title: Acute toxicity of Schizolobium parahyba aqueous extract in mice.
abstract: The herbal extract of Schizolobium parahyba leaves is used commonly in the Brazil central region to treat snakebites. This study evaluates the acute toxicological effects of Schizolobium parahyba aqueous extract in mice 24 h after intraperitoneal administration. Acute toxicity was evaluated using biochemical, hematological and histopathological assays. Alterations in the levels of transaminases, bilirubin, albumin and prothrombrin time were observed, and these are likely to occur due to hepatic injury, which was confirmed by light microscopy. Liver histopathological analysis revealed the presence of lymph plasmocitary inflammatory infiltrate, but no other histopathological alterations were observed in any of the other organs analysed. The data confirm the low toxicity of the extract of Schizolobium parahyba and provide a model for the selection of a dose that does not cause injuries in the organism.
authors.affiliation: Laboratório de Química de Proteínas e Produtos Naturais, Instituto de Genética e Bioquímica, Universidade Federal de Uberlândia, Uberlândia-MG, Brazil. mirianmmendes@yahoo.com.br
authors.forename: Mirian M
authors.initials: MM
authors.lastname: Mendes
authors.forename: Luis H F
authors.initials: LH
authors.lastname: Vale
authors.forename: Malson N
authors.initials: MN
authors.lastname: Lucena
authors.forename: Sâmela A P B
authors.initials: SA
authors.lastname: Vieira
authors.forename: Luiz Fernando M
authors.initials: LF
authors.lastname: Izidoro
authors.forename: Robson J O
authors.initials: RJ
authors.lastname: Junior
authors.forename: Andreimar M
authors.initials: AM
authors.lastname: Soares
authors.forename: Tânia M
authors.initials: TM
authors.lastname: Alcântara
authors.forename: Amélia
authors.initials: A
authors.lastname: Hamaguchi
authors.forename: Maria Inês
authors.initials: MI
authors.lastname: Homsi-Brandeburgo
authors.forename: Veridiana M
authors.initials: VM
authors.lastname: Rodrigues
mesh_terms: D000418:Albumins / Q000032:analysis; D000818:Animals; D001663:Bilirubin / Q000097:blood; D001786:Blood Glucose; D003404:Creatinine / Q000097:blood; D007887:Fabaceae / Q000633:toxicity*; D007668:Kidney / Q000503:physiopathology; D008099:Liver / Q000473:pathology; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000633:toxicity*; D018515:Plant Leaves / Q000737:chemistry / Q000633:toxicity; D023382:Toxicity Tests, Acute
chemical_list: D000418:Albumins; D001786:Blood Glucose; D010936:Plant Extracts; D003404:Creatinine; D001663:Bilirubin