title: Effect of vaccination with pneumococcal capsular polysaccharides conjugated to Haemophilus influenzae-derived protein D on nasopharyngeal carriage of Streptococcus pneumoniae and H. influenzae in children under 2 years of age.
abstract: Following primary and booster vaccination with an 11-valent pneumococcall protein D conjugate vaccine there was a 42.8% (95% CI: -16.7 to 71.9, ns) reduction in the carriage of Streptococcus pneumoniae vaccine serotypes and a 42.6% (95% CI: 1.3-66.6) reduction in the carriage of Haemophilus influenzae identified by standard microbiological techniques. When PCR and immunoblot assays were used to further improve specificity of non-typeable H. influenzae strain identification, carriage of H. influenzae was still reduced with 38.6% (95% CI: -6.3 to 64.6, ns). Reduction of acute otitis media (AOM) episodes preceded the impact on carriage. These data provide further support of the functional role of the protein D immunity.
authors.affiliation: Department of Epidemiology, Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic. prymula@pmfhk.cz
authors.forename: Roman
authors.initials: R
authors.lastname: Prymula
authors.forename: Pavla
authors.initials: P
authors.lastname: Kriz
authors.forename: Eva
authors.initials: E
authors.lastname: Kaliskova
authors.forename: Thierry
authors.initials: T
authors.lastname: Pascal
authors.forename: Jan
authors.initials: J
authors.lastname: Poolman
authors.forename: Lode
authors.initials: L
authors.lastname: Schuerman
mesh_terms: D001426:Bacterial Proteins / Q000276:immunology; D002352:Carrier Proteins / Q000276:immunology; D002353:Carrier State / Q000276:immunology / Q000517:prevention & control*; D002675:Child, Preschool; D004269:DNA, Bacterial / Q000302:isolation & purification; D004311:Double-Blind Method; D005260:Female; D006192:Haemophilus Infections / Q000276:immunology / Q000517:prevention & control*; D006801:Humans; D007072:Immunoglobulin D / Q000276:immunology; D007223:Infant; D008074:Lipoproteins / Q000276:immunology; D008297:Male; D009305:Nasopharynx / Q000382:microbiology*; D010033:Otitis Media / Q000382:microbiology / Q000517:prevention & control; D011008:Pneumococcal Infections / Q000276:immunology / Q000517:prevention & control*; D022242:Pneumococcal Vaccines / Q000276:immunology*; D011135:Polysaccharides, Bacterial / Q000276:immunology*; D011446:Prospective Studies; D018074:Vaccines, Conjugate / Q000276:immunology
chemical_list: D001426:Bacterial Proteins; D002352:Carrier Proteins; D004269:DNA, Bacterial; D007072:Immunoglobulin D; D008074:Lipoproteins; D022242:Pneumococcal Vaccines; D011135:Polysaccharides, Bacterial; D018074:Vaccines, Conjugate; C067989:glpQ protein, Haemophilus influenzae