[Design and synthesis of 3'-methyl-furanonucleosides and their anti-tumor activities].
Taking 3'-Me-Ado (3'-methyladenosine) and Cladribine as the leading compounds, seventeen 3'-C-methyl-furanonucleosides were designed and synthesized. All the structures were confirmed by 1H NMR and MS. The target compounds were tested in vitro against human pulmonary carcinoma A549, human colon carcinoma LOVO and human leukemia CEM by MTT assay. The results showed that these compounds possessed moderate cytotoxicities.
Shi
Li-Hong
LH
State Key Laboratory of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, Shanghai 200437, China. shilihong6@hotmail.com
Jin
Dong-Zhe
DZ
Zhou
Wei-Cheng
WC
Wang
Juan
J
Chen
Xiu-Hua
XH
D000241:Adenosine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D017338:Cladribine / Q000138:chemical synthesis / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure
D000970:Antineoplastic Agents; D017338:Cladribine; C031080:3-methyladenosine; D000241:Adenosine