Highly enantioselective catalytic 1,3-dipolar cycloaddition involving 2,3-allenoate dipolarophiles.
A bisphosphoric acid-catalyzed 1,3-dipolar cycloaddition of buta-2,3-dienoates with azomethine ylides yields 3-methylenepyrrolidine derivatives with excellent enantioselectivity (up to 97% ee).
Yu
Jie
J
Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, 230026, China.
He
Long
L
Chen
Xiao-Hua
XH
Song
Jin
J
Chen
Wei-Jie
WJ
Gong
Liu-Zhu
LZ
D001391:Azo Compounds / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D015394:Molecular Structure; D010756:Phosphoric Acids / Q000737:chemistry*; D011759:Pyrrolidines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D013882:Thiosemicarbazones / Q000737:chemistry*
D001391:Azo Compounds; D010756:Phosphoric Acids; D011759:Pyrrolidines; D013882:Thiosemicarbazones; C512188:azomethine