Mapping of quantitative trait loci affecting classical scrapie incubation time in a population comprising several generations of scrapie-infected sheep.
Although susceptibility to scrapie is largely controlled by the PrP gene, the role of other genes that affect scrapie resistance in sheep is now confirmed. Following the detection of quantitative trait loci (QTL) on chromosomes 6 and 18 in a half-sib family with an ARQ/VRQ susceptible PrP genotype, the whole pedigree of a naturally infected flock was investigated to confirm these QTL regions in different PrP genotypes. The present study has allowed us to confirm the QTL on chromosome 18, and to demonstrate the QTL effects in several PrP genotypes.
Moreno
Carole R
CR
INRA, UR631, Amélioration Génétique des Animaux, BP52627, 31326 Castanet-Tolosan, France. Moreno@toulouse.inra.fr
Moazami-Goudarzi
Katayoun
K
Briand
Stephanie
S
Robert-Granié
Christèle
C
Weisbecker
Jean Louis
JL
Laurent
Pascal
P
Cribiu
Edmond-Paul
EP
Haley
Christopher S
CS
Andréoletti
Olivier
O
Bishop
Stephen C
SC
Pong-Wong
Ricardo
R
D000818:Animals; D002874:Chromosome Mapping; D005260:Female; D020022:Genetic Predisposition to Disease; D008297:Male; D010375:Pedigree; D018621:PrPC Proteins / Q000235:genetics; D040641:Quantitative Trait Loci; D012608:Scrapie / Q000235:genetics* / Q000473:pathology; D012756:Sheep / Q000235:genetics*; D013997:Time Factors
D018621:PrPC Proteins