[Drug resistance in Mycobacterium tuberculosis during chronic intoxication by tobacco: clinical and experimental studies].
Case histories were studied in 405 smoking patients (including 84 inveterate tobacco smokers) (a study group) and 193 nonsmoking patients (a control group) with new-onset pulmonary tuberculosis. Smoking was found to lead to a significant increase in the cases of drug resistance (including multidrug resistance (MDR)) in Mycobacterium tuberculosis (MBT): the resistant strains were 42.9% in the smokers and 54.4% in the inveterate tobacco smokers versus 31.9% in the control group (p < 0.01). The experiments showed that after two MBT strains (H37 Ra and 4688) had grown on the tobacco smoke condensate media, 57.1% of the experimental cultures were resistant to both one and several agents (including MDR), as shown by a study using the absolute concentration method.
Shprykov
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D000328:Adult; D002908:Chronic Disease; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D012189:Retrospective Studies; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects*; D014028:Tobacco Smoke Pollution / Q000009:adverse effects*; D018088:Tuberculosis, Multidrug-Resistant / Q000382:microbiology*; D055815:Young Adult
D014028:Tobacco Smoke Pollution