Early response to family-based treatment for adolescent anorexia nervosa.
OBJECTIVE
The purpose of this study was to determine if early weight gain predicted remission at the end of treatment in a clinic sample of adolescents with anorexia nervosa (AN).


METHODS
Sixty five adolescents with AN (mean age = 14.9 years, SD = 2.1), from two sites (Chicago n = 45; Columbia n = 20) received a course of manualized family-based treatment (FBT). Response to treatment was assessed using percent ideal body weight (IBW) with remission defined as having achieved ≥ 95% IBW at end of treatment (Session 20).


RESULTS
Receiver operating characteristic analyses showed that a gain of at least 2.88% in ideal body weight by Session 4 best predicted remission at end of treatment (AUC = 0.674; p = 0.024).


CONCLUSIONS
Results suggest that adolescents with AN, receiving FBT, who do not show early weight gain are unlikely to remit at end of treatment.
Doyle
Peter M
PM
Department of Psychiatry and Behavioral Neuroscience, The University of Chicago, Chicago, Illinois 60637, USA. pdoyle@yoda.bsd.uchicago.edu
Le Grange
Daniel
D
Loeb
Katharine
K
Doyle
Angela Celio
AC
Crosby
Ross D
RD
D000293:Adolescent; D000856:Anorexia Nervosa / Q000175:diagnosis / Q000523:psychology* / Q000628:therapy*; D001835:Body Weight; D002641:Chicago; D005196:Family Therapy / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D009518:New York; D012372:ROC Curve; D013997:Time Factors; D016896:Treatment Outcome; D015430:Weight Gain / Q000502:physiology*