Crystal structures of all-alpha type membrane proteins.
Integral membrane proteins are involved in a wide range of essential biological functions and the determination of their three-dimensional structures plays a central role in understanding their function. This review focuses on the structures of one class of integral membrane proteins: the functionally diverse all-alpha type membrane proteins. It gives an overview of all the structures determined by X-ray crystallography, describing each system and structure in turn. It shows that the structures of all-alpha type membrane proteins have made valuable contributions to understanding structure-function relationships in membrane proteins. These range from the first insights into the function of exciting individual proteins to an in-depth knowledge of protein function from entire biological systems.
McLuskey
Karen
K
Westchem, Department of Chemistry, Glasgow Biomedical Research Centre, University of Glasgow, 120 University Place, Glasgow, G12 8TA, UK. k.mcluskey@chem.gla.ac.uk
Roszak
Aleksander W
AW
Zhu
Yanshi
Y
Isaacs
Neil W
NW
D018360:Crystallography, X-Ray / Q000379:methods*; D008565:Membrane Proteins / Q000737:chemistry* / Q000648:ultrastructure*; D011487:Protein Conformation
D008565:Membrane Proteins