The catalytic asymmetric addition of alkyl- and aryl-zinc reagents to an isoxazole aldehyde.
Nucleophilic addition of alkyl- and aryl zinc reagents to a C(4) functionalized isoxazolyl aldehyde proceeded effectively with high enantioselectivity (85-94% e.e.). The amino alcohol catalyst (S)-2-piperidinyl-1,1,2-triphenyl ethanol (10) afforded the (R)-product 2b, as established by x-ray crystallography.
Nelson
Jared K
JK
Department of Chemistry, University of Idaho, Moscow ID 83844-2343 USA.
Twamley
Brendan
B
Villalobos
Trinidad J
TJ
Natale
Nicholas R
NR