Structure casts light on mtDNA replication.
In this issue, Lee et al. (2009) present a crystal structure of the human mitochondrial DNA polymerase (POLgamma). The structure of this heterotrimeric enzyme lays a foundation for understanding how POLgamma mutations cause human mitochondrial disease and why some antiviral nucleoside analogs cause cellular toxicity.
Falkenberg
Maria
M
Department of Medical Biochemistry and Cell Biology, Göteborg University, SE-405 30 Göteborg, Sweden. maria.falkenberg@medkem.gu.se
Larsson
Nils-Göran
NG
D000074002:DNA Polymerase gamma; D004261:DNA Replication; D004272:DNA, Mitochondrial / Q000378:metabolism*; D004259:DNA-Directed DNA Polymerase / Q000737:chemistry*; D006801:Humans; D008928:Mitochondria / Q000235:genetics / Q000378:metabolism
D004272:DNA, Mitochondrial; D000074002:DNA Polymerase gamma; D004259:DNA-Directed DNA Polymerase