Working memory and long-term memory deficits in schizophrenia: is there a common substrate?
Patients with schizophrenia exhibit substantial deficits in both working memory (WM) and long-term memory (LTM) tasks. While these two forms of memory are generally viewed as distinct, recent evidence from healthy subjects has challenged the robustness of the double-dissociation between these two types of memory. In light of an emerging view of WM and LTM as being subserved by a largely overlapping network of brain regions, it is possible that WM and LTM deficits in patients with schizophrenia share a common neurobiological substrate. This review revisits the functional neuroimaging literature on both WM and LTM in patients with schizophrenia with these considerations in mind, and reveals a number of commonalities in research findings in both literatures. While there is a paucity of direct evidence bearing on whether patient deficits in these tasks arise from a common functional abnormality, the available literature is consistent with the hypothesis that these deficits have the same origin.
Van Snellenberg
Jared Xavier
JX
Department of Psychology, Columbia University, New York, NY 10027, United States. jared@psych.columbia.edu
D001931:Brain Mapping; D003072:Cognition Disorders / Q000209:etiology; D003952:Diagnostic Imaging / Q000379:methods; D006801:Humans; D008568:Memory / Q000145:classification*; D008569:Memory Disorders / Q000209:etiology* / Q000473:pathology*; D012559:Schizophrenia / Q000150:complications*; D012565:Schizophrenic Psychology