Radiation therapy for intrahepatic malignancies.
Historically, radiation was not used in the management of hepatocellular carcinoma and liver metastasis because of the low tolerance of the liver to radiation. More recently, improvements in radiation delivery using advanced techniques, such as 3D conformal radiation therapy, intensity-modulated radiation therapy, image-guided radiation therapy, stereotactic body radiation therapy, proton-beam therapy and internal radiation therapy, have enabled partial and selective irradiation of the liver with promising response rates and toxicity profiles. This review will discuss the different techniques of radiation that can now be used to treat intrahepatic malignancies and the important clinical studies in the medical literature.
Quick
Allison M
AM
Department of Radiation Oncology, Arthur G James Cancer Hospital, Ohio State University Medical Center, 300 West 10th Avenue, Ste 088A, Columbus, OH 43210, USA. allison.quick@osumc.edu
Lo
Simon S
SS
Mayr
Nina A
NA
Kim
Edward Y
EY
D006528:Carcinoma, Hepatocellular / Q000473:pathology / Q000532:radiotherapy*; D002986:Clinical Trials as Topic; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000556:secondary; D011832:Radiation Injuries / Q000209:etiology; D011878:Radiotherapy / Q000379:methods*; D016896:Treatment Outcome