The effect of ballistic thumb contractions on the excitability of the ipsilateral motor cortex.
We investigated how ballistic contractions of the left thumb affect the excitability of the ipsilateral motor cortex using transcranial magnetic stimulation (TMS). TMS was applied at the motor hotspot for the right abductor pollicis brevis (APB) muscle. In 'self-triggered' trials, participants made targeted, isometric, contractions of the left APB. The right APB was either relaxed or maintained a tonic contraction. TMS was administered as soon as possible after electromyographic onset in the left APB. In 'control' trials, the left thumb remained quiescent and TMS was triggered by the computer. In each condition, 20-24 trials were conducted. Half these trials involved a single test stimulus, TS (130% APB resting motor threshold, RMT). In the other trials, short-interval intracortical inhibition (SICI) was investigated by applying a conditioning stimulus (70% APB RMT) 3 ms prior to the TS. SICI ratios were not significantly different in self-triggered and control trials. However, when the right APB was active, significantly shorter silent periods (SPs) were observed in self-triggered trials when compared with control trials. Our results support the view that SICI and SP are mediated by different inhibitory circuits, and that ipsilateral GABA(B)-ergic circuits (assessed by SP), but not GABA(A)-ergic circuits (assessed by SICI), are affected in the period immediately following voluntary ballistic contractions.
Hinder
Mark R
MR
Motor Control Laboratory, School of Psychology, University of Tasmania, Private Bag 30, Hobart, TAS, 7001, Australia. Mark.Hinder@utas.edu.au
Schmidt
Matthew W
MW
Garry
Michael I
MI
Summers
Jeffery J
JJ
D000328:Adult; D003627:Data Interpretation, Statistical; D004569:Electroencephalography; D004576:Electromyography; D030141:Feedback, Psychological / Q000502:physiology; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D008297:Male; D009044:Motor Cortex / Q000502:physiology*; D009119:Muscle Contraction / Q000502:physiology; D018482:Muscle, Skeletal / Q000502:physiology; D010775:Photic Stimulation; D013933:Thumb / Q000502:physiology*; D050781:Transcranial Magnetic Stimulation; D055815:Young Adult