A case of imipramine-associated immune thrombocytopenia.
Drug-induced immune thrombocytopenia (DITP), excluding heparin-induced thrombocytopenia, is relatively uncommon. It is characterized by drug-dependent antibodies that bind to the platelets and cause their destruction when the responsible drug is ingested or injected. Imipramine is a tricyclic antidepressant drug that is one of those used widely for primary enuresis nocturna, attention deficit hyperactivity disorder, depression, and anxiety disorder in children and adolescents. Imipramine rarely causes hematological abnormalities. A five-year-old boy with imipramine-associated antiglobulin-positive immune thrombocytopenia is reported herein, and we also discuss the possible pathogenesis of drug-associated thrombocytopenia.
Aksoy
Ayşe
A
Department of Pediatrics, Karadeniz Technical University Faculty of Medicine, Trabzon, Turkey.
Erduran
Erol
E
Gedik
Yusuf
Y
D000929:Antidepressive Agents, Tricyclic / Q000008:administration & dosage / Q000009:adverse effects*; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy; D002675:Child, Preschool; D003298:Coombs Test; D006801:Humans; D007099:Imipramine / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D010976:Platelet Count; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000139:chemically induced* / Q000175:diagnosis
D000929:Antidepressive Agents, Tricyclic; D007099:Imipramine