title: [Evaluation of soft tissue reactions to three nonabsorbable suture materials in a rabbit model].
abstract: OBJECTIVE
  We evaluated the inflammatory reactions induced by three commonly used nonabsorbable suture materials in a rabbit model.
  
  
  METHODS
  Three suture materials were tested: braided polyester suture (Ethibond), braided blend of polyester and polyethylene suture (FiberWire), and monofilament polypropylene suture (Polypropylene). Thirty-six rabbits were randomly allocated to three suture groups, equal in number. Each suture type was placed bilaterally in the quadriceps muscle, patellar tendon, knee joint capsule, and Achilles tendon. Six animals in each group were sacrificed in the third and sixth weeks. The inflammation induced by each suture was assessed using light microscopy and the width of the inflammation zone (WIZ) was measured.
  
  
  RESULTS
  Ethibond was found to cause the most severe reaction in the muscle and tendon in the third week; in the sixth week, however, it showed the lowest inflammatory reaction in all tissue types. Reaction to Propylene was moderate in the third week, whereas it caused the largest WIZ in all tissue types in the sixth week, such that the eventual size of the WIZ induced by Propylene (6.6 + or - 2.1 mm) was significantly greater than that of Ethibond (1.6 + or - 0.9 mm) in muscle specimens (p<0.05). Except for the largest WIZ seen in joint capsule specimens in the third week, inflammatory reactions associated with FiberWire were low or moderate in all tissue specimens throughout the study. FiberWire was associated with some necrotic areas in two muscle and one tendon specimens.
  
  
  CONCLUSIONS
  The extent of inflammatory reaction to nonabsorbable suture materials depends on the type of suture material, tissue type, and the duration of postoperative time.
authors.affiliation: Department of Orthopedics and Traumatology, Vakif Gureba Training and Research Hospital, Istanbul, Turkey. esenyel@yahoo.com
authors.forename: Cem Zeki
authors.initials: CZ
authors.lastname: Esenyel
authors.forename: Mehmet
authors.initials: M
authors.lastname: Demirhan
authors.forename: Onder
authors.initials: O
authors.lastname: Kiliçoğlu
authors.forename: Oktay
authors.initials: O
authors.lastname: Adanir
authors.forename: Bilge
authors.initials: B
authors.lastname: Bilgiç
authors.forename: Ozlem
authors.initials: O
authors.lastname: Güzel
authors.forename: Serhat
authors.initials: S
authors.lastname: Ozsoy
mesh_terms: D000818:Animals; D023421:Models, Animal; D011817:Rabbits; D017695:Soft Tissue Injuries / Q000209:etiology*; D013537:Sutures / Q000009:adverse effects*