Does hypothalamic inflammation cause obesity?
Obesity-induced inflammation causes cellular resistance to both insulin and leptin. In this issue, Brüning and colleagues (Kleinridders et al., 2009) add to growing evidence that this response occurs in the hypothalamus, as well as in peripheral tissues, which helps to explain how high-fat feeding induces a gradual increase in defended body weight.
Wisse
Brent E
BE
Department of Medicine, Diabetes and Obesity Center of Excellence, University of Washington, Seattle, WA 98195, USA.
Schwartz
Michael W
MW
D000818:Animals; D001835:Body Weight / Q000502:physiology; D004041:Dietary Fats / Q000494:pharmacology*; D004734:Energy Metabolism; D007031:Hypothalamus / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D007328:Insulin / Q000378:metabolism; D020738:Leptin / Q000378:metabolism; D051379:Mice; D053594:Myeloid Differentiation Factor 88 / Q000378:metabolism; D009765:Obesity / Q000209:etiology*
D004041:Dietary Fats; D007328:Insulin; D020738:Leptin; D053594:Myeloid Differentiation Factor 88