title: Prognostic factors for renal cell carcinoma: Trakya University experience from Turkey.
abstract: The purpose of the present study is to evaluate the prognostic factors of patients with renal cell carcinoma. The treatment results such as distant metastasis-free survival and overall survival of 59 previously untreated patients were retrospectively analysed. Median follow-up was 17.5 months (3.8-88.5 months). Overall survival was 22.4 months (3-87 months). Distant metastasis developed in 35 (59%) patients. The Eastern Cooperative Oncology Group (ECOG) performance status (P=0.022), tumour size (P=0.025) and lymphatic invasion (P<0.0001) were significantly effective prognostic factors for distant metastasis-free survival on multivariate analysis. Related to overall survival, gender (P=0.025), ECOG performance status (P=0.027), nuclear grade (P=0.002), tumour size (P=0.029), T stage (P=0.044), nodal involvement (P=0.003), surgical margin (P=0.046), renal sinus invasion (P<0.0001), perineural growth (P=0.001) and lymphatic invasion (P<0.0001) were significant prognostic factors on univariate analysis. Gender (P=0.008), ECOG performance status (P=0.027), tumour size (P=0.025) and lymphatic invasion (P<0.0001) retained their significance on multivariate analysis. We concluded that the most important prognostic factors for patients with renal cell carcinomas are ECOG performance status, tumour size and lymphatic invasion.
authors.affiliation: Department of Radiation Oncology, Faculty of Medicine, Trakya University, Edirne, Turkey. vuslatyurut@yahoo.com
authors.forename: V
authors.initials: V
authors.lastname: Yurut-Caloglu
authors.forename: M
authors.initials: M
authors.lastname: Caloglu
authors.forename: M
authors.initials: M
authors.lastname: Kaplan
authors.forename: F
authors.initials: F
authors.lastname: Oz-Puyan
authors.forename: H
authors.initials: H
authors.lastname: Karagol
authors.forename: K
authors.initials: K
authors.lastname: Ibis
authors.forename: R
authors.initials: R
authors.lastname: Cosar-Alas
authors.forename: Z
authors.initials: Z
authors.lastname: Kocak
authors.forename: O
authors.initials: O
authors.lastname: Inci
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002292:Carcinoma, Renal Cell / Q000401:mortality / Q000556:secondary / Q000628:therapy*; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D012720:Severity of Illness Index; D047368:Tumor Burden; D014421:Turkey