[The involvement of neprilysin in the pathogenesis of glomerulopathies].
Neprilysin (NEP, CD10, CALLA-common acute lymphoblastic leukaemia antigen, neutral endopeptidase, enkephalinase) is a zinc-dependent metallopeptidase, which is the first podocytic antigen, which has been shown to induce human membranous glomerulonephritis (GN). Debiec et al. in a case of antenatal membranous GN identified NEP as the podocyte target antigen of circulating antibodies produced by the mother who failed to express NEP on granulocytes. However, NEP is expressed on normal podocytes and renal proximal tubular epithelial cells. Moreover, decreased podocyte expression of NEP has been found in a variety of glomerular diseases. Recent studies show that in patients with GN the podocyte expression of NEP correlates with that of other podocyte proteins, i.e.: synaptopodin and CR1 and reflects the severity of glomerular damage.
Kubiak-Wlekły
Anna
A
Medical University of Poznan, Department of Nephrology, Transplantology and Internal Diseases, Laboratory for Molecular Nephrology, Poland.
Niemir
Zofia I
ZI
D000328:Adult; D004847:Epithelial Cells / Q000378:metabolism; D015433:Glomerulonephritis, Membranous / Q000378:metabolism*; D006801:Humans; D007674:Kidney Diseases / Q000378:metabolism; D007678:Kidney Glomerulus / Q000378:metabolism*; D015260:Neprilysin / Q000378:metabolism*; D050199:Podocytes / Q000378:metabolism
D015260:Neprilysin