The engineering of brown fat.
The developmental origins of brown adipose tissue and white adipose tissue are distinct, with brown adipocytes being derived from muscle precursors. PR domain containing 16, together with C/EBPbeta, forms a lineage-switching transcriptional complex which promotes brown fat differentiation and suppresses muscle cell differentiation.
Christian
Mark
M
Institute of Reproductive and Developmental Biology, Imperial College London, Du Cane Road, London W12 0NN, UK.
Parker
Malcolm G
MG
D052437:Adipocytes, Brown / Q000166:cytology / Q000378:metabolism*; D002001:Adipose Tissue, Brown / Q000166:cytology / Q000378:metabolism*; D000818:Animals; D022782:CCAAT-Enhancer-Binding Protein-beta / Q000235:genetics / Q000378:metabolism; D002454:Cell Differentiation; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D051379:Mice; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
D022782:CCAAT-Enhancer-Binding Protein-beta; D004268:DNA-Binding Proteins; C521133:Prdm16 protein, mouse; D014157:Transcription Factors