Medical and surgical perspectives of cardiac hypertrophy in Costello syndrome.
We describe our experience with 2 patients having Costello syndrome, aged 11 and 36 months, who suffered systolic anterior motion of the aortic leaflet of the mitral valve and obstructive cardiac hypertrophy requiring surgery, comparing their cardiac characteristics to those described previously. We conclude that the heterogeneous nature of the cardiac hypertrophy in this syndrome can be considered and managed as the sum of a diffuse hypertrophy accessible to beta-blockade, and an asymmetric hypertrophy accessible to surgical myomectomy.
Kalfa
David
D
Department of Thoracic and Cardio-Vascular Surgery, La Timone Children's Hospital, CHU Marseille, 264 rue Saint-Pierre, Marseille, France. davidkalfa@gmail.com
Fraisse
Alain
A
Kreitmann
Bernard
B
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D006348:Cardiac Surgical Procedures; D006332:Cardiomegaly / Q000188:drug therapy* / Q000209:etiology / Q000601:surgery*; D002675:Child, Preschool; D056685:Costello Syndrome / Q000150:complications*; D005260:Female; D006801:Humans; D007223:Infant
D000319:Adrenergic beta-Antagonists