title: Primary treatment of zygomycosis with liposomal amphotericin B: analysis of 28 cases.
abstract: Lipid formulations of amphotericin B are increasingly used in lieu of deoxycholate amphotericin B for primary treatment of zygomycosis, but little is known about the efficacy of the former antifungal in treating this fungal disease. We therefore undertook an analysis of a case series of all patients with zygomycosis who received L-AMB for primary antifungal therapy in five major mid-Atlantic medical centers. Among the categories of variables studied were demographics, methods of diagnosis, microbiology, sites of infection, global responses, and survival. The median patient age was 44 years and 71% were male. Immunosuppressive hematological disorders (54%) were the most common underlying condition. Pulmonary disease constituted 50% of infections, sinus infection 29%, and cutaneous disease 18%. Members of the genus Rhizopus were the most common recovered agents. Success as defined by complete or partial positive response was noted in 32% of the cases. Concomitant surgery was performed in 46% of the cases, with similar response rates (31%). Overall survival was 39%. L-AMB was effective as primary therapy in only some patients in this cohort of highly immunocompromised individuals with invasive zygomycosis underscoring the importance of host response and the need for further advances for treatment of this lethal infection.
authors.affiliation: Section of Infectious Diseases, Department of Medicine, Washington Hospital Center, Washington, DC, USA.
authors.forename: Shmuel
authors.initials: S
authors.lastname: Shoham
authors.forename: Shelley S
authors.initials: SS
authors.lastname: Magill
authors.forename: William G
authors.initials: WG
authors.lastname: Merz
authors.forename: Corina
authors.initials: C
authors.lastname: Gonzalez
authors.forename: Nita
authors.initials: N
authors.lastname: Seibel
authors.forename: Wendy L
authors.initials: WL
authors.lastname: Buchanan
authors.forename: Tena A
authors.initials: TA
authors.lastname: Knudsen
authors.forename: Tatyana A
authors.initials: TA
authors.lastname: Sarkisova
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Walsh
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000666:Amphotericin B / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D003646:Debridement / Q000706:statistics & numerical data; D005260:Female; D005658:Fungi / Q000145:classification / Q000302:isolation & purification; D006801:Humans; D016867:Immunocompromised Host; D007223:Infant; D008297:Male; D008875:Middle Aged; D016019:Survival Analysis; D016896:Treatment Outcome; D014481:United States; D055815:Young Adult; D020096:Zygomycosis / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology / Q000601:surgery
chemical_list: D000935:Antifungal Agents; C068538:liposomal amphotericin B; D000666:Amphotericin B