title: Impact of mild hypertension on left atrial size and function.
abstract: BACKGROUND
  Left atrial (LA) enlargement has been documented to occur in moderate and severe hypertension.
  
  
  RESULTS
  One hundred twelve mild hypertension patients were prospectively recruited and compared with 198 healthy volunteers. All recruits had a transthoracic echocardiogram. Maximum LA biplane volume, minimum LA biplane volume, and pre 'p'-LA biplane volume were measured, and left atrial passive, active emptying, and conduit volumes were calculated at baseline and in a subgroup of patients after 12 months. After adjusting for age, gender, and body mass index, maximum LA biplane volume, pre 'p'-LA biplane volume, and their indexed volumes were increased in the hypertension group. Active emptying volume and fraction were significantly increased in the hypertension group, with no change in conduit and passive volumes. Subgroup analysis comparing hypertensives with normal/mildly increased left ventricular mass (group 1) with those with moderate/severely increased left ventricular mass (group 2) at baseline demonstrated that maximum LA biplane volume (62.8+/-17.9 mL versus 45.4+/-13.7 mL; P<0.001) was significantly increased in group 2. Active emptying volume was also increased.
  
  
  CONCLUSIONS
  Even mild hypertension seems to be associated with a reduction in early diastolic filling. This results in augmented late left ventricular diastolic filling due to active atrial contraction and may be the mechanism for the increase in left atrial size.
authors.affiliation: Westmead Hospital, University of Sydney, Sydney, Australia. suzannee@westgate.wh.usyd.edu.au
authors.forename: Suzanne
authors.initials: S
authors.lastname: Eshoo
authors.forename: David L
authors.initials: DL
authors.lastname: Ross
authors.forename: Liza
authors.initials: L
authors.lastname: Thomas
mesh_terms: D016279:Atrial Function, Left; D003971:Diastole; D004452:Echocardiography; D015150:Echocardiography, Doppler; D005260:Female; D006325:Heart Atria / Q000000981:diagnostic imaging; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000503:physiopathology*; D017379:Hypertrophy, Left Ventricular / Q000000981:diagnostic imaging / Q000209:etiology; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000000981:diagnostic imaging / Q000503:physiopathology; D016277:Ventricular Function, Left