Id2-, RORgammat-, and LTbetaR-independent initiation of lymphoid organogenesis in ocular immunity.
The eye is protected by the ocular immunosurveillance system. We show that tear duct-associated lymphoid tissue (TALT) is located in the mouse lacrimal sac and shares immunological characteristics with mucosa-associated lymphoid tissues (MALTs), including the presence of M cells and immunocompetent cells for antigen uptake and subsequent generation of mucosal immune responses against ocularly encountered antigens and bacteria such as Pseudomonas aeruginosa. Initiation of TALT genesis began postnatally; it occurred even in germ-free conditions and was independent of signaling through organogenesis regulators, including inhibitor of DNA binding/differentiation 2, retinoic acid-related orphan receptor gammat, lymphotoxin (LT) alpha1beta2-LTbetaR, and lymphoid chemokines (CCL19, CCL21, and CXCL13). Thus, TALT shares immunological features with MALT but has a distinct tissue genesis mechanism and plays a key role in ocular immunity.
Nagatake
Takahiro
T
Division of Mucosal Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan.
Fukuyama
Satoshi
S
Kim
Dong-Young
DY
Goda
Kaoru
K
Igarashi
Osamu
O
Sato
Shintaro
S
Nochi
Tomonori
T
Sagara
Hiroshi
H
Yokota
Yoshifumi
Y
Jetten
Anton M
AM
Kaisho
Tsuneyasu
T
Akira
Shizuo
S
Mimuro
Hitomi
H
Sasakawa
Chihiro
C
Fukui
Yoshinori
Y
Fujihashi
Kohtaro
K
Akiyama
Taishin
T
Inoue
Jun-ichiro
J
Penninger
Josef M
JM
Kunisawa
Jun
J
Kiyono
Hiroshi
H
D000818:Animals; D000831:Animals, Newborn; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D004848:Epithelium / Q000276:immunology / Q000648:ultrastructure; D000939:Epitopes / Q000276:immunology; D007109:Immunity / Q000276:immunology*; D007114:Immunization; D007070:Immunoglobulin A / Q000276:immunology; D051797:Inhibitor of Differentiation Protein 2 / Q000378:metabolism; D007765:Lacrimal Apparatus / Q000196:embryology* / Q000276:immunology* / Q000382:microbiology / Q000648:ultrastructure; D008221:Lymphoid Tissue / Q000196:embryology* / Q000276:immunology* / Q000382:microbiology / Q000648:ultrastructure; D053361:Lymphotoxin alpha1, beta2 Heterotrimer / Q000378:metabolism; D051379:Mice; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3; D038081:Organogenesis / Q000276:immunology*; D018168:Receptors, Retinoic Acid / Q000378:metabolism; D011988:Receptors, Thyroid Hormone / Q000378:metabolism
D000939:Epitopes; C497452:Idb2 protein, mouse; D007070:Immunoglobulin A; D051797:Inhibitor of Differentiation Protein 2; D053361:Lymphotoxin alpha1, beta2 Heterotrimer; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3; D018168:Receptors, Retinoic Acid; D011988:Receptors, Thyroid Hormone; C539901:Rorc protein, mouse