[Antiatherogenic characteristics of korvitin: effect on proteasome activity of the aorta, heart, and blood cells].
We studied the changes in proteasomal proteolisis during modelling of rabbit cholesterol-induced atherosclerosis. It was determined that in aorta the TL activity of proteasome increased 2.4-fold (P < 0.05), CTL activity increased by 43%, and PGPG--by 10%. In heart tissue it was observed the increase of CTL proteasome activity by 14%. The application of "Korvitin" (water-soluble form of quercetine) followed by considerable decrease of proteasomal activity both in tissues (aorta and heart) and leucocytes. The intensity ofatherosclerotic changes in aorta was significantly smaller. Obtained data suggest that "Korvitin" reveales angioprotective properties mediated by it effect on proteasomal proteolisis.
Pashevin
D O
DO
Dosenko
B Ie
BIe
Byts'
Iu V
IuV
Moĭbenko
O O
OO
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000627:therapeutic use*; D001011:Aorta / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D050197:Atherosclerosis / Q000097:blood / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D004195:Disease Models, Animal; D005260:Female; D007962:Leukocytes / Q000378:metabolism*; D008214:Lymphocytes / Q000378:metabolism; D008297:Male; D009000:Monocytes / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D009504:Neutrophils / Q000378:metabolism; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism*; D011794:Quercetin / Q000008:administration & dosage / Q000627:therapeutic use*; D011817:Rabbits; D012995:Solubility
D000975:Antioxidants; D002791:Cholesterol, Dietary; D011794:Quercetin; D046988:Proteasome Endopeptidase Complex