Monozygotic multiple gestation after intracytoplasmic sperm injection and preimplantation genetic diagnosis.
OBJECTIVE
To report a possible association between intracytoplasmic sperm injection (ICSI)-preimplantation genetic diagnosis (PGD) and monozygotic multiple gestation.


METHODS
Small case series.


METHODS
In vitro fertilization unit in an academic medical center.


METHODS
Three patients were treated with ICSI-PGD for sexing as well as selection against a known translocation.


METHODS
Transfer of day 4 embryos to the uterus.


METHODS
Clinical pregnancy.


RESULTS
Two pairs of monozygotic twins and a triplet pregnancy.


CONCLUSIONS
Repeated manipulation of the zona pellucida as well as extended embryo culture during ICSI-PGD treatments may result in monozygotic twin and triplet pregnancies.
Haimov-Kochman
Ronit
R
IVF Unit, Department of Obstetrics and Gynecology, Hadassah Hebrew University Medical Center, Jerusalem, Israel. kochman@hadassah.org.il
Daum
Hagit
H
Lossos
Francine
F
Aizenman
Einat
E
Werner
Marion
M
Yagel
Simcha
S
Laufer
Neri
N
Simon
Alex
A
Hurwitz
Arye
A
D000328:Adult; D046149:Embryo Culture Techniques; D004624:Embryo Transfer / Q000009:adverse effects*; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011256:Pregnancy Outcome; D018607:Pregnancy Reduction, Multifetal; D019836:Preimplantation Diagnosis; D020554:Sperm Injections, Intracytoplasmic / Q000009:adverse effects*; D014310:Triplets; D014430:Twins, Monozygotic; D015044:Zona Pellucida