title: Fibrin sealant (Tisseel) for hiatal mesh fixation in an experimental model in pigs.
abstract: BACKGROUND
  This study was designed to assess the efficacy of the fibrin sealant fixation of titanized polypropylene mesh in experimental hiatal mesh closure in pigs. Prosthetic hiatal closure is recommended for the repair of large hiatal/paraesophageal hernias as well as for antireflux surgery. However, only limited data exist on the favorable choice of meshes and fixation devices. Migration of the implant and trauma to neighboring organs due to perforating devices, such as sutures or tacks, present potentially lethal complications. In this study, we propose the fixation of titanized polypropylene meshes (TS) specifically developed for hiatal closure (TISure; GfE Medizintechnik GmbH, Nuremberg, Germany) with human fibrin sealant (FS, Tisseel; Baxter Biosciences, Vienna, Austria).
  
  
  METHODS
  A laparotomy was carried out in 7 mini-pigs (27-30 kg bodyweight) under general anaesthesia, and a TS was implanted after precise dissection of the right and left crura and the crural commissure. The key hole of the TS was placed around the esophagus at the gastroesophageal junction. One mL of FS was applied with the Easy Spray system (Baxter Biosciences, Vienna, Austria) for circular and three dimensional mesh fixation onto the diaphragm. Due to the lack of accepted gold standards of hiatal mesh reinforcement, no control group was used. Animals were sacrificed after 4 wk, and meshes were explanted after macroscopical assessment of the correct position and tissue integration. Histology was performed.
  
  
  RESULTS
  All meshes showed excellent tissue integration and no signs of migration or dislocation. FS was completely degraded and replaced by well vascularized fibroblastic tissue.
  
  
  CONCLUSIONS
  Titanized polypropylene mesh with FS fixation was found to be a safe and efficient combination for reinforcement of the hiatal closure in this preliminary experimental model.
authors.affiliation: Ludwig Boltzmann Institute for Experimental and Clinical Traumatology and Cluster for Tissue Regeneration, Vienna, Austria.
authors.forename: René H
authors.initials: RH
authors.lastname: Fortelny
authors.forename: Alexander H
authors.initials: AH
authors.lastname: Petter-Puchner
authors.forename: Karl S
authors.initials: KS
authors.lastname: Glaser
authors.forename: Claudia
authors.initials: C
authors.lastname: Keibl
authors.forename: Simone
authors.initials: S
authors.lastname: Gruber-Blum
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Ohlinger
authors.forename: Heinz
authors.initials: H
authors.lastname: Redl
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use*; D005548:Foreign-Body Migration / Q000517:prevention & control*; D006551:Hernia, Hiatal / Q000601:surgery*; D006801:Humans; D011126:Polypropylenes / Q000627:therapeutic use; D013526:Surgical Mesh / Q000009:adverse effects*; D013552:Swine; D013556:Swine, Miniature; D000267:Tissue Adhesions / Q000209:etiology
chemical_list: D015718:Fibrin Tissue Adhesive; D011126:Polypropylenes