Absorption, pharmacokinetics, and safety of triclosan after dermal administration.
We evaluated the pharmacokinetics and safety of the antimicrobial agent triclosan after dermal application of a 2% triclosan-containing cream to six volunteers. Percutaneous absorption calculated from urinary excretion was 5.9% +/- 2.1% of the dose (mean +/- standard deviation). The amount absorbed suggests that daily application of a standard adult dose would result in a systemic exposure 890 times lower than the relevant no-observed-adverse-effect level. Triclosan can be considered safe for use in hydrophobic creams.
Queckenberg
Christian
C
Department of Pharmacology, Clinical Pharmacology Unit, University of Cologne, Gleueler Str. 24, D-50931 Cologne, Germany. christian.queckenberg@uk-koeln.de
Meins
Jürgen
J
Wachall
Bertil
B
Doroshyenko
Oxana
O
Tomalik-Scharte
Dorota
D
Bastian
Bärbel
B
Abdel-Tawab
Mona
M
Fuhr
Uwe
U
D000287:Administration, Topical; D000328:Adult; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D008297:Male; D019055:No-Observed-Adverse-Effect Level; D009824:Ointments; D012869:Skin Absorption / Q000502:physiology*; D014260:Triclosan / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics*
D000891:Anti-Infective Agents, Local; D009824:Ointments; D014260:Triclosan