title: VO2@RER1.0: a novel submaximal cardiopulmonary exercise index.
abstract: Maximal oxygen consumption (VO2max) is the "gold standard" by which to assess functional capacity; however, it is effort dependent. VO2@RER1.0 is defined when VO2 = VCO2. Between December 22, 1997 and November 9, 2004, 305 pediatric subjects underwent cycle ergometer cardiopulmonary exercise testing, exercised to exhaustion, and reached a peak respiratory exchange ratio > or = 1.10. Group 1 subjects achieved a peak VO2 > or = 80% of predicted VO2max; group 2 subjects achieved a peak VO2 < or = 60% of predicted VO2max; and group 3 subjects achieved a peak VO2 between 61 and 79% of predicted VO2max. Linear regression analysis was performed for VO2@RER1.0 as a function of predicted VO2 for group 1 subjects. A -2 SD regression line and equation was created. VO2@RER1.0 data from groups 2 and 3 were plotted onto the normative graph. Contingency table and relative-risk analysis showed that an abnormal VO2@RER1.0 predicted an abnormal peak VO2(positive-predictive value 83%, negative-predictive value 85%, sensitivity 84%, and specificity 84%). VO2@RER1.0 is a highly sensitive, specific, and predictive submaximal index of functional capacity. This submaximal index is easy to identify without subjectivity. This index may aid in the evaluation of subjects who cannot exercise to maximal parameters.
authors.affiliation: Division of Pediatric Cardiology, Stanford University, Palo Alto, CA 94304, USA. clifford@leland.stanford.edu
authors.forename: Clifford
authors.initials: C
authors.lastname: Chin
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Kazmucha
authors.forename: Nancy
authors.initials: N
authors.lastname: Kim
authors.forename: Reny
authors.initials: R
authors.lastname: Suryani
authors.forename: Inger
authors.initials: I
authors.lastname: Olson
mesh_terms: D000293:Adolescent; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000503:physiopathology; D002648:Child; D005080:Exercise Test / Q000379:methods*; D017079:Exercise Tolerance; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D015588:Observer Variation; D010101:Oxygen Consumption; D012131:Respiratory Insufficiency / Q000175:diagnosis / Q000503:physiopathology; D012189:Retrospective Studies; D012680:Sensitivity and Specificity