title: Effect of gavage treatment with pulverised Garcinia kola seeds on erythrocyte membrane integrity and selected haematological indices in male albino Wistar rats.
abstract: This study examines the effect of the whole seed of Garcinia kola [GKS] on various blood parameters, in adult male albino rats. Five groups, of 6 animals per group, were treated by gavage with suspensions of graded concentrations of GKS daily for 5 weeks. The animals were then sacrificed and blood was obtained for estimation of the data herein presented. Packed red cell volume [PCV], hemoglobin concentration [Hb], and red blood cell count [RBC] showed significantly [P<0.05], increased response to treatment with GKS; while the platelet and white blood cell [WBC] counts showed no corresponding increase with increasing GKS dosage. The mean red blood cell volume [MCV] and mean cell hemoglobin [MCH] levels decreased with increasing GKS dosage. Prothrombin time [PT] and activated partial thromboplastin time [APPT] were both prolonged with increased GKS dosage; while the serum lipids (cholesterol and triglycerides) decreased significantly [P<0.05] with increased GKS dosage.
authors.affiliation: Department of Pharmacology, Faculty of Basic Medical Sciences, University of Calabar, Calabar Nigeria.
authors.forename: A A
authors.initials: AA
authors.lastname: Ahumibe
authors.forename: V B
authors.initials: VB
authors.lastname: Braide
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D004305:Dose-Response Relationship, Drug; D004906:Erythrocyte Count; D004909:Erythrocyte Indices; D004910:Erythrocyte Membrane / Q000187:drug effects*; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism; D029763:Garcinia kola; D006400:Hematocrit; D006454:Hemoglobins / Q000378:metabolism; D006461:Hemolysis / Q000187:drug effects; D007962:Leukocytes; D008297:Male; D009996:Osmotic Fragility / Q000187:drug effects; D010314:Partial Thromboplastin Time; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D010976:Platelet Count; D011517:Prothrombin Time; D051381:Rats; D017208:Rats, Wistar; D012639:Seeds; D014280:Triglycerides / Q000097:blood
chemical_list: D006454:Hemoglobins; D010936:Plant Extracts; D014280:Triglycerides; D002784:Cholesterol