title: [Rasburicase for tophaceus gout treatment].
abstract: The main obstacle to the treatment of hyperuricemia in patients with allergy to allopurinol is the limited availability of equally efficient alternative drugs. The authors present a clinical case of a patient with incapacitant tophaceus gout, allergy to allopurinol and contraindication for uricosurics, who was treated with rasburicase, an urato-oxidase recombinant, based on experience with this drug in tumoral lisis and in some cases reports of tophaceus gout. The authors also enhance the fact of being a patient with a sequelar hemiplegia of a previous cerebrovascular disease that presents tophus only in the not paretic member. The management of patients with allergy to allopurinol can be a clinical challenge, and the monthly rasburicase perfusions may be an alternative treatment of serious gout not treatable for other ways.
authors.affiliation: Interna Complementar de Reumatologia, Serviço Reumatologia, Unidade Local de Saúde do Alto Minho, Ponte de Lima. anaroxo79@iol.pt
authors.forename: Ana
authors.initials: A
authors.lastname: Ribeiro
authors.forename: Mónica
authors.initials: M
authors.lastname: Bogas
authors.forename: José
authors.initials: J
authors.lastname: Costa
authors.forename: Lúcia
authors.initials: L
authors.lastname: Costa
authors.forename: Domingos
authors.initials: D
authors.lastname: Araújo
mesh_terms: D005260:Female; D006073:Gout / Q000188:drug therapy*; D006074:Gout Suppressants / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D014503:Urate Oxidase / Q000627:therapeutic use*
chemical_list: D006074:Gout Suppressants; C469709:rasburicase; D014503:Urate Oxidase