title: External trial deep brain stimulation device for the application of desynchronizing stimulation techniques.
abstract: In the past decade deep brain stimulation (DBS)-the application of electrical stimulation to specific target structures via implanted depth electrodes-has become the standard treatment for medically refractory Parkinson's disease and essential tremor. These diseases are characterized by pathological synchronized neuronal activity in particular brain areas. We present an external trial DBS device capable of administering effectively desynchronizing stimulation techniques developed with methods from nonlinear dynamics and statistical physics according to a model-based approach. These techniques exploit either stochastic phase resetting principles or complex delayed-feedback mechanisms. We explain how these methods are implemented into a safe and user-friendly device.
authors.affiliation: Institute of Neuroscience and Medicine, Neuromodulation INM-7 and Virtual Institute of Neuromodulation, Forschungszentrum Jülich, Leo-Brandt-Str., D-52425 Jülich, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Hauptmann
authors.forename: J-C
authors.initials: JC
authors.lastname: Roulet
authors.forename: J J
authors.initials: JJ
authors.lastname: Niederhauser
authors.forename: W
authors.initials: W
authors.lastname: Döll
authors.forename: M E
authors.initials: ME
authors.lastname: Kirlangic
authors.forename: B
authors.initials: B
authors.lastname: Lysyansky
authors.forename: V
authors.initials: V
authors.lastname: Krachkovskyi
authors.forename: M A
authors.initials: MA
authors.lastname: Bhatti
authors.forename: U B
authors.initials: UB
authors.lastname: Barnikol
authors.forename: L
authors.initials: L
authors.lastname: Sasse
authors.forename: C P
authors.initials: CP
authors.lastname: Bührle
authors.forename: E-J
authors.initials: EJ
authors.lastname: Speckmann
authors.forename: M
authors.initials: M
authors.lastname: Götz
authors.forename: V
authors.initials: V
authors.lastname: Sturm
authors.forename: H-J
authors.initials: HJ
authors.lastname: Freund
authors.forename: U
authors.initials: U
authors.lastname: Schnell
authors.forename: P A
authors.initials: PA
authors.lastname: Tass
mesh_terms: D001921:Brain / Q000503:physiopathology*; D046690:Deep Brain Stimulation / Q000295:instrumentation* / Q000379:methods*; D004869:Equipment Safety / Q000295:instrumentation / Q000379:methods; D005246:Feedback; D006801:Humans; D008959:Models, Neurological; D017711:Nonlinear Dynamics; D012815:Signal Processing, Computer-Assisted / Q000295:instrumentation; D013269:Stochastic Processes; D013997:Time Factors; D014584:User-Computer Interface