Spatial variation of Yersinia pestis from Yunnan Province of China.
Yunnan Province of China is considered the site of origin for modern plague. We analyzed the genotypes of eight Yersinia pestis strains isolated from three counties in Yunnan Province by pulse field gel electrophoresis (PFGE). PFGE showed that strains isolated from the same site were identical regardless of hosts or year of isolation. However, Y. pestis strains isolated from geographically distinct loci were genetically divergent. Whole genome sequences of two strains from two foci in Yunnan showed that the genetic variation of Y. pestis strains was caused by genome rearrangement. We concluded that Y. pestis strains in each epidemic focus in Yunnan were a clonal population and selected by host environments. The genomic variability of the Y. pestis strains from different foci were caused by genome rearrangement, which may provide a positive selective advantage for Y. pestis to adapt to its host environments.
Zhang
Zhikai
Z
State Key Laboratory for Infectious Disease Prevention and Control, Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Hai
Rong
R
Song
Zhizhong
Z
Xia
Lianxu
L
Liang
Yun
Y
Cai
Hong
H
Liang
Ying
Y
Shen
Xiaona
X
Zhang
Enmin
E
Xu
Jianguo
J
Yu
Dongzheng
D
Yu
Xue-Jie
XJ
D002681:China / Q000453:epidemiology; D002874:Chromosome Mapping; D004196:Disease Outbreaks; D005798:Genes, Bacterial; D005819:Genetic Markers; D014644:Genetic Variation; D016680:Genome, Bacterial; D006801:Humans; D010930:Plague / Q000453:epidemiology / Q000382:microbiology; D015010:Yersinia pestis / Q000235:genetics*
D005819:Genetic Markers