title: Inhibition of cAMP responsive element binding protein in striatal neurons enhances approach and avoidance responses toward morphine--and morphine withdrawal-related cues.
abstract: To investigate the role of cAMP responsive element binding protein (CREB)-dependent gene expression in morphine induced behaviors, we examined bitransgenic mice expressing a dominant and strong inhibitor of the CREB family of transcription factors, A-CREB, in striatal neurons in a regulatable manner. The expression of A-CREB in the striatum enhanced both morphine-induced conditioned place preference and morphine withdrawal-induced conditioned place avoidance. Our experiments thereby support a role for CREB in striatal neurons regulating approach and avoidance responses toward drug-related cues.
authors.affiliation: Area de Psicobiología, Universitat Jaume I de Castello Castello, Spain. csanchis@psb.uji.es
authors.forename: Carles
authors.initials: C
authors.lastname: Sanchis-Segura
authors.forename: Dragana
authors.initials: D
authors.lastname: Jancic
authors.forename: Maria
authors.initials: M
authors.lastname: Jimenez-Minchan
authors.forename: Angel
authors.initials: A
authors.lastname: Barco