title: Combination of radiotherapy and chemotherapy in locally advanced NSCLC.
abstract: The combination of radiotherapy and chemotherapy is considered to be a standard approach for patients with locally advanced, stage III non-small-cell lung cancer. The current state of the art of combined radiochemotherapy supported by evidence-based data is presented. As shown in the meta-analyses, the concurrent radiochemotherapy gives a superior outcome in terms of survival compared with sequential delivery of both modalities. This is obtained at the expense of higher toxicity, which makes further intensification of radiochemotherapy challenging. Eligibility of patients with non-small-cell lung cancer for such an approach is limited. The new methods to improve treatment results, such as selection of proper strategies, incorporation of molecular agents into combined treatment and radiotherapy technique modifications are discussed.
authors.affiliation: Department of Radiation Oncology, M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, ul. Roentgena 5, 02-781 Warsaw, Poland. lucynak@coi.pl
authors.forename: Lucyna
authors.initials: L
authors.lastname: Kepka
authors.forename: Arkadiusz
authors.initials: A
authors.lastname: Sprawka
authors.forename: Francesc
authors.initials: F
authors.lastname: Casas
authors.forename: Sherif
authors.initials: S
authors.lastname: Abdel-Wahab
authors.forename: Jai Prakash
authors.initials: JP
authors.lastname: Agarwal
authors.forename: Branislav
authors.initials: B
authors.lastname: Jeremic
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy / Q000401:mortality / Q000532:radiotherapy; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000532:radiotherapy; D009367:Neoplasm Staging; D011832:Radiation Injuries / Q000209:etiology; D015996:Survival Rate
chemical_list: D000970:Antineoplastic Agents