Effects of acacia honey on wound healing in various rat models.
Honey is a traditional remedy for the treatment of infected wounds, and is becoming more important as microbial resistance to conventional therapeutic agents increases. A study was conducted to assess the wound-healing activity of Acacia honey using incision, excision, burn and dead-space wound models in rats. Different formulations of honey were used and rats were treated topically as well as orally. Both the higher and lower doses of honey produced a significant effect on healing (p < 0.05). The area of epithelization was found to increase, followed by an increase in wound contraction, skin-breaking strength, tissue granulation. The hydroxyproline content also increased in the rats treated with higher doses of honey compared to control, indicating an increase in collagen formation.
Iftikhar
F
F
Department of Honey Bee Research, National Agricultural Research Council, PO NARC, Park Road, Islamabad, Pakistan.
Arshad
M
M
Rasheed
F
F
Amraiz
D
D
Anwar
P
P
Gulfraz
M
M
D000045:Acacia; D000284:Administration, Oral; D000287:Administration, Topical; D000818:Animals; D002056:Burns / Q000628:therapy*; D004353:Drug Evaluation, Preclinical; D005260:Female; D006722:Honey / Q000633:toxicity; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D023382:Toxicity Tests, Acute; D014945:Wound Healing; D014950:Wounds, Penetrating / Q000628:therapy*