title: Six-year experience: long-term disease control outcomes for partial breast irradiation using MammoSite balloon brachytherapy.
abstract: BACKGROUND
  This report describes estimated 4-year tumor bed and ipsilateral breast recurrence-free intervals, event-free survival, disease-specific survival, and overall survival in a cohort of MammoSite brachytherapy (MBT) patients with mature follow-up treated at a single institution over a 6-year period.
  
  
  METHODS
  An analysis of MBT cases was performed by using a prospectively collected quality-assurance database, departmental chart review, and electronic medical records. Patient-, tumor-, treatment-, and outcome-specific data were extracted and recorded into a research database. Patients were eligible for inclusion in this analysis if they were at least 6 months post-MBT.
  
  
  RESULTS
  From May 2002 through March 2008, 111 MBT patients have been treated and were eligible for the present analysis. With a median follow-up of 46 months, the estimated 4-year outcomes for the entire cohort were tumor bed control 99%, ipsilateral breast control 95%, event-free survival 88%, disease-specific survival 97%, and overall survival 92%.
  
  
  CONCLUSIONS
  The present study shows low rates of local and ipsilateral breast disease failure in a well-defined cohort of MBT patients with mature follow-up.
authors.affiliation: Department of Radiation Oncology, Medical University of South Carolina, Hollings Cancer Center, 169 Ashley Ave. MSC 318 Charleston, SC 29425, USA. harperjl@musc.edu
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Harper
authors.forename: John M
authors.initials: JM
authors.lastname: Watkins
authors.forename: A Jason
authors.initials: AJ
authors.lastname: Zauls
authors.forename: Amy E
authors.initials: AE
authors.lastname: Wahlquist
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Garrett-Mayer
authors.forename: Megan K
authors.initials: MK
authors.lastname: Baker
authors.forename: David J
authors.initials: DJ
authors.lastname: Cole
authors.forename: Anthony E
authors.initials: AE
authors.lastname: Dragun
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Jenrette
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001918:Brachytherapy / Q000295:instrumentation / Q000379:methods*; D001943:Breast Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D002404:Catheterization; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D015412:Mastectomy, Segmental; D008875:Middle Aged; D011446:Prospective Studies; D018714:Radiotherapy, Adjuvant / Q000379:methods; D016019:Survival Analysis