title: Antibiofilm phenylethanoid glycosides from Penstemon centranthifolius.
abstract: Bioassay-guided fractionation of the antibacterial ethyl acetate-ethanol (50 : 50) extract obtained from the aerial parts of Penstemon centranthifolius led to the isolation of six phenylethanoid glycosides (1-6) and eleven iridoid glycosides (7-17). Their structures were determined on the basis of spectroscopic analysis and comparison with the literature. Among them, two phenylethanoid glycosides, 4'''-O-acetylverbascoside (1) and verbascoside (2), were found to show significant inhibition of the formation of bacterial biofilms by Escherichia coli UTI89. Compound 1 showed 77% biofilm inhibition at 2.5 microg/mL, and compound 2 showed 60% inhibition at 5 microg/mL.
authors.affiliation: Key Laboratory of Brain Functional Genomics, East China Normal University, Shanghai, China.
authors.forename: Miao
authors.initials: M
authors.lastname: Ye
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhao
authors.forename: Vanessa L
authors.initials: VL
authors.lastname: Norman
authors.forename: Courtney M
authors.initials: CM
authors.lastname: Starks
authors.forename: Stephanie M
authors.initials: SM
authors.lastname: Rice
authors.forename: Matt G
authors.initials: MG
authors.lastname: Goering
authors.forename: Mark
authors.initials: M
authors.lastname: O'Neil-Johnson
authors.forename: Gary R
authors.initials: GR
authors.lastname: Eldridge
authors.forename: Jin-Feng
authors.initials: JF
authors.lastname: Hu
mesh_terms: D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects*; D004926:Escherichia coli / Q000187:drug effects; D005960:Glucosides / Q000302:isolation & purification / Q000494:pharmacology*; D006027:Glycosides / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D032263:Penstemon / Q000737:chemistry*; D010636:Phenols / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D059808:Polyphenols
chemical_list: D000900:Anti-Bacterial Agents; D005960:Glucosides; D006027:Glycosides; D010636:Phenols; D010936:Plant Extracts; C550314:4'''-O-acetylverbascoside; C058956:acteoside; D059808:Polyphenols