Design and characteristics of holographic neural photo-stimulation systems.
Computer-generated holography is an emerging technology for stimulation of neuronal populations with light patterns. A holographic photo-stimulation system may be designed as a powerful research tool or a compact neural interface medical device, such as an optical retinal prosthesis. We present here an overview of the main design issues including the choice of holographic device, field-of-view, resolution, physical size, generation of two- and three-dimensional patterns and their diffraction efficiency, choice of algorithms and computational effort. The performance and characteristics of a holographic pattern stimulation system with kHz frame rates are demonstrated using experimental recordings from isolated retinas.
Golan
L
L
Faculty of Biomedical Engineering, The Technion-I.I. T., Haifa, Israel.
Reutsky
I
I
Farah
N
N
Shoham
S
S
D000465:Algorithms; D001331:Automation; D004582:Electronics, Medical / Q000295:instrumentation* / Q000379:methods*; D004867:Equipment Design; D006696:Holography / Q000295:instrumentation* / Q000379:methods*; D006801:Humans; D008027:Light; D008853:Microscopy / Q000295:instrumentation / Q000379:methods; D055616:Microtechnology / Q000295:instrumentation / Q000379:methods; D009474:Neurons / Q000502:physiology*; D055095:Optics and Photonics / Q000295:instrumentation / Q000379:methods; D010775:Photic Stimulation; D012160:Retina / Q000502:physiology; D012815:Signal Processing, Computer-Assisted; D013997:Time Factors; D014584:User-Computer Interface