Solid phase synthesis of acylglycine human metabolites.
Acylglycines represents a large and important class of human metabolites. They are often used in medicine to identify fatty acid oxidation disorders. A highly efficient solid phase synthesis approach to obtain these clinically important compounds is developed via coupling reaction between glycine-preloaded Wang resin and a set of carboxylic acids. The developed methodology facilitates the preparation of several structurally-diverse acylglycines with high yields and purity.
Perez-Pineiro
Rolando
R
Department of Biological Sciences, University of Alberta, Edmonton, AB, Canada. perezpin@ualberta.ca
Dong
Ying Wei
YW
Wishart
David S
DS
D005998:Glycine / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000378:metabolism*; D006801:Humans; D015394:Molecular Structure; D013237:Stereoisomerism
D005998:Glycine