title: Design and synthesis of a simplified inhibitor for XIAP-BIR3 domain.
abstract: Based on tetrapeptide AVPI, we were able to design and synthesize a new simplified scaffold to inhibit the BIR3 domain of the XIAP protein at low micromolar range. The uncomplicated synthesis and the binding activity of the molecule disclosed here represent an attractive alternative to develop new compounds targeting the protein-protein interaction of XIAP/caspase9.
authors.affiliation: The Burnham Institute for Medical Research, 10901 N. Torrey Pines Rd., La Jolla, CA 92037, USA.
authors.forename: Fernando R Pinacho
authors.initials: FR
authors.lastname: Crisóstomo
authors.forename: Yongmei
authors.initials: Y
authors.lastname: Feng
authors.forename: Xuejun
authors.initials: X
authors.lastname: Zhu
authors.forename: Kate
authors.initials: K
authors.lastname: Welsh
authors.forename: Jing
authors.initials: J
authors.lastname: An
authors.forename: John C
authors.initials: JC
authors.lastname: Reed
authors.forename: Ziwei
authors.initials: Z
authors.lastname: Huang
mesh_terms: D017209:Apoptosis; D018360:Crystallography, X-Ray; D015195:Drug Design; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins; D024101:Mitochondrial Proteins; D009842:Oligopeptides / Q000737:chemistry*; D011487:Protein Conformation; D017434:Protein Structure, Tertiary; D013329:Structure-Activity Relationship; D051636:X-Linked Inhibitor of Apoptosis Protein / Q000008:administration & dosage* / Q000037:antagonists & inhibitors
chemical_list: D051034:Inhibitor of Apoptosis Proteins; D024101:Mitochondrial Proteins; D009842:Oligopeptides; D051636:X-Linked Inhibitor of Apoptosis Protein; C496866:XIAP protein, human