title: Anti-leishmanial lindenane sesquiterpenes from Hedyosmum angustifolium.
abstract: The aim of this work is the isolation of anti-leishmanial compounds from the ethyl acetate extracts of the bark of HEDYOSMUM ANGUSTIFOLIUM. We have successfully isolated and characterized five sesquiterpenes: one new compound (oxyonoseriolide, 1), one compound isolated for the first time from a natural source (hedyosmone, 2), and three known sesquiterpenes (onoseriolide, 3; chloranthalactone A, 4; and spathulenol, 5) that had not been previously isolated from H. ANGUSTIFOLIUM. The biological activities of 1- 5 showed that onoseriolide ( 3) was the most active compound against axenic amastigotes from LEISHMANIA AMAZONENSIS and L. INFANTUM. Moreover, it was still active on the intramacrophagic amastigotes of L. INFANTUM. The isolated compounds have also been tested on PLASMODIUM FALCIPARUM and against various mammalian cell lines.
authors.forename: Lucia
authors.initials: L
authors.lastname: Acebey
authors.forename: Valérie
authors.initials: V
authors.lastname: Jullian
authors.forename: Denis
authors.initials: D
authors.lastname: Sereno
authors.forename: Séverine
authors.initials: S
authors.lastname: Chevalley
authors.forename: Yannick
authors.initials: Y
authors.lastname: Estevez
authors.forename: Claude
authors.initials: C
authors.lastname: Moulis
authors.forename: Stephan
authors.initials: S
authors.lastname: Beck
authors.forename: Alex
authors.initials: A
authors.lastname: Valentin
authors.forename: Alberto
authors.initials: A
authors.lastname: Gimenez
authors.forename: Michel
authors.initials: M
authors.lastname: Sauvain
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000302:isolation & purification / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D002522:Chlorocebus aethiops; D006801:Humans; D007891:Leishmania / Q000187:drug effects*; D019684:Magnoliopsida / Q000737:chemistry*; D009369:Neoplasms / Q000188:drug therapy; D021261:Parasitic Sensitivity Tests; D024301:Plant Bark; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D010963:Plasmodium falciparum / Q000187:drug effects*; D012717:Sesquiterpenes / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D014344:Trypanocidal Agents / Q000302:isolation & purification / Q000494:pharmacology*; D014709:Vero Cells
chemical_list: D000962:Antimalarials; D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D012717:Sesquiterpenes; D014344:Trypanocidal Agents; C551646:onoseriolide