Leser-Trélat sign presenting in a patient with ovarian cancer: a case report.
BACKGROUND
Seborrheic keratoses are very common findings in elderly patients. However, a sudden onset and dramatic increase in the number and size of these benign lesions deserves special attention, since this may represent the Leser Trélat sign, a rare paraneoplastic cutaneous syndrome.


METHODS
A 92-year-old female presented to our clinic with multiple eruptive seborrheic keratoses, which had dramatically increased in size and number over the past two years. A diagnostic work-up revealed an ovarian carcinoma. Hence, cutaneous findings in our patient were consistent with the diagnosis of the Leser-Trélat sign.


CONCLUSIONS
The Leser-Trélat sign may coincide with the diagnosis of occult cancer or follow or precede it by months or years. Practitioners should take cases of eruptive seborrheic keratoses seriously and perform thorough patient examinations.
Bölke
Edwin
E
Gerber
Peter Arne
PA
Peiper
Matthias
M
Knoefel
Wolfram Trudo
WT
Cohnen
Mathias
M
Matuschek
Christiane
C
Budach
Wilfried
W
Engers
Rainer
R
Gripp
Stephan
S