title: Effects of gestational diabetes on fetal oxygen and glucose levels in vivo.
abstract: OBJECTIVE
  Fetal hypoxia and acidemia have been reported in pregestational diabetic pregnancies in relation to poor glycaemic control, but it is still uncertain whether this is the case in apparently well-controlled gestational diabetes.
  
  
  METHODS
  Maternal arterial and umbilical venous and arterial blood samples were collected from 37 normal (N) and 38 pregnancies complicated by gestational diabetes (GDM) at the time of caesarean section.
  
  
  METHODS
  Respiratory gases, acid-base balance, lactate and glucose concentrations were measured.
  
  
  RESULTS
  Both fetal and placental weights were significantly increased in GDM compared to N pregnancies, despite similar gestational age. Maternal biochemical parameters were similar in N and GDM but GDM fetuses were significantly more hypoxic (O2 saturation: N 63.2+/-13.9; GDM 53.8+/-14.6%, P<0.01; O2 content: N 5.5+/-1.4; GDM 4.8+/-1.2 mmol/l, P<0.05). Glucose (N 3.4+/-0.5, GDM 3.9+/-1.2 mmol/l, P<0.05) and lactate (N 1.32+/-0.49; GDM 1.64+/-0.75 mmol/l, P<0.05) concentrations were significantly increased in the umbilical vein in GDM compared to N fetuses. Placental histology was consistent with altered villous morphology.
  
  
  CONCLUSIONS
  Our data indicate that fetuses from gestational diabetic mothers have increased umbilical glucose concentrations despite normal maternal glucose levels and a reduction in oxygen saturation and O2 content together with increased lactate concentration, reflecting altered fetal metabolism. These data suggest that 'good maternal metabolic control' achieved by currently used methods of monitoring glucose control is not sufficient to ensure a normal oxygenation status and metabolic milieu for the fetus in GDM pregnancies.
authors.affiliation: Department of Clinical Sciences L.Sacco, University of Milan, Milan, Italy. emanuelataricco@libero.it
authors.forename: E
authors.initials: E
authors.lastname: Taricco
authors.forename: T
authors.initials: T
authors.lastname: Radaelli
authors.forename: G
authors.initials: G
authors.lastname: Rossi
authors.forename: M S
authors.initials: MS
authors.lastname: Nobile de Santis
authors.forename: G P
authors.initials: GP
authors.lastname: Bulfamante
authors.forename: L
authors.initials: L
authors.lastname: Avagliano
authors.forename: I
authors.initials: I
authors.lastname: Cetin
mesh_terms: D000136:Acid-Base Equilibrium / Q000502:physiology; D000328:Adult; D001724:Birth Weight / Q000502:physiology; D001786:Blood Glucose / Q000032:analysis*; D001835:Body Weight / Q000502:physiology; D002245:Carbon Dioxide / Q000097:blood; D002585:Cesarean Section; D016640:Diabetes, Gestational / Q000097:blood* / Q000473:pathology / Q000503:physiopathology; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D009929:Organ Size / Q000502:physiology; D010100:Oxygen / Q000097:blood*; D010920:Placenta / Q000473:pathology; D011247:Pregnancy; D015430:Weight Gain / Q000502:physiology
chemical_list: D001786:Blood Glucose; D002245:Carbon Dioxide; D010100:Oxygen