Dismissing links between HPV and aggressive tongue cancer in young patients.
BACKGROUND
The objective of this study is to disprove and dismiss etiological links between human papillomavirus (HPV) and aggressive tongue cancer in young patients.


METHODS
Review of available literature with focus on presenting the epidemiological, histological and immunohistochemical arguments against an association between HPV and aggressive glossal neoplasm in younger populations.


CONCLUSIONS
HPV is not associated with the recent surge in the incidence of biologically aggressive oral cavity cancer in young populations.
Salem
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Department of Surgery, Al-Bayader Hospital, 8th Circle, Amman 11814, Jordan. alwikah@hotmail.com
D000328:Adult; D006801:Humans; D015994:Incidence; D030361:Papillomavirus Infections / Q000150:complications* / Q000453:epidemiology; D014062:Tongue Neoplasms / Q000453:epidemiology / Q000821:virology*; D055815:Young Adult