A comparison of oestrogen receptor and progesterone receptor expression in endometrial polyps and endometrium of premenopausal women.
Polyps from the endometrium is a common cause of abnormal uterine bleeding and sometimes cause infertility and pelvic pain. The objective of this study was to measure the expression of hormone receptors (oestrogen receptor and progesterone receptor) in endometrial polyps and compare the results to surrounding endometrial tissue. This prospective study recruited 53 women prior to menopause. The study showed that the expression of oestrogen receptor was higher whereas the expression of progesterone receptor was lower than that of adjacent endometrial tissue. The results suggest that abnormal expression of hormone receptor contribute to endometrial polyps formation.
Peng
X
X
Hysteroscopic Centre, Fuxing Hospital, Capital Medical University, Beijing, People's Republic of China. peng_xue_bing@hotmail.com
Li
T
T
Xia
E
E
Xia
C
C
Liu
Y
Y
Yu
D
D
D000328:Adult; D004717:Endometrium / Q000378:metabolism* / Q000473:pathology; D047628:Estrogen Receptor alpha / Q000378:metabolism*; D005260:Female; D005498:Follicular Phase / Q000378:metabolism; D006728:Hormones / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D011127:Polyps / Q000378:metabolism* / Q000473:pathology; D017697:Premenopause / Q000378:metabolism*; D011446:Prospective Studies; D011980:Receptors, Progesterone / Q000378:metabolism*
D047628:Estrogen Receptor alpha; D006728:Hormones; D011980:Receptors, Progesterone; C101118:progesterone receptor A; C097314:progesterone receptor B