title: Cholangiolocellular carcinoma of the liver: imaging findings.
abstract: OBJECTIVE
  Cholangiolocellular carcinoma (CLC) is a rare subtype of intrahepatic cholangiocarcinoma as categorized according to the World Health Organization criteria. Recent study also revealed that CLC would originate from hepatic progenitor cells, which are liver-specific stem cells. We reviewed the imaging findings of CLCs, including those of intrahepatic metastases.
  
  
  METHODS
  Eight patients who underwent partial hepatectomy were included in this study. Images, including dynamic computed tomographic and magnetic resonance images, were reviewed.
  
  
  RESULTS
  On arterial phase images, the lesions appeared as masses exhibiting early and complete enhancement or predominantly peripheral enhancement. Retention of the contrast media in the lesions was observed in half of the lesions. The metastatic nodules had indistinct borders and showed early enhancement along with delayed central enhancement.
  
  
  CONCLUSIONS
  Although CLC with dense central fibrosis exhibits imaging features similar to those exhibited by intrahepatic cholangiocarcinoma, early enhancement in most lesions with persistent delayed enhancement is one of the characteristic imaging findings of this rare tumor.
authors.affiliation: Department of Pathology, Saitama Medical, University, International Medical Center, 137-1 Yamane, Hidaka-shi,Saitama-ken 350-1298, Japan. utaroh-motosugi@nifty.com
authors.forename: Utaroh
authors.initials: U
authors.lastname: Motosugi
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Ichikawa
authors.forename: Hiroto
authors.initials: H
authors.lastname: Nakajima
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Araki
authors.forename: Masanori
authors.initials: M
authors.lastname: Matsuda
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Suzuki
authors.forename: Hideki
authors.initials: H
authors.lastname: Fujii
authors.forename: Tadao
authors.initials: T
authors.lastname: Nakazawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yamaguchi
mesh_terms: D000368:Aged; D018281:Cholangiocarcinoma / Q000175:diagnosis* / Q000473:pathology / Q000556:secondary / Q000601:surgery; D005260:Female; D006801:Humans; D007089:Image Enhancement; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000556:secondary / Q000601:surgery; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011172:Portography; D014057:Tomography, X-Ray Computed