title: Serum prolidase activity and oxidative status in patients with stage I endometrial cancer.
abstract: BACKGROUND
  We aimed to investigate the serum prolidase activity, total oxidant status (TOS), total antioxidant capacity (TAC), and total free sulfhydryl (-SH) groups in patients with stage I endometrial cancer.
  
  
  METHODS
  Serum prolidase activity, TOS, TAC, and -SH levels were measured in patients with endometrial cancer (n = 23) and controls (n = 25).
  
  
  RESULTS
  Serum prolidase activity and TOS were significantly higher in patients with endometrial cancer than in controls (P = 0.02 and P = 0.02, respectively), whereas TAC and -SH group levels were significantly lower (P = 0.004 and P = 0.001, respectively). There were no differences between surgical stages IA and IB or between stages IB and IC (P = 0.189 and P = 0.161, respectively) with respect to prolidase levels, whereas there was a significant difference between stages IA and IC (P < 0.001).
  
  
  CONCLUSIONS
  Increased serum prolidase activity and oxidative stress may be associated with endometrial cancer, and increased serum prolidase activity may be related to local invasion of endometrial cancer.
authors.affiliation: Department of Obstetrics and Gynecology, Medical School, Afyonkarahisar Kocatepe University, Afyonkarahisar, Turkey. dagistantolgaarioz@yahoo.com
authors.forename: Dagistan Tolga
authors.initials: DT
authors.lastname: Arioz
authors.forename: Hakan
authors.initials: H
authors.lastname: Camuzcuoglu
authors.forename: Harun
authors.initials: H
authors.lastname: Toy
authors.forename: Sefa
authors.initials: S
authors.lastname: Kurt
authors.forename: Hakim
authors.initials: H
authors.lastname: Celik
authors.forename: Nurten
authors.initials: N
authors.lastname: Aksoy
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000097:blood / Q000378:metabolism; D018269:Carcinoma, Endometrioid / Q000097:blood* / Q000378:metabolism / Q000473:pathology*; D016022:Case-Control Studies; D004150:Dipeptidases / Q000097:blood* / Q000378:metabolism; D016889:Endometrial Neoplasms / Q000097:blood* / Q000378:metabolism / Q000473:pathology*; D005260:Female; D005609:Free Radicals / Q000097:blood / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D016877:Oxidants / Q000097:blood / Q000378:metabolism; D018384:Oxidative Stress / Q000502:physiology; D013438:Sulfhydryl Compounds / Q000097:blood / Q000378:metabolism
chemical_list: D000975:Antioxidants; D014408:Biomarkers, Tumor; D005609:Free Radicals; D016877:Oxidants; D013438:Sulfhydryl Compounds; D004150:Dipeptidases; C022449:proline dipeptidase