Lack of association between the cholesteryl ester transfer protein gene--TaqIB polymorphism and coronary restenosis following percutaneous transluminal coronary angioplasty and stenting: a pilot study.
BACKGROUND
The most widely studied variation at the cholesteryl ester transfer protein (CETP) gene locus is a silent base change called the Thermobius aquaticus IB (TaqIB) polymorphism. TaqIB has been shown to affect levels/activity of CETP, plasma levels of high-density lipoprotein cholesterol (HDL-C), and to contribute to the risk of developing atherosclerosis and coronary heart disease (CHD). Ongoing studies are investigating possible associations between CETP gene polymorphisms and the development of coronary restenosis following percutaneous transluminal coronary angioplasty (PTCA) and stenting.


RESULTS
The primary objective of the present study was to investigate the frequency of TaqIB-polymorphism, and a possible association with post-PTCA coronary restenosis, in 204 Greek patients who had undergone PTCA and stenting. As a secondary objective, the analysis was extended to explore possible interacting or additive effects by various CHD risk factors, and a deletion in the alpha(2B)-adrenergic receptor gene. The frequency of TaqIB was 54%, similar to the frequency of the polymorphism in a group of 35 healthy controls.


CONCLUSIONS
The results from this study do not indicate that the TaqIB variation at the CETP gene locus is a significant predictor for assessing the risk of developing coronary restenosis following PTCA and stenting. This result was not affected when considering any one of the additionally studied factors.
Kaestner
Sabine
S
Department of Pharmacology, Patras University School of Medicine, Rio, Patras, Greece.
Patsouras
Nikolaos
N
Spathas
Dionysios H
DH
Flordellis
Christodoulos S
CS
Manolis
Antonis S
AS
D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D016022:Case-Control Studies; D053480:Cholesterol Ester Transfer Proteins / Q000235:genetics*; D015331:Cohort Studies; D003324:Coronary Artery Disease / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D023903:Coronary Restenosis / Q000235:genetics*; D015252:Deoxyribonucleases, Type II Site-Specific; D005260:Female; D006115:Greece; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D012150:Polymorphism, Restriction Fragment Length; D012307:Risk Factors; D015607:Stents
C506642:CETP protein, human; D053480:Cholesterol Ester Transfer Proteins; D015252:Deoxyribonucleases, Type II Site-Specific; C027046:TCGA-specific type II deoxyribonucleases