Autophagy, apoptosis, and the influenza virus M2 protein.
Viral subversion and inhibition of host cell autophagy has been documented for several viruses. In this issue of Cell Host & Microbe,Gannagé et al. (2009) show that the influenza virus M2 integral membrane protein blocks autophagosome maturation, significantly affecting host cell apoptosis.
Rossman
Jeremy S
JS
Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Evanston, IL 60208-3500, USA.
Lamb
Robert A
RA
D000818:Animals; D017209:Apoptosis; D001343:Autophagy; D006801:Humans; D009980:Influenza A virus / Q000472:pathogenicity*; D008247:Lysosomes / Q000378:metabolism* / Q000648:ultrastructure; D008954:Models, Biological; D010588:Phagosomes / Q000378:metabolism* / Q000648:ultrastructure; D014763:Viral Matrix Proteins / Q000502:physiology*; D037521:Virulence Factors / Q000502:physiology*; D000086082:Viroporin Proteins
D014763:Viral Matrix Proteins; D037521:Virulence Factors; C488937:M2 protein, Influenza A virus; D000086082:Viroporin Proteins