title: Working memory and long-term memory deficits in schizophrenia: is there a common substrate?
abstract: Patients with schizophrenia exhibit substantial deficits in both working memory (WM) and long-term memory (LTM) tasks. While these two forms of memory are generally viewed as distinct, recent evidence from healthy subjects has challenged the robustness of the double-dissociation between these two types of memory. In light of an emerging view of WM and LTM as being subserved by a largely overlapping network of brain regions, it is possible that WM and LTM deficits in patients with schizophrenia share a common neurobiological substrate. This review revisits the functional neuroimaging literature on both WM and LTM in patients with schizophrenia with these considerations in mind, and reveals a number of commonalities in research findings in both literatures. While there is a paucity of direct evidence bearing on whether patient deficits in these tasks arise from a common functional abnormality, the available literature is consistent with the hypothesis that these deficits have the same origin.
authors.affiliation: Department of Psychology, Columbia University, New York, NY 10027, United States. jared@psych.columbia.edu
authors.forename: Jared Xavier
authors.initials: JX
authors.lastname: Van Snellenberg
mesh_terms: D001931:Brain Mapping; D003072:Cognition Disorders / Q000209:etiology; D003952:Diagnostic Imaging / Q000379:methods; D006801:Humans; D008568:Memory / Q000145:classification*; D008569:Memory Disorders / Q000209:etiology* / Q000473:pathology*; D012559:Schizophrenia / Q000150:complications*; D012565:Schizophrenic Psychology