Sonodynamic and photodynamic therapy in advanced breast carcinoma: a report of 3 cases.
Photodynamic therapy (PDT) is an established therapeutic method, first approved by the FDA for certain kinds of cancer in 1998. There are also increasing data to show that a related procedure, sonodynamic therapy (SDT), is a promising new modality for cancer treatment. Here, the authors report clinical results in 3 advanced refractory breast cancer patients who were treated using a combination of sonodynamic and photodynamic therapy (SPDT), along with conventional therapies. All 3 patients had pathologically proven metastatic breast carcinoma. These widely disseminated carcinomas had ultimately failed to respond to conventional therapy. A new sensitizing agent, Sonoflora 1 (SF1) was administered sublingually; then, after a 24-hour delay, patients were treated with a combination of light and ultrasound. All patients had significant partial or complete responses. SPDT is a promising new therapeutic combination for the treatment of breast cancer.
Wang
Xiaohuai
X
Chemistry and Environment College, Southern China Normal University, Guangzhou, People's Republic of China. wangxhgz@163.com
Zhang
Weimin
W
Xu
Zhiyong
Z
Luo
Yifan
Y
Mitchell
Doug
D
Moss
Ralph W
RW
D000286:Administration, Sublingual; D000328:Adult; D001943:Breast Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000628:therapy*; D002277:Carcinoma / Q000175:diagnosis / Q000473:pathology / Q000628:therapy*; D002734:Chlorophyll / Q000031:analogs & derivatives / Q000627:therapeutic use; D003131:Combined Modality Therapy / Q000379:methods; D000529:Complementary Therapies / Q000295:instrumentation / Q000379:methods*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008875:Middle Aged; D009362:Neoplasm Metastasis / Q000175:diagnosis / Q000473:pathology / Q000628:therapy; D010778:Photochemotherapy / Q000295:instrumentation / Q000379:methods*; D017319:Photosensitizing Agents / Q000008:administration & dosage / Q000627:therapeutic use; D049268:Positron-Emission Tomography; D016896:Treatment Outcome; D014464:Ultrasonic Therapy / Q000295:instrumentation / Q000379:methods*
D017319:Photosensitizing Agents; D002734:Chlorophyll