title: Pathologic evaluation of malignant pleural mesothelioma.
abstract: Pathologists play an important role in the surgical management of diffuse malignant pleural mesothelioma, which relies heavily on accurate diagnosis and staging. The pathologist provides crucial input to the determination of many prognostic factors including histologic subtype, extent of local disease progression, resection margins, and nodal status. They consult with the clinical care team at multiple points along the treatment spectrum, preoperatively, intraoperatively, and postoperatively. Finally, they are increasingly called on to guide selection of chemotherapy and measure treatment response.
authors.affiliation: Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. lchirieac@partners.org
authors.forename: Lucian R
authors.initials: LR
authors.lastname: Chirieac
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Corson
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D003299:Cooperative Behavior; D015972:Gene Expression Regulation, Neoplastic; D005821:Genetic Techniques; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D008654:Mesothelioma / Q000235:genetics / Q000473:pathology* / Q000556:secondary / Q000601:surgery / Q000648:ultrastructure; D008854:Microscopy, Electron; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D010348:Patient Care Team; D018579:Patient Selection; D010997:Pleural Neoplasms / Q000235:genetics / Q000473:pathology* / Q000556:secondary / Q000601:surgery / Q000648:ultrastructure; D011237:Predictive Value of Tests; D019616:Thoracic Surgical Procedures; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents