title: Novel therapeutics approaches to chronic lymphocytic leukemia based on recent biological insights.
abstract: Chronic lymphocytic leukemia (CLL) is a malignancy mainly affecting elderly people and is still considered an incurable disease. Despite recent advances in CLL treatment, relapse rates are high and often accompanied by the development of resistance towards conventional chemotherapy. Thus, new agents are needed for the treatment of these patients. In recent years, our understanding of the biological mechanisms driving CLL pathogenesis has considerably improved, and novel treatment strategies are arising. This review summarizes recent insights in CLL biology and describes several new agents and treatment strategies that are currently explored in pre-clinical studies and early-phase clinical trials.
authors.affiliation: Laboratory for Immunological and Molecular Cancer Research, IIIrd Medical Department with Hematology, Medical Oncology, Hemostaseology, Rheumatology and Infectiology, Paracelsus Medical University, Salzburg 5020, Austria.
authors.forename: Tanja N
authors.initials: TN
authors.lastname: Hartmann
authors.forename: Lisa
authors.initials: L
authors.lastname: Pleyer
authors.forename: Petra
authors.initials: P
authors.lastname: Desch
authors.forename: Alexander
authors.initials: A
authors.lastname: Egle
authors.forename: Richard
authors.initials: R
authors.lastname: Greil
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D017209:Apoptosis / Q000235:genetics / Q000502:physiology; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000188:drug therapy* / Q000378:metabolism*; D011947:Receptors, Antigen, B-Cell / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects / Q000235:genetics / Q000502:physiology
chemical_list: D000970:Antineoplastic Agents; D011947:Receptors, Antigen, B-Cell