title: Poor outcome of oesophageal adenocarcinoma after prior antireflux surgery.
abstract: OBJECTIVE
  Gastro-oesophageal reflux disease is an important risk factor for oesophageal adenocarcinoma, but abolishing reflux through surgery has not been shown to reduce this risk. The purpose of this study is to report on adenocarcinomas occurring after previous antireflux surgery and their long-term outcome.
  
  
  METHODS
  Six hundred and forty three patients underwent surgical resection in our unit for oesophagogastric adenocarcinoma between 2000 and 2009. Nine of these had antireflux surgery a median of 6.9 (mean of 9.3) years previously. Clinical and pathological characteristics and outcome (in terms of survival) are described for this patient group. The patients who had prior antireflux surgery were compared to matched control patients for disease free survival.
  
  
  RESULTS
  Disease free survival in our antireflux patients was 25.1% as compared to 72.1% in controls at 3 years. (Log rank test p=0.004).
  
  
  CONCLUSIONS
  Patients who have undergone antireflux surgery for chronic gastro-oesophageal reflux disease can develop adenocarcinoma and need to be monitored closely. The outcome following surgery appears greatly worse for patients with previous antireflux surgery than age/sex/stage/treatment matched controls in this small study.
authors.affiliation: Department of Upper Gastrointestinal Surgery, Norfolk and Norwich University Hospital, Norwich, UK.
authors.forename: E M
authors.initials: EM
authors.lastname: Mitchell
authors.forename: N
authors.initials: N
authors.lastname: Pal
authors.forename: J P
authors.initials: JP
authors.lastname: Kalyan
authors.forename: M
authors.initials: M
authors.lastname: Rhodes
authors.forename: M P N
authors.initials: MP
authors.lastname: Lewis
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality* / Q000473:pathology / Q000601:surgery*; D000368:Aged; D002423:Cause of Death; D016001:Confidence Intervals; D004938:Esophageal Neoplasms / Q000401:mortality* / Q000473:pathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D018662:Fundoplication / Q000009:adverse effects / Q000379:methods; D005764:Gastroesophageal Reflux / Q000175:diagnosis / Q000601:surgery*; D006801:Humans; D053208:Kaplan-Meier Estimate; D010535:Laparoscopy / Q000009:adverse effects / Q000379:methods; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000401:mortality; D011230:Precancerous Conditions / Q000473:pathology; D011336:Probability; D012189:Retrospective Studies; D018570:Risk Assessment; D012494:Sampling Studies; D018709:Statistics, Nonparametric; D016019:Survival Analysis