title: Perioperative management and outcome of general and abdominal surgery in hemophiliacs.
abstract: BACKGROUND
  The aim of the current study was to investigate perioperative management and outcome of surgery in hemophiliacs.
  
  
  METHODS
  Fifty-five hemophiliacs underwent surgery (appendectomy, cholecystectomy, inguinal hernia repair, hemorrhoidectomy). Surgical procedures in hemophiliacs and matched pairs were analyzed for duration of surgery, drainages, hospital stay, factor use (VIII, IX), and complications. Factor substitution was analyzed. Mann-Whitney U and Kruskal-Wallis tests were used (P < .05).
  
  
  RESULTS
  No significant differences were found for duration of drains and operation time in hemophiliacs versus matched pairs. Significance for duration of hospital stay compared with controls was found in hemophiliacs for appendectomy, inguinal hernia repair, and hemorrhoidectomy but not for cholecystectomy. In both groups, complications were low without significant differences.
  
  
  CONCLUSIONS
  This study found no significant differences in perioperative data and postoperative outcome in hemophiliacs compared with nonhemophiliacs due to the excellent perioperative interdisciplinary management at our Hemophilia Center with prolonged hospital stay in hemophiliacs.
authors.affiliation: Institute for Experimental Hematology and Transfusion Medicine, University of Bonn, Bonn, Germany.
authors.forename: Georg
authors.initials: G
authors.lastname: Goldmann
authors.forename: Yaroslava
authors.initials: Y
authors.lastname: Holoborodska
authors.forename: Johannes
authors.initials: J
authors.lastname: Oldenburg
authors.forename: Nico
authors.initials: N
authors.lastname: Schaefer
authors.forename: Tobias
authors.initials: T
authors.lastname: Hoeller
authors.forename: Jens
authors.initials: J
authors.lastname: Standop
authors.forename: Joerg C
authors.initials: JC
authors.lastname: Kalff
authors.forename: Andreas
authors.initials: A
authors.lastname: Hirner
authors.forename: Marcus
authors.initials: M
authors.lastname: Overhaus
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001803:Blood Transfusion / Q000379:methods* / Q000706:statistics & numerical data; D016022:Case-Control Studies; D002423:Cause of Death; D002648:Child; D013505:Digestive System Surgical Procedures / Q000009:adverse effects* / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D013502:General Surgery / Q000379:methods*; D006467:Hemophilia A / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*; D017052:Hospital Mortality / Q000639:trends*; D006801:Humans; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D019990:Perioperative Care / Q000379:methods; D011336:Probability; D012016:Reference Values; D012189:Retrospective Studies; D018570:Risk Assessment; D018709:Statistics, Nonparametric; D016019:Survival Analysis; D016896:Treatment Outcome; D055815:Young Adult