Androgen replacement therapy and cardiovascular function.
Androgens play a primary role in female physiopathology. The age-related decline in the production of ovarian and adrenal androgens may significantly affect women's health. Scanty studies have been designed to establish whether androgen deficiency might directly affect cardiovascular biology and whether it might be a risk factor for cardiovascular disease in women during reproductive aging. The present short review examines the effect of androgen on the cardiovascular system, with particular regard to dehydroepiandrosterone and testosterone replacement in postmenopausal women.
Genazzani
A R
AR
Department of Reproductive Medicine and Child Development, Section of Gynecology and Obstetrics, University of Pisa, Pisa, Italy.
Pluchino
N
N
D000375:Aging / Q000097:blood / Q000502:physiology; D000728:Androgens / Q000172:deficiency* / Q000494:pharmacology*; D002318:Cardiovascular Diseases / Q000517:prevention & control*; D002319:Cardiovascular System / Q000187:drug effects*; D003687:Dehydroepiandrosterone / Q000494:pharmacology; D005260:Female; D006801:Humans; D017698:Postmenopause / Q000187:drug effects*; D012307:Risk Factors; D013739:Testosterone / Q000494:pharmacology
D000728:Androgens; D013739:Testosterone; D003687:Dehydroepiandrosterone