[Connective tissue growth factor (CTGF): a key factor in the onset and progression of kidney damage].
Connective tissue growth factor (CTGF) is increased in several pathologies associated with fibrosis, including multiple renal diseases. CTGF is involved in biological processes such as cell cycle regulation, migration, adhesion and angiogenesis. Its expression is regulated by various factors involved in renal damage, such as transforming growth factor- , Angiotensin II, high concentrations of glucose and cellular stress. CTGF is involved in the initiation and progression of renal damage to be able to induce an inflammatory response and promote fibrosis, identified as a potential therapeutic target in the treatment of kidney diseases. In this paper we review the main actions of CTGF in renal disease, the intracellular action mechanisms and therapeutic strategies for its blocking.
Sánchez-López
E
E
Laboratorio de Biología celular en Enfermedades Renales, Universidad Autónoma de Madrid, Madrid, Spain.
Rodrigues Díez
R
R
Rodríguez Vita
J
J
Rayego Mateos
S
S
Rodrigues Díez
R R
RR
Rodríguez García
E
E
Lavoz Barria
C
C
Mezzano
S
S
Egido
J
J
Ortiz
A
A
Ruiz-Ortega
M
M
Selgas
R
R
D055513:Connective Tissue Growth Factor / Q000502:physiology*; D018450:Disease Progression; D006801:Humans; D007674:Kidney Diseases / Q000209:etiology*
D055513:Connective Tissue Growth Factor