title: Oral rotavirus vaccines: how well will they work where they are needed most?
abstract: Rotavirus vaccines hold promise to decrease the burden of severe diarrhea in the poorest countries, where 85% of deaths due to rotavirus occur. However, the potency of live oral vaccines is lower in these challenging settings than in middle- and upper-income countries. Many hypotheses have been suggested to explain these differences that could provide clues to improve the ultimate success of these novel vaccines. Although introduction today of even moderately effective vaccines will decrease the morbidity and mortality associated with rotavirus in low-income settings, research is urgently needed to understand why these differences in efficacy occur and what could be done to improve vaccine performance to maximize the life-saving benefits of vaccination.
authors.affiliation: Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
authors.forename: Manish
authors.initials: M
authors.lastname: Patel
authors.forename: Andi L
authors.initials: AL
authors.lastname: Shane
authors.forename: Umesh D
authors.initials: UD
authors.lastname: Parashar
authors.forename: Baoming
authors.initials: B
authors.lastname: Jiang
authors.forename: Jon R
authors.initials: JR
authors.lastname: Gentsch
authors.forename: Roger I
authors.initials: RI
authors.lastname: Glass
mesh_terms: D000284:Administration, Oral; D000914:Antibodies, Viral / Q000097:blood; D001942:Breast Feeding; D019049:Developed Countries; D003906:Developing Countries; D006801:Humans; D007422:Intestines / Q000382:microbiology; D044342:Malnutrition / Q000150:complications; D012400:Rotavirus Infections / Q000453:epidemiology / Q000517:prevention & control*; D022243:Rotavirus Vaccines / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D022243:Rotavirus Vaccines