title: Diastereoisomeric macrocyclic polydisulfides from the mangrove Bruguiera gymnorrhiza.
abstract: The uncommon macrocyclic polydisulfides, trans-3,3'-dihydroxy-1,5,1',5'-tetrathiacyclodecane (1), cis-3,3'-dihydroxy-1,5,1',5'-tetrathiacyclodecane (2), along with five known related cyclic disulfides, gymnorrhizol (3), neogymnorrhizol (4), bruguiesulfurol (5), brugierol (6), and isobrugierol (7), were isolated from the mangrove Bruguiera gymnorrhiza collected from Guangdong Province, China. Structures of compounds 1 and 2 were determined by extensive analysis of their spectroscopic data, by comparison of their NMR spectroscopic data with those of the co-occurring known compounds, as well as by single-crystal X-ray diffraction analysis. A possible biogenetic origin was also proposed.
authors.affiliation: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zu Chong Zhi Rd. 555, Zhangjiang Hi-Tech Park, Shanghai 201203, PR China.
authors.forename: Xiao-Ying
authors.initials: XY
authors.lastname: Huang
authors.forename: Qi
authors.initials: Q
authors.lastname: Wang
authors.forename: Hai-Li
authors.initials: HL
authors.lastname: Liu
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Guo-Rong
authors.initials: GR
authors.lastname: Xin
authors.forename: Xu
authors.initials: X
authors.lastname: Shen
authors.forename: Mei-Ling
authors.initials: ML
authors.lastname: Dong
authors.forename: Yue-Wei
authors.initials: YW
authors.lastname: Guo
mesh_terms: D004220:Disulfides / Q000737:chemistry / Q000302:isolation & purification*; D047028:Macrocyclic Compounds / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D018515:Plant Leaves; D018547:Plant Stems; D043982:Rhizophoraceae / Q000737:chemistry*; D013237:Stereoisomerism; D014961:X-Ray Diffraction
chemical_list: D004220:Disulfides; D047028:Macrocyclic Compounds; C548532:trans-3,3'-dihydroxy-1,5,1',5'-tetrathiacyclodecane