title: The role of fentanyl in cancer-related pain.
abstract: Fentanyl is a lipophilic, short-acting, synthetic opioid with a piperidine chemical structure. Fentanyl is an effective analgesic for cancer pain, and newer formulations such as the transmucosal and buccal forms have shown efficacy for the management of cancer-related breakthrough pain. This article reviews the pharmacodynamics, pharmacology, and clinical efficacy for this new option in treating moderate to severe pain.
authors.affiliation: Department of Hematology/Oncology/Palliative Care, Mayo Clinic Arizona, 5777 East Mayo Boulevard, Phoenix, AZ 85054, USA. prommer.eric@mayo.edu
authors.forename: Eric
authors.initials: E
authors.lastname: Prommer
mesh_terms: D000701:Analgesics, Opioid / Q000191:economics / Q000494:pharmacology / Q000627:therapeutic use*; D005283:Fentanyl / Q000191:economics / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D009369:Neoplasms / Q000150:complications*; D010146:Pain / Q000188:drug therapy* / Q000191:economics / Q000209:etiology; D010166:Palliative Care; D014481:United States
chemical_list: D000701:Analgesics, Opioid; D005283:Fentanyl