[Umbilical cord plasma endothelin 1 and cyclic guanosine concentrations monophosphate at delivery in pregnancy complicated by diabetes mellitus].
OBJECTIVE
The aim of the study was to assess the relationship between maternal and umbilical cord plasma concentrations of endothelin 1 (ET-1) and cyclic guanosine monophosphate (cGMP) in women with diabetes mellitus (DM).


METHODS
The study was performed on 19 neonates of women with pregestational DM, 23 neonates of women with gestational diabetes (GDM), and 18 neonates of healthy uncomplicated pregnancies.


RESULTS
We found that umbilical and maternal ET-1 and cGMP concentrations in pregestational DM or GDM women were not changed in comparison with the controls. In women without DM, positive correlations between maternal (r=0.64; p<0.005) and umbilical cord plasma (r=0.60; p<0.009) ET-1 and cGMP concentrations were found. However in pregnancies complicated by pregestational DM or GDM such associations were not observed.


CONCLUSIONS
Umbilical and maternal plasma concentrations of ET-1 and cGMP in pregnant women with pregestational diabetes as well as gestational diabetes were not changed in comparison with the non-diabetic women. In women without DM maternal and umbilical cord plasma ET-1 and cGMP concentrations showed positive correlations. In pregnancies complicated by pregestational DM or GDM maternal and umbilical cord plasma ET-1 and cGMP concentrations were not interdependent.
Swiderski
Sławomir
S
Klinika Medycyny Matczyno-Płodowej Pomorskiej Akademii Medycznej w Szczecinie. saw@ams.edu.pl
Celewicz
Zbigniew
Z
Miazgowski
Tomasz
T
D000328:Adult; D006152:Cyclic GMP / Q000097:blood*; D016640:Diabetes, Gestational / Q000097:blood*; D019332:Endothelin-1 / Q000097:blood*; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D006801:Humans; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000097:blood*; D012307:Risk Factors; D055815:Young Adult
D019332:Endothelin-1; D006152:Cyclic GMP