The influence of 1-10 kD fraction from brains of the hibernating ground squirrel and the Yakut horse on proliferation and protein synthesizing system of Ehrlich ascitic carcinoma cells.
The experimental data presented in the work testify to the cytostatic activity of 1-10 kD polypeptide fractions from brains of the hibernating ground squirrel and the Yakut horse towards Ehrlich ascitic carcinoma (EAC) cells. The experiments on the investigation of the inhibiting influence of 1-10 kD fractions from tissues of the hibernating and cold-adapted animals on protein-synthesizing system of EAC cells allow us to conclude that the cytostatic effect of the fractions is effected at the genetic level in the tumor cells.
Gulevsky
A K
AK
Institute for Problems of Cryobiology and Cryomedicine of the National Akademy of Sciences of Ukraine, Kharkov, Ukraine. ivanou@rambler.ru
Grischenko
V I
VI
Tereschenko
O S
OS
Shchenyavcky
I J
IJ
D000222:Adaptation, Physiological / Q000502:physiology; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism* / Q000473:pathology*; D049109:Cell Proliferation / Q000187:drug effects*; D003080:Cold Temperature; D004247:DNA / Q000378:metabolism; D006605:Hibernation / Q000502:physiology*; D006736:Horses; D010455:Peptides / Q000378:metabolism / Q000494:pharmacology*; D021122:Protein Subunits / Q000378:metabolism / Q000494:pharmacology; D011506:Proteins / Q000378:metabolism*; D012313:RNA / Q000378:metabolism; D012589:Sciuridae
D010455:Peptides; D021122:Protein Subunits; D011506:Proteins; D012313:RNA; D004247:DNA