[Drug interactions in geriatric medicine].
Drug interactions are often seen in elder patients due to polymedication. They can lead to unwanted side effects attended with unspecific symptoms such as vertigo, lateropulsion, fatigue or confusion. This can result in a prescribing cascade. Interactions can take place on all pharmacodynamic and pharmacokinetic levels, whereas the CYP enzyme-dependent metabolism seems to play a key role. The incidence of drug interactions is quite high and clinical relevant interactions are also not uncommon. Especially drugs with a low therapeutic index are more likely to be the target of clinical relevant interactions. However, most of the drug interactions can be managed by dose-reduction or by replacing one of the possibly interacting drugs. An important point is to remember the possibility of drug interactions.
Storka
Angela
A
Universitätsklinik für Klinische Pharmakologie, Medizinische Universität Wien, Wien, Austria.
Pleiner
Johannes
J
D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D003577:Cytochrome P-450 Enzyme System / Q000502:physiology; D003937:Diagnosis, Differential; D004347:Drug Interactions / Q000502:physiology*; D004359:Drug Therapy, Combination / Q000009:adverse effects*; D004361:Drug Tolerance / Q000502:physiology; D064420:Drug-Related Side Effects and Adverse Reactions / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D018565:Food-Drug Interactions; D005853:Geriatrics; D041743:Herb-Drug Interactions; D006801:Humans; D007527:Isoenzymes / Q000502:physiology; D008657:Metabolic Clearance Rate / Q000502:physiology; D010599:Pharmacokinetics; D019338:Polypharmacy
D007527:Isoenzymes; D003577:Cytochrome P-450 Enzyme System