Ultrasound-assisted one-pot, three-component synthesis of spiro[indoline-3,4'-pyrazolo[3,4-b]pyridine]-2,6'(1'H)-diones in water.
A simple, facile, efficient and three-component procedure for the synthesis of spiro[indoline-3,4'-pyrazolo[3,4-b]pyridine]-2,6'(1'H)-diones by the reaction of 4-hydroxycumarin, isatins and 1H-pyrazol-5-amines in water under ultrasonic irradiation is reported. The advantages of this method are the use of an inexpensive and readily available catalyst, easy work-up, good yields, and the use of water as a solvent that is considered to be relatively environmentally benign.
Bazgir
Ayoob
A
Department of Chemistry, Shahid Beheshti University G.C., Tehran, Iran. a_bazgir@sbu.ac.ir
Ahadi
Somayeh
S
Ghahremanzadeh
Ramin
R
Khavasi
Hamid Reza
HR
Mirzaei
Peiman
P
D015110:4-Hydroxycoumarins / Q000737:chemistry; D002384:Catalysis; D002625:Chemistry, Organic / Q000379:methods; D055772:Green Chemistry Technology; D007211:Indoles / Q000737:chemistry; D007510:Isatin / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D011720:Pyrazoles / Q000737:chemistry; D011728:Pyridones / Q000138:chemical synthesis* / Q000737:chemistry; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D014465:Ultrasonics; D014867:Water / Q000737:chemistry*
D015110:4-Hydroxycoumarins; D007211:Indoles; D011720:Pyrazoles; D011728:Pyridones; D013141:Spiro Compounds; D014867:Water; D007510:Isatin; C068805:4-hydroxycoumarin