Comparative efficacies of two antimony regimens to treat Leishmania braziliensis-induced cutaneous Leishmaniasis in rhesus macaques (Macaca mulatta).
This study compared the efficacies of two N-methylglucomine antimoniate (MA) dose regimens for treating macaques with Leishmania braziliensis-induced chronic skin disease. Whereas all animals treated with the full dose (20 mg MA/kg/day) were cured, 50% of the monkeys receiving a low-dose regimen (5 mg MA/kg/day) relapsed. The antimony concentrations in macaque plasma and tissue samples were greater in the full-dose group than in that receiving a subtherapeutic MA regimen. Our data also suggest the presence of drug-induced hepatic pathology.
Grimaldi
G
G
Laboratório de Pesquisa em Leishmaniose, IOC/Fiocruz, Pavilhão Leônidas Deane, Sala 509, Av. Brasil 4365, 21045-360 Rio de Janeiro, RJ, Brazil. grimaldi@ioc.fiocruz.br
Porrozzi
R
R
Friedrich
K
K
Teva
A
A
Marchevsky
R S
RS
Vieira
F
F
Miekeley
N
N
Paumgartten
F J R
FJ
D000818:Animals; D000965:Antimony / Q000097:blood; D000981:Antiprotozoal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D007668:Kidney / Q000469:parasitology / Q000473:pathology; D007892:Leishmania braziliensis; D016773:Leishmaniasis, Cutaneous / Q000188:drug therapy* / Q000469:parasitology / Q000473:pathology; D008099:Liver / Q000469:parasitology / Q000473:pathology; D008253:Macaca mulatta; D008536:Meglumine / Q000008:administration & dosage / Q000627:therapeutic use*; D000077485:Meglumine Antimoniate; D009942:Organometallic Compounds / Q000008:administration & dosage / Q000627:therapeutic use*; D013154:Spleen / Q000469:parasitology / Q000473:pathology
D000981:Antiprotozoal Agents; D009942:Organometallic Compounds; D008536:Meglumine; D000077485:Meglumine Antimoniate; D000965:Antimony