Effect of high fat loading in Dahl salt-sensitive rats.
Salt sensitivity of blood pressure (BP) is speculated to be a characteristic in obesity-induced hypertension. To elucidate the influence of obesity on salt-sensitive hypertension, we examined the effect of fat loading on BP, renal damage, and their progression induced by salt excess in Dahl salt-sensitive (S) rats. High fat (HF: 45% fat diet: 8 weeks) diet increased BP with greater weight gain and visceral fat accumulation than low fat (10% fat) diet. In HF-fed rats, plasma glucose, plasma insulin, and urinary catecholamine increased, and urinary protein tended to be elevated. Moreover, excessive salt (8% salt diet: 8 weeks)-induced hypertension and proteinuria was accelerated in HF-fed rats. Therefore, fat loading increased BP in Dahl S rats possibly through insulin-resistance and sympathetic excitation. Moreover, fat loading accelerated salt-induced BP elevation and renal damage, suggesting excessive intake of both fat and salt, such as a civilized diet, exert the synergic harmful effects.
Nagae
Ai
A
Department of Nephrology and Endocrinology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
Fujita
Megumi
M
Kawarazaki
Hiroo
H
Matsui
Hiromitu
H
Ando
Katsuyuki
K
Fujita
Toshiro
T
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D002395:Catecholamines / Q000652:urine; D004041:Dietary Fats / Q000494:pharmacology*; D004195:Disease Models, Animal; D018450:Disease Progression; D006973:Hypertension / Q000209:etiology / Q000503:physiopathology*; D007328:Insulin / Q000097:blood; D050152:Intra-Abdominal Fat / Q000187:drug effects / Q000503:physiopathology; D007668:Kidney / Q000187:drug effects* / Q000503:physiopathology; D008297:Male; D009765:Obesity / Q000150:complications / Q000503:physiopathology*; D051381:Rats; D020303:Rats, Inbred Dahl; D017673:Sodium Chloride, Dietary / Q000494:pharmacology; D015430:Weight Gain / Q000187:drug effects / Q000502:physiology
D001786:Blood Glucose; D002395:Catecholamines; D004041:Dietary Fats; D007328:Insulin; D017673:Sodium Chloride, Dietary