Occupational exposure to non-artificial UV-light and non-melanocytic skin cancer - a systematic review concerning a new occupational disease.
BACKGROUND
Although UV exposure is the most important risk factor for cutaneous squamous cell carcinoma (SCC) and basal cell carcinoma (BCC), a systematic review analyzing the risk of occupational UV exposure is missing.


METHODS
Based on a systematic literature search in PubMed (until 05/2009) supplemented by hand search, the association between occupational UV exposure and SCC and BCC was analyzed. Literature search and data abstraction was done independently by 2 reviewers. The association between occupational UV exposure and cancer risk is presented as odds ratios (OR).


RESULTS
We identified 25 relevant epidemiologic studies (5 cohort studies, 17 case-control studies, 3 cross-sectional studies). 12 studies described a positive association between occupational UV exposure and risk of SCC with OR > 3 in 6 studies and OR 1.5-2.0 in another 6 studies. 3 studies did not find a relevant association (OR: 1.0-1.4). A significant positive association between occupational UV exposure and BCC was reported in 5 studies; 11 studies did not find a significant association.


CONCLUSIONS
The association between occupational UV exposure and SCC is well and consistently documented epidemiologically (approximately 2-fold increased risk), so that the criteria for a new occupational disease are fulfilled. The association with BCC is unclear due to significant methodological limitations in the published studies.
Schmitt
Jochen
J
Clinic and Policlinic for Dermatology, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany. jochen.schmitt@uniklinikum-dresden.de
Diepgen
Thomas
T
Bauer
Andrea
A
D005858:Germany / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology*; D009784:Occupational Diseases / Q000453:epidemiology*; D016273:Occupational Exposure / Q000706:statistics & numerical data*; D018570:Risk Assessment; D012307:Risk Factors; D012878:Skin Neoplasms / Q000453:epidemiology*; D014466:Ultraviolet Rays