Implication of HIC1 (Hypermethylated In Cancer 1) in the DNA damage response.
HIC1 (Hypermethylated In Cancer 1) is a tumor suppressor gene which is epigenetically inactivated in many human cancers. HIC1 encodes a transcriptional repressor comprising an N-terminal BTB/POZ domain and a C-terminal DNA binding domain containing five Krüppel-like C(2)H(2) zinc fingers. To date, few HIC1 target genes are known and the regulation of HIC1 activity is not fully deciphered. However, a growing list of studies, summarized in this review, strongly suggest that HIC1 plays a central role in the DNA damage response through the establishment of several complex regulatory loops involving HIC1, p53, SIRT1 and E2F1.
Dehennaut
Vanessa
V
CNRS-UMR 8161, Institut de Biologie de Lille, Université de Lille-Nord de France, Institut Pasteur de Lille, IFR 142, 1, rue Calmette, BP447, 59017, Lille Cedex, France. vanessa.dehennaut@ibl.fr
Leprince
Dominique
D
D004249:DNA Damage / Q000235:genetics / Q000502:physiology*; D004260:DNA Repair / Q000235:genetics / Q000502:physiology*; D050687:E2F1 Transcription Factor / Q000235:genetics / Q000502:physiology*; D020868:Gene Silencing; D006801:Humans; D051741:Kruppel-Like Transcription Factors / Q000235:genetics / Q000502:physiology*; D012097:Repressor Proteins / Q000235:genetics / Q000502:physiology; D056564:Sirtuin 1 / Q000502:physiology*; D014158:Transcription, Genetic / Q000502:physiology; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000502:physiology*
D050687:E2F1 Transcription Factor; C493753:E2F1 protein, human; C499808:HIC1 protein, human; D051741:Kruppel-Like Transcription Factors; D012097:Repressor Proteins; D016159:Tumor Suppressor Protein p53; C447939:SIRT1 protein, human; D056564:Sirtuin 1