title: Ferrying wingless across the synaptic cleft.
abstract: Secreted Wnt morphogens mediate cell-cell communication, but the mechanism of Wnt transfer between cells is unknown. Korkut et al. (2009) report that the transmembrane protein Evi is a versatile carrier that guides Wingless to presynaptic terminals of motor neurons and then escorts it across the synaptic cleft. In postsynaptic muscles, Evi promotes Frizzled-2 trafficking.
authors.affiliation: Department of Molecular and Cellular Biology, University of Arizona, Tucson, AZ 85721, USA.
authors.forename: Daniela C
authors.initials: DC
authors.lastname: Zarnescu
authors.forename: Konrad E
authors.initials: KE
authors.lastname: Zinsmaier
mesh_terms: D000818:Animals; D004330:Drosophila / Q000378:metabolism*; D029721:Drosophila Proteins / Q000378:metabolism; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism; D021381:Protein Transport; D013569:Synapses; D051155:Wnt1 Protein / Q000378:metabolism
chemical_list: D029721:Drosophila Proteins; D047908:Intracellular Signaling Peptides and Proteins; C511046:Wls protein, Drosophila; D051155:Wnt1 Protein; C074622:wg protein, Drosophila