Non-invasive MRI detection of individual pellets in the human stomach.
MRI is a powerful and non-invasive method to follow the fate of oral drug delivery systems in humans. Until now, most MRI studies focused on monolithic dosage forms (tablets and capsules). Small-sized multi-particulate drug delivery systems are very difficult to detect due to the poor differentiation between the delivery system and the food. A new approach was developed to overcome the described difficulties and permit the selective imaging of small multi-particulate dosage forms within the stomach. We took advantage of the different sensitivities to susceptibility artefacts of T(2)-weighted spin-echo sequences and T(2)-weighted gradient echo pulse sequences. Using a combination of both methods within a breath hold followed by a specific mathematical image analysis involving co-registration, motion correction, voxel-by-voxel comparison of the maps from different pulse sequences and graphic 2D-/3D-presentation, we were able to obtain pictures with a high sensitivity due to susceptibility effects caused by a 1% magnetite load. By means of the new imaging sequence, single pellets as small as 1mm can be detected with high selectivity within surrounding heterogeneous food in the human stomach. The developed method greatly expands the use of MRI to study the fate of oral multi-particulate drug delivery systems and their food dependency in men.
Knörgen
Manfred
M
Department of Diagnostic Radiology, Martin-Luther-University of Halle, Halle, Germany.
Spielmann
Rolf Peter
RP
Abdalla
Ahmed
A
Metz
Hendrik
H
Mäder
Karsten
K
D000284:Administration, Oral; D004304:Dosage Forms; D055590:Electromagnetic Phenomena; D052203:Ferrosoferric Oxide / Q000737:chemistry; D018565:Food-Drug Interactions; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D010316:Particle Size; D013270:Stomach; D013678:Technology, Pharmaceutical / Q000379:methods; D013997:Time Factors
D004304:Dosage Forms; D052203:Ferrosoferric Oxide