title: Risk of progression in smouldering myeloma and monoclonal gammopathies of unknown significance: comparative analysis of the evolution of monoclonal component and multiparameter flow cytometry of bone marrow plasma cells.
abstract: The present study explored the impact of two novel criteria; having >95% abnormal plasma cells by flow cytometry at diagnosis and the evolving subtype of the disease, as predictors of progression in 61 smouldering multiple myeloma (SMM) and 311 monoclonal gammopathy of unknown significance (MGUS) patients. Although both criteria were of prognostic value, the risk of progression was better identified by immunophenotyping [Hazard Ratio (HR) 6.2 and 17.2 for SMM and MGUS, respectively] than evolving subtype, which had independent prognostic value only in MGUS (HR 3.6). Immunophenotyping discriminated the different risk of progression within the evolving and non-evolving subgroups of SMM (P = 0.01) and MGUS (P < 0.001).
authors.affiliation: Department of Haematology, University Hospital.
authors.forename: Ernesto
authors.initials: E
authors.lastname: Pérez-Persona
authors.forename: Gema
authors.initials: G
authors.lastname: Mateo
authors.forename: Ramón
authors.initials: R
authors.lastname: García-Sanz
authors.forename: María-Victoria
authors.initials: MV
authors.lastname: Mateos
authors.forename: Natalia
authors.initials: N
authors.lastname: de Las Heras
authors.forename: Alfonso García
authors.initials: AG
authors.lastname: de Coca
authors.forename: José M
authors.initials: JM
authors.lastname: Hernández
authors.forename: Josefina
authors.initials: J
authors.lastname: Galende
authors.forename: Guillermo
authors.initials: G
authors.lastname: Martín-Nuñez
authors.forename: Abelardo
authors.initials: A
authors.lastname: Bárez
authors.forename: José M
authors.initials: JM
authors.lastname: Alonso
authors.forename: Alejandro
authors.initials: A
authors.lastname: Martín
authors.forename: Consuelo
authors.initials: C
authors.lastname: López-Berges
authors.forename: Alberto
authors.initials: A
authors.lastname: Orfao
authors.forename: Jesús F
authors.initials: JF
authors.lastname: San Miguel
authors.forename: María-Belén
authors.initials: MB
authors.lastname: Vidriales
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018450:Disease Progression; D005260:Female; D005434:Flow Cytometry / Q000379:methods; D006801:Humans; D016130:Immunophenotyping; D008297:Male; D008875:Middle Aged; D008998:Monoclonal Gammopathy of Undetermined Significance / Q000276:immunology* / Q000473:pathology; D009101:Multiple Myeloma / Q000276:immunology* / Q000473:pathology; D010950:Plasma Cells / Q000276:immunology*; D011379:Prognosis