Rapid clinical progression to AIDS and death in a persistently seronegative HIV-1 infected heterosexual young man.
Seronegative HIV-1 infection has important implications for diagnosis and prevention. We describe a case of HIV-1 infection without seroconversion and fast progression to AIDS and death.Genetic and phylogenetic analysis indicated that the patient was infected with a CRF14_BG-like strain selectively transmitted by his seropositive sexual partner. The results suggest a massive infection with a highly aggressive CRF14_BG-like strain and/or the presence of an unidentified immunological deficiency that has prevented the formation of HIV-1-specific antibodies.
Bártolo
Inês
I
Unidade dos Retrovírus e Infecções Associadas, Centro de Patogénese Molecular, Faculdade de Farmácia de Lisboa, Lisbon.
Camacho
Ricardo
R
Barroso
Helena
H
Bezerra
Victor
V
Taveira
Nuno
N
D018450:Disease Progression; D017809:Fatal Outcome; D006679:HIV Seropositivity / Q000821:virology*; D015497:HIV-1; D006801:Humans; D008297:Male; D016017:Odds Ratio; D012307:Risk Factors; D012725:Sexual Behavior; D012747:Sexual Partners; D055815:Young Adult