title: Brønsted acid activation of alpha-diazo imide: a syn-selective glycolate Mannich reaction.
abstract: A novel alpha-diazo imide reagent and its activation by strong Brønsted acid is shown to produce the product of a syn-glycolate Mannich transform with high diastereoselection.
authors.affiliation: Department of Chemistry & Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN 37235-1822, USA.
authors.forename: Timothy L
authors.initials: TL
authors.lastname: Troyer
authors.forename: Hubert
authors.initials: H
authors.lastname: Muchalski
authors.forename: Jeffrey N
authors.initials: JN
authors.lastname: Johnston
mesh_terms: D000143:Acids / Q000737:chemistry; D006016:Glycolates / Q000737:chemistry*; D007094:Imides / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000143:Acids; D006016:Glycolates; D007094:Imides; C031149:glycolic acid