title: Chronic constipation: overview and challenges.
abstract: Despite its high prevalence and cost implications, our understanding of the pathophysiology of constipation remains primitive, and available therapies have limited efficacy. The purpose of this supplement is to address critically the reasons for the current lack of understanding and to propose avenues of future research to address these deficiencies.
authors.affiliation: University of New South Wales, Department of Gastroenterology, St George Hospital, Sydney, NSW, Australia. i.cook@unsw.edu.au
authors.forename: I J
authors.initials: IJ
authors.lastname: Cook
authors.forename: N J
authors.initials: NJ
authors.lastname: Talley
authors.forename: M A
authors.initials: MA
authors.lastname: Benninga
authors.forename: S S
authors.initials: SS
authors.lastname: Rao
authors.forename: S M
authors.initials: SM
authors.lastname: Scott
mesh_terms: D002908:Chronic Disease; D003248:Constipation / Q000145:classification / Q000175:diagnosis / Q000191:economics / Q000453:epidemiology / Q000628:therapy*; D005772:Gastrointestinal Transit / Q000502:physiology; D006801:Humans; D008365:Manometry; D011237:Predictive Value of Tests; D011379:Prognosis; D012007:Rectum / Q000503:physiopathology; D016896:Treatment Outcome