The influence of a hydrogen peroxide and glycerol containing mouthrinse on plaque accumulation: a 3-day non-brushing model.
OBJECTIVE
To evaluate the inhibition of plaque growth by an experimental mouthrinse (BioXyl) based on hydrogen peroxide/glycerol.


METHODS
It was a double-blind, randomized study involving 40 volunteers in good general health. At the start of the trial, all participants received a dental prophylaxis to remove all plaque deposits. During the next 3 days subjects refrained from any mechanical oral hygiene procedure, except for the allocated mouthrinse being either the hydrogen peroxide (H(2)O(2); 0.013% H(2)O(2)/0.004% glycerol) or the placebo without H(2)O(2). At the third day of appointment, plaque levels were assessed at six sites per tooth.


RESULTS
The test group had a mean overall plaque score of 2.66 and the placebo group of 2.70. The difference in plaque scores between the two groups was not statistically significant.


CONCLUSIONS
The results of this pilot study showed that there was no statistically significant difference between the H(2)O(2)/glycerol group and the placebo group with respect to plaque inhibition within this study design.
Hoenderdos
N L
NL
Department of Periodontology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, Amsterdam, The Netherlands. N.Hoenderdos@acta.nl
Rosema
N A M
NA
Slot
D E
DE
Timmerman
M F
MF
van der Velden
U
U
van der Weijden
G A
GA
D003773:Dental Plaque / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005990:Glycerol / Q000627:therapeutic use*; D006801:Humans; D006861:Hydrogen Peroxide / Q000627:therapeutic use*; D009067:Mouthwashes / Q000627:therapeutic use*; D012016:Reference Values; D016896:Treatment Outcome
D009067:Mouthwashes; D006861:Hydrogen Peroxide; D005990:Glycerol