[Aggrecanases and osteoarthritis].
Osteoarthritis is mainly caused by the degenerative changes of cartilage and cartilage extracellular matrix, while Aggrecanases degradate Proteoglycans which are the major components of cartilage. This review includes three aspects: (1) We have concluded the major enzymes(ADAMTS-4 and ADAMTS-5) which regulate the metabolism of cartilage extracellular matrix. Meanwhile, we have summarized the structure of aggrecanases(ADAMTS-4 and ADAMTS-5) and introduced the function of each regional structure; (2) We have concluded the way cytokines and glycosaminoglycans regulate the metabolism of aggrecanases, and discussed the regulation and control principle of cytokines and glycosaminoglycan; (3) We have summarized the majority of inhibitors to the aggrecanases, introduced the endogenic inhibitors, and put our emphasis on the extrinsic inhibitors (chelating agents, polypeptides and so on). Through deeper research on the enzymes, it will help us further understand the pathogenesis of osteoarthritis, and open up new avenues to clinical treatment.
Li
Chao
C
Department of Biomedical Engineering, Peking University College of Engineering, Beijing 100871, China.
Cao
Yong Ping
YP
Guan
Zhen Peng
ZP
Huang
De Yong
de Y
Ge
Zi Gang
ZG
D051722:ADAM Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism*; D000071121:ADAMTS4 Protein; D000071116:ADAMTS5 Protein; D010450:Endopeptidases / Q000737:chemistry / Q000378:metabolism; D005109:Extracellular Matrix / Q000201:enzymology; D006801:Humans; D010003:Osteoarthritis / Q000201:enzymology* / Q000628:therapy; D011348:Procollagen N-Endopeptidase / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism*; D019717:Tissue Inhibitor of Metalloproteinase-3 / Q000494:pharmacology
C088390:TIMP3 protein, human; D019717:Tissue Inhibitor of Metalloproteinase-3; D010450:Endopeptidases; D051722:ADAM Proteins; D000071116:ADAMTS5 Protein; C121532:ADAMTS5 protein, human; D011348:Procollagen N-Endopeptidase; D000071121:ADAMTS4 Protein; C000603918:ADAMTS4 protein, human; C083641:aggrecanase