Abnormal distribution of dendritic cells in (NZW x BXSB)F1 mice.
(NZW x BXSB)F1 mice (W/BF1 mice) have been reported to develop autoimmune diseases with aging. We have also reported that the number of dendritic cells (DCs) increases in the various organs, and that the B-cell response to LPS or interleukin-4 plus anti-mu increase with aging in W/BF1 mice. In the present experiment, we show that many DCs exist not only in the T-cell area but also in the B-cell area and the sinus in the spleen of aged W/BF1 mice, and that the coculturing of DCs from aged W/BF1 mice and B cells from disease-free young W/BF1 mice produces much more IgG and IgM than normal mice. These results suggest that an abnormal distribution of DCs and the interaction of DCs and B cells induce the hyperproduction of immunoglobulin in aged W/BF1 mice.
Tokuyama
Yoko
Y
First Department of Pathology, Kansai Medical University, 10-15 Fumizono-cho, Moriguchi-City, Osaka, 570-8506, Japan.
Adachi
Yasushi
Y
Minamino
Keizo
K
Shintaku
Hiroshi
H
Okigaki
Mitsuhiko
M
Hayashi
Kumi
K
Kitajima
Aiko
A
Takaki
Takashi
T
Koike
Naoko
N
Shima
Chieko
C
Imai
Yuichiro
Y
Shi
Ming
M
Yanai
Seiji
S
Ikehara
Susumu
S
D000375:Aging / Q000276:immunology*; D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology; D004247:DNA / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology*; D005260:Female; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D008213:Lymphocyte Activation; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D013154:Spleen / Q000276:immunology
D007074:Immunoglobulin G; D007075:Immunoglobulin M; D004247:DNA