title: The burden of hospitalizations and clinic visits for rotavirus disease in children aged <5 years in the Philippines.
abstract: BACKGROUND
  Recent data on the burden of hospitalization and clinic visits for rotavirus gastroenteritis are needed to support the decision to introduce rotavirus vaccine in the Philippines.
  
  
  METHODS
  From 2005 through 2006, children aged <5 years with acute diarrhea who attended 1 of 7 clinics and/or hospitals in Muntinlupa City, the Philippines, were enrolled. Clinical and demographic data were collected, and a stool specimen was obtained for rotavirus testing and typing for G and P antigens. The incidences of different clinical outcomes of rotavirus gastroenteritis were determined for 3 townships under surveillance and were extrapolated to the Philippines with use of national data sets.
  
  
  RESULTS
  The prevalence of rotavirus was 31% (171/560) among children hospitalized with diarrhea, 30% (155/520) among those who presented to the emergency department, and 15% (56/385) among those who presented to a clinic. The annual estimated incidence (per 100,000 children aged <5 years) of rotavirus gastroenteritis in outpatient, emergency department, and inpatient settings was 755, 451, and 279, respectively. Of 274 strains, 50 (18%) were nontypeable. Of the 128 strains that underwent G and P typing, 98% belong to the globally common strains G3P[P], G2P[4], and G1P[8].
  
  
  CONCLUSIONS
  The burden of rotavirus gastroenteritis in the Philippines is high and is predominantly caused by strains against which current vaccines have shown good efficacy, suggesting that routine immunization will have a large impact on rotavirus disease burden.
authors.affiliation: Antimicrobial Resistance Surveillance Reference Laboratory, Philippines.
authors.forename: Celia C
authors.initials: CC
authors.lastname: Carlos
authors.forename: Marianette T
authors.initials: MT
authors.lastname: Inobaya
authors.forename: Joseph S
authors.initials: JS
authors.lastname: Bresee
authors.forename: Marietta L
authors.initials: ML
authors.lastname: Lagrada
authors.forename: Agnettah M
authors.initials: AM
authors.lastname: Olorosa
authors.forename: Carl D
authors.initials: CD
authors.lastname: Kirkwood
authors.forename: Marc-Alain
authors.initials: MA
authors.lastname: Widdowson
mesh_terms: D002675:Child, Preschool; D017281:Cost of Illness; D005759:Gastroenteritis / Q000453:epidemiology; D005838:Genotype; D006760:Hospitalization; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D010679:Philippines / Q000453:epidemiology; D012401:Rotavirus / Q000145:classification; D012400:Rotavirus Infections / Q000453:epidemiology* / Q000821:virology