title: Role of subcutaneous abdominal fat on cardiac function and proinflammatory cytokines in premenopausal obese women.
abstract: The role of surgically removing subcutaneous fat by abdominoplasty on circulating inflammatory markers and myocardial dysfunction, evaluated by myocardial performance index (MPI), were investigated. Twenty volunteers submitted to the abdominoplasty (abdominoplasty group), and other 28 women treated by hypocaloric diet (diet group) were evaluated. Echocardiographic parameters of MPI, circulating levels of tumor necrosis factor (TNF)-alpha and interleukin (IL)-6, were performed at baseline and 2 months later. Compared with nonobese women, obese women had increased concentrations of TNF-alpha (P < 0.01), IL-6 (P < 0.01), and higher MPI (P < 0.02), indicating ventricular dysfunction. Subcutaneous fat concentrations of TNF-alpha and IL-6 were related to MPI impairment. After 60 days, waist-to hip ratio was significantly reduced in the abdominoplasty group. Anthropometric changes were accompanied by a significant decline in plasma concentrations of TNF-alpha and IL-6 levels as well as by significant improvements of MPI in abdominoplasty group compared with diet group. Abdominoplasty may represent a safe method for ameliorating cardiac function in obese women.
authors.affiliation: Department of Geriatrics and Metabolic Diseases, Second University of Naples, Italy. raffaele.marfella@unina2.it
authors.forename: Raffaele
authors.initials: R
authors.lastname: Marfella
authors.forename: Roberto
authors.initials: R
authors.lastname: Grella
authors.forename: Maria Rosaria
authors.initials: MR
authors.lastname: Rizzo
authors.forename: Michelangela
authors.initials: M
authors.lastname: Barbieri
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Grella
authors.forename: Franca
authors.initials: F
authors.lastname: Ferraraccio
authors.forename: Federico
authors.initials: F
authors.lastname: Cacciapuoti
authors.forename: Gennaro
authors.initials: G
authors.lastname: Mazzarella
authors.forename: Nicola
authors.initials: N
authors.lastname: Ferraro
authors.forename: Francesco
authors.initials: F
authors.lastname: D'Andrea
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Paolisso
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Nicoletti
mesh_terms: D000328:Adult; D016207:Cytokines / Q000032:analysis / Q000502:physiology*; D015150:Echocardiography, Doppler; D002149:Energy Intake; D005260:Female; D006321:Heart / Q000502:physiology*; D006801:Humans; D007150:Immunohistochemistry; D015850:Interleukin-6 / Q000502:physiology; D015187:Lipectomy; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000503:physiopathology*; D011184:Postoperative Period; D050507:Subcutaneous Fat, Abdominal / Q000737:chemistry / Q000502:physiology* / Q000601:surgery*; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology; D049629:Waist-Hip Ratio
chemical_list: D016207:Cytokines; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha