title: Synthesis of tetraglucosyl- and tetrapolyamine-tetrabenzoporphyrin conjugates for an application in PDT.
abstract: This paper reports the synthesis and characterization of a new class of tetrabenzoporphyrins bearing glucosyl or polyamine units on meso positions to improve the targeting of cancer cells. Photocytotoxic activity of these photosensitizers was tested on cell lines HaCaT and MCF-7 and compared to Photofrin II.
authors.affiliation: Université de Limoges, Laboratoire de Chimie des Substances Naturelles EA 1069, Faculté des Sciences et Techniques, 123 Av. Albert Thomas, 87060 Limoges, France.
authors.forename: Florian
authors.initials: F
authors.lastname: Ménard
authors.forename: Vincent
authors.initials: V
authors.lastname: Sol
authors.forename: Cyril
authors.initials: C
authors.lastname: Ringot
authors.forename: Robert
authors.initials: R
authors.lastname: Granet
authors.forename: Sandra
authors.initials: S
authors.lastname: Alves
authors.forename: Caroline Le
authors.initials: CL
authors.lastname: Morvan
authors.forename: Yves
authors.initials: Y
authors.lastname: Queneau
authors.forename: Noboru
authors.initials: N
authors.lastname: Ono
authors.forename: Pierre
authors.initials: P
authors.lastname: Krausz
mesh_terms: D000818:Animals; D001555:Benzene Derivatives / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D001681:Biological Assay; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology; D045744:Cell Line, Tumor; D005260:Female; D005947:Glucose / Q000031:analogs & derivatives / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D008956:Models, Chemical; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use*; D011073:Polyamines / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D011166:Porphyrins / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D001555:Benzene Derivatives; D017319:Photosensitizing Agents; D011073:Polyamines; D011166:Porphyrins; D005947:Glucose