title: Necrotising fasciitis of the extremity.
abstract: Necrotising fasciitis is a rare, life-threatening infection where there is necrosis of fascia, subcutaneous tissues and skin. Three adult patients presented with this condition affecting the extremities and all had predisposing medical factors. Each one complained of severe pain that seemed disproportionate to the skin affected. They underwent prompt surgical debridement and received antibiotic treatment and supportive therapy. These cases highlight the increasing incidence and differences in presentation of necrotising fasciitis, as well as the important symptom of pain. Patients can become moribund and require intensive care support. High mortality rates are well recognised.
authors.affiliation: Department of Plastic Surgery, Ninewells Hospital, Dundee, Scotland DD1 9SY, UK. liz.whallett@doctors.org.uk
authors.forename: E J
authors.initials: EJ
authors.lastname: Whallett
authors.forename: J H
authors.initials: JH
authors.lastname: Stevenson
authors.forename: A D
authors.initials: AD
authors.lastname: Wilmshurst
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D003646:Debridement / Q000379:methods*; D003937:Diagnosis, Differential; D019115:Fasciitis, Necrotizing / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D006225:Hand; D006801:Humans; D007710:Klebsiella Infections / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D007711:Klebsiella pneumoniae / Q000302:isolation & purification; D007866:Leg; D008297:Male; D008875:Middle Aged; D016038:Skin Transplantation / Q000379:methods*; D013290:Streptococcal Infections / Q000175:diagnosis / Q000209:etiology / Q000601:surgery; D013297:Streptococcus pyogenes / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents