title: Raltegravir, etravirine and r-darunavir combination in adolescents with multidrug-resistant virus.
abstract: Twelve heavily pretreated, perinatally infected adolescents in virological failure were treated with a combination of raltegravir, r-darunavir and etravirine, as part of an expanded access program in France. After a 12-month median follow-up, viral load was <400 copies/ml in 11 (<50 in six). No grade > 2 side effects were recorded. Additional data and marketing authorizations are awaited, but preliminary results in adolescents with extensive multidrug resistant virus are encouraging.
authors.affiliation: Service d'Hématologie Pédiatrique, CHU Timone, Marseille, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Thuret
authors.forename: Marie-Laure
authors.initials: ML
authors.lastname: Chaix
authors.forename: Catherine
authors.initials: C
authors.lastname: Tamalet
authors.forename: Véronique
authors.initials: V
authors.lastname: Reliquet
authors.forename: Ghislaine
authors.initials: G
authors.lastname: Firtion
authors.forename: Joëlle
authors.initials: J
authors.lastname: Tricoire
authors.forename: Christian
authors.initials: C
authors.lastname: Rabaud
authors.forename: Pierre
authors.initials: P
authors.lastname: Frange
authors.forename: Hugues
authors.initials: H
authors.lastname: Aumaître
authors.forename: Stéphane
authors.initials: S
authors.lastname: Blanche
mesh_terms: D000293:Adolescent; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D000069454:Darunavir; D024921:Drug Resistance, Multiple, Viral; D004359:Drug Therapy, Combination / Q000379:methods; D005260:Female; D005602:France / Q000453:epidemiology; D015658:HIV Infections / Q000188:drug therapy* / Q000453:epidemiology / Q000821:virology; D015497:HIV-1; D006801:Humans; D008297:Male; D009570:Nitriles; D011724:Pyridazines / Q000627:therapeutic use; D011743:Pyrimidines; D011760:Pyrrolidinones / Q000627:therapeutic use; D000068898:Raltegravir Potassium; D013449:Sulfonamides / Q000627:therapeutic use; D016896:Treatment Outcome; D019562:Viral Load
chemical_list: D019380:Anti-HIV Agents; D044966:Anti-Retroviral Agents; D009570:Nitriles; D011724:Pyridazines; D011743:Pyrimidines; D011760:Pyrrolidinones; D013449:Sulfonamides; C451734:etravirine; D000068898:Raltegravir Potassium; D000069454:Darunavir