title: Chromatin and nuclear organization in Trypanosoma cruzi.
abstract: A total of 100 years have passed since the discovery of the protozoan Trypanosoma cruzi, the etiologic agent of Chagas' disease. Since its discovery, the molecular and cellular biology of this early divergent eukaryote, as well as its interactions with the mammalian and insect hosts, has progressed substantially. It is now clear that this parasite presents unique mechanisms controlling gene expression, DNA replication, cell cycle and differentiation, generating several morphological forms that are adapted to survive in different hosts. In recent years, the relationship between the chromatin structure and nuclear organization with the unusual transcription, splicing, DNA replication and DNA repair mechanisms have been investigated in T. cruzi. This article reviews the relevant aspects of these mechanisms in relation to chromatin and nuclear organization.
authors.affiliation: Laboratório de Parasitologia, Instituto Butantan, São Paulo, Brazil. carol@butantan.gov.br
authors.forename: Maria Carolina
authors.initials: MC
authors.lastname: Elias
authors.forename: Sheila Cristina
authors.initials: SC
authors.lastname: Nardelli
authors.forename: Sergio
authors.initials: S
authors.lastname: Schenkman
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D014355:Chagas Disease / Q000469:parasitology; D002843:Chromatin / Q000235:genetics / Q000378:metabolism*; D004260:DNA Repair; D004261:DNA Replication; D005786:Gene Expression Regulation; D006790:Host-Parasite Interactions; D006801:Humans; D015800:Protozoan Proteins / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic; D014349:Trypanosoma cruzi / Q000235:genetics / Q000254:growth & development / Q000378:metabolism / Q000472:pathogenicity
chemical_list: D002843:Chromatin; D015800:Protozoan Proteins