Effects of soy isoflavones on the uterus and urethra of ovariectomized rats.
OBJECTIVE
To evaluate the effect of soy isoflavone extract (SIE) on the uterus and urethra of castrated female rats.


METHODS
Ovariectomized adult virgin Wistar rats (n = 45) received, for 30 days: placebo (GI); SIE from day 5 of castration (GII); or day 28 of castration (GIII). A standardized SIE was administered by gavage at 125 microg genistein/g body weight/day, with a soy-free diet. Average numbers of nuclei (NU), blood vessels (BV) and collagen fibers (CF) in uterus and mid-urethra sections were compared using Dunnett and Tukey tests (95% CI).


RESULTS
Uterus: GII and GIII differed from GI in all respects; GII vs. GIII, no differences. Urethra: GIII vs. GI: no differences; GII vs. GI, differences in NU and CF; GII vs. GIII, differences in NU and CF.


CONCLUSIONS
Early oral administration of SIE to ovariectomized rats reversed uterine/urethral effects of castration.
Santos
Elaine Travaglia
ET
Department of Gynecology, Federal University of São Paulo, São Paulo, Brazil. etravaglia@uol.com.br
Sampaio
Maria Dione Dutra
MD
Cecon
Paulo Roberto
PR
Simões
Manuel de Jesus
Mde J
Sartori
Marair Gracio Ferreira
MG
Girão
Manoel João Batista Castello
MJ
D000284:Administration, Oral; D000818:Animals; D001808:Blood Vessels / Q000166:cytology / Q000187:drug effects; D002467:Cell Nucleus / Q000187:drug effects; D003094:Collagen / Q000187:drug effects; D005260:Female; D007529:Isoflavones / Q000008:administration & dosage / Q000494:pharmacology*; D023421:Models, Animal; D009130:Muscle, Smooth / Q000166:cytology / Q000187:drug effects; D010052:Ovariectomy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013025:Glycine max; D013997:Time Factors; D014521:Urethra / Q000166:cytology / Q000187:drug effects*; D014599:Uterus / Q000166:cytology / Q000187:drug effects*
D007529:Isoflavones; D010936:Plant Extracts; D003094:Collagen