title: Colloids and crystalloids: does it matter to the kidney?
abstract: OBJECTIVE
  To highlight some of the recent key issues surrounding crystalloid and colloid fluid management of critically ill patients.
  
  
  RESULTS
  Significant developments have been made in the understanding of ionic balance of fluids and their effects on acid-base, the role of hydration and overhydration, alkalinization of fluids in patients at high risk for contrast induced nephropathy, and finally the role of colloids in acute kidney injury.
  
  
  CONCLUSIONS
  Despite hydration remaining a key principle in fluid management in many patients, volume overload is of considerable concern. Recent evidence also suggests that balanced electrolyte formulations are preferable to saline-based formulations in a variety of clinical settings. Furthermore, alkalinization of fluids is protective in the setting of contrast-induced nephropathy. Oncotic load appears to be the most important factor in acute kidney injury associated with colloid fluid therapy.
authors.affiliation: Department of Anesthesiology, DUMC 3094, Duke University Medical Center, Durham, North Carolina 27710, USA. tony.roche@duke.edu
authors.forename: Anthony M
authors.initials: AM
authors.lastname: Roche
authors.forename: Michael F M
authors.initials: MF
authors.lastname: James
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology; D003102:Colloids / Q000009:adverse effects*; D016638:Critical Illness; D000077324:Crystalloid Solutions; D005440:Fluid Therapy / Q000009:adverse effects; D006801:Humans; D007552:Isotonic Solutions / Q000009:adverse effects*; D007668:Kidney / Q000187:drug effects* / Q000293:injuries*
chemical_list: D003102:Colloids; D000077324:Crystalloid Solutions; D007552:Isotonic Solutions