title: The integration of chemotherapy and surgery for bladder cancer.
abstract: Despite surgery with curative intent, approximately 50% of patients with muscle-invasive transitional cell carcinoma of the bladder will develop distant metastases and succumb to their disease. Attempts to improve outcomes have focused on refining surgical techniques and integrating perioperative chemotherapy. This review summarizes the available literature addressing the role of pelvic lymphadenectomy, neoadjuvant chemotherapy, and adjuvant chemotherapy in the management of patients with muscle-invasive transitional cell carcinoma of bladder.
authors.affiliation: Genitourinary Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Hospital for Cancer and Allied Diseases, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA. Galskym@mskcc.org
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Galsky
authors.forename: Harry W
authors.initials: HW
authors.lastname: Herr
authors.forename: Dean E
authors.initials: DE
authors.lastname: Bajorin
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols; D002295:Carcinoma, Transitional Cell / Q000628:therapy*; D017024:Chemotherapy, Adjuvant; D015653:Cystectomy; D006801:Humans; D008197:Lymph Node Excision; D019990:Perioperative Care; D001749:Urinary Bladder Neoplasms / Q000628:therapy*
chemical_list: D000970:Antineoplastic Agents