title: Comparison of A1C and fasting glucose criteria to diagnose diabetes among U.S. adults.
abstract: OBJECTIVE
  To compare A1C and fasting glucose for the diagnosis of diabetes among U.S. adults.
  
  
  METHODS
  This study included 6,890 adults (> or =20 years of age) from the 1999-2006 National Health and Nutrition Examination Survey without a self-reported history of diabetes who had fasted > or =9 h. A1C > or =6.5% and fasting glucose > or =126 mg/dl were used, separately, to define diabetes.
  
  
  RESULTS
  Overall, 1.8% of U.S. adults had A1C > or =6.5% and fasting glucose > or =126 mg/dl, 0.5% had A1C > or =6.5% and fasting glucose <126 mg/dl, and 1.8% had A1C <6.5% and fasting glucose > or =126 mg/dl. Compared with individuals with A1C <6.5% and fasting glucose > or =126 mg/dl, individuals with A1C > or =6.5% and fasting glucose <126 mg/dl were younger, more likely to be non-Hispanic black, had lower Hb levels, and had higher C-reactive protein.
  
  
  CONCLUSIONS
  A1C > or =6.5% demonstrates reasonable agreement with fasting glucose for diagnosing diabetes among U.S. adults.
authors.affiliation: Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, USA. apcarson@uab.edu
authors.forename: April P
authors.initials: AP
authors.lastname: Carson
authors.forename: Kristi
authors.initials: K
authors.lastname: Reynolds
authors.forename: Vivian A
authors.initials: VA
authors.lastname: Fonseca
authors.forename: Paul
authors.initials: P
authors.lastname: Muntner
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis*; D003920:Diabetes Mellitus / Q000175:diagnosis*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity; D014481:United States
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin