title: Preparation of 4-aminophenylacetic acid derivatives with promising antimicrobial activity.
abstract: Condensation of 4-aminophenylacetic acid with phthalic anhydride gave (dioxoisoindolin-2-yl)phenylacetic acid (1), which was employed as the key intermediate in the synthesis of title compounds 2-8. The products were characterized by analytical and spectral data (IR, 1H NMR, 13C NMR and mass spectra). Antimicrobial activities were studied and some of the compounds showed promising results.
authors.affiliation: Department of Chemistry, Faculty of Science, Al-Azhar University, Nasr City 11884, Cairo, Egypt. Bedair_AH@yahoo.com
authors.forename: Ahmed H
authors.initials: AH
authors.lastname: Bedair
authors.forename: Fawzy M
authors.initials: FM
authors.lastname: Ali
authors.forename: Ahmed M
authors.initials: AM
authors.lastname: El-Agrody
authors.forename: Fathy A
authors.initials: FA
authors.lastname: Eid
authors.forename: Mohammed A A
authors.initials: MA
authors.lastname: El-Nassag
authors.forename: Gamal
authors.initials: G
authors.lastname: El-Sherbeny
mesh_terms: D000814:Aniline Compounds / Q000138:chemical synthesis / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D052978:Disk Diffusion Antimicrobial Tests; D005658:Fungi / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D010648:Phenylacetates / Q000138:chemical synthesis / Q000494:pharmacology*; D013057:Spectrum Analysis
chemical_list: D000814:Aniline Compounds; D000890:Anti-Infective Agents; D010648:Phenylacetates; C109911:4-aminophenylacetic acid