Neuroblastoma involvement of the falx cerebri.
Involvement of the falx cerebri in infants with stage 4 neuroblastoma is thought to be rare. The falx is derived from the neural crest and thus may be a location for primary neuroblastoma. Its propensity for metastasis is unknown. Management of neuroblastoma in this location is potentially challenging. We describe two children less than 18 months of age who were successfully managed with chemotherapy alone (without radiation or surgery) for falx involvement with neuroblastoma.
Quackenbush
Katherine Elizabeth
KE
Dalhousie University, Halifax, Nova Scotia, Canada.
Luna-Fineman
Sandra
S
Magee
James Fergall
JF
Gundogan
Munire
M
Golobi
Mahin
M
Irie
Takeshi
T
Fernandez
Conrad Vincent
CV
D000310:Adrenal Gland Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D000315:Adrenalectomy; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage; D019070:Cell Lineage; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D004388:Dura Mater / Q000473:pathology*; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008577:Meningeal Neoplasms / Q000188:drug therapy / Q000556:secondary*; D051739:Microphthalmia-Associated Transcription Factor / Q000235:genetics; D009367:Neoplasm Staging; D009432:Neural Crest; D009447:Neuroblastoma / Q000188:drug therapy / Q000235:genetics / Q000473:pathology / Q000556:secondary* / Q000601:surgery; D011667:Pulmonary Veins / Q000002:abnormalities; D012074:Remission Induction; D012878:Skin Neoplasms / Q000188:drug therapy / Q000556:secondary; D014849:Waardenburg Syndrome / Q000150:complications / Q000235:genetics
C497234:MITF protein, human; D051739:Microphthalmia-Associated Transcription Factor; D005047:Etoposide; D004317:Doxorubicin; D003520:Cyclophosphamide; D016190:Carboplatin