[Mutator hypothesis of carcinogenesis and supermutagens in anticancer therapy].
The putative causative relationship between mutator nature of carcinogenesis and positive results of empirical application of supermutagens for anticancer therapy is discussed. Part 1 of the review is devoted to the substantiation of the mutator theory of carcinogenesis. Part 2 provides an explanation of positive results of empirical application of supermutagens for anticancer therapy in the framework of this theory.
Krutiakov
V M
VM
D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects*; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D006801:Humans; D008962:Models, Theoretical; D009153:Mutagens / Q000009:adverse effects*; D009154:Mutation; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology
D000970:Antineoplastic Agents; D009153:Mutagens