title: Synthesis, cytotoxic activity, and DNA binding properties of copper (II) complexes with hesperetin, naringenin, and apigenin.
abstract: Complexes of copper (II) with hesperetin, naringenin, and apigenin of general composition [CuL(2)(H(2)O)(2)] nH(2)O (1-3) have been synthesized and characterized by elemental analysis, UV-Vis, FT-IR, ESI-MS, and TG-DTG thermal analysis. The free ligands and the metal complexes have been tested in vitro against human cancer cell lines hepatocellular carcinoma (HepG-2), gastric carcinomas (SGC-7901), and cervical carcinoma (HeLa). Complexes 1 and 3 were found to exhibit growth inhibition of SGC-7901 and HepG2 cell lines with respect to the free ligands; the inhibitory rate of complex 1 is 43.2% and 43.8%, while complex 3 is 46% and 36%, respectively. The interactions of complex 1 and its ligand Hsp with calf thymus DNA were investigated by UV-Vis, fluorescence, and CD spectra. Both complex 1 and Hsp were found to bind DNA in intercalation modes, and the binding affinity of complex 1 was stronger than that of free ligand.
authors.affiliation: The Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry & Chemical Engineering, Guangxi Normal University, Guilin 541004, China.
authors.forename: Mingxiong
authors.initials: M
authors.lastname: Tan
authors.forename: Jinchan
authors.initials: J
authors.lastname: Zhu
authors.forename: Yingming
authors.initials: Y
authors.lastname: Pan
authors.forename: Zhenfeng
authors.initials: Z
authors.lastname: Chen
authors.forename: Hong
authors.initials: H
authors.lastname: Liang
authors.forename: Huagang
authors.initials: H
authors.lastname: Liu
authors.forename: Hengshan
authors.initials: H
authors.lastname: Wang