Working memory plasticity modulated by dopamine transporter genotype.
Dopamine (DA) is implicated in working memory (WM) functioning. Variations in the DA transporter (DAT1) gene (SLC6A3) regulate DA availability in striatum. Compared to DAT1 9/10-repeat carriers, homozygosity of the DAT1 10-repeat allele has been related to less active dopaminergic pathways. A group of younger adults received 4 weeks of computerized adaptive training on several WM tasks. All participants improved their performance as a function of training. However, DAT1 9/10-repeat carriers showed larger training-related gains than DAT1 10-repeat carriers in visuospatial WM. By contrast, the two groups were indistinguishable in baseline WM performance as well as in a variety of tasks assessing different cognitive abilities. This pattern of results provides novel evidence that WM plasticity is a more sensitive indicator of DAT1 gene-related cognitive differences than single-assessment performance scores.
Brehmer
Yvonne
Y
Aging Research Center, Karolinska Institute, Stockholm, Sweden. Yvonne.Brehmer@ki.se
Westerberg
Helena
H
Bellander
Martin
M
Fürth
Daniel
D
Karlsson
Sari
S
Bäckman
Lars
L
D000328:Adult; D050483:Dopamine Plasma Membrane Transport Proteins / Q000235:genetics*; D005260:Female; D005838:Genotype; D006579:Heterozygote; D006801:Humans; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology*; D011110:Polymorphism, Genetic; D013037:Spatial Behavior; D014705:Verbal Behavior; D055815:Young Adult
D050483:Dopamine Plasma Membrane Transport Proteins; C493214:SLC6A3 protein, human