title: Concomitant progressive supranuclear palsy and multiple system atrophy: more than a simple twist of fate?
abstract: Progressive supranuclear palsy (PSP) and multiple system atrophy (MSA) are both rare neurodegenerative diseases. In the Queen Square Brain Bank, from 2001 to 2008, we received 120 cases of pathologically confirmed PSP and 36 of MSA, and one had concomitant PSP and MSA pathology. The clinical symptoms in this case were compatible with PSP and did not predict the dual pathology. The growing number of collective case reports, including the one reported here, might suggest an increased prevalence of concomitant PSP and MSA than what would be expected by chance.
authors.affiliation: Reta Lila Weston Institute for Neurological Studies, UCL Institute of Neurology, London, UK.
authors.forename: Laura
authors.initials: L
authors.lastname: Silveira-Moriyama
authors.forename: Ana Marcos
authors.initials: AM
authors.lastname: González
authors.forename: Sean S
authors.initials: SS
authors.lastname: O'Sullivan
authors.forename: David R
authors.initials: DR
authors.lastname: Williams
authors.forename: Luke
authors.initials: L
authors.lastname: Massey
authors.forename: Laura
authors.initials: L
authors.lastname: Parkkinen
authors.forename: Zeshan
authors.initials: Z
authors.lastname: Ahmed
authors.forename: Rohan
authors.initials: R
authors.lastname: de Silva
authors.forename: Jose R
authors.initials: JR
authors.lastname: Chacón
authors.forename: Tamas
authors.initials: T
authors.lastname: Revesz
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Lees
authors.forename: Janice L
authors.initials: JL
authors.lastname: Holton
mesh_terms: D000368:Aged; D001253:Astrocytes / Q000378:metabolism / Q000473:pathology; D015415:Biomarkers / Q000378:metabolism; D001921:Brain / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D015897:Comorbidity; D018450:Disease Progression; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D002479:Inclusion Bodies / Q000378:metabolism / Q000473:pathology; D008403:Mass Screening; D019578:Multiple System Atrophy / Q000453:epidemiology* / Q000473:pathology* / Q000503:physiopathology; D009434:Neural Pathways / Q000378:metabolism / Q000473:pathology; D009474:Neurons / Q000378:metabolism / Q000473:pathology*; D009836:Oligodendroglia / Q000378:metabolism / Q000473:pathology; D010300:Parkinson Disease / Q000453:epidemiology / Q000473:pathology / Q000503:physiopathology; D015995:Prevalence; D012720:Severity of Illness Index; D013494:Supranuclear Palsy, Progressive / Q000453:epidemiology* / Q000473:pathology* / Q000503:physiopathology; D051844:alpha-Synuclein / Q000378:metabolism; D016875:tau Proteins / Q000378:metabolism
chemical_list: D015415:Biomarkers; D051844:alpha-Synuclein; D016875:tau Proteins