Use of antipsychotic medication in chemotherapy-induced nausea and vomiting.
Nausea and vomiting continue to present significant problems for cancer patients undergoing chemotherapy. Initial work suggested an important role for central dopamine transmission in the underlying pathophysiology. However, recent evidence has implicated central and peripheral serotonin release. Although the implementation of 5-HT(3) receptor antagonists has resulted in significant improvement in acute symptoms of nausea and vomiting, they have not demonstrated optimal efficacy in anticipatory and delayed emetic syndromes and are significantly more expensive than other antiemetic therapies. The use of typical antipsychotic medication to reduce nausea and vomiting in cancer patients is discussed, as is the potential efficacy of newer atypical antipsychotics, which have activity at receptors implicated in the control of chemotherapy-induced nausea and vomiting and demonstrate an improved side-effect profile.
Roffman
Joshua L
JL
The Massachusetts General Hospital/Harvard Medical School, Massachusetts General Hospital, Department of Psychiatry, 55 Fruit Street, Boston, MA 02114, USA. jroffman@partners.org
Pirl
William F
WF