HIV fusion inhibitors.
Drugs based on amino acid sequence of Heptad Repeats of gp41 of HIV have been explored in search of anti-HIV drugs acting by inhibition of the gp41 6-helix formation and subsequent cellular infection. These are classified under a distinct discipline called HIV fusion inhibitors. Resistance to HIV fusion inhibitors and their solutions have also been discussed in this review.
Qadir
M I
MI
College of Pharmacy, GC University, Faisalabad, Pakistan. mrimranqadir@hotmail.com
Malik
S A
SA
D000595:Amino Acid Sequence; D024882:Drug Resistance, Viral; D006678:HIV / Q000187:drug effects / Q000502:physiology; D015700:HIV Envelope Protein gp41 / Q000037:antagonists & inhibitors / Q000235:genetics; D023581:HIV Fusion Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D008561:Membrane Fusion / Q000187:drug effects; D008969:Molecular Sequence Data
D015700:HIV Envelope Protein gp41; D023581:HIV Fusion Inhibitors