title: Myeloperoxidase is not useful for the early assessment of patients with chest pain.
abstract: BACKGROUND
  Myeloperoxidase (MPO) has been listed as a potentially useful risk marker in acute coronary syndrome. However, its clinical utility in patients with acute chest pain is not yet defined.
  
  
  METHODS
  MPO (Architect, Abbott Diagnostics) was measured in 120 healthy controls and 303 chest pain patients who had been admitted to the coronary care units of three Swedish hospitals.
  
  
  RESULTS
  Chest pain patents had significantly higher median MPO levels compared to healthy controls (120.6 vs. 78. 9 pmol/L; p<0.001). However, MPO was not useful for the diagnosis of myocardial infarction (c-statistics 0.61 [95% CI 0.54-0.67]), and Cox regression analysis revealed no independent association between MPO and mortality (adjusted hazard ratio 1.3 [95% CI 0.8-2.0]) or the composite endpoint (adjusted hazard ratio 1.1 [95% CI 0.8-1.5]) after a median follow-up of 4.9 years.
  
  
  CONCLUSIONS
  MPO provided no clinically relevant information in the present population of chest pain patients.
authors.affiliation: Department of Medical Sciences, Cardiology, Uppsala University Hospital and Uppsala Clinical Research Center, Uppsala, Sweden. kai.eggers@ucr.uu.se
authors.forename: Kai M
authors.initials: KM
authors.lastname: Eggers
authors.forename: Mikael
authors.initials: M
authors.lastname: Dellborg
authors.forename: Nina
authors.initials: N
authors.lastname: Johnston
authors.forename: Jonas
authors.initials: J
authors.lastname: Oldgren
authors.forename: Eva
authors.initials: E
authors.lastname: Swahn
authors.forename: Per
authors.initials: P
authors.lastname: Venge
authors.forename: Bertil
authors.initials: B
authors.lastname: Lindahl
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood / Q000175:diagnosis; D000368:Aged; D015415:Biomarkers / Q000097:blood*; D002637:Chest Pain / Q000097:blood / Q000175:diagnosis; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000175:diagnosis; D009195:Peroxidase / Q000097:blood; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D009195:Peroxidase