Increased ceruloplasmin and fibrinogen in type 2 diabetes corresponds to decreased anti-oxidant activity in a preliminary tertiary South Indian hospital study.
The relationship between type 2 diabetes, antioxidant-enzyme serum ceruloplasmin, pro-inflammatory blood fibrinogen and antioxidant activity (AOA) was investigated in 40 diabetics and 47 non-diabetics hailing from South India as a preliminary study aspiring to be a crucial stepping stone for a large study. Serum AOA was lower (p<0.01) in diabetics (0.68+/-0.03 mmol/L) than controls (0.92+/-0.07 mmol/L) and ceruloplasmin more (p<0.001) in diabetics (983.20+/-52.18 mg/L) than controls (470.79+/-39.20 mg/L). Plasma fibrinogen was higher (p<0.001) in diabetics (480.23+/-19.52 mg/dl) than controls (313.94+/-13.42 mg/dl). Males had more AOA. Fibrinogen increased with age. These significant findings point strongly to augmented oxidative stress and inflammatory states in South Indian diabetics.
Chacko
S K
SK
MBBS Program, Father Muller Medical College, Kankanady, Mangalore, Karnataka, India.
Cheluvappa
R
R
D000328:Adult; D000368:Aged; D000375:Aging; D000428:Alcohol Drinking; D000975:Antioxidants / Q000032:analysis; D002570:Ceruloplasmin / Q000032:analysis*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005260:Female; D005340:Fibrinogen / Q000032:analysis*; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007194:India; D007249:Inflammation / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D010865:Pilot Projects; D012727:Sex Characteristics; D012907:Smoking; D055815:Young Adult
D000975:Antioxidants; D002570:Ceruloplasmin; D005340:Fibrinogen; D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human