title: Residual immunity in older people against the influenza A(H1N1)--recent experience in northern Spain.
abstract: The 2009 pandemic influenza A(H1N1) virus has a higher incidence in children and young adults, a pattern that has also been reported in seasonal influenza caused by the influenza A(H1N1)virus. We analysed age at infection in symptomatic patients with influenza in the Basque Country (northern Spain), reported through the sentinel influenza surveillance system which monitors 2.2-2.5%of the population. Between September 1999 and August 2009,influenza A(H3N2) or seasonal influenza A(H1N1) was detected in 941 patients, and from April to August 2009, pandemic influenza A(H1N1) was detected in 112 patients. The H3/H1 seasonal influenza ratio was between 3.3 and 3.4 in the under 60 year olds,but 9.8 in older individuals, suggesting that people born before 1950 have residual immunity against the influenza A H1N1 subtype (both seasonal and pandemic).
authors.affiliation: Microbiology Service and Reference Laboratory for Influenza Infections of the Basque Country, Hospital Donostia, San Sebastian, Spain. mikrobiol@terra.es
authors.forename: E
authors.initials: E
authors.lastname: Pérez-Trallero
authors.forename: L
authors.initials: L
authors.lastname: Piñeiro
authors.forename: D
authors.initials: D
authors.lastname: Vicente
authors.forename: M
authors.initials: M
authors.lastname: Montes
authors.forename: G
authors.initials: G
authors.lastname: Cilla
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D053118:Influenza A Virus, H1N1 Subtype; D007251:Influenza, Human / Q000453:epidemiology* / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D012621:Seasons; D013030:Spain / Q000453:epidemiology; D055815:Young Adult