The emerging role of apelin in cardiovascular disease and health.
This article focuses on a newly discovered bioactive peptide, termed apelin, as it relates to the cardiovascular system. Apelin, through its G-protein coupled receptor, seems to primarily exert effects in blood pressure control, and may play a role in heart failure and in myocardial reperfusion injury. In addition, at least some of apelin's effects appear to stem from an interaction with the renin-angiotensin system. Apelin may provide a target for drug treatment of cardiovascular disease.
Quazi
Robin
R
Department of Radiology, Barnes-Jewish Hospital, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
Palaniswamy
Chandrasekar
C
Frishman
William H
WH
D000073861:Apelin; D001794:Blood Pressure / Q000502:physiology; D002318:Cardiovascular Diseases / Q000503:physiopathology*; D002320:Cardiovascular Physiological Phenomena; D006333:Heart Failure / Q000503:physiopathology; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology*; D015428:Myocardial Reperfusion Injury / Q000503:physiopathology; D012084:Renin-Angiotensin System / Q000502:physiology
C115436:APLN protein, human; D000073861:Apelin; D036341:Intercellular Signaling Peptides and Proteins