title: HIV-1 Tat-based vaccines: an overview and perspectives in the field of HIV/AIDS vaccine development.
abstract: The HIV epidemic continues to represent one of the major problems worldwide, particularly in the Asia and Sub-Saharan regions of the world, with social and economical devastating effects. Although antiretroviral drugs have had a dramatically beneficial impact on HIV-infected individuals that have access to treatment, it has had a negligible impact on the global epidemic. Hence, the inexorable spreading of the HIV pandemic and the increasing deaths from AIDS, especially in developing countries, underscore the urgency for an effective vaccine against HIV/AIDS. However, the generation of such a vaccine has turned out to be extremely challenging. Here we provide an overview on the rationale for the use of non-structural HIV proteins, such as the Tat protein, alone or in combination with other HIV early and late structural HIV antigens, as novel, promising preventative and therapeutic HIV/AIDS vaccine strategies.
authors.affiliation: Department of Histology, Microbiology and Medical Biotechnology, University of Padova, Padova, Italy.
authors.forename: Antonella
authors.initials: A
authors.lastname: Caputo
authors.forename: Riccardo
authors.initials: R
authors.lastname: Gavioli
authors.forename: Stefania
authors.initials: S
authors.lastname: Bellino
authors.forename: Olimpia
authors.initials: O
authors.lastname: Longo
authors.forename: Antonella
authors.initials: A
authors.lastname: Tripiciano
authors.forename: Vittorio
authors.initials: V
authors.lastname: Francavilla
authors.forename: Cecilia
authors.initials: C
authors.lastname: Sgadari
authors.forename: Giovanni
authors.initials: G
authors.lastname: Paniccia
authors.forename: Fausto
authors.initials: F
authors.lastname: Titti
authors.forename: Aurelio
authors.initials: A
authors.lastname: Cafaro
authors.forename: Flavia
authors.initials: F
authors.lastname: Ferrantelli
authors.forename: Paolo
authors.initials: P
authors.lastname: Monini
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Ensoli
authors.forename: Barbara
authors.initials: B
authors.lastname: Ensoli
mesh_terms: D016915:AIDS Vaccines / Q000276:immunology; D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy; D000818:Animals; D002986:Clinical Trials as Topic; D006801:Humans
chemical_list: D016915:AIDS Vaccines; C421254:human immunodeficiency virus type 1 Tat vaccine