title: [Autopsy case of rapidly progressive pulmonary spindle cell carcinoma with multiple metastases to the brain and pancreas].
abstract: A 53-year-old man was admitted to our hospital because of an abnormal lung shadow on his chest X-ray film. His symptoms were cough and shortness of breath. Chest X-ray and computed tomography showed a large mass lesion in the right lower lobe of the lung. We diagnosed primary non-small cell lung cancer; cT3N1M1 stage IV. Systemic chemotherapy using carboplatin and paclitaxcel was performed. However, the treatment had no effect and he died two months after admission. An autopsy showed pulmonary spindle cell carcinoma, with multiple metastases to the brain, pancreas, etc. Pulmonary spindle cell carcinoma had been recognized as a variant of the squamous cell carcinoma for years, however, in the recent WHO and Japanese classification of lung tumors, it was redefined as an independent histological type. It is a rare form of lung cancer, representing 0.2 to 0.3% of all primary pulmonary malignancies and seems to have poor prognosis. We need to pay more attention to this type of lung cancer.
authors.affiliation: National Hospital Organization Fukuoka-Higashi Medical Center.
authors.forename: Ken
authors.initials: K
authors.lastname: Tonai
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Kitasato
authors.forename: Takehito
authors.initials: T
authors.lastname: Kawakami
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Kondo
authors.forename: Takaomi
authors.initials: T
authors.lastname: Koga
authors.forename: Shohei
authors.initials: S
authors.lastname: Takata
authors.forename: Ritsuko
authors.initials: R
authors.lastname: Katafuchi
authors.forename: Masayuki
authors.initials: M
authors.lastname: Kawasaki
mesh_terms: D001344:Autopsy; D001932:Brain Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000556:secondary*; D002277:Carcinoma / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology / Q000556:secondary*; D018450:Disease Progression; D017809:Fatal Outcome; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000556:secondary*