title: Successful two-stage correction of ventricular septal defect and patent ductus arteriosus in a patient with fixed pulmonary hypertension.
abstract: We report a case of a 6-year-old boy with fixed severe pulmonary artery hypertension secondary to a ventricular septal defect (VSD) together with a patent ductus arteriosus (PDA). As a preliminary step, PDA embolization was performed following therapy with inhaled prostacyclin over a period of 6 months. Further, the patient underwent successful surgical VSD closure. We postulate that a staged procedure with long-term prostaglandin therapy might be capable of reducing pulmonary artery resistance and permitting total correction in a patient once considered to have inoperable pulmonary arteriopathy.
authors.affiliation: Department of Pediatric Cardiology, Turkiye Yuksek Ihtisas Education and Research Hospital, Kizilay S, No: 4, 06100 Sihhiye, Ankara, Turkey. aysepac@gmail.com
authors.forename: Aysenur
authors.initials: A
authors.lastname: Pac
authors.forename: Tugcin Bora
authors.initials: TB
authors.lastname: Polat
authors.forename: Kerem
authors.initials: K
authors.lastname: Vural
authors.forename: Mustafa
authors.initials: M
authors.lastname: Pac
mesh_terms: D000280:Administration, Inhalation; D002648:Child; D003131:Combined Modality Therapy; D004374:Ductus Arteriosus, Patent / Q000628:therapy*; D004621:Embolization, Therapeutic; D006345:Heart Septal Defects, Ventricular / Q000601:surgery*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000628:therapy*; D016285:Iloprost / Q000008:administration & dosage*; D008297:Male; D055989:Septal Occluder Device; D014665:Vasodilator Agents / Q000008:administration & dosage*
chemical_list: D014665:Vasodilator Agents; D016285:Iloprost