title: Consistently very poorly controlled asthma, as defined by the impairment domain of the Expert Panel Report 3 guidelines, increases risk for future severe asthma exacerbations in The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) study.
abstract: BACKGROUND
  Identification of patients at risk for asthma exacerbations can assist physicians in addressing disease management and improve asthma-related health outcomes.
  
  
  OBJECTIVE
  We sought to evaluate whether level of impairment, as defined by the 2007 asthma guidelines, predicts risk for future asthma exacerbations.
  
  
  METHODS
  The study included children aged 6 to 11 years (n = 82) and adolescent/adult patients aged 12 years and older (n = 725) from The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens study with data representing all components of the impairment domain of the asthma guidelines at baseline, month 12, and month 24. Patients were categorized into 2 cohorts: (1) consistently very poorly controlled (VPC) asthma from baseline through 2 years of follow-up and (2) improved from VPC asthma at baseline (including patients who improved to not well-controlled or well-controlled asthma), with improvement maintained through 2 years of follow-up. Odds ratios (ORs) and 95% CIs for risk of asthma exacerbations at month 30 were generated by using multivariable logistic regression by age group.
  
  
  RESULTS
  After adjustment, children with consistently VPC asthma over the 2-year period demonstrated a 6-fold increased risk of hospitalization, emergency department visit, or corticosteroid burst (OR, 6.4; 95% CI, 1.2-34.5) compared with the improved group. Adolescent/adult patients with consistently VPC asthma were more likely to have a corticosteroid burst (OR, 2.8; 95% CI, 1.7-4.8) or have a hospitalization, emergency department visit, or corticosteroid burst (OR, 3.2; 95% CI, 1.9-5.3).
  
  
  CONCLUSIONS
  Consistently VPC asthma, as defined by the impairment domain of the 2007 asthma guidelines, is strongly predictive of future asthma exacerbations.
authors.affiliation: Genentech, Inc, South San Francisco, Calif 94080, USA. haselkorn.tmirah@gene.com
authors.forename: Tmirah
authors.initials: T
authors.lastname: Haselkorn
authors.forename: James E
authors.initials: JE
authors.lastname: Fish
authors.forename: Robert S
authors.initials: RS
authors.lastname: Zeiger
authors.forename: Stanley J
authors.initials: SJ
authors.lastname: Szefler
authors.forename: Dave P
authors.initials: DP
authors.lastname: Miller
authors.forename: Bradley E
authors.initials: BE
authors.lastname: Chipps
authors.forename: F Estelle R
authors.initials: FE
authors.lastname: Simons
authors.forename: Scott T
authors.initials: ST
authors.lastname: Weiss
authors.forename: Sally E
authors.initials: SE
authors.lastname: Wenzel
authors.forename: Larry
authors.initials: L
authors.lastname: Borish
authors.forename: Eugene R
authors.initials: ER
authors.lastname: Bleecker
mesh_terms: D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D018927:Anti-Asthmatic Agents / Q000627:therapeutic use; D001249:Asthma / Q000188:drug therapy* / Q000453:epidemiology / Q000473:pathology*; D002648:Child; D015331:Cohort Studies; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D017410:Practice Guidelines as Topic; D011446:Prospective Studies; D016896:Treatment Outcome; D014481:United States / Q000453:epidemiology; D055815:Young Adult
chemical_list: D000305:Adrenal Cortex Hormones; D018927:Anti-Asthmatic Agents