Direct alkenylation and alkylation of pyridone derivatives by Ni/AlMe(3) catalysis.
Regioselective alkenylation and alkylation of 2-pyridone derivatives are achieved through inter- and intramolecular insertion of alkynes, 1,3-dienes, and alkenes into the C(6)-H bond by nickel/AlMe(3) catalysis. Coordination of the heterocycles to the Lewis acid cocatalyst through their basic carbonyl oxygen is considered to be responsible for the regioselective activation of the C-H bonds, probably through oxidative addition to nickel(0).
Nakao
Yoshiaki
Y
Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 615-8510, Japan. yoshiakinakao@npc05.mbox.media.kyoto-u.ac.jp
Idei
Hiroaki
H
Kanyiva
Kyalo Stephen
KS
Hiyama
Tamejiro
T
D000475:Alkenes; D000478:Alkylation; D000480:Alkynes; D002384:Catalysis; D009532:Nickel / Q000737:chemistry; D011728:Pyridones / Q000737:chemistry*
D000475:Alkenes; D000480:Alkynes; D011728:Pyridones; D009532:Nickel