Environmental toxicogenomics: a post-genomic approach to analysing biological responses to environmental toxins.
Environmental genomics has revolutionised how researchers can study the molecular basis of adverse effects of environmental toxicants. It is expected that the new discipline will afford efficient and high-throughput means to delineate mechanisms of action, risk assessment, identify and understand basic pathogenic mechanisms that are critical to disease progression, predict toxicity of unknown agents and to more precisely phenotype disease subtypes. Previously, we have demonstrated the potential of environmental genomics in a toxicant exposure model and, perhaps, this might become a crucial tool in biological response marker or biomarker discovery. To illustrate how toxicogenomics can be useful, we provide here an overview of some of the past and potential future aspects of environmental genomics. The present article also reviews the principles and technological concerns, and the standards and databases of toxicogenomics. In addition, applications of toxicogenomics in drug target identifications and validation strategies are also discussed.
Jayapal
Manikandan
M
Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, 2 Medical Drive, Singapore 117597, Singapore.
Bhattacharjee
Rabindra N
RN
Melendez
Alirio J
AJ
Hande
M Prakash
MP
D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D016208:Databases, Factual; D004777:Environment; D053263:Gene Regulatory Networks; D023281:Genomics; D006801:Humans; D043922:Toxicogenetics / Q000379:methods*
D015415:Biomarkers