title: Comparison of left ventricular ejection fraction and left ventricular global strain as determinants of infarct size in patients with acute myocardial infarction.
abstract: BACKGROUND
  The aim was to compare left ventricular ejection fraction (LVEF) and left ventricular (LV) global strain by speckle tracking as predictors of final infarct size.
  
  
  METHODS
  LV global strain and LVEF by echocardiography were assessed in the acute phase and after revascularization in 39 patients with ST-elevation myocardial infarction treated with thrombolysis.
  
  
  RESULTS
  After revascularization, global strain and LVEF correlated well with infarct size measured by contrast-enhanced cardiac magnetic resonance. A cutoff value of -15.0% for global strain had a sensitivity of 90% and a specificity of 86% to identify myocardial infarcts larger than 20%. Interobserver variability, expressed by intraclass correlation coefficients, for global strain and LVEF was 0.91 and 0.72, respectively.
  
  
  CONCLUSIONS
  LV global strain is a more precise diagnostic predictor of large infarcts compared with LVEF and is more reproducible. Global strain measured after revascularization demonstrates advantages over LVEF in the evaluation of LV injury in patients with ST-elevation myocardial infarction.
authors.affiliation: Department of Medicine, Sørlandet Hospital HF, Arendal, Norway.
authors.forename: Benthe
authors.initials: B
authors.lastname: Sjøli
authors.forename: Stein
authors.initials: S
authors.lastname: Ørn
authors.forename: Bjørnar
authors.initials: B
authors.lastname: Grenne
authors.forename: Trond
authors.initials: T
authors.lastname: Vartdal
authors.forename: Otto A
authors.initials: OA
authors.lastname: Smiseth
authors.forename: Thor
authors.initials: T
authors.lastname: Edvardsen
authors.forename: Harald
authors.initials: H
authors.lastname: Brunvand
mesh_terms: D000704:Analysis of Variance; D003287:Contrast Media; D005260:Female; D006801:Humans; D016014:Linear Models; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D012372:ROC Curve; D015203:Reproducibility of Results; D012307:Risk Factors; D012680:Sensitivity and Specificity; D013318:Stroke Volume; D014463:Ultrasonography; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology
chemical_list: D003287:Contrast Media