The role of antimicrobial peptides in cardiovascular physiology and disease.
Antimicrobial peptides are natural peptide antibiotics, existing ubiquitously in both plant and animal kingdoms. They exhibit broad-spectrum antimicrobial activity and play an important role in host defense against invading microbes. Recently, these peptides have been shown to possess activities unrelated to direct microbial killing and be involved in the complex network of immune responses and inflammation. Thus, their role has now broadened beyond that of endogenous antibiotics. Because of their wide involvement in inflammatory response and the emerging role of inflammation in atherosclerosis, antimicrobial peptides have been proposed to represent an important link between inflammation and the pathogenesis of atherosclerotic cardiovascular diseases. This review highlights recent findings that support a role of these peptides in cardiovascular physiology and disease.
Li
Yifeng
Y
Department of Anesthesiology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA. wu0915@ucla.edu
D000595:Amino Acid Sequence; D000818:Animals; D023181:Antimicrobial Cationic Peptides / Q000737:chemistry / Q000276:immunology / Q000378:metabolism*; D050197:Atherosclerosis / Q000276:immunology*; D002318:Cardiovascular Diseases / Q000276:immunology*; D002320:Cardiovascular Physiological Phenomena; D002319:Cardiovascular System / Q000276:immunology*; D002417:Cattle; D006801:Humans; D008969:Molecular Sequence Data; D017433:Protein Structure, Secondary
D023181:Antimicrobial Cationic Peptides