title: Resectable pancreatic adenocarcinoma: is the enhancement pattern at contrast-enhanced ultrasonography a pre-operative prognostic factor?
abstract: The aim of our study was to determine whether the enhancement pattern of pancreatic adenocarcinoma at contrast-enhanced ultrasonography (CEUS) is related to patient prognosis after resection. CEUS of 42 resected adenocarcinomas were retrospectively reviewed. Tumors were divided into two groups: group A=poorly vascularized (presence of avascular areas) or group B=well vascularized (absence of avascular areas). All lesions were resected and underwent pathological examination assessing tumor differentiation as: undifferentiated (poorly differentiated) or differentiated (moderately and well differentiated). Mean vascular density (MVD) was also evaluated. CEUS enhancement and pathology were correlated (Spearman's test). Survival was analyzed with the Kaplan-Meier method. Multivariate analysis was performed with the Cox regression model. There were 30 differentiated and 12 undifferentiated adenocarcinomas at pathology. At CEUS, 10 lesions were poorly vascularized, whereas 32 lesions were well vascularized. Positive correlation was observed between CEUS groups and tumoral differentiation (rs=0.51; p=0.001) and between CEUS and MVD (rs=0.74; p<0.0001). Median survival in patients with group A vascularization at CEUS was significantly lower than in group B (p=0.015). Cox proportional hazard model revealed the presence of poorly vascularized tumor at CEUS (p=0.0001) as a predictor of higher mortality. In conclusion, CEUS enables accurate depiction of the vascularization of adenocarcinoma, with positive correlation to histology grade and MVD.
authors.affiliation: Department of Radiology, University Hospital G.B. Rossi, Verona, Italy. mirko.donofrio@univr.it
authors.forename: M
authors.initials: M
authors.lastname: D'Onofrio
authors.forename: G A
authors.initials: GA
authors.lastname: Zamboni
authors.forename: R
authors.initials: R
authors.lastname: Malagò
authors.forename: W
authors.initials: W
authors.lastname: Mantovani
authors.forename: F
authors.initials: F
authors.lastname: Principe
authors.forename: A
authors.initials: A
authors.lastname: Gallotti
authors.forename: N
authors.initials: N
authors.lastname: Faccioli
authors.forename: M
authors.initials: M
authors.lastname: Falconi
authors.forename: P
authors.initials: P
authors.lastname: Capelli
authors.forename: R Pozzi
authors.initials: RP
authors.lastname: Mucelli
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging* / Q000401:mortality / Q000601:surgery*; D000368:Aged; D003287:Contrast Media; D005260:Female; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D010180:Pancreatectomy / Q000401:mortality*; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging* / Q000401:mortality / Q000601:surgery*; D011300:Preoperative Care / Q000706:statistics & numerical data; D015995:Prevalence; D011379:Prognosis; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D016019:Survival Analysis; D015996:Survival Rate; D016896:Treatment Outcome; D014463:Ultrasonography / Q000706:statistics & numerical data*
chemical_list: D003287:Contrast Media