[Preliminary study of vulvar and vaginal intraepithelial neoplasias].
OBJECTIVE
To detect the clinical features of vulvar and vaginal intraepithelial neoplasias (VIN and VAIN, respectively).


METHODS
Total 148 women were performed vulvar or vaginal coloposcopy-directed biopsy pathology tests, from Sep. 2004 to Dec. 2007.


RESULTS
Among 148 women, vulvar or vaginal histologic results were vulvar cancer for 1, VIN or VAIN 2, 3 for 23, VIN or VAIN for 16, condyloma for 61, vulvitis and vaginitis for 47. Eighty-five percent (33/39) women with VIN or VAIN 2, 3 were more than 30 years old. Compared to women with cervical intraepithelial neoplasia (CIN), women with VIN or VAIN were older. The rate of high-risk HPV DNA in women with vulvar or vaginal lesions was 84% (84/100). VAIN occurred mainly in the upper vagina (90%, 69/75). VIN or VAIN often accompanied or followed CIN or cervical cancer (79%, 31/39), and VIN or VAIN 2, 3 often accompanied or followed CIN 2, 3 or cervical cancer (70%, 16/23).


CONCLUSIONS
Our data suggest that women with high-risk HPV infection are at risk of developing VIN or VAIN 2, 3. The vulva and vagina should be carefully inspected by colposcopic examination at the time of colposcopy for any abnormal findings.
Guo
Yan Li
YL
Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China.
Geng
Li
L
You
Ke
K
Qiao
Jie
J
Liu
Cong-rong
CR
D000328:Adult; D002278:Carcinoma in Situ / Q000473:pathology* / Q000821:virology; D003127:Colposcopy; D004279:DNA, Viral / Q000097:blood; D005260:Female; D006801:Humans; D008875:Middle Aged; D027383:Papillomaviridae / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000150:complications*; D012307:Risk Factors; D014625:Vaginal Neoplasms / Q000473:pathology* / Q000821:virology; D014846:Vulvar Neoplasms / Q000473:pathology* / Q000821:virology
D004279:DNA, Viral