The linkage of chromatin remodeling to genome maintenance: contribution from a human disease gene BRIT1/MCPH1.
Genomic DNA is packed into a highly condensed chromatin structure, which acts as natural barrier preventing accessibility of DNA. In various processes to maintain genomic integrity such as DNA replication, DNA repair, telomere regulation, proteins need to overcome the barrier of condensed chromatin to gain access to DNA. ATP-dependent chromatin remodeling is one of the fundamental mechanisms used by cells to relax chromatin. However, the chromatin remodeling complex does not contain intrinsic specificity for particular nuclear process, and the mechanism mediating its recruitment to DNA lesions remains to be an outstanding question. To address this question, in this review, we will discuss our current findings and future perspectives about how BRIT1/MCPH1, a human disease gene, specifies the function of chromatin remodelers and links chromatin remodeling to genome maintenance.
Peng
Guang
G
Department of Systems Biology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
Lin
Shiaw-Yih
SY
D000818:Animals; D018797:Cell Cycle Proteins; D042002:Chromatin Assembly and Disassembly; D003598:Cytoskeletal Proteins; D004247:DNA / Q000235:genetics / Q000378:metabolism; D004260:DNA Repair; D008040:Genetic Linkage; D015894:Genome, Human; D006801:Humans; D009419:Nerve Tissue Proteins / Q000235:genetics*
D018797:Cell Cycle Proteins; D003598:Cytoskeletal Proteins; C460645:MCPH1 protein, human; D009419:Nerve Tissue Proteins; D004247:DNA