Genetic factors associated with intestinal metaplasia in a high risk Singapore-Chinese population: a cohort study.
BACKGROUND
Intestinal metaplasia (IM) is an important precursor lesion in the development of gastric cancer (GC). The aim of this study was to investigate genetic factors previously linked to GC risk for their possible association with IM. A total of 18 polymorphisms in 14 candidate genes were evaluated in a Singapore-Chinese population at high risk of developing GC.


METHODS
Genotype frequencies were compared between individuals presenting with (n = 128) or without (n = 246) IM by both univariate and multivariate analysis.


RESULTS
Carriers of the NQO1 609 T allele showed an association with IM in individuals who were seropositive for Helicobacter pylori (HP+; OR = 2.61, 95%CI: 1.18-5.80, P = .018). The IL-10 819 C allele was also associated with IM in HP+ individuals (OR = 2.32, 95%CI: 1.21-4.43, P = 0.011), while the PTPN11 A allele was associated with IM in HP- individuals (OR = 2.51, 95%CI: 1.16-5.40, P = 0.019), but showed an inverse association in HP+ subjects (OR = 0.46, 95%CI: 0.21-0.99, P = 0.048).


CONCLUSIONS
Polymorphisms in NQO1, IL-10 and PTPN11, in combination with HP status, could be used to identify individuals who are more likely to develop IM and therefore GC.
Zhu
Feng
F
Department of Medicine, National University of Singapore, Singapore, Singapore. mdczhuf@nus.edu.sg
Loh
Marie
M
Hill
Jeffrey
J
Lee
Sumarlin
S
Koh
King Xin
KX
Lai
Kin Wai
KW
Salto-Tellez
Manuel
M
Iacopetta
Barry
B
Yeoh
Khay Guan
KG
Soong
Richie
R
D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D002681:China / Q000208:ethnology; D015331:Cohort Studies; D018450:Disease Progression; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology* / Q000208:ethnology / Q000235:genetics*; D005838:Genotype; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D007422:Intestines / Q000473:pathology*; D008297:Male; D008679:Metaplasia / Q000453:epidemiology / Q000235:genetics / Q000473:pathology; D008875:Middle Aged; D015999:Multivariate Analysis; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11 / Q000235:genetics*; D012307:Risk Factors; D012846:Singapore / Q000453:epidemiology; D013274:Stomach Neoplasms / Q000473:pathology
D016753:Interleukin-10; D016660:NAD(P)H Dehydrogenase (Quinone); C447479:NQO1 protein, human; C516724:PTPN11 protein, human; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11