MicroRNAs and Epithelial Immunity.
MicroRNAs are required for development and maintenance of the epithelial barrier. It is hypothesized that microRNAs are involved in regulating epithelial anti-microbial defenses by targeting key epithelial effector molecules and/or influencing intracellular signaling pathways. Additionally, aberrant microRNA expression has been implicated in the pathogenesis of various diseases at the skin and mucosa. Increased understanding of the role of microRNAs in epithelial immunoregulation and identification of microRNAs of pathogenetic significance will enhance our understanding of epithelial immunobiology and immunopathology.
Liu
Jun
J
Department of Medical Microbiology and Immunology, Creighton University Medical Center, Omaha, Nebraska 68178, USA.
Drescher
Kristen M
KM
Chen
Xian-Ming
XM
D000818:Animals; D004848:Epithelium / Q000276:immunology*; D006801:Humans; D018928:Immunity, Mucosal / Q000235:genetics* / Q000276:immunology*; D035683:MicroRNAs / Q000276:immunology*
D035683:MicroRNAs