Comparison of left ventricular ejection fraction and left ventricular global strain as determinants of infarct size in patients with acute myocardial infarction.
BACKGROUND
The aim was to compare left ventricular ejection fraction (LVEF) and left ventricular (LV) global strain by speckle tracking as predictors of final infarct size.


METHODS
LV global strain and LVEF by echocardiography were assessed in the acute phase and after revascularization in 39 patients with ST-elevation myocardial infarction treated with thrombolysis.


RESULTS
After revascularization, global strain and LVEF correlated well with infarct size measured by contrast-enhanced cardiac magnetic resonance. A cutoff value of -15.0% for global strain had a sensitivity of 90% and a specificity of 86% to identify myocardial infarcts larger than 20%. Interobserver variability, expressed by intraclass correlation coefficients, for global strain and LVEF was 0.91 and 0.72, respectively.


CONCLUSIONS
LV global strain is a more precise diagnostic predictor of large infarcts compared with LVEF and is more reproducible. Global strain measured after revascularization demonstrates advantages over LVEF in the evaluation of LV injury in patients with ST-elevation myocardial infarction.
Sjøli
Benthe
B
Department of Medicine, Sørlandet Hospital HF, Arendal, Norway.
Ørn
Stein
S
Grenne
Bjørnar
B
Vartdal
Trond
T
Smiseth
Otto A
OA
Edvardsen
Thor
T
Brunvand
Harald
H
D000704:Analysis of Variance; D003287:Contrast Media; D005260:Female; D006801:Humans; D016014:Linear Models; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D012372:ROC Curve; D015203:Reproducibility of Results; D012307:Risk Factors; D012680:Sensitivity and Specificity; D013318:Stroke Volume; D014463:Ultrasonography; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology
D003287:Contrast Media