Shifting in balance between osteogenesis and adipogenesis substantially influences hematopoiesis.
Adipocytes have been viewed as a space-filler in bone marrow for a long time. However, a recent study (Naveiras et al., 2009. Nature 460, 259-263) shows that adipocytes are microenvironmental components that suppress hematopoiesis under homeostatic and especially stressed conditions.
Sugimura
Ryohichi
R
Stowers Institute for Medical Research, Kansas City, MO 64110, USA.
Li
Linheng
L
D017667:Adipocytes / Q000166:cytology / Q000378:metabolism; D050156:Adipogenesis / Q000502:physiology*; D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology / Q000378:metabolism; D006410:Hematopoiesis / Q000502:physiology*; D006412:Hematopoietic Stem Cells; D006801:Humans; D051379:Mice; D008954:Models, Biological; D010012:Osteogenesis / Q000502:physiology*