title: Implantation of an atelocollagen sheet for the treatment of vocal fold scarring and sulcus vocalis.
abstract: OBJECTIVE
  The management of vocal fold scarring and sulcus vocalis is challenging. These disorders are thought to be fibroplastic anomalies in the cover portion of the vocal fold that cause deterioration of the vibratory properties of the vocal fold mucosa. Histologic studies have revealed disorganization of extracellular matrix that needs to be addressed in the treatment of scarred vocal folds. Replacement of scar tissues with an appropriate implant may lead to regeneration of the vocal fold mucosa and its tissue properties. This retrospective case study examined the feasibility of using an atelocollagen sheet as a regenerative implant.
  
  
  METHODS
  Six patients with a post-cordectomy scar or sulcus vocalis underwent implantation of an atelocollagen sheet into the lamina propria of the vocal folds. The procedure consisted of elevation of a microflap, dissection and removal of scar tissue, implantation of the material, and wound closure. Vocal function was evaluated before and after surgery by stroboscopic examination and by aerodynamic and acoustic analyses.
  
  
  RESULTS
  The postoperative changes of aerodynamic and acoustic parameters varied among patients; however, gradual improvement was seen in most cases over a year. Stroboscopic findings also revealed gradual improvement of vibratory properties in most cases.
  
  
  CONCLUSIONS
  Implantation of an atelocollagen sheet may have restorative effects on vocal fold scarring and sulcus vocalis in terms of tissue properties and function of the mucosa.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto, Japan.
authors.forename: Yo
authors.initials: Y
authors.lastname: Kishimoto
authors.forename: Shigeru
authors.initials: S
authors.lastname: Hirano
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Kojima
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Kanemaru
authors.forename: Juichi
authors.initials: J
authors.lastname: Ito
mesh_terms: D000162:Acoustics; D000328:Adult; D000368:Aged; D002921:Cicatrix / Q000473:pathology / Q000601:surgery; D003094:Collagen; D005260:Female; D006801:Humans; D007820:Laryngeal Mucosa / Q000473:pathology; D008297:Male; D008875:Middle Aged; D019919:Prosthesis Implantation / Q000379:methods; D012189:Retrospective Studies; D049489:Stroboscopy; D014827:Vocal Cords / Q000473:pathology / Q000601:surgery*; D014832:Voice Disorders / Q000601:surgery*
chemical_list: C059821:atelocollagen; D003094:Collagen