title: Evaluation of oxidant-antioxidant balance in patients on maintenance haemodialysis: a comparative study of dialyzers membranes.
abstract: BACKGROUND
  Haemodialysis (HD) exacerbates oxidative stress (OS). The polymethyl-methacrylate (PMMA)-BK-F membrane ameliorates OS and inflammation markers compared to polyacrylonitrile (PAN/AN69) and cellulose membranes. This may be due to the size of pore radius, high flux or other specific properties of PMMA membranes.
  
  
  OBJECTIVE
  To compare OS and inflammatory status in HD-treated end stage renal disease patients with membranes of different pore size radius and flux.
  
  
  METHODS
  47 patients of both sexes were studied. The HD membranes with which the patients were normally treated were changed to BK-P or B-3 membranes for 6 months. Intracellular and extracellular components of the oxidant-antioxidant balance (OAB), C-reactive protein (CRP), beta2-micro-globulin (beta2mu-globulin), albumin and transferrin were measured.
  
  
  RESULTS
  A significant decrease in red cell membrane thiobarbituric acid reacting substances and an increase in cytosolic superoxide dismutase (SOD) and plasma total antioxidant substances were observed in all patients after 6 months of treatment with BK-P and B-3 membranes except SOD and CRP in patients previously dialysed with triacetate cellulose membranes. Albumin and transferrin remained unmodified. beta2mu-globulin significantly decreased after treatment with PMMA membranes.
  
  
  CONCLUSIONS
  BK-P and B-3 HD membranes improved the OAB, beta2mu-globulin and CRP compared to PAN/AN69 and cellulose diacetate membranes.
authors.affiliation: Hospital Clínico Universitario, Salamanca, Spain. jfmacias@usal.es
authors.forename: Juan F
authors.initials: JF
authors.lastname: Macías Núñez
authors.forename: Zoubiair
authors.initials: Z
authors.lastname: Ghais
authors.forename: Jesus
authors.initials: J
authors.lastname: Bustamante
authors.forename: Jose M
authors.initials: JM
authors.lastname: Lopez-Novoa
authors.forename: J
authors.initials: J
authors.lastname: Arrieta
authors.forename: G
authors.initials: G
authors.lastname: Barril
authors.forename: María D
authors.initials: MD
authors.lastname: Del Pino
authors.forename: C
authors.initials: C
authors.lastname: Escaja
authors.forename: I M
authors.initials: IM
authors.lastname: Martín
authors.forename: C
authors.initials: C
authors.lastname: Fernández Andrade
authors.forename: F
authors.initials: F
authors.lastname: García
authors.forename: J
authors.initials: J
authors.lastname: Núñez
authors.forename: J M
authors.initials: JM
authors.lastname: Onaindía
authors.forename: J
authors.initials: J
authors.lastname: González
authors.forename: M
authors.initials: M
authors.lastname: Pérez-Prieto
authors.forename: M
authors.initials: M
authors.lastname: Fernández
authors.forename: J
authors.initials: J
authors.lastname: Lopez
authors.forename: J M
authors.initials: JM
authors.lastname: Santiago
authors.forename: M
authors.initials: M
authors.lastname: Vicens
authors.forename: F
authors.initials: F
authors.lastname: Sousa
mesh_terms: D000328:Adult; D000368:Aged; D002097:C-Reactive Protein / Q000032:analysis; D015897:Comorbidity; D004867:Equipment Design; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000453:epidemiology / Q000378:metabolism* / Q000628:therapy; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology; D006435:Renal Dialysis; D012709:Serum Albumin / Q000032:analysis; D013482:Superoxide Dismutase / Q000378:metabolism; D014168:Transferrin / Q000032:analysis; D001613:beta 2-Microglobulin / Q000097:blood
chemical_list: D008567:Membranes, Artificial; D012709:Serum Albumin; D014168:Transferrin; D001613:beta 2-Microglobulin; D002097:C-Reactive Protein; D013482:Superoxide Dismutase