title: Retroperitoneal abscess complicated with necrotizing fasciitis of the thigh in a patient with sigmoid colon cancer.
abstract: BACKGROUND
  Necrotizing fasciitis of the thigh due to the colon cancer, especially during chemotherepy, has not been previously reported.
  
  
  METHODS
  A 67-year-old man admitted to the hospital was diagnosed with sigmoid colon cancer that had spread to the left psoas muscle. Multiple hepatic metastases were also found, and combination chemotherapy with irinotecan and S-1 was administered. Four months after the initiation of chemotherapy, the patient developed gait disturbance and high fever and was therefore admitted to the emergency department of our hospital. Blood examination revealed generalized inflammation with a high C-reactive protein level. Computed tomography of the abdomen and pelvis showed gas and fluid collection in the retroperitoneum adjacent to the sigmoid colon cancer. The abscess was locally drained under computed tomographic guidance; however, the infection continued to spread and necrotizing fasciitis developed. Consequently, emergent debridement was performed. The patient recovered well, and the primary tumor was resected after remission of the local inflammation.
  
  
  CONCLUSIONS
  Necrotizing fasciitis of the thigh due to the spread of sigmoid colon cancer is unusual, but this fatal complication should be considered during chemotherapy for patients with unresectable colorectal cancer.
authors.affiliation: Department of Surgery, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Science, Hiroshima University, Minami-ku, Hiroshima, Japan. ytaka0621@aol.com
authors.forename: Yuji
authors.initials: Y
authors.lastname: Takakura
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ikeda
authors.forename: Masanori
authors.initials: M
authors.lastname: Yoshimitsu
authors.forename: Takao
authors.initials: T
authors.lastname: Hinoi
authors.forename: Daisuke
authors.initials: D
authors.lastname: Sumitani
authors.forename: Haruka
authors.initials: H
authors.lastname: Takeda
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Kawaguchi
authors.forename: Manabu
authors.initials: M
authors.lastname: Shimomura
authors.forename: Masakazu
authors.initials: M
authors.lastname: Tokunaga
authors.forename: Masazumi
authors.initials: M
authors.lastname: Okajima
authors.forename: Hideki
authors.initials: H
authors.lastname: Ohdan
mesh_terms: D000038:Abscess / Q000150:complications* / Q000473:pathology / Q000601:surgery; D000368:Aged; D003646:Debridement; D004927:Escherichia coli Infections / Q000150:complications* / Q000473:pathology / Q000601:surgery; D019115:Fasciitis, Necrotizing / Q000150:complications* / Q000473:pathology / Q000601:surgery; D017809:Fatal Outcome; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary; D008297:Male; D019042:Muscle Neoplasms / Q000556:secondary; D016658:Psoas Muscles / Q000473:pathology; D012187:Retroperitoneal Space; D012811:Sigmoid Neoplasms / Q000150:complications / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D013848:Thigh