title: Serum levels of the adipokine chemerin in relation to renal function.
abstract: OBJECTIVE
  To investigate serum levels of the adipokine chemerin in patients on chronic hemodialysis (CD) as compared with control patients with a glomerular filtration rate (GFR) >50 ml/min.
  
  
  METHODS
  Chemerin was quantified by ELISA in control patients (n = 60) and CD patients (n = 60) and correlated with clinical and biochemical measures of renal function, glucose, and lipid metabolism, as well as inflammation, in both groups.
  
  
  RESULTS
  Median serum chemerin levels were more than twofold higher in CD patients (542.2 microg/l) compared with subjects with a GFR >50 ml/min (254.3 microg/l) (P < 0.001). Furthermore, GFR, as assessed by the original Modification of Diet in Renal Disease formula, independently predicted circulating chemerin concentrations in multiple regression analyses in both control patients (P < 0.05) and CD patients (P < 0.01).
  
  
  CONCLUSIONS
  We demonstrate that markers of renal function are independently related to circulating chemerin levels.
authors.affiliation: Department of Internal Medicine III, University of Leipzig, Leipzig, Germany.
authors.forename: Dörte
authors.initials: D
authors.lastname: Pfau
authors.forename: Anette
authors.initials: A
authors.lastname: Bachmann
authors.forename: Ulrike
authors.initials: U
authors.lastname: Lössner
authors.forename: Jürgen
authors.initials: J
authors.lastname: Kratzsch
authors.forename: Matthias
authors.initials: M
authors.lastname: Blüher
authors.forename: Michael
authors.initials: M
authors.lastname: Stumvoll
authors.forename: Mathias
authors.initials: M
authors.lastname: Fasshauer
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D018925:Chemokines / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D007668:Kidney / Q000378:metabolism*; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis
chemical_list: D018925:Chemokines; D036341:Intercellular Signaling Peptides and Proteins; C478630:RARRES2 protein, human