Effect of temporal difficulty on cerebrocerebellar interaction during visual duration discrimination.
The cerebellum has been demonstrated to be involved in various tasks requiring sensory discrimination, both for temporal and non-temporal events; however, little is known about the characteristic of its involvement. In this study, a visual duration discrimination task with various levels of temporal difficulty was examined to investigate the cerebrocerebellar interaction using event-related functional magnetic resonance imaging (MRI). The cerebrocerebellar interaction analysis revealed that the cerebellum increased its activity in response to increasing temporal difficulty whereas the frontal cortex only increased its connective strength with the cerebellum but did not increase activity when the discrimination of temporal events was more difficult. The present findings support the view that better sensory information is provided by the cerebellum, which in turn may boost the efficiency of cortical computation for sensory discrimination.
Shih
Lynn Y L
LY
Institute of Neuroscience, School of Life Science, National Yang-Ming University, No. 155 Section 2 Linong Street, Shih-Pai, Taipei, Taiwan.
Yeh
Tzu-Chen
TC
Kuo
Wen-Jui
WJ
Tzeng
Ovid J L
OJ
Hsieh
Jen-Chuen
JC
D000328:Adult; D000704:Analysis of Variance; D001931:Brain Mapping; D002531:Cerebellum / Q000502:physiology*; D002540:Cerebral Cortex / Q000502:physiology*; D004192:Discrimination, Psychological / Q000502:physiology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D009434:Neural Pathways / Q000502:physiology; D010775:Photic Stimulation; D011597:Psychomotor Performance / Q000502:physiology; D011930:Reaction Time / Q000502:physiology; D013998:Time Perception / Q000502:physiology*; D014796:Visual Perception / Q000502:physiology*