title: Synthesis of bis-Schiff bases of isatins and their antiglycation activity.
abstract: Bis-Schiff bases 1-27 have been synthesized and their in vitro antiglycation potential has been evaluated. Compounds 21 (IC(50)=243.95+/-4.59microM), 20 (IC(50)=257.61+/-5.63microM), and 7 (IC(50)=291.14+/-2.53microM) showed an excellent antiglycation activity better than the standard (rutin, IC(50)=294.46+/-1.50microM). This study has identified a series of potential molecules as antiglycation agents. A structure-activity relationship has been studied, and all the compounds were characterized by spectroscopic techniques.
authors.affiliation: H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University Karachi, Karachi 75270, Pakistan. hassaan2@super.net.pk
authors.forename: Khalid Mohammed
authors.initials: KM
authors.lastname: Khan
authors.forename: Momin
authors.initials: M
authors.lastname: Khan
authors.forename: Muhammad
authors.initials: M
authors.lastname: Ali
authors.forename: Muhammad
authors.initials: M
authors.lastname: Taha
authors.forename: Saima
authors.initials: S
authors.lastname: Rasheed
authors.forename: Shahnaz
authors.initials: S
authors.lastname: Perveen
authors.forename: M Iqbal
authors.initials: MI
authors.lastname: Choudhary
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D005947:Glucose / Q000378:metabolism*; D006031:Glycosylation / Q000187:drug effects; D020128:Inhibitory Concentration 50; D007510:Isatin / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D012545:Schiff Bases / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013057:Spectrum Analysis
chemical_list: D000900:Anti-Bacterial Agents; D012545:Schiff Bases; D007510:Isatin; D005947:Glucose