Patient risk factors and adverse drug interactions in the treatment of acute gouty arthritis in the elderly: a case report.
BACKGROUND
Non-steroidal anti-inflammatory drugs and corticosteroids are both used in the treatment acute gouty arthritis and may adversely interact with colchicine. Gastrointestinal toxicity of colchicine is dose-dependent and can be aggravated by drug-drug and drug-patient interactions.


METHODS
Colonic perforation associated with second-line administration of colchicine for acute gouty arthrtitis was identified in an elderly man with several comorbidities who was also treated with non-steroidal anti-inflammatory drugs and corticostroids. Underlying diverticular disease was discovered at the time of surgical therapy.


CONCLUSIONS
Initial treatment of acute gouty arthritis with non-steroidal anti-inflammatory drugs or corticosteroids may increase colchicine toxicity by subsequent pharmacokinetic and pharmacodynamic interaction in the gut wall. The literature is reviewed suggesting that diverticular disease should be included in the list of adverse event risk factors when colchicine is being considered.
Zagler
Bernhard
B
Division of Internal Medicine, Department of Medicine, Central Hospital of Bolzano, L. Böhler Street 5, I-39100 Bolzano (BZ), Italy. bernd.zagler@asbz.it
Kaneppele
Angelika
A
Pattis
Peter
P
Stockner
Ingrid
I
Sitzmann
Günther
G
Widmann
Josef
J
Pernthaler
Heinrich
H
Wiedermann
Christian J
CJ