title: Structure casts light on mtDNA replication.
abstract: In this issue, Lee et al. (2009) present a crystal structure of the human mitochondrial DNA polymerase (POLgamma). The structure of this heterotrimeric enzyme lays a foundation for understanding how POLgamma mutations cause human mitochondrial disease and why some antiviral nucleoside analogs cause cellular toxicity.
authors.affiliation: Department of Medical Biochemistry and Cell Biology, Göteborg University, SE-405 30 Göteborg, Sweden. maria.falkenberg@medkem.gu.se
authors.forename: Maria
authors.initials: M
authors.lastname: Falkenberg
authors.forename: Nils-Göran
authors.initials: NG
authors.lastname: Larsson
mesh_terms: D000074002:DNA Polymerase gamma; D004261:DNA Replication; D004272:DNA, Mitochondrial / Q000378:metabolism*; D004259:DNA-Directed DNA Polymerase / Q000737:chemistry*; D006801:Humans; D008928:Mitochondria / Q000235:genetics / Q000378:metabolism
chemical_list: D004272:DNA, Mitochondrial; D000074002:DNA Polymerase gamma; D004259:DNA-Directed DNA Polymerase