Terpene glycosides and cytotoxic constituents from the seeds of Amomum xanthioides.
Column chromatographic isolation of the MeOH extract of the seeds of Amomum xanthioides afforded a new diterpene glycoside, amoxanthoside A (1), two new monoterpene glycosides, (1 S,4 S,5 S)-5- EXO-hydroxycamphor 5-O-beta-D-glucopyranoside (2) and (1 R,4 R,5 S)-5-ENDO-hydroxycamphor 5-O-beta-D-glucopyranoside (3), together with four known compounds, hedychiol A (4), pygmol (5), (1 S,4 R,6 R)-(+)-6- ENDO-hydroxycamphor (6), and dihydroyashabushiketol (7). The structures of the new compounds were determined through spectral analysis, including extensive 2D NMR data. The isolated compounds were tested for their cytotoxicity against four human cancer cell lines IN VITRO using a sulforhodamine B bioassay.
Kim
Ki Hyun
KH
Natural Products Laboratory, College of Pharmacy, Sungkyunkwan University, Suwon, Korea.
Choi
Jung Wook
JW
Choi
Sang Un
SU
Lee
Kang Ro
KR
D035801:Amomum / Q000737:chemistry*; D045744:Cell Line, Tumor; D003603:Cytotoxins / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D006801:Humans; D039821:Monoterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D012639:Seeds / Q000737:chemistry; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity
C549762:(1S,4S,5S)-5-exo-hydroxycamphor 5-O-beta-D-glucopyranoside; D003603:Cytotoxins; D006027:Glycosides; D039821:Monoterpenes; D010936:Plant Extracts; D013729:Terpenes