title: Polymorphisms in the CASPASE genes and survival in patients with early-stage non-small-cell lung cancer.
abstract: OBJECTIVE
  This study was conducted to determine the impact of potentially functional polymorphisms in the CASPASE (CASP) genes on the survival of early-stage non-small-cell lung cancer (NSCLC) patients.
  
  
  METHODS
  Four hundred eleven consecutive patients with surgically resected NSCLC were enrolled. Nine potentially functional polymorphisms in the CASP3, CASP7, CASP8, CASP9, and CASP10 genes were investigated. The genotype and haplotype associations with overall survival (OS) and disease-free survival (DFS) were analyzed.
  
  
  RESULTS
  Patients with the rs2227310 GG genotype had a significantly decreased OS and DFS compared with patients with the CC + CG genotype (adjusted hazard ratio [aHR] for OS, 1.67; 95% CI, 1.19 to 2.35; P = .003; aHR for DFS, 1.62; 95% CI, 1.19 to 2.22; P = .002). The rs4645981C>T genotype also had a significant effect on OS and DFS (under a recessive model; aHR for OS, 2.00; 95% CI, 1.04 to 3.85; P = .04; aHR for DFS, 2.76; 95% CI, 1.58 to 4.80; P = .0003). When the rs2227310 and rs4645981 genotypes were combined, patients with one or two bad genotypes had worse OS and DFS compared with those who had zero bad genotypes (aHR for OS, 1.75; 95% CI, 1.25 to 2.45; P = .001; aHR for DFS, 1.66; 95% CI, 1.23 to 2.26; P = .001).
  
  
  CONCLUSIONS
  The CASP7 rs2227310 and CASP9 rs4645981 polymorphisms may affect survival in early-stage NSCLC. The analysis of these polymorphisms can help identify patients at high risk for a poor disease outcome.
authors.affiliation: Department of Internal Medicine, Kyungpook National University Hospital, Daegu, Republic of Korea.
authors.forename: Seung Soo
authors.initials: SS
authors.lastname: Yoo
authors.forename: Jin Eun
authors.initials: JE
authors.lastname: Choi
authors.forename: Won-Kee
authors.initials: WK
authors.lastname: Lee
authors.forename: Yi-Young
authors.initials: YY
authors.lastname: Choi
authors.forename: Sin
authors.initials: S
authors.lastname: Kam
authors.forename: Min Jung
authors.initials: MJ
authors.lastname: Kim
authors.forename: Hyo-Sung
authors.initials: HS
authors.lastname: Jeon
authors.forename: Eung-Bae
authors.initials: EB
authors.lastname: Lee
authors.forename: Dong Sun
authors.initials: DS
authors.lastname: Kim
authors.forename: Myung-Hoon
authors.initials: MH
authors.lastname: Lee
authors.forename: In-San
authors.initials: IS
authors.lastname: Kim
authors.forename: Sanghoon
authors.initials: S
authors.lastname: Jheon
authors.forename: Jae Yong
authors.initials: JY
authors.lastname: Park
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics* / Q000401:mortality; D020169:Caspases / Q000235:genetics*; D018572:Disease-Free Survival; D005260:Female; D005838:Genotype; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011379:Prognosis; D016019:Survival Analysis; D015996:Survival Rate
chemical_list: D020169:Caspases