title: The effect of vitamin D replacement therapy on insulin resistance and androgen levels in women with polycystic ovary syndrome.
abstract: Insulin resistance (IR) is one of the common features of the polycystic ovary syndrome (PCOS), and recent studies indicate the possible role of vitamin D in the pathogenesis of IR and glucose metabolism. Aim of this study was aimed to determine the effect of vitamin D replacement therapy on glucose metabolism, insulin, and androgen levels in obese, insulin-resistant women with PCOS. Eleven women with PCOS were included in the study. Mean age of the patients was 23.6+/-5.7 yr, body mass index 33.9+/-5.1 kg/m(2). Six patients (54.5%) had acantosis nigricans and 10 (90.9%) oligoamenorrhea. The mean Ferriman Gallwey score was 14.1+/-4.6. Only 2 women were within the normal limits of vitamin D levels as >20 ng/ml. Three weeks after the administration of the single dose of 300,000 units of vitamin D3 orally, 25-hydroxyvitamin D3 significantly increased from 16.9+/-16 ng/ml to 37.1+/-14.6 ng/ml (p: 0.027) and only 2 women were detected to have vitamin D3 levels <20 ng/ml. Although glucose and insulin levels were decreased non-significantly, homeostasis model assessment (HOMA)-IR significantly decreased from 4.41+/-1.38 to 3.67+/-1.48 (p: 0.043). No significant alterations were witnessed at the levels of DHEAS, total and free testosterone, androstenedione. No correlation was found between vitamin D with HOMA and other hormonal parameters. In conclusion, women with PCOS have mostly insufficient vitamin D levels, and vitamin D replacement therapy may have a beneficial effect on IR in obese women with PCOS.
authors.affiliation: Division of Endocrinology, Malatya State Hospital, Malatya, Turkey.
authors.forename: H
authors.initials: H
authors.lastname: Selimoglu
authors.forename: C
authors.initials: C
authors.lastname: Duran
authors.forename: S
authors.initials: S
authors.lastname: Kiyici
authors.forename: C
authors.initials: C
authors.lastname: Ersoy
authors.forename: M
authors.initials: M
authors.lastname: Guclu
authors.forename: G
authors.initials: G
authors.lastname: Ozkaya
authors.forename: E
authors.initials: E
authors.lastname: Tuncel
authors.forename: E
authors.initials: E
authors.lastname: Erturk
authors.forename: S
authors.initials: S
authors.lastname: Imamoglu
mesh_terms: D000293:Adolescent; D000328:Adult; D000728:Androgens / Q000097:blood*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D005260:Female; D006801:Humans; D007328:Insulin / Q000378:metabolism; D007333:Insulin Resistance / Q000502:physiology*; D009765:Obesity / Q000378:metabolism; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000188:drug therapy*; D014807:Vitamin D / Q000627:therapeutic use*; D014815:Vitamins / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D000728:Androgens; D001786:Blood Glucose; D007328:Insulin; D014815:Vitamins; D014807:Vitamin D