[Synthesis and in vitro cytotoxicity of naphthalimide polyamine conjugates as antitumor agents].
Six naphthalimide polyamine conjugates were synthesized and their structures were confirmed by elemental analysis, 1H NMR, 13C NMR and MS. Antitumor activities were evaluated in vitro using MTT assay on Leukemia cells (K562), human breast cancer cells (MB-231) and prostate cancer cells (Ln cap cell). The results showed that most of the six compounds were superior to the control (amonafide), 6d, 6e, and 6f exhibited nice selectivity in a screen of hepatoma cells (BEL-7402) and human normal hepatocytes (QSG-7701).
Mei
Zi-Hou
ZH
Key Laboratory of Natural Products and Immune Engineering, College of Chemistry and Techonology, Henan University, Kaifeng 475001, China.
Tian
Zhi-Yong
ZY
Ma
Hong-Xia
HX
Xie
Song-Qiang
SQ
Zhao
Jin
J
Wang
Chao-Jie
CJ
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D045744:Cell Line, Tumor / Q000187:drug effects; D006801:Humans; D008297:Male; D015394:Molecular Structure; D053644:Naphthalimides / Q000138:chemical synthesis* / Q000494:pharmacology*; D011073:Polyamines / Q000138:chemical synthesis / Q000494:pharmacology
D000970:Antineoplastic Agents; D053644:Naphthalimides; D011073:Polyamines