B cell activation versus anergy; the antigen receptor as a molecular switch.
Anergic B cells are autoreactive and are present in the periphery in an unresponsive state. Here we will discuss the difference in B cell receptor signaling between anergic B cells, chronically stimulated by autoantigen, and naïve B cell encountering antigen.
Cambier
John C
JC
Department of Immunology, University of Colorado Denver School of Medicine and National Jewish Medical and Research Center, 1400 Jackson Street, K803 Denver, CO 80206, USA. cambierj@njc.org
Getahun
Andy
A
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D017635:Clonal Anergy; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism; D008213:Lymphocyte Activation; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D020239:Receptor Cross-Talk / Q000276:immunology; D011947:Receptors, Antigen, B-Cell / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology; D000072377:Syk Kinase; D019061:src-Family Kinases / Q000378:metabolism
D047908:Intracellular Signaling Peptides and Proteins; D011947:Receptors, Antigen, B-Cell; D011505:Protein-Tyrosine Kinases; C000606896:SYK protein, human; D000072377:Syk Kinase; C060902:lyn protein-tyrosine kinase; D019061:src-Family Kinases