Genotypes, superantigen gene profiles, and presence of exfoliative toxin genes in clinical methicillin-susceptible Staphylococcus aureus isolates.
We compared genotype and virulence gene profiles for strains from carriers with autologous invasive infection (n = 56), nasal isolates from matched carriers (n = 108), and invasive strains from noncarriers (n = 34). Superantigen gene profiles and presence of exfoliative toxin genes A and D were associated with clonal complex rather than with invasive disease.
van Trijp
Marijke J C A
MJ
Maasstad Hospital, HT Rotterdam, The Netherlands. m.vantrijp@erasmusmc.nl
Melles
Damian C
DC
Snijders
Susan V
SV
Wertheim
Heiman F L
HF
Verbrugh
Henri A
HA
van Belkum
Alex
A
van Wamel
Willem J
WJ
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000942:Antigens, Bacterial / Q000235:genetics*; D001426:Bacterial Proteins / Q000235:genetics; D002353:Carrier State / Q000382:microbiology; D016172:DNA Fingerprinting; D004269:DNA, Bacterial / Q000235:genetics; D005083:Exfoliatins / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D013203:Staphylococcal Infections / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000235:genetics* / Q000302:isolation & purification; D018089:Superantigens / Q000235:genetics*; D037521:Virulence Factors / Q000235:genetics
D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D004269:DNA, Bacterial; D005083:Exfoliatins; D018089:Superantigens; D037521:Virulence Factors