Molecular mechanisms of viral immune evasion proteins to inhibit MHC class I antigen processing and presentation.
Viral products inhibit MHC class I antigen processing and presentation via three major pathways: inhibition of major histocompatibility complex (MHC) class I expression on cells, blockade of peptide trafficking and loading on MHC class I molecules, and inhibition of peptide generation in host cells. Viral products also interfere with IFN-gamma -mediated JAK/STAT signal transduction in cells. These results imply that viral proteins probably inhibit the function of IFN-gamma in MHC class I antigen presentation via inactivation of JAK/STAT signal transduction in host cells. Mechanisms of viral products to inhibit IFN-gamma -mediated MHC class I antigen presentation were summarized in this literature review.
Zhou
Fang
F
University of Queensland Diamantina Institute for Cancer Immunology and Metabolic Medicine, Princess Alexandra Hospital, Brisbane QLD 4102, Australia. f.zhou@uq.edu.au
D000818:Animals; D017951:Antigen Presentation / Q000276:immunology*; D015395:Histocompatibility Antigens Class I / Q000276:immunology*; D006801:Humans; D057131:Immune Evasion / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology*; D014764:Viral Proteins / Q000276:immunology*
D015395:Histocompatibility Antigens Class I; D014764:Viral Proteins