Enantioselective copper-catalyzed reductive Michael cyclizations.
In the presence of siloxanes as stoichiometric reductants, chiral copper-bisphosphine complexes catalyze highly enantioselective reductive Michael cyclizations of substrates containing two alpha,beta-unsaturated carbonyl moieties. The diastereochemical outcome of these reactions is dependent upon whether biaryl- or ferrocene-based chiral bisphosphines are employed.
Oswald
Claire L
CL
School of Chemistry, University of Edinburgh, The King's Buildings, West Mains Road, Edinburgh, EH9 3JJ, United Kingdom.
Peterson
Justine A
JA
Lam
Hon Wai
HW