[Mouse stroke models and strains-related differences in susceptibility to cerebral ischemia].
Mouse stroke models provide experiment basis for study of the mechanisms of cell death and neural repair, and the neuroprotective effect of new drugs. There are at least three models of middle cerebral artery occlusion (MCAO) routinely used in experimental study. These models vary widely in their application in study of cell death or neural repair, and simulation of human diseases. This review article is focused on the characteristics of three mouse MCAO models and the strains-related differences in susceptibility to cerebral ischemia.
Liu
Hui-Qin
HQ
Department of Neurology, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310009, China.
Liu
Jian-Ren
JR
Ding
Mei-Ping
MP
D000818:Animals; D002545:Brain Ischemia; D004195:Disease Models, Animal; D020244:Infarction, Middle Cerebral Artery / Q000145:classification; D051379:Mice; D013045:Species Specificity; D020521:Stroke