Preparation of 4-aminophenylacetic acid derivatives with promising antimicrobial activity.
Condensation of 4-aminophenylacetic acid with phthalic anhydride gave (dioxoisoindolin-2-yl)phenylacetic acid (1), which was employed as the key intermediate in the synthesis of title compounds 2-8. The products were characterized by analytical and spectral data (IR, 1H NMR, 13C NMR and mass spectra). Antimicrobial activities were studied and some of the compounds showed promising results.
Bedair
Ahmed H
AH
Department of Chemistry, Faculty of Science, Al-Azhar University, Nasr City 11884, Cairo, Egypt. Bedair_AH@yahoo.com
Ali
Fawzy M
FM
El-Agrody
Ahmed M
AM
Eid
Fathy A
FA
El-Nassag
Mohammed A A
MA
El-Sherbeny
Gamal
G
D000814:Aniline Compounds / Q000138:chemical synthesis / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D052978:Disk Diffusion Antimicrobial Tests; D005658:Fungi / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D010648:Phenylacetates / Q000138:chemical synthesis / Q000494:pharmacology*; D013057:Spectrum Analysis
D000814:Aniline Compounds; D000890:Anti-Infective Agents; D010648:Phenylacetates; C109911:4-aminophenylacetic acid