Role of the Fas/FasL pathway in HIV or SIV disease.
Human immunodeficiency virus disease involves progressive destruction of host immunity leading to opportunistic infections and increased rates for malignancies. Both depletion in immune cell numbers as well as defects in their effector functions are responsible for this immunodeficiency The broad impact of HIV reflects a similarly broad pattern of cell depletion including subsets that do not express viral receptors or support viral replication. Indirect cell killing, the destruction of uninfected cells, is due partly to activation of the Fas/FasL system for cell death. This death-signaling pathway is induced during HIV disease and contributes significantly to viral pathogenesis and disease.
Poonia
Bhawna
B
Institute of Human Virology, University of Maryland, School of Medicine, 725 W Lombard Street, Baltimore, MD 21201, USA. bpoonia@ihv.umaryland.edu
Pauza
C David
CD
Salvato
Maria S
MS
D000818:Animals; D016923:Cell Death; D053222:Fas Ligand Protein / Q000502:physiology*; D006678:HIV / Q000472:pathogenicity*; D015658:HIV Infections / Q000821:virology*; D000882:Haplorhini; D006801:Humans; D008954:Models, Biological; D016097:Simian Acquired Immunodeficiency Syndrome / Q000821:virology*; D015302:Simian Immunodeficiency Virus / Q000472:pathogenicity*; D019014:fas Receptor / Q000502:physiology*
D053222:Fas Ligand Protein; D019014:fas Receptor