title: Role of IL-10 -1082, IFN-gamma +874, and TNF-alpha -308 genes polymorphisms in suicidal behavior.
abstract: In this study, it was determined whether the IL-10 -1082, IFN-gamma +874, and TNF-alpha -308 polymorphisms were associated with suicidal behavior. One hundred forty five patients with suicidal behavior and 160 normal individuals were genotyped for IL-10 -1082, IFN-gamma +874, and TNF-alpha -308 polymorphisms using ASO-PCR method. TNF-alpha -308 G/G genotype has been increased in males with completed suicide behavior versus control group (p value = 0.017). IL-10 -1082 A/A genotype is higher in both male and female suicide completed groups (p value = 0.017). IFN-gamma (+874) A/A genotype was significantly higher in males with completed suicide behavior versus normal male control (p value = 0.027). It can be concluded that IL-10, IFN-gamma, and TNF-alpha polymorphisms may play a role in suicidal behavior.
authors.affiliation: Department of Genetics, Urmia University of Medical Sciences, Motahari Hospital, Urmia, Iran. davood_omrani@umsu.ac.ir
authors.forename: Mir Davood
authors.initials: MD
authors.lastname: Omrani
authors.forename: Behzad
authors.initials: B
authors.lastname: Bushehri
authors.forename: Morteza
authors.initials: M
authors.lastname: Bagheri
authors.forename: Shaker
authors.initials: S
authors.lastname: Salari-Lak
authors.forename: Azize
authors.initials: A
authors.lastname: Alipour
authors.forename: Mohamad-Reza
authors.initials: MR
authors.lastname: Anoshae
authors.forename: Reza
authors.initials: R
authors.lastname: Massomi
mesh_terms: D000328:Adult; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D007371:Interferon-gamma / Q000235:genetics*; D016753:Interleukin-10 / Q000235:genetics*; D007492:Iran; D008297:Male; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors; D016728:Self-Injurious Behavior / Q000235:genetics*; D013405:Suicide; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*; D055815:Young Adult
chemical_list: D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D007371:Interferon-gamma