title: Discriminative conditioning with different CS-US intervals produces temporally differentiated conditioned responses in the two eyes of the rabbit (Oryctolagus cuniculus).
abstract: The conditioned eyeblink response (CR) in rabbits is lateralized to the eye targeted by the unconditioned stimulus (US). However, a contralateral component has been reported during concurrent discriminative conditioning of the two eyes. The authors investigated CRs produced by both eyes during conditioning with 2 different interstimulus intervals (ISIs) in which a short conditioned stimulus (CS) was paired with a US to the left eye and a long CS was paired with a US to the right eye. Whether the 2 CSs were more or less similar (or identical), the short CS produced short-latency CRs in the left eye, whereas the long CS produced long-latency CRs in the right eye. The contralateral responses to a CS trained at one ISI were separable into temporal corollaries of the ipsilateral response (suggesting a bilaterality of the CR) versus those to a CS trained at another ISI (indicating generalization between the CSs). The results indicate that the neuronal substrates subserving CRs of the two eyes involve not only a dominant lateralization but also some avenue of bilaterality.
authors.affiliation: Department of Psychology, Yale University, USA. taekwan.lee@gmail.com
authors.forename: Taekwan
authors.initials: T
authors.lastname: Lee
authors.forename: Jeansok J
authors.initials: JJ
authors.lastname: Kim
authors.forename: Allan R
authors.initials: AR
authors.lastname: Wagner
mesh_terms: D000161:Acoustic Stimulation; D000704:Analysis of Variance; D000818:Animals; D001307:Auditory Perception; D001767:Blinking / Q000502:physiology*; D003215:Conditioning, Eyelid / Q000502:physiology*; D004558:Electric Stimulation; D007839:Functional Laterality / Q000502:physiology*; D008297:Male; D011817:Rabbits; D013997:Time Factors