title: Effects of 12-month tadalafil therapy for erectile dysfunction on couple relationships: results from the DETECT study.
abstract: BACKGROUND
  Erectile dysfunction (ED) is distressing and can affect a couple's relationship.
  
  
  OBJECTIVE
  To investigate partner awareness of ED, relationship problems, and the effects of tadalafil treatment over 12 months.
  
  
  METHODS
  The Determinants of Continued Use of Tadalafil study is a prospective 12-month European observational study in patients with ED initiating or changing treatment to on-demand tadalafil. A total of 1,900 patients were enrolled in eight countries. Assessments were made on predefined treatment outcomes in a routine clinical setting.
  
  
  METHODS
  At baseline, 1, 6, and 12 months, patients were asked about relationship problems (unspecified), partner awareness and support of consultation, and partner sexual problems. Data were analyzed for patients continuing tadalafil at 12 months.
  
  
  RESULTS
  At baseline, 96% of patients had a partner, 80% of partners supported an ED consult, and 73% were aware of the consultation. Relationship problems were reported by 17% of patients at baseline. At 12 months, 84% of patients were still taking tadalafil. Of these, 19% reported relationship problems at baseline. After 12 months of treatment with tadalafil, 4% of patients still reported perceived problems. Factors associated with no relationship problems at 12 months were: at baseline, no previous ED treatment, partner in poor health; and at 12 months a lower ED severity. If the partner was felt to have a sexual problem at 12 months, relationship improvement was less likely. Further, 3% of patients developed relationship problems during treatment. Factors associated with developing a relationship problem were: a history of pelvic surgery at baseline, a different partner at 12 months than at baseline, and a partner with a sexual problem at 12 months.
  
  
  CONCLUSIONS
  Improvement of ED with tadalafil was associated with reduced relationship problems, suggesting that problems were associated with ED and resolved with treatment.
authors.affiliation: Andrology Unit, Department of Urology, Antwerp University Hospital, Antwerp, Belgium. benny.verheyden@uza.be
authors.forename: Benny
authors.initials: B
authors.lastname: Verheyden
authors.forename: Thierry
authors.initials: T
authors.lastname: Roumeguère
authors.forename: Alain
authors.initials: A
authors.lastname: Bitton
authors.forename: Mark
authors.initials: M
authors.lastname: Belger
authors.forename: Henry
authors.initials: H
authors.lastname: Schmitt
mesh_terms: D001364:Awareness; D002243:Carbolines / Q000627:therapeutic use*; D007172:Erectile Dysfunction / Q000188:drug therapy*; D005260:Female; D006304:Health Status; D006801:Humans; D007398:Interpersonal Relations; D008297:Male; D008875:Middle Aged; D058986:Phosphodiesterase 5 Inhibitors; D010726:Phosphodiesterase Inhibitors / Q000627:therapeutic use*; D012747:Sexual Partners; D011795:Surveys and Questionnaires; D000068581:Tadalafil; D013997:Time Factors
chemical_list: D002243:Carbolines; D058986:Phosphodiesterase 5 Inhibitors; D010726:Phosphodiesterase Inhibitors; D000068581:Tadalafil