Cardioprotective effects of anesthetic preconditioning in rats with ischemia-reperfusion injury: propofol versus isoflurane.
OBJECTIVE
We compare the cardioprotective effects of anesthetic preconditioning by propofol and/or isoflurane in rats with ischemia-reperfusion injury.


METHODS
Male adult Wistar rats were subjected to 60 min of anterior descending coronary artery occlusion followed by 120 min of reperfusion. Before the long ischemia, anesthetics were administered twice for 10 min followed by 5 min washout. Isoflurane was inhaled at 1 MAC (0.016) in I group, whereas propofol was inhaled intravenously at 37.5 mg/(kg(h) in P group. A combination of isoflurane and propofol was administered simultaneously in I+P group.


RESULTS
In control (without anesthetic preconditioning, C group), remarkable myocardial infarction and apoptosis accompanied by an increased level of cardiac troponin T were noted 120 min after ischemia-reperfusion. As compared to those of control group, I and P groups had comparable cardioprotection. In addition, I+P group shares with I and P groups the comparable cardioprotective effects in terms of myocardial infarction and cardiac troponin T elevation.


CONCLUSIONS
A combination of isoflurane and propofol produced no additional cardioprotection.
Tao
Xing
X
Department of Anesthesiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100069, China.
Lu
Ling-qiao
LQ
Xu
Qing
Q
Li
Shu-ren
SR
Lin
Mao-tsun
MT
D018685:Anesthetics, Inhalation / Q000008:administration & dosage; D018686:Anesthetics, Intravenous / Q000008:administration & dosage; D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D002316:Cardiotonic Agents / Q000008:administration & dosage*; D004347:Drug Interactions; D006439:Hemodynamics; D019157:Ischemic Preconditioning, Myocardial / Q000379:methods*; D007530:Isoflurane / Q000008:administration & dosage*; D008297:Male; D009203:Myocardial Infarction / Q000097:blood / Q000473:pathology / Q000517:prevention & control; D015742:Propofol / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar; D020107:Troponin T / Q000097:blood
D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D002316:Cardiotonic Agents; D020107:Troponin T; D007530:Isoflurane; D015742:Propofol