Histopathology of non-alcoholic fatty liver disease.
Current imaging methodologies can detect steatosis with increasing accuracy but cannot detect inflammation or pre-cirrhotic fibrosis or remodeling of the liver parenchyma. Imaging also cannot assess types or localization of hepatic steatosis. With the increased use of rodents to study NAFLD/NASH, careful analysis or reading highlights the fact that liver tissue evaluations reported in many of the popular animal models of NAFLD/NASH often do not imitate many of the significant aspects of the human disease, despite similar terminology applied by investigators. This review will focus on the findings in human disease.
Brunt
Elizabeth M
EM
Department of Pathology and Immunology, Washington University School of Medicine, 660 S. Euclid Ave, Box 8118, St. Louis, MO 63110, USA. ebrunt@wustl.edu
D000328:Adult; D002648:Child; D003937:Diagnosis, Differential; D005234:Fatty Liver / Q000150:complications / Q000473:pathology*; D006801:Humans; D008103:Liver Cirrhosis / Q000209:etiology / Q000473:pathology*