Clinical implications of molecular markers in follicular cell-derived thyroid cancer.
The increasing use/applications of molecular biology techniques have provided new insights on the genetic changes that underlie carcinogenesis and tumor progression in thyroid cancer. Molecular analysis may improve the histopathologic evaluation of follicular cell-derived thyroid carcinoma, not only elucidating some unresolved problems related to the diagnosis and disease prognosis, but also by improving patient management. Besides increasing our comprehension of cancer biology, either genetic alterations or gene expression profiles implicated in thyroid carcinogenesis shed new light on innovative diagnostic procedures as well as on targeted therapies.
Pinto
António E
AE
Serviço de Anatomia Patológica, Instituto Português de Oncologia de Lisboa, EPE, Rua Professor Lima Basto, 1099-023 Lisbon, Portugal. aepinto@ipolisboa.min-saude.pt
Leite
Valeriano
V
Soares
Jorge
J
D002869:Chromosome Aberrations; D006801:Humans; D013964:Thyroid Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology / Q000628:therapy