CYP2A13, ADH1B, and ADH1C gene polymorphisms and pancreatic cancer risk.
OBJECTIVE
Pancreatic carcinoma etiology and molecular pathogenesis are weakly understood. Based on the assumption that genetic variation in carcinogen metabolism further modifies the risk of exposure-related cancers, we studied the association of polymorphisms in the tobacco carcinogen-metabolizing gene CYP2A13 (Arg101Stop) and the alcohol-metabolizing genes ADH1B (Arg48His) and ADH1C (Ile350Val) with pancreatic cancer risk.


METHODS
Polymorphisms were studied by allelic discrimination.


RESULTS
In a hospital-based case-control study, CYP2A13 variant alleles coding an inactive enzyme were found in 7 of 265 cancer-free controls and in none of 235 pancreatic carcinoma patients. Neither ADH1B or ADH1C polymorphisms alone nor their combinations showed a significant effect on pancreatic cancer risk.


CONCLUSIONS
The first study of the roles of CYP2A13, ADH1B, and ADH1C in pancreatic cancer etiology suggested that the controls may have a lower ability to bioactivate tobacco-derived procarcinogens than the cases.
Mohelnikova-Duchonova
Beatrice
B
Toxicogenomics Unit, National Institute of Public Health, Prague, Czech Republic.
Vrana
David
D
Holcatova
Ivana
I
Ryska
Miroslav
M
Smerhovsky
Zdenek
Z
Soucek
Pavel
P
D000368:Aged; D000426:Alcohol Dehydrogenase / Q000235:genetics*; D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics*; D002277:Carcinoma / Q000201:enzymology / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D015971:Gene Expression Regulation, Enzymologic; D015972:Gene Expression Regulation, Neoplastic; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006761:Hospitals; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010190:Pancreatic Neoplasms / Q000201:enzymology / Q000235:genetics*; D011110:Polymorphism, Genetic; D018570:Risk Assessment; D012307:Risk Factors
C489332:ADH1B protein, human; C420272:ADH1C protein, human; D000426:Alcohol Dehydrogenase; D001189:Aryl Hydrocarbon Hydroxylases; C414206:CYP2A13 protein, human