Planar cell polarity and cilia.
In the last few years, evidence has come to light suggesting that planar cell polarity signaling in vertebrates may be controlled and modulated by primary cilia, subcellular organelles that emerge from the plasma membrane of most cell types. This characteristic distinguishes vertebrate planar cell polarity signaling from that in insects. We review here some of the experimental evidence contributing to this finding. These observations have begun to suggest molecular and cellular mechanisms of the so-called ciliopathies, important human diseases characterized by defective ciliary functions.
Fischer
Evelyne
E
Institut Cochin, CNRS UMR 8104/INSERM U567, Université Paris Descartes, Paris, France.
Pontoglio
Marco
M
D000818:Animals; D002455:Cell Division; D016764:Cell Polarity; D002923:Cilia / Q000378:metabolism*; D006801:Humans; D007668:Kidney / Q000166:cytology / Q000378:metabolism; D015398:Signal Transduction