title: One-Pot Synthesis of New Symmetric and Asymmetric Xanthene Dyes.
abstract: Symmetric and asymmetric xanthene dyes have been prepared by a convenient one-step procedure from aldehyde and diol or m-aminophenol precursors using concentrated phosphoric acid as a solvent. This protocol provides access to water-soluble dyes with large Stoke's shifts and far-red fluorescence emission. These compounds are envisioned as components of fluorescence-based sensors for a variety of imaging applications.
authors.affiliation: Center for Molecular Imaging Research, Massachusetts General Hospital/Harvard Medical School, Charlestown, Massachusetts 02129, USA.
authors.forename: Scott A
authors.initials: SA
authors.lastname: Hilderbrand
authors.forename: Ralph
authors.initials: R
authors.lastname: Weissleder