Synthesis and anticancer activity of novel amide derivatives of non-acetal deoxoartemisinin.
Novel amide derivatives of C-12 non-acetal deoxoartemisinin were synthesized. Some of the derivatives had potent in vitro anticancer activity against major human cancer cell lines. The deoxoartemisinin amide trimer had potent in vivo antiangiogenic activity, according to the mouse matrigel plug assay.
Jung
Mankil
M
Department of Chemistry, Yonsei University, Seoul 120-749, Republic of Korea. mjung@yonsei.ac.kr
Park
Namsoo
N
Moon
Hyung-In
HI
Lee
Yongnam
Y
Chung
Won-Yoon
WY
Park
Kwang-Kyun
KK
D000080:Acetals / Q000737:chemistry; D000577:Amides / Q000138:chemical synthesis / Q000737:chemistry*; D000818:Animals; D017209:Apoptosis / Q000187:drug effects / Q000502:physiology; D037621:Artemisinins / Q000138:chemical synthesis* / Q000737:chemistry; D049109:Cell Proliferation; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D004730:Endothelium, Vascular / Q000187:drug effects / Q000473:pathology; D006801:Humans; D020128:Inhibitory Concentration 50; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D013329:Structure-Activity Relationship
D000080:Acetals; D000577:Amides; D037621:Artemisinins; C063801:deoxoartemisinin