Role of extracellular adenosine in acute lung injury.
Acute lung injury (ALI) is a lung disease characterized by pulmonary edema and severe hypoxia. The past decade hosted a search for endogenous mechanisms controlling lung inflammation and pulmonary edema during ALI. As such, recent evidence indicates extracellular adenosine in orchestrating the resolution of pulmonary edema and inflammation during ALI.
Eckle
Tobias
T
Department of Anesthesiology, Mucosal Inflammation Program, University of Colorado Denver, Aurora, Colorado, USA.
Koeppen
Michael
M
Eltzschig
Holger K
HK
D000241:Adenosine / Q000502:physiology*; D000818:Animals; D002196:Capillaries / Q000502:physiology; D005110:Extracellular Space / Q000502:physiology*; D006801:Humans; D008171:Lung Diseases / Q000473:pathology*; D009711:Nucleotides / Q000378:metabolism; D011650:Pulmonary Alveoli / Q000502:physiology; D043705:Receptor, Adenosine A2A / Q000502:physiology; D043704:Receptor, Adenosine A2B / Q000502:physiology
D009711:Nucleotides; D043705:Receptor, Adenosine A2A; D043704:Receptor, Adenosine A2B; D000241:Adenosine