Luteolin increases the expression of GRP94 in HeLa cells.
We found increased expression of GRP94, the 94-kDa glucose-regulated protein, in HeLa cells 24 h after treatment with luteolin. Luteolin increased the levels of GRP94 mRNA and protein, but it did not increase the expression of unfolded protein response (UPR)-regulated genes. In addition, luteolin also enhanced GRP94 promoter activity, suggesting that it enhances the expression of GRP94 at the transcriptional level, not via the UPR signaling pathway.
Hu
Gaofeng
G
Department of Environmental Biochemistry, Graduate School of Medicine, Chiba University, Japan.
Suzuki
Toshikazu
T
Dong
Mei
M
Shi
Qin-Wen
QW
Cong
Bing
B
Suzuki
Nobuo
N
D018840:HSP70 Heat-Shock Proteins / Q000235:genetics* / Q000378:metabolism*; D006367:HeLa Cells; D006801:Humans; D047311:Luteolin / Q000494:pharmacology*; D008565:Membrane Proteins / Q000235:genetics* / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D015854:Up-Regulation / Q000187:drug effects*
D018840:HSP70 Heat-Shock Proteins; D008565:Membrane Proteins; D012333:RNA, Messenger; C018551:glucose-regulated proteins; D047311:Luteolin