title: The assessment of regional gut transit times in healthy controls and patients with gastroparesis using wireless motility technology.
abstract: BACKGROUND
  Wireless pH and pressure motility capsule (wireless motility capsule) technology provides a method to assess regional gastrointestinal transit times.
  
  
  OBJECTIVE
  To analyse data from a multi-centre study of gastroparetic patients and healthy controls and to compare regional transit times measured by wireless motility capsule in healthy controls and gastroparetics (GP).
  
  
  METHODS
  A total of 66 healthy controls and 34 patients with GP (15 diabetic and 19 idiopathic) swallowed wireless motility capsule together with standardized meal (255 kcal). Gastric emptying time (GET), small bowel transit time (SBTT), colon transit time (CTT) and whole gut transit time (WGTT) were calculated using the wireless motility capsule.
  
  
  RESULTS
  Gastric emptying time, CTT and WGTT but not SBTT were significantly longer in GP than in controls. Eighteen percent of gastroparetic patients had delayed WGTT. Both diabetic and idiopathic aetiologies of gastroparetics had significantly slower WGTT (P < 0.0001) in addition to significantly slower GET than healthy controls. Diabetic gastroparetics additionally had significantly slower CTT than healthy controls (P = 0.0054).
  
  
  CONCLUSIONS
  In addition to assessing gastric emptying, regional transit times can be measured using wireless motility capsule. The prolongation of CTT in gastroparetic patients indicates that dysmotility beyond the stomach in GP is present, and it could be contributing to symptom presentation.
authors.affiliation: Center for Gastrointestinal Nerve & Muscle Function & GI Motility, University of Kansas Medical Center, Kansas City, USA. Irene.sarosiek@ttuhsc.edu
authors.forename: I
authors.initials: I
authors.lastname: Sarosiek
authors.forename: K H
authors.initials: KH
authors.lastname: Selover
authors.forename: L A
authors.initials: LA
authors.lastname: Katz
authors.forename: J R
authors.initials: JR
authors.lastname: Semler
authors.forename: G E
authors.initials: GE
authors.lastname: Wilding
authors.forename: J M
authors.initials: JM
authors.lastname: Lackner
authors.forename: M D
authors.initials: MD
authors.lastname: Sitrin
authors.forename: B
authors.initials: B
authors.lastname: Kuo
authors.forename: W D
authors.initials: WD
authors.lastname: Chey
authors.forename: W L
authors.initials: WL
authors.lastname: Hasler
authors.forename: K L
authors.initials: KL
authors.lastname: Koch
authors.forename: H P
authors.initials: HP
authors.lastname: Parkman
authors.forename: J
authors.initials: J
authors.lastname: Sarosiek
authors.forename: R W
authors.initials: RW
authors.lastname: McCallum
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D053704:Capsule Endoscopy / Q000379:methods*; D003106:Colon / Q000502:physiology*; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects / Q000502:physiology*; D005772:Gastrointestinal Transit / Q000502:physiology*; D018589:Gastroparesis / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000379:methods