Comment on "The Arabidopsis circadian clock incorporates a cADPR-based feedback loop".
Dodd et al. (Reports, 14 December 2007, p. 1789) reported that the Arabidopsis circadian clock incorporates the signaling molecule cyclic adenosine diphosphate ribose (cADPR). In contrast, we found that there is no rhythm of cADPR levels nor are there any significant effects on the rhythm by cADPR overexpression, thus raising questions about the conclusions of Dodd et al.
Xu
Xiaodong
X
Department of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA.
Graeff
Richard
R
Xie
Qiguang
Q
Gamble
Karen L
KL
Mori
Tetsuya
T
Johnson
Carl Hirschie
CH
D036541:ADP-ribosyl Cyclase / Q000378:metabolism; D017360:Arabidopsis / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D002118:Calcium / Q000378:metabolism*; D002940:Circadian Rhythm; D036563:Cyclic ADP-Ribose / Q000378:metabolism*; D004958:Estradiol / Q000494:pharmacology; D025461:Feedback, Physiological; D009536:Niacinamide / Q000494:pharmacology
D036563:Cyclic ADP-Ribose; D009536:Niacinamide; D004958:Estradiol; D036541:ADP-ribosyl Cyclase; D002118:Calcium