APOE epsilon4 is a high-risk factor for Alzheimer's disease in the Mongolian population.
To determine the relationship between apolipoprotein E (APOE) epsilon4 and sporadic Alzheimer's disease (SAD) in the Mongolian population in China, we examined 106 Mongolian SAD patients in China and 100 Mongolian healthy controls. All subjects were genotyped for APOE. The odds ratio (OR) for developing SAD was significantly increased in carriers of the APOE epsilon4 allele compared with APOE epsilon4 non-carriers (chi(2)=5.59, df=1, P=0.018, OR=1.84, 95% CI 1.02-3.31). Our findings suggested that APOE epsilon4 is a high-risk factor for AD in the Mongolian population in China. The present study is the first to establish the relationship between APOE epsilon4 and SAD in the Mongolian population.
Huriletemuer
Department of Neurology, The First Affiliated Hospital, Harbin Medical University, Harbin 150001, China.
Wang
Binbin
B
Wang
Jing
J
Wang
Guan
G
Zhang
Chunyu
C
Zhao
Shigang
S
Zhou
Sirui
S
Ma
Xu
X
Wang
De Sheng
de S
D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000453:epidemiology* / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics*; D004247:DNA / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D008986:Mongolia / Q000453:epidemiology; D010641:Phenotype; D011569:Psychiatric Status Rating Scales; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012307:Risk Factors
D001057:Apolipoproteins E; D004247:DNA