Association between different levels of dysglycemia and metabolic syndrome in pregnancy.
BACKGROUND
In this study, we sought to evaluate the prevalence of metabolic syndrome (MS) in a cohort of pregnant women with a wide range of glucose tolerance, prepregnancy risk factors for MS during pregnancy, and the effects of MS in the outcomes in the mother and in the newborn.


METHODS
One hundred and thirty six women with positive screening for gestational diabetes mellitus (GDM) were classified by two diagnostic methods: glycemic profile and 100 g OGTT as normoglycemic, mild gestational hyperglycemic, GDM, and overt GDM. Markers of MS were measured between 2428th during the screening.


RESULTS
The prevalence of MS was: 0%; 20.0%; 23.5% and 36.4% in normoglycemic, mild hyperglycemic, GDM, and overt GDM groups, respectively. Previous history of GDM with or without insulin use, BMI >/= 25, hypertension, family history of diabetes in first degree relatives, non-Caucasian ethnicity, history of prematurity and polihydramnios were statistically significant prepregnancy predictors for MS in the index pregnancy, that by its turn increased the adverse outcomes in the mother and in the newborn.


CONCLUSIONS
The prevalence of MS increases with the worsening of glucose tolerance; impaired glycemic profile identifies pregnancies with important metabolic abnormalities even in the presence of a normal OGTT, in patients that are not classified as having GDM.
Negrato
Carlos A
CA
School of Medicine of Botucatu, São Paulo State University UNESP, Botucatu, São Paulo, Brazil. carlosnegrato@uol.com.br.
Jovanovic
Lois
L
Rafacho
Alex
A
Tambascia
Marcos A
MA
Geloneze
Bruno
B
Dias
Adriano
A
Rudge
Marilza Vc
MV