title: Combined hepatectomy and radiofrequency ablation for multifocal hepatocellular carcinoma: a case report.
abstract: BACKGROUND
  At the present time, the best possible choice for the local management of a multifocal hepatocellular carcinoma (HCC) developing on liver cirrhosis is multimodal treatment of the disease. Combined approach based on simultaneous radiofrequency ablation (RFA) together with limited surgical resection represents a valid choice of treatment.
  
  
  METHODS
  A 75-year-old white female patient affected of HCV-associated cirrhosis in Child-Pugh's functional class A5, developed a bifocal HCC. The patient had undergone a limited surgical resection together with simultaneous RFA, without intraoperative and postoperative surgical complications. At 36 months after surgery, still shows no sign of disease relapse.
  
  
  CONCLUSIONS
  This strategy directed at the management of multifocal HCC, may prove more useful for the reduction of surgical risk and post-operative progression of the liver cirrhosis than large-scale hepatectomy, since it presents no peri-operative mortality and a complication rate of less than 10%.
authors.affiliation: Department of Oncology, Division of General and Oncological Surgery, University of Palermo, Interdepartmental Unit for HepaticNeoplasia Group, Via del Vespro 129, 90127 Palermo, Italy. sandonatoluigi@libero.it
authors.forename: Luigi
authors.initials: L
authors.lastname: Sandonato
authors.forename: Calogero
authors.initials: C
authors.lastname: Cipolla
authors.forename: Maurizio
authors.initials: M
authors.lastname: Soresi
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Lo Re
authors.forename: Federica
authors.initials: F
authors.lastname: Latteri
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Lombardo
authors.forename: Valentina
authors.initials: V
authors.lastname: Bova
authors.forename: Mario Adelfio
authors.initials: MA
authors.lastname: Latteri