title: 'Orphan drugs' in cardiology: nadolol and quinidine.
abstract: The recent withdrawal from the market of nadolol (Corgard; Bristol-Myers Squibb, Sermoneta, Italy) and quinidine polygalacturonate (Ritmocor; Malesci, Bagno A Ripoli, Italy) has been causing clinical problems to many cardiologists and patients, frequently leading to discontinuance of an effective and well-tolerated pharmacological treatment. Nadolol is useful in the treatment of severe and refractory arrhythmias, particularly in some genetically determined ion-channel diseases, such as long-QT syndrome and catecholaminergic polymorphic ventricular tachycardia.Quinidine is still used in refractory atrial fibrillation recurrences. Recent studies have demonstrated the clinical efficacy of quinidine in the treatment of rare genetically determined ion-channel diseases at high risk of sudden death, such as Brugada syndrome and short-QT syndrome.We hope that scientific societies can influence healthcare and pharmaceutical institutions, in order to restore the availability of two cardiovascular drugs that are extremely important in the care of arrhythmic patients.
authors.affiliation: Division of Cardiology, Cardiocerebrovascular Department, Ospedale Maggiore, Crema, Italy. g.inama@hcrema.it
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Inama
authors.forename: Ornella
authors.initials: O
authors.lastname: Durin
authors.forename: Claudio
authors.initials: C
authors.lastname: Pedrinazzi
authors.forename: Massimo Zoni
authors.initials: MZ
authors.lastname: Berisso
authors.forename: Francesco
authors.initials: F
authors.lastname: Furlanello
mesh_terms: D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000188:drug therapy*; D002309:Cardiology; D004338:Drug Combinations; D056736:Drug Recalls; D006801:Humans; D009248:Nadolol / Q000627:therapeutic use*; D010368:Pectins / Q000627:therapeutic use*; D011802:Quinidine / Q000627:therapeutic use*
chemical_list: D000889:Anti-Arrhythmia Agents; D004338:Drug Combinations; D009248:Nadolol; D010368:Pectins; C047144:quinidine polygalacturonate; D011802:Quinidine