An "ice-cold" TR(i)P to skin biology: the role of TRPA1 in human epidermal keratinocytes.
Recent studies have suggested the expression of numerous heat-sensitive transient receptor potential (TRP) ion channels in non-neuronal cell populations of the skin. In this issue, Atoyan et al. provide evidence that the noxious cold-activated TRPA1 is widely expressed in various human cutaneous cells and that it may be directly involved in the regulation of keratinocyte proliferation and differentiation and in cutaneous inflammatory responses.
Bíró
Tamás
T
Department of Physiology, University of Debrecen, Research Center for Molecular Medicine, Debrecen, Hungary. biro@phys.dote.hu
Kovács
László
L
D015220:Calcium Channels / Q000502:physiology*; D002454:Cell Differentiation; D049109:Cell Proliferation; D006801:Humans; D015603:Keratinocytes / Q000166:cytology / Q000502:physiology*; D009419:Nerve Tissue Proteins / Q000502:physiology*; D000074025:TRPA1 Cation Channel; D050916:TRPV Cation Channels / Q000502:physiology; D050051:Transient Receptor Potential Channels / Q000502:physiology*
D015220:Calcium Channels; D009419:Nerve Tissue Proteins; D000074025:TRPA1 Cation Channel; C473350:TRPA1 protein, human; D050916:TRPV Cation Channels; C459445:TRPV3 protein, human; D050051:Transient Receptor Potential Channels