title: Id2-, RORgammat-, and LTbetaR-independent initiation of lymphoid organogenesis in ocular immunity.
abstract: The eye is protected by the ocular immunosurveillance system. We show that tear duct-associated lymphoid tissue (TALT) is located in the mouse lacrimal sac and shares immunological characteristics with mucosa-associated lymphoid tissues (MALTs), including the presence of M cells and immunocompetent cells for antigen uptake and subsequent generation of mucosal immune responses against ocularly encountered antigens and bacteria such as Pseudomonas aeruginosa. Initiation of TALT genesis began postnatally; it occurred even in germ-free conditions and was independent of signaling through organogenesis regulators, including inhibitor of DNA binding/differentiation 2, retinoic acid-related orphan receptor gammat, lymphotoxin (LT) alpha1beta2-LTbetaR, and lymphoid chemokines (CCL19, CCL21, and CXCL13). Thus, TALT shares immunological features with MALT but has a distinct tissue genesis mechanism and plays a key role in ocular immunity.
authors.affiliation: Division of Mucosal Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Nagatake
authors.forename: Satoshi
authors.initials: S
authors.lastname: Fukuyama
authors.forename: Dong-Young
authors.initials: DY
authors.lastname: Kim
authors.forename: Kaoru
authors.initials: K
authors.lastname: Goda
authors.forename: Osamu
authors.initials: O
authors.lastname: Igarashi
authors.forename: Shintaro
authors.initials: S
authors.lastname: Sato
authors.forename: Tomonori
authors.initials: T
authors.lastname: Nochi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sagara
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Yokota
authors.forename: Anton M
authors.initials: AM
authors.lastname: Jetten
authors.forename: Tsuneyasu
authors.initials: T
authors.lastname: Kaisho
authors.forename: Shizuo
authors.initials: S
authors.lastname: Akira
authors.forename: Hitomi
authors.initials: H
authors.lastname: Mimuro
authors.forename: Chihiro
authors.initials: C
authors.lastname: Sasakawa
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Fukui
authors.forename: Kohtaro
authors.initials: K
authors.lastname: Fujihashi
authors.forename: Taishin
authors.initials: T
authors.lastname: Akiyama
authors.forename: Jun-ichiro
authors.initials: J
authors.lastname: Inoue
authors.forename: Josef M
authors.initials: JM
authors.lastname: Penninger
authors.forename: Jun
authors.initials: J
authors.lastname: Kunisawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kiyono
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D004848:Epithelium / Q000276:immunology / Q000648:ultrastructure; D000939:Epitopes / Q000276:immunology; D007109:Immunity / Q000276:immunology*; D007114:Immunization; D007070:Immunoglobulin A / Q000276:immunology; D051797:Inhibitor of Differentiation Protein 2 / Q000378:metabolism; D007765:Lacrimal Apparatus / Q000196:embryology* / Q000276:immunology* / Q000382:microbiology / Q000648:ultrastructure; D008221:Lymphoid Tissue / Q000196:embryology* / Q000276:immunology* / Q000382:microbiology / Q000648:ultrastructure; D053361:Lymphotoxin alpha1, beta2 Heterotrimer / Q000378:metabolism; D051379:Mice; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3; D038081:Organogenesis / Q000276:immunology*; D018168:Receptors, Retinoic Acid / Q000378:metabolism; D011988:Receptors, Thyroid Hormone / Q000378:metabolism
chemical_list: D000939:Epitopes; C497452:Idb2 protein, mouse; D007070:Immunoglobulin A; D051797:Inhibitor of Differentiation Protein 2; D053361:Lymphotoxin alpha1, beta2 Heterotrimer; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3; D018168:Receptors, Retinoic Acid; D011988:Receptors, Thyroid Hormone; C539901:Rorc protein, mouse