Acute toxicity of Schizolobium parahyba aqueous extract in mice.
The herbal extract of Schizolobium parahyba leaves is used commonly in the Brazil central region to treat snakebites. This study evaluates the acute toxicological effects of Schizolobium parahyba aqueous extract in mice 24 h after intraperitoneal administration. Acute toxicity was evaluated using biochemical, hematological and histopathological assays. Alterations in the levels of transaminases, bilirubin, albumin and prothrombrin time were observed, and these are likely to occur due to hepatic injury, which was confirmed by light microscopy. Liver histopathological analysis revealed the presence of lymph plasmocitary inflammatory infiltrate, but no other histopathological alterations were observed in any of the other organs analysed. The data confirm the low toxicity of the extract of Schizolobium parahyba and provide a model for the selection of a dose that does not cause injuries in the organism.
Mendes
Mirian M
MM
Laboratório de Química de Proteínas e Produtos Naturais, Instituto de Genética e Bioquímica, Universidade Federal de Uberlândia, Uberlândia-MG, Brazil. mirianmmendes@yahoo.com.br
Vale
Luis H F
LH
Lucena
Malson N
MN
Vieira
Sâmela A P B
SA
Izidoro
Luiz Fernando M
LF
Junior
Robson J O
RJ
Soares
Andreimar M
AM
Alcântara
Tânia M
TM
Hamaguchi
Amélia
A
Homsi-Brandeburgo
Maria Inês
MI
Rodrigues
Veridiana M
VM
D000418:Albumins / Q000032:analysis; D000818:Animals; D001663:Bilirubin / Q000097:blood; D001786:Blood Glucose; D003404:Creatinine / Q000097:blood; D007887:Fabaceae / Q000633:toxicity*; D007668:Kidney / Q000503:physiopathology; D008099:Liver / Q000473:pathology; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000633:toxicity*; D018515:Plant Leaves / Q000737:chemistry / Q000633:toxicity; D023382:Toxicity Tests, Acute
D000418:Albumins; D001786:Blood Glucose; D010936:Plant Extracts; D003404:Creatinine; D001663:Bilirubin