Association of PTPN22 C1858T and CTLA-4 A49G polymorphisms with Type 1 Diabetes in Croatians.
In this case-control study the association between the PTPN22 1858T and CTLA-4 49G gene variants and T1D in Croatian population was examined. We found that distribution of PTPN22 C1858T and CTLA-4 A49G genotypes between T1D patient (n=102) and control (n=193) groups differ significantly (p<0.0001 and p=0.012, respectively). Moreover, although the risk alleles of both SNPs are distributed more frequently in patients, the significant difference is observed only for PTPN22 1858T allele (p<0.0001). This is therefore the first evidence that analyzed gene variants contribute to T1D pathogenesis in Croatian population.
Korolija
Marina
M
Ruder Bosković Institute, Division of Molecular Medicine, Zagreb, Croatia.
Renar
Ivana Pavlić
IP
Hadzija
Mirko
M
Medvidović
Edita Pape
EP
Pavković
Pajica
P
Jokić
Mladen
M
Hadzija
Marijana Popović
MP
D000225:Adenine; D000328:Adult; D017668:Age of Onset; D015703:Antigens, CD / Q000235:genetics*; D001786:Blood Glucose / Q000032:analysis; D060908:CTLA-4 Antigen; D017523:Croatia; D003596:Cytosine; D017931:DNA Primers; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000453:epidemiology / Q000235:genetics*; D014644:Genetic Variation; D005838:Genotype; D006442:Glycated Hemoglobin / Q000032:analysis; D006147:Guanine; D006801:Humans; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D012016:Reference Values; D018570:Risk Assessment; D013941:Thymine
D000225:Adenine; D015703:Antigens, CD; D001786:Blood Glucose; D060908:CTLA-4 Antigen; D003596:Cytosine; D017931:DNA Primers; D006442:Glycated Hemoglobin; D006147:Guanine; D013941:Thymine; C556706:CTLA4 protein, human