title: [A case of unresectable hilar bile duct cancer responding to chemo-radiotherapy by gemcitabine].
abstract: A 66-year-old woman was admitted to our hospital because of general fatigue and icterus. PTC findings showed irregular stenosis of hilar bile duct. Abdominal CT scan showed a dilatation of the intra-hepatic bile duct and a tumor around hilar bile duct. We diagnosed it as hilar bile duct carcinoma, and although we operated it was unresectable because of the metastasis of a para-aorta lymph node and duodenal invasion. We started chemo-radiotherapy with a total dose of 45 Gy and gemcitabine. The tumor and para-aorta lymph node were remarkably decreased, and tumor marker CA 19-9 was also decreased to within the normal range. The patient had a peritoneal dissemination 10 months after the chemo-radiotherapy and survived 20 months.
authors.affiliation: Dept. of Surgery, Saga University Faculty of Medicine.
authors.forename: Naohiko
authors.initials: N
authors.lastname: Kohya
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Hashiguchi
authors.forename: Tomomi
authors.initials: T
authors.lastname: Yakabe
authors.forename: Atsushi
authors.initials: A
authors.lastname: Miyoshi
authors.forename: Takao
authors.initials: T
authors.lastname: Ohtsuka
authors.forename: Kenji
authors.initials: K
authors.lastname: Kitahara
authors.forename: Kohji
authors.initials: K
authors.lastname: Miyazaki
mesh_terms: D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D001650:Bile Duct Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000532:radiotherapy* / Q000601:surgery; D014408:Biomarkers, Tumor / Q000097:blood; D003131:Combined Modality Therapy; D003841:Deoxycytidine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004379:Duodenal Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000556:secondary; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D009361:Neoplasm Invasiveness; D011859:Radiography; D000093542:Gemcitabine
chemical_list: D000964:Antimetabolites, Antineoplastic; D014408:Biomarkers, Tumor; D003841:Deoxycytidine; D000093542:Gemcitabine