title: Evaluation of anti-inflammatory and antioxidant activities of Peltigera rufescens lichen species in acute and chronic inflammation models.
abstract: The anti-inflammatory effects of the methanol extract of the lichen species Peltigera rufescens (Weis.) Humb (MEPR) (Peltigeraceae) on acute (carrageenan-induced) and chronic (cotton pellet granule) phases of inflammation were investigated. The MEPR was capable of reducing carrageenan-induced inflammation and showed a potent antiproliferative effect (63.5%) in the chronic inflammation model. Inflammation is related to neutrophil infiltration and the production of neutrophil-derived mediators and free radicals. The MEPR reduced the myeloperoxidase and inducible nitric oxide synthase (NOS) activities, which were increased by carrageenan injection. Carrageenan injection also increased the lipid peroxidation (LPO) as compared with untreated paw tissues. The administration of MEPR, diclofenac, and indomethacin reduced the LPO in paw tissues through amelioration of the antioxidant defense systems. Neutrophil infiltration and neutrophil-derived free radicals in tissues therefore appeared to play an important role in the inflammation process induced by carrageenan. The anti-inflammatory effect of MEPR could be attributed to its reducing effect on the neutrophil-derived free radicals and its ameliorating effect on the antioxidant defense systems.
authors.affiliation: Department of Biochemistry, Faculty of Pharmacy, Ataturk University, Erzurum, Turkey.
authors.forename: Sevil
authors.initials: S
authors.lastname: Tanas
authors.forename: Fehmi
authors.initials: F
authors.lastname: Odabasoglu
authors.forename: Zekai
authors.initials: Z
authors.lastname: Halici
authors.forename: Ahmet
authors.initials: A
authors.lastname: Cakir
authors.forename: Hayati
authors.initials: H
authors.lastname: Aygun
authors.forename: Ali
authors.initials: A
authors.lastname: Aslan
authors.forename: Halis
authors.initials: H
authors.lastname: Suleyman
mesh_terms: D000208:Acute Disease; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification / Q000494:pharmacology*; D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology; D002351:Carrageenan; D002908:Chronic Disease; D004008:Diclofenac / Q000494:pharmacology; D004195:Disease Models, Animal; D007213:Indomethacin / Q000494:pharmacology; D007249:Inflammation / Q000188:drug therapy* / Q000503:physiopathology; D008011:Lichens / Q000737:chemistry*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D020556:Neutrophil Infiltration / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D010936:Plant Extracts; D004008:Diclofenac; D002351:Carrageenan; D007213:Indomethacin