title: A dual-strain feline calicivirus vaccine stimulates broader cross-neutralization antibodies than a single-strain vaccine and lessens clinical signs in vaccinated cats when challenged with a homologous feline calicivirus strain associated with virulent systemic disease.
abstract: Feline calicivirus (FCV) causes an array of clinical disease in cats. Traditionally this disease has been associated with respiratory disease, limping, or chronic stomatitis. Within the last 10 years, virulent systemic feline calicivirus (VS-FCV) has been recognized which causes additional clinical signs and has a higher fatality rate. A dual-strain FCV vaccine containing a strain of FCV associated with traditional respiratory disease and a VS-FCV strain stimulates serum cross-neutralization antibodies when tested against field strains from Europe and VS-FCV strains from USA. Following challenge with a homologous VS-FCV strain, vaccinated cats had significantly reduced clinical signs.
authors.affiliation: Fort Dodge Animal Health, 9225 Indian Creek Parkway, Suite 400, Overland Park, KS 66213, USA.
authors.forename: Chengjin
authors.initials: C
authors.lastname: Huang
authors.forename: Jennifer
authors.initials: J
authors.lastname: Hess
authors.forename: Michael
authors.initials: M
authors.lastname: Gill
authors.forename: David
authors.initials: D
authors.lastname: Hustead
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood* / Q000276:immunology; D017250:Caliciviridae Infections / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary* / Q000821:virology; D017927:Calicivirus, Feline / Q000145:classification / Q000235:genetics / Q000276:immunology*; D002371:Cat Diseases / Q000276:immunology / Q000517:prevention & control* / Q000821:virology; D002415:Cats; D005260:Female; D008297:Male; D009500:Neutralization Tests / Q000662:veterinary; D016896:Treatment Outcome; D017778:Vaccines, Combined; D014765:Viral Vaccines / Q000008:administration & dosage*
chemical_list: D000914:Antibodies, Viral; D017778:Vaccines, Combined; D014765:Viral Vaccines