title: Primary cutaneous marginal zone lymphoma.
abstract: Primary cutaneous marginal zone B-cell lymphoma (PCMZL) is included in the group of extranodal marginal zone B-cell lymphoma involving mucosal sites. Many evidences suggest that chronic antigen stimulation is a key-player in its pathogenesis. While Helicobacter pylori seems not to be implicated in PCMZL, Borrelia Burgdorferi's role is still matter of debate since the results are discordant between European and North American/Asian countries. However Borrelia subspecies are different between the studied areas and this difference could be a confounding factor. Then ubiquitous candidate antigen is still missing. Beyond these discrepancies the treatment of diffuse PCMZL has been recently improved. If local therapies (surgery, radiation) are the gold standard for localized disease, rituximab can also be considered as an alternative for disseminated or plurifocal PCMZL.
authors.affiliation: Service de dermatologie, Université Claude Bernard Lyon I, Hospices Civils de Lyon, Lyon, France. stephane.dalle@chu-lyon.fr
authors.forename: Stéphane
authors.initials: S
authors.lastname: Dalle
authors.forename: Luc
authors.initials: L
authors.lastname: Thomas
authors.forename: Brigitte
authors.initials: B
authors.lastname: Balme
authors.forename: Charles
authors.initials: C
authors.lastname: Dumontet
authors.forename: Catherine
authors.initials: C
authors.lastname: Thieblemont
mesh_terms: D006801:Humans; D016130:Immunophenotyping; D008223:Lymphoma / Q000235:genetics / Q000276:immunology / Q000473:pathology* / Q000628:therapy; D011379:Prognosis; D012878:Skin Neoplasms / Q000235:genetics / Q000276:immunology / Q000473:pathology* / Q000628:therapy