title: Immunologically silent cancer clone transmission from mother to offspring.
abstract: Rare cases of possible materno-fetal transmission of cancer have been recorded over the past 100 years but evidence for a shared cancer clone has been very limited. We provide genetic evidence for mother to offspring transmission, in utero, of a leukemic cell clone. Maternal and infant cancer clones shared the same unique BCR-ABL1 genomic fusion sequence, indicating a shared, single-cell origin. Microsatellite markers in the infant cancer were all of maternal origin. Additionally, the infant, maternally-derived cancer cells had a major deletion on one copy of chromosome 6p that included deletion of HLA alleles that were not inherited by the infant (i.e., foreign to the infant), suggesting a possible mechanism for immune evasion.
authors.affiliation: Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 1138519, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Isoda
authors.forename: Anthony M
authors.initials: AM
authors.lastname: Ford
authors.forename: Daisuke
authors.initials: D
authors.lastname: Tomizawa
authors.forename: Frederik W
authors.initials: FW
authors.lastname: van Delft
authors.forename: David Gonzalez
authors.initials: DG
authors.lastname: De Castro
authors.forename: Norkio
authors.initials: N
authors.lastname: Mitsuiki
authors.forename: Joannah
authors.initials: J
authors.lastname: Score
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Taki
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Morio
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Takagi
authors.forename: Hiroh
authors.initials: H
authors.lastname: Saji
authors.forename: Mel
authors.initials: M
authors.lastname: Greaves
authors.forename: Shuki
authors.initials: S
authors.lastname: Mizutani
mesh_terms: D000328:Adult; D001483:Base Sequence; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D016313:Genes, abl; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D007223:Infant; D019656:Loss of Heterozygosity; D008431:Maternal-Fetal Exchange / Q000235:genetics* / Q000276:immunology*; D018895:Microsatellite Repeats; D010677:Philadelphia Chromosome; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000235:genetics / Q000276:immunology; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000235:genetics* / Q000276:immunology*; D012333:RNA, Messenger / Q000235:genetics; D012334:RNA, Neoplasm / Q000235:genetics
chemical_list: D004273:DNA, Neoplasm; D006680:HLA Antigens; D012333:RNA, Messenger; D012334:RNA, Neoplasm