title: Myasthenia gravis and autoimmune Addison disease in a patient with thymoma.
abstract: The association of thymoma with myasthenia gravis has been well documented. However, the relationship between these two syndromes and Addison disease are very rarely encountered in clinical practice. We report on a 32-year-old man who underwent a resection for thymoma 48 months ago. The diagnosis of Addison disease was made followed by a diagnosis of myasthenia gravis on the basis of a high titer of acetylcholine receptor levels. The treatment of oral prednisolone 7.5 mg/day and oral prostigmine 180 mg/day was initiated. His symptoms and physical signs were improved after this treatment. To our knowledge, this is the fourth reported case of thymoma synchronously associated with myasthenia gravis and Addison disease.
authors.affiliation: Department of Medical Oncology, Dr. Lutfi Kirdar Kartal Education and Research Hospital, Istanbul, Turkey. mnseker@hotmail.com
authors.forename: Mesut
authors.initials: M
authors.lastname: Seker
authors.forename: Hulya Iliksu
authors.initials: HI
authors.lastname: Gozu
authors.forename: Bala Basak
authors.initials: BB
authors.lastname: Oven Ustaalioğlu
authors.forename: Berkant
authors.initials: B
authors.lastname: Sonmez
authors.forename: Fatih Yavuz
authors.initials: FY
authors.lastname: Erkal
authors.forename: Mihriban
authors.initials: M
authors.lastname: Kocak
authors.forename: Nagehan Ozdemir
authors.initials: NO
authors.lastname: Barisik
authors.forename: Ekrem
authors.initials: E
authors.lastname: Orbay
authors.forename: Mehmet
authors.initials: M
authors.lastname: Sargin
authors.forename: Haluk
authors.initials: H
authors.lastname: Sargin
authors.forename: Ulku Turk
authors.initials: UT
authors.lastname: Boru
authors.forename: Mustafa
authors.initials: M
authors.lastname: Yaylaci
mesh_terms: D000109:Acetylcholine / Q000378:metabolism*; D000224:Addison Disease / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D000284:Administration, Oral; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage; D002800:Cholinesterase Inhibitors / Q000008:administration & dosage; D006801:Humans; D008297:Male; D009157:Myasthenia Gravis / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D009388:Neostigmine / Q000008:administration & dosage; D011239:Prednisolone / Q000008:administration & dosage; D011950:Receptors, Cholinergic / Q000096:biosynthesis / Q000097:blood / Q000235:genetics; D013945:Thymoma / Q000150:complications* / Q000276:immunology / Q000503:physiopathology / Q000601:surgery*; D013953:Thymus Neoplasms / Q000150:complications* / Q000276:immunology / Q000601:surgery*
chemical_list: D000893:Anti-Inflammatory Agents; D018931:Antineoplastic Agents, Hormonal; D002800:Cholinesterase Inhibitors; D011950:Receptors, Cholinergic; D009388:Neostigmine; D011239:Prednisolone; D000109:Acetylcholine