Association between ApoE4 allele and deep venous thrombosis: a pilot study.
BACKGROUND
Deep vein thrombosis (DVT) is a multifactorial disease with genetic and acquired risk factors playing in concert in its pathogenesis. ApoE gene polymorphisms seem to have some impact among patients with cardiovascular disease; however, association between DVT and ApoE gene polymorphism has not been evaluated.


METHODS
We aimed to search the relative frequencies ApoE alleles among patients with DVT and healthy participants. We enrolled 59 consecutive patients with DVT and 59 age- and sex-matched healthy controls.


RESULTS
In the DVT group, E3/E4 gene polymorphism was detected in 20 patients (33.9%), in the control group E3/E4 polymorphism was detected in six patients (10.2%; P = .002). In the multivariable regression analysis, E3/E4 was independently associated with 1.31-fold increased risk of DVT (odds ratio [OR] 1.31; 95% confidence interval [CI], 1.30-10.48).


CONCLUSIONS
It seems there is a relationship between ApoE3/E4 gene polymorphism and DVT in the Turkish population. However, this pilot study should be supported with large-scale studies.
Katrancioglu
Nurkay
N
Department of Cardiovascular Surgery, Cumhuriyet University, School of Medicine, Sivas, Turkey. nurkay@gmail.com
Manduz
Sinasi
S
Ozen
Filiz
F
Yilmaz
Mehmet Birhan
MB
Atahan
Erhan
E
Ozdemir
Ozturk
O
Berkan
Ocal
O
D000328:Adult; D000368:Aged; D000483:Alleles; D053327:Apolipoprotein E4 / Q000378:metabolism*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011110:Polymorphism, Genetic; D012307:Risk Factors; D014421:Turkey; D020246:Venous Thrombosis / Q000235:genetics*
D053327:Apolipoprotein E4