title: Imaging inflammation in real time--future of nanoparticles.
abstract: The detection of subclinical early inflammation in autoimmune diseases is an important but currently technically demanding approach to direct initial diagnosis and subsequent choice of therapy. Recent advances in imaging using NP provides the potential to detect cellular recruitment, vascular activation or leakage at a subclinically stage of disease and may provide predictive "biomarkers" of future pathogenesis. The NP used are either untargeted and taken up by phagocytic cells, or are linked to a ligand, targeting localisation to the site of inflammation. Techniques, varying from MRI and fluorescence to Raman spectroscopy are being employed. In this short review, we summarise many of the recent developments in the field of NP imaging related to inflammation.
authors.affiliation: Centre for Rheumatic Diseases, University of Glasgow, Glasgow, G12 8TA, UK. a.hueber@clinmed.gla.ac.uk
authors.forename: Axel J
authors.initials: AJ
authors.lastname: Hueber
authors.forename: Ross
authors.initials: R
authors.lastname: Stevenson
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Stokes
authors.forename: Duncan
authors.initials: D
authors.lastname: Graham
authors.forename: Paul
authors.initials: P
authors.lastname: Garside
authors.forename: Iain B
authors.initials: IB
authors.lastname: McInnes
mesh_terms: D000818:Animals; D003952:Diagnostic Imaging / Q000379:methods* / Q000639:trends*; D006801:Humans; D007249:Inflammation / Q000175:diagnosis*; D053758:Nanoparticles