[Cardioprotective action of coenzyme Q in conditions of its endogenous synthesis activation in cardiac ischemia-reperfusion in old rats].
The changes of functional state isolated by Lanhendorf old rat hearts with low content of ubiqinone--coenzyme Q (CoQ) under activation of it endogenous synthesis through administration of precursors--4-hydroxybenzoic acid, methionine and modulator vitamin E were studied. The activation of ubiqinone biosynthesis contribute to cardioprotective effect due to reduce the degree of the ischemia-reperfusion injury in old rat heart, namely the restoration of myocardial contractile function and coronary flow as well as decrease the end diastolic pressure and oxygen cost of the heart compared with control group of the animals during ischemia-reperfusion. Thus the results allow to conclude that the activation of KoQ biosynthesis under administration of it precursors has protective effect in the development of the heart postreperfusion damages in aging.
Timoshchuk
S V
SV
Vavilova
H L
HL
Strutyns'ka
N A
NA
Talanov
S A
SA
Petukhov
D M
DM
Kuchmenko
O B
OB
Donchenko
H V
HV
Sahach
V F
VF
D000375:Aging / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D002316:Cardiotonic Agents / Q000494:pharmacology; D003326:Coronary Circulation / Q000187:drug effects; D006321:Heart / Q000187:drug effects; D006334:Heart Function Tests; D066298:In Vitro Techniques; D008297:Male; D008715:Methionine / Q000494:pharmacology; D015425:Myocardial Reperfusion; D015428:Myocardial Reperfusion Injury / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D010226:Parabens / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D014451:Ubiquinone / Q000096:biosynthesis* / Q000502:physiology; D024502:alpha-Tocopherol / Q000494:pharmacology
D002316:Cardiotonic Agents; D010226:Parabens; D014451:Ubiquinone; D008715:Methionine; D024502:alpha-Tocopherol; C038193:4-hydroxybenzoic acid