title: Effect of anterior chamber air bubble on prevention of experimental Staphylococcus epidermidis endophthalmitis.
abstract: BACKGROUND
  Bacterial endophthalmitis is a serious complication of penetrating ocular trauma and cataract surgery. The purpose of this study is to assess the ability of an anterior chamber air bubble to prevent experimental Staphylococcus epidermidis endophthalmitis.
  
  
  METHODS
  The anterior chamber was opened with a clear corneal incision to drain the aqueous humor in one eye of 24 rabbits. S. epidermidis was injected into the anterior chamber. The infected rabbits were randomly divided into two groups. Animals in group 1 (n = 12) received an air bubble to reconstruct the anterior chamber, and animals in Group 2 (n = 12) received Balanced Salt Solution (BSS) for reconstruction. Clinical examination in each group was performed 2, 3 and 7 days after inoculation of the bacteria. Clinical examination scores were recorded. All eyes were enucleated for histophatological examination.
  
  
  RESULTS
  Clinical endophthalmitis was seen in 7/12 (58.3%) in group 2, but in only 1/12 (8.3%) in group 1 (p = 0.027). Mean clinical scores of groups 1and 2 on the 3rd day were 2.6 +/- 1.4 and 7.2 +/- 1.7 respectively. (p < 0.001). The mean clinical scores of groups 1and 2 on the 7th day were 2.3 +/- 1.2 and 6.8 +/- 1.5 respectively (p < 0.001). Histopathological examination confirmed clinical findings.
  
  
  CONCLUSIONS
  An air bubble in the anterior chamber may have protective effects against the development of experimental S. epidermidis endophthalmitis.
authors.affiliation: Department of Ophthalmology, Shiraz University of Medical Sciences, Poostchi Ophthalmology Research Center, Shiraz 71935, Iran. mehdizadem@gmail.com
authors.forename: Morteza
authors.initials: M
authors.lastname: Mehdizadeh
authors.forename: Feisal
authors.initials: F
authors.lastname: Rahat
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Khalili
authors.forename: Farzin
authors.initials: F
authors.lastname: Ahmadi
mesh_terms: D000388:Air; D000818:Animals; D000867:Anterior Chamber / Q000382:microbiology*; D004195:Disease Models, Animal; D009877:Endophthalmitis / Q000382:microbiology / Q000473:pathology / Q000517:prevention & control*; D011817:Rabbits; D012160:Retina / Q000473:pathology; D012173:Retinitis / Q000382:microbiology / Q000473:pathology / Q000517:prevention & control*; D013203:Staphylococcal Infections / Q000382:microbiology / Q000473:pathology / Q000517:prevention & control*; D013212:Staphylococcus epidermidis