title: Mechanism of noradrenaline-induced stimulation of Na-K ATPase activity in the rat brain: implications on REM sleep deprivation-induced increase in brain excitability.
abstract: Rapid eye movement (REM) sleep is a unique phenomenon expressed in all higher forms of animals. Its quantity varies in different species and with ageing; it is also affected in several psycho-somatic disorders. Several lines of studies showed that after REM sleep loss, the levels of noradrenaline (NA) increase in the brain. The NA in the brain modulates neuronal Na-K ATPase activity, which helps maintaining the brain excitability status. The detailed mechanism of increase in NA level after REM sleep loss and the effect of NA on stimulation of Na-K ATPase in the neurons have been discussed. The findings have been reviewed and discussed with an aim to understand the role of REM sleep in maintaining brain excitability status.
authors.affiliation: School of Life Sciences, Jawaharlal Nehru University, New Delhi, 110067, India. remsbnm@yahoo.com
authors.forename: Birendra Nath
authors.initials: BN
authors.lastname: Mallick
authors.forename: Sudhuman
authors.initials: S
authors.lastname: Singh
authors.forename: Abhishek
authors.initials: A
authors.lastname: Singh
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism / Q000503:physiopathology*; D020013:Calcium Signaling; D002462:Cell Membrane / Q000378:metabolism; D004789:Enzyme Activation; D019054:Evoked Potentials, Motor / Q000502:physiology; D006801:Humans; D007527:Isoenzymes; D009474:Neurons / Q000502:physiology*; D009638:Norepinephrine / Q000032:analysis / Q000502:physiology*; D011941:Receptors, Adrenergic / Q000378:metabolism; D012892:Sleep Deprivation / Q000503:physiopathology*; D012895:Sleep, REM / Q000502:physiology*; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism*
chemical_list: D007527:Isoenzymes; D011941:Receptors, Adrenergic; D000254:Sodium-Potassium-Exchanging ATPase; D009638:Norepinephrine