Concomitant progressive supranuclear palsy and multiple system atrophy: more than a simple twist of fate?
Progressive supranuclear palsy (PSP) and multiple system atrophy (MSA) are both rare neurodegenerative diseases. In the Queen Square Brain Bank, from 2001 to 2008, we received 120 cases of pathologically confirmed PSP and 36 of MSA, and one had concomitant PSP and MSA pathology. The clinical symptoms in this case were compatible with PSP and did not predict the dual pathology. The growing number of collective case reports, including the one reported here, might suggest an increased prevalence of concomitant PSP and MSA than what would be expected by chance.
Silveira-Moriyama
Laura
L
Reta Lila Weston Institute for Neurological Studies, UCL Institute of Neurology, London, UK.
González
Ana Marcos
AM
O'Sullivan
Sean S
SS
Williams
David R
DR
Massey
Luke
L
Parkkinen
Laura
L
Ahmed
Zeshan
Z
de Silva
Rohan
R
Chacón
Jose R
JR
Revesz
Tamas
T
Lees
Andrew J
AJ
Holton
Janice L
JL
D000368:Aged; D001253:Astrocytes / Q000378:metabolism / Q000473:pathology; D015415:Biomarkers / Q000378:metabolism; D001921:Brain / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D015897:Comorbidity; D018450:Disease Progression; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D002479:Inclusion Bodies / Q000378:metabolism / Q000473:pathology; D008403:Mass Screening; D019578:Multiple System Atrophy / Q000453:epidemiology* / Q000473:pathology* / Q000503:physiopathology; D009434:Neural Pathways / Q000378:metabolism / Q000473:pathology; D009474:Neurons / Q000378:metabolism / Q000473:pathology*; D009836:Oligodendroglia / Q000378:metabolism / Q000473:pathology; D010300:Parkinson Disease / Q000453:epidemiology / Q000473:pathology / Q000503:physiopathology; D015995:Prevalence; D012720:Severity of Illness Index; D013494:Supranuclear Palsy, Progressive / Q000453:epidemiology* / Q000473:pathology* / Q000503:physiopathology; D051844:alpha-Synuclein / Q000378:metabolism; D016875:tau Proteins / Q000378:metabolism
D015415:Biomarkers; D051844:alpha-Synuclein; D016875:tau Proteins