title: A multicentre, observational study of sodium picosulfate and magnesium citrate as a precolonoscopy bowel preparation.
abstract: BACKGROUND
  Sodium picosulfate with magnesium citrate (PSMC) has been available as a precolonoscopy bowel preparation in Canada since 2005. A high patient acceptability and preference appears to have contributed to its wide adoption across the country. Despite its frequent use, there are relatively few published studies of this product, especially reports regarding its use in routine clinical practice. Moreover, to date, there have been no Canadian studies of any kind.
  
  
  OBJECTIVE
  To conduct a preliminary evaluation of PSMC by prospectively collecting data describing its effectiveness.
  
  
  METHODS
  In the present multicentre, observational study, sequential patients used PSMC according to each institution's standard colonoscopy protocol. Differences in bowel cleansing protocols included dose timing, fluid intake, dietary restrictions and administration of bisacodyl. During colonoscopy, preparation quality was rated separately for the right and left sides of the colon.
  
  
  RESULTS
  Of the 613 patients entered, 606 were evaluable for efficacy. For the right and left colon, respectively, 93.0% and 96.2% of preparations were rated either 'excellent' or 'adequate'. In the 334 patients who received adjunctive bisacodyl and the 272 patients who did not, the results were similar: for the right and left colon, 92.3% and 97.1% of those who did not, and 93.4% and 95.7% of those who did receive bisacodyl, respectively, were rated either 'excellent' or 'adequate'.
  
  
  CONCLUSIONS
  Despite the differences in bowel cleansing protocols used at each hospital (including an additional laxative), PSMC consistently yielded a high percentage of positive ratings for efficacy.
authors.affiliation: Foothills Medical Centre, Calgary, Alberta. jlove@ucalgary.ca
authors.forename: Jonthan
authors.initials: J
authors.lastname: Love
authors.forename: Edmond-Jean
authors.initials: EJ
authors.lastname: Bernard
authors.forename: Alan
authors.initials: A
authors.lastname: Cockeram
authors.forename: Lawrence
authors.initials: L
authors.lastname: Cohen
authors.forename: Martin
authors.initials: M
authors.lastname: Fishman
authors.forename: James
authors.initials: J
authors.lastname: Gray
authors.forename: David
authors.initials: D
authors.lastname: Morgan
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001726:Bisacodyl / Q000008:administration & dosage; D002400:Cathartics / Q000008:administration & dosage*; D002951:Citrates; D019343:Citric Acid / Q000008:administration & dosage*; D003113:Colonoscopy / Q000379:methods; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds / Q000008:administration & dosage*; D010847:Picolines / Q000008:administration & dosage*; D011300:Preoperative Care; D055815:Young Adult
chemical_list: D002400:Cathartics; D002951:Citrates; D004338:Drug Combinations; D009942:Organometallic Compounds; D010847:Picolines; D001726:Bisacodyl; D019343:Citric Acid; C005701:picosulfate sodium; C110422:magnesium citrate