SNAP-25: a novel candidate gene in psychiatric genetics.
SNAP-25 (synaptosomal-associated protein of 25 kDa) is an integral part of SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor), a docking complex for synaptic vesicle exocytosis and neurotransmitter release. Results with SNAP-25 deficient mouse models highly accelerated association studies of SNAP-25 as a candidate gene for psychiatric disorders, such as Attention Deficit Hyperactivity Disorder (ADHD) and Schizophrenia. Candidate gene studies implicate a large number of single nucleotide polymorphisms (SNPs). Among the numerous SNPs, the miR SNPs are novel functional variants affecting the binding of specific microRNA to their target mRNA. According to our in silico studies there are two putative miR SNPs in the 3'untranslated region (3'UTR) of the SNAP-25 gene. If the putative miR SNPs are shown to have a function in vivo their implication in further psychogenetic association studies will have a higher impact.
Kovács-Nagy
Réka
R
Institute of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary.
Hu
Jimmy
J
Rónai
Zsolt
Z
Sasvári-Székely
Mária
M
D000818:Animals; D001289:Attention Deficit Disorder with Hyperactivity / Q000235:genetics; D004195:Disease Models, Animal; D005786:Gene Expression Regulation; D020022:Genetic Predisposition to Disease; D006801:Humans; D001523:Mental Disorders / Q000235:genetics*; D051379:Mice; D035683:MicroRNAs / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D012559:Schizophrenia / Q000235:genetics; D050825:Synaptosomal-Associated Protein 25 / Q000235:genetics*
D035683:MicroRNAs; D050825:Synaptosomal-Associated Protein 25