A law of mutation: power decay of small insertions and small deletions associated with human diseases.
Indels in evolutionary studies are rapidly decayed obeying a power law. The present study analyzed the length distribution of small insertions and deletions associated with human diseases and confirmed that the decay pattern of these small mutations is similar to that of indels when the mutation datasets are large enough. The describable decay pattern of somatic mutations may have application in the evaluation of varied penetrance of different mutations and in association study of gene mutation with carcinogenesis.
Zhang
Jia
J
Clinical Molecular Diagnostic Center, the Second Affiliated Hospital of Soochow University, Suzhou 215004, China.
Xiao
Li
L
Yin
Yufang
Y
Sirois
Pierre
P
Gao
Hanlin
H
Li
Kai
K
D004252:DNA Mutational Analysis; D030561:Databases, Nucleic Acid; D017353:Gene Deletion; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D006801:Humans; D057345:Sequence Inversion; D016159:Tumor Suppressor Protein p53 / Q000235:genetics
C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53