The role of neurotrophins in the regulation of myelin development.
Neurotrophins comprise a family of growth factors that are expressed in a variety of cell types, and which exert influences on a large range of cellular activities that are important for development and the maintenance of the nervous system, as well as in neurodegenerative and psychiatric disorders. More recently, neurotrophins have been implicated in influencing the dynamic and complex signals that occur between neurons and glial cells, including Schwann cells in the peripheral nervous system and oligodendrocytes in the central nervous system that regulate myelination. Here we review the recent studies that identify neurotrophins as important regulators of both peripheral and central myelination, highlight some of the many questions that remain to be answered, and identify possibilities for further research.
Xiao
Junhua
J
Neurotrophin Signaling Laboratory, Centre for Neuroscience, The University of Melbourne, Melbourne, Vic., Australia. xiaoj@unimelb.edu.au
Kilpatrick
Trevor J
TJ
Murray
Simon S
SS
D000818:Animals; D009186:Myelin Sheath / Q000502:physiology*; D009414:Nerve Growth Factors / Q000378:metabolism*; D009474:Neurons / Q000502:physiology; D017475:Receptors, Nerve Growth Factor / Q000378:metabolism; D012583:Schwann Cells / Q000502:physiology
D009414:Nerve Growth Factors; D017475:Receptors, Nerve Growth Factor