Serum selenium and prognosis in cardiovascular disease: results from the AtheroGene study.
OBJECTIVE
Experimental data suggest a protective role of the essential trace element selenium against cardiovascular disease (CVD), whereas epidemiological data remains controversial. We aimed to investigate the impact of serum selenium concentration in patients presenting with stable angina pectoris (SAP) or acute coronary syndrome (ACS) on long term prognosis.


METHODS
Baseline selenium concentration was measured in 1731 individuals (852 with SAP, and 879 with ACS). During a median follow-up of 6.1 years, 190 individuals died from cardiovascular causes.


RESULTS
In those ACS patients who subsequently died of cardiac causes, selenium levels were lower compared to survivors (61.0microg/L versus 71.5microg/L; P<0.0001). In a fully adjusted model, patients in the highest tertile of selenium concentration had a hazard ratio of 0.38 (95% CI: 0.16-0.91; P=0.03) as compared with those in the lowest. No association between selenium levels and cardiovascular outcome was observed in SAP.


CONCLUSIONS
Low selenium concentration was associated with future cardiovascular death in patients with ACS.
Lubos
Edith
E
Department of Medicine II, Johannes Gutenberg-University Mainz, Langenbeckstr. 1, Mainz, Germany.
Sinning
Christoph R
CR
Schnabel
Renate B
RB
Wild
Philipp S
PS
Zeller
Tanja
T
Rupprecht
Hans J
HJ
Bickel
Christoph
C
Lackner
Karl J
KJ
Peetz
Dirk
D
Loscalzo
Joseph
J
Münzel
Thomas
T
Blankenberg
Stefan
S
D054058:Acute Coronary Syndrome / Q000097:blood / Q000401:mortality*; D000368:Aged; D000787:Angina Pectoris / Q000097:blood / Q000401:mortality*; D050197:Atherosclerosis / Q000097:blood / Q000401:mortality*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D012643:Selenium / Q000097:blood*; D015996:Survival Rate
D012643:Selenium