[Clinical features of cytomegalovirus pneumonia after allogeneic hematopoietic stem cell transplantation].
OBJECTIVE
To analyze the clinical features and prognosis of cytomegalovirus (CMV) pneumonia after allogeneic hematopoietic stem-cell transplantation (allo-HSCT) under the preemptive therapy based on monitoring CMV-DNA level quantificationally.


METHODS
We studied 750 patients underwent allo-HSCT from Jan, 2005 to Aug, 2008. A total of 22 patients who developed into CMV pneumonia were analyzed retrospectively.


RESULTS
Twenty-four episodes of CMV pneumonia occurred in the 22 patients (2.9%) and the majority of them developed into CMV pneumonia average 51 days ( 30 to 180 days) after allo-HSCT. Of the 22 patients 16 (72.7%) underwent CMV-DNA emia and 6 remained CMV-PCR negative throughout the course of the disease. The pulmonary CT manifestation of 23 episodes showed specific features of interstitial changes, including diffused or patchy ground-glass opacities. Better curative effects were obtained using antivirus drugs combined with glucocorticoid and the total curative ratio of CMV pneumonia was 83.3%. Male and the occurrence of severe acute graft-versus-host disease seemed to be correlated with an unfavorable outcome through univariate analysis(P=0.034, P=0.023).


CONCLUSIONS
Making a diagnosis as soon as possible and appropriate therapy will improve the outcome of patients with CMV pneumonia markedly.
Zhao
Xiao Su
XS
Institute of Hematology, Peking University People's Hospital, Beijing 100044, China.
Liu
Dai Hong
DH
Xu
Lan Ping
LP
Chen
Huan
H
Chen
Yu Hong
YH
Zhang
Xiao Hui
XH
Han
Wei
W
Wang
Yu
Y
Liu
Kai Yan
KY
Huang
Xiao Jun
XJ
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003587:Cytomegalovirus / Q000302:isolation & purification; D003586:Cytomegalovirus Infections / Q000175:diagnosis* / Q000209:etiology*; D004279:DNA, Viral / Q000097:blood; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D007938:Leukemia / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011024:Pneumonia, Viral / Q000175:diagnosis / Q000209:etiology*; D016133:Polymerase Chain Reaction; D011379:Prognosis; D012189:Retrospective Studies; D014184:Transplantation, Homologous; D055815:Young Adult
D004279:DNA, Viral