Immune response and viral persistence in Indian buffaloes (Bubalus bubalis) infected with foot-and-mouth disease virus serotype Asia 1.
Despite their potential role in the spread of foot-and-mouth disease (FMD), the immune response and viral persistence in FMD virus (FMDV)-infected Indian buffaloes (Bubalus bubalis) have been unexplored. We found similar kinetics of neutralizing antibody responses in the sera and secretory fluids of buffaloes following experimental FMDV Asia 1 infection, but the lymphocyte-proliferative response in infected buffaloes was of low magnitude. Despite inducing a significant systemic and secretory immune response, viral persistence seems to be a common outcome in buffaloes following FMDV Asia 1 infection, which is associated with a weak cellular immune response.
Maddur
Mohan S
MS
Indian Veterinary Research Institute, Bellary Road, Hebbal, Bangalore 560024, Karanataka, India. mohanms.manu@gmail.com
Kishore
Subodh
S
Gopalakrishna
S
S
Singh
Nem
N
Suryanarayana
V V
VV
Gajendragad
Mukund R
MR
D000818:Animals; D057134:Antibodies, Neutralizing / Q000097:blood / Q000276:immunology*; D001826:Body Fluids / Q000276:immunology / Q000821:virology; D002020:Buffaloes / Q000276:immunology / Q000821:virology*; D003208:Concanavalin A / Q000494:pharmacology; D005536:Foot-and-Mouth Disease / Q000276:immunology* / Q000821:virology; D029544:Foot-and-Mouth Disease Virus / Q000276:immunology*; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000276:immunology / Q000821:virology; D008934:Mitogens / Q000494:pharmacology
D057134:Antibodies, Neutralizing; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D008934:Mitogens; D003208:Concanavalin A