title: The OFF-pathway dominance of P2X(2)-purinoceptors is formed without visual experience.
abstract: Visual input in the critical period is an important determinant of the functions of the visual system, affecting for example the formation of the ocular dominance column in the visual cortex. The final map of columnar organization is usually determined by plastic changes in the critical period, but organization is distorted without adequate visual input. Here, we examined whether formation of the OFF-pathway dominance of P2X(2)-purinoceptor signaling in the mouse retina is the result of visual experience. The P2X(2)-purinoceptor signaling pathway developed during the critical period. However, visual experience in this period produced no plastic change in the formation of the OFF-pathway dominance of P2X(2)-purinoceptor signaling. Our findings suggest that the OFF-pathway dominance of P2X(2)-signaling in the mouse retina is intrinsically programmed.
authors.affiliation: Department of Physiology, Keio University School of Medicine, Tokyo 160-8582, Japan. mkaneda@a5.keio.jp
authors.forename: Makoto
authors.initials: M
authors.lastname: Kaneda
authors.forename: Koichi
authors.initials: K
authors.lastname: Ito
authors.forename: Yasuhide
authors.initials: Y
authors.lastname: Shigematsu
authors.forename: Yukio
authors.initials: Y
authors.lastname: Shimoda
mesh_terms: D000255:Adenosine Triphosphate / Q000494:pharmacology; D025042:Amacrine Cells / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D044385:GTP-Binding Protein alpha Subunits / Q000172:deficiency; D066298:In Vitro Techniques; D008565:Membrane Proteins / Q000172:deficiency; D051379:Mice; D008810:Mice, Inbred C57BL; D008813:Mice, Inbred ICR; D008822:Mice, Transgenic; D009433:Neural Inhibition / Q000187:drug effects / Q000502:physiology*; D018048:Receptors, Purinergic P2 / Q000235:genetics / Q000378:metabolism*; D058476:Receptors, Purinergic P2X2; D012160:Retina / Q000166:cytology*; D017299:Rod Opsins / Q000172:deficiency; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology*; D015293:Transducin / Q000172:deficiency; D014793:Visual Cortex / Q000502:physiology*; D014795:Visual Pathways / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology; D000099210:Melanopsin
chemical_list: D000255:Adenosine Triphosphate; D002795:Choline O-Acetyltransferase; D044385:GTP-Binding Protein alpha Subunits; D008565:Membrane Proteins; D018048:Receptors, Purinergic P2; D058476:Receptors, Purinergic P2X2; D017299:Rod Opsins; D015293:Transducin; D005680:gamma-Aminobutyric Acid; D000099210:Melanopsin; C489227:Cgn protein, mouse; C488949:Gnat1 protein, mouse; C546402:P2rx2 protein, mouse