title: Therapy and outcome of suspected alpha lipoic acid toxicity in two dogs.
abstract: OBJECTIVE
  To report a suspected toxicity in 2 dogs; to discuss therapy and prognosis.
  
  
  METHODS
  Suspected alpha lipoic acid (ALA) toxicity was diagnosed based on clinical history and compatible laboratory findings in 2 dogs. Case 1 was presented within 10 hours of ALA ingestion, with initial behavioral changes likely due to hypoglycemia. During the course of hospitalization, hypoglycemia persisted and evidence of acute hepatic insult developed. With aggressive supportive care (including IV fluids with dextrose supplementation, hepatoprotective medications, and a plasma transfusion), he made a full recovery. Case 2 was presented approximately 60 hours after ALA ingestion, and was found to be in oliguric renal failure. She was treated with IV fluids, gastroprotective medications, and furosemide, but her condition deteriorated and she was ultimately euthanized within 16 hours of admission to the hospital.
  
  
  CONCLUSIONS
  ALA is an uncommon but serious toxin that should be considered in cases presenting with hypoglycemia, acute renal failure, or acute hepatic insult.
authors.affiliation: DoveLewis Emergency Animal Hospital, Portland, OR97209, USA. eloftin@dovelewis.org
authors.forename: Erika G
authors.initials: EG
authors.lastname: Loftin
authors.forename: Lee V
authors.initials: LV
authors.lastname: Herold
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000139:chemically induced* / Q000628:therapy; D004285:Dogs; D005260:Female; D008297:Male; D008063:Thioctic Acid / Q000506:poisoning*
chemical_list: D008063:Thioctic Acid