Prebiotic foodstuffs and their health benefits in experiment.
OBJECTIVE
The aim of the present experimental study was to evaluate the effect of prebiotic on chemically induced carcinogenensis in rats fed with high fat diet (HF).


METHODS
Wistar albino rats were divided into control and experimental groups. In experimental group rats were treated with prebiotic at the dose of 2% of HF diet. N,N-dimethylhydrazine (DMH) injections were applicated in dose 20 mg/kg b.w., two times at week interval. In the end of eight weeks experimental period blood samples and feaces were taken from the rats and used for laboratory analysis.


RESULTS
Treatment with prebiotic inulin significantly (p < 0.001) decreased enzymatic activity of bacterial enzymes in feaces. Similar tendency was noticed in concentration of bile acids and lipid parameters. Prebiotic undergo fermentation in the colon and enhanced short chain fatty acid production.


CONCLUSIONS
Prebiotics may have potential health implications for protection against colon cancer (Tab. 2, Fig. 1, Ref. 14).
Hijova
E
E
Institute of Experimental Medicine, Faculty of Medicine, Safarikiensis University, Kosice, Research Institute for Animal Production, Nitra, Slovakia. hijova@pobox.sk
Chmelarova
A
A
Bomba
A
A
Zitnan
R
R
D000818:Animals; D001419:Bacteria / Q000201:enzymology; D003110:Colonic Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D005243:Feces / Q000382:microbiology; D007444:Inulin / Q000627:therapeutic use*; D019936:Probiotics / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
D007444:Inulin