title: Joint reviews and inspections: strategic forms of collaboration for strengthening the regulatory oversight of vaccine clinical trials in Africa.
abstract: Vaccine developers are required to submit a clinical trial application to the authorities in each country where a clinical trial will be conducted. The application has to be made both to the relevant Ethics Committees and to the National Regulatory Authorities, and only after appropriate clearance by both can a clinical trial commence. This paper describes two specific strategies, joint reviews of vaccine clinical trial applications and joint inspections of clinical trial sites by groups of countries, as part of a WHO initiative to strengthen capacity for the regulatory oversight of clinical trials in Africa. Significantly, the joint reviews and inspections contributed to reinforcing the capacities of the regulatory authorities as well as defining an efficient process to maximize the quality of the reviews and minimize undue delays. Finally we will suggest complementary mechanisms to overcome the potential limitations of joint reviews and inspections.
authors.affiliation: Quality Safety and Standards, Department of Immunization, Vaccines and Biologicals, WHO, Geneva, Switzerland.
authors.forename: Diadié
authors.initials: D
authors.lastname: Maïga
authors.forename: Bartholomew Dicky
authors.initials: BD
authors.lastname: Akanmori
authors.forename: Liliana
authors.initials: L
authors.lastname: Chocarro
mesh_terms: D000349:Africa; D002986:Clinical Trials as Topic; D006801:Humans; D014612:Vaccines / Q000592:standards*
chemical_list: D014612:Vaccines