A rare trigger for macrophage activation syndrome.
Macrophage activation syndrome (MAS) is a disorder characterized by increased activation of mononuclear cells leading to phagocytosis of blood cell precursors in the bone marrow. We describe a case of MAS triggered by disseminated histoplasmosis occurring in a patient with Still's disease on long-term treatment with adalimumab.
Agarwal
Shikhar
S
Department of Internal Medicine, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA. dr.shikhar.agarwal@gmail.com
Moodley
Jayavani
J
Ajani Goel
Gati
G
Theil
Karl S
KS
Mahmood
Syed S
SS
Lang
Richard S
RS
D000068879:Adalimumab; D000911:Antibodies, Monoclonal / Q000009:adverse effects*; D061067:Antibodies, Monoclonal, Humanized; D018501:Antirheumatic Agents / Q000009:adverse effects*; D006660:Histoplasmosis / Q000150:complications*; D006801:Humans; D055501:Macrophage Activation Syndrome / Q000209:etiology*; D010587:Phagocytosis; D016706:Still's Disease, Adult-Onset / Q000150:complications* / Q000628:therapy*; D055815:Young Adult
D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D018501:Antirheumatic Agents; D000068879:Adalimumab