Epoxyphomalin A and B, prenylated polyketides with potent cytotoxicity from the marine-derived fungus Phoma sp.
Chemical investigation of a strain of the marine-derived fungus Phoma sp. has led to the discovery of epoxyphomalin A (1) and B (2), two new prenylated polyketides with unusual structural features. Epoxyphomalin A (1) showed superior cytotoxicity at nanomolar concentrations toward 12 of a panel of 36 human tumor cell lines. In COMPARE analyses, the observed cytotoxic selectivity pattern of 1 did not correlate with those of reference anticancer agents with known mechanisms of action.
Mohamed
Ietidal E
IE
Department of Botany, University of Khartoum, Khartoum, Sudan.
Gross
Harald
H
Pontius
Alexander
A
Kehraus
Stefan
S
Krick
Anja
A
Kelter
Gerhard
G
Maier
Armin
A
Fiebig
Heinz-Herbert
HH
König
Gabriele M
GM
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001203:Ascomycota / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D008386:Marine Biology; D011161:Porifera / Q000382:microbiology
D000970:Antineoplastic Agents; D018942:Macrolides; C545922:epoxyphomalin A; C545923:epoxyphomalin B