A direct approach to 5-hydroxybenzofurans via a platinum-catalyzed domino rearrangement/5-endo-dig cyclization reaction of quinols.
A highly efficient and atom-economical construction of 2-substituted 5-hydroxybenzofurans was accomplished by employing a platinum-catalyzed domino dienone-phenol rearrangement/5-endo-dig cyclization reaction of quinols bearing alkynes.
Kim
Ikyon
I
Medicinal Chemistry Research Center, Korea Research Institute of Chemical Technology, Daejeon 305-600, Republic of Korea. ikyon@krict.re.kr
Kim
Kyungsun
K
Choi
Jungeun
J
D001572:Benzofurans / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D006873:Hydroquinones / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D010984:Platinum / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization
D001572:Benzofurans; D006873:Hydroquinones; D010984:Platinum