Lupus-like histopathology in bloom syndrome: reexamining the clinical and histologic implications of photosensitivity.
Bloom syndrome is a rare genodermatosis of autosomal recessive inheritance. Although lupus-like skin lesions characterize this disorder, mechanisms of photosensitivity are poorly understood. In this case presentation, the authors report a patient with Bloom syndrome whose lupus-like facial rash revealed striking histopathologic similarities to cutaneous lupus erythematosus.
McGowan
Joseph
J
Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, Charleston, SC 29425, USA. mcgowanj@musc.edu
Maize
John
J
Cook
Joel
J
D000293:Adolescent; D001816:Bloom Syndrome / Q000150:complications / Q000235:genetics / Q000473:pathology*; D003937:Diagnosis, Differential; D006801:Humans; D008178:Lupus Erythematosus, Cutaneous / Q000473:pathology*; D008297:Male; D010787:Photosensitivity Disorders / Q000150:complications / Q000235:genetics / Q000473:pathology*; D012871:Skin Diseases / Q000209:etiology / Q000235:genetics / Q000473:pathology*