title: Preparation and antitubercular activity of lipophilic diamines and amino alcohols.
abstract: A series of diamines and amino alcohols derived from 1-dodecanol, 1-tetradecanol, 1,2-dodecanediol and 1,2-tetradecanediol were synthesized and tested for their antitubercular activity. Compounds 3, 8 and 9 were found to be the most active (MIC of 6.25 microg/mL). Nine other compounds displayed activity against Mycobacterium tuberculosis, with a MIC of 12.5 microg/mL.
authors.affiliation: Departamento de Química, Universidade Federal de Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil.
authors.forename: Celso O R
authors.initials: CO
authors.lastname: Júnior
authors.forename: Mireille
authors.initials: M
authors.lastname: le Hyaric
authors.forename: Cristiane F da
authors.initials: CF
authors.lastname: Costa
authors.forename: Taís A
authors.initials: TA
authors.lastname: Corrêa
authors.forename: Aline F
authors.initials: AF
authors.lastname: Taveira
authors.forename: Débora P
authors.initials: DP
authors.lastname: Araújo
authors.forename: Elaine F C
authors.initials: EF
authors.lastname: Reis
authors.forename: Maria Cristina S
authors.initials: MC
authors.lastname: Lourenço
authors.forename: Felipe R C
authors.initials: FR
authors.lastname: Vicente
authors.forename: Mauro V de
authors.initials: MV
authors.lastname: Almeida
mesh_terms: D000605:Amino Alcohols / Q000138:chemical synthesis / Q000494:pharmacology*; D000995:Antitubercular Agents / Q000737:chemistry / Q000494:pharmacology*; D003959:Diamines / Q000138:chemical synthesis / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects*
chemical_list: D000605:Amino Alcohols; D000995:Antitubercular Agents; D003959:Diamines