title: [Design and synthesis of 3'-methyl-furanonucleosides and their anti-tumor activities].
abstract: Taking 3'-Me-Ado (3'-methyladenosine) and Cladribine as the leading compounds, seventeen 3'-C-methyl-furanonucleosides were designed and synthesized. All the structures were confirmed by 1H NMR and MS. The target compounds were tested in vitro against human pulmonary carcinoma A549, human colon carcinoma LOVO and human leukemia CEM by MTT assay. The results showed that these compounds possessed moderate cytotoxicities.
authors.affiliation: State Key Laboratory of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, Shanghai 200437, China. shilihong6@hotmail.com
authors.forename: Li-Hong
authors.initials: LH
authors.lastname: Shi
authors.forename: Dong-Zhe
authors.initials: DZ
authors.lastname: Jin
authors.forename: Wei-Cheng
authors.initials: WC
authors.lastname: Zhou
authors.forename: Juan
authors.initials: J
authors.lastname: Wang
authors.forename: Xiu-Hua
authors.initials: XH
authors.lastname: Chen
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D017338:Cladribine / Q000138:chemical synthesis / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure
chemical_list: D000970:Antineoplastic Agents; D017338:Cladribine; C031080:3-methyladenosine; D000241:Adenosine