title: Phalangeal quantitative ultrasound and bone mineral density in evaluating cortical bone loss: a study in postmenopausal women with primary hyperparathyroidism and subclinical iatrogenic hyperthyroidism.
abstract: Twenty-five postmenopausal women with primary hyperparathyroidism (PHPT) and 30 age-matched women with subclinical hyperthyroidism (sHTH) were studied to assess cortical bone loss. One hundred two healthy women were also recruited. Bone mineral density (BMD) was measured by dual-energy X-ray absorptiometry at lumbar spine (LS), femoral neck (FN) and femoral total (FT), and at one-third of the radius (R). Amplitude-dependent speed of sound (ADSoS) and Ultrasound Bone Profile Index (UBPI) were also evaluated using phalangeal quantitative ultrasound (QUS). A significant correlation was found between QUS and BMD at LS (ADSoS, p < 0.05) and R (ADSoS and UBPI, p < 0.001) in controls. QUS significantly correlated with BMD at LS, FN (p < 0.01), and FT (p < 0.001) in sHTH. No correlations were found in the PHPT group. Mean T-score values of all parameters were significantly lower in patients compared with controls (p < 0.001); however, they did not differ between PHPT and sHTH patients. T-score of R, ADSoS, and UBPI was reduced compared with other sites (p < 0.001) in both diseases. In postmenopausal women with PHPT and sHTH, bone loss is mainly detectable at cortical level. However, qualitative and/or structural changes of bone could account for the lack of correlations between these 2 techniques at cortical sites.
authors.affiliation: Department of Clinical Sciences, University of Rome Sapienza, Rome, Italy.
authors.forename: Cristiana
authors.initials: C
authors.lastname: Cipriani
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Romagnoli
authors.forename: Addolorata
authors.initials: A
authors.lastname: Scarpiello
authors.forename: Maurizio
authors.initials: M
authors.lastname: Angelozzi
authors.forename: Teresa
authors.initials: T
authors.lastname: Montesano
authors.forename: Salvatore
authors.initials: S
authors.lastname: Minisola
mesh_terms: D000328:Adult; D000368:Aged; D015519:Bone Density; D003937:Diagnosis, Differential; D018450:Disease Progression; D005260:Female; D005269:Femur / Q000000981:diagnostic imaging; D050278:Finger Phalanges / Q000000981:diagnostic imaging*; D005500:Follow-Up Studies; D006801:Humans; D049950:Hyperparathyroidism, Primary / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D006980:Hyperthyroidism / Q000097:blood / Q000139:chemically induced* / Q000150:complications; D007049:Iatrogenic Disease; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000150:complications* / Q000175:diagnosis; D010281:Parathyroid Hormone / Q000097:blood; D017698:Postmenopause; D011859:Radiography; D013974:Thyroxine / Q000009:adverse effects*; D014463:Ultrasonography; D055815:Young Adult
chemical_list: D010281:Parathyroid Hormone; D013974:Thyroxine