Revisiting clinical trials on glycemic control and cardiovascular risk.
The most relevant clinical trials, assessing the role of glycemic control in reducing cardiovascular risk, are examined. The UKPDS was the first to address this issue. More recent trials (ACCORD, ADVANCE and VADT) are controversial and evidences did not support that strict glycemic control (reflected by normal glycated hemoglobin) exclusively is sufficient to reduce cardiovascular risk in complicated individuals with long-term type 2 diabetes mellitus. Some possible reasons for controversies are included.
Ferreira
Sandra Roberta Gouvea
SR
Nutrition Department, School of Public Health, University of São Paulo, Brazil. sandrafv@usp.br.