title: [Effect of SspA on the formation of bacterial biofilm covering the surfaces of cardiovascular biomaterial Dacron].
abstract: This study sought to assess the effect of SspA on the formation of Staphylococcus aureus biofilm extending over the surfaces of Cardiovascular Biomaterial Dacron. SspA was extracted from the surface of staphylococcus aureus biofilm, purified, and then used to influence the adhesion of Staphylococcus aureus and the formation of Staphylococcus aureus biofilm on Dacron biomaterial surfaces. The formation of the Staphylococcus aureus biofilm on cardiovascular biomaterial Dacron surfaces under gradient SspA concentrations was evaluated by confocal laser microscopy. The result revealed that SspA inhibited the formation of Staphylococcus aureus biofilms on cardiovascular biomaterials surfaces effectively, and it was dose dependent. This study indicates that SspA is effective for preventing biomaterial centered infection and this method is conducive to clinical applications.
authors.affiliation: Department of Thoracic Surgery, Fujian Provincial Hospital, Fuzhou 350001, China. smlinxing@netease.com
authors.forename: Xing
authors.initials: X
authors.lastname: Lin
authors.forename: Yunchao
authors.initials: Y
authors.lastname: Huang
authors.forename: Liang
authors.initials: L
authors.lastname: Zhang
authors.forename: Dakuan
authors.initials: D
authors.lastname: Yang
authors.forename: Guoxing
authors.initials: G
authors.lastname: Weng
mesh_terms: D001422:Bacterial Adhesion; D001672:Biocompatible Materials / Q000737:chemistry; D018441:Biofilms / Q000254:growth & development*; D011093:Polyethylene Terephthalates; D016459:Prosthesis-Related Infections / Q000382:microbiology; D012697:Serine Endopeptidases / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000472:pathogenicity / Q000502:physiology
chemical_list: D001672:Biocompatible Materials; D011093:Polyethylene Terephthalates; D012697:Serine Endopeptidases; C028344:glutamyl endopeptidase