title: P-selectin glycoprotein ligand-1 plays a crucial role in the selective recruitment of leukocytes into the atherosclerotic arterial wall.
abstract: Leukocyte recruitment to the arterial vessel wall is the first step in the development of atherosclerotic lesions. Leukocyte homing in this event proceeds through a well-defined adhesion cascade, which includes tethering, rolling, adhesion, and transmigration. Selectins, including the P-, E-, and L-selectins, and their ligands mediate the initial tethering and rolling. Interactions between selectins and their ligands serve as a braking system to decelerate fast-flowing leukocytes from the central blood stream and enable them to adhere to and transmigrate underneath the activated endothelium. The best characterized ligand for selectins is P-selectin glycoprotein ligand-1, an extended homodimeric mucin on leukocytes that binds to all three selectins. Recent studies show that differential expression or glycosylation of P-selectin glycoprotein ligand-1 in different leukocytes mediates selective recruitment of different subsets of monocytes or lymphocytes to atherosclerotic arteries.
authors.affiliation: Department of Medicine, University of Minnesota Medical School, Minneapolis, MN 55455, USA. yuqing@umn.edu
authors.forename: Yuqing
authors.initials: Y
authors.lastname: Huo
authors.forename: Lijun
authors.initials: L
authors.lastname: Xia
mesh_terms: D000818:Animals; D001158:Arteries / Q000276:immunology*; D050197:Atherosclerosis / Q000276:immunology*; D002448:Cell Adhesion; D004730:Endothelium, Vascular / Q000276:immunology; D006031:Glycosylation; D006801:Humans; D007249:Inflammation / Q000276:immunology; D018836:Inflammation Mediators / Q000378:metabolism; D036904:Leukocyte Rolling; D007962:Leukocytes / Q000276:immunology*; D008024:Ligands; D008562:Membrane Glycoproteins / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D019087:Selectins / Q000378:metabolism*
chemical_list: D018836:Inflammation Mediators; D008024:Ligands; D008562:Membrane Glycoproteins; C084882:P-selectin ligand protein; D019087:Selectins