Alkaloids from Piper sarmentosum and Piper nigrum.
Detailed chemical studies on the roots of Piper sarmentosum and Piper nigrum have resulted in several alkaloids. The roots of P. sarmentosum gave a new aromatic compound, 1-nitrosoimino-2,4,5-trimethoxybenzene (1). Piper nigrum roots gave pellitorine (2), (E)-1-[3',4'-(methylenedioxy)cinnamoyl]piperidine (3), 2,4-tetradecadienoic acid isobutyl amide (4), piperine (5), sylvamide (6), cepharadione A (7), piperolactam D (8) and paprazine (9). Structural elucidation of these compounds was achieved through NMR and MS techniques. Cytotoxic activity screening of the plant extracts indicated some activity.
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Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia. gwen@fsas.upm.edu.my
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Lim
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Rahmani
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Shaari
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Bong
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D000470:Alkaloids / Q000737:chemistry*; D001060:Aporphines / Q000737:chemistry; D052117:Benzodioxoles / Q000737:chemistry; D002470:Cell Survival / Q000187:drug effects; D005231:Fatty Acids, Unsaturated / Q000737:chemistry; D018922:HL-60 Cells; D006367:HeLa Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D031701:Piper / Q000737:chemistry*; D029222:Piper nigrum / Q000737:chemistry*; D010880:Piperidines / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D053284:Polyunsaturated Alkamides / Q000737:chemistry
D000470:Alkaloids; D001060:Aporphines; D052117:Benzodioxoles; D005231:Fatty Acids, Unsaturated; D010880:Piperidines; D053284:Polyunsaturated Alkamides; C488889:cepharadione A; C032727:piperidine; C008778:pellitorine; C008922:piperine