Comparative in-vitro activity of cefsulodin and ceftazidime against ticarcillin-resistant Pseudomonas aeruginosa.
The in-vitro antibacterial activity of ceftazidime was compared with that of cefsulodin and ticarcillin against 140 strains of Pseudomonas aeruginosa. Against 123 clinical isolates, geometric mean MICs were 1499mg/l for ticarcillin, 15 mg/l for cefsulodin and 2.1 mg/l for ceftazidime. Against constitutive beta-lactamase producers (93 strains), and according to the type of enzyme (TEM-1, carbenicillinases, oxacillinases), ceftazidime had similar activity but MICs of cefsulodin were particularly affected by highly ticarcillin-resistant (carbenicillinase pIs 53, 5.7 and 575) strains. Against ticarcillin-resistant (constitutive beta-lactamase non-producers) and ticarcillin-susceptible strains, the MICs of ceftazidime were slightly lower than those of cefsulodin.
Philippon
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A
C.H.U. Cochin, Service de Bactériologie 75674-Paris Cedex 14, France.
Paul
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G
Nevot
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P
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002441:Cefsulodin / Q000494:pharmacology*; D002442:Ceftazidime / Q000494:pharmacology*; D003428:Cross Infection / Q000382:microbiology; D024881:Drug Resistance, Bacterial; D006801:Humans; D008826:Microbial Sensitivity Tests; D011552:Pseudomonas Infections / Q000382:microbiology; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D013982:Ticarcillin / Q000494:pharmacology*; D001618:beta-Lactamases / Q000378:metabolism
D000900:Anti-Bacterial Agents; D002442:Ceftazidime; D001618:beta-Lactamases; D013982:Ticarcillin; D002441:Cefsulodin