title: Giant cobblestone-like papillae during isotretinoin therapy.
abstract: OBJECTIVE
  To report a case of giant cobblestone-like papillae that appeared during oral isotretinoin therapy.
  
  
  METHODS
  Case report.
  
  
  METHODS
  A 14-year-old boy presented with bilateral eye itching for 1 week. Bilateral upper palpebral conjunctival cobblestone-like papillae, superficial punctate keratitis, and shield ulcer in the left cornea were seen. At the time, he was treated with oral isotretinoin for 6 months.
  
  
  RESULTS
  Following cessation of isotretinoin, the ulcer and SPK healed, and the papillae disappeared completely after an 8-week course.
  
  
  CONCLUSIONS
  Giant cobblestone-like papillae and corneal shield ulcer may be considered as a probable isotretinoin-induced ocular adverse event.
authors.affiliation: Department of Ophthalmology, Meir Medical Center, Kfar Saba, Israel. ermd14@gmail.com
authors.forename: Eli
authors.initials: E
authors.lastname: Rosen
authors.forename: Judith
authors.initials: J
authors.lastname: Raz
authors.forename: Fani
authors.initials: F
authors.lastname: Segev
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy; D000293:Adolescent; D003229:Conjunctival Diseases / Q000139:chemically induced* / Q000473:pathology*; D003320:Corneal Ulcer / Q000139:chemically induced; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D004334:Drug Administration Schedule; D005123:Eye / Q000098:blood supply; D005141:Eyelid Diseases / Q000139:chemically induced* / Q000473:pathology*; D006801:Humans; D006940:Hyperemia / Q000139:chemically induced; D007249:Inflammation / Q000139:chemically induced / Q000473:pathology; D015474:Isotretinoin / Q000008:administration & dosage / Q000009:adverse effects*; D007634:Keratitis / Q000139:chemically induced; D008297:Male; D008537:Meibomian Glands / Q000473:pathology
chemical_list: D003879:Dermatologic Agents; D015474:Isotretinoin