title: [Synthesis and in vitro cytotoxicity of naphthalimide polyamine conjugates as antitumor agents].
abstract: Six naphthalimide polyamine conjugates were synthesized and their structures were confirmed by elemental analysis, 1H NMR, 13C NMR and MS. Antitumor activities were evaluated in vitro using MTT assay on Leukemia cells (K562), human breast cancer cells (MB-231) and prostate cancer cells (Ln cap cell). The results showed that most of the six compounds were superior to the control (amonafide), 6d, 6e, and 6f exhibited nice selectivity in a screen of hepatoma cells (BEL-7402) and human normal hepatocytes (QSG-7701).
authors.affiliation: Key Laboratory of Natural Products and Immune Engineering, College of Chemistry and Techonology, Henan University, Kaifeng 475001, China.
authors.forename: Zi-Hou
authors.initials: ZH
authors.lastname: Mei
authors.forename: Zhi-Yong
authors.initials: ZY
authors.lastname: Tian
authors.forename: Hong-Xia
authors.initials: HX
authors.lastname: Ma
authors.forename: Song-Qiang
authors.initials: SQ
authors.lastname: Xie
authors.forename: Jin
authors.initials: J
authors.lastname: Zhao
authors.forename: Chao-Jie
authors.initials: CJ
authors.lastname: Wang
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D045744:Cell Line, Tumor / Q000187:drug effects; D006801:Humans; D008297:Male; D015394:Molecular Structure; D053644:Naphthalimides / Q000138:chemical synthesis* / Q000494:pharmacology*; D011073:Polyamines / Q000138:chemical synthesis / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D053644:Naphthalimides; D011073:Polyamines