title: A general electrochemical method for label-free screening of protein-small molecule interactions.
abstract: Here we report a versatile method by which the interaction between a protein and a small molecule, and the disruption of that interaction by competition with other small molecules, can be monitored electrochemically directly in complex sample matrices.
authors.affiliation: Department of Chemical Engineering, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.
authors.forename: Kevin J
authors.initials: KJ
authors.lastname: Cash
authors.forename: Francesco
authors.initials: F
authors.lastname: Ricci
authors.forename: Kevin W
authors.initials: KW
authors.lastname: Plaxco
mesh_terms: D015374:Biosensing Techniques / Q000379:methods*; D004247:DNA / Q000737:chemistry; D004563:Electrochemistry / Q000379:methods*; D011485:Protein Binding; D025941:Protein Interaction Mapping / Q000379:methods*; D011506:Proteins / Q000378:metabolism*; D054852:Small Molecule Libraries / Q000032:analysis* / Q000378:metabolism
chemical_list: D011506:Proteins; D054852:Small Molecule Libraries; D004247:DNA