Six-year experience: long-term disease control outcomes for partial breast irradiation using MammoSite balloon brachytherapy.
BACKGROUND
This report describes estimated 4-year tumor bed and ipsilateral breast recurrence-free intervals, event-free survival, disease-specific survival, and overall survival in a cohort of MammoSite brachytherapy (MBT) patients with mature follow-up treated at a single institution over a 6-year period.


METHODS
An analysis of MBT cases was performed by using a prospectively collected quality-assurance database, departmental chart review, and electronic medical records. Patient-, tumor-, treatment-, and outcome-specific data were extracted and recorded into a research database. Patients were eligible for inclusion in this analysis if they were at least 6 months post-MBT.


RESULTS
From May 2002 through March 2008, 111 MBT patients have been treated and were eligible for the present analysis. With a median follow-up of 46 months, the estimated 4-year outcomes for the entire cohort were tumor bed control 99%, ipsilateral breast control 95%, event-free survival 88%, disease-specific survival 97%, and overall survival 92%.


CONCLUSIONS
The present study shows low rates of local and ipsilateral breast disease failure in a well-defined cohort of MBT patients with mature follow-up.
Harper
Jennifer L
JL
Department of Radiation Oncology, Medical University of South Carolina, Hollings Cancer Center, 169 Ashley Ave. MSC 318 Charleston, SC 29425, USA. harperjl@musc.edu
Watkins
John M
JM
Zauls
A Jason
AJ
Wahlquist
Amy E
AE
Garrett-Mayer
Elizabeth
E
Baker
Megan K
MK
Cole
David J
DJ
Dragun
Anthony E
AE
Jenrette
Joseph M
JM
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001918:Brachytherapy / Q000295:instrumentation / Q000379:methods*; D001943:Breast Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D002404:Catheterization; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D015412:Mastectomy, Segmental; D008875:Middle Aged; D011446:Prospective Studies; D018714:Radiotherapy, Adjuvant / Q000379:methods; D016019:Survival Analysis