title: Mathematical analysis of the long-term efficacy of daily home hemodialysis therapy with a cold dialysate regeneration system.
abstract: OBJECTIVE
  We previously developed the cold dialysate regeneration system (CDRS) for use in daily home hemodialysis (HD). This study evaluates the long-term efficacy of the CDRS using a mathematical method.
  
  
  METHODS
  HD with the CDRS was simulated using a method that integrates the mass-transfer model and the dialyzer solute kinetics model with a newly proposed model of CDRS function.
  
  
  RESULTS
  We mathematically assessed the long-term efficacy of HD with the CDRS. The weekly treatment time required for HD with the CDRS was reduced significantly using the daily dialysis method; it required only an 11% longer treatment time to obtain the corrected equivalent renal clearance and a 14% shorter time for the standard Kt/V, compared with thrice weekly treatment with conventional HD.
  
  
  CONCLUSIONS
  By developing a mathematical model to test the long-term efficacy of the new CDRS, we showed that HD with the CDRS is an efficient means of daily home hemodialysis therapy.
authors.affiliation: Department of Mechanical and Biomedical Engineering, Kangwon National University, Chuncheon, Korea.
authors.forename: Ki Moo
authors.initials: KM
authors.lastname: Lim
authors.forename: Ji Hyun
authors.initials: JH
authors.lastname: Kim
authors.forename: Eun Bo
authors.initials: EB
authors.lastname: Shim
mesh_terms: D003080:Cold Temperature; D015314:Dialysis Solutions / Q000378:metabolism; D006437:Hemodialysis, Home / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy; D008962:Models, Theoretical; D014508:Urea / Q000378:metabolism
chemical_list: D015314:Dialysis Solutions; D014508:Urea