Deceptively simple but simply deceptive--Caenorhabditis elegans lifespan studies: considerations for aging and antioxidant effects.
The nematode worm Caenorhabditis elegans (C. elegans) is increasingly popular as a model organism for aging studies as well as for testing antioxidants and other compounds for effects on longevity. However, results in the literature are sometimes confusing and contradictory. This review introduces C. elegans as a model organism, discusses aspects that make it attractive for aging and antioxidant research, and addresses some problems and potential artifacts.
Gruber
Jan
J
Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Ng
Li Fang
LF
Poovathingal
Suresh Kumar
SK
Halliwell
Barry
B
D000375:Aging / Q000187:drug effects / Q000502:physiology; D000818:Animals; D000975:Antioxidants / Q000378:metabolism* / Q000494:pharmacology; D017173:Caenorhabditis elegans / Q000502:physiology*; D006801:Humans; D008017:Life Expectancy; D008136:Longevity / Q000187:drug effects
D000975:Antioxidants