Estimating equilibrium constants for aggregation from the product distribution of a dynamic combinatorial library.
Multicomponent chemical systems that exhibit a network of covalent and intermolecular interactions may produce interesting and often unexpected chemical or physical behavior. The formation of aggregates is a well-recognized example and presents a particular analytical challenge. We now report the development of a numerical fitting method capable of estimating equilibrium constants for the formation of aggregates from the product distribution of a dynamic combinatorial library containing self-recognizing library members.
Hunt
Rosemary A R
RA
Centre for Systems Chemistry, Stratingh Institute, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands.
Ludlow
R Frederick
RF
Otto
Sijbren
S
D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D013816:Thermodynamics