A case of epidermolysis bullosa acquisita with unusual clinical features.
A 30-year-old woman developed epidermolysis bullosa acquisita (EBA) with unusual clinical features. Initially, only prurigo-like nodules were seen, which lasted for > 2 years and then blisters appeared. Eruptions resembling the rash in systemic lupus erythematosus were also seen on the face. Histopathological examination of a biopsy specimen revealed subepidermal blisters containing eosinophils and neutrophils. Direct immunofluorescence examination, indirect immunofluorescence examination using skin split with 1 mol/L sodium chloride, and immunoblotting analysis using extracts of normal human dermis gave results compatible with EBA. This case shows that EBA can present with nodular lesions as seen in pemphigoid nodularis or epidermolysis bullosa pruriginosa.
Furukita
K
K
Division of Dermatology, Department of Pathologic Medicine for Cutaneo-Motoric System, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan.
Ansai
S
S
Hida
Y
Y
Kubo
Y
Y
Arase
S
S
Hashimoto
T
T
D000328:Adult; D001323:Autoantibodies / Q000378:metabolism; D003622:Dapsone / Q000008:administration & dosage; D003879:Dermatologic Agents / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D016107:Epidermolysis Bullosa Acquisita / Q000188:drug therapy / Q000473:pathology*; D005260:Female; D019085:Fluorescent Antibody Technique, Direct; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism; D011239:Prednisolone / Q000008:administration & dosage
D001323:Autoantibodies; D003879:Dermatologic Agents; D007074:Immunoglobulin G; D003622:Dapsone; D011239:Prednisolone