[Application of fluorescence in situ hybridization in prenatal diagnosis of complex chromosomal abnormalities].
OBJECTIVE
To investigate the application of fluorescence in situ hybridization (FISH) technique in prenatal diagnosis of complex chromosomal abnormalities.


METHODS
Eleven prenatal diagnosis cases (8 from amniocentesis and 3 from cord blood) with complex chromosomal abnormalities detected by routine G-banding, were further analyzed by FISH.


RESULTS
The FISH technique confirmed the results of balanced chromosome rearrangements detected by G-banding, and clarified the structure of the derivative chromosomes in the 3 amniocentesis samples and the origin of the mark chromosomes in the 2 cord blood samples.


CONCLUSIONS
FISH can be used to diagnose the complex chromosomal abnormalities accurately in prenatal diagnosis, and can provide very useful genetic information for clinical diagnosis and treatment.
Shen
Yan-yan
YY
Xiamen Maternity and Child Health Care Hospital, Xiamen, Fujian, 361003, PR China.
Li
Jian
J
Kong
Hui
H
Wu
Hui-nan
HN
Wu
Qiong
Q
Ge
Yun-sheng
YS
Huang
Xin-li
XL
Zhou
Yu-lin
YL
D000653:Amniotic Fluid / Q000737:chemistry; D002869:Chromosome Aberrations; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D006801:Humans; D017404:In Situ Hybridization, Fluorescence / Q000379:methods*; D011247:Pregnancy / Q000235:genetics*; D011296:Prenatal Diagnosis / Q000379:methods*