[Nuclear actin].
Actin is multifunctional protein occurring in all eukaryotic cells. It appears in cytoplasm and in nucleus. Organization and functions of nuclear actin are not well recognized to distinguish from cytoplasmic actin. Actin monomers are shuttling between cytoplasm and nucleus, integrating both of those compartments. Monomers, oligomers and short polimers are observed as the result of the limited space within the nucleus. Actin participates in nuclear structure organization, chromatin remodeling, transcription and signal transduction. Nuclear actin level, organization and functions are under control of ABPs (similarly as it takes place in cytoplasm), including some proteins appearing only in the nucleus.
Migocka-Patrzałek
Marta
M
Zakład Patologii Komórki, Wydział Biotechnologii, Uniwersytet Wrocławski, Wrocław. migocka@ibmb.uni.wroc.pl
Malicka-Błaszkiewicz
Maria
M
D000199:Actins / Q000378:metabolism*; D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D042002:Chromatin Assembly and Disassembly / Q000502:physiology; D006801:Humans; D008840:Microfilament Proteins / Q000378:metabolism; D015398:Signal Transduction; D014158:Transcription, Genetic / Q000502:physiology
D000199:Actins; D008840:Microfilament Proteins