[Biochemical basis of the single theory of aging. Part II. The cell aerobic status, the hypoxia resistance and proliferation].
Cells of an organism have different parameters of morphology, metabolism, isoenzyme composition, proliferation and respiration. These differences are derivatives of the cell aerobic status. The primary oxygen acceptors are the "macroscopic" cells (neurons, cardiocytes). In these obligatory aerobic cells oxygen is converted into metabolic water directly by the cytochrome oxidase activity. The secondary oxygen acceptors are the "microscopic" cells (other single-nucleus cells). In these facultative aerobic cells oxygen is converted into hydrogen peroxide. The intracellular labile peroxide pool of oxygen is formed by the oxidase, cytochrome P450, superoxide dismutase, and the mitochondrial cyan-resistance oxidase. The mitochondrial isoenzymes of catalase, glutation peroxidase, and thioredoxin reductase convert hydrogen peroxide into molecular oxygen and form high local oxygen concentration as the major factor for the cytochrome oxidase activity. The hypoxia resistance is increased by the growth of the functional activity of the peroxide-generative and peroxide-mobilizative enzyme systems.
Kirova
Iu I
IuI
Borodulin
V B
VB
D000332:Aerobiosis / Q000502:physiology; D000375:Aging / Q000502:physiology*; D000818:Animals; D015687:Cell Hypoxia / Q000502:physiology; D049109:Cell Proliferation; D002471:Cell Transformation, Neoplastic / Q000378:metabolism; D016922:Cellular Senescence / Q000502:physiology*; D006801:Humans; D008928:Mitochondria / Q000502:physiology; D008954:Models, Biological; D010101:Oxygen Consumption / Q000502:physiology