The capsid protein of human immunodeficiency virus: interactions of HIV-1 capsid with host protein factors.
HIV-1 is a retrovirus that causes AIDS in humans. The RNA genome of the virus encodes a Gag polyprotein, which is further processed into matrix, capsid and nucleocapsid proteins. These proteins play a significant role at several steps in the viral life cycle. In addition, various stages of assembly, infection and replication of the virus involve necessary interactions with a large number of supplementary proteins/cofactors within the infected host cell. This minireview focuses on the proteomics of the capsid protein, its influence on the packaging of nonviral molecules into HIV-1 virions and the subsequent role of the molecules themselves. These interactions and their characterization present novel frontiers for the design and advancement of antiviral therapeutics.
Mascarenhas
Anjali P
AP
Department of Chemistry, The Ohio State University, Columbus, OH, USA.
Musier-Forsyth
Karin
K
D000090103:Antiviral Restriction Factors; D036022:Capsid Proteins / Q000737:chemistry / Q000502:physiology*; D002352:Carrier Proteins / Q000502:physiology; D021984:Cyclophilin A / Q000502:physiology; D015497:HIV-1 / Q000737:chemistry / Q000502:physiology*; D006801:Humans; D008250:Lysine-tRNA Ligase / Q000502:physiology; D000070584:Tripartite Motif Proteins; D044767:Ubiquitin-Protein Ligases; D019065:Virus Assembly
D000090103:Antiviral Restriction Factors; D036022:Capsid Proteins; D002352:Carrier Proteins; D000070584:Tripartite Motif Proteins; C477346:TRIM5 protein, human; D044767:Ubiquitin-Protein Ligases; D021984:Cyclophilin A; D008250:Lysine-tRNA Ligase