title: A case of progressive hypertension preceding gemcitabine-associated thrombotic microangiopathy complicated by acute kidney injury and stroke.
abstract: Gemcitabine-associated thrombotic microangiopathy is being increasingly recognized as a serious complication of treatment. We report a normotensive patient who developed progressive hypertension after commencing gemcitabine therapy. She also developed subtle changes in her platelet count and serum creatinine months before her emergent presentation. Clinicians should be aware of new onset or worsening hypertension and 'mild' biochemical changes in gemcitabine-treated patients.
authors.affiliation: Department of Nephrology, Beaumont Hospital, Dublin 9, Ireland. paulphel@gmail.com
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Phelan
authors.forename: Aaron
authors.initials: A
authors.lastname: Liew
authors.forename: Colm
authors.initials: C
authors.lastname: Magee
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology*; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects*; D003841:Deoxycytidine / Q000009:adverse effects / Q000031:analogs & derivatives*; D018450:Disease Progression; D005260:Female; D006801:Humans; D006973:Hypertension / Q000139:chemically induced*; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000601:surgery; D020521:Stroke / Q000209:etiology*; D057049:Thrombotic Microangiopathies / Q000139:chemically induced*; D000093542:Gemcitabine
chemical_list: D000970:Antineoplastic Agents; D003841:Deoxycytidine; D000093542:Gemcitabine