title: Asymmetric hydrogenation of enamides, alpha-enol and alpha-enamido ester phosphonates catalyzed by IndolPhos-Rh complexes.
abstract: The scope of the IndolPhos-Rh-catalyzed asymmetric hydrogenation of enamides, alpha-enol and alpha-enamido ester phosphonates, has been investigated. In addition, Taddol-based IndolPhos ligands are introduced. High activities and good to excellent enantioselectivities up to 99% ee are obtained for a broad range of structurally diverse substrates, giving important chiral products such as alpha, beta(2), and beta(3) amino acid derivatives, arylamines, and amino and hydroxy phosphonates.
authors.affiliation: Supramolecular & Homogeneous Catalysis, van't Hoff Institute for Molecular Sciences, University of Amsterdam, Nieuwe Achtergracht 166, 1018 WV Amsterdam, The Netherlands.
authors.forename: Jeroen
authors.initials: J
authors.lastname: Wassenaar
authors.forename: Joost N H
authors.initials: JN
authors.lastname: Reek
mesh_terms: D000577:Amides / Q000737:chemistry*; D002384:Catalysis; D004952:Esters; D006859:Hydrogen / Q000737:chemistry*; D063065:Organophosphonates / Q000737:chemistry*; D012211:Rhenium / Q000737:chemistry*
chemical_list: D000577:Amides; D004952:Esters; D063065:Organophosphonates; D012211:Rhenium; D006859:Hydrogen