Role of NF-kappa B in the pathogenesis of diabetes and its associated complications.
The nuclear factor-kappaB (NF-kappaB) family is comprised of DNA-binding protein factors that are required for the transcription of most proinflammatory molecules, including adhesion molecules, enzymes, cytokines, and chemokines. Studies performed in a variety of cell and animal based experimental systems suggest that NF-kappaB activation is a key event early in the pathobiology of diabetes. The purpose of this review is to summarize the current knowledge about the molecular biology of NF-kappaB and to review evidence that implicates NF-kappaB in the pathogenesis of diabetes and its associated complications.
Patel
Sandip
S
Department of Pharmacology, Indukaka Ipcowala College of Pharmacy, New Vallabh Vidyanagar, Anand, Gujarat 388121, India. patelsandozrx@gmail.com
Santani
Dev
D
D000818:Animals; D048909:Diabetes Complications / Q000209:etiology* / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D003920:Diabetes Mellitus / Q000209:etiology* / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D016328:NF-kappa B / Q000235:genetics / Q000502:physiology*
D016328:NF-kappa B