title: Arginine-pyrimidine conjugates with therapeutic and prophylactic activity in lethal bacterial infections.
abstract: Arginine-pyrimidine conjugates represent a novel class of compounds that exhibits therapeutic and prophylactic activity in lethal infections by Gram-positive and Gram-negative bacteria without showing antibacterial activity in vitro.
authors.affiliation: Medicinal Chemistry, Bayer Schering Pharma AG, D-42096 Wuppertal, Germany. dieter.haebich@bayerhealthcare.com
authors.forename: Dieter
authors.initials: D
authors.lastname: Haebich
authors.forename: Hein-Peter
authors.initials: HP
authors.lastname: Kroll
authors.forename: Hans-Georg
authors.initials: HG
authors.lastname: Lerchen
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001120:Arginine / Q000737:chemistry / Q000494:pharmacology*; D001424:Bacterial Infections / Q000188:drug therapy; D003428:Cross Infection / Q000188:drug therapy*; D004347:Drug Interactions; D024901:Drug Resistance, Multiple, Bacterial; D006090:Gram-Negative Bacteria / Q000187:drug effects; D016106:Methicillin Resistance; D051379:Mice; D008813:Mice, Inbred ICR; D008826:Microbial Sensitivity Tests; D011743:Pyrimidines / Q000737:chemistry / Q000494:pharmacology*; D013290:Streptococcal Infections / Q000188:drug therapy
chemical_list: D000900:Anti-Bacterial Agents; D011743:Pyrimidines; D001120:Arginine