Fatty liver and liver transplantation.
Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis are common complications of overnutrition and obesity. In the setting of worsening epidemics of obesity in developed and developing countries, the global prevalence and impact of NAFLD seems likely to increase. The large number of patients at risk will translate into major challenges for the liver transplant community, affecting donors and recipients. The comorbidities and hepatic effects of obesity and NAFLD present important new challenges in the management of donors and recipients. This article addresses some of these challenges.
Koehler
Edith
E
Department of Gastroenterology and Hepatology, Mayo Clinic and Foundation, Mayo Clinic Transplant Center, CH-10, 200 First Street S.W., Rochester, MN 55905, USA.
Watt
Kymberly
K
Charlton
Michael
M
D046148:Donor Selection; D005234:Fatty Liver / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology* / Q000473:pathology; D006801:Humans; D008103:Liver Cirrhosis / Q000601:surgery; D016031:Liver Transplantation; D019520:Living Donors; D009765:Obesity / Q000175:diagnosis / Q000453:epidemiology* / Q000473:pathology