title: A versatile new synthetic route to 1N-hydroxyindazoles.
abstract: A new and versatile cyclization reaction affording rare 1N-hydroxyindazoles is presented. Treatment of 2-nitrobenzylamines with methanolic sodium hydroxide furnishes 1N-hydroxyindazoles regioselectively and in high yield. The reaction tolerates a range of functional groups and electronic effects.
authors.affiliation: Biovitrum AB, Discovery Research, 112 76 Stockholm, Sweden.
authors.forename: Fredrik
authors.initials: F
authors.lastname: Lehmann
authors.forename: Tobias
authors.initials: T
authors.lastname: Koolmeister
authors.forename: Luke R
authors.initials: LR
authors.lastname: Odell
authors.forename: Martin
authors.initials: M
authors.lastname: Scobie
mesh_terms: D001596:Benzylamines / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D007191:Indazoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D001596:Benzylamines; D007191:Indazoles; C030796:benzylamine