title: VEGF -460C>T polymorphism and cancer risk: a meta-analysis.
abstract: Vascular endothelial growth factor (VEGF) is a major driver of physiological and pathological angiogenesis and plays important roles in the etiology and metastasis of cancers. The -460C>T polymorphism in VEGF gene region has been implicated in cancer risk and related to VEGF expression. However, published data remain conflicting. To derive a more precise estimation, a meta-analysis of 5,863 cases and 5,276 controls from 14 published case-control studies was performed. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated to assess the association. VEGF -460T represented a risk factor for cancers in Asians (OR=1.69, 95% CI: 1.09-2.62) but not in Europeans (OR=0.92, 95% CI: 0.78-1.08). Our meta-analysis showed the evidence that VEGF -460T was associated with increased cancer risk in Asians. Further prospective researches with larger numbers of worldwide participants are expected to validate this result.
authors.affiliation: Department of Urology, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, 210029, Nanjing, China. xb15896450810@126.com
authors.forename: Bin
authors.initials: B
authors.lastname: Xu
authors.forename: Ning-Han
authors.initials: NH
authors.lastname: Feng
authors.forename: Na
authors.initials: N
authors.lastname: Tong
authors.forename: Zi-Dun
authors.initials: ZD
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Hong-Fei
authors.initials: HF
authors.lastname: Wu
authors.forename: Lin-Xin
authors.initials: LX
authors.lastname: Hua
mesh_terms: D016022:Case-Control Studies; D005006:Ethnicity; D006801:Humans; D009369:Neoplasms / Q000208:ethnology / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*
chemical_list: C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A