A new wrinkle in the fold: hepcidin links inflammation to the unfolded protein response.
The unfolded protein response (UPR) coordinates translational and transcriptional changes triggered by unfolded proteins within the endoplasmic reticulum. Two recent papers (Oliveira et al., 2009; Vecchi et al., 2009) show that the UPR modulates transcription of the hormone hepcidin, which controls plasma iron levels and perhaps innate immunity.
De Domenico
Ivana
I
Department of Internal Medicine, University of Utah, Salt Lake City, UT 84132, USA.
Kaplan
Jerry
J
D000818:Animals; D023181:Antimicrobial Cationic Peptides / Q000235:genetics / Q000378:metabolism*; D017362:Cyclic AMP Response Element-Binding Protein / Q000235:genetics / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000378:metabolism; D015966:Gene Expression Regulation, Fungal; D064451:Hepcidins; D007249:Inflammation / Q000378:metabolism*; D051379:Mice; D015398:Signal Transduction / Q000502:physiology; D056811:Unfolded Protein Response / Q000502:physiology*
D023181:Antimicrobial Cationic Peptides; C500051:Creb3l3 protein, mouse; D017362:Cyclic AMP Response Element-Binding Protein; C579599:Hamp protein, mouse; D064451:Hepcidins