Regulatory factors in steroid hormone biosynthesis.
Mechanisms of action of steroid hormones have attracted wide attention during the past 4 decades. Central to the field of steroid hormone biochemistry is the probe into the multiple mechanisms that underlie steroid hormone biosynthesis. Several highly fascinating and scholarly reviews have been published on this subject. What the current review intends is to add the information that has been collected during the past decade to the existing literature on factors regulating steroid hormone biosynthesis. A gene regulatory protein that has been central to the investigations conducted at the authors' laboratory during the past two decades has been highlighted. Its potential role in progesterone biosynthesis is also discussed.
Praseetha
S
S
School of Biosciences, SAFI Institute of Advanced Study, Vazhayoor, Malappuram, Kerala, India.
Thampan
Raghava Varman
RV
D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism*; D057137:DAX-1 Orphan Nuclear Receptor / Q000378:metabolism; D004815:Epidermal Growth Factor / Q000378:metabolism; D012739:Gonadal Steroid Hormones / Q000096:biosynthesis* / Q000235:genetics; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism; D026901:Membrane Transport Proteins / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism; D011494:Protein Kinases / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D002352:Carrier Proteins; D057137:DAX-1 Orphan Nuclear Receptor; D012739:Gonadal Steroid Hormones; D008565:Membrane Proteins; D026901:Membrane Transport Proteins; C539965:NR0B1 protein, human; C105684:STARD3 protein, human; D014409:Tumor Necrosis Factor-alpha; C072087:sterol carrier proteins; D004815:Epidermal Growth Factor; D000324:Adrenocorticotropic Hormone; D002784:Cholesterol; D011494:Protein Kinases