title: In vivo siRNA delivery with dendritic poly(L-lysine) for the treatment of hypercholesterolemia.
abstract: Intravenous delivery of apolipoprotein B-specific siRNA with a sixth-generation of dendritic poly(L-lysine) (KG6) resulted in siRNA-mediated knockdown of ApoB in healthy C57BL/6 mice without hepatotoxicity, and with a significant reduction of serum low-density lipoprotein cholesterol in apolipoprotein E-deficient mice.
authors.affiliation: Department of Applied Chemistry, Faculty of Engineering, Kyushu University, Fukuoka 819-0395, Japan.
authors.forename: Kazuto
authors.initials: K
authors.lastname: Watanabe
authors.forename: Mariko
authors.initials: M
authors.lastname: Harada-Shiba
authors.forename: Akira
authors.initials: A
authors.lastname: Suzuki
authors.forename: Risa
authors.initials: R
authors.lastname: Gokuden
authors.forename: Ryohsuke
authors.initials: R
authors.lastname: Kurihara
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Sugao
authors.forename: Takeshi
authors.initials: T
authors.lastname: Mori
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Katayama
authors.forename: Takuro
authors.initials: T
authors.lastname: Niidome
mesh_terms: D000818:Animals; D001055:Apolipoproteins B / Q000235:genetics / Q000502:physiology; D050091:Dendrimers / Q000138:chemical synthesis / Q000737:chemistry*; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry*; D006937:Hypercholesterolemia / Q000188:drug therapy*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D011107:Polylysine / Q000138:chemical synthesis / Q000737:chemistry*; D034741:RNA, Small Interfering / Q000008:administration & dosage* / Q000737:chemistry / Q000502:physiology*; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D001055:Apolipoproteins B; D050091:Dendrimers; D004337:Drug Carriers; D034741:RNA, Small Interfering; D011107:Polylysine