title: Bioorganic synthesis of end-capped anti-HIV peptides by simultaneous cyanocysteine-mediated cleavages of recombinant proteins.
abstract: Bioorganic synthesis of N- and C-terminal end-capped peptides by two simultaneous S-cyanocysteine-mediated cleavages of recombinant proteins is described. This approach is demonstrated in the preparation of anti-HIV fusion inhibitory peptides.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan.
authors.forename: Michinori
authors.initials: M
authors.lastname: Tanaka
authors.forename: Kazumi
authors.initials: K
authors.lastname: Kajiwara
authors.forename: Rei
authors.initials: R
authors.lastname: Tokiwa
authors.forename: Kentaro
authors.initials: K
authors.lastname: Watanabe
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Ohno
authors.forename: Hiroko
authors.initials: H
authors.lastname: Tsutsumi
authors.forename: Yoji
authors.initials: Y
authors.lastname: Hata
authors.forename: Kazuki
authors.initials: K
authors.lastname: Izumi
authors.forename: Eiichi
authors.initials: E
authors.lastname: Kodama
authors.forename: Masao
authors.initials: M
authors.lastname: Matsuoka
authors.forename: Shinya
authors.initials: S
authors.lastname: Oishi
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Fujii
mesh_terms: D000595:Amino Acid Sequence; D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D003545:Cysteine / Q000737:chemistry*; D023581:HIV Fusion Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D008969:Molecular Sequence Data; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011993:Recombinant Fusion Proteins / Q000378:metabolism*
chemical_list: D019380:Anti-HIV Agents; D023581:HIV Fusion Inhibitors; D010455:Peptides; D011993:Recombinant Fusion Proteins; D003545:Cysteine