[Enhancing effect of androgen receptor antagonist on gonadotropic inductors of ovulation in rats with polycystic ovaries].
Hormonal indices, phase pattern of estrous cycles, and histological structure of the ovaries were studied in female rats with polycystic ovaries caused by subcutaneous implantation of Silastic capsules with testosterone after consecutive treatment with non-steroid antiandrogen, flutamide (flutafarm), urinary FSH (menopur) and HCG (choragon). It was shown that while the plasma testosterone level was increased, administration of the drugs in subtherapeutical doses interrupted persistent diestrus, renewed estrous cycle, gonadal and uterine weights, induced appearance of postovulatory luteal bodies and restored fertility. Therefore, antiandrogen potentiation of pharmnnaco-dynamic effect of the gonadotropins with regard to their ability to ovulation induction was found out.
Reznikov
O H
OH
Borys
O M
OM
Nosenko
N D
ND
Sinitsyn
P V
PV
Tarasenko
L V
LV
Poliakova
L I
LI
D000726:Androgen Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D059002:Androgen Receptor Antagonists; D000818:Animals; D000858:Anovulation / Q000097:blood / Q000209:etiology / Q000378:metabolism; D006063:Chorionic Gonadotropin / Q000008:administration & dosage / Q000494:pharmacology; D004195:Disease Models, Animal; D004971:Estrus / Q000187:drug effects / Q000378:metabolism; D005260:Female; D005300:Fertility Agents, Female / Q000008:administration & dosage / Q000494:pharmacology*; D005485:Flutamide / Q000008:administration & dosage / Q000494:pharmacology; D008596:Menotropins / Q000008:administration & dosage / Q000494:pharmacology; D010060:Ovulation / Q000097:blood / Q000187:drug effects* / Q000378:metabolism; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000150:complications / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D011967:Receptors, Gonadotropin / Q000378:metabolism*; D013739:Testosterone / Q000097:blood
D000726:Androgen Antagonists; D059002:Androgen Receptor Antagonists; D006063:Chorionic Gonadotropin; D005300:Fertility Agents, Female; D011967:Receptors, Gonadotropin; D013739:Testosterone; D008596:Menotropins; D005485:Flutamide