title: Forward modelling of magnetic induction tomography: a sensitivity study for detecting haemorrhagic cerebral stroke.
abstract: For a magnetic induction tomography (MIT) system operating at 10 MHz, the signals produced by a haemorrhagic cerebral stroke were computed using an anatomically realistic, multi-layer, finite element (FE) head model comprising 12 tissues. The eddy-current problem was approximated using the commercial FE package, Comsol Multiphysics, and the numerical techniques employed were validated using a benchmark test. Mesh convergence for the head model was investigated for first- and second-order elements. MIT signals were computed for strokes of different sizes and locations in the brain to judge the sensitivity of the MIT configuration. The results revealed that for a large peripheral stroke (volume 50 cm(3)), 27% of the signals were above the phase noise level achievable in our current data-collection hardware (approximately 20 m degrees). In order to detect the same percentage of the signals due to a centrally located small stroke, a reduction in phase noise to 1 m degrees was necessary.
authors.affiliation: School of Medicine, Swansea University, Swansea, UK.
authors.forename: M
authors.initials: M
authors.lastname: Zolgharni
authors.forename: P D
authors.initials: PD
authors.lastname: Ledger
authors.forename: H
authors.initials: H
authors.lastname: Griffiths
mesh_terms: D001931:Brain Mapping / Q000379:methods; D002543:Cerebral Hemorrhage / Q000175:diagnosis*; D006801:Humans; D008280:Magnetics; D008953:Models, Anatomic; D012680:Sensitivity and Specificity; D012815:Signal Processing, Computer-Assisted; D020521:Stroke / Q000175:diagnosis*; D014054:Tomography / Q000379:methods