Evaluation of the material and tablet formation properties of modified forms of Dioscorea starches.
Starches obtained from four different Dioscorea species-namely, White yam (Dioscorea rotundata), Bitter yam (Dioscorea dumetorum), Chinese yam (Dioscorea oppositifolia), and Water yam (Dioscorea alata)-were modified by cross-linking, hydroxypropylation, and dual modification-cross-linking followed by hydroxypropylation. The physicochemical, material, and tablet properties of the modified starches were investigated with the aim of understanding their properties to determine their potential use for different applications. The tablet formation properties were assessed using 3D modeling, the Heckel equation, and force-displacement profiles. The analyzed tablet properties were elastic recovery, compactibility, and disintegration. The result indicates that the modifications generally increased the swelling power for all the starches in the rank order hydroxypropyl > hydroxypropylated cross-linked > cross-linked (CL) while the solubility did not show a clear-cut pattern. This indicates that hydroxypropylation generally showed the strongest effects on swelling. Furthermore, hydroxypropylation improved the hot water swelling of the CL starches. The modifications did not cause any detectable morphological change in the starch granules shape or size although slight rupture was observed in some granules. CL starch had the lowest water sorption capacity and hydroxypropylation increased the sorption capacity of the CL starches. The material property results indicate that hydroxypropylation and cross-linking did not significantly improve the flowability and compressibility but improved bonding, which resulted in an increased compaction and higher tablet crushing force even though they all disintegrated rapidly. Thus, the modified Dioscorea starches showed potentials for development as new excipients in solid dosage form design, and they could be useful as disintegrants or for Soft tableting.
Odeku
Oluwatoyin A
OA
Department of Pharmaceutics and Biopharmaceutics, Institute of Pharmacy, Martin-Luther-University Halle-Wittenberg, Halle/Saale, Germany.
Picker-Freyer
Katharina M
KM
D002152:Calorimetry, Differential Scanning; D003432:Cross-Linking Reagents / Q000737:chemistry*; D027742:Dioscorea / Q000737:chemistry*; D004339:Drug Compounding / Q000379:methods*; D004548:Elasticity; D004852:Epoxy Compounds / Q000737:chemistry; D005079:Excipients / Q000737:chemistry* / Q000302:isolation & purification; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D008956:Models, Chemical; D010316:Particle Size; D033362:Powder Diffraction; D012995:Solubility; D013059:Spectrum Analysis, Raman; D013213:Starch / Q000737:chemistry* / Q000302:isolation & purification; D013499:Surface Properties; D013607:Tablets / Q000737:chemistry*; D014867:Water / Q000032:analysis
D003432:Cross-Linking Reagents; D004852:Epoxy Compounds; D005079:Excipients; D013607:Tablets; D014867:Water; D013213:Starch; C009068:propylene oxide