title: Isolation of flavonoids from the heartwood and resin of Prunus avium and some preliminary biological investigations.
abstract: An investigation of the constituents in heartwood and resin of Prunus avium is reported. A mini-library of structurally diverse flavanones and flavones was screened for human cytochrome P450 1A1, 3A4 and 19 (aromatase) inhibition, and for antifungal activity against a panel of pathogenic fungi. The defensive role of these natural plant flavonoids as antifungal phytoalexins and phytoanticipins is discussed.
authors.affiliation: Department of Chemistry and Chemical Biology, McMaster University, 1280 Main Street West, Hamilton, ON, Canada L8S 4M1. jmcnult@mcmaster.ca
authors.forename: James
authors.initials: J
authors.lastname: McNulty
authors.forename: Jerald J
authors.initials: JJ
authors.lastname: Nair
authors.forename: Endreddy
authors.initials: E
authors.lastname: Bollareddy
authors.forename: Kunal
authors.initials: K
authors.lastname: Keskar
authors.forename: Amol
authors.initials: A
authors.lastname: Thorat
authors.forename: Denis J
authors.initials: DJ
authors.lastname: Crankshaw
authors.forename: Alison C
authors.initials: AC
authors.lastname: Holloway
authors.forename: Ghaznia
authors.initials: G
authors.lastname: Khan
authors.forename: Gerard D
authors.initials: GD
authors.lastname: Wright
authors.forename: Linda
authors.initials: L
authors.lastname: Ejim
mesh_terms: D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology*; D065607:Cytochrome P-450 Enzyme Inhibitors; D044950:Flavanones / Q000302:isolation & purification / Q000494:pharmacology*; D047309:Flavones / Q000302:isolation & purification / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects* / Q000472:pathogenicity; D027861:Prunus / Q000737:chemistry*; D012116:Resins, Plant / Q000737:chemistry*; D012717:Sesquiterpenes; D013729:Terpenes / Q000302:isolation & purification / Q000494:pharmacology*; D014934:Wood / Q000737:chemistry*; D000094162:Phytoalexins
chemical_list: D000935:Antifungal Agents; D065607:Cytochrome P-450 Enzyme Inhibitors; D044950:Flavanones; D047309:Flavones; D012116:Resins, Plant; D012717:Sesquiterpenes; D013729:Terpenes; D000094162:Phytoalexins