title: Generation and use of a mouse Kupffer cell line.
abstract: Kupfer cells are the most abundant population of tissue macrophages, involved in the pathogenesis of various liver diseases. We generated a murine Kupffer cell line from H2Kb-tsA58 transgenic mice, which has proved useful for the study of drug delivery, of phagocytosis of pathogens and apoptotic cells and of the role of KC in transplantation.
authors.affiliation: Division Infectious Diseases, Department of Research, University Hospital Basel, Basel, Switzerland. regine.landmann@unibas.ch
authors.forename: Regine
authors.initials: R
authors.lastname: Landmann-Suter
mesh_terms: D000826:Animal Testing Alternatives / Q000379:methods; D000818:Animals; D018929:Cell Culture Techniques / Q000379:methods; D002460:Cell Line; D006183:H-2 Antigens / Q000235:genetics; D006801:Humans; D007728:Kupffer Cells / Q000166:cytology* / Q000473:pathology / Q000821:virology; D051379:Mice; D008822:Mice, Transgenic; D013539:Simian virus 40 / Q000235:genetics
chemical_list: D006183:H-2 Antigens; C032876:H-2Kb protein, mouse