title: Rapid clinical progression to AIDS and death in a persistently seronegative HIV-1 infected heterosexual young man.
abstract: Seronegative HIV-1 infection has important implications for diagnosis and prevention. We describe a case of HIV-1 infection without seroconversion and fast progression to AIDS and death.Genetic and phylogenetic analysis indicated that the patient was infected with a CRF14_BG-like strain selectively transmitted by his seropositive sexual partner. The results suggest a massive infection with a highly aggressive CRF14_BG-like strain and/or the presence of an unidentified immunological deficiency that has prevented the formation of HIV-1-specific antibodies.
authors.affiliation: Unidade dos Retrovírus e Infecções Associadas, Centro de Patogénese Molecular, Faculdade de Farmácia de Lisboa, Lisbon.
authors.forename: Inês
authors.initials: I
authors.lastname: Bártolo
authors.forename: Ricardo
authors.initials: R
authors.lastname: Camacho
authors.forename: Helena
authors.initials: H
authors.lastname: Barroso
authors.forename: Victor
authors.initials: V
authors.lastname: Bezerra
authors.forename: Nuno
authors.initials: N
authors.lastname: Taveira
mesh_terms: D018450:Disease Progression; D017809:Fatal Outcome; D006679:HIV Seropositivity / Q000821:virology*; D015497:HIV-1; D006801:Humans; D008297:Male; D016017:Odds Ratio; D012307:Risk Factors; D012725:Sexual Behavior; D012747:Sexual Partners; D055815:Young Adult