Preoperative erythrocyte sedimentation rate is an independent prognostic factor in Japanese patients with localized clear cell renal cell carcinoma.
BACKGROUND
Few studies have examined the prognostic significance of common laboratory variables in Japanese patients with localized clear cell renal cell carcinoma (CCRCC). We evaluate the prognostic significance of preoperative laboratory variables in Japanese patients with localized CCRCC.


METHODS
The study included 110 Japanese patients who were pathologically confirmed as nonmetastatic CCRCC (pT1-3 N0M0) after radical nephrectomy at our institution. We assessed the clinical (including laboratory measurements) and pathological findings, with the survival rates after surgery.


RESULTS
Tumor stage and erythrocyte sedimentation rate (ESR) were identified as significant independent prognostic factors of progression-free survival in multivariate analysis. As for the prognostic factors for disease-specific survival, tumor stage and ESR had prognostic significance both in univariate and multivariate analyses. When the analysis was limited to pT1, multivariate analysis showed that only ESR was an independent prognostic factor for disease-specific survival.


CONCLUSIONS
Preoperative ESR is an independent prognostic factor in Japanese patients with localized CCRCC, especially in patients with pT1.
Kawai
Yoshihisa
Y
Department of Urology, Graduate School of Medicine, Yamaguchi University, Ube, Yamaguchi, Japan.
Matsuyama
Hideyasu
H
Korenaga
Yoshihito
Y
Misumi
Taku
T
Eguchi
Satoshi
S
Hara
Tomohiko
T
Nagao
Kazuhiro
K
Ohmi
Chietaka
C
Sakano
Shigeru
S
Naito
Katsusuke
K
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001799:Blood Sedimentation; D002292:Carcinoma, Renal Cell / Q000097:blood* / Q000601:surgery; D005260:Female; D006801:Humans; D007564:Japan; D007680:Kidney Neoplasms / Q000097:blood* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011300:Preoperative Care; D011379:Prognosis