title: Effects of different priming doses of propofol on fentanyl-induced cough during anesthesia induction: a preliminary randomized controlled study.
abstract: Fentanyl-induced cough is not an uncommon condition during the induction of general anesthesia. A preliminary randomized controlled study was designed to observe the effects of different priming doses of propofol on fentanyl-induced cough during anesthesia induction. A total of 120 patients were randomized into 4 groups (n = 30) to receive the intravenous injection of intralipid (group I), propofol 1 mg.kg(-1) (group II), propofol 1.5 mg.kg(-1) (group III), or propofol 2 mg.kg(-1) (group IV) 1 minute before a bolus of fentanyl 2.5 microg.kg(-1). The occurrence and severity of cough were recorded for 2 minutes after fentanyl bolus. The severity of cough was graded as none (grade 0), mild (grade 1-2), moderate (grade 3-4), or severe (grade 5 or more). The average bolus time of fentanyl was 1.5 +/- 0.3 seconds in the present study. The incidence of fentanyl-induced cough was 80.0% in group I, 40.0% in group II, 6.7% in group III, and 3.3% in group IV, respectively. Groups II, III, and IV had a lower incidence and less severity of cough than group I (P < 0.05). Groups III and IV had a lower incidence and less severity of cough than group II (P < 0.05). In summary, a priming dose of more than 1 mg.kg(-1) of propofol is effective to suppress fentanyl-induced cough in a dose-dependent manner. We suggest using a priming dose of propofol 1.5 mg.kg(-1) to suppress cough during the anesthesia induction with propofol and fentanyl in clinical practice.
authors.affiliation: Department of Anesthesiology, Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, P. R. China.
authors.forename: Qifeng
authors.initials: Q
authors.lastname: Tang
authors.forename: Yanning
authors.initials: Y
authors.lastname: Qian
authors.forename: Qingwei
authors.initials: Q
authors.lastname: Zhang
authors.forename: Jianjun
authors.initials: J
authors.lastname: Yang
authors.forename: Zhongyun
authors.initials: Z
authors.lastname: Wang
mesh_terms: D000759:Adjuvants, Anesthesia / Q000009:adverse effects*; D000328:Adult; D018686:Anesthetics, Intravenous / Q000008:administration & dosage*; D003371:Cough / Q000139:chemically induced*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005283:Fentanyl / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015742:Propofol / Q000008:administration & dosage*
chemical_list: D000759:Adjuvants, Anesthesia; D018686:Anesthetics, Intravenous; D005283:Fentanyl; D015742:Propofol