T cell-mediated control of Epstein-Barr virus infection in humanized mice.
Humanized NOD/Shi-scid/interleukin-2Rgamma(null) (NOG) mice with full T cell development had significantly longer life span after Epstein-Barr virus (EBV) infection, compared with those with minimal T cell development. Removing CD3(+) or CD8(+) T cells from EBV-infected humanized mice by administration of anti-CD3 or anti-CD8 antibodies reduced their life span. CD8(+) T cells obtained from EBV-infected mice suppressed the outgrowth of autologous B cells isolated from uninfected mice and inoculated with EBV in vitro. These results indicate that humanized NOG mice are capable of T cell-mediated control of EBV infection and imply their usefulness as a tool to evaluate immunotherapeutic and prophylactic strategies for EBV infection.
Yajima
Misako
M
Department of Infectious Diseases, National Research Institute for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo, Japan.
Imadome
Ken-Ichi
K
Nakagawa
Atsuko
A
Watanabe
Satoru
S
Terashima
Kazuo
K
Nakamura
Hiroyuki
H
Ito
Mamoru
M
Shimizu
Norio
N
Yamamoto
Naoki
N
Fujiwara
Shigeyoshi
S
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology / Q000821:virology; D017252:CD3 Complex / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000821:virology; D004195:Disease Models, Animal; D020031:Epstein-Barr Virus Infections / Q000276:immunology*; D005260:Female; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology; D008136:Longevity / Q000276:immunology; D051379:Mice; D016176:T-Lymphocyte Subsets / Q000276:immunology* / Q000821:virology
D017252:CD3 Complex