Perfusion preservation of the donor heart: basic science to pre-clinical.
As a consequence of technology improvements and refinement, perfusion of the donor heart has moved from the research laboratory to clinical studies. Multiple investigators are currently leading pre-clinical trials of devices using perfusion preservation, and one device is now in European clinical trials. One major problem with the donor heart is the high metabolism relative to other organs, and depletion of ATP leads rapidly to acidosis and necrosis of the myocardium. Two techniques in development to address the issue are normothermic and hypothermic perfusion. This review examines the current issues regarding donor heart preservation and techniques of preclinical evaluation necessary for regulatory approval.
Rivard
Andrew L
AL
Department of Surgery, Experimental Surgical Services, University of Minnesota, Minneapolis, Minnesota, USA. rivar011@umn.edu
Gallegos
Robert
R
Ogden
Irene M
IM
Bianco
Richard W
RW
D000818:Animals; D006321:Heart / Q000502:physiology*; D006324:Heart Arrest, Induced / Q000592:standards; D016027:Heart Transplantation; D006801:Humans; D023421:Models, Animal; D009926:Organ Preservation; D014481:United States; D014486:United States Food and Drug Administration / Q000592:standards