title: SAPS 3 scores at the start of renal replacement therapy predict mortality in critically ill patients with acute kidney injury.
abstract: Patients can experience acute kidney injury and require renal replacement therapy at any time during their admission to intensive care units. Prognostic scores have been used to characterize and stratify patients by the severity of acute disease, but scores based on findings during the day of admission may not be reliable surrogate markers of the severity of acute illness in this population. The aim of this study was to evaluate the performance of SAPS 3 and MPM(0)-III scores, determined at the start of renal replacement therapy, in 244 patients admitted to 11 units of three hospitals in Rio de Janeiro, Brazil. Continuous renal replacement therapy was used as first indication in 84% of these patients. Discrimination by area under the receiver operating characteristic curve was significantly better for SAPS 3 than for MPM(0)-III, as was the calibration measured by the Hosmer-Lemeshow goodness-of-fit test. Mortality prediction and calibration approached those eventually found when a customized equation of SAPS 3 for Central and South America was used. After adjusting for other relevant covariates in multivariate analyses, both higher prognostic scores and length of stay in the unit prior to the start of renal replacement therapy were the main predictive factors for hospital mortality. Our study shows that a customized SAPS 3 model was accurate in predicting mortality and seems a promising algorithm to characterize and stratify patients in clinical studies.
authors.affiliation: NepHro Consultoria em Doenças Renais, Rio de Janeiro, Brazil. emaccariello@yahoo.com.br
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Maccariello
authors.forename: Carla
authors.initials: C
authors.lastname: Valente
authors.forename: Lina
authors.initials: L
authors.lastname: Nogueira
authors.forename: Helio
authors.initials: H
authors.lastname: Bonomo
authors.forename: Marcia
authors.initials: M
authors.lastname: Ismael
authors.forename: Jose Eduardo
authors.initials: JE
authors.lastname: Machado
authors.forename: Fernanda
authors.initials: F
authors.lastname: Baldotto
authors.forename: Marise
authors.initials: M
authors.lastname: Godinho
authors.forename: Ricardo
authors.initials: R
authors.lastname: Valença
authors.forename: Eduardo
authors.initials: E
authors.lastname: Rocha
authors.forename: Marcio
authors.initials: M
authors.lastname: Soares
mesh_terms: D058186:Acute Kidney Injury / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D001938:Brazil; D016638:Critical Illness; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D012372:ROC Curve; D017582:Renal Replacement Therapy / Q000706:statistics & numerical data*; D012720:Severity of Illness Index; D015996:Survival Rate