title: 25-hydroxyvitamin D in cerebrospinal fluid during relapse and remission of multiple sclerosis.
abstract: Hypovitaminosis D may play a role in multiple sclerosis (MS), but little is known about intrathecal vitamin D. 25-Hydroxyvitamin D was measured in cerebrospinal fluid and sera from 36 patients with relapsing-remitting MS, 20 patients with other inflammatory neurological diseases and 18 patients with non-inflammatory neurological diseases with liquid chromatography-mass spectrometry. There were no significant differences in cerebrospinal fluid concentrations of 25-hydroxyvitamin D, but the cerebrospinal fluid:serum ratio was significantly lower in MS compared with other inflammatory neurological diseases (p=0.0012) and non-inflammatory neurological diseases (p=0.041) patients. The concentrations of 25-hydroxyvitamin D in cerebrospinal fluid and serum were positively correlated and their ratio was similar to that of albumin. Neither the concentrations of 25-hydroxyvitamin D in cerebrospinal fluid or serum nor their ratio were associated with the presence of relapses or gadolinium-enhanced lesions. These results do not support that 25-hydroxyvitamin D is actively transported to the cerebrospinal fluid, or that the cerebrospinal fluid or serum levels or their ratio exert a major impact on MS activity.
authors.affiliation: Institute of Immunology, Faculty of Medicine, University of Oslo, Oslo, Norway. trygve.holmoy@rr-research.no
authors.forename: Trygve
authors.initials: T
authors.lastname: Holmøy
authors.forename: Stine Marit
authors.initials: SM
authors.lastname: Moen
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Gundersen
authors.forename: Michael F
authors.initials: MF
authors.lastname: Holick
authors.forename: Enrico
authors.initials: E
authors.lastname: Fainardi
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Castellazzi
authors.forename: Ilaria
authors.initials: I
authors.lastname: Casetta
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000473:pathology; D002117:Calcitriol / Q000134:cerebrospinal fluid*; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007249:Inflammation / Q000134:cerebrospinal fluid / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D013058:Mass Spectrometry; D008875:Middle Aged; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000134:cerebrospinal fluid* / Q000473:pathology; D009422:Nervous System Diseases / Q000134:cerebrospinal fluid / Q000473:pathology; D012008:Recurrence; D012621:Seasons; D055815:Young Adult
chemical_list: D007074:Immunoglobulin G; D002117:Calcitriol