title: Pathophysiology of colonic causes of chronic constipation.
abstract: Colonic sensorimotor dysfunction is recognized as the principal pathophysiological mechanism underpinning chronic constipation. This review addresses current understanding derived from both human and animal studies, with particular reference made to methods of investigation.
authors.affiliation: Department of Medicine, University of New South Wales, St George Hospital, Sydney, Australia. p.dinning@unsw.edu.au
authors.forename: P G
authors.initials: PG
authors.lastname: Dinning
authors.forename: T K
authors.initials: TK
authors.lastname: Smith
authors.forename: S M
authors.initials: SM
authors.lastname: Scott
mesh_terms: D000818:Animals; D002908:Chronic Disease; D002940:Circadian Rhythm / Q000502:physiology; D003106:Colon / Q000000981:diagnostic imaging / Q000503:physiopathology*; D003248:Constipation / Q000000981:diagnostic imaging / Q000503:physiopathology*; D004195:Disease Models, Animal; D005769:Gastrointestinal Motility / Q000502:physiology; D005772:Gastrointestinal Transit / Q000502:physiology; D006801:Humans; D008365:Manometry; D011312:Pressure; D011859:Radiography; D011877:Radionuclide Imaging; D012018:Reflex / Q000502:physiology