Chylomicronemia elicits atherosclerosis in mice--brief report.
OBJECTIVE
The risk of atherosclerosis in the setting of chylomicronemia has been a topic of debate. In this study, we examined susceptibility to atherosclerosis in Gpihbp1-deficient mice (Gpihbp1(-/-)), which manifest severe chylomicronemia as a result of defective lipolysis.


RESULTS
Gpihbp1(-/-) mice on a chow diet have plasma triglyceride and cholesterol levels of 2812+/-209 and 319+/-27 mg/dL, respectively. Even though nearly all of the lipids were contained in large lipoproteins (50 to 135 nm), the mice developed progressive aortic atherosclerosis. In other experiments, we found that both Gpihbp1-deficient "apo-B48-only" mice and Gpihbp1-deficient "apo-B100-only" mice manifest severe chylomicronemia. Thus, GPIHBP1 is required for the processing of both apo-B48- and apo-B100-containing lipoproteins.


CONCLUSIONS
Chylomicronemia causes atherosclerosis in mice. Also, we found that GPIHBP1 is required for the lipolytic processing of both apo-B48- and apo-B100-containing lipoproteins.
Weinstein
Michael M
MM
Departments of Medicine, University of California, Los Angeles, USA.
Yin
Liya
L
Tu
Yiping
Y
Wang
Xuping
X
Wu
Xiaohui
X
Castellani
Lawrence W
LW
Walzem
Rosemary L
RL
Lusis
Aldons J
AJ
Fong
Loren G
LG
Beigneux
Anne P
AP
Young
Stephen G
SG
D000821:Animal Feed; D000818:Animals; D001018:Aortic Diseases / Q000453:epidemiology / Q000235:genetics / Q000378:metabolism; D053299:Apolipoprotein B-100 / Q000378:metabolism*; D053283:Apolipoprotein B-48 / Q000378:metabolism*; D050197:Atherosclerosis / Q000453:epidemiology / Q000235:genetics / Q000378:metabolism*; D002914:Chylomicrons / Q000378:metabolism*; D005227:Fatty Acids / Q000378:metabolism; D005260:Female; D020022:Genetic Predisposition to Disease; D008066:Lipolysis / Q000502:physiology; D008297:Male; D051379:Mice; D008817:Mice, Mutant Strains; D018110:Receptors, Lipoprotein / Q000235:genetics / Q000378:metabolism*; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
D053299:Apolipoprotein B-100; D053283:Apolipoprotein B-48; D002914:Chylomicrons; D005227:Fatty Acids; C472779:GPI-HBP1 protein, mouse; D018110:Receptors, Lipoprotein; D014280:Triglycerides