Pregnancy in Marfan syndrome: maternal and fetal risk and recommendations for patient assessment and management.
Pregnancy in women with the Marfan syndrome (MFS) is associated with the potential for a catastrophic and even fatal acute aortic dissection and the risk of having a child who will inherit the syndrome. The approach to pregnancy in patients with MFS is therefore challenging and deserves special considerations. This article presents an extensive review of available clinical information and provides recommendations for the management of patients with MFS during pregnancy.
Goland
Sorel
S
Kaplan Medical Center, Rehovot, Israel.
Barakat
Mohamad
M
Khatri
Nudrat
N
Elkayam
Uri
U
D000328:Adult; D000784:Aortic Dissection / Q000209:etiology; D001014:Aortic Aneurysm / Q000209:etiology; D005260:Female; D005315:Fetal Diseases / Q000453:epidemiology / Q000235:genetics; D006801:Humans; D008382:Marfan Syndrome / Q000150:complications* / Q000453:epidemiology / Q000235:genetics*; D017063:Outcome Assessment, Health Care; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000209:etiology*; D012307:Risk Factors