In vivo siRNA delivery with dendritic poly(L-lysine) for the treatment of hypercholesterolemia.
Intravenous delivery of apolipoprotein B-specific siRNA with a sixth-generation of dendritic poly(L-lysine) (KG6) resulted in siRNA-mediated knockdown of ApoB in healthy C57BL/6 mice without hepatotoxicity, and with a significant reduction of serum low-density lipoprotein cholesterol in apolipoprotein E-deficient mice.
Watanabe
Kazuto
K
Department of Applied Chemistry, Faculty of Engineering, Kyushu University, Fukuoka 819-0395, Japan.
Harada-Shiba
Mariko
M
Suzuki
Akira
A
Gokuden
Risa
R
Kurihara
Ryohsuke
R
Sugao
Yusuke
Y
Mori
Takeshi
T
Katayama
Yoshiki
Y
Niidome
Takuro
T
D000818:Animals; D001055:Apolipoproteins B / Q000235:genetics / Q000502:physiology; D050091:Dendrimers / Q000138:chemical synthesis / Q000737:chemistry*; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry*; D006937:Hypercholesterolemia / Q000188:drug therapy*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D011107:Polylysine / Q000138:chemical synthesis / Q000737:chemistry*; D034741:RNA, Small Interfering / Q000008:administration & dosage* / Q000737:chemistry / Q000502:physiology*; D020133:Reverse Transcriptase Polymerase Chain Reaction
D001055:Apolipoproteins B; D050091:Dendrimers; D004337:Drug Carriers; D034741:RNA, Small Interfering; D011107:Polylysine