NeoPHOX--an easily accessible P,N-ligand for iridium-catalyzed asymmetric hydrogenation: preparation, scope and application in the synthesis of demethyl methoxycalamenene.
Using a new class of chiral iridium hydrogenation catalysts, the antitumor natural product demethyl calamenene was synthesized in four steps in >20% overall yield and high enantiomeric purity.
Schrems
Marcus G
MG
Department of Chemistry, University of Basel, St. Johanns-Ring 19, CH-4056 Basel, Switzerland.
Pfaltz
Andreas
A
D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D002384:Catalysis; D006865:Hydrogenation; D007495:Iridium / Q000737:chemistry*; D008024:Ligands; D013729:Terpenes / Q000138:chemical synthesis*
D000970:Antineoplastic Agents; D008024:Ligands; D013729:Terpenes; C546737:demethyl methoxycalamenene; D007495:Iridium