Circulating T-regulatory cells, exercise and the elite adolescent swimmer.
Brief high intensity exercise induces peripheral leukocytosis possibly leading to a higher incidence of allergic symptoms in athletes undergoing excessive training. We studied the exercise-induced alternation of circulating Tregs and FoxP3+ Tregs due to acute intense swim exercise in elite swimmers (n = 22, 12 males, age = 15.4 yrs). Twelve had prior or current rhinitis or asthma and 10 had no current or prior allergy or asthma. Circulating Tregs increased significantly (p < .001) following exercise (pre = 133 +/- 11.2, post = 196 +/- 17.6) as did FoxP3+ cells (pre = 44, post = 64 cells/microl). Increases in Tregs and FoxP3+ Tregs occurred to the same extent in both groups of adolescent swimmers.
Wilson
Lori D
LD
Pediatric Exercise Research Center, Department of Pediatrics, University Children's Hospital, University of California, Irvine, CA 92868, USA.
Zaldivar
Frank P
FP
Schwindt
Christina D
CD
Wang-Rodriguez
Jessica
J
Cooper
Dan M
DM
D000293:Adolescent; D001249:Asthma / Q000097:blood; D016022:Case-Control Studies; D015444:Exercise / Q000502:physiology*; D005260:Female; D051858:Forkhead Transcription Factors / Q000032:analysis; D006801:Humans; D018655:Lymphocyte Count; D008297:Male; D005082:Physical Exertion / Q000502:physiology*; D012220:Rhinitis / Q000097:blood; D013550:Swimming / Q000502:physiology*; D016176:T-Lymphocyte Subsets; D050378:T-Lymphocytes, Regulatory
C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors