title: Aspergillusol A, an alpha-glucosidase inhibitor from the marine-derived fungus Aspergillus aculeatus.
abstract: A new tyrosine-derived metabolite, aspergillusol A (4), was isolated on a gram scale, together with a methyl ester of 4-hydroxyphenylpyruvic acid oxime (5) and secalonic acid A, from the marine-derived fungus Aspergillus aculeatus CRI323-04. The tetraol in 4 was identified as erythritol by comparison of the 1H NMR spectrum of its benzoylated derivative with those of benzoylated erythritol (7) and D-threitol (8), as well as by cellulose-based chiral HPLC analysis. Aspergillusol A (4) selectively inhibited alpha-glucosidase from the yeast Saccharomyces cerevisiae, but it was inactive toward the alpha-glucosidase from the bacterium Bacillus stearothermophilus.
authors.affiliation: Chulabhorn Graduate Institute and the Center for Environmental Health, Toxicology and Management of Chemicals (ETM), Chemical Biology Program, Vibhavadi-Rangsit Road, Laksi, Bangkok 10210, Thailand.
authors.forename: Nattha
authors.initials: N
authors.lastname: Ingavat
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Dobereiner
authors.forename: Suthep
authors.initials: S
authors.lastname: Wiyakrutta
authors.forename: Chulabhorn
authors.initials: C
authors.lastname: Mahidol
authors.forename: Somsak
authors.initials: S
authors.lastname: Ruchirawat
authors.forename: Prasat
authors.initials: P
authors.lastname: Kittakoop
mesh_terms: D001230:Aspergillus / Q000737:chemistry*; D001411:Geobacillus stearothermophilus / Q000187:drug effects / Q000201:enzymology*; D065089:Glycoside Hydrolase Inhibitors; D008386:Marine Biology; D015394:Molecular Structure; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000201:enzymology*; D013237:Stereoisomerism; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D044004:Xanthones / Q000302:isolation & purification
chemical_list: D065089:Glycoside Hydrolase Inhibitors; D044004:Xanthones; C545427:aspergillusol A; D014443:Tyrosine; C009218:secalonic acid