[P73 gene expression in colorectal adenocarcinoma: a prognostic or etiopathogenetic factor?].
BACKGROUND
The p73 gene encodes a nuclear protein that is highy homologous to p53. p73 also shares some common functions with p53 protein indicating that p73 gene is a p53-like tumor suppressor.


OBJECTIVE
In this study, we examined by immunohistochemestry the p73 expression on 120 cases of colorectal carcinomas and evaluated its implication in carcinogenesis.


METHODS
Retrospective study.


RESULTS
The results show an increase of intensity and distribution of p73 in common adenocarcinoma from the normal mucosa, to primery tumors and to metastases. However, in mucinous adenocarcinomas, immunostaining of p73 decrease in primary tumor and completely diseappears in isolated cells and metastases compared with matched normal mucosa. These observations are further reinforced by the fact that in adenocarcinoma with mucinous component less than 50%, the positivity of p73 persist in well-differentiated areas and dramatically decreases or completely deseappears in mucinous areas.


CONCLUSIONS
In conclusion, p73 would be a prognosic marker for the common adenocarcinomas and an ethiopathogenic factor for the mucinous subtype.
Ben Mahmoud
Lilia Kria
LK
Unité de recherche (M.E.S..R.S): UR/99/08-58.
Toumi
Amira Arfaoui
AA
Chaâr
Ines
I
Lahmer
Ahlem
A
Khalfallah
Tahar
T
Mzabi
Sabeh Regaya
SR
Bouraoui
Saadia
S
D000230:Adenocarcinoma / Q000235:genetics* / Q000378:metabolism; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D009687:Nuclear Proteins / Q000378:metabolism*; D011379:Prognosis; D012189:Retrospective Studies; D000072160:Tumor Protein p73; D025521:Tumor Suppressor Proteins / Q000378:metabolism*
D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; C000606460:TP73 protein, human; D000072160:Tumor Protein p73; D025521:Tumor Suppressor Proteins