Zn-mediated, Pd-catalyzed cross-couplings in water at room temperature without prior formation of organozinc reagents.
Mix in water, stir. That is all that is required in this new approach to sp(3)-sp(2) cross-couplings between an alkyl iodide and an aryl bromide, both potentially bearing functionality. They react under catalysis by Pd(0) in the presence of zinc powder, aided by a nonionic amphiphile, to give the alkylated aromatic. No organic solvents and no heating; just add water.
Krasovskiy
Arkady
A
Department of Chemistry & Biochemistry, University of California, Santa Barbara, California 93106, USA.
Duplais
Christophe
C
Lipshutz
Bruce H
BH