title: NeoPHOX--an easily accessible P,N-ligand for iridium-catalyzed asymmetric hydrogenation: preparation, scope and application in the synthesis of demethyl methoxycalamenene.
abstract: Using a new class of chiral iridium hydrogenation catalysts, the antitumor natural product demethyl calamenene was synthesized in four steps in >20% overall yield and high enantiomeric purity.
authors.affiliation: Department of Chemistry, University of Basel, St. Johanns-Ring 19, CH-4056 Basel, Switzerland.
authors.forename: Marcus G
authors.initials: MG
authors.lastname: Schrems
authors.forename: Andreas
authors.initials: A
authors.lastname: Pfaltz
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D002384:Catalysis; D006865:Hydrogenation; D007495:Iridium / Q000737:chemistry*; D008024:Ligands; D013729:Terpenes / Q000138:chemical synthesis*
chemical_list: D000970:Antineoplastic Agents; D008024:Ligands; D013729:Terpenes; C546737:demethyl methoxycalamenene; D007495:Iridium