title: Toward the synthesis of the rare N-(trifluoromethyl)amides and the N-(difluoromethylene)-N-(trifluoromethyl)amines [RN(CF3)CF2R'] using BrF3.
abstract: A synthesis of a wide range of different aliphatic, aromatic, and heterocyclic N-(trifluoromethyl)amides along with aromatic N-(difluoromethylene)-N-(trifluoromethyl)amine derivatives has been developed. The starting materials are the easily available isothiocyanates, and the fluorinating reagent is the commercially available bromine trifluoride. The reaction is performed under mild conditions, and the fluorinated amides and amines are produced in moderate to high yields.
authors.affiliation: School of Chemistry, Tel-Aviv University, Tel-Aviv 69978, Israel.
authors.forename: Youlia
authors.initials: Y
authors.lastname: Hagooly
authors.forename: Julia
authors.initials: J
authors.lastname: Gatenyo
authors.forename: Aviv
authors.initials: A
authors.lastname: Hagooly
authors.forename: Shlomo
authors.initials: S
authors.lastname: Rozen
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D017605:Bromine Compounds / Q000737:chemistry*; D017611:Fluorine Compounds / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D000577:Amides; D017605:Bromine Compounds; D017611:Fluorine Compounds; C507211:bromine trifluoride