Preparation and antitubercular activity of lipophilic diamines and amino alcohols.
A series of diamines and amino alcohols derived from 1-dodecanol, 1-tetradecanol, 1,2-dodecanediol and 1,2-tetradecanediol were synthesized and tested for their antitubercular activity. Compounds 3, 8 and 9 were found to be the most active (MIC of 6.25 microg/mL). Nine other compounds displayed activity against Mycobacterium tuberculosis, with a MIC of 12.5 microg/mL.
Júnior
Celso O R
CO
Departamento de Química, Universidade Federal de Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil.
le Hyaric
Mireille
M
Costa
Cristiane F da
CF
Corrêa
Taís A
TA
Taveira
Aline F
AF
Araújo
Débora P
DP
Reis
Elaine F C
EF
Lourenço
Maria Cristina S
MC
Vicente
Felipe R C
FR
Almeida
Mauro V de
MV
D000605:Amino Alcohols / Q000138:chemical synthesis / Q000494:pharmacology*; D000995:Antitubercular Agents / Q000737:chemistry / Q000494:pharmacology*; D003959:Diamines / Q000138:chemical synthesis / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects*
D000605:Amino Alcohols; D000995:Antitubercular Agents; D003959:Diamines