title: The influence of 1-10 kD fraction from brains of the hibernating ground squirrel and the Yakut horse on proliferation and protein synthesizing system of Ehrlich ascitic carcinoma cells.
abstract: The experimental data presented in the work testify to the cytostatic activity of 1-10 kD polypeptide fractions from brains of the hibernating ground squirrel and the Yakut horse towards Ehrlich ascitic carcinoma (EAC) cells. The experiments on the investigation of the inhibiting influence of 1-10 kD fractions from tissues of the hibernating and cold-adapted animals on protein-synthesizing system of EAC cells allow us to conclude that the cytostatic effect of the fractions is effected at the genetic level in the tumor cells.
authors.affiliation: Institute for Problems of Cryobiology and Cryomedicine of the National Akademy of Sciences of Ukraine, Kharkov, Ukraine. ivanou@rambler.ru
authors.forename: A K
authors.initials: AK
authors.lastname: Gulevsky
authors.forename: V I
authors.initials: VI
authors.lastname: Grischenko
authors.forename: O S
authors.initials: OS
authors.lastname: Tereschenko
authors.forename: I J
authors.initials: IJ
authors.lastname: Shchenyavcky
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism* / Q000473:pathology*; D049109:Cell Proliferation / Q000187:drug effects*; D003080:Cold Temperature; D004247:DNA / Q000378:metabolism; D006605:Hibernation / Q000502:physiology*; D006736:Horses; D010455:Peptides / Q000378:metabolism / Q000494:pharmacology*; D021122:Protein Subunits / Q000378:metabolism / Q000494:pharmacology; D011506:Proteins / Q000378:metabolism*; D012313:RNA / Q000378:metabolism; D012589:Sciuridae
chemical_list: D010455:Peptides; D021122:Protein Subunits; D011506:Proteins; D012313:RNA; D004247:DNA