title: Single-nucleotide polymorphisms in peroxisome proliferator-activated receptor gamma and their association with plasma levels of resistin and the metabolic syndrome in a South Indian population.
abstract: Studies on the association of the Pro12Ala and C1431T polymorphisms of PPAR? with diabetes and obesity have revealed extensive population-dependent variations. However, association of these polymorphisms with the metabolic syndrome and its individual components has not been well investigated in the Indian population. The Indian population harbours the maximum number of diabetics in the world who are thus more susceptible to metabolic disorders. We screened a South Indian population (N=699) for a possible association of these polymorphisms with the metabolic syndrome (MS) and type 2 diabetes. We also investigated the correlation of these two single-nucleotide polymorphisms (SNPs) with plasma resistin levels. The C1431T SNP was associated with higher levels of plasma resistin (P=0.017). Furthermore, C1431T was associated with resistin in different tertiles. Prevalence of the 'Pro-C' haplotype decreased with increasing tertiles of resistin (84.1% to 75.4%, P=0.037). Plasma resistin levels were not found to be associated with MS and type 2 diabetes. These results point to a likely association of plasma resistin levels with PPAR? polymorphisms in the Indian population.
authors.affiliation: Molecular Biology Unit, National Institute of Nutrition, Jamai Osmania, Hyderabad 500 604, India.
authors.forename: Abdul
authors.initials: A
authors.lastname: Haseeb
authors.forename: Mohammad
authors.initials: M
authors.lastname: Iliyas
authors.forename: Subhabrata
authors.initials: S
authors.lastname: Chakrabarti
authors.forename: Arif A
authors.initials: AA
authors.lastname: Farooqui
authors.forename: Sudhir R
authors.initials: SR
authors.lastname: Naik
authors.forename: Sudip
authors.initials: S
authors.lastname: Ghosh
authors.forename: Madhuri
authors.initials: M
authors.lastname: Suragani
authors.forename: Nasreen Z
authors.initials: NZ
authors.lastname: Ehtesham
mesh_terms: D000368:Aged; D000483:Alleles; D015331:Cohort Studies; D005260:Female; D005787:Gene Frequency; D005843:Geography; D006239:Haplotypes; D006801:Humans; D007194:India / Q000453:epidemiology; D008297:Male; D024821:Metabolic Syndrome / Q000235:genetics*; D008875:Middle Aged; D047495:PPAR gamma / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D015995:Prevalence; D052243:Resistin / Q000097:blood* / Q000235:genetics*
chemical_list: D047495:PPAR gamma; D052243:Resistin