title: Individuals with first-ever clinical presentation of a lacunar infarction syndrome: Is there an increased likelihood of developing mild cognitive impairment in the first 12 months after stroke?
abstract: Patients who have suffered a single clinical lacunar syndrome, in the absence of any previous clinical stroke, have a varying neuroradiological profile. We examined general cognition in 30 nonaphasic first-ever lacunar syndrome participants, using a battery of standard clinical neuropsychological measures. At a group level, stroke participants did not demonstrate any cognitive impairment relative to well-matched community-based controls up to 12 months after stroke. There was also no evidence of increased frequencies of mild cognitive impairment after a single clinical lacunar syndrome relative to matched control participants within the first year post-stroke. The current findings represent the first investigation of the cognitive outcome of nonaphasic individuals who have a first-ever clinical lacunar syndrome. It was concluded that a clinically diagnosed first ever stroke event, presenting as a lacunar syndrome, was not associated with an elevated risk of developing mild cognitive impairment 12 months post-stroke.
authors.affiliation: Department of Psychology, The University of Melbourne, Melbourne, Australia. jfande@unimelb.edu.au
authors.forename: Jacqueline F I
authors.initials: JF
authors.lastname: Anderson
authors.forename: Michael M
authors.initials: MM
authors.lastname: Saling
authors.forename: Velandai K
authors.initials: VK
authors.lastname: Srikanth
authors.forename: Amanda G
authors.initials: AG
authors.lastname: Thrift
authors.forename: Geoffrey A
authors.initials: GA
authors.lastname: Donnan
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D020520:Brain Infarction / Q000150:complications / Q000175:diagnosis / Q000209:etiology*; D003072:Cognition Disorders / Q000150:complications / Q000209:etiology*; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D009483:Neuropsychological Tests; D012189:Retrospective Studies; D020521:Stroke / Q000150:complications*; D014057:Tomography, X-Ray Computed / Q000379:methods