Serum prolidase activity and oxidative status in patients with stage I endometrial cancer.
BACKGROUND
We aimed to investigate the serum prolidase activity, total oxidant status (TOS), total antioxidant capacity (TAC), and total free sulfhydryl (-SH) groups in patients with stage I endometrial cancer.


METHODS
Serum prolidase activity, TOS, TAC, and -SH levels were measured in patients with endometrial cancer (n = 23) and controls (n = 25).


RESULTS
Serum prolidase activity and TOS were significantly higher in patients with endometrial cancer than in controls (P = 0.02 and P = 0.02, respectively), whereas TAC and -SH group levels were significantly lower (P = 0.004 and P = 0.001, respectively). There were no differences between surgical stages IA and IB or between stages IB and IC (P = 0.189 and P = 0.161, respectively) with respect to prolidase levels, whereas there was a significant difference between stages IA and IC (P < 0.001).


CONCLUSIONS
Increased serum prolidase activity and oxidative stress may be associated with endometrial cancer, and increased serum prolidase activity may be related to local invasion of endometrial cancer.
Arioz
Dagistan Tolga
DT
Department of Obstetrics and Gynecology, Medical School, Afyonkarahisar Kocatepe University, Afyonkarahisar, Turkey. dagistantolgaarioz@yahoo.com
Camuzcuoglu
Hakan
H
Toy
Harun
H
Kurt
Sefa
S
Celik
Hakim
H
Aksoy
Nurten
N
D000328:Adult; D000975:Antioxidants / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000097:blood / Q000378:metabolism; D018269:Carcinoma, Endometrioid / Q000097:blood* / Q000378:metabolism / Q000473:pathology*; D016022:Case-Control Studies; D004150:Dipeptidases / Q000097:blood* / Q000378:metabolism; D016889:Endometrial Neoplasms / Q000097:blood* / Q000378:metabolism / Q000473:pathology*; D005260:Female; D005609:Free Radicals / Q000097:blood / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D016877:Oxidants / Q000097:blood / Q000378:metabolism; D018384:Oxidative Stress / Q000502:physiology; D013438:Sulfhydryl Compounds / Q000097:blood / Q000378:metabolism
D000975:Antioxidants; D014408:Biomarkers, Tumor; D005609:Free Radicals; D016877:Oxidants; D013438:Sulfhydryl Compounds; D004150:Dipeptidases; C022449:proline dipeptidase