Distribution of human papillomavirus type 58 variants in progression of cervical dysplasia in Korean women.
This cross-sectional study examined the distribution of HPV 58 sequence variation in Korean women for the first time. Among 1,750 Korean women, 53 women were positive for HPV 58 single infection, of whom 26 were without disease, 20 were with cervical intraepithelial neoplasia (CIN) 1, and 7 with CIN 2 or 3. Altogether, 36 different nucleotide sequence variations were identified with the L1, 20 within E2, 5 within E6, and 10 within E7. Further studies on variants of oncogenic HPVs are necessary, particularly for the purpose of developing more predictive HPV detection methods.
Bae
Jeong-Hoon
JH
Department of Obstetrics and Gynecology, The Catholic University of Korea, Seoul, Korea.
Cheung
Jo L K
JL
Lee
Sung-Jong
SJ
Luk
Alfred C S
AC
Tong
Seo-Yun
SY
Chan
Paul K S
PK
Park
Jong-Sup
JS
D052685:Alphapapillomavirus / Q000235:genetics* / Q000302:isolation & purification; D018450:Disease Progression; D005260:Female; D005814:Genes, Viral / Q000235:genetics; D014644:Genetic Variation; D006801:Humans; D007723:Korea; D030361:Papillomavirus Infections / Q000453:epidemiology*; D020641:Polymorphism, Single Nucleotide; D002578:Uterine Cervical Dysplasia / Q000150:complications / Q000821:virology*; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology / Q000235:genetics / Q000821:virology