Prefrontal dysfunction in attention-deficit/hyperactivity disorder as measured by near-infrared spectroscopy.
Recent developments in near-infrared spectroscopy (NIRS) have enabled non-invasive clarification of brain functions in psychiatric disorders with measurement of hemoglobin concentrations as cerebral blood volume. Twenty medication-naïve children with attention-deficit/hyperactivity disorder (ADHD) and 20 age- and sex-matched healthy control subjects participated in the present study after giving consent. The relative concentrations of oxyhemoglobin (oxy-Hb) were measured with frontal probes every 0.1 s during the Stroop color-word task, using 24-channel NIRS machines. During the Stroop color-word task, the oxy-Hb changes in the control group were significantly larger than that in the ADHD group in the inferior prefrontal cortex, especially in the inferior lateral prefrontal cortex bilaterally. The Stroop color-word task used with NIRS may be one useful measurement to assess prefrontal brain dysfunction in ADHD children.
Negoro
Hideki
H
Department of Psychiatry, Nara Medical University School of Medicine, 840 Shijocho Kashihara, Nara, Japan.
Sawada
Masayuki
M
Iida
Junzo
J
Ota
Toyosaku
T
Tanaka
Shohei
S
Kishimoto
Toshifumi
T
D000293:Adolescent; D001289:Attention Deficit Disorder with Hyperactivity / Q000503:physiopathology* / Q000523:psychology*; D001931:Brain Mapping; D016022:Case-Control Studies; D002648:Child; D003118:Color Perception; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D010108:Oxyhemoglobins / Q000378:metabolism*; D010364:Pattern Recognition, Visual; D010775:Photic Stimulation; D017397:Prefrontal Cortex / Q000378:metabolism* / Q000503:physiopathology; D012039:Regional Blood Flow; D019265:Spectroscopy, Near-Infrared / Q000379:methods
D010108:Oxyhemoglobins