title: Pre-therapy 18F-FDG PET quantitative parameters help in predicting the response to radioimmunotherapy in non-Hodgkin lymphoma.
abstract: OBJECTIVE
  Radioimmunotherapy (RIT) is a new treatment option for patients with non-Hodgkin lymphoma (NHL). Response to RIT currently remains difficult to predict using conventional prognostic factors and could be refined using functional imaging. The goal of this work is to evaluate the value of (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET) in predicting response to Yttrium 90-labeled monoclonal antibodies for patients with NHL.
  
  
  METHODS
  Thirty-five patients with NHL who had undergone (18)F-FDG PET prior to RIT with either (90)Y-ibritumomab tiuxetan (group A; n = 17) or (90)Y-epratuzumab tetraxetan (group B; n = 18) were included in this retrospective study. Four functional criteria were determined for each tumour lesion in a given patient: maximum and mean standard uptake values (SUVmax and SUVmean), functional lesion volume (LVol) and total lesion glycolysis (TLG, product of the volume and the SUVmean). For each patient, we determined highest SUVmax and SUVmean, cumulative TLG (TLGcum) and sum of all LVol (TVol) and compared their predictive value on response (complete or partial response according to IWC) to RIT with those of conventional prognostic factors in group A and B.
  
  
  RESULTS
  A total of 154 lesions were analysed. Nineteen patients (54%) responded to RIT according to IWC. In group A, response rate was 54, 75 and 75% in patients with a SUV max <20 g/ml, a TVol <100 ml and a TLGcum <1060 g, respectively while no patient above these thresholds responded (p < 0.005). In group B, the response rate was 93% for with SUVmax <15 g/ml while no patient above this threshold responded. With TLGcum below 1,360 g, 100% of the patient responded, compared with 37% of patients whose TLGcum was above this threshold (p < 0.05). By contrast, conventional prognostic factors failed to predict response.
  
  
  CONCLUSIONS
  Our preliminary results indicate that pre-therapy (18)F-FDG PET functional parameters such as SUVmax and TLG may help predicting more accurately response to single agent Y90 based RIT.
authors.affiliation: Service de Médecine Nucléaire et Imagerie Fonctionnelle, CHU Lille, 59000, Lille, France. cazathom@hotmail.com
authors.forename: Thomas
authors.initials: T
authors.lastname: Cazaentre
authors.forename: Franck
authors.initials: F
authors.lastname: Morschhauser
authors.forename: Maximilien
authors.initials: M
authors.lastname: Vermandel
authors.forename: Nacim
authors.initials: N
authors.lastname: Betrouni
authors.forename: Thierry
authors.initials: T
authors.lastname: Prangère
authors.forename: Marc
authors.initials: M
authors.lastname: Steinling
authors.forename: Damien
authors.initials: D
authors.lastname: Huglo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D019788:Fluorodeoxyglucose F18; D005500:Follow-Up Studies; D017143:Fuzzy Logic; D006019:Glycolysis; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000000981:diagnostic imaging* / Q000473:pathology / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D016499:Radioimmunotherapy; D012189:Retrospective Studies; D016896:Treatment Outcome; D047368:Tumor Burden
chemical_list: D019788:Fluorodeoxyglucose F18