title: Two million intrapartum-related stillbirths and neonatal deaths: where, why, and what can be done?
abstract: BACKGROUND
  Intrapartum-related neonatal deaths ("birth asphyxia") are a leading cause of child mortality globally, outnumbering deaths from malaria. Reduction is crucial to meeting the fourth Millennium Development Goal (MDG), and is intimately linked to intrapartum stillbirths as well as maternal health and MDG 5, yet there is a lack of consensus on what works, especially in weak health systems.
  
  
  OBJECTIVE
  To clarify terminology for intrapartum-related outcomes; to describe the intrapartum-related global burden; to present current coverage and trends for care at birth; and to outline aims and methods for this comprehensive 7-paper supplement reviewing strategies to reduce intrapartum-related deaths.
  
  
  RESULTS
  Birth is a critical time for the mother and fetus with an estimated 1.02 million intrapartum stillbirths, 904,000 intrapartum-related neonatal deaths, and around 42% of the 535,900 maternal deaths each year. Most of the burden (99%) occurs in low- and middle-income countries. Intrapartum-related neonatal mortality rates are 25-fold higher in the lowest income countries and intrapartum stillbirth rates are up to 50-fold higher. Maternal risk factors and delays in accessing care are critical contributors. The rural poor are at particular risk, and also have the lowest coverage of skilled care at birth. Almost 30,000 abstracts were searched and the evidence is evaluated and reported in the 6 subsequent papers.
  
  
  CONCLUSIONS
  Each year the deaths of 2 million babies are linked to complications during birth and the burden is inequitably carried by the poor. Evidence-based strategies are urgently needed to reduce the burden of intrapartum-related deaths particularly in low- and middle-income settings where 60 million women give birth at home.
authors.affiliation: Saving Newborn Lives/Save the Children-USA, Cape Town 7405, South Africa. joylawn@yahoo.co.uk
authors.forename: Joy E
authors.initials: JE
authors.lastname: Lawn
authors.forename: Anne C C
authors.initials: AC
authors.lastname: Lee
authors.forename: Mary
authors.initials: M
authors.lastname: Kinney
authors.forename: Lynn
authors.initials: L
authors.lastname: Sibley
authors.forename: Wally A
authors.initials: WA
authors.lastname: Carlo
authors.forename: Vinod K
authors.initials: VK
authors.lastname: Paul
authors.forename: Robert
authors.initials: R
authors.lastname: Pattinson
authors.forename: Gary L
authors.initials: GL
authors.lastname: Darmstadt
mesh_terms: D003906:Developing Countries / Q000706:statistics & numerical data*; D005260:Female; D005313:Fetal Death / Q000453:epidemiology* / Q000517:prevention & control*; D006801:Humans; D011247:Pregnancy; D011295:Prenatal Care / Q000458:organization & administration*; D012307:Risk Factors; D012959:Socioeconomic Factors; D050497:Stillbirth / Q000453:epidemiology*