title: SDF1-3' a gene polymorphism is associated with laryngeal cancer.
abstract: The SDF1-3' G801A (rs 1801157) polymorphism is associated with increased risk of various types of cancers, including those of the neck and head. Using PCR-RFLPs, we investigated the distribution of SDF1-3' G801A genotypes in patients with laryngeal cancer (n = 118) and controls (n = 250) in Poland. We found that patients with SDF1-3' A/A and G/A genotypes exhibit a 1.863-fold increased risk of laryngeal cancer (95% CI = 1.177-2.949, p = 0.0086). However, there was no significant increase in risk for the homozygous SDF1-3' A/A genotype OR = 3.235 (95% CI = 0.5330-19.633, p = 0.3329). We also did not observe a significant association between tumor characteristics and prevalence of alleles or genotypes for the SDF1-3' G801A polymorphism. Our findings suggest that the SDF1-3'A variant may be associated with an increased risk of laryngeal cancer.
authors.affiliation: Department of Biochemistry and Molecular Biology, Poznań University of Medical Sciences, 6 Swiecickiego St., 60-781, Poznań, Poland.
authors.forename: Lukasz
authors.initials: L
authors.lastname: Kruszyna
authors.forename: Margarita
authors.initials: M
authors.lastname: Lianeri
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Rydzanicz
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Szyfter
authors.forename: Paweł P
authors.initials: PP
authors.lastname: Jagodziński
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D054377:Chemokine CXCL12 / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007822:Laryngeal Neoplasms / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D012307:Risk Factors
chemical_list: D054377:Chemokine CXCL12