title: 1H and 13C NMR assignments of all three isomeric o-fluoronaphthaldehydes and three o-fluorophenanthrene aldehydes.
abstract: Three isomeric o-fluoronaphthaldehydes, 9-fluorophenanthrene, and three previously unreported o-fluorophenanthrene aldehydes were analyzed in detail by multiple NMR techniques to provide unambiguous assignment of structures and resonances. The six aldehydes serve as the key starting materials for novel chiral ligands used in highly enantioselective rhodium-catalyzed asymmetric hydrogenation reactions.
authors.affiliation: Department of Chemical Development, Boehringer-Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, Ridgefield, CT 06877, USA. carl.busacca@boehringer-ingelheim.com
authors.forename: Carl A
authors.initials: CA
authors.lastname: Busacca
authors.forename: Scot
authors.initials: S
authors.lastname: Campbell
authors.forename: Nina C
authors.initials: NC
authors.lastname: Gonnella
authors.forename: Chris H
authors.initials: CH
authors.lastname: Senanayake
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D002247:Carbon Isotopes; D005461:Fluorine / Q000737:chemistry*; D006859:Hydrogen; D007536:Isomerism; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009281:Naphthalenes / Q000737:chemistry*; D010616:Phenanthrenes / Q000737:chemistry*
chemical_list: C547444:1-fluoronaphthaldehyde; D000447:Aldehydes; D002247:Carbon Isotopes; D008024:Ligands; D009281:Naphthalenes; D010616:Phenanthrenes; D005461:Fluorine; C031181:phenanthrene; C009840:1-naphthaldehyde; D006859:Hydrogen