title: PDC expressing CD36, CD61 and IL-10 may contribute to propagation of immune tolerance.
abstract: Human plasmacytoid dendritic cells (PDC) are blood dendritic cell antigen 2 (BDCA2) and blood dendritic cell antigen 4 (BDCA4) positive leukocytes that do not express common lineage markers. They have been described as proinflammatory innate immune cells and are the major source of alphaIFN in the human body. PDC-derived secretion of type I IFNs upon triggering of nucleic acid-sensing toll-like receptors (TLR) primes immune cells to rapidly respond to microbial stimuli and promotes a Th1 response. Here, we report that human PDC express CD36 and CD61 (beta3 integrin), both involved in uptake of apoptotic cells and in induction of tolerance. Freshly isolated PDC and PDC within human blood leukocytes constitutively express IL-10. Thus, PDC may possess a so far neglected role in propagation of immune tolerance.
authors.affiliation: Department of Medical Microbiology and Hygiene, Heidelberg University Hospital, Hygiene Institute, Heidelberg, Germany.
authors.forename: Marijo
authors.initials: M
authors.lastname: Parcina
authors.forename: Martin
authors.initials: M
authors.lastname: Schiller
authors.forename: Aline
authors.initials: A
authors.lastname: Gierschke
authors.forename: Klaus
authors.initials: K
authors.lastname: Heeg
authors.forename: Isabelle
authors.initials: I
authors.lastname: Bekeredjian-Ding
mesh_terms: D018955:CD36 Antigens / Q000096:biosynthesis / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology* / Q000378:metabolism; D005434:Flow Cytometry; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology*; D039661:Integrin beta3 / Q000096:biosynthesis / Q000276:immunology*; D016753:Interleukin-10 / Q000096:biosynthesis / Q000276:immunology*
chemical_list: D018955:CD36 Antigens; D039661:Integrin beta3; D016753:Interleukin-10