DNA-hydrolyzing Ab: is catalytic activity a clue for physiological significance?
Ab with DNA-hydrolyzing properties were described in autoimmune pathologies, such as SLE and RA, and in other autoimmune diseases, including chronic lymphocytic leukemia, AIDS, and others. The disease-associated DNA-binding AAb penetrate cell membrane and enter the nucleus. Intracellular entry of anti-DNA was linked to cellular damage and apo. Here we discuss the possible pathological process induced by DNA-cleaving Ab in the nucleus, where these Ab may induce apo. Apo processes, e.g., induced by DNA-hydrolyzing Ab, may underlie a number of syndromes observed in autoimmunity thus providing the grounds for the pathological role of DNA-hydrolyzing Ab in these diseases.
Kozyr
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AV
M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, UI, Miklukho-Maklaya Street, 16/10, 117997 GSP, Moscow, V-437, Russia.
Gabibov
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AG
D017151:Antibodies, Catalytic / Q000276:immunology*; D017209:Apoptosis / Q000276:immunology*; D001323:Autoantibodies / Q000276:immunology; D001324:Autoantigens / Q000276:immunology; D001327:Autoimmune Diseases / Q000201:enzymology / Q000276:immunology*; D015551:Autoimmunity / Q000276:immunology*; D004247:DNA / Q000276:immunology*; D006801:Humans
D017151:Antibodies, Catalytic; D001323:Autoantibodies; D001324:Autoantigens; D004247:DNA