title: Zn-mediated, Pd-catalyzed cross-couplings in water at room temperature without prior formation of organozinc reagents.
abstract: Mix in water, stir. That is all that is required in this new approach to sp(3)-sp(2) cross-couplings between an alkyl iodide and an aryl bromide, both potentially bearing functionality. They react under catalysis by Pd(0) in the presence of zinc powder, aided by a nonionic amphiphile, to give the alkylated aromatic. No organic solvents and no heating; just add water.
authors.affiliation: Department of Chemistry & Biochemistry, University of California, Santa Barbara, California 93106, USA.
authors.forename: Arkady
authors.initials: A
authors.lastname: Krasovskiy
authors.forename: Christophe
authors.initials: C
authors.lastname: Duplais
authors.forename: Bruce H
authors.initials: BH
authors.lastname: Lipshutz