Plasma cell leukemia maintaining complete remission by syngeneic stem cell transplantation combined with low-dose thalidomide maintenance therapy.
Plasma cell leukemia (PCL) is a rare variant of multiple myeloma, which is very aggressive and resistant to chemotherapy. We report a case of PCL successfully treated with syngeneic peripheral blood stem cell transplantation followed by low-dose thalidomide. As of March 2009, the patient has maintained CR for 39 months posttransplant. The clinical course of the present case suggests that autologous stem cell transplantation using a graft with reduced contamination of malignant cells followed by low-dose thalidomide maintenance therapy may improve the PCL treatment outcome.
Abe
Masahiro
M
Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai.
Yokoyama
Hisayuki
H
Tohmiya
Yasuo
Y
Okitsu
Yoko
Y
Ohguchi
Hiroto
H
Kohata
Katsura
K
Yamamoto
Joji
J
Onishi
Yasushi
Y
Ishizawa
Kenichi
K
Kameoka
Junichi
J
Harigae
Hideo
H
D000328:Adult; D003131:Combined Modality Therapy; D006801:Humans; D007952:Leukemia, Plasma Cell / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery; D008297:Male; D012074:Remission Induction; D033581:Stem Cell Transplantation / Q000379:methods; D013792:Thalidomide / Q000008:administration & dosage*; D014185:Transplantation, Isogeneic / Q000379:methods
D013792:Thalidomide