Type I and type II pathways of Fas-mediated apoptosis are differentially controlled by XIAP.
The mechanism by which Fas activates the apoptotic pathway differs in so-called type I and type II cells. X chromosome-linked inhibitor of apoptosis protein has now been revealed as an important molecule that is differentially regulated in type I vs. type II cells.
Hao
Zhenyue
Z
The Campbell Family Cancer Research Institute, University Health Network, Toronto, ON, Canada. yhao@uhnres.utoronto.ca
Mak
Tak W
TW
D000818:Animals; D017209:Apoptosis; D051379:Mice; D018345:Mice, Knockout; D015398:Signal Transduction; D051636:X-Linked Inhibitor of Apoptosis Protein / Q000378:metabolism*; D019014:fas Receptor / Q000378:metabolism*
C491899:Fas protein, mouse; D051636:X-Linked Inhibitor of Apoptosis Protein; D019014:fas Receptor