title: Fibrinolytic therapy of prosthetic mitral valve thrombosis during pregnancy: three case reports and review of the literature.
abstract: The incidence of prosthetic valve thrombosis (PVT), which is a life-threatening complication, increased during pregnancy because of the hypercoagulable state. Despite adequate anticoagulation, the incidence of PVT has been estimated as 4% to 14% during pregnancy. Prosthetic valve thrombosis occurring during pregnancy requires urgent therapy including fibrinolytic therapy, valve replacement, and surgical thrombectomy due to high mortality. Although surgery has traditionally been the standard procedure for treatment of PVT, fibrinolytic therapy may be used as first-line therapy according to data from the recent reports. Data about the fibrinolytic therapy is scarce and controversial in the setting of pregnancies complicated with PVT. Herein, we share the outcomes of 3 pregnant women complicated with PVT and treated with recombinant tissue-type plasminogen activator.
authors.affiliation: Department of Cardiology, School of Medicine, Gaziantep University, Turkey. oozer@gantep.edu.tr
authors.forename: Orhan
authors.initials: O
authors.lastname: Ozer
authors.forename: Vedat
authors.initials: V
authors.lastname: Davutoglu
authors.forename: Hatice E
authors.initials: HE
authors.lastname: Soydinc
authors.forename: Fatma B
authors.initials: FB
authors.lastname: Cebesoy
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Sari
authors.forename: Murat
authors.initials: M
authors.lastname: Akcay
mesh_terms: D003328:Coronary Thrombosis / Q000000981:diagnostic imaging / Q000188:drug therapy*; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006349:Heart Valve Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy*; D006350:Heart Valve Prosthesis / Q000009:adverse effects*; D006801:Humans; D008943:Mitral Valve / Q000000981:diagnostic imaging / Q000601:surgery*; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000097:blood / Q000000981:diagnostic imaging / Q000601:surgery*; D015912:Thrombolytic Therapy / Q000379:methods*; D014463:Ultrasonography; D055815:Young Adult
chemical_list: D005343:Fibrinolytic Agents