Hypothyroidism induced by polychlorinated biphenyls and up-regulation of transthyretin.
Polychlorinated biphenyls are environmental pollutants that are toxic to many biological systems. This study examined whether or not PCB126 and PCB114 have adverse effects on the serum thyroxine level and the serum proteome in rats. The results showed a lower serum total thyroxine level in the PCB126 and PCB114-treated groups than the control. Western blotting showed that the levels of transthyretin expression were significantly higher in the PCB-treated group than the control group. These results suggest that the PCB-mediated hypothyroidism is caused by the displacement of thyroxine from transthyretin.
Han
Dae-Yong
DY
Research Institute of Life Science, Gyeongsang National University, Jinju, 660-701, Korea.
Kang
Sang-Rim
SR
Park
Oh-Sung
OS
Cho
Jae-Hyeon
JH
Won
Chung-Kil
CK
Park
Hyeon-Soo
HS
Park
Kwang-Il
KI
Kim
Eun-Hee
EH
Kim
Gon-Sup
GS
D000818:Animals; D007037:Hypothyroidism / Q000139:chemically induced*; D008297:Male; D011078:Polychlorinated Biphenyls / Q000633:toxicity*; D011228:Prealbumin / Q000235:genetics / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013974:Thyroxine / Q000097:blood; D015854:Up-Regulation / Q000187:drug effects*
D011228:Prealbumin; C035834:2,3,4,4'5-pentachlorobiphenyl; D011078:Polychlorinated Biphenyls; D013974:Thyroxine; C023035:3,4,5,3',4'-pentachlorobiphenyl