Identity crisis when telomeres left unprotected.
Loss of shelterin components TRF2 or POT1a-TPP1 complex from the chromosome end triggers DNA damage response (DDR) and aberrant DNA repair events. In a recent Nature paper, Chang and colleagues reported that the DNA repair protein Mre11 contributes to multiple events at the uncapped telomere, including ataxia telangiectasia-mutated (ATM)-dependent signaling, processing of the telomeric G-tail and homologous recombination (HR).
Wu
Yun
Y
Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA. yunwu@princeton.edu
Zakian
Virginia A
VA
D000818:Animals; D004249:DNA Damage; D004260:DNA Repair; D006801:Humans; D000089804:Shelterin Complex; D016615:Telomere / Q000235:genetics / Q000378:metabolism*; D034501:Telomere-Binding Proteins / Q000235:genetics / Q000378:metabolism
C495876:ACD protein, human; D000089804:Shelterin Complex; D034501:Telomere-Binding Proteins