title: Design of a new self-etching HEMA-free adhesive.
abstract: The effect of the pH value of single-bottle, self-etching 2-hydroxyethyl methacrylate (HEMA)-free adhesives on their shelf lives with bonding ability was investigated. Two experimental adhesives [SA-1 (pH=3.0); SA-2 (pH=2.1)] comprising 6-methacryloyloxyhexyl phosphonoacetate (6-MHPA), 4-acryloyloxyethyltrimellitic acid (4-AET), Bis-GMA, water, and acetone, in which the pH values were controlled with 1N NaOH, were stored for 6 weeks at 50 degrees C in air. Shear bond strengths of aged adhesives to ground and unetched enamel and dentin were measured at a crosshead speed of 1.0 mm/min, and the data were analyzed by ANOVA. The resin-tooth bonding interfaces were further observed with SEM. With SA-1, the bond strengths to the tooth substrates were maintained throughout the 6 weeks. However, with SA-2, bond strength significantly degraded from weeks 4 to 6 (p<0.05). Based on SEM observation, non-aged and 6-week-aged adhesive SA-1 appeared to be strongly adhered to both enamel and dentin. It was found that the stability of the self-etching adhesive was influenced by its pH value.
authors.affiliation: Department of Research, Shofu Inc, Fukuine, Higashiyama-ku, Kyoto 605-0983, Japan. k-ikemura@shofu.co.jp
authors.forename: Kunio
authors.initials: K
authors.lastname: Ikemura
authors.forename: Kensuke
authors.initials: K
authors.lastname: Ichizawa
authors.forename: Takeshi
authors.initials: T
authors.lastname: Endo
mesh_terms: D000134:Acid Etching, Dental / Q000379:methods*; D000179:Acrylates / Q000737:chemistry*; D000704:Analysis of Variance; D000818:Animals; D017438:Bisphenol A-Glycidyl Methacrylate / Q000737:chemistry; D002417:Cattle; D003738:Dental Cements / Q000737:chemistry* / Q000494:pharmacology; D003743:Dental Enamel / Q000187:drug effects / Q000648:ultrastructure*; D019232:Dental Restoration Failure; D003799:Dental Stress Analysis; D003804:Dentin / Q000187:drug effects / Q000648:ultrastructure*; D004338:Drug Combinations; D004356:Drug Storage; D006863:Hydrogen-Ion Concentration; D007180:Incisor; D008689:Methacrylates / Q000737:chemistry*; D010746:Phosphonoacetic Acid / Q000031:analogs & derivatives* / Q000737:chemistry; D033081:Shear Strength; D013997:Time Factors; D014233:Tricarboxylic Acids / Q000737:chemistry*
chemical_list: C546896:4-acryloyloxyethyltrimellitic acid; C546895:6-methacryloyloxyhexyl phosphonoacetate; D000179:Acrylates; D003738:Dental Cements; D004338:Drug Combinations; D008689:Methacrylates; D014233:Tricarboxylic Acids; D017438:Bisphenol A-Glycidyl Methacrylate; C005044:hydroxyethyl methacrylate; D010746:Phosphonoacetic Acid