title: Droplet-based compartmentalization of chemically separated components in two-dimensional separations.
abstract: We demonstrate that nanolitre-sized droplets are an effective tool in coupling two-dimensional separations in both time and space. Using a microfluidic droplet connector, chemically separated components can be segmented into nanolitre droplets. After oil filtering and droplet merging, these droplets are loaded into a second dimension for comprehensive separations.
authors.affiliation: Department of Chemistry, Imperial College London, South Kensington, London, UK SW7 2AZ.
authors.forename: X Z
authors.initials: XZ
authors.lastname: Niu
authors.forename: B
authors.initials: B
authors.lastname: Zhang
authors.forename: R T
authors.initials: RT
authors.lastname: Marszalek
authors.forename: O
authors.initials: O
authors.lastname: Ces
authors.forename: J B
authors.initials: JB
authors.lastname: Edel
authors.forename: D R
authors.initials: DR
authors.lastname: Klug
authors.forename: A J
authors.initials: AJ
authors.lastname: deMello
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000295:instrumentation*; D019075:Electrophoresis, Capillary / Q000295:instrumentation*; D004867:Equipment Design; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation*; D010455:Peptides / Q000302:isolation & purification*
chemical_list: D010455:Peptides