title: The effects of osteoformin on mineralisation and quality of newly formed bone during mandibular distraction osteogenesis in rabbits.
abstract: OBJECTIVE
  The aim of this experimental study was to evaluate the effects of osteoformin on mineralization and quality of newly formed bone during distraction osteogenesis in rabbits.
  
  
  METHODS
  Distraction rate was as 1 mm/day for 5 days. In the experimental group, 100 microg/kg osteoformin in 100 microL/kg phosphate-buffered saline (PBS) was injected into the distraction area at day 1 and day 7 after surgery. In the control group, only 100 microL/kg PBS was injected on the same days. On day 42, the animals were killed.
  
  
  RESULTS
  Bone mineral density and bone mineral content values increased significantly in the experimental group (P < .05). Newly formed bone areas, number of vessels and osteoblasts were significantly greater in experimental group (P < .05). The number of fibroblasts were also greater, but it was not significant statistically (P > .05). The number of osteoclasts was significantly lower in experimental group (P < .05).
  
  
  CONCLUSIONS
  The results of this study show that osteoformin improves healing of regenerate in distraction osteogenesis in rabbits.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Karadeniz Technical University, Trabzon, Turkey. alperpampu@hotmail.com
authors.forename: A Alper
authors.initials: AA
authors.lastname: Pampu
authors.forename: Ozkan
authors.initials: O
authors.lastname: Ozkaynak
authors.forename: Figen Cizmeci
authors.initials: FC
authors.lastname: Senel
authors.forename: Mustafa
authors.initials: M
authors.lastname: Cankaya
authors.forename: Doğan
authors.initials: D
authors.lastname: Dolanmaz
authors.forename: Safak
authors.initials: S
authors.lastname: Ersöz
authors.forename: Mustafa Cihat
authors.initials: MC
authors.lastname: Avunduk
mesh_terms: D000818:Animals; D015519:Bone Density / Q000187:drug effects / Q000502:physiology; D001861:Bone Regeneration / Q000187:drug effects / Q000502:physiology*; D002113:Calcification, Physiologic / Q000187:drug effects / Q000502:physiology*; D008297:Male; D008334:Mandible / Q000187:drug effects / Q000601:surgery*; D019186:Mandibular Advancement / Q000379:methods; D010012:Osteogenesis / Q000187:drug effects / Q000502:physiology*; D019857:Osteogenesis, Distraction / Q000379:methods*; D010455:Peptides / Q000008:administration & dosage / Q000502:physiology*; D011108:Polymers / Q000008:administration & dosage; D011817:Rabbits; D011897:Random Allocation
chemical_list: D010455:Peptides; D011108:Polymers; C017645:polyaspartate