Development of mammary luminal progenitor cells is controlled by the transcription factor STAT5A.
Mammary alveologenesis is abrogated in the absence of the transcription factors STAT5A/5B, which mediate cytokine signaling. To reveal the underlying causes for this developmental block, we studied mammary stem and progenitor cells. While loss of STAT5A/5B did not affect the stem cell population and its ability to form mammary ducts, luminal progenitors were greatly reduced and unable to form alveoli during pregnancy. Temporally controlled expression of transgenic STAT5A in mammary epithelium lacking STAT5A/5B restored the luminal progenitor population and rescued alveologenesis in a reversible fashion in vivo. Thus, STAT5A is necessary and sufficient for the establishment of luminal progenitor cells.
Yamaji
Daisuke
D
Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
Na
Risu
R
Feuermann
Yonatan
Y
Pechhold
Susanne
S
Chen
Weiping
W
Robinson
Gertraud W
GW
Hennighausen
Lothar
L
D000818:Animals; D005260:Female; D018507:Gene Expression Regulation, Developmental; D008321:Mammary Glands, Animal / Q000166:cytology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D011247:Pregnancy; D050799:STAT5 Transcription Factor / Q000235:genetics / Q000378:metabolism*; D013234:Stem Cells / Q000166:cytology*
D050799:STAT5 Transcription Factor