title: [Long term renal outcome of children born preterm: a regular follow-up is needed].
abstract: Most of the published studies evaluating renal prognosis of children born very preterm found asymptomatic abnormalities (blood pressure, glomerular filtration rate GFR, hypercalciuria, decreased renal size, microalbuminuria...) during childhood or early adulthood. The objective of this study was to assess renal function (inulin clearance) in a prospective single-center cohort of children born preterm between 1998 and 2001 (< 30 GW,<1000 g) and to identify neonatal risk factors for renal abnormalities during childhood. Fifty children were included in the final part of the study. At a mean age of 7.6 years, no patient had arterial hypertension or chronic kidney disease, but mean centile for diastolic blood pressure was higher than expected and ultrasounds revealed small-sized kidneys compared to controls. The average GFR was 112 ml/min per 1.73 m(2) (91-158). Two children had microalbuminuria, two had hypercalciuria and one had nephrocalcinosis. Children with intra- or extra-uterine growth retardation had an impaired GFR compared to children with appropriate pre- and post-natal growth (107 vs. 110 vs. 125 ml/min per 1.73 m(2), p<0.05). Children with bronchopulmonary dysplasia had a significant higher microalbuminuria. In conclusion, findings of borderline blood pressure and reduced kidney size in children born preterm can be regarded as markers of reduced nephron number. Long term renal follow-up (blood pressure, serum creatinine, urine albumin / creatinine ratio) should be performed in all children born very preterm, with an early referring when abnormalities are highlighted.
authors.affiliation: Centre de Référence des Maladies Rénales Rares, Service de Néphrologie et Rhumatologie Pédiatriques, Hôpital Femme Mère Enfant, Bron, France. justine.bacchetta@chu-lyon.fr
authors.forename: J
authors.initials: J
authors.lastname: Bacchetta
authors.forename: J
authors.initials: J
authors.lastname: Harambat
authors.forename: B
authors.initials: B
authors.lastname: Guy
authors.forename: G
authors.initials: G
authors.lastname: Putet
authors.forename: P
authors.initials: P
authors.lastname: Cochat
authors.forename: L
authors.initials: L
authors.lastname: Dubourg
mesh_terms: D000419:Albuminuria / Q000453:epidemiology; D001794:Blood Pressure / Q000502:physiology; D002648:Child; D002908:Chronic Disease; D015331:Cohort Studies; D003404:Creatinine / Q000097:blood; D005317:Fetal Growth Retardation; D005500:Follow-Up Studies; D006801:Humans; D053565:Hypercalciuria / Q000453:epidemiology; D007231:Infant, Newborn; D007234:Infant, Premature / Q000502:physiology*; D007444:Inulin / Q000378:metabolism; D007674:Kidney Diseases / Q000453:epidemiology; D007677:Kidney Function Tests; D009397:Nephrocalcinosis / Q000453:epidemiology; D012017:Referral and Consultation; D012307:Risk Factors
chemical_list: D007444:Inulin; D003404:Creatinine