title: Refractory urinary tract and vulvovaginal infection caused by Candida krusei.
abstract: Candida krusei is an uncommon cause of vaginitis and cystitis but is unique because of the management challenge it poses due to intrinsic resistance to fluconazole and flucytosine. We report a case of C. krusei vaginitis and cystitis successfully managed with topical vaginal and intravesical amphotericin B. The challenges in managing C. krusei cystitis and the role of amphotericin B bladder irrigation in the management of fungal urinary tract infections are discussed.
authors.affiliation: Division of Infectious Diseases, Wayne State University School of Medicine, Detroit, MI 48201, USA.
authors.forename: Geetha
authors.initials: G
authors.lastname: Sivasubramanian
authors.forename: J D
authors.initials: JD
authors.lastname: Sobel
mesh_terms: D000287:Administration, Topical; D000666:Amphotericin B / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D002175:Candida / Q000187:drug effects / Q000502:physiology*; D002181:Candidiasis, Vulvovaginal / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D025141:Drug Resistance, Fungal / Q000187:drug effects / Q000502:physiology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D016896:Treatment Outcome; D014552:Urinary Tract Infections / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B