Pemetrexed-induced pneumonitis: a case report.
Pemetrexed is a structurally novel antifolate agent approved in combination with cisplatin for the treatment of patients with malignant pleural mesothelioma who have unresectable disease and for the therapy of previously treated patients with locally advanced or metastatic non-small-cell lung cancer (NSCLC) as a single agent or in association with cisplatin as a first-line treatment in patients with nonsquamous histology. Herein, we report a case of pemetrexed-induced pneumonitis. Because pemetrexed is being prescribed with increasing frequency for NSCLC and mesothelioma, we believe that physicians should be aware of this rare but serious complication.
Loriot
Yohann
Y
Department of Medicine, SITEP, Institut Gustave Roussy, Universite Paris XI, and Department of Pneumology, Hôpital Tenon, Marie Curie, Paris VI, France.
Ferte
Charles
C
Gomez-Roca
Carlos
C
Moldovan
Christian
C
Bahleda
Ratislav
R
Wislez
Marie
M
Cadranel
Jacques
J
Soria
Jean-Charles
JC
D000305:Adrenal Cortex Hormones / Q000008:administration & dosage; D000368:Aged; D000890:Anti-Infective Agents / Q000008:administration & dosage; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D002939:Ciprofloxacin / Q000008:administration & dosage; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects; D004342:Drug Hypersensitivity / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D004359:Drug Therapy, Combination; D004417:Dyspnea; D004890:Erythema; D005971:Glutamates / Q000008:administration & dosage / Q000009:adverse effects; D006147:Guanine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives; D006801:Humans; D008168:Lung / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008175:Lung Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D008297:Male; D009364:Neoplasm Recurrence, Local; D017239:Paclitaxel / Q000008:administration & dosage; D000068437:Pemetrexed; D011014:Pneumonia / Q000139:chemically induced / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D011658:Pulmonary Fibrosis; D020127:Recovery of Function; D003074:Solitary Pulmonary Nodule / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology
D000305:Adrenal Cortex Hormones; D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D005971:Glutamates; D000068437:Pemetrexed; D002939:Ciprofloxacin; D006147:Guanine; D017239:Paclitaxel; D002945:Cisplatin