title: The pilot phase of the NIH Chemical Genomics Center.
abstract: The NIH Chemical Genomics Center (NCGC) was the inaugural center of the Molecular Libraries and Screening Center Network (MLSCN). Along with the nine other research centers of the MLSCN, the NCGC was established with a primary goal of bringing industrial technology and experience to empower the scientific community with small molecule compounds for use in their research. We intend this review to serve as 1) an introduction to the NCGC standard operating procedures, 2) an overview of several of the lessons learned during the pilot phase and 3) a review of several of the innovative discoveries reported during the pilot phase of the MLSCN.
authors.affiliation: NIH Chemical Genomics Center, NHGRI, National Institutes of Health, 9800 Medical Center Drive, Building B, Room 3005, MSC: 3370, Bethesda, MD 20892-3370, USA. craigt@nhgri.nih.gov
authors.forename: Craig J
authors.initials: CJ
authors.lastname: Thomas
authors.forename: Douglas S
authors.initials: DS
authors.lastname: Auld
authors.forename: Ruili
authors.initials: R
authors.lastname: Huang
authors.forename: Wenwei
authors.initials: W
authors.lastname: Huang
authors.forename: Ajit
authors.initials: A
authors.lastname: Jadhav
authors.forename: Ronald L
authors.initials: RL
authors.lastname: Johnson
authors.forename: William
authors.initials: W
authors.lastname: Leister
authors.forename: David J
authors.initials: DJ
authors.lastname: Maloney
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Marugan
authors.forename: Sam
authors.initials: S
authors.lastname: Michael
authors.forename: Anton
authors.initials: A
authors.lastname: Simeonov
authors.forename: Noel
authors.initials: N
authors.lastname: Southall
authors.forename: Menghang
authors.initials: M
authors.lastname: Xia
authors.forename: Wei
authors.initials: W
authors.lastname: Zheng
authors.forename: James
authors.initials: J
authors.lastname: Inglese
authors.forename: Christopher P
authors.initials: CP
authors.lastname: Austin
mesh_terms: D002626:Chemistry, Pharmaceutical; D004353:Drug Evaluation, Preclinical; D023281:Genomics; D057166:High-Throughput Screening Assays; D009316:National Institutes of Health (U.S.); D010865:Pilot Projects; D054852:Small Molecule Libraries; D014481:United States
chemical_list: D054852:Small Molecule Libraries