Haemorrhagic transformation of cerebral infarction in an AIDS patient--thrombophilia screen essential!
Patients with advanced HIV disease with low CD4 count are more prone to thrombo-embolism and various predisposing factors have been identified. These include the presence of anticardiolipin antibodies and the lupus anticoagulant, deficiencies of proteins C and S, heparin co-factor II and antithrombin. Increased levels of Von Willebrand factor and d-dimers have also been linked with thrombo-embolism, as has the presence of concurrent infections and malignancies. We report a case of an AIDS patient who presented with acute hemiparesis. He was severely immunosuppressed. Computed tomography of the head confirmed cerebral infarction with haemorrhagic transformation. He had no known risk factors apart from being severely immunocompromised and had high anticardiolipin antibodies and low free protein S.
Yoganathan
K
K
Department of Genitourinary Medicine, ABM University NHS Trust, Singleton Hospital, Sketty, Swansea, UK. kathir.yoganathan@swansea-tr.wales.nhs.uk
Benton
A
A
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000276:immunology; D000328:Adult; D017153:Antibodies, Anticardiolipin / Q000097:blood; D002543:Cerebral Hemorrhage / Q000097:blood / Q000000981:diagnostic imaging / Q000209:etiology*; D002544:Cerebral Infarction / Q000097:blood / Q000000981:diagnostic imaging / Q000209:etiology*; D006801:Humans; D016867:Immunocompromised Host; D008297:Male; D010291:Paresis / Q000097:blood / Q000000981:diagnostic imaging / Q000209:etiology; D018455:Protein S Deficiency / Q000175:diagnosis* / Q000209:etiology*; D012307:Risk Factors; D014057:Tomography, X-Ray Computed
D017153:Antibodies, Anticardiolipin