Antifungal active triterpene glycosides from sea cucumber Holothuria scabra.
To study the new antifungal active triterpene glycosides of sea cucumber Holothuria scabra. Triterpene glycosides from Holothuria scabra were separated and purified by silica gel chromatography, reversed-phase silica gel chromatography and RP-HPLC. Their structures were elucidated on the basis of spectral data and chemical evidence. Three triterpene glycosides were identified as scabraside A (1), echinoidea A (2) and holothurin A1 (3). Scabraside A (1) is a new triterpene glycoside, and compounds 2 and 3 were isolated from Holothuria scabra for the first time. They showed antifungal activities (1 < or = MIC80 < or = 16 microg mL(-1)).
Han
Hua
H
Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, Shanghai 200433, China.
Yi
Yang-Hua
YH
Li
Ling
L
Liu
Bao-Shu
BS
La
Ming-Ping
MP
Zhang
Hong-Wei
HW
D000818:Animals; D000935:Antifungal Agents / Q000302:isolation & purification* / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D047332:Holothuria / Q000737:chemistry*; D006697:Holothurin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000935:Antifungal Agents; D006027:Glycosides; D014315:Triterpenes; C562261:echinoidea A; C562260:holothurin A1; C548771:scabraside A; D006697:Holothurin