Efficient method for the synthesis of functionalized pyrazoles by catalyst-free one-pot tandem reaction of nitroalkenes with ethyl diazoacetate.
The one-pot synthesis of multisubstituted pyrazole derivatives was achieved via catalyst-free 1,3-dipolar cycloaddition of ethyl diazoacetate and nitroalkenes as the key step and elimination of the leaving group (NO(2) or Br) followed by intramolecular proton transfer with satisfactory yields.
Xie
Jian-Wu
JW
Department of Chemistry and Life Science, Zhejiang Normal University, Jinhua, 321004, China. xiejw@zjnu.cn
Wang
Zheng
Z
Yang
Wei-Jun
WJ
Kong
Li-Chun
LC
Xu
Dong-Cheng
DC
D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D003979:Diazonium Compounds / Q000737:chemistry*; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry
D000475:Alkenes; D003979:Diazonium Compounds; D011720:Pyrazoles; C032111:diazoacetic ester