title: Asymptomatic ventricular preexcitation: a long-term prospective follow-up study of 293 adult patients.
abstract: BACKGROUND
  Sudden cardiac death can be the first clinical presentation of asymptomatic ventricular preexcitation.
  
  
  RESULTS
  From 1995 to 2005, we prospectively collected clinical and electrophysiological data among 293 adults with asymptomatic ventricular preexcitation (61.4% males; median age, 36 years; interquartile range [IQR], 28 to 47.5). After electrophysiological testing, patients were prospectively followed, taking no drugs. The primary end point of the study was the occurrence of a first arrhythmic event. Predictors of arrhythmic events were analyzed by univariate and multivariate Cox models. Over a median follow-up of 67 months (minimum to maximum, 8 to 90), after electrophysiological testing, 262 patients (median age, 37 years; IQR, 30 to 48) did not experience arrhythmic events, remaining totally asymptomatic, whereas 31 patients (median age, 25 years; IQR, 22 to 29; median follow-up, 27 months; minimum to maximum, 8 to 55) had a first arrhythmic event, which was potentially life-threatening in 17 of them (median age, 24 years; IQR, 20 to 28.5; median follow-up, 25 months; minimum to maximum, 9 to 55). Potentially life-threatening tachyarrhythmias resulted in resuscitated cardiac arrest (1 patient), presyncope (7 patients) syncope (4 patients), or dizziness (5 patients). In multivariate analysis age (P=0.004), inducibility (P=0.001) and anterograde effective refractory period of the accessory pathway < or = 250 ms (P=0.001) predicted potentially life-threatening arrhythmias.
  
  
  CONCLUSIONS
  These results indicate that prognosis of adults who present with asymptomatic ventricular preexcitation is good, and the risk of a significant event is small. Short anterograde effective refractory period of the accessory pathway and inducibility at baseline are independent predictors of potentially life-threatening arrhythmic events, and the risk decreases with increasing age.
authors.affiliation: Department of Arrhythmology, Electrophysiology, and Cardiac Pacing Unit, San Raffaele Scientific Institute, 20132 Milan, Italy. vincenzo.santinelli@hsr.it
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Santinelli
authors.forename: Andrea
authors.initials: A
authors.lastname: Radinovic
authors.forename: Francesco
authors.initials: F
authors.lastname: Manguso
authors.forename: Gabriele
authors.initials: G
authors.lastname: Vicedomini
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Ciconte
authors.forename: Simone
authors.initials: S
authors.lastname: Gulletta
authors.forename: Gabriele
authors.initials: G
authors.lastname: Paglino
authors.forename: Stefania
authors.initials: S
authors.lastname: Sacchi
authors.forename: Simone
authors.initials: S
authors.lastname: Sala
authors.forename: Cristiano
authors.initials: C
authors.lastname: Ciaccio
authors.forename: Carlo
authors.initials: C
authors.lastname: Pappone
mesh_terms: D000328:Adult; D017115:Catheter Ablation; D016757:Death, Sudden, Cardiac / Q000453:epidemiology* / Q000517:prevention & control*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012032:Refractory Period, Electrophysiological / Q000502:physiology; D012307:Risk Factors; D014927:Wolff-Parkinson-White Syndrome / Q000401:mortality* / Q000503:physiopathology* / Q000601:surgery; D055815:Young Adult