title: Patterns of neurovascular compression in patients with classic trigeminal neuralgia: A high-resolution MRI-based study.
abstract: OBJECTIVE
  To describe the anatomical characteristics and patterns of neurovascular compression in patients suffering classic trigeminal neuralgia (CTN), using high-resolution magnetic resonance imaging (MRI).
  
  
  METHODS
  The analysis of the anatomy of the trigeminal nerve, brain stem and the vascular structures related to this nerve was made in 100 consecutive patients treated with a Gamma Knife radiosurgery for CTN between December 1999 and September 2004. MRI studies (T1, T1 enhanced and T2-SPIR) with axial, coronal and sagital simultaneous visualization were dynamically assessed using the software GammaPlan™. Three-dimensional reconstructions were also developed in some representative cases.
  
  
  RESULTS
  In 93 patients (93%), there were one or several vascular structures in contact, either, with the trigeminal nerve, or close to its origin in the pons. The superior cerebellar artery was involved in 71 cases (76%). Other vessels identified were the antero-inferior cerebellar artery, the basilar artery, the vertebral artery, and some venous structures. Vascular compression was found anywhere along the trigeminal nerve. The mean distance between the nerve compression and the origin of the nerve in the brainstem was 3.76±2.9mm (range 0-9.8mm). In 39 patients (42%), the vascular compression was located proximally and in 42 (45%) the compression was located distally. Nerve dislocation or distortion by the vessel was observed in 30 cases (32%).
  
  
  CONCLUSIONS
  The findings of this study are similar to those reported in surgical and autopsy series. This non-invasive MRI-based approach could be useful for diagnostic and therapeutic decisions in CTN, and it could help to understand its pathogenesis.
authors.affiliation: Department of Neurosurgery, School of Medicine, Pontificia Universidad Católica de Chile, Chile. jls@med.puc.cl
authors.forename: José
authors.initials: J
authors.lastname: Lorenzoni
authors.forename: Philippe
authors.initials: P
authors.lastname: David
authors.forename: Marc
authors.initials: M
authors.lastname: Levivier
mesh_terms: D000328:Adult; D000368:Aged; D002561:Cerebrovascular Disorders / Q000209:etiology* / Q000473:pathology*; D003251:Constriction, Pathologic; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009408:Nerve Compression Syndromes / Q000209:etiology* / Q000473:pathology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014277:Trigeminal Neuralgia / Q000150:complications* / Q000473:pathology*; D055815:Young Adult