title: Added sampling improves reproducibility of multipoint motor unit estimates.
abstract: Motor unit number estimation (MUNE) has been used to track motor unit attrition. Studies have used the modified multiple-point stimulation (MPS) technique, collecting three surface motor unit action potentials (sMUAPs) from 3 sites to calculate MUNE. Factoring additional sMUAPs should theoretically improve reproducibility, but the optimal number has not been defined. We evaluated the effect of increased sMUAP sampling on test-retest reproducibility of the modified MPS MUNE technique and found that MUNE reproducibility increased with additional sampling. Muscle Nerve, 2010.
authors.affiliation: Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 165 Cambridge Street, Suite 820, Boston, Massachusetts 02114, USA. nagoyal@partners.org
authors.forename: Namita
authors.initials: N
authors.lastname: Goyal
authors.forename: Johnny S
authors.initials: JS
authors.lastname: Salameh
authors.forename: Laura E
authors.initials: LE
authors.lastname: Baldassari
authors.forename: William S
authors.initials: WS
authors.lastname: David
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D004558:Electric Stimulation; D004576:Electromyography / Q000379:methods*; D019054:Evoked Potentials, Motor / Q000502:physiology; D005500:Follow-Up Studies; D006801:Humans; D009046:Motor Neurons / Q000502:physiology*; D018482:Muscle, Skeletal / Q000294:innervation* / Q000503:physiopathology; D012016:Reference Values; D015203:Reproducibility of Results; D020424:Ulnar Neuropathies / Q000175:diagnosis* / Q000503:physiopathology