A view to a kill: how ligand quality controls lethal hits.
In this issue of Immunity, Beal et al. (2009) and Jenkins et al. (2009) demonstrate that relatively weak stimuli support synapse formation and microtubule polarization, but fail to trigger efficient killing because of their inability to recruit lytic granules to the synaptic cleft.
Bunnell
Stephen C
SC
Department of Pathology, Tufts University School of Medicine, Boston, MA 02111, USA.
D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D015550:Cell Degranulation / Q000276:immunology; D016764:Cell Polarity / Q000276:immunology; D003594:Cytoplasmic Granules / Q000276:immunology; D003602:Cytotoxicity, Immunologic / Q000276:immunology*; D006801:Humans; D054992:Immunological Synapses / Q000276:immunology* / Q000378:metabolism; D008024:Ligands; D008870:Microtubules / Q000276:immunology* / Q000378:metabolism; D011494:Protein Kinases / Q000276:immunology* / Q000378:metabolism; D011948:Receptors, Antigen, T-Cell / Q000276:immunology* / Q000378:metabolism; D015398:Signal Transduction / Q000276:immunology
D008024:Ligands; D011948:Receptors, Antigen, T-Cell; D011494:Protein Kinases