title: Development of a new zirconia-toughened alumina: promising mechanical properties and absence of in vitro carcinogenicity.
abstract: High purity alumina as well as zirconia ceramics have been widely used as orthopaedic implant biomaterials and dental devices displaying optimal, but sometimes exclusive, mechanical properties. In order to combine the advantages of alumina and zirconia ceramic materials different types of composites have been developed in which either zirconia is dispersed in an alumina matrix or vice versa. Orthopaedic and dental implant biomaterials are expected to be in contact with living tissues for a long period of time and their long term toxicity must be carefully evaluated. In this study we report the development of a high performance chromia-doped zirconia toughened alumina (ZTA) material which displays promising mechanical properties in terms of hardness, strength and fracture toughness that make it suitable for prosthesis even for small joints. The long-term biocompatibility of this material was also evaluated, mainly in terms of DNA damage, mutagenicity and cancerogenetic potential in mammalian cells. The results obtained suggest that this new ZTA material does not display any longterm carcinogenic effect and it is suitable for biomedical applications from a cancerogenetic point of view. In conclusion, we report the development of a new chromia-doped ZTA material with interesting properties, both from a mechanical and a biocompatibility point of view which warrant further studies on its suitability as a candidate biomaterial for orthopaedic implants and dental devices.
authors.affiliation: Department of Orthopaedics and Traumatology, Catholic University, Rome, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Maccauro
authors.forename: G
authors.initials: G
authors.lastname: Bianchino
authors.forename: S
authors.initials: S
authors.lastname: Sangiorgi
authors.forename: G
authors.initials: G
authors.lastname: Magnani
authors.forename: D
authors.initials: D
authors.lastname: Marotta
authors.forename: P F
authors.initials: PF
authors.lastname: Manicone
authors.forename: L
authors.initials: L
authors.lastname: Raffaelli
authors.forename: P
authors.initials: P
authors.lastname: Rossi Iommetti
authors.forename: A
authors.initials: A
authors.lastname: Stewart
authors.forename: A
authors.initials: A
authors.lastname: Cittadini
authors.forename: A
authors.initials: A
authors.lastname: Sgambato
mesh_terms: D000537:Aluminum Oxide / Q000737:chemistry* / Q000633:toxicity; D000818:Animals; D001672:Biocompatible Materials; D015197:Carcinogenicity Tests; D002460:Cell Line; D002516:Ceramics / Q000737:chemistry* / Q000633:toxicity; D020552:Comet Assay; D019245:Compressive Strength; D004249:DNA Damage; D017266:Dental Prosthesis; D006244:Hardness; D008422:Materials Testing; D051379:Mice; D009983:Orthopedic Equipment; D011474:Prosthesis Design; D013718:Tensile Strength; D013997:Time Factors; D015040:Zirconium / Q000737:chemistry* / Q000633:toxicity
chemical_list: D001672:Biocompatible Materials; D015040:Zirconium; D000537:Aluminum Oxide; C028541:zirconium oxide