title: Acquisition of high-level mupirocin resistance and its fitness cost among methicillin-resistant Staphylococcus aureus strains with low-level mupirocin resistance.
abstract: We investigated whether methicillin (meticillin)-resistant Staphylococcus aureus (MRSA) isolates with low-level mupirocin resistance can serve as recipients of a pSK41-like plasmid conferring high-level mupirocin resistance without substantial fitness cost. Our results suggest that acquisition of the plasmid conferring high-level mupirocin resistance was not necessarily associated with fitness cost in some MRSA recipients with low-level mupirocin resistance.
authors.affiliation: Department of Pediatrics, Division of Pediatric Infectious Diseases, University of Illinois College of Medicine at Peoria,, Ilinois 61637, USA. kmongkol@uic.edu
authors.forename: Kanokporn
authors.initials: K
authors.lastname: Mongkolrattanothai
authors.forename: Lisa
authors.initials: L
authors.lastname: Pumfrey
authors.forename: Peggy
authors.initials: P
authors.lastname: Mankin
authors.forename: Barry M
authors.initials: BM
authors.lastname: Gray
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics*; D003227:Conjugation, Genetic; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D006801:Humans; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects* / Q000235:genetics / Q000254:growth & development; D008826:Microbial Sensitivity Tests; D016712:Mupirocin / Q000494:pharmacology*; D010957:Plasmids; D013203:Staphylococcal Infections / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D016712:Mupirocin