title: Effect of Costaria costata fucoidan on expression of matrix metalloproteinase-1 promoter, mRNA, and protein.
abstract: Fucoidans are sulfated fucosylated polymers from brown algae cell walls. We assessed the inhibitory effects of Costaria costata fucoidan on UVB-induced MMP-1 promoter, mRNA, and protein expression in vitro using the immortalized human keratinocyte (HaCaT) cell line. Pretreatment with fucoidan significantly inhibited MMP-1 protein expression compared to UVB irradiation alone. Fucoidan significantly reduced MMP-1 mRNA expression and inhibited UVB-induced MMP-1 promoter activity by 37.3%, 53.3%, and 58.5% at 0.01, 0.1, and 1 microg/mL, respectively, compared to UVB irradiation alone. C. costata fucoidan may be a potential therapeutic agent to prevent and treat skin photoaging.
authors.affiliation: Institute of Natural Products for Health Promotion and Department of Preventive Medicine, College of Medicine, Kosin University, Busan, 602-702, Korea.
authors.forename: Hee Jung
authors.initials: HJ
authors.lastname: Moon
authors.forename: Kyong Sik
authors.initials: KS
authors.lastname: Park
authors.forename: Mi Jeong
authors.initials: MJ
authors.lastname: Ku
authors.forename: Myeong Sook
authors.initials: MS
authors.lastname: Lee
authors.forename: Seok Hoon
authors.initials: SH
authors.lastname: Jeong
authors.forename: Tatyana I
authors.initials: TI
authors.lastname: Imbs
authors.forename: Tatyana N
authors.initials: TN
authors.lastname: Zvyagintseva
authors.forename: Svetlana P
authors.initials: SP
authors.lastname: Ermakova
authors.forename: Yong Hwan
authors.initials: YH
authors.lastname: Lee
mesh_terms: D002473:Cell Wall / Q000737:chemistry; D006801:Humans; D020781:Matrix Metalloproteinase 1 / Q000187:drug effects / Q000235:genetics*; D000459:Phaeophyceae / Q000737:chemistry*; D011134:Polysaccharides / Q000494:pharmacology*; D011506:Proteins / Q000187:drug effects / Q000378:metabolism; D012333:RNA, Messenger / Q000187:drug effects / Q000378:metabolism; D015595:Skin Aging / Q000187:drug effects*; D014466:Ultraviolet Rays
chemical_list: D011134:Polysaccharides; D011506:Proteins; D012333:RNA, Messenger; C007789:fucoidan; D020781:Matrix Metalloproteinase 1