title: Selective formation of a linear-shaped bundle of microtubules.
abstract: By using rigid microtubules (MTs) prepared by polymerization with guanylyl-(alpha, beta)-methylene-diphosphonate GMPCPP, giant straight-shaped MT bundles were selectively obtained through a dynamic self-assembly process. We demonstrate the effect of the rigidity on the shape and motility of MT bundle composed of GMPCPP-polymerized MTs (GMPCPP-MTs) compared with control MTs that were polymerized with GTP and stabilized with paclitaxel.
authors.affiliation: Division of Biological Sciences, Graduate School of Science, Hokkaido University, Sapporo 060-0810, Japan.
authors.forename: Ryuzo
authors.initials: R
authors.lastname: Kawamura
authors.forename: Akira
authors.initials: A
authors.lastname: Kakugo
authors.forename: Yoshihito
authors.initials: Y
authors.lastname: Osada
authors.forename: Jian Ping
authors.initials: JP
authors.lastname: Gong
mesh_terms: D000818:Animals; D006160:Guanosine Triphosphate / Q000031:analogs & derivatives / Q000378:metabolism; D016547:Kinesins / Q000378:metabolism; D008870:Microtubules / Q000737:chemistry* / Q000378:metabolism*; D009068:Movement; D013552:Swine; D014404:Tubulin / Q000378:metabolism
chemical_list: D014404:Tubulin; C004805:5'-guanylylmethylenebisphosphonate; D006160:Guanosine Triphosphate; D016547:Kinesins