Myasthenia gravis and autoimmune Addison disease in a patient with thymoma.
The association of thymoma with myasthenia gravis has been well documented. However, the relationship between these two syndromes and Addison disease are very rarely encountered in clinical practice. We report on a 32-year-old man who underwent a resection for thymoma 48 months ago. The diagnosis of Addison disease was made followed by a diagnosis of myasthenia gravis on the basis of a high titer of acetylcholine receptor levels. The treatment of oral prednisolone 7.5 mg/day and oral prostigmine 180 mg/day was initiated. His symptoms and physical signs were improved after this treatment. To our knowledge, this is the fourth reported case of thymoma synchronously associated with myasthenia gravis and Addison disease.
Seker
Mesut
M
Department of Medical Oncology, Dr. Lutfi Kirdar Kartal Education and Research Hospital, Istanbul, Turkey. mnseker@hotmail.com
Gozu
Hulya Iliksu
HI
Oven Ustaalioğlu
Bala Basak
BB
Sonmez
Berkant
B
Erkal
Fatih Yavuz
FY
Kocak
Mihriban
M
Barisik
Nagehan Ozdemir
NO
Orbay
Ekrem
E
Sargin
Mehmet
M
Sargin
Haluk
H
Boru
Ulku Turk
UT
Yaylaci
Mustafa
M
D000109:Acetylcholine / Q000378:metabolism*; D000224:Addison Disease / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D000284:Administration, Oral; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage; D002800:Cholinesterase Inhibitors / Q000008:administration & dosage; D006801:Humans; D008297:Male; D009157:Myasthenia Gravis / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D009388:Neostigmine / Q000008:administration & dosage; D011239:Prednisolone / Q000008:administration & dosage; D011950:Receptors, Cholinergic / Q000096:biosynthesis / Q000097:blood / Q000235:genetics; D013945:Thymoma / Q000150:complications* / Q000276:immunology / Q000503:physiopathology / Q000601:surgery*; D013953:Thymus Neoplasms / Q000150:complications* / Q000276:immunology / Q000601:surgery*
D000893:Anti-Inflammatory Agents; D018931:Antineoplastic Agents, Hormonal; D002800:Cholinesterase Inhibitors; D011950:Receptors, Cholinergic; D009388:Neostigmine; D011239:Prednisolone; D000109:Acetylcholine