title: Effects of emissions from different type of residential heating upon cyclic guanosine monophosphate (cGMP) in blood platelets of residents.
abstract: We hypothesized that different types of residential heating would be associated with different levels of indoor carbon monoxide (CO) and further that this might result in a differential in the concentration of cyclic 3':5' guanosine monophosphate (cGMP) in blood platelets in exposed residents. Individuals, who were recruited from homes using different fuel for heating, donated a venous blood sample in the winter and in the summer. In the winter the median blood platelet cGMP value for the group using liquid propane gas (LPG) was 65% higher than for the group using piped natural gas for heating (p <0.001). Also in the group using LPG, the median concentration of cGMP in the winter was 39% higher than the summer median (p < 0.003). The mean indoor concentrations of CO were measured over a period of 1 week during the winter and were <1 ppm. We conclude that observed differences were associated with emissions from different types of heating but that CO exposure alone is too low to explain these.
authors.affiliation: Department of Primary Care and Public Health, Cardiff University, Heath Park, Cardiff, UK. Matthewsip@cardiff.ac.uk
authors.forename: I P
authors.initials: IP
authors.lastname: Matthews
authors.forename: K A
authors.initials: KA
authors.lastname: Henderson
authors.forename: C
authors.initials: C
authors.lastname: Gregory
authors.forename: S R
authors.initials: SR
authors.lastname: Palmer
authors.forename: D
authors.initials: D
authors.lastname: Lang
mesh_terms: D000368:Aged; D016902:Air Pollution, Indoor / Q000032:analysis*; D001792:Blood Platelets / Q000737:chemistry*; D002248:Carbon Monoxide / Q000032:analysis; D006152:Cyclic GMP / Q000032:analysis*; D005579:Fossil Fuels; D006361:Heating; D006801:Humans; D008875:Middle Aged; D011407:Propane; D012621:Seasons
chemical_list: D005579:Fossil Fuels; D002248:Carbon Monoxide; D006152:Cyclic GMP; D011407:Propane