title: [The role of genetic variants of the dopaminergic system in heroin dependence].
abstract: Heroin dependence is a disorder with complex inheritance. It is influenced by multiple genetic and environmental factors. This paper gives an overview on the specific risk factors in the background of heroin addiction, especially within the dopaminergic system, which is one of the most important components of the brain's reward system. In connection with the development of heroin addiction the role of the dopamine D2 and D4 receptors, the dopamine transporter and the catechol-O-methyltransferase genes is discussed. Certain polymorphisms of the most extensively studied dopamine D2 receptor gene show strong association with heroin dependence. Dopamine D4 receptor and catechol-O-methyltransferase genes are also associated with the disease, but some results are still controversial. Only few studies have been done in association with the dopamine transporter gene and substance misuse and no convincing results have been found. To unravel the contradictions and better understand the pathogenesis of the disease more research needs to be conducted.
authors.affiliation: Semmelweis Egyetem, Orvosi Vegytani, Molekuláris Biológiai es Patobiokémiai Intézet, Budapest.
authors.forename: Andrea
authors.initials: A
authors.lastname: Vereczkei
authors.forename: Mária
authors.initials: M
authors.lastname: Sasvári-Székely
authors.forename: Csaba
authors.initials: C
authors.lastname: Barta
mesh_terms: D000818:Animals; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D004298:Dopamine / Q000235:genetics* / Q000378:metabolism; D050483:Dopamine Plasma Membrane Transport Proteins / Q000235:genetics*; D006556:Heroin Dependence / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D050638:Receptors, Dopamine D4 / Q000235:genetics*
chemical_list: C493599:DRD4 protein, human; D050483:Dopamine Plasma Membrane Transport Proteins; D017448:Receptors, Dopamine D2; D050638:Receptors, Dopamine D4; D002394:Catechol O-Methyltransferase; D004298:Dopamine