[Progress in fundamental research: perspectives of cardiology].
Recent research performed in the Cardiology Research Center (CRC) and on-going studies reviewed in the article confirm the hypothesis suggested by CRC investigators about the role of a damaging action of some reactions in the body. The damage to the cell and subcell structures is done by such substances as malonic dialdehyde, methylglyoxal, active oxygen forms (nitric oxide and others). This damage can be used in diagnosis and treatment of cardiovascular diseases. A group of peptides, neuropeptide FF and its receptors in particular, are studied for regulation of the vascular tonicity and perspectives of practical application. As a result of the study of genes associated with cardiovascular diseases mixoma markers were found providing a 100% accurate diagnosis.
Chazov
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D000073861:Apelin; D015415:Biomarkers / Q000378:metabolism; D002309:Cardiology / Q000639:trends*; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism* / Q000628:therapy; D004730:Endothelium, Vascular / Q000378:metabolism; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D008315:Malondialdehyde / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism; D009842:Oligopeptides / Q000378:metabolism; D011765:Pyruvaldehyde / Q000378:metabolism; D018013:Receptors, Neuropeptide / Q000378:metabolism; D012426:Russia
C115436:APLN protein, human; D000073861:Apelin; D015415:Biomarkers; D036341:Intercellular Signaling Peptides and Proteins; D009842:Oligopeptides; D018013:Receptors, Neuropeptide; D009569:Nitric Oxide; D008315:Malondialdehyde; D011765:Pyruvaldehyde; C053651:phenylalanyl-leucyl-phenylalanyl-glutaminyl-prolyl-glutaminyl-arginyl-phenylalaninamide