title: Lymphoma in 3 related Rottweilers from a single household.
abstract: Over a period of approximately 1 year, 2 sibling Rottweilers and their dam in the same household developed stage IV and stage III lymphoma, respectively. All 3 initially responded to doxorubicin chemotherapy but relapsed after approximately 3 months and were subsequently euthanased. As no obvious environmental trigger could be identified in these dogs, it is speculated that an underlying genetic predisposition could have played a role in the development of lymphoma in these related dogs.
authors.affiliation: Bryanston Veterinary Hospital, PO Box 67092, Bryanston 2021, South Africa. rlobetti@mweb.co.za
authors.forename: R G
authors.initials: RG
authors.lastname: Lobetti
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy / Q000235:genetics*; D004285:Dogs; D004317:Doxorubicin / Q000627:therapeutic use*; D017809:Fatal Outcome; D005260:Female; D020022:Genetic Predisposition to Disease; D008223:Lymphoma / Q000188:drug therapy / Q000235:genetics / Q000662:veterinary*; D010375:Pedigree
chemical_list: D000903:Antibiotics, Antineoplastic; D004317:Doxorubicin