Bioorganic synthesis of end-capped anti-HIV peptides by simultaneous cyanocysteine-mediated cleavages of recombinant proteins.
Bioorganic synthesis of N- and C-terminal end-capped peptides by two simultaneous S-cyanocysteine-mediated cleavages of recombinant proteins is described. This approach is demonstrated in the preparation of anti-HIV fusion inhibitory peptides.
Tanaka
Michinori
M
Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan.
Kajiwara
Kazumi
K
Tokiwa
Rei
R
Watanabe
Kentaro
K
Ohno
Hiroaki
H
Tsutsumi
Hiroko
H
Hata
Yoji
Y
Izumi
Kazuki
K
Kodama
Eiichi
E
Matsuoka
Masao
M
Oishi
Shinya
S
Fujii
Nobutaka
N
D000595:Amino Acid Sequence; D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D003545:Cysteine / Q000737:chemistry*; D023581:HIV Fusion Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D008969:Molecular Sequence Data; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011993:Recombinant Fusion Proteins / Q000378:metabolism*
D019380:Anti-HIV Agents; D023581:HIV Fusion Inhibitors; D010455:Peptides; D011993:Recombinant Fusion Proteins; D003545:Cysteine