title: Bacterial translocation to mesenteric lymph nodes increases in chronic portal hypertensive rats.
abstract: OBJECTIVE
  Bacterial translocation is a frequent complication in portal hypertension related to cirrhosis in the human clinical area. The aim of this study was to verify the existence of intestinal bacterial translocation to mesenteric lymph nodes in male Wistar rats with triple partial portal vein ligation during short- (48 h) and long-term (1 month) postoperative evolution.
  
  
  RESULTS
  At 48 h, ileal total aerobes bacteria (p < 0.001) and Lactobacillus decrease in sham-operated (SO) and portal hypertensive (PH) rats. At 1 month, ileal Enterococci and Streptococcus sp. show a statistically significant decrease in SO- and PH-rats. Lactobacillus decreases in the colon in SO- (p < 0.01) and in PH-rats (p < 0.001). At 1 month, colonic Enterococci decreases compared to control (p < 0.001) and SO-rats (p < 0.01). These intestinal microfloral changes are associated with bacterial translocation to mesenteric lymph nodes at 48 h (50%; p = 0.004) and 1 month (100%; p < 0.001) of postoperative evolution in PH-rats.
  
  
  CONCLUSIONS
  The enlargement of the stenosed portal tract related to triple partial portal vein ligation in the rat, since it increases the resistance to the portal blood flow, may be a key factor involved in one of the pathological consequences of portal hypertension, as is bacterial translocation to mesenteric lymph nodes.
authors.affiliation: Microbiology Department, Biology School, Complutense University of Madrid, Madrid, Spain.
authors.forename: Miguel-Angel
authors.initials: MA
authors.lastname: Llamas
authors.forename: María-Angeles
authors.initials: MA
authors.lastname: Aller
authors.forename: Domingo
authors.initials: D
authors.lastname: Marquina
authors.forename: María-Paz
authors.initials: MP
authors.lastname: Nava
authors.forename: Jaime
authors.initials: J
authors.lastname: Arias
mesh_terms: D000818:Animals; D001420:Bacteria, Aerobic / Q000302:isolation & purification*; D002908:Chronic Disease; D006975:Hypertension, Portal / Q000150:complications*; D007082:Ileum / Q000382:microbiology / Q000473:pathology; D008198:Lymph Nodes / Q000382:microbiology*; D008297:Male; D008643:Mesentery; D051381:Rats