Lyophilization of biological standards.
Freeze drying plays a vital part in the preparation of many biological reference materials. The general approaches that may be adopted in the application of lyophilization to these biomolecules are discussed and the importance of analytical methodology and formulation optimization emphasised. Examples are given from a number of recently processed materials.
Matejtschuk
Paul
P
Centre for Biological Reference Materials, National Institute for Biological Standards & Control, Blanche Lane, South Mimms, Potters Bar, Hertfordshire EN6 3QG, UK. pmatejt@nibsc.ac.uk
D000818:Animals; D000911:Antibodies, Monoclonal; D015925:Cryopreservation / Q000379:methods*; D004055:Differential Thermal Analysis; D005612:Freeze Drying; D006801:Humans; D010949:Plasma; D012015:Reference Standards
D000911:Antibodies, Monoclonal