title: [A successfully resected case of liver metastasis of gastrointestinal stromal tumor responding to neoadjuvant chemotherapy with imatinib mesylate and interventional radiology].
abstract: A 75-year-old woman underwent resection of gastrointestinal stromal tumor (GIST) of small intestine in 1999. In January 2006, she suffered liver dysfunction and abdominal CT revealed she had a large liver metastasis. At first the tumor in the right lobe progressed to the medial segment and seemed unresectable. She twice underwent transarterial embolization and treatment with 400mg/day of imatinib mesylate. Then percutaneous transhepatic portal embolization was performed. As a result, liver metastasis markedly decreased in size, and extended right lobectomy of the liver was performed in June 2006. A large portion of the liver metastasis showed necrosis, but histopathological examination revealed focal remnants of viable tumor cells. In March 2007, radiofrequency ablation was performed for recurrence of remnant liver. The patient has been treated by imatinib mesylate and is alive with no evidence of tumor recurrence.
authors.affiliation: Dept. of Surgery, Otsu Red Cross Hospital.
authors.forename: Jun
authors.initials: J
authors.lastname: Tamura
authors.forename: Yuusuke
authors.initials: Y
authors.lastname: Nakayama
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Kitaguchi
authors.forename: Katsuaki
authors.initials: K
authors.lastname: Ura
authors.forename: Kaoru
authors.initials: K
authors.lastname: Taira
authors.forename: Hideaki
authors.initials: H
authors.lastname: Ooe
authors.forename: Akira
authors.initials: A
authors.lastname: Yoshikawa
authors.forename: Shun-Ichi
authors.initials: S
authors.lastname: Ishigami
authors.forename: Nobuo
authors.initials: N
authors.lastname: Baba
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001549:Benzamides; D017115:Catheter Ablation; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D006801:Humans; D000068877:Imatinib Mesylate; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000556:secondary / Q000601:surgery*; D020360:Neoadjuvant Therapy; D010879:Piperazines / Q000627:therapeutic use*; D011743:Pyrimidines / Q000627:therapeutic use*; D015642:Radiology, Interventional
chemical_list: D000970:Antineoplastic Agents; D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate