title: Chemoembolization facilitates limb salvage surgery in stage III soft tissue sarcoma.
abstract: A 26 year-old male was referred to our unit because of a stage III soft tissue sarcoma in the shoulder girdle-axillary area and reduced forearm-distal arm strength. Imaging studies revealed that the tumor encompassed the axillary artery and brachial plexus. We chemoembolized it using vincristine, adriamycin and cyclophosphamide (VAC) plus gel foam and performed limb salvage surgery (LSS) afterwards. The patient received adjuvant chemotherapy (ifosfamide/mesna, adriamycin, and dacarbazine/MAID) and finally radiation therapy (RT; 6500 cGy total dose). Thirty-six months after the operation the patient remains free of disease, without local recurrence and excellent neurological recovery and functional rehabilitation. In stage III soft tissue sarcomas, especially in proximity with major nerve/arterial bundles, a multimodality approach is mandatory; chemoembolization is very effective in shrinking the tumor and defining its margins so as to make feasible a LSS.
authors.affiliation: Musculoskeletal Department, Memorial Sloan Kettering Cancer Center, New York, USA. jpapa73@yahoo.gr
authors.forename: I
authors.initials: I
authors.lastname: Papanastassiou
authors.forename: M
authors.initials: M
authors.lastname: Ioannou
authors.forename: D
authors.initials: D
authors.lastname: Magoulas
authors.forename: S
authors.initials: S
authors.lastname: Lalos
authors.forename: A E
authors.initials: AE
authors.lastname: Athanassiou
authors.forename: N
authors.initials: N
authors.lastname: Ziras
authors.forename: E
authors.initials: E
authors.lastname: Thanopoulou
authors.forename: N
authors.initials: N
authors.lastname: Demertzis
mesh_terms: D000328:Adult; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D003520:Cyclophosphamide / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D004621:Embolization, Therapeutic; D006801:Humans; D023821:Limb Salvage; D008297:Male; D009367:Neoplasm Staging; D018714:Radiotherapy, Adjuvant; D012509:Sarcoma / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D012983:Soft Tissue Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D000903:Antibiotics, Antineoplastic; D018906:Antineoplastic Agents, Alkylating; D000972:Antineoplastic Agents, Phytogenic; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide