title: Platelet aggregation in intracranial stents may mimic in-stent restenosis.
abstract: We report the case of an early ISR that was due to platelet aggregation despite correct observance of a standard antiplatelet regimen. Biologic testing showed clopidogrel inefficiency, and ISR disappeared on angiography after a loading dose of clopidogrel. This result suggested that the arterial lumen reduction was due to platelet aggregation rather than in-stent myointimal hyperplasia. This observation emphasizes the importance of verifying the efficacy of clopidogrel before placing a stent.
authors.affiliation: Service de Neuroradiologie Diagnostique et Interventionnelle, Hopital Lariboisiere, Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Mazighi
authors.forename: J P
authors.initials: JP
authors.lastname: Saint Maurice
authors.forename: D
authors.initials: D
authors.lastname: Bresson
authors.forename: Z
authors.initials: Z
authors.lastname: Szatmary
authors.forename: E
authors.initials: E
authors.lastname: Houdart
mesh_terms: D002533:Cerebral Angiography; D000077144:Clopidogrel; D003937:Diagnosis, Differential; D004351:Drug Resistance; D006083:Graft Occlusion, Vascular / Q000000981:diagnostic imaging* / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D015607:Stents / Q000009:adverse effects*; D013988:Ticlopidine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D017211:Treatment Failure
chemical_list: D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D013988:Ticlopidine