[Genetic passport--basic contribution to active longevity and maximal life-span duration].
The review was made on gene pass conception as individual DNA data bank reflecting unique genetic peculiarities of each human, its major potential contribution in achievements of active longevity and creation most favorable conditions for maximal duration of individual life-span. Participation of major age-regulated genes such as biological clock genes and the weak chain genes in aging processes of humans is briefly outlined. The significance of genetic testing of allelic polymorphisms and marker-genes implicated in common multifactorial disorders is stressed. The problems evoked by genetic results interpretation are mentioned. Special attention is paid to Genome Wide Association Studies (GWAS) technology implemented for analysis of genetic profiles and candidate genes associated with common diseases. Scientific problems and social interests in creation of individually oriented DNA-data banks (Gene Passes) amenable for the pregnant women, children, sportsmen, etc. are discussed. The relationship of Gene Pass idea to the current international genetic program "Personificated Genome" is highlighted. Feasible perspectives for genetic testing and basic contribution of Gene Pass into gerontology practical medical service are reviewed.
Baranov
V S
VS
Baranova
E V
EV
D000375:Aging / Q000235:genetics* / Q000502:physiology; D001683:Biological Clocks / Q000235:genetics; D014644:Genetic Variation; D005826:Genetics, Medical; D015894:Genome, Human; D055106:Genome-Wide Association Study; D006801:Humans; D008136:Longevity / Q000235:genetics* / Q000502:physiology; D008957:Models, Genetic