title: Chronic actions of thyroxine on behavior and serotonin receptors in mouse strains with contrasting predispositions to catalepsy.
abstract: The studies reported here addressed the effects of chronic administration of thyroxine (2 mg/liter for 60 days) on catalepsy and the functional activity and expression of the 5-HT(1A) and 5-HT(2A) receptor genes in the brains of adult male mice of the cataleptic ASC strain and the catalepsy-resistant AKR strain. Thyroxine induced cataleptics in AKR mice but had anticataleptic activity in ASC animals. Chronic thyroxine administration increased the functional activity and expression of 5-HT(2A) receptors in the frontal cortex in AKR mice but not in ASC mice. In ASC mice, the hormone significantly weakened the hypothermic effect of the 5-HT(1A) receptor agonist 8-OH-DPAT, though it did not alter the expression of these receptors. These results suggest that 5-HT(2A) receptors are involved in the cataleptogenic while 5-HT(1A) receptors are involved in the anticataleptic effects of the hormone in mice.
authors.affiliation: Novosibirsk State University, Novosibirsk, Russia. zubkov@ngs.ru
authors.forename: E A
authors.initials: EA
authors.lastname: Zubkov
authors.forename: A V
authors.initials: AV
authors.lastname: Kulikov
authors.forename: V S
authors.initials: VS
authors.lastname: Naumenko
authors.forename: N K
authors.initials: NK
authors.lastname: Popova
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002375:Catalepsy / Q000188:drug therapy / Q000503:physiopathology*; D005625:Frontal Lobe / Q000378:metabolism; D007036:Hypothermia, Induced; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR; D044282:Receptor, Serotonin, 5-HT1A / Q000378:metabolism*; D044402:Receptor, Serotonin, 5-HT2A / Q000378:metabolism*; D058825:Serotonin 5-HT1 Receptor Agonists; D058826:Serotonin 5-HT2 Receptor Agonists; D013045:Species Specificity; D013974:Thyroxine / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D044402:Receptor, Serotonin, 5-HT2A; D058825:Serotonin 5-HT1 Receptor Agonists; D058826:Serotonin 5-HT2 Receptor Agonists; D044282:Receptor, Serotonin, 5-HT1A; D013974:Thyroxine