[Three cases of isocyanate-induced hypersensitivity pneumonitis with different HRCT findings].
We reported 3 cases of hypersensitivity pneumonitis who had been exposed to polyurethane material containing diphenylmethane diisocyanate (MDI) for 1-12 weeks. They had cough, fever and dyspnea before admission. All 3 cases were diagnosed immunologically using anti-MDI antibodies. Chest HRCT findings of the 3 cases were different. Case 1 showed an organizing pneumonia (OP) pattern : patchy peripheral consolidation with air bronchogram and ground-glass opacities (GGO), and case 2 showed a nonspecific interstitial pneumonia (NSIP) pattern : consolidation and reticular shadows in both lower lobes. In addition, case 3 showed a hypersensitivity pneumonitis (HP) pattern : centrilobular GGO and diffuse granular shadows. All cases were successfully treated by corticosteroids alone. This suggests that different amounts of inhaled antigen can cause different HRCT findings.
Hara
Shintaro
S
Second Department of Internal Medicine, Nagasaki University School of Medicine.
Yamamoto
Kazuko
K
Yoda
Aya
A
Nakayama
Seiko
S
Sakamoto
Noriho
N
Ishimatsu
Yuji
Y
Mukae
Hiroshi
H
Kohno
Shigeru
S
D000542:Alveolitis, Extrinsic Allergic / Q000139:chemically induced* / Q000000981:diagnostic imaging* / Q000188:drug therapy; D006801:Humans; D017953:Isocyanates / Q000009:adverse effects* / Q000276:immunology; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage; D008875:Middle Aged; D009784:Occupational Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging*; D016273:Occupational Exposure / Q000009:adverse effects*; D020551:Pulse Therapy, Drug; D011856:Radiographic Image Enhancement; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D001559:Benzhydryl Compounds
D017953:Isocyanates; D008775:Methylprednisolone; C005969:4,4'-diphenylmethane diisocyanate; D001559:Benzhydryl Compounds