[Oxidative stress in the cardiovascular system of rats with chronic deficiency of cerebral dopamine].
The physiological significance of cardiac mitochondrial reactive oxygen species (ROS) regulation is unknown. In the current study, mitochondrial ROS (O2- and OH) generation, stable H2O2 and lipids peroxidation marker (malonic dialdehyde, MDA) pools, as well as pools of potent antioxidants--urea and uric acid--were determined in rat heart, miocardial mitochondria and in blood plasma and erytrocytes at low (44%) and high (96%) levels of cerebral dopamine-synthesis neurons destruction (by 6-hydroxidopamine treatment). In the untreated rats, ROS generation, H2O2 and MDA levels were low but in rats with chronic (3-4 month) deficiency of cerebral dopamine synthesis by nigro-striatal dopaminergic system, ROS generation and lipids peroxidation were progressively increased. Dopamine deficiency can improve mitochondrial efficiency of oxidative phosphorylation due to oxidative stress.
Talanov
S A
SA
Kotsiuruba
A V
AV
Korkach
Iu P
IuP
Sahach
V F
VF
D000818:Animals; D002319:Cardiovascular System / Q000378:metabolism*; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism*; D003342:Corpus Striatum / Q000378:metabolism; D004298:Dopamine / Q000172:deficiency*; D004912:Erythrocytes / Q000378:metabolism; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000097:blood / Q000378:metabolism; D008929:Mitochondria, Heart / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D018384:Oxidative Stress; D016627:Oxidopamine / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species / Q000097:blood / Q000378:metabolism; D013378:Substantia Nigra / Q000378:metabolism; D014508:Urea / Q000097:blood; D014527:Uric Acid / Q000378:metabolism
D017382:Reactive Oxygen Species; D014527:Uric Acid; D008315:Malondialdehyde; D016627:Oxidopamine; D014508:Urea; D004298:Dopamine