Ultrastable iron oxide nanoparticle colloidal suspensions using dispersants with catechol-derived anchor groups.
We have found catechol-derivative anchor groups which possess irreversible binding affinity to iron oxide and thus can optimally disperse superparamagnetic nanoparticles under physiologic conditions. This not only leads to ultrastable iron oxide nanoparticles but also allows close control over the hydrodynamic diameter and interfacial chemistry. The latter is a crucial breakthrough to assemble functionalized magnetic nanoparticles, e.g., as targeted magnetic resonance contrast agents.
Amstad
Esther
E
Laboratory of Surface Science and Technology, ETH Zurich, Switzerland.
Gillich
Torben
T
Bilecka
Idalia
I
Textor
Marcus
M
Reimhult
Erik
E
D002396:Catechols / Q000737:chemistry*; D003460:Crystallization / Q000379:methods*; D007501:Iron / Q000737:chemistry*; D046911:Macromolecular Substances / Q000737:chemistry; D008280:Magnetics; D008422:Materials Testing; D008968:Molecular Conformation; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure*; D036103:Nanotechnology / Q000379:methods*; D010316:Particle Size; D013499:Surface Properties; D013535:Suspensions / Q000737:chemistry
D002396:Catechols; D046911:Macromolecular Substances; D013535:Suspensions; D007501:Iron; C034221:catechol