title: Trends in the epidemiology of human G1P[8] rotaviruses: a hungarian study.
abstract: Epidemiological trends of the globally most common rotavirus genotype, G1P[8], were investigated in Hungary during a 16-year period by sequencing and phylogenetic analysis of the surface antigens. Antigen shift among epidemiologically major G1P[8] strains was observed in 6 seasons, as indicated by changes in the sublineages of the G1 VP7 and the P[8] VP4 genes. The temporal clustering of some rotavirus VP4 and VP7 gene sublineages and the periodic emergence and/or resurgence of previously unrecognized rotavirus sublineages in the study population suggest a dynamic nature for these common strains. Recently established international strain surveillance networks may help to identify and track the spread of epidemiologically important rotavirus strains across countries and continents.
authors.affiliation: Regional Laboratory of Virology, Baranya County Institute of State Public Health Service, Hungarian Academy of Sciences, Budapest, Hungary. bkrota@hotmail.com
authors.forename: Krisztián
authors.initials: K
authors.lastname: Bányai
authors.forename: Jon R
authors.initials: JR
authors.lastname: Gentsch
authors.forename: Vito
authors.initials: V
authors.lastname: Martella
authors.forename: Agnes
authors.initials: A
authors.lastname: Bogdán
authors.forename: Viktória
authors.initials: V
authors.lastname: Havasi
authors.forename: Péter
authors.initials: P
authors.lastname: Kisfali
authors.forename: Alíz
authors.initials: A
authors.lastname: Szabó
authors.forename: Ilona
authors.initials: I
authors.lastname: Mihály
authors.forename: Péter
authors.initials: P
authors.lastname: Molnár
authors.forename: Béla
authors.initials: B
authors.lastname: Melegh
authors.forename: György
authors.initials: G
authors.lastname: Szücs
mesh_terms: D019943:Amino Acid Substitution; D000956:Antigens, Viral / Q000235:genetics; D036022:Capsid Proteins / Q000235:genetics; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D012401:Rotavirus / Q000145:classification / Q000235:genetics*; D012400:Rotavirus Infections / Q000453:epidemiology* / Q000821:virology; D013997:Time Factors
chemical_list: D000956:Antigens, Viral; D036022:Capsid Proteins; C060339:VP4 protein, Rotavirus; C050779:VP7 protein, Rotavirus