Relationship between carotid intima-media thickness and silent cerebral infarction in Japanese subjects with type 2 diabetes.
OBJECTIVE
We examined the relationship between intima-media thickness of common carotid artery (CCA-IMT) and silent cerebral infarction (SCI) with the magnetic resonance imaging (MRI) study in Japanese subjects with type 2 diabetes.


METHODS
The brain MRI study and the carotid ultrasonography were performed in a total of 217 consecutive Japanese subjects with type 2 diabetes. Various risk factors for SCI were examined using multiple logistic analyses.


RESULTS
The SCI was found in 60.4% of the diabetic subjects. In the diabetic subjects, age, systolic blood pressure (SBP), pulse wave velocity, and CCA-IMT were significantly higher in the subjects with SCI than in those without it. Multiple logistic analyses indicated that age, SBP, and CCA-IMT were significant and independent risk factors of SCI in the diabetic subjects.


CONCLUSIONS
CCA-IMT, but not pulse wave velocity, was independently associated with SCI in Japanese subjects with type 2 diabetes.
Nomura
Kazuhiro
K
Center for Diabetes and Endocrinology, Tazuke Kofukai Medical Research Institute, Kitano Hospital, Osaka, Japan. nomura-kob@umin.ac.jp
Hamamoto
Yoshiyuki
Y
Takahara
Shiho
S
Kikuchi
Osamu
O
Honjo
Sachiko
S
Ikeda
Hiroki
H
Wada
Yoshiharu
Y
Nabe
Koichro
K
Okumra
Ryosuke
R
Koshiyama
Hiroyuki
H
D000368:Aged; D044466:Asian People; D002544:Cerebral Infarction / Q000209:etiology* / Q000473:pathology*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D017539:Tunica Intima / Q000000981:diagnostic imaging / Q000473:pathology*; D017540:Tunica Media / Q000000981:diagnostic imaging / Q000473:pathology*; D014463:Ultrasonography