title: Daily electrical silencing in the mammalian circadian clock.
abstract: Neurons in the brain's suprachiasmatic nuclei (SCNs), which control the timing of daily rhythms, are thought to encode time of day by changing their firing frequency, with high rates during the day and lower rates at night. Some SCN neurons express a key clock gene, period 1 (per1). We found that during the day, neurons containing per1 sustain an electrically excited state and do not fire, whereas non-per1 neurons show the previously reported daily variation in firing activity. Using a combined experimental and theoretical approach, we explain how ionic currents lead to the unusual electrophysiological behaviors of per1 cells, which unlike other mammalian brain cells can survive and function at depolarized states.
authors.affiliation: Faculty of Life Sciences, A. V. Hill Building, University of Manchester, Manchester M13 9PT, UK.
authors.forename: Mino D C
authors.initials: MD
authors.lastname: Belle
authors.forename: Casey O
authors.initials: CO
authors.lastname: Diekman
authors.forename: Daniel B
authors.initials: DB
authors.lastname: Forger
authors.forename: Hugh D
authors.initials: HD
authors.lastname: Piggins
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D020746:Calcium Channels, L-Type / Q000378:metabolism; D002940:Circadian Rhythm / Q000502:physiology*; D004553:Electric Conductivity; D055724:Electrophysiological Phenomena; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics / Q000378:metabolism*; D008564:Membrane Potentials; D051379:Mice; D008959:Models, Neurological; D009474:Neurons / Q000502:physiology*; D018408:Patch-Clamp Techniques; D056950:Period Circadian Proteins; D011188:Potassium / Q000378:metabolism; D024681:Potassium Channels, Calcium-Activated / Q000378:metabolism; D013493:Suprachiasmatic Nucleus / Q000166:cytology* / Q000502:physiology
chemical_list: D020746:Calcium Channels, L-Type; D047908:Intracellular Signaling Peptides and Proteins; C539023:Per1 protein, mouse; D056950:Period Circadian Proteins; D024681:Potassium Channels, Calcium-Activated; D011188:Potassium; D002118:Calcium