title: Five furostanol saponins from fruits of Tribulus terrestris and their cytotoxic activities.
abstract: Two new furostanol saponins, terrestroside A, 3-O-{beta-D-xylopyranosyl-(1-->3)-[beta-D-xylopyranosyl(1-->2)]-beta-D-glucopyranosyl(1-->4)-[alpha-L-rhamnopyranosyl(1-->2)]-beta-D-galactopyranosy}-26-O-beta-D-glucopyranosyl-L-5a-furost-20(22)-en-(25R)-3beta,26-diol (1) and terrestroside B, 3-O-{beta-D-xylopyran-osyl(1-->3)-[beta-D-xylopyranosyl(1-->2)]-beta-D-glucopyranosyl(1-->4)-[alpha-L-rhamnopyranosyl-(1-->2)]-beta-D-galactopyranosy}-26-O-beta-D-glucopyranosyl-5a-furostan-12-one-(25R)-22-methoxy-3beta,26-diol (2), together with three known compounds, chloromaloside E (3), terrestrinin B (4) and terrestroneoside A (5) were isolated from the dry fruits of Tribulus terrestris. Furthermore, the inhibitory effects of the compounds on tumour cells were evaluated, and compounds 1-5 showed potential anti-tumour activity.
authors.affiliation: The Key Laboratory of Chemical Biology, Guangdong Province, Graduate School at Shenzhen, Tsinghua University, Guangdong 518055, PR China.
authors.forename: Jue
authors.initials: J
authors.lastname: Wang
authors.forename: Xuyu
authors.initials: X
authors.lastname: Zu
authors.forename: Yuyang
authors.initials: Y
authors.lastname: Jiang
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000494:pharmacology; D005638:Fruit / Q000737:chemistry*; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology; D012503:Saponins / Q000737:chemistry* / Q000494:pharmacology; D032444:Tribulus / Q000737:chemistry*
chemical_list: D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; D012503:Saponins