title: Effectiveness of adalimumab in treating patients with active psoriatic arthritis and predictors of good clinical responses for arthritis, skin and nail lesions.
abstract: OBJECTIVE
  To evaluate the effectiveness of adalimumab in patients with psoriatic arthritis (PsA) and identify predictors of good clinical response for joint and skin lesions.
  
  
  METHODS
  Patients received adalimumab 40 mg every other week in addition to standard therapy in this prospective, 12-week, open-label, uncontrolled study. Four definitions of good clinical response were used: > or =50% improvement in American College of Rheumatology response criteria (ACR50), good response according to European League Against Rheumatism (EULAR) guidelines, a > or =3-grade improvement in Physician Global Assessment of psoriasis (PGA) and a > or =50% improvement in the Nail Psoriasis Severity Index (NAPSI). Response predictors were determined by logistic regression with backward elimination (selection level was 5%).
  
  
  RESULTS
  Of 442 patients, 94% completed 12 weeks of treatment. At week 12, 74%, 51% and 32% of the patients had achieved ACR20, 50 and 70, respectively; 87% and 61% experienced moderate and good responses according to EULAR criteria, respectively. The percentage of patients with PGA results of "clear/almost clear" increased from 34% (baseline) to 68%. The mean NAPSI score was reduced by 44%. No new safety signals were detected. A lower Health Assessment Questionnaire Disability Index (HAQ-DI) score, greater pain assessment, male sex and absence of systemic glucocorticoid therapy were strongly associated with achievement of ACR50 and good response according to EULAR criteria. In addition, greater C-reactive protein concentration and polyarthritis predicted ACR50, and non-involvement of large joints predicted a good response according to EULAR criteria.
  
  
  CONCLUSIONS
  Adalimumab was effective in patients with PsA. Lower impairment of physical function, greater pain, male sex and no systemic treatment with glucocorticoids were factors that increased the chance of achieving a good clinical response.
authors.affiliation: University Hospital Gent, Belgium. filip.vandenbosch@ugent.be
authors.forename: F
authors.initials: F
authors.lastname: Van den Bosch
authors.forename: B
authors.initials: B
authors.lastname: Manger
authors.forename: P
authors.initials: P
authors.lastname: Goupille
authors.forename: N
authors.initials: N
authors.lastname: McHugh
authors.forename: E
authors.initials: E
authors.lastname: Rødevand
authors.forename: P
authors.initials: P
authors.lastname: Holck
authors.forename: R F
authors.initials: RF
authors.lastname: van Vollenhoven
authors.forename: M
authors.initials: M
authors.lastname: Leirisalo-Repo
authors.forename: O
authors.initials: O
authors.lastname: Fitzgerald
authors.forename: M
authors.initials: M
authors.lastname: Kron
authors.forename: M
authors.initials: M
authors.lastname: Frank
authors.forename: S
authors.initials: S
authors.lastname: Kary
authors.forename: H
authors.initials: H
authors.lastname: Kupper
mesh_terms: D000068879:Adalimumab; D000328:Adult; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D061067:Antibodies, Monoclonal, Humanized; D018501:Antirheumatic Agents / Q000627:therapeutic use*; D015535:Arthritis, Psoriatic / Q000188:drug therapy*; D003879:Dermatologic Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009260:Nail Diseases / Q000188:drug therapy; D011379:Prognosis; D011446:Prospective Studies; D011565:Psoriasis / Q000188:drug therapy; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D018501:Antirheumatic Agents; D003879:Dermatologic Agents; D000068879:Adalimumab