title: The central role of Bcl-3 in atopic dermatitis.
abstract: Cytokines and hormones are essential mediators in the regulation of antimicrobial peptide and protein (AMP) levels during host defense responses. In this issue, Büchau et al. identify and characterize B-cell leukemia-3 as an important modulator of AMP expression during the innate immune response in keratinocytes as well as in the chronic inflammatory skin disorder atopic dermatitis.
authors.affiliation: Department of Laboratory Medicine, Lund University, Malmö University Hospital, Malmö, Sweden.
authors.forename: Ramin
authors.initials: R
authors.lastname: Massoumi
mesh_terms: D023181:Antimicrobial Cationic Peptides / Q000235:genetics / Q000502:physiology; D000081242:B-Cell Lymphoma 3 Protein; D003876:Dermatitis, Atopic / Q000209:etiology* / Q000276:immunology / Q000628:therapy; D006801:Humans; D007113:Immunity, Innate; D015603:Keratinocytes / Q000276:immunology; D011518:Proto-Oncogene Proteins / Q000502:physiology*; D014157:Transcription Factors / Q000502:physiology*; D014807:Vitamin D / Q000008:administration & dosage; D054804:Cathelicidins
chemical_list: D023181:Antimicrobial Cationic Peptides; D000081242:B-Cell Lymphoma 3 Protein; C000631344:BCL3 protein, human; D011518:Proto-Oncogene Proteins; D014157:Transcription Factors; D014807:Vitamin D; D054804:Cathelicidins