title: The value of surgery for retroperitoneal sarcoma.
abstract: Introduction. Retroperitoneal sarcomas are uncommon large malignant tumors. Methods. Forty-one consecutive patients with localized retroperitoneal sarcoma were retrospectively studied. Results. Median age was 58 years (range 20-91 years). Median tumor size was 17.5 cm (range 4-41 cm). Only 2 tumors were <5 cm. Most were liposarcoma (44%) and high-grade (59%). 59% were stage 3 and the rest was stage 1. Median followup was 10 months (range 1-106 months). Thirty-eight patients had an initial complete resection; 15 (37%) developed recurrent sarcoma and 12 (80%) had a second complete resection. Patients with an initial complete resection had a 5-year survival of 46%. For all patients, tumor grade affected overall survival (P = .006). Complete surgical resection improved overall survival for high-grade tumors (P = .03). Conclusions. Tumor grade/stage and complete surgical resection for high-grade tumors are important prognostic variables. Radiation therapy or chemotherapy had no significant impact on overall or recurrence-free survival. Complete surgical resection is the treatment of choice for patients with initial and locally recurrent retroperitoneal sarcoma.
authors.affiliation: Stanford University School of Medicine, Stanford, CA 94305, USA.
authors.forename: Sepideh
authors.initials: S
authors.lastname: Gholami
authors.forename: Charlotte D
authors.initials: CD
authors.lastname: Jacobs
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Kapp
authors.forename: Layla M
authors.initials: LM
authors.lastname: Parast
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Norton