title: Human acellular dermal matrix: an innovative tool for diaphragmatic reconstruction in patients with large intra-abdominal tumors.
abstract: BACKGROUND
  Patients presenting with large intra-abdominal tumors often require multivisceral organ resection including partial or complete hemidiaphragm excision to achieve complete gross and microscopic tumor resection.
  
  
  METHODS
  The ideal surgical approach to the repair of major diaphragmatic defects, particularly in a contaminated surgical field, is not well defined, but the use of prosthetic mesh in these situations is contraindicated.
  
  
  RESULTS
  We report our experience using human acellular dermal matrix for the repair of large diaphragmatic defects in these patients.
  
  
  CONCLUSIONS
  Human acellular dermal matrix is a safe and effective option in the surgical reconstruction of diaphragmatic defects in patients with large intra-abdominal tumors.
authors.affiliation: Section of Surgical Oncology, Department of Surgery, Penn State College of Medicine, PO Box 850, 500 University Dr., H070, Hershey, PA 17033, USA.
authors.forename: Diego
authors.initials: D
authors.lastname: Avella
authors.forename: Luis J
authors.initials: LJ
authors.lastname: Garcia
authors.forename: Niraj J
authors.initials: NJ
authors.lastname: Gusani
authors.forename: Mehrdad
authors.initials: M
authors.lastname: Nikfarjam
authors.forename: Serene
authors.initials: S
authors.lastname: Shereef
authors.forename: Eric T
authors.initials: ET
authors.lastname: Kimchi
authors.forename: Kevin F
authors.initials: KF
authors.lastname: Staveley-O'Carroll
mesh_terms: D000368:Aged; D003094:Collagen; D003964:Diaphragm / Q000601:surgery*; D004067:Digestive System Neoplasms / Q000473:pathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection; D006085:Graft Survival; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D019651:Plastic Surgery Procedures / Q000379:methods*; D012186:Retroperitoneal Neoplasms / Q000473:pathology / Q000601:surgery*; D018570:Risk Assessment; D012494:Sampling Studies; D013524:Surgical Flaps; D016896:Treatment Outcome; D014945:Wound Healing / Q000502:physiology
chemical_list: C440568:Alloderm; D003094:Collagen