title: Neuroblastoma involvement of the falx cerebri.
abstract: Involvement of the falx cerebri in infants with stage 4 neuroblastoma is thought to be rare. The falx is derived from the neural crest and thus may be a location for primary neuroblastoma. Its propensity for metastasis is unknown. Management of neuroblastoma in this location is potentially challenging. We describe two children less than 18 months of age who were successfully managed with chemotherapy alone (without radiation or surgery) for falx involvement with neuroblastoma.
authors.affiliation: Dalhousie University, Halifax, Nova Scotia, Canada.
authors.forename: Katherine Elizabeth
authors.initials: KE
authors.lastname: Quackenbush
authors.forename: Sandra
authors.initials: S
authors.lastname: Luna-Fineman
authors.forename: James Fergall
authors.initials: JF
authors.lastname: Magee
authors.forename: Munire
authors.initials: M
authors.lastname: Gundogan
authors.forename: Mahin
authors.initials: M
authors.lastname: Golobi
authors.forename: Takeshi
authors.initials: T
authors.lastname: Irie
authors.forename: Conrad Vincent
authors.initials: CV
authors.lastname: Fernandez
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D000315:Adrenalectomy; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage; D019070:Cell Lineage; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D004388:Dura Mater / Q000473:pathology*; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008577:Meningeal Neoplasms / Q000188:drug therapy / Q000556:secondary*; D051739:Microphthalmia-Associated Transcription Factor / Q000235:genetics; D009367:Neoplasm Staging; D009432:Neural Crest; D009447:Neuroblastoma / Q000188:drug therapy / Q000235:genetics / Q000473:pathology / Q000556:secondary* / Q000601:surgery; D011667:Pulmonary Veins / Q000002:abnormalities; D012074:Remission Induction; D012878:Skin Neoplasms / Q000188:drug therapy / Q000556:secondary; D014849:Waardenburg Syndrome / Q000150:complications / Q000235:genetics
chemical_list: C497234:MITF protein, human; D051739:Microphthalmia-Associated Transcription Factor; D005047:Etoposide; D004317:Doxorubicin; D003520:Cyclophosphamide; D016190:Carboplatin