title: The prevalence of CYP2C19 mutations in Turkish patients with dyspepsia.
abstract: OBJECTIVE
  We aimed to determine the distribution of cytochrome P450 2C19 (CYP2C19) genotype frequencies in Turkish patients with dyspepsia.
  
  
  METHODS
  CYP2C19 genotype was determined in 100 Turkish patients with dyspepsia. DNA of the patients was isolated from whole blood and genotypes were detected by specific probes in real-time polymerase chain reaction (PCR).
  
  
  RESULTS
  The frequencies of heterozygous CYP2C19*2 and CYP2C19*3 genotypes were 13% and 1% in dyspeptic patients, respectively. Homozygous mutant CYP2C19*2 was detected at a rate of only 1% in the study population, and homozygous mutant genotype of CYP2C19*3 was not found. The frequencies of homozygous CYP2C19*2 and CYP2C19*3 genotypes were 86% and 99% in dyspeptic Turkish patients, respectively.
  
  
  CONCLUSIONS
  This is the first study investigating CYP2C19 polymorphism in dyspeptic Turkish patients. Our investigation revealed that the most common CYP2C19 genotype was wild type CYP2C19 in dyspeptic Turkish patients. Dyspeptic Turkish patients are extensive metabolizers for proton pump inhibitors. This finding might have impact on the clinical consequences for the treatment strategies in dyspepsia.
authors.affiliation: Kocaeli University, Faculty of Medicine Division of Gastroenterology 41380, Umuttepe, Kocaeli, Turkey. altaycelebi@yahoo.com
authors.forename: Altay
authors.initials: A
authors.lastname: Celebi
authors.forename: Orhan
authors.initials: O
authors.lastname: Kocaman
authors.forename: Hakan
authors.initials: H
authors.lastname: Savli
authors.forename: Cem
authors.initials: C
authors.lastname: Aygün
authors.forename: Buğra Tolga
authors.initials: BT
authors.lastname: Konduk
authors.forename: Omer
authors.initials: O
authors.lastname: Sentürk
authors.forename: Sadettin
authors.initials: S
authors.lastname: Hülagu
mesh_terms: D000328:Adult; D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics*; D065731:Cytochrome P-450 CYP2C19; D004415:Dyspepsia / Q000453:epidemiology* / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D005838:Genotype; D006720:Homozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D014421:Turkey / Q000453:epidemiology; D055815:Young Adult
chemical_list: D001189:Aryl Hydrocarbon Hydroxylases; C045793:CYP2C19 protein, human; D065731:Cytochrome P-450 CYP2C19