title: Dexmedetomidine/ketamine for diagnostic cardiac catheterization in a child with idiopathic pulmonary hypertension.
abstract: The use of a combination of dexmedetomidine and ketamine to provide procedural sedation in a 12-year old boy with a diagnosis of idopathic pulmonary hypertension and a behavioral disorder, undergoing diagnostic cardiac catheterization, is presented. Following a loading dose of ketamine one mg/kg and dexmedetomidine one mcg/kg, an infusion of dexmedetomidine at one mcg/kg/hr was used with the patient breathing spontaneously. Stable hemodynamics were observed throughout the procedure and pulmonary vascular resistance was measured under three conditions. The dexmedetomidine infusion was continued for two hours post-catheterization, facilitating a smooth emergence.
authors.affiliation: The Congenital Heart Institute, Arnold Palmer Hospital for Children, Orlando, FL 32806, USA. hamish.munro@orhs.org
authors.forename: Hamish M
authors.initials: HM
authors.lastname: Munro
authors.forename: Donald E
authors.initials: DE
authors.lastname: Felix
authors.forename: David G
authors.initials: DG
authors.lastname: Nykanen
mesh_terms: D000778:Anesthetics, Dissociative / Q000627:therapeutic use; D006328:Cardiac Catheterization / Q000379:methods*; D002648:Child; D020927:Dexmedetomidine / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006976:Hypertension, Pulmonary / Q000175:diagnosis; D006993:Hypnotics and Sedatives / Q000627:therapeutic use; D007649:Ketamine / Q000627:therapeutic use*; D008297:Male; D014655:Vascular Resistance / Q000187:drug effects
chemical_list: D000778:Anesthetics, Dissociative; D006993:Hypnotics and Sedatives; D020927:Dexmedetomidine; D007649:Ketamine