title: Reproductive and developmental toxicity evaluation of a purified Arabinogalactan-Protein (AGP) composition in Wistar rats.
abstract: A purified Arabinogalactan-Protein composition (LL-4218) was prepared from the leaves of Argemone mexicana to treat psoriasis. The effect of (LL-4218) was evaluated on reproductive (male and female fertility) and developmental toxicity in rats. LL-4218 was administered orally at the doses of 250, 500 and 1000 mg kg(-1). The results showed that LL-4218 did not produce any significant dose related changes in reproductive and developmental toxicity studies. Therefore, it is concluded that LL-4218 did not produce any significant toxic effect on reproduction and developmental parameters of rats and NOAEL for reproductive and developmental toxicity studies in rats was 1000 mg kg(-1).
authors.affiliation: Novel Drug Discovery and Development (NDDD), Lupin Ltd., 46A/47A, Nande Village, Mulshi Taluka, Pune 411042, India.
authors.forename: Salim
authors.initials: S
authors.lastname: Tamboli
authors.forename: Sudershan
authors.initials: S
authors.lastname: Arora
authors.forename: Upendra
authors.initials: U
authors.lastname: Bhatnagar
authors.forename: Gururaj
authors.initials: G
authors.lastname: Vishwase
authors.forename: Minakshi
authors.initials: M
authors.lastname: Singh
mesh_terms: D000818:Animals; D031674:Argemone / Q000737:chemistry*; D005260:Female; D005298:Fertility / Q000187:drug effects*; D047109:Fetal Development / Q000187:drug effects*; D005685:Galactans / Q000302:isolation & purification / Q000633:toxicity*; D008297:Male; D010936:Plant Extracts / Q000737:chemistry / Q000633:toxicity*; D010940:Plant Proteins / Q000302:isolation & purification / Q000633:toxicity*; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar
chemical_list: D005685:Galactans; D010936:Plant Extracts; D010940:Plant Proteins; C005653:arabinogalactan