The complex field of interplay between vasoactive agents.
Lai et al. provide important new information regarding the interaction between the sympathetic and renin-angiotensin systems in the regulation of glomerular afferent arteriolar contractility. Their study demonstrates a calcium-independent enhanced contractile response to angiotensin II following norepinephrine administration. The interplay between the norepinephrine- and angiotensin II-stimulated pathways could potentially be important in physiological as well as pathophysiological situations with increased sympathetic nervous system activity, such as hypertension.
Hansen
Pernille B
PB
Department of Physiology and Pharmacology, Institute of Medical Biology, University of Southern Denmark, Odense, Denmark. pbhansen@health.sdu.dk
D058668:Adrenergic alpha-1 Receptor Antagonists; D058669:Adrenergic alpha-2 Receptor Antagonists; D000804:Angiotensin II / Q000378:metabolism*; D000818:Animals; D001160:Arterioles / Q000378:metabolism; D020013:Calcium Signaling / Q000187:drug effects; D002318:Cardiovascular Diseases / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D007668:Kidney / Q000098:blood supply*; D051379:Mice; D018994:Myosin Light Chains / Q000378:metabolism; D043263:Myosin-Light-Chain Phosphatase / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism*; D010766:Phosphorylation; D018340:Receptors, Adrenergic, alpha-1 / Q000378:metabolism; D018341:Receptors, Adrenergic, alpha-2 / Q000378:metabolism; D012079:Renal Circulation / Q000187:drug effects; D014661:Vasoconstriction / Q000187:drug effects; D048051:p38 Mitogen-Activated Protein Kinases / Q000378:metabolism
D058668:Adrenergic alpha-1 Receptor Antagonists; D058669:Adrenergic alpha-2 Receptor Antagonists; D018994:Myosin Light Chains; D018340:Receptors, Adrenergic, alpha-1; D018341:Receptors, Adrenergic, alpha-2; D000804:Angiotensin II; D048051:p38 Mitogen-Activated Protein Kinases; D043263:Myosin-Light-Chain Phosphatase; D009638:Norepinephrine