title: Oxidative stress and myeloperoxidase activity during bacterial meningitis: effects of febrile episodes and the BBB permeability.
abstract: OBJECTIVE
  To investigate participation of extracellular myeloperoxidase (MPO) in oxidative stress during different courses of the bacterial meningitis (BM).
  
  
  METHODS
  We sequentially assessed WBC count, blood-brain barrier (BBB) permeability, serum and cerebrospinal fluid (CSF) lipid peroxidation (LPO), MPO and antioxidative activity (AOA) in proven pediatric BM.
  
  
  RESULTS
  BM patients exhibited increased systemic and local LPO and MPO, and reduced AOA, which was exaggerated in the febrile episodes. Serum MPO and LPO products were related to the BBB permeability at the baseline. CSF hydroperoxide level was influenced by the BBB permeability, CSF albumin concentration, and serum hydroperoxide (r=0.502; p<0.001, and r=0.611; p<0.001, and r=0.358; p<0.001, respectively). CSF hydroperoxide and MPO correlated in complicated cases during the study.
  
  
  CONCLUSIONS
  These results suggest that CSF LPO and MPO were closely related in BM, had different courses if febrile episodes had occurred, but were partly influenced by the BBB permeability.
authors.affiliation: Institute of Biochemistry, Medical Faculty Pristina (Kosovska Mirtovica), Anri Dinana bb, 38220, Kosovska Mitrovica, Serbia. marko.miric@Gmail.com
authors.forename: Dijana
authors.initials: D
authors.lastname: Miric
authors.forename: Radoslav
authors.initials: R
authors.lastname: Katanic
authors.forename: Bojana
authors.initials: B
authors.lastname: Kisic
authors.forename: Lepsa
authors.initials: L
authors.lastname: Zoric
authors.forename: Bratislav
authors.initials: B
authors.lastname: Miric
authors.forename: Radoslav
authors.initials: R
authors.lastname: Mitic
authors.forename: Ilija
authors.initials: I
authors.lastname: Dragojevic
mesh_terms: D000975:Antioxidants / Q000378:metabolism; D001812:Blood-Brain Barrier / Q000378:metabolism*; D002199:Capillary Permeability / Q000502:physiology*; D002555:Cerebrospinal Fluid / Q000737:chemistry; D002648:Child; D002675:Child, Preschool; D005334:Fever / Q000503:physiopathology*; D006801:Humans; D007223:Infant; D015227:Lipid Peroxidation / Q000502:physiology; D008297:Male; D016920:Meningitis, Bacterial / Q000503:physiopathology*; D018384:Oxidative Stress; D009195:Peroxidase / Q000378:metabolism*; D044967:Serum / Q000737:chemistry
chemical_list: D000975:Antioxidants; D009195:Peroxidase