Solid-phase synthesis of homodimeric peptides: preparation of covalently-linked dimers of amyloid beta peptide.
Covalently cross-linked homodimeric Abeta peptides have been prepared by solid-phase peptide synthesis by exploiting 'site-site interactions', and exhibit substantially increased oligomerisation and fibrillisation properties compared with the corresponding monomers.
Kok
W Mei
WM
School of Chemistry, The University of Melbourne, Parkville, VIC 3010, Australia.
Scanlon
Denis B
DB
Karas
John A
JA
Miles
Luke A
LA
Tew
Deborah J
DJ
Parker
Michael W
MW
Barnham
Kevin J
KJ
Hutton
Craig A
CA
D000595:Amino Acid Sequence; D016229:Amyloid beta-Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D003432:Cross-Linking Reagents; D008969:Molecular Sequence Data; D055503:Protein Multimerization
D016229:Amyloid beta-Peptides; D003432:Cross-Linking Reagents