Effects of acute and chronic murine norovirus infections on immune responses and recovery from Friend retrovirus infection.
Murine norovirus (MNV) is a highly infectious but generally nonpathogenic agent that is commonly found in research mouse colonies in both North America and Europe. In the present study, the effects of acute and chronic infections with MNV on immune responses and recovery from concurrent Friend virus (FV) infections were investigated. No significant differences in T-cell or NK-cell responses, FV-neutralizing antibody responses, or long-term recovery from FV infection were observed. We conclude that concurrent MNV infections had no major impacts on FV infections.
Ammann
Christoph G
CG
Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases,National Institutes of Health, Hamilton, Montana 59840, USA.
Messer
Ronald J
RJ
Varvel
Kimberly
K
Debuysscher
Blair L
BL
Lacasse
Rachel A
RA
Pinto
Amelia K
AK
Hasenkrug
Kim J
KJ
D000208:Acute Disease; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D017250:Caliciviridae Infections / Q000276:immunology*; D002908:Chronic Disease; D005622:Friend murine leukemia virus; D007942:Leukemia, Experimental / Q000276:immunology*; D051379:Mice; D029322:Norovirus; D012192:Retroviridae Infections / Q000276:immunology*; D014412:Tumor Virus Infections / Q000276:immunology*
D000914:Antibodies, Viral