title: Small-cell lung cancer arising after chemotherapy for a patient with lymphoma of pulmonary mucosa-associated lymphoid tissue-a case report.
abstract: A 76-year-old woman was admitted to our hospital with infiltrations evident in the right lower lobe on chest computed tomography. Bronchoscopic biopsy showed lymphoma of mucosa-associated lymphoid tissue (MALT). Lymphoma of the pulmonary MALT became enlarged at 8 months after diagnosis and dyspnea developed. Four courses of chemotherapy(rituximab+ cladribine)resulted in a partial response. However, 14 months after the chemotherapy, she developed multiple lung and liver tumors accompanied by disseminated intravascular coagulation syndrome. A histological examination of bone marrow aspiration showed small cell carcinoma. We administered one course of carboplatin and etoposide, but bone marrow suppression was so severe that further chemotherapy was precluded. To our knowledge, this is a rare case of small cell lung cancer arising from the treatment of lymphoma of pulmonary MALT.
authors.affiliation: Department of Medical Oncology and Immunology, Nagoya City University School of Medical Sciences, Mizuho-ku, Nagoya, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Nakao
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Oguri
authors.forename: Ken
authors.initials: K
authors.lastname: Maeno
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kusumoto
authors.forename: Chiharu
authors.initials: C
authors.lastname: Ota
authors.forename: Osamu
authors.initials: O
authors.lastname: Takakuwa
authors.forename: Takehiro
authors.initials: T
authors.lastname: Uemura
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Ozasa
authors.forename: Yasuhito
authors.initials: Y
authors.lastname: Iwashima
authors.forename: Mikinori
authors.initials: M
authors.lastname: Miyazaki
authors.forename: Takeo
authors.initials: T
authors.lastname: Kutsuna
authors.forename: Atsushi
authors.initials: A
authors.lastname: Nakamura
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Inagaki
authors.forename: Shigeki
authors.initials: S
authors.lastname: Sato
authors.forename: Ryuzo
authors.initials: R
authors.lastname: Ueda
mesh_terms: D000368:Aged; D000911:Antibodies, Monoclonal / Q000008:administration & dosage / Q000276:immunology / Q000627:therapeutic use; D058846:Antibodies, Monoclonal, Murine-Derived; D000970:Antineoplastic Agents / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001706:Biopsy; D016190:Carboplatin / Q000008:administration & dosage / Q000627:therapeutic use; D017338:Cladribine / Q000008:administration & dosage / Q000627:therapeutic use; D005047:Etoposide / Q000008:administration & dosage / Q000627:therapeutic use; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D018442:Lymphoma, B-Cell, Marginal Zone / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D009092:Mucous Membrane / Q000187:drug effects; D016609:Neoplasms, Second Primary / Q000188:drug therapy*; D000069283:Rituximab; D055752:Small Cell Lung Carcinoma / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D014057:Tomography, X-Ray Computed
chemical_list: D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D000970:Antineoplastic Agents; D017338:Cladribine; D000069283:Rituximab; D005047:Etoposide; D016190:Carboplatin