title: Bronchial hyperreactivity in non-atopic children with asthma and reflux: effect of anti-reflux treatment.
abstract: BACKGROUND
  The prevalence of bronchial hyperreactivity (BHR) or the effect of anti-reflux treatment on BHR in children with asthma and gastroesophageal reflux disease (GERD) is not known.
  
  
  METHODS
  Thirty non-atopic children with persistent asthma were studied. Extended esophageal pH monitoring was used to diagnose GERD and methacholine challenge test (MCT) was used as a marker of BHR and performed before and 2 years after anti-GERD treatment.
  
  
  RESULTS
  Of the 21 patients positive for GERD (group A), 15 had positive MCT suggesting BHR. Of the 9 patients negative for GERD (group B), 5 had positive MCT. On repeat testing 2 years later, 11/15 group A patients and 3/5 group B patients tested negative for BHR. Group A patients were receiving fewer asthma medications and experienced fewer exacerbations than Group B patients.
  
  
  CONCLUSIONS
  BHR is prevalent in children with asthma and GERD and improves with anti-GERD treatment.
authors.affiliation: West Jefferson Medical Center, Marrero, LA 70072, USA. vkhoshoo@sbcglobal.net
authors.forename: Vikram
authors.initials: V
authors.lastname: Khoshoo
authors.forename: Sopan
authors.initials: S
authors.lastname: Mohnot
authors.forename: Robert
authors.initials: R
authors.lastname: Haydel
authors.forename: Emilio
authors.initials: E
authors.lastname: Saturno
authors.forename: Dean
authors.initials: D
authors.lastname: Edell
authors.forename: Aaron
authors.initials: A
authors.lastname: Kobernick
mesh_terms: D000293:Adolescent; D001249:Asthma / Q000150:complications / Q000453:epidemiology / Q000503:physiopathology*; D016535:Bronchial Hyperreactivity / Q000150:complications* / Q000453:epidemiology*; D001985:Bronchial Provocation Tests; D002648:Child; D050782:Esophageal pH Monitoring; D005764:Gastroesophageal Reflux / Q000150:complications* / Q000188:drug therapy* / Q000453:epidemiology; D006801:Humans; D015995:Prevalence; D054328:Proton Pump Inhibitors / Q000627:therapeutic use*
chemical_list: D054328:Proton Pump Inhibitors