Platelet-activating factor levels of serum and gingival crevicular fluid in nonsmoking patients with periodontitis and/or coronary heart disease.
The purpose of the present study was to investigate systemic and local levels of platelet-activating factor (PAF), a potent proinflammatory mediator implicated in cardiovascular pathophysiology in adult nonsmoking patients with periodontitis with or without coronary heart disease (CHD). Eighty-seven volunteers, 25 periodontitis patients, 19 periodontitis with CHD patients, 19 CHD patients, and 24 healthy controls were included, and periodontal conditions were assessed. Gingival crevicular fluid (GCF) and venous blood were collected, and PAF levels were measured by enzyme-linked immunosorbent assay. PAF levels in serum (303.3 ± 204 pg/ml) and in GCF (26.3 ± 6 pg/μl) of the periodontitis group with CHD, the periodontitis group (serum, 302.4 ± 241 pg/ml and GCF, 26.3 ± 8 pg/μl) and the CHD group (serum, 284.7 ± 192 pg/ml and GCF, 20.8 ± 6 pg/μl) were significantly higher than the healthy control group (serum, 65.4 ± 35 pg/ml and GCF, 7.7 ± 3 pg/μl; p < 0.05). In summary, the present study could demonstrate that in patients with periodontitis, the inflammatory mediator PAF is released into serum at least in the same range as for patients with coronary heart disease. However, no additive effects were seen when both conditions were present.
Chen
Hui
H
Department of Conservative Dentistry and Periodontics, Affiliated Hospital of Stomatology, Medical College, Zhejiang University, Hangzhou, People's Republic of China.
Zheng
Pei
P
Zhu
Haihua
H
Zhu
Jianhua
J
Zhao
Lili
L
El Mokhtari
Nour Eddine
NE
Eberhard
Jörg
J
Lins
Markus
M
Jepsen
Søren
S
D000328:Adult; D016301:Alveolar Bone Loss / Q000097:blood / Q000378:metabolism; D003327:Coronary Disease / Q000097:blood* / Q000150:complications / Q000378:metabolism; D003774:Dental Plaque Index; D005260:Female; D005883:Gingival Crevicular Fluid / Q000737:chemistry*; D005884:Gingival Hemorrhage / Q000097:blood / Q000378:metabolism; D006801:Humans; D018836:Inflammation Mediators / Q000032:analysis / Q000097:blood; D008297:Male; D008875:Middle Aged; D017622:Periodontal Attachment Loss / Q000097:blood / Q000378:metabolism; D010514:Periodontal Pocket / Q000097:blood / Q000378:metabolism; D010518:Periodontitis / Q000097:blood* / Q000150:complications / Q000378:metabolism; D010972:Platelet Activating Factor / Q000032:analysis*; D013440:Sulfides / Q000032:analysis; D055815:Young Adult
D018836:Inflammation Mediators; D010972:Platelet Activating Factor; D013440:Sulfides