Identification and treatment of metabolic complications in pediatric obesity.
Metabolic consequences of obesity including insulin resistance, type 2 diabetes mellitus, hyperlipidemia, hypertension, polycystic ovarian syndrome, and non-alcoholic fatty liver infiltration are rapidly emerging in the pediatric population. Identifying effective strategies for identifying and treating these obesity related comorbidities in children are crucial to the prevention of future cardiovascular disease and poor health outcomes.This review discusses the pathophysiologic connections between obesity, metabolic disease and cardiovascular risk. Current evidence and recommendations for screening and treatment for the metabolic consequences of pediatric obesity are reviewed.
Ode
Katie Larson
KL
Division of Pediatric Endocrinology, University of Minnesota, 420 Delaware Street SE, MMC 404, Minneapolis, MN 55455, USA. natha039@umn.edu
Frohnert
Brigitte I
BI
Nathan
Brandon M
BM
D002648:Child; D003924:Diabetes Mellitus, Type 2 / Q000178:diet therapy / Q000209:etiology; D005234:Fatty Liver / Q000209:etiology; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D008297:Male; D024821:Metabolic Syndrome / Q000209:etiology; D008962:Models, Theoretical; D009765:Obesity / Q000150:complications* / Q000178:diet therapy / Q000276:immunology / Q000378:metabolism; D011085:Polycystic Ovary Syndrome / Q000209:etiology