One-Pot Synthesis of New Symmetric and Asymmetric Xanthene Dyes.
Symmetric and asymmetric xanthene dyes have been prepared by a convenient one-step procedure from aldehyde and diol or m-aminophenol precursors using concentrated phosphoric acid as a solvent. This protocol provides access to water-soluble dyes with large Stoke's shifts and far-red fluorescence emission. These compounds are envisioned as components of fluorescence-based sensors for a variety of imaging applications.
Hilderbrand
Scott A
SA
Center for Molecular Imaging Research, Massachusetts General Hospital/Harvard Medical School, Charlestown, Massachusetts 02129, USA.
Weissleder
Ralph
R