Statins as anti-arrhythmics: a systematic review part II: effects on risk of ventricular arrhythmias.
BACKGROUND
Recent studies have demonstrated that statins may possess anti-arrhythmic properties in addition to their lipid-lowering effects.


METHODS
Studies which reported the association of statins with the incidence of ventricular arrhythmias were identified through a systematic review of the published literature.


RESULTS
Statins have been associated with a significant reductions in ventricular arrhythmia in cardiomyopathy patients with an implantable cardioverter defibrillator, although randomized trials have not been completed.


CONCLUSIONS
Published data suggests that statins may possess anti-arrhythmic properties that reduce the propensity for ventricular arrhythmias. Most of this data is observational; more randomized, placebo-controlled trials are needed.
Abuissa
Hussam
H
University of Missouri, Kansas City, Missouri, USA. abuissa.hussam@mayo.edu
O'Keefe
James H
JH
Bybee
Kevin A
KA
D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000209:etiology / Q000517:prevention & control*; D003131:Combined Modality Therapy; D016757:Death, Sudden, Cardiac / Q000209:etiology / Q000517:prevention & control; D017147:Defibrillators, Implantable; D019317:Evidence-Based Medicine; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D012307:Risk Factors; D055502:Secondary Prevention; D016896:Treatment Outcome
D000889:Anti-Arrhythmia Agents; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors