title: A clinical trial of gene therapy for chronic pain.
abstract: The first human trial of gene therapy for chronic pain, a phase 1 study of a nonreplicating herpes simplex virus (HSV)-based vector engineered to express preproenkephalin in patients with intractable pain from cancer, began enrolling subjects in December 2008. In this article, we describe the rationale underlying this potential approach to treatment of pain, the preclinical animal data in support of this approach, the design of the study, and studies with additional HSV-based vectors that may be used to develop treatment for other types of pain.
authors.affiliation: Diamyd Inc, Pittsburgh, PA, USA.
authors.forename: Darren
authors.initials: D
authors.lastname: Wolfe
authors.forename: James
authors.initials: J
authors.lastname: Wechuck
authors.forename: David
authors.initials: D
authors.lastname: Krisky
authors.forename: Marina
authors.initials: M
authors.lastname: Mata
authors.forename: David J
authors.initials: DJ
authors.lastname: Fink
mesh_terms: D002908:Chronic Disease; D002986:Clinical Trials as Topic; D015316:Genetic Therapy / Q000379:methods* / Q000639:trends*; D006801:Humans; D010146:Pain / Q000235:genetics*; D059408:Pain Management; D016896:Treatment Outcome