Functional roles of human kallikrein-related peptidases.
Kallikrein-related peptidases constitute a single family of 15 (chymo)trypsin-like proteases (KLK1-15) with pleiotropic physiological roles. Aberrant regulation of KLKs has been associated with diverse diseases such as hypertension, renal dysfunction, skin disorders, inflammation, neurodegeneration, and cancer. Recent studies suggested that coordinated activation and regulation of KLK activity are achieved via a complex network of interactions referred to as the "KLK activome." However, it remains to be validated whether these hypothetical KLK activation cascade pathways are operative in vivo. In addition, KLKs have emerged as versatile signaling molecules. In summary, KLKs represent attractive biomarkers for clinical applications and potential therapeutic targets for common human pathologies.
Sotiropoulou
Georgia
G
Department of Pharmacy, University of Patras, Rion, 26500 Rion-Patras, Greece. gdsotiro@upatras.gr
Pampalakis
Georgios
G
Diamandis
Eleftherios P
EP
D000818:Animals; D020022:Genetic Predisposition to Disease; D006801:Humans; D007610:Kallikreins / Q000235:genetics / Q000378:metabolism*; D053858:Metabolic Networks and Pathways / Q000502:physiology*; D008954:Models, Biological; D005810:Multigene Family; D009369:Neoplasms / Q000201:enzymology / Q000235:genetics / Q000503:physiopathology
D007610:Kallikreins