title: Antifungal active triterpene glycosides from sea cucumber Holothuria scabra.
abstract: To study the new antifungal active triterpene glycosides of sea cucumber Holothuria scabra. Triterpene glycosides from Holothuria scabra were separated and purified by silica gel chromatography, reversed-phase silica gel chromatography and RP-HPLC. Their structures were elucidated on the basis of spectral data and chemical evidence. Three triterpene glycosides were identified as scabraside A (1), echinoidea A (2) and holothurin A1 (3). Scabraside A (1) is a new triterpene glycoside, and compounds 2 and 3 were isolated from Holothuria scabra for the first time. They showed antifungal activities (1 < or = MIC80 < or = 16 microg mL(-1)).
authors.affiliation: Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, Shanghai 200433, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Han
authors.forename: Yang-Hua
authors.initials: YH
authors.lastname: Yi
authors.forename: Ling
authors.initials: L
authors.lastname: Li
authors.forename: Bao-Shu
authors.initials: BS
authors.lastname: Liu
authors.forename: Ming-Ping
authors.initials: MP
authors.lastname: La
authors.forename: Hong-Wei
authors.initials: HW
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000302:isolation & purification* / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D047332:Holothuria / Q000737:chemistry*; D006697:Holothurin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000935:Antifungal Agents; D006027:Glycosides; D014315:Triterpenes; C562261:echinoidea A; C562260:holothurin A1; C548771:scabraside A; D006697:Holothurin