Direct activation of protein kinases by ubiquitin.
The inhibitor of kB kinase (IKK) complex, a critical positive regulator of nuclear factor kappaB (NF-kappaB) signaling and immune function, can be activated in vitro by polyubiquitin chains. The modification of signaling intermediates by polyubiquitin and their association with ubiquitin-binding domain-containing proteins within multimolecular signaling complexes therefore represent a potential mechanism for activation of IKK and NF-kappaB in vivo.
Baker
Rebecca
R
Department of Microbiology and Immunology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Ghosh
Sankar
S
D004789:Enzyme Activation; D006801:Humans; D051550:I-kappa B Kinase / Q000235:genetics / Q000378:metabolism*; D016328:NF-kappa B / Q000235:genetics / Q000378:metabolism; D025821:Polyubiquitin / Q000378:metabolism*; D015398:Signal Transduction
D016328:NF-kappa B; D025821:Polyubiquitin; D051550:I-kappa B Kinase