title: Treatment of septicaemia and severe bacterial infections in foals with a new cefquinome formulation: a field study.
abstract: A multicentre field study was conducted in accordance with VICH Guideline on Good Clinical Practice (VICH 2000) to confirm the efficacy and safety of a new formulation of cefquinome for the treatment of naturally occurring severe bacterial infections and septicaemia in foals. Thirty-nine foals suffering from severe bacterial infections (such as pneumonia, gastro-enteritis, arthritis, omphalitis, or wound infections) or acute septicaemia were treated twice daily with the test product (1 mg cefquinome/kg body weight) intravenously for three days and then intramuscularly for three to 11 days. Investigators examined the foals daily and scored both systemic and local clinical signs to assess the response to treatment, treatment success and relapses. On the day of inclusion a blood sample was taken from each foal for IgG determination and blood culture. In case of abnormal clinical findings additional samples were taken for bacteriology. Treatment was successful in 87.2% of cases (34 of 39 foals) and no relapses were observed. The average duration of treatment was 7.5 days. At inclusion, bacterial culture was positive in 40.5% (15 out of 37) of the blood cultures. Escherichia coli, Clostridium perfringens and Staphylococcus spp. were the most common isolates and were all susceptible to cefquinome. E. coli predominated in swabs from umbilical and open wound infections, and in rectal swabs E. coli. There was no correlation between IgG at inclusion and study outcome or treatment duration. The test product was very well tolerated by all of the foals following intravenous and intramuscular injection. The cefquinome formulation tested was effective and safe in the treatment of severe bacterial infections and septicaemia in foals under field conditions.
authors.affiliation: Intervet Innovation GmbH, Schwabenheim, Germany. nadja.rohdich@sp.intervet.com
authors.forename: Nadja
authors.initials: N
authors.lastname: Rohdich
authors.forename: Eva
authors.initials: E
authors.lastname: Zschiesche
authors.forename: Anja
authors.initials: A
authors.lastname: Heckeroth
authors.forename: Cornelia
authors.initials: C
authors.lastname: Wilhelm
authors.forename: Ietje
authors.initials: I
authors.lastname: Leendertse
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Thomas
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D016470:Bacteremia / Q000097:blood / Q000188:drug therapy / Q000662:veterinary; D001424:Bacterial Infections / Q000097:blood / Q000188:drug therapy / Q000662:veterinary*; D002511:Cephalosporins / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D006734:Horse Diseases / Q000097:blood / Q000188:drug therapy*; D006736:Horses; D007074:Immunoglobulin G / Q000097:blood; D007273:Injections, Intramuscular / Q000662:veterinary; D007275:Injections, Intravenous / Q000662:veterinary; D011897:Random Allocation; D018805:Sepsis / Q000097:blood / Q000188:drug therapy / Q000662:veterinary*; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D007074:Immunoglobulin G; C068212:cefquinome