title: The use of recombinant tissue plasminogen activator in the management of infective intracardiac thrombi in pre-term infants with thrombocytopaenia.
abstract: Bacterial endocarditis complicated by the development of intra-cardiac thrombus presents a difficult management dilemma in the pre-term infant. Here we present our experience with three infants who had this condition, all of whom were successfully managed using therapy with recombinant tissue plasminogen activator (r-TPA). Therapy in one of the infants was particularly instructive, as the condition was further complicated by severe thrombocytopaenia, making the decision to treat using r-TPA difficult.
authors.affiliation: Department of Paediatric Cardiology, Mater Children's Hospital, Brisbane, QLD, Australia.
authors.forename: Ben
authors.initials: B
authors.lastname: Anderson
authors.forename: Prasanth
authors.initials: P
authors.lastname: Urs
authors.forename: David
authors.initials: D
authors.lastname: Tudehope
authors.forename: Cameron
authors.initials: C
authors.lastname: Ward
mesh_terms: D003328:Coronary Thrombosis / Q000188:drug therapy* / Q000209:etiology; D004697:Endocarditis, Bacterial / Q000150:complications / Q000188:drug therapy*; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000188:drug therapy*; D008297:Male; D013203:Staphylococcal Infections / Q000150:complications / Q000188:drug therapy; D013921:Thrombocytopenia / Q000150:complications / Q000188:drug therapy*; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D005343:Fibrinolytic Agents; D010959:Tissue Plasminogen Activator