Structural biology of the chaperone-usher pathway of pilus biogenesis.
The chaperone-usher (CU) pathway of pilus biogenesis is the most widespread of the five pathways that assemble adhesive pili at the surface of Gram-negative bacteria. Recent progress in the study of the structural biology of the CU pathway has unravelled the molecular basis of chaperone function and elucidated the mechanisms of fibre assembly at the outer membrane, leading to a comprehensive description of each step in the biogenesis pathway. Other studies have provided the molecular basis of host recognition by CU pili. The knowledge that has been gathered about both the assembly of and host recognition by CU pili has been harnessed to design promising antibiotic compounds.
Waksman
Gabriel
G
Institute of Structural and Molecular Biology, University College London and Birkbeck College, Malet Street, London, UK. g.waksman@ucl.ac.uk
Hultgren
Scott J
SJ
D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D036781:Fimbriae Proteins / Q000235:genetics / Q000378:metabolism; D010861:Fimbriae, Bacterial / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D015964:Gene Expression Regulation, Bacterial; D006090:Gram-Negative Bacteria / Q000235:genetics / Q000378:metabolism / Q000472:pathogenicity; D016905:Gram-Negative Bacterial Infections / Q000382:microbiology; D054884:Host-Pathogen Interactions; D006801:Humans; D008958:Models, Molecular; D018832:Molecular Chaperones / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D008969:Molecular Sequence Data; D013329:Structure-Activity Relationship
D001426:Bacterial Proteins; D018832:Molecular Chaperones; D036781:Fimbriae Proteins