title: Comparison of safety and effectiveness of two different transfusion rates in children with severe anemia.
abstract: We compared the safety and efficacy of 2 transfusion regimens in children with severe anemia (hemoglobin <5 g/dL) and without overt signs of congestive heart failure requiring transfusion of packed red blood cells (PRBCs). Forty-three patients were randomly divided into 2 groups: group A and group B. The transfusion regimens consisted of continuous infusion of PRBC at a rate of 1 mL/kg/h for group A and 3 mL/kg/h for group B. The patients were closely monitored for any clinical signs of heart failure throughout transfusion. Heart and respiratory rate, and arterial blood pressure were measured hourly for 6 hours during transfusion. None of the patients developed any signs of cardiac failure during or after the transfusion. The mean heart rate, respiratory rate, diastolic and systolic blood pressure were similar in both groups throughout transfusion. Group A needed significantly more PRBC units than group B to attain the same hemoglobin increase. Transfusion of PRBC at a rate of 3 mL/kg/h, and at a rate of 1 mL/kg/h, is a safe regimen for children with severe anemia of gradual onset requiring transfusion therapy.
authors.affiliation: Division of Pediatric Cardiology, Ataturk University, Medical School, Erzurum, Turkey.
authors.forename: Hasim
authors.initials: H
authors.lastname: Olgun
authors.forename: Mustafa
authors.initials: M
authors.lastname: Buyukavci
authors.forename: Oguzhan
authors.initials: O
authors.lastname: Sepetcigil
authors.forename: Zuhal Keskin
authors.initials: ZK
authors.lastname: Yildirim
authors.forename: Mehmet
authors.initials: M
authors.lastname: Karacan
authors.forename: Naci
authors.initials: N
authors.lastname: Ceviz
mesh_terms: D000293:Adolescent; D000740:Anemia / Q000503:physiopathology* / Q000628:therapy*; D001794:Blood Pressure; D002648:Child; D002675:Child, Preschool; D017707:Erythrocyte Transfusion; D005260:Female; D006333:Heart Failure / Q000517:prevention & control; D006339:Heart Rate; D006801:Humans; D007223:Infant; D008297:Male; D008991:Monitoring, Physiologic; D015656:Respiratory Mechanics; D012449:Safety