Strength of T cell receptor signaling strikes again.
In this issue of Immunity, Gomez-Rodriguez et al. (2009) demonstrate that signaling via the Itk kinase, a component of the T cell receptor signaling pathway, is required for interleukin-17A but not interleukin-17F expression in T helper 17 cells.
Berg
Leslie J
LJ
University of Massachusetts Medical School, Worcester, MA 01655, USA. leslie.berg@umassmed.edu
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D020381:Interleukin-17 / Q000276:immunology / Q000378:metabolism; D050778:NFATC Transcription Factors / Q000276:immunology / Q000378:metabolism; D011505:Protein-Tyrosine Kinases / Q000235:genetics / Q000378:metabolism*; D011948:Receptors, Antigen, T-Cell / Q000276:immunology* / Q000378:metabolism; D015398:Signal Transduction / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology* / Q000378:metabolism
D020381:Interleukin-17; D050778:NFATC Transcription Factors; D011948:Receptors, Antigen, T-Cell; D011505:Protein-Tyrosine Kinases