title: Nitric oxide measurement in chronic cough.
abstract: Chronic cough is a common symptom-based diagnostic challenge for primary care physicians and respiratory specialists. Measurement of exhaled nitric oxide is a convenient, reproducible, and inexpensive point-of-service test. It can simplify the evaluation process of chronic cough by providing information regarding the state of airway inflammation. If exhaled nitric oxide is elevated, this is predictive of a favorable response to inhaled corticosteroids. This has the effect of reducing empirical trials for cough-variant asthma or eosinophilic bronchitis. The inclusion of exhaled nitric oxide in the diagnostic approach to chronic cough should be considered.
authors.affiliation: Department of Medicine, Division of Pulmonary and Critical Care, Mayo Clinic Rochester, 200 First Street Gonda 18-417, Rochester, MN, 55905, USA, lim.kaiser@mayo.edu.
authors.forename: Kaiser G
authors.initials: KG
authors.lastname: Lim
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D001249:Asthma / Q000150:complications / Q000175:diagnosis; D015415:Biomarkers / Q000032:analysis; D001944:Breath Tests; D001991:Bronchitis / Q000150:complications / Q000175:diagnosis; D016085:Bronchoconstrictor Agents; D002908:Chronic Disease; D003371:Cough / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D016210:Methacholine Chloride; D009569:Nitric Oxide / Q000032:analysis*; D011657:Pulmonary Eosinophilia / Q000150:complications / Q000175:diagnosis
chemical_list: D000305:Adrenal Cortex Hormones; D015415:Biomarkers; D016085:Bronchoconstrictor Agents; D016210:Methacholine Chloride; D009569:Nitric Oxide