title: Acetazolamide-induced vasodilation does not inhibit the visually evoked flow response.
abstract: Different methods are used to assess the vasodilator ability of cerebral blood vessels; however, the exact mechanism of cerebral vasodilation, induced by different stimuli, is not entirely known. Our aim was to investigate whether the potent vasodilator agent, acetazolamide (AZ), inhibits the neurovascular coupling, which also requires vasodilation. Therefore, visually evoked flow parameters were examined by transcranial Doppler in ten healthy subjects before and after AZ administration. Pulsatility index and peak systolic flow velocity changes, evoked by visual stimulus, were recorded in the posterior cerebral arteries before and after intravenous administration of 15 mg/kg AZ. Repeated-measures ANOVA did not show significant group main effect between the visually evoked relative flow velocity time courses before and after AZ provocation (P=0.43). Visual stimulation induced significant increase of relative flow velocity and decrease of pulsatility index not only before but also at the maximal effect of AZ. These results suggest that maximal cerebral vasodilation cannot be determined by the clinically accepted dose of AZ (15 mg/kg) and prove that neurovascular coupling remains preserved despite AZ-induced vasodilation. Our observation indicates independent regulation of vasodilation during neurovascular coupling, allowing the adaptation of cerebral blood flow according to neuronal activity even if other processes require significant vasodilation.
authors.affiliation: Department of Neurology, University of Debrecen, Debrecen H-4032, Hungary.
authors.forename: Yaniv
authors.initials: Y
authors.lastname: Yonai
authors.forename: Neta
authors.initials: N
authors.lastname: Boms
authors.forename: Sandor
authors.initials: S
authors.lastname: Molnar
authors.forename: Bernhard
authors.initials: B
authors.lastname: Rosengarten
authors.forename: Natan M
authors.initials: NM
authors.lastname: Bornstein
authors.forename: Laszlo
authors.initials: L
authors.lastname: Csiba
authors.forename: Laszlo
authors.initials: L
authors.lastname: Olah
mesh_terms: D000086:Acetazolamide / Q000494:pharmacology*; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D002560:Cerebrovascular Circulation / Q000187:drug effects* / Q000502:physiology*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D010775:Photic Stimulation; D011932:Reading; D017585:Ultrasonography, Doppler, Transcranial; D014664:Vasodilation / Q000187:drug effects*; D014665:Vasodilator Agents / Q000494:pharmacology*; D055815:Young Adult
chemical_list: D014665:Vasodilator Agents; D000086:Acetazolamide