title: Sex determination: two copies for one cock.
abstract: The molecular mechanism of sex determination in birds has long remained mysterious. Genetically male chicken embryos, which have two Z sex chromosomes, develop female gonads when the Z chromosome-linked gene DMRT1 is knocked out. This suggests that sex is determined by Z chromosome dosage.
authors.affiliation: Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Norbyvägen 18D, SE-752 36 Uppsala, Sweden. Hans.Ellegren@ebc.uu.se
authors.forename: Hans
authors.initials: H
authors.lastname: Ellegren
mesh_terms: D000818:Animals; D002645:Chickens / Q000235:genetics* / Q000502:physiology; D005260:Female; D018628:Gene Dosage / Q000235:genetics*; D008297:Male; D012730:Sex Chromosomes / Q000235:genetics*; D019849:Sex Determination Processes; D014157:Transcription Factors / Q000235:genetics*
chemical_list: C110547:DMRT1 protein; D014157:Transcription Factors