title: Text mining and manual curation of chemical-gene-disease networks for the comparative toxicogenomics database (CTD).
abstract: BACKGROUND
  The Comparative Toxicogenomics Database (CTD) is a publicly available resource that promotes understanding about the etiology of environmental diseases. It provides manually curated chemical-gene/protein interactions and chemical- and gene-disease relationships from the peer-reviewed, published literature. The goals of the research reported here were to establish a baseline analysis of current CTD curation, develop a text-mining prototype from readily available open source components, and evaluate its potential value in augmenting curation efficiency and increasing data coverage.
  
  
  RESULTS
  Prototype text-mining applications were developed and evaluated using a CTD data set consisting of manually curated molecular interactions and relationships from 1,600 documents. Preliminary results indicated that the prototype found 80% of the gene, chemical, and disease terms appearing in curated interactions. These terms were used to re-rank documents for curation, resulting in increases in mean average precision (63% for the baseline vs. 73% for a rule-based re-ranking), and in the correlation coefficient of rank vs. number of curatable interactions per document (baseline 0.14 vs. 0.38 for the rule-based re-ranking).
  
  
  CONCLUSIONS
  This text-mining project is unique in its integration of existing tools into a single workflow with direct application to CTD. We performed a baseline assessment of the inter-curator consistency and coverage in CTD, which allowed us to measure the potential of these integrated tools to improve prioritization of journal articles for manual curation. Our study presents a feasible and cost-effective approach for developing a text mining solution to enhance manual curation throughput and efficiency.
authors.affiliation: Department of Bioinformatics, The Mount Desert Island Biological Laboratory, Salisbury Cove, ME, USA. twiegers@mdibl.org
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Wiegers
authors.forename: Allan Peter
authors.initials: AP
authors.lastname: Davis
authors.forename: K Bretonnel
authors.initials: KB
authors.lastname: Cohen
authors.forename: Lynette
authors.initials: L
authors.lastname: Hirschman
authors.forename: Carolyn J
authors.initials: CJ
authors.lastname: Mattingly
mesh_terms: D019295:Computational Biology / Q000379:methods*; D016208:Databases, Factual; D053263:Gene Regulatory Networks; D016247:Information Storage and Retrieval / Q000379:methods*; D043922:Toxicogenetics