Predicting drug hypersensitivity by in vitro tests.
Recently it was found that drugs causing drug hypersensitivities do not only rely on the formation of hapten-carrier conjugates but can stimulate T cells directly via their T cell receptors for antigen. This new mechanism was termed pharmacological interaction of drugs with immune receptors (p-i concept). It is frequent in systemic drug hypersensitivity reactions and has major implications for predicting them. First experiments to identify such drugs able to interact with T cells are presented.
Pichler
Werner J
WJ
Department for Rheumatology and Clinical Immunology/Allergology, Inselspital, University of Bern, Bern, Switzerland. werner.pichler@insel.ch
D000485:Allergens / Q000276:immunology / Q000633:toxicity; D000937:Antigen-Antibody Reactions / Q000276:immunology; D000941:Antigens / Q000276:immunology; D004342:Drug Hypersensitivity / Q000276:immunology*; D006241:Haptens / Q000276:immunology; D006801:Humans; D009603:Nitroso Compounds / Q000276:immunology; D011237:Predictive Value of Tests; D011948:Receptors, Antigen, T-Cell / Q000276:immunology; D013420:Sulfamethoxazole / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D000485:Allergens; D000941:Antigens; D006241:Haptens; D009603:Nitroso Compounds; D011948:Receptors, Antigen, T-Cell; D013420:Sulfamethoxazole