title: Rare extraintestinal infection caused by toxin-producing Clostridium difficile.
abstract: Toxigenic Clostridium difficile is a well known cause of antibiotic-associated diarrhea mainly among hospitalized patients, at the same time we have little information about extraintestinal infections caused by this bacterium. We report here on rare extraintestinal infection caused by toxigenic C. difficile: 31-year-old male, accident victim was admitted to the hospital because of polytrauma. Microbiological examination of the pus revealed a toxin-producing C. difficile as an etiologic factor of this infection. Empiric antibiotic treatment with cefuroxime had been administered right after the positive microbiological result. On the basis of antibiotic susceptibility testing, the isolated strain was susceptible to most antimicrobials, except from cefoxitin, thus cefuroxime was changed to imipenem.
authors.affiliation: Institute of Clinical Microbiology, Faculty of Medicine, University of Szeged, Hungary. urban@mlab.szote.u-szeged.hu
authors.forename: Edit
authors.initials: E
authors.lastname: Urbán
authors.forename: Gabriella
authors.initials: G
authors.lastname: Terhes
authors.forename: Attila
authors.initials: A
authors.lastname: Markotics
authors.forename: József
authors.initials: J
authors.lastname: Sóki
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Nagy
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001426:Bacterial Proteins / Q000378:metabolism; D001427:Bacterial Toxins / Q000378:metabolism; D016360:Clostridioides difficile / Q000187:drug effects / Q000302:isolation & purification / Q000472:pathogenicity*; D004768:Enterotoxins / Q000378:metabolism; D018409:Foot Injuries / Q000188:drug therapy / Q000382:microbiology* / Q000601:surgery; D006801:Humans; D008297:Male; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D001427:Bacterial Toxins; D004768:Enterotoxins; C041348:tcdA protein, Clostridium difficile; C031815:toxB protein, Clostridium difficile