Smoking as a predictor for loosing control of treated bronchial asthma.
OBJECTIVE
Analysis of the factors involved in uncontrolled bronchial asthma (BA).


METHODS
Between October 2007 and November 2008 we evaluated 584 consecutive patients, known and treated for BA, and collected general data, medical history, disease onset, spirometry, treatment duration, treatment, asthma control test (ACT). The association of variables was analyzed by calculating the odds ratio (OR) together with confidence intervals (CI) in a univariate analysis. The significant independent variables were utilized to create models of multivariate logistical analysis in order to identify the most important predictors.


RESULTS
584 patients, 162 males (27,74%), 422 females (72,26%), medium age 45,38 +/- 17,48 years (9-85), 14% smokers, ACT <19 (36,2%), 20-24 (48,8%), 25 (15%), 43,1% exacerbations, 4 predictors for uncontrolled BA: exacerbations OR 4,11, CI 3,30-7,48, p<0,001, professional exposure OR 2,29, CI 1,23-4,26, p=0,009, altered lung function on spirometry OR=1,18, CI 1,02-1,36, p=0,021 (obstruction OR 3,78 CI 1,76-7,78, p=0,0001), duration of disease (months) OR=1,02, CI 1,00-1,03, p=0,021, smoking OR 0,57, CI 0,26-0,71, p=0,012.


CONCLUSIONS
More than 1/3 (36,2%) of treated asthmatic patients had uncontrolled asthma. Smoking is not among the predictors for lack of control.
Mihăicuţă
Stefan
S
UMF "V. Babeş" Timişoara, V. Babeş Hospital, Romania. mihaicuta@yahoo.com
Ursoniu
Sorin
S
Dumitriu
Diana
D
Frenţ
Stefan
S
Firă-Mladinescu
Ovidiu
O
Tudorache
Voicu
V
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D018927:Anti-Asthmatic Agents / Q000627:therapeutic use; D001249:Asthma / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology*; D001985:Bronchial Provocation Tests / Q000379:methods; D002648:Child; D016001:Confidence Intervals; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D012129:Respiratory Function Tests / Q000379:methods*; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D012907:Smoking / Q000009:adverse effects*; D013147:Spirometry / Q000379:methods
D018927:Anti-Asthmatic Agents