title: Lack of advantage of high-fibre, moderate-carbohydrate diets in dogs with stabilised diabetes.
abstract: OBJECTIVE
  To assess the influence of high-fibre, moderate-carbohydrate diets with two levels of dietary fat, compared with a commercial diet with moderate-fibre, low-carbohydrate and higher fat, on insulin requirement, glycaemic control and lipid profile of dogs with stabilised diabetes.
  
  
  METHODS
  Twelve dogs with spontaneous diabetes mellitus were studied. Glycaemic control was evaluated by plasma fructosamine, glycosylated haemoglobin and 48-hour serial blood glucose measurements. The insulin dosage required to maintain clinical stability was also determined. Lipid profiles comprised serial measurements of plasma cholesterol, triglyceride, free glycerol and free fatty acids. Data were analysed using analysis of variance.
  
  
  RESULTS
  There were no significant differences in insulin requirement or glycaemic control among diets. Weight loss occurred when the dogs were fed the high-fibre, moderate-carbohydrate, moderate-fat diet (P<0.002), whereas weight was maintained with the other two diets. The high-fibre, moderate-carbohydrate, moderate-fat diet resulted in lower mean plasma cholesterol compared with either of the higher-fat diets (P< or =0.003), and lower mean plasma triglyceride (P=0.060), free fatty acid (P<0.001) and free glycerol (P=0.015) than the commercial diet.
  
  
  CONCLUSIONS
  For stable diabetic dogs, high-fibre, moderate-carbohydrate diets offered no significant advantage compared with a commercial diet with moderate fibre and low carbohydrate. Diets with high fibre, moderate carbohydrate and moderate fat should not be routinely recommended for dogs with thin body condition.
authors.affiliation: Centre for Companion Animal Health, School of Veterinary Science, The University of Queensland, Brisbane, Australia.
authors.forename: L M
authors.initials: LM
authors.lastname: Fleeman
authors.forename: J S
authors.initials: JS
authors.lastname: Rand
authors.forename: P J
authors.initials: PJ
authors.lastname: Markwell
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D003920:Diabetes Mellitus / Q000178:diet therapy / Q000188:drug therapy / Q000662:veterinary*; D004040:Dietary Carbohydrates / Q000008:administration & dosage*; D004041:Dietary Fats / Q000008:administration & dosage*; D004043:Dietary Fiber / Q000008:administration & dosage*; D004283:Dog Diseases / Q000178:diet therapy* / Q000188:drug therapy; D004285:Dogs; D005260:Female; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007328:Insulin / Q000627:therapeutic use; D050356:Lipid Metabolism / Q000187:drug effects; D008297:Male; D016896:Treatment Outcome; D015431:Weight Loss
chemical_list: D001786:Blood Glucose; D004040:Dietary Carbohydrates; D004041:Dietary Fats; D004043:Dietary Fiber; D007004:Hypoglycemic Agents; D007328:Insulin