Bilateral metachronous ovarian metastases from clear cell renal carcinoma: a case report.
BACKGROUND
Bilateral ovarian metastases from a clear cell renal carcinoma are uncommon findings and need to be differentiated from primary cancers. Diagnostic imaging and histopathological features are often inconclusive, unless they are combined.


METHODS
A 56-year-old woman with a history of right radical nephrectomy for a renal clear cell carcinoma diagnosed 10 years earlier was referred for abdominal distension and pelvic pain. Color-Doppler US and Computer Tomography scan revealed the presence of bilateral ovarian masses with regular margins, a low resistance index and poor contrast enhancement. Immunohistochemistry showed positive epithelial membrane antigen, cytokeratin, vimentin and CD10, suggesting clear cells from the previously diagnosed kidney cancer.


CONCLUSIONS
Although bilateral metachronous ovarian metastases from clear cell renal carcinoma are a very uncommon finding, they can be considered in the differential diagnosis and investigated with imaging and immunohistochemistry. The 6 cases reported in the literature indicate a good prognosis for this condition.
Albrizio
Mauro
M
Department of Radiology, Policlinico San Matteo - University of Pavia Pavia (27100) Italy. mailbox@mauroalbrizio.eu
La Fianza
Alfredo
A
Gorone
Maria Sole Prevedoni
MS