Chikungunya virus takes centre stage in virally induced arthritis: possible cellular and molecular mechanisms to pathogenesis.
Chikungunya virus (CHIKV) causes an acute symptomatic illness with fever, skin rash (hypersensitivity vasculitis), incapacitating arthralgia which can evolve to chronic arthritis in elderly patients. Clinical observations from cohort studies have been corroborated with data from experimental infection in several mouse and non-human primate models as discussed herein.
Jaffar-Bandjee
Marie Christine
MC
Infection Research Grouping, University of la Réunion, St Denis, Ile de la Réunion.
Das
Trina
T
Hoarau
Jean Jacques
JJ
Krejbich Trotot
Pascale
P
Denizot
Mélanie
M
Ribera
Anne
A
Roques
Pierre
P
Gasque
Philippe
P
D000368:Aged; D000369:Aged, 80 and over; D018354:Alphavirus Infections / Q000276:immunology / Q000503:physiopathology / Q000821:virology; D000818:Animals; D001168:Arthritis / Q000821:virology*; D002646:Chikungunya virus / Q000472:pathogenicity*; D004195:Disease Models, Animal; D006801:Humans; D007231:Infant, Newborn; D051379:Mice