Serum levels of the adipokine chemerin in relation to renal function.
OBJECTIVE
To investigate serum levels of the adipokine chemerin in patients on chronic hemodialysis (CD) as compared with control patients with a glomerular filtration rate (GFR) >50 ml/min.


METHODS
Chemerin was quantified by ELISA in control patients (n = 60) and CD patients (n = 60) and correlated with clinical and biochemical measures of renal function, glucose, and lipid metabolism, as well as inflammation, in both groups.


RESULTS
Median serum chemerin levels were more than twofold higher in CD patients (542.2 microg/l) compared with subjects with a GFR >50 ml/min (254.3 microg/l) (P < 0.001). Furthermore, GFR, as assessed by the original Modification of Diet in Renal Disease formula, independently predicted circulating chemerin concentrations in multiple regression analyses in both control patients (P < 0.05) and CD patients (P < 0.01).


CONCLUSIONS
We demonstrate that markers of renal function are independently related to circulating chemerin levels.
Pfau
Dörte
D
Department of Internal Medicine III, University of Leipzig, Leipzig, Germany.
Bachmann
Anette
A
Lössner
Ulrike
U
Kratzsch
Jürgen
J
Blüher
Matthias
M
Stumvoll
Michael
M
Fasshauer
Mathias
M
D000368:Aged; D000369:Aged, 80 and over; D018925:Chemokines / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D007668:Kidney / Q000378:metabolism*; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis
D018925:Chemokines; D036341:Intercellular Signaling Peptides and Proteins; C478630:RARRES2 protein, human