title: Is short-term palliative care cost-effective in multiple sclerosis? A randomized phase II trial.
abstract: BACKGROUND
  Palliative care is being advocated for noncancer patients but needs evidence of effectiveness and cost-effectiveness.
  
  
  OBJECTIVE
  We evaluated the cost-effectiveness of a new palliative care service for people with multiple sclerosis (MS).
  
  
  METHODS
  We used a randomized fast-track Phase II controlled trial. Patients in South East London who were severely affected by MS were referred by clinicians to the trial. After baseline interview, patients were randomly allocated to either a multiprofessional palliative care team (PCT) immediately (fast track) or the control care group who continued best usual care for three months and then were offered the PCT. Data were collected at baseline, 6, 12, 18, and 26 weeks on use of services, patient symptoms, other outcomes, and caregiver burden.
  
  
  RESULTS
  Fifty-two patients were randomized: 25 fast track and 21 control patients completed the trial. There was a high level of disability, and mean Expanded Disability Status Scale score was 7.7 (median 8, standard deviation 1.0). At 12 weeks, caregiver burden was 4.47 points lower (95% confidence interval [CI]: 1.05-7.89) in the fast track compared to the control group. Mean service costs, including inpatient care and informal care, over the 0-12-week follow-up were pound1,789 lower for the fast-track group (bootstrapped 95% CI: - pound5,224 to pound1,902). There was a trend toward lower community costs in the fast-track group and no differences in costs to informal caregivers.
  
  
  CONCLUSIONS
  The trial suggests that short-term palliative care for people severely affected by MS and their caregivers will be cost-effective and warrants further study. The fast-track trial design could be used to assess this.
authors.affiliation: Department of Palliative Care, Policy and Rehabilitation, King's College London, London SE5 9RJ, United Kingdom.
authors.forename: Irene J
authors.initials: IJ
authors.lastname: Higginson
authors.forename: Paul
authors.initials: P
authors.lastname: McCrone
authors.forename: Sam R
authors.initials: SR
authors.lastname: Hart
authors.forename: Rachel
authors.initials: R
authors.lastname: Burman
authors.forename: Eli
authors.initials: E
authors.lastname: Silber
authors.forename: Polly M
authors.initials: PM
authors.lastname: Edmonds
mesh_terms: D000328:Adult; D003362:Cost-Benefit Analysis; D003625:Data Collection; D005260:Female; D005500:Follow-Up Studies; D006296:Health Services / Q000191:economics / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000628:therapy*; D010166:Palliative Care / Q000191:economics*; D016896:Treatment Outcome