Effect of caricapryl-99 seed alkaloid extract on the serum levels of sex hormones and pituitary gonadotrophins in male albino rats.
Activity of alkaloid extract of caricapryl-99 seeds [Carica papaya Linn seeds] on the serum levels of steroid hormones was studied in adult male albino rats. Three tolerated doses obtained from the graph of percentage toxicity [10, 50 and 150 mg/kg] were separately administered orally, daily for three days to three groups of male rats [n=5] while group four of 5 rats received the vehicle [corn oil] as control. The results showed that 10 mg/kg/d caused increase serum levels of FSH and estrogen but decrease in the serum levels of LH and testosterone compared to control; 50 mg/kg/d elevated the serum levels of FSH, estrogen but inhibited testosterone; while 150 mg/kg/d pretreatments caused a significant decrease [p<0.01] in the serum levels of FSH, LH and testosterone. The results suggest that caricapryl-99 treatment inhibited the serum level of the androgen, testosterone which might result in a male infertility.
Udoh
P B
PB
Department of Zoology and Environmental Biology, University of Calabar, Calabar, Nigeria. pbudoh@yahoo.com
Udoh
F V
FV
Umoren
E B
EB
James
U W
UW
Okeke
C P
CP
Agwu
B
B
D000284:Administration, Oral; D000470:Alkaloids / Q000008:administration & dosage / Q000633:toxicity*; D000818:Animals; D029441:Carica; D004305:Dose-Response Relationship, Drug; D004967:Estrogens / Q000097:blood; D005640:Follicle Stimulating Hormone / Q000097:blood; D012739:Gonadal Steroid Hormones / Q000097:blood*; D006065:Gonadotropins, Pituitary / Q000097:blood*; D007248:Infertility, Male / Q000097:blood / Q000139:chemically induced; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D012639:Seeds; D013739:Testosterone / Q000097:blood
D000470:Alkaloids; D004967:Estrogens; D012739:Gonadal Steroid Hormones; D006065:Gonadotropins, Pituitary; D010936:Plant Extracts; D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone