Cytogenetics and molecular genetics of acute lymphoblastic leukemia.
Acute lymphoblastic leukemia (ALL) is a malignant disease that often features nonrandom numerical or structural chromosome aberrations that can be detected microscopically. The application of contemporary genome-wide molecular analyses is revealing additional genetic alterations that are not detectable cytogenetically. This article describes the cytogenetic methodology and summarizes major cytogenetic findings and their clinical relevance in ALL. The article provides a review of modern molecular techniques and their application in the research on the genetics and epigenetics of ALL.
Mrózek
Krzysztof
K
Division of Hematology and Oncology, Department of Internal Medicine, Comprehensive Cancer Center, James Cancer Hospital, The Ohio State University, Room 1248B, 300 West Tenth Avenue, Columbus, OH 43210-1228, USA. krzysztof.mrozek@osumc.edu
Harper
David P
DP
Aplan
Peter D
PD
D002869:Chromosome Aberrations; D020732:Cytogenetic Analysis; D003582:Cytogenetics; D006801:Humans; D008967:Molecular Biology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000473:pathology