[Renin-aldosterone system in patients with hypertensive form of chronic glomerulonephritis and preserved renal function].
The state of the renin-aldosterone system in 100 patients with hypertonic form of chronic glomerulonephritis (CGN) with the preserved renal function was assessed by RIA. The control group comprised 35 patients with CGH without arterial hypertension (AH). The study showed that plasma active renin (PAR) and aldosterone (PAL) levels remained unaltered in normotensive CGN patients with the preserved renal function but tended to increase in patients with AH. PAR levels correlated with the severity of AH. The PAL level was significantly elevated in CGN patients with grade II and III AH. Results of the study suggest an important role of elevated PAR levels in the development of AH in patients with CGN and preserved renal function. Moreover, such patients show a tendency toward a rise in their PAL level.
Borovkova
N Iu
NIu
Borovkov
N N
NN
Sidnev
B N
BN
D000450:Aldosterone / Q000097:blood*; D001794:Blood Pressure / Q000502:physiology; D002908:Chronic Disease; D005919:Glomerular Filtration Rate / Q000502:physiology*; D005921:Glomerulonephritis / Q000150:complications / Q000378:metabolism* / Q000503:physiopathology; D006801:Humans; D006977:Hypertension, Renal / Q000209:etiology / Q000378:metabolism* / Q000503:physiopathology; D011379:Prognosis; D012083:Renin / Q000097:blood*; D012084:Renin-Angiotensin System / Q000502:physiology*; D012720:Severity of Illness Index
D000450:Aldosterone; D012083:Renin