title: Synthetic peptides containing a conserved sequence motif of the Id protein family modulate vascular smooth muscle cell phenotype.
abstract: Modulation of smooth muscle cells to a proliferating and migrating phenotype with downregulated alpha-actin expression is observed upon vascular lesion formation. The Id proteins (inhibitors of cell differentiation) play a role in the development of this phenotype. In contrast, synthetic peptides based on a conserved 11-residue Id sequence trigger the switch to a contractile phenotype that shows reduced cell growth and migration, increased expression of alpha-actin and decreased Id protein levels.
authors.affiliation: DISMAB-Dipartimento di Scienze Molecolari Applicate ai Biosistemi-Sez. Chimica Organica, Università degli Studi di Milano, I-20133 Milan, Italy.
authors.forename: Sara
authors.initials: S
authors.lastname: Pellegrino
authors.forename: Nicola
authors.initials: N
authors.lastname: Ferri
authors.forename: Noemi
authors.initials: N
authors.lastname: Colombo
authors.forename: Edoardo
authors.initials: E
authors.lastname: Cremona
authors.forename: Alberto
authors.initials: A
authors.lastname: Corsini
authors.forename: Roberto
authors.initials: R
authors.lastname: Fanelli
authors.forename: Maria Luisa
authors.initials: ML
authors.lastname: Gelmi
authors.forename: Chiara
authors.initials: C
authors.lastname: Cabrele
mesh_terms: D000199:Actins / Q000502:physiology; D020816:Amino Acid Motifs / Q000502:physiology*; D001013:Aorta, Thoracic; D002135:Calcium-Binding Proteins; D002454:Cell Differentiation / Q000502:physiology*; D049109:Cell Proliferation; D017124:Conserved Sequence / Q000502:physiology*; D004730:Endothelium, Vascular / Q000166:cytology; D051796:Inhibitor of Differentiation Proteins / Q000235:genetics / Q000502:physiology*; D009131:Muscle, Smooth, Vascular / Q000502:physiology*; D032389:Myocytes, Smooth Muscle / Q000166:cytology / Q000502:physiology; D009687:Nuclear Proteins; D010455:Peptides / Q000138:chemical synthesis / Q000502:physiology*; D010641:Phenotype; D011485:Protein Binding; D012097:Repressor Proteins
chemical_list: D000199:Actins; D002135:Calcium-Binding Proteins; D051796:Inhibitor of Differentiation Proteins; D009687:Nuclear Proteins; D010455:Peptides; D012097:Repressor Proteins