title: [Thyroid dysfunction in children with chronic renal failure].
abstract: OBJECTIVE
  To determine the frequency and type of thyroid dysfunction in children with chronic renal failure (CRF) in peritoneal dialysis (PD) or hemodialysis (HD); and to establish the accuracy of the presence of goiter to identify patients with CRF and thyroid dysfunction.
  
  
  METHODS
  This is a cross-sectional study performed in a tertiary pediatric medical care center. CRF patients younger than 17 years old, with more than three months in PD or HD were included. All patients were assessed regarding their growth and sexual development; thyroid dysfunction was evaluated by serum concentration of thyrotropin (TSH), thyroxine (T4L) and triiodothyronine (T3T).
  
  
  RESULTS
  50 patients were included, 25 were male, and mean age was 12 years old. There were 14 (28%) patients with thyroid dysfunction; nine had subclinical hypothyroidism, three patients had euthyroid sick syndrome and two primary hypothyroidism. Thirteen patients had goiter: seven had thyroid dysfunction and in six patients the thyroid function was normal. The sensitivity of goiter to detect thyroid dysfunction was 50% and the specificity was 83.3%. The two patients with the greatest delay in their growth were hypothyroid.
  
  
  CONCLUSIONS
  Given that the high frequency of thyroid dysfunction in children with CRF, these patients need a systematic screening, in order to improve their quality of care.
authors.affiliation: Servicio de Endocrinologia Pediátrica, UMAE Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Institute Mexicano del Seguro Social, México DF, México.
authors.forename: E
authors.initials: E
authors.lastname: Garrido-Magaña
authors.forename: S E
authors.initials: SE
authors.lastname: Heyser-Ortiz
authors.forename: A
authors.initials: A
authors.lastname: Aguilar-Kitsu
authors.forename: L
authors.initials: L
authors.lastname: Mendoza-Guevara
authors.forename: A
authors.initials: A
authors.lastname: Ramirez-Rivera
authors.forename: E
authors.initials: E
authors.lastname: Nishimura-Meguro
authors.forename: H J
authors.initials: HJ
authors.lastname: García
authors.forename: M A
authors.initials: MA
authors.lastname: Villasís-Keever
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000453:epidemiology; D008297:Male; D013959:Thyroid Diseases / Q000150:complications*