title: The first transannular [4+3] cycloaddition reaction: synthesis of the ABCD ring structure of cortistatins.
abstract: A 14-membered macrocycle with an allene and a furan strategically located at across the ring from each other is synthesized using an allene ring closing metathesis reaction. Upon treatment of the macrocycle with a catalytic amount of Pd(OAc)(2) and other additives, the first transannular [4+3] cycloaddition occurred to yield 37% of a tetracyclic compound containing the ABC ring structure of the natural products cortistatins.
authors.affiliation: Department of Chemistry and Biochemistry, Miami University Oxford, OH 45056.
authors.forename: Derek T
authors.initials: DT
authors.lastname: Craft
authors.forename: Benjamin W
authors.initials: BW
authors.lastname: Gung