The central role of Bcl-3 in atopic dermatitis.
Cytokines and hormones are essential mediators in the regulation of antimicrobial peptide and protein (AMP) levels during host defense responses. In this issue, Büchau et al. identify and characterize B-cell leukemia-3 as an important modulator of AMP expression during the innate immune response in keratinocytes as well as in the chronic inflammatory skin disorder atopic dermatitis.
Massoumi
Ramin
R
Department of Laboratory Medicine, Lund University, Malmö University Hospital, Malmö, Sweden.
D023181:Antimicrobial Cationic Peptides / Q000235:genetics / Q000502:physiology; D000081242:B-Cell Lymphoma 3 Protein; D003876:Dermatitis, Atopic / Q000209:etiology* / Q000276:immunology / Q000628:therapy; D006801:Humans; D007113:Immunity, Innate; D015603:Keratinocytes / Q000276:immunology; D011518:Proto-Oncogene Proteins / Q000502:physiology*; D014157:Transcription Factors / Q000502:physiology*; D014807:Vitamin D / Q000008:administration & dosage; D054804:Cathelicidins
D023181:Antimicrobial Cationic Peptides; D000081242:B-Cell Lymphoma 3 Protein; C000631344:BCL3 protein, human; D011518:Proto-Oncogene Proteins; D014157:Transcription Factors; D014807:Vitamin D; D054804:Cathelicidins