Effects of drug solubility on the release kinetics of water soluble and insoluble drugs from HPMC based matrix formulations.
The purpose of the present research work was to observe the effects of drug solubility on their release kinetics of water soluble verpamil hydrochloride and insoluble aceclofenac from hydrophilic polymer based matrix formulations. Matrix formulations were prepared by the direct compression method. The formulations were evaluated for various physical parameters. Along with the dynamics of water uptake and erosion, SEM and in vitro drug release of the tablets were studied. Applying an exponential equation, it was found that the kinetics of soluble drug release followed anomalous non-Fickian diffusion transport whereas insoluble drug showed zero-order release. SEM study showed pore formation on the tablet surface that differed depending on drug solubility. t-Test pointed to a significant difference in amount of both drugs released due to the difference in solubility. Solubility of the drug effects kinetics and the mechanism of drug release.
Chakraborty
Santanu
S
P.G. Department of Pharmaceutics, College of Pharmaceutical Sciences, Berhampur-760002 Orissa, India. santanu_nil@rediffmail.com
Khandai
Madhusmruti
M
Sharma
Anuradha
A
Patra
Ch Niranjan
ChN
Patro
V Jagannath
VJ
Sen
Kalyan Kumar
KK
D002626:Chemistry, Pharmaceutical / Q000379:methods; D003692:Delayed-Action Preparations; D004008:Diclofenac / Q000031:analogs & derivatives / Q000737:chemistry / Q000493:pharmacokinetics; D065347:Hypromellose Derivatives; D008747:Methylcellulose / Q000031:analogs & derivatives* / Q000737:chemistry / Q000493:pharmacokinetics; D012995:Solubility; D013607:Tablets; D014700:Verapamil / Q000737:chemistry / Q000493:pharmacokinetics; D014867:Water / Q000737:chemistry / Q000378:metabolism*
D003692:Delayed-Action Preparations; D013607:Tablets; D014867:Water; D004008:Diclofenac; D065347:Hypromellose Derivatives; D008747:Methylcellulose; D014700:Verapamil; C056498:aceclofenac