title: Extramammary Paget's disease of the scrotum associated with hepatocellular carcinoma.
abstract: Extramammary Paget's disease (EMPD) is a rare cutaneous carcinoma of epidermal origin. The diagnosis is frequently delayed, and the disease tends to be associated with an underlying adnexal or internal malignancy. There have been several reports of EMPD associated with carcinoma of the bladder, prostate, kidney, and colon. The association of hepatocellular carcinoma (HCC) with EMPD appears to be exceedingly rare; to our knowledge, it has been reported only once in the English literature. Herein, we report an unusual case of EMPD of the scrotum associated with HCC. EMPD was diagnosed 1 year after the appearance of an erythematous plaque, and HCC was noted 19 months after the diagnosis of EMPD. From our experience and literature review, in patients with nonspecific skin lesions that are unresponsive to conventional treatment, EMPD should be considered and skin biopsy performed. Long-term follow-up is needed to watch for the appearance of adnexal carcinoma or internal malignancy.
authors.affiliation: Department of Family Medicine, Taichung Armed Forces General Hospital, Taichung, Taiwan, ROC.
authors.forename: Yu-Ching
authors.initials: YC
authors.lastname: Li
authors.forename: Lieng-Yi
authors.initials: LY
authors.lastname: Lu
authors.forename: Ya-Tang
authors.initials: YT
authors.lastname: Yang
authors.forename: Chen-Chu
authors.initials: CC
authors.lastname: Chang
authors.forename: Li-Mien
authors.initials: LM
authors.lastname: Chen
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000150:complications*; D005834:Genital Neoplasms, Male / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008113:Liver Neoplasms / Q000150:complications*; D008297:Male; D008875:Middle Aged; D010145:Paget Disease, Extramammary / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D012611:Scrotum / Q000473:pathology*