title: [Expression and role of peroxisome proliferator-activated receptor gamma and nuclear factor-kappaB in pulmonary fibrosis].
abstract: OBJECTIVE
  To evaluate the expression of peroxisome proliferator-activated receptor gamma (PPARgamma) and nuclear factor-kappaB (NF-kappaB) in lungs in patients with pulmonary fibrosis, and to explore their effect on the pathogenesis of pulmonary fibrosis.
  
  
  METHODS
  Immunohistochemical technology was performed to investigate the PPARgamma and NF-kappaB expression in lung specimens from 16 cases of pulmonary fibrosis and 10 cases of normal controls.
  
  
  RESULTS
  The positive score of PPARgamma (0.35+/- 0.08) in fibrosis group was lower than that in control group (0.42+/-0.04, P<0.05). The positive score of NF-kappaB (0.51+/- 0.11) in fibrosis group was higher than that in control group (0.38+/-0.04, P<0.05). There was negative correlation between PPARgamma and NF-kappaB expression in fibrosis group (P<0.05).
  
  
  CONCLUSIONS
  The decreased expression of PPARgamma and enhanced expression of NF-kappaB play a role in the pathogenesis of pulmonary fibrosis, which may provide a new idea for treating this disease.
authors.affiliation: Department Geriatrics, Peking University First Hospital, Beijing 100034, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Lin
authors.forename: Lian Fang
authors.initials: LF
authors.lastname: Ni
authors.forename: Ya Li
authors.initials: YL
authors.lastname: Ren
authors.forename: Xin Min
authors.initials: XM
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D016328:NF-kappa B / Q000378:metabolism*; D047495:PPAR gamma / Q000378:metabolism*; D011658:Pulmonary Fibrosis / Q000378:metabolism*
chemical_list: D016328:NF-kappa B; D047495:PPAR gamma