title: Serum glutamic-oxaloacetic transaminase (GOT) and glutamic-pyruvic transaminase (GPT) levels in children and adolescents with intellectual disabilities.
abstract: The elevated serum glutamic-oxaloacetic transaminase (GOT) and glutamic-pyruvic transaminase (GPT) rate among people with intellectual disabilities (ID) is unknown and have not been sufficiently studies. The present paper aims to provide the profile of GOT and GPT, and their associated relationship with other biochemical levels of children or adolescents with ID. A cross-sectional design was conducted in three Taiwanese public special schools to analyze annual health examination chart of students with ID. There were 1041 aged 3-21 years children and adolescents with ID participated in the study. The results show elevated rate of GOT and GPT were 3.7% and 7.2%, the study indicates the elevated GPT in children and adolescents with ID is higher than the general school aged children in Taiwan. In multiple linear regression models show that the factors of BMI, HBsAg, TC and UA can significantly explain the GOT value (R(2)=0.275). Those factors of gender, BMI, HBsAg, TC and UA can significantly explain 44.4% variation of GPT value (R(2)=0.444). To prevent the further liver disease burden in people with ID, the study highlights that the health care professionals should assess liver functions of this group of people, and to inform their caregivers the importance of implement regular liver health check-up.
authors.affiliation: School of Public Health, National Defense Medical Center, Taipei, Taiwan. a530706@ndmctsgh.edu.tw
authors.forename: Jin-Ding
authors.initials: JD
authors.lastname: Lin
authors.forename: Pei-Ying
authors.initials: PY
authors.lastname: Lin
authors.forename: Li-Mei
authors.initials: LM
authors.lastname: Chen
authors.forename: Wen-Hui
authors.initials: WH
authors.lastname: Fang
authors.forename: Lan-Ping
authors.initials: LP
authors.lastname: Lin
authors.forename: Ching-Hui
authors.initials: CH
authors.lastname: Loh
mesh_terms: D000293:Adolescent; D000410:Alanine Transaminase / Q000097:blood*; D001219:Aspartate Aminotransferases / Q000097:blood*; D015992:Body Mass Index; D002648:Child; D002675:Child, Preschool; D002784:Cholesterol / Q000097:blood; D003430:Cross-Sectional Studies; D004495:Education of Persons with Intellectual Disabilities; D005260:Female; D006514:Hepatitis B Surface Antigens / Q000097:blood; D018937:Hepatitis C Antibodies / Q000097:blood; D006801:Humans; D008607:Intellectual Disability / Q000201:enzymology*; D007564:Japan; D008107:Liver Diseases / Q000175:diagnosis* / Q000201:enzymology*; D008111:Liver Function Tests; D008297:Male; D008403:Mass Screening; D012016:Reference Values; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
chemical_list: D006514:Hepatitis B Surface Antigens; D018937:Hepatitis C Antibodies; D014280:Triglycerides; D002784:Cholesterol; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase