Benzothiazoles as Rho-associated kinase (ROCK-II) inhibitors.
A series of benzothiazole derivatives as ROCK inhibitors have been discovered. Compounds with good biochemical and cellular potency, and sufficient kinase selectivity have been identified.
Yin
Yan
Y
Translational Research Institute and Department of Molecular Therapeutics, The Scripps Research Institute, Florida, 130 Scripps Way #2A1, Jupiter, FL 33458, United States.
Lin
Li
L
Ruiz
Claudia
C
Cameron
Michael D
MD
Pocas
Jennifer
J
Grant
Wayne
W
Schröter
Thomas
T
Chen
Weimin
W
Duckett
Derek
D
Schürer
Stephan
S
Lograsso
Philip
P
Feng
Yangbo
Y
D052160:Benzothiazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D015195:Drug Design; D015394:Molecular Structure; D047428:Protein Kinase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D054460:rho-Associated Kinases / Q000037:antagonists & inhibitors*
D052160:Benzothiazoles; D047428:Protein Kinase Inhibitors; D054460:rho-Associated Kinases