[Effects of extract of Bulbus Allii Caespitosi on cardiocyte viability of swines with myocardial reperfusion injury evaluated by (18)F-fluorodeoxyglucose positron emission tomography/computed tomography].
OBJECTIVE
To investigate the effects of extract of Bulbus Allii Caespitosi on cardiocyte viability of swines with myocardial reperfusion injury by analyzing the 18F-fluorodeoxyglucose ((18)F-FDG) position emission tomography (PET) imaging.


METHODS
Twenty-four swines were randomly divided into sham-operated group, untreated group, trimethazine group and extract of Bulbus Allii Caespitosi group. Myocardial reperfusion injury was induced by plugging the anterior descending coronary artery of swine with sacculus. Bulbus Allii Caespitosi or trimetazidine was given twice daily for 28 days. Then myocardial perfusion was detected with (18)F-FDG PET/CT and the radioactivity distribution was evaluated.


RESULTS
Compared with the untreated group, Bulbus Allii Caespitosi and trimetazidine could improve the activity of myocardial cells after myocardial infarction (P<0.01), and there were no significant differences between Bulbus Allii Caespitosi and trimetazidine (P>0.05).


CONCLUSIONS
Bulbus Allii Caespitosi can improve myocardial metabolism after ischemia and reperfusion in swines.
Zhang
Jie-mei
JM
Key Research Institute of the State Administration of Traditional Chinese Medicine, Wuhan Integrated TCM and Western Medicine Hospital, Wuhan 430022, Hubei Province, China.
Ke
Yu-he
YH
Hao
Jian-jun
JJ
Xia
Hao
H
Wu
Zhi-jian
ZJ
Tu
Xin
X
Wang
Teng
T
Wu
Bin
B
Zhu
Xu
X
Zhu
Hao
H
D000818:Animals; D019788:Fluorodeoxyglucose F18; D009203:Myocardial Infarction / Q000503:physiopathology; D015428:Myocardial Reperfusion Injury / Q000188:drug therapy* / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism*; D010936:Plant Extracts / Q000494:pharmacology*; D049268:Positron-Emission Tomography; D013552:Swine
D010936:Plant Extracts; D019788:Fluorodeoxyglucose F18