title: Increased umbilical cord plasma interleukin-1 beta levels was correlated with adverse outcomes of neonatal hypoxic-ischemic encephalopathy.
abstract: To explore whether or not the umbilical blood levels of cytokines can be used to indicate the adverse outcomes of hypoxic-ischemic encephalopathy (HIE) patients. Umbilical artery blood and peripheral venous blood samples were collected on the 1st, 3rd and 7th days after birth to detect the levels of IL-1 beta, IL-8 and TNF-alpha. Neurological examination and Denver developmental screening test (DDST-II) were performed at the 6 and 12 months evaluations to detect any neurodevelopmental abnormalities. The results showed: (i) the serum concentrations of IL-1 beta, IL-8 and TNF-alpha in umbilical and peripheral blood were significantly higher in HIE patients than control groups; (ii) the umbilical blood concentrations of IL-1 beta exhibited the best positive correlation with HIE grades, when compared with IL-8 and TNF-alpha; and (iii) abnormal neurological outcomes at 6 and 12 months of age were best predicted by umbilical levels of IL-1 beta. Thus, umbilical concentrations of IL-1 beta were associated with the grades and adverse outcomes of HIE.
authors.affiliation: Department of Neonatology and NICU Feng, Bayi Children's Hospital Affiliated with Beijing Military Region General Hospital, Beijing 100700, China. liujingbj@live.cn
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
authors.forename: Zhi-Chun
authors.initials: ZC
authors.lastname: Feng
mesh_terms: D000328:Adult; D001238:Asphyxia Neonatorum / Q000209:etiology; D016022:Case-Control Studies; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology*; D007231:Infant, Newborn; D053583:Interleukin-1beta / Q000097:blood / Q000134:cerebrospinal fluid*; D016209:Interleukin-8 / Q000097:blood / Q000134:cerebrospinal fluid*; D008297:Male; D009460:Neurologic Examination; D011247:Pregnancy; D012016:Reference Values; D012720:Severity of Illness Index; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000134:cerebrospinal fluid*; D014470:Umbilical Cord / Q000378:metabolism
chemical_list: D053583:Interleukin-1beta; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha