title: Determinants and correlation of systemic and cervical concentrations of total IgA and IgG.
abstract: We compared systemic and cervical total IgA and IgG during the menstrual cycle among 154 women who attended clinic visits at follicular/early, periovulatory/mid, and luteal/late phases of menstrual cycle. Paired serum and cervical secretions were tested at each visit for total IgA and IgG using ELISA. Geometric mean titers for systemic IgA and IgG were 1.92 and 8.25 mg/mL, respectively. There were no differences in titers by menstrual cycle phase, neither were they correlated to cervical titers (rho = 0.17 and 0.16, respectively). The lack of correlation between systemic and cervical total IgA and IgG suggests that systemic concentrations are not reflective of cervical levels.
authors.affiliation: Division of Cancer Epidemiology and Genetics, Infections and Immunoepidemiology Branch, National Cancer Institute, 6120 Executive Boulevard, Suite 550, Rockville, MD 20852, USA. safaeianm@mail.nih.gov
authors.forename: Mahboobeh
authors.initials: M
authors.lastname: Safaeian
authors.forename: Troy
authors.initials: T
authors.lastname: Kemp
authors.forename: Roni T
authors.initials: RT
authors.lastname: Falk
authors.forename: Ana Cecilia
authors.initials: AC
authors.lastname: Rodriguez
authors.forename: Allan
authors.initials: A
authors.lastname: Hildesheim
authors.forename: Marcus
authors.initials: M
authors.lastname: Williams
authors.forename: Carolina
authors.initials: C
authors.lastname: Porras
authors.forename: Rolando
authors.initials: R
authors.lastname: Herrero
authors.forename: Ligia A
authors.initials: LA
authors.lastname: Pinto
mesh_terms: D000328:Adult; D002584:Cervix Uteri / Q000276:immunology*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood / Q000378:metabolism*; D007074:Immunoglobulin G / Q000097:blood / Q000378:metabolism*; D008597:Menstrual Cycle / Q000097:blood* / Q000378:metabolism*; D008875:Middle Aged
chemical_list: D007070:Immunoglobulin A; D007074:Immunoglobulin G