title: In vitro antimicrobial activity of several concentrations of NaOCl and Octenisept in elimination of endodontic pathogens.
abstract: OBJECTIVE
  The objective of this study was to test and compare the in vitro effectiveness of sodium hypochlorite (NaOCl), and octenidine hydrochloride (Octenisept) at different concentrations in the elimination of resistant microorganisms including S. aureus, E. faecalis, and C. albicans over a range of time intervals.
  
  
  METHODS
  A broth dilution test was performed, and the timing for irrigants to kill microbial cells was recorded. Then the samples were compared by using Kruskal-Wallis test, with significance level at P less than .05. Also minimum inhibitory concentration (MIC) of Octenisept was evaluated.
  
  
  RESULTS
  The in vitro antimicrobial effect of the most effective concentrations of the tested irrigants were ranked from strongest to weakest as follows: 100% Octenisept, 50% Octenisept, 5.25 % NaOCl, and 2.5 % NaOCl.
  
  
  CONCLUSIONS
  The antimicrobial action is related to type and concentration of the irrigants as well as the microbial susceptibility.
authors.affiliation: Department of Pediatric Dentistry, Faculty of Dentistry, University of Gazi, Ankara, Turkey. ebru_aktepe@hotmail.com
authors.forename: Resmiye Ebru
authors.initials: RE
authors.lastname: Tirali
authors.forename: Yeşim
authors.initials: Y
authors.lastname: Turan
authors.forename: Neşe
authors.initials: N
authors.lastname: Akal
authors.forename: Zeynep Ceren
authors.initials: ZC
authors.lastname: Karahan
mesh_terms: D000891:Anti-Infective Agents, Local / Q000008:administration & dosage / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects; D015169:Colony Count, Microbial; D003786:Dental Pulp Cavity / Q000382:microbiology; D004305:Dose-Response Relationship, Drug; D013293:Enterococcus faecalis / Q000187:drug effects; D007097:Imines; D007201:Indicator Dilution Techniques; D008826:Microbial Sensitivity Tests; D050296:Microbial Viability / Q000187:drug effects; D011725:Pyridines / Q000008:administration & dosage / Q000494:pharmacology*; D012388:Root Canal Irrigants / Q000008:administration & dosage / Q000494:pharmacology*; D012973:Sodium Hypochlorite / Q000008:administration & dosage / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000891:Anti-Infective Agents, Local; D007097:Imines; D011725:Pyridines; D012388:Root Canal Irrigants; D012973:Sodium Hypochlorite; C034213:octenidine