Synthesis and antimicrobial activity of 7-(2-substituted phenylthiazolidinyl)-benzopyran-2-one derivatives.
A series of 7-(2-substituted phenylthiazolidinyl)-benzopyran-2-one derivatives have been synthesized by reaction of 7-amino-4-methyl-benzopyran-2-one (1) with an appropriate substituted aldehydes to obtain various Schiff bases (3a-k) which on treatment with thioglycolic acid afforded the title compounds (4a-k). Purity of the compounds has been confirmed by TLC. Structure of these compounds were established on the bases IR, 1H NMR, 13C NMR and Mass spectral data. Schiff bases and title compounds were evaluated for antibacterial and antifungal activities against various bacterial and fungal strains. The results showed that compounds 3d, 3f, 4d, 4f and 4i (100 microg/ml) exhibited good antibacterial and antifungal activity as that of standard antibiotics Ciprofloxacin and Griseofulvin.
Ronad
Pradeepkumar M
PM
Department of Pharmaceutical chemistry, KLE's College of Pharmacy, Vidyanagar, Hubli-580031, Karnataka, India. ronad_p@rediffmail.com
Noolvi
Malleshappa N
MN
Sapkal
Sheetal
S
Dharbhamulla
Satyanarayana
S
Maddi
Veeresh S
VS
D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D003374:Coumarins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects; D013057:Spectrum Analysis; D053778:Thiazolidines / Q000737:chemistry*
D000890:Anti-Infective Agents; D003374:Coumarins; D053778:Thiazolidines