title: Irritable bowel syndrome symptoms and health related quality of life in female veterans.
abstract: BACKGROUND
  The status and determinants of health-related quality of life (HRQOL) in female veterans with and without irritable bowel syndrome (IBS) are unknown.
  
  
  OBJECTIVE
  To compare HRQOL in female veterans with and without IBS symptoms and examine the contribution of post-traumatic stress disorder, depression and anxiety to HRQOL.
  
  
  METHODS
  A cross-sectional study of 339 female veterans. Self-report questionnaires were used to evaluate IBS symptoms, post-traumatic stress disorder, depression, anxiety and HRQOL.
  
  
  RESULTS
  Symptoms consistent with IBS were present in 33.5% of participants. Female veterans with IBS symptoms had significant reductions in physical component score and 5 of 8 Health Related Quality of Life subscales and on 7 of 8 Irritable Bowel Syndrome Quality Of Life subscales than female veterans without IBS symptoms. Compared with the US general female population, female veterans had significantly lower Health Related Quality of Life physical component score and mental component scores (MCS) irrespective of IBS symptom status. Differences in the MCS score were most explained by depression, while those in the physical component score were most explained by anxiety.
  
  
  CONCLUSIONS
  Irritable bowel syndrome symptoms in female veterans are associated with considerable reduction in HRQOL. However, female veterans, regardless of IBS symptom status, have lower HRQOL compared with the general US female population.
authors.affiliation: Houston Center for Quality of Care and Utilization Studies, Michael E. DeBakey Department of Veterans Affairs Medical Center, Houston, TX 77030, USA. david.graham@med.va.gov
authors.forename: D P
authors.initials: DP
authors.lastname: Graham
authors.forename: L
authors.initials: L
authors.lastname: Savas
authors.forename: D
authors.initials: D
authors.lastname: White
authors.forename: R
authors.initials: R
authors.lastname: El-Serag
authors.forename: S
authors.initials: S
authors.lastname: Laday-Smith
authors.forename: G
authors.initials: G
authors.lastname: Tan
authors.forename: H B
authors.initials: HB
authors.lastname: El-Serag
mesh_terms: D000203:Activities of Daily Living / Q000523:psychology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000453:epidemiology / Q000523:psychology*; D008875:Middle Aged; D011788:Quality of Life / Q000523:psychology*; D012016:Reference Values; D012720:Severity of Illness Index; D013313:Stress Disorders, Post-Traumatic / Q000150:complications / Q000453:epidemiology / Q000523:psychology*; D011795:Surveys and Questionnaires; D014481:United States / Q000453:epidemiology; D014728:Veterans