title: Perianal fistulae in Crohn's Disease: current and future approaches to treatment.
abstract: : affecting sphincter integrity and continence. Traditional surgical and medical approaches are not without their limitations and may result in either comorbidity, such as fecal incontinence, or incomplete healing of the fistulae. Over the last 2 decades these limitations have led to a paradigm shift toward the use of biomaterials, and more recently cell-based therapies, which have met with variable degrees of success. This review discusses the traditional and current methods of treatment, as well as emerging and possible alternative approaches that may improve fistula healing.
authors.affiliation: Biomaterials and Tissue Engineering Group, Centre for Gastroenterology & Nutrition, University College London, UK.
authors.forename: Hussila
authors.initials: H
authors.lastname: Keshaw
authors.forename: Keen S
authors.initials: KS
authors.lastname: Foong
authors.forename: Alastair
authors.initials: A
authors.lastname: Forbes
authors.forename: Richard M
authors.initials: RM
authors.lastname: Day
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D003424:Crohn Disease / Q000150:complications* / Q000628:therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D012003:Rectal Fistula / Q000209:etiology* / Q000628:therapy*
chemical_list: D000900:Anti-Bacterial Agents; D007166:Immunosuppressive Agents