title: Micronutrients and lifestyles in Taiwanese patients with stage 3 to 5 chronic kidney disease.
abstract: OBJECTIVE
  Lycopene is an antioxidant that reduces oxidative stress. Analgesics are commonly used and may impair kidney function. However, the associations among plasma lycopene, analgesic use, and chronic kidney disease (CKD) are unknown. A hospital-based, case-control study was conducted to determine the association among plasma lycopene, analgesic use, and CKD.
  
  
  METHODS
  Two hundred one patients with CKD and 313 controls were recruited, and CKD was defined as an estimated glomerular filtration rate <60 mL/min per 1.73 m(2), as calculated by the Modification of Diet in Renal Disease formula. Plasma antioxidants were measured by high-performance liquid chromatography.
  
  
  RESULTS
  This study showed that the higher the plasma lycopene was, the lower the CKD risk. Specifically, in subjects with a plasma lycopene level >or=17.97 or 7.72-17.97 microg/dL, the adjusted odds ratio of CKD was 0.32 (95% confidence interval 0.18-0.58) or 0.49 (95% confidence interval 0.29-0.83), respectively, compared with subjects with a plasma lycopene level <7.72 microg/dL, independent of age, gender, level of education, paternal and maternal ethnicities, cigarette smoking, analgesic use, hypertension, and diabetes history. In contrast, the higher the plasma retinol level, the higher the risk of CKD. A significantly higher risk was demonstrated in analgesic users than in non-users (odds ratio 3.83, 95% confidence interval 1.75-8.40), but a significantly lower risk was shown in subjects who used analgesics on an as-needed basis than in non-users. Plasma lycopene tended to interact additively with analgesic consumption in modifying the CKD risk; however, the interactions were statistically insignificant.
  
  
  CONCLUSIONS
  This is the first study showing that a low plasma lycopene level is associated with CKD risk.
authors.affiliation: Department of Internal Medicine/Nephrology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.
authors.forename: Shou-Shan
authors.initials: SS
authors.lastname: Chiang
authors.forename: Cheng-Wei
authors.initials: CW
authors.lastname: Tai
authors.forename: Chi-Jung
authors.initials: CJ
authors.lastname: Chung
authors.forename: Horng-Sheng
authors.initials: HS
authors.lastname: Shiue
authors.forename: Jin-Bor
authors.initials: JB
authors.lastname: Chen
authors.forename: Chien-Tien
authors.initials: CT
authors.lastname: Su
authors.forename: Yu-Mei
authors.initials: YM
authors.lastname: Hsueh
mesh_terms: D000368:Aged; D000700:Analgesics / Q000009:adverse effects*; D000975:Antioxidants / Q000378:metabolism*; D002338:Carotenoids / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D006306:Health Surveys; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000209:etiology* / Q000517:prevention & control; D000077276:Lycopene; D008297:Male; D018977:Micronutrients / Q000097:blood*; D008875:Middle Aged; D012307:Risk Factors; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires; D013624:Taiwan; D014801:Vitamin A / Q000097:blood*
chemical_list: D000700:Analgesics; D000975:Antioxidants; D018977:Micronutrients; D014801:Vitamin A; D002338:Carotenoids; D000077276:Lycopene