Outcome domains for studies of acute and chronic gout.
Discussion and voting at OMERACT 9 confirmed 5 essential domains for outcomes of acute gout: pain, joint swelling, joint tenderness, patient global assessment and activity limitations. For studies in chronic gout 7 essential domains are: serum urate, acute gout attacks, tophus burden, health-related quality of life, activity limitations, pain, and patient global assessment. Implications of patient perspectives, discretionary domains for specific studies, measurement instruments and a possible responder index are under study.
Schumacher
H Ralph
HR
Rheumatology Section, Veterans Affairs Medical Center, University & Woodland Avenues, Philadelphia, Pennsylvania 19104, USA. schumacr@mail.med.upenn.edu
Taylor
William
W
Edwards
Lawrence
L
Grainger
Rebecca
R
Schlesinger
Naomi
N
Dalbeth
Nicola
N
Sivera
Francisca
F
Singh
Jasvinder
J
Evans
Robert
R
Waltrip
Royce W
RW
Diaz-Torne
Cesar
C
MacDonald
Patricia
P
McQueen
Fiona
F
Perez-Ruiz
Fernando
F
D000208:Acute Disease; D018771:Arthralgia / Q000503:physiopathology; D002908:Chronic Disease; D032921:Consensus; D004185:Disability Evaluation; D006073:Gout / Q000175:diagnosis* / Q000503:physiopathology / Q000523:psychology; D006801:Humans; D017063:Outcome Assessment, Health Care / Q000592:standards*; D011788:Quality of Life; D012720:Severity of Illness Index; D014527:Uric Acid / Q000097:blood
D014527:Uric Acid