title: Evaluation and implications of natural product use in preoperative patients: a retrospective review.
abstract: BACKGROUND
  Medication Reconciliation and Medication Safety are two themes emphasized in a variety of healthcare organizations. As a result, health care facilities have established methods for obtaining a patient's medication history. However, these methods may vary among institutions or even among the health care professionals in a single institution, and studies have shown that patients are reluctant to disclose their complementary and alternative medicine use to any health care professional. This lack of disclosure is important in surgical patients because of potential herbal interactions with medications and drugs used during the surgical procedure; and the potential for adverse reactions including effects on coagulation, blood pressure, sedation, electrolytes or diuresis. Therefore, the objectives of this study are to identify patterns of natural product use, to identify potential complications among patients scheduled for surgery, to improve existing medication reconciliation efforts, and to develop discontinuation guidelines for the use of these products prior to surgery.
  
  
  METHODS
  A retrospective review of surgery patients presenting to the Anesthesia Preoperative Evaluation Clinic (APEC) at the University of Kansas Hospital was conducted to identify the prevalence of natural product use. The following data was collected: patient age; gender; allergy information; date of medication history; number of days prior to surgery; source of medication history; credentials of person obtaining the history; number and name of prescription medications, over-the-counter medications and natural products; and natural product dosage. Following the collection of data and analysis of the most common natural products used, possible complications and interactions were identified, and a protocol regarding the pre-operative use of natural products was developed and implemented.
  
  
  RESULTS
  Approximately one-fourth of patients seen in the APEC indicated the use of natural products. Patients taking natural products were significantly older, were more likely to undergo cardiac or chest surgery, and were more likely to be taking more prescription and non-prescription medications (all p < 0.001).
  
  
  CONCLUSIONS
  Based on the results of this study, it is concluded that there is a need for established guidelines regarding discontinuation of selected natural products prior to surgery and further education is needed concerning the perioperative implications of natural products.
authors.affiliation: University of Kansas Drug Information Center, 3901 Rainbow Boulevard, MS 4040, Kansas City, Kansas 66160, USA. aking2@kumc.edu
authors.forename: Allison R
authors.initials: AR
authors.lastname: King
authors.forename: Flint S
authors.initials: FS
authors.lastname: Russett
authors.forename: Joyce A
authors.initials: JA
authors.lastname: Generali
authors.forename: Dennis W
authors.initials: DW
authors.lastname: Grauer
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000529:Complementary Therapies / Q000706:statistics & numerical data*; D005260:Female; D041743:Herb-Drug Interactions; D006801:Humans; D007615:Kansas; D008297:Male; D008499:Medical Records; D008875:Middle Aged; D008517:Phytotherapy / Q000706:statistics & numerical data*; D028321:Plant Preparations / Q000008:administration & dosage*; D011300:Preoperative Care; D012189:Retrospective Studies; D012650:Self Disclosure; D019616:Thoracic Surgical Procedures
chemical_list: D028321:Plant Preparations