[Preparation of the oral self-microemulsifying drug delivery system of GBE50].
To prepare the oral self-microemulsifying drug delivery system (SMEDDS) of GBE50, balance solubility method was used to screen emulsifier and assistant emulsifier; a pseudo-tamary phase diagram was used to prepare microemulsion; and orthogonal design was used to optimize formulation. Self-microemulsifying efficiency, dissolution, stability and pharmacokinetics of the preparation were studied. As a result, GBE50-SMEDDS of IPM, Cremophor EL, 1,2-propanediol and GBE50 could be self emulsified to form stable microemulsion with particle diameter between 20 and 50 nm when emulsifying with water. Its self-microemulsifying efficiency and dissolution are quick with good stability and it has a higher bioavailability than market existing agents Xingling particles. GBE50-SMEDDS is stable and effective.
Xiong
Ying
Y
Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Liu
Qi-De
QD
Lai
Le
L
Chen
Jian-Hai
JH
D001682:Biological Availability; D016503:Drug Delivery Systems / Q000379:methods*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D046934:Ginkgolides / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D013678:Technology, Pharmaceutical / Q000379:methods
D004365:Drugs, Chinese Herbal; D046934:Ginkgolides