title: Collaborative Depression Trial (CADET): multi-centre randomised controlled trial of collaborative care for depression--study protocol.
abstract: BACKGROUND
  Comprising of both organisational and patient level components, collaborative care is a potentially powerful intervention for improving depression treatment in UK primary Care. However, as previous models have been developed and evaluated in the United States, it is necessary to establish the effect of collaborative care in the UK in order to determine whether this innovative treatment model can replicate benefits for patients outside the US. This Phase III trial was preceded by a Phase II patient level RCT, following the MRC Complex Intervention Framework.
  
  
  METHODS
  A multi-centre controlled trial with cluster-randomised allocation of GP practices. GP practices will be randomised to usual care control or to "collaborative care" - a combination of case manager coordinated support and brief psychological treatment, enhanced specialist and GP communication. The primary outcome will be symptoms of depression as assessed by the PHQ-9.
  
  
  CONCLUSIONS
  If collaborative care is demonstrated to be effective we will have evidence to enable the NHS to substantially improve the organisation of depressed patients in primary care, and to assist primary care providers to deliver a model of enhanced depression care which is both effective and acceptable to patients.
authors.affiliation: Mood Disorders Centre, School of Psychology, University of Exeter, EX4 4QG, UK. d.a.richards@exeter.ac.uk
authors.forename: David A
authors.initials: DA
authors.lastname: Richards
authors.forename: Adwoa
authors.initials: A
authors.lastname: Hughes-Morley
authors.forename: Rachel A
authors.initials: RA
authors.lastname: Hayes
authors.forename: Ricardo
authors.initials: R
authors.lastname: Araya
authors.forename: Michael
authors.initials: M
authors.lastname: Barkham
authors.forename: John M
authors.initials: JM
authors.lastname: Bland
authors.forename: Peter
authors.initials: P
authors.lastname: Bower
authors.forename: John
authors.initials: J
authors.lastname: Cape
authors.forename: Carolyn A
authors.initials: CA
authors.lastname: Chew-Graham
authors.forename: Linda
authors.initials: L
authors.lastname: Gask
authors.forename: Simon
authors.initials: S
authors.lastname: Gilbody
authors.forename: Colin
authors.initials: C
authors.lastname: Green
authors.forename: David
authors.initials: D
authors.lastname: Kessler
authors.forename: Glyn
authors.initials: G
authors.lastname: Lewis
authors.forename: Karina
authors.initials: K
authors.lastname: Lovell
authors.forename: Chris
authors.initials: C
authors.lastname: Manning
authors.forename: Stephen
authors.initials: S
authors.lastname: Pilling
mesh_terms: D019090:Case Management; D003299:Cooperative Behavior; D003362:Cost-Benefit Analysis; D003866:Depressive Disorder / Q000628:therapy*; D005194:Family Practice; D005260:Female; D006801:Humans; D008297:Male; D018802:Patient-Centered Care; D011320:Primary Health Care / Q000191:economics / Q000458:organization & administration*; D016032:Randomized Controlled Trials as Topic / Q000379:methods; D006113:United Kingdom