[Progress of research on the expression and function of vimentin].
As a kind of cytoskeleton protein, vimentin is a major member of intermediate filament family. Vimentin is found mainly in mesenchymal cells, and its expression and phosphorylation are regulated by many factors. In the past, vimentin was revealed as a scaffold maintaining cellular integrity, and recent studies shed lights on the evidence that vimentin played many important roles in cellular adhesion, growth, apoptosis, cell signaling as well as inflammatory response. This article summarizes the recent progress of vimentin about its expression and function.
Xu
Hao Xiang
HX
Chinese Academy of Medical Science, Peking Union Medical College, Dermatology department of Peking Union Medical College Hospital, Beijing 100730, China.
Yan
Yan
Y
D017209:Apoptosis / Q000187:drug effects*; D002448:Cell Adhesion / Q000187:drug effects; D006801:Humans; D010766:Phosphorylation; D015398:Signal Transduction / Q000187:drug effects; D014746:Vimentin / Q000235:genetics* / Q000378:metabolism / Q000502:physiology*
D014746:Vimentin