Role of subcutaneous abdominal fat on cardiac function and proinflammatory cytokines in premenopausal obese women.
The role of surgically removing subcutaneous fat by abdominoplasty on circulating inflammatory markers and myocardial dysfunction, evaluated by myocardial performance index (MPI), were investigated. Twenty volunteers submitted to the abdominoplasty (abdominoplasty group), and other 28 women treated by hypocaloric diet (diet group) were evaluated. Echocardiographic parameters of MPI, circulating levels of tumor necrosis factor (TNF)-alpha and interleukin (IL)-6, were performed at baseline and 2 months later. Compared with nonobese women, obese women had increased concentrations of TNF-alpha (P < 0.01), IL-6 (P < 0.01), and higher MPI (P < 0.02), indicating ventricular dysfunction. Subcutaneous fat concentrations of TNF-alpha and IL-6 were related to MPI impairment. After 60 days, waist-to hip ratio was significantly reduced in the abdominoplasty group. Anthropometric changes were accompanied by a significant decline in plasma concentrations of TNF-alpha and IL-6 levels as well as by significant improvements of MPI in abdominoplasty group compared with diet group. Abdominoplasty may represent a safe method for ameliorating cardiac function in obese women.
Marfella
Raffaele
R
Department of Geriatrics and Metabolic Diseases, Second University of Naples, Italy. raffaele.marfella@unina2.it
Grella
Roberto
R
Rizzo
Maria Rosaria
MR
Barbieri
Michelangela
M
Grella
Rodolfo
R
Ferraraccio
Franca
F
Cacciapuoti
Federico
F
Mazzarella
Gennaro
G
Ferraro
Nicola
N
D'Andrea
Francesco
F
Paolisso
Giuseppe
G
Nicoletti
Gianfranco
G
D000328:Adult; D016207:Cytokines / Q000032:analysis / Q000502:physiology*; D015150:Echocardiography, Doppler; D002149:Energy Intake; D005260:Female; D006321:Heart / Q000502:physiology*; D006801:Humans; D007150:Immunohistochemistry; D015850:Interleukin-6 / Q000502:physiology; D015187:Lipectomy; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000503:physiopathology*; D011184:Postoperative Period; D050507:Subcutaneous Fat, Abdominal / Q000737:chemistry / Q000502:physiology* / Q000601:surgery*; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology; D049629:Waist-Hip Ratio
D016207:Cytokines; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha