title: First report of a medullar cord compression secondary to osseous plasmacytoma successfully treated with bortezomib and dexamethasone.
abstract: Medullar cord compression secondary to osseous plasmacytomas affecting the vertebrae is an oncological emergency. A 75-year-old woman with recurrent osseous plasmacytomas and thoracic spinal cord compression, previously treated with radiotherapy, was successfully treated with bortezomib and dexamethasone. Three years later, when the plasmacytoma and spinal cord compression relapsed, she was retreated with the same therapeutic scheme, achieving a new complete clinical remission. This is the first reported case of an excellent response to the combination of bortezomib and dexamethasone for spinal cord compression due to osseous plasmacytoma.
authors.forename: I
authors.initials: I
authors.lastname: Español
authors.forename: A
authors.initials: A
authors.lastname: Martínez
authors.forename: M D
authors.initials: MD
authors.lastname: López
authors.forename: T
authors.initials: T
authors.lastname: Iturbe
authors.forename: A
authors.initials: A
authors.lastname: Tejedor
authors.forename: M C
authors.initials: MC
authors.lastname: García
authors.forename: S
authors.initials: S
authors.lastname: Cavero
authors.forename: C
authors.initials: C
authors.lastname: Funes
authors.forename: J
authors.initials: J
authors.lastname: Ibáñez
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D001897:Boronic Acids / Q000008:administration & dosage; D000069286:Bortezomib; D003907:Dexamethasone / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008875:Middle Aged; D010954:Plasmacytoma / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D011719:Pyrazines / Q000008:administration & dosage; D013117:Spinal Cord Compression / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D016896:Treatment Outcome
chemical_list: D001897:Boronic Acids; D011719:Pyrazines; D000069286:Bortezomib; D003907:Dexamethasone