title: Mapping of quantitative trait loci affecting classical scrapie incubation time in a population comprising several generations of scrapie-infected sheep.
abstract: Although susceptibility to scrapie is largely controlled by the PrP gene, the role of other genes that affect scrapie resistance in sheep is now confirmed. Following the detection of quantitative trait loci (QTL) on chromosomes 6 and 18 in a half-sib family with an ARQ/VRQ susceptible PrP genotype, the whole pedigree of a naturally infected flock was investigated to confirm these QTL regions in different PrP genotypes. The present study has allowed us to confirm the QTL on chromosome 18, and to demonstrate the QTL effects in several PrP genotypes.
authors.affiliation: INRA, UR631, Amélioration Génétique des Animaux, BP52627, 31326 Castanet-Tolosan, France. Moreno@toulouse.inra.fr
authors.forename: Carole R
authors.initials: CR
authors.lastname: Moreno
authors.forename: Katayoun
authors.initials: K
authors.lastname: Moazami-Goudarzi
authors.forename: Stephanie
authors.initials: S
authors.lastname: Briand
authors.forename: Christèle
authors.initials: C
authors.lastname: Robert-Granié
authors.forename: Jean Louis
authors.initials: JL
authors.lastname: Weisbecker
authors.forename: Pascal
authors.initials: P
authors.lastname: Laurent
authors.forename: Edmond-Paul
authors.initials: EP
authors.lastname: Cribiu
authors.forename: Christopher S
authors.initials: CS
authors.lastname: Haley
authors.forename: Olivier
authors.initials: O
authors.lastname: Andréoletti
authors.forename: Stephen C
authors.initials: SC
authors.lastname: Bishop
authors.forename: Ricardo
authors.initials: R
authors.lastname: Pong-Wong
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D005260:Female; D020022:Genetic Predisposition to Disease; D008297:Male; D010375:Pedigree; D018621:PrPC Proteins / Q000235:genetics; D040641:Quantitative Trait Loci; D012608:Scrapie / Q000235:genetics* / Q000473:pathology; D012756:Sheep / Q000235:genetics*; D013997:Time Factors
chemical_list: D018621:PrPC Proteins