Antibiofilm phenylethanoid glycosides from Penstemon centranthifolius.
Bioassay-guided fractionation of the antibacterial ethyl acetate-ethanol (50 : 50) extract obtained from the aerial parts of Penstemon centranthifolius led to the isolation of six phenylethanoid glycosides (1-6) and eleven iridoid glycosides (7-17). Their structures were determined on the basis of spectroscopic analysis and comparison with the literature. Among them, two phenylethanoid glycosides, 4'''-O-acetylverbascoside (1) and verbascoside (2), were found to show significant inhibition of the formation of bacterial biofilms by Escherichia coli UTI89. Compound 1 showed 77% biofilm inhibition at 2.5 microg/mL, and compound 2 showed 60% inhibition at 5 microg/mL.
Ye
Miao
M
Key Laboratory of Brain Functional Genomics, East China Normal University, Shanghai, China.
Zhao
Yun
Y
Norman
Vanessa L
VL
Starks
Courtney M
CM
Rice
Stephanie M
SM
Goering
Matt G
MG
O'Neil-Johnson
Mark
M
Eldridge
Gary R
GR
Hu
Jin-Feng
JF
D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects*; D004926:Escherichia coli / Q000187:drug effects; D005960:Glucosides / Q000302:isolation & purification / Q000494:pharmacology*; D006027:Glycosides / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D032263:Penstemon / Q000737:chemistry*; D010636:Phenols / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D059808:Polyphenols
D000900:Anti-Bacterial Agents; D005960:Glucosides; D006027:Glycosides; D010636:Phenols; D010936:Plant Extracts; C550314:4'''-O-acetylverbascoside; C058956:acteoside; D059808:Polyphenols