title: [Evidence versus experience in neonatal practice: the example of extremely premature infants].
abstract: We focused on current nutritional and ventilation strategies of extremely preterm infants and reviewed the evidence and the practical experience in four French neonatal intensive care units. The recommendations from reviews and the local clinical guidelines were compared and were overall in agreement. We wanted then to evaluate if different ventilatory and nutritional styles existed between four French intensive neonatal units, and if these approaches had an effect on short term outcomes. 399 infants delivered at a gestational age <28 weeks between January 2005 and December 2006 were retrospectively studied (unit I = 141, unit II = 97, unit III = 85, unit IV = 76). Data were collected from birth to discharge. The study groups were similar with regard to gestational age, birth weight, gender, prenatal steroids, rate of inborn. There were significant differences in ventilatory and nutritional strategies between the units. Incidence of NEC, IVH grade 3-4 and PVL were similar between the units. Mortality rate during the hospitalization stay was 14.9 %, 35.0 %, 29.4 % and 29 % (p<0.05). A national database would be useful to analyse differences in strategies and long term outcomes.
authors.affiliation: Service de réanimation mixte et polyvalente, Hôpital des enfants, Toulouse, Hôpital des enfants, Toulouse, France. marcoux.mo@chu-toulouse.fr
authors.forename: M-O
authors.initials: MO
authors.lastname: Marcoux
authors.forename: S
authors.initials: S
authors.lastname: Denizot
authors.forename: G
authors.initials: G
authors.lastname: Dassieu
authors.forename: J-C
authors.initials: JC
authors.lastname: Picaud
authors.forename: C
authors.initials: C
authors.lastname: Cristini
authors.forename: C
authors.initials: C
authors.lastname: Arnaud
authors.forename: N
authors.initials: N
authors.lastname: Montjaux
authors.forename: S
authors.initials: S
authors.lastname: Bonnet
authors.forename: J-C
authors.initials: JC
authors.lastname: Rozé
authors.forename: C
authors.initials: C
authors.lastname: Danan
authors.forename: M-C
authors.initials: MC
authors.lastname: Bloom
authors.forename: C
authors.initials: C
authors.lastname: Casper
mesh_terms: D001724:Birth Weight; D053198:Child Nutrition Sciences; D005260:Female; D005328:Fetal Viability; D005602:France; D005865:Gestational Age; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007363:Intensive Care Units, Neonatal / Q000592:standards*; D007902:Length of Stay; D008297:Male; D018743:Perinatal Care / Q000592:standards*; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D016896:Treatment Outcome