Immunological and biochemical correlates of adjunctive dexamethasone in Vietnamese adults with bacterial meningitis.
Adjunctive treatment to improve outcome from bacterial meningitis has centered on dexamethasone. Among Vietnamese patients with bacterial meningitis, cerebrospinal fluid (CSF) opening pressure and CSF:plasma glucose ratios were significantly improved and levels of CSF cytokines interleukin (IL)-6, IL-8, and IL-10 and were all statistically significantly lower after treatment in patients who were randomized to dexamethasone, compared with levels in patients who received placebo.
Mai
Nguyen Thi Hoang
NT
Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.
Tuan
Trung Vu
TV
Wolbers
Marcel
M
Hoang
Dang Minh
DM
Nga
Tran Vu Thieu
TV
Chau
Tran Thi Hong
TT
Chuong
Ly Van
LV
Sinh
Dinh Xuan
DX
Nghia
Ho Dang Trung
HD
Phong
Nguyen Duy
ND
Phu
Nguyen Hoan
NH
Diep
To Song
TS
Hang
Hoang Thi Thanh
HT
Chau
Nguyen van Vinh
Nv
Farrar
Jeremy
J
Schultsz
Constance
C
Hien
Tran Tinh
TT
Simmons
Cameron P
CP
D000293:Adolescent; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D044466:Asian People; D002648:Child; D003907:Dexamethasone / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000134:cerebrospinal fluid; D015850:Interleukin-6 / Q000134:cerebrospinal fluid; D016209:Interleukin-8 / Q000134:cerebrospinal fluid; D008297:Male; D016920:Meningitis, Bacterial / Q000134:cerebrospinal fluid* / Q000188:drug therapy*; D008875:Middle Aged; D014744:Vietnam; D055815:Young Adult
D000893:Anti-Inflammatory Agents; D015850:Interleukin-6; D016209:Interleukin-8; D016753:Interleukin-10; D003907:Dexamethasone