title: Epoxyphomalin A and B, prenylated polyketides with potent cytotoxicity from the marine-derived fungus Phoma sp.
abstract: Chemical investigation of a strain of the marine-derived fungus Phoma sp. has led to the discovery of epoxyphomalin A (1) and B (2), two new prenylated polyketides with unusual structural features. Epoxyphomalin A (1) showed superior cytotoxicity at nanomolar concentrations toward 12 of a panel of 36 human tumor cell lines. In COMPARE analyses, the observed cytotoxic selectivity pattern of 1 did not correlate with those of reference anticancer agents with known mechanisms of action.
authors.affiliation: Department of Botany, University of Khartoum, Khartoum, Sudan.
authors.forename: Ietidal E
authors.initials: IE
authors.lastname: Mohamed
authors.forename: Harald
authors.initials: H
authors.lastname: Gross
authors.forename: Alexander
authors.initials: A
authors.lastname: Pontius
authors.forename: Stefan
authors.initials: S
authors.lastname: Kehraus
authors.forename: Anja
authors.initials: A
authors.lastname: Krick
authors.forename: Gerhard
authors.initials: G
authors.lastname: Kelter
authors.forename: Armin
authors.initials: A
authors.lastname: Maier
authors.forename: Heinz-Herbert
authors.initials: HH
authors.lastname: Fiebig
authors.forename: Gabriele M
authors.initials: GM
authors.lastname: König
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001203:Ascomycota / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D008386:Marine Biology; D011161:Porifera / Q000382:microbiology
chemical_list: D000970:Antineoplastic Agents; D018942:Macrolides; C545922:epoxyphomalin A; C545923:epoxyphomalin B