Effects of emissions from different type of residential heating upon cyclic guanosine monophosphate (cGMP) in blood platelets of residents.
We hypothesized that different types of residential heating would be associated with different levels of indoor carbon monoxide (CO) and further that this might result in a differential in the concentration of cyclic 3':5' guanosine monophosphate (cGMP) in blood platelets in exposed residents. Individuals, who were recruited from homes using different fuel for heating, donated a venous blood sample in the winter and in the summer. In the winter the median blood platelet cGMP value for the group using liquid propane gas (LPG) was 65% higher than for the group using piped natural gas for heating (p <0.001). Also in the group using LPG, the median concentration of cGMP in the winter was 39% higher than the summer median (p < 0.003). The mean indoor concentrations of CO were measured over a period of 1 week during the winter and were <1 ppm. We conclude that observed differences were associated with emissions from different types of heating but that CO exposure alone is too low to explain these.
Matthews
I P
IP
Department of Primary Care and Public Health, Cardiff University, Heath Park, Cardiff, UK. Matthewsip@cardiff.ac.uk
Henderson
K A
KA
Gregory
C
C
Palmer
S R
SR
Lang
D
D
D000368:Aged; D016902:Air Pollution, Indoor / Q000032:analysis*; D001792:Blood Platelets / Q000737:chemistry*; D002248:Carbon Monoxide / Q000032:analysis; D006152:Cyclic GMP / Q000032:analysis*; D005579:Fossil Fuels; D006361:Heating; D006801:Humans; D008875:Middle Aged; D011407:Propane; D012621:Seasons
D005579:Fossil Fuels; D002248:Carbon Monoxide; D006152:Cyclic GMP; D011407:Propane