Propionibacterium acnes and sebaceous lipogenesis: a love-hate relationship?
In this issue, Iinuma et al. show that Propionibacterium acnes (P. acnes)-conditioned medium and formalin-killed P. acnes augment intracellular lipid formation in hamster sebocytes by increasing the de novo synthesis of triacylglycerols. This commentary summarizes the current knowledge of the association of P. acnes with sebaceous lipogenesis, inflammation, and innate immunity, and points out the concurrent evidence that P. acnes-induced lipids may represent a recruitment of allies and/or enemies of the human skin.
Zouboulis
Christos C
CC
Departments of Dermatology, Venereology, Allergology, and Immunology, Dessau Medical Center, Dessau, Germany.
D000152:Acne Vulgaris / Q000209:etiology; D000818:Animals; D003346:Corticotropin-Releasing Hormone / Q000502:physiology; D006224:Cricetinae; D004268:DNA-Binding Proteins / Q000502:physiology; D007113:Immunity, Innate; D007249:Inflammation / Q000209:etiology; D050155:Lipogenesis; D000071518:Liver X Receptors; D057093:Orphan Nuclear Receptors; D011425:Propionibacterium acnes / Q000472:pathogenicity*; D018160:Receptors, Cytoplasmic and Nuclear / Q000502:physiology; D012627:Sebaceous Glands / Q000378:metabolism*; D051195:Toll-Like Receptor 2 / Q000502:physiology
D004268:DNA-Binding Proteins; D000071518:Liver X Receptors; D057093:Orphan Nuclear Receptors; D018160:Receptors, Cytoplasmic and Nuclear; D051195:Toll-Like Receptor 2; D003346:Corticotropin-Releasing Hormone