title: Groin recurrence in carcinoma of the vulva: management and outcome.
abstract: The aim of the study was to investigate the management and outcome of inguinal recurrence in vulvar carcinoma patients. A retrospective chart review was conducted on 140 patients with squamous cell carcinoma of the vulva treated between 1994 and 2006. Twenty-one patients were found to have groin recurrence. Median interval between primary treatment of vulvar cancer and groin recurrence was 7 months. Three patients refused any treatment, 3 received chemotherapy, 2 inguino-pelvic radiotherapy and 13 had resection of the groin recurrence. After surgery seven patients received irradiation of the groin and pelvis, and three patients received chemotherapy. One patient died following surgery; 19 patients died of disease with the median survival after diagnosis of inguinal recurrence of 9 months. Only one patient is alive without evidence of disease at 60 months following surgery. In univariate analysis, stage and grade at diagnosis, age and performance status at the recurrent disease, and the extent of residual tumour after resection of groin recurrence were predictors for survival. Groin recurrences from vulvar carcinoma carry a poor prognosis. Multi-modal treatment may result in a palliation of the disease, and a very limited number of patients have long-term survival.
authors.affiliation: Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Bari, Bari, Italy. n.cormio@gynecology2.uniba.it
authors.forename: G
authors.initials: G
authors.lastname: Cormio
authors.forename: V
authors.initials: V
authors.lastname: Loizzi
authors.forename: C
authors.initials: C
authors.lastname: Carriero
authors.forename: A
authors.initials: A
authors.lastname: Cazzolla
authors.forename: G
authors.initials: G
authors.lastname: Putignano
authors.forename: L
authors.initials: L
authors.lastname: Selvaggi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D003131:Combined Modality Therapy / Q000379:methods; D005260:Female; D006119:Groin; D006801:Humans; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000628:therapy*; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis; D014846:Vulvar Neoplasms / Q000401:mortality / Q000628:therapy*