title: Phytochemical mediated gold nanoparticles and their PTP 1B inhibitory activity.
abstract: Current discovery demonstrates the rapid formation of gold nanoparticles with guavanoic acid a phytochemical of Psidium guajava (Pg). The pharmacological capabilities of the phytochemicals present in the leaves of Pg and their ability to generate gold nanoparticles is presented herein. The new genre of green nanoparticles exhibit remarkable Protein Tyrosine Phosphatase 1B (PTP 1B) inhibitory activity and in vitro stability in various physiological medium including saline, histidine, cysteine, bovine serum albumin (BSA), human serum albumin (HSA) and buffers (pH 5, 7 and 9). It is predicted that this new technology will be felt greatly in several routes of pharmaceuticals.
authors.affiliation: Department of Zoology, Thiruvalluvar University, Fort Campus, Vellore Fort, Vellore 632004, Tamil Nadu, India.
authors.forename: Sabjan
authors.initials: S
authors.lastname: Khaleel Basha
authors.forename: Kasivelu
authors.initials: K
authors.lastname: Govindaraju
authors.forename: Ramar
authors.initials: R
authors.lastname: Manikandan
authors.forename: Jong Seog
authors.initials: JS
authors.lastname: Ahn
authors.forename: Eun Young
authors.initials: EY
authors.lastname: Bae
authors.forename: Ganesan
authors.initials: G
authors.lastname: Singaravelu
mesh_terms: D002712:Chlorides / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006046:Gold / Q000494:pharmacology*; D017612:Gold Compounds / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1 / Q000037:antagonists & inhibitors*; D031647:Psidium / Q000737:chemistry*; D012996:Solutions; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D013997:Time Factors; D014315:Triterpenes / Q000494:pharmacology*; D014961:X-Ray Diffraction
chemical_list: D002712:Chlorides; D004791:Enzyme Inhibitors; D017612:Gold Compounds; D012996:Solutions; D014315:Triterpenes; C473526:guavanoic acid; D006046:Gold; C024568:gold tetrachloride, acid; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1