title: Lung adenocarcinomas with micropapillary components.
abstract: OBJECTIVE
  Micropapillary adenocarcinoma is becoming increasingly recognized as a prognostically important histological subtype of carcinoma in various organs. This report presents the clinicopathological findings of lung adenocarcinomas with micropapillary components.
  
  
  METHODS
  A total of 15 patients with micropapillary components were selected between April 2005 and December 2008. The results of their clinical presentation, metastasis to lymph nodes, pleural invasion, pathological stage, and clinical outcomes were evaluated.
  
  
  RESULTS
  In all, 12 patients underwent a lobectomy or bilobectomy with a regional lymph node dissection; 8 showed metastases to the regional lymph nodes at the time of the operation. Altogether, 14 of 15 cases showed lymphovascular invasion; 10 cases were up-staged after the operation because of lymph node metastases or pleural invasion. The duration of follow-up ranged from 1 to 42 months (median 16 months). Seven patients are alive without disease, whereas seven are alive with disease and one patient died of disease.
  
  
  CONCLUSIONS
  These results suggest that the micropapillary components are a manifestation of aggressive behavior, as shown by the frequent lymph node metastases and pleural invasion. Surgeons should search more carefully for metastases and conduct a closer follow-up on these patients when this feature is present with lung adenocarcinoma.
authors.affiliation: Division of Thoracic Surgery, Matsue Red Cross Hospital, Matsue, Shimane, Japan. ryomaedamatsue@yahoo.co.jp
authors.forename: Ryo
authors.initials: R
authors.lastname: Maeda
authors.forename: Noritaka
authors.initials: N
authors.lastname: Isowa
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Onuma
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Miura
authors.forename: Tomoya
authors.initials: T
authors.lastname: Harada
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Touge
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Tokuyasu
authors.forename: Yuji
authors.initials: Y
authors.lastname: Kawasaki
mesh_terms: D000231:Adenocarcinoma, Papillary / Q000401:mortality / Q000473:pathology* / Q000556:secondary / Q000628:therapy; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D017024:Chemotherapy, Adjuvant; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality / Q000473:pathology* / Q000556:secondary / Q000628:therapy; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D010994:Pleura / Q000473:pathology; D011013:Pneumonectomy; D013997:Time Factors; D016896:Treatment Outcome