Conduction block of peripheral nerve using high-frequency alternating currents delivered through an intrafascicular electrode.
Many diseases are characterized by undesired or pathological neural activity. The local delivery of high-frequency currents has been shown to be an effective method for blocking neural conduction in peripheral nerves and may provide a therapy for these conditions. To date, all studies of high-frequency conduction block have utilized extraneural (cuff) electrodes to achieve conduction block. In this study we show that high-frequency conduction block is feasible using intrafascicular electrodes.
Ackermann
D Michael
DM
Case Western Reserve University, Cleveland, Ohio, USA.
Foldes
Emily L
EL
Bhadra
Niloy
N
Kilgore
Kevin L
KL
D000200:Action Potentials / Q000502:physiology; D000818:Animals; D004195:Disease Models, Animal; D004558:Electric Stimulation / Q000379:methods*; D004566:Electrodes; D018482:Muscle, Skeletal / Q000294:innervation* / Q000503:physiopathology; D009407:Nerve Block / Q000379:methods*; D009431:Neural Conduction / Q000502:physiology*; D010525:Peripheral Nerves / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley