title: Direct alkenylation and alkylation of pyridone derivatives by Ni/AlMe(3) catalysis.
abstract: Regioselective alkenylation and alkylation of 2-pyridone derivatives are achieved through inter- and intramolecular insertion of alkynes, 1,3-dienes, and alkenes into the C(6)-H bond by nickel/AlMe(3) catalysis. Coordination of the heterocycles to the Lewis acid cocatalyst through their basic carbonyl oxygen is considered to be responsible for the regioselective activation of the C-H bonds, probably through oxidative addition to nickel(0).
authors.affiliation: Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 615-8510, Japan. yoshiakinakao@npc05.mbox.media.kyoto-u.ac.jp
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Nakao
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Idei
authors.forename: Kyalo Stephen
authors.initials: KS
authors.lastname: Kanyiva
authors.forename: Tamejiro
authors.initials: T
authors.lastname: Hiyama
mesh_terms: D000475:Alkenes; D000478:Alkylation; D000480:Alkynes; D002384:Catalysis; D009532:Nickel / Q000737:chemistry; D011728:Pyridones / Q000737:chemistry*
chemical_list: D000475:Alkenes; D000480:Alkynes; D011728:Pyridones; D009532:Nickel