An evaluation of the activity of cephalosporins against Pseudomonas aeruginosa.
We investigated the in-vitro activity of 14 antibiotics against 200 distinct isolates of Pseudomonas aeruginosa obtained from intensive care patients. Ceftazidime was the most active beta-lactam and 16 mg/l inhibited 88% of the strains. Of 55 two-drug combinations, ceftazidime plus tobramycin was the most effective and 98.5% of strains were sensitive. Synergism between these two drugs was demonstrated for 12 of the 23 strains tested. Ceftazidime-inactivating enzymes may be induced in Ps. aeruginosa by cefoxitin.
Bauernfeind
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Max von Pettenkofer-Institut für Hygiene und Medizinische Mikrobiologie, Pettenkoferstrasse 9a, 8000 München 2, West Germany.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002442:Ceftazidime / Q000494:pharmacology*; D002511:Cephalosporins / Q000494:pharmacology*; D004338:Drug Combinations; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D001618:beta-Lactamases / Q000378:metabolism
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D004338:Drug Combinations; D002442:Ceftazidime; D001618:beta-Lactamases