[Advancement of researches on relationship between hepatitis B virus and severe hepatitis B].
Approximately 1% of patients infected with hepatitis B virus (HBV) develops severe hepatitis B, which is characterized by rapid destruction of liver parenchyma. The case fatality rates of HBV-induced severe hepatitis B in China range between 60% and 80%. In other words, more than half of the patients with severe hepatitis B ultimately require liver transplantation or die of liver failure. The pathogenesis of severe hepatitis B is not well understood. Previous studies have indicated that complicated interaction between viral factors and host immune response may be involved. This article tries to review the advancement of researches on the relationship between HBV and severe hepatitis B.
Sun
Hui
H
The Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu 610041, China.
Tang
Hong
H
D006508:Hepatitis Antibodies / Q000097:blood; D006509:Hepatitis B / Q000276:immunology* / Q000821:virology*; D006515:Hepatitis B virus / Q000235:genetics* / Q000472:pathogenicity; D054884:Host-Pathogen Interactions / Q000235:genetics*; D006801:Humans; D009154:Mutation; D012720:Severity of Illness Index
D006508:Hepatitis Antibodies