title: Treatment with DNAse I fosters binding to nec PBMC of CRP.
abstract: CRP is an important inflammatory marker, however, CRP levels are relatively low in patients with SLE. In addition patients with SLE often display low activities and serum levels for DNase I and complement, respectively. Here we show that DNase I treatment of nec PBMC increased their binding of CRP. Consequently, reduced DNase I activity in patients with SLE may contribute to the impaired opsonisation by CRP of dead cells, exacerbating the clearance defect in SLE of apo and nec cells.
authors.affiliation: Department for Internal Medicine 3, Institute for Clinical Immunology, Friedrich-Alexander University of Erlangen-Nürnberg, Erlangen, Germany. christina.janko@uk-erlangen.de
authors.forename: Christina
authors.initials: C
authors.lastname: Janko
authors.forename: Christine
authors.initials: C
authors.lastname: Schorn
authors.forename: Daniela
authors.initials: D
authors.lastname: Weidner
authors.forename: Kerstin
authors.initials: K
authors.lastname: Sarter
authors.forename: Ricardo
authors.initials: R
authors.lastname: Chaurio
authors.forename: Ahmed
authors.initials: A
authors.lastname: Sheriff
authors.forename: Georg
authors.initials: G
authors.lastname: Schett
authors.forename: Luis E
authors.initials: LE
authors.lastname: Munoz
mesh_terms: D002097:C-Reactive Protein / Q000378:metabolism*; D002478:Cells, Cultured; D003850:Deoxyribonuclease I / Q000276:immunology / Q000378:metabolism*; D005434:Flow Cytometry; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000276:immunology / Q000378:metabolism* / Q000473:pathology*; D009336:Necrosis; D010587:Phagocytosis / Q000276:immunology
chemical_list: D002097:C-Reactive Protein; D003850:Deoxyribonuclease I