Anesthesia and the old brain.
The perioperative period may have long-term consequences on cognitive function in the elderly patient. In this special article, we summarize the rationale and evidence that the anesthetic per se is a contributor. The evidence at this point is considered suggestive and further research is needed, especially in humans.
Tang
Junxia
J
Department of Anesthesiology and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
Eckenhoff
Maryellen F
MF
Eckenhoff
Roderic G
RG
D000368:Aged; D000544:Alzheimer Disease / Q000139:chemically induced / Q000473:pathology; D000758:Anesthesia / Q000009:adverse effects; D018685:Anesthetics, Inhalation / Q000009:adverse effects*; D000818:Animals; D001921:Brain / Q000187:drug effects*; D003072:Cognition Disorders / Q000139:chemically induced / Q000209:etiology; D003704:Dementia / Q000139:chemically induced* / Q000209:etiology; D006801:Humans; D016874:Neurofibrillary Tangles / Q000187:drug effects
D018685:Anesthetics, Inhalation