Ocotea quixos Lam. essential oil: in vitro and in vivo investigation on its anti-inflammatory properties.
Here we investigated the anti-inflammatory properties of Ocotea quixos essential oil and of its main components, trans-cinnamaldehyde and methyl cinnamate, in in vitro and in vivo models. Ocotea essential oil and trans-cinnamaldehyde but not methyl cinnamate significantly reduced LPS-induced NO release from J774 macrophages at non-toxic concentrations, inhibited LPS-induced COX-2 expression and increased forskolin-induced cAMP production. The essential oil (30-100mg/kg os) and trans-cinnamaldehyde (10mg/kg os) in carrageenan-induced rat paw edema showed anti-inflammatory effect without damaging gastric mucosa. In conclusion we provide the first evidence of a significant anti-inflammatory gastro-sparing activity of O.quixos essential oil.
Ballabeni
Vigilio
V
Department of Pharmacological, Biological and Chemical Applied Sciences, University of Parma, Via GP Usberti 27/a, 43100 Parma, Italy.
Tognolini
Massimiliano
M
Giorgio
Carmine
C
Bertoni
Simona
S
Bruni
Renato
R
Barocelli
Elisabetta
E
D000171:Acrolein / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D002351:Carrageenan; D045744:Cell Line, Tumor; D002934:Cinnamates; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D005753:Gastric Mucosa / Q000187:drug effects; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism*; D008070:Lipopolysaccharides; D008264:Macrophages / Q000187:drug effects; D008297:Male; D009447:Neuroblastoma / Q000188:drug therapy; D027444:Ocotea / Q000737:chemistry*; D009822:Oils, Volatile / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
D000893:Anti-Inflammatory Agents; D000972:Antineoplastic Agents, Phytogenic; D002934:Cinnamates; D018836:Inflammation Mediators; D008070:Lipopolysaccharides; D009822:Oils, Volatile; D010936:Plant Extracts; C025385:methyl cinnamate; D000171:Acrolein; D002351:Carrageenan; C012843:cinnamaldehyde