Hepatitis C infection and apoptosis in hepatocellular carcinoma.
This study was suggested to show apoptotic markers level in Hepatitis C Carcinoma (HCC) patients related to Hepatitis C Virus (HCV) infection and evaluate the Fas and Fas-L levels in each of non-cancerous individuals (controls), HCC and non-HCC patients to show the apoptosis levels which reflects the progression of inflammation and fibrosis in HCV patients. The collected samples were tested by kinetic, ELISA, RT-PCR and other molecular techniques. The obtained results showed that the Fas-upregulations don't change in case of positive viral C infection related to HCC and also in non-HCC. But in negative HCV-RNA, Fas-expression in HCC patients is significant. So, the conclusion is neither Fas nor Fas-L may be affected by viral C infection.
Alkahtani
Saad
S
Department of Biology, Teacher College, King Saud University, P.O. Box 271323, Riyadh 11352, Saudi Arabia.
D017209:Apoptosis; D006528:Carcinoma, Hepatocellular / Q000150:complications* / Q000473:pathology*; D004797:Enzyme-Linked Immunosorbent Assay; D053222:Fas Ligand Protein / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D015967:Gene Expression Regulation, Viral; D016174:Hepacivirus / Q000235:genetics*; D006526:Hepatitis C / Q000150:complications* / Q000473:pathology*; D006801:Humans; D007249:Inflammation; D007700:Kinetics; D008113:Liver Neoplasms / Q000150:complications* / Q000473:pathology*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D000509:alpha-Fetoproteins / Q000378:metabolism; D019014:fas Receptor / Q000378:metabolism
D053222:Fas Ligand Protein; D000509:alpha-Fetoproteins; D019014:fas Receptor