Synthesis of tetraglucosyl- and tetrapolyamine-tetrabenzoporphyrin conjugates for an application in PDT.
This paper reports the synthesis and characterization of a new class of tetrabenzoporphyrins bearing glucosyl or polyamine units on meso positions to improve the targeting of cancer cells. Photocytotoxic activity of these photosensitizers was tested on cell lines HaCaT and MCF-7 and compared to Photofrin II.
Ménard
Florian
F
Université de Limoges, Laboratoire de Chimie des Substances Naturelles EA 1069, Faculté des Sciences et Techniques, 123 Av. Albert Thomas, 87060 Limoges, France.
Sol
Vincent
V
Ringot
Cyril
C
Granet
Robert
R
Alves
Sandra
S
Morvan
Caroline Le
CL
Queneau
Yves
Y
Ono
Noboru
N
Krausz
Pierre
P
D000818:Animals; D001555:Benzene Derivatives / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D001681:Biological Assay; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology; D045744:Cell Line, Tumor; D005260:Female; D005947:Glucose / Q000031:analogs & derivatives / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D008956:Models, Chemical; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use*; D011073:Polyamines / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D011166:Porphyrins / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use
D001555:Benzene Derivatives; D017319:Photosensitizing Agents; D011073:Polyamines; D011166:Porphyrins; D005947:Glucose