[Phenothiazine-induced dilatation cardiomyopathy: selected aspects of clinical course and morphology].
The author considers selected clinical and morphological characteristics of secondary dilatation cardiomyopathy in patients with schizophrenia after long-term treatment with phenotiazine neuroleptics for the purpose of substantiating nosological self-sufficiency of this pathology (PCMP). 65 cases of PCMP (46 in men and 19 in women) were revealed at postmortem examination (2% of all autopsies or significantly higher than the general incidence of idiopathic dilatation cardiomyopathies (DCMP). Analysis of the patients" medical histories, dynamics of clinical conditions, and results of electrocardiography did not show significant differences between patients with schizophrenia and PCMP compared with mentally healthy DCPM subjects DCMP. Slightly lower heart mass was documented in the former group due to cardiovascular hypoplasia. It is concluded that phenothiazine-induced dilatation cardiomyopathy should be regarded as a separate nosological form belonging to a group of secondary DCMPs and designated as PCMP.
Volkov
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D000981:Antiprotozoal Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002311:Cardiomyopathy, Dilated / Q000139:chemically induced* / Q000453:epidemiology / Q000473:pathology; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology*; D010640:Phenothiazines / Q000009:adverse effects* / Q000627:therapeutic use; D012426:Russia / Q000453:epidemiology; D012559:Schizophrenia / Q000188:drug therapy
D000981:Antiprotozoal Agents; D010640:Phenothiazines