title: Highly effective binding of viologens by p-sulfonatocalixarenes for the treatment of viologen poisoning.
abstract: Viologens are showing an increasing number of scientific and technical applications in addition to their use as herbicides. However, their high toxicity poses considerable risks to human health, society, and the environment. In this context, we propose a new therapeutic protocol for the treatment of viologen poisoning. The mechanism of this new protocol is based on host-guest chemistry and involves the effective inhibition of viologen toxicity by the complexation of p-sulfonatocalix[n]arenes. NMR, ITC, and X-ray crystallography studies indicated that p-sulfonatocalix[n]arenes could form highly stable complexes with viologens. Electrochemical results showed that the highly effective binding could induce the reduction potentials of viologens to shift to more negative values. Further studies in mice showed that the ingestion of p-sulfonatocalix[n]arenes significantly decreased the mortality rate of viologen-poisoned mice with lung and liver protection. As a result, p-sulfonatocalix[n]arenes may have potential application in the clinical treatment of viologen poisoning.
authors.affiliation: Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, P. R. China.
authors.forename: Kui
authors.initials: K
authors.lastname: Wang
authors.forename: Dong-Sheng
authors.initials: DS
authors.lastname: Guo
authors.forename: Hong-Qing
authors.initials: HQ
authors.lastname: Zhang
authors.forename: Dong
authors.initials: D
authors.lastname: Li
authors.forename: Xi-Long
authors.initials: XL
authors.lastname: Zheng
authors.forename: Yu
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000818:Animals; D000931:Antidotes / Q000737:chemistry*; D047250:Calixarenes / Q000737:chemistry*; D062385:Hydroxybenzoates / Q000737:chemistry; D008297:Male; D051379:Mice; D008958:Models, Molecular; D008968:Molecular Conformation; D015203:Reproducibility of Results; D013816:Thermodynamics; D014755:Viologens / Q000737:chemistry* / Q000506:poisoning*
chemical_list: D000931:Antidotes; D062385:Hydroxybenzoates; D014755:Viologens; D047250:Calixarenes; C017616:phenolic acid