Fc receptors: role in biology and antibody therapy.
Insight into the biological role of antibody (Fc) receptors on immune and endothelial cells increased profoundly over the last decades. Fc receptors have been found to be crucial for normal immunity and to play an important role in the mechanisms of action of antibody therapeutics. This knowledge is key in designing and optimizing novel therapeutic strategies for human disease.
van de Winkel
Jan G J
JG
Department of Immunology, University Medical Center Utrecht, and Genmab, P.O. Box 85199, 3508 AD Utrecht The Netherlands. J.vandeWinkel@genmab.com
D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D054316:Biomarkers, Pharmacological / Q000378:metabolism; D006801:Humans; D007167:Immunotherapy; D011110:Polymorphism, Genetic; D011961:Receptors, Fc / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D015398:Signal Transduction; D014481:United States; D014486:United States Food and Drug Administration
D000911:Antibodies, Monoclonal; D054316:Biomarkers, Pharmacological; D011961:Receptors, Fc