Helicobacter pylori dupA gene is not associated with clinical outcomes in the Japanese population.
The dupA gene of Helicobacter pylori was suggested to be a risk factor for duodenal ulcer but protective against gastric cancer. The present study aimed to re-examine the role of dupA in H. pylori-infected Japanese patients. We found that dupA status was not associated with any gastroduodenal disease, histological score of chronic gastritis or with the extent of interleukin-8 production from gastric cell lines. These results indicate that dupA is unlikely to be a virulence factor of H. pylori in the Japanese population.
Nguyen
L T
LT
Department of Molecular Pathology, Faculty of Medicine, Oita University, Yufu City, Oita, Japan.
Uchida
T
T
Tsukamoto
Y
Y
Kuroda
A
A
Okimoto
T
T
Kodama
M
M
Murakami
K
K
Fujioka
T
T
Moriyama
M
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D005260:Female; D016481:Helicobacter Infections / Q000150:complications* / Q000382:microbiology / Q000473:pathology*; D016480:Helicobacter pylori / Q000472:pathogenicity*; D006801:Humans; D016209:Interleukin-8 / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D013270:Stomach / Q000276:immunology / Q000473:pathology; D016896:Treatment Outcome; D037521:Virulence Factors / Q000235:genetics*
C528428:DupA protein, Helicobacter pylori; D016209:Interleukin-8; D037521:Virulence Factors