title: Sequence variations at the human leukocyte antigen-linked olfactory receptor cluster do not influence female preferences for male odors.
abstract: We previously reported that paternally inherited human leukocyte antigen (HLA) alleles are a template for women's preferences for male odors (p = 0.0007). However, it has been suggested that sequence variation in a nearby olfactory receptor (OR) cluster on chromosome 6p influences smell preference. To determine whether the HLA-linked OR genes contribute to previously observed HLA-mediated behaviors, we use the odor preference data from our earlier study in combination with a new resequencing study of four functional, HLA-linked OR genes in the same subjects. Our results indicate that OR alleles in the genes surveyed are not in linkage disequilibrium with HLA variation and do not explain the previous findings of HLA-associated odor preference.
authors.affiliation: Department of Human Genetics, The University of Chicago, Chicago, Illinois, USA. eethomps@uchicago.edu
authors.forename: Emma E
authors.initials: EE
authors.lastname: Thompson
authors.forename: Gabe
authors.initials: G
authors.lastname: Haller
authors.forename: Jayant M
authors.initials: JM
authors.lastname: Pinto
authors.forename: Ying
authors.initials: Y
authors.lastname: Sun
authors.forename: Bethanne
authors.initials: B
authors.lastname: Zelano
authors.forename: Suma
authors.initials: S
authors.lastname: Jacob
authors.forename: Martha K
authors.initials: MK
authors.lastname: McClintock
authors.forename: Dan L
authors.initials: DL
authors.lastname: Nicolae
authors.forename: Carole
authors.initials: C
authors.lastname: Ober
mesh_terms: D000293:Adolescent; D000328:Adult; D001483:Base Sequence; D002896:Chromosomes, Human, Pair 6; D005260:Female; D008040:Genetic Linkage; D006680:HLA Antigens / Q000235:genetics* / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D005810:Multigene Family; D055696:Olfactory Perception; D049049:Pheromones, Human / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide; D018035:Receptors, Odorant / Q000235:genetics*; D012727:Sex Characteristics; D055815:Young Adult
chemical_list: D006680:HLA Antigens; D049049:Pheromones, Human; D018035:Receptors, Odorant