Very late-onset group B Streptococcus meningitis, sepsis, and systemic shigellosis due to interleukin-1 receptor-associated kinase-4 deficiency.
We describe a child with very late-onset group B Streptococcus sepsis and meningitis, systemic shigellosis, and chronic osteomyelitis. Peripheral blood cells obtained from the patient and her brother did not respond to stimulation with either interleukin-1beta or lipopolysaccharide. Sequencing of the interleukin-1 receptor-associated kinase-4 gene revealed 2 novel mutations.
Krause
Jens C
JC
Department of Pediatrics, Division of Pediatric Infectious Diseases, Vanderbilt University, Nashville, Tennessee, USA.
Ghandil
Pegah
P
Chrabieh
Maya
M
Casanova
Jean-Laurent
JL
Picard
Capucine
C
Puel
Anne
A
Creech
C Buddy
CB
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D004405:Dysentery, Bacillary / Q000188:drug therapy / Q000235:genetics / Q000382:microbiology*; D005260:Female; D006801:Humans; D007223:Infant; D053592:Interleukin-1 Receptor-Associated Kinases / Q000172:deficiency* / Q000235:genetics; D008581:Meningitis / Q000188:drug therapy / Q000235:genetics / Q000382:microbiology*; D018805:Sepsis / Q000188:drug therapy / Q000235:genetics / Q000382:microbiology*; D013292:Streptococcus agalactiae / Q000472:pathogenicity*
D000900:Anti-Bacterial Agents; D053592:Interleukin-1 Receptor-Associated Kinases