title: In vitro remineralization associated with a bioerodible fluoridated resin and a fluoride varnish.
abstract: OBJECTIVE
  To examine the remineralization effects of a bioerodible fluoridated resin.
  
  
  METHODS
  36 extracted permanent molars were suspended into an artificial caries solution to create an artificial caries-like lesion. Teeth were sectioned longitudinally to obtain 100 microm sections containing the artificial caries-like lesion, then photographed with polarized light microscopy in an imbibition media of water, representing a minimum of 5% pore volume. An acid-resistant varnish was applied to the surfaces of the sections, leaving only the natural external tooth surface and caries-like lesion exposed. The external tooth surface of 12 samples had 5% sodium fluoride varnish applied, 12 samples had 5% sodium fluoride bioerodible resin applied, and the remaining samples acted as controls. The sections were returned to the tooth, placed in an artificial saliva solution and brushed daily for 30 days. The sections were removed and photographed under polarized light as before. Using a computerized imaging system, the area of the body of the lesion was measured, comparing the same section before and after the 30-day experimental period to evaluate the remineralization process.
  
  
  RESULTS
  The mean percent area remineralization (+/-SD) was: bioerodible fluoridated resin 44.1 +/- 12.1; fluoride varnish 19.1 +/- 9.2; control 2.4 +/- 3.4. ANOVA indicated a significant variance among groups (P < 0.001). Tukey's multiple comparison test demonstrated the fluoridated resin to enhance remineralization significantly greater (P < 0.001) than the fluoride varnish and control and the fluoride varnish to enhance remineralization significantly greater (P < 0.002) than the control.
authors.affiliation: Department of Pediatric Dentistry, Dental School, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, USA.
authors.forename: Royana
authors.initials: R
authors.lastname: Lin
authors.forename: Travis
authors.initials: T
authors.lastname: Hildebrand
authors.forename: Kevin J
authors.initials: KJ
authors.lastname: Donly
mesh_terms: D000180:Acrylic Resins / Q000008:administration & dosage / Q000627:therapeutic use; D002327:Cariostatic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D003731:Dental Caries / Q000473:pathology / Q000517:prevention & control; D005460:Fluorides, Topical / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008298:Maleates / Q000008:administration & dosage / Q000627:therapeutic use; D008422:Materials Testing; D008859:Microscopy, Polarization; D023861:Photography, Dental; D012464:Saliva, Artificial / Q000737:chemistry; D012822:Silicon Dioxide / Q000008:administration & dosage / Q000627:therapeutic use; D012969:Sodium Fluoride / Q000008:administration & dosage / Q000627:therapeutic use; D014089:Tooth Remineralization / Q000379:methods*; D014099:Toothbrushing
chemical_list: D000180:Acrylic Resins; D002327:Cariostatic Agents; D005460:Fluorides, Topical; D008298:Maleates; D012464:Saliva, Artificial; C023807:sodium fluoride topical preparation; C006903:carbopol 940; D012822:Silicon Dioxide; C048088:maleic acid-methacrylic acid copolymer; D012969:Sodium Fluoride