title: Luteolin increases the expression of GRP94 in HeLa cells.
abstract: We found increased expression of GRP94, the 94-kDa glucose-regulated protein, in HeLa cells 24 h after treatment with luteolin. Luteolin increased the levels of GRP94 mRNA and protein, but it did not increase the expression of unfolded protein response (UPR)-regulated genes. In addition, luteolin also enhanced GRP94 promoter activity, suggesting that it enhances the expression of GRP94 at the transcriptional level, not via the UPR signaling pathway.
authors.affiliation: Department of Environmental Biochemistry, Graduate School of Medicine, Chiba University, Japan.
authors.forename: Gaofeng
authors.initials: G
authors.lastname: Hu
authors.forename: Toshikazu
authors.initials: T
authors.lastname: Suzuki
authors.forename: Mei
authors.initials: M
authors.lastname: Dong
authors.forename: Qin-Wen
authors.initials: QW
authors.lastname: Shi
authors.forename: Bing
authors.initials: B
authors.lastname: Cong
authors.forename: Nobuo
authors.initials: N
authors.lastname: Suzuki
mesh_terms: D018840:HSP70 Heat-Shock Proteins / Q000235:genetics* / Q000378:metabolism*; D006367:HeLa Cells; D006801:Humans; D047311:Luteolin / Q000494:pharmacology*; D008565:Membrane Proteins / Q000235:genetics* / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D015854:Up-Regulation / Q000187:drug effects*
chemical_list: D018840:HSP70 Heat-Shock Proteins; D008565:Membrane Proteins; D012333:RNA, Messenger; C018551:glucose-regulated proteins; D047311:Luteolin