title: The effect of potassium bromate on some haematological parameters of Wistar rats.
abstract: Potassium bromate used widely in foods has been associated with various complications in humans. However there is paucity of literature on adverse effects on haematological parameters. Thus we decided to carry out an experimental study to determine the effects of potassium bromate on some blood indices using Wistar rats. Twenty (20) male Wistar rats aged 2-3 months obtained from the department of Veterinary Medicine, University of Nigeria Nsukka were acclimatized for two weeks. They were divided into five groups and fed with graded doses of potassium bromate solution for six weeks. One of the groups served as the control. Pre and post administration blood samples were collected and analyzed the same day using standard methods. The results revealed significant [P<0.05] decrease in the platelet count when compared with the controls. There were no statistically significant differences in the mean cell haemoglobin concentration, haematocrit, and total leukocyte counts between the test and control rats. Potassium bromate is injurious to health if consumed continuously and in high quantity. It has been shown to reduce platelet count in rats, and thus may cause thrombocytopenia in humans. It is therefore imperative to take adequate measures to eliminate the use of potassium bromate in the preparation of food products.
authors.affiliation: Department of Medical Laboratory Sciences, Faculty of Health Sciences and Technology, College of Medicine, University of Nigeria, Enugu Campus, and Department of Haematology, Neuropsychiatric Hospital Enugu, Nigeria.
authors.forename: P U
authors.initials: PU
authors.lastname: Achukwu
authors.forename: S A
authors.initials: SA
authors.lastname: Ufelle
authors.forename: E O
authors.initials: EO
authors.lastname: Ukaejiofo
authors.forename: F E
authors.initials: FE
authors.lastname: Ejezie
authors.forename: D N
authors.initials: DN
authors.lastname: Nwachukwu
authors.forename: U I
authors.initials: UI
authors.lastname: Nwagha
authors.forename: W C
authors.initials: WC
authors.lastname: Nworie
authors.forename: U S B
authors.initials: US
authors.lastname: Anyaehie
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000187:drug effects; D001959:Bromates / Q000633:toxicity*; D005503:Food Additives / Q000633:toxicity*; D006400:Hematocrit; D006454:Hemoglobins / Q000378:metabolism; D007958:Leukocyte Count; D007962:Leukocytes / Q000187:drug effects; D008297:Male; D010976:Platelet Count; D051381:Rats; D017208:Rats, Wistar; D018570:Risk Assessment
chemical_list: D001959:Bromates; D005503:Food Additives; D006454:Hemoglobins; C019536:potassium bromate