title: Serum levels of CXCL13 are elevated in active multiple sclerosis.
abstract: There is increasing recognition of the important role that B cells play in the pathogenesis of multiple sclerosis (MS). Recently it was reported that the B cell chemokine CXCL13 is elevated in MS serum and cerebrospinal fluid. Here we study whether serum levels of CXCL13 are associated with active MS. We measured serum levels of CXCL13 by enzyme-linked immunosorbent assay in 74 patients with relapsing MS randomized to interferon beta 1b or glatiramer acetate and examined with monthly 3 T brain MRI scans optimized for detection of gadolinium-enhancement for up to 2 years. The median (range) serum levels of CXCL13 pre-treatment were 40 (3-171) pg/ml. Serum levels of CXCL13 were significantly higher at times of active brain MRI scans (p < 0.01). Furthermore, serum levels were higher in patients who never reached MRI remission compared with those in complete (p < 0.01) or partial (p = 0.01) remission. There was a significant positive correlation between the pattern of serum levels of CXCL13 and MRI activity during the first (r = 0.33, p < 0.05) and the full 2 years (r = 0.35, p < 0.01) of the study. Treatment with interferon beta 1b or glatiramer acetate did not affect serum CXCL13. We conclude that the serum levels of the B cell chemokine CXCL13 are associated with active MS.
authors.affiliation: UMDNJ-New Jersey Medical School, Newark, NJ, USA.
authors.forename: Eugene D
authors.initials: ED
authors.lastname: Festa
authors.forename: Karolina
authors.initials: K
authors.lastname: Hankiewicz
authors.forename: Soyeon
authors.initials: S
authors.lastname: Kim
authors.forename: Joan
authors.initials: J
authors.lastname: Skurnick
authors.forename: Leo J
authors.initials: LJ
authors.lastname: Wolansky
authors.forename: Stuart D
authors.initials: SD
authors.lastname: Cook
authors.forename: Diego
authors.initials: D
authors.lastname: Cadavid
mesh_terms: D000293:Adolescent; D000328:Adult; D001402:B-Lymphocytes / Q000378:metabolism; D001921:Brain / Q000473:pathology; D054382:Chemokine CXCL13 / Q000097:blood*; D004185:Disability Evaluation; D005260:Female; D000068717:Glatiramer Acetate; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007370:Interferon Type I / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood* / Q000175:diagnosis / Q000473:pathology; D009460:Neurologic Examination; D015588:Observer Variation; D010455:Peptides / Q000627:therapeutic use; D011994:Recombinant Proteins; D055815:Young Adult
chemical_list: D054382:Chemokine CXCL13; D007166:Immunosuppressive Agents; D007370:Interferon Type I; D010455:Peptides; D011994:Recombinant Proteins; D000068717:Glatiramer Acetate