Estrogen actions in the cardiovascular system.
This brief review summarizes the current state of the field for estrogen receptor actions in the cardiovascular system and the cardiovascular effects of hormone replacement therapy (HRT). It is organized into three parts: a short Introduction and overview of the current view of how estrogen works on blood vessels; a summary of the current status of clinical information regarding HRT and cardiovascular effects; and an update on state-of-the-art mouse models of estrogen action using estrogen receptor knockout mice.
Mendelsohn
M E
ME
Molecular Cardiology Research Institute, Tufts Medical Center, Tufts University School of Medicine, Boston, USA.
D000818:Animals; D002320:Cardiovascular Physiological Phenomena / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects* / Q000378:metabolism; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000378:metabolism; D015914:Estrogen Replacement Therapy; D004967:Estrogens / Q000494:pharmacology*; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D009569:Nitric Oxide / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism / Q000502:physiology*
D004967:Estrogens; D011960:Receptors, Estrogen; D009569:Nitric Oxide