A new technique for inducing and releasing obstructive jaundice in rats.
OBJECTIVE
It was the aim of this study to develop a simple, effective and reversible model of obstructive jaundice in rats.


METHODS
Totally, 24 rats were divided into 3 groups: the sham group including sham-operated control rats who underwent laparotomy only (n = 8), the common bile duct standard ligation technique (CBD-SL) group including rats with CBD ligation using silk (n = 8), and the CBD new ligation technique (CBD-NL) group consisting of rats with CBD ligation by a new technique (n = 8). After release of the ligations, the CBD-SL group continued as the CBD-SL releasing group, and the CBD-NL group as the CBD-NL releasing group.


RESULTS
It was observed that all the CBD ligated rats were both clinically and biochemically jaundiced but they were relieved after reversing the procedure.


CONCLUSIONS
We present a simple, effective and reliable rat model which is suitable for studies which require a reversal of obstructive jaundice in rats.
Oruç
M T
MT
7th Surgical Department, Ankara Numune Teaching and Research Hospital, Ankara, Turkey. mtoruc @ yahoo.com
Ozmen
M M
MM
Han
U
U
D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001663:Bilirubin / Q000097:blood; D003135:Common Bile Duct / Q000601:surgery; D004195:Disease Models, Animal; D041781:Jaundice, Obstructive / Q000097:blood / Q000209:etiology* / Q000473:pathology / Q000601:surgery*; D007728:Kupffer Cells / Q000473:pathology; D008026:Ligation / Q000379:methods; D008099:Liver / Q000473:pathology; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D000469:Alkaline Phosphatase; D001663:Bilirubin