title: Anthropometric measures and epithelial ovarian cancer risk in the European Prospective Investigation into Cancer and Nutrition.
abstract: We examined the associations of measured anthropometric factors, including general and central adiposity and height, with ovarian cancer risk. We also investigated these associations by menopausal status and for specific histological subtypes. Among 226,798 women in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, there were 611 incident cases of primary, malignant, epithelial ovarian cancer diagnosed during a mean 8.9 years of follow-up. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs), adjusted for potential confounders. Compared to women with body mass index (BMI) < 25 kg/m2, obesity (BMI > or = 30 kg/m2) was associated with excess ovarian cancer risk for all women combined (HR = 1.33, 95% CI = 1.05-1.68; p(trend) = 0.02) and postmenopausal women (HR = 1.59, 95% CI = 1.20-2.10; p(trend) = 0.001), but the association was weaker for premenopausal women (HR = 1.16, 95% CI = 0.65-2.06; p(trend) = 0.65). Neither height or weight gain, nor BMI-adjusted measures of fat distribution assessed by waist circumference, waist-hip ratio (WHR) or hip circumference were associated with overall risk. WHR was related to increased risk of mucinous tumors (BMI-adjusted HR per 0.05 unit increment = 1.17, 95% CI = 1.00-1.38). For all women combined, no other significant associations with risk were observed for specific histological subtypes. This large, prospective study provides evidence that obesity is an important modifiable risk factor for epithelial ovarian cancer, particularly among postmenopausal women.
authors.affiliation: Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany.
authors.forename: Petra H
authors.initials: PH
authors.lastname: Lahmann
authors.forename: Anne E
authors.initials: AE
authors.lastname: Cust
authors.forename: Christine M
authors.initials: CM
authors.lastname: Friedenreich
authors.forename: Mandy
authors.initials: M
authors.lastname: Schulz
authors.forename: Annekatrin
authors.initials: A
authors.lastname: Lukanova
authors.forename: Rudolf
authors.initials: R
authors.lastname: Kaaks
authors.forename: Eva
authors.initials: E
authors.lastname: Lundin
authors.forename: Anne
authors.initials: A
authors.lastname: Tjønneland
authors.forename: Jytte
authors.initials: J
authors.lastname: Halkjaer
authors.forename: Marianne Tang
authors.initials: MT
authors.lastname: Severinsen
authors.forename: Kim
authors.initials: K
authors.lastname: Overvad
authors.forename: Agnès
authors.initials: A
authors.lastname: Fournier
authors.forename: Nathalie
authors.initials: N
authors.lastname: Chabbert-Buffet
authors.forename: Françoise
authors.initials: F
authors.lastname: Clavel-Chapelon
authors.forename: Laure
authors.initials: L
authors.lastname: Dossus
authors.forename: Tobias
authors.initials: T
authors.lastname: Pischon
authors.forename: Heiner
authors.initials: H
authors.lastname: Boeing
authors.forename: Antonia
authors.initials: A
authors.lastname: Trichopoulou
authors.forename: Pagona
authors.initials: P
authors.lastname: Lagiou
authors.forename: Androniki
authors.initials: A
authors.lastname: Naska
authors.forename: Domenico
authors.initials: D
authors.lastname: Palli
authors.forename: Sara
authors.initials: S
authors.lastname: Grioni
authors.forename: Amalia
authors.initials: A
authors.lastname: Mattiello
authors.forename: Rosario
authors.initials: R
authors.lastname: Tumino
authors.forename: Carlotta
authors.initials: C
authors.lastname: Sacerdote
authors.forename: María-Luisa
authors.initials: ML
authors.lastname: Redondo
authors.forename: Paula
authors.initials: P
authors.lastname: Jakszyn
authors.forename: María-José
authors.initials: MJ
authors.lastname: Sánchez
authors.forename: María-José
authors.initials: MJ
authors.lastname: Tormo
authors.forename: Eva
authors.initials: E
authors.lastname: Ardanaz
authors.forename: Larraitz
authors.initials: L
authors.lastname: Arriola
authors.forename: Jonas
authors.initials: J
authors.lastname: Manjer
authors.forename: Karin
authors.initials: K
authors.lastname: Jirström
authors.forename: H Bas
authors.initials: HB
authors.lastname: Bueno-de-Mesquita
authors.forename: Anne M
authors.initials: AM
authors.lastname: May
authors.forename: Petra H M
authors.initials: PH
authors.lastname: Peeters
authors.forename: N Charlotte
authors.initials: NC
authors.lastname: Onland-Moret
authors.forename: Sheila
authors.initials: S
authors.lastname: Bingham
authors.forename: Kay-Tee
authors.initials: KT
authors.lastname: Khaw
authors.forename: Naomi E
authors.initials: NE
authors.lastname: Allen
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Spencer
authors.forename: Sabina
authors.initials: S
authors.lastname: Rinaldi
authors.forename: Nadia
authors.initials: N
authors.lastname: Slimani
authors.forename: Véronique
authors.initials: V
authors.lastname: Chajes
authors.forename: Dominique
authors.initials: D
authors.lastname: Michaud
authors.forename: Teresa
authors.initials: T
authors.lastname: Norat
authors.forename: Elio
authors.initials: E
authors.lastname: Riboli
mesh_terms: D000328:Adult; D000368:Aged; D000886:Anthropometry; D015992:Body Mass Index; D002277:Carcinoma / Q000453:epidemiology* / Q000209:etiology*; D005060:Europe / Q000453:epidemiology; D005260:Female; D006801:Humans; D016014:Linear Models; D008593:Menopause; D008875:Middle Aged; D015999:Multivariate Analysis; D009752:Nutritional Status; D009765:Obesity / Q000150:complications*; D056128:Obesity, Abdominal / Q000150:complications; D016017:Odds Ratio; D010051:Ovarian Neoplasms / Q000453:epidemiology* / Q000209:etiology*; D016016:Proportional Hazards Models; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D055105:Waist Circumference; D049629:Waist-Hip Ratio