How autophagy regulates the host cell signaling associated with the postpartum bacteria cocoon experienced as a danger signal.
Shigella, the causative agent of human bacillary dysentery, invades the host cell, rapidly breaking the phagosome and multiplying in the cytosol. Here, we summarize our recent work showing the targeting of the leftover membrane remnants to autophagy together with trapped membrane-associated signaling molecules recruited during the immediate early entry step. We suggest that this mechanism participates in the bacteria-dependent orchestration of the cell response. Moreover, we propose that this signaling node may have relevance as to how the cell interprets endomembrane damage triggered by other stimuli.
Dupont
Nicolas
N
Cellular Microbiology of Infectious Pathogens, CNRS-UMR 8161, Univ. Lille Nord de France and Institut Pasteur de Lille, Lille, France.
Lafont
Frank
F
D001343:Autophagy; D004847:Epithelial Cells / Q000166:cytology / Q000378:metabolism / Q000382:microbiology; D054884:Host-Pathogen Interactions; D006801:Humans; D008928:Mitochondria / Q000378:metabolism; D012760:Shigella / Q000502:physiology*; D015398:Signal Transduction; D054875:Ubiquitination