Risk factors for incident mild cognitive impairment--results from the German Study on Ageing, Cognition and Dementia in Primary Care Patients (AgeCoDe).
OBJECTIVE
To provide age- and gender-specific incidence rates of MCI among elderly general practitioner (GP) patients (75+ years) and to identify risk factors for incident MCI.


METHODS
Data were derived from the longitudinal German Study on Ageing, Cognition and Dementia in Primary Care Patients (AgeCoDe). Incidence was calculated according to the 'person-years-at-risk' method. Risk factors were analysed using multivariate logistic regression models.


RESULTS
During the 3-year follow-up period, 350 (15.0%) of the 2331 patients whose data were included in the calculation of incidence developed MCI [person-years (PY) = 6198.20]. The overall incidence of MCI was 56.5 (95% confidence interval = 50.7-62.7) per 1000 PY. Older age, vascular diseases, the apoE epsilon4 allele and subjective memory complaints were identified as significant risk factors for future MCI.


CONCLUSIONS
Mild cognitive impairment is frequent in older GP patients. Subjective memory complaints predict incident MCI. Especially vascular risk factors provide the opportunity of preventive approaches.
Luck
T
T
Public Health Research Unit, Department of Psychiatry, University of Leipzig, Leipzig, Germany. tobias.luck@medizin.uni-leipzig.de
Riedel-Heller
S G
SG
Luppa
M
M
Wiese
B
B
Wollny
A
A
Wagner
M
M
Bickel
H
H
Weyerer
S
S
Pentzek
M
M
Haller
F
F
Moesch
E
E
Werle
J
J
Eisele
M
M
Maier
W
W
van den Bussche
H
H
Kaduszkiewicz
H
H
D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D053327:Apolipoprotein E4 / Q000235:genetics*; D003071:Cognition; D003072:Cognition Disorders / Q000453:epidemiology* / Q000209:etiology* / Q000235:genetics / Q000517:prevention & control; D003704:Dementia / Q000150:complications / Q000453:epidemiology*; D005194:Family Practice; D005260:Female; D005858:Germany; D006801:Humans; D015994:Incidence; D008137:Longitudinal Studies; D008297:Male; D008569:Memory Disorders / Q000150:complications / Q000453:epidemiology*; D012307:Risk Factors; D012737:Sex Factors; D014652:Vascular Diseases / Q000150:complications / Q000453:epidemiology*
D053327:Apolipoprotein E4