title: Eosinophilia and thrombosis in parasitic diseases: an overview.
abstract: It is known that peripheral blood eosinophilia (PBE) is a normal hematopoietic response to several parasitic diseases, but it is less known that PBE promotes a hypercoagulable state that may favor thrombosis. Scope of this article is to explore which parasitic infestations are most likely to be complicated by thrombosis and to highlight the pathogenetic contribution of PBE to vascular occlusions in this setting. A review of the world literature revealed 18 cases in which PBE was associated with vascular occlusion though no specific surveys were dedicated to this topic. The eosinophil exerts its thrombogenic potential by inhibition of the natural anticoagulant pathways and release of tissue factor with enhanced coagulation activation leading to vascular occlusion. It is hoped that this review contributes to the awareness of the link between PBE and thrombosis in parasitic disorders to foster research in this area.
authors.affiliation: Haematology and Rheumatology Department, Airedale General Hospital, Sutton, United Kingdom. paxmes@aol.com
authors.forename: Paul R J
authors.initials: PR
authors.lastname: Ames
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Aloj
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Gentile
mesh_terms: D000328:Adult; D000368:Aged; D001777:Blood Coagulation; D004802:Eosinophilia / Q000097:blood / Q000209:etiology / Q000469:parasitology; D004804:Eosinophils / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010272:Parasitic Diseases / Q000097:blood / Q000150:complications; D019851:Thrombophilia / Q000097:blood / Q000209:etiology / Q000469:parasitology; D013925:Thromboplastin / Q000378:metabolism; D013927:Thrombosis / Q000097:blood / Q000209:etiology / Q000469:parasitology
chemical_list: D013925:Thromboplastin