title: Transrectal ultrasound-guided prostatic biopsy: midazolam, the ideal analgesic.
abstract: OBJECTIVE
  Patients with raised serum prostate-specific antigen and/or an abnormal-feeling prostate were subjected to transrectal ultrasound-guided prostatic biopsy to rule out any prostatic malignancy. There are many methods for pain relief and to treat discomfort during the procedure but we compared the efficacy of intravenous (IV) midazolam for pain control.
  
  
  METHODS
  This was a prospective study of 50 patients. All patients underwent a ten quadrant biopsy. The patients were divided into two groups: group 1 (study group) which included 25 patients who used 1 ml of IV midazolam and group 2 (control group) which included 25 patients who did not use IV midazolam.
  
  
  RESULTS
  In group 1, of 25 patients only 1 patient had mild pain (VAS 2) during and after the procedure. In group 2, of 25 patients, 15 patients had pain during the procedure.
  
  
  CONCLUSIONS
  Midazolam is a benzodiazepine derivative with an anxiolytic, sedative, amnestic and hypnotic action. Our study shows that using midazolam is a very simple technique which gives excellent analgesia and no other analgesia was required. No monitoring was needed, there was a very low incidence of complications and it did not require any technical expertise.
authors.affiliation: P.D. Hinduja National Hospital, Mumbai, India. prits_2121@yahoo.co.in
authors.forename: Pritesh
authors.initials: P
authors.lastname: Shrimali
authors.forename: Yogesh
authors.initials: Y
authors.lastname: Bhandari
authors.forename: Sushil
authors.initials: S
authors.lastname: Kharbanda
authors.forename: Mangesh
authors.initials: M
authors.lastname: Patil
authors.forename: Vardachary
authors.initials: V
authors.lastname: Srinivas
authors.forename: Satish
authors.initials: S
authors.lastname: Gaitonde
authors.forename: Ranjit
authors.initials: R
authors.lastname: Mankeshwar
mesh_terms: D000698:Analgesia; D018686:Anesthetics, Intravenous / Q000627:therapeutic use*; D001706:Biopsy / Q000009:adverse effects / Q000379:methods; D006801:Humans; D008297:Male; D008874:Midazolam / Q000627:therapeutic use*; D010146:Pain / Q000209:etiology / Q000517:prevention & control*; D011446:Prospective Studies; D011467:Prostate / Q000000981:diagnostic imaging* / Q000473:pathology*; D014463:Ultrasonography
chemical_list: D018686:Anesthetics, Intravenous; D008874:Midazolam