title: Effects of drug solubility on the release kinetics of water soluble and insoluble drugs from HPMC based matrix formulations.
abstract: The purpose of the present research work was to observe the effects of drug solubility on their release kinetics of water soluble verpamil hydrochloride and insoluble aceclofenac from hydrophilic polymer based matrix formulations. Matrix formulations were prepared by the direct compression method. The formulations were evaluated for various physical parameters. Along with the dynamics of water uptake and erosion, SEM and in vitro drug release of the tablets were studied. Applying an exponential equation, it was found that the kinetics of soluble drug release followed anomalous non-Fickian diffusion transport whereas insoluble drug showed zero-order release. SEM study showed pore formation on the tablet surface that differed depending on drug solubility. t-Test pointed to a significant difference in amount of both drugs released due to the difference in solubility. Solubility of the drug effects kinetics and the mechanism of drug release.
authors.affiliation: P.G. Department of Pharmaceutics, College of Pharmaceutical Sciences, Berhampur-760002 Orissa, India. santanu_nil@rediffmail.com
authors.forename: Santanu
authors.initials: S
authors.lastname: Chakraborty
authors.forename: Madhusmruti
authors.initials: M
authors.lastname: Khandai
authors.forename: Anuradha
authors.initials: A
authors.lastname: Sharma
authors.forename: Ch Niranjan
authors.initials: ChN
authors.lastname: Patra
authors.forename: V Jagannath
authors.initials: VJ
authors.lastname: Patro
authors.forename: Kalyan Kumar
authors.initials: KK
authors.lastname: Sen
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000379:methods; D003692:Delayed-Action Preparations; D004008:Diclofenac / Q000031:analogs & derivatives / Q000737:chemistry / Q000493:pharmacokinetics; D065347:Hypromellose Derivatives; D008747:Methylcellulose / Q000031:analogs & derivatives* / Q000737:chemistry / Q000493:pharmacokinetics; D012995:Solubility; D013607:Tablets; D014700:Verapamil / Q000737:chemistry / Q000493:pharmacokinetics; D014867:Water / Q000737:chemistry / Q000378:metabolism*
chemical_list: D003692:Delayed-Action Preparations; D013607:Tablets; D014867:Water; D004008:Diclofenac; D065347:Hypromellose Derivatives; D008747:Methylcellulose; D014700:Verapamil; C056498:aceclofenac