title: PKMzeta maintains 1-day- and 6-day-old long-term object location but not object identity memory in dorsal hippocampus.
abstract: Continuous activity of the atypical protein kinase C isoform M zeta (PKMzeta) is necessary for maintaining long-term memory acquired in aversively or appetitively motivated associative learning tasks, such as active avoidance, aversive taste conditioning, auditory and contextual fear conditioning, radial arm maze, and watermaze. Whether unreinforced, nonassociative memory will also require PKMzeta for long-term maintenance is not known. Using recognition memory for object location and object identity, we found that inactivating PKMzeta in dorsal hippocampus abolishes 1-day and 6-day-old long-term recognition memory for object location, while recognition memory for object identity was not affected by this treatment. Memory for object location persisted for no more than 35 days after training. These results suggest that the dorsal hippocampus mediates long-term memory for where, but not what things have been encountered, and that PKMzeta maintains this type of spatial knowledge as long as the memory exists.
authors.affiliation: Department of Psychology, McGill University, Montreal, Quebec, Canada. oliver.hardt@mac.com
authors.forename: Oliver
authors.initials: O
authors.lastname: Hardt
authors.forename: Paola V
authors.initials: PV
authors.lastname: Migues
authors.forename: Margaret
authors.initials: M
authors.lastname: Hastings
authors.forename: Jacinda
authors.initials: J
authors.lastname: Wong
authors.forename: Karim
authors.initials: K
authors.lastname: Nader
mesh_terms: D000818:Animals; D003214:Conditioning, Classical / Q000502:physiology; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism*; D008568:Memory / Q000187:drug effects / Q000502:physiology*; D011493:Protein Kinase C / Q000378:metabolism*; D051381:Rats; D000099221:Protein Kinase C zeta
chemical_list: D004791:Enzyme Inhibitors; D011493:Protein Kinase C; D000099221:Protein Kinase C zeta