title: Hemolytic anemia after zopiclone overdose.
abstract: BACKGROUND
  Zopiclone is associated with methemoglobinemia. We report a case of zopiclone overdose manifested with another hematological complication, hemolysis.
  
  
  METHODS
  A 46-year-old woman overdosed with 50-100 tablets of 7.5 mg zopiclone. Oxidative hemolysis was evident by anemia, bite cells, raised unconjugated bilirubin and lactate dehydrogenase, lowered haptoglobin, and reticulocytosis.
  
  
  CONCLUSIONS
  In zopiclone overdose, there may be oxidative stress rendering the development of not only methemoglobinemia but also hemolysis.
authors.affiliation: Accident & Emergency Department, Tuen Mun Hospital, Hong Kong, China. funght@ha.org.hk
authors.forename: Hin Tat Jeffrey
authors.initials: HT
authors.lastname: Fung
authors.forename: Cing Hon
authors.initials: CH
authors.lastname: Lai
authors.forename: Oi Fung
authors.initials: OF
authors.lastname: Wong
authors.forename: Shing Kit Tommy
authors.initials: SK
authors.lastname: Lam
authors.forename: Ka Keung
authors.initials: KK
authors.lastname: Lam
mesh_terms: D000743:Anemia, Hemolytic / Q000139:chemically induced* / Q000503:physiopathology; D053961:Azabicyclo Compounds / Q000506:poisoning*; D062787:Drug Overdose; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006993:Hypnotics and Sedatives / Q000506:poisoning*; D008875:Middle Aged; D018384:Oxidative Stress / Q000187:drug effects; D010879:Piperazines / Q000506:poisoning*
chemical_list: D053961:Azabicyclo Compounds; D006993:Hypnotics and Sedatives; D010879:Piperazines; C515050:zopiclone