title: [Preliminary study of vulvar and vaginal intraepithelial neoplasias].
abstract: OBJECTIVE
  To detect the clinical features of vulvar and vaginal intraepithelial neoplasias (VIN and VAIN, respectively).
  
  
  METHODS
  Total 148 women were performed vulvar or vaginal coloposcopy-directed biopsy pathology tests, from Sep. 2004 to Dec. 2007.
  
  
  RESULTS
  Among 148 women, vulvar or vaginal histologic results were vulvar cancer for 1, VIN or VAIN 2, 3 for 23, VIN or VAIN for 16, condyloma for 61, vulvitis and vaginitis for 47. Eighty-five percent (33/39) women with VIN or VAIN 2, 3 were more than 30 years old. Compared to women with cervical intraepithelial neoplasia (CIN), women with VIN or VAIN were older. The rate of high-risk HPV DNA in women with vulvar or vaginal lesions was 84% (84/100). VAIN occurred mainly in the upper vagina (90%, 69/75). VIN or VAIN often accompanied or followed CIN or cervical cancer (79%, 31/39), and VIN or VAIN 2, 3 often accompanied or followed CIN 2, 3 or cervical cancer (70%, 16/23).
  
  
  CONCLUSIONS
  Our data suggest that women with high-risk HPV infection are at risk of developing VIN or VAIN 2, 3. The vulva and vagina should be carefully inspected by colposcopic examination at the time of colposcopy for any abnormal findings.
authors.affiliation: Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China.
authors.forename: Yan Li
authors.initials: YL
authors.lastname: Guo
authors.forename: Li
authors.initials: L
authors.lastname: Geng
authors.forename: Ke
authors.initials: K
authors.lastname: You
authors.forename: Jie
authors.initials: J
authors.lastname: Qiao
authors.forename: Cong-rong
authors.initials: CR
authors.lastname: Liu
mesh_terms: D000328:Adult; D002278:Carcinoma in Situ / Q000473:pathology* / Q000821:virology; D003127:Colposcopy; D004279:DNA, Viral / Q000097:blood; D005260:Female; D006801:Humans; D008875:Middle Aged; D027383:Papillomaviridae / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000150:complications*; D012307:Risk Factors; D014625:Vaginal Neoplasms / Q000473:pathology* / Q000821:virology; D014846:Vulvar Neoplasms / Q000473:pathology* / Q000821:virology
chemical_list: D004279:DNA, Viral