Intramolecular base-accelerated radical-scavenging reaction of a planar catechin derivative bearing a lysine moiety.
A planar catechin derivative incorporating a lysine moiety was synthesized and showed approximately 400-fold increased radical-scavenging activity relative to naturally-occurring (+)-catechin.
Fukuhara
Kiyoshi
K
Division of Organic Chemistry, National Institute of Health Sciences, Setagaya-ku, Tokyo 158-8501, Japan. fukuhara@nihs.go.jp
Nakanishi
Ikuo
I
Ohkubo
Kei
K
Obara
Yoshinori
Y
Tada
Ayako
A
Imai
Kohei
K
Ohno
Akiko
A
Nakamura
Asao
A
Ozawa
Toshihiko
T
Urano
Shiro
S
Saito
Shinichi
S
Fukuzumi
Shunichi
S
Anzai
Kazunori
K
Miyata
Naoki
N
Okuda
Haruhiro
H
D002392:Catechin / Q000031:analogs & derivatives*; D016166:Free Radical Scavengers / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008239:Lysine / Q000737:chemistry*; D008958:Models, Molecular
D016166:Free Radical Scavengers; D002392:Catechin; D008239:Lysine