Rapid discovery of triazolobenzylidene-thiazolopyrimidines (TBTP) as CDC25 phosphatase inhibitors by parallel click chemistry and in situ screening.
Duval
Romain
R
Universite Paul Sabatier Toulouse III, Faculte des Sciences Pharmaceutiques, Laboratoire de Pharmacochimie des Substances Naturelles et Pharmacophores Redox, UMR152 IRD-UT3, 31062 Toulouse cedex 09, France. romain.duval@ird.fr
Kolb
Stéphanie
S
Braud
Emmanuelle
E
Genest
David
D
Garbay
Christiane
C
D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D004353:Drug Evaluation, Preclinical; D004791:Enzyme Inhibitors / Q000032:analysis* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D011743:Pyrimidines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D014230:Triazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D020687:cdc25 Phosphatases / Q000037:antagonists & inhibitors*
D004791:Enzyme Inhibitors; D011743:Pyrimidines; D013844:Thiazoles; D014230:Triazoles; D020687:cdc25 Phosphatases