Cadherins as novel targets for anti-cancer therapy.
The cell adhesion molecules N-, VE- and OB-cadherin have been implicated as regulators of tumor growth and metastasis. We discuss evidence that N- and VE-cadherin play a key role in promoting blood vessel formation and stability, processes which are essential for tumor growth. Secondly, we describe the potential involvement of N- and OB-cadherin in the metastatic process. Finally, studies concerning the effects of the N-cadherin antagonist designated ADH-1 on tumor growth are presented. Collectively, these observations suggest that antagonists of N-, VE- and OB-cadherin would be useful as anti-cancer agents.
Blaschuk
Orest W
OW
Division of Urology, Department of Surgery, McGill University, Urology Research Laboratories, Royal Victoria Hospital, Room H6.15, 687 Pine Avenue West, Montreal, Quebec, Canada H3A 1A1. orest.blaschuk@mcgill.ca
Devemy
Emmanuelle
E
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D015820:Cadherins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D002448:Cell Adhesion / Q000187:drug effects; D002986:Clinical Trials as Topic; D016503:Drug Delivery Systems; D006801:Humans; D009362:Neoplasm Metastasis / Q000473:pathology; D009369:Neoplasms / Q000188:drug therapy* / Q000503:physiopathology; D010456:Peptides, Cyclic / Q000494:pharmacology
D000970:Antineoplastic Agents; D015820:Cadherins; C541294:N-Ac-CHAVC-NH2; D010456:Peptides, Cyclic