Effect of adipic dihydrazide modification on the performance of collagen/hyaluronic acid scaffold.
Collagen and hydrazide-functionalized hyaluronic acid derivatives were hybridized by gelating and genipin crosslinking to form composite hydrogel. The study contributed to the understanding of the effects of adipic dihydrazide modification on the physicochemical and biological properties of the collagen/hyaluronic acid scaffold. The investigation included morphology observation, mechanical measurement, swelling evaluation, and collagenase degradation. The results revealed that the stability of composites was increased through adipic dihydrazide modification and genipin crosslinking. The improved biocompatibility and retention of hyaluronic acid made the composite material more favorable to chondrocytes growing, suggesting the prepared scaffold might be high potential for chondrogenesis.
Zhang
Ling
L
National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China.
Xiao
Yumei
Y
Jiang
Bo
B
Fan
Hongsong
H
Zhang
Xingdong
X
D020341:Absorbable Implants; D000272:Adipates / Q000737:chemistry*; D002448:Cell Adhesion; D049109:Cell Proliferation; D019902:Chondrocytes / Q000502:physiology; D024042:Collagen Type I / Q000737:chemistry*; D003432:Cross-Linking Reagents; D004798:Enzymes / Q000737:chemistry; D006801:Humans; D006820:Hyaluronic Acid / Q000737:chemistry*; D007150:Immunohistochemistry; D057889:Iridoid Glycosides; D039823:Iridoids / Q000737:chemistry; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D016062:Porosity; D013055:Spectrophotometry, Infrared; D017550:Spectroscopy, Fourier Transform Infrared; D013314:Stress, Mechanical; D013718:Tensile Strength; D054457:Tissue Scaffolds / Q000737:chemistry*; D014867:Water / Q000737:chemistry
D000272:Adipates; D024042:Collagen Type I; D003432:Cross-Linking Reagents; D004798:Enzymes; D057889:Iridoid Glycosides; D039823:Iridoids; D014867:Water; D006820:Hyaluronic Acid; C007834:genipin; C010011:adipic dihydrazide