title: Effects of added mannitol on the setting reaction and mechanical strength of apatite cement.
abstract: Apatite cement containing porogen can be a useful material for the fabrication of biporous (macro- and microporous) apatite, which has gained much attention as a bone substitute material because of its large surface area and that it improves cell penetration. In the present study, the effects of added mannitol on the setting reaction and mechanical strength of apatite cement were evaluated. Apatite cements containing 0-40 wt% of mannitol were prepared and allowed to set in 0.9% saline kept at 37 degrees C for 1-7 days. Although the diametral tensile strength (DTS) value increased with time, it decreased with the amount of added mannitol. SEM observation and XRD analysis revealed that mannitol had no inhibitory effect on the transformation reaction of apatite cement to apatite. It was thus concluded that mannitol was a good candidate for the fabrication of biporous apatite because it is biocompatible, exhibits satisfactory dissolution behavior, and that it caused no inhibitory effects on the compositional transformation to apatitic material.
authors.affiliation: Japan Institute for Advanced Dentistry, Minato-ku, Tokyo 105-0014, Japan.
authors.forename: Ryoji
authors.initials: R
authors.lastname: Shimogoryo
authors.forename: Toru
authors.initials: T
authors.lastname: Eguro
authors.forename: Eiichiro
authors.initials: E
authors.lastname: Kimura
authors.forename: Michito
authors.initials: M
authors.lastname: Maruta
authors.forename: Shigeki
authors.initials: S
authors.lastname: Matsuya
authors.forename: Kunio
authors.initials: K
authors.lastname: Ishikawa
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry; D001843:Bone Cements / Q000737:chemistry*; D018786:Bone Substitutes / Q000737:chemistry; D002809:Chondroitin Sulfates / Q000737:chemistry* / Q000648:ultrastructure; D003460:Crystallization; D004338:Drug Combinations; D006882:Hydroxyapatites / Q000737:chemistry*; D008353:Mannitol / Q000737:chemistry*; D008422:Materials Testing; D013314:Stress, Mechanical; D013386:Succinates / Q000737:chemistry*; D013402:Sugar Alcohols / Q000737:chemistry; D054457:Tissue Scaffolds / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; C481019:Biopex; D001843:Bone Cements; D018786:Bone Substitutes; D004338:Drug Combinations; D006882:Hydroxyapatites; D013386:Succinates; D013402:Sugar Alcohols; D008353:Mannitol; D002809:Chondroitin Sulfates