Dietary fat intake and risk of Parkinson's disease: a case-control study in Japan.
The present case-control study examined the relationship between dietary intake of individual fatty acids and the risk of Parkinson's disease (PD) in Japan. Included were 249 cases within 6 years of onset of PD. Controls were 368 inpatients and outpatients without a neurodegenerative disease. Information on dietary factors was collected using a validated self-administered diet history questionnaire. Compared with arachidonic acid intake in the first quartile, consumption of that in the fourth quartile was significantly related to an increased risk of PD: the adjusted odds ratio between extreme quartiles was 2.09 (95% confidence interval: 1.21-3.64, P for trend=0.008). Cholesterol intake was also significantly positively associated with the risk of PD: the adjusted odds ratio between extreme quartiles was 1.78 (95% confidence interval: 1.04-3.05, P for trend=0.01). Consumption of total fat, saturated fatty acids, monounsaturated fatty acids, n-3 polyunsaturated fatty acids, alpha-linolenic acid, eicosapentaenoic acid, docosahexaenoic acid, n-6 polyunsaturated fatty acids, and linoleic acid and the ratio of n-3 to n-6 polyunsaturated fatty acid intake were not associated with PD. Higher consumption of arachidonic acid and cholesterol may be related to an increased risk of PD.
Miyake
Yoshihiro
Y
Department of Public Health, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan. miyake-y@fukuoka-u.ac.jp
Sasaki
Satoshi
S
Tanaka
Keiko
K
Fukushima
Wakaba
W
Kiyohara
Chikako
C
Tsuboi
Yoshio
Y
Yamada
Tatsuo
T
Oeda
Tomoko
T
Miki
Takami
T
Kawamura
Nobutoshi
N
Sakae
Nobutaka
N
Fukuyama
Hidenao
H
Hirota
Yoshio
Y
Nagai
Masaki
M
D000368:Aged; D016022:Case-Control Studies; D002791:Cholesterol, Dietary; D004034:Diet Surveys; D004041:Dietary Fats; D005227:Fatty Acids; D015525:Fatty Acids, Omega-3; D005247:Feeding Behavior / Q000502:physiology*; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010300:Parkinson Disease / Q000453:epidemiology*; D012959:Socioeconomic Factors; D011795:Surveys and Questionnaires
D002791:Cholesterol, Dietary; D004041:Dietary Fats; D005227:Fatty Acids; D015525:Fatty Acids, Omega-3