The pilot phase of the NIH Chemical Genomics Center.
The NIH Chemical Genomics Center (NCGC) was the inaugural center of the Molecular Libraries and Screening Center Network (MLSCN). Along with the nine other research centers of the MLSCN, the NCGC was established with a primary goal of bringing industrial technology and experience to empower the scientific community with small molecule compounds for use in their research. We intend this review to serve as 1) an introduction to the NCGC standard operating procedures, 2) an overview of several of the lessons learned during the pilot phase and 3) a review of several of the innovative discoveries reported during the pilot phase of the MLSCN.
Thomas
Craig J
CJ
NIH Chemical Genomics Center, NHGRI, National Institutes of Health, 9800 Medical Center Drive, Building B, Room 3005, MSC: 3370, Bethesda, MD 20892-3370, USA. craigt@nhgri.nih.gov
Auld
Douglas S
DS
Huang
Ruili
R
Huang
Wenwei
W
Jadhav
Ajit
A
Johnson
Ronald L
RL
Leister
William
W
Maloney
David J
DJ
Marugan
Juan J
JJ
Michael
Sam
S
Simeonov
Anton
A
Southall
Noel
N
Xia
Menghang
M
Zheng
Wei
W
Inglese
James
J
Austin
Christopher P
CP
D002626:Chemistry, Pharmaceutical; D004353:Drug Evaluation, Preclinical; D023281:Genomics; D057166:High-Throughput Screening Assays; D009316:National Institutes of Health (U.S.); D010865:Pilot Projects; D054852:Small Molecule Libraries; D014481:United States
D054852:Small Molecule Libraries