Cutaneous vasculitis associated with interferon beta-1b treatment for multiple sclerosis.
We report a 38-year-old woman with relapsing-remitting multiple sclerosis, treated with subcutaneous injections of interferon beta (IFN-beta)-1b every other day. Disseminated cutaneous lesions were observed after 3 injections. These symptoms reappeared after drug readministration. The histopathological examination of the skin specimens confirmed nonspecific cutaneous lymphocytic vasculitis. The patient's outcome was favorable after corticosteroid placement and discontinuing IFN-beta therapy. Isolated lymphocytic cutaneous vasculitis linked to IFN-beta-1b therapy is suspected as a new association.
Szilasiová
Jarmila
J
Department of Neurology, Faculty of Medicine, Safarik University, Kosice, Slovakia. jarmila.szilasiova@upjs.sk
Gdovinová
Zuzana
Z
Jautová
Jagienka
J
Baloghová
Janette
J
Ficová
Marta
M
Bohus
Peter
P
D000328:Adult; D005260:Female; D006801:Humans; D000068576:Interferon beta-1b; D016899:Interferon-beta / Q000009:adverse effects*; D009103:Multiple Sclerosis / Q000188:drug therapy* / Q000473:pathology; D016896:Treatment Outcome; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000139:chemically induced* / Q000175:diagnosis* / Q000473:pathology
D000068576:Interferon beta-1b; D016899:Interferon-beta