Haplotype-based case-control study of the human AGTR1 gene and essential hypertension in Han Chinese subjects.
OBJECTIVE
Essential hypertension is considered to be a multifactorial trait resulting from the combined influence of environmental and genetic determinants. The aim of the study is to assess the association between the human AGTR1 gene and essential hypertension (EH) using a haplotype-based case-control study in Han Chinese subjects.


METHODS
Seven tag SNPs and the A1166C polymorphism of the AGTR1 gene were genotyped in 510 hypertension subjects and 510 normotensive subjects using PCR-RFLP method.


RESULTS
Single SNP analyses indicated that the rs12695895 was significantly associated with hypertension, adjusted for covariates. Compared with the other haplotypes, Hap4 (AGGACTT) which carry the susceptible rs12695895 A allele was found to significantly increase the risk of EH with odds ratios equal to 1.84 (p=0.0002).


CONCLUSIONS
The present results indicate that rs12695895 might be a genetic marker for EH and Hap4 (AGGACTT) was associated with hypertension in Han Chinese population.
Nie
Sheng-jie
SJ
Human Genetics Center of Yunnan University, #2 N. Cuihu Rd. Kunming, Yunnan 650091 PR China.
Wen-ru
Tang
T
Bi-feng
Chen
C
Jin
Li
L
Wen
Zhang
Z
Sheng-jun
Luo
L
Wei-wei
Li
L
Hai-jing
Yu
Y
Chun-jie
Xiao
X
D000328:Adult; D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D001794:Blood Pressure / Q000235:genetics / Q000502:physiology; D016022:Case-Control Studies; D005260:Female; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D044140:Receptor, Angiotensin, Type 1 / Q000235:genetics*
D005819:Genetic Markers; D044140:Receptor, Angiotensin, Type 1