Glucose transporters in gametes and preimplantation embryos.
The oocyte, sperm and preimplantation embryo have unique metabolic needs that must be met to ensure successful pregnancy. The family of facilitative glucose transporters (GLUTs) plays a major role in providing metabolic substrates to these tissues. The variety of GLUTs expressed in these tissues allows for flexibility to adapt to a changing environment. Alterations in glucose transport and metabolism at the earliest stages of development can impact fetal development. Research into the mechanisms of normal glucose transport into cells is critical for improving outcomes in the increasingly common diabetic maternal environment. Here, we review the current understanding in the distribution and role of glucose transporters in gametes and preimplantation embryos under normal and diabetic conditions.
Purcell
Scott H
SH
Department of Obstetrics and Gynecology, Washington University in St. Louis, St. Louis, MO, USA.
Moley
Kelle H
KH
D000818:Animals; D005260:Female; D005854:Germ Cells / Q000378:metabolism*; D051246:Glucose Transport Proteins, Facilitative / Q000378:metabolism*; D006801:Humans; D008297:Male; D009865:Oocytes / Q000378:metabolism; D011247:Pregnancy; D013094:Spermatozoa / Q000378:metabolism
D051246:Glucose Transport Proteins, Facilitative