title: Influence of smoking on outcome of COH and IUI in subfertile couples.
abstract: OBJECTIVE
  To evaluate the influence of smoking on the outcome of COH and IUI in subfertile couples.
  
  
  METHODS
  We reviewed the medical files of all consecutive women, age </=35 years, attending our infertility clinics over an eigth-year period. Data on patient age, smoking habits, and variable related to infertility-treatment were collected from the files.
  
  
  RESULTS
  A total of 2,318 cases were evaluated: 1,803 in nonsmoking patients (n = 679) and 515 in smokers (n = 206). The smokers used significantly more gonadotropin ampoules and gained a thinner endometrium on the day of hCG administration than the nonsmokers (p < 0.016 for both). There were no between-groups differences in patient age, duration of gonadotropin stimulation, number of follicle >14 mm in diameter, or E2 levels on the day of hCG administration.
  
  
  CONCLUSIONS
  Smokers undergoing COH with IUI required a significantly higher gonadotropin dosage than nonsmokers in order to achieved a comparable pregnancy rate.
authors.affiliation: Fertility Clinics, Ashdod and Holon Women's Health Centers, Clalit Medical Services, Tel Aviv, Israel. j_farhi@yahoo.com
authors.forename: Jacob
authors.initials: J
authors.lastname: Farhi
authors.forename: Raoul
authors.initials: R
authors.lastname: Orvieto
mesh_terms: D000328:Adult; D004305:Dose-Response Relationship, Drug; D005260:Female; D006062:Gonadotropins / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007315:Insemination, Artificial; D010062:Ovulation Induction; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D012907:Smoking / Q000009:adverse effects*; D016896:Treatment Outcome
chemical_list: D006062:Gonadotropins