title: Incipient primary biliary cirrhosis/autoimmune hepatitis overlap or hepatitic form of primary biliary cirrhosis: a case report.
abstract: A 42 year old asymptomatic female detected as incipient Primary Biliary Cirrhosis/Autoimmune Hepatitis overlap during routine checkup. The biochemical profile showed evolution from a mildly deranged liver function test in 2004 along with increased erythrocyte sedimentation rate to a 4 times elevation of alkaline phosphatase in 2006 with mildly deranged alanine transaminase. Autoimmune markers demonstrable were Anti mitochondrial antibody M(2) and sp100. Histopathology showed dual features, dominant findings were of autoimmune heptatitis. Features consistent with Primary Biliary Cirrhosis were minimal with an occasional portal tract showing paucity of bile ducts and occasional bile duct proliferation. Human leucocyte antigen DR/DQ genotype was as follows: DRB1*03, DRB1*07, DQB1*02, DQB1*04.
authors.affiliation: Department of Immunopathology, Postgraduate Institute of Medical Education & Research, Sector-12,Chandigarh - 160 012, India. rwminz@hotmail.com
authors.forename: Ranjana W
authors.initials: RW
authors.lastname: Minz
authors.forename: Seema
authors.initials: S
authors.lastname: Chhabra
authors.forename: Ritu
authors.initials: R
authors.lastname: Aggarwal
authors.forename: Ashim
authors.initials: A
authors.lastname: Das
authors.forename: Biman
authors.initials: B
authors.lastname: Saikia
authors.forename: Yogesh K
authors.initials: YK
authors.lastname: Chawla