The effects of osteoformin on mineralisation and quality of newly formed bone during mandibular distraction osteogenesis in rabbits.
OBJECTIVE
The aim of this experimental study was to evaluate the effects of osteoformin on mineralization and quality of newly formed bone during distraction osteogenesis in rabbits.


METHODS
Distraction rate was as 1 mm/day for 5 days. In the experimental group, 100 microg/kg osteoformin in 100 microL/kg phosphate-buffered saline (PBS) was injected into the distraction area at day 1 and day 7 after surgery. In the control group, only 100 microL/kg PBS was injected on the same days. On day 42, the animals were killed.


RESULTS
Bone mineral density and bone mineral content values increased significantly in the experimental group (P < .05). Newly formed bone areas, number of vessels and osteoblasts were significantly greater in experimental group (P < .05). The number of fibroblasts were also greater, but it was not significant statistically (P > .05). The number of osteoclasts was significantly lower in experimental group (P < .05).


CONCLUSIONS
The results of this study show that osteoformin improves healing of regenerate in distraction osteogenesis in rabbits.
Pampu
A Alper
AA
Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Karadeniz Technical University, Trabzon, Turkey. alperpampu@hotmail.com
Ozkaynak
Ozkan
O
Senel
Figen Cizmeci
FC
Cankaya
Mustafa
M
Dolanmaz
Doğan
D
Ersöz
Safak
S
Avunduk
Mustafa Cihat
MC
D000818:Animals; D015519:Bone Density / Q000187:drug effects / Q000502:physiology; D001861:Bone Regeneration / Q000187:drug effects / Q000502:physiology*; D002113:Calcification, Physiologic / Q000187:drug effects / Q000502:physiology*; D008297:Male; D008334:Mandible / Q000187:drug effects / Q000601:surgery*; D019186:Mandibular Advancement / Q000379:methods; D010012:Osteogenesis / Q000187:drug effects / Q000502:physiology*; D019857:Osteogenesis, Distraction / Q000379:methods*; D010455:Peptides / Q000008:administration & dosage / Q000502:physiology*; D011108:Polymers / Q000008:administration & dosage; D011817:Rabbits; D011897:Random Allocation
D010455:Peptides; D011108:Polymers; C017645:polyaspartate