title: Xanalteric acids I and II and related phenolic compounds from an endophytic Alternaria sp. isolated from the mangrove plant Sonneratia alba.
abstract: Two new 10-oxo-10H-phenaleno[1,2,3-de]chromene-2-carboxylic acids, xanalteric acids I (1) and II (2), and 11 known secondary metabolites were obtained from extracts of the endophytic fungus Alternaria sp., isolated from the mangrove plant Sonneratia alba collected in China. The metabolites were confirmed to be of fungal origin, and the structures of the new natural products were unambiguously elucidated on the basis of extensive one- and two-dimensional NMR spectroscopic studies and mass spectrometric analysis. The two new compounds 1 and 2 exhibited weak antibiotic activity against multidrug-resistant Staphylococcus aureus. Altenusin (3) displayed broad antimicrobial activity against several additional multidrug-resistant bacterial and fungal strains.
authors.affiliation: Institut für Pharmazeutische Biologie und Biotechnologie, Heinrich-Heine-Universität Düsseldorf, Universitätsstrasse 1, Geb. 26.23, 40225 Düsseldorf, Germany.
authors.forename: Julia
authors.initials: J
authors.lastname: Kjer
authors.forename: Victor
authors.initials: V
authors.lastname: Wray
authors.forename: RuAngelie
authors.initials: R
authors.lastname: Edrada-Ebel
authors.forename: Rainer
authors.initials: R
authors.lastname: Ebel
authors.forename: Alexander
authors.initials: A
authors.lastname: Pretsch
authors.forename: Wenhan
authors.initials: W
authors.lastname: Lin
authors.forename: Peter
authors.initials: P
authors.lastname: Proksch
mesh_terms: D000528:Alternaria / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001230:Aspergillus / Q000187:drug effects; D001419:Bacteria / Q000187:drug effects; D001578:Benzopyrans / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D002681:China; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D027822:Myrtaceae / Q000382:microbiology*; D019906:Nuclear Magnetic Resonance, Biomolecular; D013237:Stereoisomerism
chemical_list: D000900:Anti-Bacterial Agents; D001578:Benzopyrans; C545428:xanalteric acid I