Functionalization of self-assembled hexa-peri-hexabenzocoronene fibers with peptides for bioprobing.
A novel water-soluble hexa-peri-hexabenzocoronene (HBC) derivative with peripheral functional groups, which facilitates a two-step assembly process in water that includes fiber formation via pi stacking and subsequent peptide probing via electrostatic interactions, is reported. In the first step, the HBC derivative self-assembles into water-soluble red-fluorescent fibers that serve as templates for further functionalization with biomolecules. In the second assembly step, the peripheral functional groups bind green-fluorescent fluorescein-conjugated peptides, leading to the formation of well-defined fibers that were visualized as dual-color fibers in double-fluorescence imaging.
Yin
Meizhen
M
State Key Laboratory of Chemical Resource Engineering, College of Materials Science and Engineering, Beijing University of Chemical Technology, 100029 Beijing, China. yinmz@yahoo.com
Shen
Jie
J
Pisula
Wojciech
W
Liang
Minghui
M
Zhi
Linjie
L
Müllen
Klaus
K
D000595:Amino Acid Sequence; D008856:Microscopy, Fluorescence; D015335:Molecular Probes / Q000138:chemical synthesis / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry* / Q000378:metabolism; D011083:Polycyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D012995:Solubility; D014867:Water / Q000737:chemistry
D015335:Molecular Probes; D010455:Peptides; D011083:Polycyclic Compounds; C507240:hexa-peri-hexabenzocoronene; D014867:Water