title: A case of Brugada syndrome in which diurnal ECG changes were associated with circadian rhythms of sex hormones.
abstract: We describe a thought-provoking case of Brugada syndrome in which a relationship between the diurnal electrocardiogram (ECG) changes and sex hormone levels was observed. A 36-year-old man who experienced cardiac arrest was referred to our hospital. He had a family history of sudden cardiac death. The 12-lead ECG exhibited a mild coved type ST-segment elevation in leads V1 and V2, which was enhanced by intravenous pilsicainide injection. Hence, this case was diagnosed as Brugada syndrome. The circadian rhythm of the serum testosterone level revealed low levels in the daytime (1.66-1.99 ng/mL) and high levels (2.52-3.42 ng/mL) in the nighttime. Interestingly, augmentation of the ST segment elevation and widening of the P wave were observed at around 2:00 AM, when the serum testosterone was recorded at its highest. Our report discusses the influence of the circadian rhythms of sex hormones on the ECG changes in Brugada syndrome.
authors.affiliation: Department of Emergency Medicine, Asahikawa Medical College, Hokkaido, Japan.
authors.forename: Masaru
authors.initials: M
authors.lastname: Yamaki
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Sato
authors.forename: Motoi
authors.initials: M
authors.lastname: Okada
authors.forename: Satoshi
authors.initials: S
authors.lastname: Fujita
authors.forename: Kazutomo
authors.initials: K
authors.lastname: Go
authors.forename: Naka
authors.initials: N
authors.lastname: Sakamoto
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Tanabe
authors.forename: Toshiharu
authors.initials: T
authors.lastname: Takeuchi
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Kawamura
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Hasebe
mesh_terms: D000328:Adult; D053840:Brugada Syndrome / Q000503:physiopathology*; D002940:Circadian Rhythm / Q000502:physiology*; D004562:Electrocardiography; D006801:Humans; D008297:Male; D013739:Testosterone / Q000097:blood*
chemical_list: D013739:Testosterone