title: Ultrastructural and morphological analyses of the in vitro and in vivo hemostatic effects of Ankaferd Blood Stopper.
abstract: Ultrastructural and morphological analyses of a novel hemostatic agent, Ankaferd Blood Stopper (ABS), in comparison to its in vitro and in vivo hemostatic effects were investigated. High-resolution scanning electron microscopy (SEM) images accompanied with morphological analysis after topical application of ABS revealed a very rapid (<1 second) protein network formation within concurrent vital erythroid aggregation covering the classical coagulation cascade. Histopathological examination revealed similar in vivo ABS-induced hemostatic network at the porcine hepatic tissue injury model. Instantaneous control of bleeding was achieved in human surgery-induced dental tissue injury associated with primary and secondary hemostatic abnormalities. Ankaferd Blood Stopper could hold a great premise for clinical management of surgery bleedings as well as immediate cessation of bleeding on external injuries based on upcoming clinical trials.
authors.affiliation: Department of Chemical and Environmental Engineering, University of California, Riverside, California, USA.
authors.forename: Berat Z
authors.initials: BZ
authors.lastname: Haznedaroglu
authors.forename: Ibrahim C
authors.initials: IC
authors.lastname: Haznedaroglu
authors.forename: Sharon L
authors.initials: SL
authors.lastname: Walker
authors.forename: Hasan
authors.initials: H
authors.lastname: Bilgili
authors.forename: Hakan
authors.initials: H
authors.lastname: Goker
authors.forename: Ali
authors.initials: A
authors.lastname: Kosar
authors.forename: Alper
authors.initials: A
authors.lastname: Aktas
authors.forename: Ozge
authors.initials: O
authors.lastname: Captug
authors.forename: Mevlut
authors.initials: M
authors.lastname: Kurt
authors.forename: Oktay
authors.initials: O
authors.lastname: Ozdemir
authors.forename: Serafettin
authors.initials: S
authors.lastname: Kirazli
authors.forename: Huseyin C
authors.initials: HC
authors.lastname: Firat
mesh_terms: D000818:Animals; D001773:Blood Cells / Q000187:drug effects / Q000648:ultrastructure; D006470:Hemorrhage / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D006487:Hemostasis / Q000187:drug effects*; D006490:Hemostatics / Q000494:pharmacology*; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000648:ultrastructure; D008106:Liver Cirrhosis, Experimental / Q000097:blood / Q000188:drug therapy / Q000473:pathology; D008855:Microscopy, Electron, Scanning; D023421:Models, Animal; D010936:Plant Extracts / Q000494:pharmacology*; D044967:Serum / Q000166:cytology / Q000187:drug effects; D013552:Swine
chemical_list: D006490:Hemostatics; D010936:Plant Extracts; C539751:ankaferd blood stopper