title: Hydrolytic activity of histidine-containing octapeptides in water identified by quantitative screening of a combinatorial library.
abstract: A quantitative on-bead screening of a combinatorial octapeptide library revealed catalysts with hydrolytic activity in water. Histidine is an essential amino acid but the catalytic activity as well as the substrate binding affinity is also dependent on the sequence of the octapeptide.
authors.affiliation: Institute of Organic Chemistry, University of Duisburg-Essen, Universitätsstrasse 7, 45141 Essen, Germany. carsten.schmuck@uni-due.de
authors.forename: Carsten
authors.initials: C
authors.lastname: Schmuck
authors.forename: Ute
authors.initials: U
authors.lastname: Michels
authors.forename: Jürgen
authors.initials: J
authors.lastname: Dudaczek
mesh_terms: D000595:Amino Acid Sequence; D002021:Buffers; D020650:Combinatorial Chemistry Techniques; D004950:Esterases / Q000378:metabolism; D006639:Histidine; D006868:Hydrolysis; D009842:Oligopeptides / Q000032:analysis / Q000737:chemistry* / Q000378:metabolism*; D014867:Water
chemical_list: D002021:Buffers; D009842:Oligopeptides; D014867:Water; D006639:Histidine; D004950:Esterases