Oxidant stress in HIV-infected women from the Women's Interagency HIV Study.
BACKGROUND
Oxidant stress contributes to the pathogenesis of multiple conditions and can be assessed by measuring plasma F(2)-isoprostane concentrations. We hypothesized that oxidant stress is associated with plasma homocysteine concentration and risk factors for atherosclerosis in HIV-infected women.


METHODS
We measured plasma F(2)-isoprostane concentrations in a cross-sectional study of 249 HIV-infected women attending the Bronx (NY, USA) site of the Women's Interagency HIV Study and assessed associations with plasma homocysteine concentration and other metabolic parameters by linear regression.


RESULTS
In multivariate analysis, hepatitis C virus (HCV) viraemia, waist circumference, homocysteine concentration and serum aspartate aminotransferase level were positively associated with log F(2)-isoprostane concentration (all P<0.005). There was a trend for an inverse association between log F(2)-isoprostane and CD4(+) T-cell percentage (P=0.06). Among women with HCV infection, the FIB-4 index, an indirect marker of liver fibrosis derived from routine laboratory tests, was positively associated with log F(2)-isoprostane concentration.


CONCLUSIONS
In this cross-sectional study of HIV-infected women, plasma F(2)-isoprostane concentration was positively associated with homocysteine concentration, as well as HCV infection, abdominal obesity and aspartate aminotransferase level.
Glesby
Marshall J
MJ
Division of Infectious Diseases, Department of Medicine, Weill Cornell Medical College, New York, NY, USA. mag2005@med.cornell.edu
Hoover
Donald R
DR
Raiszadeh
Farbod
F
Lee
Irene
I
Shi
Qiuhu
Q
Milne
Ginger
G
Sanchez
Stephanie C
SC
Gao
Wei
W
Kaplan
Robert C
RC
Morrow
Jason D
JD
Anastos
Kathryn
K
D000328:Adult; D050197:Atherosclerosis / Q000150:complications; D003430:Cross-Sectional Studies; D028441:F2-Isoprostanes / Q000378:metabolism; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000378:metabolism*; D006710:Homocysteine / Q000097:blood; D006801:Humans; D008875:Middle Aged; D016877:Oxidants; D018384:Oxidative Stress; D012307:Risk Factors
D028441:F2-Isoprostanes; D016877:Oxidants; D006710:Homocysteine