title: Neutralizing inter-clade cross-reactivity of HIV-1  V1/V2-specific secretory immunoglobulin A in  Colombian and French cohorts.
abstract: Neutralizing activity of secretory immunoglobulin A (S-IgA) directed against the V1/V2 domain of HIV-1 was studied in parotid saliva of HIV-1- infected patients in Colombian and French cohorts. Purified V1/V2-specific S-IgA antibodies were found to neutralize clades A, B and C primary isolates in five out 76 and 82 patients from each cohort, respectively. These results suggest that neutralizing S-IgA antibodies targeting the V1/V2 domain may provide protection against HIV-1 infection in vivo and may be beneficial in mucosal vaccines.
authors.affiliation: Groupe Immunité des Muqueuses et Agents Pathogènes, EA 3064, Université de Saint Etienne, Saint Etienne, France.
authors.forename: Viviana
authors.initials: V
authors.lastname: Granados-Gonzalez
authors.forename: Leidy Diana
authors.initials: LD
authors.lastname: Piedrahita
authors.forename: Marlen
authors.initials: M
authors.lastname: Martinez-Gutierrez
authors.forename: Philip
authors.initials: P
authors.lastname: Lawrence
authors.forename: Henia
authors.initials: H
authors.lastname: Saoudin
authors.forename: Ximena
authors.initials: X
authors.lastname: Zapata
authors.forename: Frederic
authors.initials: F
authors.lastname: Lucht
authors.forename: Abraham
authors.initials: A
authors.lastname: Pinter
authors.forename: Christian
authors.initials: C
authors.lastname: Genin
authors.forename: Silvio
authors.initials: S
authors.lastname: Urcuqui-Inchima
authors.forename: Serge
authors.initials: S
authors.lastname: Riffard
mesh_terms: D057134:Antibodies, Neutralizing / Q000276:immunology*; D015331:Cohort Studies; D003105:Colombia; D005260:Female; D005602:France; D015699:HIV Envelope Protein gp120 / Q000276:immunology; D015658:HIV Infections / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000276:immunology*; D008297:Male; D010446:Peptide Fragments / Q000276:immunology; D012463:Saliva / Q000276:immunology* / Q000821:virology
chemical_list: D057134:Antibodies, Neutralizing; D015699:HIV Envelope Protein gp120; C059761:HIV envelope protein gp120 (135-148); D007071:Immunoglobulin A, Secretory; D010446:Peptide Fragments