title: Gout in young migrant Filipino women in Israel: a changing epidemiology. Case reports and review of the literature.
abstract: Gout is rare among young women. The prevalence of gout is increasing in the western world and the Far East, probably owing to life style changes. The association between hyperuricemia and gout, the metabolic syndrome and atherosclerosis is stronger in women. 40 years ago, the increased prevalence of hyperuricemia and gout in Filipino men living in the United States was described. Recently, Filipino men and women living in the western world were found to have increased risk of the metabolic syndrome and atherosclerosis. We describe two unusual cases of gout in premenopausal Filipino women living in Israel, both of which suffered from hypertension. We also describe the current knowledge about gout in women, in general, and in migrant Asian women, in particular, with an emphasis on its relations to the metabolic syndrome and atherosclerosis. The occurrence of gout in relatively young migrant Filipino women might signal a change in the epidemiology of this disease, and might signal that these women are more prone to develop the metabolic syndrome and its complications.
authors.affiliation: Internal Department C, Bnai Zion Medical Center, P.O. Box 4940, 47 Golomb St, 31048, Haifa, Israel. ayeletshai1@gmail.com
authors.forename: Ayelet
authors.initials: A
authors.lastname: Shai
authors.forename: Doron
authors.initials: D
authors.lastname: Rimar
authors.forename: Michael
authors.initials: M
authors.lastname: Rozenbaum
authors.forename: Efrat
authors.initials: E
authors.lastname: Wolfovitz
authors.forename: Itzhak
authors.initials: I
authors.lastname: Rosner
mesh_terms: D000328:Adult; D001623:Betamethasone / Q000627:therapeutic use; D003078:Colchicine / Q000627:therapeutic use; D054242:Emigrants and Immigrants / Q000706:statistics & numerical data*; D005006:Ethnicity / Q000706:statistics & numerical data*; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006073:Gout / Q000175:diagnosis / Q000188:drug therapy / Q000208:ethnology*; D006074:Gout Suppressants / Q000627:therapeutic use; D006801:Humans; D007557:Israel / Q000453:epidemiology; D010679:Philippines / Q000208:ethnology; D011241:Prednisone / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D005938:Glucocorticoids; D006074:Gout Suppressants; D001623:Betamethasone; D003078:Colchicine; D011241:Prednisone