title: Single fraction spine radiosurgery for myeloma epidural spinal cord compression.
abstract: Radiosurgery delivers highly focused radiation beams to the defined target with high precision and accuracy. It has been demonstrated that spine radiosurgery can be safely used for treatment of spine metastasis with rapid and durable pain control, but without detrimental effects to the spinal cord. This study was carried out to determine the role of single fraction radiosurgery for epidural spinal cord compression due to multiple myeloma. A total of 31 lesions in 24 patients with multiple myeloma, who presented with epidural spinal cord compression, were treated with spine radiosurgery. Single fraction radiation dose of 10-18 Gy (median of 16 Gy) was administered to the involved spine including the epidural or paraspinal tumor. Patients were followed up with clinical exams and imaging studies. Median follow-up was 11.2 months (range 1-55). Primary endpoints of this study were pain control, neurological improvement, and radiographic tumor control. Overall pain control rate was 86%; complete relief in 54%, and partial relief in 32% of the patients. Seven patients presented with neurological deficits. Five patients neurologically improved or became normal after radiosurgery. Complete radiographic response of the epidural tumor was noted in 81% at 3 months after radiosurgery. During the follow-up time, there was no radiographic or neurological progression at the treated spine. The treatment was non-invasive and well tolerated. Single fraction radiosurgery achieved an excellent clinical and radiographic response of myeloma epidural spinal cord compression. Radiosurgery can be a viable treatment option for myeloma epidural compression.
authors.affiliation: Department of Radiation Oncology, Henry Ford Hospital, Detroit, MI 48202, USA.
authors.forename: Ryan
authors.initials: R
authors.lastname: Jin
authors.forename: Jack
authors.initials: J
authors.lastname: Rock
authors.forename: Jian-Yue
authors.initials: JY
authors.lastname: Jin
authors.forename: Nalini
authors.initials: N
authors.lastname: Janakiraman
authors.forename: Jae Ho
authors.initials: JH
authors.lastname: Kim
authors.forename: Benjamin
authors.initials: B
authors.lastname: Movsas
authors.forename: Samuel
authors.initials: S
authors.lastname: Ryu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004824:Epidural Space; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications*; D016634:Radiosurgery / Q000009:adverse effects / Q000379:methods*; D013117:Spinal Cord Compression / Q000601:surgery*; D013131:Spine / Q000601:surgery*