title: Tinnitus intensity dependent gamma oscillations of the contralateral auditory cortex.
abstract: BACKGROUND
  Non-pulsatile tinnitus is considered a subjective auditory phantom phenomenon present in 10 to 15% of the population. Tinnitus as a phantom phenomenon is related to hyperactivity and reorganization of the auditory cortex. Magnetoencephalography studies demonstrate a correlation between gamma band activity in the contralateral auditory cortex and the presence of tinnitus. The present study aims to investigate the relation between objective gamma-band activity in the contralateral auditory cortex and subjective tinnitus loudness scores.
  
  
  RESULTS
  In unilateral tinnitus patients (N = 15; 10 right, 5 left) source analysis of resting state electroencephalographic gamma band oscillations shows a strong positive correlation with Visual Analogue Scale loudness scores in the contralateral auditory cortex (max r = 0.73, p<0.05).
  
  
  CONCLUSIONS
  Auditory phantom percepts thus show similar sound level dependent activation of the contralateral auditory cortex as observed in normal audition. In view of recent consciousness models and tinnitus network models these results suggest tinnitus loudness is coded by gamma band activity in the contralateral auditory cortex but might not, by itself, be responsible for tinnitus perception.
authors.affiliation: Brain Research centre Antwerp for Innovative and Interdisciplinary Neuromodulation (BRAI(2)N), University Hospital Antwerp, Antwerp, Belgium. elsa.vanderloo@ua.ac.be
authors.forename: Elsa
authors.initials: E
authors.lastname: van der Loo
authors.forename: Steffen
authors.initials: S
authors.lastname: Gais
authors.forename: Marco
authors.initials: M
authors.lastname: Congedo
authors.forename: Sven
authors.initials: S
authors.lastname: Vanneste
authors.forename: Mark
authors.initials: M
authors.lastname: Plazier
authors.forename: Tomas
authors.initials: T
authors.lastname: Menovsky
authors.forename: Paul
authors.initials: P
authors.lastname: Van de Heyning
authors.forename: Dirk
authors.initials: D
authors.lastname: De Ridder
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D000368:Aged; D001303:Auditory Cortex / Q000033:anatomy & histology* / Q000503:physiopathology*; D004569:Electroencephalography / Q000379:methods; D005260:Female; D006320:Hearing Tests / Q000379:methods; D006801:Humans; D015225:Magnetoencephalography / Q000379:methods; D008297:Male; D008875:Middle Aged; D009991:Oscillometry / Q000379:methods*; D014012:Tinnitus / Q000175:diagnosis* / Q000503:physiopathology*