Variation in RGS2 is associated with suicidal ideation in an epidemiological study of adults exposed to the 2004 Florida hurricanes.
This study examined whether rs4606, a single nucleotide polymorphism (SNP) in the translated region at the 3' end of RGS2, was related to suicidal ideation in an epidemiologic sample of adults living in areas affected by the 2004 Florida hurricanes. An epidemiologic sample of residents of Florida was recruited via random digit-dial procedures after the 2004 Florida hurricanes; participants were interviewed about suicidal ideation, hurricane exposure, and social support. Participants who returned buccal DNA samples via mail (n = 607) were included here. Rs4606 in RGS2 was associated with increased symptoms of current suicidal ideation (p < 0.01). Each "C" allele was associated with 5.59 times increased risk of having current ideation. No gene-by-environment interactions were found, perhaps due to low power. RGS2 rs4606 is related to risk of current suicidal ideation in stressor-exposed adults.
Amstadter
Ananda B
AB
Department of Psychiatry and Behavioral Science, Medical University of South Carolina, Charleston, South Carolina 29425, USA. amstadt@musc.edu
Koenen
Karestan C
KC
Ruggiero
Kenneth J
KJ
Acierno
Ron
R
Galea
Sandro
S
Kilpatrick
Dean G
DG
Gelernter
Joel
J
D000328:Adult; D055867:Cyclonic Storms; D005260:Female; D005431:Florida; D006801:Humans; D007092:Imagination; D008016:Life Change Events; D008297:Male; D020641:Polymorphism, Single Nucleotide; D020710:RGS Proteins / Q000235:genetics*; D012307:Risk Factors; D016728:Self-Injurious Behavior / Q000235:genetics*; D013313:Stress Disorders, Post-Traumatic / Q000453:epidemiology; D013406:Suicide, Attempted / Q000523:psychology / Q000706:statistics & numerical data*; D055815:Young Adult
D020710:RGS Proteins; C087182:RGS2 protein, human