[Cardioprotective effects of fluorine-containing activator of adenosine triphosphate-dependent potassium channels flokalin].
In experiments on isolated Langendorff perfused hearts of guinea pig with modeling of ischemia (20 min) and reperfusion (40 min) the cardioprotective effects of drug form of new fluorine-containing K(ATP) channels opener flokalin were shown. Preliminary preischemic perfusion of isolated heart with new form of flokalin (5 M) for 5 minutes significantly improved the recovery of contractive function of ischemic myocardium at reperfusion. In particular, it considerably reduced time of ischemic heart contract recovery from the beginning of reperfusion. Recovery of systolic and developed pressure was improved and the increasing of end-diastolic pressure in left ventricle of heart was prevented. Vasodilatoric and antiarrhythmic properties of new drug form of flokalin can assist to it's cardioprotective effects. The vasoconstriction of coronary vessels was prevented and number of extrasystoles at reperfusion of ischemic heart was decreased.
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D000818:Animals; D002316:Cardiotonic Agents / Q000737:chemistry / Q000494:pharmacology*; D005461:Fluorine / Q000737:chemistry*; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects*; D006334:Heart Function Tests; D066298:In Vitro Techniques; D054086:KATP Channels / Q000378:metabolism*; D008297:Male; D015425:Myocardial Reperfusion; D015428:Myocardial Reperfusion Injury / Q000378:metabolism / Q000517:prevention & control*; D009206:Myocardium / Q000378:metabolism*; D020110:Pinacidil / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology
D002316:Cardiotonic Agents; D054086:KATP Channels; C559719:N-(4-difluoromethoxyphenyl)-N'-pinacolyl-N''-cyanoguanidine; D005461:Fluorine; D020110:Pinacidil