Immunologically silent cancer clone transmission from mother to offspring.
Rare cases of possible materno-fetal transmission of cancer have been recorded over the past 100 years but evidence for a shared cancer clone has been very limited. We provide genetic evidence for mother to offspring transmission, in utero, of a leukemic cell clone. Maternal and infant cancer clones shared the same unique BCR-ABL1 genomic fusion sequence, indicating a shared, single-cell origin. Microsatellite markers in the infant cancer were all of maternal origin. Additionally, the infant, maternally-derived cancer cells had a major deletion on one copy of chromosome 6p that included deletion of HLA alleles that were not inherited by the infant (i.e., foreign to the infant), suggesting a possible mechanism for immune evasion.
Isoda
Takeshi
T
Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 1138519, Japan.
Ford
Anthony M
AM
Tomizawa
Daisuke
D
van Delft
Frederik W
FW
De Castro
David Gonzalez
DG
Mitsuiki
Norkio
N
Score
Joannah
J
Taki
Tomohiko
T
Morio
Tomohiro
T
Takagi
Masatoshi
M
Saji
Hiroh
H
Greaves
Mel
M
Mizutani
Shuki
S
D000328:Adult; D001483:Base Sequence; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D016313:Genes, abl; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D007223:Infant; D019656:Loss of Heterozygosity; D008431:Maternal-Fetal Exchange / Q000235:genetics* / Q000276:immunology*; D018895:Microsatellite Repeats; D010677:Philadelphia Chromosome; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000235:genetics / Q000276:immunology; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000235:genetics* / Q000276:immunology*; D012333:RNA, Messenger / Q000235:genetics; D012334:RNA, Neoplasm / Q000235:genetics
D004273:DNA, Neoplasm; D006680:HLA Antigens; D012333:RNA, Messenger; D012334:RNA, Neoplasm