title: Chromosomal instability: a composite phenotype that influences sensitivity to chemotherapy.
abstract: Chromosomal instability (CIN) is defined as continual gain or loss of whole chromosomes or fractions of chromosomes and is a major cause of the genomic instability that characterizes most solid tumors. CIN is associated with intrinsic resistance to taxanes, acquired multidrug resistance and poor prognosis in many solid tumors, although recent evidence has shown that platinum agents, such as carboplatin, may specifically target CIN cancers.
authors.affiliation: Translational Cancer Therapeutics Laboratory, Cancer Research UK, London Research Institute, London, UK.
authors.forename: Sarah E
authors.initials: SE
authors.lastname: McClelland
authors.forename: Rebecca A
authors.initials: RA
authors.lastname: Burrell
authors.forename: Charles
authors.initials: C
authors.lastname: Swanton
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology; D045744:Cell Line, Tumor; D043171:Chromosomal Instability; D020090:Chromosome Segregation; D019008:Drug Resistance, Neoplasm; D006801:Humans; D018386:Kinetochores; D008938:Mitosis; D009369:Neoplasms / Q000188:drug therapy; D043823:Taxoids / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D043823:Taxoids