title: A novel method to study the skin-lightening effect of topical materials.
abstract: Skin without significant dyschromia is an aesthetic requirement for people worldwide. There are several in vitro methods to determine the whitening potential of actives; however, the in vivo testing of skin whiteners is a long and expensive process. We have designed a rapid clinical method to screen potential skin whiteners using a UV-induced skin tan as a model. Small areas of identical suntan are repeatably induced on the skin, and treatment of these sites allows rapid screening of several skin whiteners within the course of a month. The method provides reproducible results and valuable information about the potential skin-lightening activity of topical preparations.
authors.affiliation: Estee Lauder Companies, Melville, NY 11747, USA.
authors.forename: Neelam
authors.initials: N
authors.lastname: Muizzuddin
authors.forename: Kenneth D
authors.initials: KD
authors.lastname: Marenus
authors.forename: Thomas
authors.initials: T
authors.lastname: Mammone
authors.forename: Daniel H
authors.initials: DH
authors.lastname: Maes
mesh_terms: D000287:Administration, Topical; D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012867:Skin / Q000187:drug effects*; D012880:Skin Pigmentation