title: [Clinical features of cytomegalovirus pneumonia after allogeneic hematopoietic stem cell transplantation].
abstract: OBJECTIVE
  To analyze the clinical features and prognosis of cytomegalovirus (CMV) pneumonia after allogeneic hematopoietic stem-cell transplantation (allo-HSCT) under the preemptive therapy based on monitoring CMV-DNA level quantificationally.
  
  
  METHODS
  We studied 750 patients underwent allo-HSCT from Jan, 2005 to Aug, 2008. A total of 22 patients who developed into CMV pneumonia were analyzed retrospectively.
  
  
  RESULTS
  Twenty-four episodes of CMV pneumonia occurred in the 22 patients (2.9%) and the majority of them developed into CMV pneumonia average 51 days ( 30 to 180 days) after allo-HSCT. Of the 22 patients 16 (72.7%) underwent CMV-DNA emia and 6 remained CMV-PCR negative throughout the course of the disease. The pulmonary CT manifestation of 23 episodes showed specific features of interstitial changes, including diffused or patchy ground-glass opacities. Better curative effects were obtained using antivirus drugs combined with glucocorticoid and the total curative ratio of CMV pneumonia was 83.3%. Male and the occurrence of severe acute graft-versus-host disease seemed to be correlated with an unfavorable outcome through univariate analysis(P=0.034, P=0.023).
  
  
  CONCLUSIONS
  Making a diagnosis as soon as possible and appropriate therapy will improve the outcome of patients with CMV pneumonia markedly.
authors.affiliation: Institute of Hematology, Peking University People's Hospital, Beijing 100044, China.
authors.forename: Xiao Su
authors.initials: XS
authors.lastname: Zhao
authors.forename: Dai Hong
authors.initials: DH
authors.lastname: Liu
authors.forename: Lan Ping
authors.initials: LP
authors.lastname: Xu
authors.forename: Huan
authors.initials: H
authors.lastname: Chen
authors.forename: Yu Hong
authors.initials: YH
authors.lastname: Chen
authors.forename: Xiao Hui
authors.initials: XH
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Han
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
authors.forename: Kai Yan
authors.initials: KY
authors.lastname: Liu
authors.forename: Xiao Jun
authors.initials: XJ
authors.lastname: Huang
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003587:Cytomegalovirus / Q000302:isolation & purification; D003586:Cytomegalovirus Infections / Q000175:diagnosis* / Q000209:etiology*; D004279:DNA, Viral / Q000097:blood; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D007938:Leukemia / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011024:Pneumonia, Viral / Q000175:diagnosis / Q000209:etiology*; D016133:Polymerase Chain Reaction; D011379:Prognosis; D012189:Retrospective Studies; D014184:Transplantation, Homologous; D055815:Young Adult
chemical_list: D004279:DNA, Viral