Impact of CPAP treatment on cardiac biomarkers and pro-BNP in obstructive sleep apnea syndrome.
OBJECTIVE
To evaluate the effect of continuous positive airway pressure (CPAP) therapy on pro-brain natriuretic peptide (BNP) and cardiac markers in patients with obstructive sleep apnea syndrome and normal cardiac function.


METHODS
Thirty-three consecutive patients with sleep apnea syndrome were analysed for serum pro-BNP and cardiac markers prior to and after 6 months of CPAP therapy.


RESULTS
Twenty five patients had normal (83.3%) while remaining five (16.7%) revealed high pro-BNP values. We did not detect any significant difference between severity of obstructive sleep apnea syndrome and serum pro-BNP levels (p = 0.534). A statistically significant difference was not observed between basal and sixth-month creatine kinase (CK), creatine kinase-MB (CK-MB), troponin I, pro-BNP, aspartate transaminase (AST), and CK levels in patients with sleep apnea syndrome (p > 0.05).


CONCLUSIONS
Obstructive sleep apnea syndrome does not induce myocardial damage enough to increase serum pro-BNP, CK, CK-MB, troponin I, and AST levels. Markers sensitive to ischemia could be preferred to evaluate effect of obstructive sleep apnea syndrome.
Cifçi
Nilüfer
N
Department of Pulmonary Diseases, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey.
Uyar
Meral
M
Elbek
Osman
O
Süyür
Hüseyin
H
Ekinci
Erhan
E
D000328:Adult; D001219:Aspartate Aminotransferases / Q000097:blood; D045422:Continuous Positive Airway Pressure; D003402:Creatine Kinase / Q000097:blood*; D052279:Creatine Kinase, MB Form / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D017286:Polysomnography; D011446:Prospective Studies; D011498:Protein Precursors / Q000097:blood; D012016:Reference Values; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000175:diagnosis / Q000628:therapy*; D019210:Troponin I / Q000097:blood*
D011498:Protein Precursors; D019210:Troponin I; D020097:Natriuretic Peptide, Brain; D001219:Aspartate Aminotransferases; D003402:Creatine Kinase; D052279:Creatine Kinase, MB Form