title: Oxidant stress in HIV-infected women from the Women's Interagency HIV Study.
abstract: BACKGROUND
  Oxidant stress contributes to the pathogenesis of multiple conditions and can be assessed by measuring plasma F(2)-isoprostane concentrations. We hypothesized that oxidant stress is associated with plasma homocysteine concentration and risk factors for atherosclerosis in HIV-infected women.
  
  
  METHODS
  We measured plasma F(2)-isoprostane concentrations in a cross-sectional study of 249 HIV-infected women attending the Bronx (NY, USA) site of the Women's Interagency HIV Study and assessed associations with plasma homocysteine concentration and other metabolic parameters by linear regression.
  
  
  RESULTS
  In multivariate analysis, hepatitis C virus (HCV) viraemia, waist circumference, homocysteine concentration and serum aspartate aminotransferase level were positively associated with log F(2)-isoprostane concentration (all P<0.005). There was a trend for an inverse association between log F(2)-isoprostane and CD4(+) T-cell percentage (P=0.06). Among women with HCV infection, the FIB-4 index, an indirect marker of liver fibrosis derived from routine laboratory tests, was positively associated with log F(2)-isoprostane concentration.
  
  
  CONCLUSIONS
  In this cross-sectional study of HIV-infected women, plasma F(2)-isoprostane concentration was positively associated with homocysteine concentration, as well as HCV infection, abdominal obesity and aspartate aminotransferase level.
authors.affiliation: Division of Infectious Diseases, Department of Medicine, Weill Cornell Medical College, New York, NY, USA. mag2005@med.cornell.edu
authors.forename: Marshall J
authors.initials: MJ
authors.lastname: Glesby
authors.forename: Donald R
authors.initials: DR
authors.lastname: Hoover
authors.forename: Farbod
authors.initials: F
authors.lastname: Raiszadeh
authors.forename: Irene
authors.initials: I
authors.lastname: Lee
authors.forename: Qiuhu
authors.initials: Q
authors.lastname: Shi
authors.forename: Ginger
authors.initials: G
authors.lastname: Milne
authors.forename: Stephanie C
authors.initials: SC
authors.lastname: Sanchez
authors.forename: Wei
authors.initials: W
authors.lastname: Gao
authors.forename: Robert C
authors.initials: RC
authors.lastname: Kaplan
authors.forename: Jason D
authors.initials: JD
authors.lastname: Morrow
authors.forename: Kathryn
authors.initials: K
authors.lastname: Anastos
mesh_terms: D000328:Adult; D050197:Atherosclerosis / Q000150:complications; D003430:Cross-Sectional Studies; D028441:F2-Isoprostanes / Q000378:metabolism; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000378:metabolism*; D006710:Homocysteine / Q000097:blood; D006801:Humans; D008875:Middle Aged; D016877:Oxidants; D018384:Oxidative Stress; D012307:Risk Factors
chemical_list: D028441:F2-Isoprostanes; D016877:Oxidants; D006710:Homocysteine