title: Burden of severe rotavirus diarrhea in indonesia.
abstract: Globally, rotavirus is the leading cause of diarrhea-related hospitalizations and deaths among young children, but the burden of rotavirus disease in Indonesia is poorly documented. From January through December 2006, we conducted prospective surveillance (inpatient and outpatient) among children aged <5 years at 6 hospitals in 6 provinces of Indonesia, using standardized methodology. Of 2240 enrolled children hospitalized for diarrhea, 1345 (60%) were rotavirus positive. Of 176 children enrolled in outpatient clinics in 3 hospitals, 73 (41%) were rotavirus positive. Among children hospitalized for diarrhea, dehydration was more common among those who tested positive for rotavirus than among those who did not (91% vs 82%; P < .05), as was vomiting (86% vs 67%; P < .05). Children aged 6-23 months experienced 72% of all rotavirus episodes. Rotavirus prevalence increased slightly in the cool, dry season. The most commonly detected genotypes were G9 (30%) and P[6] (56%). G1P[6] and G9P[6] accounted for 34% and 21% of strains, respectively. A high proportion of genotype P[6] was detected, in combination with the common G types G1 and G9. Available rotavirus vaccines would likely be efficacious against the most common circulating strains, but continued monitoring of uncommon genotypes is needed.
authors.affiliation: Departments of Child Health, Faculty of Medicine, Gadjah Mada University, Sardjito Hospital, Yogyakarta.
authors.forename: Yati
authors.initials: Y
authors.lastname: Soenarto
authors.forename: Abu T
authors.initials: AT
authors.lastname: Aman
authors.forename: Achirul
authors.initials: A
authors.lastname: Bakri
authors.forename: Herman
authors.initials: H
authors.lastname: Waluya
authors.forename: Agus
authors.initials: A
authors.lastname: Firmansyah
authors.forename: Muzal
authors.initials: M
authors.lastname: Kadim
authors.forename: Iesje
authors.initials: I
authors.lastname: Martiza
authors.forename: Dwi
authors.initials: D
authors.lastname: Prasetyo
authors.forename: Nenny S
authors.initials: NS
authors.lastname: Mulyani
authors.forename: Titis
authors.initials: T
authors.lastname: Widowati
authors.lastname: Soetjiningsih
authors.forename: I Putu Gede
authors.initials: IP
authors.lastname: Karyana
authors.forename: Wayan
authors.initials: W
authors.lastname: Sukardi
authors.forename: Joseph
authors.initials: J
authors.lastname: Bresee
authors.forename: Marc-Alain
authors.initials: MA
authors.lastname: Widdowson
mesh_terms: D002675:Child, Preschool; D017281:Cost of Illness; D003967:Diarrhea / Q000453:epidemiology*; D005838:Genotype; D006801:Humans; D007214:Indonesia / Q000453:epidemiology; D007223:Infant; D007231:Infant, Newborn; D012401:Rotavirus / Q000145:classification / Q000235:genetics; D012400:Rotavirus Infections / Q000453:epidemiology* / Q000821:virology; D012621:Seasons