title: Serum adipokine levels in patients with systemic lupus erythematosus.
abstract: In patients with systemic lupus erythematosus (SLE) metabolic alterations are often observed, which may be due to either the disease, the genetic background or the treatment. We studied the serum levels of the adipokines leptin, adiponectin, resistin, visfatin and ghrelin in patients with SLE and controls. Leptin levels were lower and adiponectin, ghrelin and visfatin levels were higher in the patients. No significant differences were encountered for resistin. The values of adipokines were independent of treatment, even after correction for body mass index. Inverse correlations were found among leptin and adiponectin, ghrelin and visfatin. We conclude that adipokines are involved in the metabolic imbalance of patients with SLE.
authors.affiliation: Instituto de Inmunología, University Central de Venezuela, Apartado 50109, Caracas, 1050-A, Venezuela.
authors.forename: Juan B
authors.initials: JB
authors.lastname: De Sanctis
authors.forename: Mercedes
authors.initials: M
authors.lastname: Zabaleta
authors.forename: Nicolás E
authors.initials: NE
authors.lastname: Bianco
authors.forename: Jenny V
authors.initials: JV
authors.lastname: Garmendia
authors.forename: Liliana
authors.initials: L
authors.lastname: Rivas
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D015992:Body Mass Index; D005260:Female; D054439:Ghrelin / Q000097:blood*; D006801:Humans; D020738:Leptin / Q000097:blood*; D008180:Lupus Erythematosus, Systemic / Q000097:blood*; D008297:Male; D054409:Nicotinamide Phosphoribosyltransferase / Q000097:blood*; D052243:Resistin / Q000097:blood*
chemical_list: D052242:Adiponectin; D054439:Ghrelin; D020738:Leptin; D052243:Resistin; D054409:Nicotinamide Phosphoribosyltransferase