Ultrastructural and morphological analyses of the in vitro and in vivo hemostatic effects of Ankaferd Blood Stopper.
Ultrastructural and morphological analyses of a novel hemostatic agent, Ankaferd Blood Stopper (ABS), in comparison to its in vitro and in vivo hemostatic effects were investigated. High-resolution scanning electron microscopy (SEM) images accompanied with morphological analysis after topical application of ABS revealed a very rapid (<1 second) protein network formation within concurrent vital erythroid aggregation covering the classical coagulation cascade. Histopathological examination revealed similar in vivo ABS-induced hemostatic network at the porcine hepatic tissue injury model. Instantaneous control of bleeding was achieved in human surgery-induced dental tissue injury associated with primary and secondary hemostatic abnormalities. Ankaferd Blood Stopper could hold a great premise for clinical management of surgery bleedings as well as immediate cessation of bleeding on external injuries based on upcoming clinical trials.
Haznedaroglu
Berat Z
BZ
Department of Chemical and Environmental Engineering, University of California, Riverside, California, USA.
Haznedaroglu
Ibrahim C
IC
Walker
Sharon L
SL
Bilgili
Hasan
H
Goker
Hakan
H
Kosar
Ali
A
Aktas
Alper
A
Captug
Ozge
O
Kurt
Mevlut
M
Ozdemir
Oktay
O
Kirazli
Serafettin
S
Firat
Huseyin C
HC
D000818:Animals; D001773:Blood Cells / Q000187:drug effects / Q000648:ultrastructure; D006470:Hemorrhage / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D006487:Hemostasis / Q000187:drug effects*; D006490:Hemostatics / Q000494:pharmacology*; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000648:ultrastructure; D008106:Liver Cirrhosis, Experimental / Q000097:blood / Q000188:drug therapy / Q000473:pathology; D008855:Microscopy, Electron, Scanning; D023421:Models, Animal; D010936:Plant Extracts / Q000494:pharmacology*; D044967:Serum / Q000166:cytology / Q000187:drug effects; D013552:Swine
D006490:Hemostatics; D010936:Plant Extracts; C539751:ankaferd blood stopper