Epidermal growth factor receptors, testosterone levels and parotid gland changes in rats infected with Trypanosoma cruzi.
It has been demonstrated that parotid glands of rats infected with Trypanosoma cruzi present severe histological alterations; changes include reduction in density and volume of the acini and duct systems and an increase in connective tissue. We evaluated the association between morphological changes in parotid glands, circulating testosterone levels and epidermal growth factor receptor (EGF-R) expression in experimental Chagas disease in rats. Animals at 18 days of infection (acute phase) showed a significant decrease in body weight, serum testosterone levels and EGF-R expression in the parotid gland compared with a control group. Since decreases in body weight could lead to a reduction in circulating testosterone concentration, we believe that the reduction in EGF-R expression in parotid glands of infected rats is due to alterations in testosterone levels and atrophy of parotid glands is caused by changes in EGF-R expression. Additionally, at 50 days (chronic phase) of infection parotid glands showed a normal histological aspect likely due to the normalization of the body weight. These findings suggest that the testosterone-EGF-R axis is involved in the histological changes.
Aguirre
Kezia L H
KL
Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Av. Antônio Carlos 6627, Belo Horizonte, MG, Brazil.
Alves
José B
JB
Silva
Gerluza A B
GA
Cardoso
Jarbas E
JE
Murta
Silvane M F
SM
Ferreira
Anderson J
AJ
D000208:Acute Disease; D000818:Animals; D014355:Chagas Disease / Q000378:metabolism / Q000473:pathology; D002908:Chronic Disease; D004815:Epidermal Growth Factor / Q000032:analysis / Q000378:metabolism*; D008297:Male; D010306:Parotid Gland / Q000737:chemistry* / Q000378:metabolism / Q000469:parasitology / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013739:Testosterone / Q000097:blood / Q000378:metabolism*; D013997:Time Factors; D014349:Trypanosoma cruzi; D015431:Weight Loss
D013739:Testosterone; D004815:Epidermal Growth Factor