title: Potential role of CT perfusion parameters in the identification of solitary intra-axial brain tumor grading.
abstract: In this study, neoplastic perfusion abnormalities were investigated by computed tomography perfusion (CTP) scanning in 38 patients with solitary intra-axial brain tumors (19 with high grade gliomas, 7 with low grade gliomas and 12 with brain metastasis). Regional cerebral blood flow (rCBF), cerebral blood volume (rCBV), mean transit time (rMTT) and permeability surface flow (rPSF) levels were measured in two different regions of interest: (1) enhancing or non-enhancing tumor tissue and (2) a mirror area of apparently normal brain tissue located in the contralateral hemisphere. rCBF mean levels were greater in tumoral tissue than in the contralateral area for high-grade gliomas (p < 0.02). rCBV and rPSF mean values were higher in tumoral tissue than in the contralateral area for high-grade gliomas (p < 0.01 and p < 0.05, respectively) and metastasis (p < 0.05 and p < 0.001, respectively). rCBV mean values of tumoral tissue were greater in high-grade than in low-grade gliomas (p < 0.05). rPSF mean levels of tumoral tissue were higher in metastasis than in low-grade gliomas (p < 0.02). These findings indicate that multi-parametric CTP mapping may contribute to differential diagnosis of solitary intra-axial brain tumors.
authors.affiliation: Neurosurgery Unit, Department of Neurosciences and Rahabilitation, Azienda Ospedaliera-Universitaria, Arcispedale S Anna, Ferrara, Italy. henryfai@tin.it
authors.forename: Enrico
authors.initials: E
authors.lastname: Fainardi
authors.forename: Francesco
authors.initials: F
authors.lastname: Di Biase
authors.forename: Massimo
authors.initials: M
authors.lastname: Borrelli
authors.forename: Andrea
authors.initials: A
authors.lastname: Saletti
authors.forename: Michele
authors.initials: M
authors.lastname: Cavallo
authors.forename: Silvio
authors.initials: S
authors.lastname: Sarubbo
authors.forename: Stefano
authors.initials: S
authors.lastname: Ceruti
authors.forename: Riccardo
authors.initials: R
authors.lastname: Tamarozzi
authors.forename: Arturo
authors.initials: A
authors.lastname: Chieregato
mesh_terms: D000368:Aged; D001783:Blood Flow Velocity / Q000502:physiology; D001932:Brain Neoplasms / Q000145:classification / Q000000981:diagnostic imaging*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005260:Female; D007839:Functional Laterality; D005910:Glioma / Q000145:classification / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010477:Perfusion / Q000379:methods; D018709:Statistics, Nonparametric; D014057:Tomography, X-Ray Computed / Q000379:methods*