[Variations of troponin T in chronic hemodialysis patients: study of 52 cases].
BACKGROUND
Patients with severe renal dysfunction have unexplained elevated serum concentrations of cardiac troponin T.


OBJECTIVE
Study the frequency of elevated cTnT in hemodialysis patients and investigated whether cTnT is elevated.


METHODS
The patient population consisted of 52 patients on maintenance hemodialysis and 20 healthy subjects. cTnT was measured before and after hemodialysis by using immunoenzymatic method. cTnT were undetectable in 7 cases(< 0.01 ng/ml) and higher than normal range (up to 0.1 ng/ml) in 9 cases. 32 cases have a level of cTnT > 0.01 and < 0.1 ng/ml. In addition, TnTc levels are significantly associated with cardiac dysfunction (p < 0.05) and inflammation (p 0.01).


RESULTS
After hemodialysis sessions, TnTc was less than 0.01 ng/1 in 11 patients (21.2%), between 0.01 and 0.1 ng/ml in 32 subjects (61.5%) and greater than 0.1 ng/ml in 9 subjects (17.3%). In the control group, only 1 subject (5%) had a rate of TnTc between 0.01 and 0.1 ng/ml, whereas it was less than 0.01 ng/ml for all others. We aim a statistically significant positive correlation between the rate of TnTc and heart failure (p < 0.05) on the one hand and serum CRP (p < 0.01) on the other.


CONCLUSIONS
The causes of elevated cTnT levels in hemodialysis patients was multiple: cardiac dysfunction, left ventricular dysfunction and inflammation.
Mnif
O
O
Services de Biochimie de l'Hôpital Charles Nicolle de Tunis.
Belhadj
R
R
Zerelli
L
L
Helal
I
I
El Younsi
F
F
Abdelmoula
J
J
Khedher
A
A
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D006435:Renal Dialysis; D020107:Troponin T / Q000097:blood*
D020107:Troponin T