Ferrying wingless across the synaptic cleft.
Secreted Wnt morphogens mediate cell-cell communication, but the mechanism of Wnt transfer between cells is unknown. Korkut et al. (2009) report that the transmembrane protein Evi is a versatile carrier that guides Wingless to presynaptic terminals of motor neurons and then escorts it across the synaptic cleft. In postsynaptic muscles, Evi promotes Frizzled-2 trafficking.
Zarnescu
Daniela C
DC
Department of Molecular and Cellular Biology, University of Arizona, Tucson, AZ 85721, USA.
Zinsmaier
Konrad E
KE
D000818:Animals; D004330:Drosophila / Q000378:metabolism*; D029721:Drosophila Proteins / Q000378:metabolism; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism; D021381:Protein Transport; D013569:Synapses; D051155:Wnt1 Protein / Q000378:metabolism
D029721:Drosophila Proteins; D047908:Intracellular Signaling Peptides and Proteins; C511046:Wls protein, Drosophila; D051155:Wnt1 Protein; C074622:wg protein, Drosophila