Cytotoxic activity of a flavanone from the stem of Bauhinia variegata Linn.
A flavanone has been isolated first time from the stem of Bauhinia variegata, and its structure was identified by colour reactions and spectral analysis. In a search for novel anticancer compounds from medicinal plants, the isolated flavanone was tested for cytotoxic activity against 57 human tumour lines, representing leukaemia, non-small cell lung, colon, central nervous system, melanoma, ovarian, renal, prostate and breast cancers. The results showed that the flavanone has cytotoxic activity against human tumour cell lines.
Rajkapoor
Balasubramanian
B
Department of Pharmacology, St. John's Pharmacy College, Bangalore, India. rajkapoorb1975@yahoo.com
Murugesh
Narayanan
N
Rama Krishna
Devarakonda
D
D036481:Bauhinia / Q000737:chemistry*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D044950:Flavanones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D018547:Plant Stems / Q000737:chemistry*
D044950:Flavanones; C028610:flavanone