title: Inhibitive effects of alkyl gallates on hyaluronidase and collagenase.
abstract: A series of the gallate esters of n-alkanols (C(1)-C(12)) was examined to determine their inhibitory activities against hyaluronidase and collagenase. Hexyl, heptyl, octyl, nonyl, and decyl gallates inhibited both hyaluronidase and collagenase, and the most potent inhibitor was octyl gallate against both enzymes. Octyl 3,5-dihydroxybenzoate showed inhibitory effects on hyaluronidase, whereas collagenase was inhibited by octyl 3,4-dihydroxybenzoate.
authors.affiliation: Department of Applied Biological Chemistry, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Sakai, Osaka, Japan.
authors.forename: Florin
authors.initials: F
authors.lastname: Barla
authors.forename: Hayato
authors.initials: H
authors.lastname: Higashijima
authors.forename: Shingo
authors.initials: S
authors.lastname: Funai
authors.forename: Keiichiro
authors.initials: K
authors.lastname: Sugimoto
authors.forename: Naoki
authors.initials: N
authors.lastname: Harada
authors.forename: Ryoichi
authors.initials: R
authors.lastname: Yamaji
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Fujita
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Nakano
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Inui
mesh_terms: D000818:Animals; D002417:Cattle; D047009:Hathewaya histolytica / Q000201:enzymology; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D005707:Gallic Acid / Q000737:chemistry* / Q000494:pharmacology*; D006821:Hyaluronoglucosaminidase / Q000037:antagonists & inhibitors*; D020128:Inhibitory Concentration 50; D061965:Matrix Metalloproteinase Inhibitors
chemical_list: D004791:Enzyme Inhibitors; D061965:Matrix Metalloproteinase Inhibitors; D005707:Gallic Acid; D006821:Hyaluronoglucosaminidase