Cerebellar degeneration and ocular myasthenia gravis in a patient with recurring ovarian carcinoma.
Myasthenia gravis (MG) and paraneoplastic cerebellar degeneration (PCD) are immune-mediated syndromes that can represent paraneoplastic disorders. We report a patient with history of ovarian carcinoma that presented with ptosis, diplopia and gait ataxia. Neurophysiological examination and laboratory tests revealed the presence of MG and PCD. An integrated FDG-PET/contrast-enhanced CT scan showed tumor recurrence. This is to the best of our knowledge the first association of MG and PCD with recurring ovarian carcinoma.
Caliandro
Pietro
P
Neurology Department, Istituto di Neurologia, Università Cattolica del Sacro Cuore, Pol. A: Gemelli Largo Gemelli 8, 00168, Rome, Italy. p.caliandro@rm.unicatt.it
Luigetti
Marco
M
Ricci
Enzo
E
Mirabella
Massimiliano
M
Tonali
Pietro Attilio
PA
Padua
Luca
L
D000368:Aged; D002277:Carcinoma / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D006801:Humans; D009157:Myasthenia Gravis / Q000000981:diagnostic imaging / Q000473:pathology*; D009364:Neoplasm Recurrence, Local; D010051:Ovarian Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D020362:Paraneoplastic Cerebellar Degeneration / Q000000981:diagnostic imaging / Q000473:pathology*; D049268:Positron-Emission Tomography; D014057:Tomography, X-Ray Computed