Long-term suppression of GABAergic activity by neonatal seizures in rat somatosensory cortex.
Here we studied the long-term effects of neonatal seizures on inhibitory synaptic transmission in somatosensory cortex. We found that recurrent flurothyl-induced seizures result in a marked reduction in amplitude of spontaneous inhibitory postsynaptic currents (IPSCs) and increases of miniature IPSCs interevent intervals. These results indicate that decreasing the inhibitory synaptic strength following neonatal seizures in neocortical neurons is not due to a postsynaptic mechanism.
Isaeva
Elena
E
Department of Neurology, Neuroscience Center at Dartmouth, Dartmouth Medical School, Lebanon, NH, USA. olena.isaeva@gmail.com
Isaev
Dmytro
D
Khazipov
Rustem
R
Holmes
Gregory L
GL
D000818:Animals; D000831:Animals, Newborn; D005481:Flurothyl / Q000633:toxicity; D053444:Inhibitory Postsynaptic Potentials / Q000502:physiology*; D055369:Miniature Postsynaptic Potentials / Q000502:physiology*; D009433:Neural Inhibition / Q000502:physiology; D009474:Neurons / Q000378:metabolism / Q000502:physiology*; D018408:Patch-Clamp Techniques; D051381:Rats; D017207:Rats, Sprague-Dawley; D012640:Seizures / Q000139:chemically induced / Q000378:metabolism / Q000503:physiopathology*; D013003:Somatosensory Cortex / Q000378:metabolism / Q000503:physiopathology*; D009435:Synaptic Transmission / Q000502:physiology; D013995:Time; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D005680:gamma-Aminobutyric Acid; D005481:Flurothyl