Rif proteins take to the RhoD: Rho GTPases at the crossroads of actin dynamics and membrane trafficking.
The Rif and RhoD proteins belong to the Rho subfamily of small GTPases. Rif and RhoD have for too long remained in the shadows of the better known Rho GTPases Cdc42, Rac1 and RhoA. With this review article, our aim is to provide the currently available information regarding Rif and RhoD. Taken together, the data available to date indicate that Rif and RhoD have unique roles in the regulation of actin dynamics, and that RhoD can link actin reorganisation to endosomal vesicle transport.
Gad
Annica K B
AK
Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
Aspenström
Pontus
P
D000199:Actins / Q000737:chemistry / Q000378:metabolism*; D000595:Amino Acid Sequence; D006801:Humans; D008969:Molecular Sequence Data; D016415:Sequence Alignment; D013379:Substrate Specificity; D020741:rho GTP-Binding Proteins / Q000378:metabolism* / Q000502:physiology
D000199:Actins; C105243:RHOD protein, human; C419867:RHOF protein, human; D020741:rho GTP-Binding Proteins