Vitamin D and non-Hodgkin lymphoma risk in adults: a review.
Animal and human studies support a protective effect of vitamin D sufficiency related to malignancy by uncovering paracrine and autocrine effects of extra-renal 25-hydroxyvitamin D (25(OH)D) activation including regulation of cell cycle proliferation, apoptosis induction, and increased cell differentiation signaling. Recent epidemiologic studies demonstrate a reduction in non-Hodgkin lymphoma (NHL) risk with increased sunlight exposure. As sunlight is a major vitamin D source, it has been suggested that vitamin D status may mediate this observed association. This review provides a comprehensive discussion of the current epidemiologic evidence with regard to the investigation of an association between vitamin D status and NHL risk.
Kelly
Jennifer L
JL
Department of Community and Preventive Medicine, University of Rochester, Rochester, NY 14642, USA. jennifer_kelly@urmc.rochester.edu
Friedberg
Jonathan W
JW
Calvi
Laura M
LM
van Wijngaarden
Edwin
E
Fisher
Susan G
SG
D000328:Adult; D002112:Calcifediol / Q000378:metabolism; D019587:Dietary Supplements; D004100:Dihydroxycholecalciferols; D019317:Evidence-Based Medicine; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000209:etiology* / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control; D018673:Nutrition Policy; D018570:Risk Assessment; D012307:Risk Factors; D012621:Seasons; D015398:Signal Transduction; D014466:Ultraviolet Rays / Q000009:adverse effects; D014807:Vitamin D / Q000008:administration & dosage / Q000378:metabolism*; D014808:Vitamin D Deficiency / Q000150:complications* / Q000378:metabolism
D004100:Dihydroxycholecalciferols; D014807:Vitamin D; D002112:Calcifediol