title: Nucleophilic capture of the imino-quinone methide type intermediates generated from 2-aminothiazol-5-yl carbinols.
abstract: Generation of imino-quinone methide type intermediates from 2-aminothiazole-5-carbinols using alkylsulfonic acids in nitromethane followed by trapping with a wide range of nucleophiles effects C-C, C-O, C-N, C-S, and C-P bond formation.
authors.affiliation: Department of Discovery Chemistry, Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, Connecticut 06492, USA. mark.saulnier@bms.com
authors.forename: Mark G
authors.initials: MG
authors.lastname: Saulnier
authors.forename: Marco
authors.initials: M
authors.lastname: Dodier
authors.forename: David B
authors.initials: DB
authors.lastname: Frennesson
authors.forename: David R
authors.initials: DR
authors.lastname: Langley
authors.forename: Dolatrai M
authors.initials: DM
authors.lastname: Vyas
mesh_terms: D007097:Imines / Q000737:chemistry*; D045563:Indolequinones / Q000138:chemical synthesis* / Q000737:chemistry; D000432:Methanol / Q000031:analogs & derivatives* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism; D013844:Thiazoles / Q000737:chemistry*
chemical_list: C546265:2-aminothiazol-5-yl carbinol; D007097:Imines; D045563:Indolequinones; D013844:Thiazoles; C068040:quinone methide; D000432:Methanol