[Analysis of 5'-leader regions in protozoa type Apicomplexa and red algae plastids].
Apicomplexan parasites contain the apicoplasts, a chloroplast-like organelle. By means of the multiple alignments of 5'-leader regions for the plastid-encoded genes, we found some conserved non-coding regions in the parasites as well as in red algae. We suppose these regions are the sites for interaction between the RNA and regulatory proteins. Conservative sites was found upstream gene ycf24, required for [Fe-S]-clasters development, and upstream some other genes. In particular, in Toxoplasma gondii a simultaneous regulation is predicted for three genes ycf24, rps4 and rpoB. Our prediction corresponds to the known data that T. gondii apicoplasts in its entirety are required for a short time only, but ones procure pathogenesis. Another site is predicted upstream gene rpoB, that encodes beta-subunit of the RNA polymerase, in red algae Porphyra spp. as well in Eimeria tenella and Theileria parva.
Sadovskaia
T A
TA
Selivestrov
A V
AV
D020121:5' Untranslated Regions / Q000235:genetics*; D000818:Animals; D016782:Apicomplexa / Q000235:genetics*; D017125:Genes, Protozoan / Q000235:genetics*; D018087:Plastids / Q000235:genetics*; D000461:Rhodophyta / Q000235:genetics*
D020121:5' Untranslated Regions