title: [Three cases of isocyanate-induced hypersensitivity pneumonitis with different HRCT findings].
abstract: We reported 3 cases of hypersensitivity pneumonitis who had been exposed to polyurethane material containing diphenylmethane diisocyanate (MDI) for 1-12 weeks. They had cough, fever and dyspnea before admission. All 3 cases were diagnosed immunologically using anti-MDI antibodies. Chest HRCT findings of the 3 cases were different. Case 1 showed an organizing pneumonia (OP) pattern : patchy peripheral consolidation with air bronchogram and ground-glass opacities (GGO), and case 2 showed a nonspecific interstitial pneumonia (NSIP) pattern : consolidation and reticular shadows in both lower lobes. In addition, case 3 showed a hypersensitivity pneumonitis (HP) pattern : centrilobular GGO and diffuse granular shadows. All cases were successfully treated by corticosteroids alone. This suggests that different amounts of inhaled antigen can cause different HRCT findings.
authors.affiliation: Second Department of Internal Medicine, Nagasaki University School of Medicine.
authors.forename: Shintaro
authors.initials: S
authors.lastname: Hara
authors.forename: Kazuko
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Aya
authors.initials: A
authors.lastname: Yoda
authors.forename: Seiko
authors.initials: S
authors.lastname: Nakayama
authors.forename: Noriho
authors.initials: N
authors.lastname: Sakamoto
authors.forename: Yuji
authors.initials: Y
authors.lastname: Ishimatsu
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Mukae
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kohno
mesh_terms: D000542:Alveolitis, Extrinsic Allergic / Q000139:chemically induced* / Q000000981:diagnostic imaging* / Q000188:drug therapy; D006801:Humans; D017953:Isocyanates / Q000009:adverse effects* / Q000276:immunology; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage; D008875:Middle Aged; D009784:Occupational Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging*; D016273:Occupational Exposure / Q000009:adverse effects*; D020551:Pulse Therapy, Drug; D011856:Radiographic Image Enhancement; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D001559:Benzhydryl Compounds
chemical_list: D017953:Isocyanates; D008775:Methylprednisolone; C005969:4,4'-diphenylmethane diisocyanate; D001559:Benzhydryl Compounds