title: The effect of testosterone replacement therapy on bladder functions and histology in orchiectomized mature male rats.
abstract: OBJECTIVE
  To investigate the effect of testosterone replacement therapy on bladder functions and smooth muscle/collagen content in orchidectomized orchiectomized mature male rats.
  
  
  METHODS
  The study included 25 mature male Sprague-Dawley rats divided into 3 groups. After bilateral orchiectomy, 8 rats received intramuscular saline injection, as a control group, and 8 rats received intramuscular injection of testosterone undecanoate 100 mg/kg as a treatment group. The sham group had 9 rats. Urodynamic studies were performed in all groups, before and after the study. The rats were killed after 60 days, and cystometric findings and smooth muscle/collagen ratio of the bladders were compared between the groups.
  
  
  RESULTS
  From the beginning to the end of the experiment, mean maximal bladder capacity increased 46.61% +/- 20.82 in the testosterone treatment group, while decreased 38.91% +/- 17.83 in control group, revealing a significant difference (P = .002). Smooth muscle/collagen ratio was significantly higher in the testosterone treatment group (1.53 +/- .34) than in the control group (1.05 +/- .32), (P = .01).
  
  
  CONCLUSIONS
  This study showed that bladder capacity and smooth muscle/collagen content improved with testosterone therapy in orchiectomized rats. Therefore, testosterone replacement therapy in late-onset hypogonadal men with urogenital dysfunction may have a positive role to improve bladder function by increasing bladder smooth muscle.
authors.affiliation: Department of Urology, University of Mersin School of Medicine, Mersin, Turkey.
authors.forename: Mesut
authors.initials: M
authors.lastname: Tek
authors.forename: Ebru
authors.initials: E
authors.lastname: Balli
authors.forename: Burak
authors.initials: B
authors.lastname: Cimen
authors.forename: Ozan
authors.initials: O
authors.lastname: Efesoy
authors.forename: Izzet
authors.initials: I
authors.lastname: Oğuz
authors.forename: Selahittin
authors.initials: S
authors.lastname: Cayan
mesh_terms: D000818:Animals; D020249:Hormone Replacement Therapy; D008297:Male; D009919:Orchiectomy; D051381:Rats; D017207:Rats, Sprague-Dawley; D013739:Testosterone / Q000494:pharmacology*; D001743:Urinary Bladder / Q000166:cytology* / Q000187:drug effects / Q000502:physiology*
chemical_list: D013739:Testosterone