[Common variable immunodeficiency. Prognostic factors for lung damage].
OBJECTIVE
Lung damage is considered to be key to Common Variable Immunodeficiency (CVID) prognosis. We describe lung damage in pediatric CVID patients and assess its relationship with memory B cells (MB) phenotype, immunoglobulin G (IgG) levels at the time of diagnosis, and diagnostic delay. We also assessed the prevalence of allergy and autoimmune phenomena.


METHODS
Cross-sectional study of 17 CVID patients treated at Vall d'Hebron University Hospital. Prevalence ratio and prevalence odds ratio were used to assess the effect of MB cells phenotype, IgG levels and diagnostic delay on lung damage.


RESULTS
Five of seventeen patients presented bronchiectasis. Diagnostic delay >5 years was significantly associated with more severe lung damage. MBO phenotype and low IgG levels at the time of diagnosis showed a trend to more severe lung damage without reaching statistical signification. A higher prevalence of allergic or autoimmune phenomena was not observed.


CONCLUSIONS
Latter diagnosis is associated with greater lung damage in CVID patients. The study of MB cells should be included in the study of these patients.
Sala Cunill
Anna
A
Sección de Alergia, Hospital Universitari Vall d'Hebron, Barcelona, España.
Soler-Palacín
Pere
P
Martín De Vicente
Carlos
C
Labrador Horrillo
Moisés
M
Luengo Sánchez
Olga
O
Figueras Nadal
Concepció
C
D000293:Adolescent; D002648:Child; D017074:Common Variable Immunodeficiency / Q000150:complications*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008171:Lung Diseases / Q000175:diagnosis / Q000276:immunology*; D008297:Male; D011379:Prognosis