Binge drinking aggravates the outcomes of first-attack severe acute pancreatitis.
OBJECTIVE
To study the association of binge drinking and the outcomes of severe acute pancreatitis (SAP).


METHODS
This retrospective study included 347 patients with first-attack SAP from January 2001 to February 2004. On the basis of the history of binge drinking or not, the patients were divided into the alcohol (n = 77) and the control groups (n = 270). Clinical data of the 2 groups were compared.


RESULTS
Patient age and comorbidity were similar between the 2 groups. There were more men (64, 83.1%) than women (13, 16.9%; P < 0.05) in the alcohol and the control groups (111, 41.1%; P < 0.05). The 2 groups had significant differences in admission serum triglyceride levels (5.0 +/- 5.0 vs 3.0 +/- 3.5, P < 0.05), Balthazar computed tomographic score (6.3 +/- 5.4 vs 4.2 +/- 4.5, P < 0.05), and Acute Physiology and Chronic Heath Evaluation II score (19.1 +/- 5.1 vs 16.2 +/- 6.0, P < 0.05). Total mortality and the incidences of complications were higher in the alcohol group than in the control group (P < 0.05).


CONCLUSIONS
Binge drinking might be a contributor to the aggravation of first-attack SAP.
Deng
Lihui
L
Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu, People's Republic of China.
Xue
Ping
P
Huang
Lei
L
Yang
Xiaonan
X
Wan
Meihua
M
Xia
Qing
Q
D018806:APACHE; D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000428:Alcohol Drinking / Q000009:adverse effects* / Q000401:mortality; D000681:Amylases / Q000097:blood; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002492:Central Nervous System Depressants / Q000009:adverse effects*; D016009:Chi-Square Distribution; D002648:Child; D000431:Ethanol / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008049:Lipase / Q000097:blood; D008297:Male; D008875:Middle Aged; D019512:Pancreatitis, Alcoholic / Q000097:blood / Q000175:diagnosis / Q000209:etiology* / Q000401:mortality / Q000628:therapy; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D012720:Severity of Illness Index; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
D015415:Biomarkers; D002492:Central Nervous System Depressants; D014280:Triglycerides; D000431:Ethanol; D008049:Lipase; D000681:Amylases