title: Synthesis and antimicrobial studies of s-triazine based heterocycles.
abstract: In an effort to discover new candidates with improved antimicrobial activities we report here the synthesis and in vitro biological evalution of various series of 2-(N-methylamino)-4-(N,N-dimethylamino)-6-(arylthioureido)-s-triazine (5a-j) and (N-methylamino)-4-(N,N-dimethylamino)-6-(arylureido)-s-triazine (6a-j). All the synthesized compounds were screened in vitro for their antibacterial activity against two different gram-positive bacteria (S. aureus, B. subtilis) and two different gram-negative bacteria (P. aeruginosa, E. coli) using the broth dilution method.
authors.affiliation: Department of Chemistry, School of Sciences, Gujarat University, Ahmadabad, Gujarat, India. dharmendrah1@gmail.com
authors.forename: Dharmendra H
authors.initials: DH
authors.lastname: Patel
authors.forename: Kishor H
authors.initials: KH
authors.lastname: Chikhalia
authors.forename: Nisha K
authors.initials: NK
authors.lastname: Shah
authors.forename: Dhaval P
authors.initials: DP
authors.lastname: Patel
authors.forename: Pankaj B
authors.initials: PB
authors.lastname: Kaswala
authors.forename: Vipul M
authors.initials: VM
authors.lastname: Buha
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D013055:Spectrophotometry, Infrared; D014227:Triazines / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D006571:Heterocyclic Compounds; D014227:Triazines