The assessment of glycemic variability and its impact on diabetes-related complications: an overview.
There is a growing body of evidence that the sole use of hemoglobin A1c is insufficient to adequately reflect the metabolic situation of patients with diabetes mellitus. The risk of developing diabetes-related complications apparently not only depends on the long-term stability of glucose values, but also on the presence or occurrence of short-term glycemic peaks and nadirs lasting for minutes or hours during a day. This leads to the phenomenon of glycemic variability. This article reviews the existing evidence for the clinical relevance of short-term glucose variations and the currently available different means of measuring glycemic variability.
Weber
Christian
C
Institute for Medical Informatics and Biostatistics, Basel, Switzerland. weber@imib.ch
Schnell
Oliver
O
D001786:Blood Glucose / Q000378:metabolism*; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000378:metabolism*; D003925:Diabetic Angiopathies / Q000378:metabolism; D003930:Diabetic Retinopathy / Q000378:metabolism; D038321:Glycemic Index
D001786:Blood Glucose