title: Effect of dietary Garcinia kola seed on selected serum electrolytes and trace metals in male Albino rats.
abstract: The effects of various doses of dietary intake of Garcinia kola seed powder [incorporated in animal feed at levels of 5% w/w, 10% w/w and 20% w/w and fed daily for six weeks] on serum levels of selected electrolytes [K+, Na+, CI-, HCO3-, Mg2+ and Ca2+] and trace metals [Cu2+, Zn2+ and Mn2+] were studied in male Albino rats [100-150 g body wt]. The pair-fed controls received basal feed diet daily for six weeks. Results showed a significant [P<0.05] dose dependent elevation of serum CI-, HCO3-, Ca2+, Mg2+, Cu2+, Zn2+ and Mn2+. These findings point to a possible relationship with already documented histopathology of various organs [such as the gonads] induced by Garcinia kola seed. It is also conjectured that the documented antibacterial, anti-inflammatory, anti-spasmodic, antidiabetic and antifertility effects of Garcinia kola seed may have underlying involvement of alterations in body levels of trace metals and electrolytes.
authors.affiliation: Department of Pharmacology, College of Medical Sciences University of Calabar, Calabar, Nigeria.
authors.forename: P O
authors.initials: PO
authors.lastname: Agada
authors.forename: V B
authors.initials: VB
authors.lastname: Braide
mesh_terms: D000818:Animals; D001639:Bicarbonates / Q000097:blood; D002118:Calcium / Q000097:blood; D003300:Copper / Q000097:blood; D004032:Diet; D004305:Dose-Response Relationship, Drug; D004573:Electrolytes / Q000097:blood*; D029763:Garcinia kola; D008274:Magnesium / Q000097:blood; D008297:Male; D008345:Manganese / Q000097:blood; D028321:Plant Preparations / Q000008:administration & dosage*; D011188:Potassium / Q000097:blood; D011208:Powders; D051381:Rats; D012639:Seeds; D012964:Sodium / Q000097:blood; D014131:Trace Elements / Q000097:blood*; D015032:Zinc / Q000097:blood
chemical_list: D001639:Bicarbonates; D004573:Electrolytes; D028321:Plant Preparations; D011208:Powders; D014131:Trace Elements; D008345:Manganese; D003300:Copper; D012964:Sodium; D008274:Magnesium; D015032:Zinc; D011188:Potassium; D002118:Calcium