Translate this ... during dietary restriction.
Several studies indicate that reduced TOR signaling underlies life span extension by dietary restriction. Recently, Zid et al. (Zid et al., 2009) linked the benefits of dietary restriction in flies to increased levels of the downstream TOR target 4E-BP1 and corresponding changes in the relative translation rates of classes of mRNAs.
Kennedy
Brian K
BK
Department of Biochemistry, University of Washington, Seattle, WA 98195, USA. bkenn@u.washington.edu
Mackay
Vivian L
VL
D000818:Animals; D031204:Caloric Restriction; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism; D004331:Drosophila melanogaster / Q000502:physiology; D047908:Intracellular Signaling Peptides and Proteins; D008136:Longevity / Q000235:genetics; D010448:Peptide Initiation Factors; D019869:Phosphatidylinositol 3-Kinases / Q000235:genetics / Q000378:metabolism; D014176:Protein Biosynthesis; D011494:Protein Kinases; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D058570:TOR Serine-Threonine Kinases
D029721:Drosophila Proteins; D047908:Intracellular Signaling Peptides and Proteins; D010448:Peptide Initiation Factors; D019869:Phosphatidylinositol 3-Kinases; D011494:Protein Kinases; D012333:RNA, Messenger; D058570:TOR Serine-Threonine Kinases; C410006:Thor protein, Drosophila; C416303:target of rapamycin protein, Drosophila