Lymph node tumor metastases: more susceptible than primary tumors to CD8(+) T-cell immune destruction.
Hematopoietic cells, and more particularly, dendritic cells are so called "professional" antigen-presenting cells, which prime CD8(+) T-cell responses. They achieve this by taking up antigens and presenting them to CD8(+) T cells in the draining lymph nodes. This process is called cross-presentation (XP). For most developing tumors, XP of tumor antigens results in CD8(+) T-cell tolerance. In addition to XP, direct presentation by any kind of cell can also occur in lymph nodes. We discuss here how a non-hematopoietic cell can efficiently prime CD8(+) T cells by direct presentation in lymph nodes. Such a T-cell activation pathway is likely to be of importance for the control of cancer metastases that use the lymphatic system to spread.
Contassot
Emmanuel
E
Department of Dermatology, Zürich University Hospital, Zürich, Switzerland.
Preynat-Seauve
Olivier
O
French
Lars
L
Huard
Bertrand
B
D000818:Animals; D017951:Antigen Presentation; D000951:Antigens, Neoplasm / Q000378:metabolism; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D045142:Cross-Priming; D003602:Cytotoxicity, Immunologic; D003713:Dendritic Cells / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D016219:Immunotherapy, Adoptive; D008198:Lymph Nodes / Q000276:immunology* / Q000378:metabolism* / Q000473:pathology; D008207:Lymphatic Metastasis / Q000276:immunology* / Q000517:prevention & control
D000951:Antigens, Neoplasm