Survival analysis of patients with duodenal gastrointestinal stromal tumors.
OBJECTIVE
To evaluate the survival characteristics of patients with duodenal gastrointestinal stromal tumors (GISTs).


BACKGROUND
GISTs represent the most common mesenchymal neoplasms. However, duodenal GISTs are relatively rare, and few studies have been performed with a focus on duodenal GISTs.


METHODS
We collected the data of 41 GIST patients including 7 duodenal cases. Clinicopathologic findings and recurrence-free survival (RFS) of duodenal GIST patients were analyzed.


RESULTS
The proportion of having any symptoms was 86% in duodenum, 32% in stomach, and 56% in other GISTs (P=0.034), and the most common symptoms of duodenal GISTs were melena and anemia. The 2-year RFS rates were 51.4% in duodenal GISTs, 78.4% in stomach GISTs, and 100% in other GISTs, and duodenal GISTs showed poorer RFS than nonduodenal GISTs (hazard ratio, 5.1; log-rank P=0.019). Particularly, in low-risk and intermediate-risk group, the hazard ratio of recurrence was 12.3 (log-rank P=0.010). Multivariate Cox analysis showed symptom (P=0.007), mitotic index (P=0.011), and tumor location (P=0.043) were significant prognostic factors of recurrence.


CONCLUSIONS
RFS of duodenal GISTs was worse than nonduodenal GISTs.
Miki
Yuichiro
Y
Department of Surgery, Osaka National Hospital, Osaka, Japan.
Kurokawa
Yukinori
Y
Hirao
Motohiro
M
Fujitani
Kazumasa
K
Iwasa
Yoko
Y
Mano
Masayuki
M
Nakamori
Shoji
S
Tsujinaka
Toshimasa
T
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018572:Disease-Free Survival; D004379:Duodenal Neoplasms / Q000401:mortality* / Q000473:pathology; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000401:mortality* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D008940:Mitotic Index; D015999:Multivariate Analysis; D009364:Neoplasm Recurrence, Local; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012307:Risk Factors; D016019:Survival Analysis