Fundus autofluorescence patterns in eyes with primary intraocular lymphoma.
OBJECTIVE
To evaluate the fundus autofluorescence (FAF) patterns in the eyes with primary intraocular lymphomas (PIOLs).


METHODS
A review of the medical charts of four consecutive patients (five eyes) with PIOL who had been studied by FAF. A fundus camera was used to obtain the FAF images. Optical coherence tomography was also performed.


RESULTS
The ophthalmoscopically observed brown clumps on the surface of greasy yellowish masses beneath the retinal pigmented epithelium had a bright hyperfluorescence appearance by FAF. This FAF hyperfluorescence was completely reversed to hypofluorescence in the fluorescein angiograms. The diffuse infiltration of the cells making up the PIOL above the retinal pigmented epithelium was ophthalmoscopically observed as a retinal whitening and was hypofluorescent by FAF. These areas of hypofluorescence were also reversed to areas of hyperfluorescence in the fluorescein angiogram. Fundus autofluorescence clearly delineated the retinal pigmented epithelium atrophy, which developed after the spontaneous resolution of the PIOL as a hypoautofluorescent area.


CONCLUSIONS
Because FAF can reveal various findings of PIOLs, it can be used to differentiate the patients with PIOL from those with ocular inflammatory diseases. Although further studies are required to determine whether these findings are characteristic to PIOL, this noninvasive method can then lead to earlier diagnosis and treatment.
Ishida
Tomoka
T
Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan.
Ohno-Matsui
Kyoko
K
Kaneko
Yuh
Y
Tobita
Hideaki
H
Shimada
Noriaki
N
Takase
Hiroshi
H
Mochizuki
Manabu
M
D000368:Aged; D000369:Aged, 80 and over; D001284:Atrophy; D004396:Coloring Agents; D005260:Female; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D006801:Humans; D007208:Indocyanine Green; D008062:Lipofuscin / Q000378:metabolism; D016393:Lymphoma, B-Cell / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D019572:Retinal Neoplasms / Q000175:diagnosis*; D055213:Retinal Pigment Epithelium / Q000378:metabolism / Q000473:pathology*; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence
D004396:Coloring Agents; D008062:Lipofuscin; D007208:Indocyanine Green