Leptin's RIGHT turn to the brain stem.
In a paper by Yadav and colleagues, a novel pathway linking the central nervous system effects of leptin on bone mass and energy expenditure to serotonin signaling in brainstem circuits is described. The data from those studies strengthen the tenet that skeletal remodeling is intimately connected to central regulation of metabolism.
Rosen
Clifford J
CJ
Maine Medical Center Research Institute, Scarborough, ME 04074, USA. rosenc@mmc.org
D000818:Animals; D015519:Bone Density / Q000502:physiology*; D001842:Bone and Bones / Q000378:metabolism; D001933:Brain Stem / Q000166:cytology / Q000378:metabolism*; D004734:Energy Metabolism / Q000502:physiology*; D006801:Humans; D020738:Leptin / Q000378:metabolism*; D051379:Mice; D009415:Nerve Net; D012701:Serotonin / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology
D020738:Leptin; D012701:Serotonin