title: Ischemic tolerance in stroke treatment.
abstract: Although outcome after stroke treatment has significantly improved over the last 30 years, there has been no revolutionary breakthrough. Among different combined approaches, systemic thrombolysis in combination with neuroprotection became a favorite research target. Recent studies suggest that transient ischemic attacks may represent a clinical model of such ischemic tolerance; thus, a new focus on this research has emerged. In this review, we show the parallels between ischemia and neuroprotection and discuss the potential therapeutic options that may be opened by this new molecular knowledge.
authors.affiliation: Department of Neurosurgery, University of Lausanne, Lausanne, Switzerland.
authors.forename: Nora
authors.initials: N
authors.lastname: Sandu
authors.forename: Jan
authors.initials: J
authors.lastname: Cornelius
authors.forename: Andreas
authors.initials: A
authors.lastname: Filis
authors.forename: Belachew
authors.initials: B
authors.lastname: Arasho
authors.forename: Miguel
authors.initials: M
authors.lastname: Perez-Pinzon
authors.forename: Bernhard
authors.initials: B
authors.lastname: Schaller
mesh_terms: D000818:Animals; D006801:Humans; D002546:Ischemic Attack, Transient / Q000188:drug therapy / Q000503:physiopathology*; D018696:Neuroprotective Agents / Q000627:therapeutic use; D020521:Stroke / Q000628:therapy*; D015912:Thrombolytic Therapy
chemical_list: D018696:Neuroprotective Agents