title: Anthropometric indices as predictors of the metabolic syndrome and its components in adolescents.
abstract: BACKGROUND
  Overweight and related health problems are becoming increasingly recognized, especially in children and adolescents. For early screening, different anthropometrical measurements of obesity have been proposed to identify individuals at risk. We compared body mass index (BMI), BMI standard deviation score, waist circumference, waist-to-hip ratio (WHR), and waist/height ratio with respect to their power to predict the metabolic syndrome, its components and low-grade inflammation.
  
  
  METHODS
  A total of 79 male Caucasian German adolescents (13-17 years) were studied. All anthropometrical measurements of obesity were recorded and blood samples drawn. Predictive power was estimated using receiver operating characteristic curves, by comparing the area under the curve (AUC).
  
  
  RESULTS
  Except for WHR, all tested anthropometrical measurements of obesity showed comparably good AUC values for correct prediction, with the highest AUC for BMI (P < 0.001, AUC = 0.885 +/- 0.039). Superior prediction power was not observed for BMI standard deviation score, waist circumference, WHR or waist/height ratio. Furthermore, BMI was the best predictor of elevated C-reactive protein levels as a marker for low-grade inflammation (P < 0.001, AUC = 0.786 +/- 0.064).
  
  
  CONCLUSIONS
  In this cross-sectional study the well-established parameter BMI was shown to have the best predictive power to identify metabolic syndrome, its components and markers for low-grade inflammation. Newly developed parameters did not provide superior values. Future longitudinal studies are needed to compare these anthropometrical markers in larger cohorts, incorporating different age groups and ethnic backgrounds.
authors.affiliation: Friedrich-Schiller-University, Clinic of Internal Medicine I, Jena, Germany. christian.jung@med.uni-jena.de
authors.forename: Christian
authors.initials: C
authors.lastname: Jung
authors.forename: Nicole
authors.initials: N
authors.lastname: Fischer
authors.forename: Michael
authors.initials: M
authors.lastname: Fritzenwanger
authors.forename: Hans R
authors.initials: HR
authors.lastname: Figulla
mesh_terms: D000293:Adolescent; D000886:Anthropometry; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis; D016001:Confidence Intervals; D003430:Cross-Sectional Studies; D005858:Germany / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008297:Male; D008403:Mass Screening; D024821:Metabolic Syndrome / Q000175:diagnosis / Q000453:epidemiology*; D009765:Obesity / Q000175:diagnosis / Q000453:epidemiology*; D011237:Predictive Value of Tests; D012372:ROC Curve; D018570:Risk Assessment; D049629:Waist-Hip Ratio
chemical_list: D002097:C-Reactive Protein