Trace elements status in selenium-deficient rats--interaction with cadmium.
Although the metabolic and toxicological interactions between essential element selenium (Se) and toxic element cadmium (Cd) have been reported for a long time, the experimental studies explored mostly acute, high-dose interactions. Limited data are available regarding the effects of Se-deficiency on toxicokinetics of cadmium, as well as on the levels of key trace elements--copper, zinc, and iron. In the present study, male and female Wistar weanling rats (n = 40/41) were fed either Se-deficient or Se-adequate diet (<0.06 or 0.14 mg Se per kilogram diet, respectively) for 12 weeks, and from week 9 were drinking water containing 0 or 50 mg Cd/l as cadmium chloride. At the end of the 12-week period, trace element concentrations were estimated by AAS. Selenium-deficient rats of both genders showed significantly lower accumulation of cadmium in the liver, compared to Se-adequate rats. Zinc and iron hepatic levels were not affected by Se-deficiency. However, a significant elevation of copper was found in the liver of Se-deficient rats of both genders. Cadmium supplementation increased zinc and decreased iron hepatic level, regardless of Se status and decreased copper concentration in Se-adequate rats. Se-deficiency was also found to influence the effectiveness of cadmium mobilization in male rats.
Kotyzová
Dana
D
Department of Pharmacology and Toxicology, Faculty of Medicine in Pilsen, Charles University in Prague, Pilsen, Czech Republic.
Cerná
Pavla
P
Lesetický
Ladislav
L
Eybl
Vladislav
V
D000818:Animals; D002104:Cadmium / Q000008:administration & dosage / Q000378:metabolism* / Q000493:pharmacokinetics; D019256:Cadmium Chloride / Q000378:metabolism / Q000493:pharmacokinetics; D004032:Diet; D005260:Female; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012643:Selenium / Q000008:administration & dosage / Q000172:deficiency* / Q000378:metabolism; D013054:Spectrophotometry, Atomic; D013997:Time Factors; D014131:Trace Elements / Q000378:metabolism* / Q000493:pharmacokinetics; D014886:Weaning
D014131:Trace Elements; D002104:Cadmium; D012643:Selenium; D019256:Cadmium Chloride