title: Destroyed documents: uncovering the science that Imperial Tobacco Canada sought to conceal.
abstract: BACKGROUND
  In 1992, British American Tobacco had its Canadian affiliate, Imperial Tobacco Canada, destroy internal research documents that could expose the company to liability or embarrassment. Sixty of these destroyed documents were subsequently uncovered in British American Tobacco's files.
  
  
  METHODS
  Legal counsel for Imperial Tobacco Canada provided a list of 60 destroyed documents to British American Tobacco. Information in this list was used to search for copies of the documents in British American Tobacco files released through court disclosure. We reviewed and summarized this information.
  
  
  RESULTS
  Imperial Tobacco destroyed documents that included evidence from scientific reviews prepared by British American Tobacco's researchers, as well as 47 original research studies, 35 of which examined the biological activity and carcinogenicity of tobacco smoke. The documents also describe British American Tobacco research on cigarette modifications and toxic emissions, including the ways in which consumers adapted their smoking behaviour in response to these modifications. The documents also depict a comprehensive research program on the pharmacology of nicotine and the central role of nicotine in smoking behaviour. British American Tobacco scientists noted that ".. the present scale of the tobacco industry is largely dependent on the intensity and nature of the pharmacological action of nicotine," and that "... should nicotine become less attractive to smokers, the future of the tobacco industry would become less secure."
  
  
  CONCLUSIONS
  The scientific evidence contained in the documents destroyed by Imperial Tobacco demonstrates that British American Tobacco had collected evidence that cigarette smoke was carcinogenic and addictive. The evidence that Imperial Tobacco sought to destroy had important implications for government regulation of tobacco.
authors.affiliation: Department of Health Studies & Gerontology, University of Waterloo, Waterloo, Ontario. dhammond@uwaterloo.ca
authors.forename: David
authors.initials: D
authors.lastname: Hammond
authors.forename: Michael
authors.initials: M
authors.lastname: Chaiton
authors.forename: Alex
authors.initials: A
authors.lastname: Lee
authors.forename: Neil
authors.initials: N
authors.lastname: Collishaw
mesh_terms: D022126:Access to Information; D002170:Canada; D002273:Carcinogens; D016265:Conflict of Interest; D003257:Consumer Product Safety / Q000331:legislation & jurisprudence*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000453:epidemiology / Q000209:etiology*; D008297:Male; D009538:Nicotine / Q000009:adverse effects*; D015871:Scientific Misconduct; D012907:Smoking / Q000009:adverse effects / Q000331:legislation & jurisprudence*; D019460:Tobacco Industry / Q000331:legislation & jurisprudence*; D014342:Truth Disclosure; D006113:United Kingdom; D014481:United States
chemical_list: D002273:Carcinogens; D009538:Nicotine