title: A new wrinkle in the fold: hepcidin links inflammation to the unfolded protein response.
abstract: The unfolded protein response (UPR) coordinates translational and transcriptional changes triggered by unfolded proteins within the endoplasmic reticulum. Two recent papers (Oliveira et al., 2009; Vecchi et al., 2009) show that the UPR modulates transcription of the hormone hepcidin, which controls plasma iron levels and perhaps innate immunity.
authors.affiliation: Department of Internal Medicine, University of Utah, Salt Lake City, UT 84132, USA.
authors.forename: Ivana
authors.initials: I
authors.lastname: De Domenico
authors.forename: Jerry
authors.initials: J
authors.lastname: Kaplan
mesh_terms: D000818:Animals; D023181:Antimicrobial Cationic Peptides / Q000235:genetics / Q000378:metabolism*; D017362:Cyclic AMP Response Element-Binding Protein / Q000235:genetics / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000378:metabolism; D015966:Gene Expression Regulation, Fungal; D064451:Hepcidins; D007249:Inflammation / Q000378:metabolism*; D051379:Mice; D015398:Signal Transduction / Q000502:physiology; D056811:Unfolded Protein Response / Q000502:physiology*
chemical_list: D023181:Antimicrobial Cationic Peptides; C500051:Creb3l3 protein, mouse; D017362:Cyclic AMP Response Element-Binding Protein; C579599:Hamp protein, mouse; D064451:Hepcidins