title: Managing non-paraneoplastic Lambert-Eaton myasthenic syndrome: clinical characteristics in 25 German patients.
abstract: In about 40% of patients LEMS is not a paraneoplastic phenomenon (NT-LEMS). Several clinical aspects important to these patients remain open, especially the question when a LEMS can definitely be diagnosed as NT-LEMS. Here we describe a series of 25 German NT-LEMS patients regarding their clinical characteristics, duration of symptoms, value of serological markers, paraneoplastic antibodies and FDG-PET/CT. Furthermore, we discuss the current diagnostic criteria of NT-LEMS.
authors.affiliation: Institute for Clinical Neuroimmunology, Ludwig Maximilians University of Munich, 81377 Munich, Germany. hannah.pellkofer@med.uni-muenchen.de
authors.forename: Hannah L
authors.initials: HL
authors.lastname: Pellkofer
authors.forename: Lena
authors.initials: L
authors.lastname: Armbruster
authors.forename: Rainer
authors.initials: R
authors.lastname: Linke
authors.forename: Friedrich
authors.initials: F
authors.lastname: Schumm
authors.forename: Raymond
authors.initials: R
authors.lastname: Voltz
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D019788:Fluorodeoxyglucose F18; D005858:Germany; D006801:Humans; D015624:Lambert-Eaton Myasthenic Syndrome / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010751:Phosphopyruvate Hydratase / Q000378:metabolism; D049268:Positron-Emission Tomography / Q000379:methods; D055815:Young Adult
chemical_list: D019788:Fluorodeoxyglucose F18; D010751:Phosphopyruvate Hydratase