Gut immune balance is as easy as S-F-B.
Microbes appear to modulate homeostatic plasticity of T helper and T regulatory cells. In this issue of Immunity, Gaboriau-Routhiau et al. (2009) now reveal that segmented filamentous bacteria uniquely coordinate the intestinal T cell profile. The potential implications of this process to various immune functions are discussed.
Mazmanian
Sarkis K
SK
Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA.
D000818:Animals; D001419:Bacteria / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology* / Q000378:metabolism / Q000382:microbiology; D016207:Cytokines / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000276:immunology* / Q000382:microbiology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology* / Q000378:metabolism / Q000382:microbiology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology* / Q000378:metabolism / Q000382:microbiology
D016207:Cytokines