The effects of lipids on channel function.
Anionic lipids affect the function of many channels, including connexins, as shown in a recent report in BMC Biology. These effects might follow from direct binding of the anionic lipids to the channels.
Lee
Anthony G
AG
School of Biological Sciences, University of Southampton, Southampton, SO16 7PX, UK. agl@soton.ac.uk
D018528:ATP-Binding Cassette Transporters / Q000187:drug effects; D000838:Anions / Q000737:chemistry; D017630:Connexins / Q000494:pharmacology*; D017629:Gap Junctions / Q000187:drug effects* / Q000502:physiology; D006367:HeLa Cells; D006801:Humans; D015640:Ion Channel Gating / Q000187:drug effects / Q000502:physiology; D008055:Lipids / Q000494:pharmacology*; D021962:Membrane Microdomains / Q000187:drug effects; D008565:Membrane Proteins / Q000187:drug effects / Q000502:physiology; D016297:Mutagenesis, Site-Directed; D010712:Phosphatidic Acids / Q000494:pharmacology; D010713:Phosphatidylcholines / Q000494:pharmacology; D019269:Phosphatidylinositol 4,5-Diphosphate / Q000494:pharmacology; D024661:Potassium Channels, Inwardly Rectifying / Q000187:drug effects* / Q000502:physiology; D015222:Sodium Channels / Q000187:drug effects / Q000502:physiology
D018528:ATP-Binding Cassette Transporters; D000838:Anions; D017630:Connexins; D008055:Lipids; D008565:Membrane Proteins; D010712:Phosphatidic Acids; D010713:Phosphatidylcholines; D019269:Phosphatidylinositol 4,5-Diphosphate; D024661:Potassium Channels, Inwardly Rectifying; D015222:Sodium Channels