title: A phenomenological model for mechanically mediated growth, remodeling, damage, and plasticity of gel-derived tissue engineered blood vessels.
abstract: Mechanical stimulation has been shown to dramatically improve mechanical and functional properties of gel-derived tissue engineered blood vessels (TEBVs). Adjusting factors such as cell source, type of extracellular matrix, cross-linking, magnitude, frequency, and time course of mechanical stimuli (among many other factors) make interpretation of experimental results challenging. Interpretation of data from such multifactor experiments requires modeling. We present a modeling framework and simulations for mechanically mediated growth, remodeling, plasticity, and damage of gel-derived TEBVs that merge ideas from classical plasticity, volumetric growth, and continuum damage mechanics. Our results are compared with published data and suggest that this model framework can predict the evolution of geometry and material behavior under common experimental loading scenarios.
authors.affiliation: Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, 30332, USA.
authors.forename: Julia
authors.initials: J
authors.lastname: Raykin
authors.forename: Alexander I
authors.initials: AI
authors.lastname: Rachev
authors.forename: Rudolph L
authors.initials: RL
authors.lastname: Gleason
mesh_terms: D016880:Anisotropy; D001808:Blood Vessels / Q000254:growth & development / Q000502:physiology / Q000503:physiopathology; D002478:Cells, Cultured; D003198:Computer Simulation; D004548:Elasticity; D005109:Extracellular Matrix; D005782:Gels; D008433:Mathematics; D040542:Mechanotransduction, Cellular / Q000502:physiology; D008954:Models, Biological; D010812:Physical Stimulation; D013314:Stress, Mechanical; D013816:Thermodynamics; D013997:Time Factors; D023822:Tissue Engineering / Q000379:methods*
chemical_list: D005782:Gels