Increased transcutaneous oxygen tension in the skin dorsum over the foot in patients with diabetic foot disease in response to the topical use of an emulsion of hyperoxygenated Fatty acids.
The aim of this study was to examine changes in the skin over the feet of patients with diabetic foot syndrome after local application of a product containing hyperoxygenated fatty acids (HOFAs) by measuring transcutaneous oxygen. In 64 patients, transcutaneous oxygen pressure (TcPo(2)) was measured on days 0, 7, 30, 60, and 90 of the study. Foot skin dryness, shedding, and skin color were also assessed using a clinical score. The patients were grouped on the basis of initial levels of transcutaneous oxygen; group 1 comprised patients with TcPo( 2) >30 mm Hg and group 2 comprised patients with TcPo(2) <30 mm Hg on the skin over the dorsum of the feet. Increases in local oxygenation values were observed at a local level in group 2 patients after 30 days of treatment. Skin trophism showed clinical improvement in all patients and these observations may be attributed to improved local microcirculation.
Lázaro-Martínez
J L
JL
Universidad Complutense de Madrid, Madrid, Spain.
Sánchez-Ríos
J P
JP
García-Morales
E
E
Cecilia-Matilla
A
A
Segovia-Gómez
T
T
D000279:Administration, Cutaneous; D000368:Aged; D001785:Blood Gas Monitoring, Transcutaneous; D003925:Diabetic Angiopathies / Q000503:physiopathology; D017719:Diabetic Foot / Q000097:blood / Q000473:pathology / Q000628:therapy*; D004655:Emulsions; D005227:Fatty Acids / Q000008:administration & dosage*; D005260:Female; D005528:Foot; D006801:Humans; D008297:Male; D008833:Microcirculation; D010936:Plant Extracts / Q000008:administration & dosage*; D012867:Skin / Q000098:blood supply* / Q000473:pathology
D004655:Emulsions; D005227:Fatty Acids; C479536:Mepentol; D010936:Plant Extracts