Renal AA amyloidosis secondary to morbid obesity?
Systemic amyloidosis is characterized by extracellular deposits on different organs of insoluble fibrils compounded of low molecular weight subunits coming from a great diversity of serum proteins. Secondary amyloidosis AA is due to fibril deposition composed of fragments of the acute phase reactant serum amyloid A. We report a case of a young patient with morbid obesity and hypertension who was admitted to our hospital for acute renal insufficiency associated with nephrotic range proteinuria which developed while on antibiotic treatment for a respiratory infection. AA Amyloidosis was diagnosed by renal biopsy. Based on recent evidence we hypothesize that morbid obesity could be the underlying cause of the deposit disease.
Alsina
E
E
Hospital Universitari Arnau de Vilanova, Lleida, Spain.
Martin
M
M
Panadés
Mj
M
Fernández
E
E
D000328:Adult; D000686:Amyloidosis / Q000209:etiology*; D001706:Biopsy; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000209:etiology*; D009767:Obesity, Morbid / Q000150:complications*; D012307:Risk Factors