title: Chemotherapy-induced anemia in breast cancer patients treated with pegfilgrastim-supported dose-dense regimens.
abstract: The primary use of recombinant granulocyte colony-stimulating factors has reduced the incidence of febrile neutropenia during dose-dense adjuvant/neoadjuvant chemotherapy programs for breast cancer. Otherwise, in this population, filgrastim seems to worse chemotherapy-induced anemia, especially when administered with prolonged schedules that induced leukocytosis. No exhaustive data are available about the effect of long-lasting formulation of filgrastim (pegfilgrastim) on hemoglobin levels. We retrospectively analyzed the data regarding hemoglobin level and leukocyte count of 38 breast cancer patients treated with dose-dense anthracycline and/or taxane-based chemotherapy with pegfilgrastim support, both in adjuvant and in neoadjuvant settings. Mean hemoglobin levels progressively decreased throughout the treatment (without correlation with both the schedule of chemotherapy and the patient's age) but only two patients developed mild anemia. No significant correlation was found between the degree of leukocytosis and the hemoglobin decrease. These data suggest that pegfilgrastim, per se, doesn't seem to worse chemotherapy-induced anemia. This fact may be at least in part explains by its "balanced" impact on hematopoietic recovery during dose-dense chemotherapy.
authors.affiliation: Medical Oncology, Foundation IRCCS Policlinico S. Matteo, Piazzale C. Golgi 2, 27100 Pavia, Italy. mariangelamanzoni@libero.it
authors.forename: Mariangela
authors.initials: M
authors.lastname: Manzoni
authors.forename: Sara
authors.initials: S
authors.lastname: Delfanti
authors.forename: Bianca
authors.initials: B
authors.lastname: Rovati
authors.forename: Donatella
authors.initials: D
authors.lastname: Grasso
authors.forename: Sara
authors.initials: S
authors.lastname: Mariucci
authors.forename: Katia
authors.initials: K
authors.lastname: Bencardino
authors.forename: Carmine
authors.initials: C
authors.lastname: Tinelli
authors.forename: Marco
authors.initials: M
authors.lastname: Danova
mesh_terms: D000328:Adult; D000368:Aged; D000740:Anemia / Q000139:chemically induced*; D001943:Breast Neoplasms / Q000188:drug therapy*; D005260:Female; D000069585:Filgrastim; D016179:Granulocyte Colony-Stimulating Factor / Q000009:adverse effects*; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008875:Middle Aged; D011092:Polyethylene Glycols; D011994:Recombinant Proteins
chemical_list: D006454:Hemoglobins; D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; C455861:pegfilgrastim; D011092:Polyethylene Glycols; D000069585:Filgrastim