[Parameters of the immune status in patients with allergic airway diseases with bacterial sensitization].
In-depth analysis was made to study immunological parameters in 188 patients with allergic airway diseases (AAD) and in 40 healthy individuals. No substantial changes were found in the count of CD3+, CD4+, CD20+, and CD8+ cells. However, in the patients with AAD, there was a significant reduction in the peripheral blood levels of natural killer and CD95+ cells, at the same time there was an increase in CD25+-activated lymphocytes and in the absolute content of CD8+ cells and total IgE. As compared with the healthy individuals, the patients with ADD had elevated IL-1 and IL-4 and decreased IFN-gamma in cytokine immunoregulation. Thus, the study conducted leads one to believe that AAD with bacterial sensitization is an immunopathological process with a predominance of a Th2-dependent immune response.
Baranova
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Kostina
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D000293:Adolescent; D000328:Adult; D000917:Antibody Formation; D000942:Antigens, Bacterial / Q000276:immunology*; D001249:Asthma / Q000276:immunology* / Q000382:microbiology; D001424:Bacterial Infections / Q000276:immunology*; D016207:Cytokines / Q000097:blood / Q000276:immunology; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D007136:Immunoglobulins / Q000097:blood; D016130:Immunophenotyping; D008297:Male; D008875:Middle Aged; D012221:Rhinitis, Allergic, Perennial / Q000276:immunology* / Q000382:microbiology; D018418:Th2 Cells / Q000276:immunology; D055815:Young Adult
D000942:Antigens, Bacterial; D016207:Cytokines; D007136:Immunoglobulins