title: Brain perfusion SPECT correlates with CSF biomarkers in Alzheimer's disease.
abstract: OBJECTIVE
  Our aim was to study the correlations between cerebrospinal fluid (CSF) biomarker levels such as beta-amyloid 42 (Abeta(42)), total and phosphorylated tau protein (T-tau and P-tau) and brain perfusion SPECT in Alzheimer's disease (AD) using a voxel-based methodology.
  
  
  METHODS
  Patients (n = 31) with clinical features of AD (n = 25) or amnestic mild cognitive impairment (aMCI) (n = 6) were retrospectively included. All subjects underwent the same clinical, neuropsychological and neuroimaging tests. They had a lumbar puncture and a brain perfusion ((99m)Tc-ECD) SPECT within a time interval of 10 (+/-26) days. Correlations between CSF biomarker concentrations and perfusion were studied using SPM2 software. Individual normalised regional activity values were extracted from the eligible clusters for calculation of correlation coefficients.
  
  
  RESULTS
  No significant correlation was found between Abeta(42) concentrations and brain perfusion. A significant correlation (p < 0.01, corrected) was found between T-tau or P-tau concentrations and perfusion in the left parietal cortex.
  
  
  CONCLUSIONS
  Our results suggest a strong correlation between T-tau and P-tau levels and decreased brain perfusion in regions typically affected by neuropathological changes in AD.
authors.affiliation: Université Pierre et Marie Curie-Paris 6, INSERM, UMR-S 678, 75013, Paris, France. habert@imed.jussieu.fr
authors.forename: Marie-Odile
authors.initials: MO
authors.lastname: Habert
authors.forename: Leonardo Cruz
authors.initials: LC
authors.lastname: de Souza
authors.forename: Foudil
authors.initials: F
authors.lastname: Lamari
authors.forename: Nelle
authors.initials: N
authors.lastname: Daragon
authors.forename: Serge
authors.initials: S
authors.lastname: Desarnaud
authors.forename: Claude
authors.initials: C
authors.lastname: Jardel
authors.forename: Bruno
authors.initials: B
authors.lastname: Dubois
authors.forename: Marie
authors.initials: M
authors.lastname: Sarazin
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid* / Q000000981:diagnostic imaging*; D015415:Biomarkers / Q000134:cerebrospinal fluid; D001921:Brain / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D055420:Perfusion Imaging; D012984:Software; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D015415:Biomarkers