Role of proteomic technologies in understanding risk of arterial thrombosis.
Arterial thrombosis is a pivotal event in the development of cardiovascular diseases. Plasma and cellular proteins have the potential to influence thrombus morphology and function. This review summarizes the latest studies to use proteomic technologies to characterize the cellular and plasma components involved in arterial thrombosis, with a view to understanding the pathogenesis and treatment of acute cardiovascular diseases. Proteomic approaches have been extensively used to profile the proteome of endothelial cells, leukocytes, vascular smooth muscle cells, platelets and plasma in the search for risk factors for cardiovascular disease; however, further work is required to validate the direct contribution of these proteins to arterial thrombosis.
Polkinghorne
Victoria R
VR
Division of Cardiovascular and Diabetes Research, Faculty of Medicine and Health, and the Multidisciplinary Cardiovacular Research Center, University of Leeds, UK.
Standeven
Kristina F
KF
Schroeder
Verena
V
Carter
Angela M
AM
D001792:Blood Platelets / Q000378:metabolism; D001798:Blood Proteins / Q000378:metabolism; D006801:Humans; D007962:Leukocytes / Q000378:metabolism; D009131:Muscle, Smooth, Vascular / Q000378:metabolism; D040901:Proteomics; D012306:Risk; D013927:Thrombosis / Q000097:blood / Q000453:epidemiology / Q000378:metabolism*
D001798:Blood Proteins