title: An evaluation of calcium hydroxylapatite (Radiesse) for cosmetic nasolabial fold correction: a meta-analysis and patient centric outcomes study.
abstract: The use of calcium hydroxylapatite (Radiesse, BioForm Medical, San Mateo, California) for cosmetic soft tissue augmentation has increased significantly in recent years. Only a handful of authors have reported patient satisfaction data. A meta-analysis of published data was performed using a 5-point scale for patient satisfaction to allow data comparison across studies. A patient-centric outcomes study was also performed at our institution, using a blinded questionnaire. Five usable studies were identified for meta-analysis. Patient satisfaction was 4.16 of 5 in 324 patients at 3 to 6 months and 4.15 in 86 patients at 1 year. In our institutional patient-centric outcomes study, the early satisfaction rate was 3.7 of 5. At 1 year the rate was only 2.3 of 5. Calcium hydroxylapatite remains a viable option for augmentation of facial soft tissue structures. However, this report shows that further, accurate, large population outcomes assessments are absolutely required.
authors.affiliation: Department of Surgery, Mayo Clinic, Jacksonville, FL 32224, USA.
authors.forename: G Peter
authors.initials: GP
authors.lastname: Fakhre
authors.forename: Galen
authors.initials: G
authors.lastname: Perdikis
authors.forename: Kyle K
authors.initials: KK
authors.lastname: Shaddix
authors.forename: Sarvam P
authors.initials: SP
authors.lastname: Terkonda
authors.forename: James C
authors.initials: JC
authors.lastname: Waldorf
mesh_terms: D001672:Biocompatible Materials / Q000627:therapeutic use*; D003357:Cosmetic Techniques; D017886:Durapatite / Q000627:therapeutic use*; D005145:Face / Q000601:surgery; D006801:Humans; D009666:Nose / Q000601:surgery; D017060:Patient Satisfaction; D015595:Skin Aging / Q000187:drug effects*; D016896:Treatment Outcome
chemical_list: D001672:Biocompatible Materials; D017886:Durapatite