title: Ocular pharmacokinetic study on baicalin in lens of rabbits following intragastric administration.
abstract: OBJECTIVE
  This paper is to study the pharmacokinetic features of baicalin in lens through observing baicalin's concentration changes in lens of rabbits following intragastric administration.
  
  
  METHODS
  Forty-four rabbits were randomly divided into 11 groups. The lens were collected at the beginning without any intragastric administration, and then collected after 15 minutes following intragastric administration of 80 mg/kg baicalin, and continually collected individually after 0.5,0.75,1,1.5,2,3,5,8,12 hours: the concentration of baicalin was measured by reversed-phase high-performance liquid chromatography (RP-HPLC).
  
  
  RESULTS
  There were two obvious peaks in the drug concentration-time diagram, appearing respectively at half an hour and 2 hours after the intragastric administration. The highest level of baicalin's concentration in lens (C( max ), = 4.997 microg/ml) was obtained 0.9 hour (T( max ) = 0.906 h) after application of baicalin. Area under the concentration time curve (AUC), half-life of the drug elimination (T( 1/2 )) and clearance ratio were 3.542 microg/ml*h., 1.576 h and 8.114 l/h respectively.
  
  
  CONCLUSIONS
  Baicalin can penetrate blood-eye barriers and enter the lens following intragastric administration.
authors.affiliation: Department of Ophthalmology, The First Affiliated Hospital of Harbin Medical University, No.23 Youzheng Street, Nangang District, Harbin, 150001 Heilongjiang Province, People's Republic of China. jiazhiyan@126.com
authors.forename: Jia
authors.initials: J
authors.lastname: Zhiyan
authors.forename: Bai
authors.initials: B
authors.lastname: Zhengzhong
authors.forename: Jiang
authors.initials: J
authors.lastname: Liange
authors.forename: Zhang
authors.initials: Z
authors.lastname: Shujie
authors.forename: Duo
authors.initials: D
authors.lastname: Kai
authors.forename: Cui
authors.initials: C
authors.lastname: Hao
authors.forename: Yu
authors.initials: Y
authors.lastname: Yongbin
authors.forename: Liu
authors.initials: L
authors.lastname: Ping
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000493:pharmacokinetics*; D019540:Area Under Curve; D018916:Blood-Aqueous Barrier; D001813:Blood-Retinal Barrier; D002851:Chromatography, High Pressure Liquid; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005419:Flavonoids / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005966:Glucuronidase / Q000037:antagonists & inhibitors; D006207:Half-Life; D007908:Lens, Crystalline / Q000378:metabolism*; D011817:Rabbits; D013270:Stomach
chemical_list: D000890:Anti-Infective Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004791:Enzyme Inhibitors; D005419:Flavonoids; C038044:baicalin; D005966:Glucuronidase