Acute illness induces the release of aversive odor cues from adult, but not prepubertal, male rats and suppresses social investigation by conspecifics.
The present study examined odorant communication during acute illness provoked by injection of lipopolysaccharide (LPS; 100 microg/kg) and how these effects vary between prepubertal and adult conspecifics. Exposure to odor of LPS-treated adult male rats produced increased avoidance in both sexes of adults and prepubertal male partners. This response was not found when they were exposed to odor of LPS-treated prepubertal males. Even a 2.5-fold higher load of LPS in prepubertal males failed to produce aversive odor cues, suggesting that the difference in the odor is not a simple issue of dose/body volume. Both estradiol benzoate (20 microg/kg) and testosterone propionate (500 microg/kg), but not dihydrotestosterone (500 microg/kg) pretreatment in prepubertal males administered LPS restored the expression of aversive odor. These hormone treatments per se did not influence odor properties of prepubertal males, indicating that estrogen receptors may play a key regulatory role in the expression of aversive odor in LPS-treated prepubertal rats. These data suggest that the expression of sickness-related odor emerges through puberty, and likely involves a complex interaction between inflammation and sex steroids across development.
Arakawa
Hiroyuki
H
Behavioral Neuroscience Program, Department of Psychology, State University of New York at Binghamton, Binghamton, New York 13902-6000, USA. harakawa@binghamton.edu
Arakawa
Keiko
K
Deak
Terrence
T
D000210:Acute-Phase Reaction / Q000503:physiopathology*; D000367:Age Factors; D000704:Analysis of Variance; D000728:Androgens / Q000494:pharmacology; D000819:Animal Communication; D000818:Animals; D013196:Dihydrotestosterone / Q000494:pharmacology; D004958:Estradiol / Q000031:analogs & derivatives / Q000494:pharmacology; D004967:Estrogens / Q000494:pharmacology; D005260:Female; D007274:Injections, Intraperitoneal; D008070:Lipopolysaccharides / Q000633:toxicity; D008297:Male; D009812:Odorants; D055696:Olfactory Perception / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012737:Sex Factors; D012903:Smell / Q000502:physiology; D012919:Social Behavior; D043343:Testosterone Propionate / Q000494:pharmacology
D000728:Androgens; D004967:Estrogens; D008070:Lipopolysaccharides; D013196:Dihydrotestosterone; C074283:estradiol 3-benzoate; D004958:Estradiol; D043343:Testosterone Propionate