title: Intramolecular base-accelerated radical-scavenging reaction of a planar catechin derivative bearing a lysine moiety.
abstract: A planar catechin derivative incorporating a lysine moiety was synthesized and showed approximately 400-fold increased radical-scavenging activity relative to naturally-occurring (+)-catechin.
authors.affiliation: Division of Organic Chemistry, National Institute of Health Sciences, Setagaya-ku, Tokyo 158-8501, Japan. fukuhara@nihs.go.jp
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Fukuhara
authors.forename: Ikuo
authors.initials: I
authors.lastname: Nakanishi
authors.forename: Kei
authors.initials: K
authors.lastname: Ohkubo
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Obara
authors.forename: Ayako
authors.initials: A
authors.lastname: Tada
authors.forename: Kohei
authors.initials: K
authors.lastname: Imai
authors.forename: Akiko
authors.initials: A
authors.lastname: Ohno
authors.forename: Asao
authors.initials: A
authors.lastname: Nakamura
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Ozawa
authors.forename: Shiro
authors.initials: S
authors.lastname: Urano
authors.forename: Shinichi
authors.initials: S
authors.lastname: Saito
authors.forename: Shunichi
authors.initials: S
authors.lastname: Fukuzumi
authors.forename: Kazunori
authors.initials: K
authors.lastname: Anzai
authors.forename: Naoki
authors.initials: N
authors.lastname: Miyata
authors.forename: Haruhiro
authors.initials: H
authors.lastname: Okuda
mesh_terms: D002392:Catechin / Q000031:analogs & derivatives*; D016166:Free Radical Scavengers / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008239:Lysine / Q000737:chemistry*; D008958:Models, Molecular
chemical_list: D016166:Free Radical Scavengers; D002392:Catechin; D008239:Lysine