title: Microglial/macrophage cells in mammalian olfactory nerve fascicles.
abstract: This is the first description of a population of Iba1- and annexin A3-immunopositive cells residing in the peripheral olfactory nerves of adult rats and adult cats. Based on their ramified appearance, positive immunostaining for the monocytic markers Iba1 and annexin A3, and reactivity to bulbectomy (in adult rats), these cells found within the olfactory nerve fascicles of both mammalian species meet several important criteria for their designation as microglia/macrophages. These Iba1-/annexin A3-immunopositive cells may be uniquely positioned to protect against the potential spread of dangerous environmental xenobiotics (such as viruses and toxins) into the brain, where such pathogens may contribute to the development of neurological diseases, such Alzheimer's and Parkinson's diseases.
authors.affiliation: Department of Anatomy and Cell Biology, Centre for Neuroscience Studies, Queen's University, Kingston, Ontario, Canada.
authors.forename: Laura J
authors.initials: LJ
authors.lastname: Smithson
authors.forename: Michael D
authors.initials: MD
authors.lastname: Kawaja
mesh_terms: D000818:Animals; D017318:Annexin A3 / Q000378:metabolism; D002135:Calcium-Binding Proteins / Q000378:metabolism; D002415:Cats; D008264:Macrophages / Q000378:metabolism / Q000502:physiology*; D008297:Male; D008840:Microfilament Proteins; D017628:Microglia / Q000378:metabolism / Q000502:physiology*; D009830:Olfactory Bulb / Q000293:injuries / Q000378:metabolism*; D009831:Olfactory Mucosa / Q000166:cytology* / Q000648:ultrastructure; D009832:Olfactory Nerve / Q000166:cytology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: C100745:Aif1 protein, rat; D002135:Calcium-Binding Proteins; D008840:Microfilament Proteins; D017318:Annexin A3