title: Nonapical tako-tsubo cardiomyopathy associated with coronary slow flow: a case report and review of the literature.
abstract: The exact pathophysiology of tako-tsubo cardiomyopathy (TTC) is unclear. A nonapical form of TTC precipitated by emotional stress is presented. Findings on 12 lead ECG and coronary angiogram are discussed. The role of specialized investigations such as cardiac MRI and tissue Doppler imaging are reviewed. We then examine the probable molecular explanations for this condition and suggest a probable molecular mechanism based on animal studies. Future therapeutic options are also briefly discussed.
authors.affiliation: Department of Cardiovascular Sciences, Glenfield Hospital, University Hospitals of Leicester NHS Trust, Groby Road, Leicester LE3 9QP, United Kingdom. uk12@le.ac.uk
authors.forename: Unni
authors.initials: U
authors.lastname: Krishnan
authors.forename: Amanda
authors.initials: A
authors.lastname: Zacharzewski
authors.forename: Matthias
authors.initials: M
authors.lastname: Schmitt
mesh_terms: D000818:Animals; D017023:Coronary Angiography; D003326:Coronary Circulation; D015150:Echocardiography, Doppler; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D054318:No-Reflow Phenomenon / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D011237:Predictive Value of Tests; D013315:Stress, Psychological / Q000150:complications* / Q000503:physiopathology; D054549:Takotsubo Cardiomyopathy / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology