Anticancer activity of an Indian medicinal plant, Alstonia scholaris, on skin carcinogenesis in mice.
Alstonia scholaris, commonly known as sapthaparna, has been used for centuries in Ayurvedic medicine for treatment of various disorders. The objective of this study was to investigate the possible chemopreventive and anti-oxidative properties of this medicinal plant on two-stage process of skin carcinogenesis induced by a single application of 7, 12-dimethyabenz(a)anthrecene (100 lg/100 ll acetone), and two weeks later, promoted by repeated application of croton oil (1% in acetone/thrice a week) till the end of the experiment (16 weeks) in Swiss albino mice.The tumor incidence, tumor yield, tumor burden and cumulative number of papillomas were found to be higher in the carcinogen treated control (without ASE treatment) as compared to experimental animals (ASE treated). Furthermore, a significant increase in reduced glutathione, superoxide dismutase and catalase but decrease in lipid peroxidation was measured in ASE administered experimental groups than the carcinogen treated control. The present study demonstrates the chemopreventive potential of Alstonia scholaris bark extract in DMBA-induced skin tumorigenesis in Swiss albino mice.
Jahan
Swafiya
S
University of Rajasthan, Jaipur, India.
Chaudhary
Ranu
R
Goyal
Pradeep Kumar
PK
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000494:pharmacology; D031051:Alstonia / Q000737:chemistry*; D000818:Animals; D002374:Catalase / Q000378:metabolism; D018890:Chemoprevention / Q000379:methods; D003436:Croton Oil / Q000494:pharmacology; D005978:Glutathione / Q000097:blood / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D010212:Papilloma / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control; D024301:Plant Bark / Q000737:chemistry*; D010936:Plant Extracts / Q000008:administration & dosage / Q000627:therapeutic use*; D012867:Skin / Q000378:metabolism / Q000473:pathology; D012878:Skin Neoplasms / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D013482:Superoxide Dismutase / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
D010936:Plant Extracts; D017392:Thiobarbituric Acid Reactive Substances; D015127:9,10-Dimethyl-1,2-benzanthracene; D003436:Croton Oil; D002374:Catalase; D013482:Superoxide Dismutase; D005978:Glutathione