The NIH Human Microbiome Project.
The Human Microbiome Project (HMP), funded as an initiative of the NIH Roadmap for Biomedical Research (http://nihroadmap.nih.gov), is a multi-component community resource. The goals of the HMP are: (1) to take advantage of new, high-throughput technologies to characterize the human microbiome more fully by studying samples from multiple body sites from each of at least 250 "normal" volunteers; (2) to determine whether there are associations between changes in the microbiome and health/disease by studying several different medical conditions; and (3) to provide both a standardized data resource and new technological approaches to enable such studies to be undertaken broadly in the scientific community. The ethical, legal, and social implications of such research are being systematically studied as well. The ultimate objective of the HMP is to demonstrate that there are opportunities to improve human health through monitoring or manipulation of the human microbiome. The history and implementation of this new program are described here.
Peterson
Jane
J
Garges
Susan
S
Giovanni
Maria
M
McInnes
Pamela
P
Wang
Lu
L
Schloss
Jeffery A
JA
Bonazzi
Vivien
V
McEwen
Jean E
JE
Wetterstrand
Kris A
KA
Deal
Carolyn
C
Baker
Carl C
CC
Di Francesco
Valentina
V
Howcroft
T Kevin
TK
Karp
Robert W
RW
Lunsford
R Dwayne
RD
Wellington
Christopher R
CR
Belachew
Tsegahiwot
T
Wright
Michael
M
Giblin
Christina
C
David
Hagit
H
Mills
Melody
M
Salomon
Rachelle
R
Mullins
Christopher
C
Akolkar
Beena
B
Begg
Lisa
L
Davis
Cindy
C
Grandison
Lindsey
L
Humble
Michael
M
Khalsa
Jag
J
Little
A Roger
AR
Peavy
Hannah
H
Pontzer
Carol
C
Portnoy
Matthew
M
Sayre
Michael H
MH
Starke-Reed
Pamela
P
Zakhari
Samir
S
Read
Jennifer
J
Watson
Bracie
B
Guyer
Mark
M
D001419:Bacteria / Q000145:classification / Q000235:genetics / Q000302:isolation & purification; D005260:Female; D041981:Gastrointestinal Tract / Q000382:microbiology*; D006801:Humans; D054892:Metagenome / Q000235:genetics*; D009055:Mouth / Q000382:microbiology*; D009313:National Health Programs; D009316:National Institutes of Health (U.S.); D012336:RNA, Ribosomal, 16S / Q000235:genetics; D017422:Sequence Analysis, DNA; D012867:Skin / Q000382:microbiology*; D014481:United States; D014621:Vagina / Q000382:microbiology*
D012336:RNA, Ribosomal, 16S