title: Cleft lip and palate: a descriptive comparative, retrospective, and prospective study of patients with cleft deformities managed at 2 hospitals in Kenya.
abstract: This was a combined retrospective and prospective study in which 2 sets of results from 2 hospitals in Nairobi were analyzed and compared. The retrospective study was conducted at Kenyatta National Hospital, whereas the prospective study was conducted at Metropolitan Hospital.The main objective of the study was to establish the presentation and pattern of patients with cleft lip and palate and complications of repair at the 2 hospitals.In the retrospective arm of the study, files of all patients presenting with clefts at Kenyatta National Hospital between January 1998 and December 2007 were retrieved, and a questionnaire was filled out for each of them, whereas all patients seen and operated on for clefts at the Metropolitan Hospital from January 2007 to October 2008 were recruited into the prospective study.There was a predominance of male participants in both studies, and most clefts were on the left side. The retrospective and prospective studies had positive family history in 3.5% and 30.9%, respectively. Associated congenital malformations were 8.2% for the retrospective study and 25% for the prospective study. In both studies, the central province had the largest number of clefts, whereas the coast province had very few.Cleft lip and palate is a significant congenital malformation in Kenya, and there seems to be a higher incidence of familial tendency and associated congenital malformations than that reported elsewhere.
authors.affiliation: Department of Surgery, University of Nairobi, Nairobi, Kenya. joseph.wanjeri@uonbi.ac.ke
authors.forename: Joseph Kimani
authors.initials: JK
authors.lastname: Wanjeri
authors.forename: John Makanga
authors.initials: JM
authors.lastname: Wachira
mesh_terms: D000015:Abnormalities, Multiple; D002971:Cleft Lip / Q000145:classification / Q000235:genetics / Q000601:surgery*; D002972:Cleft Palate / Q000145:classification / Q000235:genetics / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007630:Kenya; D008297:Male; D011183:Postoperative Complications; D011446:Prospective Studies; D012111:Residence Characteristics; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors