title: Differential changes in serum uric acid concentrations in sibutramine promoted weight loss in diabetes: results from four weeks of the lead-in period of the SCOUT trial.
abstract: OBJECTIVE
  Elevated levels of serum uric acid are associated with an increased risk of cardiovascular morbidity and mortality. The response of uric acid to weight loss therapy (lifestyle plus sibutramine) in an overweight and obese cardiovascular high risk population was studied.
  
  
  RESULTS
  Data from a four week single-blind lead-in period of the Sibutramine Cardiovascular OUTcomes (SCOUT) study were analyzed. 2584 patients (24%) had diabetes mellitus (DM) only, 1748 (16%) had cardiovascular disease (CVD) only and 6397 (60%) had both DM + CVD. Uric acid concentrations (mean +/- standard deviation) at screening were significantly higher among patients with CVD compared to patients without CVD (p < 0.0001): 369 +/- 86 mumol/L, 374 +/- 98 mumol/L and 342 +/- 87 mumol/L in CVD only, CVD+DM and DM only groups, respectively. During treatment uric acid decreased significantly more in patients without DM (p < 0.0001): -15.0 mumol/L (95% confidence interval -17.7;-12.4), -4.6 mumol/L (-6.2;-3.0), and -6.6 mumol/L (-8.7;-4.5) in CVD only, CVD+DM, and DM only groups, respectively. In patients who failed to lose weight, sibutramine induced lower uric acid levels, but greater weight loss and diabetes were associated with smaller falls in blood uric acid levels; decreasing fasting and urinary glucose concentrations in diabetes were associated with increases in uric acid levels.
  
  
  CONCLUSIONS
  A four week daily intake of sibutramine and life style changes was associated with significant reductions in mean uric acid levels. Changes in renal glucose load in diabetes seem to counteract a potential uricosuric effect of sibutramine.
  
  
  BACKGROUND
  The trial is registered at ClinicalTrial.gov number: NCT00234832.
authors.affiliation: Department of Cardiology, Gentofte University Hospital, Hellerup, Denmark. ca@heart.dk.
authors.forename: Charlotte
authors.initials: C
authors.lastname: Andersson
authors.forename: Peter
authors.initials: P
authors.lastname: Weeke
authors.forename: Bente
authors.initials: B
authors.lastname: Brendorp
authors.forename: Lars
authors.initials: L
authors.lastname: Køber
authors.forename: Emil L
authors.initials: EL
authors.lastname: Fosbøl
authors.forename: Arya M
authors.initials: AM
authors.lastname: Sharma
authors.forename: Nick
authors.initials: N
authors.lastname: Finer
authors.forename: Ian D
authors.initials: ID
authors.lastname: Caterson
authors.forename: Richard A
authors.initials: RA
authors.lastname: Rode
authors.forename: Philip T
authors.initials: PT
authors.lastname: James
authors.forename: Christian
authors.initials: C
authors.lastname: Torp-Pedersen