title: High lung allocation score is associated with increased morbidity and mortality following transplantation.
abstract: BACKGROUND
  The lung allocation score (LAS) was initiated in May 2005 to allocate lungs based on medical urgency and posttransplant survival. The purpose of this study was to determine if there is an association between an elevated LAS at the time of transplantation and increased postoperative morbidity and mortality.
  
  
  METHODS
  The United Network for Organ Sharing provided de-identified patient-level data. Analysis included lung transplant recipients aged >or= 12 years who received transplants between April 5, 2006, and December 31, 2007 (n = 3,836). Recipients were stratified into three groups: LAS < 50 (n = 3,161, 83.87%), LAS 50 to 75 (n = 411, 10.9%), and LAS >or= 75 (n = 197, 5.23%), referred to as low LAS (LLAS), intermediate LAS (ILAS), and high LAS (HLAS), respectively. The primary outcome was posttransplant graft survival at 1 year. Secondary outcomes included length of stay and in-hospital complications.
  
  
  RESULTS
  HLAS recipients had significantly worse actuarial survival at 90 days and 1 year compared with LLAS recipients. When transplant recipients were stratified by disease etiology, a trend of decreased survival with elevated LAS was observed across all major causes of lung transplant. HLAS recipients were more likely to require dialysis or to have infections compared with LLAS recipients (P < .001). In addition, length of stay was higher in the HLAS group when compared with the LLAS group (P < .001).
  
  
  CONCLUSIONS
  HLAS is associated with decreased survival and increased complications during the transplant hospitalization. Whereas the LAS has improved organ allocation through decreased waiting list deaths and waiting list times, lower survival and higher morbidity among HLAS recipients suggests that continued review of LAS scoring is needed to ensure optimal long-term transplant survival.
authors.affiliation: Division of Cardiothoracic Surgery, Department of Surgery, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Russo
authors.forename: Alexander
authors.initials: A
authors.lastname: Iribarne
authors.forename: Kimberly N
authors.initials: KN
authors.lastname: Hong
authors.forename: Ryan R
authors.initials: RR
authors.lastname: Davies
authors.forename: Steve
authors.initials: S
authors.lastname: Xydas
authors.forename: Hiroo
authors.initials: H
authors.lastname: Takayama
authors.forename: Ali
authors.initials: A
authors.lastname: Ibrahimiye
authors.forename: Annetine C
authors.initials: AC
authors.lastname: Gelijns
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Bacchetta
authors.forename: Frank
authors.initials: F
authors.lastname: D'Ovidio
authors.forename: Selim
authors.initials: S
authors.lastname: Arcasoy
authors.forename: Joshua R
authors.initials: JR
authors.lastname: Sonett
mesh_terms: D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D015276:Health Care Rationing; D006801:Humans; D008171:Lung Diseases / Q000401:mortality / Q000601:surgery*; D016040:Lung Transplantation / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D009017:Morbidity / Q000639:trends; D018579:Patient Selection; D011183:Postoperative Complications / Q000453:epidemiology*; D012189:Retrospective Studies; D012720:Severity of Illness Index; D015996:Survival Rate / Q000639:trends; D014019:Tissue Donors / Q000706:statistics & numerical data*; D014481:United States / Q000453:epidemiology; D014850:Waiting Lists