Blood relatives: dynamic regulation of bioactive lysophosphatidic acid and sphingosine-1-phosphate metabolism in the circulation.
Lysophosphatidic acid and sphingosine 1-phosphate are bioactive lipid mediators with potent effects on cardiovascular development and vascular function. New studies define dynamic mechanisms that maintain physiologically relevant levels of both lipids in the blood. We review the mechanisms controlling the production, metabolism, and distribution of these lipids between vascular cells, circulating blood components, and the plasma.
Morris
Andrew J
AJ
The Gill Heart Institute, University of Kentucky College of Medicine, Lexington, KY 40536, USA. a.j.morris@uky.edu
Selim
Samy
S
Salous
Abdel
A
Smyth
Susan S
SS
D000818:Animals; D002319:Cardiovascular System / Q000378:metabolism*; D006801:Humans; D008246:Lysophospholipids / Q000097:blood*; D051379:Mice; D023421:Models, Animal; D049349:Receptors, Lysosphingolipid / Q000378:metabolism; D015398:Signal Transduction; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000097:blood; D013997:Time Factors
D008246:Lysophospholipids; D049349:Receptors, Lysosphingolipid; C060506:sphingosine 1-phosphate; D013110:Sphingosine; C032881:lysophosphatidic acid