title: Warm, beating heart aortic valve replacement in a sickle cell patient.
abstract: Patients with sickle cell abnormalities undergoing surgery are generally considered to be at greater risk for perioperative complications. We present a 25-year-old woman with sickle cell disease (SCD) and severe aortic insufficiency. A minimally invasive, warm, beating heart approach was adopted to try and minimize the risk of sickling due to cardiopulmonary bypass (CPB), low-flow states, cold cardioplegia and aortic cross-clamping. Compared to classical methods, we believe our technique further reduces the risk of systemic and organ hypothermia and thus, sickling.
authors.affiliation: Department of Cardiothoracic Surgery, Staten Island University Hospital, 475 Seaview Avenue, Staten Island, NY 10305, USA. saif.usman@gmail.com
authors.forename: Saif
authors.initials: S
authors.lastname: Usman
authors.forename: Faisal B
authors.initials: FB
authors.lastname: Saiful
authors.forename: Joseph
authors.initials: J
authors.lastname: DiNatale
authors.forename: Joseph T
authors.initials: JT
authors.lastname: McGinn
mesh_terms: D000328:Adult; D000755:Anemia, Sickle Cell / Q000097:blood / Q000150:complications*; D001021:Aortic Valve / Q000601:surgery*; D001022:Aortic Valve Insufficiency / Q000150:complications / Q000000981:diagnostic imaging / Q000601:surgery*; D002315:Cardiopulmonary Bypass / Q000009:adverse effects; D005260:Female; D019918:Heart Valve Prosthesis Implantation / Q000009:adverse effects / Q000379:methods*; D006801:Humans; D008944:Mitral Valve Insufficiency / Q000150:complications; D056346:Sternotomy; D016896:Treatment Outcome; D014262:Tricuspid Valve Insufficiency / Q000150:complications; D014463:Ultrasonography