The association between low levels of lead in blood and occupational noise-induced hearing loss in steel workers.
As the use of leaded gasoline has ceased in the last decade, background lead exposure has generally been reduced. The aim of this study was to examine the effect of low-level lead exposure on human hearing loss. This study was conducted in a steel plant and 412 workers were recruited from all over the plant. Personal information such as demographics and work history was obtained through a questionnaire. All subjects took part in an audiometric examination of hearing thresholds, for both ears, with air-conducted pure tones at frequencies of 500, 1000, 2000, 3000, 4000, 6000 and 8000 Hz. Subjects' blood samples were collected and analyzed for levels of manganese, copper, zinc, arsenic, cadmium and lead with inductive couple plasma-mass spectrometry. Meanwhile, noise levels in different working zones were determined using a sound level meter with A-weighting network. Only subjects with hearing loss difference of no more than 15 dB between both ears and had no congenital abnormalities were included in further data analysis. Lead was the only metal in blood found significantly correlated with hearing loss for most tested sound frequencies (p<0.05 to p<0.0001). After adjustment for age and noise level, the logistic regression model analysis indicated that elevated blood lead over 7 microg/dL was significantly associated with hearing loss at the sound frequencies of 3000 through 8000 Hz with odds ratios raging from 3.06 to 6.26 (p<0.05-p<0.005). We concluded that elevated blood lead at level below 10 microg/dL might enhance the noise-induced hearing loss. Future research needs to further explore the detailed mechanism.
Hwang
Yaw-Huei
YH
Institute of Occupational Medicine and Industrial Hygiene, College of Public Health, National Taiwan University, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan, ROC.
Chiang
Han-Yueh
HY
Yen-Jean
Mei-Chu
MC
Wang
Jung-Der
JD
D000328:Adult; D003710:Demography; D006317:Hearing Loss, Noise-Induced / Q000097:blood* / Q000139:chemically induced* / Q000453:epidemiology; D006801:Humans; D007221:Industry; D007854:Lead / Q000009:adverse effects* / Q000097:blood* / Q000378:metabolism; D013058:Mass Spectrometry; D008954:Models, Biological; D009623:Noise, Occupational / Q000009:adverse effects*; D016273:Occupational Exposure / Q000009:adverse effects / Q000032:analysis / Q000706:statistics & numerical data; D012044:Regression Analysis; D013232:Steel; D011795:Surveys and Questionnaires; D013997:Time Factors
D013232:Steel; D007854:Lead