title: CT characteristics of resolving ground-glass opacities in a lung cancer screening programme.
abstract: OBJECTIVE
  This study aimed at evaluating the computed tomography (CT) characteristics of resolving localized ground-glass opacities (GGOs) in a screening programme for lung cancer.
  
  
  METHODS
  280 patients at high-risk for lung cancer (221 men, 59 women; mean age, 58.6 years), divided into four groups (lung cancer history (n = 83), head and neck cancer history (n = 63), symptomatic (n = 88) and asymptomatic (n = 46) cigarette smokers), were included in a prospective trial with annual low-dose CT for lung cancer screening. We retrospectively reviewed all localized GGOs, analyzed the CT characteristics on initial CT scans and changes during follow-up (median 29.1 months). Variables associated with resolution of GGOs were tested using chi-square or Mann-Whitney tests.
  
  
  RESULTS
  A total of 75 GGOs were detected in 37 patients; 54.7% were present at baseline and 45.3% appeared on annual CT. During follow-up, 56.2% persisted and 43.8% disappeared. The resolving localized GGOs were significantly more often lobular GGOs (p = 0.006), polygonal in shape (p = 0.02), mixed (p = 0.003) and larger (p < 0.0001) than non-resolving localized GGOs.
  
  
  CONCLUSIONS
  Localized GGOs are frequent and many disappeared on follow-up. CT characteristics of resolving GGOs show significant differences compared to persistent ones. This study emphasizes the importance of short-term CT follow-up in subjects with localized GGOs.
authors.affiliation: Clinique Universitaire de Radiologie et Imagerie Médicale, Université Grenoble I, CHU Grenoble, France.
authors.forename: L
authors.initials: L
authors.lastname: Felix
authors.forename: G
authors.initials: G
authors.lastname: Serra-Tosio
authors.forename: S
authors.initials: S
authors.lastname: Lantuejoul
authors.forename: J F
authors.initials: JF
authors.lastname: Timsit
authors.forename: D
authors.initials: D
authors.lastname: Moro-Sibilot
authors.forename: C
authors.initials: C
authors.lastname: Brambilla
authors.forename: G R
authors.initials: GR
authors.lastname: Ferretti
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000453:epidemiology*; D008297:Male; D008403:Mass Screening / Q000706:statistics & numerical data*; D008875:Middle Aged; D015995:Prevalence; D015203:Reproducibility of Results; D018570:Risk Assessment; D012307:Risk Factors; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000706:statistics & numerical data*