title: Synthesis of oligo(ethylene glycol) substituted phosphatidylcholines: secretory PLA2-targeted precursors of NSAID prodrugs.
abstract: A series of new phosphatidylcholine analogues with structurally modified sn-2-substituents have been prepared. The synthetic compounds include oligo(ethylene glycol) derivatives with chain-terminal pharmacophores that upon catalytic hydrolysis by phospholipase A(2) yielded a series of oligo(ethylene glycol)-conjugates of the respective drugs. The approach here outlined may open a new way to employ OEG derivatives of phospholipids for therapeutic applications as secretory PLA(2)-targeted precursors of prodrugs.
authors.affiliation: Department of Chemistry and Biochemistry, California State University, 18111 Nordhoff Street, Northridge, CA 91330-8262, USA.
authors.forename: Renato
authors.initials: R
authors.lastname: Rosseto
authors.forename: Joseph
authors.initials: J
authors.lastname: Hajdu
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000737:chemistry; D006868:Hydrolysis; D010713:Phosphatidylcholines / Q000138:chemical synthesis* / Q000737:chemistry; D054497:Phospholipases A2, Secretory / Q000378:metabolism*; D011355:Prodrugs / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D010713:Phosphatidylcholines; D011355:Prodrugs; D054497:Phospholipases A2, Secretory