Circadian rhythms and chemical carcinogenesis: Potential link. An overview.
Circadian rhythm is an integral and not replaceable part of the organism's homeostasis. Its signalling is multidimensional, overlooking global networks such as chromatin remodelling, cell cycle, DNA damage and repair as well as nuclear receptors function. Understanding its global networking will allow us to follow up not only organism dysfunction and pathology (including chemical carcinogenesis) but well-being in general having in mind that time is not always on our side.
Oesch-Bartlomowicz
Barbara
B
ECNIS Unit, University of Mainz, D-55131 Mainz, Germany. oeschb@uni-mainz.de
Weiss
Carsten
C
Dietrich
Cornelia
C
Oesch
Franz
F
D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D002453:Cell Cycle / Q000502:physiology; D018797:Cell Cycle Proteins / Q000502:physiology; D002940:Circadian Rhythm / Q000187:drug effects* / Q000502:physiology; D004247:DNA / Q000187:drug effects; D004249:DNA Damage; D004260:DNA Repair; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D009369:Neoplasms / Q000209:etiology* / Q000503:physiopathology; D056950:Period Circadian Proteins / Q000378:metabolism
D002273:Carcinogens; D018797:Cell Cycle Proteins; D056950:Period Circadian Proteins; D004247:DNA