[Severe cholestatic hepatitis due to Q fever: report of a case].
Severe cholestatic hepatitis due to Coxiella burnetii is a rare form of clinical presentation of acute Q fever that is only occasionally detected in association with this infectious disease. We report a case of severe cholestatic hepatitis due to acute Q fever, with clinical signs of hepatic insufficiency, marked cholestasis, and renal insufficiency. The results of the initial serologic study using a complement fixation test were negative on two occasions, and transjugular biopsy and serological analysis with indirect immunofluorescence were required to establish the diagnosis. Despite treatment with doxycycline and ciprofloxacin, the cholestasis progressively worsened, with the development of hepatic and renal insufficiency, which rapidly disappeared after corticosteroid treatment.
Suárez Ortega
Saturnino
S
Medicina Interna, Hospital General de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, España. drsuarez@hotmail.com
Rivero Vera
José
J
Hemmersbach
Marion
M
Artiles Campelo
Fernando
F
Reyes Pérez
Ricardo
R
Betancor León
Pedro
P
D002780:Cholestasis, Intrahepatic / Q000175:diagnosis / Q000382:microbiology*; D006505:Hepatitis / Q000175:diagnosis / Q000382:microbiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011778:Q Fever / Q000175:diagnosis; D012720:Severity of Illness Index