Tuning down NF-kappaB signaling by DUBs: a fly case.
The Drosophila immune deficiency (IMD) signaling cascade regulates the IKK/NF-kappaB signaling cassette and shares striking similarities with the mammalian TNF-R1 pathway. Thevenon et al. (2009) reveal how dUSP36, a deubiquitinating enzyme of the ubiquitin-specific protease (USP) family, prevents the constitutive activation of the IMD pathway by resident gut bacteria.
Leulier
François
F
Institut de Biologie du Développement de Marseille-Luminy (IBDML), UMR 6216 CNRS, Université de la Méditérannée Aix-Marseille II, Parc Scientifique de Luminy-Case 907, 13288 Marseille Cedex 9, France. francois.leulier@ibdml.univ-mrs.fr
D000818:Animals; D001419:Bacteria / Q000276:immunology*; D004330:Drosophila / Q000276:immunology*; D029721:Drosophila Proteins / Q000276:immunology*; D010450:Endopeptidases / Q000276:immunology*; D041981:Gastrointestinal Tract / Q000382:microbiology*; D007155:Immunologic Factors / Q000276:immunology*; D008954:Models, Biological; D016328:NF-kappa B / Q000037:antagonists & inhibitors* / Q000276:immunology*
D029721:Drosophila Proteins; D007155:Immunologic Factors; D016328:NF-kappa B; D010450:Endopeptidases; C534688:ubiquitin specific protease 36, Drosophila