Secondary alcohol hemiacetal formation: an in situ carbonyl activation strategy.
A simple strategy was studied for the reversible nucleophilic addition of secondary alcohols to carbonyl-based receptors to form hemiacetals. It involves the in situ binding of neighboring Brønsted and Lewis acids activators. The addition reaction was successfully observed by UV-vis spectroscopy, thereby laying the groundwork for alcohol optical sensor design.
You
Lei
L
Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, Texas 78712, USA.
Anslyn
Eric V
EV
D000080:Acetals / Q000138:chemical synthesis* / Q000737:chemistry; D000438:Alcohols / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure
D000080:Acetals; D000438:Alcohols; D007659:Ketones