title: Bipolar affective disorder associated with thenar hypoplasia: is lithium safe?
abstract: Thenar hypoplasia has been described to occur as a part of radial longitudinal deficiency syndromes and occasionally related to Holt-Oram syndrome in which both cardiac and skeletal abnormalities co-occur. We describe a case with bilateral thenar hypoplasia, which resembles a milder variety of Holt-Oram syndrome, who developed bradycardia after exposure to lithium at therapeutic doses.
authors.affiliation: Department of Psychiatry, Central Institute of Psychiatry, Kanke, Ranchi, Jharkhand, India. samirpsyche@yahoo.co.in
authors.forename: Samir Kumar
authors.initials: SK
authors.lastname: Praharaj
authors.forename: Aleem
authors.initials: A
authors.lastname: Siddiqui
authors.forename: Vinod Kumar
authors.initials: VK
authors.lastname: Sinha
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000150:complications / Q000188:drug therapy*; D001919:Bradycardia / Q000139:chemically induced*; D006228:Hand Deformities, Congenital / Q000150:complications; D006801:Humans; D018020:Lithium Compounds / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D013577:Syndrome
chemical_list: D018020:Lithium Compounds