Myocardial infarction in a young patient with a previous history of repeated thrombophlebitis: combination of factor V Leiden and prothrombin G20210A gene polymorphisms with coronary artery disease.
We report a case of myocardial infarction at a young age in a person with a medical history of repeated thrombophlebitis, who was heterozygous for the prothrombin G20210A mutation and homozygous for factor V Leiden mutation. A coronary angiography revealed the presence of a moderate atherosclerotic plaque (60%) in the left anterior descending coronary artery, which gave rise to suspicion of a relationship between prothrombotic gene mutations and atherosclerosis. Genetic screening for inherited thrombophilia, especially in the presence of a strong familiarity or previous venous thrombosis, and the evaluation of atherosclerotic risk factors, may be critical information for primary prevention of arterial thrombosis.
Mugnolo
Antonio
A
Division of Cardiology, Department of Biomedical and Surgical Sciences, University of Verona, Verona, Italy.
Toniolo
Mauro
M
Cicoira
Mariantonietta
M
Vassanelli
Francesca
F
Vassanelli
Corrado
C
D003324:Coronary Artery Disease / Q000150:complications*; D005165:Factor V / Q000235:genetics*; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000235:genetics*; D011516:Prothrombin / Q000235:genetics*; D013924:Thrombophlebitis / Q000150:complications*; D055815:Young Adult
C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin