Exfoliation syndrome in the Reykjavik Eye Study: risk factors for baseline prevalence and 5-year incidence.
OBJECTIVE
To examine the age- and gender-specific prevalent and 5-year incident risk of developing exfoliation syndrome (XFS).


METHODS
In a population-based random sample of citizens 50 years and older, 1045 persons had baseline examination in 1996; 846 of the 958 survivors (88.2%) had a follow-up examination in 2001. Following maximum dilatation of pupils, a diagnosis of exfoliation was established on slit-lamp examination. An extensive questionnaire was administered at baseline and follow-up. Prevalent and incident risk was then calculated using a multivariate analysis.


RESULTS
The following variables were found to correlate significantly with prevalence risk of XFS at baseline: age, female gender, increased iris pigmentation, moderate use of alcohol and self-reported asthma. We also found that, compared with those who consumed dietary fibre-rich vegetables, green or yellow vegetables, and fruit less than once a month in their 20s and 40s, those consuming the same food items once or twice every 2 weeks were found to be less likely to have XFS. The same applied to those consuming dietary fibre rich once or twice every 2 weeks in their 40s and 60s.


CONCLUSIONS
Food items that are possibly surrogates for antioxidative effect may correlate with decreased risk of XFS and increased iris pigmentation may correlate with increased risk. Given the large number of comparisons, these findings require validation through additional clinical studies. Increased age and female gender increase the likelihood of XFS.
Arnarsson
Arsaell
A
Department of Ophthalmology, Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Jonasson
Fridbert
F
Damji
Karim F
KF
Gottfredsdottir
Maria S
MS
Sverrisson
Thordur
T
Sasaki
Hiroshi
H
D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001249:Asthma / Q000150:complications / Q000453:epidemiology; D004032:Diet / Q000009:adverse effects / Q000706:statistics & numerical data; D004812:Epidemiologic Methods; D017889:Exfoliation Syndrome / Q000453:epidemiology* / Q000209:etiology; D005127:Eye Color; D005260:Female; D005638:Fruit; D006801:Humans; D007055:Iceland / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012737:Sex Factors; D014675:Vegetables