title: [Application of fluorescence in situ hybridization in prenatal diagnosis of complex chromosomal abnormalities].
abstract: OBJECTIVE
  To investigate the application of fluorescence in situ hybridization (FISH) technique in prenatal diagnosis of complex chromosomal abnormalities.
  
  
  METHODS
  Eleven prenatal diagnosis cases (8 from amniocentesis and 3 from cord blood) with complex chromosomal abnormalities detected by routine G-banding, were further analyzed by FISH.
  
  
  RESULTS
  The FISH technique confirmed the results of balanced chromosome rearrangements detected by G-banding, and clarified the structure of the derivative chromosomes in the 3 amniocentesis samples and the origin of the mark chromosomes in the 2 cord blood samples.
  
  
  CONCLUSIONS
  FISH can be used to diagnose the complex chromosomal abnormalities accurately in prenatal diagnosis, and can provide very useful genetic information for clinical diagnosis and treatment.
authors.affiliation: Xiamen Maternity and Child Health Care Hospital, Xiamen, Fujian, 361003, PR China.
authors.forename: Yan-yan
authors.initials: YY
authors.lastname: Shen
authors.forename: Jian
authors.initials: J
authors.lastname: Li
authors.forename: Hui
authors.initials: H
authors.lastname: Kong
authors.forename: Hui-nan
authors.initials: HN
authors.lastname: Wu
authors.forename: Qiong
authors.initials: Q
authors.lastname: Wu
authors.forename: Yun-sheng
authors.initials: YS
authors.lastname: Ge
authors.forename: Xin-li
authors.initials: XL
authors.lastname: Huang
authors.forename: Yu-lin
authors.initials: YL
authors.lastname: Zhou
mesh_terms: D000653:Amniotic Fluid / Q000737:chemistry; D002869:Chromosome Aberrations; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D006801:Humans; D017404:In Situ Hybridization, Fluorescence / Q000379:methods*; D011247:Pregnancy / Q000235:genetics*; D011296:Prenatal Diagnosis / Q000379:methods*