title: Early response to family-based treatment for adolescent anorexia nervosa.
abstract: OBJECTIVE
  The purpose of this study was to determine if early weight gain predicted remission at the end of treatment in a clinic sample of adolescents with anorexia nervosa (AN).
  
  
  METHODS
  Sixty five adolescents with AN (mean age = 14.9 years, SD = 2.1), from two sites (Chicago n = 45; Columbia n = 20) received a course of manualized family-based treatment (FBT). Response to treatment was assessed using percent ideal body weight (IBW) with remission defined as having achieved ≥ 95% IBW at end of treatment (Session 20).
  
  
  RESULTS
  Receiver operating characteristic analyses showed that a gain of at least 2.88% in ideal body weight by Session 4 best predicted remission at end of treatment (AUC = 0.674; p = 0.024).
  
  
  CONCLUSIONS
  Results suggest that adolescents with AN, receiving FBT, who do not show early weight gain are unlikely to remit at end of treatment.
authors.affiliation: Department of Psychiatry and Behavioral Neuroscience, The University of Chicago, Chicago, Illinois 60637, USA. pdoyle@yoda.bsd.uchicago.edu
authors.forename: Peter M
authors.initials: PM
authors.lastname: Doyle
authors.forename: Daniel
authors.initials: D
authors.lastname: Le Grange
authors.forename: Katharine
authors.initials: K
authors.lastname: Loeb
authors.forename: Angela Celio
authors.initials: AC
authors.lastname: Doyle
authors.forename: Ross D
authors.initials: RD
authors.lastname: Crosby
mesh_terms: D000293:Adolescent; D000856:Anorexia Nervosa / Q000175:diagnosis / Q000523:psychology* / Q000628:therapy*; D001835:Body Weight; D002641:Chicago; D005196:Family Therapy / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D009518:New York; D012372:ROC Curve; D013997:Time Factors; D016896:Treatment Outcome; D015430:Weight Gain / Q000502:physiology*