Inhalation of TGF-beta1 antibody: a new method to inhibit the airway stenosis induced by the endobronchial tuberculosis.
Tuberculous tracheobronchial stenosis is a serious clinical problem because it can cause obstructive pneumonia, dyspnea on exertion even pulmonary atelectasis of the whole lung. More than 90% of the patients with EBTB have some degree of bronchial stenosis. The interventional therapy through bronchoscopy has been used as standard treatment to deal with the scar stenosis of EBTB routinely, which have showed significant effects to keep airway open. However the scar rapid growing and restenosis can often be seen in many patients. TGF-beta1 has been demonstrated to play a very important role in scar formation. Some agents against TGF-beta1 have been proved to inhibit the scar growing effectively. The level of TGF-beta elevated in the BALF of EBTB patients suggests TGF-beta be related to the pathogenesis of stenosis induced by EBTB. We hypothesize that inhalation of TGF-beta1 antibody can neutralize the local TGF-beta and reduce the level of this kind of cytokine so as to prevent the scar formation partially, and find a new pathway to deal with this tough clinical problem.
Zhang
Jingxi
J
Department of Respiratory Medicine, Changhai Hospital, The Second Military Medical University, 168 Changhai Road, Yangpu District, Shanghai 200433, China.
Li
Qiang
Q
Bai
Chong
C
Han
Yiping
Y
Huang
Yi
Y
D000280:Administration, Inhalation; D000402:Airway Obstruction / Q000473:pathology*; D000906:Antibodies / Q000008:administration & dosage*; D001982:Bronchial Diseases / Q000473:pathology*; D001992:Bronchoalveolar Lavage Fluid; D003251:Constriction, Pathologic / Q000473:pathology*; D006801:Humans; D008962:Models, Theoretical; D053773:Transforming Growth Factor beta1 / Q000276:immunology*; D014376:Tuberculosis / Q000473:pathology*
D000906:Antibodies; D053773:Transforming Growth Factor beta1