Isolation of flavonoids from the heartwood and resin of Prunus avium and some preliminary biological investigations.
An investigation of the constituents in heartwood and resin of Prunus avium is reported. A mini-library of structurally diverse flavanones and flavones was screened for human cytochrome P450 1A1, 3A4 and 19 (aromatase) inhibition, and for antifungal activity against a panel of pathogenic fungi. The defensive role of these natural plant flavonoids as antifungal phytoalexins and phytoanticipins is discussed.
McNulty
James
J
Department of Chemistry and Chemical Biology, McMaster University, 1280 Main Street West, Hamilton, ON, Canada L8S 4M1. jmcnult@mcmaster.ca
Nair
Jerald J
JJ
Bollareddy
Endreddy
E
Keskar
Kunal
K
Thorat
Amol
A
Crankshaw
Denis J
DJ
Holloway
Alison C
AC
Khan
Ghaznia
G
Wright
Gerard D
GD
Ejim
Linda
L
D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology*; D065607:Cytochrome P-450 Enzyme Inhibitors; D044950:Flavanones / Q000302:isolation & purification / Q000494:pharmacology*; D047309:Flavones / Q000302:isolation & purification / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects* / Q000472:pathogenicity; D027861:Prunus / Q000737:chemistry*; D012116:Resins, Plant / Q000737:chemistry*; D012717:Sesquiterpenes; D013729:Terpenes / Q000302:isolation & purification / Q000494:pharmacology*; D014934:Wood / Q000737:chemistry*; D000094162:Phytoalexins
D000935:Antifungal Agents; D065607:Cytochrome P-450 Enzyme Inhibitors; D044950:Flavanones; D047309:Flavones; D012116:Resins, Plant; D012717:Sesquiterpenes; D013729:Terpenes; D000094162:Phytoalexins