title: Effects of soy isoflavones on the uterus and urethra of ovariectomized rats.
abstract: OBJECTIVE
  To evaluate the effect of soy isoflavone extract (SIE) on the uterus and urethra of castrated female rats.
  
  
  METHODS
  Ovariectomized adult virgin Wistar rats (n = 45) received, for 30 days: placebo (GI); SIE from day 5 of castration (GII); or day 28 of castration (GIII). A standardized SIE was administered by gavage at 125 microg genistein/g body weight/day, with a soy-free diet. Average numbers of nuclei (NU), blood vessels (BV) and collagen fibers (CF) in uterus and mid-urethra sections were compared using Dunnett and Tukey tests (95% CI).
  
  
  RESULTS
  Uterus: GII and GIII differed from GI in all respects; GII vs. GIII, no differences. Urethra: GIII vs. GI: no differences; GII vs. GI, differences in NU and CF; GII vs. GIII, differences in NU and CF.
  
  
  CONCLUSIONS
  Early oral administration of SIE to ovariectomized rats reversed uterine/urethral effects of castration.
authors.affiliation: Department of Gynecology, Federal University of São Paulo, São Paulo, Brazil. etravaglia@uol.com.br
authors.forename: Elaine Travaglia
authors.initials: ET
authors.lastname: Santos
authors.forename: Maria Dione Dutra
authors.initials: MD
authors.lastname: Sampaio
authors.forename: Paulo Roberto
authors.initials: PR
authors.lastname: Cecon
authors.forename: Manuel de Jesus
authors.initials: Mde J
authors.lastname: Simões
authors.forename: Marair Gracio Ferreira
authors.initials: MG
authors.lastname: Sartori
authors.forename: Manoel João Batista Castello
authors.initials: MJ
authors.lastname: Girão
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001808:Blood Vessels / Q000166:cytology / Q000187:drug effects; D002467:Cell Nucleus / Q000187:drug effects; D003094:Collagen / Q000187:drug effects; D005260:Female; D007529:Isoflavones / Q000008:administration & dosage / Q000494:pharmacology*; D023421:Models, Animal; D009130:Muscle, Smooth / Q000166:cytology / Q000187:drug effects; D010052:Ovariectomy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013025:Glycine max; D013997:Time Factors; D014521:Urethra / Q000166:cytology / Q000187:drug effects*; D014599:Uterus / Q000166:cytology / Q000187:drug effects*
chemical_list: D007529:Isoflavones; D010936:Plant Extracts; D003094:Collagen