Patient perspectives on taking vitamin K antagonists: a qualitative study in the UK, USA and Spain.
OBJECTIVE
Limitations of vitamin K antagonists (VKAs) include frequent monitoring, dietary restrictions and drug interactions. This study conducted an indepth exploration of perspectives of VKA therapy in respondents with atrial fibrillation or venous thromboembolism.


METHODS
A total of 60 respondents, recruited from the UK, USA and Spain, were interviewed on their experiences and views of VKA therapy. Thematic analysis was conducted on the data.


RESULTS
Although there were some differences between the countries and some small differences between atrial fibrillation and venous thromboembolism respondents, many respondents found various aspects of VKA to be burdensome, including the international normalized ratio monitoring and dietary considerations.


CONCLUSIONS
Atrial fibrillation and venous thromboembolism respondents accept the limitations of VKAs and the adjustments to their lifestyles, but recognize a lack of alternative treatment.
Wild
Diane
D
Oxford Outcomes Ltd, Seacourt Tower, West Way, Oxford OX2 OJJ, UK. diane.wild@oxfordoutcomes.com
Murray
Miranda
M
Donatti
Christina
C
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000009:adverse effects / Q000494:pharmacology*; D001281:Atrial Fibrillation / Q000188:drug therapy* / Q000503:physiopathology; D003625:Data Collection; D004032:Diet; D016903:Drug Monitoring / Q000379:methods; D005260:Female; D006801:Humans; D019934:International Normalized Ratio; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D013030:Spain; D006113:United Kingdom; D014481:United States; D054556:Venous Thromboembolism / Q000188:drug therapy* / Q000503:physiopathology; D014812:Vitamin K / Q000037:antagonists & inhibitors*
D000925:Anticoagulants; D014812:Vitamin K