Promotion effect of norgalanthamine, a component of Crinum asiaticum, on hair growth.
This study was conducted to evaluate the effect of Crinum asiaticum, a plant native to Jeju Island, Korea, on the promotion of hair growth. When rat vibrissa follicles were treated with a 95% ethanol (EtOH) extract of C. asiaticum, the hair-fiber lengths of the vibrissa follicles increased significantly. In addition, after daily topical application of the EtOH extract of C. asiaticum onto the back of C57BL/6 mice, anagen progression of the hair shaft was induced. Moreover, the extract increased the proliferation of immortalized vibrissa dermal papilla cells. When the vibrissa follicles in the anagen phase were treated with the extract, immunohistochemical analysis revealed that the extract was found to increase the expression of proliferating cell nuclear antigen (PCNA) in the bulb region of the 7-day cultured follicles. In particular, norgalanthamine, a principal of the extract, showed activity that increased the hair-fiber lengths of vibrissa follicles and the proliferation of dermal papilla cells. These results suggest that norgalanthamine, a principal of C. asiaticum, has the potential to promote hair growth via the proliferation of dermal papilla.
Kim
Sang-Cheol
SC
Department of Medicine, School of Medicine, Jeju National University, Jeju 690-756, Korea.
Kang
Jung-Il
JI
Kim
Min-Kyoung
MK
Hyun
Jae-Hee
JH
Boo
Hye-Jin
HJ
Park
Doek-Bae
DB
Lee
Young-Jae
YJ
Yoo
Eun-Sook
ES
Kim
Young Ho
YH
Kim
Young Heui
YH
Kang
Hee-Kyoung
HK
D047151:Amaryllidaceae Alkaloids / Q000494:pharmacology*; D000818:Animals; D002478:Cells, Cultured; D031407:Crinum; D019610:Cytoprotection / Q000187:drug effects; D005260:Female; D005702:Galantamine / Q000031:analogs & derivatives* / Q000494:pharmacology; D006197:Hair / Q000187:drug effects / Q000254:growth & development*; D018859:Hair Follicle / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008914:Minoxidil / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology*; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D014738:Vibrissae
D047151:Amaryllidaceae Alkaloids; D010936:Plant Extracts; D018809:Proliferating Cell Nuclear Antigen; D005702:Galantamine; C548174:norgalanthamine; D008914:Minoxidil