title: Very late-onset group B Streptococcus meningitis, sepsis, and systemic shigellosis due to interleukin-1 receptor-associated kinase-4 deficiency.
abstract: We describe a child with very late-onset group B Streptococcus sepsis and meningitis, systemic shigellosis, and chronic osteomyelitis. Peripheral blood cells obtained from the patient and her brother did not respond to stimulation with either interleukin-1beta or lipopolysaccharide. Sequencing of the interleukin-1 receptor-associated kinase-4 gene revealed 2 novel mutations.
authors.affiliation: Department of Pediatrics, Division of Pediatric Infectious Diseases, Vanderbilt University, Nashville, Tennessee, USA.
authors.forename: Jens C
authors.initials: JC
authors.lastname: Krause
authors.forename: Pegah
authors.initials: P
authors.lastname: Ghandil
authors.forename: Maya
authors.initials: M
authors.lastname: Chrabieh
authors.forename: Jean-Laurent
authors.initials: JL
authors.lastname: Casanova
authors.forename: Capucine
authors.initials: C
authors.lastname: Picard
authors.forename: Anne
authors.initials: A
authors.lastname: Puel
authors.forename: C Buddy
authors.initials: CB
authors.lastname: Creech
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D004405:Dysentery, Bacillary / Q000188:drug therapy / Q000235:genetics / Q000382:microbiology*; D005260:Female; D006801:Humans; D007223:Infant; D053592:Interleukin-1 Receptor-Associated Kinases / Q000172:deficiency* / Q000235:genetics; D008581:Meningitis / Q000188:drug therapy / Q000235:genetics / Q000382:microbiology*; D018805:Sepsis / Q000188:drug therapy / Q000235:genetics / Q000382:microbiology*; D013292:Streptococcus agalactiae / Q000472:pathogenicity*
chemical_list: D000900:Anti-Bacterial Agents; D053592:Interleukin-1 Receptor-Associated Kinases