Eating twice for the sake of immunity: a phagocytic receptor that activates autophagy.
The mechanism by which the cell responds to invading pathogens is an area of intense research. Joubert et al. (2009) have found that the phagocytic receptor CD46 is able to activate autophagy through a tripartite interaction between itself, a scaffold protein GOPC, and the autophagy inducer complex of Beclin1-VPS34.
Shahnazari
Shahab
S
Cell Biology Program, Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.
Brumell
John H
JH
D048868:Adaptor Proteins, Signal Transducing; D051017:Apoptosis Regulatory Proteins / Q000378:metabolism; D001343:Autophagy; D000071186:Beclin-1; D002352:Carrier Proteins / Q000378:metabolism; D000077614:Golgi Matrix Proteins; D006801:Humans; D051916:Membrane Cofactor Protein / Q000276:immunology*; D008565:Membrane Proteins / Q000378:metabolism; D026901:Membrane Transport Proteins; D008954:Models, Biological; D010587:Phagocytosis; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D025941:Protein Interaction Mapping
D048868:Adaptor Proteins, Signal Transducing; D051017:Apoptosis Regulatory Proteins; D000071186:Beclin-1; D002352:Carrier Proteins; D000077614:Golgi Matrix Proteins; D051916:Membrane Cofactor Protein; D008565:Membrane Proteins; D026901:Membrane Transport Proteins; D019869:Phosphatidylinositol 3-Kinases; C491997:BECN1 protein, human; C497857:CD46 protein, human; C434484:GOPC protein, human