Sex determination: the power of DMRT1.
DMRT1, a mammalian gene related to sex-determining genes in flies and nematodes, is located in a region of the human genome that is important for sex development. This suggests that a common thread might run through the evolution of sex-determining mechanisms from worms to humans. New data show that DMRT1 can cause sex reversal in chickens, adding support to this hypothesis.
Koopman
Peter
P
Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia. p.koopman@imb.uq.edu.au
D000818:Animals; D002645:Chickens / Q000235:genetics; D014644:Genetic Variation; D006801:Humans; D019849:Sex Determination Processes; D014157:Transcription Factors / Q000235:genetics*
C110547:DMRT1 protein; D014157:Transcription Factors