title: Cerium caused life span shortening and oxidative stress resistance in Drosophila melanogaster.
abstract: To investigate the effects of the rare earth element cerium (Ce) on the life span and biomarkers of oxidative stress in the fruit fly (Drosophila melanogaster). Fruit flies were fed on media with different dose of ceric sulfate (1, 4, 16, 64, 256, 1024mg/L, corresponding to cerium concentrations of 0.45, 1.65, 6.91, 26.3, 104, and 429microg/g culture medium). Mean life span, maximum life span, and fertility were calculated. There was a significant decrease in mean life span and maximum life span with increasing doses of cerium. At some concentrations, there was a decrease in reproductive output, especially concentrations >6.91microg/g. We also measured superoxide dismutase (SOD) activity, catalase (CAT) activity, and lipid peroxidation product levels (malondialdehyde (MDA) content). Cerium caused a significant increase in MDA content and decrease in SOD and CAT activities at concentrations >6.91microg/g. These results suggest that cerium may result in oxidative toxicity to D. melanogaster.
authors.affiliation: Institute of Cellular and Molecular Biology, School of Life Science, Xuzhou Normal University, Xuzhou, Jiangsu 221116, PR China.
authors.forename: Shu-Feng
authors.initials: SF
authors.lastname: Huang
authors.forename: Zong-Yun
authors.initials: ZY
authors.lastname: Li
authors.forename: Xiu-Qin
authors.initials: XQ
authors.lastname: Wang
authors.forename: Qiu-Xiang
authors.initials: QX
authors.lastname: Wang
authors.forename: Fang-Fang
authors.initials: FF
authors.lastname: Hu
mesh_terms: D000818:Animals; D002374:Catalase / Q000378:metabolism; D002563:Cerium / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004331:Drosophila melanogaster / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D005298:Fertility / Q000187:drug effects; D008136:Longevity / Q000187:drug effects*; D008297:Male; D008315:Malondialdehyde / Q000032:analysis; D018384:Oxidative Stress / Q000187:drug effects*; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D002563:Cerium; D008315:Malondialdehyde; D002374:Catalase; D013482:Superoxide Dismutase