Draxin, a repulsive axon guidance protein, is involved in hippocampal development.
The hippocampus plays an essential role in learning and memory and is one of the major sites implicated in neural diseases. The proper organization of the hippocampus during development is important for its function. We found that draxin, a repulsive axon guidance cue, was widely expressed in the developing hippocampus and draxin deficient mice possessed a smaller hippocampus, particularly in the anterior part of the structure. Quantification of this reduction revealed that the volume of the dentate gyrus of the mutant was significantly smaller compared to the normal counterpart. This size reduction seemed to be dependent on apoptosis rather than due to a decrease in the rate of cell division.
Zhang
Sanbing
S
Department of Developmental Neurobiology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto 860-8556, Japan.
Su
Yuhong
Y
Shinmyo
Yohei
Y
Islam
Shahidul M
SM
Naser
Iftekhar Bin
IB
Ahmed
Giasuddin
G
Tamamaki
Nobuaki
N
Tanaka
Hideaki
H
D000818:Animals; D017209:Apoptosis / Q000502:physiology; D001369:Axons / Q000502:physiology*; D049109:Cell Proliferation; D002478:Cells, Cultured; D004622:Embryo, Mammalian; D018507:Gene Expression Regulation, Developmental / Q000235:genetics; D006026:Glycoside Hydrolases / Q000235:genetics / Q000378:metabolism; D006624:Hippocampus / Q000166:cytology* / Q000196:embryology* / Q000378:metabolism; D036341:Intercellular Signaling Peptides and Proteins / Q000172:deficiency / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D009474:Neurons / Q000145:classification / Q000166:cytology* / Q000378:metabolism
D036341:Intercellular Signaling Peptides and Proteins; C534831:draxin protein, mouse; D006026:Glycoside Hydrolases; C089138:beta-galactanase