title: Immunological and biochemical correlates of adjunctive dexamethasone in Vietnamese adults with bacterial meningitis.
abstract: Adjunctive treatment to improve outcome from bacterial meningitis has centered on dexamethasone. Among Vietnamese patients with bacterial meningitis, cerebrospinal fluid (CSF) opening pressure and CSF:plasma glucose ratios were significantly improved and levels of CSF cytokines interleukin (IL)-6, IL-8, and IL-10 and were all statistically significantly lower after treatment in patients who were randomized to dexamethasone, compared with levels in patients who received placebo.
authors.affiliation: Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.
authors.forename: Nguyen Thi Hoang
authors.initials: NT
authors.lastname: Mai
authors.forename: Trung Vu
authors.initials: TV
authors.lastname: Tuan
authors.forename: Marcel
authors.initials: M
authors.lastname: Wolbers
authors.forename: Dang Minh
authors.initials: DM
authors.lastname: Hoang
authors.forename: Tran Vu Thieu
authors.initials: TV
authors.lastname: Nga
authors.forename: Tran Thi Hong
authors.initials: TT
authors.lastname: Chau
authors.forename: Ly Van
authors.initials: LV
authors.lastname: Chuong
authors.forename: Dinh Xuan
authors.initials: DX
authors.lastname: Sinh
authors.forename: Ho Dang Trung
authors.initials: HD
authors.lastname: Nghia
authors.forename: Nguyen Duy
authors.initials: ND
authors.lastname: Phong
authors.forename: Nguyen Hoan
authors.initials: NH
authors.lastname: Phu
authors.forename: To Song
authors.initials: TS
authors.lastname: Diep
authors.forename: Hoang Thi Thanh
authors.initials: HT
authors.lastname: Hang
authors.forename: Nguyen van Vinh
authors.initials: Nv
authors.lastname: Chau
authors.forename: Jeremy
authors.initials: J
authors.lastname: Farrar
authors.forename: Constance
authors.initials: C
authors.lastname: Schultsz
authors.forename: Tran Tinh
authors.initials: TT
authors.lastname: Hien
authors.forename: Cameron P
authors.initials: CP
authors.lastname: Simmons
mesh_terms: D000293:Adolescent; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D044466:Asian People; D002648:Child; D003907:Dexamethasone / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000134:cerebrospinal fluid; D015850:Interleukin-6 / Q000134:cerebrospinal fluid; D016209:Interleukin-8 / Q000134:cerebrospinal fluid; D008297:Male; D016920:Meningitis, Bacterial / Q000134:cerebrospinal fluid* / Q000188:drug therapy*; D008875:Middle Aged; D014744:Vietnam; D055815:Young Adult
chemical_list: D000893:Anti-Inflammatory Agents; D015850:Interleukin-6; D016209:Interleukin-8; D016753:Interleukin-10; D003907:Dexamethasone