Neutralizing inter-clade cross-reactivity of HIV-1  V1/V2-specific secretory immunoglobulin A in  Colombian and French cohorts.
Neutralizing activity of secretory immunoglobulin A (S-IgA) directed against the V1/V2 domain of HIV-1 was studied in parotid saliva of HIV-1- infected patients in Colombian and French cohorts. Purified V1/V2-specific S-IgA antibodies were found to neutralize clades A, B and C primary isolates in five out 76 and 82 patients from each cohort, respectively. These results suggest that neutralizing S-IgA antibodies targeting the V1/V2 domain may provide protection against HIV-1 infection in vivo and may be beneficial in mucosal vaccines.
Granados-Gonzalez
Viviana
V
Groupe Immunité des Muqueuses et Agents Pathogènes, EA 3064, Université de Saint Etienne, Saint Etienne, France.
Piedrahita
Leidy Diana
LD
Martinez-Gutierrez
Marlen
M
Lawrence
Philip
P
Saoudin
Henia
H
Zapata
Ximena
X
Lucht
Frederic
F
Pinter
Abraham
A
Genin
Christian
C
Urcuqui-Inchima
Silvio
S
Riffard
Serge
S
D057134:Antibodies, Neutralizing / Q000276:immunology*; D015331:Cohort Studies; D003105:Colombia; D005260:Female; D005602:France; D015699:HIV Envelope Protein gp120 / Q000276:immunology; D015658:HIV Infections / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000276:immunology*; D008297:Male; D010446:Peptide Fragments / Q000276:immunology; D012463:Saliva / Q000276:immunology* / Q000821:virology
D057134:Antibodies, Neutralizing; D015699:HIV Envelope Protein gp120; C059761:HIV envelope protein gp120 (135-148); D007071:Immunoglobulin A, Secretory; D010446:Peptide Fragments