title: Comment on "The Arabidopsis circadian clock incorporates a cADPR-based feedback loop".
abstract: Dodd et al. (Reports, 14 December 2007, p. 1789) reported that the Arabidopsis circadian clock incorporates the signaling molecule cyclic adenosine diphosphate ribose (cADPR). In contrast, we found that there is no rhythm of cADPR levels nor are there any significant effects on the rhythm by cADPR overexpression, thus raising questions about the conclusions of Dodd et al.
authors.affiliation: Department of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Xu
authors.forename: Richard
authors.initials: R
authors.lastname: Graeff
authors.forename: Qiguang
authors.initials: Q
authors.lastname: Xie
authors.forename: Karen L
authors.initials: KL
authors.lastname: Gamble
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Mori
authors.forename: Carl Hirschie
authors.initials: CH
authors.lastname: Johnson
mesh_terms: D036541:ADP-ribosyl Cyclase / Q000378:metabolism; D017360:Arabidopsis / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D002118:Calcium / Q000378:metabolism*; D002940:Circadian Rhythm; D036563:Cyclic ADP-Ribose / Q000378:metabolism*; D004958:Estradiol / Q000494:pharmacology; D025461:Feedback, Physiological; D009536:Niacinamide / Q000494:pharmacology
chemical_list: D036563:Cyclic ADP-Ribose; D009536:Niacinamide; D004958:Estradiol; D036541:ADP-ribosyl Cyclase; D002118:Calcium