title: Topical capsaicin for chronic neuropathic pain in adults.
abstract: BACKGROUND
  Topical creams with capsaicin are used to treat pain from a wide range of chronic conditions including neuropathic pain. Following application to the skin capsaicin causes enhanced sensitivity to noxious stimuli, followed by a period with reduced sensitivity and, after repeated applications, persistent desensitisation. There is uncertainty about the efficacy and tolerability of capsaicin for treating painful chronic neuropathies.
  
  
  OBJECTIVE
  To review the evidence from controlled trials on the efficacy and tolerability of topically applied capsaicin in chronic neuropathic pain in adults.
  
  
  METHODS
  Cochrane CENTRAL, MEDLINE, EMBASE and Oxford Pain Relief Database, searched in May 2009.
  
  
  METHODS
  Randomised, double blind, placebo controlled studies of at least six weeks' duration, using topical capsaicin to treat neuropathic pain.
  
  
  METHODS
  Two review authors independently assessed trial quality and validity, and extracted data. Information was extracted on numbers of participants with pain relief (clinical improvement) after at least six weeks, and with local skin reactions, and used to calculate relative risk and numbers needed to treat to benefit (NNT) and harm (NNH). Details of definition of pain relief and specific adverse events were sought.
  
  
  RESULTS
  Six studies (389 participants in total) compared regular application of low dose (0.075%) capsaicin cream with placebo cream; the NNT for any pain relief over six to eight weeks was 6.6 (4.1 to 17). Two studies (709 participants in total) compared a single application of high dose (8%) capsaicin patch with placebo patch; the NNT for >/= 30% pain relief over twelve weeks was 12 (6.4 to 70). Local skin reactions were more common with capsaicin, usually tolerable, and attenuated with time; the NNH for repeated low dose application was 2.5 (2.1 to 3.1). There were insufficient data to analyse either data set by condition or outcome definition. All studies satisfied minimum criteria for quality and validity, but maintenance of blinding remains a potential problem.
  
  
  CONCLUSIONS
  Capsaicin, either as repeated application of a low dose (0.075%) cream, or a single application of a high dose (8%) patch may provide a degree of pain relief to some patients with painful neuropathic conditions. Local skin irritation, which is often mild and transient but may lead to withdrawal, is common. Systemic adverse effects are rare. Estimates of benefit and harm are not robust due to limited amounts of data for different neuropathic conditions and inconsistent outcome definition.
authors.affiliation: Pain Research and Nuffield Department of Anaesthetics, University of Oxford, West Wing (Level 6), John Radcliffe Hospital, Oxford, Oxfordshire, UK, OX3 9DU.
authors.forename: Sheena
authors.initials: S
authors.lastname: Derry
authors.forename: Rosalind
authors.initials: R
authors.lastname: Lloyd
authors.forename: R Andrew
authors.initials: RA
authors.lastname: Moore
authors.forename: Henry J
authors.initials: HJ
authors.lastname: McQuay
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000700:Analgesics / Q000008:administration & dosage* / Q000009:adverse effects; D002211:Capsaicin / Q000008:administration & dosage* / Q000009:adverse effects; D002908:Chronic Disease; D003929:Diabetic Neuropathies / Q000188:drug therapy; D015658:HIV Infections / Q000150:complications; D006801:Humans; D009437:Neuralgia / Q000188:drug therapy*; D051474:Neuralgia, Postherpetic / Q000188:drug therapy; D009824:Ointments; D010149:Postoperative Pain / Q000188:drug therapy
chemical_list: D000700:Analgesics; D009824:Ointments; D002211:Capsaicin