title: Mantle cell lymphoma-like solitary polypoid tumor of the esophagus: a case report.
abstract: BACKGROUND
  Primary mantle cell lymphoma of the esophagus is quite rare, and we report here a case of a submucosal polypoid tumor of the esophagus that was pathologically similar, but not identical, to mantle cell lymphoma.
  
  
  METHODS
  A 66-year-old man underwent surgery in our hospital for a submucosal tumor of the esophagus. Histopathologically, the submucosal tumor uniformly showed a vague, nodular pattern composed of a regular proliferation of CD3-CD10-CD20+CD79a+bcl2+ small lymphoid cells with islands of abortive CD10+Ki67+ germinal centers, without evidence of marginal zone formation or lymphoepithelial lesions. These features were consistent with mantle cell lymphoma. However, the proliferating cells weakly expressed the D-type cyclins, IgD and IgM. The tumor was diagnosed as a "mantle cell lymphoma-like tumor". Postoperative examination confirmed no tumour involvement in other organs. The patient was treated with rituximab postoperatively and has been disease free for more than 28 months after surgery.
  
  
  CONCLUSIONS
  The present case might be regarded as a "hyperplastic change of the mantle zone" without the molecular features of mantle cell lymphoma, a case that adds to the limited clinicopathological data on B-lymphoproliferative diseases of the esophagus.
authors.affiliation: Department of Surgery, National Hospital Organization Mito Medical Center, 280 Sakuranosato, Ibaraki, Japan. tamori@m.tains.tohoku.ac.jp
authors.forename: Takahiro
authors.initials: T
authors.lastname: Mori
authors.forename: Takuya
authors.initials: T
authors.lastname: Komeno
authors.forename: Haruo
authors.initials: H
authors.lastname: Ohtani