title: Hypothyroidism induced by polychlorinated biphenyls and up-regulation of transthyretin.
abstract: Polychlorinated biphenyls are environmental pollutants that are toxic to many biological systems. This study examined whether or not PCB126 and PCB114 have adverse effects on the serum thyroxine level and the serum proteome in rats. The results showed a lower serum total thyroxine level in the PCB126 and PCB114-treated groups than the control. Western blotting showed that the levels of transthyretin expression were significantly higher in the PCB-treated group than the control group. These results suggest that the PCB-mediated hypothyroidism is caused by the displacement of thyroxine from transthyretin.
authors.affiliation: Research Institute of Life Science, Gyeongsang National University, Jinju, 660-701, Korea.
authors.forename: Dae-Yong
authors.initials: DY
authors.lastname: Han
authors.forename: Sang-Rim
authors.initials: SR
authors.lastname: Kang
authors.forename: Oh-Sung
authors.initials: OS
authors.lastname: Park
authors.forename: Jae-Hyeon
authors.initials: JH
authors.lastname: Cho
authors.forename: Chung-Kil
authors.initials: CK
authors.lastname: Won
authors.forename: Hyeon-Soo
authors.initials: HS
authors.lastname: Park
authors.forename: Kwang-Il
authors.initials: KI
authors.lastname: Park
authors.forename: Eun-Hee
authors.initials: EH
authors.lastname: Kim
authors.forename: Gon-Sup
authors.initials: GS
authors.lastname: Kim
mesh_terms: D000818:Animals; D007037:Hypothyroidism / Q000139:chemically induced*; D008297:Male; D011078:Polychlorinated Biphenyls / Q000633:toxicity*; D011228:Prealbumin / Q000235:genetics / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013974:Thyroxine / Q000097:blood; D015854:Up-Regulation / Q000187:drug effects*
chemical_list: D011228:Prealbumin; C035834:2,3,4,4'5-pentachlorobiphenyl; D011078:Polychlorinated Biphenyls; D013974:Thyroxine; C023035:3,4,5,3',4'-pentachlorobiphenyl