title: Synthesis and biological activity of dialkylphosphocholines.
abstract: A series of dialkylphosphocholines were prepared and evaluated for their biological activity. The antiprotozoal activity was determined against Acanthamoeba lugdunensis. Compound 15 exhibited excellent trophocidal activity. None of the tested dialkylphosphocholines exhibited better fungicidal activity against Candida albicans than miltefosine. The antineoplastic activity was determined against HeLa. The most cytotoxic was compound 10, which was more active against tumor cells as against normal cells.
authors.affiliation: Department of Chemical Theory of Drugs, Faculty of Pharmacy, Comenius University, Kalinciakova 8, 83232 Bratislava, Slovakia. lukac@fpharm.uniba.sk
authors.forename: Milos
authors.initials: M
authors.lastname: Lukác
authors.forename: Martin
authors.initials: M
authors.lastname: Mrva
authors.forename: Eva
authors.initials: E
authors.lastname: Fischer-Fodor
authors.forename: Ivan
authors.initials: I
authors.lastname: Lacko
authors.forename: Marián
authors.initials: M
authors.lastname: Bukovský
authors.forename: Natalia
authors.initials: N
authors.lastname: Miklásová
authors.forename: Frantisek
authors.initials: F
authors.lastname: Ondriska
authors.forename: Ferdinand
authors.initials: F
authors.lastname: Devínsky
mesh_terms: D000048:Acanthamoeba; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000494:pharmacology*; D000981:Antiprotozoal Agents; D002176:Candida albicans / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D020128:Inhibitory Concentration 50; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010767:Phosphorylcholine / Q000031:analogs & derivatives; D010936:Plant Extracts; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000970:Antineoplastic Agents; D000981:Antiprotozoal Agents; D010936:Plant Extracts; D010767:Phosphorylcholine; C039128:miltefosine