title: Benzothiazoles as Rho-associated kinase (ROCK-II) inhibitors.
abstract: A series of benzothiazole derivatives as ROCK inhibitors have been discovered. Compounds with good biochemical and cellular potency, and sufficient kinase selectivity have been identified.
authors.affiliation: Translational Research Institute and Department of Molecular Therapeutics, The Scripps Research Institute, Florida, 130 Scripps Way #2A1, Jupiter, FL 33458, United States.
authors.forename: Yan
authors.initials: Y
authors.lastname: Yin
authors.forename: Li
authors.initials: L
authors.lastname: Lin
authors.forename: Claudia
authors.initials: C
authors.lastname: Ruiz
authors.forename: Michael D
authors.initials: MD
authors.lastname: Cameron
authors.forename: Jennifer
authors.initials: J
authors.lastname: Pocas
authors.forename: Wayne
authors.initials: W
authors.lastname: Grant
authors.forename: Thomas
authors.initials: T
authors.lastname: Schröter
authors.forename: Weimin
authors.initials: W
authors.lastname: Chen
authors.forename: Derek
authors.initials: D
authors.lastname: Duckett
authors.forename: Stephan
authors.initials: S
authors.lastname: Schürer
authors.forename: Philip
authors.initials: P
authors.lastname: Lograsso
authors.forename: Yangbo
authors.initials: Y
authors.lastname: Feng
mesh_terms: D052160:Benzothiazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D015195:Drug Design; D015394:Molecular Structure; D047428:Protein Kinase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D054460:rho-Associated Kinases / Q000037:antagonists & inhibitors*
chemical_list: D052160:Benzothiazoles; D047428:Protein Kinase Inhibitors; D054460:rho-Associated Kinases