History of incidence of autoimmune and oncological diseases in identical female twins.
OBJECTIVE
The aim of study was to investigate identical female twins born in 1977 suffered from autoimmune diseases (twin A - Sjogren's syndrome, and twin B - systemic lupus erythematosus).


METHODS
It was refer retrospective analysis of both sisters suffered beside autoimmune alterations (Sjogren's syndrome and systemic lupus erythematosus) also from gynecological diseases (twin A - praecancerosis of cervix uteri, twin B - carcinoma vaginae).


RESULTS
Relationships between disease activities and severities in the female twins were similar and the treatments were directed according to clinical symptoms and laboratory results. Dramatic change, unfortunately, occurred with twin B. The reason may be the association between SLE activity (lupus nephritis), hematological complication (leukopenia) and oncological vaginal recidivation.


CONCLUSIONS
Association between autoimmune disease and gynecological cancer (or praecancerosis) is major risk than without immunology deviation. Twin A is periodically gynecologically observed.
Ulcova-Gallova
Z
Z
Department of Gynecology Obstetrics, Medical School of Charles University and University Hospital, Pilsen, Czech Republic. ulcova@fnplzen.cz
Brabcova
H
H
Kokes
V
V
Hradecky
L
L
Novotny
Z
Z
Rokyta
Z
Z
D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000150:complications* / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology; D036861:Delivery, Obstetric; D004200:Diseases in Twins; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology; D011230:Precancerous Conditions / Q000150:complications* / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology; D011247:Pregnancy; D012189:Retrospective Studies; D012859:Sjogren's Syndrome / Q000150:complications* / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology; D014430:Twins, Monozygotic; D002583:Uterine Cervical Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology; D014625:Vaginal Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology