title: A comparative study of the effects of ab externo superpulse carbon dioxide laser-assisted trabeculectomy with conventional trabeculectomy in rabbits.
abstract: OBJECTIVE
  The aim of this investigation was to evaluate the efficacy of reduction in intraocular pressure (IOP) and complications in ab externo superpulse carbon dioxide laser-assisted trabeculectomy.
  
  
  BACKGROUND
  Reduction of IOP remains the immediate goal of glaucoma treatment. Although trabeculectomy has been considered the gold standard for the surgical treatment of glaucoma, many complications are associated with this procedure. Laser surgery has been studied as an alternative way to control IOP in glaucoma.
  
  
  METHODS
  Sixty adult albino rabbits were enrolled in this study. The animals underwent one unilateral surgery of either trabeculectomy or ab externo superpulse carbon dioxide laser-assisted trabeculectomy and were divided into two subgroups, control or experimental. Follow-up examinations included ocular anterior segments, filtration blebs and IOP. Five eyes in each group were analyzed histologically one month postoperatively.
  
  
  RESULTS
  Anterior chamber hyphema in the laser group was milder than that in the surgery group, and disappeared on the third day. In the surgery group, it disappeared by the end of the first month. Filtration blebs in the laser group formed earlier than in the surgery group. Comparing the laser group and the surgery group, IOP values in the laser group were more stable. Histological examination showed that the sclera tract was blocked by scar tissue, inflammation had infiltrated, and the anterior chamber angle had adhered in the surgery group.
  
  
  CONCLUSIONS
  Ab externo superpulse carbon dioxide laser-assisted trabeculectomy was suggested as a feasible technique to control IOP with the advantages of more steady IOP reduction and fewer complications.
authors.affiliation: Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Sciences Key Lab., Beijing, China. xmduan_ophthalmologist@yahoo.com
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Duan
authors.forename: Zhongjiang
authors.initials: Z
authors.lastname: He
authors.forename: Xuxiang
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000869:Anterior Eye Segment / Q000601:surgery; D002245:Carbon Dioxide; D005901:Glaucoma / Q000601:surgery; D007429:Intraocular Pressure; D053685:Laser Therapy / Q000379:methods*; D011817:Rabbits; D012599:Sclerostomy / Q000379:methods*; D018709:Statistics, Nonparametric; D014129:Trabecular Meshwork / Q000601:surgery*; D014945:Wound Healing / Q000502:physiology
chemical_list: D002245:Carbon Dioxide