title: Synthesis of 2,3,4-Trisubstituted Thiochromanes using an Organocatalytic Enantioselective Tandem Michael-Henry Reaction.
abstract: Enantioenriched 2,3,4-trisubstituted thiochromanes have been synthesized by using a cupreine-catalyzed tandem Michael addition-Henry reaction between 2-mercaptobenzaldehydes and β-nitrostyrenes. Good diastereoselectivities and enantioselectivities were obtained for the title compounds, which may be further improved through a single recrystallization (up to 98% de and> 99% ee).
authors.affiliation: Department of Chemistry, University of Texas at San Antonio, One UTSA Circle, San Antonio, Texas 78249-0698, USA, ; e-mail: cong.zhao@utsa.edu.
authors.forename: Rajasekhar
authors.initials: R
authors.lastname: Dodda
authors.forename: Joshua J
authors.initials: JJ
authors.lastname: Goldman
authors.forename: Tanmay
authors.initials: T
authors.lastname: Mandal
authors.forename: Cong-Gui
authors.initials: CG
authors.lastname: Zhao
authors.forename: Grant A
authors.initials: GA
authors.lastname: Broker
authors.forename: Edward R T
authors.initials: ER
authors.lastname: Tiekink