title: Multicentric hyaline-vascular Castleman's disease in the retroperitoneum.
abstract: BACKGROUND
  Castleman's disease is a rare lymphoproliferative disease of unknown cause. Most multicentric cases described have been of the plasma-cell variety. This article presents a case of multicentric hyaline-vascular Castleman's disease in the retroperitoneum with the ultrasonographic and computed tomography (CT) imaging manifestations.
  
  
  METHODS
  During routine physical examination, a mass was detected in the left abdomen of a 53-year-old man with no signs or symptoms. The patient underwent ultrasound-guided aspiration biopsy and operative excision after laboratory examination, ultrasonography, and CT.
  
  
  RESULTS
  Ultrasonography demonstrated a dominant hypoechogenic mass with hypervascularity in the retroperitoneum. CT detected a relatively homogenous enhanced lesion and several satellite nodules. After the mass and several lymph nodes were resected, histopathologic examination demonstrated a lymphocyte-predominant infiltrate surrounding the germinal centres and extensive capillary proliferation, consistent with the hyaline-vascular type of Castleman's disease. The patient received postoperative chemotherapy and remained free of recurrence 3 months later.
  
  
  CONCLUSIONS
  Ultrasonography and contrast-enhanced CT can provide a positive differential diagnosis of hyaline-vascular Castleman's disease which is a kind of giant lymph node hyperplasia with hypervascularity.
authors.affiliation: Department of Hepatobiliary Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
authors.forename: Li-Ying
authors.initials: LY
authors.lastname: Wang
authors.forename: Tian-An
authors.initials: TA
authors.lastname: Jiang
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Teng
authors.forename: Qi-Yu
authors.initials: QY
authors.lastname: Zhao
authors.forename: Fen
authors.initials: F
authors.lastname: Chen
mesh_terms: D005871:Castleman Disease / Q000000981:diagnostic imaging* / Q000628:therapy; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D008875:Middle Aged; D012187:Retroperitoneal Space; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014463:Ultrasonography