title: Safety and yield of early cessation of AEDs in video-EEG telemetry and outcomes.
abstract: BACKGROUND
  Video-electroencephalography (VEEG) telemetry is the simultaneous recording of ictal and interictal EEG pattern and paroxysmal behavior to investigate the nature of paroxysmal events.
  
  
  METHODS
  This is a prospective study performed to asses the safety and yield of early discontinuation of antiepileptic drugs (AEDs) in the telemetry unit. Over a 2.5-year period, 50 patients that met the indications for VEEG monitoring were admitted by an epileptologist to neuro-observation units with continuous monitoring, nursing coverage and EEG technicians support during working hours and on-call thereafter. In most cases AEDs (except Phenobarbital) were discontinued in 24h. We prospectively assessed the yield and safety of the telemetry investigation as well as epilepsy surgery outcomes.
  
  
  RESULTS
  Our monitoring answered the study question in 88% of the patients. The question was not answered in 12% of cases due to the lack of recorded events. Our results changed the management in 74% of cases and potentially improved quality of life by decreasing the AEDs consumption and number of seizures per month. Over all, 22% received epilepsy surgery and became either seizure free or their seizures became non-disabling. Our method significantly decreased the duration of hospital admission for monitoring and minimal complications occurred only in 8% of patients.
  
  
  CONCLUSIONS
  In conclusion, our method for short VEEG monitoring has a high yield for diagnosis, minimal complications and is cost effective. These qualities, together with good surgery results validate our method for the investigation and treatment of refractory seizure cases.
authors.affiliation: Department of Medicine, Division of Neurology, University of Saskatchewan, Saskatoon, SK, Canada.
authors.forename: Farzad
authors.initials: F
authors.lastname: Moien-Afshari
authors.forename: Robert
authors.initials: R
authors.lastname: Griebel
authors.forename: Venkat
authors.initials: V
authors.lastname: Sadanand
authors.forename: Mirna
authors.initials: M
authors.lastname: Vrbancic
authors.forename: Lizbeth
authors.initials: L
authors.lastname: Hernandez-Ronquillo
authors.forename: Noel
authors.initials: N
authors.lastname: Lowry
authors.forename: José F
authors.initials: JF
authors.lastname: Téllez Zenteno
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000927:Anticonvulsants / Q000009:adverse effects* / Q000145:classification / Q000627:therapeutic use*; D004569:Electroencephalography / Q000379:methods*; D004827:Epilepsy / Q000175:diagnosis* / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000295:instrumentation / Q000379:methods; D012189:Retrospective Studies; D013686:Telemetry / Q000379:methods; D016896:Treatment Outcome; D014743:Videotape Recording / Q000379:methods*; D055815:Young Adult
chemical_list: D000927:Anticonvulsants