Improvement of pain therapy in laboratory mice.
Pain of minor grades is difficult to detect in laboratory mice, because mice hide signs of injury and suffering. Low-grade post-operative pain was detected by continuous measurements of heart beat rate and variability, as well as nesting behaviours. Pain relief regimens with non-steroidal anti inflammatory drugs were shown to be effective.
Arras
Margarete
M
University of Zurich, Vetsuisse Faculty, Institute of Laboratory Animal Science, Zurich, Switzerland. arras@ltk.uzh.ch
D000827:Animal Welfare; D000818:Animals; D000830:Animals, Laboratory; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001522:Behavior, Animal / Q000187:drug effects; D005065:Euthanasia; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D051379:Mice; D009425:Nesting Behavior / Q000187:drug effects / Q000502:physiology*; D010146:Pain / Q000523:psychology; D059408:Pain Management; D010149:Postoperative Pain / Q000175:diagnosis* / Q000188:drug therapy* / Q000523:psychology
D000894:Anti-Inflammatory Agents, Non-Steroidal