title: Autologous tissue immediate breast reconstruction: desired but oncologically safe?
abstract: BACKGROUND
  There has been a dramatic increase in the incidence of immediate breast reconstruction after mastectomy for breast cancer over the past few decades and autologous tissue flaps are being used with increasing frequency. Concern has been expressed that these complex procedures may lead to a delay in the delivery of adjuvant therapy, which in turn may adversely affect recurrence and survival rates. Several publications have looked into the effect of immediate reconstruction on the timing of delivery of adjuvant therapy, but all types of immediate breast reconstruction (IBR) tend to be examined as a homogenous group.
  
  
  OBJECTIVE
  The aim of this review was to search current literature and look specifically at the effect of autologous tissue reconstructions on adjuvant therapy, and identify possible causes of delay.
  
  
  CONCLUSIONS
  From the data analysed, it appears that there may be a delay in the delivery of adjuvant therapy associated with autologous tissue IBR, especially transverse rectus abdominis muscle (TRAM) flaps. The studies available, however, examine small numbers of patients, which makes proving statistical significance difficult. Moreover, there also appears to be no consensus on what constitutes a delay in the delivery of adjuvant therapy. From 3% to 72% of autologous tissue IBR patients seem to receive their adjuvant treatment with a delay, according to the guidelines of the respective centres. Moreover, the period of time until chemotherapy appears generally increased from 13% to 36% compared with mastectomy alone patients. The most common reasons for delay are wound and flap complications.
  
  
  CONCLUSIONS
  At the moment, despite the increasing popularity of autologous IBR, these procedures have not proved their oncological safety. Further studies looking at the effect of IBR, especially TRAM flap reconstruction, are needed.
authors.affiliation: Breast Unit, Guy's Hospital, London SE1 9RT, UK.
authors.forename: R S
authors.initials: RS
authors.lastname: Lewis
authors.forename: M
authors.initials: M
authors.lastname: Kontos
mesh_terms: D001943:Breast Neoplasms / Q000601:surgery*; D003131:Combined Modality Therapy / Q000706:statistics & numerical data; D003695:Delivery of Health Care; D005260:Female; D006801:Humans; D016462:Mammaplasty / Q000379:methods*; D008408:Mastectomy / Q000379:methods*; D011183:Postoperative Complications / Q000209:etiology; D013524:Surgical Flaps; D013997:Time Factors; D014182:Transplantation, Autologous