title: Synthesis and antimicrobial activity of 7-(2-substituted phenylthiazolidinyl)-benzopyran-2-one derivatives.
abstract: A series of 7-(2-substituted phenylthiazolidinyl)-benzopyran-2-one derivatives have been synthesized by reaction of 7-amino-4-methyl-benzopyran-2-one (1) with an appropriate substituted aldehydes to obtain various Schiff bases (3a-k) which on treatment with thioglycolic acid afforded the title compounds (4a-k). Purity of the compounds has been confirmed by TLC. Structure of these compounds were established on the bases IR, 1H NMR, 13C NMR and Mass spectral data. Schiff bases and title compounds were evaluated for antibacterial and antifungal activities against various bacterial and fungal strains. The results showed that compounds 3d, 3f, 4d, 4f and 4i (100 microg/ml) exhibited good antibacterial and antifungal activity as that of standard antibiotics Ciprofloxacin and Griseofulvin.
authors.affiliation: Department of Pharmaceutical chemistry, KLE's College of Pharmacy, Vidyanagar, Hubli-580031, Karnataka, India. ronad_p@rediffmail.com
authors.forename: Pradeepkumar M
authors.initials: PM
authors.lastname: Ronad
authors.forename: Malleshappa N
authors.initials: MN
authors.lastname: Noolvi
authors.forename: Sheetal
authors.initials: S
authors.lastname: Sapkal
authors.forename: Satyanarayana
authors.initials: S
authors.lastname: Dharbhamulla
authors.forename: Veeresh S
authors.initials: VS
authors.lastname: Maddi
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D003374:Coumarins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects; D013057:Spectrum Analysis; D053778:Thiazolidines / Q000737:chemistry*
chemical_list: D000890:Anti-Infective Agents; D003374:Coumarins; D053778:Thiazolidines