Membrane microdomains and insulin resistance.
A new concept, that "metabolic disorders, such as type 2 diabetes, are membrane microdomain disorders caused by aberrant expression of gangliosides", has arisen. By examining this working hypothesis, we demonstrate the molecular pathogenesis of type 2 diabetes and insulin resistance focusing on the interaction between insulin receptor and gangliosides in microdomains and propose the new therapeutic strategy "membrane microdomain ortho-signaling therapy".
Inokuchi
Jin-ichi
J
Division of Glycopathology, Institute of Molecular Biomembranes and Glycobiology, Tohoku Pharmaceutical University, Aoba-ku, Sendai, Miyagi, Japan. jin@tohoku-pharm.ac.jp
D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D005679:G(M3) Ganglioside / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000502:physiology; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D021962:Membrane Microdomains / Q000473:pathology / Q000502:physiology*; D008659:Metabolic Diseases / Q000209:etiology / Q000473:pathology / Q000628:therapy; D008954:Models, Biological
D015415:Biomarkers; D005679:G(M3) Ganglioside