title: N-terminal ProBNP distribution and correlations with biological characteristics in apparently healthy Greek population: ATTICA study.
abstract: Brain natriuretic peptides are widely used as biomarkers of cardiovascular diseases and mainly heart failure. However, these markers are often found to be high even in apparently healthy participants, and little is known about which factors contribute to physiological change in plasma brain natriuretic peptide (BNP) and amino-terminal pro-B-type natriuretic peptide (NTproBNP) concentration in general populations. In this study, a random subsample of the ATTICA study was used (486 individuals) and serum NT-proBNP was measured. Approximately 20% of the participants had no detectable NT-proBNP values. Women had higher values of NT-proBNP than men (median [25th-75th percentiles]: 30.2 [15.8-54.3] vs 14.9 [4.0-28.1] pg/mL, P < .001]. Amino-terminal pro-B-type natriuretic peptide values were positively correlated with age (rho = .140, P = .006) and inversely with body mass index (BMI; rho = -.142, P = .005), creatinine (Cr) clearance (rho = -.349, P < .001), and hemoglobin (rho = -.249, P < .001) values. Linear regression analysis revealed that gender is the main contributor of NT-proBNP levels, followed by age, BMI, and Cr values.
authors.affiliation: Department of Nutrition Science and Dietetics, Harokopio University, Athens, Greece. efragop@hua.gr
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Fragopoulou
authors.forename: Demosthenes B
authors.initials: DB
authors.lastname: Panagiotakos
authors.forename: Christos
authors.initials: C
authors.lastname: Pitsavos
authors.forename: Christina
authors.initials: C
authors.lastname: Chrysohoou
authors.forename: Tzortzis
authors.initials: T
authors.lastname: Nomikos
authors.forename: Angelos
authors.initials: A
authors.lastname: Evangelopoulos
authors.forename: Christina
authors.initials: C
authors.lastname: Katsagoni
authors.forename: John
authors.initials: J
authors.lastname: Skoumas
authors.forename: Smaragdi
authors.initials: S
authors.lastname: Antonopoulou
authors.forename: Christodoulos
authors.initials: C
authors.lastname: Stefanadis
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D015992:Body Mass Index; D015331:Cohort Studies; D003404:Creatinine / Q000378:metabolism; D005260:Female; D006115:Greece; D006304:Health Status; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D008019:Life Style; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D012016:Reference Values; D012737:Sex Factors; D012959:Socioeconomic Factors; D055815:Young Adult
chemical_list: D006454:Hemoglobins; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain; D003404:Creatinine