title: [Flavonoids from Scutellaria baicalensis and their bioactivities].
abstract: OBJECTIVE
  To study the flavonoids of Scutellaria baicalensis and their bioactivities.
  
  
  METHODS
  Chromatographic methods were used to separate compounds, spectral methods were used to determine the structures and bioactivities of the flavonoids were screened in several models in vitro.
  
  
  RESULTS
  Nine compounds were isolated and identified as baicalein (1), wogonin (2), oroxylin A (3), 5, 7, 2', 6'-tetrahydroxyflavone (4), viscidulin III (5), baicalin (6), wogonoside (7), oroxylin A-7-O-beta-D-glucuronide (8) and chrysin-6-C-alpha-L-arabinopyranosyl-8-C-beta-D-glucopyranoside (9).
  
  
  CONCLUSIONS
  Baicalein had good anti-bacteria activity, and some compounds showed inhibiting activity against IL-1beta converting enzyme. The 13C NMR data of compounds 9 were assigned correctly by 2D nuclear magnetic resonance (NMR).
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, Peking University School of Pharmaceutical Sciences, Beijing 100191, China.
authors.forename: Xi Qin
authors.initials: XQ
authors.lastname: Zhou
authors.forename: Hong
authors.initials: H
authors.lastname: Liang
authors.forename: Xin Hua
authors.initials: XH
authors.lastname: Lu
authors.forename: Shao Qing
authors.initials: SQ
authors.lastname: Cai
authors.forename: Bin
authors.initials: B
authors.lastname: Wang
authors.forename: Yu Ying
authors.initials: YY
authors.lastname: Zhao
mesh_terms: D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D061945:Caspase Inhibitors; D044950:Flavanones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D031364:Scutellaria baicalensis / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D061945:Caspase Inhibitors; D044950:Flavanones; D005419:Flavonoids; D005960:Glucosides; C006680:baicalein; C080669:5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one; C473995:wogonoside