title: Effect of airflow rate on vibration response imaging in normal lungs.
abstract: BACKGROUND
  Evaluating the effect of airflow rate on amplitude of lung sound energy and regional distribution of lung sounds may assist in the interpretation of computerized acoustic measurements.
  
  
  OBJECTIVE
  The aim of this study was to assess the effect of airflow rate on Vibration Response Imaging (VRI) measurement in healthy lungs.
  
  
  METHODS
  Lung sounds were recorded from 20 healthy adults in the frequency range of 150-250 Hz using 40 piezoelectric sensors positioned on the posterior chest wall. During the recordings, subjects were breathing at airflow rates ranging between 0.3 and 1.7L/s. Online visual feedback was provided using a pneumotach mouthpiece.
  
  
  RESULTS
  Amplitude of lung sound energy significantly increased with increasing airflow rate (p<0.00001, Friedman test). A strong relationship (R2=0.95) was obtained between amplitude of lung sound energy at peak inspiration and airflow rate raised to the third power. This correlation did not significantly affect normalized lung sound distribution maps at peak inspiration, especially when airflow was higher than 1.0L/s. Acoustic maps obtained at airflow rates below 0.7L/s differed from those recorded above 1.0L/s (p<0.05, Wilcoxon matched-paired signed-ranks test).
  
  
  CONCLUSIONS
  These findings may be of importance when comparing healthy and diseased lungs or when monitoring changes in lung sounds during treatment follow-up.
authors.affiliation: Deep Breeze, Ltd., 2 Hailan St., P.O. Box 140, Or-Akiva, 30600, Israel.
authors.forename: Meirav
authors.initials: M
authors.lastname: Yosef
authors.forename: Ruben
authors.initials: R
authors.lastname: Langer
authors.forename: Shaul
authors.initials: S
authors.lastname: Lev
authors.forename: Yael A
authors.initials: YA
authors.lastname: Glickman