title: Variations in serum transforming growth factor-beta1 levels with gender, age and lifestyle factors of healthy Japanese adults.
abstract: Elevated serum or plasma Transforming Growth Factor-beta1 (TGF-beta1) {levels have been} linked to cancer and other diseases in numerous studies; however, very few studies have reported an association between circulating TGF-beta1 and lifestyle factors in healthy people. We examined the association between serum TGF-beta1 levels and gender, age, body mass index (BMI), smoking, and drinking in a large population-based cohort study (N =9,142). Serum TGF-beta1 levels were {detected by the Quantikine enzyme-linked immunoassay kit (R&D Systems). The data indicated highly significant (p< ;0.0001) difference in serum TGF-beta1 levels between men (mean value: 37.6 +/- 0.12 ng/mL, N=4888) and women (mean value: 35.1 +/- 0.12 ng/ml, N=4254)}. Serum TGF-beta1 levels decreased with age (trend p< 0.0001) and were positively associated with obesity (trend p< 0.0001) in both men and women. We observed a significant trend with increased serum TGF-beta1 levels corresponding to increased amount of tobacco and alcohol consumption in men (trend p< 0.0001). These findings suggest that serum TGF-beta1 levels appear to be modulated by {gender}, age and lifestyle factors such as obesity, cigarette smoking, and alcohol drinking in healthy Japanese adults.
authors.affiliation: Department of Public Health, Aichi Medical University School of Medicine, Nagakute, Japan. linys@aichi-medu.ac.jp
authors.forename: Yingsong
authors.initials: Y
authors.lastname: Lin
authors.forename: Kei
authors.initials: K
authors.lastname: Nakachi
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Ito
authors.forename: Shogo
authors.initials: S
authors.lastname: Kikuchi
authors.forename: Akiko
authors.initials: A
authors.lastname: Tamakoshi
authors.forename: Kiyoko
authors.initials: K
authors.lastname: Yagyu
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Inaba
authors.lastname: Kazuo Tajima
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000428:Alcohol Drinking; D015992:Body Mass Index; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D005838:Genotype; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008019:Life Style; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000453:epidemiology; D016133:Polymerase Chain Reaction; D011379:Prognosis; D012307:Risk Factors; D012737:Sex Factors; D012907:Smoking; D053773:Transforming Growth Factor beta1 / Q000097:blood*
chemical_list: D053773:Transforming Growth Factor beta1