title: Cytotoxic and PTP1B inhibitory activities from Erythrina abyssinica.
abstract: Bioassay-guided fractionation of the EtOAc extract of the stem bark of Erythrina abyssinica (Leguminosae) resulted in the isolation of three new (1-3), along with 12 known (4-15) pterocarpan derivatives. Their chemical structures were determined by physicochemical and spectroscopic data analysis (IR, UV, [alpha](D), CD, 1D and 2D NMR, and MS data). All the isolates were evaluated for their inhibitory effects on protein tyrosine phosphatase-1B (PTP1B), as well as their growth inhibition on MCF7, tamoxifen-resistant MCF7 (MCF7/TAMR), adriamycin-resistant MCF7 (MCF7/ADR) and MDA-MB-231 breast cancer cell lines. Compounds which exhibited PTP1B inhibitory activity (IC(50) values ranging from 4.2+/-0.2 to 19.3+/-0.3 microM) showed strong cytotoxic activity (IC(50) values from 5.6+/-0.7 to 28.0+/-0.2 microM). Our data suggested that pterocarpans could be considered as new anticancer materials by PTP1B inhibition.
authors.affiliation: College of Pharmacy, Chosun University, Gwangju 501-759, Republic of Korea.
authors.forename: Phi Hung
authors.initials: PH
authors.lastname: Nguyen
authors.forename: Thi Van Thu
authors.initials: TV
authors.lastname: Le
authors.forename: Phuong Thien
authors.initials: PT
authors.lastname: Thuong
authors.forename: Trong Tuan
authors.initials: TT
authors.lastname: Dao
authors.forename: Derek Tantoh
authors.initials: DT
authors.lastname: Ndinteh
authors.forename: Joseph Tanyi
authors.initials: JT
authors.lastname: Mbafor
authors.forename: Keon Wook
authors.initials: KW
authors.lastname: Kang
authors.forename: Won Keun
authors.initials: WK
authors.lastname: Oh
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D004895:Erythrina / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1 / Q000037:antagonists & inhibitors*; D013237:Stereoisomerism
chemical_list: D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1