Towards a genetic AIDS vaccine.
We discuss a recent Nature Medicine publication by Philip Johnson and co-workers (Vector-mediated gene transfer engenders long-lived neutralizing activity and protection against SIV infection in monkeys. Nat. Med. 2009, 15: 901-906) in which an effective HIV-1 vaccine was designed that is based on gene therapy. The introduced gene produces an antibody-like immunoadhesin in the blood that neutralizes the virus.
Bordería
Antonia V
AV
Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infectious Diseases and Immunology Amsterdam, Academic Medical Center, University of Amsterdam, the Netherlands. antonio.borderia@gmail.com
Berkhout
Ben
B
D000818:Animals; D057134:Antibodies, Neutralizing / Q000235:genetics* / Q000276:immunology*; D000914:Antibodies, Viral / Q000235:genetics* / Q000276:immunology*; D015316:Genetic Therapy / Q000379:methods*; D008253:Macaca mulatta; D016097:Simian Acquired Immunodeficiency Syndrome / Q000517:prevention & control / Q000628:therapy*; D015302:Simian Immunodeficiency Virus / Q000276:immunology*
D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral