title: Secondary alcohol hemiacetal formation: an in situ carbonyl activation strategy.
abstract: A simple strategy was studied for the reversible nucleophilic addition of secondary alcohols to carbonyl-based receptors to form hemiacetals. It involves the in situ binding of neighboring Brønsted and Lewis acids activators. The addition reaction was successfully observed by UV-vis spectroscopy, thereby laying the groundwork for alcohol optical sensor design.
authors.affiliation: Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, Texas 78712, USA.
authors.forename: Lei
authors.initials: L
authors.lastname: You
authors.forename: Eric V
authors.initials: EV
authors.lastname: Anslyn
mesh_terms: D000080:Acetals / Q000138:chemical synthesis* / Q000737:chemistry; D000438:Alcohols / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D000080:Acetals; D000438:Alcohols; D007659:Ketones