Pd-catalyzed C=C double-bond formation by coupling of N-tosylhydrazones with benzyl halides.
Pd-catalyzed reaction of N-tosylhydrazones with benzyl halides affords di- and trisubstituted olefins in high yields with excellent stereoselectivity. This coupling reaction is supposed to proceed through a migratory insertion of Pd carbene species.
Xiao
Qing
Q
Beijing National Laboratory of Molecular Sciences (BNLMS) and Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University, Beijing 100871, China.
Ma
Jian
J
Yang
Yang
Y
Zhang
Yan
Y
Wang
Jianbo
J
D001554:Benzene / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D054879:Halogenation; D006835:Hydrazones / Q000737:chemistry*; D009584:Nitrogen / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
D006835:Hydrazones; D010165:Palladium; D002244:Carbon; D001554:Benzene; D009584:Nitrogen