Brain perfusion SPECT correlates with CSF biomarkers in Alzheimer's disease.
OBJECTIVE
Our aim was to study the correlations between cerebrospinal fluid (CSF) biomarker levels such as beta-amyloid 42 (Abeta(42)), total and phosphorylated tau protein (T-tau and P-tau) and brain perfusion SPECT in Alzheimer's disease (AD) using a voxel-based methodology.


METHODS
Patients (n = 31) with clinical features of AD (n = 25) or amnestic mild cognitive impairment (aMCI) (n = 6) were retrospectively included. All subjects underwent the same clinical, neuropsychological and neuroimaging tests. They had a lumbar puncture and a brain perfusion ((99m)Tc-ECD) SPECT within a time interval of 10 (+/-26) days. Correlations between CSF biomarker concentrations and perfusion were studied using SPM2 software. Individual normalised regional activity values were extracted from the eligible clusters for calculation of correlation coefficients.


RESULTS
No significant correlation was found between Abeta(42) concentrations and brain perfusion. A significant correlation (p < 0.01, corrected) was found between T-tau or P-tau concentrations and perfusion in the left parietal cortex.


CONCLUSIONS
Our results suggest a strong correlation between T-tau and P-tau levels and decreased brain perfusion in regions typically affected by neuropathological changes in AD.
Habert
Marie-Odile
MO
Université Pierre et Marie Curie-Paris 6, INSERM, UMR-S 678, 75013, Paris, France. habert@imed.jussieu.fr
de Souza
Leonardo Cruz
LC
Lamari
Foudil
F
Daragon
Nelle
N
Desarnaud
Serge
S
Jardel
Claude
C
Dubois
Bruno
B
Sarazin
Marie
M
D000368:Aged; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid* / Q000000981:diagnostic imaging*; D015415:Biomarkers / Q000134:cerebrospinal fluid; D001921:Brain / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D055420:Perfusion Imaging; D012984:Software; D015899:Tomography, Emission-Computed, Single-Photon
D015415:Biomarkers