Membrane biogenesis: networking at the ER with atlastin.
The peripheral endoplasmic reticulum forms a dynamic network of interconnected membrane tubules. Although some determinants of this striking architecture are known, the mechanism underlying fusion of individual tubules has remained elusive. Two studies now identify atlastin proteins as key mediators of homotypic fusion of endoplasmic reticulum membranes.
Farhan
Hesso
H
Biozentrum, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland.
Hauri
Hans-Peter
HP
D004721:Endoplasmic Reticulum / Q000737:chemistry / Q000502:physiology*; D020558:GTP Phosphohydrolases / Q000378:metabolism*; D019204:GTP-Binding Proteins; D007425:Intracellular Membranes / Q000378:metabolism*; D008565:Membrane Proteins; D008958:Models, Molecular; D013045:Species Specificity
D008565:Membrane Proteins; C440006:ATL1 protein, human; D020558:GTP Phosphohydrolases; D019204:GTP-Binding Proteins