with high yields and purity.
authors.affiliation: Department of Biological Sciences, University of Alberta, Edmonton, AB, Canada. perezpin@ualberta.ca
authors.forename: Rolando
authors.initials: R
authors.lastname: Perez-Pineiro
authors.forename: Ying Wei
authors.initials: YW
authors.lastname: Dong
authors.forename: David S
authors.initials: DS
authors.lastname: Wishart
mesh_terms: D005998:Glycine / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000378:metabolism*; D006801:Humans; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D005998:Glycine