Lower limb high arterial flow induced by tenofovir and emtricitabine treatment.
Here, we describe a case of an HIV-infected patient with right lower limb oedema that appeared after initiation of tenofovir and emtricitabine treatment. The patient was fully investigated by serial heart and vessel echo-Doppler examination. Oedema of the lower limb was attributed to a transient drug-induced fivefold increase in peripheral artery flow, which was induced by a reduction in peripheral arterial resistance. The possible mechanisms of disease are discussed.
Periard
Daniel
D
Service of Angiology and Medicine, Hopital Cantonal, Fribourg, Switzerland. periardd@h-fr.ch
Yerly
Patrick
P
Hayoz
Daniel
D
Mazzolai
Lucia
L
Widmeier
Arnaud
A
Cavassini
Matthias
M
D000225:Adenine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000328:Adult; D001783:Blood Flow Velocity / Q000187:drug effects*; D003841:Deoxycytidine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004487:Edema / Q000139:chemically induced / Q000473:pathology; D000068679:Emtricitabine; D015658:HIV Infections / Q000188:drug therapy; D006801:Humans; D007866:Leg / Q000098:blood supply; D008297:Male; D063065:Organophosphonates / Q000009:adverse effects* / Q000627:therapeutic use*; D000068698:Tenofovir
D063065:Organophosphonates; D003841:Deoxycytidine; D000068698:Tenofovir; D000068679:Emtricitabine; D000225:Adenine