title: Zinc-dependent binding between peptides derived from rainbow trout CD8alpha and LCK.
abstract: The cytoplasmic tail of mammalian CD8alpha binds the kinase LCK in a zinc-dependent manner. In analogy with a previous study for humans (Kim et al., 2003) peptides were synthesized from rainbow trout CD8alpha and LCK. Surface plasmon resonance (SPR) analysis indicated that also in fish these molecules bind to each other in a zinc-dependent manner.
authors.affiliation: Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi 470-1192, Japan.
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Hayashi
authors.forename: Masami
authors.initials: M
authors.lastname: Takeuchi
authors.forename: Teruyuki
authors.initials: T
authors.lastname: Nakanishi
authors.forename: Keiichiro
authors.initials: K
authors.lastname: Hashimoto
authors.forename: Johannes Martinus
authors.initials: JM
authors.lastname: Dijkstra
mesh_terms: D000818:Animals; D001665:Binding Sites; D016827:CD8 Antigens / Q000378:metabolism*; D002645:Chickens; D006801:Humans; D019860:Lymphocyte Specific Protein Tyrosine Kinase p56(lck) / Q000378:metabolism*; D051379:Mice; D017686:Oncorhynchus mykiss / Q000276:immunology / Q000378:metabolism*; D016415:Sequence Alignment; D020349:Surface Plasmon Resonance; D015032:Zinc / Q000378:metabolism / Q000502:physiology*
chemical_list: D016827:CD8 Antigens; C431698:CD8alpha antigen; D019860:Lymphocyte Specific Protein Tyrosine Kinase p56(lck); D015032:Zinc