title: Hypotensive effect of Chamaemelum nobile aqueous extract in spontaneously hypertensive rats.
abstract: This study aims to evaluate the hypotensive effect of Chamaemelum nobile aqueous extract (CNAE) in spontaneously hypertensive rats (SHRs). Single oral administration of CNAE (140 mg/kg) produced a significant reduction (p < 0.05) in systolic blood pressure (SBP) after 24 h of the administration. Daily oral administration of CNAE (140 mg/kg) during 3 weeks produced a significant reduction in SBP in the day 8 (p < 0.01) of treatment. Furthermore, CNAE produced a significant increase in urinary output and electrolytes excretion (p < 0.01) from the day 8 to the end of treatment. We conclude that CNAE possesses a hypotensive and diuretic effect in SHR.
authors.affiliation: UFRPNPE B. P., Errachidia, Morocco.
authors.forename: Naoufel Ali
authors.initials: NA
authors.lastname: Zeggwagh
authors.forename: Abderahman
authors.initials: A
authors.lastname: Moufid
authors.forename: Jean Baptiste
authors.initials: JB
authors.lastname: Michel
authors.forename: Mohamed
authors.initials: M
authors.lastname: Eddouks
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D031167:Chamaemelum; D004195:Disease Models, Animal; D004232:Diuretics / Q000494:pharmacology / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004573:Electrolytes / Q000652:urine; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000097:blood; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D011918:Rats, Inbred SHR
chemical_list: D000959:Antihypertensive Agents; D004232:Diuretics; D004573:Electrolytes; D010936:Plant Extracts; D007703:Peptidyl-Dipeptidase A