title: Stage I breast cancer in a regional oncology practice in Israel 2002-2006: clinicopathologic features, risk estimation and planned therapy of 328 consecutive patients.
abstract: We present the clinicopathologic features and treatment plans of 328 consecutive stage I (T1N0M0) breast cancer patients seen at a regional medical center in Israel. Predicted 10-year mortality risk was calculated using the Adjuvant! Online website. The 21-gene recurrence score (RS) (OncotypeDx) was obtained on a minority of patients. Eighty-nine per cent of patients had estrogen receptor (ER) and/or progesterone receptor (PgR) positive tumors. In 43.3% of patients history of an invasive malignancy was reported in a first degree relative and in 15.5% specifically breast and/or ovarian cancer was reported. Chemotherapy was added to endocrine therapy in 59 ER/PgR positive patients, decreasing predicted 10-year mortality risk by a median of 1.8%. Individualized risk estimation by genetic analysis may further decrease the use of chemotherapy in stage I patients. Breast cancer screening may provide an opportunity to identify cancer prone families.
authors.affiliation: Department of Oncology, Soroka University Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel. dgeffen@bgu.ac.il
authors.forename: D B
authors.initials: DB
authors.lastname: Geffen
authors.forename: N
authors.initials: N
authors.lastname: Amir
authors.forename: N
authors.initials: N
authors.lastname: Sion-Vardy
authors.forename: S
authors.initials: S
authors.lastname: Ariad
authors.forename: L
authors.initials: L
authors.lastname: Kachko
authors.forename: M
authors.initials: M
authors.lastname: Bayme
authors.forename: B
authors.initials: B
authors.lastname: Delgado
authors.forename: V
authors.initials: V
authors.lastname: Dyomin
authors.forename: S
authors.initials: S
authors.lastname: Argov
authors.forename: M
authors.initials: M
authors.lastname: Koretz
mesh_terms: D000328:Adult; D000368:Aged; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology / Q000601:surgery; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D020407:Internet; D007557:Israel / Q000453:epidemiology; D008875:Middle Aged; D018570:Risk Assessment; D013629:Tamoxifen / Q000627:therapeutic use
chemical_list: D018931:Antineoplastic Agents, Hormonal; D013629:Tamoxifen