title: Association of codon 10 polymorphism of the transforming growth factor beta 1 gene with prostate cancer and hyperplasia in an Iranian population.
abstract: BACKGROUND
  Genetic polymorphisms in codons 10 of the transforming growth factor beta(1) (TGF-beta(1)) gene TGFB1 have been shown to be associated with the production of high or low TGF-beta(1) levels. The role of this polymorphism in the development of prostate cancer and hyperplasia was investigated.
  
  
  METHODS
  Using the allele-specific oligonucleotide polymerase chain reaction method, the association between the polymorphism at codon 10 of the TGFB1 gene and the risk of prostate cancer (PCa) or benign prostate hyperplasia (BPH) was determined.
  
  
  RESULTS
  Significant differences in the CC versus TT genotype distribution between PCa patients and male controls (p = 0.009), and between BPH patients and male controls (p = 0.005) were noted. Males with the TT genotype had a 1.67-fold increased risk of PCa and those with the TC/TT genotype had a 1.14-fold increased risk of PCa; males with the TT genotype had a 1.54-fold increased risk of BPH and those a with the TT/TC genotype had a 1.06-fold increased risk of BPH compared with those with the CC genotype.
  
  
  CONCLUSIONS
  Based on our findings, it was possible to conclude that the codon 10 polymorphism in TGFB1 may have a significant influence on the development of PCa and BPH and that the T allele of the TGFB1 gene has a dominant effect on the development of PCa and BPH.
authors.affiliation: Department of Genetics, Urmia Medical Science University, Urmia, Iran. davood_omrani@umsu.ac.ir
authors.forename: Mir Davood
authors.initials: MD
authors.lastname: Omrani
authors.forename: Soroush
authors.initials: S
authors.lastname: Taghipour-Bazargani
authors.forename: Shaker
authors.initials: S
authors.lastname: Salari-Lak
authors.forename: Morteza
authors.initials: M
authors.lastname: Bagheri
mesh_terms: D000368:Aged; D003062:Codon; D006801:Humans; D007492:Iran; D008297:Male; D011110:Polymorphism, Genetic; D011470:Prostatic Hyperplasia / Q000235:genetics*; D011471:Prostatic Neoplasms / Q000235:genetics*; D053773:Transforming Growth Factor beta1 / Q000235:genetics*
chemical_list: D003062:Codon; D053773:Transforming Growth Factor beta1