Finite element model of the patched human carotid.
BACKGROUND
The hemodynamic effects of carotid artery patching are not well known. Our objective was to develop a fluid-solid finite element model of the endarterectomized and patched carotid artery.


METHODS
Hyperelastic materials parameters were determined from studies of 8 cadaveric carotids. Blood flow characteristics were based on intraoperative data from a patient undergoing endarterectomy. Wall shear stress, cyclic strain and effective stress were computed as hemodynamic parameters with known association with endothelial injury, neointimal hyperplasia and atherogenesis.


RESULTS
Low wall shear stress, high cyclic strain and high effective stress were identified diffusely in the carotid bulb, at the margins around the patch and in the flow divider.


CONCLUSIONS
Endarterectomy and polytetrafluoroethylene patching produce considerable abnormalities in the hemodynamics of the repaired carotid. Advanced mechanical modeling can be used to evaluate different carotid revascularization approaches to obtain optimized biomechanical and hemodynamic results for the care of patients with carotid bifurcation disease.
Kamenskiy
Alexey V
AV
Department of Engineering Mechanics, University of Nebraska-Lincoln, Lincoln, Nebraska 68588, USA.
Pipinos
Iraklis I
II
Desyatova
Anastasia S
AS
Salkovskiy
Yuriy E
YE
Yu Kossovich
Leonid
L
Kirillova
Irina V
IV
Bockeria
Leo A
LA
Morozov
Konstantin M
KM
Polyaev
Vasiliy O
VO
Lynch
Thomas G
TG
Dzenis
Yuris A
YA
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001696:Biomechanical Phenomena; D001783:Blood Flow Velocity; D002102:Cadaver; D002339:Carotid Arteries / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery*; D016893:Carotid Stenosis / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery*; D004548:Elasticity; D016894:Endarterectomy, Carotid / Q000295:instrumentation; D005260:Female; D020342:Finite Element Analysis; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D008955:Models, Cardiovascular; D011138:Polytetrafluoroethylene; D012039:Regional Blood Flow; D013314:Stress, Mechanical; D014057:Tomography, X-Ray Computed; D018616:Ultrasonography, Doppler, Duplex
D011138:Polytetrafluoroethylene