title: Risk factors for cerebral venous thrombosis and deep venous thrombosis in patients aged between 15 and 50 years.
abstract: Cerebral venous thrombosis (CVT) and deep vein thrombosis or pulmonary embolism (DVT/PE) are associated with many risk factors. It is unclear why CVT occurs less often than DVT/PE. Age dependent risk factors may play a role. The aim of our study was to compare risk factors in a uniform age group of CVT and DVT/PE patients aged between 15 and 50 years. Thrombophilic markers and clinical risk factors of 79 CVT patients and 173 DVT/PE patients aged 15-50 years were compared. Multivariable logistic regression analysis was performed to investigate if risk factors were independently associated with CVT or DVT/PE. Cerebral venous thrombosis patients were younger (median age 30 years vs. 42 years; p<0.001) and more often female (82% vs. 52%; p<0.001). There were no differences in thrombophilic markers. Cerebral venous thrombosis was less often associated with trauma, immobilisation or surgery than DVT/PE (6% vs. 21%; adjusted OR 0.29; 95%CI 0.10-0.82). In women, CVT was more frequently associated with oral contraceptive use, pregnancy or puerperium (82% vs. 53%; adjusted OR 2.34; 95%CI 1.03-5.32). This study demonstrated no differences in thrombophilic markers between CVT patients and DVT/PE patients aged between 15 and 50 years, while the frequency of some transient risk factors was different. Cerebral venous thrombosis was relatively more common in women and hormonal factors may predispose to CVT compared to DVT/PE, while trauma, immobilisation and surgery may be less important in the pathophysiology of CVT.
authors.affiliation: Department of Neurology, University Medical Centre Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands. k.koopman@neuro.umcg.nl
authors.forename: Karen
authors.initials: K
authors.lastname: Koopman
authors.forename: Maarten
authors.initials: M
authors.lastname: Uyttenboogaart
authors.forename: Patrick C A J
authors.initials: PC
authors.lastname: Vroomen
authors.forename: Jan
authors.initials: J
authors.lastname: van der Meer
authors.forename: Jacques
authors.initials: J
authors.lastname: De Keyser
authors.forename: Gert-Jan
authors.initials: GJ
authors.lastname: Luijckx
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D003278:Contraceptives, Oral, Hormonal / Q000009:adverse effects; D004198:Disease Susceptibility; D005260:Female; D012739:Gonadal Steroid Hormones / Q000378:metabolism*; D006801:Humans; D020767:Intracranial Thrombosis / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011247:Pregnancy; D012307:Risk Factors; D012737:Sex Factors; D020246:Venous Thrombosis / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology / Q000503:physiopathology
chemical_list: D003278:Contraceptives, Oral, Hormonal; D012739:Gonadal Steroid Hormones