[The role of hepatic and erythrocyte aldehyde dehydrogenase in the development of burn toxemia in rats].
The study was designed to examine catalytic properties of non-specific aldehyde dehydrogenase from rat liver and erythrocyte as the main markers of endogenous intoxication after burn. Enzymatic activity was assayed from changes in the rate of NADH synthesis during acetaldehyde oxidation. Burn was shown to decrease it both in the liver and in erythrocytes which resulted in the accumulation of toxic aldehydes and the development of intoxication. Simultaneous fall in alcohol dehydrogenase and lactate dehydrogenase activities is supposed to contribute to the decrease of aldehyde dehydrogenase activity as a result of thermal injury.
Solov'eva
A G
AG
D000444:Aldehyde Dehydrogenase / Q000378:metabolism*; D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D002056:Burns / Q000150:complications* / Q000201:enzymology; D004195:Disease Models, Animal; D018450:Disease Progression; D019446:Endotoxemia / Q000201:enzymology* / Q000209:etiology; D004912:Erythrocytes / Q000201:enzymology*; D008099:Liver / Q000201:enzymology*; D008297:Male; D011379:Prognosis; D051381:Rats
D015415:Biomarkers; D000444:Aldehyde Dehydrogenase