Synthesis of bis-Schiff bases of isatins and their antiglycation activity.
Bis-Schiff bases 1-27 have been synthesized and their in vitro antiglycation potential has been evaluated. Compounds 21 (IC(50)=243.95+/-4.59microM), 20 (IC(50)=257.61+/-5.63microM), and 7 (IC(50)=291.14+/-2.53microM) showed an excellent antiglycation activity better than the standard (rutin, IC(50)=294.46+/-1.50microM). This study has identified a series of potential molecules as antiglycation agents. A structure-activity relationship has been studied, and all the compounds were characterized by spectroscopic techniques.
Khan
Khalid Mohammed
KM
H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University Karachi, Karachi 75270, Pakistan. hassaan2@super.net.pk
Khan
Momin
M
Ali
Muhammad
M
Taha
Muhammad
M
Rasheed
Saima
S
Perveen
Shahnaz
S
Choudhary
M Iqbal
MI
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D005947:Glucose / Q000378:metabolism*; D006031:Glycosylation / Q000187:drug effects; D020128:Inhibitory Concentration 50; D007510:Isatin / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D012545:Schiff Bases / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013057:Spectrum Analysis
D000900:Anti-Bacterial Agents; D012545:Schiff Bases; D007510:Isatin; D005947:Glucose